Bacteremia: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.Gram-Negative Bacterial Infections: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.Staphylococcal Infections: Infections with bacteria of the genus STAPHYLOCOCCUS.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Gram-Positive Bacterial Infections: Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.Blood: The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.Cross Infection: Any infection which a patient contracts in a health-care institution.Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.Catheters, Indwelling: Catheters designed to be left within an organ or passage for an extended period of time.Catheterization, Central Venous: Placement of an intravenous CATHETER in the subclavian, jugular, or other central vein.Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.Methicillin-Resistant Staphylococcus aureus: A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.Streptococcal Infections: Infections with bacteria of the genus STREPTOCOCCUS.Endocarditis, Bacterial: Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Catheter-Related Infections: Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.Escherichia coli Infections: Infections with bacteria of the species ESCHERICHIA COLI.Gram-Negative Bacteria: Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.Pneumococcal Infections: Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.Community-Acquired Infections: Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.Klebsiella Infections: Infections with bacteria of the genus KLEBSIELLA.Methicillin Resistance: Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.Enterobacteriaceae Infections: Infections with bacteria of the family ENTEROBACTERIACEAE.Actinomycetales Infections: Infections with bacteria of the order ACTINOMYCETALES.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Vancomycin Resistance: Nonsusceptibility of bacteria to the action of VANCOMYCIN, an inhibitor of cell wall synthesis.Pseudomonas Infections: Infections with bacteria of the genus PSEUDOMONAS.Enterococcus: A genus of gram-positive, coccoid bacteria consisting of organisms causing variable hemolysis that are normal flora of the intestinal tract. Previously thought to be a member of the genus STREPTOCOCCUS, it is now recognized as a separate genus.Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Bacteriological Techniques: Techniques used in studying bacteria.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.Salmonella Infections: Infections with bacteria of the genus SALMONELLA.Gram-Positive Bacteria: Bacteria which retain the crystal violet stain when treated by Gram's method.Acinetobacter Infections: Infections with bacteria of the genus ACINETOBACTER.Bartonella Infections: Infections by the genus BARTONELLA. Bartonella bacilliformis can cause acute febrile anemia, designated Oroya fever, and a benign skin eruption, called verruga peruana. BARTONELLA QUINTANA causes TRENCH FEVER, while BARTONELLA HENSELAE is the etiologic agent of bacillary angiomatosis (ANGIOMATOSIS, BACILLARY) and is also one of the causes of CAT-SCRATCH DISEASE in immunocompetent patients.Bartonella quintana: A species of gram-negative bacteria in which man is the primary host and the human body louse, Pediculus humanus, the principal vector. It is the etiological agent of TRENCH FEVER.Viridans Streptococci: A large heterogeneous group of mostly alpha-hemolytic streptococci. They colonize the respiratory tract at birth and generally have a low degree of pathogenicity. This group of species includes STREPTOCOCCUS MITIS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS ORALIS; STREPTOCOCCUS SANGUIS; STREPTOCOCCUS SOBRINUS; and the STREPTOCOCCUS MILLERI GROUP. The latter are often beta-hemolytic and commonly produce invasive pyogenic infections including brain and abdominal abscesses.Klebsiella pneumoniae: Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.Daptomycin: A cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.Streptococcus pneumoniae: A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.Bacterial Typing Techniques: Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Trench Fever: An intermittent fever characterized by intervals of chills, fever, and splenomegaly each of which may last as long as 40 hours. It is caused by BARTONELLA QUINTANA and transmitted by the human louse.Equipment Contamination: The presence of an infectious agent on instruments, prostheses, or other inanimate articles.Staphylococcus: A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.Antibiotic Prophylaxis: Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Endocarditis: Inflammation of the inner lining of the heart (ENDOCARDIUM), the continuous membrane lining the four chambers and HEART VALVES. It is often caused by microorganisms including bacteria, viruses, fungi, and rickettsiae. Left untreated, endocarditis can damage heart valves and become life-threatening.Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.RNA, Ribosomal, 16S: Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.Streptococcus: A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.Immunocompromised Host: A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.Coagulase: Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.Hospitals, University: Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.Bacterial Infections: Infections by bacteria, general or unspecified.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Haemophilus Infections: Infections with bacteria of the genus HAEMOPHILUS.Pneumonia, Bacterial: Inflammation of the lung parenchyma that is caused by bacterial infections.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Leptotrichia: A genus of anaerobic, gram-negative bacteria in the family Fusobacteriaceae. Some species cause BACTEREMIA and some intra-amniotic infections.Infant, Newborn: An infant during the first month after birth.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Urinary Tract Infections: Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Aeromonas caviae: A species of gram-negative, facultatively anaerobic bacteria that is found in domestic and wild animals including birds, and fish. In humans it causes GASTROENTERITIS in young children and some adults.Fungemia: The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.Drug Resistance, Multiple, Bacterial: The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Electrophoresis, Gel, Pulsed-Field: Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.Bacteria, AnaerobicTooth Extraction: The surgical removal of a tooth. (Dorland, 28th ed)Gordonia Bacterium: A genus of gram-positive BACTERIA in the family Gordoniaceae, isolated from soil and from sputa of patients with chest disorders. It is also used for biotransformation of natural products.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Pneumonia, Pneumococcal: A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.Abscess: Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.Bartonella: A genus of gram-negative bacteria characteristically appearing in chains of several segmenting organisms. It occurs in man and arthropod vectors and is found only in the Andes region of South America. This genus is the etiologic agent of human bartonellosis. The genus Rochalimaea, once considered a separate genus, has recently been combined with the genus Bartonella as a result of high levels of relatedness in 16S rRNA sequence data and DNA hybridization data.Intensive Care Units: Hospital units providing continuous surveillance and care to acutely ill patients.Meningitis: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)Enterococcus faecium: A species of gram-positive, coccoid bacteria whose organisms are normal flora of the intestinal tract. Unlike ENTEROCOCCUS FAECALIS, this species may produce an alpha-hemolytic reaction on blood agar and is unable to utilize pyruvic acid as an energy source.Bacteroides Infections: Infections with bacteria of the genus BACTEROIDES.Enterobacteriaceae: A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Carbapenems: A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.Anti-Infective Agents: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.Staphylococcus epidermidis: A species of STAPHYLOCOCCUS that is a spherical, non-motile, gram-positive, chemoorganotrophic, facultative anaerobe. Mainly found on the skin and mucous membrane of warm-blooded animals, it can be primary pathogen or secondary invader.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Acinetobacter: A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.TaiwanGentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.Streptococcus bovis: A species of gram-positive, coccoid bacteria commonly found in the alimentary tract of cows, sheep, and other ruminants. It occasionally is encountered in cases of human endocarditis. This species is nonhemolytic.Acinetobacter baumannii: A species of gram-negative, aerobic bacteria, commonly found in the clinical laboratory, and frequently resistant to common antibiotics.

Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group. (1/3917)

BACKGROUND: Since the emergence of methicillin-resistant Staphylococcus aureus, the glycopeptide vancomycin has been the only uniformly effective treatment for staphylococcal infections. In 1997, two infections due to S. aureus with reduced susceptibility to vancomycin were identified in the United States. METHODS: We investigated the two patients with infections due to S. aureus with intermediate resistance to glycopeptides, as defined by a minimal inhibitory concentration of vancomycin of 8 to 16 microg per milliliter. To assess the carriage and transmission of these strains of S. aureus, we cultured samples from the patients and their contacts and evaluated the isolates. RESULTS: The first patient was a 59-year-old man in Michigan with diabetes mellitus and chronic renal failure. Peritonitis due to S. aureus with intermediate resistance to glycopeptides developed after 18 weeks of vancomycin treatment for recurrent methicillin-resistant S. aureus peritonitis associated with dialysis. The removal of the peritoneal catheter plus treatment with rifampin and trimethoprim-sulfamethoxazole eradicated the infection. The second patient was a 66-year-old man with diabetes in New Jersey. A bloodstream infection due to S. aureus with intermediate resistance to glycopeptides developed after 18 weeks of vancomycin treatment for recurrent methicillin-resistant S. aureus bacteremia. This infection was eradicated with vancomycin, gentamicin, and rifampin. Both patients died. The glycopeptide-intermediate S. aureus isolates differed by two bands on pulsed-field gel electrophoresis. On electron microscopy, the isolates from the infected patients had thicker extracellular matrixes than control methicillin-resistant S. aureus isolates. No carriage was documented among 177 contacts of the two patients. CONCLUSIONS: The emergence of S. aureus with intermediate resistance to glycopeptides emphasizes the importance of the prudent use of antibiotics, the laboratory capacity to identify resistant strains, and the use of infection-control precautions to prevent transmission.  (+info)

Acinetobacter bacteremia in Hong Kong: prospective study and review. (2/3917)

The epidemiological characteristics of 18 patients with acinetobacter bacteremia were analyzed. Patients (mean age, 55.5 years) developed bacteremia after an average of 14.1 days of hospitalization. Fifteen of 16 patients survived bacteremia caused by Acinetobacter baumannii. Cultures of blood from the remaining two patients yielded Acinetobacter lwoffii. Most patients (78%) resided in the general ward, while four patients (22%) were under intensive care. Genotyping by arbitrarily primed polymerase chain reaction analysis and the temporal sequence of isolation were more useful than phenotyping by antimicrobial susceptibility in the determination of the source of bacteremia, and the intravascular catheter was the leading infection source (39% of cases). The possibility of an association of glucose with the pathogenesis of acinetobacter infection was raised.  (+info)

Risk factors for nosocomial bloodstream infections due to Acinetobacter baumannii: a case-control study of adult burn patients. (3/3917)

Risk factors for Acinetobacter baumannii bloodstream infection (BSI) were studied in patients with severe thermal injury in a burn intensive care unit where A. baumannii was endemic. Of 367 patients hospitalized for severe thermal injury during the study period, 29 patients with nosocomial A. baumannii BSI were identified (attack rate, 7.9%). Cases were compared with 58 matched controls without A. baumannii BSI. The overall mortality rate was 31% among cases and 14% among controls; only two deaths (7%) were considered directly related to A. baumannii BSI. Molecular typing of A. baumannii blood isolates by means of randomly amplified polymorphic DNA analysis and pulsed-field gel electrophoresis revealed the presence of three different strain types. Multivariate analysis showed that female gender (P = .027), total body surface area burn of > 50% (P = .016), prior nosocomial colonization with A. baumannii at a distant site (P = .0002), and use of hydrotherapy (P = .037) were independently associated with the acquisition of A. baumannii BSI in burn patients. These data underscore the need for effective infection control measures for this emerging nosocomial problem.  (+info)

Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up. (4/3917)

Fifty-nine consecutive patients with definite Staphylococcus aureus infective endocarditis (IE) by the Duke criteria were prospectively identified at our hospital over a 3-year period. Twenty-seven (45.8%) of the 59 patients had hospital-acquired S. aureus bacteremia. The presumed source of infection was an intravascular device in 50.8% of patients. Transthoracic echocardiography (TTE) revealed evidence of IE in 20 patients (33.9%), whereas transesophageal echocardiography (TEE) revealed evidence of IE in 48 patients (81.4%). The outcome for patients was strongly associated with echocardiographic findings: 13 (68.4%) of 19 patients with vegetations visualized by TTE had an embolic event or died of their infection vs. five (16.7%) of 30 patients whose vegetations were visualized only by TEE (P < .01). Most patients with S. aureus IE developed their infection as a consequence of a nosocomial or intravascular device-related infection. TEE established the diagnosis of S. aureus IE in many instances when TTE was nondiagnostic. Visualization of vegetations by TTE may provide prognostic information for patients with S. aureus IE.  (+info)

Successful short-term suppression of clarithromycin-resistant Mycobacterium avium complex bacteremia in AIDS. California Collaborative Treatment Group. (5/3917)

During a randomized study of clarithromycin plus clofazimine with or without ethambutol in patients with AIDS and Mycobacterium avium complex (MAC) bacteremia, eight participants received additional antimycobacterial drugs following the detection of a clarithromycin-resistant isolate (MIC, > 8 micrograms/mL). A macrolide (seven received clarithromycin, one azithromycin) and clofazimine were continued; additional treatment included various combinations of ethambutol, ciprofloxacin, amikacin, and rifabutin. After the detection of a resistant isolate and before receipt of additional antimycobacterials, the median peak MAC colony count in blood was 105 cfu/mL (range, 8-81,500 cfu/mL). After additional antimycobacterials, the median nadir MAC colony count was 5 cfu/mL (range, 0-110 cfu/mL). Five (63%) of eight patients had a > or = 1 log10 decrease, including two who achieved negative blood cultures; all of these responses occurred in patients originally assigned to clarithromycin plus clofazimine. Treatment of clarithromycin-resistant MAC bacteremia that emerges during clarithromycin-based treatment can decrease levels of bacteremia and transiently sterilize blood cultures.  (+info)

Bartonella alsatica sp. nov., a new Bartonella species isolated from the blood of wild rabbits. (6/3917)

Bartonella species are considered as emerging human pathogens, with at least six different species pathogenic or possibly pathogenic for humans. However, little is known about Bartonella distribution, species polymorphism and pathogenicity in mammalian species. The objective of this work was to determine the presence, the frequency and the distribution of Bartonella species in wild rabbits (Oryctolagus cuniculus) caught in warrens in Alsace, France. Humans may come into contact with wild rabbits when hunting, especially when they are picked up with bare hands and at time of evisceration. Of 30 blood samples collected and cultured from wild rabbits, nine (30%) were positive for organisms morphologically similar to Bartonella spp. The bacteria appeared as small, fastidious, aerobic, oxidase-negative, Gram-negative rods which could be localized within erythrocytes. Their biochemical properties were similar to those of the genus Bartonella. The sequence of the 16S rRNA gene obtained from the rabbit isolates was highly related to the sequences of the different Bartonella species (97.8-99.3% similarity). The high DNA hybridization rate (81-90% similarity) between the three strains isolated from rabbit blood confirmed that they belong to the same bacterial species. Hybridization values, obtained with the nuclease-TCA method, when testing type strains of recognized Bartonella species (9-14% similarity), support the creation of a new species for the rabbit isolates. The name Bartonella alsatica is proposed for these strains isolated from the blood of wild rabbits. The type strain is IBS 382T (= CIP 105477T).  (+info)

Central venous catheter exchange by guidewire for treatment of catheter-related bacteraemia in patients undergoing BMT or intensive chemotherapy. (7/3917)

Current guidelines for the treatment of catheter-related bacteraemia (CRB) advise against central venous catheter (CVC) exchange because of the potential risk of prolonging infection. However, there are no consistent data proving this recommendation. We evaluated prospectively the usefulness of CVC exchange by guidewire for the treatment of CRB in patients undergoing BMT or intensive chemotherapy. CVC exchange was considered when fever and positive blood cultures persisted after 2 days of adequate antimicrobial therapy and no potential source of bacteraemia other than CVC could be identified. The guidewire exchange was preceded and followed by a slow infusion of adequate antimicrobial therapy. Bacteraemia was confirmed as catheter-related by demonstrating concordance between isolates from the tip and blood cultures by pulsed-field electrophoresis of genomic DNA. This procedure was performed in 19 episodes of bacteraemia during a 1-year period. Fourteen episodes (74%) were catheter-related and 71% of these were due to coagulase-negative staphylococci. Guidewire replacement was accomplished uneventfully 4 days after development of sepsis (range 3-6). In all cases, clinical signs of sepsis disappeared in less than 24 h after replacement. Definitive catheter withdrawal was carried out a median of 16 days (range 3-42) after guidewire exchange; in all cases, the tip culture was negative. We conclude that CVC replacement by guidewire under adequate antimicrobial therapy may be a reasonable option for the treatment of CRB when antimicrobial therapy alone has been unsuccessful.  (+info)

Listeria monocytogenes and Escherichia coli septicemia and meningoencephalitis in a 7-day-old llama. (8/3917)

Listeria monocytogenes and Escherichia coli were isolated from blood collected on presentation and tissues samples taken postmortem. Listeria monocytogenes was isolated from cerebrospinal fluid collected antemortem. The importance of passive transfer of immunity, the subtlety of neurologic signs in early meningitis, and considering blood-CSF penetration in antimicrobial selection are discussed.  (+info)

TY - JOUR. T1 - Risk factors for and clinical implications of mixed Candida/bacterial bloodstream infections. AU - Kim, S. H.. AU - Yoon, Young Kyung. AU - Min, Ja Kim. AU - Sohn, Jang Wook. PY - 2013/1/1. Y1 - 2013/1/1. N2 - Mixed Candida/bacterial bloodstream infections (BSIs) have been reported to occur in more than 23% of all episodes of candidaemia. However, the clinical implications of mixed Candida/bacterial BSIs are not well known. We performed a retrospective case-control study of all consecutive patients with candidaemia over a 5-year period to determine the risk factors for and clinical outcomes of mixed Candida/bacterial BSIs (cases) compared with monomicrobial candidaemia (controls). Thirty-seven (29%) out of 126 patients with candidaemia met the criteria for cases. Coagulase-negative staphylococci were the predominant bacteria (23%) in cases. In multivariate analysis, duration of previous hospital stay ≥7weeks (odds ratio (OR), 2.86; 95% confidence interval (CI), 1.09-7.53), ...
Report Publication; Hospital Performance: Healthcare-associated Staphylococcus aureus bloodstream infections in 2015-16, In Focus ; Released 2017; Golden Staph
... is the presence of bacteria in the bloodstream that are alive and capable of reproducing. It is a type of bloodstream infection.[9] Bacteremia is defined as either a primary or secondary process. In primary bacteremia, bacteria have been directly introduced into the bloodstream.[10] Injection drug use may lead to primary bacteremia. In the hospital setting, use of blood vessel catheters contaminated with bacteria may also lead to primary bacteremia.[11] Secondary bacteremia occurs when bacteria have entered the body at another site, such as the cuts in the skin, or the mucous membranes of the lungs (respiratory tract), mouth or intestines (gastrointestinal tract), bladder (urinary tract), or genitals.[12] Bacteria that have infected the body at these sites may then spread into the lymphatic system and gain access to the bloodstream, where further spread can occur.[13]. Bacteremia may also be defined by the timing of bacteria presence in the bloodstream: transient, intermittent, or ...
BACKGROUND Pseudomonas aeruginosa bacteremia (PAB) is associated with high mortality and morbidity rates, but the outcome for patients with PAB has not been recently well evaluated. METHODS Between 1997 and 1999, all episodes of PAB at the Hôtel-Dieu de France University Hospital, Lebanon, were analyzed to evaluate the outcome for patients with PAB. RESULTS Fifty-five episodes of PAB in 53 patients (26 episodes in men and 29 in women) were analyzed. The mean age of the patients in the cohort was 60.7 years (range: 18-89 years). The mean time between the onset of hospitalization and the first episode of PAB was 21 days (range: 0-77 days). Most of the tested isolates showed favorable in vitro susceptibility to ceftazidime (85%), amikacin (77%) and imipenem (67%). The overall in-hospital cumulative survival was 89% at one week and 49% at 2 months. Among the variables analyzed, four were statistically associated with a higher mortality rate: prior use of antimicrobials (85% vs 54%), use of systemic
Staphylococcus aureus is one of the leading causes of bloodstream infection, and these infections still have a high mortality. In certain clinical situations and for the planning of future prophylactic precautions, it is important to identify patients at risk of S. aureus bloodstream infection. Nearly all patients with S. aureus bloodstream...
The incidence of Pseudomonas aeruginosa bacteraemia (PAB) has remained stable over the last few decades.1-3 Although it is still primarily a nososcomial infection, the number of cases of community-acquired bacteraemia caused by this organism has increased, notably affecting patients with AIDS4,5 and neutropenic patients treated for neoplastic disease who received outpatient management.6 Predisposing conditions for PAB include compromised immunity, neutropenia, intensive care, surgical procedures, central venous and urinary catheters and previous cephalosporin therapy.1,3-5,6 Common factors predictive of a fatal outcome reported in the literature are septic shock, neutropenia, immunocompromised state, severe underlying disease, and in the elderly pneumonia, septic metastases, previous therapy and inappropriate choice of antimicrobial drugs for definitive treatment.1,6,7. P. aeruginosa has also emerged as an important bacteraemic pathogen in immunocompromised children,6,8,9 including ...
The incidence of Pseudomonas aeruginosa bacteraemia (PAB) has remained stable over the last few decades.1-3 Although it is still primarily a nososcomial infection, the number of cases of community-acquired bacteraemia caused by this organism has increased, notably affecting patients with AIDS4,5 and neutropenic patients treated for neoplastic disease who received outpatient management.6 Predisposing conditions for PAB include compromised immunity, neutropenia, intensive care, surgical procedures, central venous and urinary catheters and previous cephalosporin therapy.1,3-5,6 Common factors predictive of a fatal outcome reported in the literature are septic shock, neutropenia, immunocompromised state, severe underlying disease, and in the elderly pneumonia, septic metastases, previous therapy and inappropriate choice of antimicrobial drugs for definitive treatment.1,6,7. P. aeruginosa has also emerged as an important bacteraemic pathogen in immunocompromised children,6,8,9 including ...
To assess whether methicillin resistance is a microbial characteristic associated with deleterious clinical outcome, we performed a cohort study on 908 consecutive episodes of Staphylococcus aureus bacteremia and a case-control study involving 163 pairs of patients matched for preexisting comorbidities, prognosis of the underlying disease, length of hospitalization, and age. Of 908 bacteremic episodes, 225 (24.8%) were due to methicillin-resistant S. aureus (MRSA). Multivariate analysis did not reveal that methicillin resistance was an independent predictor for mortality when shock, source of bacteremia, presence of an ultimately or rapidly fatal underlying disease, acquisition of the infection in an intensive care unit (ICU), inappropriate empirical therapy, female sex, and age were taken into account. Nonetheless, methicillin resistance was an independent predictor for shock. The case-control study could not confirm that shock was linked to MRSA when prior antimicrobial therapy, inappropriate ...
All bacteraemic cases, from August 2006 to September 2007 were identified by reviewing all positive blood culture results from the microbiology department of our hospital. One thousand three hundred and sixty six cases were detected in 1336 patients. The rate of true bacteremia which was 13.1 and 10.7% of cultures were contaminated. Of the 1366 episodes of bloodstream infection, 55.3% were community-acquired and 44.7% were health-care associated. Gram-positive bacteria prevailed (58.5%), followed by gram negative bacilli (38.5%). Polymicrobial bacteremia was detected in 2.2% of cases. Coagulase-negative staphylococci (CoNS) were the leading cause (550/1366 = 40.3%), whilst enterococci,Staphylococcus aureus and Streptococci represented 8, 6.4 and 3.8% respectively. Pseudomonas aeruginosa was the commonest gram-negative isolate (155/1366 = 11.3%), followed by Escherichia coli (8.2%) and Acinetobactersp. (7.3%). Fungi were isolated in
The factors related to the occurrence of bacteraemia following urinary tract manipulation were studied in a large community hospital. During a 3-year period, forty-six of 326 episodes of hospital-acquired bacteraemia were associated with urinary tract manipulation. All thirty of forty-six cases felt to be definitely related to urinary tract manipulation (other obvious sources of bacteraemia being absent) had pre-existing urinary tract disease, especially of an obstructive type; only one in this group died from sepsis. The remaining sixteen patients had other possible sources of bacteraemia besides urinary tract manipulation and had disorders associated with defects in host defences; twelve (75%) in this group died from overwhelming sepsis. Thus, if bacteraemia occurs in a patient having had urinary tract manipulation but without any underlying urinary tract abnormality or impairment in host defences, its source should be searched for in other areas of the body.. ...
There were 1632 admissions with 45 nosocomial Gram-negative bacteremias in 44 patients. Infection rates of 28.2/1000 admissions and 12.1/10 000 patient-days remained stable over 5 years. The mean patient age was 55.3 years (range 17-86 years); 27.3% of patients were female, and 72.8% were male. The majority (95.6%) of bloodstream infections were monomicrobial, with only one episode of polymicrobial bacteremia. Common admitting diagnoses included respiratory failure, solid organ transplant, post-surgery, and multi-trauma. Seven bacterial species were identified; Pseudomonas aeruginosa and Enterobacter spp. were most common. Sources of bacteremia included pneumonia (48.9%), followed by central venous catheterization (22.2%). The mean time from admission to hospital to development of bacteremia was 32.9 days (95% confidence interval [CI] 0-100.9), and time from admission to the ICU was slightly less at 26.0 days (95% CI 0-90.1). Antimicrobial susceptibilities were highest for imipenem, gentamicin, ...
Evaluate the safety of ceftaroline fosamil in adult Subjects (≥ 18 years of age) with Staphylococcus aureus Bacteremia or with MRSA Bacteremia persisting after at least 72 hours of vancomycin and/or daptomycin treatment [ Time Frame: 60 days following completion of antibacterial therapy and discharge from the hospital, anticipated between 74 to 119 days ...
By Stan Deresinski, MD, FACP, FIDSA Clinical Professor of Medicine, Stanford University Dr. Deresinski reports no financial relationships relevant to this field of study. SYNOPSIS: The addition of rifampin to standard therapy failed to provide significant benefit to patients with bacteremia due to Staphylococcus aureus. SOURCE: Thwaites GE, Scarborough M, Szubert A, et al; United Kingdom Clinical Infection Research Group (UKCIRG). Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): A multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2017 Dec 14. pii: S0140-6736(17)32456-X. doi: 10.1016/S0140-6736(17)32456-X. [Epub ahead of . . .
S. aureus bacteremia (SAB) is a common condition with high rates of morbidity and mortality. Current methods used to diagnose SAB take at least a day, and often longer. Patients with suspected bacteremia must therefore be empirically treated, often unnecessarily, while assay results are pending. In this proof-of-concept study, we describe an inexpensive assay that detects SAB via the detection of micrococcal nuclease (an enzyme secreted by S. aureus) in patient plasma samples in less than three hours. In total, 17 patient plasma samples from culture-confirmed S. aureus bacteremic individuals were tested. 16 of these yielded greater nuclease assay signals than samples from uninfected controls or individuals with non-S. aureus bacteremia. These results suggest that a nuclease-detecting assay may enable the rapid and inexpensive diagnosis of SAB, which is expected to substantially reduce the mortality and morbidity that result from this condition.
Staphylococcus aureus bacteraemia (SAB) is commonly complicated by metastatic infection or relapse after treatment. Objectives. The study aim was to determine the role of bacterial, host, and management factors in development of complicated SAB. Methods. A prospectively-conducted observational study gathered data on predisposition, management and outcome of 100 consecutive SAB cases. Antibiotic susceptibilities and genetic lineage of bacterial isolates were determined. Further clinical and microbiological data were gathered on two retrospective series from 1999-2000 (n = 57) and 2004 (n = 116). Results. In the prospective cases, 27% met our definition of complicated disease. Expressed as RR and 95% CI, complicated disease was associated with diabetes (1.58, 1.00-2.48), injecting-drug use (5.48, 0.88-33.49), community-onset of symptoms (1.4, 1.02-1.92), and symptom duration ,/=48 hours prior to starting effective antibiotic therapy (2.10, 1.22-3.61). Uncomplicated disease was associated with the ...
In 2014-15, 1,490 cases of hospital-associated Staphylococcus aureus bacteraemia (SAB) were reported in Australian public hospitals. The national rate of SAB in public hospitals was 0.77 cases per 10,000 days of patient care, and all states and territories had rates below the national benchmark of 2.0 cases per 10,000 days of patient care. Between 2010-11 and 2014-15, rates of SAB decreased from 1.10 cases to 0.77 cases per 10,000 days of patient care.. ...
Clinical questions: What are the trends in patient outcome for Staphylococcus aureus bacteremia (SAB)? Does the use of evidence-based care processes decrease mo
What drug can cause Streptococcal Bacteraemia as their side effect? Check drug and medication side effect reports associated with Streptococcal Bacteraemia
It is generally well established that dental cares cause bacteremia, and that most are due to streptococcal strains [1,2]. It is, consequently, reasonable to think that prescribing antibiotics before dental cares decreases the incidence of such bacteremia. Globally, the discordant results between the different kinds of studies analyzed in the paper by Cahill et al. [1] are clearly insufficient to conclude that antibiotic prophylaxis prevents bacteremia due to streptococci. In our view, this observation can be explained by the fact that dental care is not the only cause of streptococcal bacteremia. Indeed, such bacteremia are extremely common, and it has been demonstrated that they can occur after chewing and after brushing in patients with periodontitis (cumulatively in 25% and 20% of cases, respectively) [2]. It is, therefore, fairly unlikely that bacteremias due to dental cares are more responsible for endocarditis than other kinds of bacteremias. In practice, this implies that the only ...
An improvement resource to help health and social care economies reduce the number of Gram-negative bloodstream infections (BSIs) with an initial focus on Escherichia coli (E.coli).
article{1887963, author = {Reunes, Sofie and Rombaut, Vicky and Vogelaers, Dirk and Brusselaers, Nele and Lizy, Christelle and Cankurtaran, Mustafa and Labeau, Sonia and Petrovic, Mirko and Blot, Stijn}, issn = {0953-6205}, journal = {EUROPEAN JOURNAL OF INTERNAL MEDICINE}, keyword = {ANTIMICROBIAL THERAPY,HOSPITAL MORTALITY,MULTIDRUG-RESISTANCE,OLD PATIENTS,ATTRIBUTABLE MORTALITY,Bloodstream infection,Elderly,Risk factors,Geriatric patient,Mortality,CRITICALLY-ILL PATIENTS,CARE-UNIT PATIENTS,INTENSIVE-CARE,PSEUDOMONAS-AERUGINOSA,BACTEREMIA}, language = {eng}, number = {5}, pages = {e39--e44}, title = {Risk factors and mortality for nosocomial bloodstream infections in elderly patients}, url = {http://dx.doi.org/10.1016/j.ejim.2011.02.004}, volume = {22}, year = {2011 ...
The outcome of patients with bacteraemia is influenced by the initial selection of adequate antimicrobial therapy. The objective of our study was to clarify the influence of different crude data correction methods on a) microbial spectrum and ranking of pathogens, and b) cumulative antimicrobial susceptibility pattern of blood culture isolates obtained from patients from intensive care units (ICUs) using a computer based tool, MONI. Analysis of 13 ICUs over a period of 7 years yielded 1427 microorganisms from positive results. Three different data correction methods were applied. Raw data method (RDM): Data without further correction, including all positive blood culture results. Duplicate-free method (DFM): Correction of raw data for consecutive patients results yielding same microorganism with similar antibiogram within a two-week period. Contaminant-free method (CFM): Bacteraemia caused by possible contaminants was only assumed as true bloodstream infection, if an organism of the same species was
In Australia, MRSA bacteraemias cause up to 40 per cent of all healthcare-acquired Staphylococcus aureus (S. aureus) bacteraemia [9]. MRSA bacteraemias are associated with increased risk of mortality [10] and contribute a considerable cost to the healthcare system due to the need for prolonged hospital stays, re-admissions and additional diagnostic tests and treatment [11]. National reporting of healthcare acquired S. aureus bacteraemias, including those caused by MRSA, was introduced in Australia in 2008. MRSA bacteraemia incidences and rates also are a key performance indicator for jurisdictions under the National Healthcare Agreement [12]. This section reports inpatient and non-inpatient healthcare-acquired MRSA bacteraemias data. ...
Early administration of appropriate antimicrobials has been correlated with a better prognosis in patients with bacteremia, but the optimum timing of early antibiotic administration as one of the resuscitation strategies for severe bacterial infections remains unclear. In a retrospective cohort study, adults with community-onset bacteremia at the emergency department (ED) were analyzed. Effects of different cutoffs of time to appropriate antibiotic (TtAa) administration after arrival at the ED on 28-day mortality were examined, after adjustment for independent predictors of mortality identified by multivariate regression analysis. Among 2349 patients, the mean (interquartile range) TtAa was 2.0 (|1 to 12) hours. All selected cutoffs of TtAa, ranging from 1 to 96 hours, were significantly associated with 28-day mortality (adjusted odds ratio (AOR), 0.54-0.65, all P | 0.001), after adjustment of the following prognostic factors: fatal comorbidities (McCabe classification), critical illness (Pitt
The aim of this study was to assess the sensitivity and specificity of catheter-drawn and peripheral blood cultures. Paired blood culture samples collected over a 44-month period from a 280 bed Brisbane metropolitan hospital were analysed, using standard clinical and microbiological criteria, to determine whether blood culture isolates represented true bacteraemias or contamination. Catheter-collected cultures had a specificity of 85% compared with 97% for peripheral cultures. In only two instances (0.2%) was the diagnosis of clinically significant bacteraemia made on the basis of catheter culture alone. This study concluded that cathetercollected samples are not a good test for true bacteraemia, and that peripheral cultures are more reliable when the results of the paired cultures are discordant.. ...
Background: Improvements in central line placement practices have decreased the rates of central line associated bloodstream infections (CLABSI). Further progress in reducing infection may rest on processes related to line maintenance and care. Methods: We evaluated the effect of an alcohol disinfection cap on rates of nosocomial bacteremia. The plastic caps fit on the exposed ends of IV needless access devices and contain a pad saturated with 70% isopropyl alcohol for disinfection: we alternated between similar products by two different manufacturers. The caps were placed on all ports of peripheral and central lines when not in use. Four hospital units with higher central line use were chosen for this yearlong intervention (an intensive care unit, a step down unit, and two medical surgical units). Nosocomial bloodstream infections and CLABSI were monitored for these units, along with four units not part of this intervention (to control for changes over time). The year prior to implementation ...
Staphylococcus aureusis a leading cause of both community- and healthcare-associated bacteremia.S. aureusbacteremia (SAB) is associated with increased morbidity and mortality, even with appropriate therapy.The epidemiology and clinical features of SA
The non-hematologic malignancies included esophageal cancer (2) and bladder cancer (1). Seven patients (54%) were neutropenic (defined as Absolute Neutrophil Count , 1500 cells/uL) with an average duration of 14 days. The median age was 60 years. There was no gender predilection. Seven patients had mucositis at the time of diagnosis either due to chemotherapy or graft versus host disease. One patient had gingivitis with a dental abscess. None of the patients developed infective endocarditis. Most patients were on empiric antimicrobial therapy with ciprofloxacin, levofloxacin or piperacillin/tazobactam at the time of breakthrough bacteremia. Almost all patients received vancomycin as definitive treatment. All the patients had transient bacteremia with an average duration of positive blood cultures of 1 day. The 30-day mortality rate was 16.67%. Mortality was not attributable to NVS bacteremia ...
To describe the rate of response to an antibiotic-lock technique (ALT) in the treatment of venous access port (VAP)-related bacteremia and to analyze the role of the reservoir in the persistence of infection, we reported the data from 12 human immunodeficiency virus-infected and 8 oncologic patients with VAP-related bacteremia. The ALT consisted of intracatheter delivery of antibiotics and was associated with a systemic antibiotic infusion. We monitored clinical manifestations and performed qualitative and quantitative blood cultures during and at the end of the treatment. Four patients had catheters removed before antibiotic treatment. Of the 16 patients who were treated with the ALT, 5 (31%) were cured, as determined by negative cultures of blood and of samples from the catheter; 2 (12.5%) were cured but had recurrent infection with another microorganism; and 9 (56%) had persistent positive cultures of blood and of samples from the tip, reservoir, or both of the VAP. Limited efficacy of the ...
|p style=text-align: left;||em|New study published in |/em|Mayo Clinic Proceedings|em| shows that statin use was associated with decreased risk of blood infection with |/em|Staphylococcus aureus|em| acquired outside of a hospital.|/em||/p|
Staphylococcus aureusis a leading cause of community-acquired and healthcare-associated bacteremia. The annual incidence ofS. aureusbacteremia (SAB) in the United States is 38.2 to 45.7 per 100,000 person-years; elsewhere in the industrialized world,
This study shows a sharp upswing in some potentially lethal hospital infections in the summer months. Hospitals must be on the alert for spread of infections in warm weather.
Background: The Verigene® Gram-Negative Blood Culture Test (BC-GN) detects 4 Gram-negative genera, 4 species, and 6 resistance genes within 2 hours of blood culture positivity, shortening the time from Gram stain to pathogen and resistance gene identification. The purpose of this study was to determine the impact of BC-GN testing paired with an antimicrobial stewardship intervention on antimicrobial and clinical outcomes.. Methods: This retrospective pre-post study compared patients admitted with a blood culture positive for a Gram-negative organism detectable by the BC-GN before (January 1, 2015 - July 1, 2015) and after (July 15, 2015 - January 15, 2016) this microarray test was implemented. The primary objective was to compare time from Gram stain to antimicrobial switch pre and post implementation. Secondary objectives included time from Gram stain to active treatment, in-hospital mortality, and hospital length of stay.. Results: 877 patients with Gram-negative bacteremia were included, 456 ...
Extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) isolates are susceptible to only one or two classes of antibiotics. In 2011-2012, we investigated an outbreak of XDR-PA affecting children with onco-hematological diseases. Outbreak investigation included ascertainment of cases, tracing of intestinal carriers and environmental surveillance. Contact precautions were adopted for patients with infection or colonization. Isolates were tested for antimicrobial susceptibility; phenotypic confirmation of carbapenemase production was performed, and carbapenemase genes were tested by multiplex polymerase-chain-reaction (PCR). Genotypes were determined by pulsed-field gel electrophoresis (PFGE). XDR-PA was isolated from 27 patients; 12 had bacteremia, 6 other infections and 9 were colonized. Severe neutropenia was significantly associated with bacteremia. Bloodstream-infection mortality rate was 67%. All isolates were resistant to carbapenems, cephalosporins and penicillins + β-lactamase inhibitors.
BACKGROUND AND OBJECTIVES: Bacteraemia caused by Enterobacteriaceae (EB) producing extended-spectrum ?-lactamase (ESBL+) has been associated with higher mortality compared with non-ESBL-producing (ESBL-) EB bacteraemia in observational studies. We conducted a systematic review and meta-analysis of these studies to assess how adjusting for confounding in multivariate analyses affects the pooled estimate, and whether multivariate analyses that include intermediates in the causal pathway of outcome (sepsis severity and inadequate empirical therapy) have lower estimates of attributable mortality. DATA SOURCES: PubMed search on 23 November 2010 followed by manually searching reference lists of included studies. STUDY ELIGIBILITY CRITERIA: Cohort studies published in English with separate mortality rates for ESBL+ and ESBL- EB bacteraemia. SYNTHESIS METHODS: Random-effects pooling of unadjusted and adjusted ORs followed by subgroup analyses to explore effects of adjustment procedures on adjusted ORs. ...
Reportstack has announced a new market research publication on Bacteremia Global Clinical Trials Review, H2, 2013 which provides elemental information and data relating to the clinical trials on Bacteremia. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Bacteremia. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by team of industry experts ...
The clinical and economic impact of bloodstream infections (BSI) due to multidrug resistant (MDR) Gram negative bacteria is incompletely understood. From 2009-2015, all adult inpatients with Gram negative BSI at our institution were prospectively enrolled. MDR status was defined as resistance to ≥3 antibiotic classes. Clinical outcomes and inpatient costs associated with the MDR phenotype were identified. Among 891 unique patients with Gram negative BSI, 292 (33%) were infected with MDR bacteria. In an adjusted analysis, only history of Gram negative infection was associated with MDR BSI versus non-MDR BSI (odds ratio 1.60; 95% confidence interval [CI] 1.19-2.16; P=0.002). Patients with MDR BSI had increased BSI recurrence (1.7% [5/292] vs 0.2% [1/599]; P=0.02) and longer hospital length of stay (median 10.0 vs.8.0 days; P=0.0005). Unadjusted in-hospital mortality did not significantly differ between MDR (26.4% [77/292]) and non-MDR (21.7% [130/599]) groups (P=0.12). Unadjusted mean costs were ...
Our study population comprised 3,394,936 individuals (median age = 43.2 years). Over a median follow-up of 15.9 years, 13,181 individuals acquired SAB. SES was inversely associated with SAB acquisition, which declined with increasing age, e.g. in individuals with lowest SES, IRRs were 3.78 (95% confidence interval [CI] = 2.89-4.95) in age 30-50 years, 1.87 (CI = 1.60-2.18) in age > 50-70 years and 1.31 (CI = 1.11-1.54) in age > 70 years (interaction-p < 0.0001). Adjustment for comorbidities attenuated the IRRs, but the pattern persisted. No association between SES and endocarditis risk among patients with SAB was observed ...
Αmong 145 patients with gram-negative COB, 83 (57.2%) had HCAB and 62 (42.8%) had CAB. The frequency of malignant tumors, renal insufficiency and dementia was higher in patients with HCAB than with CAB. In both groups Escherichia coli was the mostcommon causative agent but the prevalence of Klebsiella pneumoniae in HCAB was significantly higher than CAB (19.3% vs. 4.8%). Patients with HCAB had higher Charlson score and higher Pitt bacteremia score, less frequent administration of appropriate empirical antibiotic treatment and higher probability of death than patients with CAB.. The antimicrobial resistance in HCAB και CAB patients respectively, was found 27/83 (32.5%) vs. 4/62 (6.5%) (P,.001) to third-generation cephalosporins (3GC), 22/83 (26.5%) vs. 7/62 (11.3%) (P=.021) to aminoglycosides, 29/83 (34.9%) vs. 9/62 (14.5%) (P=.005) to quinolones. Bacteria that produced ESBL were 16/76 (21.1%) vs. 2/59 (3.4%) (P=.003), and carbapenem-resistant were 10/83 (12.0%) vs. 2/62 (3.2%) (P=.056) in ...
Researchers observed a 95.3% reduction of S pneumoniae bacteremia after implementation of routine immunization with the pneumococcal conjugate vaccine.
L PARVARESH¹, S C-A CHEN, V W LEE³´⁴, V SINTCHENKO¹´²´⁴. ¹Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, Westmead, NSW; ²Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, NSW Health Pathology, Westmead Hospital, NSW; ³Department of Renal Medicine, Westmead Hospital, Westmead, NSW; ⁴Sydney Medical School, The University of Sydney, NSW. Aim: This review of episodes of bacteraemia in haemodialysis patients, admitted to a tertiary hospital in Sydney and dialysed through any type of vascular access, was conducted in order to determine the frequency and patterns of antimicrobial resistance or causative organisms.. Background: Bacteraemia is the most common infection-related cause of mortality in patients with kidney disease on haemodialysis. Staphylococcus aureus, coagulase negative staphylococci (CONS), Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., and Enterobacter spp. are the most frequent isolates. Antibiotic ...
Monotherapy was the empirical therapy most frequently used (267, 67.8 %), mainly consisting of piperacillin/tazobactam (49.4 %) and carbapenems (37.1 %). On the other hand, combined treatment was used in 127 (32.2 %) cases, with carbapenems plus colistin being the most common combination. The EAT was adequate in 75.4 % of the cases. Seven- and 30-day mortality was 17 % and 23.9 %, respectively, related to infection in more than 80 % of the cases. Marked differences were observed in treatment and outcomes between the two groups. Carbapenems (35.4 versus 61.9 %, p=0.0001) and colistin (11.9 versus 31.5 %, p=0.0001) were more frequently used in the MDR GNR group, with worse outcomes in this group regarding breakthrough bacteremia (4 versus 14.3 %, p=0.0001), clinical response (75.2 versus 54.2 %, p=0.0001), and 30-day mortality (15.9 versus 34.5 %, p=0.0001).. Discussion. This prospective multicenter study of bacteremia in both cancer and HSCT patients was carried out in Argentina to help ...
... Enferm Infecc Microbiol Clin. 2011 Mar;29 Suppl 4:48-53. Authors: Fortún J, Sanz MÁ, Madero L, López J, de la Torre J, Jarque I, Vallejo C. The present article is an update of the literature on bacteraemia in onco-hematologic patients. A multidisciplinary group of Spanish physicians with an interest in this field selected the most important papers published recently. Papers from the fields of basic science, epidemiology, causative microorganisms and clinical syndromes are discussed. Important aspects of these studies include the assessment of different strategies in the management of fever in neutropenic patients and the validation of specific scores. Moreover, early identification of patients at risk of bacterial and of multi-drug resistant infections is a topic of increasing interest.. PMID: 21458720 [PubMed - indexed for MEDLINE]. ...
Problem Bacteraemia in dialysis units accounts for major morbidity, mortality, and antibiotic usage. Risk is much greater when lines rather than fistulas are used for haemodialysis. Surveillance is critical for infection control, but no standardised surveillance scheme exists in the United Kingdom.. Design Prospective study in a London dialysis unit of the implementation and applicability of a dialysis associated bacteraemia surveillance scheme developed in the United States and its effect on bacteraemia, antibiotic usage, and admission.. Setting Hammersmith Hospital dialysis unit, London, where 112 outpatients receive dialysis three times weekly. Between June 2002 and December 2004, 3418 patient months of data were collected.. Key measures for improvement Successful adoption of the scheme and reductions in bacteraemia rates, antibiotic usage, and admission to hospital.. Strategy for improvement Embedding the surveillance scheme in the units clinical activity.. Effects of change Raised ...
To describe the difference of the clinical features, bacteremia severity, and outcome of patient with community-onset bacteremic pneumonia between Pseudomonas, Klebsiella, and other causative microorganisms, the total 278 adults with community-onset monomicrobial bacteremic pneumonia were studied in a retrospective cohort. Klebsiella (61 patients, 21.9%) and Pseudomonas (22, 7.9%) species was the leading and the fifth common pathogen, respectively. More patients having initial presentation with critical illness (a Pitt bacteremia score ≥ 4) and a fatal comorbidity (McCabe classification) as well as a higher short- (30-day) or long-term (90-day) mortality rate was evidenced in patients infected with Klebsiella or Pseudomonas species, compared to other causative microorganisms ...
Mandatory reporting of Staphylococcus aureus bacteraemia (bloodstream infections) should be introduced to help improved health care practices and save lives...
Eight of 30 persons with normal-appearing gingiva developed bacteremia after using an oral irrigation device. In comparison, none of 30 persons using toothbrushes developed bacteremia. This difference is statistically significant and suggests that the use of an oral irrigation device is contraindicated in persons at risk of bacterial endocarditis. ...
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Ritvo, Rachel, "Transient bacteremia due to suction abortion: implications for SBE antibiotic prophylaxis" (1977). Yale Medicine Thesis Digital Library. 3071 ...
Results:. Eight patients aged 19 to 82 years (six women) underwent FMT. They experienced a median of four previous episodes of CDI (range 3-8). The mean duration of CDI was 18 days (range 3-36) before FMT. All procedures were performed by colonoscopy. Effectiveness with one session of FMT was 100%. During the follow-up period (median 24 months, range 7-55), two patients developed CDI, one of them after using antibiotics. Adverse events were reported in three patients. Two had bloating and one patient with Crohns disease and a history of bacteremia had an episode of Escherichia coli bacteremia. All patients would use FMT again if necessary. ...
128 episodes of bacteremia associated with NP were identified. In 110 episodes a tracheal surveillance culture 48-96 h prior to bacteremia was available: this culture predicted the pathogen in 67 episodes (61%). Overall rates of appropriate empiric antibiotic therapy within 24 and 48 h were 62 and 87%, respectively. Pathogen prediction was associated with a significantly higher rate of appropriate antibiotic therapy within 24 h (71 vs 45%; p = 0.01), but not within 48 h (91 vs 82%; p = 0.15). Crude in-hospital mortality was 50%. Pathogen prediction was associated with increased survival in univariate (OR 0.43; CI 0.19-0.93; p = 0.04) and multivariate analysis (OR 0.32; CI 0.12-0.82; p = 0.02). Multivariate analysis further identified age (OR 1.04; CI 1.01-1.07; p = 0.02), increasing APACHE II score (OR 1.08; CI 1.02-1.15; p = 0.01), and methicillin-resistant Staphylococcus aureus (OR 5.90; CI 1.36-25.36; p = 0.01) and Pseudomonas aeruginosa (OR 3.30; CI 1.04-10.4; p = 0.04) as independent risk ...
her current employer. Two years ago, Greene led a team of professionals to reduce bacteria associated with central venous catheters (CVC) in the facilitys intensive care unit and expanded the program to the entire organization. CVC bacteremia can prolong hospitalization, increase healthcare costs and lead to death. Within three months, death attributed to CVC bacteremia decreased from 4 percent to zero. Two years later, the overall bacteremia rate decreased 72 percent.. Greenes work garnered Rochester General Hospital, the Hospital Association of New York States 2005 Pinnacle award for quality.. Dolan is currently employed as the hospital epidemiologist at The Childrens Hospital in ...
For Staph aureus bacteraemia in a patient with a CVC or permcath, the line should be removed unless there are major contraindications preventing this. A line should only be kept in situ if removal means that there is no alternative means of dialysis or if risk associated with removal outweighs risk of recurrent bacteraemia and risk of developing deep seated Staph aureus infection (e.g. discitis, osteomyelitis, endocarditis ...
Intra-dialytic instillation of tissue plasminogen activator (tPA) may be associated with increased catheter-related bacteremia (CRB).
Blood cultures are used to detect bacteria or fungi in the blood and guide treatment and to identify a blood infection (septicemia) that can lead to sepsis. Blood cultures are ordered when a person has signs and symptoms of sepsis, which indicates that bacteria, fungi, or their toxic by-products are causing harm in the body.
AGUSTÍN JULIÁN-JIMÉNEZ, FRANCISCO JAVIER CANDEL, JUAN GONZÁLEZ-DEL CASTILLO, EN REPRESENTACIÓN DEL GRUPO INFURG-SEMES (GRUPO DE ESTUDIO DE INFECCIONES DE LA SOCIEDAD ESPAÑOLA DE MEDICINA DE URGENCIAS Y EMERGENCIAS). Between all patients attended in the Emergency Department (ED), 14.3% have an infectious disease diagnosis. Blood cultures (BC) are obtained in 14.6% of patients and have a profitability of 20%, whereas 1% are considered as contaminated and 1-3% of positive cultures correspond to discharge patients ("hidden bacteraemia"). The highest number of confirmed bacteraemias comes from the samples of patients with urinary tract infections, followed by community-acquired pneumonia. The suspicion and detection of bacteraemia have an important diagnostic and prognostic significance and could modify some important making-decisions (admission, BC request, administration of appropriate and early antimicrobial, etc). Therefore, finding a predictive model of bacteraemia useful and applicable in ...
Bacteremia and septicemia occur when the persistent presence of bacterial organisms in a cats bloodstream becomes systemic, meaning that it has spread throughout the body. This is also referred to as blood poisoning, or septic fever. Learn more about the causes and treatment of this condition on PetMD.com.
Pfizer is currently recruiting for the NCT00428051 Pneumonia, Meningitis, Bacteremia, Sepsis Cancer trial. Review trial description, criteria and location information here.
Rattanaumpawan, P., Ussavasodhi, P., Kiratisin, P. and Aswapokee, N. (2013) Epidemiology of Bacteremia Caused by Uncommon Non-Fermentative Gram-Negative Bacteria. BMC Infectious Diseases, 13, 167-175.
CXCL10 improves outcome by decreasing bacteremia in IFNAR−/− mice. (A) SEV129 wild-type mice (n = 10), IFNAR−/− mice (n = 11), or IFNAR−/− mice with
Compare risks and benefits of common medications used for Bacteremia. Find the most popular drugs, view ratings, user reviews, and more...
Background: Staphylococcus aureus bacteremia (SAB) is a severe disease carrying a high risk of complications such as metastatic disease with deep-seated foci of infection, endocarditis, severe sepsis or recurrences - in particular in community-onset cases. In a recent European survey (n=1,838)[for full text, please go to the a.m. URL ...
Results. A total of 1,425 blood cultures were finally enrolled in the study. Of those were considered true bacteremia 179 (12.6 %) and as negative blood cultures 1,246 (87.4 %). Amongst negatives, 1,130 (79.3%) without growth and 116 (8.1%) as contaminants blood cultures. Five variables were significantly associated with true bacteraemia: serum procalcitonin (PCT) ≥ 0.51 ng/ml [odds ratio (OR): 4.52; 95% confidence interval (CI): 4.20-4.84, P ,.001], temperature , 38.3°C [OR:1.60; 95% CI:1.29-1.90, P ,.001], systolic blood pressure (SBP) , 100 mmHg [OR:3.68; 95% CI:2.78-4.58, P ,.001], septic shock [OR:2.96; 95% CI:1.78-4.13, P ,.001] and malignancy [OR:1.73; 95% CI:1.27-2.20, P ,.001 ...
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Antibiotic resistance in E. coli is of particular concern because it is the most common Gram-negative pathogen in humans, the most common cause of urinary tract infections, a common cause of both community and hospital-acquired bacteraemia as well as a cause of diarrhea. In addition, resistant E. coli strains have the ability to transfer antibiotic resistance not only to other strains of E.coli, but also to other bacteria within the gastrointestinal tract and to acquire resistance from other organisms. [2] ...
Antibiotic resistance in E. coli is of particular concern because it is the most common Gram-negative pathogen in humans, the most common cause of urinary tract infections, a common cause of both community and hospital-acquired bacteraemia as well as a cause of diarrhea. In addition, resistant E. coli strains have the ability to transfer antibiotic resistance not only to other strains of E.coli, but also to other bacteria within the gastrointestinal tract and to acquire resistance from other organisms. [2] ...
Staphylococcus aureus is a predominant cause of community-acquired and nosocomial infections. In addition, it is the most common cause of skin and skin structur...
Bacterial diseases affect all animals and cattle are no less immune or unique to their onslaught. bacteria can cause varying ranges of illness in cattle from mild dermatitis to sepsis and death. Appropriate antimicrobial therapy should be based on isolation and culture and sensitivity of causative bacteria. Bacterial diseases in cattle include: ...
This page includes the following topics and synonyms: Bloodstream Infections in Hemodialysis, Fever in End Stage Renal Disease, Febrile Dialysis Patient, Bacteremia in ESRD, Sepsis in Hemodialysis Patient.
A new study may change our understanding of bacteremia, a bloodstream infection commonly seen in preterm infants in neonatal intensive care units.
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This report discusses a study of antimicrobial susceptibility patterns of blood culture isolates between 2001 and 2009 in non-specialty adult patients at an Australian tertiary referral centre, which found that gram negative bloodsteam infections appeared to be re-emerging, particularly in community onset infections and also amongst the younger patients at the study institution.
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While the clinicians could not rule out the possibility of transmission from a colonized household member, their final diagnosis was late-onset GBS disease attributable to high maternal colonization secondary to consumption of GBS-infected placental tissue.
Learn about the causes, symptoms, diagnosis & treatment of Biology of Infectious Disease from the Professional Version of the Merck Manuals.
Harvard scientists are developing a device known as the spleen-on-a-chip, for treating sepsis by filtering pathogens from the blood.
Background: There is little information on nasopharyngeal (NP) flora or bacteremia in HIV-infected children. Our aim was to describe the organisms and antimicrobial resistance patterns in children enrolled in a prospective ...
理化学研究所 脳科学総合研究センター(理研BSI)、馬塚 れい子, Ph.D.の概要ページ。研究内容や主要論文などを掲載しています。
理化学研究所 脳科学総合研究センター(理研BSI)、岡本 仁, M.D., Ph.D.の概要ページ。研究内容や主要論文などを掲載しています。
Pseudomonas aeruginosa bloodstream infection (BSI) is predominantly acquired in the hospital setting. Community-onset infection is less common. Differences in epidemiology, clinical features, microbiological factors and BSI outcomes led to the separation of bacterial community-onset BSI into the categories of healthcare-associated infection (HCAI) and community-acquired infection (CAI). Community-acquired P. aeruginosa BSI epidemiology is not well defined in the literature. In addition, it is also not clear if the same factors separate CAI and HCAI BSI caused by P. aeruginosa alone. A retrospective multicentre cohort study was performed looking at P. aeruginosa BSI from January 2008 to January 2011. Strict definitions for HCAI and CAI were applied. Extensive epidemiological, clinical and outcome data were obtained. Thirty-four CAI episodes and 156 HCAI episodes were analysed. The CAI group could be characterised into seven distinct categories based on comorbidities and clinically suspected ...
TY - JOUR. T1 - Septic pulmonary embolism of unknown origin in patients with staphylococcus aureus bacteremia; A case report and review of 18 cases. AU - Camargo Galvis, Jose. AU - Sakoulas, George. AU - Dodd, Jonathan D.. AU - Muñoz-Gomez, Sigridh. AU - Kadeishvili, Khatuna. AU - Lenox, Theodore. PY - 2013/7. Y1 - 2013/7. N2 - Septic pulmonary embolism (SPE) results when fragments of thrombus containing bacteria or fungi travel to the pulmonary circulation and lodge in segmental and subsegmental pulmonary arteries. Almost invariably such embolization implies the presence of an endovascular infection (typically endocarditis, septic thrombophlebitis, or catheter-related infection) as the source of embolism. Here we report a case of Staphylococcus aureus bacteremia complicated with SPE in a patient who had no septic foci other than a soft tissue infection. We found 17 similar cases in the literature and reviewed their clinical presentation and outcomes. The most common presenting symptoms were ...
TY - JOUR. T1 - Endemic Burkholderia cepacia bacteraemia. T2 - Clinical features and antimicrobial susceptibilities of isolates. AU - Yu, Wen Liang. AU - Wang, Der Yuan. AU - Lin, Cheng Wen. AU - Tsou, Mei Fen. PY - 1999. Y1 - 1999. N2 - Burkholderia cepacia has emerged as a nosocomial pathogen, causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. Reports of clinical features of endemic B. cepacia bacteraemia in non-CF patients are rare. Twenty-five patients with B. cepacia bacteraemia were matched with 25 controls with nosocomial Escherichia coli bacteraemia at China Medical College Hospital, Taichung, Taiwan, over a period of 3 y. Case-patients included 16 men and 9 women, from 13 to 75 y. All had severe underlying diseases, most commonly malignancy (44%). Twenty-four patients (96%) had nosocomial infections. Five patients (20%) had polymicrobial bacteraemia. Our controls included 11 men and 14 women, age range 18-80 y. The most common underlying disease was malignancy ...
Objectives: In a prospective, randomized trial, daptomycin was non-inferior to standard therapy for Staphylococcus aureus bacteraemia and right-sided endocarditis. Since rates of infection due to methicillin-resistant S. aureus (MRSA) infection are increasing and treatment outcomes for bacteraemia caused by MRSA are generally worse than those observed with methicillin-susceptible S. aureus bacteraemia, clinical characteristics and treatment results in the trials pre-specified subset of patients with MRSA were analysed. Methods: Clinical characteristics and outcomes of patients receiving daptomycin were compared with those receiving vancomycin plus low-dose gentamicin. Success was defined as clinical improvement with clearance of bacteraemia among patients who completed adequate therapy, received no potentially effective non-study antibiotics and had negative blood cultures 6 weeks after end of therapy. Results: Twenty of the 45 (44.4%) daptomycin patients and 14 of the 43 (32.6%) ...
Objectives: To examine whether urgent orotracheal intubation (OI) can induce bacteremia. To find predictive factors for post-intubation b
Sánchez-Diener I1, Zamorano L2, Peña C3, Ocampo-Sosa A4, Cabot G1, Gómez-Zorrilla S5, Almirante B6, Aguilar M7, Granados A8, Calbo E9, Baño JR10, Rodríguez-López F11, Tubau F12, Martínez-Martínez L11, Navas A13, and Oliver A14. 1Servicio de Microbiología and Unidad de Investigación, Hospital Son Espases, Instituto de Investigación Sanitaria de les Illes Balears (IdISBa), Palma de Mallorca,…
There is no evidence supporting the use of de-escalation therapy (DET) among patients with community-acquired pneumonia (CAP). We assessed the outcomes associated with DET among bacteraemic CAP patients. We performed a secondary analysis of the Community-Acquired Pneumonia Organization database, which contains data on 660 bacteraemic patients hospitalized because of CAP in 35 countries (2001-2013). Exclusion criteria were death within 72h from admission and an inappropriate empirical antibiotic regimen. DET was defined as changing an appropriate empirical broad-spectrum regimen to a narrower-spectrum regimen according to culture results within 7 days from hospital admission. Two study groups were identified: patients whose antibiotic therapy was de-escalated (the DET group), and patients whose antibiotic therapy was not de-escalated (the N-DET group). The primary study outcome was 30-day mortality. Two hundred and sixty-one bacteraemic CAP patients were included. Gram-positive bacteria were ...
Abstract Prior antibiotic use, contamination, limited blood volume, and processing delays reduce yield of blood cultures for detection of Streptococcus pneumoniae. We performed immunochromatographic testing (ICT) on broth from incubated blood culture bottles and real-time lytA polymerase chain reaction (PCR) on broth and whole blood and compared findings to blood culture in patients with suspected bacteremia. We selected 383 patients in Mali and 586 patients in Thailand based on their blood culture results: 75 and 31 were positive for pneumococcus, 100 and 162 were positive for other pathogens, and 208 and 403 were blood culture negative, respectively. ICT and PCR of blood culture broth were at least 87% sensitive and 97% specific compared with blood culture; whole blood PCR was 75-88% sensitive and 96-100% specific. Pneumococcal yields in children < 5 years of age increased from 2.9% to 10.7% in Mali with > 99% of additional cases detected by whole blood PCR, and from 0.07% to 5.1% in Thailand
Intravenous literature: Previsdomini, M., Gini, M., Cerutti, B., Dolina, M. and Perren, A. (2012) Predictors of positive blood cultures in critically ill patients: a retrospective evaluation. Croatian Medical Journal. 53(1), p.30-9.. Abstract:. Aim - To identify predictors of bacteremia in critically ill patients, to evaluate the impact of blood cultures on the outcome, and to define conditions for breakthrough bacteremia despite concurrent antibiotic treatment.. Methods - A descriptive retrospective study was performed over a two-year period (2007-2008) in the medico-surgical Intensive Care Unit (ICU) of the San Giovanni Hospital in Bellinzona, Switzerland.. Results - Forty-five out of 231 patients (19.5%) had positive blood cultures. Predictors of positive blood cultures were elevated procalcitonin levels (,2 µg/L, P43, P=0.014; Sequential Organ Failure Assessment ,4.0, P38.5°C) only showed a trend toward a higher rate of blood culture positivity (P=0.053). The rate of positive blood ...
S. O. Heard, R. F. Davis, R. J. Sherertz, R. C. Gallagher, A. J. Layon, M. S. Mikhail, T. J. Gallagher; STERILITY OF PULMONARY ARTERY CATHETERS WITH STERILE PROTECTIVE SLEEVES AND THE INCIDENCE OF CATHETER-RELATED BACTEREMIA. Anesthesiology 1984;61(3):A154. Download citation file:. ...
Surveillance blood cultures are often obtained in hematopoietic stem cell transplant (HSCT) patients for detection of bloodstream infection. The major aims of this retrospective cohort study were to determine the utility of the practice of obtaining surveillance blood cultures from asymptomatic patients during the first 100 post-transplant days and to determine if obtaining more than one positive blood culture helps in the diagnosis of bloodstream infection. We conducted a 17-month retrospective analysis of all blood cultures obtained for patients admitted to the hospital for HSCT from January 2010 to June 2011. Each patients clinical course, vital signs, diagnostic testing, treatment, and response to treatment were reviewed. The association between number of positive blood cultures and the final diagnosis was analyzed. Blood culture results for 205 patients were reviewed. Cultures obtained when symptoms of infection were present (clinical cultures) accounted for 1,033 culture sets, whereas 2,474
http://www.mja.com.au/public/issues/191_07_051009/tur10849_fm.html. Objective: To document the types of, and mortality from, Staphylococcus aureus bacteraemia in Australia and New Zealand, and determine factors associated with mortality.. Design and setting: Prospective observational study in 27 independent or hospital pathology laboratories in Australia (24) and New Zealand (3), employing a web-based database to prospectively record demographic features, selected risk factors, principal antibiotic treatment and mortality data on all patients with positive blood cultures for S. aureus from June 2007 to May 2008.. Main outcome measure: 30-day all-cause mortality.. Results: 1994 episodes of S. aureus bacteraemia were identified, and complete 30-day follow-up data were available for 1865. Most episodes had their onset in the community (60.8%; 95% CI, 58.7%-63.0%). Methicillin-resistant S. aureus (MRSA) caused 450 episodes (24.1%; 95% CI, 22.2%-25.9%), and 123 of these (27.3%) had a susceptibility ...
Most of the studies evaluating the secular trends of blood isolates come from tertiary hospitals in urban areas. We sought to study the trends of the antimicrobial resistance of blood isolates in patients from a rural population hospitalized in a tertiary hospital in a small city in Greece. We retrospectively collected and analysed data for the first positive blood culture obtained for each admission for each patient hospitalized in General Hospital of Tripolis, Tripolis, Peloponnesus, Greece during a 5 year period (16/05/2000 - 15/05/2005). Sixty-seven thousand and seventy patients were hospitalized during the study period from whom 3,206 blood cultures were obtained. A higher increase of the number of obtained blood cultures than the number of admissions was noted during the study period (p | 0.001). Three hundred and seventy-three (11.6%) blood cultures were positive. Coagulase-negative staphylococci (35.9%), Escherichia coli (29%), and Staphylococcus aureus (18.2%) were the most commonly isolated
Introduction: Severe malnutrition is a common cause of preventable morbidity and mortality among children aged 5 years in developing countries. The prevalence of bacteraemia, urinary tract infection, diarrhea and pneumonia among children with severe malnutrition is high. These, coupled with an atypical clinical presentation of sepsis, justify the routine use of empirical antibiotic treatment in the initial phase of inpatient management of SAM children1 2 .The choice of antibiotics should be guided by locally prevalent pathogens and their antibiotic susceptibility patterns. Objectives: The broad objective of this study was to determine the prevalence of bacteraemia in SAM children at Mbagathi District Hospital and its association with the history and physical examination characteristics of the enrolled children. The primary objectives of the study were: • To determine the blood bacterial isolates in SAM children in Mbagathi District Hospital. • To determine the sensitivities of the bacterial ...
definition of NBMBRS, what does NBMBRS mean?, meaning of NBMBRS, National Bacterial Meningitis and Bacteremia Reporting System, NBMBRS stands for National Bacterial Meningitis and Bacteremia Reporting System
Osteomyelitis may occur as a result of a bacterial bloodstream infection, sometimes called bacteremia, or sepsis, that spreads to the bone. This type is most common in infants and children and usually affects their long bones such as the femur (thighbone) or humerus (upper arm bone). When osteomyelitis affects adults, it often involves the vertebral bones along the spinal column. The source of the blood infection is usually Staphylococcus aureus, although it may be caused by a different type of bacteria or fungal organism ...
Osteomyelitis may occur as a result of a bacterial bloodstream infection, sometimes called bacteremia, or sepsis, that spreads to the bone. This type is most common in infants and children and usually affects their long bones such as the femur (thighbone) or humerus (upper arm bone). When osteomyelitis affects adults, it often involves the vertebral bones along the spinal column. The source of the blood infection is usually Staphylococcus aureus, although it may be caused by a different type of bacteria or fungal organism ...
A national response to AMR in South Africa was articulated through development of a National Strategy Framework for AMR for the 2014-2024 period. One of the main strategic objectives is to optimize surveillance and early detection of AMR. Key responsibility for AMR surveillance is undertaken by NICD. NICD has developed two-tier surveillance reporting, one by laboratory-based surveillance for AMR (LARS) via GERMS-SA, and another by electronic surveillance (e-surveillance) from the corporate data warehouse supplying data from routine NHLS laboratories. These data reports are available on an NICD dashboard (www.nicd.ac.za). The Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses (CHARM) at NICD uses the GERMS-SA laboratory-based surveillance platform to conduct intermittent surveys for antimicrobial-resistant bacterial bloodstream infections, and reports are available on the NICD website.. The National Department of Health responded to the GLASS call for surveillance ...
TY - JOUR. T1 - Central venous catheter salvage in children with Staphylococcus aureus central line-associated bloodstream infection. AU - Corkum, Kristine S.. AU - Jones, Rachel E.. AU - Reuter, Caroline H.. AU - Kociolek, Larry K.. AU - Morgan, Elaine. AU - Lautz, Timothy B.. PY - 2017/11/1. Y1 - 2017/11/1. N2 - Background: Prompt central venous catheter (CVC) removal is currently recommended in children with Staphylococcus aureus central line-associated bloodstream infection (CLABSI). Our objective was to examine the outcome of attempted line salvage in children with S. aureus CLABSI and assess predictors of success. Methods: A single-institution, retrospective cohort study was performed of all children with S. aureus CLABSI between 2012 and 2015. Patients with and without immediate CVC removal (≤ 2 days after first positive culture) were compared. The primary outcome was failed CVC salvage (removal after 3+ days). Results: Seventy-seven children met criteria for S. aureus CLABSI. Immediate ...
Central line-associated bloodstream infections (CLABSI) fell by more than 90 percent during the past three years at the Hospital of the University of Pennsylvania due to a multi-pronged approach combining leadership initiatives, electronic infection surveillance, checklists to guide line insertion and maintenance, and implementation of the Toyota Production System to encourage best practices in line care. The findings, which Penn physicians say provide a road map for cutting the deadly, costly toll of hospital-acquired infections nationwide, were presented on Friday, March 20 at the 19th Annual Meeting of the Society for Healthcare Epidemiology of America (SHEA).
University of Helsinki, Faculty of Medicine, Institute of Clinical Medicine, Division of Infectious Diseases, Helsinki University Central Hospital. Lactobacilli are gram positive rods, which belong to normal oropharyngeal, gastrointestinal and urogenital flora. They are widely used in food industry and as food additives. Although their virulence is presumed to be very low, opportunistic bacteremic infections, especially in immunocompromised hosts, have been detected. In the present study, the possible effects of increasing probiotic use of Lactobacillus rhamnosus GG (LGG) on the occurrence of bacteremia due to lactobacilli was evaluated on population level. In Finland, 90 Lactobacillus bacteremia cases were reported to the National Infectious Disease Register maintained by National Public Health Institute, during 1995-2000. Their proportion of all bacteremia cases was on average 0.24%, corresponding to 0.3 cases/100 000 inhabitants annually. In the Helsinki University Central Hospital district ...
Controversy surrounds the role of central venous catheters (CVCs) impregnated with antimicrobial agents in the prevention of catheter-related bloodstream infection (CRBSI). We reviewed the current literature to evaluate the efficacy of antimicrobial-impregnated CVCs for preventing CRBSI. Eleven randomized studies published in article form were identified that included a control group that received nonimpregnated CVCs. We evaluated study methodologies, inclusion of key patient characteristics, use of clinically relevant end points, and molecular-relatedness studies. Review of these 11 trials revealed several methodological flaws, including inconsistent definitions of CRBSI, failure to account for confounding variables, suboptimal statistical and epidemiological methods, and rare use of clinically relevant end points. This review also failed to demonstrate any significant clinical benefit associated with the use of antimicrobial-impregnated CVCs for the purpose of reducing CRBSI or improving ...
ContextConcerns about rates of methicillin-resistant Staphylococcus aureus (MRSA) health care-associated infections have prompted calls for mandatory screening
As part of the National Action Plan to Prevent Healthcare-Associated Infections that was established in 2008, HHS has set goals for reducing central line-associated bloodstream infections, catheter-associated urinary tract infections, and surgical site infections by December 2013. The data included in this report indicate that steady progress is occurring towards the goal of a 50 percent reduction in central line-associated bloodstream infections and a 25 percent reduction goal for surgical site infections over the course of five years. Although progress towards the 25 percent reduction goal for catheter-associated urinary tract infections is moving more slowly, with sustained prevention efforts, the 2013 goal remains attainable ...
The aim of this clinical trial is to determine whether a novel combination antibiotic treatment (vancomycin/daptomycin + beta-lactam) is superior to the standard antibiotic treatment (vancomycin/daptomycin) for hospitalised adults with Methicillin Resistant Staphylococcus aureus bacteraemia. The hypothesis is that the addition of beta-lactam antibiotics (these are antibiotics from the penicillin family) to the standard therapy will lead to more efficient bacterial killing and hence lead to faster clearance of bacteria from the blood stream and other areas of infection, thereby reducing the risk of the spread of infection and death.. The study design is an investigator-initiated, multi-centre, open-label, randomised controlled trial. This will include 440 participants diagnosed with Methicillin Resistant Staphylococcus aureus bacteraemia recruited over a period of 4 years (July 2015 - June 2019) from within Infectious Diseases inpatient units across 21 hospital sites including 18 from within ...
The increased vancomycin minimum inhibitory concentration values (MICs) for methicillin-resistant Staphylococcus aureus (MRSA) isolates are associated with treatment failure and mortality of MRSA infections. In the present study, 553 non-duplicate MRSA isolates from various specimens of patients with infections at a Chinese tertiary hospital from January 2003 to December 2014, were selected randomly for investigating the shift of vancomycin MICs determined by E-test method. The percentages of the MRSA isolates with vancomycin MICs of ≥ 2.0 mg/L, 1.5 mg/L, 1.0 mg/L and ≤0.75 mg/L were 16.3% (90/553), 38.5% (213/553), 35.6% (197/553) and 9.9% (55/553), respectively. The highest geometric mean MIC (GM MIC) value (1.648 mg/L) and the lowest GM MIC (0.960 mg/L) were found in the first year (2003) and the last year (2014) over the study period, with significant difference (p

*Streptomyces bikiniensis

Moss, William J.; Sager, Jason A.; Dick, James D.; Ruff, Andrea (February 2003). "Bacteremia". Emerging Infectious Diseases. 9 ...

*Clostridium septicum

Leal, J; Gregson, DB; Ross, T; Church, DL; Laupland, KB (2008-06-19). "Epidemiology of Clostridium species bacteremia in ... Koransky, JR; Stargel, MD; Dowell, VR (1979). "Clostridium septicum bacteremia". The American Journal of Medicine. 66: 63-66. ...

*Cedecea

Farmer III, J. J., Sheth, N. K., Hudzinski, J. A., Rose, H. D., Asbury, M. F. (1982). Bacteremia due to Cedecea neteri sp. nov ... S.R. Perkins; T.A. Beckett; C.M. Bump (1986). "Cedecea davisae bacteremia". Journal of Clinical Microbiology. 24: 675-676. H. ... Abate,G., Qureshi, S., and Mazumder, S. A. (2011). Cedecea davisae bacteremia in a neutropenic patient with acute myeloid ... Perkins, S. R., Beckett, T. A., Bump, C. M. (1986). Cedecea davisae bacteremia. Journal of Clinical Microbiology 24, 675-676. ...

*Dietzia papillomatosis

"Dietzia papillomatosis Bacteremia". Journal of Clinical Microbiology. 51 (6): 1977-1978. doi:10.1128/JCM.03313-12. PMC 3716072 ...

*Microvirgula aerodenitrificans

"Recurrent Microvirgula aerodenitrificans Bacteremia". Journal of Clinical Microbiology. 50 (8): 2823-2825. doi:10.1128/JCM. ...

*Clostridium intestinale

Elsayed, S.; Zhang, K. (6 April 2005). "Bacteremia Caused by Clostridium intestinale". Journal of Clinical Microbiology. 43 (4 ... Clostridium intestinale can cause bacteremia. Parte, A.C. "Clostridium". www.bacterio.net. "Clostridium intestinale Taxon ...

*Campylobacter showae

"Campylobacter showae bacteremia with cholangitis". Journal of Infection and Chemotherapy. 19 (5): 960-963. doi:10.1007/s10156- ...

*Acinetobacter ursingii

March 2003). "Bacteremia caused by Acinetobacter ursingii". Journal of Clinical Microbiology. 41 (3): 1337-8. doi:10.1128/jcm. ...

*Esophageal dilatation

"Bacteremia associated with esophageal dilatation". J. Clin. Gastroenterol. 5 (2): 109-12. doi:10.1097/00004836-198304000-00003 ...

*Streptomyces thermovulgaris

Ekkelenkamp, Miquel Bart; de Jong, Wilma; Hustinx, Willem; Thijsen, Steven (October 2004). "Bacteremia in Crohn's Disease ...

*Sepsis

The modern term for this is bacteremia. By the end of the 19th century, it was widely believed that microbes produced ... "Bacteremia - Infections - Merck Manuals Consumer Version". The Merck Manuals. Archived from the original on 28 July 2017. ...

*George Siber bibliography

Siber, George R. (1 July 1980). "Bacteremias due to Haemophilus influenzae and Streptococcus pneumoniae". American Journal of ... Anderson, AB; Ambrosino, DM; Siber, GR (Jun 1987). "Haemophilus influenzae type b unsuspected bacteremia". Pediatric Emergency ... Pneumococcal antigen detection in children at risk for occult bacteremia. Pediatric Research 1985 (Abstract). Wright D, Siber G ...

*Streptococcus bovis

The main portal of entry for human infection of S. bovis bacteremia is the gastrointestinal tract, but in some cases, entry is ... 2012). "Association between Bacteremia Due to Streptococcus gallolyticus subsp. gallolyticus (Streptococcus bovis I) and ... White BA, Labhsetwar SA, Mian AN (November 2002). "Streptococcus bovis bacteremia and fetal death". Obstetrics and Gynecology. ...

*Chromobacterium violaceum

Chen, CH; Lin, LC; Liu, CE; Young, TG (2003). "Chromobacterium violaceum bacteremia: a case report". J Microbiol Immunol Infect ...

*Borrelia

Relapsing fever borreliosis often occurs with severe bacteremia.[8] B. recurrentis is transmitted by the human body louse; no ...

*Methicillin-resistant Staphylococcus aureus

... concluded that MRSA bacteremia is associated with increased mortality as compared with MSSA bacteremia (odds ratio= 1.93; 95% ... For bacteremia and endocarditis, vancomycin or daptomycin is considered. For children with MRSA infected bone or joints, ... Johnson AP, Pearson A, Duckworth G (2005). "Surveillance and epidemiology of MRSA bacteraemia in the UK". J Antimicrob ... Wyllie DH, Crook DW, Peto TE (2006). "Mortality after Staphylococcus aureus bacteraemia in two hospitals in Oxfordshire, 1997- ...

*Pseudomonas infection

1984). "Pseudomonas fluorescens bacteremia from blood transfusion". Am. J. Med. 76 (1): 62-8. doi:10.1016/0002-9343(84)90751-4 ... It can cause peritonitis, endophthalmitis, septicemia and bacteremia. Similar symptoms although also very rare can be seen by ...

*Bergeyella zoohelcum

ISBN 0-387-68572-3. Lin, Wei-Ru; Chen, Yao-Shen; Liu, Yung-Ching (2007). "Cellulitis and Bacteremia Caused by Bergeyella ... Chen, Yili; Liao, Kang; Ai, Lu; Guo, Penghao; Huang, Han; Wu, Zhongwen; Liu, Min (2017). "Bacteremia caused by Bergeyella ... ISBN 3-540-39005-7. Lin, Wei-Ru; Chen, Yao-Shen; Liu, Yung-Ching (2007). "Cellulitis and Bacteremia Caused by Bergeyella ...

*J. Morris Slemons

Slemons, J. Morris, M.D. (1915) Bacteremia. Journal of the American Medical Association, Vol LXV, No. 15: 1265-1268. Slemons, J ...

*Ischemic colitis

Bennion R, Wilson S, Williams R (1984). "Early portal anaerobic bacteremia in mesenteric ischemia". Arch Surg. 119 (2): 151-5. ...

*Bacteroides fragilis

It also causes bacteremia associated with intraabdominal infections, peritonitis and abscesses following rupture of viscus, and ... Bacteroides infections at eMedicine Brook I (June 2010). "The role of anaerobic bacteria in bacteremia". Anaerobe. 16 (3): 183- ...

*Bartonella quintana

All of these processes result in patients possessing systemic symptoms (chills, fever, diaphoresis), bacteremia, and lymphatic ... Brouqui, Philippe; Lascola, Bernard; Roux, Veronique; Raoult, Didier (1999). "Chronic Bartonella quintana Bacteremia in ... "A Newly Recognized Fastidious Gram-negative Pathogen as a Cause of Fever and Bacteremia". New England Journal of Medicine. 323 ...

*Acinetobacter lwoffii

Ku, SC; Hsueh, PR; Yang, PC; Luh, KT (July 2000). "Clinical and microbiological characteristics of bacteremia caused by ... Regalado, NG; Martin, G; Antony, SJ (September 2009). "Acinetobacter lwoffii: bacteremia associated with acute gastroenteritis ...

*Myroides

Endicott-Yazdani, Tiana R.; Dhiman, Neelam; Benavides, Raul; Spak, Cedric W. (1 July 2015). "Myroides odoratimimus bacteremia ...

*Haemophilus influenzae biogroup aegyptius

"Haemophilus aegyptius bacteremia in Brazilian purpuric fever." Lancet ii (1987): 761-3. Type strain of Haemophilus influenzae ... "International Notes Brazilian Purpuric Fever: Haemophilus aegyptius Bacteremia Complicating Purulent Conjunctivitis." Morbidity ...

*Clostridium sordellii

C. sordellii bacteremia and sepsis occur rarely. Most cases of sepsis from C. sordellii occur in patients with underlying ...

Streptococcus bovis bacteremia and colon cancer - My Med atlasStreptococcus bovis bacteremia and colon cancer - My Med atlas

Streptococcus bovis bacteremia and colon cancer. May 13, 2017. Did you know? That if a patient has Streptococcus bovis in their ... Posted in: Clinic, medicine, MS1 & MS2, Oh wow!, Study Stuff, Uncategorized , Tagged: bacteremia, bacteria, cancer, colon ...
more infohttps://mashamdtobe.wordpress.com/2017/05/13/streptococcus-bovis-bacteremia-and-colon-cancer/

BestBets: Role of antibiotic line locks in the treatment of infected central venous access devices in childrenBestBets: Role of antibiotic line locks in the treatment of infected central venous access devices in children

174 patients with bacteraemia and CVAD were recruited.46 patients found fit for final analysis, including 34 from haemato- ... Fortun J, Grill F, Martin-Davila P, et al.. Treatment of long-term intravascular catheter-related bacteremia with antibiotic- ... 10 children on chemotherapy for solid tumours with Gram positive bacteraemia. Prospective case series (level 4). Negative blood ... Venous access port-related bacteremia in patients with acquired immunodeficiency syndrome or cancer: the reservoir as a ...
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Bacteremia in neutropenic children.  - PubMed - NCBIBacteremia in neutropenic children. - PubMed - NCBI

Bacteremia in neutropenic children.. Siegel JD.. Comment on. *The changing epidemiology of bacteremia in neutropenic children ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/7567301?dopt=Abstract

Bacteremia due to Bordetella holmesii.  - PubMed - NCBIBacteremia due to Bordetella holmesii. - PubMed - NCBI

Bacteremia due to Bordetella holmesii.. Morris JT1, Myers M.. Author information. 1. Department of Medicine, Madigan Army ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/9798064?dopt=Abstract

Which Klebsiella pathogen may cause neonatal bacteremia?Which Klebsiella pathogen may cause neonatal bacteremia?

K oxytoca has been implicated in neonatal bacteremia, especially among premature infants and in neonatal intensive care units. ... Which Klebsiella pathogen may cause neonatal bacteremia?. Updated: Jun 10, 2019 * Author: Shahab Qureshi, MD, FACP; Chief ... Bodey GP, Elting LS, Rodriquez S, Hernandez M. Klebsiella bacteremia. A 10-year review in a cancer institution. Cancer. 1989 ... K oxytoca has been implicated in neonatal bacteremia, especially among premature infants and in neonatal intensive care units. ...
more infohttps://www.medscape.com/answers/219907-26388/2039975-overview

Epidemiology of Staphylococcus aureus bacteremia in adultsEpidemiology of Staphylococcus aureus bacteremia in adults

Staphylococcus aureusis a leading cause of community-acquired and healthcare-associated bacteremia. The annual incidence ofS. ... The annual incidence of S. aureus bacteremia (SAB) in the United States is 38.2 to 45.7 per 100,000 person-years [1,2]; ... Staphylococcus aureus bacteremia with reduced susceptibility to vancomycin. *Susceptibility to infections in persons with ... Epidemiology of Staphylococcus aureus bacteremia in adults. Authors. Thomas Holland, MD. Thomas Holland, MD ...
more infohttp://www.uptodate.com/contents/epidemiology-of-staphylococcus-aureus-bacteremia-in-adults

Bacteremia after injection of esophageal varices | SpringerLinkBacteremia after injection of esophageal varices | SpringerLink

Elective sclerotherapy for esophageal varices produces bacteremia in 4% to 53% of patients. The clinical importance of this ... Bacteremia appears to be an infrequent and transient event after elective sclerotherapy. Only patients with prosthetic heart ... Camara DS (1986) Bacteremia and injection sclerotherapy. Arch Intern Med 146: 458-459Google Scholar ... Snady H, Korsten MA, Waye JD (1985) The relationship of bacteremia to the length of injection needle in endoscopic variceal ...
more infohttps://link.springer.com/article/10.1007/BF00591406

Bacteremia in ChildrenBacteremia in Children

... , Fever Without Focus, Fever Without Source, Occult Bacteremia, Streptococcal Bacteremia, Serious ... Bacteremia in Children. Bacteremia in Children Aka: Bacteremia in Children, Fever Without Focus, Fever Without Source, Occult ... Associated Conditions: Occult Bacteremia underlying causes * Risk Factors: High risk conditions for Occult Bacteremia ... Associated Conditions: Occult Bacteremia underlying causes * Risk Factors: High risk conditions for Occult Bacteremia ...
more infohttps://fpnotebook.com/ID/Peds/BctrmInChldrn.htm

Which factor increases the risk of mortality from Enterobacter bacteremia?Which factor increases the risk of mortality from Enterobacter bacteremia?

In patients with Enterobacter bacteremia, the most important factor in determining the risk of mortality is the severity of the ... Enterobacter bacteremia in pediatric patients. Rev Infect Dis. 1990 Sep-Oct. 12(5):808-12. [Medline]. ... In patients with Enterobacter bacteremia, the most important factor in determining the risk of mortality is the severity of the ... Enterobacter bacteremia: Clinical features, risk factors for multiresistance and mortality in a Chinese University Hospital. ...
more infohttps://www.medscape.com/answers/216845-63064/226434-overview

Rapid, Culture-Free Detection of Staphylococcus aureus BacteremiaRapid, Culture-Free Detection of Staphylococcus aureus Bacteremia

Patients with suspected bacteremia must therefore be empirically treated, often unnecessarily, while assay results are pending ... aureus bacteremia. These results suggest that a nuclease-detecting assay may enable the rapid and inexpensive diagnosis of SAB ... aureus bacteremia (SAB) is a common condition with high rates of morbidity and mortality. Current methods used to diagnose SAB ...
more infohttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157234

Bacteremia Global Clinical Trials Review, H2, 2013: ReportstackBacteremia Global Clinical Trials Review, H2, 2013: Reportstack

To view the table of contents and know more details please visit Bacteremia Global Clinical Trials Review, H2, 2013 ... Reportstack has announced a new market research publication on Bacteremia Global Clinical Trials Review, H2, 2013 which ... of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Bacteremia. This ... provides elemental information and data relating to the clinical trials on Bacteremia. It includes an overview of the trial ...
more infohttps://pitchengine.com/pitches/ac80f3b5-2429-406e-a289-93fc455a2da4

Bacteremia related drugs by generic name | Drugs.comBacteremia related drugs by generic name | Drugs.com

Comprehensive Bacteremia information for consumers and professionals including user ratings, reviews and drug dosage ... Medications to treat Bacteremia. The following list of medications are in some way related to, or used in the treatment of this ... Looking for answers? Ask a question or go join the bacteremia support group to connect with others who have similar interests. ... What is Bacteremia: The presence of viable bacteria circulating in the bloodstream. ...
more infohttps://www.drugs.com/condition/bacteremia.html?include_rx=true&include_otc=true&show_off_label=true&only_generics=true&submitted=true

List of Bacteremia Medications (54 Compared) - Drugs.comList of Bacteremia Medications (54 Compared) - Drugs.com

Compare risks and benefits of common medications used for Bacteremia. Find the most popular drugs, view ratings, user reviews, ... Medications to treat Bacteremia. The following list of medications are in some way related to, or used in the treatment of this ... Looking for answers? Ask a question or go join the bacteremia support group to connect with others who have similar interests. ... What is Bacteremia: The presence of viable bacteria circulating in the bloodstream. ...
more infohttps://www.drugs.com/condition/bacteremia.html

Management of Staphylococcus aureus bacteremia in adults | CMAJManagement of Staphylococcus aureus bacteremia in adults | CMAJ

Criteria for uncomplicated bacteremia5. Patients have uncomplicated bacteremia if they satisfy all of the following:. *. ... About 10%-20% of patients with S. aureus bacteremia have infective endocarditis.4 All patients with S. aureus bacteremia should ... Infectious disease consultation for Staphylococcus aureus bacteremia - a systematic review and meta-analysis. J Infect 2016;72: ... Expert consultation is suggested for all patients with S. aureus bacteremia. *Initial antibiotic therapy for S. aureus ...
more infohttps://www.cmaj.ca/content/191/35/E967

Epidemiologic Notes and Reports
Group A Beta-Hemolytic Streptococcal Bacteremia -- Colorado, 1989Epidemiologic Notes and Reports Group A Beta-Hemolytic Streptococcal Bacteremia -- Colorado, 1989

While a direct comparison of the GABHS bacteremia incidence rate in Denver for 1989 and for previous years is not possible ... The descriptive epidemiology of GABHS bacteremia in the Denver patients is similar to that in previous reports (9,10). Even ... Factors contributing to the apparent recent increase in GABHS bacteremia are unclear. No single serotype, to suggest a common ... Epidemiologic Notes and Reports Group A Beta-Hemolytic Streptococcal Bacteremia -- Colorado, 1989 From January through August ...
more infohttps://www.cdc.gov/mmwr/preview/mmwrhtml/00001530.htm

Bacteremia  - Causes, Symptoms, Diagnosis, Treatment, PreventionBacteremia - Causes, Symptoms, Diagnosis, Treatment, Prevention

Blood cultures are used in diagnosis and antibiotics are used to treat bacteremia. ... Bacteremia is the presence of viable bacteria in the bloodstream. ... What are the Causes of Bacteremia?. Based on an analysis of bacteremia cases, it has been observed that bacteremia is a result ... How Do You Diagnose Bacteremia?. It is not easy to diagnose bacteremia. Having said this, the diagnosis of bacteremia is based ...
more infohttps://www.medindia.net/patientinfo/bacteremia.htm

Shewanella (Pseudomonas) putrefaciens bacteremia.Shewanella (Pseudomonas) putrefaciens bacteremia.

... putrefaciens bacteremia have ever been reported in the literature. In this retrospective study we describe 28 cases of S. ... Bacteremia / complications*. Gram-Negative Bacterial Infections / complications*. Gram-Negative Facultatively Anaerobic Rods / ... Polymicrobial bacteremia was seen in 18 cases. Three syndromes of bacteremic infection with S. putrefaciens appear to exist: ... In this retrospective study we describe 28 cases of S. putrefaciens bacteremia: 16 in premature and 1-day-old neonates, 9 in ...
more infohttp://www.biomedsearch.com/nih/Shewanella-Pseudomonas-putrefaciens-bacteremia/7620019.html

Staphylococcus aureus bacteremia in children: Epidemiology and clinical featuresStaphylococcus aureus bacteremia in children: Epidemiology and clinical features

... and healthcare-associated bacteremia.S. aureusbacteremia (SAB) is associated with increased morbidity and mortality, even with ... Staphylococcus aureus bacteremia in children: Management and outcome. *Staphylococcus aureus bacteremia with reduced ... Staphylococcus aureus is a leading cause of both community- and healthcare-associated bacteremia. S. aureus bacteremia (SAB) is ... Staphylococcus aureus bacteremia in children: Epidemiology and clinical features. Authors. Vance G Fowler, Jr, MD. Vance G ...
more infohttps://www.uptodate.com/contents/staphylococcus-aureus-bacteremia-in-children-epidemiology-and-clinical-features

Pulmonary abscess with bacteremia in a young man | CMAJPulmonary abscess with bacteremia in a young man | CMAJ

Pulmonary abscess with bacteremia in a young man. Markus G. Engelmann, Sigrid Nikol and Claus Vogelmeier ...
more infohttps://www.cmaj.ca/content/171/3/233

Plus itPlus it

Pneumococcal bacteraemia in mother and son. Br Med J (Clin Res Ed) 1983; 287 :529 ... Pneumococcal bacteraemia in mother and son.. Br Med J (Clin Res Ed) 1983; 287 doi: https://doi.org/10.1136/bmj.287.6391.529-a ( ...
more infohttp://www.bmj.com/content/287/6391/529.2

Bacteremia Rate Drops in Dialysis With Common Antibiotic | Medpage TodayBacteremia Rate Drops in Dialysis With Common Antibiotic | Medpage Today

Catheter-related bacteremia-free survival was significantly greater with minocycline-EDTA, and the two groups had similar rates ... Catheter-related bacteremia represents a major source of morbidity and mortality among dialysis patients. For example, one ... A catheter-lock solution of minocycline and EDTA led to a catheter-related bacteremia rate of 1 per 1,000 catheter days, a ... The minocycline-EDTA arm had a 90-day catheter-related bacteremia survival of 91.3% compared with 69.3% in the heparin group. ...
more infohttps://www.medpagetoday.com/nephrology/esrd/28135

STAPHYLOCOCCUS AUREUS BACTERAEMIA = BACTÉRIÉMIE À STAPHYLOCOCCUS AUREUSSTAPHYLOCOCCUS AUREUS BACTERAEMIA = BACTÉRIÉMIE À STAPHYLOCOCCUS AUREUS

1975)‎. STAPHYLOCOCCUS AUREUS BACTERAEMIA = BACTÉRIÉMIE À STAPHYLOCOCCUS AUREUS. Weekly Epidemiological Record = Relevé ...
more infohttp://apps.who.int/iris/handle/10665/220421

What Is the Connection between Bacteremia and Pneumonia?What Is the Connection between Bacteremia and Pneumonia?

Bacteremia and pneumonia are connected because pneumonia is a major cause of bacteremia. Although bacteremia and pneumonia are ... The primary connection between bacteremia and pneumonia is the fact that pneumonia is a major cause of bacteremia. This is ... Bacteremia and pneumonia are linked because if pneumonia gets out of hand, it can lead to a more serious infection of the blood ... Bacteremia usually does not take place unless the infection of the lungs grows out of control. This can be prevented with ...
more infohttp://www.wisegeek.com/what-is-the-connection-between-bacteremia-and-pneumonia.htm
  • PFGE performed with all 13 available isolates from recurrent cases showed that 10 were identical to that of the initial episode, including 1 in a patient with recurrence of S. canis bacteremia. (thefreelibrary.com)
  • We evaluated the epidemiological and clinical characteristics of patients with bacteremias caused by HLGR and non_HLGR Enterococcus faecalis isolates at a teaching hospital in the State of São Paulo, Brazil. (scielo.br)
  • We identified 145 cases of E. faecalis bacteremia: 66 (45.5%) were caused by HLGR isolates and 79 (54.5%) by non_HLGR. (scielo.br)
  • equisimilis and S. pyogenes bacteremic isolates and the relation of emm types to the severity of bacteremia. (coronetbooks.com)
  • To investigate the epidemiology and genetic structure of Staphylococcus aureus bacteremia in China, a total of 416 isolates from 22 teaching hospitals in 12 cities from 2013 and 2016 were characterized by antibiogram analysis, multilocus sequence typing (MLST), spa typing and staphylococcal cassette chromosome mec (SCC mec ) typing. (frontiersin.org)
  • The aim of the study was to determine the clinical manifestations, outcome of and prognostic factors associated with Pseudomonas aeruginosa bacteraemia at Chris Hani Baragwanath Hospital, Johannesburg, during the period 1998 -1999, to describe and quantify resistance to antipseudomonal drugs, to characterise bacteraemic isolates, and to investigate the clustering and genotype distribution of drug-susceptible and multiply-resistant strains in the hospital. (scielo.org.za)
  • Among the 9 patients with recurrent bacteremia, the causative agent was S. dysgalactiae subsp, equisimilis for 8 and S. canis for 1. (thefreelibrary.com)
  • Recurrent Bordetella holmesii bacteremia and nasal carriage in a patient receiving Rituximab. (thefreelibrary.com)
  • To the Editor: We report a case of recurrent Bordetella holmesii bacteremia with 4 clinical manifestations: 3 episodes of cellulitis and 1 episode of pneumonia. (thefreelibrary.com)
  • RF spirochetes remain predominantly localized in the blood, where they cause recurrent episodes of high-level bacteremia. (pubmedcentralcanada.ca)
  • equisimilis strains and strains isolated from patients with recurrent GGS bacteremia were characterized using pulsed field gel electrophoresis (PFGE). (coronetbooks.com)
  • We concluded that an endovascular stent that can not be removed makes management of recurrent bacteremia difficult. (scielo.br)
  • The aim of this study was to describe the clinical features of the author's cases of E. Lenta bacteraemia, and further define their microbiological characteristics using modern microbiological techniques. (selectscience.net)
  • Including only febrile infants may miss cases of bacteremia occurring in hypothermic or euthermic but ill-appearing infants. (aappublications.org)
  • Remember that septicemia and bacteremia are not the same thing, although they are similar, and are often used interchangeably. (petmd.com)
  • Here is what you should know about the symptoms, causes, and treatments for septicemia and bacteremia in dogs. (dogtime.com)
  • The symptoms of septicemia and bacteremia in dogs can appear suddenly or develop slowly over time. (dogtime.com)
  • If you see the following signs of septicemia and bacteremia in your dog, get to your veterinarian right away. (dogtime.com)
  • Treatment for septicemia and bacteremia in dogs often begins with emergency support, as septicemia can easily be fatal. (dogtime.com)
  • What Is the Connection between Bacteremia and Pneumonia? (wisegeek.com)
  • Treatment of bacteremia and pneumonia usually involves the use of powerful antibiotic medications. (wisegeek.com)
  • Bacteremia and pneumonia can both be fatal if not caught and treated early. (wisegeek.com)
  • In addition, during 1989, CDC received an increased number of reports of GABHS bacteremia from other areas in the United States and serotyped strains from several Scandinavian countries that have increased rates of GABHS bacteremia. (cdc.gov)
  • Early treatment of bacteremia with an appropriate antimicrobial regimen appears to improve survival. (merckmanuals.com)
  • Identifying patients at risk of ARP bacteraemia would help in deciding appropriate empiric antimicrobial therapy. (ersjournals.com)
  • Active surveillance for GABHS bacteremia was established in September 1989 in metropolitan Denver. (cdc.gov)
  • Design Prospective study in a London dialysis unit of the implementation and applicability of a dialysis associated bacteraemia surveillance scheme developed in the United States and its effect on bacteraemia, antibiotic usage, and admission. (bmj.com)
  • Selective digestive decontamination reduces bacteremia follo. (lww.com)
  • Previously, we showed that B cell-deficient mice persistently infected with Borrelia turicatae produce high levels of IL-10 and that exogenous IL-10 reduces bacteremia. (pubmedcentralcanada.ca)
  • BACKGROUND Bacteremia in young infants has remained an important ongoing concern for decades. (aappublications.org)
  • There were no cases of Listeria monocytogenes bacteremia or meningococcemia and only 1 case of enterococcal bacteremia. (aappublications.org)
  • The previously published NOVA score can identify patients with enterococcal bacteremia at risk for IE and we aimed to improve the score. (springer.com)
  • During the last 2 decades, Gram-negative rod bacteremia has become the leading infectious disease problem in American hospitals. (annals.org)
  • In Finland, 90 Lactobacillus bacteremia cases were reported to the National Infectious Disease Register maintained by National Public Health Institute, during 1995-2000. (helsinki.fi)
  • Shewanella (Pseudomonas) putrefaciens bacteremia. (biomedsearch.com)
  • Shewanella (Pseudomonas) putrefaciens is a rare pathogen in humans, and to our knowledge only 13 cases of S. putrefaciens bacteremia have ever been reported in the literature. (biomedsearch.com)
  • A. Heydari and M. Mojtabavi, "Bacteremia with Cutaneous Nodules, Due to Pseudomonas Aeruginosa," Advances in Infectious Diseases , Vol. 1 No. 2, 2011, pp. 27-28. (scirp.org)
  • No association was found between emm type, underlying diseases and disease manifestations of S. pyogenes bacteremia. (coronetbooks.com)
  • In this article, we report the largest cohort of patients with E. lenta bacteremia to date and describe in detail their clinical features, microbiologic characteristics, treatment, and outcomes. (asm.org)
  • Bacteraemia due to flossing: a cohort study. (nih.gov)