Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.
Substances that reduce the growth or reproduction of BACTERIA.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Infections with bacteria of the genus PSEUDOMONAS.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
Gram-negative gas-producing rods found in feces of humans and other animals, sewage, soil, water, and dairy products.
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
A semisynthetic ampicillin-derived acylureido penicillin.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Infections with bacteria of the family ENTEROBACTERIACEAE.
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Semisynthetic broad-spectrum cephalosporin.
Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
Skin diseases caused by bacteria.
Infections with bacteria of the genus KLEBSIELLA.
A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
A genus of gram-negative, rod-shaped enterobacteria that can use citrate as the sole source of carbon.
Bicyclic bridged compounds that contain a nitrogen which has three bonds. The nomenclature indicates the number of atoms in each path around the rings, such as [2.2.2] for three equal length paths. Some members are TROPANES and BETA LACTAMS.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
An amidinopenicillanic acid derivative with broad spectrum antibacterial action.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria found in soil, water, food, and clinical specimens. It is a prominent opportunistic pathogen for hospitalized patients.
Non-susceptibility of an organism to the action of the cephalosporins.
A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
Infections with bacteria of the genus SERRATIA.
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in water, sewage, soil, meat, hospital environments, and on the skin and in the intestinal tract of man and animals as a commensal.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Infections by bacteria, general or unspecified.
An antibiotic derived from penicillin similar to CARBENICILLIN in action.
The rate dynamics in chemical or physical systems.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
Therapy with two or more separate preparations given for a combined effect.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in soil, fecal matter, and sewage. It is an opportunistic pathogen and causes cystitis and pyelonephritis.
A large group of aerobic bacteria which show up as pink (negative) when treated by the gram-staining method. This is because the cell walls of gram-negative bacteria are low in peptidoglycan and thus have low affinity for violet stain and high affinity for the pink dye safranine.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Bacteria which retain the crystal violet stain when treated by Gram's method.
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.
Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.
Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is frequently isolated from clinical specimens. Its most common site of infection is the urinary tract.
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
A serotype of SALMONELLA ENTERICA that causes mild PARATYPHOID FEVER in humans.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The process of cleaving a chemical compound by the addition of a molecule of water.
Enzyme which catalyzes the peptide cross-linking of nascent CELL WALL; PEPTIDOGLYCAN.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.
Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A broad-spectrum antimicrobial carboxyfluoroquinoline.
Enzymes that catalyze the transfer of hexose groups. EC 2.4.1.-.
A prolonged febrile illness commonly caused by several Paratyphi serotypes of SALMONELLA ENTERICA. It is similar to TYPHOID FEVER but less severe.
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
Proteins found in any species of bacterium.
A species of gram-negative, aerobic bacteria, commonly found in the clinical laboratory, and frequently resistant to common antibiotics.
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. There are ribosomal and non-ribosomal peptidyltransferases.
Infections with bacteria of the species ESCHERICHIA COLI.
Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
The action of a drug in promoting or enhancing the effectiveness of another drug.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. HAEMOPHILUS INFLUENZAE TYPE B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.
A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.
DNA elements that include the component genes and insertion site for a site-specific recombination system that enables them to capture mobile gene cassettes.
The chemical and physical integrity of a pharmaceutical product.
A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.
Any infection which a patient contracts in a health-care institution.
Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Simultaneous resistance to several structurally and functionally distinct drugs.
Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
Nonsusceptibility of an organism to the action of penicillins.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Injections made into a vein for therapeutic or experimental purposes.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Techniques used in studying bacteria.
The functional hereditary units of BACTERIA.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Elements of limited time intervals, contributing to particular results or situations.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Pathological processes of the KIDNEY or its component tissues.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

Effects of antibiotic therapy on Pseudomonas aeruginosa-induced lung injury in a rat model. (1/239)

The effect of antibiotics on the acute lung injury induced by virulent Pseudomonas aeruginosa PA103 was quantitatively analyzed in a rat model. Lung injury was induced by the instillation of PA103 directly into the right lower lobes of the lungs of anesthetized rats. The alveolar epithelial injury, extravascular lung water, and total plasma equivalents were measured as separate, independent parameters of acute lung injury. Four hours after the instillation of PA103, all the parameters were increased linearly depending on the dose of P. aeruginosa. Next, we examined the effects of intravenously administered antibiotics on the parameters of acute lung injury in D-galactosamine-sensitized rats. One hour after the rats received 10(7) CFU of PA103, an intravenous bolus injection of aztreonam (60 mg/kg) or imipenem-cilastatin (30 mg/kg) was administered. Despite an MIC indicating resistance, imipenem-cilastatin improved all the measurements of lung injury; in contrast, aztreonam, which had an MIC indicating sensitivity, did not improve any of the lung injury parameters. The antibiotics did not generate different quantities of plasma endotoxin; therefore, endotoxin did not appear to explain the differences in lung injury. This in vivo model is useful to quantitatively compare the efficacies of parenteral antibiotic administration on Pseudomonas airspace infections.  (+info)

In-vitro effects of a combination of antipseudomonal antibiotics against multi-drug resistant Pseudomonas aeruginosa. (2/239)

We evaluated the in-vitro effects of various combinations of five types of widely used antipseudomonal antibiotics (piperacillin, meropenem, ceftazidime, aztreonam and amikacin) against six Pseudomonas aeruginosa strains that were resistant to each of these antibiotics. Among two-drug combinations, the combinations of two beta-lactam antibiotics inhibited growth of one to three P. aeruginosa strains, while those of one beta-lactam antibiotic and amikacin inhibited growth of two to four strains. Among three-drug combinations, the combinations of three beta-lactam antibiotics inhibited growth of four to five strains, and those of two beta-lactam antibiotics and amikacin inhibited growth of five strains. These results suggest the potential usefulness of a combination of two beta-lactam antibiotics and amikacin or that of three beta-lactam antibiotics in treating multi-drug resistant P. aeruginosa infections.  (+info)

Detection and reporting of organisms producing extended-spectrum beta-lactamases: survey of laboratories in Connecticut. (3/239)

Extended-spectrum beta-lactamases (ESBLs) are enzymes produced in some gram-negative bacilli that mediate resistance to extended-spectrum cephalosporins and aztreonam. They are most common in Klebsiella spp. and Escherichia coli but are present in a variety of Enterobacteriaceae. Resistance mediated by these enzymes can be difficult to detect depending on the antimicrobial agents tested. AmpC beta-lactamases are related to the chromosomal enzymes of Enterobacter and Citrobacter spp. and also mediate resistance to extended-spectrum cephalosporins and aztreonam in addition to cephamycins, such as cefoxitin. Unlike ESBLs, however, AmpC beta-lactamases are not inhibited by clavulanic acid or other similar compounds. To assess the abilities of various antimicrobial susceptibility testing methods to detect ESBLs, we sent three ESBL-producing organisms, one AmpC-producing organism, and a control strain that was susceptible to extended-spectrum cephalosporins to 38 laboratories in Connecticut for testing. Eight (21.0%) of 38 labs failed to detect extended-spectrum cephalosporin or aztreonam resistance in any of the ESBL- or AmpC-producing isolates. Errors were encountered with both automated and disk diffusion methods. Conversely, seven (18.4%) labs categorized at least some of the four resistant isolates as potential ESBL producers and reported the results with the extended-spectrum cephalosporins and aztreonam as resistant as suggested by current National Committee for Clinical Laboratory Standards (NCCLS) guidelines. The percentage of laboratories that failed to detect resistance in the ESBL or AmpC isolates ranged from 23.7 to 31.6% depending on the type of enzyme present in the test organism. This survey suggests that many laboratories have difficulty detecting resistance in ESBL and AmpC-producing organisms and may be unaware of the NCCLS guidelines on modifying susceptibility testing reports for ESBL-producing strains.  (+info)

ampR gene mutations that greatly increase class C beta-lactamase activity in Enterobacter cloacae. (4/239)

The ampC and ampR genes of Enterobacter cloacae GN7471 were cloned into pMW218 to yield pKU403. Four mutant plasmids derived from pKU403 (pKU404, pKU405, pKU406, and pKU407) were isolated in an AmpD mutant of Escherichia coli ML4953 by selection with ceftazidime or aztreonam. The beta-lactamase activities expressed by pKU404, pKU405, pKU406, and pKU407 were about 450, 75, 160, and 160 times higher, respectively, than that expressed by the original plasmid, pKU403. These mutant plasmids all carried point mutations in the ampR gene. In pKU404 and pKU405, Asp-135 was changed to Asn and Val, respectively. In both pKU406 and pKU407, Arg-86 was changed to Cys. The ease of selection of AmpR mutations at a frequency of about 10(-6) in this study strongly suggests that derepressed strains, such as AmpD or AmpR mutants, could frequently emerge in the clinical setting.  (+info)

Penicillin binding protein 5 affects cell diameter, contour, and morphology of Escherichia coli. (5/239)

Although general physiological functions have been ascribed to the high-molecular-weight penicillin binding proteins (PBPs) of Escherichia coli, the low-molecular-weight PBPs have no well-defined biological roles. When we examined the morphology of a set of E. coli mutants lacking multiple PBPs, we observed that strains expressing active PBP 5 produced cells of normal shape, while mutants lacking PBP 5 produced cells with altered diameters, contours, and topological features. These morphological effects were visible in untreated cells, but the defects were exacerbated in cells forced to filament by inactivation of PBP 3 or FtsZ. After filamentation, cellular diameter varied erratically along the length of individual filaments and many filaments exhibited extensive branching. Also, in general, the mean diameter of cells lacking PBP 5 was significantly increased compared to that of cells from isogenic strains expressing active PBP 5. Expression of cloned PBP 5 reversed the effects observed in DeltadacA mutants. Although deletion of PBP 5 was required for these phenotypes, the absence of additional PBPs magnified the effects. The greatest morphological alterations required that at least three PBPs in addition to PBP 5 be deleted from a single strain. In the extreme cases in which six or seven PBPs were deleted from a single mutant, cells and cell filaments expressing PBP 5 retained a normal morphology but cells and filaments lacking PBP 5 were aberrant. In no case did mutation of another PBP produce the same drastic morphological effects. We conclude that among the low-molecular-weight PBPs, PBP 5 plays a principle role in determining cell diameter, surface uniformity, and overall topology of the peptidoglycan sacculus.  (+info)

Differential responses of Escherichia coli cells expressing cytoplasmic domain mutants of penicillin-binding protein 1b after impairment of penicillin-binding proteins 1a and 3. (6/239)

Penicillin-binding protein 1b (PBP1b) is the major high-molecular-weight PBP in Escherichia coli. Although it is coded by a single gene, it is usually found as a mixture of three isoforms which vary with regard to the length of their N-terminal cytoplasmic tail. We show here that although the cytoplasmic tail seems to play no role in the dimerization of PBP1b, as was originally suspected, only the full-length protein is able to protect the cells against lysis when both PBP1a and PBP3 are inhibited by antibiotics. This suggests a specific role for the full-length PBP1b in the multienzyme peptidoglycan-synthesizing complex that cannot be fulfilled by either PBP1a or the shorter PBP1b proteins. Moreover, we have shown by alanine-stretch-scanning mutagenesis that (i) residues R(11) to G(13) are major determinants for correct translocation and folding of PBP1b and that (ii) the specific interactions involving the full-length PBP1b can be ascribed to the first six residues at the N-terminal end of the cytoplasmic domain. These results are discussed in terms of the interactions with other components of the murein-synthesizing complex.  (+info)

Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study. (7/239)

Linezolid, the first oxazolidinone, is active against gram-positive bacteria, including multidrug-resistant strains. This multinational, randomized, double-blind, controlled trial compared the efficacy, safety, and tolerability of linezolid with vancomycin in the treatment of nosocomial pneumonia. A total of 203 patients received intravenous linezolid, 600 mg twice daily, plus aztreonam, and 193 patients received vancomycin, 1 g intravenously twice daily, plus aztreonam for 7-21 days. Clinical and microbiological outcomes were evaluated at test of cure 12-28 days after treatment. Clinical cure rates (71 [66.4%] of 107 for linezolid vs. 62 [68.1%] of 91 for vancomycin) and microbiological success rates (36 [67.9%] of 53 vs. 28 [71.8%] of 39, respectively) for evaluable patients were equivalent between treatment groups. Eradication rates of methicillin-resistant Staphylococcus aureus and safety evaluations were similar between treatment groups. Resistance to either treatment was not detected. Linezolid is a well-tolerated, effective treatment for adults with gram-positive nosocomial pneumonia.  (+info)

SHV-27, a novel cefotaxime-hydrolysing beta-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital. (8/239)

From a collection of cefotaxime-resistant Klebsiella pneumoniae isolated from neonatal blood culture specimens in a maternity hospital in Aracaju, Brazil, two isolates (strains KPBRZ-842 and -843, indistinguishable by pulsed-field gel electrophoresis) were found to produce beta-lactamases with isoelectric points (pI) of 5.4 and 8.2, respectively. Using a gel overlay method, cefotaxime hydrolysis was shown to be associated with the pI 8.2 protein. Nucleotide sequencing of the gene encoding the pI 8.2 beta-lactamase revealed a bla(SHV-ESBL)-type gene differing from the gene encoding SHV-1 by three silent point mutations, and a fourth that resulted in an amino acid substitution, aspartate for glycine, at position 156. This novel SHV-type extended-spectrum beta-lactamase is designated SHV-27.  (+info)

TY - JOUR. T1 - Inhaled aztreonam lysine for chronic airway Pseudomonas aeruginosa in cystic fibrosis. AU - McCoy, Karen S.. AU - Quittner, Alexandra L.. AU - Oermann, Christopher M.. AU - Gibson, Ronald L.. AU - Retsch-Bogart, George Z.. AU - Montgomery, A. Bruce. PY - 2008/11/1. Y1 - 2008/11/1. N2 - Rationale: The effectiveness and safety of aztreonam lysine for inhalation (AZLI) in patients with cystic fibrosis (CF) on maintenance treatment for Pseudomonas aeruginosa (PA) airway infection was evaluated in this randomized, double-blind, placebo-controlled study. Objectives: To evaluate the safety and efficacy of inhaled aztreonam lysine in controlling PA infection in patients with CF. Methods: After randomization and a 28-day course of tobramycin inhalation solution (TIS), patients (n = 211; ≥6yr; ≥3 TIS courses within previous year; FEV1 ≥25% and ≤75% predicted values) were treated with 75 mg AZLI or placebo, twice or three times daily for 28 days, then monitored for 56 days. The ...
This program is to provide expanded access to aztreonam lysine for inhalation (AZLI) prior to its commercial availability to patients with cystic fibrosis (CF)
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10 1/2 x 16 paper print by artist John Frederick Herring Other choices available: 14 3/8 x 22 paper print shipped free for $54.95 19 5/8 x 30 paper print shipped free for $74.95 23 5/8 x 36 paper print shipped free for $89.95 10 1/2 x 16 unstretched canvas giclee shipped free for $109.95 14 3/8 x 22 unstretched canvas giclee shipped free for $159.95 19 5/8 x 30 unstretched canvas giclee shipped free for $189.95 23 5/8 x 36 unstretched canvas giclee shipped free for $209.95 10 1/2 x 16 stretched canvas giclee shipped free for $139.95 14 3/8 x 22 stretched canvas giclee shipped free for $194.95 19 5/8 x 30 stretched canvas giclee shipped free for $249.95 23 5/8 x 36 stretched canvas giclee shipped free for $279.95 Choose from drop down menu above Unstretched canvases are shipped rolled in a tube and will require a frame. Stretched canvases are mounted and ready to hang but they are not framed.
commit 9c3d34ca4db43e65b51407450b01d934df0821c2 Author: Stefan Schmidt ,[email protected], Date: Tue Apr 26 10:30:50 2016 +0200 docs: evas: description for various surface classes Describing surfaces classes for Wayland, TBM and X11. --- src/lib/evas/canvas/efl_canvas_surface_tbm.eo , 2 ++ src/lib/evas/canvas/efl_canvas_surface_wayland.eo , 2 ++ src/lib/evas/canvas/efl_canvas_surface_x11.eo , 2 ++ 3 files changed, 6 insertions(+) diff --git a/src/lib/evas/canvas/efl_canvas_surface_tbm.eo b/src/lib/evas/canvas/efl_canvas_surface_tbm.eo index 9d16dc8..546cb21 100644 --- a/src/lib/evas/canvas/efl_canvas_surface_tbm.eo +++ b/src/lib/evas/canvas/efl_canvas_surface_tbm.eo @@ -1,5 +1,7 @@ class Efl.Canvas.Surface_Tbm (Efl.Canvas.Surface) { + [[Native Tizen Buffer Manager surface for Efl canvas]] + legacy_prefix: null; implements { Eo.Base.constructor; diff --git a/src/lib/evas/canvas/efl_canvas_surface_wayland.eo b/src/lib/evas/canvas/efl_canvas_surface_wayland.eo index 9cf9114..4734ef0 100644 --- ...
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A Canvas sandbox is a course without student enrollments where instructors can create, modify, and preview course content and structure without student interference. They can then share or import sandbox content into live courses. Instructors may be able to start a new course as a sandbox course from their Canvas dashboard. A Canvas sandbox may also refer to an institutions beta environment where admins and instructors can enable and use upcoming Canvas features. Admins may use the Canvas beta environment to review how feature options impact users and courses in their account. Instructors may use the Canvas beta environment to test features and build course content.. ...
canvas is a reference to a ,canvas, element var context = canvas.getContext(2d); context.fillRect(0,0,50,50); canvas.setAttribute(width, 300); // clears the canvas context.fillRect(0,100,50,50); canvas.width = canvas.width; // clears the canvas context.fillRect(100,0,50,50); // only this square ...
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On 2/3/10 1:01 PM, Tim Hutt wrote: , Good point, it would be better to call it onresize for consistency. , So my revised suggestion is: , , 1. Support more length specifiers for the width and height of a , canvas(%, em, etc.). , 2. Add an onresize event to the canvas tag. When the canvas is resized , it is reset and this event is fired. , 3. CSS size specifiers resize rather than scale the canvas. I.e. it , should always be that 1 unit = 1 pixel initially. #3 would break existing canvas content. #2 would work if all elements supported onresize (as has been proposed), right? Given that, a resize handler could simply reset the canvas width/height attrs if desired (thereby achieving #1 and the clearing aspect of #2), no? Hence my question: what use cases here would not be covered simply by having a general resize event on all elements? -Boris ...
PS - Ingenieros. Programación y realización del Taller de Canvas Entrega de Canvas de los colaboradores Programar junta con jefe directo a cada uno de los puestos para presentar y discutir su Canvas Programar segunda cita con proveedores y clientes internos de cada puesto para presentar su Canvas D.O. recolecta todos los Canvas y los integra a los perfiles de puesto de cada empresa ETAPA 1 ETAPA 3 ETAPA 2 2002 March Colaboradores generan Canvas de su puesto Presentar qué es y cómo hacer un ...
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In reply to comment #6) , (From update of attachment 43541 [details]) , I leave the final review to Ollie, but here is my take: , , , Index: WebCore/WebCore.gypi , , =================================================================== , , --- WebCore/WebCore.gypi (revision 51226) , , +++ WebCore/WebCore.gypi (working copy) , , @@ -1271,6 +1271,20 @@ , , history/HistoryItem.h, , , history/PageCache.cpp, , , history/PageCache.h, , , + html/canvas/CanvasGradient.cpp, , , + html/canvas/CanvasGradient.h, , , + html/canvas/CanvasObject.cpp, , , + html/canvas/CanvasObject.h, , , + html/canvas/CanvasPattern.cpp, , , + html/canvas/CanvasPattern.h, , , + html/canvas/CanvasPixelArray.cpp, , , + html/canvas/CanvasPixelArray.h, , , + html/canvas/CanvasRenderingContext.cpp, , , + html/canvas/CanvasRenderingContext.h, , , + html/canvas/CanvasRenderingContext2D.cpp, , , + html/canvas/CanvasRenderingContext2D.h, , , + html/canvas/CanvasStyle.cpp, , , + html/canvas/CanvasStyle.h, ...
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It was a remarkable day yesterday. In spite of new guidance (still flawed in my view) on clinical trial design in pneumonia and in skin infections, the FDA review of the data developed under the old guidelines by Cerexa/Forest for ceftaroline was balanced and informative. The incredibly tight data and very well designed studies saved the day. Not only did the ceftaroline data, with studies powered for a 10% NI margin, come in at 4 or 5% overall, but almost all of the subgroup analyses carried out by both the sponsor and the FDA (and some of these subgroups were small!!) came in with NI margins under 10% compared to either ceftriaxone in the pneumonia studies or vancomycin plus aztreonam in the skin infection studies. But in addition, the spectacular data allowed the FDA to accept studies carried out under an old paradigm and to use a post-hoc approach to examine putative new endpoints in an exploratory way. I discussed the idea to use this approach with the FDA back in April. ...
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My mother did a crayon painting on canvas (24 X 36)years ago. She just moved to a smaller place and gave it to a friend. She used shaved crayons, covered the areas of the canvas with wax paper and used a warm iron. I wish I had a picture to show you; it looked like a crystal cave, full of beautiful colored patterns. I was in the process of shaving some crayons when I decided to look up this form of art on the web. Im glad to see it is still done. Nice work Jenna and Matthew!I really like the fact that you left some of the white canvas show. I bet a black gessoed canvas would not look too bad either. I am going to Walmart today and Im going to buy a wand type mini iron; the head is triangular so it might work well on a smaller canvas. I will let you know the results. The skys the limit! Diane from Kamloops, BC Canada. ReplyDelete ...
My mother did a crayon painting on canvas (24 X 36)years ago. She just moved to a smaller place and gave it to a friend. She used shaved crayons, covered the areas of the canvas with wax paper and used a warm iron. I wish I had a picture to show you; it looked like a crystal cave, full of beautiful colored patterns. I was in the process of shaving some crayons when I decided to look up this form of art on the web. Im glad to see it is still done. Nice work Jenna and Matthew!I really like the fact that you left some of the white canvas show. I bet a black gessoed canvas would not look too bad either. I am going to Walmart today and Im going to buy a wand type mini iron; the head is triangular so it might work well on a smaller canvas. I will let you know the results. The skys the limit! Diane from Kamloops, BC Canada. ReplyDelete ...
DOCTYPE html, ,html, ,head, ,title,Experimenting Canvas,/title, ,script src=https://cdn.rawgit.com/moczka/One-Ball-Physics/master/modernizr.js,,/script, ,script, //adds the event listeners to be triggered when everything has loaded window.addEventListener(load, onWindowLoad, false); function onWindowLoad(){ //calls the main function after the window event has triggerd canvasApp(); } //function part of the modernizr to check if canvas is supported. function canvasSupport () { return Modernizr.canvas; } function canvasApp(){ //if the opposite of canvas support is true, means there is no support and exits the program. if(!canvasSupport()){ return; } //creates the canvas objet and gets its context. var theCanvas = document.getElementById(theCanvas); var context = theCanvas.getContext(2d); //Creates our ball object. var ball = {radius:20, x:theCanvas.width/2, y:theCanvas.height/2, color:#00FF00, angle:0, speed:10, velX:0, velY:0, elasticity:0.80}; ball.angle = -45; //converts our starting ...
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Add the festive spirit to your walls this Christmas with our Christmas scene canvas prints... To see the rest of the Christmas range click here All of our canvas prints are hand stretched and ready to hang with wall brackets included. Material: Canvas is printed onto high quality 330gsm canvas material with a matte fin
Arid Earth is a Mixed Media artwork featuring a landscape of contrast and texture. Upon the canvas, there are black, branching gemstones of Tourmaline, set amongst a crackled earth and dusky-pink sky. This piece evokes the rich themes of sunset, breath, desert, summer, expanse, and flora, that are found in many Australian landscapes. Arid Earth sits in a deep frame, allowing it to be hung on the wall or placed standing on its own. Details: Canvas Size - 8 x 10 inches (20 cm x 25 cm) Canvas Depth - 2 inches (6 cm) Framed - Yes Varnished - Yes Colours - Gold, bronze-brown, gemstone black, and dusky pink Materials - Tourmaline, acrylic paint, crackle *Please Note: Keep out of reach of children. Each artwork has been varnished to secure the materials to the canvas, however it is not made to be overly-handled or touched. Arid Earth is an original, framed, mixed media artwork by Mandy Barnard, owner of ForeverForagingArt. Handmade in Australia. Follow me and my work process on
All students taking Hybrid and Online classes are required to complete a Canvas Orientation. To register for the orientation go to http://jwebtasks.jsums.edu/studenttraining2/Schedule.aspx. All users must have a Network Identifier (NetID) to log into Canvas. The NetID is used to access Canvas, the Xerox Copiers, online Library Resources, and Computer Labs. To obtain a NetID, log into JSU PAWS and select Activate NetID, Change NetID Password (twice). Your password must follow one of the criteria listed on the screen. Once successfully created your username is your JNumber and your password will be the password you created. To log into Canvas click here. ...
REDRIX RED LABEL Canvas features superior quality, medium texture, 100% Cotton duck canvas. Red Label uses our canvas #569 which is a 12 oz primed / 7 oz raw 100% Cotton duck canvas. We have double-primed Red Label just north of Atlanta, Georgia, with an acid-free acrylic titanium gesso for professional results. Our 15
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Alibaba.com offers 334 new york canvas arts products. About 86% of these are painting & calligraphy, 1% are painting canvas. A wide variety of new york canvas arts options are available to you, such as printed, handpainted.
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Plastic canvas cords or PVC metallic cord is a must have for plastic canvas crafters This PVC Metallic Cord is a shiny two-toned metallic that is used for needlecrafts using plastic canvas
Choose from our wide range of Nature Art canvas prints and canvas wall art. Printed on high quality canvas, stretched and ready to hang.
Choose from our wide range of Nature Art canvas prints and canvas wall art. Printed on high quality canvas, stretched and ready to hang.
Choose from our wide range of Nature Art canvas prints and canvas wall art. Printed on high quality canvas, stretched and ready to hang.
Canvas is UWMs campus-supported digital learning environment. Your instructors may use Canvas to have you access readings, watch videos, take quizzes, submit assignments, and participate in online discussions. You can access Canvas on your computer using a browser and on your mobile device by downloading the Canvas Student app.. ...
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Every idea for a new organization or program is based on initial assumptions. A canvas articulates these assumptions quickly and clearly so that you can easily compare organizational or program models by creating multiple canvases.. You can then use these canvases as a starting point to validate assumptions about both your beneficiaries and donors by soliciting feedback from stakeholders. This results in both more effective programs and fundraising campaigns.. When applying for funding from foundations or government, you may have to go through an onerous proposal writing process that carries no guarantees for funding. The more you can demonstrate results from your programs by running small tests on the critical assumptions in your proposal, the more likely you will be to secure funding. I recommend using the lean canvas to outline and test the assumptions in your program or organization before you begin to write funding proposals.. ...
html, ,head, ,script, // A canvas demo by Kas Thomas. // http://asserttrue.blogspot.com // Use as you will, at your own risk. context = null; canvas = null; window.onload = function(){ canvas = document.getElementById(myCanvas); canvas.addEventListener(mousemove, handleMousemove, false); context = canvas.getContext(2d); loadHiddenText(); } function loadHiddenText( ) { var options = document.getElementsByTagName( option ); var spans = document.getElementsByTagName( span ); for (var i = 0; i , options.length; i++) options[i].value = spans[i].innerHTML; } // should probably be called resetCanvas() function clearImage( ) { canvas.width = canvas.width; } function drawViaCallback( ) { var w = canvas.width; var h = canvas.height; var canvasData = context.getImageData(0,0,w,h); for (var idx, x = 0; x , w; x++) { for (var y = 0; y , h; y++) { // Index of the pixel in the array idx = (x + y * w) * 4; // The RGB values var r = canvasData.data[idx + 0]; var g = canvasData.data[idx + 1]; var b = ...
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add a method to 2D that adds a region to the canvas: addHitRegion({ path: path, // Path to use as region description, defaults to the contexts default path element: element, // Element to send events to; limited at hit-test time to specific interactive elements id: id, // DOMString to use as the ID in events fired on the canvas for this region (MouseEvent gets new attribute for this purpose); also used for parentID references // if element is present, label, ariaRole, and parentID must not be: label: label, // DOMString to use as a label when the user strokes a touch display or focuses the hit region with an AT ariaRole: ariaRole, // DOMString limited to specific roles, AT uses this to decide how to expose the region parentID: parentID, // DOMString, AT uses this to decide which region to use as this regions parent (defaults to canvas as parent) // one of element, label, id, or ariaRole must be present; exception otherwise? no-op? // ariaRole must be present if parentID is present; exception ...
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Cure: Total resolution of all signs and symptoms of the baseline infection, or improvement of the infection such that no further antimicrobial therapy was necessary.. Failure: Requirement of alternative antimicrobial therapy for primary infection of complicated skin and skin structure infection (cSSSI) due to inadequate response, recurrence, new infection at the same site; treatment-limiting adverse event (AE); requirement for surgery due to failure of study drug; diagnosis of osteomyelitis after Study Day 8; or death caused by cSSSI.. Indeterminate: Inability to determine an outcome ...
Ceftaroline fosamil is a new drug in development for the treatment of community acquired bacterial pneumonia and complicated skin and skin structure infections. Ceftaroline fosamil information includes news, clinical trial results and side effects.
FOSTER CITY, Calif. & SEATTLE, Apr 12, 2006 (BUSINESS WIRE) -- Gilead Sciences, Inc. (Nasdaq:GILD) and Corus Pharma, Inc. today announced that Gilead has invested $25 million in Corus, a privately-held Seattle-based company focused on the development of novel drugs for respiratory diseases. In return for the investment, Gilead will receive preferred shares in Corus and will become the second largest shareholder in the company. Gilead will also have an exclusive option to purchase the remaining shares of Corus at a pre-specified price. Corus lead product candidate, Cayston(TM) (aztreonam lysine for inhalation), is an inhaled antibiotic with activity against gram-negative bacteria including Pseudomonas aeruginosa, which can cause lung infections in patients with cystic fibrosis (CF). Corus is currently enrolling Phase III studies to evaluate the product as a potential treatment for CF-related pulmonary infections. Aztreonam lysine for inhalation was granted orphan drug status by the U.S. Food & ...
Reproductions of original artwork have been printed on canvas for many decades using offset printing. Since the 1990s, canvas print has been also been associated with either dye sublimation or inkjet print processes (often referred to as repligraph or giclée[1] respectively). The canvas print material is generally cotton or plastic based poly canvas, often used for the reproduction of photographic images. Digital printers capable of producing canvas prints range from small consumer printers owned by the artist or photographer themselves up to large format printing service printers capable of printing onto canvas rolls measuring 1.5 metres (59 in) or more. Digital files of artwork, paintings, photograph, or drawings may be sent directly to printing companies or Internet based printing services. ...
03.25.2015. Epson America today expanded its portfolio of solvent media with the new Epson GS Canvas Production Satin. Designed to meet the needs of high volume production applications achieved with Epson SureColor® S-Series solvent printers, GS Canvas Production Satin provides art reproduction houses unmatched image quality at production speeds, while delivering superior resolution and saturation with the traditional look and feel of artist canvas. With an expanded gamut for exceptional colors and industry-leading Dmax for deep, dark blacks, Epson GS Canvas Production Satin is an acid free, lignin free heavyweight cotton-polyester blend ideal for a range of photographic and fine art reproductions. We listened to our customers and industry experts - fine artists, professional photographers, museums, gallery owners, and fine art reproduction shops - to develop a high quality canvas available at production pricing that meets even the most demanding requirements, said Jeff Smith, product ...
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waxed canvas tote, large canvas tote, crossbody waxed canvas tote, tote bag, large tote, waxed canvas bag, waxed canvas crossbody bag ****As of March 19th, 2020, each bag purchase from In Blue Handmade gives 50 meals to a network of 60,000 food banks nationwide during this unprecedented world crisis. See listing pictur
this listing is for a zipper tote bag made from waxed canvas top portion made from charcoal waxed canvas that has blue undertones and the bottom portion with dark oak coloured waxed canvas, with handles made from leather in a beautiful dark brown colour FABRIC INFO: this waxed canvas is weather resistant and has a nice
Our museum grade framed canvas combined with state of the art printing technology results in sharp photographic reproduction and color. fidelity using archival inks. Our premium poly-cotton blend canvas is then stretched on a high grade 1.25 inch thick wooden stretched bar, made of 100% renewable, film dried, knot free, finger jointed wood. This means that our canvas digital prints will last a lifetime and maintain the vibrancy of a freshly printed piece much longer than the paper alternative. Some traditional canvas manufacturers may use varnish as a coating, but we are able to bypass that process due to our unique print technology and inks. Our factory is the top notch factory in the USA known for its environmentally friendly and sustainable process. Our eco-ink makes it safe for kids and pets.. Features:. ...
Our museum grade framed canvas combined with state of the art printing technology results in sharp photographic reproduction and color. fidelity using archival inks. Our premium poly-cotton blend canvas is then stretched on a high grade 1.25 inch thick wooden stretched bar, made of 100% renewable, film dried, knot free, finger jointed wood. This means that our canvas digital prints will last a lifetime and maintain the vibrancy of a freshly printed piece much longer than the paper alternative. Some traditional canvas manufacturers may use varnish as a coating, but we are able to bypass that process due to our unique print technology and inks. Our factory is the top notch factory in the USA known for its environmentally friendly and sustainable process. Our eco-ink makes it safe for kids and pets.. Features:. ...
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Canvas Tapestry are the perfect pieces to quickly hang or rearrange your favorite art with each new season. Magnetic wooden rails are included with each Canvas Tapestry, so swapping out art is a snap. Canvas corners are secured tightly and are weighted to prevent any wrinkles or ripples. Pricing shown here is final; no additional coupons, vouchers, or discounts may be applied.. ...
Soul of Sound by Ashvin Harrison is produced with printing that covers the entirety of the canvas for a sleek and stylish museum-quality look. Our framed prints are made by expert craftsmen who strive to make each canvas the masterpiece that your home deserves. Each of our framed canvas art prints is hand-crafted and m
This Sigman 8 x 50 Polyester Canvas Tarp is designed for superior all-purpose outdoor tarp cover performance and Made in USA. Highly UV resistant and tear resistant. Made from durable silicone treated polyester canvas fabric. Fabric Weight: 14.5 oz / sq. yard. Silicone treated polyester canvas tarp is water resistant
This Sigman 6 x 8 Polyester Canvas Tarp is designed for superior all-purpose outdoor tarp cover performance and Made in USA. Highly UV resistant and tear resistant. Made from durable silicone treated polyester canvas fabric. Fabric Weight: 14.5 oz / sq. yard. Silicone treated polyester canvas tarp is water resistant,
New York Hat Company Six Panel Canvas Skull Cap Beanie Hat Beanies   Made in the USA   Made of durable cotton canvas, the Six Panel Canvas Skull Cap Beanie Hat has the classic dome-hugging skull cap look and feel in a hard-wearing and natural material. Featuring their classic six-panel ...
Reiver Media Canvas varnish, known as giclee varnish or laminate, is used to protect canvas prints from sunlight damage, keeps your canvas colours bright.
An all-purpose canvas, Classic Cotton Stretched Canvas is great for traditional painting techniques as well as mixed media, aerosol art, home decor and craft pr
Forgot Password? Enter your Username: (example: 24[email protected]⠢⠢⠢⠢⠢⠢⠢.org) and well send you a link to change your password. Ask A Librarian. Homepage; News & Events; Contact Us; BC High Spirit Wear; Summer Programs; Mission The agora.bc.edu server is no longer in service. With Canvas, university community members will enjoy an LMS that is mobile-first, reliable, accessible, and can deliver highly customizable and experiential teaching and learning. Browse courses Log In Email. DTLA edges closer to completion. Beacon Collegeâ where lifeâ s adventure truly begins. â Syllabus Searchâ is a Canvas tool that provides instructors the opportunity to share course syllabi with students in the BC Canvas community. Boston College High School is a private, college preparatory day school for Boys in Boston, serving grades 7 through 12. Address: Level 3/302 Elizabeth street, Surry Hills, NSW 2010 Email: [email protected] Phone: +61 2 8252 9999 Donate Online Now Love you all :) Read ...
define __SP_CANVAS_ACETATE_C__ /* * Infinite invisible canvas item * * Author: * Federico Mena ,[email protected], * Raph Levien ,[email protected], * Lauris Kaplinski ,[email protected], * * Copyright (C) 1998-1999 The Free Software Foundation * Copyright (C) 2002 Lauris Kaplinski * * Released under GNU GPL, read the file COPYING for more information */ #include display-forward.h #include gnome-canvas-acetate.h static void sp_canvas_acetate_class_init (SPCanvasAcetateClass *klass); static void sp_canvas_acetate_init (SPCanvasAcetate *acetate); static void sp_canvas_acetate_destroy (GtkObject *object); static void sp_canvas_acetate_update (SPCanvasItem *item, NR::Matrix const &affine, unsigned int flags); static double sp_canvas_acetate_point (SPCanvasItem *item, NR::Point p, SPCanvasItem **actual_item); static SPCanvasItemClass *parent_class; GtkType sp_canvas_acetate_get_type (void) { static GtkType acetate_type = 0; if (!acetate_type) { GtkTypeInfo acetate_info = { ...
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Aztreonam is a commercially available monobactam antibiotic. Other examples of monobactams are tigemonam, nocardicin A, and ... which contains an identical side chain as aztreonam. Monobactams can trigger seizures in patients with history of seizures, ...
Inhaled therapy with antibiotics such as tobramycin, colistin, and aztreonam is often given for months at a time to improve ... McCoy KS, Quittner AL, Oermann CM, Gibson RL, Retsch-Bogart GZ, Montgomery AB (November 2008). "Inhaled aztreonam lysine for ...
antipseudomonal penicillins, aminoglycosides, fluoroquinolones, third generation cephalosporins or ceftriaxone aztreonam can be ...
For penicillin allergic people, aztreonam or a quinolone with metronidazole may be used.[citation needed] In cases of severe ...
The drugs that specifically target gram-negative organisms include aminoglycosides, monobactams (aztreonam) and ciprofloxacin. ... Other classes of drugs that have gram negative spectrum include cephalosporins, monobactams (aztreonam), aminoglycosides, ...
They are: cephalosporins, carbapenems, aztreonam, clindamycin, erythromycin, nitrofurantoin, bacitracin, doxycycline, ...
Options for inhaled antibiotics include aerosolized tobramycin, inhaled ciprofloxacin, aerosolized aztreonam, and aerosolized ...
... and aztreonam. Current clinical guidelines recommend that C.valvarum infection be treated with a 4-week course of ceftriaxone ...
Aztreonam is stable to the metallo-β-lactamases, but many IMP and VIM producers are resistant, owing to other mechanisms. ... These cephalosporins include cefotaxime, ceftriaxone, and ceftazidime, as well as the oxyimino-monobactam aztreonam. Thus ESBLs ... and aztreonam, even if it is tested (in vitro) as susceptible.[citation needed] Associated resistance to aminoglycosides and ... as well as the oxyimino-monobactam aztreonam), but not 7-alpha-methoxy-cephalosporins (cephamycins; in other words, cefoxitin ...
... shares the same variable R-group side chain with aztreonam, a monobactam antibiotic; the two drugs share a similar ...
Meropenem and aztreonam are additional antibiotic options that are effective against gram-negative bacterial infections. To ...
E. faecalis is usually resistant to many commonly used antimicrobial agents (aminoglycosides, aztreonam and quinolones. The ...
Wainwright CE, Quittner AL, Geller DE, Nakamura C, Wooldridge JL, Gibson RL, Lewis S, Montgomery AB (July 2011). "Aztreonam for ...
... and aztreonam. C. hominis is often resistant to erythromycin. Since cefotaxime use may be not appropriate for C. hominis ...
Corus was developing aztreonam lysine for the treatment of patients with cystic fibrosis who are infected with Pseudomonas ...
By modifying the amide side chain and including a ceftazidime side chain, he produced aztreonam, the first monocyclic β-lactam ... Subsequently, he was recruited by the Squibb Institute, in the United States, where he then developed aztreonam, the first ...
For example, the drug Cayston (aztreonam), marketed by Gilead Sciences for cystic fibrosis, can be identified and characterized ...
Resistance has been elucidated to aztreonam, ampicillin, tetracycline, cephalosporins, penicillins, sulbactams, sulfonamides, ...
C. violaceum produces a number of natural antibiotics: Aztreonam is a monobactam antibiotic that is active against gram- ... For theoretical reasons, infection would not be expected to respond to penicillins, cephalosporins, or aztreonam, although ...
While at The Squibb Institute, Bush was part of the team that discovered Aztreonam and rose from a Research Investigator ... or aztreonam-avibactam combinations. Antimicrob Agents Chemother, August 2017 61:e00389-17. Bush, K., P. Courvalin, G. Dantas, ... or Aztreonam-Avibactam". Antimicrobial Agents and Chemotherapy. 61 (8): e00389-17, e00389-17. doi:10.1128/AAC.00389-17. ISSN ... aztreonam, piperacillin-tazobactam, levofloxacin, doripenem and ceftobiprole). As a Professor, Bush has continued to lead ...
Vancomycin plus Aztreonam in Complicated Skin and Skin Structure Infections (cSSSI). 2008 Interscience Conference on ... The CANVAS I and CANVAS II trials evaluated ceftaroline monotherapy versus vancomycin plus aztreonam in adult subjects with ... skin and skin structure infections with reported non-inferior efficacy against MRSA compared to vancomycin and aztreonam. In ...
... aztreonam, trimethoprim-sulfamethoxazole, ciprofloxacin, nitrofurantoin and the aminoglycosides. Antibiotic resistance is a ...
... as Feltner's AIDS had been getting progressively worse despite treatment with Aztreonam. As a result of this, he died on March ...
... evidence is insufficient about the effectiveness of long-term antibiotic treatment with continuous inhaled aztreonam lysine ( ...
Polymyxin B Aztreonam (monobactam) Aminoglycosides Antibiotics that cover vancomycin-resistant Enterococcus (VRE): Linezolid ...
... aztreonam MeSH D03.383.411.500 - moxalactam MeSH D03.383.517.200 - carboxin MeSH D03.383.533.249 - benzoxazines MeSH D03.383. ...
carbapenems (meropenem, imipenem, doripenem, but not ertapenem) polymyxins (polymyxin B and colistin) monobactams (aztreonam) ...
... successfully completed phase III trials in which it was at least equal to intravenous vancomycin and aztreonam to ...
... was approved by the FDA in June 2017, after it was noninferior to vancomycin plus aztreonam in two trials on 1042 ...
... among Escherichia coli and Klebsiella isolates with hidden resistance to expanded-spectrum cephalosporins and aztreonam? ...
How does inhaled aztreonam compare with IV aztreonam? ... Aztreonam Lysine for Inhalation. New Formulation of an Old ... In a Phase I trial, inhaled aztreonam was shown to be noninferior to the original i.v. formulation, aztreonam arginine, with ... Interestingly, i.v. aztreonam exhibits little to no "inoculum effect" in P. aeruginosa infections.[17,22,24] Negligible gram- ... Synergy has been observed when aztreonam is coadministered with an aminoglycoside in P. aeruginosa infections, likely due to ...
Aztreonam Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... You may receive aztreonam injection in a hospital, or you may use the medication at home. If you will be using aztreonam ... Use aztreonam injection until you finish the prescription, even if you feel better. If you stop using aztreonam injection too ... Before using aztreonam injection,. *tell your doctor and pharmacist if you are allergic to aztreonam, cephalosporins such as ...
As of the 1st Quarter of 2019, the use of aztreonam at the facility has decreased to approximately 10 antimicrobial days per ... A Veterans Affairs (VA) hospital evaluated use of aztreonam by analyzing NHSN Antimicrobial Use (AU) Option data pulled monthly ... Decreasing Aztreonam Use in a Veterans Affairs Hospital. ... the P&T Antimicrobial Subcommittee identified aztreonam as an ... The educational tool also provided guidance for recommending alternatives to aztreonam based on this risk. The facility decided ...
Aztreonam exhibits cross-sensitivity with ceftazidime due to a similar side chain. Aztreonam is similar in action to penicillin ... Aztreonam is bactericidal, but less so than some of the cephalosporins.[medical citation needed] "Aztreonam". The American ... Aztreonam inhibits cell wall synthesis by blocking peptidoglycan crosslinking to cause bacterial death. Aztreonam was approved ... In these circumstances aztreonam is combined with avibactam (ceftazidime/avibactam). The combination of aztreonam and avibactam ...
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
Aztreonam is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Aztreonam has activity in the ... All of the above doses of aztreonam for injection result in average urine levels of aztreonam that exceed the MIC90 for the ... Unchanged aztreonam and the inactive beta-lactam ring hydrolysis product of aztreonam were present in feces and urine. ... Aztreonam for Injection, USP contains the active ingredient aztreonam, a monobactam. It was originally isolated from ...
... aztreonam), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, ... encoded search term (aztreonam (Azactam)) and aztreonam (Azactam) What to Read Next on Medscape ...
... use of Respiratory Domain of the Quality of Life Questionnaire-Bronchiectasis in evaluating patients taking inhaled aztreonam. ... Quality of Life Questionnaire for Bronchiectasis Tested Alongside Aztreonam. Jan 15, 2015 , Cystic fibrosis, Testing , ... in evaluating patients taking inhaled aztreonam, a drug used to treat cystic fibrosis lung infections. ...
Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from Chromobacterium violaceum. Aztreonam ... Aztreonam maintains its antimicrobial activity over a pH range of 6 to 8 in vitro, as well as in the presence of human serum ... In healthy subjects, aztreonam is excreted in the urine about equally by active tubular secretion and glomerular filtration. ... The serum half-life of aztreonam averaged 1.7 hours (1.5 to 2.0) in subjects with normal renal function, independent of the ...
AZTREONAM INN patents, expiration and generic drug launch ... Aztreonam - Generic Drug Details. ⮩ Send this page by email. ✉ ... AZTREONAM. aztreonam. INJECTABLE;INJECTION. 206517-001. Nov 8, 2021. AP. RX. No. No. See Plans and Pricing. See Plans and ... AZTREONAM. aztreonam. INJECTABLE;INJECTION. 065439-002. Jun 18, 2010. AP. RX. No. No. See Plans and Pricing. See Plans and ... AZTREONAM. aztreonam. INJECTABLE;INJECTION. 065286-001. Mar 23, 2011. DISCN. No. No. See Plans and Pricing. See Plans and ...
Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. ... Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. ... Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. ... Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. ...
Unlike the penicillins and cephalosporins, aztreonam is a monobactam. Monobactams such as aztreonam are bactericidal; however, ... Aztreonam is approved for the treatment of complicated and uncomplicated cystitis. It is approved for the treatment of ... Aztreonam lacks cross-sensitivity with beta-lactam antibiotics and may be used in patients allergic to penicillins or ...
Aztreonam Chemical_Formula C13H17N5O8S2 ... Aztreonam LogP No information avaliable Aztreonam Dosage Forms ...
Aztreonam (Azactam). *View full drug information. Usually synergistic with amikacin. Use both in combination, pending results ...
Aztreonam. ,64. Nonsusceptible. Gentamicin. 16. Nonsusceptible. Tobramycin. ,32. Nonsusceptible. Amikacin. 32. Nonsusceptible. ...
Learn about aztreonam: What is it used for, what you need to know before taking, important warnings and safety info, how to ... Before taking aztreonam, tell your doctor:. *If you are allergic to aztreonam; any part of this medicine; or any other drugs, ... How is aztreonam best taken?. Use aztreonam as ordered by your doctor. Read all information given to you. Follow all ... What is aztreonam used for?. *Aztreonam is used in some people with cystic fibrosis to make breathing better. ...
AZACTAM® (aztreonam for injection, USP) is contraindicated in patients with known hypersensitivity to aztreonam or any other ... AZACTAM® (aztreonam for injection, USP) is contraindicated in patients with known hypersensitivity to aztreonam or any other ... Aztreonam crosses the placenta and enters the fetal circulation. Aztreonam is excreted in human milk so consideration should be ... AZACTAM® (aztreonam for injection, USP) should be used only to treat or prevent infections that are proven or strongly ...
CAYSTON is a specialty drug on the Reformulary and can be used to treat Cystic Fibrosis. Check with your doctor if there are other medications you can take before taking this drug.
"Δισκοι ευαισθησίας αντιβιωτικών Aztreonam ATM 30 µg της LIOFILCHEM Ιταλίας Συσκευασία 50 δίσκων ... Δίσκοι Αντιβιοτικών Aztreonam ATM 30µg. 2,90€. EXW. Δισκοι ευαισθησίας αντιβιωτικών Aztreonam ATM 30 µg της LIOFILCHEM Ιταλίας ... HomeConsumablesΔΙΣΚΟΙ ΑΝΤΙΒΙΩΤΙΚΩΝ Δίσκοι Αντιβιοτικών Aztreonam ATM 30µg. Previous product Δίσκοι Αντιβιοτικών Azithromycin ... Δίσκοι αντιβιωτικών κατάλληλοι για την ανίχνευση ευαισθησίας (αντιβιόγραμμα) στην ουσία Aztreonam ATM. ...
... aztreonam for injection should be used only to treat or prevent infections that are proven or strongly ... Rx only To reduce the development of drug-resistant bacteria and maintain the effectiveness of aztreonam for injection and ... Aztreonam for Injection, USP contains the active ingredient aztreonam, a monobactam. It was originally isolated from ... AZTREONAM Quick Finder *. Pfizer samples (for eligible HCPs) Requests for samples of prescription medications can be made by ...
Find the best AZTREONAM or AZACTAM prices near you now with our cost comparison tool and start saving today. ... How much does AZTREONAM or AZACTAM cost near you? ... aztreonam has been added to your Medicine Chest. View My ... AZTREONAM/Azactam (AZ tree oh nam) is an antibiotic. It treats some infections caused by bacteria. It will not work for colds, ...
Incidence of AEs with delafloxacin was comparable to the combination regimen of vancomycin/aztreonam across 2 phase 3 ... No Difference in Adverse Events Between Delafloxacin or Vancomycin/Aztreonam in ABSSSI. Brandon May ... Overall, gastrointestinal AEs were the most common: 17% in the delafloxacin group vs 13% in the vancomycin/aztreonam group. ... Comparison of safety profile of delafloxacin (DLX) versus vancomycin/aztreonam (VAN/AZ) in thetreatment of patients (pts) with ...
... were treated in an open randomized parallel study with either aztreonam or chloramphenicol. Aztreonam was given intramuscularly ... were treated in an open randomized parallel study with either aztreonam or chloramphenicol. Aztreonam was given intramuscularly ... were treated in an open randomized parallel study with either aztreonam or chloramphenicol. Aztreonam was given intramuscularly ... were treated in an open randomized parallel study with either aztreonam or chloramphenicol. Aztreonam was given intramuscularly ...
aztreonam. Minor (1)aztreonam, paromomycin. Either increases effects of the other by pharmacodynamic synergism. Minor/ ... aztreonam. aztreonam, paromomycin. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance ...
10.1 Aztreonam for Injection Industry Value Chain. 10.2 Aztreonam for Injection Upstream Market. 10.3 Aztreonam for Injection ... 7.12.3 AZACTAM Aztreonam for Injection Major Product Offerings. 7.12.4 AZACTAM Aztreonam for Injection Sales and Revenue in ... 7.13.3 Globalstar Aztreonam for Injection Major Product Offerings. 7.13.4 Globalstar Aztreonam for Injection Sales and Revenue ... 8.2 Aztreonam for Injection Production Capacity of Key Manufacturers in Global Market. 8.3 Global Aztreonam for Injection ...
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AZACTAM (aztreonam) 1g Powder for injection shortage. 11 May 2018. Bristol Myers Squibb Australia advises that due to a ... BMS recommends all health care providers prioritise aztreonam for patients they feel are in the greatest need with no other ... manufacturing issue at the active substance manufacturing plance there is a shortage of AZACTAM (aztreonam) 1g powder for ...
Haloperidol reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).
Burgess, D.S.; Summers, K.K.; Hardin, T.C. Pharmacokinetics and pharmacodynamics of aztreonam administered by continuous ...
  • Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. (wikipedia.org)
  • Aztreonam is poorly absorbed when given orally, so it must be administered as an intravenous or intramuscular injection (trade name Azactam), or inhaled (trade name Cayston) using an ultrasonic nebulizer. (wikipedia.org)
  • AZACTAM ® (aztreonam for injection, USP) delivers proven efficacy in the management of certain Gram-negative infections. (bmscustomerconnect.com)
  • AZACTAM ® (aztreonam for injection, USP) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. (bmscustomerconnect.com)
  • AZTREONAM/Azactam (AZ tree oh nam) is an antibiotic. (wellrx.com)
  • Learn moreFeedbackSee morePeople also askALLEnterocolitis TreatmentMicroscopic colitis TreatmentColic TreatmentDiversion colitis TreatmentWhat is the best medicine for E coli?What is the best medicine for E coli?coli?Antibiotics.Trimethoprim/sulfamethoxazole (Bactrim, Bactrim DS, Septra DS, Sulfatrim)Ciprofloxacin (Cipro)Levofloxacin (Levaquin)Amoxicillin (Moxatag)Aztreonam (Azactam)What is the best treatment of Escherichia coli? (family-medical.net)
  • For patients allergic to penicillin, a respiratory fluoroquinolone plus aztreonam (Azactam) are recommended. (usmlestep3blog.com)
  • Extended incubation of 48 h showed an increase in phenotypic resistance for all antimicrobials, ranging from 6.5% for aztreonam and meropenem to 48% for cefepime. (researchgate.net)
  • Over a 6-month period, a retrospective chart review of meropenem , aztreonam, and linezolid - commonly identified as alternative treatments for individuals with beta-lactam allergy - was conducted at a county medical center. (clinicaladvisor.com)
  • It has a synergistic effect when combined with amikacin, tazobactam, meropenem and aztreonam and has low potential for resistance development and the favorable safety and tolerability profile in clinical trials. (medchrome.com)
  • Because of the unfused beta-lactam ring there is somewhat lower cross-reactivity between aztreonam and many other beta-lactam antibiotics, and it may be safe to administer aztreonam to many patients with hypersensitivity (allergies) to penicillins and nearly all cephalosporins. (wikipedia.org)
  • ESBL is a resistance mechanism in which the beta-lactam ring of antibiotics such as penicillins, cephalosporins, and aztreonam is hydrolyzed, inactivating the antibiotic. (hindawi.com)
  • 65 years, or recent history of UTI) are treated with a 7- to 14-day course of antibiotics (eg, levofloxacin, third-generation cephalosporins, or aztreonam). (medscape.com)
  • Detection of ESBL producers' poses a special challenge for clinical microbiology laboratories, although ESBL producing pathogens are able to hydrolyze extended-spectrum penicillins, cephalosporins, and aztreonam, the minimum inhibitory concentrations (MIC) of some and perhaps even all of these agents may be within the susceptible range. (scirp.org)
  • Hydrolyzes carbapenems, penicillins, cephalosporins and aztreonam with varying efficiency. (genebiosystems.com)
  • KPC-positive strains are typically resistant to the penicillins, extended-spectrum cephalosporins, and aztreonam, but the MICs of these drugs and of the carbapenems are reduced in the presence of clavulanic acid due to enzyme inhibition [ 2 ]. (biomedcentral.com)
  • Aztreonam and amikacin were intravenously administered at doses of 2 g/day and 800 mg/day, respectively. (elsevier.com)
  • In conclusion, the combination therapy between aztreonam and amikacin, or ciprofloxacin may be clinically useful for severe infections of MDRP in compromised hosts. (elsevier.com)
  • Newer nebulized (amikacin, aztreonam, colistin, and fosfomycin with tobramycin) and dry powder (ciprofloxacin, colistin, and tobramycin) forms have been developed that may benefit these patients. (bronchiectasisnewstoday.com)
  • Aztreonam is in a class of medications called monobactam antibiotics. (medlineplus.gov)
  • Antibiotics such as aztreonam injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • If you stop using aztreonam injection too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • There is a much lower risk of cross-sensitivity between aztreonam and other beta-lactam antibiotics than within other beta-lactam antibiotics. (wikipedia.org)
  • Both animal and human data suggest that aztreonam for injection is rarely cross-reactive with other beta-lactam antibiotics and weakly immunogenic. (pfizermedicalinformation.com)
  • In the E. coli host, the plasmid expressed a high level of AmpC-like ß-lactamase designated KU and conferred the E. coli transformants to become resistant to ß-lactam antibiotics, such as aztreonam, cefuroxime, cefotaxime and ceftazidime. (avhandlingar.se)
  • Aztreonam belongs to the class of medications called antibiotics . (rxhealthmed.ca)
  • SAFODEX 50 DRY SYRUP should be avoided if you are allergic to cefpodoxime or to the cephalosporin group of antibiotics (such as cefuroxime, cefixime) or if you had experienced immediate or severe hypersensitivity reaction (anaphylaxis) to penicillin or other beta-lactam antibiotics (such as aztreonam). (netmeds.com)
  • This new generation of antibiotics includes aztreonam (better known as Cayston™), which acts directly against Pseudomonas . (vivreaveclafibrosekystique.com)
  • pelargonii (Xcp) in plant material, two new semi-selective media were developed, the Tween-cellobiose-medium with the antibiotics Cephalexin, 5-Fluorouracil, Tobramycin and Cycloheximid and the MD5A-medium with cellobiose, glutamic acid, methionine and the antibiotics Cephalexin, Bacitracin and Aztreonam, and with bromothymol blue. (uni-goettingen.de)
  • Extended-spectrum beta-lactamases (ESBLs) efficiently hydrolyze extended-spectrum beta-lactams such as cefotaxime, ceftriaxone, ceftazidime, and aztreonam. (elsevier.com)
  • [ 17 , 22 ] I.V. aztreonam maintains stability to hydrolysis in the presence of many chromosomally mediated and plasmid-mediated β-lactamases, such as the Pseudomonas -specific enzymes, which appear to be most prevalent in P. aeruginosa isolates. (medscape.com)
  • In late 2016, the P&T Antimicrobial Subcommittee identified aztreonam as an area where inappropriate prescribing was likely high throughout the facility given that this antimicrobial has less than optimal susceptibility to Pseudomonas aeruginosa on the facility's antibiogram. (cdc.gov)
  • Aztreonam has strong activity against susceptible Gram-negative bacteria, including Pseudomonas aeruginosa. (wikipedia.org)
  • Acinetobacter anitratus, Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis are generally susceptible to aztreonam, while some staphylococci, Staphylococcus aureus, Staphylococcus haemolyticus and Xanthomonas maltophilia are resistant to it. (wikipedia.org)
  • Aztreonam exhibits potent and specific activity in vitro against a wide spectrum of gram-negative aerobic pathogens including Pseudomonas aeruginosa . (genelabs.com)
  • The team discovered this ability after combining EGCG with aztreonam, an antibiotic commonly used to fight off infections caused by Pseudomonas aeruginosa . (naturalnews.com)
  • To determine the activity of murepavadin in comparison with tobramycin, colistin and aztreonam, against cystic fibrosis (CF) Pseudomonas aeruginosa isolates growing in biofilms. (physiciansweekly.com)
  • Urine culture shows pseudomonas aeruginosa bacteria Aztreonam, cefuroxime and cefuroxime shows resistant zone size 6 mm And ultra sound kub shows mild diffuse urinary bladder wall thickening Previously VUR GRADE 5 REFLUX operation done Please suggest complete prevention of recurrent UTI Do you have a fever? (lybrate.com)
  • Aztreonam injection is used to treat certain infections that are caused by bacteria, including respiratory tract (including pneumonia and bronchitis), urinary tract, blood, skin, gynecological, and abdominal (stomach area) infections, that are caused by bacteria. (medlineplus.gov)
  • Aztreonam injection also may be used before, during, and sometimes for a brief period after surgery in order to prevent the patient from getting an infection. (medlineplus.gov)
  • Aztreonam injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). (medlineplus.gov)
  • How often you receive aztreonam injection and the length of your treatment depends on the type of infection you have and how your body responds to the medication. (medlineplus.gov)
  • Your doctor will tell you how long to use aztreonam injection. (medlineplus.gov)
  • You may receive aztreonam injection in a hospital, or you may use the medication at home. (medlineplus.gov)
  • If you will be using aztreonam injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
  • You should begin to feel better during the first few days of treatment with aztreonam injection. (medlineplus.gov)
  • Use aztreonam injection until you finish the prescription, even if you feel better. (medlineplus.gov)
  • Aztreonam injection is also sometimes used to treat patients who have fever and are at high risk for infection because they have a low number of white blood cell. (medlineplus.gov)
  • If you become pregnant while using aztreonam injection, call your doctor. (medlineplus.gov)
  • Aztreonam injection may cause side effects. (medlineplus.gov)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of aztreonam for injection and other antibacterial drugs, aztreonam for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Aztreonam for Injection, USP contains the active ingredient aztreonam, a monobactam. (nih.gov)
  • Aztreonam for Injection is a sterile, nonpyrogenic, sodium-free, lyophilized, off-white to slightly yellowish solid, containing approximately 780 mg arginine per gram of aztreonam. (nih.gov)
  • After identical single intravenous or intramuscular doses of aztreonam for injection, the serum concentrations of aztreonam are comparable at 1 hour (1.5 hours from start of intravenous infusion) with similar slopes of serum concentrations thereafter. (nih.gov)
  • All of the above doses of aztreonam for injection result in average urine levels of aztreonam that exceed the MIC 90 for the same pathogens for up to 12 hours. (nih.gov)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of Aztreonam for Injection, USP and other antibacterial drugs, aztreonam for injection should be used only to treat or. (pfizermedicalinformation.com)
  • Aztreonam for Injection may be administered intravenously or by intramuscular injection. (pfizermedicalinformation.com)
  • Aztreonam for Injection Market Status and Trend Report 2016-2030 offers a comprehensive analysis on Aztreonam for Injection industry, standing on the readers? (bloggersbaba.com)
  • falling business confidence, growing panic among the population, and uncertainty about future.This report also analyses the impact of Coronavirus COVID-19 on the Aztreonam for Injection industry. (bloggersbaba.com)
  • Leading Wholesale Distributor of guficol plus injection, ertafic 1gm inj, mnem 1000mg, aztreonam 1gm injection, bihepenem injection and guficol from Pune. (janwamedical.com)
  • Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from Chromobacterium violaceum . (genelabs.com)
  • Aztreonam, a synthetic monobactam originally isolated as SQ 26,180 from Chromobacterium violaceum, is the first clinically used monobactam. (kegg.jp)
  • Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. (cayston.com)
  • Ceftaroline fosamil ( ZINFORO ® ) 600 mg q12h demonstrated comparable efficacy versus vancomycin plus aztreonam 1 g q12h in terms of clinical cure rates. (pfizerpro.in)
  • Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection. (pfizerpro.in)
  • Dryden M, Zhang Y, Wilson D, Iaconis JP, Gonzalez J. A Phase III, randomized, controlled, non-inferiority trial of ceftaroline fosamil 600 mg every 8 h versus vancomycin plus aztreonam in patients with complicated skin and soft tissue infection with systemic inflammatory response or underlying comorbidities. (pfizerpro.in)
  • Approval of the updated label was based on data from two studies comparing patients with ABSSSI treated with ceftaroline fosamil monotherapy or vancomycin plus aztreonam , the company said. (medscape.com)
  • The activity of inhaled aztreonam extends broadly across susceptible gram-negative aerobic bacteria, including P. aeruginosa . (medscape.com)
  • All 31(100%) P. aeruginosa isolates were sensitive to colistin and polymixin B, while 30 (96.8%) isolates showed sensitivity to piperacillin-tazobactam, cefoperazone-sulbactam and aztreonam. (jacmjournal.org)
  • The combination of aztreonam and avibactam has demonstrated to be active against 80% of MBL isolates reaching a clinical infection resolution in 80% of MBL-infected patients. (wikipedia.org)
  • All isolates were resistant to aztreonam and two isolates were resistant to tigecycline. (who.int)
  • Staphylococcus aureus 8 - >128 μg/ml Staphylococcus epidermidis 8 - 32 μg/ml Streptococcus pyogenes 8 - ≥128 μg/ml Synergism between aztreonam and arbekacin or tobramycin against P. aeruginosa has been suggested. (wikipedia.org)
  • Aztreonam can be safely used in patients with a penicillin or cephalosporin allergy (except for patients with a ceftazidime allergy as ceftazidime and aztreonam share a similar side chain). (wikipedia.org)
  • You must check to make sure that it is safe for you to take aztreonam with all of your drugs and health problems. (medicine.com)
  • Use aztreonam after other breathed in drugs. (medicine.com)
  • Gilead Sciences has investigated the use of the Respiratory Domain of the Quality of Life Questionnaire-Bronchiectasis (QOL-B) in evaluating patients taking inhaled aztreonam, a drug used to treat cystic fibrosis lung infections. (rtmagazine.com)
  • Aztreonam is used in some people with cystic fibrosis to make breathing better. (medicine.com)
  • Aztreonam-Avibactam Susceptibility Testing Program for Metallo-Beta-Lactamase-Producing Enterobacterales in the Antibiotic Resistance Laboratory Network, March 2019 to December 2020. (cdc.gov)
  • Fifty-seven patients, twenty-six males and thirty-one females, aged 6 to 50 years (mean 12.6 years) with proven Salmonella typhi or S. paratyphi A septicaemia, were treated in an open randomized parallel study with either aztreonam or chloramphenicol. (unthsc.edu)
  • Only one patient on aztreonam relapsed following treatment, whereas three patients relapsed after chloramphenicol treatment. (unthsc.edu)
  • Additional data were also presented comparing tigecycline with vancomycin/aztreonam in the treatment of cSSI. (drugtopics.com)
  • In these circumstances aztreonam is combined with avibactam (ceftazidime/avibactam). (wikipedia.org)
  • Assessing the in vitro impact of ceftazidime on aztreonam/avibactam susceptibility testing for highly resistant MBL-producing Enterobacterales. (cdc.gov)
  • When aztreonam is given intramuscularly, it is injected into the muscles of the buttocks or thighs. (medlineplus.gov)
  • Aztreonam was given intramuscularly at a level of 50 to 80 mg/kg body weight per dose every 8 h for 7 days to thirty patients. (unthsc.edu)
  • Aztreonam maintains its antimicrobial activity over a pH range of 6 to 8 in vitro, as well as in the presence of human serum and under anaerobic conditions. (genelabs.com)
  • Each dose of aztreonam for inhalation solution consists of a 2 mL vial of sterile, lyophilized powder that contains 75 mg of aztreonam. (rxhealthmed.ca)
  • Those who are allergic to other β-lactam have a low rate of allergy to aztreonam. (wikipedia.org)
  • Interestingly, i.v. aztreonam exhibits little to no "inoculum effect" in P. aeruginosa infections. (medscape.com)
  • Synergy has been observed when aztreonam is coadministered with an aminoglycoside in P. aeruginosa infections, likely due to complementary mechanisms of action. (medscape.com)
  • Aztreonam use has been recently reconsidered for human infections sustained by metallo-beta-lactamase (MBL)-producing Gram-negative bacteria. (wikipedia.org)
  • When aztreonam is injected intravenously, it is usually infused (injected slowly) over a period of 20 minutes to 1 hour. (medlineplus.gov)
  • The bactericidal action of aztreonam results from the inhibition of bacterial cell wall synthesis due to a high affinity of aztreonam for penicillin binding protein 3 (PBP3). (genelabs.com)
  • and Streptococcus pyogenes have developed resistance to aztreonam to varying degrees. (wikipedia.org)
  • This particular variety -- the NDM-1s have varied slightly in their resistance patterns -- was susceptible to only a single drug, aztreonam. (wired.com)
  • Resistance to amoxicillin-clavulanic acid (6.3%) and aztreonam (5%) was less commonly detected. (allenpress.com)
  • Aztreonam inhibits cell wall synthesis by blocking peptidoglycan crosslinking to cause bacterial death. (wikipedia.org)
  • By binding to PBP3, aztreonam inhibits the third and last stage of bacterial cell wall synthesis. (genelabs.com)
  • SAN DIEGO - Delafloxacin ( Baxdela™ , Melinta Therapeutics), had similar adverse event (AE) profiles when compared with vancomycin/aztreonam as treatment options in patients with acute bacterial skin and skin structure infection (ABSSSI), according to findings from 2 multicenter double-blind, randomized phase 3 trials presented at IDWeek 2017 . (infectiousdiseaseadvisor.com)
  • Pirazmonam is more active than aztreonam against nonfermentative gram-negative bacteria. (semanticscholar.org)
  • When aztreonam pharmacokinetics were assessed for adult and pediatric patients, they were found to be comparable (down to 9 months old). (nih.gov)
  • In elderly patients, the mean serum half-life of aztreonam increased and the renal clearance decreased, consistent with the age-related decrease in creatinine clearance. (nih.gov)
  • In elderly patients and in patients with impaired renal function, the mean serum half-life of aztreonam increased (4.7 to 6 hours and 2.1 hours, respectively). (genelabs.com)
  • This preparation is contraindicated in patients with known hypersensitivity to aztreonam or any other component in the formulation. (pfizermedicalinformation.com)
  • Investigators evaluated outcomes in patients with ABSSSI who received delafloxacin 300 mg IV every 12 hours, or delafloxacin 300 mg IV every 12 hours for 3 days with a mandatory blinded switch to oral delafloxacin 450 mg every 12 hours, or vancomycin 15 mg/kg IV (actual body weight) with aztreonam between 5 to 14 days. (infectiousdiseaseadvisor.com)
  • In comparison with vancomycin/aztreonam, no increase in fluoroquinolone-associated events was observed in the delafloxacin patients. (infectiousdiseaseadvisor.com)
  • En Égypte, des isolats prélevés sur les tubulures d'appareils d'aspiration et de respiration artificielle (A8) et sur les cuvettes (A7) étaient liés à ceux prélevés chez les patients ayant ces antibiotypes. (who.int)
  • RÉSUMÉ La présente étude visait à caractériser des isolats de P. aeruginosa dans deux unités de soins intensifs en Arabie saoudite et en Égypte. (who.int)
  • The patient was placed on Linezolid, Clindamycin, and Aztreonam. (faoj.org)
  • [ 23 ] I.V. aztreonam is known to have increased minimum inhibitory concentration (MIC) values in the presence of high inoculum of certain β-lactamase-rich gram-negative organisms, including Klebsiella species. (medscape.com)
  • Lung function has gotten worse in some people after taking aztreonam for 28 days. (medicine.com)
  • Have your lung function checked while taking aztreonam. (medicine.com)
  • If you are using several medications, use them in the order of bronchodilator, mucolytic (medication to loosen the mucus in the lung), and aztreonam. (rxhealthmed.ca)
  • In healthy subjects, aztreonam is excreted in the urine about equally by active tubular secretion and glomerular filtration. (genelabs.com)
  • Aztreonam exhibits cross-sensitivity with ceftazidime due to a similar side chain. (wikipedia.org)