Monobactams: Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.beta-Lactamases: Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.Ceftazidime: Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).beta-Lactams: Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.Cephalosporins: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Pseudomonas Infections: Infections with bacteria of the genus PSEUDOMONAS.beta-Lactam Resistance: Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.Cefoperazone: Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.Gram-Negative Bacteria: Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.Klebsiella pneumoniae: Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.Enterobacter: Gram-negative gas-producing rods found in feces of humans and other animals, sewage, soil, water, and dairy products.Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.Azlocillin: A semisynthetic ampicillin-derived acylureido penicillin.Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.Enterobacteriaceae: A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.Enterobacteriaceae Infections: Infections with bacteria of the family ENTEROBACTERIACEAE.CephalosporinaseTobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.Piperacillin: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.Isoelectric Focusing: Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Cefotaxime: Semisynthetic broad-spectrum cephalosporin.Clavulanic Acid: Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.Skin Diseases, Bacterial: Skin diseases caused by bacteria.Klebsiella Infections: Infections with bacteria of the genus KLEBSIELLA.Carbapenems: A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.Thienamycins: Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.Klebsiella: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.Citrobacter: A genus of gram-negative, rod-shaped enterobacteria that can use citrate as the sole source of carbon.Azabicyclo Compounds: Bicyclic bridged compounds that contain a nitrogen which has three bonds. The nomenclature indicates the number of atoms in each path around the rings, such as [2.2.2] for three equal length paths. Some members are TROPANES and BETA LACTAMS.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Amdinocillin: An amidinopenicillanic acid derivative with broad spectrum antibacterial action.Serratia marcescens: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria found in soil, water, food, and clinical specimens. It is a prominent opportunistic pathogen for hospitalized patients.Cephalosporin Resistance: Non-susceptibility of an organism to the action of the cephalosporins.Cefoxitin: A semisynthetic cephamycin antibiotic resistant to beta-lactamase.Serratia Infections: Infections with bacteria of the genus SERRATIA.Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.Enterobacter cloacae: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in water, sewage, soil, meat, hospital environments, and on the skin and in the intestinal tract of man and animals as a commensal.Drug Resistance, Multiple, Bacterial: The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Bacterial Infections: Infections by bacteria, general or unspecified.Ticarcillin: An antibiotic derived from penicillin similar to CARBENICILLIN in action.Kinetics: The rate dynamics in chemical or physical systems.Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Proteus vulgaris: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in soil, fecal matter, and sewage. It is an opportunistic pathogen and causes cystitis and pyelonephritis.Gram-Negative Aerobic Bacteria: A large group of aerobic bacteria which show up as pink (negative) when treated by the gram-staining method. This is because the cell walls of gram-negative bacteria are low in peptidoglycan and thus have low affinity for violet stain and high affinity for the pink dye safranine.Penicillins: A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Gram-Positive Bacteria: Bacteria which retain the crystal violet stain when treated by Gram's method.Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.Clavulanic Acids: Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.Acinetobacter: A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.Aminoglycosides: Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.Conjugation, Genetic: A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.Proteus mirabilis: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is frequently isolated from clinical specimens. Its most common site of infection is the urinary tract.Lactams: Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.Salmonella paratyphi A: A serotype of SALMONELLA ENTERICA that causes mild PARATYPHOID FEVER in humans.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Muramoylpentapeptide Carboxypeptidase: Enzyme which catalyzes the peptide cross-linking of nascent CELL WALL; PEPTIDOGLYCAN.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Penicillanic Acid: A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)Gram-Negative Bacterial Infections: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.Penicillin-Binding Proteins: Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.Bacteria, AerobicChromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.Hexosyltransferases: Enzymes that catalyze the transfer of hexose groups. EC 2.4.1.-.Paratyphoid Fever: A prolonged febrile illness commonly caused by several Paratyphi serotypes of SALMONELLA ENTERICA. It is similar to TYPHOID FEVER but less severe.Sulbactam: A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Bile: An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.Bacterial Proteins: Proteins found in any species of bacterium.Acinetobacter baumannii: A species of gram-negative, aerobic bacteria, commonly found in the clinical laboratory, and frequently resistant to common antibiotics.Infusions, Parenteral: The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.Peptidyl Transferases: Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. There are ribosomal and non-ribosomal peptidyltransferases.Escherichia coli Infections: Infections with bacteria of the species ESCHERICHIA COLI.Colistin: Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.Drug Synergism: The action of a drug in promoting or enhancing the effectiveness of another drug.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Meningitis, Haemophilus: Infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. HAEMOPHILUS INFLUENZAE TYPE B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults.Bacteria, AnaerobicInjections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.Macaca fascicularis: A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.Integrons: DNA elements that include the component genes and insertion site for a site-specific recombination system that enables them to capture mobile gene cassettes.Drug Stability: The chemical and physical integrity of a pharmaceutical product.Penicillinase: A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.Administration, Inhalation: The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.Endocarditis, Bacterial: Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.Cross Infection: Any infection which a patient contracts in a health-care institution.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Drug Resistance, Multiple: Simultaneous resistance to several structurally and functionally distinct drugs.Electrophoresis, Gel, Pulsed-Field: Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.Neisseria gonorrhoeae: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.Penicillin Resistance: Nonsusceptibility of an organism to the action of penicillins.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Bacteriological Techniques: Techniques used in studying bacteria.Genes, Bacterial: The functional hereditary units of BACTERIA.Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Enzyme Induction: An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Mice, Inbred ICRChromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Amino Acid Substitution: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

Effects of antibiotic therapy on Pseudomonas aeruginosa-induced lung injury in a rat model. (1/239)

The effect of antibiotics on the acute lung injury induced by virulent Pseudomonas aeruginosa PA103 was quantitatively analyzed in a rat model. Lung injury was induced by the instillation of PA103 directly into the right lower lobes of the lungs of anesthetized rats. The alveolar epithelial injury, extravascular lung water, and total plasma equivalents were measured as separate, independent parameters of acute lung injury. Four hours after the instillation of PA103, all the parameters were increased linearly depending on the dose of P. aeruginosa. Next, we examined the effects of intravenously administered antibiotics on the parameters of acute lung injury in D-galactosamine-sensitized rats. One hour after the rats received 10(7) CFU of PA103, an intravenous bolus injection of aztreonam (60 mg/kg) or imipenem-cilastatin (30 mg/kg) was administered. Despite an MIC indicating resistance, imipenem-cilastatin improved all the measurements of lung injury; in contrast, aztreonam, which had an MIC indicating sensitivity, did not improve any of the lung injury parameters. The antibiotics did not generate different quantities of plasma endotoxin; therefore, endotoxin did not appear to explain the differences in lung injury. This in vivo model is useful to quantitatively compare the efficacies of parenteral antibiotic administration on Pseudomonas airspace infections.  (+info)

In-vitro effects of a combination of antipseudomonal antibiotics against multi-drug resistant Pseudomonas aeruginosa. (2/239)

We evaluated the in-vitro effects of various combinations of five types of widely used antipseudomonal antibiotics (piperacillin, meropenem, ceftazidime, aztreonam and amikacin) against six Pseudomonas aeruginosa strains that were resistant to each of these antibiotics. Among two-drug combinations, the combinations of two beta-lactam antibiotics inhibited growth of one to three P. aeruginosa strains, while those of one beta-lactam antibiotic and amikacin inhibited growth of two to four strains. Among three-drug combinations, the combinations of three beta-lactam antibiotics inhibited growth of four to five strains, and those of two beta-lactam antibiotics and amikacin inhibited growth of five strains. These results suggest the potential usefulness of a combination of two beta-lactam antibiotics and amikacin or that of three beta-lactam antibiotics in treating multi-drug resistant P. aeruginosa infections.  (+info)

Detection and reporting of organisms producing extended-spectrum beta-lactamases: survey of laboratories in Connecticut. (3/239)

Extended-spectrum beta-lactamases (ESBLs) are enzymes produced in some gram-negative bacilli that mediate resistance to extended-spectrum cephalosporins and aztreonam. They are most common in Klebsiella spp. and Escherichia coli but are present in a variety of Enterobacteriaceae. Resistance mediated by these enzymes can be difficult to detect depending on the antimicrobial agents tested. AmpC beta-lactamases are related to the chromosomal enzymes of Enterobacter and Citrobacter spp. and also mediate resistance to extended-spectrum cephalosporins and aztreonam in addition to cephamycins, such as cefoxitin. Unlike ESBLs, however, AmpC beta-lactamases are not inhibited by clavulanic acid or other similar compounds. To assess the abilities of various antimicrobial susceptibility testing methods to detect ESBLs, we sent three ESBL-producing organisms, one AmpC-producing organism, and a control strain that was susceptible to extended-spectrum cephalosporins to 38 laboratories in Connecticut for testing. Eight (21.0%) of 38 labs failed to detect extended-spectrum cephalosporin or aztreonam resistance in any of the ESBL- or AmpC-producing isolates. Errors were encountered with both automated and disk diffusion methods. Conversely, seven (18.4%) labs categorized at least some of the four resistant isolates as potential ESBL producers and reported the results with the extended-spectrum cephalosporins and aztreonam as resistant as suggested by current National Committee for Clinical Laboratory Standards (NCCLS) guidelines. The percentage of laboratories that failed to detect resistance in the ESBL or AmpC isolates ranged from 23.7 to 31.6% depending on the type of enzyme present in the test organism. This survey suggests that many laboratories have difficulty detecting resistance in ESBL and AmpC-producing organisms and may be unaware of the NCCLS guidelines on modifying susceptibility testing reports for ESBL-producing strains.  (+info)

ampR gene mutations that greatly increase class C beta-lactamase activity in Enterobacter cloacae. (4/239)

The ampC and ampR genes of Enterobacter cloacae GN7471 were cloned into pMW218 to yield pKU403. Four mutant plasmids derived from pKU403 (pKU404, pKU405, pKU406, and pKU407) were isolated in an AmpD mutant of Escherichia coli ML4953 by selection with ceftazidime or aztreonam. The beta-lactamase activities expressed by pKU404, pKU405, pKU406, and pKU407 were about 450, 75, 160, and 160 times higher, respectively, than that expressed by the original plasmid, pKU403. These mutant plasmids all carried point mutations in the ampR gene. In pKU404 and pKU405, Asp-135 was changed to Asn and Val, respectively. In both pKU406 and pKU407, Arg-86 was changed to Cys. The ease of selection of AmpR mutations at a frequency of about 10(-6) in this study strongly suggests that derepressed strains, such as AmpD or AmpR mutants, could frequently emerge in the clinical setting.  (+info)

Penicillin binding protein 5 affects cell diameter, contour, and morphology of Escherichia coli. (5/239)

Although general physiological functions have been ascribed to the high-molecular-weight penicillin binding proteins (PBPs) of Escherichia coli, the low-molecular-weight PBPs have no well-defined biological roles. When we examined the morphology of a set of E. coli mutants lacking multiple PBPs, we observed that strains expressing active PBP 5 produced cells of normal shape, while mutants lacking PBP 5 produced cells with altered diameters, contours, and topological features. These morphological effects were visible in untreated cells, but the defects were exacerbated in cells forced to filament by inactivation of PBP 3 or FtsZ. After filamentation, cellular diameter varied erratically along the length of individual filaments and many filaments exhibited extensive branching. Also, in general, the mean diameter of cells lacking PBP 5 was significantly increased compared to that of cells from isogenic strains expressing active PBP 5. Expression of cloned PBP 5 reversed the effects observed in DeltadacA mutants. Although deletion of PBP 5 was required for these phenotypes, the absence of additional PBPs magnified the effects. The greatest morphological alterations required that at least three PBPs in addition to PBP 5 be deleted from a single strain. In the extreme cases in which six or seven PBPs were deleted from a single mutant, cells and cell filaments expressing PBP 5 retained a normal morphology but cells and filaments lacking PBP 5 were aberrant. In no case did mutation of another PBP produce the same drastic morphological effects. We conclude that among the low-molecular-weight PBPs, PBP 5 plays a principle role in determining cell diameter, surface uniformity, and overall topology of the peptidoglycan sacculus.  (+info)

Differential responses of Escherichia coli cells expressing cytoplasmic domain mutants of penicillin-binding protein 1b after impairment of penicillin-binding proteins 1a and 3. (6/239)

Penicillin-binding protein 1b (PBP1b) is the major high-molecular-weight PBP in Escherichia coli. Although it is coded by a single gene, it is usually found as a mixture of three isoforms which vary with regard to the length of their N-terminal cytoplasmic tail. We show here that although the cytoplasmic tail seems to play no role in the dimerization of PBP1b, as was originally suspected, only the full-length protein is able to protect the cells against lysis when both PBP1a and PBP3 are inhibited by antibiotics. This suggests a specific role for the full-length PBP1b in the multienzyme peptidoglycan-synthesizing complex that cannot be fulfilled by either PBP1a or the shorter PBP1b proteins. Moreover, we have shown by alanine-stretch-scanning mutagenesis that (i) residues R(11) to G(13) are major determinants for correct translocation and folding of PBP1b and that (ii) the specific interactions involving the full-length PBP1b can be ascribed to the first six residues at the N-terminal end of the cytoplasmic domain. These results are discussed in terms of the interactions with other components of the murein-synthesizing complex.  (+info)

Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study. (7/239)

Linezolid, the first oxazolidinone, is active against gram-positive bacteria, including multidrug-resistant strains. This multinational, randomized, double-blind, controlled trial compared the efficacy, safety, and tolerability of linezolid with vancomycin in the treatment of nosocomial pneumonia. A total of 203 patients received intravenous linezolid, 600 mg twice daily, plus aztreonam, and 193 patients received vancomycin, 1 g intravenously twice daily, plus aztreonam for 7-21 days. Clinical and microbiological outcomes were evaluated at test of cure 12-28 days after treatment. Clinical cure rates (71 [66.4%] of 107 for linezolid vs. 62 [68.1%] of 91 for vancomycin) and microbiological success rates (36 [67.9%] of 53 vs. 28 [71.8%] of 39, respectively) for evaluable patients were equivalent between treatment groups. Eradication rates of methicillin-resistant Staphylococcus aureus and safety evaluations were similar between treatment groups. Resistance to either treatment was not detected. Linezolid is a well-tolerated, effective treatment for adults with gram-positive nosocomial pneumonia.  (+info)

SHV-27, a novel cefotaxime-hydrolysing beta-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital. (8/239)

From a collection of cefotaxime-resistant Klebsiella pneumoniae isolated from neonatal blood culture specimens in a maternity hospital in Aracaju, Brazil, two isolates (strains KPBRZ-842 and -843, indistinguishable by pulsed-field gel electrophoresis) were found to produce beta-lactamases with isoelectric points (pI) of 5.4 and 8.2, respectively. Using a gel overlay method, cefotaxime hydrolysis was shown to be associated with the pI 8.2 protein. Nucleotide sequencing of the gene encoding the pI 8.2 beta-lactamase revealed a bla(SHV-ESBL)-type gene differing from the gene encoding SHV-1 by three silent point mutations, and a fourth that resulted in an amino acid substitution, aspartate for glycine, at position 156. This novel SHV-type extended-spectrum beta-lactamase is designated SHV-27.  (+info)

This program is to provide expanded access to aztreonam lysine for inhalation (AZLI) prior to its commercial availability to patients with cystic fibrosis (CF)
commit 9c3d34ca4db43e65b51407450b01d934df0821c2 Author: Stefan Schmidt ,[email protected], Date: Tue Apr 26 10:30:50 2016 +0200 docs: evas: description for various surface classes Describing surfaces classes for Wayland, TBM and X11. --- src/lib/evas/canvas/efl_canvas_surface_tbm.eo , 2 ++ src/lib/evas/canvas/efl_canvas_surface_wayland.eo , 2 ++ src/lib/evas/canvas/efl_canvas_surface_x11.eo , 2 ++ 3 files changed, 6 insertions(+) diff --git a/src/lib/evas/canvas/efl_canvas_surface_tbm.eo b/src/lib/evas/canvas/efl_canvas_surface_tbm.eo index 9d16dc8..546cb21 100644 --- a/src/lib/evas/canvas/efl_canvas_surface_tbm.eo +++ b/src/lib/evas/canvas/efl_canvas_surface_tbm.eo @@ -1,5 +1,7 @@ class Efl.Canvas.Surface_Tbm (Efl.Canvas.Surface) { + [[Native Tizen Buffer Manager surface for Efl canvas]] + legacy_prefix: null; implements { Eo.Base.constructor; diff --git a/src/lib/evas/canvas/efl_canvas_surface_wayland.eo b/src/lib/evas/canvas/efl_canvas_surface_wayland.eo index 9cf9114..4734ef0 100644 --- ...
canvas is a reference to a ,canvas, element var context = canvas.getContext(2d); context.fillRect(0,0,50,50); canvas.setAttribute(width, 300); // clears the canvas context.fillRect(0,100,50,50); canvas.width = canvas.width; // clears the canvas context.fillRect(100,0,50,50); // only this square ...
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On 2/3/10 1:01 PM, Tim Hutt wrote: , Good point, it would be better to call it onresize for consistency. , So my revised suggestion is: , , 1. Support more length specifiers for the width and height of a , canvas(%, em, etc.). , 2. Add an onresize event to the canvas tag. When the canvas is resized , it is reset and this event is fired. , 3. CSS size specifiers resize rather than scale the canvas. I.e. it , should always be that 1 unit = 1 pixel initially. #3 would break existing canvas content. #2 would work if all elements supported onresize (as has been proposed), right? Given that, a resize handler could simply reset the canvas width/height attrs if desired (thereby achieving #1 and the clearing aspect of #2), no? Hence my question: what use cases here would not be covered simply by having a general resize event on all elements? -Boris ...
In reply to comment #6) , (From update of attachment 43541 [details]) , I leave the final review to Ollie, but here is my take: , , , Index: WebCore/WebCore.gypi , , =================================================================== , , --- WebCore/WebCore.gypi (revision 51226) , , +++ WebCore/WebCore.gypi (working copy) , , @@ -1271,6 +1271,20 @@ , , history/HistoryItem.h, , , history/PageCache.cpp, , , history/PageCache.h, , , + html/canvas/CanvasGradient.cpp, , , + html/canvas/CanvasGradient.h, , , + html/canvas/CanvasObject.cpp, , , + html/canvas/CanvasObject.h, , , + html/canvas/CanvasPattern.cpp, , , + html/canvas/CanvasPattern.h, , , + html/canvas/CanvasPixelArray.cpp, , , + html/canvas/CanvasPixelArray.h, , , + html/canvas/CanvasRenderingContext.cpp, , , + html/canvas/CanvasRenderingContext.h, , , + html/canvas/CanvasRenderingContext2D.cpp, , , + html/canvas/CanvasRenderingContext2D.h, , , + html/canvas/CanvasStyle.cpp, , , + html/canvas/CanvasStyle.h, ...
PS - Ingenieros. Programación y realización del Taller de Canvas Entrega de Canvas de los colaboradores Programar junta con jefe directo a cada uno de los puestos para presentar y discutir su Canvas Programar segunda cita con proveedores y clientes internos de cada puesto para presentar su Canvas D.O. recolecta todos los Canvas y los integra a los perfiles de puesto de cada empresa ETAPA 1 ETAPA 3 ETAPA 2 2002 March Colaboradores generan Canvas de su puesto Presentar qué es y cómo hacer un ...
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It was a remarkable day yesterday. In spite of new guidance (still flawed in my view) on clinical trial design in pneumonia and in skin infections, the FDA review of the data developed under the old guidelines by Cerexa/Forest for ceftaroline was balanced and informative. The incredibly tight data and very well designed studies saved the day. Not only did the ceftaroline data, with studies powered for a 10% NI margin, come in at 4 or 5% overall, but almost all of the subgroup analyses carried out by both the sponsor and the FDA (and some of these subgroups were small!!) came in with NI margins under 10% compared to either ceftriaxone in the pneumonia studies or vancomycin plus aztreonam in the skin infection studies. But in addition, the spectacular data allowed the FDA to accept studies carried out under an old paradigm and to use a post-hoc approach to examine putative new endpoints in an exploratory way. I discussed the idea to use this approach with the FDA back in April. ...
My mother did a crayon painting on canvas (24 X 36)years ago. She just moved to a smaller place and gave it to a friend. She used shaved crayons, covered the areas of the canvas with wax paper and used a warm iron. I wish I had a picture to show you; it looked like a crystal cave, full of beautiful colored patterns. I was in the process of shaving some crayons when I decided to look up this form of art on the web. Im glad to see it is still done. Nice work Jenna and Matthew!I really like the fact that you left some of the white canvas show. I bet a black gessoed canvas would not look too bad either. I am going to Walmart today and Im going to buy a wand type mini iron; the head is triangular so it might work well on a smaller canvas. I will let you know the results. The skys the limit! Diane from Kamloops, BC Canada. ReplyDelete ...
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html, ,head, ,script, // A canvas demo by Kas Thomas. // http://asserttrue.blogspot.com // Use as you will, at your own risk. context = null; canvas = null; window.onload = function(){ canvas = document.getElementById("myCanvas"); canvas.addEventListener(mousemove, handleMousemove, false); context = canvas.getContext("2d"); loadHiddenText(); } function loadHiddenText( ) { var options = document.getElementsByTagName( "option" ); var spans = document.getElementsByTagName( "span" ); for (var i = 0; i , options.length; i++) options[i].value = spans[i].innerHTML; } // should probably be called resetCanvas() function clearImage( ) { canvas.width = canvas.width; } function drawViaCallback( ) { var w = canvas.width; var h = canvas.height; var canvasData = context.getImageData(0,0,w,h); for (var idx, x = 0; x , w; x++) { for (var y = 0; y , h; y++) { // Index of the pixel in the array idx = (x + y * w) * 4; // The RGB values var r = canvasData.data[idx + 0]; var g = canvasData.data[idx + 1]; var b = ...
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The Bradley Canvas watch brings a subtle casual look to the collection while maintaining the same elegant and minimalist design of the Bradley series. Created by Eone Time, the watch transforms the classic watch design into a revolutionary product that can be worn by everyone, from sighted to visually impaired users. The two magnetic ball bearings travel on two separate tracks and signal the hour and minute; they correspond to the raised hour markers on the front, allowing the user to quickly tell the time using the sense of touch. This innovative feature also makes the Bradley Canvas a great choice for those who wish to check the time discreetly. Made with a titanium case, the watches have a high quality Swiss movement and a Renata 371 button cell watch battery. The dyed canvas straps feature a soft leather interior and are available in six colors: aqua, olive, mustard, crimson, beige, and noir.. Read More ...
Compared to Moto G, HTC Desire 516, Blackberry Z3, Canvas Nitro has superb features. Canvas Nitro is powered by 1.7 GHz Tru-Octacore processor along with Android Kitkat 4.4.2 operating system, 2 GB RAM and 8 GB internal memory of which 5.68 GB will be available for apps and mass storage. Canvas Nitro A310 also comes with a microSD card slot which can further expand the memory by 32 GB. 2 GB RAM makes the device more capable for playing games and watching movies at the same time.
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canvas id="myCanvas" width="600" height="600", Your user agent does not support the HTML5 Canvas element. ,/canvas, ,script, var myCanvas = document.getElementById("myCanvas"); var ctx = myCanvas.getContext("2d"); var w = myCanvas.width, h = myCanvas.height; var i = 0; do { ctx.fillStyle = "rgb(" + Math.round(255*Math.random()) + "," + Math.round(255*Math.random()) + "," + Math.round(255*Math.random()) + ")"; ctx.beginPath(); ctx.arc(w*Math.random(), h*Math.random(), 50*Math.random(), 0, Math.PI*2, true); ctx.closePath(); ctx.fill(); } while (++i != 1000); ,/script ...
Browse Canvas Art Blue Coastal wall art - 43 available at Lamps Plus! 120% low price protection guarantee - Shell On White 4-Piece 12&Quot; Square Canvas Wall Art Set, Mykonos 40&Qu...
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Ideal for stretched canvas, these Premium Stretched Protective Closure Canvas Bags are thicker and stronger, while retaining their crystal clarity. PC1624A
... - Mixed media collage on 8x8 canvas board. I feel like its missing something, but I always feel that way so I probably wont add anythi
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Heres a great way to show off your favorite photo--or you could create a wedding, graduation or Fathers Day gift! Get a 12 x 12 High Quality Photo Canvas For Only $20 (Save $24.99). Use Coupon Code: YORK12CANVAS at checkout through 5/10. Youll also get 40 FREE photo prints with this offer. For more deals check out MomsWhoSave anytime.
Create your own premium 20x30 canvas from CVS Photo. Canvas prints make the perfect display for wedding photos, scenery and more. FREE ship to store available!
Stamp flowers and leaves with gray on tissue paper. Color with Copic markers. Tear around edge of design. Brush small amount of Fast Finish over area to place flower/tissue. Place colored tissue down on the wet surface. Brush another thin layer carefully over the tissue piece to seal and adhere to the canvas. Apply a light coat over entire canvas as well ...
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This months craft will be a 12x12 canvas, featuring a painted map of Cape Cod with a heart in your favorite place. A perfect decoration for Valentines Day or any time! All materials will be supplied and full instruction will be given to guide you through the entire project. Canvases will be completed to take home that night.
LA CANVAS - THE FASHION ISSUE (SEPTEMBER / OCTOBER 2013): DOMINC LORD, 2 LIVE CREW, SPIROS HALARIS, MARCELA GUTIERREZ, PUBLIC SCHOOL, THE DRESLYN, ARI TAYMOR, EBANOS CROSSING, MICHAEL CARDENAS, LEICA GALLERY LA, STREET ART, EVENTS CALENDAR, FASHION E...
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Buy Garden Snail as a printed wall art in giclée, canvas or framed print format. Discover the perfect print, canvas or photo for your space with Picfair Prints.
Free shipping and returns on iCanvas Skull 2 by Ali Gulec Giclée Print Canvas Art at Nordstrom.com. |p|Add brilliant color and exceptional detail to your living space with a giclée canvas reproduction of Ali Gulecs painting Skull 2. Crafted in the USA, the piece is hand stretched and stapled over pinewood bars, while fade-resistant archival ink guarantees perfect color reproduction, so your art will remain vibrant for decades, even when exposed to strong light.|/p|
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High quality Haku Japan inspired Canvas Prints by independent artists and designers from around the world. Independent art hand stretched around super sturdy wood frames. Printed with durable, fade-resistant inks. Turn your home, office, or studio into an art gallery, minus the snooty factor. All orders are custom made and most ship worldwide within 24 hours.
Compatible: Apple iPad 2 SwitchEasy has listened to their customers needs from day one. CANVAS for iPad 2 is the natural evolution to their successful folio line for iPad 2. Following previous tradition, they have employed a special water resistant
RH Baby & Childs Cotton Canvas Drapery Panel:Double-yarn weave gives these lush cotton-canvas panels excellent weight and drape.
Rubbing alcohol and Borax can be used to remove mildew on washable canvas surfaces. White vinegar can also be used to remove mildew and deodorize...
On 07/06/2008, Ondřej Žižka ,ondra at dynawest.cz, wrote: , Hi, , , Ive been looking for something similar to OpenGLs selection buffer - that is, you can get some object ID for the given coordinates. , , E.g., Jacob Seidelins chess game http://blog.nihilogic.dk/search/label/chess could use it, but instead, keyboard control had to be used. , , isPointInPath() does not solve the problem effectively if the path would be too complex - e.g. pixel-based sprites in several layers. , , For an example of what I want to implement, see e.g. , http://www.openttd.org/screens.php?image=images/screens/0.5.0/japan_national_railway_3_aug_1984 . , Mathematical computation of the object is principially impossible (or too complex in best case). To hande sprites, you could draw each sprite onto its own canvas (during the initial loading process) and test spriteCtx.getImageData(x, y, 1, 1).data[3] , 127 to see if its sufficiently non-transparent. Quickly skip any sprites whose bounding box does not contain ...
i was doing the dishes, enjoying the view of the river as the sun was setting ... tonights sunset was so lovely that i wanted to try and capture the beauty ... even braving a possible meeting with our neighbourhood black bear! so i grabbed my camera and ran to the backyard ... i snapped away ... this is one of the scenes that i was blessed to view ... of course, i had to share it with you all ... *smile* ... Gods canvas and art is the best! dontcha think? ...
These Cotton Canvas Window Panels offer a simple, accessible way to dress up windows in a color that easily coordinates with any interior. As a Fair Trade Certified™ product, each piece made directly supports the workers behind it. • 10…
Never lose your lunch again with this custom canvas handle lunch bag.12.5 x 8x 5.5 canvasRoll to close with secure velcroPhthalate, BPA and Lead-Free
An anonymous reader writes Over on the IE blog they have a rundown of IE9s hardware accelerated support for the canvas element. They write, With the recent release of the latest IE9 platform preview, we talked about how were rebuilding the browser to use the power of your whole PC to browse the ...
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The Cygnett Alumni is covered with classic hard-wearing canvas fabric that protects the new iPad from wear and tear. Opening or closing the case automatically activates the sleep/wake function, while concealed magnets keep the case securely closed.
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Cotton canvas is stretched over a sturdy wooden frame. Each print is individually stretched and constructed for your order. Starting at $59
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Explore maheen bukharis board second year on Pinterest. | See more ideas about Canvas walls, Chalets and Environmental design.
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Finally the Micromax Canvas 4 pre-booking link is now active on the MMX website. Interestingly Micromax has not yet disclosed any details about the new han
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Devon Govett씨는 자바스크립트와 HTML5의 Canvas API를 이용하여 사진에서 얼굴을 발견하는 프로그램을 작성했습니다. iPhoto나 ... (이 페이지는 기간 2011, 태그 자바스크립트, 범주 자료(으)로 필터링 되었습니다.)
By submitting this form, you agree that all information on Fireside Distributors Exclusive Dealer Site is confidential and intended for authorized Fireside Distributors Dealer use only.. ...
Working on my black gessoed canvas. I stretched it yesterday and within minutes of starting, I take the prepped canvas off the bars, for ease in working. Right now, Im calling this a sketch. I had no plans to draw out a torso, but when last week, I completed the construction of the head and limbs…
Electrode, Comp-185576001, DC-prod-dal1, ENV-prod-a, PROF-PROD, VER-4.19.0, SHA-0d3d75eca30cbeee0c86c41db749e9fc9f3b1c0d, CID ...
Immunity Partners program updates are now available to all customers as CANVAS Early Updates. Further information on the CANVAS Early Updates program can be found here.. Contact us at [email protected] for more information.. ...
Electrode, Comp-293317480, DC-prod-dal4, ENV-prod-a, PROF-PROD, VER-4.19.0, SHA-0d3d75eca30cbeee0c86c41db749e9fc9f3b1c0d, CID ...
You simply wont find another bag as essential as this one. Our tote is an example of how the details truly make all the difference. It is held together by felled seams to help the tote stay upright, even when you set it down. The ultra-strong canvas doubles the durability factor on the bottom and in the handles. Plus, this tote has places for absolutely everything you need to bring along. Once you own one, youll want several, all monogrammed for their specific purposes. ...
|p||a title=Picture Porefect href=http://www.dermadoctor.com/picture-porefect-pore-minimizing-solution.html||strong|Picture Porefect|/strong||/a||br /|Perfect your pores and create a canvas of flawless skin.  Picture Porfect helps refine and tigh
Speaking truth that matters with whatever medium necessary. Original watercolors on canvas and paper, as well as limited edition doodle prints!
Constriction I, a Paper Collage on Canvas, by Gustavo Ortiz from United Kingdom, Not for sale, Price is $, Size is 13.8 x 9.8 x 0.7 in.
Prototype과 Canvas태그를 이용해서 매우 간결하게 만든 Polar 시계이다. 이 예제는 시간을 색다르게 비주얼라이제이션하고 있... (이 페이지는 기간 2008-03, 태그 project(으)로 필터링 되었습니다.)
Cure: Total resolution of all signs and symptoms of the baseline infection, or improvement of the infection such that no further antimicrobial therapy was necessary.. Failure: Requirement of alternative antimicrobial therapy for primary infection of complicated skin and skin structure infection (cSSSI) due to inadequate response, recurrence, new infection at the same site; treatment-limiting adverse event (AE); requirement for surgery due to failure of study drug; diagnosis of osteomyelitis after Study Day 8; or death caused by cSSSI.. Indeterminate: Inability to determine an outcome ...
Ceftaroline fosamil is a new drug in development for the treatment of community acquired bacterial pneumonia and complicated skin and skin structure infections. Ceftaroline fosamil information includes news, clinical trial results and side effects.
FOSTER CITY, Calif. & SEATTLE, Apr 12, 2006 (BUSINESS WIRE) -- Gilead Sciences, Inc. (Nasdaq:GILD) and Corus Pharma, Inc. today announced that Gilead has invested $25 million in Corus, a privately-held Seattle-based company focused on the development of novel drugs for respiratory diseases. In return for the investment, Gilead will receive preferred shares in Corus and will become the second largest shareholder in the company. Gilead will also have an exclusive option to purchase the remaining shares of Corus at a pre-specified price. Corus lead product candidate, Cayston(TM) (aztreonam lysine for inhalation), is an inhaled antibiotic with activity against gram-negative bacteria including Pseudomonas aeruginosa, which can cause lung infections in patients with cystic fibrosis (CF). Corus is currently enrolling Phase III studies to evaluate the product as a potential treatment for CF-related pulmonary infections. Aztreonam lysine for inhalation was granted orphan drug status by the U.S. Food & ...
Reproductions of original artwork have been printed on canvas for many decades using offset printing. Since the 1990s, canvas print has been also been associated with either dye sublimation or inkjet print processes (often referred to as repligraph or giclée[1] respectively). The canvas print material is generally cotton or plastic based poly canvas, often used for the reproduction of photographic images. Digital printers capable of producing canvas prints range from small consumer printers owned by the artist or photographer themselves up to large format printing service printers capable of printing onto canvas rolls measuring 1.5 metres (59 in) or more. Digital files of artwork, paintings, photograph, or drawings may be sent directly to printing companies or Internet based printing services. ...
... Canvases Art Supplies. Utrecht Traditional Acrylic Primed Cotton Canvas Rolls feature 10 oz 100 procent cotton duck primed with 3 coats of acrylic gesso to reach a 14 oz finished The medium
this listing is for a zipper tote bag made from waxed canvas top portion made from charcoal waxed canvas that has blue undertones and the bottom portion with dark oak coloured waxed canvas, with handles made from leather in a beautiful dark brown colour FABRIC INFO: this waxed canvas is weather resistant and has a nice
...   Made in the USA   Made of durable cotton canvas, the Six Panel Canvas Skull Cap Beanie Hat has the classic dome-hugging skull cap look and feel in a hard-wearing and natural material. Featuring their classic six-panel ...
define __SP_CANVAS_ACETATE_C__ /* * Infinite invisible canvas item * * Author: * Federico Mena ,[email protected], * Raph Levien ,[email protected], * Lauris Kaplinski ,[email protected], * * Copyright (C) 1998-1999 The Free Software Foundation * Copyright (C) 2002 Lauris Kaplinski * * Released under GNU GPL, read the file COPYING for more information */ #include "display-forward.h" #include "gnome-canvas-acetate.h" static void sp_canvas_acetate_class_init (SPCanvasAcetateClass *klass); static void sp_canvas_acetate_init (SPCanvasAcetate *acetate); static void sp_canvas_acetate_destroy (GtkObject *object); static void sp_canvas_acetate_update (SPCanvasItem *item, NR::Matrix const &affine, unsigned int flags); static double sp_canvas_acetate_point (SPCanvasItem *item, NR::Point p, SPCanvasItem **actual_item); static SPCanvasItemClass *parent_class; GtkType sp_canvas_acetate_get_type (void) { static GtkType acetate_type = 0; if (!acetate_type) { GtkTypeInfo acetate_info = { ...
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... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
Azactam (aztreonam). *Baraclude (entecavir). *Daklinza (daclatasvir). *Evotaz (atazanavir/cobicistat). *Megace (megestrol ...
J01DF01 Aztreonam. J01DF02 Carumonam. J01DH Karbapenemi. J01DH02 Meropenem. J01DH03 Ertapenem. J01DH04 Doripenem. J01DH05 ...
The drugs that specifically target gram negative organisms include aminoglycosides, monobactams (aztreonam) and Ciprofloxacin. ... Other classes of drugs that have gram negative spectrum include cephalosporins, monobactams (aztreonam), aminogylosides, ...
Currently the only commercially available monobactam antibiotic is aztreonam. Other examples of monobactams are tigemonam, ...
Inhaled therapy with antibiotics such as tobramycin, colistin, and aztreonam is often given for months at a time to improve ... McCoy KS, Quittner AL, Oermann CM, Gibson RL, Retsch-Bogart GZ, Montgomery AB (November 2008). "Inhaled aztreonam lysine for ...
Antipseudomonal penicillins, aminoglycosides, fluoroquinolones, third generation cephalosporins or aztreonam can be given. ...
For penicillin allergic people, aztreonam or a quinolone with metronidazole may be used. In cases of severe inflammation, shock ...
Aztreonam is stable to the metallo-β-lactamases, but many IMP and VIM producers are resistant, owing to other mechanisms. ... These cephalosporins include cefotaxime, ceftriaxone, and ceftazidime, as well as the oxyimino-monobactam aztreonam. Thus ESBLs ... and aztreonam, even if it is tested (in vitro) as susceptible.[citation needed] Associated resistance to aminoglycosides and ... as well as the oxyimino-monobactam aztreonam), but not 7-alpha-methoxy-cephalosporins (cephamycins; in other words, cefoxitin ...
... shares the same variable R-group side chain with aztreonam, a monobactam antibiotic; the two drugs share a similar ...
For penicillin allergic people, aztreonam or a quinolone with metronidazole may be used. ...
Wainwright CE, Quittner AL, Geller DE, Nakamura C, Wooldridge JL, Gibson RL, Lewis S, Montgomery AB (July 2011). "Aztreonam for ...
... and aztreonam. C. hominis is often resistant to erythromycin. Since cefotaxime use may be not appropriate for C. hominis ...
Aztreonam plus metronidazole is an alternative, but addition of an agent effective against gram-positive cocci is recommended. ...
Corus was developing aztreonam lysine for the treatment of patients with cystic fibrosis who are infected with Pseudomonas ...
AZT or azt may also refer to: Azerbaijan Time, a time zone Aztreonam, an antibiotic drug Atta language (ISO 639:azt). ...
E. faecalis is resistant to many commonly used antimicrobial agents (aminoglycosides, aztreonam, cephalosporins, clindamycin, ...
C. violaceum produces a number of natural antibiotics: Aztreonam is a monobactam antibiotic that is active against gram- ... For theoretical reasons, infection would not be expected to respond to penicillins, cephalosporins, or aztreonam, although ...
Vancomycin plus Aztreonam in Complicated Skin and Skin Structure Infections (cSSSI). 2008 Interscience Conference on ... The CANVAS I and CANVAS II trials evaluated ceftaroline monotherapy versus vancomycin plus aztreonam in adult patients with ... skin and skin structure infections with reported non-inferior efficacy against MRSA compared to vancomycin and aztreonam. In ...
... aztreonam, trimethoprim-sulfamethoxazole, ciprofloxacin, nitrofurantoin and the aminoglycosides. Antibiotic resistance is a ...
... aztreonam MeSH D03.383.411.500 --- moxalactam MeSH D03.383.517.200 --- carboxin MeSH D03.383.533.249 --- benzoxazines MeSH ...
carbapenems (meropenem, imipenem, doripenem, but not ertapenem) polymyxins (polymyxin B and colistin) monobactams (aztreonam) ...
... successfully completed phase III trials in which it was at least equal to intravenous vancomycin and aztreonam to ...
... was approved by the FDA in June 2017, after it was noninferior to vancomycin plus aztreonam in two trials on 1042 ...
... among Escherichia coli and Klebsiella isolates with hidden resistance to expanded-spectrum cephalosporins and aztreonam? J. ...
Aztreonam Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... You may receive aztreonam injection in a hospital, or you may use the medication at home. If you will be using aztreonam ... Use aztreonam injection until you finish the prescription, even if you feel better. If you stop using aztreonam injection too ... Before using aztreonam injection,. *tell your doctor and pharmacist if you are allergic to aztreonam, cephalosporins such as ...
As of the 1st Quarter of 2019, the use of aztreonam at the facility has decreased to approximately 10 antimicrobial days per ... A Veterans Affairs (VA) hospital evaluated use of aztreonam by analyzing NHSN Antimicrobial Use (AU) Option data pulled monthly ... Decreasing Aztreonam Use in a Veterans Affairs Hospital. ... the P&T Antimicrobial Subcommittee identified aztreonam as an ... The educational tool also provided guidance for recommending alternatives to aztreonam based on this risk. The facility decided ...
Easy-to-read patient leaflet for Aztreonam (Oral Inhalation). Includes indications, proper use, special instructions, ... What do I need to tell my doctor BEFORE I take Aztreonam?. *If you have an allergy to aztreonam or any other part of aztreonam ... How is this medicine (Aztreonam) best taken?. Use aztreonam (oral inhalation) as ordered by your doctor. Read all information ... Keep taking aztreonam (oral inhalation) as you have been told by your doctor or other health care provider, even if you feel ...
Aztreonam usually results in bacterial death through blocking their ability to make a cell wall. Aztreonam was approved for ... Aztreonam is often used in people who are penicillin allergic or who cannot tolerate aminoglycosides. Aztreonam is poorly ... Aztreonam is bactericidal, but less so than some of the cephalosporins. "Aztreonam". The American Society of Health-System ... Because of the unfused beta-lactam ring unique to aztreonam, there is somewhat lower cross-reactivity between aztreonam and ...
Aztreonam inhalation is used to improve breathing symptoms in people who have cystic fibrosis and a certain bacteria in their ... Aztreonam is an antibiotic that fights severe or life-threatening infection caused by bacteria. ... What is aztreonam?. Aztreonam is an antibiotic that fights severe or life-threatening infection caused by bacteria. ... Before using aztreonam, tell your doctor if you are allergic to any type of antibiotic, especially a cephalosporin (Ceftin, ...
Aztreonam is used to treat severe infections of the blood, urinary tract, lower respiratory tract, skin, stomach, or female ... Aztreonam may also be used for purposes not listed in this medication guide. ... Aztreonam is an antibiotic that fights severe or life-threatening infection caused by bacteria. ... How should I use aztreonam?. Aztreonam is injected into a muscle, or into a vein through an IV. Aztreonam is usually given in a ...
If you have an allergy to aztreonam or any other part of this drug. ...
Easy-to-read patient leaflet for Aztreonam (Systemic). Includes indications, proper use, special instructions, precautions, and ... What do I need to tell my doctor BEFORE I take Aztreonam?. *If you have an allergy to aztreonam or any other part of aztreonam ... How do I store and/or throw out Aztreonam?. *If you need to store aztreonam (systemic) at home, talk with your doctor, nurse, ... How is this medicine (Aztreonam) best taken?. Use aztreonam (systemic) as ordered by your doctor. Read all information given to ...
Detailed drug Information for aztreonam Intravenous, Injection. Includes common brand names, drug descriptions, warnings, side ... Proper Use of aztreonam. To help clear up your infection completely, aztreonam must be given for the full time of treatment, ... Also, aztreonam works best when there is a constant amount in the blood or urine. To help keep the amount constant, aztreonam ... aztreonam is available only with your doctors prescription.. Before Using aztreonam. In deciding to use a medicine, the risks ...
Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from Chromobacterium violaceum. Aztreonam ... Aztreonam Lysine. XNM7LT65NP. 827611-49-4. KPPBAEVZLDHCOK-JHBYREIPSA-N. Prescription Products. Name. Dosage. Strength. Route. ... Aztreonam maintains its antimicrobial activity over a pH range of 6 to 8 in vitro, as well as in the presence of human serum ... Aztreonam. Accession Number. DB00355 (APRD00815, EXPT00605) Type. Small Molecule. Groups. Approved. Description. A monocyclic ...
Aztreonam is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Aztreonam has activity in the ... All of the above doses of aztreonam for injection result in average urine levels of aztreonam that exceed the MIC 90 for the ... Unchanged aztreonam and the inactive beta-lactam ring hydrolysis product of aztreonam were present in feces and urine. ... Aztreonam for Injection, USP contains the active ingredient aztreonam, a monobactam. It was originally isolated from ...
Aztreonam (Oral Inhalation) - Last updated on February 25, 2020. ©2020 Memorial Sloan Kettering Cancer Center. ...
Aztreonam for Inhalation Solution) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, ... Aztreonam exhibits activity in vitro against Gram-negative aerobic pathogens including P. aeruginosa. Aztreonam binds to ... Following administration of aztreonam for injection, aztreonam is excreted in human milk at concentrations that are less than ... Rats were exposed to aztreonam for up to 4 hours per day. Peak plasma levels of aztreonam averaging approximately 6.8 mcg/mL ...
Aztreonam). It is manufactured by Glenmark Pharmaceuticals Ltd.. Find out its price,dose and the nearest pharmacy to buy it. ... Other Aztreonam Brands. Brand Name. Combination Generics. Manufacturers. Type. Azactam (1000 mg) Bristol-Myers Squibb India Pvt ... Trezam (2 gm) (Aztreonam) Price List. Compiled by Lingaraj. Medically Reviewed by The Medindia Medical Review Team on February ... Aztreonam Drug Information This medication is monobactam antibiotic, prescribed for serious infections caused by susceptible ...
Also Known As: Az-threonam; Azactam; Azthreonam; Bristol-Myers Squibb Brand of Aztreonam; Esteve Brand of Aztreonam Show All ,, ... Aztreonam Summary Description: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is ... Key Diseases for which Aztreonam is Relevant. * Infection : 44 outcomes 62 studies in 259 results ...
Inhaled aztreonam (Cayston®) is an antibiotic that has been approved for people with CF who are chronically infected with ...
combination of Aztreonam-Avibactam (ATM-AVI). Drug: combination of Aztreonam - Avibactam (ATM-AVI) PART A: ATM-AVI IV infusion ... Drug: Avibactam (AVI) Drug: Aztreonam (ATM) Drug: combination of Aztreonam - Avibactam (ATM-AVI) Drug: Placebo Phase 1 ... To Investigate the Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI). The safety and scientific validity of this study ... Aztreonam. Avibactam. Anti-Bacterial Agents. Anti-Infective Agents. beta-Lactamase Inhibitors. Enzyme Inhibitors. Molecular ...
Aztreonam for Inhalation (AI) in Patients With Cystic Fibrosis & P. Aeruginosa Infection. This study has been completed. ... A Blinded, Multicenter, Randomized, Placebo-Controlled Trial With Aztreonam for Inhalation (AI) in Cystic Fibrosis Patient With ...
MIC50 and MIC90 of aztreonam for Pseudomonas aeruginosa isolates with the highest MIC from each patient (µg/ml): baseline to ... An 18-month study of the safety and efficacy of repeated courses of inhaled aztreonam lysine in cystic fibrosis.. Oermann CM1, ... AIR-CF3 was an international 18-month, open-label study to evaluate the safety and efficacy of repeated courses of aztreonam ... An 18-Month Study of the Safety and Efficacy of Repeated Courses of Inhaled Aztreonam Lysine in Cystic Fibrosis ...
Use of cephalexin-aztreonam-arabinose agar for selective isolation of Enterococcus faecium.. M Ford, J D Perry, F K Gould ... Cephalexin-aztreonam-arabinose agar (CAA), a new selective agar, was examined in comparison with nalidixic acid-colistin agar ... Use of cephalexin-aztreonam-arabinose agar for selective isolation of Enterococcus faecium. ... Use of cephalexin-aztreonam-arabinose agar for selective isolation of Enterococcus faecium. ...
... What is this medicine?. AZTREONAM (AZ tree oh nam) is a monobactam antibiotic. It is used to treat certain ... an unusual or allergic reaction to aztreonam, other antibiotics or medicines, foods, dyes, or preservatives ...
Aztreonam is used to treat severe infections of the blood, urinary tract, lungs, skin, stomach, or female reproductive organs. ... Aztreonam may also be used for purposes not listed in this medication guide. ... What is aztreonam?. Aztreonam is an antibiotic that fights bacteria.. Aztreonam is used to treat severe infections of the blood ... What should I discuss with my healthcare provider before using aztreonam?. You should not use aztreonam if you are allergic to ...
Aztreonam for Inhalation Solution vs Tobramycin Inhalation Solution in Patients With Cystic Fibrosis & Pseudomonas Aeruginosa. ... Inhaled aztreonam lysine vs. inhaled tobramycin in cystic fibrosis: a comparative efficacy trial. J Cyst Fibros. 2013 Mar;12(2 ... AZLI (75 mg/1 mL aztreonam lysine when reconstituted in diluent [0.17% saline]; sterile, pH 4.2 to 7.0, and osmolality 300 to ... AZLI (75 mg/1 mL aztreonam lysine when reconstituted in diluent [0.17% saline]; sterile, pH 4.2 to 7.0, and osmolality 300 to ...
A Prospective, 5-year Registry Study to Monitor the Susceptibility to Aztreonam of Pseudomonas Aeruginosa (PA) Isolates From ... Registry to Monitor the Susceptibility to Aztreonam of Pseudomonas Aeruginosa Isolates From Cystic Fibrosis Patients (AIR-CF5) ... To determine whether there are any changes in susceptibility to aztreonam among Pseudomonas aeruginosa (PA) isolates from ... Determine whether changes in clinical outcomes are associated with changes in susceptibility of PA isolates to aztreonam. [ ...
Aztreonam for inhalation solution (AZLI; 75 mg aztreonam/52.5 mg lysine monohydrate) was administered three times a day, with ... The purpose of this research study was to determine if an experimental drug called Aztreonam for Inhalation Solution (AZLI) was ... Phase 3b Randomized, Double-Blind, Placebo-Controlled Two-Part Trial to Assess the Safety and Efficacy of Continuous Aztreonam ... Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Patients With Cystic Fibrosis and Chronic Burkholderia ...
  • Determine whether changes in clinical outcomes are associated with changes in susceptibility of PA isolates to aztreonam. (clinicaltrials.gov)
  • however, the numbers of isolates and enzymes studied here were substantially greater, and the investigation included aztreonam-NXL104, which was not studied previously. (asm.org)
  • These carbapenemases remain susceptible to aztreonam, although most MBL-producing isolates also harbour ESBLs or other β-lactamases that confer resistance to aztreonam.4 The combination of aztreonam and avibactam has demonstrated potent in vitro activity against MBL-producing Enterobacteriaceae including those isolates that also carry other β-lactamases.5 However, this combination is currently in clinical development and unavailable for clinical use. (deepdyve.com)
  • Aztreonam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against negative microbial isolates. (discofinechem.com)
  • Appropriate studies have not been performed on the relationship of age to the effects of aztreonam inhalation in children younger than 7 years of age. (drugs.com)
  • Each vial (bottle) of aztreonam and each ampule of diluent are for one use only. (rexhealth.com)
  • Each 1 gram vial contains 1 gram aztreonam with approximately 780 mg arginine. (nih.gov)
  • Each 2 gram vial contains 2 grams aztreonam with approximately 1.56 grams arginine. (nih.gov)
  • The recommended dose of CAYSTON for both adults and pediatric patients 7 years of age and older is one single-use vial (75 mg of aztreonam) reconstituted with 1 mL of sterile diluent administered 3 times a day for a 28-day course (followed by 28 days off CAYSTON therapy). (rxlist.com)
  • A dose of CAYSTON consists of a single-use vial of sterile, lyophilized aztreonam (75 mg) reconstituted with a 1 mL ampule of sterile diluent (0.17% sodium chloride). (rxlist.com)
  • A Veterans Affairs (VA) hospital evaluated use of aztreonam by analyzing NHSN Antimicrobial Use (AU) Option data pulled monthly from NHSN. (cdc.gov)
  • The Pharmacy and Therapeutics (P&T) Antimicrobial Subcommittee determined that use of aztreonam was higher than anticipated. (cdc.gov)
  • As of the 1st Quarter of 2019, the use of aztreonam at the facility has decreased to approximately 10 antimicrobial days per 1000 days present. (cdc.gov)
  • Aztreonam maintains its antimicrobial activity over a pH range of 6 to 8 in vitro, as well as in the presence of human serum and under anaerobic conditions. (drugbank.ca)
  • Aztreonam, a new monobactam antimicrobial. (medchemexpress.com)
  • There were 3 superinfections, 7 relapses and 3 reinfections in the aztreonam group and 1 failure, 1 superinfection, 6 relapses and 5 reinfections in the cefotaxime group. (uni-regensburg.de)
  • Given the extremely high aztreonam concentrations achieved in the lower airways by nebulization, we speculate this may extend its spectrum of activity to other organisms. (biomedcentral.com)
  • In response to high aztreonam use, the facility developed training and educational materials to evaluate the risk of an adverse reaction from beta-lactam administration in a patient whose recorded medical history included a penicillin allergy. (cdc.gov)
  • Aztreonam injection also may be used before, during, and sometimes for a brief period after surgery in order to prevent the patient from getting an infection. (medlineplus.gov)
  • Aztreonam will not treat a viral infection such as the common cold or flu. (rexhealth.com)
  • Aztreonam is usually given as long as needed until your infection has cleared or you have been symptom-free for at least 48 hours. (rexhealth.com)
  • To help clear up your infection completely, aztreonam must be given for the full time of treatment, even if you begin to feel better after a few days. (drugs.com)
  • Aztreonam has also been administered before, during, and occasionally after surgery, in an effort to prevent a post-surgical infection from setting in, if the patient is particularly susceptible to them. (healthery.com)
  • Likewise, aztreonam is often used following colorectal surgery, where it acts to prevent future infection. (healthery.com)
  • In order for your infection to clear up entirely, aztreonam must be taken for the full course of treatment prescribed by your doctor, even if you start feeling better after a couple of days or so. (healthery.com)
  • You must check to make sure that it is safe for you to take aztreonam (oral inhalation) with all of your drugs and health problems. (drugs.com)
  • Tell all of your health care providers that you take aztreonam (oral inhalation). (drugs.com)
  • You will need to talk about the benefits and risks of using aztreonam (oral inhalation) while you are pregnant. (drugs.com)
  • Use aztreonam (oral inhalation) as ordered by your doctor. (drugs.com)
  • Follow how to take aztreonam (oral inhalation) as you have been told by your doctor. (drugs.com)
  • Keep taking aztreonam (oral inhalation) as you have been told by your doctor or other health care provider, even if you feel well. (drugs.com)
  • Do not mix aztreonam (oral inhalation) until you are ready to use it. (drugs.com)
  • Use a puffer (inhaler) that helps open your airways before using aztreonam (oral inhalation). (drugs.com)
  • Use aztreonam (oral inhalation) after other breathed in drugs. (drugs.com)
  • Lung function has gotten worse in some people after taking aztreonam (oral inhalation) for 28 days. (drugs.com)
  • Have your lung function checked while taking aztreonam (oral inhalation). (drugs.com)
  • Call your doctor right away if breathing problems are new or worse after starting aztreonam (oral inhalation). (drugs.com)
  • C. hominis and other HACEK organisms also exhibit in vitro susceptibility to trimethoprim-sulfamethoxazole, fluoroquinolones, and aztreonam. (wikipedia.org)
  • Did the line list include aztreonam, tobramycin, amikacin, gentamicin or zanamivir administered through the respiratory tract? (cdc.gov)
  • Click Aztreonam Injection Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider. (emedtv.com)
  • Like similar compounds, aztreonam inhibits penicillin binding proteins. (thomassci.com)
  • After providing education to the inpatient pharmacists in January 2017, prescribing of aztreonam decreased substantially (Figure). (cdc.gov)
  • Also since January 2017, the facility has used the NHSN AU Option data to look for spikes in aztreonam use and provided re-education to the inpatient pharmacists in July 2018 due to an uptake in use. (cdc.gov)
  • Aztreonam, in contrast, has been shown to be a potent inhibitor of the chromosomal cephalosporinases from Enterobacter cloacae , C. freundii , Serratia spp. (asm.org)