A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Form of adoptive transfer where cells with antitumor activity are transferred to the tumor-bearing host in order to mediate tumor regression. The lymphoid cells commonly used are lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL). This is usually considered a form of passive immunotherapy. (From DeVita, et al., Cancer, 1993, pp.305-7, 314)
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Therapies that involve the TRANSPLANTATION of CELLS or TISSUES developed for the purpose of restoring the function of diseased or dysfunctional cells or tissues.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A member of the tumor necrosis factor receptor superfamily found on mature B-LYMPHOCYTES. It has specificity for B CELL ACTIVATING FACTOR and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.
A tumor necrosis factor receptor superfamily member found expressed on peripheral B-LYMPHOCYTES. It has specificity for B-CELL MATURATION ANTIGEN and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13.
Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)
A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN.
A member of the tumor necrosis factor receptor superfamily that specifically binds B-CELL ACTIVATING FACTOR. It is found on B-LYMPHOCYTES and plays a role in maturation and survival of B-cells. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
A protozoan parasite of rodents transmitted by the mosquito Anopheles stephensi.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
An increase in circulating RETICULOCYTES, which is among the simplest and most reliable signs of accelerated ERYTHROCYTE production. Reticulocytosis occurs during active BLOOD regeneration (stimulation of red bone marrow) and in certain types of ANEMIA, particularly CONGENITAL HEMOLYTIC ANEMIA.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Physiologically inactive substances that can be converted to active enzymes.
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.
Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.

BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population. (1/82)

The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor-triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.  (+info)

Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. (2/82)

BLyS (also called TALL-1, THANK, or BAFF) [1] [2] [3] [4] is a member of the tumor necrosis factor (TNF) gene family that stimulates proliferation and immunoglobulin production by B cells. BLyS interacts with the TNF receptor (TNFR) homologue TACI (transmembrane activator and CAML-interactor) [5], and treatment of mice with a TACI-Fc fusion protein abolishes germinal center formation after antigenic challenge [6]. Here we report a novel interaction between BLyS and another TNFR homologue, BCMA (B cell maturation antigen) [7] [8]. Further, the TNF homologue APRIL [9], a close relative of BLyS, also bound to BCMA and TACI. BLyS or APRIL activated nuclear factor-kappaB (NF-kappaB) through TACI and BCMA, and each ligand stimulated immunoglobulin M (IgM) production by peripheral blood B cells. These results define a dual ligand-receptor system that may play an important role in humoral immunity.  (+info)

TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. (3/82)

BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes. Previously, we reported in a human malignant myeloma cell line that BCMA is not primarily present on the cell surface but lies in a perinuclear structure that partially overlaps the Golgi apparatus. We now show that in transiently or stably transfected cells, BCMA is located on the cell surface, as well as in a perinulear Golgi-like structure. We also show that overexpression of BCMA in 293 cells activates NF-kappa B, Elk-1, the c-Jun N-terminal kinase, and the p38 mitogen-activated protein kinase. Coimmunoprecipitation experiments performed in transfected cells showed that BCMA associates with TNFR-associated factor (TRAF) 1, TRAF2, and TRAF3 adaptor proteins. Analysis of deletion mutants of the intracytoplasmic tail of BCMA showed that the 25-aa protein segment, from position 119 to 143, conserved between mouse and human BCMA, is essential for its association with the TRAFs and the activation of NF-kappa B, Elk-1, and c-Jun N-terminal kinase. BCMA belongs structurally to the TNFR family. Its unique TNFR motif corresponds to a variant motif present in the fourth repeat of the TNFRI molecule. This study confirms that BCMA is a functional member of the TNFR superfamily. Furthermore, as BCMA is lacking a "death domain" and its overexpression activates NF-kappa B and c-Jun N-terminal kinase, we can reasonably hypothesize that upon binding of its corresponding ligand BCMA transduces signals for cell survival and proliferation.  (+info)

B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. (4/82)

TALL-1 is a recently identified member of the tumor necrosis factor (TNF) family that costimulates B lymphocyte proliferation. Here we show that B cell maturation protein (BCMA), a member of the TNF receptor family that is expressed only by B lymphocytes, specifically binds to TALL-1. A soluble receptor containing the extracellular domain of BCMA blocks the binding of TALL-1 to its receptor on the plasma membrane and inhibits TALL-1-triggered B lymphocyte costimulation. Overexpression of BCMA activates NF-kappaB, and this activation is potentiated by TALL-1. Moreover, BCMA-mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor-associated factor 5 (TRAF5), TRAF6, NF-kappaB-inducing kinase (NIK), and IkappaB kinase (IKK). These data indicate that BCMA is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of BCMA as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases.  (+info)

A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. (5/82)

A proliferation-inducing ligand (APRIL) is a ligand of the tumor necrosis factor (TNF) family that stimulates tumor cell growth in vitro and in vivo. Expression of APRIL is highly upregulated in many tumors including colon and prostate carcinomas. Here we identify B cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI), two predicted members of the TNF receptor family, as receptors for APRIL. APRIL binds BCMA with higher affinity than TACI. A soluble form of BCMA, which inhibits the proliferative activity of APRIL in vitro, decreases tumor cell proliferation in nude mice. Growth of HT29 colon carcinoma cells is blocked when mice are treated once per week with the soluble receptor. These results suggest an important role for APRIL in tumorigenesis and point towards a novel anticancer strategy.  (+info)

B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. (6/82)

B-cell maturation protein (BCMA) is a member of the tumor necrosis factor (TNF) receptor family and is expressed in B lymphocytes. BCMA binds two TNF family members, BAFF and APRIL, that stimulate cellular proliferation. BAFF in particular has been shown to influence B-cell survival and activation, and transgenic mice overexpressing BAFF have a lupus-like autoimmune disorder. We have inactivated BCMA in the mouse germ line. BCMA(-/-) mice have normal B-cell development, and the life span of mutant B lymphocytes is comparable to that of wild-type B cells. The humoral immune responses of BCMA(-/-) mice to T-cell-independent antigens as well as high and low doses of T-cell-dependent antigens are also intact. In addition, mutant mice have normal splenic architecture, and germinal centers are formed during an ongoing immune response. These data suggest a functional redundancy of BCMA in B-cell physiology that is probably due to the presence of TACI, another TNF receptor family member that is expressed on B cells and that can also bind BAFF and APRIL.  (+info)

An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. (7/82)

The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.  (+info)

BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. (8/82)

B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.  (+info)

Multiple myeloma is a malignant plasma cell disorder diagnosed annually in approximately 86,000 participants worldwide. JNJ-68284528 is an autologous chimeric antigen receptor T-cell (CAR-T) therapy that targets B-cell maturation antigen (BCMA), a molecule expressed on the surface of mature B lymphocytes and malignant plasma cells. The primary hypothesis for this study is that JNJ-68284528 will significantly improve progression free survival (PFS) compared with standard therapy (PVd or DPd), in participants who have previously received 1 to 3 prior line(s) of therapy, that included a proteasome inhibitor (PI) and an immunomodulatory drug (IMiD) and who are refractory to lenalidomide. This study will be conducted in 3 phases: Screening (up to 28 days before randomization), Treatment, and Follow-Up. Assessment like patient-reported outcome(s) (PROs) assessments, electrocardiogram (ECG), vital signs, pharmacokinetic will be performed during the study. Safety evaluations will include review of ...
Chimeric antigen receptor (CAR) T cell therapy has demonstrated proven efficacy in some hematologic cancers. We evaluated the safety and efficacy of LCAR-B38M, a dual epitope-binding CAR T cell therapy directed against 2 distinct B cell maturation antigen epitopes, in patients with relapsed/refractory (R/R) multiple myeloma (MM). This ongoing phase 1, single-arm, open-label, multicenter study enrolled patients (18 to 80 years) with R/R MM. Lymphodepletion was performed using cyclophosphamide 300 mg/m2. LCAR-B38M CAR T cells (median CAR+ T cells, 0.5 × 106 cells/kg [range, 0.07 to 2.1 × 106]) were infused in 3 separate infusions. The primary objective is to evaluate the safety of LCAR-B38M CAR T cells; the secondary objective is to evaluate the antimyeloma response of the treatment based on the general guidelines of the International Myeloma Working Group. At data cutoff, 57 patients had received LCAR-B38M CAR T cells. All patients experienced ≥ 1 adverse events (AEs). Grade ≥ 3 AEs were reported
The purpose of this pilot study is to test the safety and efficacy of giving targeting CD138 or B-cell maturation antigen T cells in treating patients with
Photo: Pixabay prnewswire.com The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data for ciltacabtagene autoleucel (cilta-cel), an investigational B-cell maturation antigen (BCMA)-directed CAR-T therapy, demonstrated sustained efficacy and durable responses in heavily pretreated patients with relapsed/refractory multiple myeloma (RRMM). Updated results from the Phase 1b/2 CARTITUDE-1 study (n=97) with a longer-term follow-up at a median of 18 months showed an overall response rate (ORR) of 98 percent, with 80 percent of patients achieving a stringent complete response (sCR), highlighting a deepening response over time (increasing from 67 percent presented at ASH 2020).1 These data also showed 66 percent of patients were progression free and alive at 18 months (95 percent Confidence Interval [CI], range, 54.9–75.0). The latest findings to be presented at the American Society of Clinical Oncology (ASCO) Annual Meeting, showed an overall survival
ADC molecules are engineered to deliver potent cytotoxic compounds to specific antigen-expressing target cells.1,2 Antigen binding domains recognize specific surface proteins, such as B-cell maturation antigen (BCMA), which allows for targeting of cells expressing BCMA, such as plasma and multiple myeloma cells .1,2 ADCs built with non-natural amino acid linkers could potentially ensure that the cytotoxic payload reaches the target cell.1,3 Cytotoxic molecules induce cell death when internalized by antigen-expressing target cells.3 Preclinical studies have shown that ADCs can attack tumors directly, independent of the immune system.4 Preclinical studies are ongoing to optimize, improve, and assess the potential benefits and risks of ADCs as single agent therapy or in combination with other therapies.3,5. ...
The use of monoclonal antibodies (mab) can in some cases interfere with the follow-up of MM during the assay protein electrophoresis. The thesis presents some new methods for differentiating the two immunoglobulins making correct follow-up of the disease possible. Other methods presented are new biomarkers such as B-cell maturation antigen (BCMA) and the ratio between the monocyte count and lymphocyte count, a ratio you get from the complete blood count. BCMA seems to be a promising biomarker but more research is needed before conclusions can be made about the leukocyte ratios as biomarkers because different results have been reported in articles ...
During this years annual meeting, Seattle Genetics and Unum Therapeutics presented pre-clinical data evaluating combination treatment with Antibody-Coupled T cell Receptor (ACTR) engineered autologous T cells and an antibody targeting B-cell maturation antigen or BCMA.. The ACTR technology enables the programming of a patients immune system to attack tumor cells when co-administered with tumor-specific therapeutic antibodies. The pre-clinical data support clinical evaluation of a humanized non-fucosylated anti-BCMA antibody, known as SEA-BCMA, being developed using Seattle Genetics novel sugar-engineered antibody (SEA) technology, and ACTR T cell combination treatment in multiple myeloma patients.. Designed to engage the Fc domain of therapeutic antibodies, the ACTR technology, is a universal, engineered T cell therapy consisting of the extracellular domain of human CD16 and the intracellular T cell co-stimulatory and signal domain.. One presentation highlighted data from pre-clincal studies ...
Acronyms and Abbreviations: ALL, acute lymphatic leukemia; BCMA, B-cell maturation antigen; CAR, chimeric antigen receptor; cDNA, complementary DNA; CDR3, complementarity determining region 3; CEA, carcinoembryonic antigen; CLL, chronic lymphatic leukemia; CMV, cytomegalovirus; CRS, cytokine release syndrome; CTL, cytotoxic T lymphocyte; DLI, donor lymphocyte infusion; E, early viral protein; EBV, Epstein-Barr virus; EGFR, epidermal growth factor receptor; ERBB2IP, erbb2 interacting protein; GD2, disialoganglioside; GVHD, graft-versus-host disease; GVL, graft-versus-leukemia; HHV-6, human herpes virus-6; HLA, human leukocyte antigen; HSCT, hematopoietic stem cell transplantation; HSV, herpes simplex virus; HSV-TK, herpes simplex virus thymidine kinase; iCasp9, inducible caspase-9; IE, immediate early viral protein; IFN-γ, interferon-γ; IL, interleukin; L1CAM, L1-cell adhesion molecule; LCL, lymphoblastoid cell line; LPD, lymphoproliferative disease; mAbs, monoclonal antibodies; mHAgs, minor ...
Monoclonal and Bispecific Anti-BCMA Antibodies in A number of Myeloma B-cell maturation antigen (BCMA), a member of the tumor […]. Read more → ...
Update-1 BLUE Drops 1.96% and 1.77% After Hours 6/3 In the bubbly CAR-T world bluebird bio (BLUE) and Celgene announced a deal for for development of product candidates for B-cell maturation antigen (BMCA) utilizing bluebird bioss gene therapy technology to modify a patients own T-Cells to target cancer cells. A $25M up-front payment was made but […]. ...
BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We conducted a phase I study of autologous T cells lentivirally transduced with a fully human, BCMA-specific CAR containing CD3ζ and 4-1BB signaling domains (CART-BCMA), in subjects with relapsed/refractory MM. Twenty-five subjects were treated in 3 cohorts as follows: cohort 1, 1 × 108 to 5 × 108 CART-BCMA cells alone; cohort 2, cyclophosphamide (Cy) 1.5 g/m2 plus 1 × 107 to 5 × 107 CART-BCMA cells; cohort 3, Cy 1.5 g/m2 plus 1 × 108 to 5 × 108 CART-BCMA cells. No prespecified BCMA expression level was required. RESULTS. CART-BCMA cells were manufactured and expanded in all subjects. Toxicities included cytokine release syndrome and neurotoxicity, which were grade 3-4 in 8 (32%) and 3 (12%) subjects, respectively, and reversible. One subject died at day 24 from candidemia and progressive myeloma, following treatment for ...
BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We conducted a phase I study of autologous T cells lentivirally transduced with a fully human, BCMA-specific CAR containing CD3ζ and 4-1BB signaling domains (CART-BCMA), in subjects with relapsed/refractory MM. Twenty-five subjects were treated in 3 cohorts as follows: cohort 1, 1 × 108 to 5 × 108 CART-BCMA cells alone; cohort 2, cyclophosphamide (Cy) 1.5 g/m2 plus 1 × 107 to 5 × 107 CART-BCMA cells; cohort 3, Cy 1.5 g/m2 plus 1 × 108 to 5 × 108 CART-BCMA cells. No prespecified BCMA expression level was required. RESULTS. CART-BCMA cells were manufactured and expanded in all subjects. Toxicities included cytokine release syndrome and neurotoxicity, which were grade 3-4 in 8 (32%) and 3 (12%) subjects, respectively, and reversible. One subject died at day 24 from candidemia and progressive myeloma, following treatment for ...
Belantamab mafodotin, also known as GSK2857916, is an investigational anti-TNFRSF17 (TNF receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, B cell maturation antigen, BCMA, BCM, TNFRSF13A, CD269)], humanized monoclonal antibody conjugated, on an average of 4 cysteinyl, to monomethyl auristatin F (MMAF), via a noncleavable maleimidocaproyl (mc) linker.
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SUMMIT, N.J. & CAMBRIDGE, Mass.-(BUSINESS WIRE)- Celgene Corporation (NASDAQ: CELG) and bluebird bio, Inc. (Nasdaq: BLUE) today announced that updated results from the ongoing CRB-401 Phase 1 clinical study of bb2121, an investigational anti-B-cell maturation antigen (BCMA) CAR T cell therapy, in 21 patients with late-stage relapsed/refractory multiple myeloma will be presented in an oral presentation …. ...
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A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN ...
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The samples used in this paper were obtained from patients with osteoarthritis (OA) or RA during knee-TEP operations. First of all, expression of the known BAFF-binding receptors BCMA, TACI and BAFF-R was analyzed in SF of patients with OA and RA using flow cytometry and immunohistochemistry. In a further step, the influence of several stimulants, including cytokines, TLR-agonists and cell activators on receptor expression was tested. Finally, taking into account BAFF function in other cell types, SF were stimulated with BAFF and stained with Annexin V in order to analyze its effect on apoptosis in SF ...
EGT1442 BAFF or Apr can induce activation sign in THP-1 cells which react to the excitement via production of the cytokine, IL-8, or a matrix degrading enzyme, MMP-9 (9,10). The siBAFF-transfected cells were EGT1442 tested for the responsiveness to BAFF or APRIL-mediated signaling then. As demonstrated in Fig. 2A, cells transfected with control siRNA taken care of immediately both anti-APRIL and anti-BAFF mAb and expressed large degrees of IL-8. Cells transfected with siBAFF didnt respond to the procedure with anti-BAFF mAb but taken care of immediately anti-APRIL mAb at a rate just like LPS response. The siBAFF-transfected cells had been after that treated with real estate agents that imitate its counterparts such as for example fusion protein including extracellular site of TACI (or BCMA) and Fc MYO5A part of human being immunoglobulin (TACI:Fc or BCMA:Fc). As demonstrated in Fig. 2A, both TACI:Fc and BCMA:Fc activated the cells expressing IL-8 at a rate slightly significantly less than that ...
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अपनी कालगणना का हम सतत स्मरण करते हैं किन्तु हमें ध्यान नहीं रहता है। जब हम किसी नये व्यक्ति से मिलते हैं तो उसे अपना परिचय देते हैं कि अमुक देश, प्रदेश, या गांव के निवासी हैं, अमुक पिता की संतान है। इसी प्रकार जब हम किसी शुभ कार्य का संपन्न करन के लिए किसी देव शक्ति का आवाहन करते हैं तो उसे संकल्प करते समय अपना परिचय बताते हैं। संकल्प के समय पुरोहितगण एक मंत्र बोलते हैं, जिस पर हम विशेष ...
Translation of caries | The most common chronic disease of childhood is early childhood caries (dental caries in children younger than six years
B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF ligand superfamily member and has been designated TNFSF13B. It is produced by macrophages, dendritic cells, and T lymphocytes. BAFF promotes the survival of B cells and is essential for B cell maturation (1‑4). BAFF binds to three TNF receptor superfamily members: B‑cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF-R selectively binds BAFF. Mouse BAFF-R cDNA encodes a 175 amino acid residue (aa) transmembrane protein with a 71 aa extracellular domain, a 21 aa transmembrane domain, and a 83 aa cytoplasmic region. A second isoform of BAFF R that has a 72 aa cytoplamic region can also be ...
Circulating endothelial progenitor cells (EPCs) are biologic markers of endothelial function. In patients with systemic lupus erythematosus (SLE), the numerical reduction and functional impairment of EPCs contribute to the endothelial dysfunction. Through ex vivo and in vitro studies, we aimed at evaluating the effects of B lymphocyte stimulator (BLyS) on EPC colonies and endothelial cells and also investigating BLyS receptor expression on these cells. EPCs were isolated from peripheral blood mononuclear cells (PBMC). In order to evaluate their ability to form colonies, EPCs were cultured on fibronectin-coated dishes and incubated with BlyS alone or BlyS and belimumab. Apoptosis of EPCs and endothelial cell line EA.hy926 was evaluated after 6, 12, and 24 h of incubation with BLyS and after 6 h with BLyS and belimumab. The expression of B cell activating factor-receptor (BAFF-R), B cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor
A Tumor Necrosis Factor superfamily member that plays a Role in the Regulation of B-Lymphocyte Survival. It occurs as a Membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to Transmembrane Activator and CAML Interactor Protein; B-Cell Activation Factor Receptor; and B-Cell Maturation Antigen ...
CD268 (BAFF Receptor), clone: 8A7, eBioscience™ 25μg; Unconjugated CD268 (BAFF Receptor), clone: 8A7, eBioscience™ Primary Antibodies CD251 to CD400
CD268 (BAFF Receptor), PE, clone: 8A7, eBioscience™ 100 Tests; PE CD268 (BAFF Receptor), PE, clone: 8A7, eBioscience™ Primary Antibodies CD251 to CD400
BAFF receptor (BAFF = B cell-activating factor of the TNF family) is a main pro-survival receptor expressed by human B cells. BAFFR deficiency is caused by a homologous deletion within the BAFFR gene...
Complete information for FAF2 gene (Protein Coding), Fas Associated Factor Family Member 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Background The TNF superfamily member B lymphocyte stimulator (BLyS), referred to as BAFF, is known to be an effective modulator of peripheral B cell homeostasis that promotes B cell survival and differentiation. BLyS is expressed by a few stromal cells, T cells, and most myeloid cell. BLyS transgenic mice show an expansion of the peripheral mature B cell compartment, hyperglobulinemia, anti-single-stranded DNA and anti-double-stranded DNA antibodies, and circulating immune complexes. A proliferation-inducing ligand (APRIL) is a homolog to BLyS that is expressed by monocytes, macrophages, DCs, T cells, and others. APRIL is virtually undetectable in normal tissues but is strongly expressed in adenocarcinomas and can accelerate the growth of malignant cells in vitro and in vivo. APRIL/BLyS heterotrimers are present in the serum of patients with systemic autoimmune diseases like rheumatoid arthritis (RA), SLE, and SS. APRIL over expression promotes a strong survival signal for both CD4+ and CD8+ T ...
Toda la información sobre las últimas publicaciones científicas de la Clínica Universidad de Navarra. Increased expression of A Proliferation-inducing Ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non small cell lung cancer
The development and antigen-dependent differentiation of B lymphocytes are orchestrated by an array of growth factors, cytokines, and chemokines that require tight spatiotemporal regulation. Heparan sulfate proteoglycans specifically bind and regulate the bioavailability of soluble protein ligands, but their role in the immune system has remained largely unexplored. Modification of heparan sulfate by glucuronyl C5-epimerase (Glce) controls heparan sulfate-chain flexibility and thereby affects ligand binding. Here we show that Glce deficiency impairs B-cell maturation, resulting in decreased plasma cell numbers and immunoglobulin levels. We demonstrate that C5-epimerase modification of heparan sulfate is critical for binding of a proliferation inducing ligand (APRIL) and that Glce-deficient plasma cells fail to respond to APRIL-mediated survival signals. Our results identify heparan sulfate proteoglycans as novel players in B-cell maturation and differentiation and suggest that heparan sulfate ...
Naive peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.
The monoclonal antibody 11C1 reacts with the B cell-activating factor receptor (BAFF-R), also known as BAFF receptor 3 (BR3) or CD268. It is a 19 kDa type III transmembrane protein which belongs to the TNF receptor superfamily and is mainly expressed on B cells. BAFF-R plays an important role in B cell differentiation and promotes survival and activation of B cells. - Belgique
The principle role of the company is to identify, to verify the validity and ultimately to offer a range of biochemical assays each of which will provide unique and informative results to the condition of an individual patient from which the physician can
There are comments on PubPeer for publication: Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen (2010)
A Proliferation Inducing Ligand (APRIL) is a TNF ligand that, via its receptors TACI and BCMA, is involved in both B cell physiology as well as in proliferation and survival of malignant B cells. To target APRIL-dependent stimulation of B cell cancers, we recently produced and characterized two monoclonal antagonistic anti-human APRIL antibodies called humanAPRIL.01A (hA.01A) and humanAPRIL.03A (hA.03A). In a first biochemical assay to validate their blocking activity, hA.01A was shown to fully prevent APRIL from binding to its receptors, whereas a substantial difference was detected for hA.03A, which inhibited APRIL binding to BCMA less efficiently than hA.01A. Epitope mapping subsequently revealed that hA.01A and hA.03A bind distinct sites on APRIL, which provided a structural rationale of their different blocking activities. Importantly, this differential inhibition profile can be used to functionally dissect BCMA and TACI-dependent signals and indicated that B cell survival and IgA ...
Είναι το τελευταίο ποίημα του Σεφέρη και δημοσιεύτηκε στο Βήμα (23.9.71) τρεις μέρες μετά το θάνατό του στην περίοδο της δικτατορίας. Το ποίημα βασίζεται σε μια περικοπή του Πλάτωνα (Πολιτεία 614 κ.ε.) που αναφέρεται στη μεταθανάτια τιμωρία των αδίκων και ιδιαίτερα του Αρδιαίου. Ο Αρδιαίος, τύραννος σε μια πόλη, είχε σκοτώσει τον πατέρα του και τον μεγαλύτερο του αδερφό του. Γι αυτό και η τιμωρία του, καθώς και των άλλων τυράννων, στον άλλο κόσμο στάθηκε φοβερή. Όταν εξέτισαν την καθιερωμένη ποινή που επιβαλλόταν στους αδίκους και ετοιμαζόταν να βγουν στο ...
Tumor Necrosis Factor Ligand Superfamily Member 13: A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.
B cell-activating factor belonging to the TNF family (BAFF) and its receptor BAFF-R play critical roles in the maturation and survival of conventional peripheral B cells. However, they appeared to be dispensable for the generation and maintenance of CD5(+) B-1 cells as BAFF(-/-) and BAFF-R(-/-) mice have normal B-1 cell populations. Hence, it is presently unclear if B-1 cells are responsive to BAFF and if BAFF regulates some aspects of B-1 cell function. We show here that BAFF-R and transmembrane activator and CAML interactor (TACI) are the major receptors expressed by B-1 cells. Specifically, we show that BAFF treatment of B-1 cells leads to increased NF-kappaB p100 processing and CD21/CD35 expression. Interestingly, toll-like receptor (TLR) engagement of B-1 cells augmented the surface expression of BAFF receptors and rendered them responsive to BAFF costimulation, as evidenced by their increased proliferation, expression of cell surface activation markers and secretion of the pro-inflammatory
BCMA Antibody Drug Conjugate Active in Patients With Heavily Pretreated Myeloma - ASH Annual Meeting, Multiple Myeloma, On Location - ASH Clinical News
BAFF大鼠单克隆抗体[Buffy 2](ab16081)可与小鼠, 人样本反应并经WB, IHC, Flow Cyt实验严格验证,被13篇文献引用。所有产品均提供质保服务,中国75%以上现货。
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Looking for online definition of heat-shock transcription factor family member 5 in the Medical Dictionary? heat-shock transcription factor family member 5 explanation free. What is heat-shock transcription factor family member 5? Meaning of heat-shock transcription factor family member 5 medical term. What does heat-shock transcription factor family member 5 mean?
Results The mean disease duration of SLE was 7,0 [2,0-10,0] years, SLEDAI 2K score - 4 [2-13], SLICC damage index score - 0 [0-1], current prednisone dose - 10,0 [7,5-25,0] mg/day. SLE pts did not differ from healthy controls in BAFF (0,02 [0,02-0,08] vs 0,02 [0,02-0,02] ng/ml) and APRIL (0,01 [0,01-0,62] vs 0,01 [0,01-0,01] ng/ml) levels. Among SLE pts BAFF level correlated with lupus anticoagulant (r=0,88, p,0,05) and ESR (r=0,43, p,0,05); APRIL level correlated with SLEDAI 2K (r=0,55, p,0,01), CRP (r=0,50, p,0,01), antiDNA (r=0,38, p,0,05), creatinine level (r=0,39, p,0,05), current prednisone dose (r=0,55, p,0,01) and CD19 B lymphocytes absolute count (r=0,89, p,0,05). We divided SLE pts on two groups: the 1st- pts with high activity (SLEDAI 2K≥8), the 2nd - pts with low (SLEDAI 2K,8). The patients of 1st group had higher level of APRIL (1,69 [0,01-4,0] vs 0,01 [0,01-0,01] ng/ml, p,0,05) compared to 2nd group and control, there is no difference in BAFF level in these groups.. ...
BAFF and APRIL are innate immune mediators that trigger immunoglobulin G (IgG) and IgA class-switch recombination (CSR) in B cells by engaging the receptor TACI. The mechanism that underlies CSR signaling by TACI remains unknown. Here we found that the cytoplasmic domain of TACI encompasses a conserved motif that bound MyD88, an adaptor that activates transcription factor NF-kappaB signaling pathways via a Toll-interleukin 1 (IL-1) receptor (TIR) domain. TACI lacks a TIR domain, yet triggered CSR via the DNA-editing enzyme AID by activating NF-kappaB through a Toll-like receptor (TLR)-like MyD88-IRAK1-IRAK4-TRAF6-TAK1 pathway. TACI-induced CSR was impaired in mice and humans lacking MyD88 or the kinase IRAK4, which indicates that MyD88 controls a B cell-intrinsic, TIR-independent, TACI-dependent pathway for immunoglobulin diversification. ...
Dive into the research topics of Transmembrane activator and CAML interactor (TACI) haploinsufficiency results in B-cell dysfunction in patients with Smith-Magenis syndrome. Together they form a unique fingerprint. ...
Introduction Blisibimod is a potent B cell-activating aspect (BAFF) antagonist that binds to both cell membrane-expressed and soluble BAFF. B cells reverted to baseline, resulting in a calculated 30 percent30 % decrease in total B cells by around 160 days following the 1st dosage. In both solitary- and multiple-dosing SC cohorts, the pharmacokinetic profile indicated sluggish absorption, dose-proportional publicity from 0.3 through 3.0 mg/kg SC and 1 through 6 mg/kg IV, linear pharmacokinetics over the dosage selection of 1.0C6.0 mg/kg, and accumulation ratios which range from 2.21 to 2.76. The comparative increase in memory space B cells had not been associated with security signals, as well as the 1192500-31-4 supplier occurrence of adverse occasions, anti-blisibimod antibodies, and medical laboratory abnormalities had been similar between blisibimod- and placebo-treated topics. Conclusions Blisibimod transformed the constituency from the B cell pool and solitary and multiple dosages of ...
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SED021Mu, FTH1; FTHL6; PIG15; PLIF; Ferritin Heavy Chain; Apoferritin; Placenta Immunoregulatory Factor; Proliferation-Inducing Protein 15; Cell proliferation-inducing gene 15 protein | Products for research use only!
Transducer of ErbB-2, 1 (TOB1) is an antiproliferative factor that belongs the tob/btg1 family. TOB1 and TOB2 have the ability to suppress cell growth in cell culture. TOB1 is phosphorylated by ribosomal S6 serine/threonine kinase. It interacts with ErbB-2 and interferes with growth suppression in B cells. TOB1 also inhibits T cell proliferation and the transcription of some cytokines, including interleukin 2 (IL-2). TOB1 is also known as TROB1, TROB, TOB, APRO6, and proliferation-inducing gene 49 (PIG49).. ...
Transducer of ErbB-2, 1 (TOB1) is an antiproliferative factor that belongs the tob/btg1 family. TOB1 and TOB2 have the ability to suppress cell growth in cell culture. TOB1 is phosphorylated by ribosomal S6 serine/threonine kinase. It interacts with ErbB-2 and interferes with growth suppression in B cells. TOB1 also inhibits T cell proliferation and the transcription of some cytokines, including interleukin 2 (IL-2). TOB1 is also known as TROB1, TROB, TOB, APRO6, and proliferation-inducing gene 49 (PIG49).. ...
Anyone who has ever prepared a meal with a process called sous vide, which involves putting ingredients in a plastic pouch and cooking them, raves about the wonderful tastes that result.There is
"The Fasciola hepatica Tegumental Antigen Suppresses Dendritic Cell Maturation and Function". Infection and Immunity. 77 (6): ... These cells are modified parenchyme cells. In F. hepatica, their role is to perform excretion, but more importantly, ... This means it is made from the fusion of many cells, each containing one nucleus, to produce a multinucleated cell membrane. In ... Instead, the nuclei are found in the cell bodies, also known as tegumental cells, these connect to the outer cytoplasm via thin ...
Cells in the lymphatic system react to antigens presented or found by the cells directly or by other dendritic cells. When an ... Bone marrow is responsible for both the creation of T cells and the production and maturation of B cells. From the bone marrow ... Mature T cells join B cells in search of pathogens. The other 95% of T cells begin a process of apoptosis, a form of programmed ... The lymph transports antigen-presenting cells, such as dendritic cells, to the lymph nodes where an immune response is ...
... the maturation process is finalized and can leave to infect additional cells. A dipeptide of two lysine residues (dilysine) was ... Group-specific antigen (gag) proteins are major components of the viral capsid. Protease performs proteolytic cleavages during ... SFV can infect a wide range of cells, with in vitro experiments confirming that fibroblasts, epithelial cells, and neural cells ... Cells that expressed no signs of cytopathy from SFV were the Jurkat and Hut-78 T-cell lines. The phylogenetic tree analysis of ...
T-cells can be made non-responsive to antigens presented if the T-cell engages an MHC molecule on an antigen presenting cell ( ... upon maturation (for example during the infection) DCs largely lose their tolerogenic capabilities. Aside from dendritic cells ... B cell peripheral tolerance is much less studied and is largely mediated by B cell dependence on T cell help. Antigens, which ... For example, tolerised T cells will not activate autoreactive B cells. Without this help from CD4 T cells, the B cells will not ...
Krangel MS, Orr HT, Strominger JL (December 1979). "Assembly and maturation of HLA-A and HLA-B antigens in vivo". Cell. 18 (4 ... In the absence of MHC class I, CD8 T cells cannot develop. (CD8 T cells are a subset of T cells involved in the development of ... "Lack of HLA class I antigen expression by melanoma cells SK-MEL-33 caused by a reading frameshift in beta 2-microglobulin ... deficient in the expression of HLA class I antigens on the cell surface". Cancer Research. 52 (5): 1201-4. PMID 1737380. Saper ...
Cells in the lymphatic system react to antigens presented or found by the cells directly or by other dendritic cells. When an ... Bone marrow is responsible for both the creation of T cell precursors and the production and maturation of B cells, which are ... to produce immune cells to fight antigens to remove particulate matter and aged blood cells, mainly red blood cells to produce ... Mature T cells then join B cells in search of pathogens. The other 95% of T cells begin a process of apoptosis, a form of ...
... and Class II Human leukocyte antigens. A subset of cells differentiates into Langerhans cells; this maturation occurs in the ... Langerhans cells are antigen-presenting cells but have undergone further differentiation. Skin Langerhans cells express CD1a, ... meaning cell). Histiocytes are derived from the bone marrow by multiplication from a stem cell. The derived cells migrate from ... They express LCAs (leucocyte common antigens) CD45, CD14, CD33, and CD4 (also expressed by T helper cells). These histiocytes ...
A major step in affinity maturation, somatic hypermutation helps B cells produce antibodies with greater antigen affinity. ... from normal cell to cancer cell. Cells with heterozygous loss-of-function mutations (one good copy of a gene and one mutated ... The mutation rate in antigen-binding coding sequences of the immunoglobulin genes is up to 1,000,000 times higher than in cell ... If a mutation occur in a somatic cell of an organism, it will be present in all descendants of this cell within the same ...
T cells, B-cells and memory cells are stimulated upon encountering antigen in Peyer's patches. These cells then pass to the ... The maturation of B-lymphocytes takes place in the Peyer's patch. Although important in the immune response, excessive growth ... M cells) which sample antigen directly from the lumen and deliver it to antigen-presenting cells (located in a unique pocket- ... Among the mononuclear cells, CD4+/CD25+ (10%) cells and CD8+/CD25+ (5%) cells are more abundant in Peyer's patches than in the ...
... which include dendritic cells (DCs) and macrophages. Immune complexes are better at inducing DC maturation than an antigen on ... B cells express B-cell receptors (BCRs) on their surfaces and antigen binding to these receptors begins a signaling cascade ... or cell death. After B cells are activated, they differentiate into plasma cells and cease to express BCR but continue to ... The bound antigen and antibody act as a unitary object, effectively an antigen of its own with a specific epitope. After an ...
15 kDa plays other roles in immunological processes, such as in antigen-presenting cell maturation and in immune cell migration ... Its expression is restricted to cytotoxic immune cells such as cytotoxic T cells, NK cells, NKT cells and γδ T cells. Orthologs ... such as NK cells, cytotoxic T cells, helper T cells, and in higher concentrations, immature dendritic cells. The 9 kDa form ... Granulysin is expressed in killer cells, such as cytotoxic T cells and Natural Killer (NK) cells, which hold the cytotoxic ...
... is a B-cell maturation antigen (BCMA)-directed genetically modified autologous chimeric antigen receptor ... CAR) T-cell therapy. Each dose is customized using a patient's own T-cells, which are a type of white blood cell, that are ... "FDA Approves First Cell-Based Gene Therapy for Adult Patients with Multiple Myeloma". U.S. Food and Drug Administration (FDA) ( ... It is the first cell-based gene therapy approved by the U.S. Food and Drug Administration (FDA) for the treatment of multiple ...
Rhinovirus uses protease 3C and 3D to induce cytopathetic effects in the host cell. 3C and 3D act similarly in rhinovirus as ... Hepatitis A 3C proteinase is a member of the cysteine proteases that are responsible for the infectivity and maturation of HAV ... This destruction of the secretory pathway reduces expression of major histocompatibility antigens at plasma membrane therefore ... For most of these viruses, 3C is necessary for cytopathetic effects on the host cell. So far, 3C protease inhibitors have been ...
"Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific ... "A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes ... April 2013). "Multiple interferon regulatory factor and NF-κB sites cooperate in mediating cell-type- and maturation-specific ... "Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83". ...
The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation ... "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nat. Immunol. 10 (8): ... This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. ... a T cell-specific protein important for late thymocyte development". Nat. Immunol. 10 (8): 840-7. doi:10.1038/ni.1768. PMC ...
Isotype expression reflects the maturation stage of a B cell. Naive B cells express IgM and IgD isotypes with unmutated ... and occurs after the B cell binds an antigen through its B cell receptor. Class-switching usually requires interaction with a T ... As IgM antibodies are expressed early in a B cell response, they are rarely highly mutated and have broad antigen reactivity ... IgM is first expressed as a monomer on the surface of immature B cells. Upon antigenic stimulation, IgM+ B cells secrete ...
It is known to play an important role in the maturation of T cell populations through activation of antigen presenting cells. ... stromal lymphopoietin converts human epidermal Langerhans cells into antigen-presenting cells that induce proallergic T cells ... dendritic cells. TSLP has also been shown to activate the maturation of a specific subset of dendritic cells located within the ... epithelial cells and different types of stromal or stromal-like cells.[citation needed] These cells are located in regions ...
Fcy receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen ... and display antigens to T cells, as well as how this process is regulated by regulatory T cells. Guermonprez P, Saveanu L... ... Amigorena's research focuses on antigen presentation by dendritic cells. In particular, Amigorena's research group has studied ... Journal of Cell Biology. 147(3): pgs. 599-610 Zitvogel L, Regnault A... Amigorena S (1998). Eradication of established murine ...
Mycobacterium leprae antigen-induced suppression of T cell proliferation in vitro. J. Immunol. 138:3028-3034. Sibley, L. D., L ... Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2!/calmodulin-PI3K hVPS34 cascade. J. Exp. Med. 198:653-659 ... J. Cell Biol. 154:631-644. Kaplan, G., R. R. Gandhi, D. E. Weinstein, W. R. Levis, M. E. Patarroyo, P. J. Brennan, and Z. A. ... Phosphatidylmyo-inositol Mannosides (PIMs) are a family of glycolipids found in the cell wall of Mycobacterium tuberculosis. ...
It occurs when the lymphocyte is activated by an antigen (from antigen-presenting cells) and increased in volume by nucleus and ... Although commonly lymphoblast refers to a precursor cell in the maturation of leukocytes, the usage of this term is sometimes ... Finally the dividing cells differentiate into effector cells, known as plasma cells (for B cells), cytotoxic T cells, and ... Blood cell lineage Acute lymphoblastic leukemia List of human cell types derived from the germ layers Janeway's Immunobiology, ...
In thymic epithelial cells, FOXN1 has been shown to bind to and regulate genes involved in T-cell maturation and antigen ... "Dedicated epithelial recipient cells determine pigmentation patterns". Cell. 130 (5): 932-42. doi:10.1016/j.cell.2007.07.024. ... "Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells". Nature Immunology. 17 ... A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail ...
"Novel afucosylated anti-B cell maturation antigen-monomethyl auristatin F antibody-drug conjugate (GSK2857916) induces potent ... It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells. MMAF is ... Monomethyl auristatin F is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. ...
"Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the ... Allman, DM; Ferguson, SE; Cancro, MP (15 October 1992). "Peripheral B cell maturation. I. Immature peripheral B cells in adults ... Antigen-specific NK cell memory first reported by Ulrich von Andrian's group after discovery by Mahmoud Goodarzi 2010 - The ... Discovery of the T cell antigen receptor TCR (Ellis Reinherz) (Philippa Marrack) and (John Kappler) (James Allison) 1983 - ...
This protein is involved in melanosome maturation. The gp100 protein is a melanoma antigen i.e. a tumor-associated antigen. ... In the mouse model, an HR-gp100-based vaccine triggered antigen-specific T cell responses, as shown by proliferation assays, ... "Transcutaneous immunization with hydrophilic recombinant gp100 protein induces antigen-specific cellular immune response". Cell ... It was demonstrated that HR-gp100 permeates into human skin, and is processed and presented by human dendritic cells. ...
... of excised DNA fragments which are generated during normal splicing of T-cell surface antigen receptors and T-cell maturation. ... B cells, natural killer cells, glial cells, and cells of the monocyte lineage, depending on the cell type and receptor ... is an immunodeficiency disorder in which the body produces very few T cells and NK cells. In the absence of T cell help, B ... Because these cells never receive these signals, they can never mature and differentiate into full grown immune cells. ...
B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell ... This is important during primary immune response, prior to affinity maturation, amplifying the response of low affinity BCRs to ... CAR-19 T cells are genetically modified T cells that express a targeting moiety on their surface that confers T cell receptor ( ... Paired box transcription factor 5 (PAX5) plays a major role in B cell differentiation from pro B cell to mature B cell, the ...
During maturation in the bone marrow, B cells are tested for interaction with self antigens, which is called negative selection ... Receptor editing is a process that occurs during the maturation of B cells, which are part of the adaptive immune system. This ... If the maturing B cells strongly interact with these self antigens, they undergo death by apoptosis. Negative selection is ... Halverson R, Torres RM, Pelanda R (2004). "Receptor editing is the main mechanism of B cell tolerance toward membrane antigens ...
However, there is only a limited repertoire of antigen that B cells can encounter within the thymus. B cell tolerance then must ... they are moved to the bone marrow where the maturation of B cells occurs. It is here where the first wave of B cell tolerance ... Tolerance is also produced in T cells. There are also various processes which lead to B cell tolerance. Just as in T cells, ... B cells that bind with low avidity to self-MHC receptors are positively selected for maturation, those that do not die by ...
... s (or Antigen-presenting cell activators) are a type of immunotherapy which leverages antigen-presenting cells ( ... APC Activators are agonists to APC surface-expressed ligands that, when bound, induce the maturation and activation of APCs. ... Professional antigen-presenting cells - including dendritic cells, macrophages, and B cells - serve an indispensable role in ... Hughes, Catherine E.; Benson, Robert A.; Bedaj, Marija; Maffia, Pasquale (2016). "Antigen-Presenting Cells and Antigen ...
Further information: Somatic hypermutation and Affinity maturation. Following activation with antigen, B cells begin to ... is an antigen found on red blood cells; individuals that are Rh-positive (Rh+) have this antigen on their red blood cells and ... B cell activation follows engagement of the cell-bound antibody molecule with an antigen, causing the cell to divide and ... Affinity maturation occurs in mature B cells after V(D)J recombination, and is dependent on help from helper T cells.[43] ...
... the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which are taken up by the B cell ... Since B cell maturation also involves somatic hypermutation (a process completed before differentiation into a plasma cell), ... Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete ... In humans, CD27 is a good marker for plasma cells, naive B cells are CD27-, memory B-cells are CD27+ and plasma cells are ...
2000). "Characterization of a new member of the TNF family expressed on antigen presenting cells.". Biol. Chem. 380 (12): 1443- ... "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". Proc. Natl. Acad. Sci. U.S.A. 97 ( ... "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.". Proc. Natl. Acad. Sci. U.S.A. 97 ... "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin ...
The cytotoxicity of Natural Killer (NK) cells and the antigen-presenting function of dendritic cells is known to diminish with ... which is the organ essential for T-cell maturation following the migration of precursor cells from the bone marrow. This age- ... which are specialized in facilitating peripheral B cell maturation, and the generation of antibody-producing plasma cells and ... The age-associated impairment of dendritic Antigen Presenting Cells (APCs) has profound implications as this translates into a ...
CD8+ cytotoxic T cells: T cells displaying co-receptor CD8 are known as CD8+ T cells. These cells bind antigens presented on ... T cells: *CD4+ helper T cells: T cells displaying co-receptor CD4 are known as CD4+ T cells. These cells have T-cell receptors ... B cells: releases antibodies and assists activation of T cells. *T cells: *CD4+ Th (T helper) cells: activate and regulate T ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ...
... the cell membrane degrades, becoming part of the host cell, and the RNA strands and enzymes enter the cell (3). Within the cell ... Group-specific antigen (gag) proteins are major components of the viral capsid, which are about 2000-4000 copies per virion. ... It functions in proteolytic cleavages during virion maturation to make mature gag and pol proteins. ... In this way some retroviruses can convert normal cells into cancer cells. Some provirus remains latent in the cell for a long ...
... because it is rapidly activated and does not require T cell help or clonal maturation and expansion. An example of TI-1 antigen ... TI-1 antigen[edit]. TI-1 antigens have an intrinsic B cell activating activity, that can directly cause proliferation and ... TI-1 antigen, which has an activity that can directly activate B cells and TI-2 antigen, which has highly repetitive structure ... TI-1 antigens are classified as B-cell mitogens, because they induce numerous cell divisions. In higher concentrations, TI-1 ...
LHCGR (Luteinizing hormone insensitivity, Leydig cell hypoplasia, Male-limited precocious puberty). *FSHR (Follicle-stimulating ... In females with KS/CHH, infertility is primarily due to the lack of maturation of eggs located within the ovaries. Ovulation ... haematocrit and prostate-specific antigen (PSA). If injections are used, trough levels are taken to ensure an adequate level of ... given at set intervals to trigger the maturation and release of the egg for natural conception.[37] ...
"The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle". Molecular Cell. 42 (5): 637-649. ... Peptide antigens are displayed by the major histocompatibility complex class I (MHC) proteins on the surface of antigen- ... "Cell. 137 (1): 133-45. doi:10.1016/j.cell.2009.01.041. PMC 2668214. PMID 19345192.. ... Cell cycle controlEdit. Cell cycle progression is controlled by ordered action of cyclin-dependent kinases (CDKs), activated by ...
T-independent antigen - Antigens that stimulate B cells directly.. *Immunodominant antigens - Antigens that dominate (over all ... Endogenous antigens[edit]. Endogenous antigens are generated within normal cells as a result of normal cell metabolism, or ... A native antigen is an antigen that is not yet processed by an APC to smaller parts. T cells cannot bind native antigens, but ... More common are antigens that are presented by tumor cells and normal cells, called tumor-associated antigens (TAAs). Cytotoxic ...
regulation of cell cycle. • cell division. • negative regulation of cell cycle arrest. • protein phosphorylation. • lens ... Goodpasture-antigen-binding protein kinase (EC 2.7.11.9). *-. IκB kinase (EC 2.7.11.10). *CHUK ... positive regulation of cell size. • positive regulation of apoptotic process. • regulation of gene expression. • cell cycle. • ... Ghavidel A, Cagney G, Emili A (2005). "A skeleton of the human protein interactome". Cell. 122 (6): 830-2. doi:10.1016/j.cell. ...
The antigen sensitivity is higher in antigen-experienced T cells than in naive T cells. Naive T cells pass through the process ... "Mechanisms behind functional avidity maturation in T cells". Clinical & Developmental Immunology. 2012: 163453. doi:10.1155/ ... Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells. ... binding affinity of TCR to MHC to prolong the cell-cell interaction between the antigen-presenting cell and the T cell. ...
FcεRI is expressed on mast cells, basophils, and the antigen-presenting dendritic cells in both mice and humans. Binding of ... The B lymphocyte differentiation and maturation pathway that eventually generate IgE-secreting plasma cells go through the ... Regulation of IgE levels through control of B cell differentiation to antibody-secreting plasma cells is thought to involve the ... those cells can be lysed or down-regulated, thus achieving the inhibition of the production of antigen-specific IgE and hence a ...
... has a 10-40-fold preference for hemimethylated DNA and interacts with the proliferating cell nuclear antigen (PCNA).[51] ... Predetermined epigenesis is a unidirectional movement from structural development in DNA to the functional maturation of the ... Costa S, Shaw P (March 2007). "'Open minded' cells: how cells can change fate" (PDF). Trends Cell Biol. 17 (3): 101-6. PMID ... Adult stem cells like bone marrow stem cells have also shown a potential to differentiate into cardiac competent cells when ...
gB, gD, gH, and gL proteins allow for fusion of the cell and envelope, and are necessary for survival. Entrance to host cells ... L genes are transcribed "after the synthesis of DNA and viral protein onset". Virion DNA maturation occurs as the nucleocapids ... be confirmed with presence of virus inclusion bodies in tissues or a positive immunohistochemical staining for viral antigen. ... DNA and proteins enter the host cell nucleus and turn-off host cell synthesis of nucleic acids, proteins, and other macro ...
cell maturation. • extrathymic T cell selection. • positive regulation of T cell proliferation. • regulation of defense ... Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated ... natural killer cell differentiation. • positive regulation of natural killer cell proliferation. • cell-cell signaling. • ... and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells ...
The ability of T cells to recognize foreign antigens is mediated by the T-cell receptor. The T-cell receptor undergoes genetic ... The medulla of the thymus is the site of T Cell maturation. Cells that pass both levels of selection are released into the ... Each T cell attacks a different antigen. T cells that attack the body's own proteins are eliminated in the thymus. Thymic ... Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin (derived from bone marrow ...
... they are professional antigen-presenting cells, they regulate other immune cell functions (e.g., CD4+ T cell, dendritic cell, B ... Mast cells[edit]. See article: Mast cell. Mast cells are a type of granulocyte that are present in tissues;[3] they mediate ... cell, mast cell, neutrophil, and basophil functions),[20] they are involved in the destruction of tumor cells,[16] and they ... Basophils are one of the least abundant cells in bone marrow and blood (occurring at less than two percent of all cells). Like ...
regulation of mitotic cell cycle. • intestinal epithelial cell maturation. • cellular response to ionizing radiation. • cell ... p21 interacts with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in ... G2/M transition of mitotic cell cycle. • positive regulation of B cell proliferation. • negative regulation of cell growth. • ... "Cell. 155 (2): 369-383. doi:10.1016/j.cell.2013.08.062. PMC 4001917. PMID 24075009.. ...
... expressed on cells destined for homing in cells to these organs). Using these ligands is possible routing antigen-presenting ... or guide cells to tissues that provide specific signals critical for cellular maturation. Other chemokines are inflammatory and ... Furthermore, CXCR3 expression by T-cells is induced following T-cell activation and activated T-cells are attracted to sites of ... Types by cell attractedEdit. *Monocytes / macrophages: the key chemokines that attract these cells to the site of inflammation ...
Dendritic cell apoptosis - immune system cells called dendritic cells present antigens to active lymphocytes. Dendritic cells ... T-Cell-B-Cell discordance - A normal immune response is assumed to involve B and T cell responses to the same antigen, even if ... The roles of specialized immunoregulatory cell types, such as regulatory T cells, NKT cells, γδ T-cells in the pathogenesis of ... T-Cell Bypass - A normal immune system requires the activation of B-cells by T-cells before the former can undergo ...
... cell loss from the seminiferous epithelium by disrupting cell adhesion function between nurse cells and immature sperm cells, ... Female mammals - Vaccine of antigens (derived from purified Porcine zona pellucida) encapsulated in liposomes (cholesterol and ... preventing maturation.. *Male mice - injection of a solution of the JQ1 molecule to bind to a pocket of BRDT necessary for ... "Cell. 150 (4): 673-684. doi:10.1016/j.cell.2012.06.045. PMC 3420011. PMID 22901802.. ...
Accurate diagnosis requires an antigen test or, if that is unavailable, an ova and parasite examination of stool. Multiple ... 2003). "Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation". Nature. 426 (6963): 172-6. ... Giardia cell, SEM Klasifikimi shkencor Domeni: Eukaryota Pa klasifikuar: Excavata Filumi: Metamonada ...
Chen C. H., Floyd H., Olson N. E., et al. Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation ... van Rhenen A., van Dongen G. A., Kelder A., et al. The novel AML stem cell associated antigen CLL-1 aids in discrimination ... Han Y., Zhang M., Li N., et al. KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity. ( ... Bakker A. B., van den Oudenrijn S., Bakker A. Q., et al. C-type lectin-like molecule-1: a novel myeloid cell surface marker ...
A critical difference between B cells and T cells is how each cell "sees" an antigen. T cells recognize their cognate antigen ... to the T cell-enriched lymph nodes. During migration, dendritic cells undergo a process of maturation in which they lose most ... Exogenous antigensEdit. Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells. ... T cells are useless without antigen-presenting cells to activate them, and B cells are crippled without T cell help. On the ...
The process of beta-cell destruction begins with insulitis activating antigen presenting cells (APCs). APCs then trigger ... After maturation, these secretory vesicles hold insulin, C-peptide, and amylin until calcium triggers exocytosis of the granule ... Beta cellscells) are a type of cell found in pancreatic islets that synthesize and secrete insulin and amylin. Beta cells ... Then the cytokines activate CD8+ cytotoxic-T cells, which lead to beta-cell destruction.[18] The destruction of these cells ...
This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may ... 1997). "A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3". Cytogenet. Cell Genet. 76 (3-4): 172-5. doi:10.1159 ... positive regulation of dendritic cell chemotaxis. • signal transduction. • calcium-mediated signaling. • chemotaxis. • cell ... positive regulation of epithelial cell migration. • dendritic cell chemotaxis. • cellular defense response. • humoral immune ...
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. „Nature". 389 (6652), s. 737-742, ... B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal ... Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells. „ ... Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming ...
cell surface receptor signaling pathway. • positive regulation of natural killer cell mediated cytotoxicity. • antigen ... LAG3 is known to be involved in the maturation and activation of dendritic cells.[21] ... LAG-3 is expressed on activated T cells,[11] natural killer cells,[6] B cells[12] and plasmacytoid dendritic cells.[13] ... cell membrane. Biological process. • negative regulation of T cell activation. • negative regulation of interleukin-2 ...
... a CAR-T Cell Therapy Directed Against B-Cell Maturation Antigen (BCMA), in Patients with Relapsed and/or Refractory Multiple ... B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a ... Shu HB, Johnson H (August 2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". ... Shu HB, Johnson H (August 2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". ...
Serum B-cell maturation antigen (sBCMA) is the cleaved form of B-cell maturation antigen (BCMA), found at low levels in the ... June 2019). "Serum B-cell maturation antigen (BCMA) reduces binding of anti-BCMA antibody to multiple myeloma cells". Leukemia ... "A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell ... Shah N, Chari A, Scott E, Mezzi K, Usmani SZ (April 2020). "B-cell maturation antigen (BCMA) in multiple myeloma: rationale for ...
T cell effectors (1 × 104, 2 × 102, and none) and 5 × 104 target cells (antigen-loaded mo-DCs, LCs, LCs/IFN-γ, or tumor cells) ... IFN-γ enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation. Mitsutoshi ... Cell Lines. HLA-A*0201+ mutant cell line T2 (CEMx721.174.T2), and NY-ESO-1+, HLA-A*0201+ melanoma cell lines SKMEL-37 and MZ- ... Maturation. To induce maturation, cells were incubated with lipopolysaccharide (LPS) (100 ng/ml, Sigma), IC, or CD40L (1 μg/ml ...
Quantification of B-cell maturation antigen, a target for novel chimeric antigen receptor T-cell therapy in myeloma. Leuk Res. ... B cell maturation antigen (BCMA) is a cell surface receptor expressed primarily by plasma cells. Its ligands are BAFF and APRIL ... T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma. Blood. ... T cells genetically modified to express an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of poor- ...
... and confirmed B-cell maturation antigen (BCMA) as a key myeloma-associated antigen. The aim of this study is to target the BCMA ... we have identified various antigens on CD138+ tumor cells from newly diagnosed MM patients (n = 616) ... which promotes MM cell growth and survival, by generating BCMA-specific memory CD8+ CTL that mediate effective and long-lasting ... of multiple B-cell maturation antigen-expressing hematological malignances by anti-B-cell maturation antigen chimeric antigen ...
CAR T cells are a promising therapy for hematologic malignancies. B cell maturation antigen (BCMA) is a rational target in ... B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. ... B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. ... Responses and CART-BCMA expansion were associated with CD4/CD8 T cell ratio and frequency of CD45RO-CD27+CD8+ T cells in the ...
B-Cell Maturation Antigen or TNFRSF17 or tumor necrosis factor receptor superfamily member 17, is part of the TNF receptor ... BCMA, CD269, Tumor Necrosis Factor Receptor Superfamily Member 17, BCM, TNFRSF17, B-cell maturation protein, CD269 antigen ... This protein is a TNFSF13B/BLyS/BAFF, TNFSF13/APRIL & promotes B-cell survival receptor. TNFRSF17 has a crucial part in the ...
Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen ... Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen ... Invariant NK T cells (iNKT) cells are a conserved population of innate-like T cells that recognize lipid antigens complexed to ... A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen- ...
Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma ... A Study of JNJ-68284528 a Chimeric Antigen Receptor T Cell (CAR-T) ... A Study of JNJ-68284528 a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in ... JNJ-68284528 is an autologous chimeric antigen receptor T-cell (CAR-T) therapy that targets B-cell maturation antigen (BCMA). ...
JNJ-68284528 is an autologous chimeric antigen receptor T-cell (CAR-T) therapy that targets B-cell maturation antigen (BCMA), a ... A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, ... A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, ... Any previous therapy that is targeted to B-cell maturation antigen (BCMA) ...
A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) ... A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) ... JNJ-68284528 is an autologous chimeric antigen receptor T-cell (CAR-T) therapy that targets B-cell maturation antigen (BCMA). ... Levels of B-Cell Maturation Antigen (BCMA) Expressing Cells and Soluble BCMA [ Time Frame: Up to 1 year ]. Levels of expression ...
Monophosphoryl lipid A plus IFNgamma maturation of dendritic cells induces antigen-specific CD8+ cytotoxic T cells with high ... Dendritic cells (DCs) are promising antigen presenting cells for cancer treatment. Previously, we showed that the combination ... Furthermore, the CTLs proved to kill tumour cells expressing endogenous tumour antigen in vitro. Therefore, MPLA/IFNgamma DCs ... amounts of induced CTLs are functional as they produce IFNgamma and lyse target cells and this cytolytic activity is antigen ...
Interaction of Mouse Dendritic Cells and Malaria-Infected Erythrocytes: Uptake, Maturation, and Antigen Presentation. Rebecca ... Red cells were lysed with NH4Cl lysing buffer. Cells were plated in 6-well plates at a concentration of 2.5 × 105 cells/ml in ... Interaction of Mouse Dendritic Cells and Malaria-Infected Erythrocytes: Uptake, Maturation, and Antigen Presentation ... In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J. Exp. Med. ...
... antigen recognition drives effector function development, where antigen naïve cells make IL-17 and antigen experienced cells ... Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced ... cells with prior antigen exposure produce IFNγ while cells that develop in the absence of ligand make IL-17. γδ T cells are the ... Thymic maturation determines γδ T cell function, but not their antigen specificities. Kirk D. C. Jensen1,2 and Yueh-hsiu Chien1 ...
Antigen-Processing Machinery in Human Dendritic Cells: Up-Regulation by Maturation and Down-Regulation by Tumor Cells. Theresa ... Antigen-Processing Machinery in Human Dendritic Cells: Up-Regulation by Maturation and Down-Regulation by Tumor Cells ... Antigen-Processing Machinery in Human Dendritic Cells: Up-Regulation by Maturation and Down-Regulation by Tumor Cells ... Antigen-Processing Machinery in Human Dendritic Cells: Up-Regulation by Maturation and Down-Regulation by Tumor Cells ...
... binds B cells and enhances B cell receptor-triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted ... B cell maturation antigen (BCMA) was first identified as part of a translocation event in a malignant T cell lymphoma patient ( ... Baff Binds to the Tumor Necrosis Factor Receptor-Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the ... Baff Binds to the Tumor Necrosis Factor Receptor-Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the ...
Effective Migration of Antigen-pulsed Dendritic Cells to Lymph Nodes in Melanoma Patients Is Determined by Their Maturation ... Effective Migration of Antigen-pulsed Dendritic Cells to Lymph Nodes in Melanoma Patients Is Determined by Their Maturation ... Effective Migration of Antigen-pulsed Dendritic Cells to Lymph Nodes in Melanoma Patients Is Determined by Their Maturation ... Effective Migration of Antigen-pulsed Dendritic Cells to Lymph Nodes in Melanoma Patients Is Determined by Their Maturation ...
Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T ... Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T ... Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T ...
... referred to as DC maturation, that involve facilitated peptide Ag loading onto MHC class II molecules and their subsequent ... transport to the cell surface. Besides MHC molecules, human DCs … ... dendritic cells (DCs) undergo a series of dynamic cellular events, ... present antigen in immature dendritic cells and traffic independently of MHC class II during dendritic cell maturation J ...
Survivin Essential for the Maturation of Antigen Presenting Cells in Rheumatoid Arthritis Patients. January 2, 2013. • By Lara ... Survivin Essential for the Maturation of Antigen Presenting Cells in Rheumatoid Arthritis Patients ... of survival for bone marrow and spleen hematopoietic cells as they mature and differentiate into antigen presenting cells. ... Studies also have demonstrated that peripheral dendritic cells mature in the spleen and do so in a process that is dependent on ...
B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24). ... B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24). Transgenic Research, 4(3):173-183. ... These mice contain normal numbers of peripheral B-cells and normal serum IgM and IgG titres of ES cell-derived allotype, ... These mice contain normal numbers of peripheral B-cells and normal serum IgM and IgG titres of ES cell-derived allotype, ...
Survivin Essential for the Maturation of Antigen Presenting Cells in Rheumatoid Arthritis Patients. January 2, 2013. • By Lara ... Survivin Essential for the Maturation of Antigen Presenting Cells in Rheumatoid Arthritis Patients ... TNF-α Impairs Regulatory T Cells in Patients with Rheumatoid Arthritis. * Clues Emerge to Bone Health, Destruction in ... TNF-α Impairs Regulatory T Cells in Patients with Rheumatoid Arthritis. *Clues Emerge to Bone Health, Destruction in Rheumatoid ...
Intracellular NOD2 activation promotes maturation and antigen-presenting functions of dendritic cells exposed to Porphyromonas ... Muramyl dipeptide, P. gingivalis-LPS, Dendritic cells, Maturation, Antigen-presenting. Introduction. Dendritic Cells (DCs) are ... Retractde: Intracellular NOD2 activation promotes maturation and antigen-presenting functions of dendritic cells exposed to ... Cell culture. Total bone marrow cells were freshly isolated from tibias, femurs and humerus of the rats. Cells were cultured in ...
... and investigated the possible effect of Hlx gene on maturation of dendritic cell … ... In this study, we established a stable Hlx-over-expressed dendritic cell line (DC2.4/Hlx), ... it appears to drive maturation of Th1 and IFN-γ secretion in cooperation with T-bet. ... Over-expression of Hlx homeobox gene in DC2.4 dendritic cell enhances its maturation and antigen presentation Cell Immunol. Jan ...
... and B-cell-activating factor (BAFF), and one receptor, B-cell maturation antigen (BMCA) involved in B cell development, ... To our knowledge, this is the first report that peripheral blood mononuclear cells produce increased levels of BAFF and APRIL ... This finding provides evidence of systemic regulation of SCI-autoimmunity via APRIL and BAFF mediated activation of B cells ... Recent groundbreaking studies in rodents indicate that B cells are responsible for SCI-induced autoimmunity. This novel ...
A Soluble Form of B Cell Maturation Antigen, a Receptor for the Tumor Necrosis Factor Family Member April, Inhibits Tumor Cell ... A Soluble Form of B Cell Maturation Antigen, a Receptor for the Tumor Necrosis Factor Family Member April, Inhibits Tumor Cell ... BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the ... BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the ...
Dendritic cells (DCs) are the only APCs capable of initiating adaptive immune responses. The initiation of immune responses ... role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation. ... Example: +cell +stem * Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.. Example: +cell - ... "maturation", which transforms DCs into efficient APCs. DC maturation may be initiated by the engagement of different surface ...
Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a ... 1230035-cytolytic-dna-vaccine-encoding-lytic-perforin-augments-the-maturation-of--and-antigen-presentation-by--dendritic-cells- ...
Dendritic cell maturation.. Monocytes from CBMCs were cultured in six-well plates at 106 cells/well in 3 mL dendritic cell (DC ... Naïve antigen-specific T cells are rare within the T-cell repertoire (11). We expected that the range of responses observed ... CD45RO+ memory T cells were not depleted since they were infrequent in CB (Supplementary Fig. 1B). Antigen-responsive cells ( ... However, the ability of antigen-presenting cells to activate naïve T cells was compromised at birth, and CB monocytes had low ...
Thus, high cell concentrations during lipopeptide exposure were detrimental to Mo-DC maturation and function. The duration of ... The lipopeptides contained a single CD4(+) helper T-cell epitopes, one of a number of human leucocyte antigen (HLA)-A2- ... restricted cytotoxic T-cell epitope and the lipid Pam2Cys. To ensure complete maturation of the Mo-DC, we examined (i) the ... The results showed that a high dose of lipopeptide (30 microm) was no more efficient at upregulating maturation markers on Mo- ...
  • B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene. (wikipedia.org)
  • TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). (wikipedia.org)
  • This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. (wikipedia.org)
  • This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. (wikipedia.org)
  • BCMA is a member of the tumor necrosis factor receptor family, expressed on the cell surface of maturing plasma cells and is involved in supporting normal survival of long-lived plasma cells, production of antibodies, and class switching of immunoglobulins. (wikipedia.org)
  • In MM, BCMA promotes the proliferation and survival of MM cells and is associated with the immunosuppression which is the hallmark of MM. The BCMA molecule is the receptor for APRIL (a proliferation-inducing ligand) and BAFF (B-cell activating factor, also known as BLyS).The binding of APRIL and BAFF to the membrane bound form of BCMA stimulates B-cell proliferation and antibody production. (wikipedia.org)
  • B-Cell Maturation Antigen or TNFRSF17 or tumor necrosis factor receptor superfamily member 17, is part of the TNF receptor protein family. (prospecbio.com)
  • This protein is a TNFSF13B/BLyS/BAFF, TNFSF13/APRIL & promotes B-cell survival receptor. (prospecbio.com)
  • We demonstrate that strict "Goldilocks" conditions of affinity for self-lipids by the T-cell antigen receptor expressed on T-cell precursors are necessary for imprinting the proper developmental program toward the invariant NK T-cell lineage. (pnas.org)
  • Our results establish a direct link between the affinity of the T-cell receptor for self-antigens and the proper development of a unique population of lymphocytes that has been implicated in the modulation of a multitude of immune responses in mice and humans. (pnas.org)
  • The self-reactivity of their T-cell antigen receptor (TCR) is thought to contribute to the development of immune regulatory cells, such as invariant NK T cells (iNKT). (pnas.org)
  • These therapies include chimeric antigen receptor T cells, antibody-drug conjugate, and bispecific antibodies. (globenewswire.com)
  • JNJ-68284528 is an autologous chimeric antigen receptor T-cell (CAR-T) therapy that targets B-cell maturation antigen (BCMA). (centerwatch.com)
  • When triggered through the T cell receptor, ligand-experienced cells make IFNγ, whereas ligand-naïve γδ T cells produce IL-17, a major initiator of inflammation. (pubmedcentralcanada.ca)
  • Murine γδ T cells can be divided into two categories based on their receptor diversity, ontogeny and anatomical location. (pubmedcentralcanada.ca)
  • The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor-triggered proliferation. (rupress.org)
  • We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. (rupress.org)
  • references ( 2 )( 3 )( 4 )( 5 )) is expressed in monocytes, macrophages, and dendritic cells ( 2 )( 3 )( 5 ) and has been shown to bind to B cells and increase the proliferation of B cells in combination with an anti-B cell receptor antibody in vitro ( 2 )( 5 ). (rupress.org)
  • In a first-in-human study reported in the Journal of Clinical Oncology , Brudno et al found that chimeric antigen receptor (CAR) autologous T cells targeting B-cell maturation antigen (BCMA) produced responses in patients with poor-prognosis relapsed multiple myeloma. (ascopost.com)
  • This Phase I clinical study will enroll 22 patients to evaluate the safety and efficacy of C-CAR088 (anti-BCMA Chimeric Antigen Receptor T-Cell therapy) in patients with relapsed and/or refractory Multiple Myeloma. (pipelinereview.com)
  • The CBMG pipeline includes preclinical compounds targeting CD20-, CD22- and B-cell maturation antigen (BCMA)-specific CAR-T compounds, and T-cell receptor (TCR) and tumor infiltrating lymphocyte (TIL) technologies. (pipelinereview.com)
  • Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease. (semanticscholar.org)
  • The early activation events that link receptor engagement and DC maturation are not well characterized. (pasteur.fr)
  • T cells at birth are mostly naïve, thereby requiring strong signals through the T-cell receptor and costimulation for priming. (diabetesjournals.org)
  • B cell maturation antigen (BCMA), a plasma cell surface antigen and member of the tumor necrosis factor (TNF) receptor superfamily, is an attractive target for immunotherapy of multiple myeloma due to its high prevalence on malignant plasma cells. (oncotarget.com)
  • The current work details the pre-clinical evaluation of BCMA expression and development of a chimeric antigen receptor (CAR) targeting this antigen using a fully human single chain variable fragment (scFv). (oncotarget.com)
  • SHANGHAI, Aug. 30, 2019 /PRNewswire/ -- CARsgen Therapeutics Inc., a clinical-stage biopharmaceutical company today announced the United States Food and Drug Administration (FDA) has granted orphan drug designation to its investigational CAR-T cell therapy fully human anti-BCMA (B Cell Maturation Antigen) autologous chimeric antigen receptor (CAR) T Cells (ct053) for the treatment of multiple myeloma. (firstwordpharma.com)
  • To assess the potential of antigen targeting to dendritic cells to improve immunity, we incorporated ovalbumin protein into a monoclonal antibody to the DEC-205 receptor, an endocytic receptor that is abundant on these cells in lymphoid tissues. (rupress.org)
  • By better harnessing the immunizing functions of maturing dendritic cells, antibody-mediated antigen targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity, including systemic and mucosal resistance in disease models. (rupress.org)
  • Our strategy was to target antigens to the DEC-205 endocytosis receptor. (rupress.org)
  • Comprehensive quantitation of variables known to influence Tfh differentiation revealed the closest correlation with the strength of T cell receptor (TCR) signaling, leading to PD-1 expression, but not with surface TCR downregulation, irrespective of TCR clonotypic avidity. (frontiersin.org)
  • However, CD4 + T cell differentiation can also be shaped by T cell-intrinsic properties, such as the relative affinity of the T cell receptor (TCR), favoring development of particular subsets ( 6 - 8 ). (frontiersin.org)
  • CCR5, the receptor for chemotactic chemokines MIP1alpha, MIP1beta, and RANTES (CCL3, CCL4, CCL5), exerts major regulatory effects on CD4 + - and CD8 + T cell-mediated immunity. (aacrjournals.org)
  • One molecule that signals to NF-kappaB is CARD11 and the team is investigating the biochemical mechanisms by which CARD11 transduces signals from the T-cell receptor to NF-kappaB. (hopkinsmedicine.org)
  • Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B cell lymphoma/leukemia 10 (Bcl10) During T Cell receptor and Oncogenic Caspase Recruitment Domain-Containing Protein 11 (CARD11) Signaling. (hopkinsmedicine.org)
  • Various microbial components induce the activation of DCs (dendritic cells) through TLR (Toll-like receptor) signaling, which plays a critical role in the generation of protective immune responses [ 1 ]. (hindawi.com)
  • When IgH is able to pair with an IgL light chain, a pre-B cell receptor is formed. (news-medical.net)
  • Then IgM is displayed as a B cell receptor on the immature B cells, and these cells are presented with autoantigens. (news-medical.net)
  • B cells that respond are propagated and undergo a process called hypermutation, where their genes are rearranged to create a B cell receptor that better fits the foreign antigen. (news-medical.net)
  • B cells are activated when they bind to an antigen through a B cell receptor. (news-medical.net)
  • The surface receptor CD21 can enhance B cell activation in complex with CD19 and CD81. (news-medical.net)
  • In that process, the B cell receptor binds an antigen tagged with a fragment of C3 complement protein, and CD21 binds the fragment. (news-medical.net)
  • It then co-ligates with the bound B cell receptor and a signal transduction cascade is initiated that lowers the activation threshold of the cell. (news-medical.net)
  • B cells can also undergo T cell dependent activation, which occurs when a B cell receptor binds a T cell-dependent antigen. (news-medical.net)
  • Early genes, such as mpl coding for the TPO receptor 9 and the GPIIb gene 10 are first expressed in CD34 + cells, but are still expressed in the late stages leading to platelet production. (bloodjournal.org)
  • The T-cell receptor complex with TCR-α and TCR-β chains, CD3 and ζ-chain accessory molecules. (wikipedia.org)
  • The T-cell receptor , or TCR , is a molecule found on the surface of T cells , or T lymphocytes, [1] that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. (wikipedia.org)
  • T cells expressing this receptor are referred to as α:β (or αβ) T cells, though a minority of T cells express an alternate receptor, formed by variable gamma (γ) and delta (δ) chains, referred as γδ T cells. (wikipedia.org)
  • December 21, 2020 (RARITAN, N.J.) - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the initiation of a rolling submission of its Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for ciltacabtagene autoleucel (cilta-cel), an investigational B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of adults with relapsed and/or refractory multiple myeloma. (jnj.com)
  • Negative selection, regulatory T cells, anergy, activation-induced cell death, immune suppression, receptor editing are examples of important steps of immune tolerance. (intechopen.com)
  • This protein and its receptor are both found to be important for B cell development. (cancerindex.org)
  • structure of B cell receptor. (unibo.it)
  • When a cytotoxic cell discovers any infected cell the content of the cytotoxic granules is released by receptor-mediated exocytosis. (wikipedia.org)
  • A Phase 1b/2 study of CAR-T cell therapy directed against BCMA in myeloma patients refractory to a proteasome inhibitor or immunomodulatory drug, and who had received an anti-CD38 antibody showed a 91% overall response rate. (wikipedia.org)
  • Results from CARTITUDE-1: A Phase 1b/2 Study of JNJ-4528, a CAR-T Cell Therapy Directed Against B-Cell Maturation Antigen (BCMA), in Patients with Relapsed and/or Refractory Multiple Myeloma (R/R MM)". Blood. (wikipedia.org)
  • Serum B-cell maturation antigen (sBCMA) is the cleaved form of B-cell maturation antigen (BCMA), found at low levels in the serum of normal patients and generally elevated in patients with multiple myeloma (MM). Changes in sBCMA levels have been found to correlate with a MM patient's clinical status in response to treatment. (wikipedia.org)
  • When BCMA is cleaved from the cell membrane of plasma cells by gamma secretase, a ubiquitous intramembranous protease enzyme, it is solubilized in the serum, where it can accumulate and bind to various targets including BAFF and APRIL. (wikipedia.org)
  • Solubilized BCMA can sequester BAFF, preventing it from signaling B cells, resulting in reduced polyclonal antibody levels in patients with MM. In multiple studies, sBCMA levels have been found to correlate with the severity of myeloma. (wikipedia.org)
  • These drugs aim to inhibit the action of the gamma secretase enzyme, thus both increasing the density of BCMA on the MM cell while at the same time lowering the levels of sBCMA in the blood and allowing anti-BCMA antibodies to more effectively bind to the target cells. (wikipedia.org)
  • B cell maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. (jci.org)
  • CART-BCMA cells were manufactured and expanded in all subjects. (jci.org)
  • Responses and CART-BCMA expansion were associated with CD4/CD8 T cell ratio and frequency of CD45RO-CD27+CD8+ T cells in the premanufacturing leukapheresis product. (jci.org)
  • Soluble BCMA (sBCMA), BAFF, and APRIL concentration, and BCMA expression on MM cells before and after CART-BCMA infusions. (jci.org)
  • C ) Representative examples of BCMA expression on MM cells by flow cytometry. (jci.org)
  • D ) BCMA mean fluorescence intensity (MFI) on MM cells over time in 18 subjects with evaluable serial bone marrow aspirates. (jci.org)
  • To expand the breadth and extent of current multiple myeloma (MM)-specific immunotherapy, we have identified various antigens on CD138 + tumor cells from newly diagnosed MM patients ( n = 616) and confirmed B-cell maturation antigen (BCMA) as a key myeloma-associated antigen. (nature.com)
  • B-cell maturation antigen (BCMA) has emerged as a very selective antigen to be targeted for the treatment of multiple myeloma. (globenewswire.com)
  • The robust pipeline therapies for treatment of multiple myeloma is expected to boost growth of the B-cell maturation Antigen (BCMA) targeted therapies market. (globenewswire.com)
  • Some of the major players involved in the development of B-cell maturation antigen (BCMA) targeted therapies market are Celgene Corporation, GlaxoSmithKline plc, Novartis AG, Juno Therapeutics, Gilead Sciences. (globenewswire.com)
  • Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. (rupress.org)
  • A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. (rupress.org)
  • B cell maturation antigen (BCMA) was first identified as part of a translocation event in a malignant T cell lymphoma patient ( 7 ). (rupress.org)
  • Characterization of human BCMA identified it as a type I membrane protein primarily expressed in immune organs and mature B cell lines ( 7 )( 8 ). (rupress.org)
  • BCMA protein was localized to the Golgi apparatus in the U266 plasmacytoma cell line, which expresses high levels of BCMA ( 9 ). (rupress.org)
  • We characterize the BAFF-BCMA interaction and show that injection of soluble BCMA-Ig fusion protein into mice leads to a dramatic reduction in the total number of B cells in the peripheral immune organs. (rupress.org)
  • Modulation of the peripheral B cell population using BCMA-Ig treatment may be efficacious in treating B cell-mediated disorders. (rupress.org)
  • The current report involves 16 patients who received the highest study dose level of 9 x 10 6 CAR-BCMA T cells/kg. (ascopost.com)
  • Infusion of CAR-BCMA T cells was given after a conditioning regimen of cyclophosphamide and fludarabine. (ascopost.com)
  • At 6 to 9 days postinfusion, CAR-BCMA T cells in the blood were predominantly highly differentiated CD8-positive T cells. (ascopost.com)
  • The investigators concluded, "CAR-BCMA T cells had substantial activity against heavily treated relapsed/refractory [multiple myeloma]. (ascopost.com)
  • this report analyzes the top players in global and United States market, and splits the B-Cell Maturation Antigen(BCMA) Targeted Therapies market by product type and application/end industries. (reportsnreports.com)
  • The global B-Cell Maturation Antigen(BCMA) Targeted Therapies market is valued at XX million USD in 2017 and is expected to reach XX million USD by the end of 2025, growing at a CAGR of XX% between 2017 and 2025. (reportsnreports.com)
  • Any changes from United States might affect the development trend of B-Cell Maturation Antigen(BCMA) Targeted Therapies. (reportsnreports.com)
  • CBMG ) ("CBMG" or the "Company"), a biopharmaceutical firm engaged in the development of immunotherapies for cancer and stem cell therapies for degenerative diseases, today announces the initiation of patient recruitment to support the study of anti-BCMA CAR-T therapy targeting relapsed and refractory Multiple Myeloma in China. (pipelinereview.com)
  • As a drug development company, BCMA is the first of multiple assets that CBMG is advancing amongst our oncology pipeline beyond our collaboration with a global leader in cell therapy," commented Tony (Bizuo) Liu, Chief Executive Officer of the Company. (pipelinereview.com)
  • Deze aangepaste Car-T cel therapie richt zich op een mutatie die veel voorkomt bij multiple myeloma (Kahler) en gebruikten daarvoor het B cell maturation antigen (BCMA) dat de CAR-T cellen moet leiden naar multiple myeloomcellen, samen met een co-stimulerend molecuul bb2121 en noemen dit een anti-BCMA CAR T-celtherapie. (kanker-actueel.nl)
  • The B-Cell Maturation Antigen (BCMA) Targeted Therapies Market report points out national and global business prospects and competitive conditions for b-cell maturation antigen (bcma) targeted therapies. (quincemarketinsights.com)
  • Market size estimation and forecasts were given based on a detailed research methodology tailored to the conditions of the demand for b-cell maturation antigen (bcma) targeted therapies. (quincemarketinsights.com)
  • The b-cell maturation antigen (bcma) targeted therapies market has been segmented by product type (car-t cell, bispecific antibodies, and antibody drug conjugates), by indication (acute lymphoblastic leukemia, and multiple myeloma). (quincemarketinsights.com)
  • Historical background for the demand of b-cell maturation antigen (bcma) targeted therapies has been studied according to organic and inorganic innovations in order to provide accurate estimates of the market size. (quincemarketinsights.com)
  • Primary factors influencing the growth of the demand b-cell maturation antigen (bcma) targeted therapies have also been established with potential gravity. (quincemarketinsights.com)
  • To estimate market size for b-cell maturation antigen (bcma) targeted therapies market on regional and global basis. (quincemarketinsights.com)
  • To identify major segments in b-cell maturation antigen (bcma) targeted therapies market and evaluate their market shares and demand. (quincemarketinsights.com)
  • To provide a competitive scenario for the b-cell maturation antigen (bcma) targeted therapies market with major developments observed by key companies in the historic years. (quincemarketinsights.com)
  • To evaluate key factors governing the dynamics of b-cell maturation antigen (bcma) targeted therapies market with their potential gravity during the forecast period. (quincemarketinsights.com)
  • Market size estimation of the b-cell maturation antigen (bcma) targeted therapies market on a regional and global basis. (quincemarketinsights.com)
  • We demonstrate that BCMA is prevalently, but variably expressed by all MM with expression on 25-100% of malignant plasma cells. (oncotarget.com)
  • Based upon the highly restricted expression of BCMA within normal tissues, we generated a set of novel, fully human scFv binding domains to BCMA by screening a naïve B-cell derived phage display library. (oncotarget.com)
  • FDA orphan designation is an important regulatory milestone in the continued development and commercialization of CT053 anti-BCMA CAR-T cells," said Dr. Zonghai Li, Founder, CEO and CSO of CARsgen. (firstwordpharma.com)
  • B-cell maturation antigen (BCMA) is a protein expressed by normal plasma cells and the malignant plasma cells of multiple myeloma. (careacross.com)
  • BCMA is not expressed by normal cells except for plasma cells and some mature B cells. (careacross.com)
  • We have constructed an anti-BCMA CAR that can specifically recognize BCMA-expressing target cells in vitro and eradicate BCMA-expressing tumors in mice. (careacross.com)
  • Anti-BCMA-CAR-expressing T cells have not been previously tested in humans. (careacross.com)
  • Determine the safety and feasibility of administering T cells expressing an anti- BCMA CAR to patients with MM. (careacross.com)
  • Part 1 of the study consists of screening for BCMA, Lenalidomide assignment and cell collection. (clinicaltrials.gov)
  • Biological: EGFRt/BCMA-41BBz CAR T cell Drug: Cyclophosphamide Drug: Lenalidomide. (clinicaltrials.gov)
  • This is an open-label, dose escalating, nonrandomized, single-center, phase I study of EGFRt/BCMA-41BBz CAR T cells in patients with a diagnosis of MM. Dose escalation will follow a standard 3-by-3 escalation design. (clinicaltrials.gov)
  • Cohorts of 3-6 patients will be infused with escalating doses of EGFRt/BCMA-41BBz CAR T cells to establish the maximum tolerated dose (MTD). (clinicaltrials.gov)
  • The drug, belantamab mafodotin (GSK2857916, GlaxoSmithKline), is an immunoconjugate that targets B-cell maturation antigen (BCMA). (medscape.com)
  • TACI and BCMA stimulation of B cell immune responses. (cancerindex.org)
  • In humans, it has been shown that IC with prostate-specific antigen (PSA) loaded on DCs induce specific CD4 + and CD8 + T cells derived from a healthy donor in vitro ( 13 ), indicating that IC-containing specific antigen proteins loaded on DCs are potentially powerful tools for cancer vaccine. (pnas.org)
  • Here, we extended these observations by showing that the DCs generated with the clinical grade maturation cocktail of MPLA/IFNgamma induce superior tumour antigen-specific CD8(+) CTL responses compared to the cytokine cocktail matured DCs that are currently used in the clinic. (nih.gov)
  • Thus, DC maturation-independent pathways for lipid Ag presentation by CD1 may play a crucial role in host defense, even before DCs are able to induce maximum activation of peptide Ag-specific T cells. (nih.gov)
  • Here, we investigated the potential of PCI as a novel, minimally invasive, and well-tolerated vaccination technology to induce priming of cancer-specific CTL responses to peptide antigens. (frontiersin.org)
  • This leads to activation of CD4+ T helper cells, which induce B cell and antibody-mediated immunity. (frontiersin.org)
  • To induce such responses, it would be valuable to harness the DC system of antigen-presenting cells ( 5 , 6 ). (rupress.org)
  • Third, DCs localize to the T cell areas of lymphoid organs ( 14 , 15 ), where they expand antigen-specific T cells ( 16 - 18 ) and when mature, induce IFN-γ-producing helper and killer T cells ( 19 , 20 ). (rupress.org)
  • Indeed, different classes of pathogens may induce a distinct balance of CD4 + T cell differentiation programmes. (frontiersin.org)
  • Acute viral infections typically induce a CD4 + T cell response that is almost exclusively composed of Tfh and Th1 cells, in approximately equal proportion. (frontiersin.org)
  • Despite decreased avidity, such memory cells afforded protection against infection, but did not induce overt autoimmunity. (umassmed.edu)
  • This study shows that BCG HSP 70 can induce DCs pulsed with antigens maturation and improve their antigen -presenting ability , which may be a useful maturation inducer for dendritic cells . (bvsalud.org)
  • To assess whether soluble E6 and E7 fusion Igs induce effective cellular immune responses, immature dendritic cells (DCs) were treated with these fusion proteins. (elsevier.com)
  • We found that DRibbles could induce a rapid differentiation of monocytes and DC precursor (pre-DC) cells into functional APCs. (nature.com)
  • Our data show that DRibbles could induce strong innate immune responses via multiple pattern recognition receptors, and explain why DRibbles could function as excellent antigen carriers to induce adaptive immune responses to both tumor cells and viruses. (nature.com)
  • Mature DCs are not only characterized as having the function of immunogenic DCs, which induce immunity to foreign antigens, but also characterized by having the phenotypic profile of DCs, which express high levels of costimulatory, adhesion and major histocompatibility complex (MHC) molecules [ 3 ]. (hindawi.com)
  • In addition, in vitro culture in high-glucose medium is sufficient to induce complete maturation of WB-1 cells into functional IPCs. (diabetesjournals.org)
  • In conclusion, GP can induce the maturation of DCs, and does so, in part, by regulating a TLR4-related signaling pathway. (mdpi.com)
  • We further investigated the potential of H. pylori to induce maturation of DCs. (asm.org)
  • Falank C, Fairfield H, Reagan MR. Signaling interplay between bone marrow adipose tissue and multiple myeloma cells. (nature.com)
  • Combination immunotherapy after ASCT for multiple myeloma using MAGE-A3/Poly-ICLC immunizations followed by adoptive transfer of vaccine-primed and costimulated autologous T cells. (nature.com)
  • Shinde P, Fernandes S, Melinkeri S, Kale V, Limaye L. Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy. (nature.com)
  • DCOne as an allogeneic cell-based vaccine for multiple myeloma. (nature.com)
  • More severe cytokine-release syndrome toxicities were observed in patients with a higher percentage of bone marrow multiple myeloma plasma cells. (ascopost.com)
  • Our results should encourage additional development of CAR T-cell therapies for [multiple myeloma]. (ascopost.com)
  • It is estimated that there are 27,800 new cases of Multiple Myeloma, a cancer derived from plasma cells, diagnosed in China each year. (pipelinereview.com)
  • In deze fase I studie met 33 patiënten met recidief of progressie van Multiple Myeloma, werd bb2121 toegediend als een eenmalige infusie van CAR - T-cellen in de doses en veiligheidsstudie. (kanker-actueel.nl)
  • In this study, we have identified serum B-call maturation antigen as a novel biomarker that can monitor and predict outcomes for multiple myeloma patients. (imbcr.org)
  • Compared to healthy donors, patients with multiple myeloma showed elevated serum B-cell maturation antigen levels (P (imbcr.org)
  • Importantly, serum B-cell maturation antigen levels did not show any dependence on renal function and maintained independent significance when tested against other known prognostic markers for multiple myeloma such as age, β2M, hemoglobin, and bone disease. (imbcr.org)
  • These data identify serum B-cell maturation antigen as a new biomarker to manage multiple myeloma patients. (imbcr.org)
  • To test the safety of giving anti-B-Cell Maturation Antigen T cells to people with multiple myeloma. (careacross.com)
  • Multiple myeloma (MM) is a malignancy of plasma cells. (careacross.com)
  • We are committed to innovation in cell therapy and advancing the science of multiple myeloma to improve patients' lives," said Peter Lebowitz, M.D., Ph.D., Global Therapeutic Area Head, Oncology, Janssen Research & Development, LLC. (jnj.com)
  • Today's submission marks Janssen's first cell therapy application, but more importantly, brings cilta-cel one step closer to our goal of making new medical options available to patients with multiple myeloma. (jnj.com)
  • Compared with other APCs such as B cells and macrophages, dendritic cells (DCs) 3 are primarily responsible for priming naive CD4 + Th cells and stimulating the production of proinflammatory cytokines, which in turn determine the phenotype of an ensuing immune response to invading pathogens. (jimmunol.org)
  • Dendritic cells (DC) 3 are potent APCs that play a key role in host immune response against infectious agents and tumors ( 1 , 2 ). (jimmunol.org)
  • Dendritic Cells (DCs) are widely distributed in tissues and organs and they are the body's most efficient Antigen- Presenting Cells (APCs) [ 1 ]. (alliedacademies.org)
  • Dendritic cells (DCs) are the only APCs capable of initiating adaptive immune responses. (pasteur.fr)
  • and 2) undergo a differentiation process, called "maturation", which transforms DCs into efficient APCs. (pasteur.fr)
  • Here, we compare responsiveness and immune competence of circulating T cells and antigen-presenting cells (APCs) during periods of relative protection (birth) and susceptibility (8 months) to islet autoimmunity. (diabetesjournals.org)
  • Here we demonstrate that P-gp functions in IL-12-dependent monocyte differentiation into dendritic cell (DC) lineages during APC maturation, thereby regulating the capacity of myeloid-derived APCs to elicit alloimmune Th1 responses. (meta.org)
  • APCs differentiated in the presence of P-gp blockade stimulated alloimmune T-cell proliferation significantly less than controls and this effect was associated with 97% inhibition of Th1 IFN-gamma production, but preserved Th2 IL-5 secretion. (meta.org)
  • We show that PCI effectively promotes delivery of peptide antigens to the cytosol of antigen-presenting cells (APCs) in vitro . (frontiersin.org)
  • Similar to many pathogens, these vaccines are endocytosed by antigen-presenting cells (APCs) for lysosomal degradation and subsequent entry into the MHC class II antigen presentation pathway. (frontiersin.org)
  • In this report, we investigated the underlining mechanisms by which DRibbles induced T-cell activation, particularly how DRibbles activated antigen-presenting cells (APCs). (nature.com)
  • In contrast to the well-established inhibitory effect of autophagy on the inflammasome activation of APCs, our study demonstrates that isolated autophagosomes (DRibbles) from antigen donor cells activate inflammasomes by providing first and second signals required for IL-1 β production by PMBC. (nature.com)
  • Dendritic cells (DCs) are the most powerful antigen presenting cells (APCs) in the immune system. (springer.com)
  • Dendritic cells (DCs) are professional antigen presenting cells (APCs) that play a pivotal role in the initiation of immune responses due to their capacity for antigen presentation and activation of naive cytotoxic T lymphocytes (CTLs) [ 1 ]. (springer.com)
  • In contrast to non-professional APCs, in which early generation and presentation of CTL epitopes is required to allow rapid elimination of the infected cells, the situation for DCs is different. (springer.com)
  • DCs are generally viewed as the most potent professional APCs (antigen presenting cells). (hindawi.com)
  • Formulations comprising combinations of APCs and tumor cells and APCs and virally infected cells are disclosed. (freepatentsonline.com)
  • Furthermore, the CTLs proved to kill tumour cells expressing endogenous tumour antigen in vitro. (nih.gov)
  • However, splenic B cells from transgenic or control mice were found to proliferate at the same rate ( 6 ), suggesting that BAFF, in addition to its ability to costimulate B cell proliferation in vitro, may have alternative functions. (rupress.org)
  • Functional assay for DC2.4/Hlx showed that over-expressed Hlx increased the expression level of interleukin-12 in the supernatant and decreased DC endocytosis when cells were incubated in vitro. (nih.gov)
  • In vitro studies indicated that CCR5 might also have migration-independent effects on T-cell activation, by participating in the costimulation of CD4 + lymphocytes in cooperation with the TCR ( 8-10 ). (aacrjournals.org)
  • We reveal that PO increases T-cell proliferation in vitro without negative effects on any activation marker. (medworm.com)
  • To explore whether TLR2/TLR4 could be involved in the maturation of dendritic cells and polarization of CD4 + T cells induced by dendritic cells stimulated with MBP and BCG, in vitro and in vivo experiments using TLR2 −/− or TLR4 −/− mice were employed. (hindawi.com)
  • We previously demonstrated that hepatic stem cells could be induced in vitro to transdifferentiate into insulin-producing pancreatic endocrine-like cells ( 3 ). (diabetesjournals.org)
  • To establish an in vitro system to study the molecular mechanism of selective liver to endocrine pancreas transdifferentiation, we generated a stably transfected rat hepatic cell line (WB-1) that overexpresses an activated form of Pdx1 (Pdx1-VP16) along with a reporter gene, RIP-eGFP , to monitor insulin gene expression. (diabetesjournals.org)
  • In this study, we investigated the profile of gene expression induced by Pdx1-VP16-mediated transdifferentiation of WB-1 cells in vitro and during in vivo cell transplantation. (diabetesjournals.org)
  • However, these precursor cells require either in vivo hyperglycemia or in vitro long-term high-glucose culture to become fully functional pancreatic endocrine cells. (diabetesjournals.org)
  • This study defined the progressive expression of the GPIb-V-IX complex during in vitro MK maturation and compared it to that of GPIIb, an early MK marker. (bloodjournal.org)
  • For example, patients with partial DGS rarely lack T-cell function as measured by in vitro T-cell proliferation to nonspecific mitogens. (medscape.com)
  • Human dendritic cells (DC) can now be generated in vitro in large numbers by culturing CD34 + hematopoietic progenitors in presence of GM-CSF+TNFet for 12 d. (psu.edu)
  • 14. The formulation of claim 13, wherein said dendritic cells are selected from the group consisting of cutaneous epidermal Langerhans cells, dermal dendritic cells, lymph node dendritic cells, spleen dendritic cells and dendritic cells derived through in vitro culture of precursors. (freepatentsonline.com)
  • Probiotic metabolites from Bacillus coagulans Ganeden BC30™ support maturation of antigen-presenting cells in vitro. (aibmr.com)
  • The murine differentiation marker heat stable antigen (HSA) is a GPI-anchored surface glycoprotein showing strong expression on immature B- and T-lymphocytes and gradually reduced expression during maturation. (uzh.ch)
  • Immature DCs uptake antigens and mature DCs present antigens to naive T-lymphocytes, then stimulate naive T cells to differentiate to be effector T cells [ 2 ], thus, DCs are important key mediators between innate and acquired immune responses [ 3 ]. (alliedacademies.org)
  • For many diseases that lead to high mortality and morbidity, such as AIDS and malaria, it is likely that vaccines will need to elicit strong T cell-mediated immunity composed of IFN-γ secreting CD4 + helper and CD8 + cytolytic T lymphocytes (for reviews see references 1 - 4 ). (rupress.org)
  • Second, DCs become potent stimulators of immunity after undergoing a complex differentiation or maturation program in response to a panel of stimuli including microbial ligands for toll-like receptors ( 9 , 10 ), innate lymphocytes ( 11 , 12 ), and CD40 ligation ( 13 ). (rupress.org)
  • The immunological defect is caused by deletions or mutations of Bruton's tyrosine kinase gene (Btk ), whose product is critically involved in the maturation of pre-B lymphocytes into mature B cells. (torvergata.it)
  • Btk is expressed not only in B lymphocytes but also in cells of the myeloid lineage, including dendritic cells (DC). (torvergata.it)
  • Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes. (duke.edu)
  • T cells are fairly uncommon in the lamina propria but are even more enriched in the tiny and huge intestinal intraepithelial lymphocytes, which primarily contain TCR and TCRCD8 cells (10, 11). (ourworldisblue.com)
  • For full comprehension of the role of CCR5 in T cell-mediated responses, it is particularly important to determine whether its expression in CD4 + lymphocytes is necessary for optimal dendritic cell (DC) activation and antigen crosspresentation. (aacrjournals.org)
  • CD36, and cross-present antigens to cytotoxic T lymphocytes. (bio.net)
  • Lymphoid tissues contain lymphocytes , and also contain other types of cells for support. (wikipedia.org)
  • The primary or central lymphoid organs generate lymphocytes from immature progenitor cells . (wikipedia.org)
  • Mature lymphocytes recirculate between the blood and the peripheral lymphoid organs until they encounter their specific antigen. (wikipedia.org)
  • Secondary lymphoid tissue provides the environment for the foreign or altered native molecules (antigens) to interact with the lymphocytes. (wikipedia.org)
  • The nomenclature for T lymphocytes is based on the role of the thymus in the differentiation and maturation of T lymphocytes. (medscape.com)
  • This bacterial colonization leads to a cellular infiltrate of polymorphonuclear leukocytes, an acute immune response, followed by the migration of macrophages, lymphocytes, and plasma cells in the gastric mucosa, resulting in chronic gastritis. (asm.org)
  • Peripheral tolerance occurs at mature lymphocytes encounter self-antigens in peripheral tissues. (intechopen.com)
  • The enhanced cross-presentation reflects, at least in part, the efficient uptake of IC-bound antigen by means of plasma membrane Fcγ receptors ( 5 , 7 , 8 ). (pnas.org)
  • By using IC-loaded DCs, ovalbumin (OVA)-specific CD4 + and CD8 + T cells have been successfully induced in mice ( 8 ), suggesting that effective cross-presentation also occurs in vivo . (pnas.org)
  • To develop a vaccine strategy by using IC, it is essential to understand the mechanism of antigen transport from the membrane to the cytosol by means of the cross-presentation pathway in DCs, which remains to be elucidated. (pnas.org)
  • In the present follow-up work, we investigated whether maturation may be an important factor enabling cross-presentation in DCs. (pnas.org)
  • Besides MHC molecules, human DCs prominently express molecules of the CD1 family (CD1a, -b, -c, and -d) and mediate CD1-dependent presentation of lipid and glycolipid Ags to T cells, but the impact of DC maturation upon CD1 trafficking and Ag presentation is unknown. (nih.gov)
  • In contrast, antigen presentation and expression of these molecules had reached competent adult levels by the high incidence age of 8 months. (diabetesjournals.org)
  • We propose that temporal changes in islet autoimmunity seroconversion in infants are a consequence of the changing balance between homeostatic drive and antigen presentation competence. (diabetesjournals.org)
  • Antigen (Ag) crosspresentation by dendritic cells (DCs) involves the presentation of internalized Ags on MHC class I molecules to initiate CD8+ T cell-mediated immunity in response to certain pathogens and tumor cells. (pasteur.fr)
  • This requires cytosolic antigens that feed into the MHC class I presentation pathway, which is not efficiently achieved with most current vaccination technologies. (frontiersin.org)
  • This resulted in a 30-fold increase in MHC class I/peptide complex formation and surface presentation, and a subsequent 30- to 100-fold more efficient activation of antigen-specific CTLs compared to using the peptide alone. (frontiersin.org)
  • It is expressed at high levels on lymphoid tissue DCs ( 21 - 23 ) and greatly enhances the efficiency of antigen presentation ( 24 , 25 ). (rupress.org)
  • Along with their crucial function in the cellular immune response, namely the degradation of microbes, they play a role in antigen presentation and adaptive immunity. (mdpi.com)
  • The use of dendritic cells transfected with RNA encoding tumor antigen offers the prospect of antigen-specific immunization without requiring prior knowledge of the immunogenic epitope or restricting allele, since epitopes from the translated protein are processed by the endogenous antigen-presentation machinery. (duke.edu)
  • Such RNA-transfected mature DC exhibited a prolonged duration of presentation of immunogenic epitopes compared to peptide-pulsed DC, induced greater frequencies of tumor antigen-specific CTL, and generated a CTL population that exhibited higher target avidity and increased tumor lytic capacity. (duke.edu)
  • Immune responses are multistep processes that entail antigen presentation, optimal triggering of specific T cells, and localization of immune effectors to appropriate sites. (aacrjournals.org)
  • However, tumor cells have developed a variety of resistance mechanisms to suppress the MHC class I antigen presentation, and thereby impair the cytotoxicity of CD8+ T cells. (medworm.com)
  • So, it is hypothesized that DALIS can function as antigen depots allowing DCs to coordinate maturation and antigen presentation during their migration to the lymph nodes. (springer.com)
  • The formation of DALIS is inhibited in these cells which can be expected to influence antigen processing and presentation. (springer.com)
  • So, it was hypothesized that DALIS can function as antigen depots which delay the antigen presentation in DCs until a proper maturation status has been achieved which ensures efficient activation of T cells. (springer.com)
  • Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells. (wikipedia.org)
  • Recent studies have investigated possible impairment of antigen presentation. (asm.org)
  • VacA, an H. pylori virulence factor, was reported to interfere with proteolytic processing of tetanus toxoid and was shown to inhibit the Ii-dependent pathway of antigen presentation ( 38 ). (asm.org)
  • We hypothesized that this modest activity was due to the use of immature dendritic cells with lower levels of costimulatory and adhesion molecules necessary for T-cell activation ( 4 - 7 ), poor expression and presentation of the tumor epitopes by the dendritic cells loaded with mRNA (which may be rapidly degraded on uptake by dendritic cells), and lack of HLA class II peptides needed to activate T-cell help. (aacrjournals.org)
  • The effect was found to be highly dependent on the dose of the PCI treatment, where optimal doses promoted maturation of immature dendritic cells, thus also providing an adjuvant effect. (frontiersin.org)
  • Controls consisted of immature dendritic cells loaded with tetanus toxoid and a HLA A2-restricted peptide derived from cytomegalovirus pp65 protein. (aacrjournals.org)
  • The 15 kDa form is also able to act as a chemoattractant for different cells, such as NK cells, cytotoxic T cells, helper T cells, and in higher concentrations, immature dendritic cells. (wikipedia.org)
  • We compared monocyte-derived dendritic cells and transforming growth factor-β1-induced Langerhans-like cells (LCs) for their capacity to cross-present exogenous NY-ESO-1 protein/antibody immune complexes to an NY-ESO-1-specific CD8 + T cell clone. (pnas.org)
  • Recently, the expression of an immunoglobulin-like transmembrane protein, encoded by Skint1 (selection and upkeep of intraepithelial T cells 1) , on fetal thymic stromal cells was identified as necessary for the positive selection of the DETCs [ 8 ]. (pubmedcentralcanada.ca)
  • Therefore, protein tyrosine phosphorylation by Syk represents a novel pathway for the induction of DC maturation. (pasteur.fr)
  • Patients must have measurable MM defined as a serum M-protein greater than or equal to 1 g/dL or a urine M-protein greater than or equal to 200 mg/24 hours or an involved serum free light chain (FLC) level greater than or equal to 10 mg/dL (provided FLC ratio is abnormal) or a biopsy-proven plasmacytoma or greater than 30% bone marrow plasma cells. (careacross.com)
  • We will show that a single low s.c. dose of a protein-based vaccine is able to charge DCs with antigen systemically and for long periods, particularly on MHC class I products. (rupress.org)
  • Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate. (nih.gov)
  • MBP and BCG elevated CD80, CD86 and MHC class II expressed on dendritic cells and increased IL-12 protein, induced DC maturation, and indirectly promoted Th1 activation. (hindawi.com)
  • while treatment with a recombinant intracellular protein - FhPGK, had no impact on cell survival. (springer.com)
  • However, multiple studies ( 10 , 12 - 15 , 18 , 22 , 29 ) have shown that broadly directed and/or dominant HIV-specific CD8 T-cell responses against the Gag protein, as measured by IFN-γ enzyme-linked immunospot (ELISPOT) assay, are associated with lower viremia in chronic HIV-1 infection. (pubmedcentralcanada.ca)
  • Indeed, more broadly directed CD8 T-cell responses directed to the Env protein have been associated with elevated viremia ( 15 ). (pubmedcentralcanada.ca)
  • One potential explanation for enhanced antiviral pressure by Gag-specific but not other virus-specific CD8 T-cell responses may be differences in the fitness cost associated with escape mutations within the highly conserved Gag protein compared to that of other viral proteins ( 5 , 23 , 27 ). (pubmedcentralcanada.ca)
  • These findings provide insight into protein-specific factors that are associated with variability in the magnitude of antibody responses to natural P. falciparum infection-data that could inform vaccine strategies to optimize antibody-mediated immunity as well as the selection of antigens for sero-diagnostic purposes. (ajtmh.org)
  • To do so, each new B cell comes equipped with its own highly specialized weapon, a unique antibody protein that selectively binds to specific parts of the antigen. (eurekalert.org)
  • Immature DCs derived from CD34 � HPCs migrate most vigorously in response to macrophage inflammatory protein (MIP)-3�, but also to MIP-1 � and RANTES (regulated on activation, normal T cell expressed and secreted). (psu.edu)
  • Because of the crucial role of dendritic cells in adaptive immunity and their potent activity in animal tumor models, numerous pilot studies have evaluated immunotherapy with dendritic cells loaded with antigen in the form of peptide, protein, DNA, mRNA, tumor lysates, tumor fusions, and viral vectors ( 1 ). (aacrjournals.org)
  • Granulysin is expressed in killer cells, such as cytotoxic T cells and Natural Killer (NK) cells, which hold the cytotoxic granules this protein is contained in. (wikipedia.org)
  • The 9 kDa form functions as a pore-forming protein, as it is able to permeabilize cell membranes. (wikipedia.org)
  • This protein is also far more effective in targeting bacterial membranes than mammalian membranes, though it can target many different cell types, such as those from fungi and parasites. (wikipedia.org)
  • Although several cytokines, such as IL-12 in synergy with IL-15 or IL-18, may result in Th1 cell development ( 3 , 4 ), IFN-γ is the central effector cytokine mediating protective immunity to blood-stage malaria infection ( 5 ). (jimmunol.org)
  • Furthermore, regardless of antigen experience, γδ T cells can be triggered to produce cytokines without requirement for antigen specific priming. (pubmedcentralcanada.ca)
  • The ability of MDP to promote DCs secreting cytokines was far below P. gingivalis- LPS but MDP could promote the functions of Th2 cell-promoting DCs induced by P. gingivalis -LPS. (alliedacademies.org)
  • Priming DCs with microbial compounds up-regulates the expression of costimulatory molecules and the production of proinflammatory cytokines, which drives T-helper (Th) cells to differentiate to Th1 or Th2 cells [ 4 ]. (alliedacademies.org)
  • Th17 cells with both anti-microbial and pro-inflammatory properties are enriched in the intestinal lamina proprial layer and produce signature cytokines IL-17 and IL-22. (ourworldisblue.com)
  • However, Th17 cells have also been considered to be pathogenic in autoimmune diseases, such as human inflammatory bowel disease (IBD), by secreting pro-inflammatory cytokines such as IL-17, IL-17F, and IL-22 that contribute to tissue inflammation and damage (15C17). (ourworldisblue.com)
  • Interestingly, IL-17 has also been reported to be protective in CD45RBhi T cell transfer colitis by inhibiting Th1 cytokines (e.g. (ourworldisblue.com)
  • During this time the cells undergo changes in their expression levels of surface molecules and they start to secrete proinflammatory cytokines. (springer.com)
  • In addition to the secretion of IFN-γ, CD8 T cells exhibit a spectrum of additional antiviral functions, including cytolysis, cell proliferation, and production of cytokines and chemokines. (pubmedcentralcanada.ca)
  • The capacity of CD8 T cells to secrete multiple cytokines following stimulation with HIV peptides is also associated with long-term nonprogressive infection, although subsequent studies have argued that polyfunctionality may simply correlate with reduced antigen stimulation rather than being a direct mediator of viral control ( 4 , 19 , 28 , 34 ). (pubmedcentralcanada.ca)
  • Human cord blood CD34 + progenitor cells were cultured in the presence of cytokines inducing megakaryocytic differentiation. (bloodjournal.org)
  • Proliferation and maturation of MK precursors are controlled by several pleiotropic cytokines. (bloodjournal.org)
  • Megakaryocytic differentiation is accompanied by changes in cell morphology, notably an increase in size and the appearance of demarcation membranes, and by the sequential expression of a number of genes coding for specific cell surface markers, cytokines, and cytokine receptors. (bloodjournal.org)
  • Many current vaccination protocols consist of recombinant molecules or subunits of pathogens delivered in combination with an immunological adjuvant, and protect mainly by induction of antibody-mediated humoral immune responses toward extracellular antigens ( 1 ). (frontiersin.org)
  • Simultaneously, we injected agonistic α-CD40 antibody to mature the dendritic cells. (rupress.org)
  • We found that a single low dose of antibody-conjugated ovalbumin initiated immunity from the naive CD4 + and CD8 + T cell repertoire. (rupress.org)
  • NO:7 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:9, wherein said humanized antibody binds prostate stem cell antigen (PSCA), and wherein administration of said humanized antibody to a subject diagnosed with prostate cancer decreases tumor growth to a greater extent than treatment with the murine 1G8 monoclonal antibody. (google.co.uk)
  • Thus, T-cell to B-cell communication is defective, with partial defects in antibody production and increased incidence of atopy and autoimmune disorders. (medscape.com)
  • Inadequate antibody responses directed against bacterial polysaccharide antigens cause an increased risk for sinopulmonary infections caused by encapsulated organisms. (medscape.com)
  • Described online this week in the journal Proceedings of the National Academy of Sciences ( PNAS ), the findings add a surprising new dimension to the understanding of antibody repertoires - each individual's complement of millions of B cells -- and the potential for shaping these repertoires to better fight disease. (eurekalert.org)
  • We were surprised and excited to find that B cell survival could be influenced by a non-antigen-binding region of the antibody, specifically the 'elbow' region that connects the antigen-binding regions to the signaling domain. (eurekalert.org)
  • Each new B cell makes its own unique antibody by mixing and matching from a set of a few hundred genes, taking one each from subsets called V, D and J. The most diverse part of an antibody is the region where the three genes come together, a stretch called the third complementarity-determining region, or CDR3. (eurekalert.org)
  • We initially wanted to ask how selection on CDR3 changed antibody repertoires during B-cell maturation," says Arnaout. (eurekalert.org)
  • Pathogenic autoantibodies can protect or cause diseases via neutralization of self-antigens, opsonization, antibody-dependent cellular cytotoxicity, activation of the complement system, pro-inflammatory and anti-inflammatory effect. (intechopen.com)
  • 4. The immunostimulatory regimen of claim 1 wherein the an agonistic CD40L polypeptide or CD40 agonistic antibody or antibody fragment, type 1 interferon and viral antigen are administered as discrete polypeptides. (google.com.au)
  • 8. The immunostimulatory regimen of claim 2 wherein the an agonistic CD40L polypeptide or CD40 agonistic antibody or antibody fragment, type 1 interferon and viral antigen are administered as discrete compounds in combination. (google.com.au)
  • B-cell maturation antigen, a proliferation-inducing ligand, and B-cell activating factor are candidate mediators of spinal cord injury-induced autoimmunity. (semanticscholar.org)
  • INTRODUCTION: The tumour necrosis factor (TNF) family ligands BAFF (B-cell activating factor of TNF family) and APRIL (a proliferation-inducing ligand) are essential for B-cell survival and function. (biomedsearch.com)
  • In peripheral tissues, DCs internalize antigens and then migrate to lymphoid organs where they process the sequestered antigens into peptides, load them onto MHC molecules, and finally present peptide/MHC complexes on their cell surface ( 1 , 2 ). (pnas.org)
  • Upon exposure to Ag and inflammatory stimuli, dendritic cells (DCs) undergo a series of dynamic cellular events, referred to as DC maturation, that involve facilitated peptide Ag loading onto MHC class II molecules and their subsequent transport to the cell surface. (nih.gov)
  • Using monocyte-derived immature DCs and those stimulated with TNF-alpha for maturation, we observed that none of the CD1 isoforms underwent changes in intracellular trafficking that mimicked MHC class II molecules during DC maturation. (nih.gov)
  • In addition, unlike MHC class II, DC maturation-associated transport from lysosomes to the plasma membrane was not readily detected for CD1b despite the fact that both molecules were prominently expressed in the same MIIC lysosomal compartments before maturation. (nih.gov)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • However, after being activated by BCG HSP 70, the DCs pulsed with antigens could keep their special markers and the expression levels of CD54, CD83, CD86 molecules increased too. (bvsalud.org)
  • In conclusion, TLR2 and TLR4 play an important role in the upregulation of costimulatory molecules and MHC class II molecules on dendritic cells and the activation of Th1 cells induced by stimulation with MBP and BCG. (hindawi.com)
  • Treatment of DCs with GP resulted in the enhanced expression of the cell surface molecules CD80, CD86 and MHC I-A/I-E. GP also increased the production of IL-12 p70 by DCs in a time-dependent manner. (mdpi.com)
  • Fluorescence-activated cell sorting analysis of cell surface expression of maturation marker molecules such as CD80, CD83, CD86, and HLA-DR revealed equal upregulation after stimulation with H. pylori or LPS. (asm.org)
  • To determine the safety and immunologic and clinical efficacy of a dendritic cell vaccine modified to hyperexpress costimulatory molecules and tumor antigen. (aacrjournals.org)
  • In this phase I study, we administered one or two cycles of four triweekly s.c./intradermal injections of ex vivo generated dendritic cells modified with a recombinant fowlpox vector encoding carcinoembryonic antigen (CEA) and a triad of costimulatory molecules [rF-CEA(6D)-TRICOM]. (aacrjournals.org)
  • To overcome these limitations, we have been studying strategies for genetic modification of dendritic cells with viral vectors encoding full length tumor antigens and costimulatory molecules. (aacrjournals.org)
  • Dendritic cell-based immunity and vaccination against hepatitis C virus infection. (semanticscholar.org)
  • The prevention and treatment of prevalent infectious diseases and tumors should benefit from improvements in the induction of antigen-specific T cell immunity. (rupress.org)
  • This was associated with stronger CD8 + T cell-mediated immunity relative to other forms of antigen delivery, even when the latter was given at a thousand times higher doses. (rupress.org)
  • In parallel, naive mice develop immunity, including CD8 + T cell-mediated immunity, which is considerably enhanced relative to prior methods of immunization with 1,000-fold higher doses of antigen and is associated with stronger protection in anti-viral and anti-tumor models. (rupress.org)
  • The combined effect of such T cell-extrinsic and T cell-intrinsic factors can result in considerable diversity of functional responses, allowing adaptive immunity to modify its response according to the nature of the antigenic stimulus. (frontiersin.org)
  • A subset of innate lymphoid cells (ILCs) expressing RORt is vital for gut immunity. (ourworldisblue.com)
  • Promotes B-cell survival and plays a role in the regulation of humoral immunity. (genecards.org)
  • Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. (pubmedcentralcanada.ca)
  • Although several studies investigated the interaction between H. pylori and the innate immunity ( 9 , 17 , 21 , 24 , 35 , 56 ), little is known about the influence of H. pylori on dendritic cells (DCs), especially in the human immune system ( 14 , 59 ). (asm.org)
  • Dendritic cells (DC) are the major antigen-presenting cells bridging innate and adaptive immunity, a function they perform by converting quiescent DC to active, mature DC with the capacity to activate naïve T cells. (sigmaaldrich.com)
  • Mechanisms of antigen recognition of Innate Immunity (TLR, RIG, NLR and inflammasome). (unibo.it)
  • Functions in the Immune response: cell-mediated immunity. (unibo.it)
  • A Phase IIb trial in China for Rejoin® autologous Human Adipose-derived Mesenchymal Progenitor Cell (haMPC) for the treatment of Knee Osteoarthritis (KOA) as well as a Phase I trial in China for AlloJoin™ (CBMG's "Off-the-Shelf" haMPC) for the treatment of KOA are ongoing. (pipelinereview.com)
  • Human dendritic cells pulsed with specific lipopeptides stimulate autologous antigen-specific T cells without the addition of exogenous maturation factors. (semanticscholar.org)
  • Autologous T cells genetically modified to express CARs targeting the B-cell antigen CD19 have caused complete remissions in a small number of patients with leukemia or lymphoma. (careacross.com)
  • Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined the influence of Gag specificity on the ability of unstimulated CD8 T cells from chronically infected persons to inhibit virus replication in autologous CD4 T cells. (pubmedcentralcanada.ca)
  • 1 For unicellular organisms, the survival is largely dependent on the autophagy pathway as a cell-intrinsic defense mechanism to acquire nutrients by recycling damaged proteins and other biomolecules. (nature.com)
  • Multipotent hematopoietic progenitors of B cells migrate into the fetal liver and bone marrow, and take up residence in new environments to commence development along the B lineage pathway. (news-medical.net)
  • This suggested that caspases may be associated with a p53-mediated Bax-dependent cell death pathway. (jneurosci.org)
  • In this study we quantified CD8(+) and CD4(+) T cells in T lymphocytopenic BB rats as compared with control rats at given stages along the maturational pathway from immature thymocytes to mature peripheral T cells. (rug.nl)
  • Consistent with their seminal role in detecting infection, both mouse bone marrow-derived and splenic CD11c + dendritic cells (DCs) exhibited higher levels of uptake of Plasmodium chabaudi -parasitized RBCs (pRBCs) than of noninfected RBCs (nRBCs) as determined by our newly developed flow cytometric technique using the dye CFSE to label RBCs before coculture with DCs. (jimmunol.org)
  • Thus, in the current study, the authors were able to treat mice with an Flt3 inhibitor and thereby decrease survivin expression in the bone marrow and in the dendritic cell population in the spleen. (the-rheumatologist.org)
  • The authors concluded that survivin expression is a downstream event of Flt3L signaling and that it serves as an essential mechanism of survival for bone marrow and spleen hematopoietic cells as they mature and differentiate into antigen presenting cells. (the-rheumatologist.org)
  • However, a reduction in immature B-cells in the bone marrow and an altered degree of bone marrow and blood chimaerism suggest that HSA expression influences the maturation of B-cells. (uzh.ch)
  • MM derives from the clonal expansion of malignant bone marrow plasma cells (PC), and is associated with clinical complications including hypercalcemia, renal insufficiency, symptomatic anemia, destructive lytic bone lesions, and increased susceptibility to infection. (oncotarget.com)
  • Among patients with non secretory disease, serum B-cell maturation antigen levels correlated with bone marrow plasma cell levels and PET scan findings. (imbcr.org)
  • B cells originate in fetal liver and bone marrow in mammals, developing from hematopoietic stem cells (HSCs). (news-medical.net)
  • Those with high-affinity autoreactive B cell receptors are deleted, and those with low-affinity autoreactive B cell receptors leave the bone marrow and enter peripheral blood pools, particularly in the lung and gut lymphoid tissues. (news-medical.net)
  • More than 85% of new, immature B cells die in the bone marrow due to autoantigen recognition. (news-medical.net)
  • The bone marrow microenvironment crucially shapes the development of B cells. (news-medical.net)
  • Bone marrow stromal cells create distinct niches that support B cell development.Factors required for B cell development are thought to be produced by cells of the bone marrow, and are delivered to the precursor B cells at an appropriate stage of development. (news-medical.net)
  • Reticular cells, surrounding bone marrow sinuses, have been shown to be associated with B cells, and may play a role in forming niche environments for B cell development. (news-medical.net)
  • Bone marrow is responsible for both the creation of T cells and the production and maturation of B cells . (wikipedia.org)
  • From the bone marrow, B cells immediately join the circulatory system and travel to secondary lymphoid organs in search of pathogens. (wikipedia.org)
  • T cells, on the other hand, travel from the bone marrow to the thymus, where they develop further. (wikipedia.org)
  • Secondary organs - sites where B and T cells induced to function (lymph nodes, spleen, bone marrow, Peyer's patches). (brainscape.com)
  • Mononuclear cells (MNCs) were isolated from murine bone marrow and induced to become DCs by culturing with GM-CSF and IL-4. (mdpi.com)
  • Conventional clinical management for absent T-cell function consists of immune reconstitution using stem cell or bone marrow transplantation. (medscape.com)
  • Here, we demonstrate that myeloid cell-specific genetic deletion of PTP1B (LysM PTP1B) leads to defects in lipopolysaccharide-driven bone marrow-derived DC (BMDC) activation associated with increased levels of phosphorylated Stat3. (sigmaaldrich.com)
  • The uptake of pRBCs by splenic CD11c + DCs was significantly enhanced after infection in vivo and was associated with the induction of DC maturation, IL-12 production, and stimulation of CD4 + T cell proliferation and IFN-γ production. (jimmunol.org)
  • however, ex vivo maturation of DC derived from patients with cancer in a polarizing cytokine mix restores normal expression of APM components and Ag-processing capabilities. (jimmunol.org)
  • Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T cell immune responses. (harvard.edu)
  • The effect of PCI was confirmed in vivo by the successful induction of antigen-specific CTL responses to cancer antigens in C57BL/6 mice following intradermal peptide vaccination using PCI technology. (frontiersin.org)
  • The interaction of endosomes and lysosomes with E. coli phagosomes observed in Drosophila hemocytes was consistent with that previously described for phagosome maturation in human ex vivo macrophages. (mdpi.com)
  • Immunization of ovalbumin (OVA)-expressing transgenic mice with recombinant viruses expressing OVA-peptide variants induced self-reactive T cells in vivo that matured into memory T cells able to respond to secondary infection. (umassmed.edu)
  • Moreover, to our knowledge, no studies have addressed the precise role of CCR5 in in vivo CD4 + T-cell function. (aacrjournals.org)
  • Most infection studies with L. monocytogenes have been performed with mouse cells or an in vivo mouse model of infection. (asm.org)
  • These results suggest that DCs selectively phagocytose pRBCs and present pRBC-derived Ags to CD4 + T cells, thereby promoting development of protective Th1-dependent immune responses to blood-stage malaria infection. (jimmunol.org)
  • Immune effector mechanisms that mediate control of parasitemia involve macrophages, NK cells, CD4 + T cells, and IFN-γ production, while B cells and Th1-dependent Ab responses are required for elimination and resolution of the chronic stage of infection (reviewed in Ref. 2 ). (jimmunol.org)
  • Spleen cells from young male F1 mice (4- to 6-wk old) show lower mitogenic responses to lipopolysaccharide, a lower frequency of sheep erythrocytes (SRBC)-reactive B-cell precursors, and a lower percentage of Ig-bearing cells than age-matched female F1 mice. (rupress.org)
  • We found naïve proinsulin- and GAD65-responsive T cells in cord blood (CB) of healthy newborns, with highest responses observed in children with type 1 diabetes-susceptible HLA-DRB1/DQB1 genotypes. (diabetesjournals.org)
  • These cells are professional antigen presenting cells (APC) that play a fundamental role in the induction and regulation of T-cell responses. (torvergata.it)
  • In conclusion, these data indicate that Btk defect is not involved in DC differentiation and maturation, and that XLA-DC can act as fully competent antigen presenting cells in T cell-mediated immune responses. (torvergata.it)
  • This is the first comprehensive study to show the molecular basis of how soluble HPV 16 E6 or E7 fusion Igs induces Th1 responses through the maturation of DCs. (elsevier.com)
  • Our results indicate that CCR5 boosts T-cell responses to tumors by modulating helper-dependent CD8 + T-cell activation. (aacrjournals.org)
  • CCR5 is a central element in modulating helper-dependent CD8 + T-cell responses, by guiding these cells to productive CD4 + /antigen-presenting cell (APC) complexes ( 6 ). (aacrjournals.org)
  • Autophagosomes derived from tumor cells, also referred to as defective ribosomal products in blebs (DRibbles), have been previously shown to stimulate potent T-cell responses and mediate tumor regression when used as therapeutic cancer vaccines in multiple preclinical cancer models. (nature.com)
  • For multicellular organisms, autophagy serves an important role as a cell-intrinsic defense mechanism and a key regulator of inflammatory responses. (nature.com)
  • There is growing evidence that microRNA-155 (miR155) modulates gene expression in various cell types of the immune system and is a prominent player in the regulation of innate and adaptive immune responses. (bloodjournal.org)
  • TLRs are mainly expressed in immune cells and recognize microbial products to trigger innate immune responses [ 8 , 9 ]. (hindawi.com)
  • n = 13) Gag-specific responses, as assessed by gamma interferon enzyme-linked immunospot assay, were selected from 288 highly active antiretroviral therapy (HAART)-naive HIV-1 clade C-infected South Africans, matching groups for total magnitude of HIV-specific CD8 T-cell responses and CD4 T-cell counts. (pubmedcentralcanada.ca)
  • As previously shown in subjects with low viremia, CD8 T cells from high Gag responders exhibited a more polyfunctional cytokine profile and a stronger ability to proliferate in response to HIV stimulation than did low Gag responders, which mainly exhibited monofunctional CD8 T-cell responses. (pubmedcentralcanada.ca)
  • We conclude that it is not the overall magnitude but rather the breadth, magnitude, and functional capacity of CD8 T-cell responses to certain conserved proteins, like Gag, which predict effective antiviral HIV-specific CD8 T-cell function. (pubmedcentralcanada.ca)
  • In contrast, non-Gag-specific T-cell responses, as shown in some studies, did not contribute to immune control. (pubmedcentralcanada.ca)
  • The functional mechanism underlying enhanced viral control by Gag-specific CD8 T-cell responses has not been determined. (pubmedcentralcanada.ca)
  • These data provide first evidence for a key regulatory role for PTP1B in mediating a central DC function of initiating adaptive immune responses in response to innate immune cell activation. (sigmaaldrich.com)
  • ref. 2 ) and with the mRNA encoding CEA ( 3 ) and measured low frequencies of CEA-specific T-cell responses in a few patients. (aacrjournals.org)
  • Conversely, the response to the same antigen, presented in different immunization regimens, elicited a response typically balanced between Tfh and T helper 1 cells. (frontiersin.org)
  • Furthermore, immunization with soluble E6 and E7 fusion Igs in mice resulted in antigen-specific activation of T helper 1 (Th1) cells. (elsevier.com)
  • Fourteen patients (11 with colorectal cancer and 3 with non-small cell lung cancer) were enrolled and 12 completed at least one cycle of immunization. (aacrjournals.org)
  • To present antigens effectively, DCs must undergo maturation, a process triggered by various signals that induces phenotypic changes enabling the functional priming of T cells. (pnas.org)
  • Monophosphoryl lipid A plus IFNgamma maturation of dendritic cells induces antigen-specific CD8+ cytotoxic T cells with high cytolytic potential. (nih.gov)
  • Our results demonstrate that Pdx1 induces the expression of multiple genes related to endocrine pancreas development and islet function in these liver cells. (diabetesjournals.org)
  • Recent studies have shown that ectopic and transient expression of the transcription factor Pdx1 in the mouse liver induces transdifferentiation into pancreatic cells, including both exocrine and endocrine cells, and reduces hyperglycemia in chemically induced diabetic mice ( 4 - 7 ). (diabetesjournals.org)
  • These data clearly demonstrate that H. pylori induces a strong activation and maturation of human immature DCs. (asm.org)
  • Because we observed that monocyte-derived DCs (mo-DCs) were extremely sensitive to maturation, we sought an alternative source of DCs that would be more refractory to maturation while still being easily accessible from peripheral blood. (pnas.org)
  • Not only is encountering ligand in the thymus not required for γδ T cells to mature and exit to the periphery, but antigen naïve γδ T cells appear to constitute a large fraction of the peripheral repertoire. (pubmedcentralcanada.ca)
  • Studies also have demonstrated that peripheral dendritic cells mature in the spleen and do so in a process that is dependent on Flt3 expression. (the-rheumatologist.org)
  • These mice contain normal numbers of peripheral B-cells and normal serum IgM and IgG titres of ES cell-derived allotype, demonstrating that HSA expression on B-cells is not an absolute requirement for their maturation. (uzh.ch)
  • Pillars Article: Identification of a novel cell type in peripheral lymphoid organs of mice. (semanticscholar.org)
  • T cells make use of different V gene sections to encode TCRs at different peripheral sites (12). (ourworldisblue.com)
  • Mature B cells in the peripheral blood are tested for their ability to recognize foreign antigens. (news-medical.net)
  • The peripheral lymphoid organs are the sites of lymphocyte activation by antigens . (wikipedia.org)
  • The cells of the immune system originate in the _____, migrate through the _____ and ______, then ____ and _____ in peripheral tissues. (brainscape.com)
  • Direct analysis of peripheral blood mononuclear cells using the ELISpot assay showed an increase in the frequency of CEA-specific T cells in 10 patients (range, 10-541 CEA-specific cells/10 5 peripheral blood mononuclear cells). (aacrjournals.org)
  • Subsequently, in peripheral blood and cervical lymph nodes, a 95% decrease of CD8(+) and a 50 to 80% decrease of CD4(+) T cells were demonstrated upon maturation from recent thymic migrants to mature peripheral T cells, leaving the BB rat with a severely reduced T cell population, consisting of CD4(+) T cells and a minute population of CD8(+) T cells. (rug.nl)
  • DC maturation may be initiated by the engagement of different surface receptors, including certain cytokine receptors (such as TNFR), Toll-like receptors, CD40, and FcRs. (pasteur.fr)
  • Importantly, Syk was also required for the induction of DC maturation and IL-12 production after FcR engagement, but not after engagement of other surface receptors, such as TNFR or Toll-like receptors. (pasteur.fr)
  • Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors. (semanticscholar.org)
  • T cells can be genetically modified to express chimeric antigen receptors (CARs) that specifically target malignancy-associated antigens. (careacross.com)
  • Danger signals generated by cellular damage are recognized by host innate immune cells via innate immune signaling receptors, called pattern recognition receptors (PRRs). (nature.com)
  • Role and receptors of NK cells (NKC and LRC). (unibo.it)
  • In the absence of proper Skint1 expression, the epidermal layer lacks the invariant Vδ1+Vγ5+ DETCs (iDETCs) found in normal mice and is instead populated by γδ T cells that express diverse TCR V genes. (pubmedcentralcanada.ca)
  • Transgenic mice overexpressing BAFF have a greatly elevated number of mature B cells and an increased number of effector T cells in their spleen and mesenteric lymph nodes ( 6 ). (rupress.org)
  • B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24). (uzh.ch)
  • In order to elucidate the function of HSA, we analysed chimaeric mice that were generated by targeted disruption of both HSA alleles in ES cells. (uzh.ch)
  • Furthermore, using a syngeneic T cell activation model, we found that DC2.4/Hlx could obviously present ovalbumin (OVA) antigen to T cell in OVA pre-immunized mice. (nih.gov)
  • B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice. (semanticscholar.org)
  • I. Slower maturation of mitogen and antigen-responsive B cells in mice expressing an X-linked defect. (rupress.org)
  • The effect of age on the mitogenic and antigenic responsiveness of B cells is examined in spleen cell cultures of CBA/N and (CBA/N X DBA/2) F1 mice. (rupress.org)
  • Whereas male F1 mice at 60 wk of age showed an equivalent percentage of Ig-bearing spleen cells and a similar mitogenic responsiveness to LPS when compared to adult female F1 mice, the frequency of SRBC-reactive B-cell precursors remained threefold lower. (rupress.org)
  • These findings reveal that there is a slower maturation of B cells in mice expressing the X-linked defect and suggests that the defect has differential effects on the mechanisms of antigen and mitogen activation of B cells. (rupress.org)
  • We followed the consequences of DEC-205 antigen targeting in naive mice with a polyclonal T cell repertoire. (rupress.org)
  • However, whereas the avidity of memory cells in normal mice increased dramatically with repeated immunizations, avidity maturation was limited for self-specific CD8 T cells. (umassmed.edu)
  • It has recently been shown in mice that Th22 cells can be skewed by IL-6 and produce mainly IL-22 but little IL-17 (8). (ourworldisblue.com)
  • The levels of IFN- γ , IL-4, and IL-10 in CD4 + T cells cocultured with dendritic cells from different types of mice were determined with ELISPOT or ELISA method. (hindawi.com)
  • Pdx1 has been shown to convert hepatocytes into both exocrine and endocrine pancreatic cells in mice, but it fails to selectively convert hepatocytes into pure insulin-producing cells (IPCs). (diabetesjournals.org)
  • Yet when WB-1 cells are transplanted into diabetic NOD- scid mice, these genes become activated and hyperglycemia is completely reversed. (diabetesjournals.org)
  • Knockout and transgenic mice have been developed for specific T-cell disorders and are recognized to have helped predict human genetic disorders. (medscape.com)
  • In their new study, Arnaout and colleagues sequenced 2.8 million VDJ-recombined heavy-chain genes from immature and mature B-cell subsets in mice. (eurekalert.org)
  • This effect was both distinct from, and larger than previously described maturation-associated changes in CDR3 in the mice. (eurekalert.org)
  • Recent groundbreaking studies in rodents indicate that B cells are responsible for SCI-induced autoimmunity. (semanticscholar.org)
  • The presence of autoimmunity against islet antigens is detected by measuring autoantibodies in the blood and it is assumed that seroconversion to islet autoantibody positivity is accompanied by activation of islet autoreactive T cells. (diabetesjournals.org)
  • We predict, therefore, that the combination of an HLA genotype-determined islet autoreactive naïve T-cell population, homeostatic expansion mechanisms, and immune competence provides a highly favorable environment for islet autoimmunity and, in part, determines the high incidence of seroconversion observed at ∼1 year of age. (diabetesjournals.org)
  • Immune tolerance to self-antigens is a complex process that utilizes multiple mechanisms working in concert to maintain homeostasis and prevent autoimmunity. (umassmed.edu)
  • gene) are one of the T helper cell subsets that mediates extracellular pathogen clearance but also causes autoimmunity when dysregulated (1C5). (ourworldisblue.com)
  • The dysregulation of this machinery underlies the unwarranted expansion or destruction of cell numbers that occurs in human diseases like cancer, autoimmunity, hyperinflammatory states and neurodegenerative disease. (hopkinsmedicine.org)
  • [ 1 ] These heterogeneous disorders are characterized by an incomplete reduction in T-cell number or activity, autoimmunity, inflammatory diseases, and elevated immunoglobulin E (IgE) production. (medscape.com)
  • T-cell disorders in which autoimmunity and polyendocrinopathy predominate have recently been elucidated, and more will certainly be discovered as pathways for T-cell signal transduction are better understood. (medscape.com)
  • Unlike severe T-cell immunodeficiencies, however, partial immunodeficiencies are commonly associated with hyper-immune dysregulation, including autoimmunity, inflammatory diseases, and elevated IgE production. (medscape.com)
  • B cells play essential roles in vaccination, infection, autoimmunity, aging and cancer," explains senior author Ramy Arnaout, MD, DPhil, an investigator in the Department of Pathology at BIDMC and Assistant Professor of Pathology at Harvard Medical School whose work focuses on the emerging field of high-throughput multimodality immunology, also known as immunomics. (eurekalert.org)
  • We employed Drosophila hemocytes, which are similar to mammalian professional macrophages, to establish a model of phagosome maturation. (mdpi.com)
  • macrophages, neutrophils, and dendritic cells [ 4 ]. (mdpi.com)
  • Some of these activities have been linked to the ability of CCR5 to recruit macrophages and other immune suppressor cells to the tumor site, creating an inflammatory environment that promotes tumor progression and immune evasion ( 16-19 ). (aacrjournals.org)
  • miR155 expression is induced during the activation of T cells, B cells, monocytes, macrophages, and dendritic cells (DCs), suggesting that it plays multiple roles in the immune system. (bloodjournal.org)
  • Our previous experiments indicated that MBP induced the activation of Th1 cells, NK cells, and macrophages, indicating that MBP has potent immune-enhancing activities. (hindawi.com)
  • L. monocytogenes can infect a variety of cell types, including macrophages, epithelial cells, fibroblasts, and hepatocytes ( 57 ). (asm.org)
  • wherein said first cells are antigen presenting cells selected from the group consisting of macrophages, B-cells and dendritic cells, and said second cells are selected from the group consisting of tumor cells and virally infected cells. (freepatentsonline.com)
  • Analysis of miR155-deficient DCs demonstrated that miR155 induction is required for efficient DC maturation and is critical for the ability of DCs to promote antigen-specific T-cell activation. (bloodjournal.org)
  • The immune effects of PO are associated with myeloid cell activation, and little is known about the action of PO on lymphocyte lineages, such as natural killer (NK) and T cells. (medworm.com)
  • What types of cells do myeloid cells become? (brainscape.com)
  • Where do myeloid cells go? (brainscape.com)
  • We show that myeloid cell-specific PTP1B deletion also causes decreased migratory capacity of epidermal DC, as well as reduced CCR7 expression and chemotaxis to CCL19 by BMDC. (sigmaaldrich.com)
  • Maturation linked expression of a myeloid cell surface antigen. (biomedsearch.com)
  • Extensive Immunohistochemical analysis of normal tissue expression using commercially available polyclonal antibodies demonstrated expression within B-lineage cells across a number of tissues as expected. (oncotarget.com)
  • The blood does not come into direct contact with the parenchymal cells and tissues in the body (except in case of an injury causing rupture of one or more blood vessels), but constituents of the blood first exit the microvascular exchange blood vessels to become interstitial fluid , which comes into contact with the parenchymal cells of the body. (wikipedia.org)
  • They do this by migrating from the tissues to the T cell area of the secondary lymphoid tissues. (sigmaaldrich.com)
  • They traffic from the blood to the tissues where, while immature, they capture antigens. (psu.edu)
  • They then leave the tissues and move to the draining lymphoid organs where, converted into mature DC, they prime naive T cells. (psu.edu)
  • In the development of strategies to vaccinate cancer patients with tumor antigens, soluble whole proteins produced by recombinant technologies are attractive agents because they include all potential epitopes recognized by antibodies and T cells. (pnas.org)
  • To research the maturation regulation of dendritic cells (DCs) pulsed with hepatocellular carcinoma (HCC) cell soluble antigens . (bvsalud.org)
  • The characteristics of DCs had changed after loaded with soluble antigens of HCC. (bvsalud.org)
  • Soluble E6 and E7 fusion Igs effectively induced maturation of DCs. (elsevier.com)
  • Antibodies are effective against extracellular pathogens, but cannot directly access intracellular pathogens, such as viruses or intracellular bacteria, and are also largely ineffective in eliminating cancer cells. (frontiersin.org)
  • B cells secrete antibodies in response to invasion by foreign pathogens. (news-medical.net)
  • They found that B cells for which antibodies use V genes that encode 'looser' elbows were more likely to mature, regardless of their CDR3 sequence. (eurekalert.org)
  • CDla + precursors give rise to cells characterized by the expression of Birbeck granules, the Lag antigen and E-cadherin, three markers specifically expressed on Langerhans cells in the epidermis. (psu.edu)
  • Interestingly, the CD14 + precursors, but not the CDla + precursors, represent bipotent cells that can be induced to differentiate, in response to M-CSF, into macrophage-like cells, lacking accessory function for T ceils. (psu.edu)
  • In the case of αβ T cells, thymic development entails endogenous ligand driven positive and negative selection, which determine what αβ T cell can recognize and whether these T cells will develop into CD4 + helper or CD8 + cytolytic T cells. (pubmedcentralcanada.ca)
  • The lipopeptides contained a single CD4(+) helper T-cell epitopes, one of a number of human leucocyte antigen (HLA)-A2-restricted cytotoxic T-cell epitope and the lipid Pam2Cys. (semanticscholar.org)
  • Here, we report an uncommonly strong bias toward follicular helper (Tfh) differentiation of CD4 + T cells reactive with a retroviral envelope glycoprotein model antigen, presented in its natural context during retroviral infection. (frontiersin.org)
  • Several divergent and often competing programmes of CD4 + T cell differentiation are now well recognized, leading to the development of distinct functional subsets, including T helper (Th) 1, 2, or 17 cells, follicular helper (Tfh) cells, and regulatory T (Treg) cells ( 1 - 5 ). (frontiersin.org)
  • Although it remains to be determined whether Th22 and Th17 cells belong to the same subset of T helper cells with different effector cytokine properties, Th22 cells appear to be more effective than Th17 cells during the clearance of and enteropathogenic infections responsible for the deaths of several hundred thousand children in developing countries each year. (ourworldisblue.com)
  • A T helper cell activated with the same antigen recognizes and binds the antigen complex, triggering a cascade of signals. (news-medical.net)
  • DCs were differentiated either from CD34 � hematopoietic progenitor cells (HPCs) cultured with granulocyte/macrophage colony-stimulating factor (GM-CSF) plus tumor necrosis factor (TNF)- � or from monocytes cultured with GM-CSF plus interleukin 4. (psu.edu)
  • These results highlight the importance of adaptive type 1 immune mechanisms for host resistance to blood-stage malaria and the need to identify critical components of the innate immune response that promote development of IFN-γ-producing CD4 + Th1 cells. (jimmunol.org)
  • On the other hand, neonates have active homeostatic mechanisms, including a high cell cycle rate and an increased serum IL-7 concentration favoring clonal expansion ( 6 - 8 ). (diabetesjournals.org)
  • Both periods are characterized by the presence of autoantigen-responsive naïve T cells and T cells that are highly sensitive to homeostatic expansion mechanisms. (diabetesjournals.org)
  • P-glycoprotein (P-gp) expressed on human antigen presenting cells (APC) regulates alloantigen-dependent T-cell activation, but the associated mechanisms are not well understood. (meta.org)
  • Thus, the self-reactive T cell repertoire is controlled by overlapping mechanisms influenced by antigen dose. (umassmed.edu)
  • Intracellular NOD2 in DCs could be activated by MDP and this activation could promote maturation and the ability to prime Th0 cells to Th2 cells of DCs exposed to P. gingivalis -LPS. (alliedacademies.org)
  • However, the activation of naïve T cells is compromised at birth and appears fully competent at 8 months of age. (diabetesjournals.org)
  • CCR5 activation in CD4 + cells resulted in CD40L upregulation, leading to full maturation of antigen-presenting cells and enhanced CD8 + T-cell crosspriming and tumor infiltration. (aacrjournals.org)
  • The challenge for immunotherapy is thus to identify cell networks and molecular factors that enhance the expansion and activation of tumor-reactive effector T cells. (aacrjournals.org)
  • CCL5 produced by tumor-infiltrating CD4 + T cells is also involved in recruiting APC to the tumor site where, after CD40-mediated activation, they become competent to crosspresent and trigger CD8 + T cells in the tumor parenchyma ( 7 ). (aacrjournals.org)
  • It remains unclear whether CCR5 effects on T-cell function are relevant in physiopathologic situations, or are restricted to certain conditions of immune activation. (aacrjournals.org)
  • Although viral entry and expression of viral proteins happen very fast, DCs need time to acquire an activated phenotype that allows optimal activation of naïve T cells [ 2 ]. (springer.com)
  • A strong increase in miR155 expression was found to be a general and evolutionarily conserved feature associated with the activation of DCs by diverse maturation stimuli in all DC subtypes tested. (bloodjournal.org)
  • TLR2/TLR4 is important in the maturation and activation of dendritic cells and the activation of Th1 cells induced by stimulation with MBP and BCG. (hindawi.com)
  • The results above indicate that the combination of MBP and BCG induced the maturation and activation of dendritic cells and promoted Th1 activation via TLR2/TLR4. (hindawi.com)
  • Any refs to apoptosis of other cells triggering IL-1 production, activation (cleavage by ICE? (bio.net)
  • Activation leads to clonal expansion and affinity maturation. (wikipedia.org)
  • In the present study we determined if p53-mediated neuronal cell death required caspase activation. (jneurosci.org)
  • However, the relative importance of caspase activation in neurons depends on the developmental status of the cell and the specific nature of the death stimulus. (jneurosci.org)
  • Although the exact mechanism by which Bax promotes cell death is not known, several studies have suggested that Bax may cooperate with bcl-2 or bcl-X L , or it may act independently to regulate the activation of caspases (J. G. (jneurosci.org)
  • We therefore examined whether caspases are activated in neurons after injury in a p53-dependent manner and, if so, whether such activation is essential for p53-dependent neuronal cell death. (jneurosci.org)
  • A key role for PTP1B in dendritic cell maturation, migration, and T cell activation. (sigmaaldrich.com)
  • A common goal of cancer vaccines in development is the activation of high levels of antigen-specific T cells. (aacrjournals.org)
  • discussed below), it would be interesting to determine whether or not these 'replacement' DETCs have encountered ligand during development in the thymus and if these cells function as antigen naïve γδ T cells. (pubmedcentralcanada.ca)
  • Among the many tumor antigens described, the model antigen, carcinoembryonic antigen (CEA), is of particular interest because it is widely expressed in gastrointestinal, lung, breast, and other malignancies. (aacrjournals.org)
  • Among patients with MM, sBCMA levels correlated with the percentage of malignant cells, giving rise to the concept that sBCMA may reflect a patient's tumor burden. (wikipedia.org)
  • However, maturation in the presence of a cytokine mixture up-regulated expression of these components in DC obtained from normal donors and patients with cancer. (jimmunol.org)
  • New research by investigators in this subject area suggests that, in patients with RA, survivin is essential for the survival of leukocytes as they differentiate and mature into dendritic cells, thereby raising it as a potential therapeutic target. (the-rheumatologist.org)
  • Autoreactive T cells can be identified in patients with type 1 diabetes and nondiabetic control subjects ( 2 ). (diabetesjournals.org)
  • Patients have naïve and memory autoantigen-responsive CD4 + and CD8 + T cells, whereas autoreactive T cells identified in control subjects appear to be confined to the naïve T-cell compartment ( 3 ). (diabetesjournals.org)
  • Specifically, patients with serum B-cell maturation antigen levels above the median level at the time of starting frontline (P = 0.0043) or a new salvage therapy (P = 0.0044) were found to have shorter progression-free survival. (imbcr.org)
  • Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer patients, making it an ideal target for cancer immunotherapy. (google.co.uk)
  • In this study, we analysed differentiation, maturation, and antigen-presenting function of DC derived from XLA patients (XLA-DC) as compared to DC from age-matched healthy subjects (healthy-DC). (torvergata.it)
  • Common tumor vaccination strategies utilizing peptide-pulsed dendritic cells (DC) are limited to targeting antigens with known epitopes in patients expressing a defined restricting allele and can result in the preferential induction of low-avidity T cells that fail to recognize tumor cells. (duke.edu)
  • The purpose of this phase I clinical trial is to test the safety of these CAR T cells in patients with myeloma. (clinicaltrials.gov)
  • A cohort of patients will be treated with CAR T cell therapy and concomitant Lenalidomide. (clinicaltrials.gov)
  • Thus, the conversion of hepatocytes into endocrine pancreatic cells may be a viable option for cell replacement therapy in patients with type 1 diabetes. (diabetesjournals.org)
  • The increased risk for reactive airway disease and thyroiditis in patients with DGS and the high incidence of autoimmune hemolytic anemia in patients with WAS are examples of defective T-cell/B-cell interactions that result in self-reactivity. (medscape.com)
  • In contrast, strong TCR signaling leading to TCR downregulation and induction of LAG3 expression in high TCR avidity clonotypes restrained CD4 + T cell commitment and further differentiation. (frontiersin.org)
  • GPIb-V-IX expression appeared at day 3 of culture and was strictly dependent on MK cytokine induction, whereas GPIIb was already present in immature CD34 + cells. (bloodjournal.org)
  • Several studies have shown inhibitory effects of H. pylori on cell proliferation ( 11 , 24 - 26 , 60 ), and the induction of H. pylori -specific regulatory T cells that actively suppress T-cell response have been described ( 31 ). (asm.org)
  • B cells are activated in the secondary lymphoid organs (SLOs), which are the lymph nodes, tonsils, spleen, Peyer's patches and mucosa associated lymphoid tissue (MALT). (news-medical.net)
  • Remarkably, this IFN-γ-inducible characteristic was due neither to enhanced antigen uptake nor to facilitated antigen processing in LCs. (pnas.org)
  • After 48 h of treatment, phenotypic figures and antigen uptake ability were determined by FACS analysis. (mdpi.com)
  • The high amounts of induced CTLs are functional as they produce IFNgamma and lyse target cells and this cytolytic activity is antigen specific and HLA restricted. (nih.gov)
  • It has been known for some time that functional properties of dendritic cells (DC), and in particular their ability to process and present Ags to T cells, can be modulated by cytokine-induced maturation and by interactions with tumor cells. (jimmunol.org)
  • It has been recognized for some time that functional changes, in particular alterations in the ability to process and present Ags to T cells, are associated with DC maturation ( 1 , 2 ) and with exposure of DC to tumor cells ( 6 , 7 , 8 ). (jimmunol.org)
  • The relative balance of CD4 + T cell differentiation to one or more of these functional subsets largely depends on a multitude of T cell-extrinsic factors, with the cytokine milieu naïve T cells encounter during the priming phase playing a major role ( 1 - 5 ). (frontiersin.org)
  • Alternatively, the maturation phenotype and functional quality of HIV-specific CD8 T cells may be the more critical predictors of the effectiveness of a virus-specific response ( 1 , 4 , 7 , 15 , 20 , 25 ). (pubmedcentralcanada.ca)
  • First, DCs efficiently process antigens, including complex microbes and tumor cells, and display these on both MHC class I and II products to CD8 + and CD4 + T cells, respectively ( 7 , 8 ). (rupress.org)
  • Results shown that over-expressed Hlx in DC2.4 up-regulated the transcription and expression of IFN-γ, increased the expression of maturation makers including CD40, CD80, CD86, MHC-I and MHC-II. (nih.gov)
  • Studies aimed at correlating overall quantitative differences in breadth or magnitude of the gamma interferon (IFN-γ)-positive HIV-specific CD8 T-cell response and plasma HIV viral loads have failed to show an association with control of viremia ( 2 , 18 ). (pubmedcentralcanada.ca)
  • Fortunately, it is known that the host immune system can recognize, eliminate, and protect the body from viral or bacterial infections as well as the extension of transformed cells (including precancer cells) [ 5 ]. (hindawi.com)
  • Viral gene delivery into dendritic cells has been successfully done using poxviruses, herpes simplex, adenovirus, retrovirus, lentivirus, and adeno-associated virus (reviewed in ref. 8 ). (aacrjournals.org)
  • Finally, stunted Th1 differentiation, correlating with limited IL-2 availability in retroviral infection, provided permissive conditions for Tfh development, suggesting that Tfh differentiation is the default program of envelope-reactive CD4 + T cells. (frontiersin.org)
  • Indeed, the ratio of Tfh to Th1 cells in the CD4 + T cell response to acute lymphocytic choriomeningitis virus (LCMV) has been amply reported close to 1 and 2 for LCMV Armstrong ( 9 - 14 ) and clone 13 (Cl13) ( 15 - 19 ), respectively, and similar results were also reported for influenza A virus infection ( 20 - 23 ). (frontiersin.org)
  • In this study, we investigated the requirement of the Listeria monocytogenes broad-range phospholipase C (PC-PLC) during infection of human epithelial cells. (asm.org)
  • However, L. monocytogenes can escape from primary vacuoles in the absence of LLO during infection of human epithelial cell lines Henle 407, HEp-2, and HeLa. (asm.org)
  • These cells can be found mainly in the epidermis to protect against infection spreading through the skin. (wikipedia.org)
  • Previously, we showed that the combination of monophosphoryl lipid A (MPLA) with IFNgamma generates mature DCs that produce IL-12 and polarize CD4(+) T cells towards a Th1 phenotype. (nih.gov)
  • Consistent with this, DCs efficiently presented CD1b-restricted lipid Ags to specific T cells similarly in immature and mature DCs. (nih.gov)
  • Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments. (semanticscholar.org)
  • In this study, we report an RNA transfection strategy that routinely achieves expression in 40-50% of mature DC, which are better stimulator cells. (duke.edu)
  • PO does not affect dendritic cell (DC) viability and increases the expansion of immature DC (iDC) and mature DC (mDC) at 100 μg/ml, and it stimulates expression of several DC co-stimu. (medworm.com)
  • HSCs become multipotent progenitor (MPP) cells, then common lymphoid progenitor (CLP) cells, and then go through several more stages of development to become a mature B cell. (news-medical.net)
  • In the spleen, B cells are monitored in transition from immature to mature cells. (news-medical.net)
  • Mature T cells join B cells in search of pathogens. (wikipedia.org)
  • But in agreement with recent observations (60), mature DCs that have lost their aptitude to internalize antigens =-=(21, 44, 61)-=- cannot be recruited by these chemokines anymore. (psu.edu)
  • In contrast, the CD14 + progenitors mature into CDla + DC lacking Birbeck granules, E-cadherin, and Lag antigen but expressing CD2, CD9, CD68, and the coagulation factor XIlla described in dermal dendritic cells. (psu.edu)
  • The two mature DC were equally potent in stimulating allogeneic CD45RA + naive T cells. (psu.edu)
  • Furthermore, as related to the number of available mature TCR(high) Single positive thymocytes, numbers of CD4(+) and CD8(+) T cells most recently migrated from the thymus were severely decreased in BB blood, indicating either reduced thymic output or rapid cell death after migration. (rug.nl)
  • Rather, IFN-γ acted at least in part by potentiating the maturation of otherwise refractory LCs, enabling in turn exogenous antigen to reach the processing machinery. (pnas.org)
  • A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals. (semanticscholar.org)
  • Closed system generation of dendritic cells from a single blood volume for clinical application in immunotherapy. (semanticscholar.org)
  • and positive regulation of cytotoxic T cell differentiation. (mcw.edu)
  • In the present report we incubated a human liver cell line in the presence of either F. hepatica excretory/secretory material (FhES) or recombinant phosphoglycerate kinase (FhPGK). (springer.com)
  • Recombinant attenuated poxviruses (vaccinia, fowlpox, and canarypox) are notable for their ability to accept and express multiple transgenes and for their efficient transfection of most mammalian cells ( 9 ). (aacrjournals.org)
  • To be naturally processed into MHC/peptide complexes, proteins have to be taken up by antigen-presenting cells, of which dendritic cells (DCs) are perhaps the most sophisticated kind due to their array of unique characteristics. (pnas.org)
  • Unexpectedly, the αDEC-205 antigen conjugates, given s.c., targeted to dendritic cells systemically and for long periods, and ovalbumin peptide was presented on MHC class I for 2 weeks. (rupress.org)
  • that is, many TCRs recognize the same antigen peptide and many antigen peptides are recognized by the same TCR. (wikipedia.org)
  • The Constant region is proximal to the cell membrane, followed by a transmembrane region and a short cytoplasmic tail, while the Variable region binds to the peptide/MHC complex. (wikipedia.org)
  • [8] CDR3 is the main CDR responsible for recognizing processed antigen , although CDR1 of the alpha chain has also been shown to interact with the N-terminal part of the antigenic peptide, whereas CDR1 of the β-chain interacts with the C-terminal part of the peptide. (wikipedia.org)
  • It is a pore-forming peptide, as it can puncture a microbial cell wall, allowing for other death-inducing enzymes to enter the microbe and cause microptosis. (wikipedia.org)
  • We investigated the interaction between H. pylori and human dendritic cells. (asm.org)
  • We developed a system that revealed a population of self-specific CD8 T cells within the endogenous T cell repertoire. (umassmed.edu)
  • However, the role of ligand-mediated selection in γδ T cell development and function has been less clear. (pubmedcentralcanada.ca)
  • Although neither the invariant TCR-antigen, nor the molecular entity on the iDETC which interacts with Skint1 has been identified, several indirect evidences indicate that the 'replacement' DETCs do not recognize the same ligand as the iDETCs. (pubmedcentralcanada.ca)
  • Further, up-regulation of self-antigen expression in dendritic cells using an inducible system promoted programmed death-1 expression, but not clonal expansion of preexisting memory cells. (umassmed.edu)
  • Avidity maturation of memory CD8 T cells is limited by self-antigen ex" by Michael J. Turner, Evan Robert Jellison et al. (umassmed.edu)
  • and Lefrancois, Leo, "Avidity maturation of memory CD8 T cells is limited by self-antigen expression" (2008). (umassmed.edu)