A semisynthetic ampicillin-derived acylureido penicillin.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
An antibiotic derived from penicillin similar to CARBENICILLIN in action.
Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients.
Infections with bacteria of the genus PSEUDOMONAS.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Services providing pharmaceutic and therapeutic drug information and consultation.
Printed publications usually having a format with no binding and no cover and having fewer than some set number of pages. They are often devoted to a single subject.
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
The teaching or training of patients concerning their own health needs.
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.
High molecular weight, insoluble polymers which contain functional groups that are capable of undergoing exchange reactions (ION EXCHANGE) with either cations or anions.
High molecular weight insoluble polymers which contain functional anionic groups that are capable of undergoing exchange reactions with cations.
High-molecular-weight insoluble polymers that contain functional cationic groups capable of undergoing exchange reactions with anions.
Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
A plant species of the genus PINUS that contains isocupressic acid.
Polymers of high molecular weight which at some stage are capable of being molded and then harden to form useful components.
A chlorinated epoxy compound used as an industrial solvent. It is a strong skin irritant and carcinogen.
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
A shared service which combines the purchasing power of individual organizations or facilities in order to obtain lower prices for equipment and supplies. (From Health Care Terms, 2nd ed)
Injury to any part of the eye by extreme heat, chemical agents, or ultraviolet radiation.
Proteins isolated from the outer membrane of Gram-negative bacteria.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Proteins obtained from ESCHERICHIA COLI.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Sequential operating programs and data which instruct the functioning of a digital computer.
The portion of an interactive computer program that issues messages to and receives commands from a user.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.
An imidazole antifungal agent that is used topically and by intravenous infusion.
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.

Ability of azlocillin and tobramycin in combination to delay or prevent resistance development in Pseudomonas aeruginosa. (1/60)

The ability of combinations of azlocillin and tobramycin to prevent or delay resistance development in eight Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients was studied using chequerboard titration and in-vitro serial subculture. No isolate had developed resistance to tobramycin after 12 treatments with the antibiotic combination. Azlocillin resistance had not developed in four isolates after 16 exposures, and was delayed in the other four isolates for at least eight exposures. Beta-lactamase production was responsible for azlocillin resistance in two isolates and occurred to a lesser extent in a third.  (+info)

Once-daily versus multiple-daily gentamicin in empirical antibiotic therapy of febrile neutropenia following intensive chemotherapy. (2/60)

The clinical efficacy and toxicity of once-daily compared with multiple-daily gentamicin dosing, in combination with azlocillin, were studied retrospectively in febrile neutropenic episodes following intensive chemotherapy. Fifty-two episodes were studied in 28 patients with acute myeloid leukaemia. Reasons for initiation of antibiotic therapy, dose, duration of treatment, organism isolation rates, response, cost comparison and toxicity were studied in the two treatment groups. The main indication for initiation of antibiotic therapy was neutropenic fever without a documented infection (80.8% of episodes). The response rate to once-daily gentamicin dosing and azlocillin was three times higher than to multiple-daily gentamicin dosing and azlocillin (P = 0.0112). The incidence of toxicity was low overall and was slightly but not significantly higher in the once-daily group. In this clinical context once-daily gentamicin at a dose of 7 mg/kg/day is more effective than a multiple-daily dosing regimen but may be more toxic.  (+info)

Reduction of contamination of mycobacterial growth indicator tubes with a modified antimicrobial combination. (3/60)

Culture in the fluorimetric Mycobacteria Growth Indicator Tube (MGIT) treated with a combination of vancomycin, amphotericin B, and nalidixic acid (VAN) showed growth of most strains of 31 mycobacterial species with a less-than-1-day delay. The results were similar to those in the MGIT with polymyxin B, amphotericin B, nalidixic acid, trimethoprim, and azlocillin, but with respiratory specimens, the MGIT with VAN showed a lower contamination rate with no change in the detection rate or time.  (+info)

A murein hydrolase is the specific target of bulgecin in Escherichia coli. (4/60)

A deletion in the structural gene for the soluble lytic transglycosylase, the predominant murein hydrolase in the soluble fraction of Escherichia coli, has been constructed. The mutant grows normally but exhibits increased sensitivity toward mecillinam, a beta-lactam specific for penicillin-binding protein 2. In the presence of furazlocillin or other beta-lactams with a specificity for penicillin-binding protein 3 which normally cause filamentation, bulges were formed prior to rapid bacteriolysis. Similar morphological alterations are known to develop in wild type E. coli cells when furazlocillin is combined with bulgecin, an antibiotic of unusual glucosaminyl structure. It turned out that bulgecin specifically inhibits the Sl-transglycosylase in a noncompetitive manner. Since bulgecin shows some structural analogy to the murein subunits we postulate that the soluble lytic transglycosylase, in addition to its active site, has a recognition site for specific murein structures. The possibility of an allosteric modulation of the activity of the enzyme by changes in the structure of the murein sacculus is discussed.  (+info)

Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase. (5/60)

Penicillin-binding proteins (PBPs) catalyze the essential reactions in the biosynthesis of cell wall peptidoglycan from glycopeptide precursors. beta-Lactam antibiotics normally interfere with this process by reacting covalently with the active site serine to form a stable acyl-enzyme. The design of novel beta-lactams active against penicillin-susceptible and penicillin-resistant organisms will require a better understanding of the molecular details of this reaction. To that end, we compared the affinities of different beta-lactam antibiotics to a modified soluble form of a resistant Enterococcus faecium PBP5 (Delta1-36 rPBP5). The soluble protein, Delta1-36 rPBP5, was expressed in Escherichia coli and purified, and the NH(2)-terminal protein sequence was verified by amino acid sequencing. Using beta-lactams with different R1 side chains, we show that azlocillin has greater affinity for Delta1-36 rPBP5 than piperacillin and ampicillin (apparent K(i) = 7 +/- 0.3 microM, compared to 36 +/- 3 and 51 +/- 10 microM, respectively). Azlocillin also exhibits the most rapid acylation rate (apparent k(2) = 15 +/- 4 M(-1) s(-1)). Meropenem demonstrates an affinity for Delta1-36 rPBP5 comparable to that of ampicillin (apparent K(i) = 51 +/- 15 microM) but is slower at acylating (apparent k(2) = 0.14 +/- 0.02 M(-1) s(-1)). This characterization defines important structure-activity relationships for this clinically relevant type II transpeptidase, shows that the rate of formation of the acyl-enzyme is an essential factor determining the efficacy of a beta-lactam, and suggests that the specific side chain interactions of beta-lactams could be modified to improve inactivation of resistant PBPs.  (+info)

Invalidity for Pseudomonas aeruginosa of an accepted model of bacterial permeability to beta-lactam antibiotics. (6/60)

The accepted model for the penetration of beta-lactam antibiotics into gram-negative bacteria is that proposed by Zimmermann and Rosselet (Antimicrob. Agents Chemother. 12:368-372, 1977). The model assumes (i) that diffusion of the antibiotic molecules across the outer membrane obeys Fick's law and can be characterized by a permeability constant for any given combination of organism and drug, (ii) that drug hydrolysis within the periplasm obeys Michaelis-Menten kinetics, and (iii) that a steady state is rapidly attained between drug uptake and hydrolysis. The model has allowed accurate prediction of antibiotic MICs for Escherichia coli strains from a knowledge of their beta-lactamase production and permeability characteristics. It has been suggested that the model is inappropriate for Pseudomonas aeruginosa, but attempts to confirm this have been bedevilled by experimental difficulties in estimating permeability coefficients for this species. In the present study, we tested a prediction of the model that the overall resistance of P. aeruginosa transconjugants containing a plasmid-encoded beta-lactamase should continue to depend partly on permeability. Transconjugants with PSE-4 beta-lactamase were constructed in host strains with widely different levels of intrinsic, presumably impermeability-determined resistance. Contrary to the prediction of the model, all the transconjugants developed identical overall levels of resistance to substrate beta-lactams, such as azlocillin and cefoperazone, irrespective of the initial levels of intrinsic resistance of the recipient strains. We conclude that the model is inappropriate for P. aeruginosa, and possible explanations for the organism's behavior are discussed.  (+info)

Partitioning of a mini-F plasmid into anucleate cells of the mukB null mutant. (7/60)

The partition-proficient mini-F plasmid pXX325 was stably maintained in the mukB null mutant, which is defective in chromosome partitioning into the two daughter cells. In the null mutant, the plasmid was partitioned into both nucleate and anucleate daughter cells, independently of host chromosomes.  (+info)

Contrasting patterns of phylogeographic relationships in sympatric sister species of ironclad beetles (Zopheridae: Phloeodes spp.) in California's Transverse Ranges. (8/60)

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TY - JOUR. T1 - Susceptibilities of enterococci to twelve antibiotics. AU - Tofte, R. W.. AU - Solliday, J. A.. AU - Crossley, K. B.. PY - 1984. Y1 - 1984. N2 - The susceptibilities of 347 urine isolates of enterococci (Streptococcus faecalis, 44%; S. faecalis subsp. zymogenes, 37%; S. faecalis subsp. liquefaciens, 19%) to ampicillin, azlocillin, mezlocillin, piperacillin, vancomycin, gentamicin, erythromycin, rosaramicin, rifampin, rifampin plus trimethoprim (1:4), trimethoprim-sulfamethoxazole (1:20), and chloramphenicol were determined by the agar dilution technique. There were no significant differences in susceptibility to individual agents among the subspecies of S. faecalis. Azlocillin and mezlocillin (MIC for 90% of isolates, 0.78 μg/ml) and piperacillin, ampicillin and vancomycin (MIC for 90% of isolates, 1.56 μg/ml) were the most active agents and were significantly more potent than the other reference antibiotics tested.. AB - The susceptibilities of 347 urine isolates of ...
The in vitro activity of cefepime was compared to that of ceftazidime, ceftriaxone, and cefotaxime in a multicenter study involving 10 clinical microbiology laboratories and clinical isolates from 18 Brazilian hospitals from 7 cities (4 states). A total of 982 isolates consecutively collected between December 1995 and March 1996 were susceptibility tested by using Etest and following the NCCLS procedures for agar diffusion tests. The cefepime spectrum was broader than that of the other broad-spectrum cephalosporins against both Gram-negative rods and Gram-positive cocci. Cefepime tons particularly move active against Enterobacter sp. (MIC90, 2 mu g/ml), Serratia sp. (MIC90, 2 mu g/ml) and oxacillin-susceptible Staphylococcus aureus (MIC90, 3 mu g/ml). Against Pseudomonas aeruginosa, cefepime (MIC90 16 mu g/ml) was slightly more active than ceftazidime (MIC90 32 mu g/ml) and 8- to 16-fold more active than ceftriaxone or cefotaxime (MIC90 ,256 mu g/ml). Our results show that nosocomial bacteria, ...
our company is founded in 1989,and the main product is apicillin sodium,piperacillin sodium,sulbactam sodium,azlocillin sodium and mezlocillin sodium.and
This study examined the effects of fasting in patients with acute heart failure (AHF) using data from a large multi-center heart failure registry. Effect of dietary tadalafil prix en pharmacie fat in isocaloric rations on the nitrogen content of milk from Holstein cows. Changing epidemiology of pediatric Staphylococcus aureus bacteremia in Denmark from 1971 through 2000. The isolated and hydrogen bonded groups are the most important as these readily exchange with D(2)O and thus are exposed to reactant molecules.. In the other 3 patients azlocillin levels of 23 and 39 micrograms/ml and moderate bactericidal activity against P. The plasma membrane of eukaryotic cells tadalafila is the limit to interact with the environment. Primary bladder stone is a common pediatric surgical problem in developing countries.. Dentists reflected that their VIG session had been insightful and considered the review process as beneficial to communication skills training in dentistry. The objective of this study was to ...
The design and implementation of a new input switching capacitive microaccelerometer interface circuit with /spl mu/g resolution is presented. The accelero
Two different strains of Escherichia coli exhibiting unusual patterns of resistance to beta-lactam antibiotics were isolated from patients at Cochin Hospital. Both isolates showed a low level of resistance to amoxycillin, ticarcillin and ureidopenicillins but were susceptible to cephalosporins, aztreonam and imipenem; beta-lactamase inhibitors potentiated the activities of the beta-lactams to only a limited extent. All resistance characteristics of the strains were transferable by conjugation to E. coli K12. Resistance was shown to be due to beta-lactamases of pI 5.20 and relative molecular masses of 24,000. The hydrolytic and inhibition profiles of these enzymes were similar to each other but differed from those of broad-spectrum beta-lactamases (TEM-1). The rates of hydrolysis (Vmax) of amoxycillin (c. 200%) were higher than that for TEM-1 (84%). Ticarcillin, ureidopenicillins and cephaloridine were hydrolyzed slowly. However, as for TEM-1, no hydrolysis was observed with cefoxitin, third generation
beipackzettel ciprofloxacin prednisolone 20 mg zentiva betamethasone cialis yellow pills remedio original. online blood in urine accutane is it allowed.European Scientific Journal November 2015 edition vol.11 CHRONIC URINARY TRACT INFECTION: ETIOLOGICAL AGENTS AND SUSCEPTIBILITY TESTING Dr. Nawal S. Faris 0 0.Ciprofloxacin; Amikacin; Aminoglycosides; Azlocillin; Aztreonam; Anti-Infective Agents; Phenazines; Cephalosporins; Polymyxins; Piperacillin; Siderophores; Hydrogen.Ciprofloxacine; Norfloxacine; Ofloxacine; Macrolides: azithromycine; Rifamycine; Antiglaucomateux. Voie générale. Inhibiteur de lanhydrase carbonique.toutou ÉnergisÉ tout tout guÉrit ♥ ♥ angel mascotte ♥ ♥ du. les animaux sont de petits anges envoyÉs sur la terre pour aider les humains qui souffrent.Looking for a cefixime? Not a problem! Guaranteed Worldwide Shipping Discreet Package Low Prices 24/7/365 Customer Support 100% Satisfaction Guaranteed. Visit This ...
Thin Al foils of 50 mu g/cm/sup 2/ thickness were implanted with /sup 4/He ions with fluences ranging between 10/sup 17/ and 10/sup 18/ atoms/cm/sup 2/. The bulk He contents was measured by the Rutherford backscattering method. The He implantation profile versus depth was obtained by elastic recoil detection analysis. He-implanted targets will be used to measure ( alpha , gamma ) reactions of astrophysical interest, in inverse kinematics. ...
The effect of in vivo fentanyl treatment on synaptic transmission was studied in the CA1 area of the rat hippocampus. Animals were treated either with saline or fentanyl (4 x 80 mu g/kg, s.c./15 min). Intracellular in vitro ...
We have measured the in-vitro activity of 27 antimicrobials against 211 clinical and ten reference strains of Pseudomonas pseudomallei. Imipenem was the most active antibiotic tested, followed by piperacillin, doxycycline, amoxycillin/clavulanic acid, cefixime, cefetamet, azlocillin and ceftazidime, all of which had MICs of less than or equal to 2 mg/l for the majority of strains. The measured MICs were dependent on the media and inocula used, to an extent which varied with the antibiotic class under test; MICs of ureidopenicillins were particularly inoculum-dependent. The beta-lactams and ciprofloxacin were bactericidal, whereas the agents conventionally used to treat melioidosis (doxycycline, chloramphenicol, sulphamethoxazole and trimethoprim) had bacteriostatic activity only. Strains highly resistant to chloramphenicol (MIC greater than or equal to 256 mg/l) emerged during treatment in 7.1% of patients. These strains were fully virulent, and frequently showed cross-resistance to tetracyclines,
Read Conserved genomes of ΦKMV-like bacteriophages (T7 supergroup) active on Pseudomonas aeruginosa, Russian Journal of Genetics on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Objectives: Exposure to fine particles in urban air has been associated with a number of negative health effects. High levels of fine particles have been detected at underground stations in big cities. We investigated the exposure conditions in four occupational groups in the Stockholm underground train system to identify high-exposed groups and study variations in exposure.. Methods: PM1 and PM2.5 were measured during three full work shifts on 44 underground workers. Fluctuations in exposure were monitored by a real-time particle monitoring instrument, pDR, DataRAM. Qualitative analysis of particle content was performed using inductively coupled plasma mass spectrometry. Nitrogen dioxide was measured using passive monitors.. Results: For all underground workers, the geometric mean (GM) of PM1 was 18 mu g/m(3) and of PM2.5 was 37 mu g/m(3). The particle exposure was highest for cleaners/platform workers, and the GM of PM1 was 31.6 mu g/m(3) [geometric standard deviation (GSD), 1.6] and of PM2.5 ...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
to produce (somebody) appear absurd or stupid. He produced an actual idiot of her by promising to marry her and afterwards leaving her when he had expended all her income. iemand belaglik maak; iemand vir die gek hou يَجْعَلُه أضْحوكَةً правя на глупак fazer de tolo dělat si blázny z jemanden zum Narren halten gøre en til grin; gøre nar af en γελοιοποιώ poner en ridículo narriks tegema احمق جلوه دادن saattaa jk naurunalaiseksi rendre ridicule לְשָׁטוֹת किसी को बेवकूफ बनाना praviti budalu od nekoga bolonddá tesz vkit mengejek, memperolok-olokkan, mengelabui gera að fileífli farsi gioco di ばかにする 바보 취급하다 pastatyti į kvailio padėtį apmuļķot; nostādīt kādu muļķīgā stāvoklī memperbodoh-bodohkan voor gek zetten latterliggjøre robić durnia z, wystrychnąć na dudka احمقی fazer de parvo a-şi bate joc de одурачить robiť si blázna z osmešiti ...
Four lichen acids, physodalic acid (F1), physodic acid (F2), 3-hydroxyphysodic acid (F3), and isophysodic acid (F4), were isolated from Hypogymnia physodes methanol extract using preparative reversed-phase high performance liquid chromatography and their structures were determined by UV, MS, H-1 NMR and C-13 NMR. This is the first report on the isolation of F4 from H. physodes. Isolated rat thymocytes were cultivated with increasing F1-F4 concentrations (0.1, 1, 10 mu g/well) and proliferative activity, viability, ROS (reactive oxygen species) production and MMP (mitochondrial membrane potential) disturbances were evaluated. Obtained results show significantly decreased thymocytes proliferation was observed when cells were treated with F1 (1 mu g, p LT 0.05; 10 mu g; p LT 0.001), F2 (10 mu g, p LT 0.05) and F3 compound (10 mu g, p LT 0.05). Significantly increased cytotoxicity was detected when cells were incubated with F1 (1 mu g, p LT 0.05; 10 mu g, p LT 0.01), F2 (10 mu ...g, p LT 0.05) and ...
BioAssay record AID 165188 submitted by ChEMBL: In vitro antibacterial activity of compound was measured on Pseudomonas aeruginosa IAM 1095.
Groups of four adult male rats [ZUR:SIV -Z] were pretreated with corn oil (control; 2 ml/kg/day i. p. for 3 days), trans-stilbene-oxide (SO; 200 mg/kg/day i. p. for 2 days), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 10 \(\mu\)g/kg i. p. once, 4 days before killing), phenobarbital (PB; 1 gjliter in the drinking water for 8 days), and dieldrin (20 mg/kg/day i. p. for 3 or 9 days). They received an injection of [G-\(^3\)H]benzo(a)pyrene (BaP, 31 \(\mu\)g/kg, 7.4. 10\(^9\) dpm/kg; i. v.) 16 h before killing. In the liver of each rat, five enzymatic activities and the covalent binding of BaP to DNA have been determined. The rnicrosomal aryl hydrocarbon monooxygenase activity (AHM) ranged frorn 75% of control (SO) to 356% (TCDD), the nuclear AHM from 63% (SO) to 333% (TCDD). Microsomal epoxide hydrolase activity (EH) was induced up to 238% (PB), nuclear EH ranged from 86% (TCDD) to 218% (PB). A different extent of induction was observed in the two compartments. Highest induction of glutathione ...
In this work, we have investigated theoretically the structure/hyperpolarizability correlations of push-pull molecules sing a two-form two-state model. For this, we have defined a parameter MIX characterizing the mixing between the two-limiting resonance forms and thus ruling the molecular structure and polarization. Also, we have analyzed the solvent effect on the structure and on the polarizabilities of push-pull molecules using the Onsager reaction field theory. We have shown that the dependences of the linear and nonlinear polarizabilities on the solvent dielectric constant look similar to the structure/(hyper)polarizability correlations. Finally, we have investigated experimentally the solvent effect on a series of push-pull polyenes of increasing length. In particular, we have determined the scalar (mu) g(Beta) (0) product (where (mu) g is the ground-state dipole and (Beta) (0) the vector part of static quadratic hyperpolarizability tensor) in different solvents using the ...
Takei Y, however, is often short meidcation so take into account side-effects such as proximal myopathy and poor wound healing. Opal SM, Jhung JW, Keith JC Jr, et al Recombinant human interleukin-11 in experimental Pseudomonas aeruginosa sepsis in immunocompromised animals. The size of the system and the amount of in-house (vs.
Background and purpose:The present study reports on the preparation and testing of a sustained delivery system for the immunomodulatory peptide P10 aimed at reducing the in vivo degradation of the peptide and the amount required to elicit a protective immune response against paracoccidioidomycosis.Experimental approach:BALB/c mice were infected with the yeast Paracoccidioides brasiliensis to mimic the chronic form of paracoccidioidomycosis. the animals were treated daily with sulfamethoxazole/trimethoprim alone or combined with peptide P10, either emulsified in Freunds adjuvant or entrapped in poly(lactic acid-glycolic acid) (PLGA) nanoparticles at different concentrations (1 mu g, 5 mu g, 10 mu g, 20 mu g or 40 mu g center dot 50 mu L-1). Therapeutic efficacy was assessed as fungal burden in tissues and the immune response by quantitative determination of cytokines.Key results:Animals given combined chemotherapy and P10 nanotherapy presented a marked reduction of fungal load in the lungs, ...
Looking for online definition of mezlocillin in the Medical Dictionary? mezlocillin explanation free. What is mezlocillin? Meaning of mezlocillin medical term. What does mezlocillin mean?
The main focus of this study is to mechanistically introduce a new qualitative and quantitative technique for mapping the lipid profile of a sectional brain via non-catalytic transesterification reaction (i.e., pseudo catalytic reaction in the presence of porous materials). One of the biggest technical advances achieved in this study is the qualitative and quantitative analysis of lipid from bovine brain in trace quantities in the magnitude of mu g via the non-catalytic pathway. Moreover, newly introduced derivatization in this work showed high tolerance against impurities (i.e., water and extractives ...
Medical information for Ticarcillin on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Increasing the stability and lifetime of the electrodes is one of the most important factors in order to realise a large scale use of polymer electrolyte membrane fuel cells (PEMFC). By using well-defined thin-film model electrodes, the stability of Pt and Pt on Ir were examined as cathode catalysts in a single cell PEMFC setup. The electrodes were fabricated by evaporating thin layers of Pt and Pt on Ir onto the microporous layer of a gas diffusion layer. The amount of Pt deposited was equivalent to 3 nm (about 6.3 mu g cm(-2)) and the amount of Ir was varied between 1.5 nm and 20 nm (between 3.4 mu g cm(-2) and 45.3 mu g cm(-2)). All samples with Ir showed an increased stability over samples with sole Pt during cyclic corrosion test between 0.6V and 1.2V vs. the reversible hydrogen electrode. For thin layers of Ir, the initial activity for the oxygen reduction reaction was equal to or superior to that of sole Pt but for thicker Ir films it was somewhat lower. Hydrogen underpotential deposition ...
Objective: The paper describes the results of a polycentric study for the assessment of reference values of urinary chromium (U-Cr) in the Italian population. Method: A total of 890 subjects (58.3% males and 41.7% females) were selected on the basis of standardized criteria in eight different areas of Italy. Urinary chromium was determined on morning spot samples collected using standardized procedures. The U-Cr was determined independently by three laboratories using an Electrothermic atomization-Atomic Absorption Spectrometry (ETA-AAS) method with a detection limit of 0.05 mu g/l, adopting - for the statistical analysis - the median value of the results of the three laboratories. The between-laboratories within-subjects standard deviation was 0.049 mu g/l. Due to the high proportion (approx. 28%) of undetectable chromium levels, the geometric mean (GM) and geometric standard deviation (GSD) were estimated using a procedure of linear interpolation. The analysis of the effects of some variables ...
Xenopus laevis larvae were exposed to cadmium (Cd) at 0, 1, 8. 85 or 860 mu g L(-1) in FETAX medium from 0 to 86 d postfertilization. Premetamorphic tadpoles were sampled on day 3 1; pre and prometamorphic tadpoles on day 49; and frogs (NF stage 66) between days 50 and 86. Survival, snout-vent length (SVL), tail length, total length, hindlimb.... Sharma, Bibek; Patino, Reynaldo ...
Fourteen people graded their aches and pains and general health for 28 days. They then took either up to 500 mu g of molybdenum as amino acid chelate per day, or placebo for the next 28 days, while they continued their records. The groups were crossed over for a third 28-day period. Their aches and pains improved on molybdenum (significant at the 0.05 level). Their general health also improved on molybdenum (significant at the 0.025 level). Suggestions are made for categories of people who may benefit from molybdenum supplementation, and for areas of further research.. ...
Fourteen people graded their aches and pains and general health for 28 days. They then took either up to 500 mu g of molybdenum as amino acid chelate per day, or placebo for the next 28 days, while they continued their records. The groups were crossed over for a third 28-day period. Their aches and pains improved on molybdenum (significant at the 0.05 level). Their general health also improved on molybdenum (significant at the 0.025 level). Suggestions are made for categories of people who may benefit from molybdenum supplementation, and for areas of further research.. ...
Multidrug-resistant tuberculosis (TB) threatens TB control worldwide. The microscopic observation drug susceptibility (MODS) assay is a low-cost, high-performance TB diagnostic tool for rapid liquid culture and direct isoniazid and rifampicin drug susceptibility testing (DST). The objective of this study was to explore the potential for extending the MODS assay to rapid second-line DST and to identify critical concentrations of candidate drugs for prospective testing. Sputum samples from 94 TB culture-positive patients receiving second-line TB agents were cultured following standardised MODS protocols, with a range of titrations of antimicrobial drugs added. Critical concentrations were determined using a modified Kaplan-Meier survival curve analysis. Candidate critical concentrations were determined for capreomycin (10 mu g.mL(-1)), ciprofloxacin (1.25 mu g.mL(-1)), cycloserine (40 mu g.mL(-1)), ethambutol (10 mu g.mL(-1)), ethionamide (5 mu g.mL(-1)), kanamycin (5 mu g.mL(-1)) ...
TY - JOUR. T1 - High-pressure liquid chromatographic assay of cefotaxime and desacetylcefotaxime in human myometrium. AU - Bawdon, R. E.. AU - Novick, W. J.. AU - Hemsell, D. L.. AU - Welch, W. D.. PY - 1984. Y1 - 1984. N2 - An analytic high-pressure liquid chromatographic (HPLC) procedure for the assay of desacetylcefotaxime and cefotaxime in gynecologic tissue was developed. Normal individuals undergoing elective hysterectomy were subjects in this study. Blood and myometrium were removed up to four hours after a l-g intramuscular dose of cefotaxime. Since cefotaxime is unstable in homogenized tissue at room temperature, the specimens must be maintained at 4 degree C during homogenization and extraction. Mean serum desacetylcefotaxime and cefotaxime levels were 3. 2 plus or minus 2. 0 mu g/ml and 6. 8 plus or minus 4. 4 mu g/ml, respectively. The mean myometrium concentrations of desacetylcefotaxime and cefotaxime were 8. 4 plus or minus 10. 0 mu g/g and 6. 3 plus or minus 8. 9 mu g/g, ...
The present study was undertaken to investigate the antioxidative and anti-inflammatory activities of the extract of the flower of Campsis grandiflora (Thunb.) K. Schum. Exposure of human dermal fibroblasts to 50% EtOH extract of Campsis grandiflora flower (ECG) at 10 and 100 mu g/ml showed significant protective effect against hydrogen peroxide (300 mu M). ECG not only protected cell survival from H2O2-induced toxicity, but also inhibited the H2O2-induced leakage of lactate dehydrogenase (LDH) enzyme release and DNA fragmentation significantly. It was also found that ECG showed scavenging activities of radicals and reactive oxygen species with IC50 values of 20 mu g/ml against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 52 mu g/ml against superoxide radicals in the xanthine/xanthine oxidase system, respectively. Topically applied ECG dose-dependently inhibited arachidonic acid (AA)- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in mice. Consistent with its antioxidative ...
phospho-N-acetylmuramoyl pentapeptide transferase: enzyme important in murein synthesis which transfers the N-acetylmuramoylpentapeptide to a membrane-bound carrier that is a C-55 terpene alcohol phosphate; minor descriptor (75-84); on-line & Index Medicus search PHOSPHOTRANSFERASES (75-84)
Penicillin Penicillin is a group of antibiotic Benzylpenicillin penicillin G Benzylpenicilloyl-polylysine (BPP) Phenoxymethyl penicillin s penicillin V Semi-synthetic Penicillins Methicillin Nafcillin Cloxacillin Dicloxacillin Ampicillin Amoxicillin Bacampicillin Pivampicillin Carbenicillin Ticarcillin Azlocillin Mezlocillin Piperacillin Hetacillin Penicillins approved for veterinary use
The objective of this study was to evaluate the sub-lethal toxicity of hexabromocyclododecane (HBCDD) in fish. Adult Chinese rare minnows as in vivo models were exposed to waterborne HBCDD from 1 to 500 mu g/l for 14, 28 and 42 days. Hepatic CYP1A1 (ethoxyresorufin-O-deethylase, EROD) and CYP2B1 (pentaoxyresorufin-O-depentylase, PROD) activities were measured. At the same time, molecular biomarkers of oxidative stress were also assayed in the brain, including reactive oxygen species (ROS), lipid peroxidation products (thiobarbituric acid-reactive substances, TBARS), DNA damage and protein carbonyl, as well as superoxide dismutase (SOD) activity and glutathione (GSH) content. DNA damage was evaluated using the Comet assay on erythrocytes. Besides, the content of HBCDD in whole fish was determined after 42 days exposure. The results show that HBCDD could induce EROD and PROD at 500 mu g/l after 28 days exposure, and at 100 to 500 mu g/l after 42 days exposure (P < 0.05), respectively. ROS ...
Biochemical analyses can point to toxicant presence before its effects can be detected at higher organizational levels. We investigated responses of larval mass and alkaline phosphatase (ALP) to different cadmium treatments in 4th instar gypsy moth larvae from 20 full-sib families. Changes in trait values and trait plasticities as well as their variation were monitored after acute and chronic exposure or recovery from two cadmium concentrations (Cd(1) = 10 mu g and Cd(2) = 30 mu g Cd/g dry food). Larval mass only decreased, without returning to the control level at recovery stage following chronic cadmium challenge. Acute stress did not change trait value but increased genetic variance of larval mass. Significant ALP activity changes, sensitivity of isozyme patterns (Mr of 60, 64, and 85 kDa) and increased variation in ALP plasticity during acute exposure to cadmium point to its possible aplication as an exposure biomarker. (C) 2008 Elsevier Inc. All rights reserved ...
Norway lobsters, Nephrops norvegicus were exposed for 18 days to combinations of cadmium, copper and zinc st three sublethal concentrations (1, 5, 25 mu g/L for Cd and Cu, and 8, 40 and 200 mu g/L for Zn). Male animals were exposed to all three concentrations, while female animals were studied only in one (highest) concentration of the metals. Activities of Na,K-ATPase and both oligomycin-sensitive and insensitive Mg-ATPase were investigated in relation to metal exposure. A group of male Nephrops of different size groups from a single location in the Clyde Sea was also sampled to investigate the relationship between size and ATPase activity. ...
September 2016 - BronchUK team publish on Pseudomonas and microbial cross infection and evolution in bronchiectasis in the European respiratory ...
Emissions of Volatile Organic Compounds (VOCs) at oil transfer stations are high and the primary pollutants of concern from a health perspective include benzene, toluene, ethylbenzene, and xylene (BTEX) BTEX. This exploratory study investigated personal exposure to BTEX through environmental air samples collected from 50 workers (tanker loading workers, tank-gauging workers, drivers, firefighters, and office workers) at a major oil distribution company in Iran. Airborne BTEX exposures were evaluated over 8-hour periods during work-shift by using personal passive samplers. Measured mean values for workers at four sites were, respectively, 2437, 992, 584, and 2788 mu g/m(3) for benzene; 4415, 2830, 1289, and 9407 mu g/m(3) for toluene; 781, 522, 187, and 533 mu g/m(3) for ethylbenzene; and 1134, 678, 322, and 525 mu g/m(3) for xylene. Exposure across job type was similarly stratified across all personal exposures to BTEX measured in air samples with maximum concentrations found for tanker loading ...
The galactose specific lectin LecA partly mediates the formation of antibiotic resistant biofilms by Pseudomonas aeruginosa, an opportunistic pathogen causing lethal airways infections in immunocompromised and cystic fibrosis patients, suggesting that preventing LecA binding to natural saccharides might prov Multivalent Biomolecular Recognition
In order to optimize culture conditions of bovine pulmonary endothelial cells (CPAE), we have compared different culture media, supports and extracellular matrices. Cell biomass was estimated by protein assay using Lowrys method. Different constituents including albumin, hydrocortisone, insulin, transferrin, triiodotyronine, Epidermal Growth Factor (EGF) and Fibroblast Growth Factor were separately added to Basal Defined Medium (BDM). Among them, BDM supplemented with EGF (1 ng/ml), hydrocortisone (100 nM), insulin (1 mu g/ml), triiodotyronine (2 nM) and linoleic acid complexed to albumin (10 mu g/ml) also named synthetic BDM appeared to be the best serum-free nutritive medium and showed similar results as compared to DMEM supplemented with 10% Fetal Bovine Serum (FBS). Several supports have then been tested including tissue culture polystyrene (as a reference), teflon, polycarbonate or poly(ethylene terephthalate) track-etched membranes. Among them, cells cultivated on surface treated ...
Purpose: To define a mitotane dose for pediatric patients with adrenocortical cancer (ACC) that maintains therapeutic plasma levels (TL) between 14 and 20 mu g/mL and to verify its antitumor efficacy in association with 8 cycles of cisplatin, etoposide, and doxorubicin (CED). Methods: Powdered mitotane was dissolved in a medium chain triglyceride oil and administered to 11 children with ACC (2.4 to 15.4 y of age); an initial low dose was increased to 4 g/m(2)/d. Ten of the 11 children had a germline TP53 R337H mutation. Mitotane plasma levels were determined using high-performance liquid chromatography. Results: The mitotane dose to maintain TL in 7 patients ranged from 1.0 to 5.3 g/m(2)/d. Six children reached mitotane levels of 10 mu g/mL in 3.6 months (1.5 to 5.0mo), whereas 5 children took 8 months (6.5 to 12.5 mo). Minor to partial tumor remission was found in 5 patients (, 1 y) and complete remission was found in 2 patients. Of the 3 patients who are alive at the time of report, 1 patient ...
Azlocillin, cimetidine and probenecid increase blood levels of difloxacin. Compounds (i.e. sucralfate, antacids, multivitamins ...
Drugs featuring this ring system include emicerfont, imidapril, and azlocillin. Dimethylol ethylene urea is the reagent used in ...
The closely related analogue azlocillin is made in essentially the same manner as mezlocillin. but with omission of the ...
... azlocillin MeSH D03.438.260.825.750.050.500 --- mezlocillin MeSH D03.438.260.825.750.050.650 --- piperacillin MeSH D03.438. ... azlocillin MeSH D03.605.084.737.750.050.500 --- mezlocillin MeSH D03.605.084.737.750.050.650 --- piperacillin MeSH D03.605. ...
... azlocillin, and piperacillin). P. aeruginosa is intrinsically resistant to all other penicillins. carbapenems (meropenem, ...
There are three ureidopenicillins in clinical use: Azlocillin Piperacillin Mezlocillin They are mostly ampicillin derivatives ...
Azlocillin Mezlocillin Piperacillin Cefazolin Cephalexin Cephalosporin C Cephalothin Cefaclor Cefamandole Cefuroxime Cefotetan ...
... azlocillin MeSH D02.065.589.099.750.750.050.500 --- mezlocillin MeSH D02.065.589.099.750.750.050.650 --- piperacillin MeSH ...
Ureidopenicillins Azlocillin Mezlocillin Piperacillin Carboxypenicillins Ticarcillin (generally in the combination ticarcillin/ ...
Amoxycillin (p-hydroxy metabolite of ampicillin) Pivampicillin (special pro-drug of ampicillin) Azlocillin and pirbenicillin ( ...
Azlin azlocillin (INN) Azmacort Azo Gantanol Azo Gantrisin Azolid azolimine (INN) Azopt azosemide (INN) azotomycin (INN) ...
J01CA04 Amoxicillin J01CA05 Carindacillin J01CA06 Bacampicillin J01CA07 Epicillin J01CA08 Pivmecillinam J01CA09 Azlocillin ...
... azlocillin 1977 - cefadroxil 1977 - cefamandole 1977 - cefoxitin 1977 - cefuroxime 1977 - mezlocillin 1977 - pivmecillinam 1979 ...
... is considered a broad spectrum antibiotic and can be used against a number of Gram positive and Gram negative ... Azlocillin is an acylampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy ... Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of ... 0.03 μg/mL - 2 μg/mL Pseudomonas aeruginosa 4 μg/mL - 6.25 μg/mL An interesting alternative synthesis of azlocillin involves ...
InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/ ...
The production of benzylpenicillin involves fermentation, recovery and purification of the penicillin.[10] The fermentation process of the production of benzylpencillin is about obtaining the product. The presence of the product in solution inhibits the reaction and reduces the product rate and yield. Thus, in order to obtain the most product and increase the rate of reaction the product, would be continuously extracted out.[11] This is done by having the mold with either glucose, sucrose, lactose, startch, or detrin, nitrate, ammonium salt, corn steep liquor, peptone, meat or yeast extract, and little amounts of inorganic salts.[12] The recovery of the benzylpencillin is the most important part of the production process because it affects the purification steps if done wrong.[10] There are many different types of techniques to recover benzyl penicillin, aqueous two-phase extraction, liquid membrane extraction, microfiltration technique, and solvent subulation[10] Extraction is more commonly ...
... , sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections.[1] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.[1] It is given by injection into a vein.[1] Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection.[1] Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis.[1] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem.[1] Use in pregnancy appears to be safe.[1] It is in the carbapenem family of medications.[1] Meropenem usually results in bacterial death through blocking their ability to make a cell wall.[1] It is more resistant to breakdown β-lactamase producing bacteria.[1] Meropenem was patented in 1983.[2] It was approved for medical use in the United States in 1996.[1] It is on the World Health ...
InChI=1S/C14H15N5O5S2/c1-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24-2)6-4-26-14(15)16-6/h4,8,12H,3H2,1-2H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/ ...
Bonow RO, Carabello BA, Kanu C, et al. (August 2006). "ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons". Circulation. 114 (5): e84-231. doi:10.1161/CIRCULATIONAHA.106.176857. PMID 16880336 ...
Resistance to colistin is rare, but has been described. The first colistin-resistance gene in a plasmid which can be transferred between bacterial strains was found in 2011 in China and became publicly known in November 2015. The presence of this plasmid-borne mcr-1 gene was confirmed starting December 2015 in South-East Asia, several European countries and the United States. It is produced by certain strains of the bacteria Paenibacillus polymyxa. As of 2017[update], no agreement exists about how to look for colistin resistance. The Société Française de Microbiologie [fr] uses a cut-off of 2 mg/l, whereas the British Society for Antimicrobial Chemotherapy sets a cutoff of 4 mg/l or less as sensitive, and 8 mg/l or more as resistant. No standards for measuring colistin sensitivity are given in the US. The plasmid-borne mcr-1 gene has been found to confer resistance to colistin.[35] The first colistin-resistance gene in a plasmid which can be transferred between bacterial strains was found in ...
Penicillin V is sometimes used in the treatment of odontogenic infections.. It is less active than benzylpenicillin (penicillin G) against Gram-negative bacteria.[9][10] Phenoxymethylpenicillin has a range of antimicrobial activity against Gram-positive bacteria that is similar to that of benzylpenicillin and a similar mode of action, but it is substantially less active than benzylpenicillin against Gram-negative bacteria.[9][10]. Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally.. Phenoxymethylpenicillin is usually used only for the treatment of mild to moderate infections, and not for severe or deep-seated infections since absorption can be unpredictable. Except for the treatment or prevention of infection with Streptococcus pyogenes (which is uniformly sensitive to penicillin), therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response.[11] People treated initially with parenteral ...
The in vitro activity of ceftolozane-tazobactam has been examined in five surveillance studies of isolates from Europe and North America.[8] In these studies, ceftolozane-tazobactam was notable for its activity against Pseudomonas aeruginosa, a moderately common cause of hospital-acquired infections that is commonly multi-drug resistant. Ninety percent of P. aeruginosa isolates were inhibited by a ceftolozane-tazobactam at a concentration of 4 μg/mL (MIC90), making it the most potent anti-pseudomonal antibiotic in clinical use. In these same studies, ceftolozane-tazobactam exhibited MIC90 values of ,1 μg/mL for Escherichia coli, Citrobacter koseri, Morganella morganii, Proteus mirabilis, Salmonella species, and Serratia marcescens. Somewhat poorer activity is observed for the Klebsiella and Enterobacter species, with the MIC90 for extended spectrum beta-lactamase (ESBL) expressing Klebsiella pneumonia being ,32 μg/mL. ...
A set of multienzymes (peptide synthase CepA, CepB, and CepC) are responsible for assembling the heptapeptide. (Figure 2). The organization of CepA, CepB, and Cep C closely resembles other peptide synthases such as those for surfactin (SrfA1, SrfA2, and SrfA3) and gramicidin (GrsA and GrsB).[41] Each peptide synthase activates codes for various amino acids to activate each domain. CepA codes for modules 1, 2, and 3. CepB codes for modules 4, 5, and 6, and CepC codes for module 7. The three peptide synthases are located at the start of the region of the bacterial genome linked with antibiotic biosynthesis, and span 27 kb.[41]. After the linear heptapeptide molecule is synthesized, vancomycin has to undergo further modifications, such as oxidative cross-linking and glycosylation, in trans[clarification needed] by distinct enzymes, referred to as tailoring enzymes, to become biologically active (Figure 3). To convert the linear heptapeptide, eight enzymes, open reading frames (ORFs) 7, 8, 9, 10, ...
InChI=1S/C16H21N7O7S3/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2,13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26/h8,14H,3-6,17H2,1-2H3,(H,18,24)(H,25,26)(H,27,28)/t8-,14-,16+/m1/s1 ‹See TfM› ...
... (SEF-di-nir) is a third-generation oral cephalosporin antibiotic sold under the brand names Cefzon and Omnicef. As of 2008, cefdinir, as Omnicef, was the highest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales of its generic versions alone.[1] Cefdinir is structurally similar to cefixime. It was discovered by Fujisawa Pharmaceutical Co., Ltd. (now Astellas) and introduced in 1991 under the brand name Cefzon.[2][3] Warner-Lambert licensed this cephalosporin for marketing in US from Fujisawa.[4] Abbott obtained U.S. marketing rights to Omnicef (cefdinir) in December 1998 through an agreement with Warner-Lambert Company.[5] It was approved by FDA on Dec 4, 1997.[6] It is available in US as Omnicef by Abbott Laboratories and in India as Cednir by Abbott, Kefnir by Glenmark, Cefdair by Xalra Pharma and Cefdiel by Ranbaxy. ...
Ceftolozane exerts bactericidal activities against susceptible gram-negative and gram-positive infections by inhibiting essential penicillin-binding proteins (PBPs), which are required for peptidoglycan cross-linking for bacterial cell wall synthesis, resulting in inhibition of cell wall synthesis and subsequent cell death. Ceftolozane is an inhibitor of PBPs of Pseudomonas aeruginosa (e.g. PBP1b, PBP1c, and PBP3) and E. coli (e.g., PBP3).[6][7] Tazobactam is a potent β-lactamase inhibitor of most common class A and C β-lactamases. Tazobactam has little clinically relevant in vitro activity against bacteria due to its reduced affinity to penicillin-binding proteins; however, it is an irreversible inhibitor of some β-lactamases (certain penicillinases and cephalosporinases) and can covalently bind to some chromosomal and plasmid-mediated bacterial beta-lactamases.[6] The addition of tazobactam strengthens the therapeutic response to ceftolozane, giving it the ability to treat a broader range ...
... is a second-generation cephalosporin antibiotic. It can be used to treat ear infections, skin infections, and other bacterial infections.[citation needed] It comes as a tablet and as a liquid suspension. Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, an article[1] has shown no increased risk for cross-allergy for cefprozil and several other second-generation or later cephalosporins. It was patented in 1983 and approved for medical use in 1992.[2] ...
... has the ability to kill a wide variety of bacteria. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage.[11] Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. Because imipenem is rapidly inactivated by renal dehydropeptidase I, it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. Imipenem/cilastatin, like other carbapenems, binds to bacterial penicillin-binding proteins and interferes with bacterial cell wall integrity and synthesis. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. ...
এজলোসিলিন (Azlocillin). *কার্বেনিসিলিন (Carbenicillin). *মেজলোসিলিন (Mezlocillin). *টিকারসিলিন (Ticarcillin). *পাইপেরাসিলিন ( ...
Ez a szócikk szaklektorálásra, tartalmi javításokra szorul. A felmerült kifogásokat a szócikk vitalapja részletezi. Ha nincs indoklás a vitalapon, bátran távolítsd el a sablont! ...
Azlocillin is considered a broad spectrum antibiotic and can be used against a number of Gram positive and Gram negative ... Azlocillin is an acylampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy ... Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of ... 0.03 μg/mL - 2 μg/mL Pseudomonas aeruginosa 4 μg/mL - 6.25 μg/mL An interesting alternative synthesis of azlocillin involves ...
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
... azlocillin sodium explanation free. What is azlocillin sodium? Meaning of azlocillin sodium medical term. What does azlocillin ... Looking for online definition of azlocillin sodium in the Medical Dictionary? ... azlocillin sodium. azlocillin sodium. [az′lōsil′in] a semisynthetic penicillin antibiotic. indications It is prescribed for ... Azlocillin sodium , definition of azlocillin sodium by Medical dictionary https://medical-dictionary.thefreedictionary.com/ ...
Azlocillin and Mezlocillin: New Ureido Penicillins Message Subject (Your Name) has forwarded a page to you from Antimicrobial ... Azlocillin and mezlocillin were less active than cefazolin against β-lactamase-producing E. coli and Klebsiella strains but ... Azlocillin and Mezlocillin: New Ureido Penicillins. Kwung P. Fu, Harold C. Neu ... The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of ...
Azlocillin is a drug used to treatment infections as a result of Pseudomonas aeruginosa, Escherichia coli, and Haemophilus ... Earlier than utilizing Azlocillin, inform your physician and pharmacist:. *In case you are allergic to Azlocillin or different ... Whats Azlocillin used for?. Azlocillin is a drug used to treatment infections as a result of Pseudomonas aeruginosa, ... Is Azlocillin secure for pregnant or breastfeeding ladies?. There isnt any ample analysis on the dangers of utilizing this ...
Leading Azlocillin sodium CAS 37091-65-9 Manufacturers & Suppliers, find Azlocillin sodium CAS 37091-65-9 Factory & Exporters. ... Azlocillin sodium salt;Monosodium azlocillin;Securopen;Sodium azlocillin;. EINECS:. 253-347-7. Density: Melting Point:. Boiling ... Azlocillin sodium CAS 37091-65-9. Payment Type: L/C,T/T,D/P,Paypal,Money Gram,Western Union. ... Home > Products > Electronic Chemicals > Battery Electrolyte > Azlocillin sodium CAS 37091-65-9 ...
... azlocillin, an antibiotic approved by the Food and Drug Administration, eliminated the bacteria that causes Lyme disease. ... Azlocillin comes out on top. The drug, which is not on the market, was tested in mouse models of Lyme disease at seven-day, 14- ... For the first time, azlocillin was also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, ... In this most recent study, azlocillin, one of the top-20 contenders, was shown to eclipse a total of 7,450 compounds because it ...
N2 - In a multicenter, randomized clinical trial, the efficacy of ciprofloxacin plus azlocillin was compared with that of a ... AB - In a multicenter, randomized clinical trial, the efficacy of ciprofloxacin plus azlocillin was compared with that of a ... In a multicenter, randomized clinical trial, the efficacy of ciprofloxacin plus azlocillin was compared with that of a standard ... Our data suggest that the combination of ciprofloxacin and azlocillin is an effective alternative to ceftazidime and amikacin ...
Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines that affect the CNS with bupropion may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Bupropion may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. Make sure the doctor knows if you have trouble sleeping, get upset ...
Detailed drug Information for Aplenzin. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
penicilina (es); Penisillín (is); Penisilin (ms); Penicillin (en-gb); پنسلين (ps); Пеницилин (bg); پنسلین (pnb); پنسلین (ur); Benseliin (so); Penicilín (sk); Penicillina (oc); 青黴素 (zh-hant); Penicilino (io); Penicilline (gsw); 페니실린 (ko); পেনিচিলিন (as); penicilino (eo); пеницилин (mk); Penicilin (bs); Penicilina (an); পেনিসিলিন (bn); pénicilline (fr); Penisilin (jv); Penicilin (hr); پینی سیلین (lrc); פעניצילין (yi); पेनिसिलिन (mr); penicillin (vi); Penicilīni (lv); Penisillien (af); пеницилин (sr); penicilin (cs); Penicilina (pt-br); Penicillin (sco); Пенициллин (mn); penicillin (nn); penicillin (nb); Pénisilin (su); πενικιλίνη (el); Penicillin (fo); ಪೆನ್ಸಿಲಿನ್ (kn); پێنیسیلین (ckb); penicillin (en); بنسلين (ar); Penisilin (br); Пенициллин (kk); ပင်နီဆီလင် (my); 盤尼西林 ...
ácido carboxílico (es); Карбон қышқылдары (kk-kz); Asid karboksilik (ms); كاربون قىشقىلدارى (kk-cn); Карбоксилна киселина (bg); کاربوکسلک تیزاب (pnb); 羧酸 (zh-hk); Karboxylová kyselina (sk); карбонові кислоти (uk); 羧酸 (zh-hant); 羧酸 (zh-cn); 카복실산 (ko); Carboxylsýra (fo); karboksilata acido (eo); Карбоксилна киселина (mk); Karboksilne kiseline (bs); কার্বক্সিলিক অ্যাসিড (bn); acide carboxylique (fr); Karboksilne kiseline (hr); axit cacboxylic (vi); كاربون قىشقىلدارى (kk-arab); Karbon qışqıldarı (kk-latn); Karboksielsuur (af); карбоксилна киселина (sr); 羧酸 (zh-sg); Карбон қышқылдары (kk-cyrl); karboksylsyre (nn); karboksylsyre (nb); Asam karboksilat (su); 羧酸 (lzh); ترشی کاربۆکسیلی (ckb); carboxylic acid (en); حمض كربوكسيلي (ar); 羧酸 (yue); ...
... and azlocillin with the chromosomal beta-lactamase of Pseudomonas aeruginosa were compared. Imipenem was hydrolyzed very slowly ... Azlocillin, cefotaxime, and ceftriaxone were labile to hydrolysis (kcat, 12-297/min) but induced poorly. Consequently their ... The interactions of imipenem, carbenicillin, cefotaxime, ceftriaxone, and azlocillin with the chromosomal beta-lactamase of ...
Drug: Piperacillin and tazobactam, azlocillin, latamoxef, meropenem, vancomycin Efficacy and safety of antibiotics ...
... azlocillin, bacampicillin, cefamandole, cefonicid, cefotaxime, cefotetan, cefoxitin, ceftriaxone, mezlocillin and piperacillin ... azlocillin, bacampicillin, cefamandole, cefonicid, cefotaxime, cefotetan, cefoxitin, ceftriaxone, mezlocillin, piperacillin, ... azlocillin, bacampicillin, cefamandole, cefonicid, cefotaxime, cefotetan, cefoxitin, ceftriaxone, mezlocillin, piperacillin, ... azlocillin, bacampicillin, cefamandole, cefonicid, cefotaxime, cefotetan, cefoxitin, ceftriaxone, mezlocillin, piperacillin, ...
Citation: Ahmed T. A. Al Tahawy ,Ragaa M. F. Khalaf , In-vitro activity of piperacillin, azlocillin, mezlocillin compared with ... In-vitro activity of piperacillin, azlocillin, mezlocillin compared with amikacin and gentamicin against enterobacteriaceae and ... In-vitro activity of piperacillin, azlocillin, mezlocillin compared with amikacin and gentamicin against enterobacteriaceae and ...
Statistical analysis of data is a crucial component of scientific publication. Authors who are unsure of proper statistical analysis should have their manuscripts checked by a qualified statistician.. The following is a list of important items that must be considered before manuscript submission. Deficiencies in any of these areas may delay review and/or publication.. (i) The same reference (gold) standard should be used for all samples for a given analyte. That reference standard might include more than one test, but it should be used and interpreted consistently for all samples. The reference standard should not include results from the test that is under study.. (ii) Do not use sensitivity or specificity to describe results which compare a new test to a non-reference standard. Use the terms positive percent agreement and negative percent agreement for these results, as recommended by the FDA guidance document Statistical Guidance on Reporting Results from Studies Evaluating ...
Factory Supply High Quality Antibiotic AZLOCILLIN SODIUM CAS:37091-65-9 Basic Info. Name:AZLOCILLIN SODIUM Synonym:Azlocillin; ... Factory Supply High Quality Antibiotic AZLOCILLIN SODIUM CAS:37091-65-9. ...
LSB = lauryl sulfobetaine, CLQ = clioquinol, TET = tetracycline, PEN = penimepicycline, AZL = azlocillin. (B-F) Logarithmic ... Phenotypes were identified for five compounds: lauryl sulfobetaine (LSB), tetracycline, penimepicycline, azlocillin and ...
Azlocillin, cimetidine and probenecid increase blood levels of difloxacin. Compounds (i.e. sucralfate, antacids, multivitamins ...
Azlocillin sodium salt Catalog No. A16422. Quick View .category-products .products-list .btn-quickcart { background: white; ... Azlocillin is an acylampicillin with a broad spectrum against bacteria. Learn More ...
Azlocillin Penicillins with beta-lactamase inhibitors. Penicillins may be combined with beta-lactamase inhibitors to increase ... Amoxicillin • Ampicillin • AzlocillinCarbenicillin • Cloxacillin • Dicloxacillin • Flucloxacillin • Mezlocillin • Nafcillin ...
Tetracycline, Demeclocycline. Passive diffusion so broad. ALL bac + protoza. Absorption is prevented by *(Ca, Mg, Fe2+, Al3+)- dairy, antiacids, supplements. Renal and bile clearance. MOA: 30S A site ( inhibits elongation). Doxycycline more lipid soluble so DOC: Vibrio, Spirochete(rickettsia, borrelia) , Mycoplasma, Chlamydiae, Brucella (w/ rifampin). Mino is very water soluble in tears, saliva= asymptomatic meningococcal carriers, Doxy is lipid and not cleared by renal. TCA resistance: pumps increasing efflux, change in ribosome binding site, inactivates enzyme. Adverse: ^^ clostridium, *bone and teeth(enamel hypolasia or permanent tooth discoloration,photosensitivity**, Demeclocycline (ADH receptor blocker used in SIADH, so never used as ATX) ** Quinolones, Sulfonamides (rash due to sun) ...
Systemic ciprofloxacin; ticarcillin + clavulanic acid; azlocillin; piperacillin. Anaerobic infection. Systemic metronidazole ( ...
Azlocillin. approved. yes. inhibitor. Details. DB01066. Cefditoren. approved, investigational. yes. inhibitor. Details. ...
azlocillin sodium. 64. F04. acedapsone. 17. B05. choline chloride. 65. F05. atomoxetine hydrochloride. ...
Eliopoulos, G. M., and Moellering, R. C. (1982). Azlocillin, mezlocillin, and piperacillin: new broad-spectrum penicillins. Ann ...
  • com)-- Bioo Scientific's MaxSignal[R] Beta-Lactam ELISA Test Kit has been validated for the screening of a wide range of beta-lactam antibiotics including ampicillin, penicillin G, amoxicillin, azlocillin, piperacillin, nafcillin, cloxacillin, oxacillin, cefoperazone, ceftiofur and other beta-lactams in a number of food matrices. (thefreedictionary.com)
  • The interactions of imipenem, carbenicillin, cefotaxime, ceftriaxone, and azlocillin with the chromosomal beta-lactamase of Pseudomonas aeruginosa were compared. (nih.gov)
  • Three-hundred and seventy-two of the isolates were resistant, or had reduced susceptibility, to some or all of azlocillin, carbenicillin, ceftazidime, imipenem and meropenem, and the mechanisms underlying their behaviour were examined. (nih.gov)
  • Those with PSE types were highly resistant to azlocillin and carbenicillin whereas those with OXA enzymes were less resistant to these penicillins. (nih.gov)
  • Chromosomal beta-lactamase derepression was demonstrated in 54 isolates, most of which were resistant to ceftazidime and azlocillin although susceptible to carbenicillin and carbapenems. (nih.gov)
  • For example, in P. aeruginosa inactivation of mexA decreases the MICs of ceftriaxone, cefoperazone, azlocillin, and carbenicillin by a factor of 8 to 128 ( 17 ), and in E. coli the deletion of acrAB decreases the MICs of ampicillin and benzylpenicillin by a factor of 2 to 4 ( 19 ). (asm.org)
  • A new Stanford Medicine study in lab dishes and mice provides evidence that the drug azlocillin completely kills off the disease-causing bacteria Borrelia burgdorferi at the onset of the illness. (stanford.edu)
  • A study provides evidence that the drug azlocillin eliminates the bacteria that cause Lyme disease at the onset of infection in lab mice and cultures. (stanford.edu)
  • Azlocillin, cefotaxime, and ceftriaxone were labile to hydrolysis (kcat, 12-297/min) but induced poorly. (nih.gov)
  • In order to identify effective drug molecules that kill drug-tolerant borrelia we have tested two antibiotics, azlocillin and cefotaxime that were identified by us earlier. (stanford.edu)
  • The in vitro efficacy studies of azlocillin and cefotaxime on drug-tolerant persisters were done by semisolid plating method. (stanford.edu)
  • Our results also demonstrate that azlocillin and cefotaxime can effectively kill in vitro doxycycline-tolerant B. burgdorferi. (stanford.edu)
  • Cefotaxime inhibits cephaloridine and azlocillin decomposition by Enterobacteriaceae . (springer.com)
  • these are azlocillin, gramicidin and cefotaxime. (bayarealyme.org)
  • Azlocillin is an acylampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. (wikipedia.org)
  • Azlocillin is considered a broad spectrum antibiotic and can be used against a number of Gram positive and Gram negative bacteria. (wikipedia.org)
  • Screening thousands of drugs, Stanford scientists determined that in mice, azlocillin, an antibiotic approved by the Food and Drug Administration, eliminated the bacteria that causes Lyme disease. (stanford.edu)
  • 0.03 μg/mL - 2 μg/mL Pseudomonas aeruginosa 4 μg/mL - 6.25 μg/mL An interesting alternative synthesis of azlocillin involves activation of the substituted phenylglycine analogue 1 with 1,3-dimethyl-2-chloro-1-imidazolinium chloride (2) and then condensation with 6-APA. (wikipedia.org)
  • At a concentration of 25 μg/ml, azlocillin inhibited 74% of Enterobacter , 97% of Proteus mirabilis , 64% of Citrobacter , 91% of Pseudomonas aeruginosa , and 82% of Bacteroides strains tested. (asm.org)
  • Azlocillin is a drug used to treatment infections as a result of Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. (benefits-of.com)
  • In a multicenter, randomized clinical trial, the efficacy of ciprofloxacin plus azlocillin was compared with that of a standard regiment of cerftazidime plus amikacin for the initial empiric treatment of fever in neutropenic cancer patients. (northwestern.edu)
  • Our data suggest that the combination of ciprofloxacin and azlocillin is an effective alternative to ceftazidime and amikacin for the initial empiric therapy of febrile neutropenic patients, is generally well tolerated, and avoids the oto- and nephrotoxicity associated with aminoglycoside use. (northwestern.edu)
  • We found that azlocillin completely kills late log phase and 7-10 days old stationary phase B. burgdorferi. (stanford.edu)
  • Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31. (stanford.edu)
  • Methicillin http://www.toku-e.com/Assets/MIC/Azlocillin%20sodium%20salt.pdf H. B. Konig et al. (wikipedia.org)
  • What should be recognized earlier than utilizing Azlocillin? (benefits-of.com)
  • For the first time, azlocillin was also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, indicating that it may work as a therapy for lingering symptoms of Lyme disease. (stanford.edu)
  • 5.Dijkmans BA, Van Der Meer JW, Boekhout-Mussert MJ, Zaal-De Jong M, Mattie H. Prolonged bleeding time during azlocillin therapy. (webmd.com)
  • In this most recent study, azlocillin, one of the top-20 contenders, was shown to eclipse a total of 7,450 compounds because it is more effective in killing B. burgdorferi and causes fewer side effects. (stanford.edu)
  • What negative effects would possibly happen as a result of Azlocillin? (benefits-of.com)
  • Azlocillin, cimetidine and probenecid increase blood levels of difloxacin. (wikipedia.org)