Babesia microti. Medical search

A species of protozoa infecting humans via the intermediate tick vector IXODES scapularis. The other hosts are the mouse PEROMYSCUS leucopus and meadow vole MICROTUS pennsylvanicus, which are fed on by the tick. Other primates can be experimentally infected with Babesia microti.

A genus of tick-borne protozoan parasites that infests the red blood cells of mammals, including humans. There are many recognized species, and the distribution is world-wide.

A group of tick-borne diseases of mammals including ZOONOSES in humans. They are caused by protozoa of the genus BABESIA, which parasitize erythrocytes, producing hemolysis. In the U.S., the organism's natural host is mice and transmission is by the deer tick IXODES SCAPULARIS.

A species of protozoa that is a cause of bovine babesiosis. Ticks of the genera Boophilus, Rhipicephalus, and IXODES are the chief vectors.

The largest genus of TICKS in the family IXODIDAE, containing over 200 species. Many infest humans and other mammals and several are vectors of diseases such as LYME DISEASE, tick-borne encephalitis (ENCEPHALITIS, TICK-BORNE), and KYASANUR FOREST DISEASE.

Members of the class Arachnida, especially SPIDERS; SCORPIONS; MITES; and TICKS; which transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.

Bacterial, viral, or parasitic diseases transmitted to humans and animals by the bite of infected ticks. The families Ixodidae and Argasidae contain many bloodsucking species that are important pests of man and domestic birds and mammals and probably exceed all other arthropods in the number and variety of disease agents they transmit. Many of the tick-borne diseases are zoonotic.

A species of gram-negative bacteria in the genus ANAPLASMA, family ANAPLASMATACEAE, formerly called Ehrlichia phagocytophila or Ehrlichia equi. This organism is tick-borne (IXODES) and causes disease in horses and sheep. In humans, it causes human granulocytic EHRLICHIOSIS.

The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)

Deoxyribonucleic acid that makes up the genetic material of protozoa.

The immature stage in the life cycle of those orders of insects characterized by gradual metamorphosis, in which the young resemble the imago in general form of body, including compound eyes and external wings; also the 8-legged stage of mites and ticks that follows the first moult.

Arthropods, other than insects and arachnids, which transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.

A tick-borne disease characterized by FEVER; HEADACHE; myalgias; ANOREXIA; and occasionally RASH. It is caused by several bacterial species and can produce disease in DOGS; CATTLE; SHEEP; GOATS; HORSES; and humans. The primary species causing human disease are EHRLICHIA CHAFFEENSIS; ANAPLASMA PHAGOCYTOPHILUM; and Ehrlichia ewingii.

Blood-sucking acarid parasites of the order Ixodida comprising two families: the softbacked ticks (ARGASIDAE) and hardbacked ticks (IXODIDAE). Ticks are larger than their relatives, the MITES. They penetrate the skin of their host by means of highly specialized, hooked mouth parts and feed on its blood. Ticks attack all groups of terrestrial vertebrates. In humans they are responsible for many TICK-BORNE DISEASES, including the transmission of ROCKY MOUNTAIN SPOTTED FEVER; TULAREMIA; BABESIOSIS; AFRICAN SWINE FEVER; and RELAPSING FEVER. (From Barnes, Invertebrate Zoology, 5th ed, pp543-44)

Infestations with soft-bodied (Argasidae) or hard-bodied (Ixodidae) ticks.

A genus of the subfamily SIGMODONTINAE consisting of 49 species. Two of these are widely used in medical research. They are P. leucopus, or the white-footed mouse, and P. maniculatus, or the deer mouse.

Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).

A genus of gram-negative, anaerobic, helical bacteria, various species of which produce RELAPSING FEVER in humans and other animals.

An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.

Constituent of the 40S subunit of eukaryotic ribosomes. 18S rRNA is involved in the initiation of polypeptide synthesis in eukaryotes.

Compounds consisting of benzene rings linked to each other in either ortho, meta or para positions. Permitted are any substitutions, but ring fusion to any of the benzene rings is not allowed.

Infections with bacteria of the genus BORRELIA.

Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.

A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.

Substances that are destructive to protozoans.

Any of several Old World finches of the genus Serinus.

The promotion and maintenance of physical and mental health in the work environment.

Surgical procedure involving either partial or entire removal of the spleen.

The branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions.

A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).

A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.

The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.

Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.

One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.

Gram-negative helical bacteria, in the genus BORRELIA, that are the etiologic agents of LYME DISEASE. The group comprises many specific species including Borrelia afzelii, Borellia garinii, and BORRELIA BURGDORFERI proper. These spirochetes are generally transmitted by several species of ixodid ticks.

A widely distributed genus of TICKS, in the family IXODIDAE, including a number that infest humans and other mammals. Several are vectors of diseases such as TULAREMIA; ROCKY MOUNTAIN SPOTTED FEVER; COLORADO TICK FEVER; and ANAPLASMOSIS.

A class of Arthropoda that includes SPIDERS; TICKS; MITES; and SCORPIONS.

The geographic area of the midwestern region of the United States in general or when the specific state or states are not indicated. The states usually included in this region are Illinois, Indiana, Iowa, Kansas, Kentucky, Michigan, Minnesota, Missouri, Nebraska, Ohio, Oklahoma, North Dakota, South Dakota and Wisconsin.

Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.

Genotypic differences observed among individuals in a population.

Roles of the Maltese cross form in the development of parasitemia and protection against Babesia microti infection in mice. (1/65)

Babesia microti, a hemoprotozoan parasite of rodents, is also important as a zoonotic agent of human babesiosis. The Maltese cross form, which consists of four masses in an erythrocyte, is characteristic of the developmental stage of B. microti. Monoclonal antibody (MAb) 2-1E, which specifically recognizes the Maltese cross form of B. microti, has been described previously. In the present study, we examined the roles of the Maltese cross form during the infectious course of B. microti in mice. The number of the Maltese cross form increased in the peripheral blood of infected mice prior to the peak of parasitemia. With confocal laser scanning microscopy, MAb 2-1E was found to be reactive with the ring form, with the parasites undergoing transformation to the Maltese cross form and subsequent division, and also with extracellular merozoites. Furthermore, the Maltese cross form-related antigen (MRA) gene was isolated from a B. microti cDNA library by immunoscreening with MAb 2-1E, and the nucleotide sequence was determined. Genomic analyses indicated that the MRA gene exists as a single-copy gene in B. microti. Immunization of mice with recombinant MRA induced significant protective immunity against B. microti infection. These findings indicate that the Maltese cross form plays important roles in both the development of parasitemia and the protective response against the infection. (+info)

The prevalence of piroplasms in a population of Ixodes ricinus (Acari: Ixodidae) from north-western Poland. (2/65)

Developmental forms of Babesia spp. were studied in isolated salivary glands of Ixodes ricinus, subjected to the Feulgen reaction. The same ticks were also hosts to Babesia microti, which was determined by PCR amplification with primers specific to the fragment of a gene encoding the nuclear small sub-unit ribosomal RNA (SS-rDNA). Presence of Babesia spp. was recorded in the salivary glands of 59.9% of ticks collected, both in nymphs and adults. PCR reactions specific to Babesia microti were positive in 1.9% of nymphs. (+info)

Transfusion-associated babesiosis after heart transplant. (3/65)

We describe a 54-year-old spleen-intact man with transfusion-associated Babesia microti infection after a heart transplant. Adult respiratory distress syndrome developed in the patient, and he required mechanical ventilation. Our experiences with this patient suggest that babesiosis should be considered in the differential diagnosis of transplant patients who have fever and hemolytic anemia. (+info)

Identification and characterization of putative secreted antigens from Babesia microti. (4/65)

The need for improved diagnostic reagents to identify human long-term carriers of the zoonotic parasite Babesia microti is evidenced by numerous reported cases of transfusion-acquired infections. This report describes the identification and initial characterization of 27 clones representing seven genes or gene families that were isolated through serological expression cloning by using a technique that we specifically designed to screen for shed antigens. In this screen, sera from B. microti-infected SCID mice, putatively containing secreted or shed antigens from the parasites, were harvested and used to immunize syngeneic immunocompetent mice (BALB/c). After boosting, the sera from the BALB/c mice, containing antibodies against the immunodominant secreted antigens, were used to screen a B. microti genomic expression library. Analyses of the putative peptides encoded by the novel DNA sequences revealed characteristics indicating that these peptides might be secreted. Initial serological data obtained with recombinant proteins and a patient serum panel demonstrated that several of the proteins could be useful in developing diagnostic tests for detection of B. microti antibodies and antigens in serum. (+info)

Increasing health burden of human babesiosis in endemic sites. (5/65)

Human infection due to Babesia microti has been regarded as infrequent and a condition primarily affecting the elderly or immunocompromised. To determine whether risk in endemic sites may be increasing relative to that of Borrelia burgdorferi and to define its age-related clinical spectrum, we carried out a 10-year community-based serosurvey and case finding study on Block Island, Rhode Island. Less intensive observations were conducted in nearby sites. Incidence of babesial infection on Block Island increased during the early 1990s, reaching a level about three-fourths that of borrelial infection. The sera of approximately one-tenth of Block Island residents reacted against babesial antigen, a seroprevalence similar to those on Prudence Island and in southeastern Connecticut. Although the number and duration of babesial symptoms in people older than 50 years of age approximated those in people 20 to 49 years of age, more older adults were admitted to hospital than younger adults. Few Babesia-infected children were hospitalized. Babesial incidence at endemic sites in southern New England appears to have risen during the 1990s to a level approaching that due to borreliosis. (+info)

Age-associated decline in resistance to Babesia microti is genetically determined. (6/65)

BACKGROUND: Although infection by the protozoan Babesia microti is rarely symptomatic in immunocompetent young people, healthy individuals aged >50 years may experience life-threatening disease. To determine the basis for this age relationship, we developed a mouse model of babesiosis using a novel clinical isolate of B. microti. METHODS: Mice were infected at 2, 6, 12, or 18 months. Parasitemia was monitored on Giemsa-stained blood smears or by flow cytometry. RESULTS: In DBA/2 mice, early and persistent parasitemias increased with age at infection. BALB/c and C57BL/6 mice were resistant, regardless of age, which indicates that allelic variation determines resistance to B. microti. Unlike immunocompetent mice, SCID mice, which retain an innate immune system but lack the lymphocytes needed for adaptive immunity, developed high and persistent levels of parasitemia that were markedly reduced by transfer of naive BALB/c or DBA/2 splenocytes. BALB/c cells reduced the persistent parasitemia to a greater extent than did age-matched DBA/2 cells. Of importance, there was an age-associated loss of protection by cells of both strains. CONCLUSION: The resistance to B. microti infection conferred by the adaptive immune system is genetically determined and associated with age. We postulate that there are age-related differences in the expression of alleles critical for adaptive immunity to B. microti. (+info)

Survey of rodents and ticks in human babesiosis emergence area in Japan: first detection of Babesia microti-like parasites in Ixodes ovatus. (7/65)

Babesia microti-like parasites were detected for the first time in Ixodes ovatus in Hyogo Prefecture, Japan, where two reported types of B. microti-like parasites were recognized in many rodents. Of 80 adult I. ovatus ticks collected, 5 possessed the reported type and 1 possessed a new type of B. microti-like parasite. (+info)

Prevalence of Borrelia burgdorferi, Bartonella spp., Babesia microti, and Anaplasma phagocytophila in Ixodes scapularis ticks collected in Northern New Jersey. (8/65)

PCR analysis of Ixodes scapularis ticks collected in New Jersey identified infections with Borrelia burgdorferi (33.6%), Babesia microti (8.4%), Anaplasma phagocytophila (1.9%), and Bartonella spp. (34.5%). The I. scapularis tick is a potential pathogen vector that can cause coinfection and contribute to the variety of clinical responses noted in some tick-borne disease patients. (+info)

Organism: Babesia microti, B. equi. *Vector: I. scapularis, I. pacificus. *Region (US): Northeast, West Coast ...

https://en.wikipedia.org/wiki/Tick-borne_disease

April 1994). "Diagnosis of babesiosis: evaluation of a serologic test for the detection of Babesia microti antibody". J. Infect ... In nonhuman animals, Babesia canis rossi, Babesia bigemina, and Babesia bovis cause particularly severe forms of the disease, ... Babesia canis and B. bigemina are "large Babesia species" that form paired merozoites in the erythrocytes, commonly described ... "Detection of Babesia microti by polymerase chain reaction". J. Clin. Microbiol. 30 (8): 2097-103. PMC 265450. PMID 1500517.. ...

https://en.wikipedia.org/wiki/Babesiosis

... microti/latest_assembly_versions/GCF_000691945.2_ASM69194v2". ftp.ncbi.nih.gov. Retrieved 2020-12-31. "Babesia microti (ID ... Check date values in: ,date= (help) "Index of /genomes/refseq/protozoa/Babesia_ ...

https://en.wikipedia.org/wiki/Gene_density

Babesia microti is transmitted by ixodes ticks. There are few studies which documents transmission of babesiosis through blood ... isolation of Babesia microti-like parasites with hu-RBC-SCID mice. "UK buys "safe" blood supply for NHS". British Broadcasting ...

https://en.wikipedia.org/wiki/Transfusion_transmitted_infection

The mitochondrial genome of Babesia microti is circular. This species is also now known not to belong to either of the genera ... "Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti". Nucleic Acids Res. 40 (18): 9102-14. ... Babesia or Theileria and a new genus will have to be created for it. Alveolata comprises around 9 major and minor groups, which ...

https://en.wikipedia.org/wiki/Alveolate

"Experimental transmission of Babesia microti by Rhipicephalus haemaphysaloides". Li et al. Parasites & Vectors. Retrieved 11 ...

https://en.wikipedia.org/wiki/Rhipicephalus_haemaphysaloides

"Sexuality in piroplasms as revealed by electron microscopy in Babesia microti". Proc. Natl. Acad. Sci. U.S.A. 80 (10): 2966-70 ... They include the tick parasites Babesia and Theileria. They are minute rounded or pyriform parasites found within erythrocytes ...

https://en.wikipedia.org/wiki/Piroplasmida

"The role of Ixodes trianguliceps tick larvae in circulation of Babesia microti in the Middle Urals". Entomological Review. 91 ( ...

https://en.wikipedia.org/wiki/Ixodes_trianguliceps

... independent of concurrent infection with Babesia microti". Parasitology. 108 (4): 413-419. doi:10.1017/s003118200007596x. PMID ... Development of Babesia in the tick is complex and includes sexual reproduction. These Babesia are transmitted from adult female ... against Babesia bigemina and Babesia argentina infections". American Journal of Veterinary Research. 34 (9): 1153-61. PMID ... Other species of Babesia are transmitted by three-host ticks in ways similar to Theileria protozoa, as described below. In ...

https://en.wikipedia.org/wiki/Ticks_of_domestic_animals

HyunJoo, Park (2015). "Characterizations of individual mouse red blood cells parasitized by Babesia microti using 3-D ... The invasion of babesia parasites to red blood cells were also studied. Toxoplasma gondii, apicomplexan parasite causing ...

https://en.wikipedia.org/wiki/Holotomography

Mitchell, PD; Reed, KD; Hofkes, JM (1996). "Immunoserologic evidence of coinfection with Borrelia burgdorferi, Babesia microti ...

https://en.wikipedia.org/wiki/Coinfection

... both in hamsters for Babesia microti and in gerbils for Babesia divergens. They now use faster diagnostic measures. ...

https://en.wikipedia.org/wiki/Xenodiagnosis

Parasites which have been studied by infecting Syrian hamsters with them include Toxoplasma gondii, Babesia microti, Leishmania ...

https://en.wikipedia.org/wiki/Laboratory_Syrian_hamster

Until 2006 T. microti was thought to belong to the genus Babesia, as Babesia microti, until ribosomal RNA comparisons placed it ... The genome of Theileria microti (aka Babesia microti) has been sequenced and published 2012. It shows that the species does not ... As of 2012[update], the medical community still classified the parasite as Babesia microti though its genome showed it does not ... Theileria microti is a parasitic blood-borne piroplasm transmitted by deer ticks. T. microti is responsible for the disease ...

https://en.wikipedia.org/wiki/Theileria_microti

... babesia MeSH B01.500.841.075.600.580.070.100 - babesia bovis MeSH B01.500.841.075.600.580.070.550 - babesia microti MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(B01)

... and Babesia microti, the causative agent of babesiosis. Although infection can cause some similar symptoms including fever, ...

https://en.wikipedia.org/wiki/Borrelia_miyamotoi

... the microbiological community changed the name Babesia microti to Theileria microti based on evidence from 2006. The sequence ... There are 15 avian species of Babesia, and four Babesia have been reported from sea hosts. Babesia poelea was described from ... Many species of Babesia only infect nonhuman mammalian hosts, most commonly cattle, horses, and sheep. B. microti and B. ... The genome of B. microti has been sequenced and shows that the species does not belong to either Babesia or Theileria, but ...

https://en.wikipedia.org/wiki/Babesia

Approval Letter -Babesia microti AFIA/Babesia microti AFIA for Blood Donor Screening (PDF) (Report). Nicole Verdun (Review ... microti was thought to belong to the genus Babesia, as Babesia microti, until ribosomal RNA comparisons placed it in the sister ... Babesia microti is a parasitic blood-borne piroplasm transmitted by deer ticks. B. microti is responsible for the disease ... The genome of Babesia microti has been sequenced and published. The mitochondrial genome is circular. In May 2010, it was ...

https://en.wikipedia.org/wiki/Babesia_microti

Hard-bodied ticks of the genus Ixodes are the main vectors of Lyme disease (also the vector for Babesia). Most infections are ... Ticks that transmit B. burgdorferi to humans can also carry and transmit several other parasites, such as Theileria microti and ...

https://en.wikipedia.org/wiki/Lyme_disease

https://en.wikipedia.org/wiki/Babesia_microti

Quantitated genomic DNA from Babesia microti strain Gray (ATCC ® 30221™) Isolation: ... Quantitative Babesia microti Genomic DNA is total DNA isolated from hamsters infected with the organism Babesia microti.. ATCC® ... Babesia microti (Franca) Reichenow (ATCC® 30221D™) Strain Designations: Quantitated genomic DNA from Babesia microti strain ... Development of droplet digital PCR for the detection of Babesia microti and Babesia duncani. Exp. Parasitol. 149: 24-31, 2015. ...

https://atcc.org/en/Global/Products/F/1/A/7/30221D.aspx

Babesia microti. B. microti is transmitted to humans primarily through the bite of Ixodes scapularis ticks, which are vectors ... Other routes of B. microti transmission are blood transfusion and in rare cases of mother-to-foetus transmission, through the ... This review discusses the current literature on mammalian coinfection with B. microti and Borrelia burgdorferi, the causative ... Babesia microti. B. microti is transmitted to humans primarily through the bite of Ixodes scapularis ticks, which are vectors ...

https://www.mdpi.com/2076-0817/8/3/117/xml

Although Babesia microti has been detected in ticks from Switzerland, few if any cases of babesiosis have been caused by B. ... microti. This first reported case, diagnosed by serology, DNA de … ... The majority of babesia infections in Europe are life-threatening and caused by Babesia divergens and B. bovis. ... Babesia microti infection in Europe Curr Microbiol. 2004 Jun;48(6):435-7. doi: 10.1007/s00284-003-4238-7. ...

https://pubmed.ncbi.nlm.nih.gov/15170239/

Cross-reactivity may occur with other human pathogenic species, such as Babesia duncani (WA-1), Babesia divergens, and Babesia ... This test is intended to detect Babesia microti, the primary etiologic agent of human babesiosis in the United States. ... This test is intended to be used as an aid in the diagnosis of Babesia microti infection. ...

https://www.labcorp.com/test-menu/20681/

Co-infections with the tick-transmitted pathogens Babesia microti and Borrelia burgdorferi sensu stricto are becoming a serious ... Infection of C3H/HeJ mice with B. burgdorferi and B. microti individually results in inflammatory Lyme disease and display of ... Infection of C3H/HeJ mice with B. burgdorferi and B. microti individually results in inflammatory Lyme disease and display of ... Testing of donated blood for Babesia species is not currently mandatory due to unavailability of an FDA approved test. ...

https://www.frontiersin.org/articles/10.3389/fmicb.2019.01596/full

... microti on each pathogen, immune response and on disease manifestations with respect to infection by the spirochete and the ... Babesia microti is transmitted by species of Ixodes, the same ticks that transmit the Lyme disease-causing spirochete, Borrelia ... Protozoan Parasite Babesia microti Subverts Adaptive Immunity and Enhances Lyme Disease Severity. *. ... the protozoan parasite Babesia microti (babesiosis); and multiple bacterial disease agents including Anaplasma phagocytophilum ...

https://medworm.com/709575293/protozoan-parasite-babesia-microti-subverts-adaptive-immunity-and-enhances-lyme-disease-severity/

Enzootic Babesia microti in Maine. Journal of Parasitology. 89(5):1069-71, 2003 Oct. ... Survey of rodents and ticks in human babesiosis emergence area in Japan: first detection of Babesia microti-like parasites in ... Ixodes ricinus as a vector of Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in urban and ... Browse by Exposure: Babesia microti (4 articles). % of records by year: 1965 2017 ...

http://canarydatabase.org/browse/exposure/4574

Infection with Babesia microti has not been well-described in eastern Pennsylvania, USA, despite the vector of this organism ... Seroprevalence of Babesia microti in blood donors from Babesia-endemic areas of the northeastern United States: 2000 through ... Human Babesia microti incidence and Ixodes scapularis distribution, Rhode Island, 1998-2004. Emerg Infect Dis. 2007;13:633-5. ... Infection with Babesia microti has not been well-described in eastern Pennsylvania, USA, despite the vector of this organism ...

http://wwwnc.cdc.gov/eid/article/19/7/12-1593_article.htm

Transfusion-transmitted Babesia spp.: bulls-eye on Babesia microti. Clin. Microbiol. Rev. 24: 14-28. ... microti infection and fatal infection with the Babesia WA1 strain showed an association of IL-10 production with B. microti ... Elimination of Babesia microti Is Dependent on Intraerythrocytic Killing and CD4+ T Cells. Sini Skariah, Paul Arnaboldi, ... Screening for Babesia microti in the U.S. blood supply. N. Engl. J. Med. 375: 2236-2245. ...

https://www.jimmunol.org/content/199/2/633

Simultaneous transmission of Borrelia burgdorferi and Babesia microti by individual nymphal Ixodes dammini ticks.. J Piesman, T ... Simultaneous transmission of Borrelia burgdorferi and Babesia microti by individual nymphal Ixodes dammini ticks. ... Simultaneous transmission of Borrelia burgdorferi and Babesia microti by individual nymphal Ixodes dammini ticks. ... Simultaneous transmission of Borrelia burgdorferi and Babesia microti by individual nymphal Ixodes dammini ticks. ...

https://jcm.asm.org/content/25/10/2012/article-info

Abstract The traditional therapy for the treatment of human Babesia microti infections has been the combination of clindamycin ... Atovaquone in the Treatment of Babesia microti Infections in Hamsters * Murray Wittner, Jeffrey Lederman, Herbert B. Tanowitz, ... The traditional therapy for the treatment of human Babesia microti infections has been the combination of clindamycin and ...

http://www.ajtmh.org/content/journals/10.4269/ajtmh.1996.55.219

... microti infections were followed for 270 days with regular thick blood smears. Three of the monkeys experienced from 1-3 ... Abstract To learn more about the course of Babesia microti infections in primates, six Macaca mulatta monkeys with blood- ... Experimental Babesia Microti Infections in Macaca Mulatta: Recurrent Parasitemia before and after Splenectomy * * Authors: ... To learn more about the course of Babesia microti infections in primates, six Macaca mulatta monkeys with blood-induced B. ...

http://www.ajtmh.org/content/journals/10.4269/ajtmh.1981.30.304

Failure of Chloroquine in Human Babesiosis (Babesia microti): Case Report and Chemotherapeutic Trials in Hamsters LOUIS H. ... The failure of a 3-week course of chloroquine to eliminate an infection of Babesia microti acquired on Marthas Vineyard led to ... MILLER LH, NEVA FA, GILL F. Failure of Chloroquine in Human Babesiosis (Babesia microti): Case Report and Chemotherapeutic ... Babesiosis in Washington State: A New Species of Babesia? Annals of Internal Medicine; 119 (4): 284-290 ...

http://annals.org/aim/article-abstract/691777/failure-chloroquine-human-babesiosis-babesia-microti-case-report-chemotherapeutic-trials

Human babesiosis due to Babesia microti is the most common and is endemic in North America. We report a European patient with ... severe pancytopenia and reactive hemophagocytosis related to a Babesia microti infection. Babesia infection was acquired during ... especially North America for the most common agent Babesia microti. ... for the most common agent Babesia microti. Babesia microti infection cannot be ruled out in patients with intact spleen in ...

https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-13-99

Transfusion-transmitted Babesia spp.: bulls-eye on Babesia microti. Clin Microbiol Rev 24:14-28. doi:10.1128/CMR.00022-10. ... Babesia is a protozoan transmitted by ixodid ticks that infects erythrocytes in the host animal. The Babesia microti group is a ... Development of Babesia microti sporozoites in adult Ixodes dammini. Int J Parasitol 16:381-385. doi:10.1016/0020-7519(86)90118- ... Babesia microti: infectivity of parasites from ticks for hamsters and white-footed mice. Exp Parasitol 53:242-248. doi:10.1016/ ...

https://aem.asm.org/content/82/22/6624

Babesia microti and Babesia rodhaini, were sequenced. The mt genomes of B. microti (11.1-kb) and B. rodhaini (6.9-kb) possess ... microti and B. rodhaini, respectively. We found a novel linear monomeric mt genome structure of B. microti and B. rhodhaini ... Plasmodium has a concatenated linear mt genome of the smallest size (6-kb); Babesia and Theileria have a linear monomeric mt ... We are interested in the evolutionary origin of linear mt genomes of Babesia/Theileria, and have investigated mt genome ...

https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-622

Babesia,/em, ,em,microti,/em, antibodies in plasma samples, and the in whole blood samples. ... microti) in human plasma samples and B. microti DNA in human whole blood samples.. The Babesia microti Arrayed Fluorescent ... and the Babesia microti Nucleic Acid Test (NAT) can perceive B. microti DNA in whole samples. Notably, the tests are not ... The approval of the Imugen Babesia microti AFIA and NAT tests was granted to Oxford Immunotec, Inc. Both assays are in-house ...

http://www.mdmag.com/medical-news/fda-approves-duo-of-babesia

Babesia sp EU1. Babesia microti. BORRELIA-BURGDORFERI. LYME-DISEASE. BOVINE BABESIOSIS. SOUTHERN GERMANY. EUROPE. INFECTION. ... First molecular evidence of potentially zoonotic Babesia microti and Babesia sp EU1 in Ixodes ricinus ticks in Belgium Laetitia ... a We report the first molecular evidence of the presence of Babesia sp. EU1 and Babesia microti in Ixodes ricinus ticks in ... a First molecular evidence of potentially zoonotic Babesia microti and Babesia sp EU1 in Ixodes ricinus ticks in Belgium ...

https://lib.ugent.be/catalog/pug01:1983213

Babesia Microti Babesiosis Borrelia Burgdorferi Dispatch Humans Incidence Incidence Studies Ixodes Ixodes Scapularis Lyme ... Infection with Babesia microti has not been well-described in eastern Pennsylvania, USA, despite the vector of this organism ... Human babesiosis is an emerging tick-borne disease caused by the intraerythrocytic protozoan Babesia microti. Its geographic ... Human Babesia microti Incidence and Ixodes scapularis Distribution, Rhode Island, 1998-2004 ...

https://stacks.cdc.gov/view/cdc/16507

"A Cluster of Cases of Babesia microti Among Neonates Traced to a Single Unit of Donor Blood, Pediatric Infectious Disease ... A Cluster of Cases of Babesia microti Among Neonates Traced to a Single Unit of Donor Blood. A Cluster of Cases of Babesia ... Seroprevalence of Babesia microti in blood donors from Babesia-endemic areas of the northeastern United States: 2000 through ... A Cluster of Cases of Babesia microti Among Neonates Traced to a Single Unit of Donor Blood. Glanternik, Julia R.; Baine, Ian L ...

https://www.deepdyve.com/lp/wolters_kluwer/a-cluster-of-cases-of-babesia-microti-among-neonates-traced-to-a-Okjiqpg0tN

Coincidence of three pathogens (Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti) in Ixodes ... Anaplasma phagocytophilum and Babesia microti in Ixodes ricinus ticks in south-eastern Poland and to estimate the degree of ... The PCR method was used to identify DNA for B. burgdorferi and A. phagocytophilum, and the nested-PCR - for B. microti. In ... microti, which equals 0.12% of the total number, were found. Infection with all 3 pathogens was identified in only 1 female ...

http://www.aaem.pl/Coincidence-of-three-pathogens-Borrelia-burgdorferi-sensu-lato-Anaplasma-phagocytophilum-and-Babesia-microti-in-Ixodes-ricinus-ticks-in-the-Lublin-macroregion-,71603,0,2.html

... microti thioredoxins may help to develop anti-Babesia drugs and controlling babesiosis. The full-length B. microti thioredoxin ... The predominant causative pathogen of this disease is the intra-erythrocytic parasite Babesia microti. The thioredoxin system ... Immunofluorescence microscopy showed that BmTrx2 localized in the cell cytoplasm of B. microti merozoites in B. microti- ... However, to date, the sequences and biological properties of thioredoxins and thioredoxin-like molecules of B. microti remain ...

https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-2619-9

In each of the tissue samples (blood or spleen), the prevalences of Babesia microti and Bartonella spp. were recorded as ... Co-occurrence of Babesia microti, Bartonella spp., Borrelia burgdorferi s.l. and Anaplasma phagocytophilum in rodents from ... Babesia microti, Borrelia burgdorferi s.l., Bartonella spp. and Anaplasma phagocytophilum, both blood and spleen samples were ... In examined rodent populations the prevalence of B. microti was 40.0%, Bartonella spp. 37.7%, B. burgdorferi s.l. 28.2% and A. ...

https://parasitesandvectors.biomedcentral.com/articles/10.1186/1756-3305-7-S1-O4

Babesia Microti Borrelia Burgdorferi Dispatch Female Ixodes Ixodes Scapularis Lyme Disease Polymerase Chain Reaction Time ... An investigation to determine if Babesia microti was present in local Ixodes scapularis ticks yielded 5 positive pools in 123 ... Anaplasma phagocytophilum, Babesia microti, and Borrelia burgdorferi in Ixodes scapularis, Southern Coastal Maine ... and Babesia microti, respectively. In 1996 and 1997, the number of A. phagocytophilum-infected ticks markedly declined. In 1995 ...

https://stacks.cdc.gov/view/cdc/14438

... the opposite is true of Babesia microti and babesiosis. Apart from parasitologists, Babesia is virtually unknown. Although ... B. microti is a piroplasm, a protozoal parasite, that bears some similarity to malaria, causing hemolytic disease which results ... 2. Centers for Disease Control, Parasites - Babesia. http://www.cdc.gov/parasites/babesiosis/ ...

http://fleshandbones1.blogspot.tw/2013/05/babesia-microti.html

Entry Terms : "Babesia microti Reagents, Identification" , "Babesia Species Reagents, Identification" , "Babesia microti ... Babesia microti, IgG Antibody. Definition : Serology reagents used to detect immunoglobulin G (IgG) antibodies to Babesia ... Home > Specialties > IVD Test Reagent/Kits, Serology, Parasite, Babesia microti, IgG Antibody ... " , "Babesia Species Detection/Identification Reagents" , "Reagents, Serology, Parasite, Babesia microti, IgG Antibody" ...

http://productguide.optometricmanagement.com/term/7162/reagents-serology-parasite-babesia-microti-igg-antibody

From Pardis Sabeti: "We have a new study on genetic diversity of Babesia microti, a tick-borne parasite causing the emerging ... We investigated the evolution, geographic expansion, and drug resistance of B. microti. ...

http://bobcowart.blogspot.com/2016/06/genetic-diversity-of-babesia-microti.html

Babesia microti. Although a few reports have described evidence of Babesia species in animals in Florida, to date Babesia ... Transfusion-transmitted Babesia spp.: bulls-eye on Babesia microti.. Leiby DA.. Source. Transmissible Diseases Department, ... Serologic studies that test for B microti do not detect infections due to these other strains of Babesia.. Babesia species in ... Current reviews of human babesiosis have called attention to strains of Babesia. which differ from the microti strain.. Babesia ...

https://www.lymeneteurope.org/forum/viewtopic.php?p=29672

Diagnosis of babesiosis: Evaluation of a serologic test for the detection of babesia microti antibody. Journal of Infectious ... Diagnosis of babesiosis : Evaluation of a serologic test for the detection of babesia microti antibody. In: Journal of ... Diagnosis of babesiosis : Evaluation of a serologic test for the detection of babesia microti antibody. / Krause, Peter J.; ... title = "Diagnosis of babesiosis: Evaluation of a serologic test for the detection of babesia microti antibody", ...

https://ucdavis.pure.elsevier.com/en/publications/diagnosis-of-babesiosis-evaluation-of-a-serologic-test-for-the-de-2

The protozoan parasites, Babesia microti and Babesia divergens are the major causes of human babesiosis in the United States and Europe, respectively. (frontiersin.org)
Survey of rodents and ticks in human babesiosis emergence area in Japan: first detection of Babesia microti-like parasites in Ixodes ovatus. (canarydatabase.org)
Babesiosis is a tick-borne zoonosis caused by protozoans of the genus Babesia , apicomplexan parasites that replicate within erythrocytes. (jimmunol.org)
Current blood bank screening methods do not identify infected donors, and Babesia parasites survive blood-banking procedures and storage. (jimmunol.org)
Babesia are piroplasms, small pear-shaped protozoan parasites that belong to the phylum Apicomplexa, which includes the other human pathogens Plasmodium , Toxoplasma , and Cryptosporidium . (jimmunol.org)
The Babesia microti group is a diverse group of worldwide-distributed parasites that includes various lineages, such as U.S., Kobe, Hobetsu, Munich, monkey/squirrel, and some still-unnamed groups ( 1 - 5 ). (asm.org)
The complete mt genomes of archaeopiroplasmid parasites, Babesia microti and Babesia rodhaini , were sequenced. (biomedcentral.com)
Babesia parasites cause babesiosis, which commonly is asymptomatic in most individuals, and can be destructive for those individuals with severe infection. (mdmag.com)
2. Centers for Disease Control, Parasites - Babesia . (blogspot.tw)
Human babesiosis is an emerging tick-borne zoonotic disease caused by the protozoan parasites of the genus Babesia. (lymeneteurope.org)
Babesiosis is a condition, where the red blood cells of vertebrates are infected with microscopic parasites belonging to the genus, Babesia . (medindia.net)
Human babesiosis is a zoonotic disease caused by protozoan parasites of the Babesia genus, primarily in the Northeastern and Midwest USA due to Babesia microti and Western Europe due to Babesia divergens . (springer.com)
Human babesiosis is a zoonotic infection caused by Babesia parasites transmitted by the bite of ixodid ticks that have distinct geographical distributions based on the presence of their competent natural animal hosts, which include rodents, cattle, and deer. (springer.com)
Babesia parasites are intracellular obligates that target red blood cells, and the parasite's ability to first recognize and then invade host RBCs is central to the disease pathology. (springer.com)
The only confirmed vectors of Babesia parasites are members of the Ixodidae family. (springer.com)
Humans may be subjected to the parasites through cattle ( Babesia bovis ) or rodents ( Babesia microti ), but only a few cases are reported each year, usually among the elderly or those with compromised immune systems. (kenyon.edu)
Life cycle of Babesia Image from Gardiner CH, Fayer R, Dubey JP: An Atlas of Protozoan Parasites in Animal Tissues. (kenyon.edu)
Babesia is a group of parasites which are transmitted from host to host through an intermediate tick host. (kenyon.edu)
Blood samples are sent to specialized labs that search for signs and indicators that suggest babesia parasites are present. (medicalnewstoday.com)
In some people, babesia parasites may go undetected, which can lead to the parasites being spread through blood transfusions. (medicalnewstoday.com)
Babesiosis is a worldwide tick-borne hemolytic disease that is caused by intraerythrocytic protozoan parasites of the genus Babesia. (aafp.org)
Babesia are intraerythrocytic parasites of importance worldwide within the fields of human and veterinary medicine, as some Babesia sp. (cambridge.org)
Transfusion-acquired, autochthonous human babesiosis in Japan: isolation of Babesia microti-like parasites with hu-RBC-SCID mice. (springer.com)

The majority of babesia infections in Europe are life-threatening and caused by Babesia divergens and B. bovis. (nih.gov)
Cross-reactivity may occur with other human pathogenic species, such as Babesia duncani (WA-1), Babesia divergens , and Babesia MO-1. (labcorp.com)
Of the more than 70 species worldwide in the genus Babesia, human infections are largely due to the rodent strain B microti (found only in the United States) and the cattle strains Babesia divergens and Babesia bovis (found only in Europe). (lymeneteurope.org)
B microti measures 2 X 1.5 mm, B divergens measures 4 X 1.5 mm, and B bovis measures 2.4 X 1.5 mm. (lymeneteurope.org)
In Europe, the bovine parasite Babesia divergens causes a severe form of human babesiosis. (medindia.net)
B. microti) and Europe (B. divergens & B. venatorum). (ekb.eg)
As sampling has become expansive and techniques have become more sensitive, there is evidence that more B. microti -like and B. divergens -like spp. (springer.com)
Babesia divergens and Babesia microti ). (biologists.org)
Of the more than 100 species of Babesia, Babesia microti (in the United States) and Babesia divergens and Babesia bovis (in Europe) cause most infections in humans. (aafp.org)
B. microti also infects various small mammals and primates, while B. divergens has been found to infect rats and gerbils as well as its main bovine host. (aafp.org)

This test is intended to be used as an aid in the diagnosis of Babesia microti infection. (labcorp.com)
Infection of C3H/HeJ mice with B. burgdorferi and B. microti individually results in inflammatory Lyme disease and display of human babesiosis-like symptoms, respectively. (frontiersin.org)
We show that B. burgdorferi infection attenuates parasitemia in mice while B. microti subverts the splenic immune response, such that a marked decrease in splenic B and T cells, reduction in antibody levels and diminished functional humoral immunity, as determined by spirochete opsonophagocytosis, are observed in co-infected mice compared to only B. burgdorferi infected mice. (frontiersin.org)
This study demonstrates the effect of only simultaneous infection by B. burgdorferi and B. microti on each pathogen, immune response and on disease manifestations with respect to infection by the spirochete and the parasite. (frontiersin.org)
Infection with Babesia microti has not been well-described in eastern Pennsylvania, USA, despite the vector of this organism being prevalent. (cdc.gov)
However, unlike related Plasmodium species, the pathogenesis of Babesia infection remains poorly understood. (jimmunol.org)
In healthy individuals, tick-transmitted infection with Babesia causes no specific clinical manifestations, with many having no symptoms at all. (jimmunol.org)
Thus, Babesia can also be transmitted by infected blood, and it is currently the number one cause of reportable transfusion-transmitted infection in the United States. (jimmunol.org)
We found that B. microti reaches high parasitemia levels during the first week of infection in all three mice strains before resolving spontaneously. (jimmunol.org)
Babesia is a threat to the blood supply and is now the most common transfusion-transmitted infection in the United States that is reported to the U.S. Food and Drug Administration ( 1 , 2 ). (jimmunol.org)
These findings suggest that similar recurrences of parasitemia may occur in human cases, and that splenectomy may present a risk to persons with a past history of B. microti infection. (ajtmh.org)
The failure of a 3-week course of chloroquine to eliminate an infection of Babesia microti acquired on Martha's Vineyard led to tests of selected drugs in hamsters infected with the strain from this patient. (annals.org)
We report a European patient with severe pancytopenia and reactive hemophagocytosis related to a Babesia microti infection. (biomedcentral.com)
Babesia infection was acquired during a travel in the USA. (biomedcentral.com)
Data collected from testing and additional studies performed by the manufacturer reportedly prevented the release of hundreds of possibly infectious donations, according to the FDA, and validated the tests as efficacious in screening donors for B. microti infection. (mdmag.com)
This study has demonstrated a low infection rate (1.31% with 95% CI: 0.65-2.33) of Babesia spp. (ugent.be)
The aim of the study was to determine the coincidence of 3 pathogens: Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in Ixodes ricinus ticks in south-eastern Poland and to estimate the degree of infection with each of the examined pathogens depending on the developmental stage of ticks (nymph, female, male). (aaem.pl)
The most common symptoms of severe infection Babesia are hemolytic anaemia and jaundice. (biomedcentral.com)
Skrabalo was the first to identify a human infection caused by Babesia in 1957 in the former Yugoslavia. (lymeneteurope.org)
In 1969, infection with Babesia microti was described in a patient with an intact spleen from Nantucket Island off the coast of Massachusetts. (lymeneteurope.org)
She was identified with babesiosis allegedly resulting from an infection with Babesia microti ( B. microti ) after receiving a contaminated blood transfusion. (hindawi.com)
Also disclosed is an IgG and IgM ELISA using two novel recombinant antigens in the diagnosis of Babesia infection. (patentsencyclopedia.com)
The host for Babesia microti is the white footed mouse, Peromyscus leucopus, although other small rodents are also susceptible to infection (Horner et al. (patentsencyclopedia.com)
[0004] Babesia microti infection causes a malaria-like disease including malaise, chills, anemia, fatigue, fever and myalgia. (patentsencyclopedia.com)
Proper diagnosis of Babesia infection is necessary for the treatment of the disease. (patentsencyclopedia.com)
Babesiosis is an emerging infection in the United States, principally caused by Babesia microti ( 1 ). (cdc.gov)
We determined the prevalence of polymicrobial infection with Borrelia burgdorferi, Anaplasma phagocytophilum, Babesia microti, Borrelia miyamotoi, and Powassan virus in 286 adult ticks from the two counties in New York State where Lyme disease is endemic, utilizing a MassTag multiplex polymerase chain reaction assay. (nih.gov)
In this study, the prevalence of T. gondii and B. microti infection in blood samples of 5 animal species (37 Chinese water deer, 23 raccoon dogs, 6 roe deer, 1 wild boar, and 3 Eurasian badgers) was examined during 2008-2009 in Gangwon-do (Province), the Republic of Korea (=Korea) by using serological and molecular tests. (bvsalud.org)
PCR revealed only 1 case of T. gondii infection in Chinese water deer, and phylogenic analysis showed that the positive isolate was practically identical to the highly pathogenetic strain type I. In B. microti PCR, the positive rate was 5.7% (4/70), including 2 Chinese water deer and 2 Eurasian badgers. (bvsalud.org)
In this study, we aimed to investigate Babesia microti infection frequency in a human population in Mongolia. (bvsalud.org)
The sera and DNA from blood samples were evaluated for the presence of B. microti infection by using indirect fluorescent antibody (IFA) tests and PCR. (bvsalud.org)
Small mammals and ticks were examined for Babesia infection. (annals.org)
Babesia serological testing is used to diagnose infection by the Babesia tick-borne protozoan. (questdiagnostics.com)
The primary objectives of our research program are to identify new targets for development of potent and selective new therapies to treat these diseases and to develop a new diagnostic test for early detection of Babesia infection to prevent transfusion transmitted babesiosis. (yale.edu)
Babesia microti is the pathogen responsible for babesiosis, a tick-associated infection that occurs in the coastal northeastern and upper midwestern United States. (acpinternist.org)
However, little is known about the accuracy of these procedures or the prevalence of infection with or without the presence of other tick-borne pathogens, such as Ehrlichia chaffeensis , Borrelia burgdorferi , and Babesia microti . (asm.org)

In this study, the prevalence of antibodies against two Babesia spp. (medworm.com)
However, the specific tick vector(s) remains unidentified in Eurasia, where there are people with antibodies to the B. microti U.S. lineage and cases of human babesiosis. (asm.org)
The US Food and Drug Administration (FDA) has granted approval of 2 tests from Imugen with the ability to detect antibodies to Babesia microti ( B. microti ) in human plasma samples and B. microti DNA in human whole blood samples. (mdmag.com)
The Babesia microti Arrayed Fluorescent Immunoassay (AFIA) can distinguish antibodies in plasma samples, and the Babesia microti Nucleic Acid Test (NAT) can perceive B. microti DNA in whole samples. (mdmag.com)
Serology reagents used to detect immunoglobulin G (IgG) antibodies to Babesia microti, a hematozoan protozoon. (optometricmanagement.com)
antibodies in the heel-stick blood sample and confirmed by detection of Babesia spp. (lymeneteurope.org)
All sera samples were assessed for IgG antibodies against Babesia (Ba. (nih.gov)
antibodies in a heel spot blood sample and confirmed by detection of Babesia DNA in placenta tissue. (cdc.gov)

Babesia microti is a parasitic blood-borne piroplasm transmitted by deer ticks. (wikipedia.org)
B. microti is transmitted to humans primarily through the bite of Ixodes scapularis ticks, which are vectors for a number of other pathogens. (mdpi.com)
Although Babesia microti has been detected in ticks from Switzerland, few if any cases of babesiosis have been caused by B. microti. (nih.gov)
Simultaneous transmission of Borrelia burgdorferi and Babesia microti by individual nymphal Ixodes dammini ticks. (asm.org)
Molecular detection and characterisation of Babesia and Theileria in Australian hard ticks. (annals.org)
In this study, the first isolation of B. microti U.S. lineage from Ixodes persulcatus ticks, a principal vector for many tick-borne diseases, is described in Japan. (asm.org)
Babesia is a protozoan transmitted by ixodid ticks that infects erythrocytes in the host animal. (asm.org)
EU1 and Babesia microti in Ixodes ricinus ticks in Belgium. (ugent.be)
Coincidence of three pathogens (Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti) in Ixodes ricinus ticks in the Lublin macroregion. (aaem.pl)
The assay was able to simultaneously detect and differentiate Anaplasma phagocytophilum, Borrelia burgdorferi, Borrelia miyamotoi, Babesia microti, and the Powassan virus in I. scapularis (black-legged) ticks. (danielcameronmd.com)
Our finding of a high frequency of ticks infected with Babesia microti in Suffolk County, NY, implicates this agent as a probable frequent cause of non-Lyme tick-borne disease in this area," explains Tokarz and colleagues. (danielcameronmd.com)
Detection of Anaplasma phagocytophilum, Babesia microti, Borrelia burgdorferi, Borrelia miyamotoi, and Powassan Virus in Ticks by a Multiplex Real-Time Reverse Transcription-PCR Assay. (danielcameronmd.com)
In North America, the deer ticks Ixodes scapularis transmit Babesia microti to human hosts. (medindia.net)
Theileria microti is a parasitic blood-borne piroplasm transmitted by deer ticks. (wikipedia.org)
Detection of novel piroplasmid species and Babesia microti and Theileria orientalis genotypes in hard ticks from Tengchong County, Southwest China. (madisonarealymesupportgroup.com)
To reveal the genetic diversity of Babesia microti and Theileria orientalis in Southwest China, we conducted a molecular survey of piroplasms in hard ticks in a China-Myanmar border county. (madisonarealymesupportgroup.com)
All members of Babesia exhibit two life cycles: one in the invertebrate host (almost always ticks) and one in the vertebrate host. (kenyon.edu)
In addition to carrying Lyme disease, some ticks also carry a microparasite known as Babesia microti that can infect human blood. (medicalnewstoday.com)
Babesia microti is a malaria-like parasite that lives in certain kinds of ticks. (medicalnewstoday.com)
Ticks, the first host, transmit babesia to humans via a bite. (medicalnewstoday.com)
Ticks ingest Babesia while feeding off the host, and the parasite multiplies within the tick's gut wall. (aafp.org)
Detection and molecular characterization of Babesia, Theileria, and Hepatozoon species in hard ticks collected from Kagoshima, the southern region in Japan. (pubfacts.com)

Until 2006 B. microti was thought to belong to the genus Babesia, as Babesia microti, until ribosomal RNA comparisons placed it in the sister genus Theileria. (wikipedia.org)
It shows that the species does not belong to either of the established genera - Babesia and Theileria - but instead belongs to a separate genus. (wikipedia.org)
Babesia is a genus of parasitic protozoans which affect several vertebrates, including (though rarely) humans. (kenyon.edu)

Ixodes ricinus as a vector of Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in urban and suburban forests. (canarydatabase.org)
B. microti is transmitted by the Ixodes scapularis tick, which is also the vector of Borrelia burgdorferi and Anaplasma phagocytophilum ( 2 ). (cdc.gov)
2] In the northeastern United States, the black-legged deer tick Ixodes scapularis, also called Ixodes dammini (see the image below), is the principal vector for transmitting the etiologic agent B microti. (lymeneteurope.org)
In China, the vector is Ixodes persulcatus for transmitting Babesia venatorum . (medindia.net)

To assess the possibility of standardization of a commonly used indirect immunofluorescent antibody (IFA) test for detection of Babesia microti antibody in human sera, the results from four reference laboratories were compared. (elsevier.com)
Anti-Babesia antibody titers were determined in a blinded fashion by IFA test. (elsevier.com)
This B. microti IFA procedure is a sensitive, specific, and reproducible method for diagnosing babesiosis and is suitable for use as a standard in laboratories testing human sera for B. microti antibody. (elsevier.com)
8. The article of manufacture of claim 7, wherein said packaging material comprises an instruction for detecting the presence of an antibody against Babesia microti. (patentsencyclopedia.com)
This study is the first to detect of B. microti infections based on antibody seroprevalence or PCR assays for the presence of B. microti DNA in a Mongolian population. (bvsalud.org)
The TBD-Serochip was designed to discriminate antibody responses to 8 major tick-borne pathogens present in the United States, including Anaplasma phagocytophilum, Babesia microti , Borrelia burgdorferi , Borrelia miyamotoi , Ehrlichia chaffeensis , Rickettsia rickettsii , Heartland virus and Powassan virus. (nature.com)
Serum specimens from the patient were assayed by indirect immunofluorescent antibody (IFA) testing for reactivity with seven Babesia species and with WA1, which was propagated in hamsters inoculated with his blood. (annals.org)
Popovsky MA, Lindberg LE, Syrek AL, Page PL. Prevalence of Babesia antibody in a selected blood donor population. (springer.com)

Today's actions represent the first approvals of Babesia detection tests for use in screening donors of whole blood and blood components, and other living donors. (mdmag.com)
We have developed 2 real-time multiplex PCR assays for detection of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti. (cdc.gov)
Infections of Toxoplasma gondii and Babesia microti are reported in many wild animals worldwide, but information on their incidence and molecular detection in Korean wild fields is limited. (bvsalud.org)

Co-occurrence of Babesia microti, Bartonella spp. (biomedcentral.com)
In examined rodent populations the prevalence of B. microti was 40.0%, Bartonella spp. (biomedcentral.com)
In each of the tissue samples (blood or spleen), the prevalences of Babesia microti and Bartonella spp. (biomedcentral.com)
The worst ones are Babesia microti and the different forms of Bartonella . (care2.com)

Because of the need for a vaccine, the genome sequence of Babesia bovis is currently being mapped. (kenyon.edu)
Most Babesia species are host-specific, so Babesia bovis is found on cattle farms and ranches, Babesia canis is prevalent in kennels and dog-breeding facilities, etc. (kenyon.edu)

The predominant causative pathogen of this disease is the intra-erythrocytic parasite Babesia microti . (biomedcentral.com)
Phylogenetically, WA-1 strain Babesia is closely related to Babesia gibsoni, a canine pathogen. (lymeneteurope.org)

Co-infections with the tick-transmitted pathogens Babesia microti and Borrelia burgdorferi sensu stricto are becoming a serious health problem. (frontiersin.org)
The traditional therapy for the treatment of human Babesia microti infections has been the combination of clindamycin and quinine. (ajtmh.org)
To learn more about the course of Babesia microti infections in primates, six Macaca mulatta monkeys with blood-induced B. microti infections were followed for 270 days with regular thick blood smears. (ajtmh.org)
The actual incidence of Babesia infections, however, has remained elusive. (nih.gov)
Our findings suggest that Babesia infections may indeed be quite common among individuals who have been exposed to tick bites. (nih.gov)
exists worldwide and Babesia microti is the most common cause of babesial infections in the United States. (patentsencyclopedia.com)
IFA is recommended for diagnosis of tick-borne infections with Babesia , Anaplasma , Ehrlichia and Rickettsia . (nature.com)
Babesia microti (in the United States) and bovine strains (in Europe) cause most infections in humans. (aafp.org)
Between 1968 and 1993, more than 450 Babesia infections were confirmed in the United States by blood smears or serologic testing, but the prevalence of babesiosis is difficult to estimate because of lack of surveillance, and because infections are often asymptomatic. (aafp.org)

This review discusses the current literature on mammalian coinfection with B. microti and Borrelia burgdorferi , the causative agent Lyme disease. (mdpi.com)
microti and Borrelia burgdorferi sensu stricto also was demonstrated. (ugent.be)
For the analysis of co-occurrence of pathogens, Babesia microti, Borrelia burgdorferi s.l. (biomedcentral.com)
If symptoms persist but Babesia organisms are no longer detected, one should consider the possibility of addition concurrent Lyme disease (caused by the spirochete Borrelia burgdorferi sensu stricto in the USA) and/or concurrent human granulocytic anaplasmosis (caused by the obligate intracellular bacterium Anaplasma phagocytophilum ). (renalandurologynews.com)
Also included were other tests for Ehrlichia chaffeensis , the agent of human monocytic ehrlichiosis (HME), Babesia microti , and Borrelia burgdorferi . (asm.org)

B. burgdorferi is an extracellular spirochete that causes Lyme disease while B. microti is a protozoan that infects erythrocytes and causes babesiosis. (frontiersin.org)
Furthermore, immunosuppression by B. microti in co-infected mice showed an association with enhanced Lyme disease manifestations. (frontiersin.org)
While nearly everyone has heard of Lyme disease, and its notoriety has been enhanced by media and pop culture, the opposite is true of Babesia microti and babesiosis . (blogspot.tw)
Although the signs and symptoms of Lyme disease differ from those of babesiosis, the tick vector associated with Lyme disease ( I scapularis ) may also transmit Babesia organisms. (medscape.com)
Babesia and Lyme disease: What's the connection? (medicalnewstoday.com)
Babesia and Lyme disease are considered coinfections. (medicalnewstoday.com)
However, babesia and Lyme disease are not dependent on each other to exist. (medicalnewstoday.com)
Fortunately, babesia and Lyme disease exist together in a very small percentage of cases. (medicalnewstoday.com)

Indirect immunofluorescence assay was used to localize BmTrx2 in B. microti . (biomedcentral.com)
We analyzed the performance of our HRM assay using 26 B. microti clinical samples used in our WGS study from babesiosis endemic regions in the United States. (cdc.gov)
To enable surveillance for all major I. scapularis -borne pathogens, we developed a multiplex one-step real-time reverse transcription-PCR (RT-PCR) assay that targets A. phagocytophilum, B. microti, B. miyamotoi, B. burgdorferi, and POWV," explains Tokarz. (danielcameronmd.com)
In this study, we describe a real-time multiplex PCR assay to detect the presence of B. burgdorferi, B. microti and A. phagocytophilum simultaneously even when they are present in very low copy numbers. (beds.ac.uk)

From Pardis Sabeti: "We have a new study on genetic diversity of Babesia microti, a tick-borne parasite causing the emerging human disease babesiosis, an illness with symptoms similar to malaria found in the Northeast and Midwest United States. (blogspot.com)

As of 2012[update], the medical community still classified the parasite as Babesia microti though its genome showed it does not belong to either Babesia or Theileria. (wikipedia.org)
We are interested in the evolutionary origin of linear mt genomes of Babesia / Theileria , and have investigated mt genome structures in members of archaeopiroplasmid, a lineage branched off earlier from Babesia / Theileria . (biomedcentral.com)
In the phylum Apicomplexa, which includes important pathogens such as the causative agents of malaria ( Plasmodium ), coccidiosis ( Eimeria ), and piroplasmosis ( Babesia and Theileria ), the mt genome structure is also diverse. (biomedcentral.com)
The gene arrangements and transcriptional direction are however different from Babesia / Theileria . (biomedcentral.com)
The genome of Theileria microti (aka Babesia microti) has been sequenced and published 2012. (wikipedia.org)
Reclassification of Theileria annae as Babesia vulpes sp. (cambridge.org)

Babesia are intracellular pathogens that replicate exclusively in the cytosol of erythrocytes ( 5 ). (jimmunol.org)
In addition, coinfection with tick-borne pathogens, Babesia species and Anaplasma phagocytophilum has been increasing in endemic regions of the USA and Europe. (beds.ac.uk)

In North America, Babesia microti is the primary etiologic agent for most cases of babesiosis, with B. duncani responsible for cases of babesiosis in the Pacific northwest ( 1 , 3 , 4 ). (jimmunol.org)
Sporadic cases of babesiosis due to Babesia duncani (isolates WA-1 and CA-5) have been reported in Washington and northern California. (lymeneteurope.org)

The results of Western blot analysis showed the native BmTrx2 in parasite lysates could be detected by mouse anti-BmTrx2 serum and that the recombinant BmTrx2 protein could be recognized by serum of B. microti -infected mice. (biomedcentral.com)
Serum specimens from 83 family members and neighbors were assayed for IFA reactivity with WA1 and B. microti . (annals.org)
The patient's serum had very strong IFA reactivity with WA1, strong reactivity with B. gibsoni (which infects dogs), but only weak reactivity with B. microti . (annals.org)

1 tick was positive for 3 agents ( B. burgdorferi, B. microti, and B. miyamotoi ). (danielcameronmd.com)

including Babesia microti are potentially zoonotic and can cause fatal disease in both humans and animals. (cambridge.org)

Babesia microti is tick-borne disease that is an emerging threat to public health due to increasing prevalence and expanding geographic range. (cdc.gov)
The real surprise was the high prevalence of B. microti , the causative agent of babesiosis. (danielcameronmd.com)
These results indicate a potentially high prevalence of T. gondii and B. microti in wild animals of Gangwon-do, Korea. (bvsalud.org)

Finally, under the microscope, the merozoite form of the B. microti lifecycle in red blood cells forms a cross-shaped structure, often referred to as a "Maltese cross" or tetrad, in addition to intracellular "ring forms" which are also seen in the malaria parasite (Plasmodium spp. (wikipedia.org)
Our laboratory has discovered new pathways that play a critical function in Plasmodium falciparum and Babesia microti development and differentiation. (yale.edu)

Thus, current serological tests based on U.S. isolates may underestimate B. microti occurrence outside the United States. (asm.org)
Phylogenetic analysis results of 18S rRNA and the β-tubulin gene showed that all positive isolates were US-type B. microti. (bvsalud.org)
Phylogenetic analysis showed that the three isolates are closely related to Babesia annae, B. microti and other Piroplasmida species found in wildlife. (cambridge.org)

B. microti is responsible for the disease babesiosis, a malaria-like disease which also causes fever and hemolysis. (wikipedia.org)
An important difference from malaria is that B. microti does not infect liver cells. (wikipedia.org)
B. microti is a piroplasm, a protozoal parasite, that bears some similarity to malaria, causing hemolytic disease which results in generalized "flu-like" symptoms that are often difficult to accurately diagnose. (blogspot.tw)
T. microti is responsible for the disease human theileriosis, similar to babesiosis, a malaria-like disease which also causes fever and hemolysis. (wikipedia.org)
Finally, under the microscope, the merozoite form of the T. microti lifecycle in red blood cells forms a cross-shaped structure, often referred to as a "Maltese cross", whereas malaria forms more of a diamond ring structure in red blood cells. (wikipedia.org)
Other available projects include the development of a humanized mouse model for falciparum and vivax malaria, and development of new tools for genetic manipulation of B. microti. (yale.edu)

This test is intended to detect Babesia microti , the primary etiologic agent of human babesiosis in the United States. (labcorp.com)

Multiplex real-time PCR assays can typically identify B. burgdorferi, B. microti , and A. phagocytophilum . (danielcameronmd.com)

Human babesiosis due to Babesia microti is the most common and is endemic in North America. (biomedcentral.com)
Babesiosis should be considered in patients who traveled in endemic areas, especially North America for the most common agent Babesia microti . (biomedcentral.com)
In North America, the rodent (mice with white feet) parasite Babesia microti or a second species, the WA1 piroplasm, cause babesiosis in humans. (medindia.net)

A polymerase chain reaction technique amplifying a part of the 18S rRNA gene detected Babesia spp. (ugent.be)
Symptomatic patients if Babesia is detected on blood smear or by polymerase chain reaction (PCR). (renalandurologynews.com)

The incidence of B. microti in Connecticut was lower but still noteworthy with 7% of nymphs and 14% of adults infected. (danielcameronmd.com)

Babesia species from rodents, primarily the white-footed deer mouse but also the field mouse, vole, rat, and chipmunk, are transmitted to humans during tick bites in endemic areas. (lymeneteurope.org)
A recent study in China, identified Babesia venatorum as the cause for babesiosis in humans. (medindia.net)
Babesia Microti is pathogenic in humans. (madisonarealymesupportgroup.com)
Humans are the second and end-stage host organism for babesia. (medicalnewstoday.com)

Tick inserts denticles into the flesh of the victim, opens them like an umbrella during blood meal, and infects the host with babesia (sporozoites). (hindawi.com)

a peripheral blood smear showed Babesia microti in 3% of his erythrocytes. (change.org)

This could be the first study in Qena that screened Egyptian patients using well-defined Babesia strain for human babesiosis. (ekb.eg)

Babesia, is an intraerythrocytic protozoan parasite (Figures 2 and 3 , blood from experimentally infected hamster with B. microti ) which can cause a spectrum of flu-like symptoms, including benign headache and fever, in immunocompetent patients. (hindawi.com)

B. burgdorferi, A. phagocytophilum and B. microti have overlapping epidemiology and transmission cycles with shared tick vectors, and common primary and secondary host reservoirs. (beds.ac.uk)

Although B. burgdorferi is endemic to Pennsylvania ( 3 ), B. microti is not considered endemic to this region ( 4 , 5 ). (cdc.gov)
The PCR method was used to identify DNA for B. burgdorferi and A. phagocytophilum, and the nested-PCR - for B. microti. (aaem.pl)
Only 2 cases of the coinfection of B. burgdorferi s. l. with B. microti, which equals 0.12% of the total number, were found. (aaem.pl)

On the right side an intra-erythrocytic ring of Babesia microt i can be observed in a red blood cell (arrow). (biomedcentral.com)
Blood smear stained with Giemsa (magnification x 100) showing intra-erythrocytic forms of Babesia microti . (biomedcentral.com)

The aims of this study were to use a nested PCR (amplifying the 18S rRNA gene) to determine the presence and species of Babesia parasite DNA found in blood ( n = 47) and spleen ( n = 47) samples collected from Eurasian badgers ( Meles meles ) in Scotland. (cambridge.org)

However, even in asymptomatic people, a Babesia carriage state can be established that can last up to a year or more. (jimmunol.org)
Our blood supply is at risk from asymptomatic Babesia carriers donating infected blood ( 8 - 10 ). (jimmunol.org)
Asymptomatic individuals if Babesia has been detected on blood smear or by PCR for longer than 3 months. (renalandurologynews.com)
Babesia has been detected on blood smear or by PCR for less than 3 months in an asymptomatic individual. (renalandurologynews.com)

IMPORTANCE The major cause of human babesiosis, the tick-borne blood parasite Babesia microti , U.S. lineage, is widely distributed in the temperate Northern Hemisphere. (asm.org)
Babesiosis is caused by the parasite babesia. (medicalnewstoday.com)

The U.S. lineage, one of the major clades in the Babesia microti group, is known as a causal agent of human babesiosis mostly in the northeastern and upper midwestern United States. (asm.org)

[0003] Babesia microti is an apicomplexan intraerythrocytic parasite that is the etiological agent of babesiosis. (patentsencyclopedia.com)

The life cycle of B. microti includes human red blood cells and is an important transfusion-transmitted infectious organism. (wikipedia.org)
In the United States, Babesia microti is the most common species that causes human babesiosis. (cdc.gov)
Despite a significant impact on human health, B. microti remains understudied. (jimmunol.org)
Yale U had developed a potential treatment for babesia, but it needs to advance to human trials. (danielcameronmd.com)

The approval of the Imugen Babesia microti AFIA and NAT tests was granted to Oxford Immunotec, Inc. Both assays are in-house tests that can only be performed at the Norwood, Massachusetts facility. (mdmag.com)

Approval Letter -Babesia microti AFIA/Babesia microti AFIA for Blood Donor Screening (PDF) (Report). (wikipedia.org)
Other routes of B. microti transmission are blood transfusion and in rare cases of mother-to-foetus transmission, through the placenta. (mdpi.com)
Testing of donated blood for Babesia species is not currently mandatory due to unavailability of an FDA approved test. (frontiersin.org)
Wright-stained blood smear for patient 1 with babeosis on day 1 of hospitalization, eastern Pennsylvania, USA, showing an intraerythrocytic trophozoite of Babesia microti in a ring form (thin arrow) and. (cdc.gov)
A PCR result for the blood sample was positive for B. microti . (cdc.gov)
Seroprevalence of Babesia microti in blood donors from Babesia-endemic areas of the northeastern United States: 2000 through 2007. (deepdyve.com)
Screening for Babesia microti in the U.S. Blood Supply. (deepdyve.com)
Immunofluorescence microscopy showed that BmTrx2 localized in the cell cytoplasm of B. microti merozoites in B. microti- infected red blood cells. (biomedcentral.com)
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the high oxygen environment of mammalian hosts' red blood cells (RBCs) are toxic to Babesia trophozoites and merozoites. (biomedcentral.com)
T. microti lives in red blood cells, and is an important transfusion-transmitted infectious organism. (wikipedia.org)
It is here that the merozoite form of Babesia wreaks the most havoc on the host, as it destroys red blood cells and causes anemia. (kenyon.edu)
Like all apicomplexans, Babesia' s cells invade the host's red blood cells by way of the apicoplast, an organelle unique to members of this phylum. (kenyon.edu)
Babesia is not detected on blood smear or by PCR. (renalandurologynews.com)
If symptoms relapse, Babesia organisms should be investigated by blood smear or PCR. (renalandurologynews.com)
As part of the diagnosis, a doctor will likely examine a blood smear under a microscope to look for signs of the babesia parasite. (medicalnewstoday.com)
The results showed 28/47 (59·6%) blood and 14/47 (29·8%) spleen samples tested positive for the presence of Babesia DNA. (cambridge.org)

The genome of Babesia microti has been sequenced and published. (wikipedia.org)
The mt genomes of B. microti (11.1-kb) and B. rodhaini (6.9-kb) possess two pairs of unique inverted repeats, IR-A and IR-B. Flip-flop inversions between two IR-As and between two IR-Bs appear to generate four distinct genome structures that are present at an equi-molar ratio. (biomedcentral.com)
An individual parasite contained multiple mt genome structures, with 20 copies and 2 - 3 copies per haploid nuclear genome in B. microti and B. rodhaini , respectively. (biomedcentral.com)
We found a novel linear monomeric mt genome structure of B. microti and B. rhodhaini equipped with dual flip-flop inversion system, by which four distinct genome structures are readily generated. (biomedcentral.com)
Leveraging our whole genome sequence (WGS) analyses of B. microti, we developed a single nucleotide polymorphism (SNP)-based high resolution melt (HRM) surveillance tool. (cdc.gov)

Quantitative Babesia microti Genomic DNA is total DNA isolated from hamsters infected with the organism Babesia microti . (atcc.org)

We report the first molecular evidence of the presence of Babesia sp. (ugent.be)
Understanding the molecular characterization and function of B. microti thioredoxins may help to develop anti- Babesia drugs and controlling babesiosis. (biomedcentral.com)
Improved serodiagnostic and molecular techniques are needed for characterizing Babesia species and elucidating the epidemiology of babesiosis, an emergent zoonosis. (annals.org)

Seropositive IgG titers for at least one of the Babesia spp. (nih.gov)
Using IFA 13/43 patients were positive for Babesia at different titers. (ekb.eg)

Together with previous epidemiological and transmission studies, we conclude that I. persulcatus is likely the principal vector for the B. microti U.S. lineage in Japan and presumably in northeastern Eurasia. (asm.org)
Babesia tick vector. (kenyon.edu)

Tengchong, China, closely related to Babesia species isolated from yak and Piroplasmid sp. (madisonarealymesupportgroup.com)

1 - 3 Intraerythrocytic piroplasms consistent with Babesia were first described by Babès in 1888 in his evaluation of the cause of febrile hemoglobinuria in cattle in Romania. (aafp.org)

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Roles of the Maltese cross form in the development of parasitemia and protection against Babesia microti infection in mice. (1/65)

The prevalence of piroplasms in a population of Ixodes ricinus (Acari: Ixodidae) from north-western Poland. (2/65)

Transfusion-associated babesiosis after heart transplant. (3/65)

Identification and characterization of putative secreted antigens from Babesia microti. (4/65)

Increasing health burden of human babesiosis in endemic sites. (5/65)

Age-associated decline in resistance to Babesia microti is genetically determined. (6/65)

Survey of rodents and ticks in human babesiosis emergence area in Japan: first detection of Babesia microti-like parasites in Ixodes ovatus. (7/65)

Prevalence of Borrelia burgdorferi, Bartonella spp., Babesia microti, and Anaplasma phagocytophila in Ixodes scapularis ticks collected in Northern New Jersey. (8/65)

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Roles of the Maltese cross form in the development of parasitemia and protection against Babesia microti infection in mice. (1/65)

The prevalence of piroplasms in a population of Ixodes ricinus (Acari: Ixodidae) from north-western Poland. (2/65)

Transfusion-associated babesiosis after heart transplant. (3/65)

Identification and characterization of putative secreted antigens from Babesia microti. (4/65)

Increasing health burden of human babesiosis in endemic sites. (5/65)

Age-associated decline in resistance to Babesia microti is genetically determined. (6/65)

Survey of rodents and ticks in human babesiosis emergence area in Japan: first detection of Babesia microti-like parasites in Ixodes ovatus. (7/65)

Prevalence of Borrelia burgdorferi, Bartonella spp., Babesia microti, and Anaplasma phagocytophila in Ixodes scapularis ticks collected in Northern New Jersey. (8/65)

The American Journal of Tropical Medicine and Hygiene | Experimental Babesia Microti Infections in Macaca Mulatta: Recurrent...

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Bob Cowarts Blog: Genetic diversity of Babesia microti

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Theileria microti - Wikipedia

Babesia microti IgG Antibodies, Serum - Providence Alaska Medical Center

Author: Chen, Jia-Xu / Publication Year: 2018 / Subject: public health / Text Availability: Full Text - PubAg Search Results

Flesh and Bones: BABESIA MICROTI

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