Monobactams
beta-Lactamases
Ceftazidime
Microbial Sensitivity Tests
beta-Lactams
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Cephalosporins
Pseudomonas aeruginosa
beta-Lactam Resistance
Cefoperazone
Gram-Negative Bacteria
Klebsiella pneumoniae
Enterobacter
Amikacin
Imipenem
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Tobramycin
Piperacillin
Isoelectric Focusing
Drug Resistance, Microbial
Clavulanic Acid
Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
Carbapenems
Thienamycins
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Klebsiella
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
Citrobacter
Azabicyclo Compounds
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Serratia marcescens
Gentamicins
Enterobacter cloacae
Drug Resistance, Multiple, Bacterial
Drug Resistance, Bacterial
Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Half-Life
Cefuroxime
Drug Therapy, Combination
Proteus vulgaris
Gram-Negative Aerobic Bacteria
Penicillins
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Bacteria
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Vancomycin
Clavulanic Acids
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Acinetobacter
Aminoglycosides
Kanamycin
Conjugation, Genetic
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
Proteus mirabilis
Lactams
Salmonella paratyphi A
Plasmids
Muramoylpentapeptide Carboxypeptidase
Penicillanic Acid
Gram-Negative Bacterial Infections
Penicillin-Binding Proteins
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
Chromatography, High Pressure Liquid
Paratyphoid Fever
Sulbactam
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
Feces
Bile
Acinetobacter baumannii
Infusions, Parenteral
Peptidyl Transferases
Colistin
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Rabbits
Meningitis, Haemophilus
Injections, Intramuscular
Aztreonam
Ampicillin
Macaca fascicularis
Minocycline
Integrons
Administration, Inhalation
Endocarditis, Bacterial
Blood Proteins
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Drug Resistance, Multiple
Electrophoresis, Gel, Pulsed-Field
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
Neisseria gonorrhoeae
Amino Acid Sequence
Drug Combinations
Double-Blind Method
Biological Availability
Enzyme Induction
Base Sequence
Cloning, Molecular
Chromatography, Thin Layer
Phenotype
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Sequence Analysis, DNA
Substrate Specificity
Treatment Outcome
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Mutation
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Protein Binding
Dose-Response Relationship, Drug
Effects of antibiotic therapy on Pseudomonas aeruginosa-induced lung injury in a rat model. (1/239)
The effect of antibiotics on the acute lung injury induced by virulent Pseudomonas aeruginosa PA103 was quantitatively analyzed in a rat model. Lung injury was induced by the instillation of PA103 directly into the right lower lobes of the lungs of anesthetized rats. The alveolar epithelial injury, extravascular lung water, and total plasma equivalents were measured as separate, independent parameters of acute lung injury. Four hours after the instillation of PA103, all the parameters were increased linearly depending on the dose of P. aeruginosa. Next, we examined the effects of intravenously administered antibiotics on the parameters of acute lung injury in D-galactosamine-sensitized rats. One hour after the rats received 10(7) CFU of PA103, an intravenous bolus injection of aztreonam (60 mg/kg) or imipenem-cilastatin (30 mg/kg) was administered. Despite an MIC indicating resistance, imipenem-cilastatin improved all the measurements of lung injury; in contrast, aztreonam, which had an MIC indicating sensitivity, did not improve any of the lung injury parameters. The antibiotics did not generate different quantities of plasma endotoxin; therefore, endotoxin did not appear to explain the differences in lung injury. This in vivo model is useful to quantitatively compare the efficacies of parenteral antibiotic administration on Pseudomonas airspace infections. (+info)In-vitro effects of a combination of antipseudomonal antibiotics against multi-drug resistant Pseudomonas aeruginosa. (2/239)
We evaluated the in-vitro effects of various combinations of five types of widely used antipseudomonal antibiotics (piperacillin, meropenem, ceftazidime, aztreonam and amikacin) against six Pseudomonas aeruginosa strains that were resistant to each of these antibiotics. Among two-drug combinations, the combinations of two beta-lactam antibiotics inhibited growth of one to three P. aeruginosa strains, while those of one beta-lactam antibiotic and amikacin inhibited growth of two to four strains. Among three-drug combinations, the combinations of three beta-lactam antibiotics inhibited growth of four to five strains, and those of two beta-lactam antibiotics and amikacin inhibited growth of five strains. These results suggest the potential usefulness of a combination of two beta-lactam antibiotics and amikacin or that of three beta-lactam antibiotics in treating multi-drug resistant P. aeruginosa infections. (+info)Detection and reporting of organisms producing extended-spectrum beta-lactamases: survey of laboratories in Connecticut. (3/239)
Extended-spectrum beta-lactamases (ESBLs) are enzymes produced in some gram-negative bacilli that mediate resistance to extended-spectrum cephalosporins and aztreonam. They are most common in Klebsiella spp. and Escherichia coli but are present in a variety of Enterobacteriaceae. Resistance mediated by these enzymes can be difficult to detect depending on the antimicrobial agents tested. AmpC beta-lactamases are related to the chromosomal enzymes of Enterobacter and Citrobacter spp. and also mediate resistance to extended-spectrum cephalosporins and aztreonam in addition to cephamycins, such as cefoxitin. Unlike ESBLs, however, AmpC beta-lactamases are not inhibited by clavulanic acid or other similar compounds. To assess the abilities of various antimicrobial susceptibility testing methods to detect ESBLs, we sent three ESBL-producing organisms, one AmpC-producing organism, and a control strain that was susceptible to extended-spectrum cephalosporins to 38 laboratories in Connecticut for testing. Eight (21.0%) of 38 labs failed to detect extended-spectrum cephalosporin or aztreonam resistance in any of the ESBL- or AmpC-producing isolates. Errors were encountered with both automated and disk diffusion methods. Conversely, seven (18.4%) labs categorized at least some of the four resistant isolates as potential ESBL producers and reported the results with the extended-spectrum cephalosporins and aztreonam as resistant as suggested by current National Committee for Clinical Laboratory Standards (NCCLS) guidelines. The percentage of laboratories that failed to detect resistance in the ESBL or AmpC isolates ranged from 23.7 to 31.6% depending on the type of enzyme present in the test organism. This survey suggests that many laboratories have difficulty detecting resistance in ESBL and AmpC-producing organisms and may be unaware of the NCCLS guidelines on modifying susceptibility testing reports for ESBL-producing strains. (+info)ampR gene mutations that greatly increase class C beta-lactamase activity in Enterobacter cloacae. (4/239)
The ampC and ampR genes of Enterobacter cloacae GN7471 were cloned into pMW218 to yield pKU403. Four mutant plasmids derived from pKU403 (pKU404, pKU405, pKU406, and pKU407) were isolated in an AmpD mutant of Escherichia coli ML4953 by selection with ceftazidime or aztreonam. The beta-lactamase activities expressed by pKU404, pKU405, pKU406, and pKU407 were about 450, 75, 160, and 160 times higher, respectively, than that expressed by the original plasmid, pKU403. These mutant plasmids all carried point mutations in the ampR gene. In pKU404 and pKU405, Asp-135 was changed to Asn and Val, respectively. In both pKU406 and pKU407, Arg-86 was changed to Cys. The ease of selection of AmpR mutations at a frequency of about 10(-6) in this study strongly suggests that derepressed strains, such as AmpD or AmpR mutants, could frequently emerge in the clinical setting. (+info)Penicillin binding protein 5 affects cell diameter, contour, and morphology of Escherichia coli. (5/239)
Although general physiological functions have been ascribed to the high-molecular-weight penicillin binding proteins (PBPs) of Escherichia coli, the low-molecular-weight PBPs have no well-defined biological roles. When we examined the morphology of a set of E. coli mutants lacking multiple PBPs, we observed that strains expressing active PBP 5 produced cells of normal shape, while mutants lacking PBP 5 produced cells with altered diameters, contours, and topological features. These morphological effects were visible in untreated cells, but the defects were exacerbated in cells forced to filament by inactivation of PBP 3 or FtsZ. After filamentation, cellular diameter varied erratically along the length of individual filaments and many filaments exhibited extensive branching. Also, in general, the mean diameter of cells lacking PBP 5 was significantly increased compared to that of cells from isogenic strains expressing active PBP 5. Expression of cloned PBP 5 reversed the effects observed in DeltadacA mutants. Although deletion of PBP 5 was required for these phenotypes, the absence of additional PBPs magnified the effects. The greatest morphological alterations required that at least three PBPs in addition to PBP 5 be deleted from a single strain. In the extreme cases in which six or seven PBPs were deleted from a single mutant, cells and cell filaments expressing PBP 5 retained a normal morphology but cells and filaments lacking PBP 5 were aberrant. In no case did mutation of another PBP produce the same drastic morphological effects. We conclude that among the low-molecular-weight PBPs, PBP 5 plays a principle role in determining cell diameter, surface uniformity, and overall topology of the peptidoglycan sacculus. (+info)Differential responses of Escherichia coli cells expressing cytoplasmic domain mutants of penicillin-binding protein 1b after impairment of penicillin-binding proteins 1a and 3. (6/239)
Penicillin-binding protein 1b (PBP1b) is the major high-molecular-weight PBP in Escherichia coli. Although it is coded by a single gene, it is usually found as a mixture of three isoforms which vary with regard to the length of their N-terminal cytoplasmic tail. We show here that although the cytoplasmic tail seems to play no role in the dimerization of PBP1b, as was originally suspected, only the full-length protein is able to protect the cells against lysis when both PBP1a and PBP3 are inhibited by antibiotics. This suggests a specific role for the full-length PBP1b in the multienzyme peptidoglycan-synthesizing complex that cannot be fulfilled by either PBP1a or the shorter PBP1b proteins. Moreover, we have shown by alanine-stretch-scanning mutagenesis that (i) residues R(11) to G(13) are major determinants for correct translocation and folding of PBP1b and that (ii) the specific interactions involving the full-length PBP1b can be ascribed to the first six residues at the N-terminal end of the cytoplasmic domain. These results are discussed in terms of the interactions with other components of the murein-synthesizing complex. (+info)Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study. (7/239)
Linezolid, the first oxazolidinone, is active against gram-positive bacteria, including multidrug-resistant strains. This multinational, randomized, double-blind, controlled trial compared the efficacy, safety, and tolerability of linezolid with vancomycin in the treatment of nosocomial pneumonia. A total of 203 patients received intravenous linezolid, 600 mg twice daily, plus aztreonam, and 193 patients received vancomycin, 1 g intravenously twice daily, plus aztreonam for 7-21 days. Clinical and microbiological outcomes were evaluated at test of cure 12-28 days after treatment. Clinical cure rates (71 [66.4%] of 107 for linezolid vs. 62 [68.1%] of 91 for vancomycin) and microbiological success rates (36 [67.9%] of 53 vs. 28 [71.8%] of 39, respectively) for evaluable patients were equivalent between treatment groups. Eradication rates of methicillin-resistant Staphylococcus aureus and safety evaluations were similar between treatment groups. Resistance to either treatment was not detected. Linezolid is a well-tolerated, effective treatment for adults with gram-positive nosocomial pneumonia. (+info)SHV-27, a novel cefotaxime-hydrolysing beta-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital. (8/239)
From a collection of cefotaxime-resistant Klebsiella pneumoniae isolated from neonatal blood culture specimens in a maternity hospital in Aracaju, Brazil, two isolates (strains KPBRZ-842 and -843, indistinguishable by pulsed-field gel electrophoresis) were found to produce beta-lactamases with isoelectric points (pI) of 5.4 and 8.2, respectively. Using a gel overlay method, cefotaxime hydrolysis was shown to be associated with the pI 8.2 protein. Nucleotide sequencing of the gene encoding the pI 8.2 beta-lactamase revealed a bla(SHV-ESBL)-type gene differing from the gene encoding SHV-1 by three silent point mutations, and a fourth that resulted in an amino acid substitution, aspartate for glycine, at position 156. This novel SHV-type extended-spectrum beta-lactamase is designated SHV-27. (+info)Inhaled aztreonam lysine for chronic airway Pseudomonas aeruginosa in cystic fibrosis<...
Expanded Access for Aztreonam Lysine for Inhalation in Canadian Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Airway...
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Monobactam
Aztreonam is a commercially available monobactam antibiotic. Other examples of monobactams are tigemonam, nocardicin A, and ... which contains an identical side chain as aztreonam. Monobactams can trigger seizures in patients with history of seizures, ...
Cystic fibrosis
Inhaled therapy with antibiotics such as tobramycin, colistin, and aztreonam is often given for months at a time to improve ... McCoy KS, Quittner AL, Oermann CM, Gibson RL, Retsch-Bogart GZ, Montgomery AB (November 2008). "Inhaled aztreonam lysine for ...
Ecthyma gangrenosum
antipseudomonal penicillins, aminoglycosides, fluoroquinolones, third generation cephalosporins or ceftriaxone aztreonam can be ...
Cholecystitis
For penicillin allergic people, aztreonam or a quinolone with metronidazole may be used.[citation needed] In cases of severe ...
Gram-negative bacteria
The drugs that specifically target gram-negative organisms include aminoglycosides, monobactams (aztreonam) and ciprofloxacin. ... Other classes of drugs that have gram negative spectrum include cephalosporins, monobactams (aztreonam), aminoglycosides, ...
Haverhill fever
They are: cephalosporins, carbapenems, aztreonam, clindamycin, erythromycin, nitrofurantoin, bacitracin, doxycycline, ...
Bronchiectasis
Options for inhaled antibiotics include aerosolized tobramycin, inhaled ciprofloxacin, aerosolized aztreonam, and aerosolized ...
Cardiobacterium valvarum
... and aztreonam. Current clinical guidelines recommend that C.valvarum infection be treated with a 4-week course of ceftriaxone ...
Beta-lactamase
Aztreonam is stable to the metallo-β-lactamases, but many IMP and VIM producers are resistant, owing to other mechanisms. ... These cephalosporins include cefotaxime, ceftriaxone, and ceftazidime, as well as the oxyimino-monobactam aztreonam. Thus ESBLs ... and aztreonam, even if it is tested (in vitro) as susceptible.[citation needed] Associated resistance to aminoglycosides and ... as well as the oxyimino-monobactam aztreonam), but not 7-alpha-methoxy-cephalosporins (cephamycins; in other words, cefoxitin ...
Ceftazidime
... shares the same variable R-group side chain with aztreonam, a monobactam antibiotic; the two drugs share a similar ...
Cerebral shunt
Meropenem and aztreonam are additional antibiotic options that are effective against gram-negative bacterial infections. To ...
Enterococcus faecalis
E. faecalis is usually resistant to many commonly used antimicrobial agents (aminoglycosides, aztreonam and quinolones. The ...
Claire Wainwright
Wainwright CE, Quittner AL, Geller DE, Nakamura C, Wooldridge JL, Gibson RL, Lewis S, Montgomery AB (July 2011). "Aztreonam for ...
Cardiobacterium hominis
... and aztreonam. C. hominis is often resistant to erythromycin. Since cefotaxime use may be not appropriate for C. hominis ...
Gilead Sciences
Corus was developing aztreonam lysine for the treatment of patients with cystic fibrosis who are infected with Pseudomonas ...
Richard Sykes (microbiologist)
By modifying the amide side chain and including a ceftazidime side chain, he produced aztreonam, the first monocyclic β-lactam ... Subsequently, he was recruited by the Squibb Institute, in the United States, where he then developed aztreonam, the first ...
Raman spectroscopy
For example, the drug Cayston (aztreonam), marketed by Gilead Sciences for cystic fibrosis, can be identified and characterized ...
Bordetella avium
Resistance has been elucidated to aztreonam, ampicillin, tetracycline, cephalosporins, penicillins, sulbactams, sulfonamides, ...
Chromobacterium violaceum
C. violaceum produces a number of natural antibiotics: Aztreonam is a monobactam antibiotic that is active against gram- ... For theoretical reasons, infection would not be expected to respond to penicillins, cephalosporins, or aztreonam, although ...
Karen Bush
While at The Squibb Institute, Bush was part of the team that discovered Aztreonam and rose from a Research Investigator ... or aztreonam-avibactam combinations. Antimicrob Agents Chemother, August 2017 61:e00389-17. Bush, K., P. Courvalin, G. Dantas, ... or Aztreonam-Avibactam". Antimicrobial Agents and Chemotherapy. 61 (8): e00389-17, e00389-17. doi:10.1128/AAC.00389-17. ISSN ... aztreonam, piperacillin-tazobactam, levofloxacin, doripenem and ceftobiprole). As a Professor, Bush has continued to lead ...
Ceftaroline fosamil
Vancomycin plus Aztreonam in Complicated Skin and Skin Structure Infections (cSSSI). 2008 Interscience Conference on ... The CANVAS I and CANVAS II trials evaluated ceftaroline monotherapy versus vancomycin plus aztreonam in adult subjects with ... skin and skin structure infections with reported non-inferior efficacy against MRSA compared to vancomycin and aztreonam. In ...
Pathogenic Escherichia coli
... aztreonam, trimethoprim-sulfamethoxazole, ciprofloxacin, nitrofurantoin and the aminoglycosides. Antibiotic resistance is a ...
Jeffrey Feltner
... as Feltner's AIDS had been getting progressively worse despite treatment with Aztreonam. As a result of this, he died on March ...
Burkholderia cepacia complex
... evidence is insufficient about the effectiveness of long-term antibiotic treatment with continuous inhaled aztreonam lysine ( ...
List of antibiotics
Polymyxin B Aztreonam (monobactam) Aminoglycosides Antibiotics that cover vancomycin-resistant Enterococcus (VRE): Linezolid ...
List of MeSH codes (D03)
... aztreonam MeSH D03.383.411.500 - moxalactam MeSH D03.383.517.200 - carboxin MeSH D03.383.533.249 - benzoxazines MeSH D03.383. ...
Pseudomonas aeruginosa
carbapenems (meropenem, imipenem, doripenem, but not ertapenem) polymyxins (polymyxin B and colistin) monobactams (aztreonam) ...
Tigecycline
... successfully completed phase III trials in which it was at least equal to intravenous vancomycin and aztreonam to ...
Delafloxacin
... was approved by the FDA in June 2017, after it was noninferior to vancomycin plus aztreonam in two trials on 1042 ...
Enterobacter cloacae
... among Escherichia coli and Klebsiella isolates with hidden resistance to expanded-spectrum cephalosporins and aztreonam? ...
Aztreonam Lysine for Inhalation
How does inhaled aztreonam compare with IV aztreonam? ... Aztreonam Lysine for Inhalation. New Formulation of an Old ... In a Phase I trial, inhaled aztreonam was shown to be noninferior to the original i.v. formulation, aztreonam arginine, with ... Interestingly, i.v. aztreonam exhibits little to no "inoculum effect" in P. aeruginosa infections.[17,22,24] Negligible gram- ... Synergy has been observed when aztreonam is coadministered with an aminoglycoside in P. aeruginosa infections, likely due to ...
Aztreonam Injection: MedlinePlus Drug Information
Aztreonam Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... You may receive aztreonam injection in a hospital, or you may use the medication at home. If you will be using aztreonam ... Use aztreonam injection until you finish the prescription, even if you feel better. If you stop using aztreonam injection too ... Before using aztreonam injection,. *tell your doctor and pharmacist if you are allergic to aztreonam, cephalosporins such as ...
Reducing Aztreonam Use - AU Option Case Example | NHSN | CDC
As of the 1st Quarter of 2019, the use of aztreonam at the facility has decreased to approximately 10 antimicrobial days per ... A Veterans Affairs (VA) hospital evaluated use of aztreonam by analyzing NHSN Antimicrobial Use (AU) Option data pulled monthly ... Decreasing Aztreonam Use in a Veterans Affairs Hospital. ... the P&T Antimicrobial Subcommittee identified aztreonam as an ... The educational tool also provided guidance for recommending alternatives to aztreonam based on this risk. The facility decided ...
Aztreonam - Wikipedia
Aztreonam exhibits cross-sensitivity with ceftazidime due to a similar side chain. Aztreonam is similar in action to penicillin ... Aztreonam is bactericidal, but less so than some of the cephalosporins.[medical citation needed] "Aztreonam". The American ... Aztreonam inhibits cell wall synthesis by blocking peptidoglycan crosslinking to cause bacterial death. Aztreonam was approved ... In these circumstances aztreonam is combined with avibactam (ceftazidime/avibactam). The combination of aztreonam and avibactam ...
Aztreonam (Intravenous Route, Injection Route) Side Effects - Mayo Clinic
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
DailyMed - AZTREONAM injection, powder, lyophilized, for solution
Aztreonam is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Aztreonam has activity in the ... All of the above doses of aztreonam for injection result in average urine levels of aztreonam that exceed the MIC90 for the ... Unchanged aztreonam and the inactive beta-lactam ring hydrolysis product of aztreonam were present in feces and urine. ... Aztreonam for Injection, USP contains the active ingredient aztreonam, a monobactam. It was originally isolated from ...
Azactam (aztreonam) dosing, indications, interactions, adverse effects, and more
Quality of Life Questionnaire for Bronchiectasis Tested Alongside Aztreonam | RT
... use of Respiratory Domain of the Quality of Life Questionnaire-Bronchiectasis in evaluating patients taking inhaled aztreonam. ... Quality of Life Questionnaire for Bronchiectasis Tested Alongside Aztreonam. Jan 15, 2015 , Cystic fibrosis, Testing , ... in evaluating patients taking inhaled aztreonam, a drug used to treat cystic fibrosis lung infections. ...
Aztreonam | Genelabs.com
Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from Chromobacterium violaceum. Aztreonam ... Aztreonam maintains its antimicrobial activity over a pH range of 6 to 8 in vitro, as well as in the presence of human serum ... In healthy subjects, aztreonam is excreted in the urine about equally by active tubular secretion and glomerular filtration. ... The serum half-life of aztreonam averaged 1.7 hours (1.5 to 2.0) in subjects with normal renal function, independent of the ...
Generic AZTREONAM INN entry, drug patent expiration information and freedom to operate
AZTREONAM INN patents, expiration and generic drug launch ... Aztreonam - Generic Drug Details. ⮩ Send this page by email. ✉ ... AZTREONAM. aztreonam. INJECTABLE;INJECTION. 206517-001. Nov 8, 2021. AP. RX. No. No. See Plans and Pricing. See Plans and ... AZTREONAM. aztreonam. INJECTABLE;INJECTION. 065439-002. Jun 18, 2010. AP. RX. No. No. See Plans and Pricing. See Plans and ... AZTREONAM. aztreonam. INJECTABLE;INJECTION. 065286-001. Mar 23, 2011. DISCN. No. No. See Plans and Pricing. See Plans and ...
FAQs | CAYSTON® (aztreonam for inhalation solution)
Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. ... Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. ... Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. ... Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. ...
Acute Pyelonephritis Medication: Sulfonamides, Fluoroquinolones, Cephalosporins, Second Generation, Cephalosporins, Third...
Unlike the penicillins and cephalosporins, aztreonam is a monobactam. Monobactams such as aztreonam are bactericidal; however, ... Aztreonam is approved for the treatment of complicated and uncomplicated cystitis. It is approved for the treatment of ... Aztreonam lacks cross-sensitivity with beta-lactam antibiotics and may be used in patients allergic to penicillins or ...
Aztreonam
-
Beta-Lactamase inhibitor
Serratia Medication: Antibiotics
Table 2 - Waterborne Elizabethkingia meningoseptica in Adult Critical Care - Volume 22, Number 1-January 2016 - Emerging...
aztreonam: Uses, Taking, Side Effects, Warnings - Medicine.com
Learn about aztreonam: What is it used for, what you need to know before taking, important warnings and safety info, how to ... Before taking aztreonam, tell your doctor:. *If you are allergic to aztreonam; any part of this medicine; or any other drugs, ... How is aztreonam best taken?. Use aztreonam as ordered by your doctor. Read all information given to you. Follow all ... What is aztreonam used for?. *Aztreonam is used in some people with cystic fibrosis to make breathing better. ...
AZACTAM® (aztreonam injection) || Infection Management
AZACTAM® (aztreonam for injection, USP) is contraindicated in patients with known hypersensitivity to aztreonam or any other ... AZACTAM® (aztreonam for injection, USP) is contraindicated in patients with known hypersensitivity to aztreonam or any other ... Aztreonam crosses the placenta and enters the fetal circulation. Aztreonam is excreted in human milk so consideration should be ... AZACTAM® (aztreonam for injection, USP) should be used only to treat or prevent infections that are proven or strongly ...
Prescription drug CAYSTON (aztreonam) - DrugFinder.ca
Δίσκοι Αντιβιοτικών Aztreonam ATM 30µg - Bioprom
"Δισκοι ευαισθησίας αντιβιωτικών Aztreonam ATM 30 µg της LIOFILCHEM Ιταλίας Συσκευασία 50 δίσκων ... Δίσκοι Αντιβιοτικών Aztreonam ATM 30µg. 2,90€. EXW. Δισκοι ευαισθησίας αντιβιωτικών Aztreonam ATM 30 µg της LIOFILCHEM Ιταλίας ... HomeConsumablesΔΙΣΚΟΙ ΑΝΤΙΒΙΩΤΙΚΩΝ Δίσκοι Αντιβιοτικών Aztreonam ATM 30µg. Previous product Δίσκοι Αντιβιοτικών Azithromycin ... Δίσκοι αντιβιωτικών κατάλληλοι για την ανίχνευση ευαισθησίας (αντιβιόγραμμα) στην ουσία Aztreonam ATM. ...
AZTREONAM Other
(aztreonam for injection, USP)
| Pfizer Medical Information - US
... aztreonam for injection should be used only to treat or prevent infections that are proven or strongly ... Rx only To reduce the development of drug-resistant bacteria and maintain the effectiveness of aztreonam for injection and ... Aztreonam for Injection, USP contains the active ingredient aztreonam, a monobactam. It was originally isolated from ... AZTREONAM Quick Finder *. Pfizer samples (for eligible HCPs) Requests for samples of prescription medications can be made by ...
AZTREONAM or AZACTAM - Find The Best Price Near You | WellRx
Find the best AZTREONAM or AZACTAM prices near you now with our cost comparison tool and start saving today. ... How much does AZTREONAM or AZACTAM cost near you? ... aztreonam has been added to your Medicine Chest. View My ... AZTREONAM/Azactam (AZ tree oh nam) is an antibiotic. It treats some infections caused by bacteria. It will not work for colds, ...
No Difference in Adverse Events Between Delafloxacin or Vancomycin/Aztreonam in ABSSSI - Infectious Disease Advisor
Incidence of AEs with delafloxacin was comparable to the combination regimen of vancomycin/aztreonam across 2 phase 3 ... No Difference in Adverse Events Between Delafloxacin or Vancomycin/Aztreonam in ABSSSI. Brandon May ... Overall, gastrointestinal AEs were the most common: 17% in the delafloxacin group vs 13% in the vancomycin/aztreonam group. ... Comparison of safety profile of delafloxacin (DLX) versus vancomycin/aztreonam (VAN/AZ) in thetreatment of patients (pts) with ...
Aztreonam compared to chloramphenicol in the treatment of enteric fevers<...
... were treated in an open randomized parallel study with either aztreonam or chloramphenicol. Aztreonam was given intramuscularly ... were treated in an open randomized parallel study with either aztreonam or chloramphenicol. Aztreonam was given intramuscularly ... were treated in an open randomized parallel study with either aztreonam or chloramphenicol. Aztreonam was given intramuscularly ... were treated in an open randomized parallel study with either aztreonam or chloramphenicol. Aztreonam was given intramuscularly ...
Humatin (paromomycin) dosing, indications, interactions, adverse effects, and more
Aztreonam for Injection Market Size, Share, Trends, Regional Outlook, and Forecast by 2028 - Bloggers Baba
10.1 Aztreonam for Injection Industry Value Chain. 10.2 Aztreonam for Injection Upstream Market. 10.3 Aztreonam for Injection ... 7.12.3 AZACTAM Aztreonam for Injection Major Product Offerings. 7.12.4 AZACTAM Aztreonam for Injection Sales and Revenue in ... 7.13.3 Globalstar Aztreonam for Injection Major Product Offerings. 7.13.4 Globalstar Aztreonam for Injection Sales and Revenue ... 8.2 Aztreonam for Injection Production Capacity of Key Manufacturers in Global Market. 8.3 Global Aztreonam for Injection ...
Our Pfizer Products Hold the Cure | Pfizer
In this section find an overview of our Pfizer Products and search for information on our most popular Pfizer products. Our products are the results of 1500 scientists overseeing more than 500,000 lab tests and over 36 clinical trials before the first prescription. Our Pfizer products hold the cure.
Manufacturers' alerts - The Society of Hospital Pharmacists of Australia
AZACTAM (aztreonam) 1g Powder for injection shortage. 11 May 2018. Bristol Myers Squibb Australia advises that due to a ... BMS recommends all health care providers prioritise aztreonam for patients they feel are in the greatest need with no other ... manufacturing issue at the active substance manufacturing plance there is a shortage of AZACTAM (aztreonam) 1g powder for ...
Haloperidol Monograph for Professionals - Drugs.com
AzactamMeropenemCephalosporinsAmikacinAntibioticsCefotaximePseudomonasInjectionMonobactamCaystonPlus aztreonamGram-negativeColistinIsolatesTobramycinCeftazidime and aztreonamDrugsCystic fibrosisAntibioticChloramphenicolTigecyclineAvibactamGiven intramuscularlyAntimicrobial ActivityInhalation solutionAllergicInfectionsIntravenouslyPenicillin bindingResistanceBacterialHypersensitivity reactionsBacteriaPatientsAeruginosaLinezolidKlebsiellaLungUrineExhibits
Azactam7
- Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. (wikipedia.org)
- Aztreonam is poorly absorbed when given orally, so it must be administered as an intravenous or intramuscular injection (trade name Azactam), or inhaled (trade name Cayston) using an ultrasonic nebulizer. (wikipedia.org)
- AZACTAM ® (aztreonam for injection, USP) delivers proven efficacy in the management of certain Gram-negative infections. (bmscustomerconnect.com)
- AZACTAM ® (aztreonam for injection, USP) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. (bmscustomerconnect.com)
- AZTREONAM/Azactam (AZ tree oh nam) is an antibiotic. (wellrx.com)
- Learn moreFeedbackSee morePeople also askALLEnterocolitis TreatmentMicroscopic colitis TreatmentColic TreatmentDiversion colitis TreatmentWhat is the best medicine for E coli?What is the best medicine for E coli?coli?Antibiotics.Trimethoprim/sulfamethoxazole (Bactrim, Bactrim DS, Septra DS, Sulfatrim)Ciprofloxacin (Cipro)Levofloxacin (Levaquin)Amoxicillin (Moxatag)Aztreonam (Azactam)What is the best treatment of Escherichia coli? (family-medical.net)
- For patients allergic to penicillin, a respiratory fluoroquinolone plus aztreonam (Azactam) are recommended. (usmlestep3blog.com)
Meropenem3
- Extended incubation of 48 h showed an increase in phenotypic resistance for all antimicrobials, ranging from 6.5% for aztreonam and meropenem to 48% for cefepime. (researchgate.net)
- Over a 6-month period, a retrospective chart review of meropenem , aztreonam, and linezolid - commonly identified as alternative treatments for individuals with beta-lactam allergy - was conducted at a county medical center. (clinicaladvisor.com)
- It has a synergistic effect when combined with amikacin, tazobactam, meropenem and aztreonam and has low potential for resistance development and the favorable safety and tolerability profile in clinical trials. (medchrome.com)
Cephalosporins6
- Because of the unfused beta-lactam ring there is somewhat lower cross-reactivity between aztreonam and many other beta-lactam antibiotics, and it may be safe to administer aztreonam to many patients with hypersensitivity (allergies) to penicillins and nearly all cephalosporins. (wikipedia.org)
- ESBL is a resistance mechanism in which the beta-lactam ring of antibiotics such as penicillins, cephalosporins, and aztreonam is hydrolyzed, inactivating the antibiotic. (hindawi.com)
- 65 years, or recent history of UTI) are treated with a 7- to 14-day course of antibiotics (eg, levofloxacin, third-generation cephalosporins, or aztreonam). (medscape.com)
- Detection of ESBL producers' poses a special challenge for clinical microbiology laboratories, although ESBL producing pathogens are able to hydrolyze extended-spectrum penicillins, cephalosporins, and aztreonam, the minimum inhibitory concentrations (MIC) of some and perhaps even all of these agents may be within the susceptible range. (scirp.org)
- Hydrolyzes carbapenems, penicillins, cephalosporins and aztreonam with varying efficiency. (genebiosystems.com)
- KPC-positive strains are typically resistant to the penicillins, extended-spectrum cephalosporins, and aztreonam, but the MICs of these drugs and of the carbapenems are reduced in the presence of clavulanic acid due to enzyme inhibition [ 2 ]. (biomedcentral.com)
Amikacin3
- Aztreonam and amikacin were intravenously administered at doses of 2 g/day and 800 mg/day, respectively. (elsevier.com)
- In conclusion, the combination therapy between aztreonam and amikacin, or ciprofloxacin may be clinically useful for severe infections of MDRP in compromised hosts. (elsevier.com)
- Newer nebulized (amikacin, aztreonam, colistin, and fosfomycin with tobramycin) and dry powder (ciprofloxacin, colistin, and tobramycin) forms have been developed that may benefit these patients. (bronchiectasisnewstoday.com)
Antibiotics10
- Aztreonam is in a class of medications called monobactam antibiotics. (medlineplus.gov)
- Antibiotics such as aztreonam injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
- If you stop using aztreonam injection too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
- There is a much lower risk of cross-sensitivity between aztreonam and other beta-lactam antibiotics than within other beta-lactam antibiotics. (wikipedia.org)
- Both animal and human data suggest that aztreonam for injection is rarely cross-reactive with other beta-lactam antibiotics and weakly immunogenic. (pfizermedicalinformation.com)
- In the E. coli host, the plasmid expressed a high level of AmpC-like ß-lactamase designated KU and conferred the E. coli transformants to become resistant to ß-lactam antibiotics, such as aztreonam, cefuroxime, cefotaxime and ceftazidime. (avhandlingar.se)
- Aztreonam belongs to the class of medications called antibiotics . (rxhealthmed.ca)
- SAFODEX 50 DRY SYRUP should be avoided if you are allergic to cefpodoxime or to the cephalosporin group of antibiotics (such as cefuroxime, cefixime) or if you had experienced immediate or severe hypersensitivity reaction (anaphylaxis) to penicillin or other beta-lactam antibiotics (such as aztreonam). (netmeds.com)
- This new generation of antibiotics includes aztreonam (better known as Cayston™), which acts directly against Pseudomonas . (vivreaveclafibrosekystique.com)
- pelargonii (Xcp) in plant material, two new semi-selective media were developed, the Tween-cellobiose-medium with the antibiotics Cephalexin, 5-Fluorouracil, Tobramycin and Cycloheximid and the MD5A-medium with cellobiose, glutamic acid, methionine and the antibiotics Cephalexin, Bacitracin and Aztreonam, and with bromothymol blue. (uni-goettingen.de)
Cefotaxime1
- Extended-spectrum beta-lactamases (ESBLs) efficiently hydrolyze extended-spectrum beta-lactams such as cefotaxime, ceftriaxone, ceftazidime, and aztreonam. (elsevier.com)
Pseudomonas8
- [ 17 , 22 ] I.V. aztreonam maintains stability to hydrolysis in the presence of many chromosomally mediated and plasmid-mediated β-lactamases, such as the Pseudomonas -specific enzymes, which appear to be most prevalent in P. aeruginosa isolates. (medscape.com)
- In late 2016, the P&T Antimicrobial Subcommittee identified aztreonam as an area where inappropriate prescribing was likely high throughout the facility given that this antimicrobial has less than optimal susceptibility to Pseudomonas aeruginosa on the facility's antibiogram. (cdc.gov)
- Aztreonam has strong activity against susceptible Gram-negative bacteria, including Pseudomonas aeruginosa. (wikipedia.org)
- Acinetobacter anitratus, Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis are generally susceptible to aztreonam, while some staphylococci, Staphylococcus aureus, Staphylococcus haemolyticus and Xanthomonas maltophilia are resistant to it. (wikipedia.org)
- Aztreonam exhibits potent and specific activity in vitro against a wide spectrum of gram-negative aerobic pathogens including Pseudomonas aeruginosa . (genelabs.com)
- The team discovered this ability after combining EGCG with aztreonam, an antibiotic commonly used to fight off infections caused by Pseudomonas aeruginosa . (naturalnews.com)
- To determine the activity of murepavadin in comparison with tobramycin, colistin and aztreonam, against cystic fibrosis (CF) Pseudomonas aeruginosa isolates growing in biofilms. (physiciansweekly.com)
- Urine culture shows pseudomonas aeruginosa bacteria Aztreonam, cefuroxime and cefuroxime shows resistant zone size 6 mm And ultra sound kub shows mild diffuse urinary bladder wall thickening Previously VUR GRADE 5 REFLUX operation done Please suggest complete prevention of recurrent UTI Do you have a fever? (lybrate.com)
Injection22
- Aztreonam injection is used to treat certain infections that are caused by bacteria, including respiratory tract (including pneumonia and bronchitis), urinary tract, blood, skin, gynecological, and abdominal (stomach area) infections, that are caused by bacteria. (medlineplus.gov)
- Aztreonam injection also may be used before, during, and sometimes for a brief period after surgery in order to prevent the patient from getting an infection. (medlineplus.gov)
- Aztreonam injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). (medlineplus.gov)
- How often you receive aztreonam injection and the length of your treatment depends on the type of infection you have and how your body responds to the medication. (medlineplus.gov)
- Your doctor will tell you how long to use aztreonam injection. (medlineplus.gov)
- You may receive aztreonam injection in a hospital, or you may use the medication at home. (medlineplus.gov)
- If you will be using aztreonam injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
- You should begin to feel better during the first few days of treatment with aztreonam injection. (medlineplus.gov)
- Use aztreonam injection until you finish the prescription, even if you feel better. (medlineplus.gov)
- Aztreonam injection is also sometimes used to treat patients who have fever and are at high risk for infection because they have a low number of white blood cell. (medlineplus.gov)
- If you become pregnant while using aztreonam injection, call your doctor. (medlineplus.gov)
- Aztreonam injection may cause side effects. (medlineplus.gov)
- To reduce the development of drug-resistant bacteria and maintain the effectiveness of aztreonam for injection and other antibacterial drugs, aztreonam for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
- Aztreonam for Injection, USP contains the active ingredient aztreonam, a monobactam. (nih.gov)
- Aztreonam for Injection is a sterile, nonpyrogenic, sodium-free, lyophilized, off-white to slightly yellowish solid, containing approximately 780 mg arginine per gram of aztreonam. (nih.gov)
- After identical single intravenous or intramuscular doses of aztreonam for injection, the serum concentrations of aztreonam are comparable at 1 hour (1.5 hours from start of intravenous infusion) with similar slopes of serum concentrations thereafter. (nih.gov)
- All of the above doses of aztreonam for injection result in average urine levels of aztreonam that exceed the MIC 90 for the same pathogens for up to 12 hours. (nih.gov)
- To reduce the development of drug-resistant bacteria and maintain the effectiveness of Aztreonam for Injection, USP and other antibacterial drugs, aztreonam for injection should be used only to treat or. (pfizermedicalinformation.com)
- Aztreonam for Injection may be administered intravenously or by intramuscular injection. (pfizermedicalinformation.com)
- Aztreonam for Injection Market Status and Trend Report 2016-2030 offers a comprehensive analysis on Aztreonam for Injection industry, standing on the readers? (bloggersbaba.com)
- falling business confidence, growing panic among the population, and uncertainty about future.This report also analyses the impact of Coronavirus COVID-19 on the Aztreonam for Injection industry. (bloggersbaba.com)
- Leading Wholesale Distributor of guficol plus injection, ertafic 1gm inj, mnem 1000mg, aztreonam 1gm injection, bihepenem injection and guficol from Pune. (janwamedical.com)
Monobactam2
- Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from Chromobacterium violaceum . (genelabs.com)
- Aztreonam, a synthetic monobactam originally isolated as SQ 26,180 from Chromobacterium violaceum, is the first clinically used monobactam. (kegg.jp)
Cayston1
- Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. (cayston.com)
Plus aztreonam4
- Ceftaroline fosamil ( ZINFORO ® ) 600 mg q12h demonstrated comparable efficacy versus vancomycin plus aztreonam 1 g q12h in terms of clinical cure rates. (pfizerpro.in)
- Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection. (pfizerpro.in)
- Dryden M, Zhang Y, Wilson D, Iaconis JP, Gonzalez J. A Phase III, randomized, controlled, non-inferiority trial of ceftaroline fosamil 600 mg every 8 h versus vancomycin plus aztreonam in patients with complicated skin and soft tissue infection with systemic inflammatory response or underlying comorbidities. (pfizerpro.in)
- Approval of the updated label was based on data from two studies comparing patients with ABSSSI treated with ceftaroline fosamil monotherapy or vancomycin plus aztreonam , the company said. (medscape.com)
Gram-negative1
- The activity of inhaled aztreonam extends broadly across susceptible gram-negative aerobic bacteria, including P. aeruginosa . (medscape.com)
Colistin1
- All 31(100%) P. aeruginosa isolates were sensitive to colistin and polymixin B, while 30 (96.8%) isolates showed sensitivity to piperacillin-tazobactam, cefoperazone-sulbactam and aztreonam. (jacmjournal.org)
Isolates2
- The combination of aztreonam and avibactam has demonstrated to be active against 80% of MBL isolates reaching a clinical infection resolution in 80% of MBL-infected patients. (wikipedia.org)
- All isolates were resistant to aztreonam and two isolates were resistant to tigecycline. (who.int)
Tobramycin1
- Staphylococcus aureus 8 - >128 μg/ml Staphylococcus epidermidis 8 - 32 μg/ml Streptococcus pyogenes 8 - ≥128 μg/ml Synergism between aztreonam and arbekacin or tobramycin against P. aeruginosa has been suggested. (wikipedia.org)
Ceftazidime and aztreonam1
- Aztreonam can be safely used in patients with a penicillin or cephalosporin allergy (except for patients with a ceftazidime allergy as ceftazidime and aztreonam share a similar side chain). (wikipedia.org)
Drugs2
- You must check to make sure that it is safe for you to take aztreonam with all of your drugs and health problems. (medicine.com)
- Use aztreonam after other breathed in drugs. (medicine.com)
Cystic fibrosis2
- Gilead Sciences has investigated the use of the Respiratory Domain of the Quality of Life Questionnaire-Bronchiectasis (QOL-B) in evaluating patients taking inhaled aztreonam, a drug used to treat cystic fibrosis lung infections. (rtmagazine.com)
- Aztreonam is used in some people with cystic fibrosis to make breathing better. (medicine.com)
Antibiotic1
- Aztreonam-Avibactam Susceptibility Testing Program for Metallo-Beta-Lactamase-Producing Enterobacterales in the Antibiotic Resistance Laboratory Network, March 2019 to December 2020. (cdc.gov)
Chloramphenicol2
- Fifty-seven patients, twenty-six males and thirty-one females, aged 6 to 50 years (mean 12.6 years) with proven Salmonella typhi or S. paratyphi A septicaemia, were treated in an open randomized parallel study with either aztreonam or chloramphenicol. (unthsc.edu)
- Only one patient on aztreonam relapsed following treatment, whereas three patients relapsed after chloramphenicol treatment. (unthsc.edu)
Tigecycline1
- Additional data were also presented comparing tigecycline with vancomycin/aztreonam in the treatment of cSSI. (drugtopics.com)
Avibactam2
- In these circumstances aztreonam is combined with avibactam (ceftazidime/avibactam). (wikipedia.org)
- Assessing the in vitro impact of ceftazidime on aztreonam/avibactam susceptibility testing for highly resistant MBL-producing Enterobacterales. (cdc.gov)
Given intramuscularly2
- When aztreonam is given intramuscularly, it is injected into the muscles of the buttocks or thighs. (medlineplus.gov)
- Aztreonam was given intramuscularly at a level of 50 to 80 mg/kg body weight per dose every 8 h for 7 days to thirty patients. (unthsc.edu)
Antimicrobial Activity1
- Aztreonam maintains its antimicrobial activity over a pH range of 6 to 8 in vitro, as well as in the presence of human serum and under anaerobic conditions. (genelabs.com)
Inhalation solution1
- Each dose of aztreonam for inhalation solution consists of a 2 mL vial of sterile, lyophilized powder that contains 75 mg of aztreonam. (rxhealthmed.ca)
Allergic1
- Those who are allergic to other β-lactam have a low rate of allergy to aztreonam. (wikipedia.org)
Infections3
- Interestingly, i.v. aztreonam exhibits little to no "inoculum effect" in P. aeruginosa infections. (medscape.com)
- Synergy has been observed when aztreonam is coadministered with an aminoglycoside in P. aeruginosa infections, likely due to complementary mechanisms of action. (medscape.com)
- Aztreonam use has been recently reconsidered for human infections sustained by metallo-beta-lactamase (MBL)-producing Gram-negative bacteria. (wikipedia.org)
Intravenously1
- When aztreonam is injected intravenously, it is usually infused (injected slowly) over a period of 20 minutes to 1 hour. (medlineplus.gov)
Penicillin binding1
- The bactericidal action of aztreonam results from the inhibition of bacterial cell wall synthesis due to a high affinity of aztreonam for penicillin binding protein 3 (PBP3). (genelabs.com)
Resistance3
- and Streptococcus pyogenes have developed resistance to aztreonam to varying degrees. (wikipedia.org)
- This particular variety -- the NDM-1s have varied slightly in their resistance patterns -- was susceptible to only a single drug, aztreonam. (wired.com)
- Resistance to amoxicillin-clavulanic acid (6.3%) and aztreonam (5%) was less commonly detected. (allenpress.com)
Bacterial3
- Aztreonam inhibits cell wall synthesis by blocking peptidoglycan crosslinking to cause bacterial death. (wikipedia.org)
- By binding to PBP3, aztreonam inhibits the third and last stage of bacterial cell wall synthesis. (genelabs.com)
- SAN DIEGO - Delafloxacin ( Baxdela™ , Melinta Therapeutics), had similar adverse event (AE) profiles when compared with vancomycin/aztreonam as treatment options in patients with acute bacterial skin and skin structure infection (ABSSSI), according to findings from 2 multicenter double-blind, randomized phase 3 trials presented at IDWeek 2017 . (infectiousdiseaseadvisor.com)
Hypersensitivity reactions1
- Treatment with aztreonam can result in hypersensitivity reactions. (pfizermedicalinformation.com)
Bacteria1
- Pirazmonam is more active than aztreonam against nonfermentative gram-negative bacteria. (semanticscholar.org)
Patients7
- When aztreonam pharmacokinetics were assessed for adult and pediatric patients, they were found to be comparable (down to 9 months old). (nih.gov)
- In elderly patients, the mean serum half-life of aztreonam increased and the renal clearance decreased, consistent with the age-related decrease in creatinine clearance. (nih.gov)
- In elderly patients and in patients with impaired renal function, the mean serum half-life of aztreonam increased (4.7 to 6 hours and 2.1 hours, respectively). (genelabs.com)
- This preparation is contraindicated in patients with known hypersensitivity to aztreonam or any other component in the formulation. (pfizermedicalinformation.com)
- Investigators evaluated outcomes in patients with ABSSSI who received delafloxacin 300 mg IV every 12 hours, or delafloxacin 300 mg IV every 12 hours for 3 days with a mandatory blinded switch to oral delafloxacin 450 mg every 12 hours, or vancomycin 15 mg/kg IV (actual body weight) with aztreonam between 5 to 14 days. (infectiousdiseaseadvisor.com)
- In comparison with vancomycin/aztreonam, no increase in fluoroquinolone-associated events was observed in the delafloxacin patients. (infectiousdiseaseadvisor.com)
- En Égypte, des isolats prélevés sur les tubulures d'appareils d'aspiration et de respiration artificielle (A8) et sur les cuvettes (A7) étaient liés à ceux prélevés chez les patients ayant ces antibiotypes. (who.int)
Aeruginosa1
- RÉSUMÉ La présente étude visait à caractériser des isolats de P. aeruginosa dans deux unités de soins intensifs en Arabie saoudite et en Égypte. (who.int)
Linezolid1
- The patient was placed on Linezolid, Clindamycin, and Aztreonam. (faoj.org)
Klebsiella1
- [ 23 ] I.V. aztreonam is known to have increased minimum inhibitory concentration (MIC) values in the presence of high inoculum of certain β-lactamase-rich gram-negative organisms, including Klebsiella species. (medscape.com)
Lung3
- Lung function has gotten worse in some people after taking aztreonam for 28 days. (medicine.com)
- Have your lung function checked while taking aztreonam. (medicine.com)
- If you are using several medications, use them in the order of bronchodilator, mucolytic (medication to loosen the mucus in the lung), and aztreonam. (rxhealthmed.ca)
Urine1
- In healthy subjects, aztreonam is excreted in the urine about equally by active tubular secretion and glomerular filtration. (genelabs.com)
Exhibits1
- Aztreonam exhibits cross-sensitivity with ceftazidime due to a similar side chain. (wikipedia.org)