AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, Agriculture
AzoxymethaneColonic NeoplasmsCarcinogensRats, Inbred F344Aberrant Crypt FociColonAzo CompoundsPrecancerous ConditionsDextran SulfateIntestinal NeoplasmsAnticarcinogenic AgentsIntestinal MucosaTabebuiaCocarcinogenesisColitisMethylazoxymethanol AcetateCorn OilMonomethylhydrazinePiroxicamAdenomaDuodenal NeoplasmsCyclooxygenase 2Fish Oilsbeta CateninAdenocarcinomaNucleolus Organizer RegionDimethylhydrazinesCell Transformation, NeoplasticPhytic AcidCarcinogenesisRutinColorectal NeoplasmsOrnithine DecarboxylaseChemopreventionDietUrsodeoxycholic AcidBody Weight1,2-DimethylhydrazineSulindacDisease Models, AnimalNeoplasms, Experimental
Azoxymethane
A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.
Colonic Neoplasms
Tumors or cancer of the COLON.
Carcinogens
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Rats, Inbred F344
Aberrant Crypt Foci
Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.
Colon
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Azo Compounds
Precancerous Conditions
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Dextran Sulfate
Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.
Intestinal Neoplasms
Tumors or cancer of the INTESTINES.
Anticarcinogenic Agents
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
Intestinal Mucosa
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Tabebuia
A plant genus of the family BIGNONIACEAE that is a source of lapachol.
Cocarcinogenesis
The combination of two or more different factors in the production of cancer.
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
Methylazoxymethanol Acetate
The aglycone of CYCASIN. It acts as a potent carcinogen and neurotoxin and inhibits hepatic DNA, RNA, and protein synthesis.
Corn Oil
Oil from ZEA MAYS or corn plant.
Monomethylhydrazine
Hydrazine substituted by one methyl group.
Piroxicam
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
Adenoma
A benign epithelial tumor with a glandular organization.
Duodenal Neoplasms
Tumors or cancer of the DUODENUM.
Cyclooxygenase 2
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
Fish Oils
Oils high in unsaturated fats extracted from the bodies of fish or fish parts, especially the LIVER. Those from the liver are usually high in VITAMIN A. The oils are used as DIETARY SUPPLEMENTS. They are also used in soaps and detergents and as protective coatings.
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.
Nucleolus Organizer Region
The chromosome region which is active in nucleolus formation and which functions in the synthesis of ribosomal RNA.
Dimethylhydrazines
Hydrazines substituted with two methyl groups in any position.
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Phytic Acid
Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.
Carcinogenesis
The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
Rutin
A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Ornithine Decarboxylase
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
Chemoprevention
The use of chemical compounds to prevent the development of a specific disease.
Diet
Regular course of eating and drinking adopted by a person or animal.
Ursodeoxycholic Acid
An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
1,2-Dimethylhydrazine
A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
Sulindac
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Neoplasms, Experimental
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

Effect of meat (beef, chicken, and bacon) on rat colon carcinogenesis. (1/492)

High intake of red meat or processed meat is associated with increased risk of colon cancer. In contrast, consumption of white meat (chicken) is not associated with risk and might even reduce the occurrence of colorectal cancer. We speculated that a diet containing beef or bacon would increase and a diet containing chicken would decrease colon carcinogenesis in rats. One hundred female Fischer 344 rats were given a single injection of azoxymethane (20 mg/kg i.p.), then randomized to 10 different AIN-76-based diets. Five diets were adjusted to 14% fat and 23% protein and five other diets to 28% fat and 40% protein. Fat and protein were supplied by 1) lard and casein, 2) olive oil and casein, 3) beef, 4) chicken with skin, and 5) bacon. Meat diets contained 30% or 60% freeze-dried fried meat. The diets were given ad libitum for 100 days, then colon tumor promotion was assessed by the multiplicity of aberrant crypt foci [number of crypts per aberrant crypt focus (ACF)]. The ACF multiplicity was nearly the same in all groups, except bacon-fed rats, with no effect of fat and protein level or source (p = 0.7 between 8 groups by analysis of variance). In contrast, compared with lard- and casein-fed controls, the ACF multiplicity was reduced by 12% in rats fed a diet with 30% bacon and by 20% in rats fed a diet with 60% bacon (p < 0.001). The water intake was higher in bacon-fed rats than in controls (p < 0.0001). The concentrations of iron and bile acids in fecal water and total fatty acids in feces changed with diet, but there was no correlation between these concentrations and the ACF multiplicity. Thus the hypothesis that colonic iron, bile acids, or total fatty acids can promote colon tumors is not supported by this study. The results suggest that, in rats, beef does not promote the growth of ACF and chicken does not protect against colon carcinogenesis. A bacon-based diet appears to protect against carcinogenesis, perhaps because bacon contains 5% NaCl and increased the rats' water intake.  (+info)

Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. (2/492)

Evidence is accumulating which indicates that cyclooxygenase-2 (COX-2) is involved in the pathogenesis of colorectal cancer. We evaluated the expression of COX-2 in replication error-positive (RER) colon cancers, colon cancers metastatic to liver and azoxymethane (AOM)-induced rat colonic tumors. Immunohistochemistry showed that COX-2 was low to undetectable in normal human mucosa, but abundant in the RER adenocarcinomas we examined. COX-2 immunoreactivity in metastatic colon cancers was less abundant, but clearly detectable. In the colon of AOM-treated rats, COX-2 protein was not detectable in normal mucosa, but present in most of the epithelial cells comprising the tumors. The TGF-beta1 staining pattern in these human and rat tumors was similar to that observed for COX-2. The role of TGF-beta in RER adenocarcinomas is complex because of the increased mutation rate of TGF-beta type II receptors. Northern analysis showed abundant TGF-beta1 mRNA in AOM-induced tumors, but not in paired mucosa. TGF-beta1 induced the expression of COX-2 mRNA and protein in intestinal epithelial cells (IEC-6). Chronic TGF-beta1 treatment caused a TGF-beta-dependent overexpression of COX-2 in rat intestinal epithelial cells (RIE-1). TGF-beta1 may regulate COX-2 expression during the colonic adenoma to carcinoma sequence.  (+info)

Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. (3/492)

We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with 2-(carboxyphenyl)retinamide (2-CPR) prevented aberrant crypt foci (ACF). In this study, we evaluated the effect of 2-CPR on AOM-induced colon tumors and the effect of the three retinoids on apoptosis and cell proliferation. Male F344 rats were administrated 15 mg/kg AOM at weeks 7 and 8 of age. 2-CPR (315 mg/kg) was administered in the diet starting either 1 week before or at week 12 after the first dose of AOM. The rats continued to receive the 2-CPR until killed at week 46. Unlike the demonstrated prevention of colon cancer by the other two retinoids, both dosing schedules of 2-CPR resulted in an approximate doubling of the yield of colon tumors. In adenomas, 2-CPR, 4-HPR and 9-cis-RA were equally effective in reducing mitotic activity, while only 4-HPR and 9-cis-RA but not 2-CPR enhanced apoptosis. When administered for only the 6 days prior to killing 4-HPR but not 2-CPR decreased the Mitotic Index and increased the Apoptotic Index in adenomas. In non-involved crypts, chronic exposure to 4-HPR and 9-cis-RA in contrast to 2-CPR reduced the Mitotic Index and enhanced the Apoptotic Index. In concurrence with our previous study, both 2-CPR and 4-HPR were very potent in preventing ACF when administered in the diet starting 1 week before the first dose of AOM and continuing for the 5 weeks of the study. Hence, unlike the other two retinoids, 2-CPR, although very potent in preventing ACF, enhanced rather than prevented AOM-induced colon cancer. Furthermore, our results suggest that the effect of 2-CPR on tumor yield is different from 4-HPR and 9-cis-RA because, unlike them, it does not enhance apoptosis.  (+info)

Prevention by aspirin and its combination with alpha-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci and prostaglandin E2 levels in rat colon. (4/492)

The dose-response relationship in male F344 rats was determined for the ability of aspirin administered in the diet to prevent azoxymethane (AOM)-induced colon cancer and aberrant crypt foci (ACF) and to reduce prostaglandin E2 (PGE2) levels. Starting at either 7 or 22 weeks of age, the rats received aspirin. All rats received two doses of AOM (15 mg/kg each on days 7 and 14) and were killed on day 36. The lowest concentrations of aspirin to prevent ACF or reduce PGE2 levels were 600 and 400 mg/kg, respectively. To evaluate the prevention of tumors, rats received either 0 or 400 mg/kg aspirin for a total of 39 weeks with AOM (30 mg/kg) administered 7 days after the start of treatment. Aspirin had no effect on the yield of colon tumors. In a second experiment, rats started to receive 0, 200, 600 or 1800 mg/kg aspirin or 1000 mg/kg alpha-difluoromethylornithine (DFMO) +/- aspirin. Eight and 15 days later, all the rats received 15 mg/kg AOM. Eleven weeks later, animals that were receiving the control diet started to receive 0, 200, 600 or 1800 mg/kg aspirin; 1000 or 3000 mg/kg DFMO; or 1000 mg/kg DFMO + 200 or 600 mg/kg aspirin. The animals were killed 32 weeks later. DFMO effectively reduced the yield of colon tumors when administered starting either before or after AOM while aspirin was much weaker. The combination of aspirin + DFMO administered after AOM was synergistic. Both aspirin and DFMO decreased the Mitotic Index, while apoptosis was increased only by DFMO. Our results demonstrated that aspirin and DFMO could prevent colon cancer when administered after AOM. Furthermore, aspirin reduced ACF, PGE2 levels and mitosis at concentrations that did not prevent cancer. In contrast, the ability to enhance apoptosis did correlate with the prevention of cancer.  (+info)

Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor. (5/492)

Inducible nitric oxide synthase (iNOS) is overexpressed in colonic tumors of humans and also in rats treated with a colon carcinogen. iNOS appear to regulate cyclooxygenase-2 (COX-2) expression and production of proinflammatory prostaglandins, which are known to play a key role in colon tumor development. Experiments were designed to study the inhibitory effects of S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT) a selective iNOS-specific inhibitor, measured against formation of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF). Beginning at 5 weeks of age, male F344 rats were fed experimental diets containing 0 or 50 p.p.m. of PBIT, or 2000 p.p.m. of curcumin (non-specific iNOS inhibitor). One week later, rats were injected s.c. with AOM (15 mg/kg body wt, once weekly for 2 weeks). At 17 weeks of age, all rats were killed, colons were evaluated for ACF formation and colonic mucosa was assayed for isoforms of COX and NOS activities. Both COX and iNOS activities in colonic mucosa of the AOM-treated rats were significantly induced. Importantly, 50 p.p.m. PBIT suppressed AOM-induced colonic ACF formation to 58% (P < 0.0001) and crypt multiplicity containing four or more crypts per focus to 78% (P < 0.0001); it also suppressed AOM-induced iNOS activity. Curcumin inhibited colonic ACF formation by 45% (P < 0.001). These observations suggest that iNOS may play a key regulatory role in colon carcinogenesis. Developing iNOS-specific inhibitors may provide a selective and safe chemopreventive strategy for colon cancer treatment.  (+info)

Preliminary analysis of azoxymethane-induced colon tumorigenesis in mouse aggregation chimeras. (6/492)

Inbred mice exhibit differential susceptibility to colon carcinogens. The following study addresses the possibility that differences are intrinsic to colonic mucosa (cell autonomous) or are mediated by extracolonic systemic factors (e.g. liver activation of carcinogens). Our approach was to construct mouse aggregation chimeras, mice whose tissues are a mosaic of cells derived from two parental genotypes, from a susceptible (SWR) and a resistant (DBA/2) strain. Forty-five embryo aggregations yielded 11 viable pups, four of which were chimeric by coat color. Six-week-old SWR<-->BA/2 chimeras were injected i.p. with azoxymethane (AOM) once a week for 8 weeks (5 and 7.5 mg/kg body wt for 2 weeks followed by 10 mg/kg for 6 weeks) and tumor incidence in distal colon was evaluated 15 weeks after the last injection. Additional groups of parental mice received the same treatment. In the parental SWR treatment group, 1.7 +/- 0.82 tumors/colon were found. No tumors were observed in AOM-treated DBA/2 mice. In SWR<-->DBA/2 chimeras exposed to AOM, 2.8 +/- 2.1 tumors/colon were found. Tumor lineage was examined in paraffin sections stained with Dolichos biflorus agglutinin-peroxidase, a cell surface specific marker that stains intestinal endothelial cells of SWR and epithelial cells of DBA/2. Cellular lineage of tumors was further evaluated by microsatellite analysis of DNA isolated by microdissection. There was no significant difference in tumor incidence between SWR parental and chimera treatment groups. Histochemical analysis of tumor tissue in chimeras suggested that most tumors were derived from SWR. However, subsequent genetic analysis of tumors indicated mixed parental composition. These preliminary studies suggest that DBA/2 resistance mechanisms are not sufficient to protect adjacent SWR-derived epithelium from the tumorigenic effects of AOM.  (+info)

Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics. (7/492)

Epidemiological and experimental data suggest that dietary fiber and fat are major determinants of colorectal cancer. However, the mechanisms by which these dietary constituents alter the incidence of colon cancer have not been elucidated. Evidence indicates that dominant gain-of-function mutations short-circuit protooncogenes and contribute to the pathogenesis of cancer. Therefore, we began to dissect the mechanisms whereby dietary fat and fiber, fed during the initiation, promotion and progression stages of colon tumorigenesis, regulate ras p21 localization, expression and mutation frequency. Male Sprague-Dawley rats (140) were provided with corn oil or fish oil and pectin or cellulose plus or minus the carcinogen azoxymethane (AOM) in a 2 x 2 x 2 factorial design and killed after 34 weeks. We have previously shown adenocarcinoma incidence in these animals to be 70.3% (52/74) for corn oil + AOM and 56.1% (37/66) for fish oil + AOM (P < 0.05). Total ras expression as well as ras membrane:cytosol ratio was 4- to 6-fold higher in colon tumors than in mucosa from AOM- or saline-injected rats. Expression of ras in the mucosal membrane fraction was 13% higher for animals fed corn oil compared with fish oil feeding (P < 0.05), which is noteworthy since ras must be localized at the plasma membrane to function. The elevated ras membrane:cytosol ratio in tumors was not due to increased farnesyl protein transferase activity or prenylation state, as nearly all detectable ras was in the prenylated form. Phosphorylated p42 and p44 mitogen activated protein kinase (ERK) expression was two-fold higher in tumor extracts compared with uninvolved mucosa from AOM- and saline-injected rats (P < 0.05). The frequency of K-ras mutations was not significantly different between the various groups, but there was a trend toward a greater incidence of mutations in tumors from corn oil fed rats (85%) compared with fish oil fed rats (58%). Our results indicate that the carcinogen-induced changes in ras expression and membrane localization are associated with the in vivo activation of the ERK pathway. In addition, suppression of tumor development by dietary n-3 polyunsaturated fatty acids may be partly due to a combined effect on colonic ras expression, membrane localization, and mutation frequency.  (+info)

Polyethylene-glycol, a potent suppressor of azoxymethane-induced colonic aberrant crypt foci in rats. (8/492)

Bulking fibers and high water intake may decrease colon carcinogenesis in rats, and the risk of colorectal cancer in humans. We speculated that a non-fermented polymer, polyethylene-glycol (PEG) 8000, which increases stool moisture, might protect rats against colon carcinogenesis. Thirty female F344 rats were given a single injection of azoxymethane (20 mg/kg), and 7 days later randomized to AIN76 diets containing PEG (to provide 3 g/kg body wt/day), or no PEG (control). Diets were given ad libitum for 105 days, then colon carcinogenesis was assessed by the aberrant crypt foci (ACF) test. ACF were scored blindly by a single observer. Dietary feeding of PEG almost suppressed ACF larger than one crypt, and strikingly decreased the total number of ACF per rat. PEG-fed rats had 100 times less large ACF than controls (0.8 and 83 respectively, P = 0.00001). PEG-fed rats had 20 times less total ACF than control (six and 107 ACF/rat, respectively; P < 0.0001). Two treated rats had no detectable ACF. PEG is 10 times more potent than other chemopreventive agents in this model. Since PEG is generally recognized as safe, its cancer-preventive features could be tested in humans.  (+info)

Effect of Restricted Caloric Intake on Azoxymethane-induced Colon Tumor Incidence in Male F344 Rats | Cancer ResearchEffect of Restricted Caloric Intake on Azoxymethane-induced Colon Tumor Incidence in Male F344 Rats | Cancer Research
The effect of 30% caloric restriction on azoxymethane (AOM)-induced colon carcinogenesis was investigated in male F344 rats. Starting at 5 weeks of age, groups of animals were fed ad libitum a high-fat (23.5%) semipurified diet. At 7 weeks of age, all animals except the vehicle-treated groups were s.c. injected with AOM (15 mg/kg body wt, once weekly for 2 weeks). Four days after the second AOM injection, groups of animals were continued on high-fat diet and fed ad libitum (ad libitum group) whereas other groups were restricted to 70% of total calories (calorie-restricted group) consumed by the ad libitum group, but received same amounts of fiber, vitamins, and minerals. Thirty-two weeks after AOM injections, all animals were necropsied. The animals in the calorie-restricted group developed significantly fewer colon tumors and had a lower colon tumor incidence than did the rats in the ad libitum group. The size of colon tumors was also reduced in the calorie-restricted group.. ...
https://cancerres.aacrjournals.org/content/47/5/1226?ijkey=3052540f25862d99ef2fc1061e9855bcf5d928b5&keytype2=tf_ipsecsha
Effect of diets fortified with tomatoes or onions with variable quercetin-glycoside content on azoxymethane-induced aberrant...
TY - JOUR. T1 - Effect of diets fortified with tomatoes or onions with variable quercetin-glycoside content on azoxymethane-induced aberrant crypt foci in the colon of rats. AU - Femia, A.P.. AU - Caderni, G.. AU - Ianni, M.. AU - Salvadori, M.. AU - Schijlen, E.G.W.M.. AU - Collins, G.. AU - Bovy, A.G.. AU - Dolara, P.. PY - 2003. Y1 - 2003. N2 - Background: Onion and tomato are vegetables widely consumed by humans and epidemiological studies show an inverse association between vegetable consumption and colon cancer risk; however, the effect on colon cancer of diets containing high levels of vegetables like onion and tomato are not clear. Aims of the study: To investigate whether tomatoes and onions,with low or high quercetin-glycoside content, could reduce azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF), preneoplastic lesions in the colon of rats. Methods: Male Fisher 344 rats were fed the following diets: a) high fat (HF) diet (control diet); b) HF diet containing 20 % (w/w) tomatoes ...
https://research.wur.nl/en/publications/effect-of-diets-fortified-with-tomatoes-or-onions-with-variable-q
Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition |...Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition |...
Background and aims: The molecular mechanisms underlying the promotion of colorectal carcinogenesis by a high-fat diet (HFD) remain unclear. We investigated the role of the insulin-signal pathway and the c-Jun N-terminal kinase (JNK) pathway, which reportedly play crucial roles in insulin resistance, during colorectal carcinogenesis in the presence of hyperinsulinemia induced by a HFD.. Methods: Azoxymethane-induced aberrant crypt foci formation and cell proliferation in the colonic epithelium were compared between mice fed a normal diet (ND) and mice fed a HFD. A western blot analysis was performed to elucidate the mechanism affecting colorectal carcinogenesis by a HFD.. Results: The number of aberrant crypt foci and the colonic epithelial cell proliferative activity were significantly higher in the HFD group than in the ND group. While the plasma insulin level was significantly higher in the HFD group than in the ND group, a western blot analysis revealed the inactivation of Akt, which is ...
http://gut.bmj.com/content/early/2009/06/30/gut.2009.183624
β-Catenin Is Frequently Mutated and Demonstrates Altered Cellular Location in Azoxymethane-induced Rat Colon Tumors | Cancer...β-Catenin Is Frequently Mutated and Demonstrates Altered Cellular Location in Azoxymethane-induced Rat Colon Tumors | Cancer...
β-Catenin is a key regulator of the cadherin-mediated cell-cell adhesion system and an important element in the Wnt signal transduction pathway. Stabilization and accumulation of cytoplasmic β-catenin, which result from mutations in either the adenomatous polyposis coli or β-catenin genes, are causatively associated with colon carcinogenesis. In the present study, we examined the expression of β-catenin in rat colon tumors induced by azoxymethane in comparison with adjacent normal colon mucosa by immunostaining and immunoblotting. Cytoplasmic and nuclear immunostaining was pronounced in all colon adenoma and carcinoma tissues, whereas antibody binding was limited to membranes at the intercellular borders in normal colon epithelial cells. Increase of the free β-catenin fraction in tumor cells was also indicated by immunoblot analysis of fractionated tissue lysates. Investigation of mutations in the glycogen synthase kinase-3β phosphorylation consensus motif of the β-catenin gene by ...
https://cancerres.aacrjournals.org/content/58/1/42?ijkey=9e94a3463a624c09a815a114390d6d8006118005&keytype2=tf_ipsecsha
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA...
Severe combined immunodeficiency (Scid) mice have defects in V(D)J recombination and DNA double-strand breaks repair caused by an inherited genetic defect in the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs). Scid mice are highly susceptible to development of T-cell lymphomas, and because of the nature of its association with DNA repair and recombination, DNA-PKcs is considered to belong to the caretaker class of tumor suppressor genes. In the present study, the susceptibility of Scid mice to colon carcinogenesis due to administration of azoxymethane (AOM) was investigated. Significantly higher susceptibility in terms of induction of both aberrant crypt foci (ACFs), putative pre-cancerous lesions of the colon and colon cancers was observed as compared with the isogenic strain, C.B-17 mice. The incidences of colon tumors, either adenomas or adenocarcinomas, in Scid and C.B-17 mice after administration of AOM (10 mg/kg body weight/week) for 6 weeks were 87% (26 of 30) and 50% (15 of ...
http://oxfordindex.oup.com/view/10.1093/carcin/22.9.1551
Cell cycle variations in azoxymethane-induced rat colorectal carcinogenesis studied by flow cytometry | IRIS Università degli...Cell cycle variations in azoxymethane-induced rat colorectal carcinogenesis studied by flow cytometry | IRIS Università degli...
Cell cycle variations and DNA aneuploidy, were investigated in different phases of azoxymethane (AOM)-induced colon carcinogenesis in rats by flow cytometry. K-ras gene mutations (transitions Gright curved arrow A) were frequently detected in aberrant crypt foci (ACF) initial pre-neoplastic lesions. The fraction of cells in the G2M-phase of the cell cycle was higher in ACF compared to the normal mucosa of control rats. A similar modification of the cell cycle was found in adenomas and adenocarcinomas but, unexpectedly, also in morphologically normal mucosa from AOM-treated animals indicating that AOM treatment permanently modifies cell cycle control in rat colon mucosa. These alterations, however, were not associated with DNA aneuploidy as reported in human sporadic colorectal cancer, suggesting that tumour development in AOM-treated rats is less dependent on aneuploidy.. ...
https://flore.unifi.it/handle/2158/253284
Plus itPlus it
Purpose: Colon cancer is a major cause of cancer deaths. Dietary factors contribute substantially to the risk of this malignancy. Western-style diets promote development of azoxymethane-induced colon cancer. Although we showed that epidermal growth factor receptors (EGFR) controlled azoxymethane tumorigenesis in standard fat conditions, the role of EGFR in tumor promotion by high dietary fat has not been examined.. Experimental Design: A/J × C57BL6/J mice with wild-type Egfr (Egfrwt) or loss-of-function waved-2 Egfr (Egfrwa2) received azoxymethane followed by standard (5% fat) or western-style (20% fat) diet. As F1 mice were resistant to azoxymethane, we treated mice with azoxymethane followed by one cycle of inflammation-inducing dextran sulfate sodium to induce tumorigenesis. Mice were sacrificed 12 weeks after dextran sulfate sodium. Tumors were graded for histology and assessed for EGFR ligands and proto-oncogenes by immunostaining, Western blotting, and real-time PCR.. Results: Egfrwt mice ...
http://clincancerres.aacrjournals.org/content/early/2009/11/03/1078-0432.CCR-09-1678
Plus itPlus it
Inducible nitric oxide synthase (iNOS) is potential target for inflammation and cancer. Previously, we have shown that S,S′‐1,4‐Phenylenebis(1,2‐ethanediyl)bisisothiourea (PBIT) inhibit colon carcinogenesis induced by azoxymethane (AOM). Although, colon cancer inhibitory efficacy of PBIT has been significant, selective iNOS inhibitors do not completely abrogate NO production due to the exogenous bioavailability and NO generation by eNOS in tumor tissues. To create an iNOS selective and multi‐targeted molecule, we have developed a novel isosteric analogue of PBIT, namely PBISe in which sulfur was replaced with selenium. We examined the chemopreventive efficacy of PBISe on AOM‐induced rat colon carcinogenesis model using aberrant crypt foci (ACF) as end point. At seven weeks of age, rats (12/group) were fed the control diet (AIN 76A) and colonic ACF were induced by AOM. Three days after second AOM treatment, rats were fed the diets containing 0, 10 and 20 ppm of PBI‐Se and continued ...
http://cancerpreventionresearch.aacrjournals.org/content/3/1_Supplement/A35
Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic/knockout progenitors
Azoxymethane (AOM) is a colon carcinogen that is used to study the pathogenesis of sporadic colorectal cancer. We have evaluated differential susceptibility to AOM in inbred mice used as progenitors of recombinant/transgenic lines. In experiment 1, male FVB/N, 129/SvJ, C57Bl/6J mice were treated i.p. with 10 mg/kg AOM once per week for 4 weeks and sacrificed after 20 weeks. Only AOM-treated FVB/N mice developed tumors (3.6 tumors/mouse) in distal colon. In experiment 2, A/J, AKR/J, Balb/CJ mice were treated with AOM for 6 weeks and sacrificed after 24 weeks. AOM-treated A/J and Balb/CJ mice developed 9.2 and 1 tumor/mouse, respectively. Despite these differences, tumors had similar morphology regardless of strain. Immunohistochemistry with β-catenin resulted in marked nuclear and cytoplasmic staining of tumor cells in FVB/N. However, fainter and heterogeneous β-catenin staining was observed in A/J tumors, suggesting distinct pathways of tumorigenesis in different strains. Irrespective of ...
https://tessera.spandidos-publications.com/10.3892/ijo.22.1.145/abstract
A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise | GutA novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise | Gut
Results A single bout of exercise increased the expression and secretion of SPARC in skeletal muscle in both mice and humans. In addition, in an azoxymethane-induced colon cancer mouse model, regular low-intensity exercise significantly reduced the formation of aberrant crypt foci in wild-type mice but not in SPARC-null mice. Furthermore, regular exercise enhanced apoptosis in colon mucosal cells and increased the cleaved forms of caspase-3 and caspase-8 in wild-type mice but not in SPARC-null mice. Culture experiments showed that SPARC secretion from myocytes was induced by cyclic stretch and inhibited proliferation with apoptotic effect of colon cancer cells.. ...
http://gut.bmj.com/content/early/2012/11/15/gutjnl-2011-300776
IJMS | Free Full-Text | Increased Preventive Effect on Colon Carcinogenesis by Use of Resistant Starch (RS3) as the Carrier...IJMS | Free Full-Text | Increased Preventive Effect on Colon Carcinogenesis by Use of Resistant Starch (RS3) as the Carrier...
The preventive effect of polysaccharide of Larimichthys crocea swimming bladder (PLCSB) and the increase of this effect by use of resistant starch (RS3) as the carrier for PLCSB on azoxymethane (AOM) and dextran sulfate sodium (DSS)-inducing colon carcinogenesis in C57BL/6 mice has been studied. RS3 microspheres carrying PLCSB (RS3 + PLCSB) were produced and evaluated as a potentially improved colon carcinogenesis therapy for this study. The body weight, colon length, and colon weight of mice were determined, and colonic tissues were histologically observed. The serum levels of proinflammatory cytokines and the inflammation and apoptosis-related genes in colonic tissue were also tested. The PLCSB or RS3 + PLCSB significantly suppressed AOM and DSS-induced body weight loss, colon length shortening and decreased the colon weight to length ratio. PLCSB or RS3 + PLCSB reduced the levels of the serum pro-inflammatory cytokines IL-6, IL-12, TNF-α, and IFN-γ to a greater extent compared with the control
http://www.mdpi.com/1422-0067/15/1/817/xml
An Assessment of Pyridoxine as a Biological Response Modifier During Colon CarcinogenesisAn Assessment of Pyridoxine as a Biological Response Modifier During Colon Carcinogenesis
The main objective of this proposal was to investigate the effect of vitamin B6 on colon carcinogenesis in vivo. Two in vivo studies were conducted to determine the role of vitamin B6 as a biological modifier of colon carcinogenesis. It is hypothesized that vitamin B6 may serve as an antioxidant in vivo and will modulate colon carcinogenesis. In the first study, a 2X3 factorial experimental design was used to determine if three different levels of vitamin B6, classified as low, normal and high in conjunction with two different levels of protein intake, classified as normal or high, will affect post-initiation stages of colon carcinogenesis, in Sprague-Dawley rats. Male Sprague-Dawley male were injected with azoxymethane for two weeks (15mg/kg/week) and then one week later they were allocated to different dietary treatment groups. After eight weeks, the effects of dietary treatment on hematological status, oxidative stress markers and antioxidant enzymes, as well as enumeration of preneoplastic ...
https://uwspace.uwaterloo.ca/handle/10012/3398
Plus itPlus it
Previous work suggests that vagus nerve disruption reduces hepatocyte and oval cell expansion following liver injury. The role of post-neuronal receptor activation in response to liver injury has not been ascertained. We investigated the actions of scopolamine, a non-selective muscarinic receptor antagonist, and specific genetic ablation of a key cholinergic receptor, muscarinic subtype-3 (Chrm3), on azoxymethane (AOM)-induced liver injury in mice. Animal weights and survival were measured as was liver injury using both gross and microscopic examination. To assess hepatocyte proliferation and apoptosis, ductular hyperplasia and oval cell expansion, we used morphometric analysis of BrdU-, activated caspase-3-, H&E-, CK-19- and EpCAM-stained liver sections. Sirius red staining was used as a measure of collagen deposition and its association with oval cell reaction. In AOM-treated mice, both muscarinic receptor blockade with scopolamine and Chrm3 ablation attenuated hepatocyte proliferation and ...
http://jpet.aspetjournals.org/content/early/2010/03/02/jpet.109.165118
Healthy Weight Week - Healthcanal.com : Healthcanal.comHealthy Weight Week - Healthcanal.com : Healthcanal.com
As the Dietitians Association of Australia (DAA) kicks off Australias Healthy Weight Week today, new research shows that cooking at home more often means Australians will up their fruit and vegetable intake, helping win the war on weight.. The research, involving more than 1,300 people, found those who spent the most time preparing and cooking meals ate more fruit and vegetables and spent less money on food away from home, compared with those who spent the least amount of time in the kitchen.. Given more than nine in 10 Australians dont eat the recommended five serves of vegetables a day, and 63 per cent of adults are overweight or obese, and that number is rising, this is important research, Dietitians Association of Australia (DAA) spokesperson and Co-Director of the Priority Research Centre in Physical Activity and Nutrition at the University of Newcastle, Professor Clare Collins said.. Professor Collins said the quality of a persons diet was a good way of predicting weight; and ...
https://www.healthcanal.com/life-style-fitness/60266-healthy-weight-week.html
Healthy Weight Week!Healthy Weight Week!
Healthy Weight Week signifies the importance of balance diet and healthy lifestyle. Being healthy does not mean losing weight and going on a diet. It means pursuing livable and sustainable healthy lifestyle through eating well, living actively and feeling good. Bentham Science publishes important research publications that promote this idea. Click here to find related…
https://benthamsciencepublishers.wordpress.com/2017/01/19/healthy-weight-week/
IJMS | Free Full-Text | The Dual Role of Inflammation in Colon CarcinogenesisIJMS | Free Full-Text | The Dual Role of Inflammation in Colon Carcinogenesis
Chronic inflammation characterizing patients with inflammatory bowel disease (IBD) represents a major risk factor for the development of colorectal cancer. Mechanisms underlying this neoplastic transformation are not fully understood though studies in experimental models of colon carcinogenesis suggest that inflammatory cell-derived cytokines either directly or indirectly stimulate the uncontrolled growth of cancer cells. Nevertheless, under specific inflammatory conditions, immune cells can boost an anti-tumor immune response with the down-stream effect of eliminating dysplastic and cancerous cells. This review outlines the beneficial and detrimental role of inflammation in colon carcinogenesis.
http://www.mdpi.com/1422-0067/13/9/11071
ACFS | รายการทดสอบACFS | รายการทดสอบ
สำนักงานมาตรฐานสินค้าเกษตรและอาหารแห่งชาติ © 2012 ภาษาไทย ...
http://cssa.acfs.go.th/ImportRequirements.mvc/Details?ReqID=1116&CountryID=139&TradeItemID=158&Grid-orderBy=DocumentsACFS3.DocLabel255-asc
Mustard seeds (Sinapis Alba Linn) attenuate azoxymethane-induced colon carcinogenesisMustard seeds (Sinapis Alba Linn) attenuate azoxymethane-induced colon carcinogenesis
Mustard seeds (MS), which are consumed in considerable amounts by the Japanese people that, interestingly, have the longest life expectancy in the world, are known to contain a number of yet not fully defined but quite powerful anti-oxidants. A suspension of extracted MS was found to suppress oxidized-LDL-induced macrophage respiratory burst in vitro, to prevent growth, and to induce apoptotic death of SW480 cells (a human colon cancer cell line), while no such effects were found for normal 3T3 cells. A diet enriched with MS decreased plasma levels of the lipid peroxidation product malonaldehyde in mice exposed to the colon cancer-inducer azoxymethane (AOM). Such a diet also dose-dependently enhanced the activity of several anti-oxidant enzymes, such as superoxide dismutase (SOD), catalase, and GSH-peroxidase and, moreover, reduced AOM-mediated formation of colon adenomas by about 50%. Further studies are required to detail and explore the beneficial effects of MS and their rich content of ...
http://liu.diva-portal.org/smash/record.jsf?pid=diva2:419714
Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon.* - Propolis Science
Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon.. Shimizu K, Das SK, Baba M, Matsuura Y, Kanazawa K.. Source. Department of Life Science, Graduate School of Science and Technology, Kobe University, Rokkodai, Nada-ku, Kobe 657-8501, Japan.. Abstract. Artepillin C, a prenylated phenylpropanoid found specifically in Brazilian propolis, has been shown to be a bioavailable antioxidant. In this study, artepillin C was tested for colon cancer-preventing activity using azoxymethane-challenged ddY mice. Oral doses of 80 and 160 mg/kg body weight of propolis or 10mg/kg of artepillin C (equi-amounts to 160 mg propolis) reduced significantly the frequency of colonic aberrant crypt foci (ACF) by 39.2, 43.7 and 43.4%, respectively. In liver of the mice, glutathione S-transferase and NADPH:quinone reductase activity increased with the doses of propolis or artepillin C, and an antioxidant-responsive element (ARE) was found to be activated for binding ...
http://www.propolisscience.org/propolis-compounds/artepillin-c-research/dietary-artepillin-c-suppresses-the-formation-of-aberrant-crypt-foci-induced-by-azoxymethane-in-mouse-colon/
Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in...Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in...
The influence of bovine lactoferrin (bLf) on colon carcinogenesis was investigated in male F344 rats treated with azoxymethane (AOM). In experiment I, 2% and 0.2% bLf, and Bifidobacterium longum (B. longum) as a positive control at 3% were given in the diet for 4 weeks, along with two s.c. 15 mg/kg …
https://pubmed.ncbi.nlm.nih.gov/9781370/?dopt=Abstract
Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane...Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane...
Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, individually and in combination, were tested on azoxymethane induced colon carcinogenesis in Sprague-Dawley rats. The effect was observed on aberrant crypt foci (ACF), the preneoplastic lesion. To investigate the mechanism of action of the agents used, cell proliferation and the level of apoptosis were determined and the expression of cyclooxygenase-2 (COX-2) protein was analyzed in the colon. Following treatment, significant inhibition of the level of cell proliferation (P|0.01 in garlic; P|0.001 in tomato and P|0.001 in combination treatment group with respect to the carcinogen control group), significant induction of apoptosis (P|0.01 in garlic treated; P|0.01 in tomato treated and P|0
https://www.semanticscholar.org/paper/Modulatory-influence-of-garlic-and-tomato-on-cyclo-Sengupta-Ghosh/b708749d3be9285f2b83ae2951232a23e6f83e78
Prevention by aspirin and its combination with α-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci...
The dose-response relationship in male F344 rats was determined for the ability of aspirin administered in the diet to prevent azoxymethane (AOM)-induced colon cancer and aberrant crypt foci (ACF) and to reduce prostaglandin E2 (PGE2) levels. Starting at either 7 or 22 weeks of age, the rats received aspirin. All rats received two doses of AOM (15 mg/kg each on days 7 and 14) and were killed on day 36. The lowest concentrations of aspirin to prevent ACF or reduce PGE2 levels were 600 and 400 mg/kg, respectively. To evaluate the prevention of tumors, rats received either 0 or 400 mg/kg aspirin for a total of 39 weeks with AOM (30 mg/kg) administered 7 days after the start of treatment. Aspirin had no effect on the yield of colon tumors. In a second experiment, rats started to receive 0, 200, 600 or 1800 mg/kg aspirin or 1000 mg/kg α-difluoromethylornithine (DFMO) +/- aspirin. Eight and 15 days later, all the rats received 15 mg/kg AOM. Eleven weeks later, animals that were receiving the control ...
http://oxfordindex.oup.com/view/10.1093/carcin/20.3.425
Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands | BMC Cancer | Full TextSuppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands | BMC Cancer | Full Text
It is generally assumed that inflammatory bowel disease (IBD)-related carcinogenesis occurs as a result of chronic inflammation. We previously developed a novel colitis-related mouse colon carcinogenesis model initiated with azoxymethane (AOM) and followed by dextran sodium sulfate (DSS). In the present study we investigated whether a cyclooxygenase (COX)-2 inhibitor nimesulide and ligands for peroxisome proliferator-activated receptors (PPARs), troglitazone (a PPARγ ligand) and bezafibrate (a PPARα ligand) inhibit colitis-related colon carcinogenesis using our model to evaluate the efficacy of these drugs in prevention of IBD-related colon carcinogenesis. Female CD-1 (ICR) mice were given a single intraperitoneal administration of AOM (10 mg/kg body weight) and followed by one-week oral exposure of 2% (w/v) DSS in drinking water, and then maintained on the basal diets mixed with or without nimesulide (0.04%, w/w), troglitazone (0.05%, w/w), and bezafibrate (0.05%, w/w) for 14 weeks. The inhibitory
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-5-46/figures/2
About the Cover | Cancer Prevention ResearchAbout the Cover | Cancer Prevention Research
Aspirin, naproxen, and other nonsteroidal anti-inflammatory drugs (NSAIDs) are promising chemopreventive agents for individuals at high risk for colorectal cancer (CRC). However, uptake of chronic and continuous NSAID administration to reduce CRC risk is limited by unwanted side effects. Employing novel dosing regimens and an azoxymethane-induced rat colon cancer model, Mohammed and colleagues found that intermittent use of either aspirin or naproxen was highly effective in preventing the progression of colonic adenoma to adenocarcinoma without serious side effects (see the study beginning on page 751). These findings could ultimately impact the standard of preventive care for patients at the adenoma stage (i.e., in high-risk cohorts) to protect against advancement to invasive adenocarcinoma with intermittent NSAID use. The micrograph on the cover depicts hematoxylin and eosin staining of rat colon crypt, hyperplasia, adenoma, and adenocarcinomas that recapitulate the histological progression of ...
https://cancerpreventionresearch.aacrjournals.org/content/12/11.cover-expansion
Chemopreventive effects of dietary canola oil on colon cancer development - Dieting Blog
It is pertinent however to determine wholesome cooking strategies in addition to consuming habits in methods to not intervene with the nutritious worth of meals Mother Nature intended. Have you ever ever gone through a grueling weight reduction program for a very long time, solely to seek out out later that youve hit a wall when it comes to outcomes. You wont end up tempted almost as much if your forbidden foods arent simply accessible. Correctly, chances are youll need to do additional than merely discovering a meals plan reply program. He did it greater than 50 years earlier. One factor to remember when deciding how one can go about shedding pounds is that there is no such thing as a single greatest way to lose weight. This can be a weight loss program thats loaded with numerous greens and fruits, chemopreventive effects of dietary canola oil on colon cancer development with the lean meats and likewise other protein sources. Due to this actuality, it is best to avoid excessive consumption ...
http://partykleider.info/dietary/chemopreventive-effects-of-dietary-canola-oil-on-colon-cancer-development.html
Characterization of p53 tumor suppressor pathway in mouse colon epithe by Wataru AizuCharacterization of p53 tumor suppressor pathway in mouse colon epithe by Wataru Aizu
The goal of this study was to characterize p53 tumor suppressor pathway in colon-specific carcinogen azoxymethane (AOM)-induced mouse colon tumor and to assess the usefulness of this animal model to evaluate novel anti-cancer drugs. The acute exposure of mice to AOM showed no overall induction of p53-regulated genes. Subdued p53 gene activation in the colon corresponded to a drop in the expression of its transcriptional co-activator, p300. The status of p53 pathway was further analyzed using AOM-induced mouse colon tumor and the cell line (AJ02-NM0) generated from the primary tumor. Wild type p53 protein, constitutively expressed in this model, showed no detectable DNA binding activity nor did it activate p21 expression. The cell line studies revealed that p53 activity was inhibited by a constitutive interaction with Mdm2. The p53-activating p19/ARF protein did not appear to have significant effect on the standing of p53 pathway in this cell line. p53 was activated by Doxorubicin, 5-FU and the recently
http://opencommons.uconn.edu/dissertations/AAI3239549/
Colon cancer a disease of hormone deficiencyColon cancer a disease of hormone deficiency
But early in colon cancer development, these growth-controlling hormones are lost and not expressed, disrupting GCCs activity, and, Dr. Waldman believes, contributing to tumor formation. Using two separate mouse models that mimic the development of colon cancer in people, his team showed that GCC signaling blocks such tumors from forming. According to Dr. Waldman, the group found that GCC stops tumors from forming through two different mechanisms. In one case, it controls cell growth, while in the other, it maintains regulation of genomic integrity.. In one mouse cancer model, the animals carried mutations in the APC gene, which causes colon polyps that frequently lead to colon cancer. Mice in the other cancer-development model were exposed to a commonly used experimental cancer-causing agent, azoxymethane. We modeled both ways that humans develop colon cancer, and studied the effects of a lack of GCC on the incidence of colon cancer development, he explains.. We found that in animals ...
http://www.innovations-report.com/html/reports/medicine-health/report-88292.html
Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and...Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and...
Background: The group IIA secretory phospholipase A2 gene, Pla2g2a, confers resistance to intestinal tumorigenesis in the ApcMin/+ mouse model. However, it is unclear how Pla2g2a exerts its tumor-suppressive effects and whether its mode of action dep
https://content.iospress.com/articles/analytical-cellular-pathology/clo480
MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. | Hiebert LaboratoryMTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. | Hiebert Laboratory
Myeloid Translocation Gene, Related-1 (MTGR1) CBFA2T2 is a member of the Myeloid Translocation Gene (MTG) family of transcriptional corepressors. The remaining two family members, MTG8 (RUNX1T1) and MTG16 (CBFA2T3) are identified as targets of chromosomal translocations in acute myeloid leukemia (AML). Mtgr1(-/-) mice have defects in intestinal lineage allocation and wound healing. Moreover, these mice show signs of impaired intestinal stem cell function. Based on these phenotypes, we hypothesized that MTGR1 may influence tumorigenesis arising in an inflammatory background. We report that Mtgr1(-/-) mice were protected from tumorigenesis when injected with azoxymethane (AOM) and then subjected to repeated cycles of dextran sodium sulfate (DSS). Tumor cell proliferation was comparable, but Mtgr1(-/-) tumors had significantly higher apoptosis rates. These phenotypes were dependent on epithelial injury, the resultant inflammation, or a combination of both as there was no difference in aberrant ...
https://medschool.vanderbilt.edu/hiebert-lab/publication/mtgr1-required-tumorigenesis-murine-aomdss-colitis-associated-carcinoma-model
Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals : Food Therapy: Dried Peas and...
Interestingly, in the investigated effect of consumption of standard diets supplemented with freeze-dried vegetables (peas, spinach, sprouts and broccoli) and carotenoids (all-trans beta-carotene and palm oil carotenoid extract) on surrogate end-point markers for colorectal cancer in an azoxymethane-induced rat model, researchers at the Unilever Research Vlaardingen, illustrated ...
https://kylejnorton.blogspot.com/2017/10/food-therapy-dried-peas-and-beans-in.html
CiNii 論文 - Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced...
Tanaka Takuji , Sugie Shigeyuki Journal of toxicologic pathology 20(4), 215-235, 2007-12-25 J-STAGE 医中誌Web 参考文献192件 ...
http://ci.nii.ac.jp/naid/10008080567
Study Challenges Previously Held Beliefs About the Role of Genetic Mutations in Colon Cancer DevelopmentStudy Challenges Previously Held Beliefs About the Role of Genetic Mutations in Colon Cancer Development
Bielas and colleagues first set out to analyze mutation rates in mitochondrial DNA because they wanted to see if it could act as a surrogate for nuclear DNA as a cancer biomarker. Cells contain a thousandfold more mitochondrial genetic material than nuclear DNA, so theoretically youd need a thousand times less tissue to get the same genetic information to predict clinical outcomes such as how fast a tumor would progress or whether it would be resistant to therapy, Bielas said.. While mitochondrial DNA proved to be an unreliable stand-in for nuclear DNA as a cancer biomarker, it offers promise as a new drug target.. If we could increase DNA damage and mutation within the mitochondrial genome, theoretically we could decrease cancer, Bielas said. Thats what were testing now. This is a whole new hypothesis.. The way mitochondria maintain genetic stability in the face of cancer, Bielas suggests, may be because unlike normal cells, cancer cells do not need oxygen to survive. In fact, cancer ...
http://www.innovations-report.com/html/reports/life-sciences/study-challenges-previously-held-beliefs-role-196922.html
Experimental carcinogenesis in pregnant mice, a preliminary report. by A Sedlis and D F. StoneExperimental carcinogenesis in pregnant mice, a preliminary report. by A Sedlis and D F. Stone
Sedlis, A and Stone, D F., Experimental carcinogenesis in pregnant mice, a preliminary report. (1965). Subject Strain Bibliography 1965. 820 ...
https://mouseion.jax.org/ssbb1965/820/
Find Your Zone During Healthy Weight Week - Thunderbird Endoscopy Center
Stanford University School of Medicine found that 63 percent of participants in a study who had a positive body image were more successful at losing and maintaining weight for a year compared to a 26 percent success rate for those who were dissatisfied with their appearance (Source: Shape). How can you work toward develop a positive body image? By realizing that fitness is not a number; it is a way of life. Avoid choosing a perfect weight for yourself. Instead, think of your ideal weight as a zone, or a range of weight in which you feel comfortable and beautiful. If you focus on healthy lifestyle instead of a number or a measurement, you can feel truly satisfied ...
https://tbirdendo.com/news-article/find-your-zone-during-healthy-weight-week-01102018
Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability |...Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability |...
The characteristic features of cancer cells are aberrant (acidic) intracellular pH and elevated levels of phosphatidylserine. The primary focus of cancer research is concentrated on the discovery of biomarkers directed towards early diagnosis and therapy. It has been observed that azoxymethane-treated mice demonstrate an increased expression of calnuc (a multi-domain, Ca2+- and DNA-binding protein) in their colon, suggesting it to be a good biomarker of carcinogenesis. We show that culture supernatants from tumor cells have significantly higher amounts of secreted calnuc compared to non-tumor cells, selectively packaged into exosomes. Exosomal calnuc is causal for epithelial-mesenchymal transition and atypical migration in non-tumor cells, which are key events in tumorigenesis and metastasis. In vitro studies reveal a significant affinity for calnuc towards phosphatidylserine, specifically to its C-terminal region, leading to the formation of molten globule conformation. Similar structural ...
https://portlandpress.com/biochemj/article-abstract/478/12/2265/228835/Aberrant-environment-and-PS-binding-to-calnuc-C?redirectedFrom=fulltext
Dr. Mathew Meeneghan on Colon Cancer | Texas OncologyDr. Mathew Meeneghan on Colon Cancer | Texas Oncology
Dr. Mathew Meeneghan joins Debbie Bosque at KULM-FM 98.3 to discuss colon cancer on The Doctors Point of View radio show. Dr. Meeneghan talks about colon cancer development, treatment and screening procedures like colonoscopies.
https://www.texasoncology.com/who-we-are/media-center/media-coverage/radio-coverages/2017/a-doctors-point-of-view-dr-mathew-meeneghan-on?feed=TexasOncology
Gut microbes provide link between carbs and colon cancer - ONAGut microbes provide link between carbs and colon cancer - ONA
Physicians have long suspected a link between carbohydrate intake and colon cancer development, and a recent study may have illuminated the sought-after link.
http://www.oncologynurseadvisor.com/headlines/gut-microbes-provide-link-between-carbs-and-colon-cancer/article/362314/
Why you MUST eat healthy this week - Capital LifestyleWhy you MUST eat healthy this week - Capital Lifestyle
If you havent been eating healthy since the week began you must try to catch up. Why? Because its Healthy Weight Week (HWW), is why. The annual HWW is A Kenyan lifestyle platform for digital storytelling.
https://www.capitalfm.co.ke/lifestyle/2012/01/18/why-you-must-eat-healthy-this-week/
alpha-Eleostearic acid - Wikipediaalpha-Eleostearic acid - Wikipedia
In their pioneering work on essential fatty acids, Burr, Burr and Miller compared the nutritional properties of α-eleostearic acid (ELA) to that of its isomer alpha-linolenic acid (ALA). ALA relieved essential fatty acid deficiency; ELA did not.[1] In rats, α-eleostearic acid is converted to a conjugated linoleic acid.[2] The compound has been found to induce programmed cell death of fat cells,[3] and of HL60 leukemia cells in vitro at a concentration of 20 μM.[4] Diets containing 0.01% bitter gourd seed oil (0.006% as α-eleostearic acid) were found to prevent azoxymethane-induced colon carcinogenesis in rats.[5] ...
https://en.wikipedia.org/wiki/Alpha-Eleostearic_acid
The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded...The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded...
The incidence and mortality rates of colorectal cancer (CRC) continue to increase worldwide. Therefore, new preventive strategies are needed to lower the burden of this disease. Previous studies reported that aspirin could suppress the development of sporadic colorectal adenoma. In addition, metformin is a biguanide derivative that is long widely used for the treatment of diabetes mellitus and has recently been suggested to have a suppressive effect on carcinogenesis and cancer cell growth. Both drugs exhibit a chemopreventive effect, but their efficacy is limited. Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger in diameter and stain more darkly with methylene blue than normal crypts, are more prevalent in patients with cancer and adenomas, and considered a reliable surrogate biomarker of CRC. Thus, we designed a prospective trial as a preliminary study prior to a CRC chemoprevention trial to evaluate the chemopreventive effect of aspirin combined with metformin on
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-07564-z
Folic Acid Supplementation and Prevention of Colitis-Associated Colorectal Cancer - Margie ClapperFolic Acid Supplementation and Prevention of Colitis-Associated Colorectal Cancer - Margie Clapper
Routine fortification of food with folic acid was implemented in the U.S. in 1996 to reduce the risk of birth defects in newborns. Widespread fortification in c...
http://grantome.com/grant/NIH/R21-CA176345-01A1
The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. - Semantic ScholarThe cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. - Semantic Scholar
US28 is a constitutively active chemokine receptor encoded by CMV (also referred to as human herpesvirus 5), a highly prevalent human virus that infects a broad spectrum of cells, including intestinal epithelial cells (IECs). To study the role of US28 in vivo, we created transgenic mice (VS28 mice) in which US28 expression was targeted to IECs. Expression of US28 was detected in all IECs of the small and large intestine, including in cells expressing leucine rich repeat containing GPCR5 (Lgr5), a marker gene of intestinal epithelial stem cells. US28 expression in IECs inhibited glycogen synthase 3β (GSK-3β) function, promoted accumulation of β-catenin protein, and increased expression of Wnt target genes involved in the control of the cell proliferation. VS28 mice showed a hyperplastic intestinal epithelium and, strikingly, developed adenomas and adenocarcinomas by 40 weeks of age. When exposed to an inflammation-driven tumor model (azoxymethane/dextran sodium sulfate), VS28 mice developed a
https://www.semanticscholar.org/paper/The-cytomegalovirus-encoded-chemokine-receptor-US2-Bongers-Maussang/1c369e086b68526bfa5f76a4828c2af2b999e4f8
Most recent papers with the keyword Microadenoma | Read by QxMDMost recent papers with the keyword Microadenoma | Read by QxMD
Natural killer (NK) cells are an essential component of innate immunity against cancer development. Many studies have been conducted to evaluate immune-modulating effects using dietary compounds. Our laboratory has been investigating the chemopreventive potential of black raspberries (BRBs) and previously demonstrated their beneficial modulation of genetic and epigenetic biomarkers in patients with colorectal cancer (CRC). The current study investigated their potential on modulating NK cells. To avoid the excessive inflammation caused by the dextran sulfate sodium (DSS) treatment that leads to colitis, we treated the mice with overnight DSS so that it would slightly irritate the colon but still promote colon carcinogenesis with 100% incidence in both the Apc(Min/+) mice and azoxymethane (AOM)-treated mice ...
https://www.readbyqxmd.com/keyword/63818
JCI Insight - WelcomeJCI Insight - Welcome
Cardiac fibrosis is a pathophysiologic hallmark of the aging heart. In the uninjured heart, cardiac fibroblasts exist in the quiescent state, but little is known about how proliferation rates and fibroblast transcriptional programs change throughout the lifespan of the organism from the immediate postnatal period to adult life and old age. Using EdU pulse labeling, we demonstrate that more than 50% of cardiac fibroblasts are actively proliferating in the first day of post-natal life. However, within 4 weeks of birth in the juvenile animal, only 10% of cardiac fibroblasts are proliferating. By early adulthood, the fraction of proliferating cardiac fibroblasts further decreases to approximately 2%, where it so remains throughout the rest of the organisms life span. Examination of absolute cardiac fibroblast numbers demonstrated concordance with age related changes in fibroblast proliferation with no significant differences in absolute cardiac fibroblast numbers between animals 14 weeks and 1.5 ...
https://insight.jci.org/tags/61
Not Even a Bag of Sugar: Weight Week - A Wake Up Call
Everyone needs a wakeup call Kylie. I got mine when I went to my doctor, and my cholesterol was very high. She said loose weight, or go on medication. I hate medication, and so have started seeing a dietician and have currently lost around 10 kilos. I actually lost all my weight years ago, after having Michael, but then put it all back on again after he got his diagnosis! Have discovered I am a stress eater, and it is very hard not to eat when stressed, but I am getting better! Good luck Kylie, it is not an easy battle! xx. ReplyDelete ...
http://www.notevenabagofsugar.co.uk/2011/11/weight-week-wake-up-call.html?showComment=1321975577954
2 immune-system proteins linked to colitis-associated cancer2 immune-system proteins linked to colitis-associated cancer
Recent research from the laboratory of Michael Karin, PhD, at the University of California, San Diego School of Medicine - the first researcher to demonstrate a molecular link between inflammation and cancer - has identified ...
https://medicalxpress.com/news/2009-02-immune-system-proteins-linked-colitis-associated-cancer.html
Pterostilbene.com - Independent information about Pterostilbene
Pterostilbene : The official website. Everything to know about Pterostilbene : Health benefits ? Dosage ? Where to order the best quality ? And more...
http://www.pterostilbene.com
ASPPH | ASPPH Members Highlight Obesity InitiativesASPPH | ASPPH Members Highlight Obesity Initiatives
In observance of Healthy Weight Week January 16-20, we asked our members what they are currently doing in regards to the overwhelming levels of obesity around us. View the links below to see what our members are doing.. ...
https://www.aspph.org/aspph-members-highlight-obesity-initiatives-3/
Weight gain | BabyCentreWeight gain | BabyCentre
Hi mamas I was wondering if anyone knew much about weight gain in pregnancy. Ive lost 2lbs since my booking weight but am consistently staying at the same weight week after week now. Im nearly 16 weeks. Im not too worried but just curious if its ok that Im not gaining…
https://community.babycentre.co.uk/post/a32961268/weight-gain
Pterostilbene: A Potent Activator of NRF2
Pterostilbene has many healthful properties that you discover article after article through your site pterostilbene.com. Some of its healthful properties
http://www.pterostilbene.com/potent-activator-of-nrf2/
AzoxymethaneAzoxymethane
... at Sigma-Aldrich CID 33184 from PubChem (PubChem ID (CID) same as Wikidata, Articles without EBI source, Articles ... Azoxymethane (AOM) is a carcinogenic and neurotoxic chemical compound used in biological research. It is the oxide of ...
https://en.wikipedia.org/wiki/Azoxymethane
JugloneJuglone
"Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats". Cancer Lett. 127 (1-2 ...
https://en.wikipedia.org/wiki/Juglone
Prostaglandin EP1 receptorProstaglandin EP1 receptor
It promotes colon cancer development in Azoxymethane-induced and APC gene knockout mice. 3) It promotes hypertension in ...
https://en.wikipedia.org/wiki/Prostaglandin_EP1_receptor
FuranolactoneFuranolactone
"A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis". Cancer ...
https://en.wikipedia.org/wiki/Furanolactone
Mouse model of colorectal and intestinal cancerMouse model of colorectal and intestinal cancer
Azoxymethane (AOM) is a genotoxic colonic carcinogen and is routinely used to induce colon tumours in mice. The AOM-induced ... Treatment of this mouse model with the procarcinogen azoxymethane (AOM) leads to formation of dysplastic microadenomas in the ... "A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate". Cancer Sci. ...
https://en.wikipedia.org/wiki/Mouse_model_of_colorectal_and_intestinal_cancer
Azoxy compoundsAzoxy compounds
... azoxymethane are suspected to be genotoxic. IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online ...
https://en.wikipedia.org/wiki/Azoxy_compounds
Rice vinegarRice vinegar
Inhibits Azoxymethane-Induced Colon Carcinogenesis in Male F344 Rats". Nutrition and Cancer. 49 (2): 170-3. doi:10.1207/ ...
https://en.wikipedia.org/wiki/Rice_vinegar
HPG80HPG80
... a significant increase in tumor formation was observed in mice overexpressing progastrin and treated with azoxymethane (AOM), a ... expression of mutant and wild-type progastrin significantly increases colon carcinogenesis in response to azoxymethane in ...
https://en.wikipedia.org/wiki/HPG80
HederaHedera
Falcarinol on Development of Azoxymethane-Induced Preneoplastic Lesions in the Rat Colon". Journal of Agricultural and Food ...
https://en.wikipedia.org/wiki/Hedera
Escherichia coli NC101Escherichia coli NC101
... in while performing experiments in azoxymethane treated mice. The findings of the study found "...tumorigenesis by altering ...
https://en.wikipedia.org/wiki/Escherichia_coli_NC101
Peucedanum japonicumPeucedanum japonicum
... on azoxymethane-induced colon preneoplastic lesions in male F344 rats". Cancer Letters. 205 (2): 133-141. doi:10.1016/j.canlet. ...
https://en.wikipedia.org/wiki/Peucedanum_japonicum
Alpha-Eleostearic acidAlpha-Eleostearic acid
Diets containing 0.01% bitter gourd seed oil (0.006% as α-eleostearic acid) were found to prevent azoxymethane-induced colon ... "Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis ...
https://en.wikipedia.org/wiki/Alpha-Eleostearic_acid
O-6-methylguanine-DNA methyltransferaseO-6-methylguanine-DNA methyltransferase
However, stressful treatment of mice with azoxymethane and dextran sulphate caused more than four colonic tumors per MGMT ...
https://en.wikipedia.org/wiki/O-6-methylguanine-DNA_methyltransferase
List of vegetable oilsList of vegetable oils
"Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis ...
https://en.wikipedia.org/wiki/List_of_vegetable_oils
AOMAOM
... a store building web application for Amazon Associates Azoxymethane, a potent carcinogen Academy of Music (disambiguation) ...
https://en.wikipedia.org/wiki/AOM
EflornithineEflornithine
... azoxymethane, methylnitrosourea, and hydroxybutylnitrosamine in the brain, spinal cord, intestine, mammary gland, and urinary ...
https://en.wikipedia.org/wiki/Eflornithine
Index of oncology articlesIndex of oncology articles
... azoxymethane - AZQ - AZT B cell - B lymphocyte - B3 antigen - B43-PAP immunotoxin - B7-1 - Bacillus Calmette Guérin - bacterial ...
https://en.wikipedia.org/wiki/Index_of_oncology_articles
C2H6N2OC2H6N2O
The molecular formula C2H6N2O (molar mass: 74.08 g/mol, exact mass: 74.0480 u) may refer to: Azoxymethane (AOM) Glycinamide N- ...
https://en.wikipedia.org/wiki/C2H6N2O
Azoxymethane-induced Colon Cancer in Rats Fed Varying Levels of Bean(Phaseolous vulgaris) Dietary Fiber - American Institute...Azoxymethane-induced Colon Cancer in Rats Fed Varying Levels of Bean(Phaseolous vulgaris) Dietary Fiber - American Institute...
Azoxymethane-induced Colon Cancer in Rats Fed Varying Levels of Bean(Phaseolous vulgaris) Dietary Fiber. ...
https://www.aicr.org/research/projects/azoxymethane-induced-colon-cancer-in-rats-fed-varying-levels-of-beanphaseolous-vulgaris-dietary-fiber/
IMSEAR at SEARO: Inhibition of azoxymethane-induced DNA adduct formation by Aloe arborescens var. natalensis.
Shimpo K, Chihara T, Beppu H, Ida C, Kaneko T, Hoshino M, Kuzuya H. Inhibition of azoxymethane-induced DNA adduct formation by ... To clarify the possible mechanisms of inhibition of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in the rat colorectum ... Inhibition of azoxymethane-induced DNA adduct formation by Aloe arborescens var. natalensis. ...
https://imsear.searo.who.int/handle/123456789/38059?locale=en
R-flurbiprofen suppresses distal non-mucin-producing colorectal tumours in azoxymethane treated rats, without suppressing...R-flurbiprofen suppresses distal non-mucin-producing colorectal tumours in azoxymethane treated rats, without suppressing...
R-flurbiprofen suppresses distal non-mucin-producing colorectal tumours in azoxymethane treated rats, without suppressing ... R-flurbiprofen suppresses distal non-mucin-producing colorectal tumours in azoxymethane treated rats, without suppressing ... R-flurbiprofen suppresses distal non-mucin-producing colorectal tumours in azoxymethane treated rats, without suppressing ...
https://fac.flinders.edu.au/items/208c67c3-8db5-43c7-9132-ca37015a70a0
An Optimized Protocol of Azoxymethane-Dextran Sodium Sulfate Induced Colorectal Tumor Model in Mice
... Liang Xi, Hu Jingnan, He ... Since azoxymethane (AOM)-dextran sodium sulfate (DSS) induced tumorigenesis was used to explore inflammation-associated ... An Optimized Protocol of Azoxymethane-Dextran Sodium Sulfate Induced Colorectal Tumor Model in Mice[J].Chinese Medical Sciences ... A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci ...
http://cmsj.cams.cn/EN/10.24920/003495
Nutrients | Free Full-Text | Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals...Nutrients | Free Full-Text | Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals...
Hong, M.Y.; Nulton, E.; Shelechi, M.; Hernández, L.M.; Nemoseck, T. Effects of dark chocolate on azoxymethane-induced colonic ... a The arrow indicates an increase (↑) or decrease (↓). AOM: azoxymethane.; DSS: dextran sulfate sodium; FAK: focal adhesion ... Cocoa polyphenols prevent inflammation in the colon of 2 azoxymethane-treated rats and in TNF-α-stimulated Caco-2 cells. Br. J ... it has been observed that dietary cocoa inhibits colitis-associated cancer in a mouse model of azoxymethane (AOM)/DSS-induced ...
https://www.mdpi.com/2072-6643/8/4/212/htm
Tocotrienol: Delta | GreenMedInfo | Substance | Natural MedicineTocotrienol: Delta | GreenMedInfo | Substance | Natural Medicine
Chemoprevention of azoxymethane-induced colon carcinogenesis by delta-tocotrienol.Dec 31, 2018. ...
https://greenmedinfo.com/substance/tocotrienol-delta
In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis -...
Dive into the research topics of In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse ... In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis. ...
https://experts.arizona.edu/en/publications/in-vivo-molecular-mapping-of-the-tumor-microenvironment-in-an-azo/fingerprints/
Klara KOSTOVCIKOVA | PhD | The Czech Academy of Sciences, Prague | AVCR | Laboratory of Cellular and Molecular ImmunologyKlara KOSTOVCIKOVA | PhD | The Czech Academy of Sciences, Prague | AVCR | Laboratory of Cellular and Molecular Immunology
P159 Azoxymethane-Induced Colon Cancer Development in Mouse Model of Human IBD ...
https://www.researchgate.net/profile/Klara-Kostovcikova
Jennifer Chois Research | CureHunterJennifer Choi's Research | CureHunter
AzoxymethaneIBA 10/2015. 1. MicroRNAs (MicroRNA)IBA 10/2015. 1. Dextrans (Dextran)FDA Link 10/2015. ...
https://www.curehunter.com/public/authorSummary-Choi,%20Jennifer.do
Chemopreventive Effect of Curcumin, a Naturally Occurring Anti-Inflammatory Agent, during the Promotion/Progression Stages of...Chemopreventive Effect of Curcumin, a Naturally Occurring Anti-Inflammatory Agent, during the Promotion/Progression Stages of...
Reddy B. S., Rao C. V., Rivenson A., Kelloff G. Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in ... Rao C. V., Simi B., Reddy B. S. Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine ... The abbreviations used are: TPA, 12-O-tetradecanoylphorbol-13-acetate; AOM, azoxymethane; COX, cyclooxygenase; PG, ... injections of azoxymethane (AOM) at a dose rate of 15 mg/kg body weight per week. Animals destined for the promotion/ ...
https://aacrjournals.org/cancerres/article/59/3/597/505802/Chemopreventive-Effect-of-Curcumin-a-Naturally
Pimiento: MedlinePlus suplementosPimiento: MedlinePlus suplementos
Yoshitani, S. I., Tanaka, T., Kohno, H., and Takashima, S. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by ...
https://medlineplus.gov/spanish/druginfo/natural/945.html
Philippe Gros | School of Biomedical Sciences - McGill UniversityPhilippe Gros | School of Biomedical Sciences - McGill University
In this new project, we have used chemical carcinogenesis with azoxymethane (AOM) to induce colorectal tumors in mice. We have ...
https://www.mcgill.ca/sbms/philippe-gros
Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic ViewEssential Oils and Their Constituents as Anticancer Agents: A Mechanistic View
Dietary intake of POH results in decreasing the tumours induced by Azoxymethane- (AOM-) induced colon cancer [59]. It prevents ...
https://www.hindawi.com/journals/bmri/2014/154106/
CAPSICUM - Therapeutic Powerhouse and Herbal Catalyst... - ArticleCAPSICUM - Therapeutic Powerhouse and Herbal Catalyst... - Article
"The effect of chile ingestion of gastrointestinal mucosal proliferation and azoxymethane-induced cancer in the rat." Journal of ...
https://vitanetonline.com/forums/1/Thread/363
Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress | BMC Cancer |...Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress | BMC Cancer |...
Atg5 flox/flox /K19 CreERT mice were first treated with azoxymethane/dextran sodium sulfate and then injected with tamoxifen to ... Atg5flox/flox/K19CreERT mice were first treated with azoxymethane/dextran sodium sulfate and then injected with tamoxifen to ... Autophagic inhibition in azoxymethane/dextran sodium sulfate (AOM/DSS)-derived mice colon tumors using the CreERT system. a ... CK19 and Atg5 expression in normal colonic mucosa and azoxymethane/dextran sodium sulphate (AOM/DSS)-derived colon tumors. a ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1789-5
Capsicum: Health Benefits, Side Effects, Uses, Dose & PrecautionsCapsicum: Health Benefits, Side Effects, Uses, Dose & Precautions
Yoshitani, S. I., Tanaka, T., Kohno, H., and Takashima, S. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by ...
https://www.rxlist.com/capsicum/supplements.htm
World Journal of Gastroenterology - Baishideng Publishing GroupWorld Journal of Gastroenterology - Baishideng Publishing Group
Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis ...
https://www.wjgnet.com/1007-9327/CitedArticlesInF6?id=10.1097%2Fmd.0000000000004387
JCI Insight - The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancerJCI Insight - The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
We induced CAC in Phd1-/-, Phd2+/-, Phd3-/-, and WT mice with azoxymethane (AOM) and dextran sodium sulfate (DSS). Phd1-/- mice ...
https://insight.jci.org/articles/view/153337/pdf
WikiGenes - artepillin - (E)-3-[4-hydroxy-3,5-bis(3-methylbut-2...WikiGenes - artepillin - (E)-3-[4-hydroxy-3,5-bis(3-methylbut-2...
Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon. Shimizu, K., Das, ...
https://www.wikigenes.org/e/chem/e/5472440.html
Report a CitationReport a Citation
Determination of Antioxidant Contents in Red Sorrel and its nticarcinogenic Potential in Azoxymethane-Induced Colonic Aberrant ...
https://scialert.net/fulltext/reportcitation.php?doi=rjphyto.2008.69.76
Is Grapefruit Ok on The Candida Diet?
Grapefruit juice suppresses azoxymethane-induced colon aberrant crypt formation and induces antioxidant capacity in mice. Asian ...
https://www.yeastinfectionadvisor.com/grapefruit.html
Prebiotics and ProbioticsPrebiotics and Probiotics
... with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane- ...
https://caloriecontrol.org/prebiotics-and-probiotics/
Bifidobacteria: Uses, Side Effects, Dose, Health Benefits, Precautions & WarningsBifidobacteria: Uses, Side Effects, Dose, Health Benefits, Precautions & Warnings
Challa, A., Rao, D. R., Chawan, C. B., and Shackelford, L. Bifidobacterium longum and lactulose suppress azoxymethane-induced ... Kulkarni, N. and Reddy, B. S. Inhibitory effect of Bifidobacterium longum cultures on the azoxymethane-induced aberrant crypt ...
https://www.emedicinehealth.com/bifidobacteria/vitamins-supplements.htm
HERBS: Milk ThistleHERBS: Milk Thistle
Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male ...
https://allnutritionals.com/herbs/herbs-18.php
Selenium: Important for Colon Cancer PreventionSelenium: Important for Colon Cancer Prevention
Soullier, B, Wilson, P, and Nigro, N: "Effect of selenium on azoxymethane-induced intestinal cancer in rats fed a high fat diet ... Fiala, E, Joseph, C, Sohn, O, El-Bayoumy, K, and Reddy, B: "Mechanism of benzylselenocyanate inhibition of azoxymethane-induced ... Reddy, B, Tanaka, T, and El-Bayoumy, K: "Inhibitory effect of dietary p-methoxybenzeneselenol on azoxymethane-induced colon and ... "Effect of Beta-Carotene and Wheat Bran Fiber on Colonic Aberrant Crypt and Tumor Formation in Rats Exposed to Azoxymethane and ...
https://www.dynamicchiropractic.com/mpacms/dc/article.php?id=54000
Hypothalamic beta-endorphin neurons suppress preneoplastic and neoplastic lesions development in 1,2-dimethylhydrazine induced...Hypothalamic beta-endorphin neurons suppress preneoplastic and neoplastic lesions development in 1,2-dimethylhydrazine induced...
Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane. Cancer. ...
https://jcancer.org/v08p3105.htm
Good Proteins, Bad Proteins: The Amino Acids in Health and Disease - 180 Degree HealthGood Proteins, Bad Proteins: The Amino Acids in Health and Disease - 180 Degree Health
2014;78(4):672-9. Bovine milk-derived ?-lactalbumin inhibits colon inflammation and carcinogenesis in azoxymethane and dextran ...
https://180degreehealth.com/amino-acids-metabolic-syndrome/
Bisphenol A is a carcinogen that induces lipid accumulation, peroxisome proliferator‑activated receptor‑γ expression and liver...Bisphenol A is a carcinogen that induces lipid accumulation, peroxisome proliferator‑activated receptor‑γ expression and liver...
Jucá MJ, Bandeira BC, Carvalho DS and Leal AT: Comparative study of 1,2-dimethylhydrazine and azoxymethane on the induction of ...
https://www.spandidos-publications.com/10.3892/etm.2022.11671/abstract
School of Nutrition and Health Sciences - Research output - Taipei Medical University
Inhibits azoxymethane-induced colon carcinogenesisAberrant crypt fociCarcinogenesisSodium sulfateColorectalRatsSulfateMiceFormationCarcinogenesisSulfate sodiumMiceInhibitsLesionsTumorSodium sulfate-inducedOrnithine DecarboxylaseDextran sodium sulphateAberrant cryptsColonic tumorsColorectalCarcinogenicRodentExperimentalLipidFoci developmentInjectionsCancerExtractVersusEvaluationStudyDevelopmentPercentageExpressionShownWeeksEffectPatients
Inhibits azoxymethane-induced colon carcinogenesis1
  • Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats. (allnutritionals.com)
Aberrant crypt foci1
  • To clarify the possible mechanisms of inhibition of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in the rat colorectum by freeze-dried whole leaves of Aloe arborescens var. (who.int)
Carcinogenesis3
  • Since azoxymethane (AOM)-dextran sodium sulfate (DSS) induced tumorigenesis was used to explore inflammation-associated carcinogenesis of sporadic colorectal cancer (CRC), different administration modes of AOM or DSS have been reported. (cams.cn)
  • Chemoprevention of azoxymethane-induced colon carcinogenesis by delta-tocotrienol. (greenmedinfo.com)
  • The protective role of Urtica dioica seed extract against azoxymethane-induced colon carcinogenesis. (allyoucanfind.club)
Sodium sulfate3
  • An Optimized Protocol of Azoxymethane-Dextran Sodium Sulfate Induced Colorectal Tumor Model in Mice[J].Chinese Medical Sciences Journal, 2019, 34(4): 281-288. (cams.cn)
  • Atg5 flox/flox /K19 CreERT mice were first treated with azoxymethane/dextran sodium sulfate and then injected with tamoxifen to inhibit autophagy in CK19-positive epithelial cells. (biomedcentral.com)
  • We induced CAC in Phd1-/-, Phd2+/-, Phd3-/-, and WT mice with azoxymethane (AOM) and dextran sodium sulfate (DSS). (jci.org)
Colorectal2
  • R-flurbiprofen suppresses distal non-mucin-producing colorectal tumours in azoxymethane treated rats, without suppressing eicosanoid production. (edu.au)
  • Repeated DSS cycling in combination with treatment with azoxymethane, a genotoxic agent, induced colitis-dependent neoplasia, generating a commonly used model for colorectal neoplasia and cancer in humans [ 10 ]. (biomedcentral.com)
Rats1
  • At 7 and 8 weeks of age, rats intended for carcinogen treatment were given s.c. injections of azoxymethane (AOM) at a dose rate of 15 mg/kg body weight per week. (aacrjournals.org)
Sulfate1
  • Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model. (wjgnet.com)
Mice1
  • Azoxymethane (AOM), a derivative of 1, 2-Dimethyl hydrazine (DMH) was used for the induction of CRC in Balb/C mice. (pharmacognosy.in)
Formation1
  • IMSEAR at SEARO: Inhibition of azoxymethane-induced DNA adduct formation by Aloe arborescens var. (who.int)
Carcinogenesis13
  • This study was conducted to analyze the concentration of cell-free DNA (cfDNA) as a tumor marker in colorectal carcinogenesis by using blood serum samples from BALB/c mice previously induced by azoxymethane (AOM) and promoted by dextran sodium sulfate (DSS). (ui.ac.id)
  • 1. Protective role of a melon superoxide dismutase combined with gliadin (GliSODin) on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis. (nih.gov)
  • 2. Amelioration of azoxymethane induced-carcinogenesis by reducing oxidative stress in rat colon by natural extracts. (nih.gov)
  • 4. Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis. (nih.gov)
  • 8. Protective Effects of Turbinaria ornata and Padina pavonia against Azoxymethane-Induced Colon Carcinogenesis through Modulation of PPAR Gamma, NF-κB and Oxidative Stress. (nih.gov)
  • 10. Brewers' rice modulates oxidative stress in azoxymethane-mediated colon carcinogenesis in rats. (nih.gov)
  • 12. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate. (nih.gov)
  • 13. Effects of Grape Juice in Superoxide Dismutase and Catalase in Colorectal Cancer Carcinogenesis Induced by Azoxymethane. (nih.gov)
  • 14. Chemopreventive effect of 2-(allylthio)pyrazine (2-AP) on rat colon carcinogenesis induced by azoxymethane (AOM). (nih.gov)
  • 15. Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane. (nih.gov)
  • 18. Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition. (nih.gov)
  • Methods: In mice, C57BL/6 mice were given azoxymethane/dextran sulfate sodium to establish the UC carcinogenesis model. (archive.org)
  • In another study, grape seed proanthocyanidins were found to reduce azoxymethane-induced colon carcinogenesis in mice by inducing apoptosis . (healwithfood.org)
Sulfate sodium4
  • However, the effect of a combined treatment of microencapsulated BF and LYC on IGF-1/IGF-1R/IGFBPs (Insulin-like growth factor-binding proteins) expression in an azoxymethane (AOM)-dextran sulfate sodium (DSS)-induced CRC model have not been demonstrated. (greenmedinfo.com)
  • METHODS The CAC model in mice was established by azoxymethane (AOM) combined and dextran sulfate sodium salt (DSS), accompanied by treat?ment with various dosages of UA and concomitant appraisal of body weight, stool and physical state of the mice. (bvsalud.org)
  • Also this was the first study is first of its kind in an Azoxymethane(AOM)/DSS (Dextran sulfate sodium)-induced CAC. (boswellin.com)
  • Jin, D. Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome. (chagahealth.eu)
Mice7
  • Second, ACF formation was evaluated in azoxymethane (AOM)-induced CF-1 mice. (nih.gov)
  • We now show that SPL is also downregulated in tumors that develop in azoxymethane/dextran sodium sulfate (AOM/DSS)-treated mice. (nih.gov)
  • Here we demonstrate that nullizygous PKCβ (PKCβKO) mice are highly resistant to azoxymethane (AOM)-induced preneoplastic lesions, aberrant crypt foci. (elsevier.com)
  • These mice were crossed with adenomatous polyposis coli (Apc) min/+ mice, or given azoxymethane followed by dextran sodium sulfate, to assess intestinal tumor formation. (elsevier.com)
  • iVP16LXRα mice formed fewer, smaller tumors than VP16 (control) mice after administration of azoxymethane and dextran sodium sulfate. (elsevier.com)
  • Azoxymethane (AOM), a derivative of 1, 2-Dimethyl hydrazine (DMH) was used for the induction of CRC in Balb/C mice. (phcog.com)
  • 1,2-dimethylhydrazine (DMH) and its own metabolite azoxymethane (AOM) were procarcinogens widely used to produce a cancerous colon in mice (DMH/AOM rat unit). (marchongoogle.com)
Inhibits1
  • In contrast, we have demonstrated previously that another bile acid, ursodeoxycholic acid (UDCA), inhibits the development of azoxymethane (AOM)-induced colon cancer in rats. (aacrjournals.org)
Lesions3
  • 21 ] In this experimental system, azoxymethane increased premalignant and malignant lesions in the mouse colon. (communitybasedispensary.org)
  • Animals treated with azoxymethane and CBD concurrently were protected from developing premalignant and malignant lesions. (communitybasedispensary.org)
  • Abstract Purpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM). (scielo.org)
Tumor2
  • Here, we assessed the potential benefit of whole walnut consumption in a mouse tumor bioassay using azoxymethane. (aacrjournals.org)
  • In this study, TrkC was frequently overexpressed in CRC cells, patients' tumor samples and an azoxymethane/dextran sulphate sodium-induced mouse model of colitis-associated CRCs. (oncotarget.com)
Sodium sulfate-induced1
  • 3. Whey protein versus whey protein hydrolyzate for the protection of azoxymethane and dextran sodium sulfate induced colonic tumors in rats. (anadolusaglik.org)
Ornithine Decarboxylase1
  • 16. Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. (nih.gov)
Dextran sodium sulphate1
  • The results were supported by data obtained from an AOM/DSS (azoxymethane/dextran sodium sulphate) colon cancer mouse model and from human colon cancer biopsy specimens colonised by pks + E. coli or pks− E. coli . (bmj.com)
Aberrant crypts1
  • The effects of dietary selenomethionine on polyamines and azoxymethane-induced aberrant crypts. (nih.gov)
Colonic tumors1
  • Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. (vanderbilt.edu)
Colorectal4
  • The researchers investigated the effect of folic acid supplementation on colorectal cancer risk in the offspring of an azoxymethane rat model of colorectal cancer. (medscape.com)
  • Background Escherichia coli strains harbouring the pks island ( pks + E. coli ) are often seen in human colorectal tumours and have a carcinogenic effect independent of inflammation in an AOM/IL-10 −/− (azoxymethane/interleukin) mouse model. (bmj.com)
  • Colibactin-producing E. coli promote colorectal cancer in a murine AOM/IL-10 −/− (azoxymethane/interleukin) mouse model. (bmj.com)
  • A well-established mouse style of colorectal cancers that has the to provide understanding into the function of aberrant DNA methylation in the molecular pathogenesis from the polypcancer development sequence may be the azoxymethane (AOM) rodent cancer of the colon model. (cylch.org)
Carcinogenic2
  • We evaluated the effects of dietary selenomethionine supplementation on colonic polyamine levels and the ability of L-selenomethionine supplementation to modulate the carcinogenic activity of azoxymethane (AOM) in the rat colon. (nih.gov)
  • DMH and its carcinogenic metabolites [azoxymethane (AOM) and naethylazoxymethanol] are the most commonly used compounds to study morphology, pathogenesis, prevention and treatment of experimentally induced colonic tumours ( 7 - 9 ). (iiarjournals.org)
Rodent1
  • Consequently, we assessed the role of aberrant DNA methylation in the azoxymethane (AOM) rodent model of colon cancer. (nih.gov)
Experimental1
  • Once a week for 2 weeks, animals on control groups received saline, while animals in experimental groups received azoxymethane (15 mg/kg i.p. (scielo.org)
Lipid1
  • This study compares the lipid profile of azoxymethane (AOM) induced colon polyps to that of the surrounding mucosa tissue in rats fed a diet high in n-6 PUFA. (uwc.ac.za)
Foci development1
  • 3. Dietary folate protects against azoxymethane-induced aberrant crypt foci development and oxidative stress in rat colon. (nih.gov)
Injections3
  • All animals were given s.c. injections of 7.4 mg azoxymethane (AOM) per kg body weight once a week for 11 weeks and followed for an additional 20 weeks. (aacrjournals.org)
  • At 5 and 6 weeks, the rats received 2 subcutaneous injections of azoxymethane. (medscape.com)
  • At the end of the 5th week of feeding (end of 11th week of age), all rats received 2 subcutaneous injections of azoxymethane carcinogen at 15 mg/kg rat body weight per dose once a week for 2 consecutive weeks. (greenmedinfo.com)
Cancer5
  • 7. Pomegranate (Punica granatum) peel extract efficacy as a dietary antioxidant against azoxymethane-induced colon cancer in rat. (nih.gov)
  • Furthermore, animal models of colon cancer induced by azoxymethane (AOM) and dextran sultato sodium (DSS) show the maintenance of an inflammatory state during tumorigenesis. (fapesp.br)
  • A key in vivo finding was that compared with the whole American ginseng extract, the hexane fraction of American ginseng was more potent in treating colitis in a dextran sodium sulfate (DSS) mouse model, as well as suppressing azoxymethane/DSS-induced colon cancer. (uthscsa.edu)
  • The two groups were exposed to an azoxymethane a carcinogen used to promote colon cancer. (healthdigezt.com)
  • Curcumin in the dietary plan of male F344 rats was proven to decrease the occurrence of azoxymethane (AOM)-induced cancer of the colon, from 81% to 47% [24]. (bioclaro.com)
Extract2
  • The aim of this research is to assess the chemoprotective outcomes of A. ilicifolius ethanolic extract against azoxymethane (AOM) induced colonic aberrant crypt foci (ACF) in rats. (figshare.com)
  • Our previous studies demonstrated that oral administration of Gold Lotion (GL), an extract of multiple varieties of citrus peels containing abundant flavonoids , including a large percentage of polymethoxyflavones (PMFs), effectively suppressed azoxymethane (AOM)-induced colonic tumorigenesis. (rsc.org)
Versus1
  • BCD) Identified biomarker threshold ( 0.01 versus 0.01) was Azoxymethane tested in baseline mRNA samples from patients in the RAVE trial as a predictor of complete remission at 6 months (B), 12 months (C), and 18 months (D), in subjects treated with RTX (blue bars) versus CYC (red bars). (biotechpolicy.org)
Evaluation2
  • Genetic Toxicity Evaluation of Azoxymethane in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
  • Almagrami, A. A., M. A. Alshawsh, R. Saif-Ali, A. Shwter, S. D. Salem and M. A. Abdulla (2014) Evaluation of Chemopreventive Effects of Acanthus ilicifolius against Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon. (sussex.ac.uk)
Study1
  • An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Azoxymethane (25843-45-2). (nih.gov)
Development2
  • A TNF- Azoxymethane promoter SNP (-308) has also been associated with the development of the disease and aggressive periodontitis [16]. (nsdfu.org)
  • Azoxymethane (AOM) can be commonly used to induce tumors in the distal digestive tract of rodents by leading to O6-methyl-guanine development (7). (ly2886721.com)
Percentage1
  • The number on the top of the bars in BCD denotes percentage remission rate in each subgroup, the number in Azoxymethane brackets refers to the total number of subjects in each respective subgroup, and the number above it refers to the number of remitters. (biotechpolicy.org)
Expression1
  • Application of this threshold resulted Azoxymethane in a significant enrichment for responders in the expression was associated with CR at 6 months (= 0.016) (Figure 2B). (biotechpolicy.org)
Shown1
  • IL-4, IL-6, IL-8 and IL-18 located in different regions of the mentioned Azoxymethane cytokine genes have been shown to affect the risk of the disease in several populations [8-12]. (nsdfu.org)
Weeks1
  • After 17 weeks of the last azoxymethane injection (from 12th to 29th week of age), all rats were euthanized. (greenmedinfo.com)
Effect1
  • Chemopreventive effect of raw and cooked lentils (Lens culinaris L) and soybeans (Glycine max) against azoxymethane-induced aberrant crypt foci. (greenmedinfo.com)
Patients1
  • Table 1 levels at baseline Azoxymethane in all patients and in patients achieving complete remission at 6, 12, and 18 months Open in a separate window Examining the baseline characteristics between = 0.03) and PR3+ (= 0.01), respectively (Table 2). (biotechpolicy.org)
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