Penicillins
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Mezlocillin
Tobramycin
Carbenicillin
Pseudomonas aeruginosa
Cefsulodin
Microbial Sensitivity Tests
Piperacillin
Aztreonam
Amikacin
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Clavulanic Acids
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Drug Information Services
Pamphlets
Drug Labeling
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Formularies as Topic
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Drug Industry
Medical Records Systems, Computerized
Ion Exchange Resins
Cation Exchange Resins
Anion Exchange Resins
Resins, Plant
Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
Resins, Synthetic
Epichlorohydrin
Counterfeit Drugs
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
Citric Acid
Fraud
Directories as Topic
Group Purchasing
Bacterial Outer Membrane Proteins
Membrane Transport Proteins
Cell Membrane
Neuroaxonal Dystrophies
A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Software
User-Computer Interface
Algorithms
Computational Biology
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Medical Illustration
Dictionaries as Topic
Antifungal Agents
Clotrimazole
Allylamine
Ability of azlocillin and tobramycin in combination to delay or prevent resistance development in Pseudomonas aeruginosa. (1/60)
The ability of combinations of azlocillin and tobramycin to prevent or delay resistance development in eight Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients was studied using chequerboard titration and in-vitro serial subculture. No isolate had developed resistance to tobramycin after 12 treatments with the antibiotic combination. Azlocillin resistance had not developed in four isolates after 16 exposures, and was delayed in the other four isolates for at least eight exposures. Beta-lactamase production was responsible for azlocillin resistance in two isolates and occurred to a lesser extent in a third. (+info)Once-daily versus multiple-daily gentamicin in empirical antibiotic therapy of febrile neutropenia following intensive chemotherapy. (2/60)
The clinical efficacy and toxicity of once-daily compared with multiple-daily gentamicin dosing, in combination with azlocillin, were studied retrospectively in febrile neutropenic episodes following intensive chemotherapy. Fifty-two episodes were studied in 28 patients with acute myeloid leukaemia. Reasons for initiation of antibiotic therapy, dose, duration of treatment, organism isolation rates, response, cost comparison and toxicity were studied in the two treatment groups. The main indication for initiation of antibiotic therapy was neutropenic fever without a documented infection (80.8% of episodes). The response rate to once-daily gentamicin dosing and azlocillin was three times higher than to multiple-daily gentamicin dosing and azlocillin (P = 0.0112). The incidence of toxicity was low overall and was slightly but not significantly higher in the once-daily group. In this clinical context once-daily gentamicin at a dose of 7 mg/kg/day is more effective than a multiple-daily dosing regimen but may be more toxic. (+info)Reduction of contamination of mycobacterial growth indicator tubes with a modified antimicrobial combination. (3/60)
Culture in the fluorimetric Mycobacteria Growth Indicator Tube (MGIT) treated with a combination of vancomycin, amphotericin B, and nalidixic acid (VAN) showed growth of most strains of 31 mycobacterial species with a less-than-1-day delay. The results were similar to those in the MGIT with polymyxin B, amphotericin B, nalidixic acid, trimethoprim, and azlocillin, but with respiratory specimens, the MGIT with VAN showed a lower contamination rate with no change in the detection rate or time. (+info)A murein hydrolase is the specific target of bulgecin in Escherichia coli. (4/60)
A deletion in the structural gene for the soluble lytic transglycosylase, the predominant murein hydrolase in the soluble fraction of Escherichia coli, has been constructed. The mutant grows normally but exhibits increased sensitivity toward mecillinam, a beta-lactam specific for penicillin-binding protein 2. In the presence of furazlocillin or other beta-lactams with a specificity for penicillin-binding protein 3 which normally cause filamentation, bulges were formed prior to rapid bacteriolysis. Similar morphological alterations are known to develop in wild type E. coli cells when furazlocillin is combined with bulgecin, an antibiotic of unusual glucosaminyl structure. It turned out that bulgecin specifically inhibits the Sl-transglycosylase in a noncompetitive manner. Since bulgecin shows some structural analogy to the murein subunits we postulate that the soluble lytic transglycosylase, in addition to its active site, has a recognition site for specific murein structures. The possibility of an allosteric modulation of the activity of the enzyme by changes in the structure of the murein sacculus is discussed. (+info)Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase. (5/60)
Penicillin-binding proteins (PBPs) catalyze the essential reactions in the biosynthesis of cell wall peptidoglycan from glycopeptide precursors. beta-Lactam antibiotics normally interfere with this process by reacting covalently with the active site serine to form a stable acyl-enzyme. The design of novel beta-lactams active against penicillin-susceptible and penicillin-resistant organisms will require a better understanding of the molecular details of this reaction. To that end, we compared the affinities of different beta-lactam antibiotics to a modified soluble form of a resistant Enterococcus faecium PBP5 (Delta1-36 rPBP5). The soluble protein, Delta1-36 rPBP5, was expressed in Escherichia coli and purified, and the NH(2)-terminal protein sequence was verified by amino acid sequencing. Using beta-lactams with different R1 side chains, we show that azlocillin has greater affinity for Delta1-36 rPBP5 than piperacillin and ampicillin (apparent K(i) = 7 +/- 0.3 microM, compared to 36 +/- 3 and 51 +/- 10 microM, respectively). Azlocillin also exhibits the most rapid acylation rate (apparent k(2) = 15 +/- 4 M(-1) s(-1)). Meropenem demonstrates an affinity for Delta1-36 rPBP5 comparable to that of ampicillin (apparent K(i) = 51 +/- 15 microM) but is slower at acylating (apparent k(2) = 0.14 +/- 0.02 M(-1) s(-1)). This characterization defines important structure-activity relationships for this clinically relevant type II transpeptidase, shows that the rate of formation of the acyl-enzyme is an essential factor determining the efficacy of a beta-lactam, and suggests that the specific side chain interactions of beta-lactams could be modified to improve inactivation of resistant PBPs. (+info)Invalidity for Pseudomonas aeruginosa of an accepted model of bacterial permeability to beta-lactam antibiotics. (6/60)
The accepted model for the penetration of beta-lactam antibiotics into gram-negative bacteria is that proposed by Zimmermann and Rosselet (Antimicrob. Agents Chemother. 12:368-372, 1977). The model assumes (i) that diffusion of the antibiotic molecules across the outer membrane obeys Fick's law and can be characterized by a permeability constant for any given combination of organism and drug, (ii) that drug hydrolysis within the periplasm obeys Michaelis-Menten kinetics, and (iii) that a steady state is rapidly attained between drug uptake and hydrolysis. The model has allowed accurate prediction of antibiotic MICs for Escherichia coli strains from a knowledge of their beta-lactamase production and permeability characteristics. It has been suggested that the model is inappropriate for Pseudomonas aeruginosa, but attempts to confirm this have been bedevilled by experimental difficulties in estimating permeability coefficients for this species. In the present study, we tested a prediction of the model that the overall resistance of P. aeruginosa transconjugants containing a plasmid-encoded beta-lactamase should continue to depend partly on permeability. Transconjugants with PSE-4 beta-lactamase were constructed in host strains with widely different levels of intrinsic, presumably impermeability-determined resistance. Contrary to the prediction of the model, all the transconjugants developed identical overall levels of resistance to substrate beta-lactams, such as azlocillin and cefoperazone, irrespective of the initial levels of intrinsic resistance of the recipient strains. We conclude that the model is inappropriate for P. aeruginosa, and possible explanations for the organism's behavior are discussed. (+info)Partitioning of a mini-F plasmid into anucleate cells of the mukB null mutant. (7/60)
The partition-proficient mini-F plasmid pXX325 was stably maintained in the mukB null mutant, which is defective in chromosome partitioning into the two daughter cells. In the null mutant, the plasmid was partitioned into both nucleate and anucleate daughter cells, independently of host chromosomes. (+info)Contrasting patterns of phylogeographic relationships in sympatric sister species of ironclad beetles (Zopheridae: Phloeodes spp.) in California's Transverse Ranges. (8/60)
(+info)
Susceptibilities of enterococci to twelve antibiotics<...
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The antimicrobial susceptibility of Pseudomonas pseudomallei. Emergence of resistance in vitro and during treatment. - Nuffield...
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AID 165188 - In vitro antibacterial activity of compound was measured on Pseudomonas aeruginosa IAM 1095 - PubChem
OPUS Würzburg | Search
Structure/quadratic hyperpolarizability correlation: solvent effect | (1996) | Barzoukas | Publications | Spie
each what is cymbalta medication used for the tumor
Poly(lactic acid-glycolic acid) nanoparticles markedly improve immunological protection provided by peptide P10 against murine...
SciELO - Journal of Venomous Animals and Toxins, Volume: 8, Issue: 2, Published: 2002
Mezlocillin | definition of mezlocillin by Medical dictionary
DHIMAN BANIK
Repository at Hanyang University: Analysis of the lipid profiles in a section of bovine brain via non-catalytic rapid...
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Cooperative Research Units
Molybdenum | ENCOGNITIVE.COM
Molybdenum | ENCOGNITIVE.COM
Second-line anti-tuberculosis drug concentrations for susceptibility testing in the MODS assay - LSHTM Research Online |...
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phospho-N-acetylmuramoyl pentapeptide transferase
Summary Report | CureHunter
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Difloxacin
Azlocillin, cimetidine and probenecid increase blood levels of difloxacin. Compounds (i.e. sucralfate, antacids, multivitamins ...
Imidazolidinone
Drugs featuring this ring system include emicerfont, imidapril, and azlocillin. Dimethylol ethylene urea is the reagent used in ...
Mezlocillin
The closely related analogue azlocillin is made in essentially the same manner as mezlocillin. but with omission of the ...
Ampicillin
Amoxycillin (p-hydroxy metabolite of ampicillin) Pivampicillin (special pro-drug of ampicillin) Azlocillin and pirbenicillin ( ...
Cefuroxime axetil
InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/ ...
Benzylpenicillin
The production of benzylpenicillin involves fermentation, recovery and purification of the penicillin.[10] The fermentation process of the production of benzylpencillin is about obtaining the product. The presence of the product in solution inhibits the reaction and reduces the product rate and yield. Thus, in order to obtain the most product and increase the rate of reaction the product, would be continuously extracted out.[11] This is done by having the mold with either glucose, sucrose, lactose, startch, or detrin, nitrate, ammonium salt, corn steep liquor, peptone, meat or yeast extract, and little amounts of inorganic salts.[12] The recovery of the benzylpencillin is the most important part of the production process because it affects the purification steps if done wrong.[10] There are many different types of techniques to recover benzyl penicillin, aqueous two-phase extraction, liquid membrane extraction, microfiltration technique, and solvent subulation[10] Extraction is more commonly ...
Meropenem
... , sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections.[1] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.[1] It is given by injection into a vein.[1] Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection.[1] Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis.[1] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem.[1] Use in pregnancy appears to be safe.[1] It is in the carbapenem family of medications.[1] Meropenem usually results in bacterial death through blocking their ability to make a cell wall.[1] It is more resistant to breakdown β-lactamase producing bacteria.[1] Meropenem was patented in 1983.[2] It was approved for medical use in the United States in 1996.[1] It is on the World Health ...
Cefetamet
InChI=1S/C14H15N5O5S2/c1-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24-2)6-4-26-14(15)16-6/h4,8,12H,3H2,1-2H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/ ...
Nafcillin
Bonow RO, Carabello BA, Kanu C, et al. (August 2006). "ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons". Circulation. 114 (5): e84-231. doi:10.1161/CIRCULATIONAHA.106.176857. PMID 16880336 ...
Phenoxymethylpenicillin
Penicillin V is sometimes used in the treatment of odontogenic infections.. It is less active than benzylpenicillin (penicillin G) against Gram-negative bacteria.[9][10] Phenoxymethylpenicillin has a range of antimicrobial activity against Gram-positive bacteria that is similar to that of benzylpenicillin and a similar mode of action, but it is substantially less active than benzylpenicillin against Gram-negative bacteria.[9][10]. Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally.. Phenoxymethylpenicillin is usually used only for the treatment of mild to moderate infections, and not for severe or deep-seated infections since absorption can be unpredictable. Except for the treatment or prevention of infection with Streptococcus pyogenes (which is uniformly sensitive to penicillin), therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response.[11] People treated initially with parenteral ...
Ceftolozane
The in vitro activity of ceftolozane-tazobactam has been examined in five surveillance studies of isolates from Europe and North America.[8] In these studies, ceftolozane-tazobactam was notable for its activity against Pseudomonas aeruginosa, a moderately common cause of hospital-acquired infections that is commonly multi-drug resistant. Ninety percent of P. aeruginosa isolates were inhibited by a ceftolozane-tazobactam at a concentration of 4 μg/mL (MIC90), making it the most potent anti-pseudomonal antibiotic in clinical use. In these same studies, ceftolozane-tazobactam exhibited MIC90 values of ,1 μg/mL for Escherichia coli, Citrobacter koseri, Morganella morganii, Proteus mirabilis, Salmonella species, and Serratia marcescens. Somewhat poorer activity is observed for the Klebsiella and Enterobacter species, with the MIC90 for extended spectrum beta-lactamase (ESBL) expressing Klebsiella pneumonia being ,32 μg/mL. ...
Vancomycin
A set of multienzymes (peptide synthase CepA, CepB, and CepC) are responsible for assembling the heptapeptide. (Figure 2). The organization of CepA, CepB, and Cep C closely resembles other peptide synthases such as those for surfactin (SrfA1, SrfA2, and SrfA3) and gramicidin (GrsA and GrsB).[41] Each peptide synthase activates codes for various amino acids to activate each domain. CepA codes for modules 1, 2, and 3. CepB codes for modules 4, 5, and 6, and CepC codes for module 7. The three peptide synthases are located at the start of the region of the bacterial genome linked with antibiotic biosynthesis, and span 27 kb.[41]. After the linear heptapeptide molecule is synthesized, vancomycin has to undergo further modifications, such as oxidative cross-linking and glycosylation, in trans[clarification needed] by distinct enzymes, referred to as tailoring enzymes, to become biologically active (Figure 3). To convert the linear heptapeptide, eight enzymes, open reading frames (ORFs) 7, 8, 9, 10, ...
Cefminox
InChI=1S/C16H21N7O7S3/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2,13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26/h8,14H,3-6,17H2,1-2H3,(H,18,24)(H,25,26)(H,27,28)/t8-,14-,16+/m1/s1 ‹See TfM› ...
Cefdinir
... (SEF-di-nir) is a third-generation oral cephalosporin antibiotic sold under the brand names Cefzon and Omnicef. As of 2008, cefdinir, as Omnicef, was the highest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales of its generic versions alone.[1] Cefdinir is structurally similar to cefixime. It was discovered by Fujisawa Pharmaceutical Co., Ltd. (now Astellas) and introduced in 1991 under the brand name Cefzon.[2][3] Warner-Lambert licensed this cephalosporin for marketing in US from Fujisawa.[4] Abbott obtained U.S. marketing rights to Omnicef (cefdinir) in December 1998 through an agreement with Warner-Lambert Company.[5] It was approved by FDA on Dec 4, 1997.[6] It is available in US as Omnicef by Abbott Laboratories and in India as Cednir by Abbott, Kefnir by Glenmark, Cefdair by Xalra Pharma and Cefdiel by Ranbaxy. ...
Ceftolozane/tazobactam
Ceftolozane exerts bactericidal activities against susceptible gram-negative and gram-positive infections by inhibiting essential penicillin-binding proteins (PBPs), which are required for peptidoglycan cross-linking for bacterial cell wall synthesis, resulting in inhibition of cell wall synthesis and subsequent cell death. Ceftolozane is an inhibitor of PBPs of Pseudomonas aeruginosa (e.g. PBP1b, PBP1c, and PBP3) and E. coli (e.g., PBP3).[6][7] Tazobactam is a potent β-lactamase inhibitor of most common class A and C β-lactamases. Tazobactam has little clinically relevant in vitro activity against bacteria due to its reduced affinity to penicillin-binding proteins; however, it is an irreversible inhibitor of some β-lactamases (certain penicillinases and cephalosporinases) and can covalently bind to some chromosomal and plasmid-mediated bacterial beta-lactamases.[6] The addition of tazobactam strengthens the therapeutic response to ceftolozane, giving it the ability to treat a broader range ...
Cefprozil
... is a second-generation cephalosporin antibiotic. It can be used to treat ear infections, skin infections, and other bacterial infections.[citation needed] It comes as a tablet and as a liquid suspension. Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, an article[1] has shown no increased risk for cross-allergy for cefprozil and several other second-generation or later cephalosporins. It was patented in 1983 and approved for medical use in 1992.[2] ...
Imipenem/cilastatin
... has the ability to kill a wide variety of bacteria. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage.[11] Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. Because imipenem is rapidly inactivated by renal dehydropeptidase I, it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. Imipenem/cilastatin, like other carbapenems, binds to bacterial penicillin-binding proteins and interferes with bacterial cell wall integrity and synthesis. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. ...
Extended-spectrum penicillin
Ureidopenicillins Azlocillin Mezlocillin Piperacillin Carboxypenicillins Ticarcillin (generally in the combination ticarcillin/ ...
বিটা-ল্যাক্টাম অ্যান্টিবায়োটিক - উইকিপিডিয়া
এজলোসিলিন (Azlocillin). *কার্বেনিসিলিন (Carbenicillin). *মেজলোসিলিন (Mezlocillin). *টিকারসিলিন (Ticarcillin). *পাইপেরাসিলিন ( ...
Szerves vegyületek listája - Wikipédia
Ez a szócikk szaklektorálásra, tartalmi javításokra szorul. A felmerült kifogásokat a szócikk vitalapja részletezi. Ha nincs indoklás a vitalapon, bátran távolítsd el a sablont! ...
List of MeSH codes (D03)
... azlocillin MeSH D03.438.260.825.750.050.500 - mezlocillin MeSH D03.438.260.825.750.050.650 - piperacillin MeSH D03.438.260.825. ... azlocillin MeSH D03.605.084.737.750.050.500 - mezlocillin MeSH D03.605.084.737.750.050.650 - piperacillin MeSH D03.605.084.737. ...
Ureidopenicillin
There are three ureidopenicillins in clinical use: Azlocillin Piperacillin Mezlocillin They are mostly ampicillin derivatives ...
List of β-lactam antibiotics
Temocillin Amoxicillin Ampicillin Mecillinam Piperacillin Carbenicillin Ticarcillin Carbenicillin Ticarcillin Azlocillin ...
List of drugs: As-Az
Azlin azlocillin (INN) Azmacort Azo Gantanol Azo Gantrisin Azolid azolimine (INN) Azopt azosemide (INN) azotomycin (INN) ...
Penicillin
Carbenicillin Ticarcillin Temocillin Mezlocillin Piperacillin Azlocillin Clavulanic acid Sulbactam Tazobactam The term " ...
ATC code J01
J01CA04 Amoxicillin J01CA05 Carindacillin J01CA06 Bacampicillin J01CA07 Epicillin J01CA08 Pivmecillinam J01CA09 Azlocillin ...
Timeline of antibiotics
... azlocillin 1977 - cefadroxil 1977 - cefamandole 1977 - cefoxitin 1977 - cefuroxime 1977 - mezlocillin 1977 - pivmecillinam 1979 ...
Penicillin
Azlocillin. β-lactamase inhibitors. *Clavulanic acid. *Sulbactam. *Tazobactam. Pharmacology. Penicillin inhibits activity of ...
Azlocillin
... has been identified as a potential candidate against Lyme disease. Azlocillin is considered a broad spectrum ... Azlocillin is an acylampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy ... Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of ... 0.03 μg/mL - 2 μg/mL Pseudomonas aeruginosa 4 μg/mL - 6.25 μg/mL An interesting alternative synthesis of azlocillin involves ...
Stampa:Penicillin
ureidopenicillins: Azlocillin • Piperacillin • Mezlocillin. other: Mecillinam (Pivmecillinam) • Sulbenicillin. Narrow sp.. β- ...
Azlocillin - Wikipedia
Azlocillin has been identified as a potential candidate against Lyme disease. Azlocillin is considered a broad spectrum ... Azlocillin is an acylampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy ... Azlocillin is similar to mezlocillin and piperacillin. It demonstrates antibacterial activity against a broad spectrum of ... 0.03 μg/mL - 2 μg/mL Pseudomonas aeruginosa 4 μg/mL - 6.25 μg/mL An interesting alternative synthesis of azlocillin involves ...
Azlocillin - Substance Information - ECHA
Azlocillin sodium | definition of azlocillin sodium by Medical dictionary
... azlocillin sodium explanation free. What is azlocillin sodium? Meaning of azlocillin sodium medical term. What does azlocillin ... Looking for online definition of azlocillin sodium in the Medical Dictionary? ... azlocillin sodium. azlocillin sodium. [az′lōsil′in] a semisynthetic penicillin antibiotic. indications It is prescribed for ... Azlocillin sodium , definition of azlocillin sodium by Medical dictionary https://medical-dictionary.thefreedictionary.com/ ...
Azlocillin and Mezlocillin: New Ureido Penicillins | Antimicrobial Agents and Chemotherapy
Azlocillin and Mezlocillin: New Ureido Penicillins Message Subject (Your Name) has forwarded a page to you from Antimicrobial ... Azlocillin and mezlocillin were less active than cefazolin against β-lactamase-producing E. coli and Klebsiella strains but ... Azlocillin and Mezlocillin: New Ureido Penicillins. Kwung P. Fu, Harold C. Neu ... The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of ...
Azlocillin use in dogs | Vetlexicon Canis from Vetlexicon | Definitive Veterinary Intelligence
Azlocillin - A-Z Medication
Azlocillin is a drug used to treatment infections as a result of Pseudomonas aeruginosa, Escherichia coli, and Haemophilus ... Earlier than utilizing Azlocillin, inform your physician and pharmacist:. *In case you are allergic to Azlocillin or different ... Whats Azlocillin used for?. Azlocillin is a drug used to treatment infections as a result of Pseudomonas aeruginosa, ... Is Azlocillin secure for pregnant or breastfeeding ladies?. There isnt any ample analysis on the dangers of utilizing this ...
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Potential treatment for Lyme disease kills bacteria that may cause lingering symptoms, study finds | News Center | Stanford...
... azlocillin, an antibiotic approved by the Food and Drug Administration, eliminated the bacteria that causes Lyme disease. ... Azlocillin comes out on top. The drug, which is not on the market, was tested in mouse models of Lyme disease at seven-day, 14- ... For the first time, azlocillin was also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, ... In this most recent study, azlocillin, one of the top-20 contenders, was shown to eclipse a total of 7,450 compounds because it ...
Multicenter, randomized trial of ciprofloxacin plus azlocillin versus ceftrazidime plus amikacin for empiric treatment of...
N2 - In a multicenter, randomized clinical trial, the efficacy of ciprofloxacin plus azlocillin was compared with that of a ... AB - In a multicenter, randomized clinical trial, the efficacy of ciprofloxacin plus azlocillin was compared with that of a ... In a multicenter, randomized clinical trial, the efficacy of ciprofloxacin plus azlocillin was compared with that of a standard ... Our data suggest that the combination of ciprofloxacin and azlocillin is an effective alternative to ceftazidime and amikacin ...
Azlocillin-natrium vir inspuiting, China Azlocillin-natrium vir inspuitingvervaardigers, verskaffers, fabriek - NINGBO FEIYUE...
Bupropion (Oral Route) Side Effects - Mayo Clinic
Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines that affect the CNS with bupropion may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Bupropion may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. Make sure the doctor knows if you have trouble sleeping, get upset ...
Aplenzin Advanced Patient Information - Drugs.com
Bupropion (Oral Route) Before Using - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Category:Penicillin antibiotics - Wikimedia Commons
penicilina (es); Penisillín (is); Penisilin (ms); Penicillin (en-gb); پنسلين (ps); Пеницилин (bg); پنسلین (pnb); پنسلین (ur); Benseliin (so); Penicilín (sk); Penicillina (oc); 青黴素 (zh-hant); Penicilino (io); Penicilline (gsw); 페니실린 (ko); পেনিচিলিন (as); penicilino (eo); пеницилин (mk); Penicilin (bs); Penicilina (an); পেনিসিলিন (bn); pénicilline (fr); Penisilin (jv); Penicilin (hr); پینی سیلین (lrc); פעניצילין (yi); पेनिसिलिन (mr); penicillin (vi); Penicilīni (lv); Penisillien (af); пеницилин (sr); penicilin (cs); Penicilina (pt-br); Penicillin (sco); Пенициллин (mn); penicillin (nn); penicillin (nb); Pénisilin (su); πενικιλίνη (el); Penicillin (fo); ಪೆನ್ಸಿಲಿನ್ (kn); پێنیسیلین (ckb); penicillin (en); بنسلين (ar); Penisilin (br); Пенициллин (kk); ပင်နီဆီလင် (my); 盤尼西林 ...
Category:Carboxylic acids - Wikimedia Commons
ácido carboxílico (es); Карбон қышқылдары (kk-kz); Asid karboksilik (ms); كاربون قىشقىلدارى (kk-cn); Карбоксилна киселина (bg); کاربوکسلک تیزاب (pnb); 羧酸 (zh-hk); Karboxylová kyselina (sk); карбонові кислоти (uk); 羧酸 (zh-hant); 羧酸 (zh-cn); 카복실산 (ko); Carboxylsýra (fo); karboksilata acido (eo); Карбоксилна киселина (mk); Karboksilne kiseline (bs); কার্বক্সিলিক অ্যাসিড (bn); acide carboxylique (fr); Karboksilne kiseline (hr); axit cacboxylic (vi); كاربون قىشقىلدارى (kk-arab); Karbon qışqıldarı (kk-latn); Karboksielsuur (af); карбоксилна киселина (sr); 羧酸 (zh-sg); Карбон қышқылдары (kk-cyrl); karboksylsyre (nn); karboksylsyre (nb); Asam karboksilat (su); 羧酸 (lzh); ترشی کاربۆکسیلی (ckb); carboxylic acid (en); حمض كربوكسيلي (ar); 羧酸 (yue); ...
Beta-lactamase lability and inducer power of newer beta-lactam antibiotics in relation to their activity against beta-lactamase...
... and azlocillin with the chromosomal beta-lactamase of Pseudomonas aeruginosa were compared. Imipenem was hydrolyzed very slowly ... Azlocillin, cefotaxime, and ceftriaxone were labile to hydrolysis (kcat, 12-297/min) but induced poorly. Consequently their ... The interactions of imipenem, carbenicillin, cefotaxime, ceftriaxone, and azlocillin with the chromosomal beta-lactamase of ...
Antibiotic Therapy for Early Onset Neonatal Sepsis - Full Text View - ClinicalTrials.gov
Patent US8883213 - Ion exchange resin treated to control swelling - Google Patents
... azlocillin, bacampicillin, cefamandole, cefonicid, cefotaxime, cefotetan, cefoxitin, ceftriaxone, mezlocillin and piperacillin ... azlocillin, bacampicillin, cefamandole, cefonicid, cefotaxime, cefotetan, cefoxitin, ceftriaxone, mezlocillin, piperacillin, ... azlocillin, bacampicillin, cefamandole, cefonicid, cefotaxime, cefotetan, cefoxitin, ceftriaxone, mezlocillin, piperacillin, ... azlocillin, bacampicillin, cefamandole, cefonicid, cefotaxime, cefotetan, cefoxitin, ceftriaxone, mezlocillin, piperacillin, ...
Abbreviations and Conventions | Journal of Clinical Microbiology
Statistical analysis of data is a crucial component of scientific publication. Authors who are unsure of proper statistical analysis should have their manuscripts checked by a qualified statistician.. The following is a list of important items that must be considered before manuscript submission. Deficiencies in any of these areas may delay review and/or publication.. (i) The same reference (gold) standard should be used for all samples for a given analyte. That reference standard might include more than one test, but it should be used and interpreted consistently for all samples. The reference standard should not include results from the test that is under study.. (ii) Do not use sensitivity or specificity to describe results which compare a new test to a non-reference standard. Use the terms positive percent agreement and negative percent agreement for these results, as recommended by the FDA guidance document Statistical Guidance on Reporting Results from Studies Evaluating ...
Sodium Citrate Factory - Sodium Citrate Factory Suppliers, Buyers, Wholesalers and Manufacturers - ecplaza.net
MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis | Scientific...
Antifection<...
Penicillin
ALL PHARM 2 Flashcards
Tetracycline, Demeclocycline. Passive diffusion so broad. ALL bac + protoza. Absorption is prevented by *(Ca, Mg, Fe2+, Al3+)- dairy, antiacids, supplements. Renal and bile clearance. MOA: 30S A site ( inhibits elongation). Doxycycline more lipid soluble so DOC: Vibrio, Spirochete(rickettsia, borrelia) , Mycoplasma, Chlamydiae, Brucella (w/ rifampin). Mino is very water soluble in tears, saliva= asymptomatic meningococcal carriers, Doxy is lipid and not cleared by renal. TCA resistance: pumps increasing efflux, change in ribosome binding site, inactivates enzyme. Adverse: ^^ clostridium, *bone and teeth(enamel hypolasia or permanent tooth discoloration,photosensitivity**, Demeclocycline (ADH receptor blocker used in SIADH, so never used as ATX) ** Quinolones, Sulfonamides (rash due to sun) ...
Antimycotic | definition of antimycotic by Medical dictionary
Penicillin-binding protein 1A - DrugBank
An Iodide-Yellow Fluorescent Protein-Gap Junction-Intercellular Communication Assay | Protocol
Difloxacin - Wikipedia
Piperacillin4
- Azlocillin is similar to mezlocillin and piperacillin. (wikipedia.org)
- Voigt R, Schröder S, Peiker G. Pharmacokinetic studies of azlocillin and piperacillin during late pregnancy. (janusinfo.se)
- com)-- Bioo Scientific's MaxSignal[R] Beta-Lactam ELISA Test Kit has been validated for the screening of a wide range of beta-lactam antibiotics including ampicillin, penicillin G, amoxicillin, azlocillin, piperacillin, nafcillin, cloxacillin, oxacillin, cefoperazone, ceftiofur and other beta-lactams in a number of food matrices. (thefreedictionary.com)
- Examples of this class include carboxypenicillins (carbenicillin, its acid-stable indanyl ester, and ticarcillin), ureido-penicillins (azlocillin and mezlocillin), and piperazine penicillins (piperacillin). (merckvetmanual.com)
Mezlocillin4
- The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known β-lactam antibiotics. (asm.org)
- Azlocillin was more active against Pseudomonas than was ticarcillin, carbenicillin, or mezlocillin. (asm.org)
- Azlocillin and mezlocillin were less active than cefazolin against β-lactamase-producing E. coli and Klebsiella strains but more active than cefazolin against Enterobacter , indole-positive Proteus, Acinetobacter, Citrobacter , and Serratia strains. (asm.org)
- Use Pipercillin, ticarcillin, azlocillin mezlocillin for? (brainscape.com)
Carbenicillin5
- The interactions of imipenem, carbenicillin, cefotaxime, ceftriaxone, and azlocillin with the chromosomal beta-lactamase of Pseudomonas aeruginosa were compared. (nih.gov)
- Three-hundred and seventy-two of the isolates were resistant, or had reduced susceptibility, to some or all of azlocillin, carbenicillin, ceftazidime, imipenem and meropenem, and the mechanisms underlying their behaviour were examined. (nih.gov)
- Those with PSE types were highly resistant to azlocillin and carbenicillin whereas those with OXA enzymes were less resistant to these penicillins. (nih.gov)
- Chromosomal beta-lactamase derepression was demonstrated in 54 isolates, most of which were resistant to ceftazidime and azlocillin although susceptible to carbenicillin and carbapenems. (nih.gov)
- For example, in P. aeruginosa inactivation of mexA decreases the MICs of ceftriaxone, cefoperazone, azlocillin, and carbenicillin by a factor of 8 to 128 ( 17 ), and in E. coli the deletion of acrAB decreases the MICs of ampicillin and benzylpenicillin by a factor of 2 to 4 ( 19 ). (asm.org)
Provides evidence that the drug azlocillin2
- A new Stanford Medicine study in lab dishes and mice provides evidence that the drug azlocillin completely kills off the disease-causing bacteria Borrelia burgdorferi at the onset of the illness. (stanford.edu)
- A study provides evidence that the drug azlocillin eliminates the bacteria that cause Lyme disease at the onset of infection in lab mice and cultures. (stanford.edu)
Penicillins1
- Azlocillin is an acylampicillin antibiotic with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. (wikipedia.org)
Cefotaxime5
- Azlocillin, cefotaxime, and ceftriaxone were labile to hydrolysis (kcat, 12-297/min) but induced poorly. (nih.gov)
- In order to identify effective drug molecules that kill drug-tolerant borrelia we have tested two antibiotics, azlocillin and cefotaxime that were identified by us earlier. (stanford.edu)
- The in vitro efficacy studies of azlocillin and cefotaxime on drug-tolerant persisters were done by semisolid plating method. (stanford.edu)
- Our results also demonstrate that azlocillin and cefotaxime can effectively kill in vitro doxycycline-tolerant B. burgdorferi. (stanford.edu)
- Cefotaxime inhibits cephaloridine and azlocillin decomposition by Enterobacteriaceae . (springer.com)
Sodium salt1
- Methicillin https://scopeblog.stanford.edu/2020/03/30/lyme-disease-bacteria-eradicated-by-new-drug-in-early-tests/ "Azlocillin sodium salt Susceptibility and Minimum Inhibitory and Concentration (MIC) Data" (PDF). (wikipedia.org)
Antibiotic2
- Azlocillin is considered a broad spectrum antibiotic and can be used against a number of Gram positive and Gram negative bacteria. (wikipedia.org)
- Screening thousands of drugs, Stanford scientists determined that in mice, azlocillin, an antibiotic approved by the Food and Drug Administration, eliminated the bacteria that causes Lyme disease. (stanford.edu)
Pseudomonas3
- 0.03 μg/mL - 2 μg/mL Pseudomonas aeruginosa 4 μg/mL - 6.25 μg/mL An interesting alternative synthesis of azlocillin involves activation of the substituted phenylglycine analogue 1 with 1,3-dimethyl-2-chloro-1-imidazolinium chloride (2) and then condensation with 6-APA. (wikipedia.org)
- At a concentration of 25 μg/ml, azlocillin inhibited 74% of Enterobacter , 97% of Proteus mirabilis , 64% of Citrobacter , 91% of Pseudomonas aeruginosa , and 82% of Bacteroides strains tested. (asm.org)
- Azlocillin is a drug used to treatment infections as a result of Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. (benefits-of.com)
Gentamicin1
- Gentamicin Gentamicin inactivates azlocillin if mixed in the same syringe. (vetstream.com)
Ceftazidime1
- Our data suggest that the combination of ciprofloxacin and azlocillin is an effective alternative to ceftazidime and amikacin for the initial empiric therapy of febrile neutropenic patients, is generally well tolerated, and avoids the oto- and nephrotoxicity associated with aminoglycoside use. (northwestern.edu)
Probenecid2
- Probenecid reduces the excretion of azlocillin. (vetstream.com)
- Azlocillin, cimetidine and probenecid increase blood levels of difloxacin. (wikipedia.org)
Amikacin1
- In a multicenter, randomized clinical trial, the efficacy of ciprofloxacin plus azlocillin was compared with that of a standard regiment of cerftazidime plus amikacin for the initial empiric treatment of fever in neutropenic cancer patients. (northwestern.edu)
Completely kills1
- We found that azlocillin completely kills late log phase and 7-10 days old stationary phase B. burgdorferi. (stanford.edu)
Lyme4
- Azlocillin has been identified as a potential candidate against Lyme disease. (wikipedia.org)
- For the first time, azlocillin was also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, indicating that it may work as a therapy for lingering symptoms of Lyme disease. (stanford.edu)
- Yeah seems Facebook Groups way ahead of ball game, hope everyone subscribes to Beating Bartonella, along with Disulfiram or Azlocillin for Lyme Support Group, and Babesia Budies. (healingwell.com)
- New research conducted by a Stanford Medicine study in 2020 also shows great promise for Azlocillin, a drug which is not on the market yet, but was tested in mouse models of Lyme disease at 7-day, 14-day, and 21-day intervals and was found to eliminate the infection. (pacificcollege.edu)
Borrelia1
- Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31. (stanford.edu)
Earlier1
- What should be recognized earlier than utilizing Azlocillin? (benefits-of.com)
Study1
- In this most recent study, azlocillin, one of the top-20 contenders, was shown to eclipse a total of 7,450 compounds because it is more effective in killing B. burgdorferi and causes fewer side effects. (stanford.edu)
Therapy1
- 5.Dijkmans BA, Van Der Meer JW, Boekhout-Mussert MJ, Zaal-De Jong M, Mattie H. Prolonged bleeding time during azlocillin therapy. (webmd.com)
Effects1
- What negative effects would possibly happen as a result of Azlocillin? (benefits-of.com)