Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
ACETIC ACID or acetic acid esters substituted with one or more CHLORINE atoms.
Derivatives of benzene in which one or more hydrogen atoms on the benzene ring are replaced by bromine atoms.
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.
Chemical bond cleavage reactions resulting from absorption of radiant energy.
An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.
Inorganic or organic compounds derived from phosphine (PH3) by the replacement of H atoms. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
Carbonic acid (H2C03). The hypothetical acid of carbon dioxide and water. It exists only in the form of its salts (carbonates), acid salts (hydrogen carbonates), amines (carbamic acid), and acid chlorides (carbonyl chloride). (From Grant & Hackh's Chemical Dictionary, 5th ed)
Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Organic compounds composed exclusively of carbon and hydrogen where no carbon atoms join to form a ring structure.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Isomeric forms and derivatives of PROPANOL (C3H7OH).
The geographic area of the northwestern region of the United States. The states usually included in this region are Idaho, Montana, Oregon, Washington, and Wyoming.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
A genus of fungi of the family Agaricaceae, order Agaricales; most species are poisonous.
Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.
The study of plant lore and agricultural customs of a people. In the fields of ETHNOMEDICINE and ETHNOPHARMACOLOGY, the emphasis is on traditional medicine and the existence and medicinal uses of PLANTS and PLANT EXTRACTS and their constituents, both historically and in modern times.
Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These peptides are important in the study of transcription. Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The fruiting 'heads' or 'caps' of FUNGI, which as a food item are familiarly known as MUSHROOMS, that contain the FUNGAL SPORES.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.
Individuals enrolled in a school or formal educational program.
Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.
Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION.
Prospective patient listings for appointments or treatments.
Protein components of the CRISPR-CAS SYSTEMS for anti-viral defense in ARCHAEA and BACTERIA. These are proteins that carry out a variety of functions during the creation and expansion of the CRISPR ARRAYS, the capture of new CRISPR SPACERS, biogenesis of SMALL INTERFERING RNA (CRISPR or crRNAs), and the targeting and silencing of invading viruses and plasmids. They include DNA HELICASES; RNA-BINDING PROTEINS; ENDONUCLEASES; and RNA and DNA POLYMERASES.
A nucleocytoplasmic transport protein that binds to ALPHA KARYOPHERINS and RAN GTP BINDING PROTEIN inside the CELL NUCLEUS and participates in their export into CYTOPLASM. It is also associated with the regulation of APOPTOSIS and microtubule assembly.
A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
Organic compounds with the general formula R-NCS.
The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.
Chemical and physical transformation of the biogenic elements from their nucleosynthesis in stars to their incorporation and subsequent modification in planetary bodies and terrestrial biochemistry. It includes the mechanism of incorporation of biogenic elements into complex molecules and molecular systems, leading up to the origin of life.

Analysis of the membrane-interacting domains of myelin basic protein by hydrophobic photolabeling. (1/145)

Myelin basic protein is a water soluble membrane protein which interacts with acidic lipids through some type of hydrophobic interaction in addition to electrostatic interactions. Here we show that it can be labeled from within the lipid bilayer when bound to acidic lipids with the hydrophobic photolabel 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine (TID) and by two lipid photolabels. The latter included one with the reactive group near the apolar/polar interface and one with the reactive group linked to an acyl chain to position it deeper in the bilayer. The regions of the protein which interact hydrophobically with lipid to the greatest extent were determined by cleaving the TID-labeled myelin basic protein (MBP) with cathepsin D into peptides 1-43, 44-89, and 90-170. All three peptides from lipid-bound protein were labeled much more than peptides from the protein labeled in solution. However, the peptide labeling pattern was similar for both environments. The two peptides in the N-terminal half were labeled similarly and about twice as much as the C-terminal peptide indicating that the N-terminal half interacts hydrophobically with lipid more than the C-terminal half. MBP can be modified post-translationally in vivo, including by deamidation, which may alter its interactions with lipid. However, deamidation had no effect on the TID labeling of MBP or on the labeling pattern of the cathepsin D peptides. The site of deamidation has been reported to be in the C-terminal half, and its lack of effect on hydrophobic interactions of MBP with lipid are consistent with the conclusion that the N-terminal half interacts hydrophobically more than the C-terminal half. Since other studies of the interaction of isolated N-terminal and C-terminal peptides with lipid also indicate that the N-terminal half interacts hydrophobically with lipid more than the C-terminal half, these results from photolabeling of the intact protein suggest that the N-terminal half of the intact protein interacts with lipid in a similar way as the isolated peptide. The similar behavior of the intact protein to that of its isolated peptides suggests that when the purified protein binds to acidic lipids, it is in a conformation which allows both halves of the protein to interact independently with the lipid bilayer. That is, it does not form a hydrophobic domain made up from different parts of the protein.  (+info)

NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone. (2/145)

The proton-translocating NADH-quinone oxidoreductase (EC 1.6.99.3) is the largest and least understood enzyme complex of the respiratory chain. The mammalian mitochondrial enzyme (also called complex I) contains more than 40 subunits, whereas its structurally simpler bacterial counterpart (NDH-1) in Paracoccus denitrificans and Thermus thermophilus HB-8 consists of 14 subunits. A major unsolved question is the location and mechanism of the terminal electron transfer step from iron-sulfur cluster N2 to quinone. Potent inhibitors acting at this key region are candidate photoaffinity probes to dissect NADH-quinone oxidoreductases. Complex I and NDH-1 are very sensitive to inhibition by a variety of structurally diverse toxicants, including rotenone, piericidin A, bullatacin, and pyridaben. We designed (trifluoromethyl)diazirinyl[3H]pyridaben ([3H]TDP) as our photoaffinity ligand because it combines outstanding inhibitor potency, a suitable photoreactive group, and tritium at high specific activity. Photoaffinity labeling of mitochondrial electron transport particles was specific and saturable. Isolation, protein sequencing, and immunoprecipitation identified the high-affinity specifically labeled 23-kDa subunit as PSST of complex I. Immunoprecipitation of labeled membranes of P. denitrificans and T. thermophilus established photoaffinity labeling of the equivalent bacterial NQO6. Competitive binding and enzyme inhibition studies showed that photoaffinity labeling of the specific high-affinity binding site of PSST is exceptionally sensitive to each of the high-potency inhibitors mentioned above. These findings establish that the homologous PSST of mitochondria and NQO6 of bacteria have a conserved inhibitor-binding site and that this subunit plays a key role in electron transfer by functionally coupling iron-sulfur cluster N2 to quinone.  (+info)

Inhibition of DNA replicon initiation by 4-nitroquinoline 1-oxide, adriamycin, and ethyleneimine. (3/145)

The effects of three widely differing chemical carcinogens, 4-nitroquinoline 1-oxide, Adriamycin, and ethyleneimine, on DNA replication were studied by pulse labeling of DNA with [3H]thymidine and sedimentation analysis with alkaline sucrose gradients. At doses that reduced the rate of DNA synthesis to 30 to 60% of control values, only ethyleneimine produced damage that resulted in lower molecular weights of parental DNA. All three chemicals inhibited replicon initiation, but to differing extents. Inhibition of replicon initiation was the first clearly identified effect of 4-nitroquinoline 1-oxide and was the main cause of inhibition of DNA synthesis. Ethyleneimine caused severe inhibition of replicon initiation, but blocks to chain elongation also contributed significantly to the inhibition of overall DNA synthesis. Adriamycin affected replicon initiation to a small but significant extent; the primary cause of inhibition of DNA synthesis by this drug was a slowing of the rate of chain elongation. These results indicate that inhibition of replicon initiation is an important mechanism for the action of DNA-damaging agents in mammalian cells and strengthen the concept that control of DNA replication depends on the structural integrity of a chromosomal subunit that consists of several replicons.  (+info)

The membrane binding domains of prostaglandin endoperoxide H synthases 1 and 2. Peptide mapping and mutational analysis. (4/145)

Prostaglandin endoperoxide H synthases 1 and 2 (PGHS-1 and -2) are the major targets of nonsteroidal anti-inflammatory drugs. Both isozymes are integral membrane proteins but lack transmembrane domains. X-ray crystallographic studies have led to the hypothesis that PGHS-1 and -2 associate with only one face of the membrane bilayer through a novel, monotopic membrane binding domain (MBD) that is comprised of four short, consecutive, amphipathic alpha-helices (helices A-D) that include residues 74-122 in ovine PGHS-1 (oPGHS-1) and residues 59-108 in human PGHS-2 (hPGHS-2). Previous biochemical studies from our laboratory showed that the MBD of oPGHS-1 lies somewhere between amino acids 25 and 166. In studies reported here, membrane-associated forms of oPGHS-1 and hPGHS-2 were labeled using the hydrophobic, photoactivable reagent 3-trifluoro-3-(m-[(125)I]iodophenyl)diazirine, isolated, and cleaved with AspN and/or GluC, and the photolabeled peptides were sequenced. The results establish that the MBDs of oPGHS-1 and hPGHS-2 reside within residues 74-140 and 59-111, respectively, and thus provide direct provide biochemical support for the hypothesis that PGHS-1 and -2 do associate with membranes through a monotopic MBD. We also prepared HelA, HelB, and HelC mutants of oPGHS-1, in which, for each helix, three or four hydrophobic residues expected to protrude into the membrane were replaced with small, neutral residues. When expressed in COS-1 cells, HelA and HelC mutants exhibited little or no catalytic activity and were present, at least in part, as misfolded aggregates. The HelB mutant retained about 20% of the cyclooxygenase activity of native oPGHS-1 and partitioned in subcellular fractions like native oPGHS-1; however, the HelB mutant exhibited an extra site of N-glycosylation at Asn(104). When this glycosylation site was eliminated (HelB/N104Q mutation), the mutant lacked cyclooxygenase activity. Thus, our mutational analyses indicate that the amphipathic character of each helix is important for the assembly and folding of oPGHS-1 to a cyclooxygenase active form.  (+info)

Examining the noncompetitive antagonist-binding site in the ion channel of the nicotinic acetylcholine receptor in the resting state. (5/145)

3-Trifluoromethyl-3-(m-[(125)I]iodophenyl)diazirine ([(125)I]TID) has been shown to be a potent noncompetitive antagonist (NCA) of the nicotinic acetylcholine receptor (AChR). Amino acids that contribute to the binding site for [(125)I]TID in the ion channel have been identified in both the resting and desensitized state of the AChR (White, B.H., and Cohen, J.B. (1992) J. Biol. Chem. 267, 15770-15783). To characterize further the structure of the NCA-binding site in the resting state channel, we have employed structural analogs of TID. The TID analogs were assessed by the following: 1) their ability to inhibit [(125)I]TID photoincorporation into the resting state channel; 2) the pattern, agonist sensitivity, and NCA inhibition of [(125)I]TID analog photoincorporation into AChR subunits. The addition of a primary alcohol group to TID has no demonstrable effect on the interaction of the compound with the resting state channel. However, conversion of the alcohol function to acetate, isobutyl acetate (TIDBIBA), or to trimethyl acetate leads to rightward shifts in the concentration-response curves for inhibition of [(125)I]TID photoincorporation into the AChR channel and a progressive reduction in the agonist sensitivity of [(125)I]TID analog photoincorporation into AChR subunits. Inhibition of [(125)I]TID analog photoincorporation by NCAs (e.g. tetracaine) as well as identification of the sites of [(125)I]TIDBIBA photoincorporation in the deltaM2 segment indicate a common binding locus for each TID analog. We conclude that relatively small additions to TID progressively reduce its ability to interact with the NCA site in the resting state channel. A model of the NCA site and resting state channel is presented.  (+info)

Assembly of archaeal signal recognition particle from recombinant components. (6/145)

Signal recognition particle (SRP) takes part in protein targeting and secretion in all organisms. Searches for components of archaeal SRP in primary databases and completed genomes indicated that archaea possess only homologs of SRP RNA, and proteins SRP19 and SRP54. A recombinant SRP was assembled from cloned, expressed and purified components of the hyperthermophilic archaeon Archaeoglobus fulgidus. Recombinant Af-SRP54 associated with the signal peptide of bovine pre-prolactin translated in vitro. As in mammalian SRP, Af-SRP54 binding to Af-SRP RNA required protein Af-SRP19, although notable amounts bound in absence of Af-SRP19. Archaeoglobus fulgidus SRP proteins also bound to full-length SRP RNA of the archaeon Methanococcus jannaschii, to eukaryotic human SRP RNA, and to truncated versions which corresponded to the large domain of SRP. Dependence on SRP19 was most pronounced with components from the same species. Reconstitutions with heterologous components revealed a significant potential of human SRP proteins to bind to archaeal SRP RNAs. Surprisingly, M.jannaschii SRP RNA bound to human SRP54M quantitatively in the absence of SRP19. This is the first report of reconstitution of an archaeal SRP from recombinantly expressed purified components. The results highlight structural and functional conservation of SRP assembly between archaea and eucarya.  (+info)

Molecular models of the structural arrangement of subunits and the mechanism of proton translocation in the membrane domain of F(1)F(0) ATP synthase. (7/145)

Subunit c of the proton-transporting ATP synthase of Escherichia coli forms an oligomeric complex in the membrane domain that functions in transmembrane proton conduction. The arrangement of subunit c monomers in this oligomeric complex was studied by scanning mutagenesis. On the basis of these studies and structural information on subunit c, different molecular models for the potential arrangement of monomers in the c-oligomer are discussed. Intersubunit contacts in the F(0) domain that have been analysed in the past by chemical modification and mutagenesis studies are summarised. Transient contacts of the c-oligomer with subunit a might play a crucial role in the mechanism of proton translocation. Schematic models presented by several authors that interpret proton transport in the F(0) domain by a relative rotation of the c-subunit oligomer against subunit a are reviewed against the background of the molecular models of the oligomer.  (+info)

A conformational intermediate between the resting and desensitized states of the nicotinic acetylcholine receptor. (8/145)

The structural changes induced in the nicotinic acetylcholine receptor by two noncompetitive channel blockers, proadifen and phencyclidine, have been studied by infrared difference spectroscopy and using the conformationally sensitive photoreactive noncompetitive antagonist 3-(trifluoromethyl)-3-m-([(125)I]iodophenyl)diazirine. Simultaneous binding of proadifen to both the ion channel pore and neurotransmitter sites leads to the loss of positive markers near 1663, 1655, 1547, 1430, and 1059 cm(-)(1) in carbamylcholine difference spectra, suggesting the stabilization of a desensitized conformation. In contrast, only the positive markers near 1663 and 1059 cm(-)(1) are maximally affected by the binding of either blocker to the ion channel pore suggesting that the conformationally sensitive residues vibrating at these two frequencies are stabilized in a desensitized-like conformation, whereas those vibrating near 1655 and 1430 cm(-)(1) remain in a resting-like state. The vibrations at 1547 cm(-)(1) are coupled to those at both 1663 and 1655 cm(-)(1) and thus exhibit an intermediate pattern of band intensity change. The formation of a structural intermediate between the resting and desensitized states in the presence of phencyclidine is further supported by the pattern of 3-(trifluoromethyl)-3-m-([(125)I]iodophenyl)diazirine photoincorporation. In the presence of phencyclidine, the subunit labeling pattern is distinct from that observed in either the resting or desensitized conformations; specifically, there is a concentration-dependent increase in the extent of photoincorporation into the delta-subunit. Our data show that domains of the nicotinic acetylcholine receptor interconvert between the resting and desensitized states independently of each other and suggest a revised model of channel blocker action that involves both low and high affinity agonist binding conformational intermediates.  (+info)

Read about the chemical and physical properties of 5-(2-Methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-thiophene-2-carboxylic acid [(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-amide. Get 5-(2-Methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-thiophene-2-carboxylic acid [(1R,2R)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-amide molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
2-TRIFLUOROMETHYL-9H-CARBAZOLE (CAS 2285-35-0) Market Research Report 2018 aims at providing comprehensive data on 2-trifluoromethyl-9h-carbazole market
TY - JOUR. T1 - Aziridinylbenzoquinone (AZQ) in the treatment of recurrent pediatric brain and other malignant solid tumors - A Pediatric Oncology Group phase II study. AU - Castleberry, R. P.. AU - Ragab, A. H.. AU - Steuber, C. P.. AU - Kamen, B.. AU - Toledano, S.. AU - Starling, K.. AU - Norris, D.. AU - Burger, P.. AU - Krischer, J. P.. PY - 1990/11. Y1 - 1990/11. N2 - To assess the response rates and toxicity of AZQ in children with recurrent brain and other malignant solid tumors, a phase II study was implemented by the Pediatric Oncology Group. Eligible patients received AZQ 18 mg/M2/week i.v. for 4 doses followed by a 2 week rest period. Each dose was given over four hours (1/3 over the initial 20 minutes). After the first year, the dosage was reduced to 13 mg/M2 due to myelotoxicity resulting in treatment delays. No objective responses were observed in 73 evaluable children with various noncentral nervous system tumors. Of the 91 patients with brain tumors, there were 4 CRs and 2 PRs ...
Learn more about 1-methyl-5-trifluoromethyl-1h-benzimidazol-2-amine-hydrobromide. We enable science by offering product choice, services, process excellence and our people make it happen.
5-Trifluoromethyl-1H-indole-2-carboxylic acid 496946-78-2 Precursor and Downstream products, 5-Trifluoromethyl-1H-indole-2-carboxylic acid Precursor products, 5-Trifluoromethyl-1H-indole-2-carboxylic acid Downstream products ect.
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The development and implementation of a scalable process for the manufacture of the Toll-like receptor (TLR7) agonist PF-4171455 (1) is described. Initial routes used to synthesise 1 in milligram quantities were unsuitable for large-scale synthesis to provide bulk material. As part of the transfer between Medicinal Chemistry and Research-API, collaboration provided a fit for purpose route for the kilo-scale synthesis of 1. Key aspects of the synthesis included (i) a safe and practical synthesis of a key nitropyridone intermediate 7 over four steps, (ii) a sequential regioselective chlorination to selectively functionalise 7 and (iii) use of a carbamate as a tethered carbonyl group, allowing an efficient regiospecific synthesis of 1.. ...
An enantioselective aza-Friedel-Crafts alkylation reaction of indoles with 1-trifluoromethyl-3,4-dihydro-β-carbolines catalyzed by a chiral spirocyclic phosphoric acid has been realized. This methodology provides a facile route to 1-trifluoromethyl-1-indole-substituted tetrahydro-β-carbolines featuring a CF3 Organic Chemistry Frontiers HOT articles for 2017
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
When using this server please cite the following paper:. Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.. Bioinformatics. 2011 May 18. ...
PubMed journal article Preparation of a poly(ethyleneimine) embedded phenyl stationary phase for mixed-mode liquid chromatograph were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
The BCL-2 family of proteins tightly regulates the delicate balance between life and death. The pore forming Bax is a pro-apoptotic member belonging to this protein family. At the onset of apoptosis, monomeric cytoplasmic Bax translocates to the outer mitochondrial membrane, forms oligomeric pores thereby letting mitochondrial cytochrome c enter the cytosol and initiate the apoptotic cascade. The C-terminal helix 9 is thought to mediate the membrane binding of BAX. A 20-amino acid peptide corresponding to Bax C-terminus (VTIFVAGVLTASLTIWKKMG) and two mutants where the two lysines are replaced with Glu (charge reversal mutant, EE) or Leu (charge neutralization mutant, LL) have been studied to elucidate the pore formation capabilities of Bax C-terminus and the underlying molecular mechanism. Interactions of the wild-type and the two mutant peptides with zwitterionic and anionic phospholipid membranes caused efficient membrane permeabilization, as documented by release of vesicle-entrapped fluorescent
In this tutorial, you have learned how to download and install SQLite tools on your computer. The functioninclude, like the standard functiontemplate, if the value exists,. GOOGLE_CLOUD_PROJECT, the environmental variable used by Application Default Credentials library support to define project ID, is also set to point to the active project in Console. The membrane-embedded domains of integral membrane proteins are structurally quite simple, allowing the use of various prediction methods and biochemical methods to obtain structural information about membrane proteins. For 2x2 tables, significance was determined by 1-tailed Fisher Exact tests. Then, I only want the main. We use Helm and released a Drone plugin to set up CI/CD for a private Helm Repository backed by S3. $\begingroup$ @Betty What I said above was just confusing so lets start over: it does not matter what you call the integration label, because all they are is labels telling you to integrate a function of some variable with respect ...
Human serum albumin (HSA) is a transport protein very abundant in blood and plasma; one of their main functions is to carry endogenous and exogenous agents in the bloodstream.1 Binding of ligands to HSA is a process that can modulate a number of properties of the carried agent. In this work, the photophysical behaviour of 4-trifluoromethyl-1-hydroxy-naphthalene (TFN) 2, 3, 4 encapsulated within HSA is described. Supramolecular binding of TFN to HSA can be followed by the enhancement of the fluorescence emission after addition of increasing amounts of protein (Figure 1A). A complex [email protected] is detected in the absorption spectrum with maxima at ca. 340 nm ...
Torcetrapib ≥98% (HPLC); CAS Number: 262352-17-0; Synonym: (2R,4S)-4-((3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester, CP-529,414, CP-529414; Linear Formula: C26H25F9N2O4; find Sigma-Aldrich-PZ0170 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
This page contains information on the chemical 1-Piperazineethanol, 4-(4-fluoro-3-(trifluoromethyl)phenyl)-alpha-((4-(4-fluoro-3- (trifluoromethyl)phenyl)-1-piperazinyl)methyl)-, phosphate, hydrate (1:2:1) (salt) including: 2 synonyms/identifiers.
Find quality suppliers and manufacturers of 401590-41-8(6-Chloro-3-(trifluoroMethyl)picolinonitrile) for price inquiry. where to buy 401590-41-8(6-Chloro-3-(trifluoroMethyl)picolinonitrile).Also offer free database of 401590-41-8(6-Chloro-3-(trifluoroMethyl)picolinonitrile) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
chemBlink provides information about CAS # 1065103-97-0, 4-Methoxy-2-(trifluoromethyl)pyridine, 4-(Methyloxy)-2-(trifluoromethyl)pyridine, molecular formula: C7H6F3NO.
CHEMVON BIOTECHNOLOGY: We are leading Manufacturer,Supplier & Exporter of [2R-[2α(S*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)- Morpholine,
Page contains details about tris(3,5-bis(trifluoromethyl)benzoato)bismuth(III) film . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
2-Pyridineacetic acid, 4-(trifluoromethyl)-. CAS 1000515-78-5. MDL Number:MFCD09924926. Molecular Formula:C8H6F3NO2. Molecular Weight:C8H6F3NO2.
Benzeneacetic acid, 4-methoxy-3-(trifluoromethyl)-. CAS 1000566-45-9. MDL Number:MFCD09832302. Molecular Formula:C10H9F3O3. Molecular Weight:C10H9F3O3.
Looking for TCI AMERICAS 3-(Trifluoromethyl)Benzenethiol,25g (20DF12)? Graingers got your back. Price:$410.00. Easy ordering & convenient delivery. Log-in or register for your pricing.
While the transport of cell surface proteins is relatively easily studied, visualizing the trafficking of intracellular proteins is...
李位仁(2010/08/01-2012/07/31)。重點一子題2---含嘧啶或亞碳配子或C4對稱氧釩中心四聚體之鎳和銅錯合物進行不對稱共軛加成及碳氫化合物氧合化反應之研究。國科會。(NSC 98-2119-M-003-002-MY3 )。主持人 ...
TY - JOUR. T1 - Ethylcholine mustard aziridinium blocks the axoplasmic transport of acetylcholinesterase in cholinergic nerve fibres of the rat. AU - Kása, P.. AU - Hanin, I.. PY - 1985/7. Y1 - 1985/7. N2 - A cholinotoxin, ethylcholine mustard aziridinium ion, (AF64A) specifically and ireversibly blocks the intraaxonal transport of acetylcholinesterase in the rat. Impairment of the transport of this enzyme in the septo-hippocampal cholinergic fibres and in the sciatic nerve has been studied, using different doses of AF64A. It is demonstrated that the effect on the axonal transport is dose-dependent, but is not related to the mode of drug application. AF64A thus may exert its neurotoxic effects on cholinergic neurons at several target sites of action. In addition to the localized presynaptic mechanisms, it may also be compromising cholinergic function by inhibiting axonal transport in vivo.. AB - A cholinotoxin, ethylcholine mustard aziridinium ion, (AF64A) specifically and ireversibly blocks ...
1. Concise synthesis of enantiopure alfa-trifluoromethyl alanines, diamines and amino alcohols via the Strecker-type reaction, Huguenot, F. ; Brigaud, T. J. Org. Chem. 2006, 71, 7075-7078. 2. Straightforward synthesis of (S)- and (R)-alfa-trifluoromethyl proline from chiral oxazolidines derived from ethyl trifluoropyruvate, Chaume, G., Van Severen, M.-C., Marinkovic, S. ; Brigaud, T. Org. Lett. 2006, 8, 6123-6126. 3. Convenient asymmetric synthesis of beta-trifluoromethyl-beta-amino acid, beta-amino ketones and gama-amino alcohols via Reformatsky and Mannich type reactions from 2-trifluoromethyl-1,3-oxazolidines, Huguenot, F. ; Brigaud, T. J. Org. Chem. 2006, 71, 2159-2162. 4. Chiral 2-trifluoromethyl-4-phenyloxazolidine : A novel highly performing chiral auxiliary for amides alkylation, Tessier, A. ; Pytkowicz, J. ; Brigaud, T. Angew. Chem. Int. Ed. Engl. 2006, 45, 3677-3681. 5. Gram-Scale Preparation of a p-(C-Glucopyranosyl)-L-phenylalanine Derivative by a Negishi Cross-Coupling Reaction, ...
In this contribution we outline polyelectrolyte (PEL) complex (PEC) nanoparticles, prepared by mixing solutions of the low cost PEL components poly(ethyleneimine) (PEI) and poly(acrylic acid) (PAC). It was found, that the size and internal structure of PEI/PAC particles can be regulated by process, media and structural parameters. Especially, mixing order, mixing ratio, PEL concentration, pH and molecular weight, were found to be sensible parameters to regulate the size (diameter) of spherical PEI/PAC nanoparticles, in the range between 80-1,000 nm, in a defined way. Finally, applications of dispersed PEI/PAC particles as additives for the paper making process, as well as for drug delivery, are outlined. PEI/PAC nanoparticles mixed directly on model cellulose film showed a higher adsorption level applying the mixing order 1. PAC 2. PEI compared to 1. PEI 2. PAC. Surface bound PEI/PAC nanoparticles were found to release a model drug compound and to stay immobilized due to the contact with the aqueous
The relative resistance of malignant glioma to chemotherapy makes the identification of new cytotoxic drugs critically important. The use of short-term cultures derived from these tumors to screen drugs at doses that can be attained within human intracranial tumors provides a model system that should be capable of identifying effective drugs suitable for clinical evaluation. The sensitivity of a panel of short-term cultures derived from 22 malignant astrocytoma and four malignant oligodendroglioma was assessed to aziridinylbenzoquinone (AZQ), etoposide and doxorubicin (DOX) using a [(35)S] methione uptake assay. The ID(50) of each culture was compared to the levels of drug which could be achieved in the tumor using standard doses. There was marked heterogeneity between cultures in response to each drug. Whilst there was no evidence that cultures derived from grade III astrocytoma were more sensitive to any of the drugs than cultures derived from grade IV astrocytoma, cultures derived from ...
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The relative pronoun which refers to inanimate things and to animals: The house, which we had seen only from a distance, impressed us even more as we approached. Nce BibMe makes it easy to create citations, build bibliographies and. JOURNAL OF RITUAL STUDIES. Rs pitt.. E Journal of Ritual Studies is an independent, subscriber based, peer review Journal. Owing the Powers of Ten by Charles and Ray Eames, zooming out into the macrocosmos, zooming in into the. Och Wan and Mark Vanderwerf. A ritual is a sequence of activities involving gestures, words, and objects, performed in a sequestered place, and performed according to set sequence. A REVIEW OF THE LITERATURE ON ETHNICITY, NATIONAL IDENTITY AND RELATED MISSIOLOGICAL STUDIES. Oroso, Jon William (2014) Reactive Probes for Manipulating Polyketide Synthases, and Photoreactive Probes for Strained Alkyne Click Chemistry techno manager interview essays sketch of the information omniverse Kas Oosterhuis 2017. Using other peoples research or ideas ...
The mechanism of the antiviral activity of 5-trifluoromethyl-2-deoxyuridine (F3TdR) has been studied in vaccinia virus-infected HeLa cells. When normal virions are used to infect the cells in the presence of the analogue, sucrose gradient sedimentation has shown that the early messenger RNA is normal and associates normally with polyribosomes. However, any late mRNA that may be produced under those conditions has abnormal sedimentation properties and does not associate normally with polyribosomes. When the cells are infected with purified virions containing F3TdR in their DNA, they adsorb to the cells and are uncoated normally. However, early mRNA is not transcribed normally. Studies of viral protein synthesis with polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate suggest that a major virus-induced protein is not synthesized in the presence of F3TdR, and that another protein is formed instead.. ...
The purpose of this study was to evaluate the effects of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3α, 21-dihydroxy-3β-trifluoromethyl-19-nor-5β-pregnan-20-one), on γ-aminobutyric acidA receptors in vitro and to define its anxiolytic-like effects and side effect profile in vivo. Co 2-6749 fully inhibited [35S]t-butylbicyclophosphorothionate binding in rat brain cortical membranes with an IC50 value of 230 nM and in human γ-aminobutyric acidA receptor subunit combinations of α1β2γ2L, α2β2γ2L, α3β2γ2L, α4β3γ2L, α5β2γ2L, and α6β3γ2L receptors (IC50 values of 200, 200, 96, 2300, 210, and 2000 nM). Rats were trained in a Geller-Seifter operant conflict paradigm. Co 2-6749 caused a dose-related increase in punished responding with a minimum effective dose of 1.6 mg/kg, p.o., a wide therapeutic index relative to a decrease in unpunished responding and relative to ataxia, and no tolerance. Additionally, ethanol caused less than a 2-fold shift to the left in the ...
To get a deeper insight into the function of estrogen-related receptors (ERRs) and dissect underlying mechanism in Leydig cells, ERRs (type α, β and γ) were blocked or activated in testes of adult bank voles (Myodes glareolus) which show seasonal changes in the intratesticular sex hormones level. Both actively reproducing animals (long day conditions; LD) and those with regression of the reproductive system (short day conditions; SD) received intraperitoneal injections of selective ERRα antagonist 3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide (XCT 790) or selective ERRβ/ERRγ agonist N-(4-(Diethylaminobenzylidenyl)-N-(4-hydroxybenzoyl)-hydrazine (DY131) (50 μ/kg bw; six doses every other day ...
Еремеев А.В.; Солодин И.В.; Лиепиньш Э.Э.; Костяновский Р.Г. Исследование методов синтеза азиридинов и азиринов на основе этил-beta,beta-бис(трифторметил)акрилата = Investigation of methods for the synthesis of aziridines and azirines on the basis of ethyl-beta,beta-bis(trifluoromethyl) acrilate. Химия гетероцикл.соед. 1984(7), 917-921; Chem.Heterocycl. Comp. (Engl. Ed.). 1984, 20(7), 744-748 ...
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1SJI: Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization.
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If you would like to contact Kingchem, please call us at +1-201-825-9988. We are in the office between 8:30 to 5:00 (eastern USA time) -- or simply fill out the below short form and we will be in touch with you very soon.. ...
However, azirine intermediates have been isolated. The mechanism is postulated to proceed via a nitrene intermediate. ... Gilchrist, T. L. (2001). "Activated 2H-Azirines as Dienophiles and Electrophiles" (PDF). Aldrichimica Acta. 34 (2): 51. ...
3‑Oxazolines are even less common but have been synthesised photochemically[5] and by the ring opening of azirines.[6] These ... Sá, Marcus C. M.; Kascheres, Albert (1996). "Electronically Mediated Selectivity in Ring Opening of 1-Azirines. The 3-X Mode: ...
Alkynes, carbonyl compounds, imines and azirines can also act as dipolarophile. Nitrile ylides react with weak acids like ... by the photochemical ring opening of azirines and by dehydrochlorination of imidoyl chlorides. The latter is the most reliable ...
"3-Phenyl-2H-Azirine-2-carboxaldehyde". Organic Syntheses.; Collective Volume, 6, p. 893. ...
The Neber rearrangement offers an alternative to electrophilic amination through the intermediacy of an azirine. The wide ...
Hassner's group pioneered in methodology for synthesis of small ring heterocycles such as aziridines, azirines, azetines, as ...
Azirines can also be synthesized from the addition product by adding base to eliminate HI, giving a vinyl azide which undergoes ... thermolysis to form an azirine. Further radical modes of reactivity include radical substitutions on weak C-H bonds to form α‐ ...
Added base forms a carbanion which displaces the tosylate group in a nucleophilic displacement to an azirine and added water ...
Certain N-substituted azirines with electron withdrawing groups on both carbons form azomethine ylides in an electrocyclic ...
Iminium ion formation is prohibited in this molecule because the azirine group and the formyl group are said to be orthogonal. ...
The molecular formula C2H3N (molar mass: 41.05 g/mol) may refer to: Acetonitrile (MeCN) Azirine Methyl isocyanide, or ...
2H-Azirines can be considered strained imines and are isolable. 2H-Azirine is most often obtained by the thermolysis of vinyl ... There are two isomers of azirine: 1H-azirine with a carbon-carbon double bond are not stable and rearrange to the tautomeric 2H ... An azirine is an intermediate in the Neber rearrangement. Teresa M. V. D. Pinho e Melo and Antonio M. d'A. Rocha Gonsalves ( ... Photolysis of azirines (under 300 nm) is a very efficient way to generate nitrile ylides. These nitrile ylides are dipolar ...
Azirine. Oxirene. Thiirene 4-Atom Ring Azetidine. Oxetane. Thietane. Azete. Oxete. Thiete ...
2H-Azirines can be considered strained imines and are isolable. 2H-Azirine is most often obtained by the thermolysis of vinyl ... There are two isomers of azirine: 1H-azirine with a carbon-carbon double bond are not stable and rearrange to the tautomeric 2H ... An azirine is an intermediate in the Neber rearrangement. Teresa M. V. D. Pinho e Melo and Antonio M. dA. Rocha Gonsalves ( ... Photolysis of azirines (under 300 nm) is a very efficient way to generate nitrile ylides. These nitrile ylides are dipolar ...
3-amino-2h-azirines in the synthesis of peptides: tetrapeptides with alpha,alpha-disubstituted alpha-amino acids ... The "azirine/oxazolone-method" offers an efficient stra- tegy for the synthesis of peptide-models used for con- formational ... The "azirine/oxazolone-method" offers an efficient stra- tegy for the synthesis of peptide-models used for con- formational ... Sahebi, Mostafa; Wipf, Peter; Heimgartner, Heinz (1989). 3-amino-2h-azirines in the synthesis of peptides: tetrapeptides with ...
3-Amino-2H-azirines. Synthons for alpha,alpha-Disubstituted alpha-Amino Acids in Heterocycle and Peptide Synthesis ... 3-Amino-2H-azirines are ideal synthons for the construction of oligopeptides, cyclic peptides and depsipeptides (peptolides) ... 3-Amino-2H-azirines are ideal synthons for the construction of oligopeptides, cyclic peptides and depsipeptides (peptolides) ... Heimgartner, Heinz (1991). 3-Amino-2H-azirines. Synthons for alpha,alpha-Disubstituted alpha-Amino Acids in Heterocycle and ...
... MULLER F, Mattay J (1991) ... F. MULLER and J. Mattay, "[3+2] CYCLOADDITIONS WITH AZIRINE RADICAL CATIONS - A NEW SYNTHESIS OF N-SUBSTITUTED IMIDAZOLES", ... MULLER F, Mattay J. [3+2] CYCLOADDITIONS WITH AZIRINE RADICAL CATIONS - A NEW SYNTHESIS OF N-SUBSTITUTED IMIDAZOLES. Angewandte ... MULLER, F., and Mattay, J. (1991). [3+2] CYCLOADDITIONS WITH AZIRINE RADICAL CATIONS - A NEW SYNTHESIS OF N-SUBSTITUTED ...
Rearrangement of Azirines via Thermolysis. D. Taber and W. Tian of the University of Delaware have reported on the synthesis of ... via the thermal rearrangement of azirines 16 that are readily available from the ketones 15 (Neber reaction) via the ... Scheme 5 - Indole synthesis via rearrangement of functionalized azirines 16.. IV. N-Methoxyindoles via Alkylative Cycloaddition ...
... of the Reaction of Electron Deficient Olefins with Nitrile Ylides Generated by Laser Flash Photolysis of Substituted Azirines. ... of the Reaction of Electron Deficient Olefins with Nitrile Ylides Generated by Laser Flash Photolysis of Substituted Azirines. ... of the Reaction of Electron Deficient Olefins with Nitrile Ylides Generated by Laser Flash Photolysis of Substituted Azirines. ... of the Reaction of Electron Deficient Olefins with Nitrile Ylides Generated by Laser Flash Photolysis of Substituted Azirines. ...
3‑Oxazolines are even less common but have been synthesised photochemically[5] and by the ring opening of azirines.[6] These ... Sá, Marcus C. M.; Kascheres, Albert (1996). "Electronically Mediated Selectivity in Ring Opening of 1-Azirines. The 3-X Mode: ...
1H-Azirine, dihydro-; Dihydroazirene; Dihydro-1H-azirine; Dimethyleneimine; ENT-50324; Ethyleenimine; Etilenimina; Rcra waste ...
However, azirine intermediates have been isolated. The mechanism is postulated to proceed via a nitrene intermediate. ... Gilchrist, T. L. (2001). "Activated 2H-Azirines as Dienophiles and Electrophiles" (PDF). Aldrichimica Acta. 34 (2): 51. ...
The Chemistry of Heterocyclic Compounds, Small Ring Heterocycles: Aziridines, Azirines, Thiiranes, Thiirenes. Hassner, Alfred ...
The synthesis of W-azirine-2-carboxylic esters fiom aziridine-2-carboxylic esters by an eliminative reaction is reported. An ... alternative preparation of 2H-azirine-2-carboxylic esters involves an alkaloid mediated synthesis from the oxime tosylates of p ...
Azirines * Iodine Radioisotopes * Macromolecular Substances * Peptide Fragments * 3-(trifluoromethyl)-3-(3-iodophenyl)diazirine ...
Alkyl-1-azirine-3-carboxylates.. D,L-ibotenic acid.. D,L-muscarine.. D,L-threo-a-amino-3)x0-5-isoxazolidineacetic acid.. D,L- ...
Visible-Light-Induced Regioselective C(sp3)-H Acyloxylation of Aryl-2H Azirines with (Diacetoxy)iodobenzene. ...
Report on the activity of derivatives of aromatic amines, nitrosamines, quinolines, nitroalkanes, amides, epoxides, azirines ...
2H-Azirine, 1-oxide. C2H3NO. 194471-09-5. Isoxazole, 5-(2-bromoethoxy)-4-phenyl-. C11H10BrNO2. ...
The best evidence for this mechanism is that the azirine intermediate has been isolated. •Both a syn and an anti ketoxime give ... Mechanism The mechanism of the Neber rearrangement is via an azirine intermediate 79. • ...
2H-Azirine,2,3-diphenyl-. C14H11 N. 190258-12-9. Edronocaine [INN]. ...
Ring Expansions of Azirines and Azetines Alexander F. Khlebnikov, Mikhail S. Novikov ...
Such azirines are readily convertible to indoles by thermolysis (. 2006, October 16) or under Rh or Fe (. 2011, June 20) ... Zheng-Hui Guan of Northwest University found mild conditions for the cyclization of the oxime acetate 28 to the azirine 29 (Org ...
... and 2-Iodo-2H-azirines via the Halex Reaction ...
X. Competition between 1,2- and 1,3-ring opening in the reaction of 3-dimethylamino-2-phenyl-2H-azirines with carbon disulfide) ... Structure and reactivity of the 1:1-adducts from 3-dialkylamino-2,2-dimethyl-2H-azirines and carbon disulfide). Ernst Schaumann ... 1:1-, 2:1-, and 3:1-Adducts from the reaction of isothiocyanates with 3-dimethylamino-2,2-dimethyl-2H-azirine). Ernst Schaumann ... 2:1]- and [3:1]-Adducts from isocyanates and 3-dimethylamino-2H-azirines). Ernst Schaumann, Susanne Grabley, Gunadi Adiwidjaja ...
Journal Article] Organocatalytic Asymmetric Neber Reaction for the Synthesis of 2H-Azirine Carboxylic Esters2011. *. Author(s) ...
Synthesis of New 2-Halo-2-(1H-tetrazol-5-yl)-2H-azirines via a Non-Classical Wittig Reaction ...
Synthesis of New 2-Halo-2-(1H-tetrazol-5-yl)-2H-azirines via a Non-Classical Wittig Reaction ...
Bogey, M.; Destombes, J.-L.; Denis, J.-M.; Guillemin, J.-C., The millimeter wave rotational spectrum of 2H-azirine, NCH2 CH, J ...
20171099 - Synthesis and chain-dependent antifungal activity of long-chain 2h-azirine-carboxylate .... 19380229 - Synthesis, ...
3] We assume that the first step is the oxidation of the azirine to the azirine radical cation, since the energy for the ... The reaction of azirines with imines offers a ready approach for the synthesis of N-substituted imidazoles with a wide variety ... Since the C-N double bonds of the imine and the azirine compete for reaction, the yields of imidazoles vary rather widely ( ... The reaction of azirines with imines leads to the formation of the N-substituted imidazoles. The course of the reaction is as ...
... leads to the fused azirine (2014b]. Ph-CO-CH2Br NaN, NaBH4 Ph-CO-CH2N3 ----+ (25) 7- P h - H CHzN3 OH SOCI, * Ph-CH-CHZN, I c1 ... such as an azirine), both regioisomers (82) and [37] G. Labbe, M. J. Miller, and A. Hassner, Chem. and Ind. 1970, 1321. 103 ( ... or via an azirine (35) to the oxazole (36): 2,S-Bisazido-3,6-di-tert-butyl-1,4-benzoquinone (41) undergoes a thermal ... and the latter an azirine (56). The ketenimine was not isolated in the free form but its presence was inferred from trapping ...
  • 2H-Azirines can be considered strained imines and are isolable. (wikipedia.org)
  • Photoinduced electron-transfer conditions (the photoexcitation of the electron acceptor naphthalenedicarbonitrile (DCN)) are required for [3 + 2] cycloadditions of azirines (1) with imines, which afford N-substituted imidazoles (3). (uni-bielefeld.de)
  • The radical cation 2 is also able to attack the C-N double bond in imines in an intermolecular fashion, a reaction not possible for photochemical 1,3-dipolar cycloaddition.16]The reaction of azirines with imines leads to the formation of the N-substituted imidazoles. (docme.ru)
  • The reaction of azirines with imines offers a ready approach for the synthesis of N-substituted imidazoles with a wide variety of substituents. (docme.ru)
  • In the case of Ph3C0 and Ph,[email protected], there were excellent matches of spectra of the transients observed in the pulse radiolysis experiments with ones obtained for solutions of authentic cations in concentrated acid and there Experimental Procedure The azirines were prepared according to[9], the imines according to[lO]. (docme.ru)
  • Imidazolophanes 3 bridged by short chains (n = 5, 6) are readily accessible by [3 + 2] cycloadditions of imines with 2, formed from the bicyclic azirines 1 under electron-transfer conditions. (uni-bielefeld.de)
  • The "azirine/oxazolone-method" offers an efficient stra- tegy for the synthesis of peptide-models used for con- formational studies. (uzh.ch)
  • Photolysis of azirines (under 300 nm) is a very efficient way to generate nitrile ylides. (wikipedia.org)
  • In the absence of HCl, the known electronic and vibrational spectra of the corresponding triplet nitrenes, azirines, and didehydroazepines were observed, whereas in the presence of HCl, photolysis of these azides produces new electronic spectra assigned to. (rero.ch)
  • Different behavior of nitrenes and carbenes on photolysis and thermolysis: formation of azirine, ylidic cumulene, and cyclic ketenimine and the rearrangement of 6-phenanthridylcarbene to 9-phenanthrylnitrene. (termsreign.gq)
  • Since the C-N double bonds of the imine and the azirine compete for reaction, the yields of imidazoles vary rather widely (Table 1). (docme.ru)
  • Semenikhina V.G. Reaction of azirines with sulfur nucleophiles. (osi.lv)
  • A DBU-promoted metal-free reaction of 2-allyl-2H-azirines affords 1-azatrienes that in situ electrocyclize to pyridines in very good yields. (ronpaulsamerica.info)
  • A novel and efficient iron-catalyzed cycloaddition reaction using readily available 2,3-diaryl-2H-azirines and primary amides is reported. (bvsalud.org)
  • 17] A. Lúcia Cardoso, A. Lemos, T.M.V.D. Pinhoe Melo, Selective Synthesis of Tetrasubstituted 4-(Tetrazol-5-yl)-1H-imidazoles from 2-(Tetrazol-5-yl)-2H-azirines, Eur. (irost.ir)
  • 2H-Azirine is most often obtained by the thermolysis of vinyl azides. (wikipedia.org)
  • 3-Amino-2,2-dialkyl-2H-azirines 1 are synthons for alpha,alpha-disubstituted alpha-amino acids. (uzh.ch)
  • 3-Amino-2H-azirines are ideal synthons for the construction of oligopeptides, cyclic peptides and depsipeptides (peptolides) containing such alpha,alpha-disubstituted alpha-amino acids. (uzh.ch)
  • Azirines are three-membered heterocyclic unsaturated (i.e. they contain a double bond) compounds containing a nitrogen atom and related to the saturated analogue aziridine. (wikipedia.org)
  • There are two isomers of azirine: 1H-azirine with a carbon-carbon double bond are not stable and rearrange to the tautomeric 2H-azirine, a compound with a carbon-nitrogen double bond. (wikipedia.org)
  • Reactivity of 2-Halo-2H-azirines. (uc.pt)
  • Using 3-amino-2H-azirines a large array of heterocycles containing alpha,alpha-disubstituted alpha-amino acids as structural elements within their skeleton can be synthesized. (uzh.ch)
  • Among the recently studied transformations of vinyl azides are their and phot~lysis[~] which serve as a general method of synthesis of azirines, a heretofore rare class of heterocycles. (docme.ru)
  • In addition, one-pot synthesis of pyridines kroenke pyridine synthesis oximes via in situ formation of 2H-azirines was achieved. (ronpaulsamerica.info)
  • An azirine is an intermediate in the Neber rearrangement. (wikipedia.org)
  • Eremeev A.V. 13C and 15N NMR spectra of 2,3-substituted 2H-azirines. (osi.lv)
  • d without our meaning any download the social of orbitals, and whether it can not be a 2-azirine article in the body. (msfdataservices.com)
  • The remaining products are the azirine Table 1. (docme.ru)
  • Download PDF '3-Amino-2H-azirines. (uzh.ch)
  • These errors betwixt the two substantiae of download gene therapy of will azirine us an false person, why the one conveys therefore not found been for the common, and why we have we have an copy of account without the foot of any penetration either of the ad or account. (qwestoffice.net)
  • d, that this download arbeitstagung bonn 2013 in must exclusively azirine it, and do it from needs depending a greater choice in the contrariety of corporeae or advantages, than what our class or NET even is same to hold. (northgeorgialivesteamers.org)
  • In this versatile approach for the incorporation of di-substituted amino acids into the peptide chain, N-protected amino acids or peptides are coupled with 3-amino-2H-azirines 1. (uzh.ch)