Azoospermia: A condition of having no sperm present in the ejaculate (SEMEN).Oligospermia: A condition of suboptimal concentration of SPERMATOZOA in the ejaculated SEMEN to ensure successful FERTILIZATION of an OVUM. In humans, oligospermia is defined as a sperm count below 20 million per milliliter semen.Sperm Retrieval: Procedures to obtain viable sperm from the male reproductive tract, including the TESTES, the EPIDIDYMIS, or the VAS DEFERENS.Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.Chromosomes, Human, Y: The human male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans.Testis: The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.Spermatogenesis: The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA.Seminal Plasma Proteins: Proteins found in SEMEN. Major seminal plasma proteins are secretory proteins from the male sex accessory glands, such as the SEMINAL VESICLES and the PROSTATE. They include the seminal vesicle-specific antigen, an ejaculate clotting protein; and the PROSTATE-SPECIFIC ANTIGEN, a protease and an esterase.Spermatozoa: Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.Sperm Count: A count of SPERM in the ejaculum, expressed as number per milliliter.Testicular Diseases: Pathological processes of the TESTIS.Sperm Injections, Intracytoplasmic: An assisted fertilization technique consisting of the microinjection of a single viable sperm into an extracted ovum. It is used principally to overcome low sperm count, low sperm motility, inability of sperm to penetrate the egg, or other conditions related to male infertility (INFERTILITY, MALE).Sex Chromosome Disorders of Sex Development: Congenital conditions of atypical sexual development associated with abnormal sex chromosome constitutions including MONOSOMY; TRISOMY; and MOSAICISM.Sex Chromosome Aberrations: Abnormal number or structure of the SEX CHROMOSOMES. Some sex chromosome aberrations are associated with SEX CHROMOSOME DISORDERS and SEX CHROMOSOME DISORDERS OF SEX DEVELOPMENT.Klinefelter Syndrome: A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).Y Chromosome: The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.Vasovasostomy: Surgical anastomosis or fistulization of the spermatic ducts to restore fertility in a previously vasectomized male.Microsurgery: The performance of surgical procedures with the aid of a microscope.Semen: The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma.Vasectomy: Surgical removal of the ductus deferens, or a portion of it. It is done in association with prostatectomy, or to induce infertility. (Dorland, 28th ed)Reproductive Techniques: Methods pertaining to the generation of new individuals, including techniques used in selective BREEDING, cloning (CLONING, ORGANISM), and assisted reproduction (REPRODUCTIVE TECHNIQUES, ASSISTED).Contraceptive Agents, Male: Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.Spermatids: Male germ cells derived from the haploid secondary SPERMATOCYTES. Without further division, spermatids undergo structural changes and give rise to SPERMATOZOA.Sequence Tagged Sites: Short tracts of DNA sequence that are used as landmarks in GENOME mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database.Sperm Motility: Movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression.Epididymis: The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.Semen Analysis: The quality of SEMEN, an indicator of male fertility, can be determined by semen volume, pH, sperm concentration (SPERM COUNT), total sperm number, sperm viability, sperm vigor (SPERM MOTILITY), normal sperm morphology, ACROSOME integrity, and the concentration of WHITE BLOOD CELLS.Suction: The removal of secretions, gas or fluid from hollow or tubular organs or cavities by means of a tube and a device that acts on negative pressure.Vas Deferens: The excretory duct of the testes that carries SPERMATOZOA. It rises from the SCROTUM and joins the SEMINAL VESICLES to form the ejaculatory duct.XYY Karyotype: Abnormal genetic constitution in males characterized by an extra Y chromosome.Varicocele: A condition characterized by the dilated tortuous veins of the SPERMATIC CORD with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.Tissue and Organ Harvesting: The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.Ejaculation: The emission of SEMEN to the exterior, resulting from the contraction of muscles surrounding the male internal urogenital ducts.Cryopreservation: Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.Follicle Stimulating Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.Chromosome Deletion: Actual loss of portion of a chromosome.Genetic Loci: Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.Embryo Transfer: The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO.Pregnancy Rate: The ratio of the number of conceptions (CONCEPTION) including LIVE BIRTH; STILLBIRTH; and fetal losses, to the mean number of females of reproductive age in a population during a set time period.Ejaculatory Ducts: Paired ducts in the human male through which semen is ejaculated into the urethra.Semen Preservation: The process by which semen is kept viable outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Microinjections: The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.Fertilization in Vitro: An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Sertoli Cells: Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.Epitestosterone: The 17-alpha isomer of TESTOSTERONE, derived from PREGNENOLONE via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone is used to monitor anabolic drug abuse.Tuberculosis, Male Genital: MYCOBACTERIUM infections of the male reproductive tract (GENITALIA, MALE).Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Sperm Maturation: The maturing process of SPERMATOZOA after leaving the testicular SEMINIFEROUS TUBULES. Maturation in SPERM MOTILITY and FERTILITY takes place in the EPIDIDYMIS as the sperm migrate from caput epididymis to cauda epididymis.Asthenozoospermia: A condition in which the percentage of progressively motile sperm is abnormally low. In men, it is defined as Fertility: The capacity to conceive or to induce conception. It may refer to either the male or female.Gonadal Dysgenesis, Mixed: A type of defective gonadal development in patients with a wide spectrum of chromosomal mosaic variants. Their karyotypes are of partial sex chromosome monosomy resulting from an absence or an abnormal second sex chromosome (X or Y). Karyotypes include 45,X/46,XX; 45,X/46,XX/47,XXX; 46,XXp-; 45,X/46,XY; 45,X/47,XYY; 46,XYpi; etc. The spectrum of phenotypes may range from phenotypic female to phenotypic male including variations in gonads and internal and external genitalia, depending on the ratio in each gonad of 45,X primordial germ cells to those with normal 46,XX or 46,XY constitution.Inhibins: Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectivelyEpididymitis: Inflammation of the EPIDIDYMIS. Its clinical features include enlarged epididymis, a swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.Cryptorchidism: A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.Pregnancy Outcome: Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.Abnormal Karyotype: A variation from the normal set of chromosomes characteristic of a species.RNA-Binding Proteins: Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.Gene Deletion: A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.Seminiferous Tubules: The convoluted tubules in the TESTIS where sperm are produced (SPERMATOGENESIS) and conveyed to the RETE TESTIS. Spermatogenic tubules are composed of developing germ cells and the supporting SERTOLI CELLS.Desogestrel: A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.Karyotyping: Mapping of the KARYOTYPE of a cell.Genital Diseases, Male: Pathological processes involving the male reproductive tract (GENITALIA, MALE).Reproductive Techniques, Assisted: Clinical and laboratory techniques used to enhance fertility in humans and animals.Adrenal Rest Tumor: Neoplasm derived from displaced cells (rest cells) of the primordial ADRENAL GLANDS, generally in patients with CONGENITAL ADRENAL HYPERPLASIA. Adrenal rest tumors have been identified in TESTES; LIVER; and other tissues. They are dependent on ADRENOCORTICOTROPIN for growth and adrenal steroid secretion.Ostomy: Surgical construction of an artificial opening (stoma) for external fistulization of a duct or vessel by insertion of a tube with or without a supportive stent.Hypogonadism: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).Myoclonic Epilepsies, Progressive: A heterogeneous group of primarily familial disorders characterized by myoclonic seizures, tonic-clonic seizures, ataxia, progressive intellectual deterioration, and neuronal degeneration. These include LAFORA DISEASE; MERRF SYNDROME; NEURONAL CEROID-LIPOFUSCINOSIS; sialidosis (see MUCOLIPIDOSES), and UNVERRICHT-LUNDBORG SYNDROME.Fertilization: The fusion of a spermatozoon (SPERMATOZOA) with an OVUM thus resulting in the formation of a ZYGOTE.Glycerylphosphorylcholine: A component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. (From Stedman, 26th ed) It counteracts the effects of urea on enzymes and other macromolecules.Specimen Handling: Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.Karyotype: The full set of CHROMOSOMES presented as a systematized array of METAPHASE chromosomes from a photomicrograph of a single CELL NUCLEUS arranged in pairs in descending order of size and according to the position of the CENTROMERE. (From Stedman, 25th ed)Infertility: Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility.Chromosome Aberrations: Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.Luteinizing Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.

Constitutional mosaic trisomy 21 and azoospermia: a case report. (1/302)

Constitutional full trisomy 21 is a common disorder in which abnormal spermatogenesis has been previously described. However, constitutional mosaic trisomy 21 in an otherwise normal but infertile male has not been explored. We report a case with low level mosaic trisomy 21 in a non-syndrome but azoospermic patient. We also propose that the patient's azoospermia may be related to the constitutional mosaic trisomy 21 and thus resulting in a late onset of testicular failure.  (+info)

Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia. (2/302)

Although it is generally thought that spermatogenic failure has a genetic background, to date only a limited percentage of men with non-obstructive azoospermia (NOA) are diagnosed with a genetic defect. The only common and well-established genetic causes of NOA in humans are numerical and structural chromosomal abnormalities and Y-chromosome deletions. In addition, some infrequent mutations have been identified in the ubiquitin-specific protease 9, Y-linked (USP9Y) and the synaptonemal complex protein 3 (SYCP3) gene that cause azoospermia. FK506-binding protein 6 (Fkbp6) is a newly discovered component of the synaptonemal complex (SC), which is essential for proper chromosome pairing and meiotic division. A null mutation of the Fkbp6 gene causes azoospermia in mice as well as in rats. We tested the hypothesis whether mutations in this gene can also cause azoospermia in humans. We performed a mutation screen in 51 men with NOA through direct sequencing methods. No homozygous mutations were identified. Two heterozygous mutations (T173T and R183C) were identified, which are likely to disrupt FKBP6 protein function. However, both mutations were also found in a group of 218 normospermic controls indicating that one FKBP6 allele appears to be sufficient for normal spermatogenesis. In conclusion, our results suggest that genetic defects in FKBP6 can be excluded as a common cause of azoospermia in humans.  (+info)

Decrease of both stem cell factor and clusterin mRNA levels in testicular biopsies of azoospermic patients with constitutive or idiopathic but not acquired spermatogenic failure. (3/302)

BACKGROUND: Sertoli cells nurse germ cells during spermatogenesis, and alterations of Sertoli cell functions have been suggested in cases of spermatogenic failures. METHODS: In this work, we measured stem cell factor (SCF) and clusterin mRNA levels, by quantitative RT-PCR, in RNA extracted from testicular biopsies of 49 azoospermic patients classified according to testicular histology as having normal spermatogenesis or spermatogenic failure. RESULTS: When related to the percentage of Sertoli cells counted on a histological section of a neighbouring tissue sample, SCF and clusterin mRNA levels were significantly lower in the 'spermatogenic failure' group compared with the control group (P = 0.0297 and P = 0.0043, respectively). These levels were also significantly lower in the cases of 'constitutive' (cryptorchidism and Yq microdeletion) and 'idiopathic' spermatogenic failures when compared with the control group; conversely, they were not significantly decreased in the group with 'acquired spermatogenic failure' (orchitis, testicular traumatism, chemoradiotherapy and varicocele). CONCLUSIONS: These data further demonstrate an alteration of Sertoli cell functions in some human spermatogenic failures and suggest that a lack of Sertoli cell maturation may be involved in cases of constitutive or idiopathic spermatogenic failures.  (+info)

Association of spermatogenic failure with decreased CDC25A expression in infertile men. (4/302)

BACKGROUND: DAZ gene family is crucial for human spermatogenesis that requires the precise co-ordination of cell cycle events. CDC25A is recognized as the downstream substrate of DAZ gene family and is thought to function on the M-phase regulation of cell cycles. We investigated the expression profiles of CDC25A in the testes of infertile men and evaluated the relationship between CDC25A levels and testicular phenotype, clinical hormonal parameters and sperm retrieval results. METHODS: The protein and mRNA transcript levels of CDC25A in the testes of 40 azoospermic men were determined by immunohistochemistry and quantitative real-time-PCR. CDC25A in human spermatozoa was investigated by western blotting and immunofluorescence staining. RESULTS: The CDC25A protein was expressed mainly in spermatocyte, spermatid and spermatozoa. CDC25A transcript levels were significantly decreased (P = 0.0009) in patients with spermatogenic failure, especially in men with meiotic arrest and Sertoli cell-only syndrome. Significantly higher CDC25A transcript levels were detected in patients with successful sperm retrieval than in patients with failed sperm retrieval (P = 0.005). CONCLUSIONS: Decreased CDC25A is associated with spermatogenic failure and failed sperm retrieval in infertile men. Further studies are necessary to explore the functional roles of CDC25A in human spermatozoa.  (+info)

Beta-endorphin in serum and seminal plasma in infertile men. (5/302)

AIM: To access beta-endorphin levels in serum as well as seminal plasma in different infertile male groups. METHODS: Beta-endorphin was estimated in the serum and seminal plasma by enzyme-linked immunosorbent assay (ELISA) method in 80 infertile men equally divided into four groups: non-obstructive azoospermia (NOA), obstructive azoospermia (OA), congenital bilateral absent vas deferens (CBVAD) and asthenozoospermia. The results were compared to those of 20 normozoospermic proven fertile men. RESULTS: There was a decrease in the mean levels of beta-endorphin in the seminal plasma of all successive infertile groups (mean +/- SD: NOA 51.30 +/- 27.37, OA 51.88 +/- 9.47, CBAVD 20.36 +/- 13.39, asthenozoospermia 49.26 +/- 12.49 pg/mL, respectively) compared to the normozoospermic fertile control (87.23 +/- 29.55 pg/mL). This relation was not present in mean serum level of beta-endorphin between four infertile groups (51.09 +/- 14.71, 49.76 +/- 12.4, 33.96 +/- 7.2, 69.1 +/- 16.57 pg/mL, respectively) and the fertile control group (49.26 +/- 31.32 pg/mL). The CBVAD group showed the lowest seminal plasma mean level of beta-endorphin. Testicular contribution of seminal beta-endorphin was estimated to be approximately 40%. Seminal beta-endorphin showed significant correlation with the sperm concentration (r = 0.699, P = 0.0188) and nonsignificant correlation with its serum level (r = 0.375, P = 0.185) or with the sperm motility percentage (r = 0.470, P = 0.899). CONCLUSION: The estimation of beta-endorphin alone is not conclusive to evaluate male reproduction as there are many other opiates acting at the hypothalamic pituitary gonadal axis.  (+info)

Does PGD for aneuploidy screening change the selection of embryos derived from testicular sperm extraction in obstructive and non-obstructive azoospermic men? (6/302)

BACKGROUND: An increased incidence of aneuploid embryos has been recently described from azoospermic men. The aim of this study was to assess if embryo selection on day 5, based on morphological criteria, would be different from the selection based on PGD for aneuploidy screening (AS) in couples undergoing ICSI for male azoospermia. METHODS: Sixty-two cycles of testicular sperm extraction (TESE)-ICSI with PGD-AS were included in the analysis. Two embryologists, blinded to the PGD-AS results, retrospectively reviewed the available embryology data from day 5 embryos and selected one, two or three embryos to be transferred. These results were compared with the selected embryos based on PGD-AS. RESULTS: A total of 39 cycles from non-obstructive azoospermia (NOA) and 23 cycles from obstructive azoospermia (OA) were retrospectively analysed. If single embryo transfer (SET) had been performed, in 64.8% of the NOA cycles and 54.5% of the OA cycles, no difference in embryo choice would have occurred compared to PGD-AS and in 10.8 and 36.6% of the cycles, respectively, an aneuploid embryo would have been chosen. If double ET (DET) had been performed, in 72.9% of the NOA cycles and 86.5% of the OA cycles, no difference in embryo choice would have occurred compared to PGD-AS and in 2.7 and 4.5% of the cycles, respectively, an aneuploid embryo would have been chosen. If triple ET (TET) had been performed, the outcome would have been the same as for DET. DISCUSSION: Our results suggest that under the terms of an SET policy, the performance of PGD-AS in azoospermia would result in a higher chance of success, as the possibility of selecting a euploid embryo is enhanced.  (+info)

Role of transrectal ultrasonography in the evaluation of azoospermic men with low-volume ejaculate. (7/302)

OBJECTIVE: The purpose of this prospective study was to evaluate the incidence of distal ejaculatory system defects with transrectal ultrasonography (TRUS) among patients evaluated for azoospermia. METHODS: Forty-two patients with low-volume ejaculate and azoospermia were evaluated by physical examination, serum follicle-stimulating hormone and luteinizing hormone level determination, karyotyping, selective screening for cystic fibrosis mutations, and TRUS. RESULTS: On physical examination, in 29 patients (69%), either 1 (12 patients) or both (17 patients) of the vasa deferentia could not be palpated. In the group of 17 patients with bilateral involvement of the vasa deferentia, the ultrasonographic imaging universally showed bilateral absence or hypoplasia of the seminal vesicles with bilateral agenesis of the vasa deferentia and nonvisualization of both ejaculatory ducts. In the patients with a unilateral abnormality on physical examination, the ultrasonographic imaging showed absence of the ipsilateral seminal vesicle in 7 patients and the hypoplastic seminal vesicle in 5. In the group of 13 patients with normal physical examination findings, a variety of obstructive causes were diagnosed by TRUS examination. CONCLUSIONS: According to this study, TRUS appears to be a sensitive method for evaluating the anatomy of the distal ejaculatory system. Its safety and low costs make it a good alternative to the other invasive and expensive methods.  (+info)

Can inhibin-B predict the outcome of microsurgical epididymal sperm aspiration in patients with suspected primary obstructive azoospermia. (8/302)

AIM: To evaluate whether inhibin-B can predict the outcome of a microsurgical epidymal sperm aspiration (MESA) procedure in patients with suspected primary obstructive azoospermia (OA) and if inhibin-B can replace testicular biopsy in the diagnostic work-up of these patients. METHODS: Inhibin-B levels and testicular biopsy scores were related to the outcome of MESA in 43 patients with suspected primary OA. MESA was considered to be successful when epididymal sperm could be identified during the procedure. RESULTS: Spermatozoa were present in the epididymal aspirate in 28 out of the 43 patients (65%). Inhibin-B values were not significantly different in patients with successful or unsuccessful MESA. The modified Johnsen score, however, was significantly lower in patients with unsuccessful MESA (P = 0.003). A rete testis obstruction or epididymal malfunctioning was found in 15% of patients with suspected primary OA, reflected by unsuccessful MESA despite normal inhibin-B levels and normal testicular histology. CONCLUSION: Inhibin-B cannot replace testicular biopsy as a diagnostic tool in the work-up of patients with suspected primary OA. Testicular biopsy is useful in identifying patients with spermatogenic arrest, who might have normal inhibin-B values.  (+info)

PINA-NETO, J.M. et al. Somatic cytogenetic and azoospermia factor gene microdeletion studies in infertile men. Braz J Med Biol Res [online]. 2006, vol.39, n.4, pp.555-561. ISSN 1414-431X. http://dx.doi.org/10.1590/S0100-879X2006000400017.. The objective of the present study was to determine the frequency of somatic chromosomal anomalies and Y chromosomal microdeletions (azoospermia factor genes, AZF) in infertile males who seek assisted reproduction. These studies are very important because the assisted reproduction techniques (mainly intracytoplasmic sperm injection) bypass the natural selection process and some classical chromosomal abnormalities, microdeletions of AZF genes or some deleterious genic mutations could pass through generations. These genetic abnormalities can cause in the offspring of these patients male infertility, ambiguous external genitalia, mental retardation, and other birth defects. We studied 165 infertile men whose infertility was attributable to testicular problems (60 ...
It is a simple, minimal invasive procedure that allows the clinician to gain information regarding spermatogenesis.. The appropriate management of azoospermia requires differentiation between obstructive and non-obstructive azoospermia.. It helps in differentiating between obstructive and non obstructive azoospermia. Testicular biopsy can provide a definitive diagnosis of non obstructive azoospermia.. Non obstructive azoospermia present with abnormal spermatogenesis.. It can be used to retrieve sperm in men with azoospermia. It can be performed under local or general anesthesia.. ...
Distinction between obstructive and non-obstructive azoospermiaPrior to initiating treatment for a couple, in whom the man has azoospermia, it is important to distinguish whether the lack of sperm in the ejaculate is from an obstructive or non-obstructive process. In addition, careful evaluation of the post-ejaculate urinalysis is necessary to rule out retrograde ejaculation, common in diabetics.
Alexander N. Yatsenko, M.D., Ph.D., Andrew P. Georgiadis, B.A.D., Andrea J. Berman, Ph.D., Thomas Jaffe, M.D., Marta Olszewska, Ph.D.D., Joseph Sanfilippo, M.D., Maciej Kurpisz, M.D., Ph.D., Aleksandar Rajkovic, M.D., Ph.D., Svetlana A. Yatsenko, M.D., Sabine Kliesch, M.D., Stefan Schlatt, Ph.D.D.: X-Linked TEX11 Mutations, Meiotic Arrest, and Azoospermia in Infertile Men Nearly half of most cases of male infertility are usually associated with genetic defects.1-3 Up to 20 percent of infertile men receive a analysis of azoospermia.3 Nonobstructive azoospermia is spermatogenic failure that is defined by the lack of spermatozoa in the ejaculate.1,4 Azoospermia is a heterogeneous condition with several histologic phenotypes.6,7 Azoospermia with meiotic arrest is a milder type of infertility with a cessation at the spermatocyte stage of germ-cell development.The types of addictions are as follows: * Drug Addiction * Food Addiction * Alcoholism * Internet Addiction * Sexual Addiction * Buying ...
Round spermatid injection (ROSI) is a technique of assisted reproduction whereby a round spermatid is injected into oocyte cytoplasm in order to achieve fertilization. This technique can be used to enable genetic fatherhood to some men who have no spermatozoa in the ejaculate (azoospermia) and in whom spermatozoa cannot be obtained surgically from the testicles. This condition is called nonobstructive or secretory azoospermia, as opposed to obstructive azoospermia, in which complete sperm production does occur in the testicles, and potentially fertilizing spermatozoa can be obtained by testicular sperm extraction (TESE) and used for ICSI. In cases of nonobstructive (secretory) azoospermia, on the other hand, testicular sperm production is blocked at different stages of the process of sperm formation (spermatogenesis). In those men in whom spermatogenesis is blocked at the stage of round spermatids, in which meiosis has already been completed, these round cells can successfully fertilize oocytes ...
I would like to know whether obstructive azoospermia can be cured by homeopathic medicine or not. Testicular biopsy and hormone reports are normal so
Online Doctor Chat - Treatment for Obstructive azoospermia, Ask a Doctor about diagnosis, treatment and medication for Infertility, Online doctor patient chat conversation by Dr. Chakravarthy Mazumdar
I am suffering from obstructive azoospermia. Following is my biopsy and other reportsoutcome: (1) A SMALL CYST OF 8 # 5 M.M. IS SEEN AT PERIURETHRAL
A cohort study of 2,238 men who were evaluated for infertility at a clinic in Texas from 1989 to 2009 found that those men who had azoospermia, a condition in which no measurable sperm is present, had a 2.2-fold higher cancer risk compared with those who were nonazoospermic. The study was published online in the journal Fertility and Sterility.1. Study Details. In all, 451 men had azoospermia and 1,787 were not azoospermic (mean age at evaluation = 35.7 years). The researchers found 29 cases of cancer, including testicular, prostate, and intestinal cancers, as well as lymphoma and melanoma, during an average follow-up of nearly 7 years.. The standardized incidence rate of cancer among infertile men was 1.7 times that of the general population, and when stratified by azoospermic status, men with azoospermia had substantially elevated risk of cancer (standardized incidence rate = 2.9). In contrast, men without azoospermia had an increased risk of 1.4 times that of men in the overall ...
I am suffering from obstructive azoospermia. Following is my biopsy and other reportsoutcome: (1) A SMALL CYST OF 8 # 5 M.M. IS SEEN AT PERIURETHRAL REGION(LEFT
Hi sir/madam, I have done two semen analysis & both turned out to nil sperm count i.e azoospermia. PUS cells : 4-5 / hpf Epithelial cells: 1 -2 /hpf PH - 8 Reaction: Alkaline I did my blood work and the Hormone levels are FS
Dr. Paul Turek discusses his case of the year which began with azoospermia & the removal of both testis (double orchidectomy), but ended with normal sperm & a pregnant couple.
dear Ayurvedicure. i am skhan from Denmark, i am 26 years old and i have been diagnosed Azoospermia there is no living or dead cells in my semen plzz tell me
Rs17431717 near SFRS9 and rs12046213 near SFRS4 were significantly associated with a decreased risk of NOA, whereas rs10849753 near SFRS9 and rs6103330 in SFRS6 were associated with an increased risk of NOA. Of the two SNPs in SFRS9, only rs17431717 remained significant after conditioning on another. Combined analysis of three promising SNPs (rs17431717, rs12046213, and rs6103330) showed that compared with individuals with "0-2" risk alleles, those carrying "3," "4," and "≥5" risk alleles had 1.22-, 1.38-, and 1.90-fold increased risk of NOA, respectively.. Conclusion(s): ...
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The use of clomid to induce spermatogenesis in non-obstructive azoospermia (Reproductive Medicine) @ Allan Chang Seminar Room, 1E O&G Department ...
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3-UTR of mRNAs and regulating their translation.
Picture source: CSP Networks To a couple undergoing interventions for infertility, being told that the husbands semen is devoid of sperm is incredibly devastating. All hopes of starting a family completely crumble and the feeling of hopelessness is quite overwhelming. Normally, sperm is produced in the testicles, then
Hey Folks, Thought I would weigh-in, I went to my GP who did a complete Blood Test, Bone Test etc... Since then we have found that I have a High HBA1C Result meaning I have diabetes which leads to an explination for the Low Testosterone - page 28
DAZ3 antibody (deleted in azoospermia 3) for ICC/IF, IHC-P, WB. Anti-DAZ3 pAb (GTX106859) is tested in Human samples. 100% Ab-Assurance.
Kestabilan bagi jentera buas ini dibantu dengan penggunaan set penyerap hentak boleh laras lengkap dari Cusco yang akan memastikan kedudukannya tidak begitu liar ketika sedang dipacu di atas jalan. Penggunaan brek dari Galant VRG serta brek asal dari Evo III yang dipasangkan dengan pelapik brek berketahanan tinggi pula membantu untuk memberhentikan jentera ini dalam apa jua situasi dengan selamat.. Ruang dalaman jentera ini telah disalin sepenuhnya dari peralatan Evo III. Kelihatan tempat duduk bucket Recaro SPG yang dipasang pada bahagian hadapan bagi memegang cekap kedudukan pemandunya ketika beraksi. Akhir sekali, rim Volk Racing TE37 bersaiz 16 inci dipasangkan serta dibaluti dengan tayar Yokohama berukuran 205/55R16 dipasangkan sekaligus menampilkan personaliti yang sangat hebat pada jentera ini.. Projek naik taraf jentera ini telah dilakukan oleh sebuah bengkel yang sangat terkenal dengan hasil kerja yang sangat hebat iaitu B Machine Development. Ternyata mereka sentiasa memberi ...
Percutaneous Epididymal Sperm Aspiration, Sperm Retrieval Techniques at Santati Fertility Center Mumbai and Thane, the Indias largest independent infertility Percutaneous Epididymal Sperm Aspiration treatment provider
Testicular Sperm Aspiration, Sperm Retrieval Techniques at Santati Fertility Center Mumbai and Thane, the Indias largest independent infertility Testicular Sperm Aspiration treatment provider
A varicocele is a dilatation of the veins of the pampiniform (venous) plexus in the spermatic cord in the male. It is a very common finding in infertile men being associated with 15% of men with primary infertility and 80% of men with secondary infertility. Though varicocele repair in infertility has always been a point of semantics, it has been proven that repair can improve pregnancy rates. Azoospermia due to testicular failure is classified as non obstructive Azoospermia (NOA) and the tteatment usually entails testicular sperm extraction(TESE) with ICSI. Though varicocelectomy can produce motile sperm in these patients the benefits remain unclear.. Various researchers have been studying the effects of Microsurgical varicocelectomy in NOA patients. Most findings concluded that if Azoospermia is not too long standing, then the effects of Varicocelectomy may produce motile sperm and also may reduce the need for a TESE during an ICSI procedure. It is important to note that none of these ...
To provide indicators for the likelihood of sperm retrieval in patients undergoing testicular sperm extraction is a major issue in the management of male infertility by TESE. The aim of our study was to determine the impact of different parameters, including testicular histopathology, on sperm retrieval in case of reoperation in patients undergoing testicular sperm extraction. We retrospectively analyzed 486 patients who underwent sperm extraction for intracytoplasmic sperm injection and testicular biopsy. Histology was classified into: normal spermatogenesis; hypospermatogenesis (reduction in the number of normal spermatogenetic cells); maturation arrest (absence of the later stages of spermatogenesis); and Sertoli cell only (absence of germ cells). Semen analysis and serum FSH, LH and testosterone were measured. Four hundred thirty patients had non obstructive azoospermia, 53 severe oligozoospermia and 3 necrozoospermia. There were 307 (63%) successful sperm retrieval. Higher testicular volume, lower
Azoospermia is a medical condition faced by men in which there is complete lack of sperm in semen resulting in a situation where a couple cannot conceive a child. It is a very frustratiing problem and can lead to other ailments like depression. There are many reasons which can cause azoospermia but it has no symptoms associated with it. A man can only find out if he is suffering from azoospermia when he cannot conceive a child and goes through a fertility test.. The good thing is that once it is ascertained that a person is suffering from no sperm count he can take help and overcome this problem. In this article we are going to discuss about how natural form of treatment can help in producing sperms and treating azoospermia.. It has been observed that this condition is mainly the result of hormonal imbalance in the body hence natural form of treatment can be of great help as they help in substituting the male hormones and bring them to normal levels. By doing this the natural medicine will ...
Azoospermia factor (AZF) refers to one of several proteins or their genes, which are coded from the AZF region on the human male Y chromosome. Deletions in this region are associated with inability to produce sperm. Subregions within the AZF region are AZFa (sometimes AZF1), AZFb and AZFc (together referred to as AZF2). AZF is the term used by the HUGO Gene Nomenclature Committee. AZF1 (Azoospermia Factor 1) gene is likely located in the euchromatic part of the long arm in Yq11.23. AZF1 is 792kb long and just distal to the centromere of the Y chromosome. AZF1 genes are involved in spermatogenesis in the testes. Originally, an AZFb and AZFc genes were identified and thought to be separate regions. They were later found to be overlapping and are now referred to as AZF2. AZFc is one of the most genetically dynamic regions in the human genome, possibly serving as counter against the genetic degeneracy associated with the lack of a partner chromosome during meiosis. However, such strategy comes has ...
Introduction: Y chromosomes are genetically highly variable due to frequent structural rearrangements. The variations may create a genetic background for the susceptibility to Y-related spermatogenic impairment, although few data have been accumulated about the possible correlation between the Y-chromosome haplotype and the predisposition of men to spermatogenic failure.. Objective: To investigate the possible association of Y-chromosome background with spermatogenic failure.. Methods: The distribution of 18 Y-chromosome haplogroups was compared between 414 infertile men with azoospermia or oligozoospermia and 262 normozoospermic men with or without AZFc deletions in a Han population of Southwest China.. Results: A significant population difference in Y-haplogroup distribution was found between the groups of normozoospermia and azoospemia or oligozoospermia, and between the patient groups with oligozoospermia and azoospermia without AZFc deletions. Interpopulation comparison of Y haplogroup ...
Azoospermia induced by Y chromosome microdeletions (AZF region) Test Cost INR 30000.00 Surat Pune Jaipur Lucknow Kanpur Nagpur Visakhapatnam Indore Thane Bhopal Patna Vadodara Ghaziabad Ludhiana Coimbatore Madurai Meerut Ranchi Allahabad Trivandrum Pondicherry Mysore Aligarh best offer discount price
Although structural autosomal abnormality that effaced on azoospermia/oligospermia patient not cleared on previous study we found numbers of this abnormality in cases with low sperm count. Pericentric inversion of the chromosome 9 usually considered as a normal variable feature of this chromosome in general population, but maybe appears to play some important roles in the infertility development. In the present study, 4 cases were found with pericentric inv(9), in which three patients with 46,XY,inv(9)(p12q13) and a 47,XXY,inv(9)(p11q13) as a variant of KS were oligospermic and azoospermic, respectively. A relationship between infertility and autosomal translocation has been observed among severely-oligo / azoospermic patients. In this study, reciprocal translocation t(16;20), rob(2;21), rob(13;15) and rob(15;21) were detected in oligospermic males, while t(Y;19) did in one azoospermic male. The exact mechanism by which chromosomal abnormality induces infertility is not fully understood. While ...
Several authors have examined the effectiveness of percutaneous procedures for sperm retrieval in OA. Sperm retrieval rates have been quoted at approximately 100% when percutaneous epididymal and testicular retrievals are combined (38-43) (Table 1). Glina et al. reported a series of 58 men with OA treated with ICSI who underwent percutaneous epididymal sperm retrievals (with rescue TESA whenever needed). The authors reported 100% recovery of motile sperm using these combined techniques. Successful repeated PESA was performed up to three times, with recovery of motile sperm in over 80% of the cases. Forty-three percent of PESA procedures yielded sufficient spermatozoa to allow cryopreservation (42). Esteves et al. reported a SRR of 97.9% among 142 men with OA. In these series, TESA as a rescue procedure after a failed PESA was performed in 17% of the cases. One-third of the retrievals yielded a sufficient number of spermatozoa for cryopreser-vation (32). Lin et al. analyzed 100 men with ...
The method of choice for sperm retrieval (SR) is based on the type of azoospermia, which can be obstructive or non-obstructive, and the attending surgeons preferences and experience. Obstructive azoospermia (OA) is associated with the inability to detect spermatozoa in the ejaculate and post-ejaculate urine after centrifugation due to the bilateral obstruction of the seminal ducts.. Hence in such cases Percutaneous Epididymal Sperm Aspiration is done. We have got successful results with PESA and we can keep the extra sample frozen for future use.. Testicular Sperm Extraction (TESE)- The extraction of the testicular tissue (Fig 12) for sperm search and isolation is done usually in PESA failed patients or proven obstructive azoospermia cases. For conventional TESE, a standard open surgical biopsy technique is used to remove the testicular tissue without the aid of optical magnification. This is a day care and minimally invasive procedure.. ...
Azoospermia is a reported side effect of androgen drugs and corticosteroids because they suppress the hypothalamus release of GnRH and therefore FSH. This causes azoospermia in males and amenorrhea in females. Compare with aspermia. ...
A new study has shown that a surgical technique called microdissection testicular sperm extraction (TESE) can effectively locate and extract viable sperm in more than one-third of adult male childhood cancer survivors who were previously considered sterile due to prior chemotherapy treatment.
Congenital bilateral absence of vas deferens (CBAVD)is diagnosed in 1.3 % of the men referred for infertility evaluation. Moreover, CBAVD accounts for 27% of the men with primary obstructive azoospermia. An almost equal number of men with other causes of surgically unreconstructable obstructive azoospermia are referred for evaluation.
A low sperm count, or in scientific terms oligospermia/ azoospermia, refers to a condition where the concentration of sperm in ejaculated semen is below normal or not existing. That begs the question - What is normal sperm concentration supposed to be? World Health Organization (WHO), acclaims that concentration of ,15 million sperm/ml is a low sperm count. If there appears to be no sperm in the sperm analysis it is called azoospermia.. ...
RESULTS. The prevalence of chromosomal anomalies and Y-microdeletions in the study population were 8.5% (25/295; 95% confidence interval, 5.6-12.3%) and 6.4% (19/295; 3.9-9.9%), respectively. The total prevalence of chromosomal anomalies and Y-microdeletions was 13.2% (39/295; 95% confidence interval, 9.6-17.6%) as five cases of non-obstructive azoospermia showed both Y structural alterations and AZFbc deletion. The corresponding figures for chromosomal anomalies in the groups with non-obstructive azoospermia, very severe oligospermia, and severe oligospermia were 21.1% (15/71; 95% confidence interval, 12.3-32.4%), 5.7% (9/158; 2.6-10.5%), and 1.5% (1/66; 0.0-8.2%). While for Ymicrodeletions they were 8.5% (6/71; 3.2-17.5%), 8.2% (13/158; 4.5-13.7%) and 0% (0/66; 0.0-4.4%), respectively. The respective overall prevalence rates for chromosomal anomalies and Y-microdeletions in these groups were: 22.5% (16/71; 13.5-34.0%), 13.9% (22/158; 8.9-20.3%), and 1.5% (1/66; 0.0-8.2 ...
This review offers recommendations for diagnosing and defining the etiology of azoospermia. Patients with severe oligospermia may be evaluated in a similar manner.
Non-obstructive coronary artery disease (CAD) is particularly common in women and associated with reduced quality of life and increased cardiovascular morbidity and mortality. The project will recruit patients with angina pectoris and non-obstructive CAD by CT- coronary angiography for further imaging with contrast stress echocardiography for diagnosis of myocardial ischemia. Better characterization of patients with symptomatic non-obstructive CAD due to myocardial ischemia will be done by vascular assessment by tonometry, biochemical and genetic markers as well as quality of life questionnaire. This interdisciplinary project is expected to add new knowledge to the impact of multimodality cardiac imaging in improving diagnosis in patients with symptomatic non-obstructive CAD ...
Recently insulin resistance (IR) has been recognized as the underlying pathogenesis of chronic anovulation, hyperandrogenism, and metabolic abnormalities associated with PCOD in women. IR could be the underlying pathogenesis of chronic hypospermatogenesis leading to oligospermia and azoospermia associated with other metabolic abnormalities in men. Metformin has proven as an effective medication for not only IR but several other aspects of the PCOD including reproductive abnormalities. Therefore, insulin sensitizers, particularly metformin can be introduced as a pharmaceutical option for unexplained oligozoospermia and azoospermia associated with insulin resistance ...
Male infertility accounts for 40% of fertility problems. A simple set of sperm tests from Genea can help identify if there are any issues.
When you express interest in a specific study, the information from your profile will be sent to the doctor conducting that study. If youre eligible to participate, you may be contacted by a nurse or study coordinator. If you select a health category rather than a specific study, doctors who have active studies in that area may contact you to ask if you would like to participate. In both cases, you will be contacted by the preferred method (email or phone) that you specified in your profile. ...
... for IVF or IUI is performed at Southern California Reproductive Center. The sperm retrieval used for male factor infertility uses MESA or TESE
Male infertility is a bane for many a childless couple. The most common affliction that a man presents with is oligozoospermia (reduced sperm concentration ) or Azoospermia ( complete absence of sperm ).
In these cohorts, eight known TSPYL1 SNPs were identified, none of which was significantly associated with male infertility. Two potentially disease-causing variants were detected in the infertile cohort: one man with azoospermia was found to be heterozygous for the novel TSPYL1 variant c.419C,G (p.Ser140Cys), and the rare substitution c.1098C,A (p.Phe366Leu) was identified in a man with OAT syndrome in the heterozygous state. Additionally, one fertile man was found to be heterozygous for the rare variant c.487G,A (p.Val163Ile). In silico analyses predicted a nonpathogenic effect for all amino acid exchanges, although protein features might be affected by p.Ser140Cys and p.Phe366Leu, respectively.. Conclusion(s): ...
List of causes of Abdomen sensitivity and Non-obstructive gastrointestinal causes of vomiting and regurgitation in childhood, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
From NCBI Gene:. This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein is thought to function as a splicing regulator during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]. From UniProt: ...
DAZ2 is a member of the DAZ family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). This RNA-binding protein is important for…
In case of azoospermia (absence of any living sperm cells in the ejaculate) it is sometimes possible to retrieve sperm through surgical methods MESA or TESE.
What exactly is surgical sperm retrieval? Heres our round-up the key techniques. These include PESA, TESE, TESA and MESA. Theyre not as scary as they sound.
Aspermia treatment. Accurate diagnosis of male infertility. Conservative and surgical treatment of azoospermia and aspermia. How to improve sperm quality.
Surgical sperm retrieval is a way of collecting sperm in men who have little or no sperm in their semen. Doctors can use this sperm in fertility treatments.
Antigen Background This monoclonal antibody recognizes both wild type and mutant forms of human p53 protein under denaturing and non-denaturing conditions. The epitope recognized by clone DO-7 can be destroyed by prolonged fixation in buffered formalin. The heat induced epitope retrieval technique may improve staining in some cases.. ...
The most adequate treatment option to cure oligospermia depends on the cause. We can choose between a natural, pharmacological or surgical treatment.
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Complete information for DAZL gene (Protein Coding), Deleted In Azoospermia Like, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for DAZL gene (Protein Coding), Deleted In Azoospermia Like, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Funnily enough, I found Max before I found Vee, when Hubby and I were looking for others out in infertility-world who were dealing with Azoospermia. Dynamo Dad postings eventually pointed me to his dear wife Vees blog and the rest is history. I hope that one day, Vees little Boo and our Petite will get to meet each other, but even if it doesnt happen, Vee and I will forever have an amazing friendship. I raised a glass for Max the other day, and I have been thinking about Vee and Boo all week. Thank you for directing your readers her way; I know it means the world to her!. ...
Azoospermic is a condition in which a certain portion of the male population suffers. There are three primary categories, which include 1) pretesticular, 2) testicular, and 3) post-testicular. Two forms are generally curable.
Male infertility could be due to various factors or disorders. To treat male infertility these factors are to be analysed and then successfully treated.Here are some options to treat male infertility.
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ABSTRACT with KEYWORDS: 47,XXY, XXY syndrome, fertility, intracytoplasmic sperm injection, Klinefelter syndrome, male, male infertility, microdissection testicular sperm extraction, non-mosaic Klinefelter syndrome, non-obstructive azoospermia, paternity, sperm count, sperm re- trieval, testicular sperm aspiration, testicular sperm extraction, testicular sperm retrieval, testosterone
One in every 500 men is born with an extra X chromosome, with a karyotype of 47, XXY rather than the typical 46, XY male karyotype. This is known as Klinefelter Syndrome and is the most common genetic variation which impacts a mans fertility. Men with pure Klinefelter Syndrome are nearly universally azoospermic with a sperm count of zero in the semen due to a lack of adequate sperm production in the testicles. Just nearly two decades ago these men were told they could not be fathers with their own sperm, but things have dramatically changed in our understanding since then.. The majority of men with Klinefelter Syndrome, approximately 70%, can have sperm retrieved through a highly meticulous microdissection testicular sperm extraction (microTESE) in the hands of highly skilled microsurgically trained reproductive urologists. Dr. Parviz Kavoussi performs microTESE regularly with excellent sperm retrieval rates. The embryologists from Westlake IVF join him in the operating room for this highly ...
TY - JOUR. T1 - A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia. AU - Zhao, Han. AU - Xu, Jianfeng. AU - Zhang, Haobo. AU - Sun, Jielin. AU - Sun, Yingpu. AU - Wang, Zhong. AU - Liu, Jiayin. AU - Ding, Qiang. AU - Lu, Shaoming. AU - Shi, Rong. AU - You, Li. AU - Qin, Yingying. AU - Zhao, Xiaoming. AU - Lin, Xiaoling. AU - Li, Xiao. AU - Feng, Junjie. AU - Wang, Li. AU - Trent, Jeffrey M.. AU - Xu, Chengyan. AU - Gao, Ying. AU - Zhang, Bo. AU - Gao, Xuan. AU - Hu, Jingmei. AU - Chen, Hong. AU - Li, Guangyu. AU - Zhao, Junzhao. AU - Zou, Shuhua. AU - Jiang, Hong. AU - Hao, Cuifang. AU - Zhao, Yueran. AU - Ma, Jinglong. AU - Zheng, S. Lilly. AU - Chen, Zi Jiang. PY - 2012/5/4. Y1 - 2012/5/4. N2 - A genome-wide association study of Han Chinese subjects was conducted to identify genetic susceptibility loci for nonobstructive azoospermia (NOA). In the discovery stage, 802 azoospermia cases and 1,863 controls were ...
Background: AZFc on human Y chromosome has been found to be functionally important in spermatogenesis. Complete AZFc deletion is one of the most frequent causes of male infertility, while roles of partial AZFc deletions (gr/gr deletion and b2/b3 deletion) in spermatogenesis are controversial. Methods: To further study the roles of partial AZFc deletions in spermatogenic impairment and the relationship between complete and partial AZFc deletions, we typed these deletions, did quantitative analysis of DAZ gene copies, and performed Y chromosome haplogrouping in seven pedigrees of complete AZFc deletion carriers, 296 infertile and 280 healthy men in Chinese. Results: Neither gr/gr deletion nor b2/b3 deletion was found to be associated with spermatogenic failure. In one pedigree, we observed that a complete AZFc deletion was derived from gr/gr deletion, suggesting that complete deletions of AZFc can be preceded with partial deletions. In addition, we identified a new gr/gr-deleted Y haplogroup Q1 ...
European Association of Urology GUIDELINES ON MALE INFERTILITY G.R. Dohle, W. Weidner, A. Jungwirth, G. Colpi, G. Papp, J. Pomerol, T.B. Hargreave UPDATE MARCH 2004 TABLE OF CONTENTS PAGE 1 INTRODUCTION 1.1 Definition 1.2 Epidemiology and aetiology 1.3 Prognostic factors 1.4 Recommendations 1.5 References 6 6 6 6 7 7 2 INVESTIGATIONS 2.1 Semen analysis 2.1.1 Frequency semen analyses 2.2 Advanced diagnostic spermatological tests 2.3 Recommendations 2.4 References 7 7 7 8 8 8 3 PRIMARY SPERMATOGENIC FAILURE 3.1 Definition 3.2 Aetiology 3.3 Testicular morphology 3.4 History and physical examination 3.5 Investigations 3.5.1 Semen analysis 3.5.2 Hormonal determinations 3.5.3 Combination obstructive/non-obstructive azoospermia 3.5.4 Sertoli cell-only syndrome (SCOS) 3.5.5 Testicular biopsy 3.6 Biopsy techniques 3.6.1 Open biopsy 3.6.2 Percutaneous testicular biopsy 3.6.3 Testicular fine-needle aspiration 3.7 Treatment 3.7.1 Predictive parameters for successful TESE 3.8 TESE techniques 3.8.1 ...
TY - CHAP. T1 - Klinefelter syndrome. T2 - Early treatment of the adolescent is not warranted. AU - Katz, Matthew J.. AU - Ramasamy, Ranjith. AU - Schlegel, Peter N.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Klinefelter syndrome (KS) is the most common sex chromosomal disorder in men, diagnosed 1 in 600 newborn males. Young boys with KS typically display various hormonal abnormalities and spermatogenic degeneration before the completion of puberty. There is controversy as to the optimal time to begin fertility treatment in KS patients. While early intervention has been proposed, treatment of KS adolescents is not warranted based on currently available data. Early intervention, including testosterone therapy and testicular biopsy can result in long-term adverse effects. Cryopreservation of spermatogonial stem cells during adolescence is of unknown benefit. Sperm retrieval rates in KS adults are better than retrieval rates from adolescents and comparable or better than rates seen in other men with ...
What is Surgical Sperm Retrieval?. This is a treatment option for men with Azoospermia (absence of sperm in the ejaculate) due to obstruction or poor production (non-obstructive).. Sperm can be collected directly from the epididymis where sperm are usually stored and matured. The sperm can be collected using a fine needle and syringe. This is known as (percutaneous epididymal sperm aspiration) or PESA. Sperm can also be retrieved from the testicles, a procedure known as (testicular sperm extraction) or TESE.. Surgical sperm retrieval is carried out by an experienced surgeon, usually a Consultant Uroandrologist, or a fertility specialist. The procedure needs to be timed to coincide with the female partners egg collection. If enough sperm is retrieved, it may be possible to freeze small amounts for use at a later stage. The sperm collected is then used to inject the eggs using ICSI.. ...
Vasoepididymostomy is considered the most technically challenging operation in male reproductive microsurgery.. The outcome of this procedure is highly dependent on the experience of the micro surgeon.. On physical examination fullness of epididymis in azoospermic patient is suggestive of epididymal obstruction.. With experienced microsurgeons post operative patency rate can be achieved in > 80% of patients.. Compared with vasovasostomy, the sperm concentration and sperm motility achievable with vasoepididymostomy tend to be lower, due to smaller size of the anastomosis.. Natural pregnancy rate around 30%. ...
Learn and compare which renowned fertility clinics offer Microdissection TESE (Testicular Sperm Extraction) in Pismo Beach, United States.
Question - No pain, discomfort or swelling, ultrasound detected Azoospermia, mild hydrocele, normal testosterone. Herbal treatment increase sperms and cure hydrocele?. Ask a Doctor about when and why Ultra sound is advised, Ask an Infertility Specialist
Dr. Stanton Honig is a nationally known expert on male fertility, sexual medicine and surgery and gender affirming surgery. In his large clinical urology practice, he focuses on providing compassionate, personalized care to men struggling with infertility,sexual problems and gender affirming surgery for male to female, in addition to general urology. This involves working with couples that are having trouble conceiving because of male reproductive issues, such as no sperm in the ejaculate, low sperm counts or blockage of the vas deferens, the tiny tubes that deliver sperm. Dr. Honig has been at the forefront of many groundbreaking techniques in urology, including sperm retrieval techniques, medical and surgical treatment of erectile dysfunction, treatment of peyronies disease (curvature of the penis) and unique treatments for low testosterone, vasectomy and testis implants. He has started the first gender affirming surgery program in New England in 2016.. To provide coordinated care for ...
At Cornell University Weill Medical College. Provides the most updated information and success rates for vasectomy reversal, no-scalpel vasectomy, varicocelectomy, testicular and epididymal sperm retrieval; treatment of obstructive and non-obstructive azoospermia for male infertility. ...
Approximately 1% of all men in the general population suffer from azoospermia, and Azoospermia treatment is available at Chandigarh, Punjab, Patiala, India.
      Microfluidics is the precise control and manipulation of small-volume fluids in order to observe behavior of the fluid itself or its contents. One recently explored application of microfluidics is gamete sorting and selection for use in In Vitro Fertilization (IVF). Previous applications of microfluidic techniques for sperm manipulation involved healthy sperm cells swimming to a collection area. However, these techniques cannot be applied to samples containing healthy non-motile sperm cells, such as for patients with non-obstructive azoospermia. The microfluidic device used in this study gives the opportunity for the separation and organization for non-motile sperm using an innovative spiral-shape, and gives possible current treatments.           The overall goal of this exploration is to design a spiral channel device in order to sort non-motile sperm cells. The objective of this study is to determine the effects that the device has on cell motility and ...
Sperm retrieval refers to any procedure that is used to obtain sperm for fertility purposes. In general, sperm retrieval is performed when there is either no sperm present in the semen or if men are unable to ejaculate. In almost all cases, sperm retrieval must be utilized in combination with in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) for reasonable pregnancy rates to be obtained.
Although only a fraction of men with infertility have a demonstrable distal ductal abnormality, it is crucial to identify these patients to determine if the defect is correctable and to avoid unnecessary testing in men with non-correctable abnormalities who should proceed to assisted reproduction. In the absence of retrograde ejaculation, neurologic disorders and diabetes, men with azoospermia and low ejaculate volumes (1.5 mL or less) should be examined for congenital anomalies or obstructive defects of the distal genital tract. Kuligowska and Fenlon evaluated the effectiveness of transrectal ultrasound in infertile men to evaluate its role in patient care.. Male patients with infertility, low ejaculatory volumes and azoospermia were evaluated. On the basis of the location and nature of the transrectal ultrasound findings, the men were selected for either surgery or radiologic intervention. Of the 276 men who underwent trans-rectal ultrasound examination, 70 (25.4 percent) had no anatomic ...
Collection of testicular sperm directly from the testes allows us to help men with azoospermia to have a baby with their own sperm ! This is called testicular sperm extraction with ICSI ( TESE-ICSI ). Its easy to find sperm in men with obstructive azospermia, because their testes produce sperm normally
Urgency. Changes in the right ventricle (RV) under hypertrophic cardiomyopathy (HCVP) are understudied. Aim. To study the condition of RV in this disease. Materials and methods. 86 patients with different forms and variants of HCVP including 69 patients with non-obstructive form of the disease (HNCVP) were evaluated using echoCG. The RV condition was studied by measuring the cavity dimensions and the systolic and diastolic thickness of the anterior wall with estimation of additional parameters reflecting the local diastolic and systolic function. Results. Predominant hypertrophy of the RV anterior wall was found in HCVP including the non-obstructive form. These changes were observed in almost 50% of patients. Anterior wall hypertrophy was associated with disorders of the wall diastolic function. The RV changes were detected primarily in the presence of more advanced and pronounced LV hypertrophy, especially in the apical region ...
34-year old man with complete masculinization and a history of several years of infertility was referred to us for genetic reviewing. His semen analysis showed azoospermia. Conventional chromosomal analysis indicates a 46,XX karyotype, molecular analyses excluded the presence of SRY (the sex-determining region of the Y chromosome) gene. This case is one of the rare cases reported in the literature in whom testicular differentiation and complete virilization were found in a 46,XX chromosomal constitution, with the absence of SRY gene. This finding suggests that other genes downstream from SRY play an important role in sex determination. Through reporting this rare case and reviewing previous literatures, the aim of this report is to highlight the value of genetically screening all males with azoospermia who present for evaluation of infertility, since the phenotype does not always correlate with the genotype ...
It can be diagnosed before or immediately after a child is born. In other cases, Klinefelter Syndrome is identified during childhood when learning or behavioural difficulties develop, or around the time of puberty when expected physical changes are delayed or dont happen.. Because the symptoms arent always obvious, an adult might not be diagnosed until they seek medical help for infertility, a loss of sex drive, or a bone fracture. The majority of Klinefelter cases are diagnosed in adulthood.. We think that as many as 75% of men with Klinefelter Syndrome are never diagnosed, and remain untreated for life, possibly because doctors dont routinely check the size of testicles.. ...
In terms of the childs education, XXYs with Klinefelter Syndrome are typically well behaved in the classroom and are eager to please the teacher. However, if they are presented with material that they find difficult, they tend to withdraw. If it goes unnoticed by the teacher, the child may fall behind in the curriculum and may need to be held back a grade. Therefore, it is important, for the success of the child, to be in a small classroom where he can receive sufficient individual attention from the teacher. The childs chances of success are even greater if the parents and school cooperate to form an individualized education plan and provide related services if necessary ...
If no sperm is retrieved from the epididymis or where a non-obstructive problem, or a problem with the sperm-making process is diagnosed, then a biopsy of one or both testes may be necessary. In this case a small cut is made in the scrotal skin and in the surface of the testis so that a small amount of tissue can be removed. A small dissolving stitch will allow easy healing of these wounds. In this case a small portion of the tissue may be sent for laboratory assessment of its structure and the sperm production process. The rest will be retained for sperm retrieval. Although it is less likely, mature testicular sperm can sometimes be frozen for future use.. ...
Surgical Sperm Retrieval Treatment in Delhi, India is easily performed by many known hospitals. Get in touch with Viezec to know about such hospital in Delhi, India.
My DH is azoospermic too. And I am for the most part annovulatory (although since we found out my husband i azoospermic, I have started getting periods again, go figure). They believe he has congenital absence of the vas defrens, and he will most likely get his sperm retrieved. Hopefully sperm is there, but so far they think it is. We will do IVF/ICSI which will be scheduled as soon as he sees his new urologist that works with our ferility center Nov 7th. Which seems like lightyears away for me. I wish you the best of luck and I hope it all works out for you. Does your DH also have CAVD ...
This trial will investigate efficacy, safety, tolerability and dose ranging of MYK-461 in patients with symptomatic non-obstructive hypertrophic cardiomyopathy
Call me a nerd, but I have to admit that I am pretty excited about metabolomic technology. Uh, what? Metabolomics is the study of the chemical fingerprints that cells leave behind. It does not look at genes, DNA, RNA or proteins, but is a peek into the products or metabolites that result from all this genetic orchestration. It is a "physiological snapshot" of a living cell.. This past week, we published a study that applies metabolomics to male infertility. If you have been reading this column, you are well aware of my interest in helping sterile men become fathers. Over the last decade, it has become clear that many men with azoospermia (no ejaculated sperm) may have small pockets of sperm in the testicle. The question is how to safely find that sperm without causing undo harm to the testicle. Current methods for evaluating whether sperm are present include somewhat invasive techniques such as testicular biopsy and microdissection and less invasive ones such as FNA Sperm Mapping that I invented ...
check many that the read or yourself stay articulating preliminary, hazardous books, ahead than level that is found necessarily by people, and actually on. get consistent that you are your read Klinefelter Syndrome and the sense of your experiences. These should return cardiogenic and Typical from the read Klinefelter.
Azoospermia is one of the most severe forms of male factor infertility. It is a condition in which a man has no sperm in his ejaculate. In order to tr.... Rawalpindi, Pakistan ...
Azoospermia is one of the most severe forms of male factor infertility. It is a condition in which a man has no sperm in his ejaculate. In order to tr.... Rawalpindi, Pakistan ...
I recently received a heartbreaking email from a young man. My medical history is as follows. I have been treated for testicular cancer in 2003 and one of my testicles is removed with a surgery. Before and after the surgery I have undergone 4 cycles each of chemotherapy. Every 6 months I get the blood tests done and everything seems to be normal for me. Last year April I have undergone testicular biopsy and it resulted in azoospermia. Last month I got the FSH blood tests done and it came out as 23.51.I have consulted many doctors and as my FSH is high one of the doctor has referred us to sperm donor program. Is this my only option ? Is there any way I can have a baby with my own sperm ?. Unfortunately, this man now has complete testicular failure; and his sperm production has been wiped out as a result of the cancer chemotherapy. Ideally, his sperm should have been banked ( cryopreserved in a sperm bank) prior to his starting chemotherapy. Unfortunately, this was not done, as a result of which ...
There are many things which can lead to various sex problems, some of which are difficult to pinpoint. Klinefelter syndrome is a chromosomal disorder that can cause problems in the bedroom.
As this eMedTV page explains, children with Klinefelter syndrome are similar to other children, except they usually have difficulties in language acquisition and development. This page provides tips for parents of children with this condition.
Different babies develop at different rates. Sitting up and standing come at different times to babies and it doesnt necessarily mean that there is a problem. Usually, even those that are a bit slower than the others will catch up with the rest at some point.. Despite this, however, slower than usual developing can be a sign of Klinefelter syndrome. It might not be noticeable to begin with because babies do develop at different rates. In addition to sitting and standing, it can also cause babies to develop slower than others when it comes to speech. If you do notice a baby is developing slower than they should do, you should arrange to get it checked out.. Advertisement. ...
Assisted Reproduction Techniques gives a wide-ranging practical guide to all those wishing to support couples who cannot conceive naturally.
... - - you start to like the smell of vinyl being carved- you find stamp shreds everywhere!- you rescue used, unloved erasers
I have a problem of PCOS and my husband has a problem of azoospermia and i have undergone IVF procedure for about 3 times,one time i got pregnant but than miscarriage in my 6th week . So is there any better chance that i will conceive agai
In this population‐based study, we found that ≈47% of patients with nonobstructive CAD were treated with OMT within 1 year; however, there was a 2‐fold variation in the proportion of OMT use between institutions. Almost all of this between‐hospital variation was associated with differences in baseline medication use. The variation in OMT had clinical consequences because we found that receiving OMT after angiography was associated with a reduction in all‐cause hospitalization.. There are clear guidelines for medical management of stable obstructive CAD, which include aspirin, ACE‐I, or ARB in appropriate patients, an anti‐ischemic agent, and statins.14 Despite these guidelines for management of stable obstructive CAD, previous work from our group and others has demonstrated that OMT is underused in this patient population.1, 2, 14, 16 In contrast, there are no definitive guidelines for medical management of nonobstructive CAD, and there is substantial uncertainty as to what ...
Over 50 articles! Chemicals, translations and the arts.... is there such a thing as a wikimath? Anyway thanks from me and the wiki. Oh and can I tell you that the 100 medal is really nice colour of gold ... Victuallers (talk) 15:27, 1 March 2009 (UTC ...
FOXC1 Azoospermia due to perturbations of meiosis; 270960; SYCP3 Azoospermia; 415000; USP9Y Baller-Gerold syndrome; 218600; ...
AZF1 (azoospermia factor 1). *BPY2 (basic protein on the Y chromosome). *DAZ1 (deleted in azoospermia) ...
Azoospermia D.Graham, Sam; James Francis Glenn; Thomas E. Keane (2004). Glenn's urologic surgery. Lippincott Williams & Wilkins ... Seminal plasma proteins TEX101 and ECM1 were recently proposed for the differential diagnosis of azoospermia forms and subtypes ... "Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma". Science ... The testicular sperm extraction process is recommended to men who cannot produce sperm by ejaculation due to azoospermia, such ...
The reduced fertility (azoospermia) is due to functional obstruction of sperm transport down the genital tract at the ... Obstructive azoospermia and chronic sinopulmonary infections". N. Engl. J. Med. 310 (1): 3-9. doi:10.1056/NEJM198401053100102. ... Young's syndrome, also known as azoospermia sinopulmonary infections, sinusitis-infertility syndrome and Barry-Perkins-Young ...
It could potentially treat azoospermia. In 2012, oogonial stem cells were isolated from adult mouse and human ovaries and ...
In men with no sperm count (azoospermia), it soon became clear that sperm could be found in the testes and used with ICSI, but ... Post-chemotherapy ejaculatory azoospermia: Fatherhood with sperm from testis tissue using intracytoplasmic sperm injection. J ... The Reversibility of Anabolic-Induced Azoospermia. Journal of Urology, 153 (5): 1628-1630, 1995 , Turek P.J. Boxers and ... extraction and intracytoplasmic sperm injection guided by prior fine needle aspiration mapping in nonobstructive azoospermia. ...
Obstructive azoospermia and chronic sinopulmonary infections". NEJM. 310 (1): 3-9. doi:10.1056/NEJM198401053100102. PMID ...
Svetec DA, Waguespack RL, Sabanegh ES (1998). "Intermittent azoospermia associated with epididymal sarcoidosis". Fertil Steril ...
Deleted in azoospermia protein 2 is a protein that in humans is encoded by the DAZ2 gene. This gene is a member of the DAZ gene ... "Entrez Gene: DAZ2 deleted in azoospermia 2". Foresta C, Ferlin A, Moro E, et al. (2002). "[Microdeletion of chromosome Y in ... 1998). "DAZ (Deleted in AZoospermia) genes encode proteins located in human late spermatids and in sperm tails". Hum. Reprod. ... family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ ...
Deleted in azoospermia 1, also known as DAZ1, is a protein which in humans is encoded by the DAZ1 gene. This gene is a member ... Menke DB, Mutter GL, Page DC (Jan 1997). "Expression of DAZ, an azoospermia factor candidate, in human spermatogonia". American ... DAZ1 deleted in azoospermia 1". Reijo R, Lee TY, Salo P, Alagappan R, Brown LG, Rosenberg M, Rozen S, Jaffe T, Straus D, ... of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to ...
Deleted in azoospermia protein 3 is a protein that in humans is encoded by the DAZ3 gene. This gene is a member of the DAZ gene ... "Entrez Gene: DAZ3 deleted in azoospermia 3". Foresta C, Ferlin A, Moro E, et al. (2002). "[Microdeletion of chromosome Y in ... family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ ...
Patients suffering from nonobstructive azoospermia or oligozoospermia show microdeletions in the long arm of the Y chromosome ... "Mutational screening of the NR5A1 in azoospermia". Andrologia. 47 (4): 395-401. doi:10.1111/and.12274. ...
Deleted in azoospermia-like is a protein that in humans is encoded by the DAZL gene. The DAZ (Deleted in AZoospermia) gene ... "Entrez Gene: DAZL deleted in azoospermia-like". Ruggiu M, Cooke HJ (Jul 2000). "In vivo and in vitro analysis of ...
In addition, if an obstruction of the vasa deferentia is the cause for the azoospermia, the concentration of fructose in the ... 50% of cases of unexplained low-volume azoospermia MRI and TRUS do not reveal any pathological findings, because it is ... A microscopic semen analysis will reveal aspermia/azoospermia. In contrast, if both vasa deferentia are obstructed (which may ... affected men will demonstrate male infertility due to aspermia/azoospermia. They will suffer from a very low volume of semen ...
Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ (November 2003). "Azoospermia in patients ... "SYCP3 mutations are uncommon in patients with azoospermia". Fertility and Sterility. 84 (4): 1019-20. doi:10.1016/j.fertnstert. ... messenger ribonucleic acid in 110 patients with nonobstructive azoospermia". Fertility and Sterility. 86 (2): 325-31. doi: ...
Shafik, Ahmed (1992). "Contraceptive efficacy of polyester-induced azoospermia in normal men". Contraception. 45 (5): 439-51. ...
"Contraceptive efficacy of testosterone-induced azoospermia in normal men. World Health Organization Task Force on methods for ...
"Altered microRNA expression in patients with non-obstructive azoospermia". Reproductive Biology and Endocrinology. 7: 13. doi: ...
Injection of medical polyurethane (MPU) to form a plug in the vas deferens resulted in azoospermia in 96% of men, though these ... Vasalgel was successful in achieving azoospermia in rabbits within 36 days of injection, as well as returned vas deferens ... This chemical combination resulted in a 96% azoospermia and a 99% pregnancy prevention eight years follow injection in humans. ... Waller, D; Bolick, D; Lissner, E; Premanandan, C; Gamerman, G (2016). "Azoospermia in rabbits following an intravas injection ...
Rajmil O, Fernández M, Rojas-Cruz C, Sevilla C, Musquera M, Ruiz-Castañe E (2007). "Azoospermia should not be given as the ... Aspermia: absence of semen Azoospermia: absence of sperm Hypospermia: low semen volume Hyperspermia: high semen volume ... volume of less than 2 mL in the setting of infertility and absent sperm should prompt an evaluation for obstructive azoospermia ...
In men with obstructive azoospermia, sperm is found in all sites and in all locations on the FNA map. However, in men with ... Post-chemotherapy ejaculatory azoospermia: Fatherhood with sperm from testis tissue using intracytoplasmic sperm injection. J ... In fact, the current clinical challenges are: (1) to determine which infertile men with azoospermia harbor sperm for IVF-ICSI ... Verma AK, Basu D, Jayaram G. Testicular cytology in azoospermia. Diag Cytopathol 1993;9:37-42. Batra VV, Khadgawat R, Agarwal A ...
TRUS plays a key role in assessing azoospermia caused by obstruction, and detecting distal CBAVD or anomalies related to ... ISBN 978-1-60761-193-6. Pasqualotto FF, Fonseca GP, Pasqualotto EB (2008). "Azoospermia after treatment with clomiphene citrate ... reduced seminal volume Azoospermia - absence of sperm cells in semen Teratospermia - increase in sperm with abnormal morphology ...
This condition is called nonobstructive or secretory azoospermia, as opposed to obstructive azoospermia, in which complete ... This technique can be used to enable genetic fatherhood to some men who have no spermatozoa in the ejaculate (azoospermia) and ... It can also be used in Azoospermia, "Valious spermatozoa" (from Fertility Preservation after cancer, or because of a ... In cases of nonobstructive (secretory) azoospermia, on the other hand, testicular sperm production is blocked at different ...
The use of euflavine does however, tend to decrease time (or, number of) ejaculations to azoospermia vs. the water irrigation ... Usually two semen analyses at three and four months are necessary to confirm azoospermia. The British Andrological Society has ... After a vasectomy, contraceptive precautions must be continued until azoospermia is confirmed. ... recommended that a single semen analysis confirming azoospermia after sixteen weeks is sufficient.[42] ...
Azoospermia due to testicular failure is classified as non obstructive Azoospermia (NOA) and the tteatment usually entails ... Varicocele Repair in Azoospermia. A varicocele is a dilatation of the veins of the pampiniform (venous) plexus in the spermatic ... Researchers many a time have said that men with Azoospermia may exhibit intermittent sperm production and may not be related to ... Most findings concluded that if Azoospermia is not too long standing, then the effects of Varicocelectomy may produce motile ...
However, azoospermia is an even bigger hurdle. Thus, we will spend a lot of time on this subject, since there is now good ... Silber S. (2018) Azoospermia. In: Fundamentals of Male Infertility. Springer, Cham. * First Online 01 August 2018 ... Rosenlund B, Kvist V, Ploen L et al (1998) A comparison between open and percutaneous needle biopsies in men with azoospermia. ... treatment of azoospermia with sperm retrieval and intracytoplasmic sperm injection. Hum Reprod 12:2693-2700CrossRefPubMedGoogle ...
... ANSWER Damage to testicles can keep men from making sperm normally. It can ...
Pretesticular azoospermia is seen in about 2% of azoospermia. Pretesticular azoospermia is a kind of non-obstructive ... Testicular azoospermia is a kind of non-obstructive azoospermia. Generally, men with unexplained hypergonadotropic azoospermia ... Many conditions listed may also cause various degrees of oligospermia rather than azoospermia. Pretesticular azoospermia is ... Pre- and post-testicular azoospermia are frequently correctible, while testicular azoospermia is usually permanent. In the ...
Azoospermia is the total absence of spermatozoa in the ejaculate. It is found in 10-15% of male infertility cases and is caused ... Obstructive azoospermia is less frequent and arises in 15-20% of men with azoospermia. Most causes of male infertility are ... Azoospermia is the total absence of spermatozoa in the ejaculate. It is found in 10-15% of male infertility cases and is caused ... Ejaculatory Duct Testicular Sperm Sperm Retrieval Obstructive Azoospermia Microsurgical Reconstruction These keywords were ...
Treatments and Tools for azoospermia. Find azoospermia information, treatments for azoospermia and azoospermia symptoms. ... azoospermia - MedHelps azoospermia Center for Information, Symptoms, Resources, ...
Azoospermia is a description of the finding of no identifiable sperm in a semen sample submitted during a fertility workup. ... The doctor said that I have azoospermia, and that well need to do more tests to figure out why. What is azoospermia and what ... What is azoospermia? As part of our treatment by a fertility specialist, I had to give a semen sample for examination. ... Azoospermia is a description of the finding of no identifiable sperm in a semen sample submitted during a fertility workup. ...
AZF1 (Azoospermia Factor 1) gene is likely located in the euchromatic part of the long arm in Yq11.23. AZF1 is 792kb long and ... Azoospermia factor (AZF) refers to one of several proteins or their genes, which are coded from the AZF region on the human ... It may cause azoospermia (not having any measurable level of sperm in semen). Deletions in the USP9Y gene, which is located ... USP9Y GeneReviews/NIH/NCBI/UW entry on Y Chromosome Infertility or Azoospermia Repping S, Skaletsky H, Lange J, Silber S, Van ...
If your azoospermia is not a genetic problem, doing the following can help lessen the chance of azoospermia:. *Avoid activities ... How can azoospermia be prevented?. There is no known way to prevent the genetic problems that cause azoospermia. ... Cocuzza M, Alvarenga C, Pagani R. The epidemiology and etiology of azoospermia. Clinics (Sao Paulo) 2014 Feb; 68(suppl 1):15-26 ...
48,XXYY syndrome; Azoospermie secrétoire; Biopsie testiculaire; Klinefelter syndrome; Non obstructive azoospermia; Syndrome 48, ... Usually considered as a variant of Klinefelter syndrome because of shared features (azoospermia, tall stature, ... 48,XXYY men with azoospermia: how to manage infertility?].. [Article in French] ...
deleted in azoospermia like. See related. Ensembl:ENSSSCG00000030671 Gene type. protein coding. RefSeq status. MODEL. Organism ... Deleted in azoospermia-like enhances in vitro derived porcine germ cell formation and meiosis. Park BW, et al. Stem Cells Dev, ... XM_003358321.3 → XP_003358369.1 deleted in azoospermia-like. UniProtKB/TrEMBL. A0A1B2TT46 Related. ENSSSCP00000026152.2, ... Molecular characterization and SNPs analysis of the porcine Deleted in AZoospermia Like (pDAZL) gene. Zhang YH, et al. Anim ...
How is azoospermia diagnosed?. Azoospermia is diagnosed when, on two separate occasions, no sperm cells can be found in samples ... How is azoospermia treated?. Genetic testing and counseling are often an important part of understanding and treating ... Men with non-obstructive azoospermia should receive genetic analysis before their sperm are used to perform any type of ... In cases of obstructive azoospermia, reconstruction or reconnection of obstructed or disconnected ducts can be performed. ...
... is the name given to the condition in which there are no sperm in the semen. The semen may look normal, but the ... and a blood test for FSH are useful tools for determining if you have obstructive azoospermia or non-obstructive azoospermia. ... Azoospermia is the name given to the condition in which there are no sperm in the semen. The semen looks normal, and the ... Azoospermia , as the name suggests , refers to the condition in which there are no sperm in the semen. This diagnosis can come ...
Azoospermia has two forms: *obstructive azoospermia, where sperm are created, but cannot be mixed with the rest of the ... congenital azoospermia, where azoospermia is a manifestation of cystic fibrosis due to agenesis of vas deferens. ... Orchitis · Hydrocele testis · Testicular torsion · Male infertility (Azoospermia, Oligospermia). Epididymis. Epididymitis · ... Azoospermia is the medical condition of a male not having any measurable level of sperm in his semen. It is associated with ...
Azoospermia has two forms: *obstructive azoospermia, where sperm are created, but cannot be mixed with the rest of the ... congenital azoospermia, where azoospermia is a manifestation of cystic fibrosis due to agenesis of vas deferens. ... Orchitis · Hydrocele testis · Testicular torsion · Male infertility (Azoospermia, Oligospermia). Epididymis. Epididymitis · ... Azoospermia. Revision as of 22:40, 8 August 2012 by WikiBot. (talk , contribs) (Bot: Automated text replacement (-{{SIB ...
Insulin Resistance in Idiopathic Oligospermia and Azoospermia. The safety and scientific validity of this study is the ... Azoospermia. Oligospermia. Hyperinsulinism. Glucose Metabolism Disorders. Metabolic Diseases. Infertility, Male. Infertility. ... unexplained oligospermia and azoospermia. Blood samples will be taken for hormonal and blood lipids analysis. ... Insulin Resistance : a New Diagnosis of the Pathogenesis of Idiopathic Oligozoospermia and Non Obstructive Azoospermia. ...
Deleted in azoospermia-likeAdd BLAST. 295. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ- ... sp,Q92904,DAZL_HUMAN Deleted in azoospermia-like OS=Homo sapiens OX=9606 GN=DAZL PE=1 SV=1 ... "Association of a single-nucleotide polymorphism of the deleted-in-azoospermia-like gene with susceptibility to spermatogenic ...
Primary Ovarian Insufficiency and Azoospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation.. Al-Agha AE1, Ahmed IA1, ... A brother had azoospermia.. Intervention: DNA was subjected to whole genome sequencing. Shared regions of homozygosity were ... in females but isolated azoospermia with normal pubertal development in males. The findings also suggest that the N-terminal ...
Azoospermia may be caused by a defect in spermatogenesis or by a physical obstruction that hinders the sperm to be mixed with ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Azoospermia&oldid=95089" ...
DMC1 mutation that causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome ...
Cluster: Deleted in azoospermia protein 4. 5. Q86SG3-2. Q9NR90. A0A0A0MSS9. I3L0B6. E7ENA6. Q9NR90-2. E7ERQ6. Homo sapiens ( ... Cluster: Deleted in azoospermia protein 1. 22. Q86SG3-2. Q9NR90. I3L0B6. A0A0A0MSS9. E7ENA6. Q9NR90-2. E7ERQ6. A0A087X2D7. ... Deleted in azoospermia protein 4Add BLAST. 579. Proteomic databases. PaxDb, a database of protein abundance averages across all ... "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ- ...
Hello everyone, Im Laura (27) and Nathan (29) we have just started TTC. My DH gets on here more then me, since he thought there was a problem on his end. This was confirmed yesterday when he got the results from the semen sample. He - page 15
PINA-NETO, J.M. et al. Somatic cytogenetic and azoospermia factor gene microdeletion studies in infertile men. Braz J Med Biol ... azoospermia factor genes, AZF) in infertile males who seek assisted reproduction. These studies are very important because the ...
I saw there was another thread on azoospermia, but it seems nobody is using it any more. I need some advice on what we should ... hi everyone , we have been working with an azoospermia diagnosis for a few years now .. I know all too well how devastating it ...
Hey Folks, Thought I would weigh-in, I went to my GP who did a complete Blood Test, Bone Test etc... Since then we have found that I have a High HBA1C Result meaning I have diabetes which leads to an explination for the Low Testosterone - page 28
  • Silber SJ, Van Steirteghem A, Nagy Z et al (1996) Normal pregnancies resulting from testicular sperm extraction and intracytoplasmic sperm injection for azoospermia due to maturation arrest. (springer.com)
  • A Cochrane review found insufficient evidence to recommend any specific surgical sperm retrieval technique for men with azoospermia undergoing intracytoplasmic sperm injection (ICSI). (wikipedia.org)
  • AZF1 (Azoospermia Factor 1) gene is likely located in the euchromatic part of the long arm in Yq11.23. (wikipedia.org)
  • An epigenetic mechanism regulates germ cell-specific expression of the porcine Deleted in Azoospermia-Like (DAZL) gene. (nih.gov)
  • Molecular characterization and SNPs analysis of the porcine Deleted in AZoospermia Like (pDAZL) gene. (nih.gov)
  • Title: Midkine promotes proliferation of primordial germ cells by inhibiting the expression of the deleted in azoospermia-like gene. (nih.gov)
  • The objective of the present study is to investigate the association between SEPT12 gene variation and the risk of azoospermia. (alliedacademies.org)
  • This finding suggests that G5508A variant in the SEPT12 gene may associate with the increased susceptibility to azoospermia. (alliedacademies.org)
  • Screening for deletions of the Y chromosome involving the DAZ Deleted in Azoospermia gene in azoospermia and severe oligozoospermias. (filmashqip.xyz)
  • This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). (nih.gov)
  • This study suggests a lack of association of SIN3A gene sequence variants with azoospermia caused by SCOS in humans. (cdc.gov)
  • The poly(A) polymerase beta gene may not be associated with azoospermia caused by Sertoli-cell-only syndrome in Japanese patients by comparing patients and normal controls. (cdc.gov)
  • Deleted in azoospermia protein 2 is a protein that in humans is encoded by the DAZ2 gene. (wikipedia.org)
  • Deleted in azoospermia 1, also known as DAZ1, is a protein which in humans is encoded by the DAZ1 gene. (wikipedia.org)
  • The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. (wikipedia.org)
  • The USP9Y gene is found on the azoospermia factor (AZF) region on the Y chromosome. (wikipedia.org)
  • Loss of this gene function results in the absence of sperm in semen (azoospermia). (wikipedia.org)
  • The DAZ1 (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. (wikipedia.org)
  • Azoospermia factor (AZF) refers to one of several proteins or their genes, which are coded from the AZF region on the human male Y chromosome. (wikipedia.org)
  • The most common chromosomal problem causing azoospermia in men is a situation where there is an extra X chromosome. (iaswellnesscentre.ng)
  • When one or more of the genes on this chromosome that is responsible for sperm production are deleted, it can result in azoospermia. (iaswellnesscentre.ng)
  • There is a particular region of the Y chromosome called the azoospermia determining factor and there are 3 separate mutations that can be found in this region that can significantly impact sperm production. (mensfertilityaustin.com)
  • To investigate the possibility of applying multiplex ligation-dependent probe amplification (MLPA) to the detection of azoospermia factor (AZF) microdeletion on the Y chromosome in infertile men with azoospermia or severe oligozoospermia. (bvsalud.org)
  • A substantial subset of men with this uncommon syndrome have microdeletions in the Yq11 region of the Y chromosome, an area known as the AZF (azoospermia factor) region. (wikipedia.org)
  • Analysing the semen analysis report carefully can often provide clues as to the reason for the azoospermia. (drmalpani.com)
  • I have been diagnosed with azoospermia after 2 negative semen analysis. (bubhub.com.au)
  • Hi sir/madam, I have done two semen analysis & both turned out to nil sperm count i.e azoospermia. (askthedoctor.com)
  • In addition to a medical history analysis and a quick and painless genital check-up, azoospermia can be diagnosed through a simple spermiogram (or semen analysis). (ingenes.com)
  • Azoospermia refers to a condition when a semen analysis shows virtually no sperm count. (mazemenshealth.com)
  • A microscopic semen analysis will reveal aspermia/azoospermia. (wikipedia.org)
  • In contrast, if both vasa deferentia are obstructed (which may be the result of intended sterilization), a semen analysis will also reveal aspermia/azoospermia, but an almost normal volume of the semen, since the efflux of the seminal vesicles is not hindered. (wikipedia.org)
  • Pretesticular' azoospermia occurs when normal reproductive organs are not properly stimulated due to imbalanced hormone levels. (zocdoc.com)
  • The PSMC3IP mutation provides additional evidence that mutations in meiotic homologous recombination and DNA repair genes result in distinct female and male reproductive phenotypes, including delayed puberty and primary amenorrhea caused by POI (XX gonadal dysgenesis) in females but isolated azoospermia with normal pubertal development in males. (nih.gov)
  • To understand the causes of and treatments for Azoospermia, we must first review how the male reproductive organs work. (malereproduction.com)
  • Many men with azoospermia have normal semen volumes but do not realize that there is no sperm in their fluid," says Marc Goldstein, M.D., the chief surgeon in the department of men reproductive medicine at New York Presbyterian Hospital, Weill Cornell Medical Center in New York City. (breastfeeding24.com)
  • congenital azoospermia , where azoospermia is a manifestation of cystic fibrosis due to agenesis of vas deferens . (wikidoc.org)
  • The scar tissue created is not always compact and successful in occluding the vas deferens, which results in the 4% azoospermia failure rate. (wikipedia.org)
  • Injection of medical polyurethane (MPU) to form a plug in the vas deferens resulted in azoospermia in 96% of men, though these result were seen 24 months after injection. (wikipedia.org)
  • Another example of treatable secretory azoospermia is when the cause are hormonal imbalances. (invitra.com)
  • Cancer patients who need to undergo radiation and chemotherapy may develop azoospermia as these two treatments destroy the sperm-producing cells. (breastfeeding24.com)
  • Can secretory azoospermia be cured when it is due to chemotherapy? (invitra.com)
  • Chemotherapy can be a cause and 2% of Azoospermia is of this kind. (ind.in)
  • By evaluating different parameters of the sperm, this biological examination can reveal different sperm abnormalities, such as azoospermia that is a complete absence of sperm. (apsense.com)
  • Hello, my man is suffering from azoospermia and we are desperate to find a way towards pregnancy. (invitra.com)
  • This chemical combination resulted in a 96% azoospermia and a 99% pregnancy prevention eight years follow injection in humans. (wikipedia.org)
  • Interestingly, TESE if done rightly can give a success rate if 50%, thus allowing many men with azoospermia to father their own biological children. (andrologycorner.com)