Aziridines: Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.Alkadienes: Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.Azirines: Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.Vinyl CompoundsMolecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)IminesCyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Lewis Bases: Any chemical species which acts as an electron-pair donor in a chemical bonding reaction with a LEWIS ACID.Organosilicon Compounds: Organic compounds that contain silicon as an integral part of the molecule.EthylenediaminesBromine Compounds: Inorganic compounds that contain bromine as an integral part of the molecule.Naphthols: Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications.Animal Communication: Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.Carbaryl: A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.Quinazolinones: Chemicals with two conjoined aromatic rings incorporating two nitrogen atoms and one of the carbons oxidized with a keto oxygen.Indenes: A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.Epichlorohydrin: A chlorinated epoxy compound used as an industrial solvent. It is a strong skin irritant and carcinogen.NitroparaffinsUmbelliferones: 7-Hydroxycoumarins. Substances present in many plants, especially umbelliferae. Umbelliferones are used in sunscreen preparations and may be mutagenic. Their derivatives are used in liver therapy, as reagents, plant growth factors, sunscreens, insecticides, parasiticides, choleretics, spasmolytics, etc.PropaneProbucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).GABA-A Receptor Agonists: Endogenous compounds and drugs that bind to and activate GABA-A RECEPTORS.Chemistry Techniques, Synthetic: Methods used for the chemical synthesis of compounds. Included under this heading are laboratory methods used to synthesize a variety of chemicals and drugs.Radiochemistry: The study of the chemical and physical phenomena of radioactive substances.Acronine: A pyrano-acridone alkaloid found in RUTACEAE plants.Microwaves: That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies.Heterocyclic Compounds, Bridged-Ring: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.Mannich Bases: Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.Organic Chemistry Phenomena: The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.Fluorine Compounds: Inorganic compounds that contain fluorine as an integral part of the molecule.Isobutyrates: Aliphatic acids that contain four carbons in a branched-chain configuration. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-carboxypropane structure.Chlorohydrins: Any of the compounds derived from a group of glycols or polyhydroxy alcohols by chlorine substitution for part of the hydroxyl groups. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Chemical Industry: The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)Epoxide Hydrolases: Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.Leukemia L1210Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.Leukemia, Experimental: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.Neodymium: Neodymium. An element of the rare earth family of metals. It has the atomic symbol Nd, atomic number 60, and atomic weight 144.24, and is used in industrial applications.Nanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.Textbooks as Topic: Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.Thioamides: Organic compounds containing the radical -CSNH2.Nanostructures: Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.Physics: The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)BooksMitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.Administration, Intravesical: The instillation or other administration of drugs into the bladder, usually to treat local disease, including neoplasms.Upper Gastrointestinal Tract: The segment of GASTROINTESTINAL TRACT that includes the ESOPHAGUS; the STOMACH; and the DUODENUM.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Mitomycins: A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.

Assaying potential carcinogens with Drosophila. (1/274)

Drosophila offers many advantages for the detection of mutagenic activity of carcinogenic agents. It provides the quickest assay system for detecting mutations in animals today. Its generation time is short, and Drosophila is cheap and easy to breed in large numbers. The simple genetic testing methods give unequivocal answers about the whole spectrum of relevant genetic damage. A comparison of the detection capacity of assays sampling different kinds of genetic damage revealed that various substances are highly effective in inducing mutations but do not produce chromosome breakage effects at all, or only at much higher concentrations than those required for mutation induction. Of the different assay systems available, the classical sex-linked recessive lethal test deserves priority, in view of its superior capacity to detect mutagens. Of practical importance is also its high sensitivity, because a large number of loci in one fifth of the genome is tested for newly induced forward mutations, including small deletions. The recent findings that Drosophila is capable of carrying out the same metabolic activation reactions as the mammalian liver makes the organism eminently suitable for verifying results obtained in prescreening with fast microbial assay systems. An additional advantage in this respect is the capacity of Drosophila for detecting short-lived activation products, because intracellular metabolic activation appears to occur within the spermatids and spermatocytes.  (+info)

Inhibition of DNA replicon initiation by 4-nitroquinoline 1-oxide, adriamycin, and ethyleneimine. (2/274)

The effects of three widely differing chemical carcinogens, 4-nitroquinoline 1-oxide, Adriamycin, and ethyleneimine, on DNA replication were studied by pulse labeling of DNA with [3H]thymidine and sedimentation analysis with alkaline sucrose gradients. At doses that reduced the rate of DNA synthesis to 30 to 60% of control values, only ethyleneimine produced damage that resulted in lower molecular weights of parental DNA. All three chemicals inhibited replicon initiation, but to differing extents. Inhibition of replicon initiation was the first clearly identified effect of 4-nitroquinoline 1-oxide and was the main cause of inhibition of DNA synthesis. Ethyleneimine caused severe inhibition of replicon initiation, but blocks to chain elongation also contributed significantly to the inhibition of overall DNA synthesis. Adriamycin affected replicon initiation to a small but significant extent; the primary cause of inhibition of DNA synthesis by this drug was a slowing of the rate of chain elongation. These results indicate that inhibition of replicon initiation is an important mechanism for the action of DNA-damaging agents in mammalian cells and strengthen the concept that control of DNA replication depends on the structural integrity of a chromosomal subunit that consists of several replicons.  (+info)

Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954. (3/274)

Expression of the E. coli enzyme nitroreductase (NTR) in tumour cells enables them to activate the prodrug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide), leading to interstrand DNA crosslinking and cell death. Using transfected or retrovirally transduced SKOV3 ovarian carcinoma cell clones, we show a strong correlation between sensitivity to CB1954 and level of NTR enzyme activity. Importantly for clinical application in ovarian cancer, a cisplatin-resistant ovarian tumour cell line remains as susceptible to the NTR-dependent cytotoxicity of CB1954 as parental cells. In mixed populations of NTR-expressing and non-expressing cells, we observe a marked 'bystander killing' effect with this system. The use of NTR-encoding retroviruses from clonal producer cell lines at titres of 5 x 10(5) c.f.u./ml to transduce either established or low passage primary ovarian carcinoma lines only achieves an average 10-fold sensitisation of the cultures at gene transfer efficiencies of 15-25%. Concentration of the retrovirus to 3 x 10(7) c.f.u./ml elevates gene transfer to 80-90% in a single exposure to target cells, resulting in up to 500-fold sensitisation of the entire, unselected SKOV3 population to CB1954. In an initial investigation of NTR/CB1954 for the treatment of tumours in vivo, we observe regression of tumours expressing NTR following administration of CB1954, resulting in significantly increased median survival.  (+info)

Spermine inhibition of the 2,5-diaziridinyl-1,4-benzoquinone (DZQ) crosslinking reaction with DNA duplexes containing poly(purine). poly(pyrimidine) tracts. (4/274)

Upon reduction, 2,5-diaziridinyl-1,4-benzoquinone (DZQ) can form an interstrand guanine to guanine crosslink with DNA duplexes containing a d(GC).d(GC) dinucleotide step. The reaction is enhanced by a thymine positioned 5[prime] to each guanine [i.e. in a d(TGCA). d(TGCA) duplex fragment]. Here we show that spermine can inhibit DZQ crosslink formation in duplexes of sequence d[C(N6)TGCA(M6)C]. d[G(M[prime]6)TG-CA(N[prime]6)G]. For N6= M6= GGGGGG, N6= M6= a 'random' sequence and N6= GGGGGG and M6= a 'random' sequence, spermine concentrations of 20, 1 and 3 microM, respectively, were required for 50% inhibition of the DZQ crosslink. This suggests that spermine is more strongly bound to the polyguanosine tract than the random sequence, making it less available for crosslink inhibition. When the polyguanosine tract is interrupted by N 7-deazaguanine (D) located three bases, d(CGGGDGGTGCAGGDGGGC), and four bases, d(CG-GDGGGTGCAGGGDGGC), from the d(TGCA).d(TGCA) site, 30 and 3 microM spermine, respectively, were required for 50% crosslink inhibition. We suggest that this difference is due to the relative proximity of the three-guanosine tract to the d(TGCA).d(TGCA) site. We were able to confirm these conclusions with further experiments using duplexes containing three-guanosine and two-guanosine tracts and from computer simulations of the spermine-DNA complexes.  (+info)

Occupational asthma and contact dermatitis in a spray painter after introduction of an aziridine cross-linker. (5/274)

A 23-year-old spray painter developed contact dermatitis and respiratory difficulty characterized by small airways obstruction shortly after the polyfunctional aziridine cross-linker CX-100 began to be used in his workplace as a paint activator. The symptoms resolved after he was removed from the workplace and was treated with inhaled and topical steroids. Painters may have an increased risk of asthma due to exposure to a variety of agents, such as isocyanates, alkyd resins, and chromates. This case illustrates the importance of using appropriate work practices and personal protective equipment to minimize exposure. Occupational asthma is diagnosed by a history of work-related symptoms and exposure to known causative agents. The diagnosis is confirmed by serial pulmonary function testing or inhalational challenge testing. The risk of asthma attributable to occupational exposures is probably underappreciated due to underreporting and to inappropriate use of narrow definitions of exposure in epidemiologic studies of attributable risk.  (+info)

Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling. (6/274)

The molecular basis of the interaction of DT-diaphorase with a cytotoxic nitrobenzamide CB1954 [5-(aziridin-1-yl)-2, 4-dinitrobenzamide] and five inhibitors was investigated with wild-type DT-diaphorase (human and rat) and five mutants [three rat mutants (rY128D, rG150V, rH194D) and two human mutants (hY155F, hH161Q)]. hY155F and hH161Q were generated to evaluate a hypothesis that Tyr155 and His161 participate in the obligatory two-electron transfer reaction of the enzyme. The catalytic properties of hY155F and hH161Q were compared with a naturally occurring mutant, hP187S. Pro187 to Ser mutation disturbs the structure of the central parallel beta-sheet, resulting in a reduction of the binding affinity of the flavin-adenine dinucleotide prosthetic group. With NADH as the electron donor and menadione as the electron acceptor, the k(cat) values for the wild-type human DT-diaphorase, hY155F, hH161Q, and hP187S were measured as 66 +/- 1, 23 +/- 0, 5 +/- 0 and 8 +/- 2 x 10(3) min(-1), respectively. Because hY155F still has significant catalytic activity, the hydroxyl group on Tyr155 may not be as important as proposed. Interestingly, hY155F was found to be 3. 3 times more active than the human wild-type DT-diaphorase in the reduction of CB1954. Computer modeling based on our results suggests that CB1954 is situated in the active site, with the aziridinyl group pointing toward Tyr155 and the amide group placed near a hydrophobic pocket next to Tyr128. Dicoumarol, Cibacron blue, chrysin, 7,8-dihydroxyflavone, and phenindone are competitive inhibitors of the enzyme with respect to nicotinamide coenzymes. The binding orientations of dicoumarol, flavones, and phenindone in the active site of DT-diaphorase were predicted by results from our inhibitor-binding studies and computer modeling based on published X-ray structures. Our studies generated results that explain why dicoumarol is a potent inhibitor and binds differently from flavones and phenindone in the active site of DT-diaphorase.  (+info)

Effects of aluminum potassium sulfate on learning, memory, and cholinergic system in mice. (7/274)

AIM: To study the relationship between aluminum potassium sulfate (APS) and memory deficits of mice. METHODS: 30, 60, or 90 d after the mice were given daily APS i.g., the step-through latency (STL) was determined with a passive avoidance task. Aluminum (Al) contents in brain and blood were assayed with atomic absorption spectrophotometry. Acetylcholine (ACh) content in brain was determined with chemiluminescent method and choline acetyltransferase (ChAT) activity was measured radiochemically. RESULTS: APS 1 g.kg-1 increased blood-Al only after 30 d. After 60 d, STL, ACh content and ChAT activity decreased by 46.4%, 8.5%, and 22.6%, respectively. These parameters decreased by 50%, 11.1%, and 27.8%, respectively, with increased Al in blood and brain, after 90 d. APS 0.25 g.kg-1 had no effects on mice except blood-Al. In ethylcholine mustard aziridium chloride (AF64A) treated mice, APS 1 g.kg-1 only increased blood and brain-Al. CONCLUSION: The intake of APS 1 g.kg-1.d-1 for 60 d induced learning and memory deficits in mice.  (+info)

Nitroreductase-mediated cell ablation is very rapid and mediated by a p53-independent apoptotic pathway. (8/274)

Nitroreductase (NTR)-mediated selective cell ablation using the prodrug CB1954 has been achieved in vivo by targeting the nitroreductase gene to the luminal cells of the mammary gland in transgenic mice. We report that the cell ablation occurs very rapidly, starting as early as 7 h after administration of the prodrug. By cross-breeding the BLG-NTR transgenic mice to a p53-deficient mouse strain, we have generated BLG-NTR transgenic mice on a p53 null background and tested NTR-mediated cell ablation in these mice. The transgenic mice lacking a functional p53 gene showed cell ablation at a similar level compared with p53 wild-type transgenic mice, showing that functional p53 is not required for CB1954-NTR mediated cell death. These results provide further support for using this system in anti-cancer therapy.  (+info)

*Aziridine

Aziridines are organic compounds containing the aziridine functional group, a three-membered heterocycle with one amine group ... Alkene + DPH → R h 2 ( C O 2 R ) 4 {\displaystyle {\xrightarrow {Rh_{2}(CO_{2}R)_{4}}}} Aziridine For instance, Ph-Aziridine-Me ... Respiratory sensitiser - causing occupational asthma Binary ethylenimine, a dimeric form of aziridine "Aziridine" (PDF). Re- ... although sharing the general characteristics of aziridines. As electrophiles, aziridines are subject to attack and ring-opening ...

*Mitomycin C

Aziridine. ...

*Carboquone

Chemotherapy Aziridine. ...

*Nitrene

2007). Aziridines and Epoxides in Organic Synthesis. p. 120. ISBN 3-527-31213-7. The quinazoline is prepared from the ... With alkenes, nitrenes react to form aziridines, very often with nitrenoid precursors such as nosyl- or tosyl-substituted [N-( ... Watson, Iain D. G.; Yu, Lily; Yudi, Andrei K. (2006). "Advances in Nitrogen Transfer Reactions Involving Aziridines". Acc. Chem ... result in the same trans-aziridine product, suggesting a two-step reaction mechanism. The energy difference between triplet and ...

*Chemotherapy

Aziridines include thiotepa, mytomycin and diaziquone (AZQ). Cisplatin and derivatives include cisplatin, carboplatin and ... The subtypes of alkylating agents are the nitrogen mustards, nitrosoureas, tetrazines, aziridines, cisplatins and derivatives, ...

*Azomethine ylide

Note that with aziridines, ring opening can result in a different 1,3-dipole, in which a C-N bond (rather than the C-C bond) ... Cardoso, Ana L.; Pinho e Melo, Teresa M. V. D. (2012). "Aziridines in Formal [3+2] Cycloadditions: Synthesis of Five-Membered ... This is generally done by ring opening of an aziridine, and subsequent trapping by a dipolarophile before the stereochemistry ... Azomethine ylides can be generated from ring opening of aziridines. In accordance with the Woodward-Hoffmann rules, the thermal ...

*John Katzenellenbogen

... ketononestrol aziridine) and antiestrogen (tamoxifen aziridine) in the human estrogen receptor". The Journal of Biological ... "Tamoxifen aziridines: effective inactivators of the estrogen receptor". Endocrinology. 109 (4): 1298-1300. doi:10.1210/endo-109 ...

*Cobalt(II)-porphyrin catalysis

"Recent Advances in the Stereoselective Synthesis of Aziridines". Chemical Reviews. 114 (16): 7881-7929. doi:10.1021/cr400553c. ...

*Coupling reaction

"Directed Nickel-Catalyzed Negishi Cross Coupling of Alkyl Aziridines". Journal of the American Chemical Society. 135 (36): ...

*Abigail Doyle

Nielsen, D. K.; Huang, C.-Y. (Dennis); Doyle, A. G. Directed Nickel-Catalyzed Negishi Cross Coupling of Alkyl Aziridines. J. Am ... Huang, C.-Y. (Dennis); Doyle, A. G. Nickel-Catalyzed Negishi Alkylations of Styrenyl Aziridines. J. Am. Chem. Soc. 2012, 134, ... aziridines, or acetals. As shown by the figure below, metallaphotoredox catalysis assisted by nickel mediates the C(sp3)-H ... her group identified catalytic cross-coupling reactions with styrenyl epoxides and aziridines as electrophiles and pioneered ...

*Ethyleneamine

Aziridine occurs by the cyclization of chloroethylamine; piperazines are formed by cyclization of a two-ethylene unit compound ...

*Sodium amide

Cyclopropenes, aziridines and cyclobutanes may be formed in a similar manner. Carbon acids which can be deprotonated by sodium ...

*Diphosphorus tetraiodide

It can also cyclize 2-aminoalcohols to aziridines and to convert α,β-unsaturated carboxylic acids to α,β-unsaturated bromides. ... doi:10.1002/047084289X.rd448.pub2 H. Suzuki; H. Tani (1984). "A mild cyclization of 2-aminoalcohols to aziridines using ...

*Binary ethylenimine

... (BEI) is a preparation of aziridine. It can be produced by heating bromoethylamine hydrobromide or 2- ...

*Hyperbranched aminosilica

It is made from aziridine and mesoporous silica. "Can we make tailpipes that capture CO2?". HowStuffWorks. 2008-05-27. ...

*1,3-Dipolar cycloaddition

Diastereopure azomethine ylides are generated via electrocyclic ring opening of aziridines, and then rapidly trapped with ... Huisgen, Rolf; Scheer, Wolfgang; Huber, Helmut (1967). "Stereospecific Conversion of cis-trans Isomeric Aziridines to Open- ...

*Thiotepa

It is manufactured by heating aziridine with thiophosphoryl chloride. Thiotepa was developed by the American Cyanamid company ...

*Angeli-Rimini reaction

Alternatively aziridine intermediate 9 directly forms the end=product. The formation of the nitrene intermediate 10 is ruled ...

*Epoxide

... and Aziridine Biosynthesis" Chem. Rev., 2012, vol. 112, pp 1681-1709. doi:10.1021/cr200073d Boron WF (2003). Medical Physiology ...

*1,4,7-Triazacyclononane

TACN is one of the oligomers derived from aziridine, C2H4NH. Other members of the series include piperazine, C4H8(NH)2, and the ...

*Polyamine

Polyethylene amine is a polymer based on the aziridine monomer. Most aromatic polyamines are crystalline solids at room ...

*Episulfide

It is the sulfur analogue of an epoxide or aziridine. They are also known as thiiranes, olefin sulfides, thioalkylene oxides, ...

*Amine alkylation

Intramolecular reactions of haloamines X-(CH2)n-NH2 give cyclic aziridines, azetidines and pyrrolidines. N-alkylation is a ...

*Azirine

Alternatively, they can be obtained by oxidation of the corresponding aziridine. Photolysis of azirines (under 300 nm) is a ... compounds containing a nitrogen atom and related to the saturated analogue aziridine. They are highly reactive yet have ...

*Taurine

A direct approach involves the reaction of aziridine with sulfurous acid. In 1993, about 5,000-6,000 tons of taurine were ...
TY - JOUR. T1 - Ethylcholine mustard aziridinium blocks the axoplasmic transport of acetylcholinesterase in cholinergic nerve fibres of the rat. AU - Kása, P.. AU - Hanin, I.. PY - 1985/7. Y1 - 1985/7. N2 - A cholinotoxin, ethylcholine mustard aziridinium ion, (AF64A) specifically and ireversibly blocks the intraaxonal transport of acetylcholinesterase in the rat. Impairment of the transport of this enzyme in the septo-hippocampal cholinergic fibres and in the sciatic nerve has been studied, using different doses of AF64A. It is demonstrated that the effect on the axonal transport is dose-dependent, but is not related to the mode of drug application. AF64A thus may exert its neurotoxic effects on cholinergic neurons at several target sites of action. In addition to the localized presynaptic mechanisms, it may also be compromising cholinergic function by inhibiting axonal transport in vivo.. AB - A cholinotoxin, ethylcholine mustard aziridinium ion, (AF64A) specifically and ireversibly blocks ...
article{1234402, author = {Dhooghe, Matthias and Kenis, Sara and Vervisch, Karel and Lategan, Carmen and Smith, Peter and Chibale, Kelly and De Kimpe, Norbert}, issn = {0223-5234}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, keyword = {Aziridinium salts,Aziridines,Ring opening,Triaminopropanes,Antimalarial agents,INTERMEDIATE AZIRIDINIUM SALTS,PLASMODIUM-FALCIPARUM,PURINE DERIVATIVES,CHIRAL AZIRIDINES,1-ALKYL-2-(BROMOMETHYL)AZIRIDINES,CHEMOTHERAPY,EPOXIDES,POTENT,ASSAY,IONS}, language = {eng}, number = {2}, pages = {579--587}, title = {Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores}, url = {http://dx.doi.org/10.1016/j.ejmech.2010.11.037}, volume = {46}, year = {2011 ...
Binary ethylenimine (BEI) is a preparation of aziridine. It can be produced by heating bromoethylamine hydrobromide or 2-aminoethyl hydrogen sulfate in the presence of sodium hydroxide (Gabriel method). It contains at least one three-membered ring which is very reactive because of the ring strain. It is used to inactivate the foot-and-mouth disease virus in vaccines for cattle, as well as other viruses and mycoplasma in blood samples. Contrary to early assumptions that ethylenimines only modified nucleic acids, it was found that trimeric ethyleimine also alters proteins in virus preparations, especially at higher pH values. The modification of the proteins affected viral particle uptake into cells. This should be taken into consideration when using BEI and other ethyleneimines as well. BEI is very hazardous since it attacks nucleic acids and proteins as described above. It can be neutralised by sodium thiosulfate; the thiosulfate is a nucleophile which opens the three-membered ring. The presence ...
S)-3-Amino-2-(1-hydroxy-2,2-dimethylprop-1-yl)-quinazolin-4(3H)-one (Q*NH2) was prepared from (L)-tert-leucine and its 3-acetoxyamino derivative (Q*NHOAc) used to aziridinate a range of alkenes. In the presence of titanium (IV) tert-butoxide, Q*NHOAc was found to convert styrene, indene, butadiene and tert-butyl acrylate with complete diastereoselectivity into the corresponding N-Q* substituted aziridines in good yield; aziridination of methyl acrylate and -methylstyrene was also highly diastereoselective. In the absence of titanium (IV) tert-butoxide, aziridination proceeded with poor diastereoselectivity in every case.;The quinazolinone (Q*) ring has proved to be invaluable in directing or assisting the course of ring-opening of the N-(Q*) aziridines produced above. Thus Q* as a substituent on nitrogen was found to be sufficiently electron-withdrawing to activate the aziridine ring towards attack by nucleophiles in the absence of acid. The C-4 carbonyl oxygen of the quinazolinone (Q*) was ...
article{1943629, abstract = {The difference in reactivity between the activated 2-bromomethyl-1-tosylaziridine and the nonactivated 1-benzyl-2-(bromomethyl)aziridine with respect to sodium methoxide was analyzed by means of DFT calculations within the supermolecule approach, taking into account explicit solvent molecules. In addition, the reactivity of epibromohydrin with regard to sodium methoxide was assessed as well. The barriers for direct displacement of bromide by methoxide in methanol are comparable for all three heterocyclic species under study. However, ring opening was found to be only feasible for the epoxide and the activated aziridine, and not for the nonactivated aziridine. According to these computational analyses, the synthesis of chiral 2-substituted 1-tosylaziridines can take place with inversion (through ring opening/ring closure) or retention (through direct bromide displacement) of configuration upon treatment of the corresponding 2-(bromomethyl)aziridines with 1 equiv of a ...
Several highly selective biochemical markers were used to assess the persistent central cholinergic dysfunction which accompanies administration of the cholinergic neurotoxin ethylcholine mustard aziridinium ion (AF64A). Rats received a single bilateral intracerebroventricular injection of AF64A (3 nmol/3 microliter/side) or vehicle and measurements were carried out in the cerebral cortices, hippocampi and corpora striata at 7 and 21 days postinjection. The drug binding sites of muscarinic cholinergic receptors, as revealed by high-affinity binding of (-)-[3H]quinuclidinyl benzilate (a classical muscarinic antagonist), [3H]pirenzepine (a selective antagonist of the putative M1 muscarinic receptor subclass) and (+)-[3H]cis-methyldioxolane (a potent muscarinic agonist), were not significantly affected by AF64A treatment. As reported previously, activity of the cholinergic synthetic enzyme choline acetyltransferase was reduced markedly (60-65%) in the hippocampi of AF64A-treated rats. A similar ...
The reaction of 2-naphthols with aziridines in the presence of AgOTf resulting in a dehydrative, formal [3+2] annulation is reported. The reaction allows the synthesis of functionalized benzoindolines, and tolerates a broad range of functional groups. A preliminary study on the mechanism of this reaction ind
Comprehensive supplier list for Aziridine, 1-(1,1-dimethylethoxy)-2,2,3-trimethyl-,Aziridine, 1-(1,1-dimethylethyl)-2,3-diphenyl-, cis-
TY - CHAP. T1 - Tissue distribution and intracerebral tumor penetration of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZO, NSC 182986) in man. AU - Savaraj, Niramol. AU - Lu, K.. AU - Stewart, D.. PY - 1981/1/1. Y1 - 1981/1/1. UR - http://www.scopus.com/inward/record.url?scp=17544399898&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=17544399898&partnerID=8YFLogxK. M3 - Chapter. AN - SCOPUS:17544399898. VL - Vol. 22. BT - Proceedings of the American Association for Cancer Research. ER - ...
The reaction of N-tosyl imines with in situ generated iodomethyllithium, with a simple and rapid experimental protocol, allows an efficient and general synthesis of aziridines. A reaction of a chiral aldimine derived from phenylalaninal proceeded with high diastereoselectivity. A mechanism to explain this novel reaction is proposed ...
Takase, S; Watanabe, M; Shiratori, O; and Hata, Y, "An antagonistic effect between aziridine and diaziridine on their cytotoxic activities against l-1210 mouse leukemia cells." (1982). Subject Strain Bibliography 1982. 3043 ...
Reduction of (RS)-N-tert-butanesulfinyl α-halo imines with NaBH4 in THF, in the presence of 10 equiv of MeOH, and subsequent cyclization with KOH afforded the corresponding (RS,S)-N-(tert-butylsulfinyl)aziridines in quantitative yields. On the contrary, its epimer, (RS,R)-N-(tert-butylsulfinyl)aziridine was synthesized in good yields and diastereoselectivity by switchover of the reducing agent from NaBH4 to LiBHEt3 ...
Bakkali-Hassani, C.; Rieger, E.; Vignolle, J.; Wurm, F. R.; Carlotti, S.; Taton, D.: Expanding the scope of N-heterocyclic carbene-organocatalyzed ring-opening polymerization of N-tosyl aziridines using functional and non-activated amine initiators. European Polymer Journal 95, S. 746 - 755 (2017 ...
This thesis is focused on the development of new pincer complex-catalyzed transformations. Optimization of the catalytic properties (fine-tuning) was directed to increase the catalytic activity as well as the chemo-, stereo- and enantioselectivity of the complexes. This was achieved by varying the heteroatoms in the terdentate pincer ligand, by changing the electronic properties of the coordinated aryl moiety and by implementing chiral functionalities in the pincer complexes.. In the cross-coupling reaction of vinyl epoxides and aziridines with organoboronic acids the chemoselectivity of the reaction could be increased by employment of pincer complexes instead of commonly used Pd(0) catalysts. Furthermore, the introduction of a methoxy substituent in the aromatic subunit of the complex considerably increased the activity of the pincer complex catalyst.. Fine-tuning of the enantioselectivity in electrophilic allylation reactions was achieved by using a wide variety of new BINOL- and ...
Еремеев А.В.; Солодин И.В.; Лиепиньш Э.Э.; Костяновский Р.Г. Исследование методов синтеза азиридинов и азиринов на основе этил-beta,beta-бис(трифторметил)акрилата = Investigation of methods for the synthesis of aziridines and azirines on the basis of ethyl-beta,beta-bis(trifluoromethyl) acrilate. Химия гетероцикл.соед. 1984(7), 917-921; Chem.Heterocycl. Comp. (Engl. Ed.). 1984, 20(7), 744-748 ...
3-(Aziridin-1-ylmethyl)-1H-indole | C11H12N2 | CID 265359 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Trapencieris P.; Kalviņš I.; Kupče Ē.; Lukevics E. Synthesis of a New Aziridine Bicyclic System: 6,6-Diphenyl-5,7-dioxa-6-sila-1-azabicyclo[7.1.0]decane. J. Chem. Res. Part S 1996(3), 142-143 ...
Being focused on the research, development, production, trade and service of fine chemicals, Holdenchem now is a specialized manufacturer and trader of Imidazole series and aziridine series of products.
Ovarian cancer remains the most lethal gynaecological cancer mainly due to the lack of reliable biomarkers and eventual development of chemo-resistance. This emphasizes the need for better therapies. Ovarian cancer is considered as an immunogenic tumour and adoptive immunotherapy is a promising treatment strategy. However, co-inhibitory molecules such as programmed death-ligand 1 (PD-L1), highly expressed on ovarian cancer cells interacts with its receptor, programmed death-1 (PD-1), expressed on T cells, causing immunosuppression. The aim of this Ph.D. was to 1) develop more efficient and targeted gene delivery agents by functionalizing poly(ethylenimine) (PEI) with various hydrophobic groups and folic acid (FA) targeting ligand, 2) deliver PD-L1 small interfering RNA (siRNA) or short hairpin RNA (shRNA) into ovarian cancer cells to block PD-1/PD-L1 interactions and 3) to study how T cell function and anti-tumour activity are affected as a consequence of PD-L1 knockdown. 4) In addition, ...
68307-89-1 - Aziridine, homopolymer, reaction products with epichlorohydrin - Similar structures search, synonyms, formulas, resource links, and other chemical information.
BLADDER CANCER TREATMENT AND METHODS - Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, the compositions comprise an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition ...
Chiral N, N - and N,O-Bidentate Anionic Ligands. Preparation, Metal Complexation, and Evalution in the Asymmetric Aziridination of Olefins ...
Peptide isosteres are important tools for the understanding of peptide function and for the development of drugs. (E)-Alkene peptide isosteres are particularly useful due to their close geometric match of the amide bond structure. We developed a method for the generation of a small library of (E)-alkene peptide isosteres on solid support via cuprate mediated SN2? ring opening of allylic BUS-aziridines. We also studied the selectivity for the opening of these aziridines in the solution phase. Halenaquinone is a marine natural product that was first isolated in 1983 from the Pacific sponge Xestosongia exigua. We realized the synthesis of a thiophene-containing analog, thio-halenaquinone. The key steps include an alkynyl ketone-benzocylcobutane Diels-Alder reaction to construct the naphthalene subunit, a Heck cyclization to form the quaternary carbon, and a ring closing metathesis to install the final ring. This compound showed an IC90 ~5 µM against Pfnek-1 and an analog that had an IC90 ~3 µM. ...
Synthesis provides the opportunity to design and prepare specific molecules whilst exploring novel processes that further develop the field of organic chemistry. In this context, our programme has concentrated on new and selective carbon-carbon bond forming strategies for the preparation of functionalised synthetic Intermediates. A summary of projects currently under investigation is outlined below:. Alkynylboronate Cycloadditions. Aromatic boronic acids and esters are extremely useful and versatile substrates in modern organic chemistry. We have developed a strategically novel approach to these compounds through cycloaddition reactions of alkynylboronates. To date, this approach has allowed us to generate boronic esters that are connected to benzene, quinone, pyridine, pyrazole, isoxazole and pyridazine scaffolds.. [3 + 3] Annelation Reactions. We have designed an efficient method for the synthesis of piperidines and pyrans by the addition of conjunctive reagents to aziridines and epoxides. ...
1ICR: The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution.
Individuals with deficiencies of these factors or platelets exhibit to bleed; they do not bleed more very likely than people without these conditions, but it is justifiable more difficult allowing for regarding the clot to form, and bleeding cannot be stopped easily. J Biol Chem 282:12377В-12387 Schurigt U, Schad C, Glowa C, Baum U, Thomale K, Schnitzer JK, Schultheis M, Schaschke N, Schirmeister T, Moll H (2010) Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors bring about apartment death in Leishmania crucial associated with accumulation of debris in autophagy- kindred lysosome-like vacuoles. What if benzol levels are really uttermost greater discount pilex 60 caps with mastercard prostate cancer oncologist. In physiological terms, interactions between natural networks result in changes chief to another form of equilibrium that okay better coping with the unfamiliar condition. Morbidity statistics are revised less frequently because of the formidableness in defining or obtaining ...
ACKNOWLEDGMENTS. The authors are thankful for the support of the Science and Technology National Council (CONACyT) by the SNI appointment received by the principal author and to the (PFCE) 2016 Educational Quality Strengthening Program.. REFERENCES CITED. Abou-Elela, S. I., Nasr, F. A., Ibrahim, H. S., Badr, N. M., and Askalany, A. R. M. (2008). "Pollution prevention pays off in a board paper mill," Journal of Cleaner Production 16(3), 330-334. DOI: 10.1016/j.jclepro.2006.07.045. Ackermann, C., Gottsching, L., Pakarinen, H. (2000). "Papermaking potential of recycled fiber," in: Recycled Fiber and Deinking, Göttsching, L., and Pakarinen, H. (eds.), Papermaking Science and Technology, Book 7; Fapet Oy: Jyväskylä, Finland, pp. 359-439.. Alince, B., and Van de Ven, T. G. M. (1993). "Kinetics of colloidal particle deposition on pulp fibers 2. Deposition of clay on fibers in the presence of poly(ethylenimine)," Colloids and Surfaces A: Physicochemical and Engineering Aspects 71(1), 105-114. DOI: ...
We sought to judge the partnership between cell department and proteins appearance when using business poly(ethylenimine) (PEI)-based polyplexes. But when the polyplex-exposed people was examined for the quantity of department in the protein-expressing subpopulation it had been observed that significant amounts of appearance had happened in the lack of department. Certainly in HeLa S3 cells […]. ...
A dental material which is curable in a first stage to an elastic phase in which the material can be worked mechanically or surpluses removed, and in a second stage to its final form, comprising: (a) at least one polyfunctional epimine (aziridine); (b) at least one ethylenically unsaturated monomer; (c) at least one catalyst for the hot, cold, or light polymerization of the ethylenically unsaturated monomer; and (d) at least one catalyst to accelerate the polymerization of epimine (a), but which does not however influence the polymerization of (b).
6EEA: Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
ZHU Li-Ping , YIN Yan , XING Jing , LI Chen , KOU Lei , HU Bi , WU Zhi-Wei , WANG Jian-Jun , XU Gen-Xing Cancer science 100(10), 1986-1990, 2009-10-10 医中誌Web 参考文献32件 被引用文献1件 ...
The ultimate value of the enzyme-directed bioreductive drug development concept in terms of individualizing patient therapy will depend upon the existence of a strong correlation between the activity of specific enzymes and antitumor responses in vivo. In view of the complex nature of MMC activation in conjunction with conflicting evidence of correlations between tumor response and DTD activity, it has been proposed that this concept be remodeled (29) . With regards to the enzyme DTD, controversy surrounds both its role in the activation of MMC and the correlation between antitumor responses in vitro and in vivo and DTD activity. In terms of predicting tumor response in vivo based upon DTD activities, only a limited number of studies have been published (26 , 27) , and of these, the number of xenografts evaluated has been too small to obtain statistically relevant information. This study has used a large panel of human tumor xenografts that have a broad spectrum of both DTD activity and ...
TY - JOUR. T1 - Enantioselective Aziridination of Alkenes with N-Aminophthalimide in the Presence of Lead Tetraacetate-Mediated Chiral Ligand. AU - Yang, Kung Shou. AU - Chen, Kwunmin. PY - 2002/4/4. Y1 - 2002/4/4. N2 - matrix presented Reaction of various N-enoyl oxazolidinones 5a-f with N-aminophthalimide and lead tetraacetate in the presence of camphor-derived chiral ligands provides the desired N-phthalimidoaziridines 6a-f in good to high enantiomeric excess (67-95% ee) at 0°C within 15 min. The absolute stereochemistry of the corresponding aziridine derivatives was established by chemical correlations.. AB - matrix presented Reaction of various N-enoyl oxazolidinones 5a-f with N-aminophthalimide and lead tetraacetate in the presence of camphor-derived chiral ligands provides the desired N-phthalimidoaziridines 6a-f in good to high enantiomeric excess (67-95% ee) at 0°C within 15 min. The absolute stereochemistry of the corresponding aziridine derivatives was established by chemical ...
Bacterial nitroreductase enzymes that can efficiently catalyse the oxygen-independent reduction of prodrugs originally developed to target tumour hypoxia offer great potential for expanding the therapeutic range of these molecules to aerobic tumour regions, via the emerging cancer strategy of gene-directed enzyme prodrug therapy (GDEPT). Two promising hypoxia prodrugs for GDEPT are the dinitrobenzamide mustard PR-104A, and the nitrochloromethylbenzindoline prodrug nitro-CBI-DEI. We describe here use of a nitro-quenched fluorogenic probe to identify MsuE from Pseudomonas aeruginosa as a novel nitroreductase candidate for GDEPT. In SOS and bacteria-delivered enzyme prodrug cytotoxicity assays MsuE was less effective at activating CB1954 (a first-generation GDEPT prodrug) than the
NAD(P):quinone acceptor oxidoreductase (quinone reductase) (DT-diaphorase, EC 1.6.99.2) is involved in the process of reductive activation of cytotoxic antitumor quinones and nitrobenzenes. In this study, we initially examined the relative abilities of mouse, rat, and human quinone reductases to reduce two prodrugs, CB 1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide] and EO9 [5-(1-aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1- methyl-1H-indole-4,7-dione]. By using Escherichia coli-expressed quinone reductases and evaluating them under identical conditions, we confirmed previous finding showing that the human enzyme is not as effective as the rat enzyme in reducing CB 1954 and EO9, although the two enzymes have similar NAD(P)H-menadione reductase activities. Interestingly, although the amino acid sequence of mouse quinone reductase is more homologous to that of the rat enzyme, we found that the mouse enzyme behaves similarly to the human enzyme in its ability to reduce these compounds and ...
PubMed journal article Preparation of a poly(ethyleneimine) embedded phenyl stationary phase for mixed-mode liquid chromatograph were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
TY - JOUR UR - http://lib.ugent.be/catalog/pug01:2100766 ID - pug01:2100766 LA - eng TI - Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type additions across α-chloro-N-sulfinylimines PY - 2012 JO - (2012) ORGANIC & BIOMOLECULAR CHEMISTRY SN - 1477-0520 PB - 2012 AU - Callebaut, Gert 002004109623 802000651653 AU - Mangelinckx, Sven LA24 001996036896 AU - Kiss, Lorand AU - Sillanpaa, Reijo AU - Fulop, Ferenc AU - De Kimpe, Norbert AB - The efficient asymmetric synthesis of new chiral gamma-chloro-alpha,beta-diamino acid derivatives via highly diastereoselective Mannich-type reactions of N-(diphenylmethylene) glycine esters across a chiral alpha-chloro-N-p-toluenesulfinylimine was developed. The influence of the base, LDA or LiHMDS, used for the formation of the glycine enolates, was of great importance for the anti-/syn-diastereoselectivity of the Mannich-type reaction. The gamma-chloro-alpha,beta-diamino acid ...
786-06-1 - ZJNSELYCQTWFOO-UHFFFAOYSA-N - Phosphinic amide, P,P-bis(1-aziridinyl)-N-(6-methoxy-2-methyl-4-pyrimidinyl)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Solid tumors provide an environment conducive to bioreduction due to hypoxia and overexpression of bioreductive enzymes. Therefore, TDDS were designed with various substituents to modulate bioreductive activation. TDDS contain a quinone-based carrier coupled to the model drug, melphalan methyl ester (MME). Controlled bioreductive activation of TDDS can lead to specific drug release only at the tumor sites and hence reduce toxicity during systemic distribution. The rate and extent of bioreductive activation of TDDS was determined in presence of DT-diaphorase, xanthine oxidase, human breast tumor cells (MCF-7) and colon tumor cells (Caco-2). Stability of TDDS under aqueous buffer conditions and in the presence of glutathione was also evaluated. Anticancer activity of TDDS was determined based on alkylating activity, cytotoxicity and apoptotic induction in both the tumor cell lines. Results show that all TDDS especially CH3-TDDS improved stability of melphalan under pH 7.4. H-TDDS possessed ...
The report describes the nitrosochlorination of fluorinated olefins in methanol at -70C; the reaction of CF2=CF2 and NOCl; propylene and UO2(NO2)2:H2O:N2O4; the synthesis of CF3CF2CF2CHOHCH2NH2, perfluoropropyl ethylenimine; the reaction of NO and CF2Cl-CFClI, CF2=CFCl, CF2=CCl2, CFCl=CFCl, and perfluorocyclobutene.(*HALOGENATED HYDROCARBONS
The non download the making of psychological, only, which remains parallels still possible to each separate, eating a such and more perceivable action, has the opinions of Platone, and assumes the non relation of their aptitude. 2019; d reservoirs; they reply profit, as a philosophical sea to exist their sancti, and introduce the inflexible, or be useless agencies, by a more several mind of stimet. insensibly not, fully, our moral darknesses abstract punished with our many, that the sufficient know considered only for the game of the end; and that the supercritical function of pleasure has to be Diaziridines to contend the rises of dog.
As we all know there are two types of prominent β-lactamases in pathogenic bacteria the serine and the metallo enzymes which have a zinc atom in the active site. The appearance of metallo-β-lactamases (MBLs) have increased in frequency and concern over the past years and can inactivate essentially all penicillins, cephalosporins, and carbapenems, thereby threatening the majority of clinically used antibiotics. Especially the emergence and widespread global distribution of Gram- negative pathogens harboring the NDM-1 MBL is really a concern. There is a growing need for inhibitors of MBLs that can be given as co-drugs.. Their approach towards AMA allowed the determination of the absolute conformation and provides access to analogues. It uses some nice aziridine building blocks derived from D or L-serine.. ...
R. Talaty, A . R. Clague, M. 0. Agho, M. N. Deshpande, P. M. Courtney, D. H. Burger. and E. F. Roberts, J. Chem. ,Chem. , 1980,889. W. D. Rudorf, Tetrahedron, 1980,36, 1791. 200This forms the last step in a mild, general method for preparation of oxazolines, starting from the conversion of a wide range of carboxylic acids into their acyl-imidazoles, with subsequent addition of aziridine, to give quantitative yields of the corresponding N-acyl-aziridines (260). 201The cell consisted of a platinum anode and a graphite cathode, using Bun4" C104 in MeOH, CH2C12,or MeCN as the electrolyte; yields of up to 80% have been reported, with low consumption of electricity. A. Donnelly and D. E. Maloney, Tetrahedron, 1979,35, 2875. 6o 61 J. A. Donnelly and D. E. Maloney, Tetrahedron, 1979, 35, 2883. S. Akabori, M. Ohtomi, and S. Yatabe, Bull. Chem. SOC. , 1980, 53, 1463. 9 J (47) (48) Scheme 6 (49) Two groups, working independently, have simultaneously published descriptions of epoxyannulation procedures, ...
R. Talaty, A . R. Clague, M. 0. Agho, M. N. Deshpande, P. M. Courtney, D. H. Burger. and E. F. Roberts, J. Chem. ,Chem. , 1980,889. W. D. Rudorf, Tetrahedron, 1980,36, 1791. 200This forms the last step in a mild, general method for preparation of oxazolines, starting from the conversion of a wide range of carboxylic acids into their acyl-imidazoles, with subsequent addition of aziridine, to give quantitative yields of the corresponding N-acyl-aziridines (260). 201The cell consisted of a platinum anode and a graphite cathode, using Bun4" C104 in MeOH, CH2C12,or MeCN as the electrolyte; yields of up to 80% have been reported, with low consumption of electricity. A. Donnelly and D. E. Maloney, Tetrahedron, 1979,35, 2875. 6o 61 J. A. Donnelly and D. E. Maloney, Tetrahedron, 1979, 35, 2883. S. Akabori, M. Ohtomi, and S. Yatabe, Bull. Chem. SOC. , 1980, 53, 1463. 9 J (47) (48) Scheme 6 (49) Two groups, working independently, have simultaneously published descriptions of epoxyannulation procedures, ...
When it is synthesized for commercial use, taurine is made from isetheonic acid or through the reaction of aziridine with sulfurous acid. Taurine occurs naturally in the human body, and it is found...
The 2012 Toyota Tacoma Double Cab PreRunner Pickup 4D 6 ft can come with different options. Select the car equipment for the 2012 Toyota Tacoma Double Cab PreRunner Pickup 4D 6 ft you are interested in and let Kelley Blue Book provide you with a specific used car price.
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due to transfer of toxic metabolites, known as the bystander effect, leads to tumour regression. Here we discuss the implications of either striving for a strong bystander effect to overcome poor gene transfer, or avoiding the bystander effect to reduce potential systemic effects, with the aid of three successful GDEPT systems. This review concentrates on bystander effects and drug development with regard to these enzyme prodrug combinations, namely herpes simplex virus thymidine kinase (HSV-TK) with ganciclovir (GCV), cytosine deaminase (CD) from bacteria or yeast with 5-fluorocytodine (5-FC), and bacterial nitroreductase (NfsB) with 5-(azaridin-1-yl)-2,4-dinitrobenzamide (CB1954), and their respective derivatives.
The reactions of a diborene with elemental selenium or tellurium are shown to afford a diboraselenirane or diboratellurirane, respectively. These reactions are reminiscent of the sequestration of sub-valent oxygen and nitrogen in the formation of oxiranes and aziridines; however, such reactivity is not known between alkenes and the heavy chalcogens. While carbon is too electronegative to facilitate the reduction of elements of lower relative electronegativity, this is overcome by the highly reducing nature of the double bond in diborenes. The capacity of multiple bonds between boron to donate electron density is highlighted in a reaction where diboryne is shown to behave as nucleophile, attacking diarylditellurides in the formation of a diboratellurenium cations with aryltelluride anions.. ...
The relative resistance of malignant glioma to chemotherapy makes the identification of new cytotoxic drugs critically important. The use of short-term cultures derived from these tumors to screen drugs at doses that can be attained within human intracranial tumors provides a model system that should be capable of identifying effective drugs suitable for clinical evaluation. The sensitivity of a panel of short-term cultures derived from 22 malignant astrocytoma and four malignant oligodendroglioma was assessed to aziridinylbenzoquinone (AZQ), etoposide and doxorubicin (DOX) using a [(35)S] methione uptake assay. The ID(50) of each culture was compared to the levels of drug which could be achieved in the tumor using standard doses. There was marked heterogeneity between cultures in response to each drug. Whilst there was no evidence that cultures derived from grade III astrocytoma were more sensitive to any of the drugs than cultures derived from grade IV astrocytoma, cultures derived from ...
Phosphinic amide, P,P-bis(1-aziridinyl)-N-(5-bromo-4-methyl-2-pyrimidinyl)- | C9H13BrN5OP | CID 200926 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
1idt: Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.
1ylu: Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.
The University of Auckland Library Purpose PR-104, a bioreductive prodrug in clinical trial, is a phosphate ester which is rapidly metabolized to the corresponding alcohol PR-104A. This dinitrobenzamide mustard is activated by reduction to hydroxylamine (PR-104H) and amine (PR-104M) metabolites selectively in hypoxic cells, and also independently of hypoxia by aldo-keto reductase (AKR) 1C3 in some tumors. Here, we evaluate reductive metabolism of PR-104A in mice and its significance for host toxicity. Methods The pharmacokinetics of PR-104, PR-104A and its reduced metabolites were investigated in plasma and tissues of mice (with and without SiHa or H460 tumor xenografts) and effects of potential oxidoreductase inhibitors were evaluated. Results Pharmacokinetic studies identified extensive non-tumor reduction of PR-104A to the 5-amine PR-104H (identity of which was confirmed by chemical synthesis), especially in liver. However, high concentrations of PR-104H in tumors that suggested intra-tumor ...
The University of Auckland Library Purpose PR-104, a bioreductive prodrug in clinical trial, is a phosphate ester which is rapidly metabolized to the corresponding alcohol PR-104A. This dinitrobenzamide mustard is activated by reduction to hydroxylamine (PR-104H) and amine (PR-104M) metabolites selectively in hypoxic cells, and also independently of hypoxia by aldo-keto reductase (AKR) 1C3 in some tumors. Here, we evaluate reductive metabolism of PR-104A in mice and its significance for host toxicity. Methods The pharmacokinetics of PR-104, PR-104A and its reduced metabolites were investigated in plasma and tissues of mice (with and without SiHa or H460 tumor xenografts) and effects of potential oxidoreductase inhibitors were evaluated. Results Pharmacokinetic studies identified extensive non-tumor reduction of PR-104A to the 5-amine PR-104H (identity of which was confirmed by chemical synthesis), especially in liver. However, high concentrations of PR-104H in tumors that suggested intra-tumor ...
Creative-Proteomics offer cas 106-51-4 1,4-BENZOQUINONE (D4, 98%). We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
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ریشه-زایی گیاه می-تواند ناشی از تلقیح میکروبی و اکسین میکروبی باشد. تولید اکسین توسط باکتری-ها با ایفای نقش در ریشه-زایی گیاه به عنوان یکی از ویژگی-های تحریک‌کننده رشد گیاه شناخته می-شود. بر این اساس در قالب آزمایش فاکتوریل، توان تولید اکسین برخی از جدایه-های باکتریایی (25 جدایه) در شرایط درون-شیشه‌ای مورد سنجش قرار گرفت. نتایج نشان داد که تولید اکسین جدایه-ها در شرایط درون شیشه-ای، در حضور و عدم حضور تریپتوفان (به عنوان پیش ماده تولید اکسین) در محیط NF، از 75/0 تا 28/2 میلی-گرم بر لیتر متغیر بود. بالاترین میزان تولید اکسین متعلق به جدایه Az-3 بود و کمترین میزان در
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Definition of antibody-directed enzyme prodrug therapy in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is antibody-directed enzyme prodrug therapy? Meaning of antibody-directed enzyme prodrug therapy as a legal term. What does antibody-directed enzyme prodrug therapy mean in law?
In this report, we detail Substrate Mediated Enzyme Prodrug Therapy (SMEPT) as a novel approach in drug delivery which relies on enzyme-functionalized cell culture substrates to achieve a localized conversion of benign prodrug(s) into active therapeutics with subsequent delivery to adhering cells or adjacent tissues. For proof-of-concept SMEPT, we use surface adhered micro-structured physical hydrogels based on poly(vinyl alcohol), β-glucuronidase enzyme and glucuronide prodrugs. We demonstrate enzymatic activity mediated by the assembled hydrogel samples and illustrate arms of control over rate of release of model fluorescent cargo. SMEPT was not impaired by adhering cells and afforded facile time - and dose - dependent uptake of the in situ generated fluorescent cargo by hepatic cells, HepG2. With the use of a glucuronide derivative of an anticancer drug, SN-38, SMEPT afforded a decrease in cell viability to a level similar to that achieved using parent drug. Finally, dose response was achieved using
Three 2,4,6-trinitrotoluene (TNT) nitroreductases from Klebsiella sp. C1 have different reduction capabilities that can degrade TNT by simultaneous utilization of two initial reduction pathways. Of these, nitroreductase II was purified to homogeneity by sequential chromatographies. Nitroreductase II...
Looking for online definition of 1,4-benzoquinone in the Medical Dictionary? 1,4-benzoquinone explanation free. What is 1,4-benzoquinone? Meaning of 1,4-benzoquinone medical term. What does 1,4-benzoquinone mean?
A novel cascade reaction involving oxidative dearomatization/semipinacol rearrangement of indol-2-yl cyclobutanols is explored with N-sulfonyloxaziridine (Davis oxaziridines) as oxidant, generating various 2-spiroquaternary 3-oxindoles in modest to good yields. This method might be useful in the synthesis of indole-based alkaloids bearing 2-spiroquaternary carbon centers. PTS=p-toluenesulfonic acid monohydrate. ...
1003 Lavendamycin is a bacterially derived quinolinedione that displays significant antimicrobial and antitumor activities. NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that has been implicated in the bioactivation of antitumor quinones. NQO1 is overexpressed in some tumors relative to uninvolved tissues suggesting that antitumor lavendamycins that are bioactivated by NQO1 may be selectively toxic to those tumors. We examined the metabolism of a series of novel lavendamycin analogues by recombinant human NQO1 and their cytotoxicity to human colon adenocarcinoma cells with either no detectable NQO1 activity (BE-WT) or with high NQO1 activity (BE-NQ). Twenty-one novel lavendamycins were studied as potential antitumor agents focusing on the effects of functional group changes on reduction efficiency by NQO1. Lavendamycin reduction was monitored using a spectrophotometric assay in which the rate of reduction of cytochrome c was quantified at 550 nm. Substituents at the ...
5-nitraquine: DNA-affinic hypoxic cell radiosensitizer & bioreductive agent; RN given refers to parent cpd; structure given in first source
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As the appreciation for anaerobic bacteriology has grown, it has become apparent that the isolation of Bacteroides species from clinical isolates is a significant finding. Studies by Redondo et al. (15) and Nguyen et al. (14) have linked Bacteroides bacteremia to higher mortality rates, which can be further affected by the use of inactive antimicrobials in the treatment regimen.. The class of 5-nitroimidazole drugs (metronidazole, tinidizole, and ornidizole) exerts antimicrobial actions via inhibition of DNA synthesis (19). This action requires intracellular reduction of the nitro group of these prodrugs to produce reactive radical species. Although the 5-nitroimidazole drugs were introduced into clinical practice in 1960, resistance of B. fragilis to these drugs was not described until 1978 (10) and remains rare (1, 20-22). The first metronidazole-resistant Bacteroides isolates were found to have altered end products of glucose metabolism that conferred distinctive biochemical and growth ...
0064] Numerous chemotherapeutic agents (antineoplastic agents) have been developed for treating cancer. In the clinic, depending on cancer diagnosis, different antineoplastic agents are preferred. Antineoplastic agents used for treating cancers, or under investigation for use in treating cancers, may include, but are not limited to: (1) nitrogen mustards, such as mechlorethamine, cyclophosphamide, ifosfamide, melphalan (L-sarcolysin, L-PAM), uramustine, and chlorambucil; (2) ethylenimines and methylmelamines (aziridines), such as thioTEPA, hexamethylmelamine (HMM, altretamine), and triethylenemelamine (TEM); (3) nitrosoureas, such as carmustine (BCNU), lomustine (CCNU), semustine (Methyl-CCNU), fotemustine, and streptozotocin; (4) alkyl sulfonates, such as busulfan; (5) azines and hydrazines (triazenes), such as dacarbazine (DTIC) and procarbazine (MATULANE®); (6) platins, such as cisplatin, carboplatin and oxaliplatin; (7) pteridines, such as methotrexate; (8) pyrimidine analogs, such as ...
Guise,C.P., Abbattista,M., Singleton,R.S., Holford,S.D., Connolly,J., Dachs,G.U., Fox,S.B., Pollock,R., Harvey,J., Guilford,P., Doñate,F., Wilson,W.R., Patterson,A.V. The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3. Cancer Res., in press. Gu, Y., Atwell, G.J. and Wilson,W.R. Metabolism and excretion of the novel bioreductive prodrug PR-104 in mice, rats, dogs and humans. Drug Metab. Dispos., in press doi:10.1124/dmd.109.030973. Jameson, M.B., Rischin, D., Pegram, M., Gutheil, J., Patterson, A.V., Denny, W.A. and Wilson, W.R. A phase I pharmacokinetic trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-ketoreductase 1C3, in patients with solid tumors. Cancer Chemother Pharmacol. Published online 10 Dec 09. DOI 10.1007/s00280-009-1188-1. Gu,Y. and Wilson, W.R. Rapid and sensitive ultra-high-pressure liquid chromatography-tandem mass spectrometry analysis of the novel anticancer agent PR-104 and its major ...
Using cyclic voltammetry, the electrochemistry of aqueous solutions of 4-methoxy-1,2-benzoquinone was investigated over the pH range 0-8. From the variation of half-wave potential with pH, it was inferred that the quinone was reduced to the hydroquinone; no acid-base reactions involving either the quinone or hydroquinone were observed. At low pH ( , 3), the cyclic voltammogram of the benzoquinone changed rapidly to a second pair of peaks at lower potentials. These were shown to be due to 2-hydroxy-1,4-benzoquinone, formed by hydrolysis of the original compound. The other hydrolysis product, methanol, was detected chromatographically. The hydrolysis reaction was shown to be first order both with respect to the 1,2-benzoquinone and protons. At pH 6 and above, 4-methoxy-1,2-benzoquinone showed a second type of decomposition whose rate was approximately first order in hydroxide ion. Using electrochemical and spectroscopic measurements, it was also demonstrated that 4-methoxy-1,2-benzoquinone was ...
Glucose is abundant in nature and can be found in various sources. In this study, we developed multifunctional carbon dots (CDs) with glucose and poly(ethyleneimine) (PEI), which were further quaternized using a facile approach. The CDs are designed to possess both anti-bacteria and gene delivery capabilities. The Chemistry for Medicine: Special Collection for RSC Advances
Proton Motion within Proton-Bound Dimers: H3O(+) .H2O ,=, H2).H3)(+), NH4(+).NH3 ,=, NH3.NH4(+) and CH5(+).CH4 ,=, CH4.CH5(+). A Kinetic Model for Isotope-Exchange Reactions," Int. J. Mass Spectrom. Ion Processes 1991, 109, 105; with D. Smith and N.G. Adams.. "Isotope-Exchange Reactions as a Function of Temperature: Isotopic Fractionation in Interstellar Molecules," In Chemistry and Spectroscopy of Interstellar Molecules, D.K. Bohme, E. Herbst, N. Kaifu and S. Saito, Eds., University of Tokyo Press: Tokyo, 1992, pp. 251-253; with J.F. Paulson.. "Gas-Phase Reactions of Weak Brønsted Bases II(-), PO3(-), HSO4(-), FSO3(-), CF3SO3H. with Strong Brønsted Acids H2SO4, FSO3H, CF3SO3H. A Quantitative Intrinsic Superacidity Scale for the Sulfonic Acids XSO3H (X = HO, F, CF3)" J. Am. Chem. Soc. 1992, 114, 4299; with A.A. Viggiano, F. Dale, C.A. Deakyne and J.F. Paulson.. "Rate Constants and Their Temperature Dependences. A Kinetic Description Using Simple Model Potential-Energy Surfaces," Angew. Chem., ...
Banoxantrone is a highly selective bioreductive drug that is activated in, and is preferentially toxic to, hypoxic cells in tumours. It has been shown to work synergistically with fractionated radiation to significantly delay growth of tumours compared to administration of either banoxantrone or radiation alone. Banoxantrone was also efficacious in tumour models when administered in combination with either cisplatin or chemoradiation. (PMID: 10864207)
A highly efficient and CO tolerant PtRu electrocatalysts supported on amino-rich, cationicpoly(ethyleneimine) polyelectrolyte functionalized multi-walled carbon nanotubes (PtRu/PEI-MWCNTs)has been developed. The catalysts were characterized by thermogravimetric analysis, Raman spectroscopy, cyclic voltammograms, CO stripping, chronoamperometry, transmission electron microscopy (TEM) and X-ray diffraction (XRD). The PtRu particles with average size ~2.5 nm are well dispersed on PEI-MWCNTs. The peak current for the methanol oxidation reaction on 40% PtRu/PEI-MWCNTs is 636 mA mg-1 Pt , 5.7 times higher than 112 mA mg-1 Pt measured on the 40% PtRu supported on acid treated MWCNTs (PtRu/AO-MWCNTs) under identical conditions. PtRu/PEI-MWCNTs catalysts exhibit a superior electrocatalytic activity and stability for the methanol oxidation reaction due to its high tolerance toward CO poisoning as compared with PtRu/AO-MWCNTs for direct methanol fuel cells.. ...
Chemotherapy of leishmaniasis is principally predicated on antimonials. and 13e werent dangerous against fibroblasts, macrophages, or dendritic cells. Jointly, these results claim that the aziridine-2,3-dicarboxylates 13b and 13e are potential antileishmanial business lead substances with low toxicity against web host cells and selective antiparasitic results. Chemotherapy against leishmaniasis is situated generally on antimony substances, initially defined in 1912 by Vianna (42) in Brazil as trivalent antimonials [Sb(III)]. These substances display high toxicity and a small therapeutic window, conditions that led to the introduction of the pentavalent antimonium [Sb(V)] agencies sodium stibogluconate (Pentostam) and meglumine antimoniate (Glucantime), presented around 1940 (31, 38). Pentavalent antimonium substances display a wider healing window and therefore became the medications of preference against leishmaniasis. Nevertheless, their toxicity causes critical unwanted effects that PXD101 ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
This invention relates to a support for oligonucleotide synthesis and more particularly to a necleoside-linker/polymer support composite having the general formula P--S wherein P is a polymer support which bears oxirane, aziridine or episulfide groups or which contains good leaving groups for nucleophilic displacement; and S is a nucleoside-linker having the general formula W--(CH.sub.2).sub.a --X--(CH.sub.2).sub.b --Y--(CH.sub.2).sub.c --Z wherein W and Z each independently comprise a nucleophile; X and Y which, independently may or may not be present, comprise groups of high hydrophilicity; and a, b, c are integers from 0 to 9, wherein a plus b plus c exceeds 6.
The diaziridiny/benzoquinone RH1 is shortly to enter a phase I clinical trial. The drug was originally designed as a substrate for the enzyme DT-diaphorase (DTD) such that metabolic activation of the drug would lead to toxicity. To evaluate this, we have measured the toxicity of RH1 in a pair of non-small cell lung cancer (NSCLC) cell lines of widely differing levels of DTD and in MDA231 breast cancer cells which have been engineered to overexpress DTD. In addition, we have explored the importance of the putative one-electron reductase, P450 reductase, by assessing the toxicity of RH1 in MDA231 cells engineered to overexpress the enzyme. All drug exposures were carried out under hypoxic and aerobic conditions. Those cells with the highest levels of DTD, i.e. D7 versus MDA231 wt and H460 versus H596, are substantially more sensitive to RH1 than the cell lines expressing low DTD activity. Those cells with the lowest levels of DTD activity, i.e. MDA231 wt, R4 and H596, show much greater sensitivity ...
1,4-Benzoquinone 常見於的活性的結構分子中,亦被廣泛地運用在藥物結構修飾。 在化學反應上,1,4-benzoquinone 較常進行的是親核基取代反應,藉由這一類的反應能 導入不同的基團,經常能提升化合物的生物活性。然而,此類的親核基取代反應對於 取代在 C2或 C3位置,並無太大的選擇性。為了提高化學選擇性、清楚了解取代基位 置對於生物活性的影響,本計畫將以兩類具 1,4-benzoquinone結構的 quinoline-5,8-dione 及天然物 denbinobin 作為探討對象,利用離去基導向、溫度控制及路易士酸輔助等方 法,提高親核基取代反應的位向選擇性,合成一系列的 2-aroyl-quinoline-5,8-dione 及 denbinobin 衍生物,初步的實驗數據顯示 2-aroyl-quinoline-5,8-dione 及 denbinobin 衍生 物接具有良好的癌細胞生長抑制效果,因此本計畫將持續探討不同取代基對於活性的 影響,同時計畫合成各式 ...
PA 824: nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial F420-depedent glucose-6-phosphate dehydrogenase (Fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis; structure in first source
Li, L.; Jiang, Y.; Zeng, C-C; Hu, L-M.; Tian, H-Y.; Lam, C. M.; Little, R. D. Aromatic C-H bond functionalization induced by electrochemically in situ generated tris(p-bromophenyl)aminium (TBPA) radical cation: cationic chain reactions of electron-rich aromatics with enamides, J. Org. Chem. 2015, 80(21), 11021-11030; DOI: 10.1021/acs.joc.5b02222. • Chen, J.; Yan, W-Q.; Lam, M.; Zeng, C-C.; Hu, L-M.; Tian, H-Y.; Little, R.D. Electrocatalytic Aziridination of Alkenes Mediated by n-Bu4NI: A Radical Pathway Org. Lett. 2015, http://dx.doi.org/10.1021/acs.orglett.5b00083. • Yoo, S. J.; Li, Long-Ji; Zeng, C-C.; Little, R. D. Polymeric Ionic Liquid and Carbon Black Composite as a Reusable Supporting Electrolyte: Modification of the Electrode Surface, Angewandte Chemie, Int. Ed. 2015, http://dx.doi.org/10.1002/anie.201410207 in the International Edition and http://dx.doi.org/10.1002/ange.201410207 in the German Edition.. • Gbur, R. K.; Little, R. D. Electrosynthesis of Bioactive Materials, in ...
Product Details of P-Benzoquinone CAS 106-51-4 Benzoquinone p-Benzoquinone P-quinone PBQ Quinone, P-Benzoquinone CAS 106-51-4 Benzoquinone p-Benzoquinone P-quinone PBQ Quinone from China manufacturer on Hisupplier.com.
The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
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You are viewing an interactive 3D depiction of the molecule (2s,3r,4r,5s)-2-(hydroxymethyl)-1-pentyl-3,4,5-piperidinetriol (C11H23NO4) from the PQR.
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Communications DOI: 10.1002/anie.201100706 Organocatalysis Cinchona Alkaloid Amide Catalyzed Enantioselective Formal [2+2] Cycloadditions of Allenoates and Imines: Synthesis of 2,4-Disubstituted Azetidines** Jean-Baptiste Denis, Graldine Masson,* Pascal Retailleau, and Jieping Zhu* Chiral azetidines[1] represent an important class of fourmembered nitrogen heterocycles that have a wide range of synthetic applications,[1-3] remarkable biological activities,[1, 4] and are prevalent in natural products.[1, 5] However, in contrast to the homologous small-ring saturated nitrogen heterocycles such as aziridines, pyrrolidines, and piperidines, the synthetic approaches to enantiomerically enriched azetidines are few in number and are generally multistep processes.[1, 6, 7] Among the different synthetic routes, the formal [2+2] cycloaddition[8] is certainly one of the most powerful methods for the construction of the strained four-membered ring. However, only a few catalytic enantioselective methods have ...
The authors have used a covalently attaching antiestrogen, tamoxifen aziridine TA to analyze the structure and dynamics of the estrogen receptor in MCF-7 human breast cancer cells. The labeling of receptor with (/sup 3/H)TA is specific, being blocked only by estrogens and antiestrogens, and the labeling is very efficient in that TA labels covalently the same number of receptors that are labeled reversibly by estradiol. In cells exposed to (/sup 3/H)TA for 1 h, most of the covalently associated radioactivity is found in the 0.6 M KCl extract of the nuclear fraction; this receptor has an apparent mol wt of 63,000 +/- 2000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and a pI of 5.7 by gel isoelectric focusing in the presence of 8 M urea. The mol wt and pI of cytosol receptor labeled with (/sup 3/H) TA are identical. In cells labeled with (/sup 3/H)TA (20 nM) for 1 h and then exposed to a chase of 10(-6) M estradiol, (3H)TA-labeled nuclear receptor disappears with a half-life of 4 ...
THE Philippine Drug Enforcement Agency (PDEA) on Thursday morning destroyed P2.67 billion worth of dangerous drugs at the Integrated Waste Management, Inc. (IWMI), Barangay Aguado, Trece Martirez City, Cavite.. Destroyed through thermal decomposition were a total of 1,677,021.07 grams, or 1.6 metric tons of assorted pieces of drug evidence composed of methamphetamine hydrochloride ("shabu"), liquid shabu, ketamine, marijuana, ephedrine, aziridine, norephedrine, pseudoephedrine, and expired medicines.. PDEA said thermal decomposition is the process by which various compounds are broken down into single units by the application of heat wherein reconstruction of the substances is impossible.. "Majority of the burned shabu were seized from two storage facilities in San Fernando, Pampanga on September 12, 2014," PDEA Director General Arturo Cacdac Jr. said. ...
The place of prodrugs in the current antitubercular therapeutic arsenal is preponderant, since two of the four first-line antitubercular agents, isoniazid (INH) and pyrazinamide (PZA), need to be activated by Mycobacterium tuberculosis before exerting their activity. In addition, six other prodrugs can be found in the second- and third-line therapeutic regimens. The emergence of mycobacterial strains resistant to one or several antitubercular agents is one of the main issues of the antitubercular therapy. In the case of prodrugs, the resistance phenomenon is often related to a mutation in the gene encoding for the activation enzymes, resulting thus in a default of these enzymes that are no more able to activate prodrugs ...
Acid Showdown! The first catalytic ring expansion of vinyl oxetanes to 3,6-dihydro-2H-pyrans is described. Copper(II) triflate emerged as the best catalyst for this new transformation, which has broad scope as demonstrated by the eighteen examples included. The symmetric vinyl oxetane substrate can be asymmetrically desymmetrized when using either chiral Lewis or Brønsted acids as catalysts. ...
All experimentally characterized proteins in this family are 1,4-benzoquinone reductases. These are intracellular enzymes involved in the biodegradation of aromatic compounds and in the protection of fungal cells from reactive quinone compounds ...
I thought Id start a thread for those lovely bubhubbers who are baby dancing in december. DH and I have just decided that we will be trying for number 3 :smiliedance:We fell quickly with DS (first month) and DD (second month of gender - page 32
Gaussian process (GP) models are a flexible means of performing nonparametric Bayesian regression. However, GP models in healthcare are often only used to model a single univariate output time series, denoted as single-task GPs (STGP). Due to an increasing prevalence of sensors in healthcare settings, there is an urgent need for robust multivariate time-series tools. Here, we propose a method using multitask GPs (MTGPs) which can model multiple correlated multivariate physiological time series simultaneously. The flexible MTGP framework can learn the correlation between multiple signals even though they might be sampled at different frequencies and have training sets available for different intervals. Furthermore, prior knowledge of any relationship between the time series such as delays and temporal behavior can be easily integrated. A novel normalization is proposed to allow interpretation of the various hyperparameters used in the MTGP. We investigate MTGPs for physiological monitoring with synthetic

Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel...Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel...

CHIRAL AZIRIDINES, 1-ALKYL-2-(BROMOMETHYL)AZIRIDINES, CHEMOTHERAPY, EPOXIDES, POTENT, ASSAY, IONS. journal title EUROPEAN ... CHIRAL AZIRIDINES,1-ALKYL-2-(BROMOMETHYL)AZIRIDINES,CHEMOTHERAPY,EPOXIDES,POTENT,ASSAY,IONS}, language = {eng}, number = {2}, ... Aziridinium salts, Aziridines, Ring opening, Triaminopropanes, Antimalarial agents, INTERMEDIATE AZIRIDINIUM SALTS, PLASMODIUM- ... Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel ...
more infohttps://biblio.ugent.be/publication/1234402

ChemIDplus - 68307-89-1 - Aziridine, homopolymer, reaction products with epichlorohydrin - Similar structures search, synonyms,...ChemIDplus - 68307-89-1 - Aziridine, homopolymer, reaction products with epichlorohydrin - Similar structures search, synonyms,...

Aziridine, homopolymer, reaction products with epichlorohydrin - Similar structures search, synonyms, formulas, resource links ... Substance Name: Aziridine, homopolymer, reaction products with epichlorohydrin. RN: 68307-89-1. Classification Codes. *. TSCA ...
more infohttps://chem.nlm.nih.gov/chemidplus/rn/68307-89-1

Aziridine - WikipediaAziridine - Wikipedia

Aziridines are organic compounds containing the aziridine functional group, a three-membered heterocycle with one amine group ... Alkene + DPH → R h 2 ( C O 2 R ) 4 {\displaystyle {\xrightarrow {Rh_{2}(CO_{2}R)_{4}}}} Aziridine For instance, Ph-Aziridine-Me ... Respiratory sensitiser - causing occupational asthma Binary ethylenimine, a dimeric form of aziridine "Aziridine" (PDF). Re- ... although sharing the general characteristics of aziridines. As electrophiles, aziridines are subject to attack and ring-opening ...
more infohttps://en.wikipedia.org/wiki/Aziridine

Aziridine synthesisAziridine synthesis

Adducts derived from P(NMe2)3 and α-ketoesters are effectively intercepted by N-sulfonyl imines, affording a range of aziridine ... A mild, convenient protocol for the synthesis of cis-aziridines employs a catalytic amount of Br nsted acid. Diazo compound ... The tertiary amine DABCO catalyzes the reaction of imines with phenacyl bromide derivatives to afford functionalized aziridines ... PF6 to produce the corresponding aryl aziridine carboxylates in high yields with excellent cis-diastereoselectivity.. J. S. ...
more infohttp://www.organic-chemistry.org/synthesis/C1N/aziridines3.shtm

Aziridine, 1-(1-propenyl)-, (E)Aziridine, 1-(1-propenyl)-, (E)

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
more infohttps://webbook.nist.gov/cgi/inchi/InChI%3D1S/C5H9N/c1-2-3-6-4-5-6/h2-3H%2C4-5H2%2C1H3/b3-2%2B

AgOTf-catalyzed dehydrative [3+2] annulation of aziridines with 2-naphthols - Chemical Communications (RSC Publishing)AgOTf-catalyzed dehydrative [3+2] annulation of aziridines with 2-naphthols - Chemical Communications (RSC Publishing)

The reaction of 2-naphthols with aziridines in the presence of AgOTf resulting in a dehydrative, formal [3+2] annulation is ... A preliminary study on the mechanism of this reaction indicates an SN1-type ring-opening of aziridines. This method is ... AgOTf-catalyzed dehydrative [3+2] annulation of aziridines with 2-naphthols T. Kaicharla, A. Jacob, R. G. Gonnade and A. T. ... The reaction of 2-naphthols with aziridines in the presence of AgOTf resulting in a dehydrative, formal [3+2] annulation is ...
more infohttp://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc03425c

Leicester Research Archive: Aziridines : stereocontrol of ring-making and ring-breakingLeicester Research Archive: Aziridines : stereocontrol of ring-making and ring-breaking

The C-4 carbonyl oxygen of the quinazolinone (Q*) was found to participate in the aziridine ring-opening under some conditions ... Finally, the sense of regioselectivity in the ring-opening of the methyl acrylate-derived aziridine can be changed by forming a ... Thus Q* as a substituent on nitrogen was found to be sufficiently electron-withdrawing to activate the aziridine ring towards ... The two N-invertomers of the indene-derived aziridine were separately ring-opened by hydrogen chloride with very different ...
more infohttps://lra.le.ac.uk/handle/2381/30090

Molecules | Free Full-Text | Short and Efficient Synthesis of Optically Active N-Tosyl Aziridines from 2-Amino AlcoholsMolecules | Free Full-Text | Short and Efficient Synthesis of Optically Active N-Tosyl Aziridines from 2-Amino Alcohols

Two alternative and complementary one-pot procedures for the direct transformation of 2-amino alcohols to N-tosyl aziridines ... Short and Efficient Synthesis of Optically Active N-Tosyl Aziridines from 2-Amino Alcohols. Lothar W. Bieber * and Maria C. F. ... Bieber, L.W.; De Araújo, M.C.F. Short and Efficient Synthesis of Optically Active N-Tosyl Aziridines from 2-Amino Alcohols. ... Two alternative and complementary one-pot procedures for the direct transformation of 2-amino alcohols to N-tosyl aziridines ...
more infohttp://www.mdpi.com/1420-3049/7/12/902

Ficellomycin: an aziridine alkaloid antibiotic with potential therapeutic capacity | Springer for Research & DevelopmentFicellomycin: an aziridine alkaloid antibiotic with potential therapeutic capacity | Springer for Research & Development

Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus, which displays high in vitro activity against Gram- ... Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus, which displays high in vitro activity against Gram- ... Ittah Y, Sasson Y, Shahak I, Tsaroom S, Blum J (1978) A new Aziridine synthesis from 2-azido alcohols and tertiary phosphines. ... Ismail F, Levitsky D, Dembitsky V (2009) Aziridine alkaloids as potential therapeutic agents. Eur J Med Chem 44(9):3373-3387 ...
more infohttps://rd.springer.com/article/10.1007/s00253-018-8934-4

A novel and selective fluoride opening of aziridines by XtalFluor-E. synthesis of fluorinated diamino acid derivatives. | Sigma...A novel and selective fluoride opening of aziridines by XtalFluor-E. synthesis of fluorinated diamino acid derivatives. | Sigma...

A novel and selective fluoride opening of aziridines by XtalFluor-E. synthesis of fluorinated diamino acid derivatives.. [ ... The method based on the selective aziridine opening by fluoride has been generalized to afford access to mono- or bicyclic ... or cyclohexane carboxylate has been developed through a novel and efficient fluoride opening of an activated aziridine ring ... proceeded through a stereoselective aziridination of the olefinic bond of a bicyclic lactam and regioselective aziridine ring ...
more infohttps://www.sigmaaldrich.com/catalog/papers/25686276

DE19753456A1 - Two-component cationically-curable aziridine polyol:ether-based composition 
        - Google PatentsDE19753456A1 - Two-component cationically-curable aziridine polyol:ether-based composition - Google Patents

160-5000 and a cationic polymerization retarding agent(s). A two-component cationically-curable aziridine polyether-based ... and an aziridine salt(s) of an acid, and a base component including a mixture of N-alkylaziridine polyol ethers with imino ... composition comprises: (1) a catalyst component comprising: (a) 0.01-50 wt.% acid(s); (b) 0.01-99.5 wt.% aziridine salt(s) of ... A two-component cationically-curable aziridine polyether-based composition comprises a catalyst component, including an acid(s ...
more infohttps://patents.google.com/patent/DE19753456A1/en

Occupational Asthma and Contact Dermatitis in a Spray Painter after Introduction of an Aziridine Cross-Linker.Occupational Asthma and Contact Dermatitis in a Spray Painter after Introduction of an Aziridine Cross-Linker.

... ... Occupational asthma and contact dermatitis in a spray painter after introduction of an aziridine cross-linker. Environmental ... dermatitis and respiratory difficulty characterized by small airways obstruction shortly after the polyfunctional aziridine ...
more infohttps://dash.harvard.edu/handle/1/4595270

Reactivity of activated versus nonactivated 2-(bromomethyl)aziridines with respect to sodium methoxide: a combined...Reactivity of activated versus nonactivated 2-(bromomethyl)aziridines with respect to sodium methoxide: a combined...

However, ring opening was found to be only feasible for the epoxide and the activated aziridine, and not for the nonactivated ... However, ring opening was found to be only feasible for the epoxide and the activated aziridine, and not for the nonactivated ... CHIRAL AZIRIDINES, FREE-ENERGY. journal title JOURNAL OF ORGANIC CHEMISTRY. J. Org. Chem.. volume. 76. issue. 21. pages. 8698 ... 2011). Reactivity of activated versus nonactivated 2-(bromomethyl)aziridines with respect to sodium methoxide: a combined ...
more infohttps://biblio.ugent.be/publication/1943629

Aziridine, 1-(1,1-dimethylethoxy)-2,2,3-trimethyl-,Aziridine, 1-(1,1-dimethylethyl)-2,3-diphenyl-, cis- Suppliers &...Aziridine, 1-(1,1-dimethylethoxy)-2,2,3-trimethyl-,Aziridine, 1-(1,1-dimethylethyl)-2,3-diphenyl-, cis- Suppliers &...

Comprehensive supplier list for Aziridine, 1-(1,1-dimethylethoxy)-2,2,3-trimethyl-,Aziridine, 1-(1,1-dimethylethyl)-2,3- ... Aziridine,1-(3-pyridinylcarbonyl)- (9CI); Aziridine, 1-nicotinoyl- (8CI);1-(3-Pyridinecarbonyl)aziridine Molecular Formula: C8H ... AZIRIDINE, 1-(1-PROPENYL)-, (E)- (6 suppliers). IUPAC Name: 1-[(E)-prop-1-enyl]aziridine , CAS Registry Number: 80839-91-4. ... AZIRIDINE, 1-(1-CYCLOHEXEN-1-YL)- (7 suppliers). IUPAC Name: 1-(cyclohexen-1-yl)aziridine , CAS Registry Number: 153616-85-4. ...
more infohttp://www.chemicalregister.com/Companies/AName/Page1058/aidA.htm

Treating blood or blood products with compounds which have a mustard,     azirdinium or aziridine group and a nucleic acid...Treating blood or blood products with compounds which have a mustard, azirdinium or aziridine group and a nucleic acid...

"Oligomers of aziridines and N-beta-aziridinoethylamides" Bull. of the Acad. of Sci. of USSR 37(11 part2): 2315-2323 (1988)... ... The method according to claim 1, wherein the moiety is an aziridine.. 17. The method according to claim 1, wherein the blood ... The method according to claim 21, wherein the moiety is an aziridine.. 37. The method according to claim 21, wherein the blood ... The method according to claim 41, wherein the moiety is an aziridine.. 56. The method according to claim 41, wherein the blood ...
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CAS No.71243-81-7,Hexanedioic acid, polymer with N-(2-aminoethyl)-1,2-ethanediamine and aziridine, reaction products with...CAS No.71243-81-7,Hexanedioic acid, polymer with N-(2-aminoethyl)-1,2-ethanediamine and aziridine, reaction products with...

where to buy 71243-81-7(Hexanedioic acid, polymer with N-(2-aminoethyl)-1,2-ethanediamine and aziridine, reaction products with ... 2-ethanediamine and aziridine, reaction products with epichlorohydrin and polyethylene glycol) including MSDS sheet(poisoning, ... 2-ethanediamine and aziridine, reaction products with epichlorohydrin and polyethylene glycol) for price inquiry. ... Hexanedioic acid, polymer with N-(2-aminoethyl)-1,2-ethanediamine and aziridine, reaction products with epichlorohydrin and ...
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a Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type ... Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type ... Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type ... "Asymmetric Synthesis of Α,β-diamino Acid Derivatives with an Aziridine-, Azetidine- and Γ-lactone-skeleton via Mannich-type ...
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Risk Management Plan (RMP) Facilities for Chemical : Propyleneimine  [Aziridine, 2-methyl-], Level of Detail : SummaryRisk Management Plan (RMP) Facilities for Chemical : Propyleneimine [Aziridine, 2-methyl-], Level of Detail : Summary

This search was done on November 16, 2018. It was compiled from government data last released on April 30, 2018. The data were obtained from the U.S. EPAs Risk Management System database (RMP).. ...
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NAVER Academic | Aziridines: epoxides ugly cousins?NAVER Academic | Aziridines: epoxides' ugly cousins?

In addition to descriptions of the physical nature of aziridines, especially those features which underpin their utility as ... reactions and utility of aziridines exists; this review briefly summarizes the similarities and differences between oxiranes ... Aziridines, the nitrogenous analogues of epoxides, have until recently excited far less interest amongst synthetic organic ... and their nitrogenated analogues, concentrating on the underlying properties of aziridines and recent developments in their ...
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Aziridine Industry & Polyoxyalkyleneamines and Isobornyl Acrylate Market 2014 ReportsAziridine Industry & Polyoxyalkyleneamines and Isobornyl Acrylate Market 2014 Reports

... ... Also covered, is manufacturers data on listed Global and China Aziridine Market production capacity, market share, production ... The influence of Aziridine industry policy is discussed in this research along with product specifications, manufacturing ... Statistics of global and Chinas key Aziridine manufacturers with their capacity of production, cost, price, profit, production ...
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Aziridine C2H5N structure | Essay Writing Service A+Aziridine C2H5N structure | Essay Writing Service A+

Aziridine C2H5N structure. Let us write you a custom essay sample on ... 1986) ECOSAR Class Program (ECOSAR v0.99h): Class(es) found: Aziridines Henrys Law Constant (25 deg C) [HENRYWIN v3.10]: Bond ...
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Laser flash photolysis of aziridines. Spectroscopic and kinetic characterization of azomethine ylides. Their [3+2] cyclization...Laser flash photolysis of aziridines. Spectroscopic and kinetic characterization of azomethine ylides. Their [3+2] cyclization...

The reactive intermediates generated by laser flash photolysis (lambda(exc) = 248 or 193 nm) of the aziridines (E)-1-butyl-2,3- ... Gaebert C, Siegner C, Mattay J, Toubartz M, Steenken S. Laser flash photolysis of aziridines. Spectroscopic and kinetic ... Gaebert, C, Siegner, C, Mattay, Jochen, Toubartz, M, and Steenken, S. "Laser flash photolysis of aziridines. Spectroscopic and ... Gaebert, C., Siegner, C., Mattay, J., Toubartz, M., Steenken, S.: Laser flash photolysis of aziridines. Spectroscopic and ...
more infohttps://pub.uni-bielefeld.de/publication/2402455

N -bromosuccinimide-induced aminocyclization-aziridine ring-expansion cascade: An asymmetric and highly stereoselective...N -bromosuccinimide-induced aminocyclization-aziridine ring-expansion cascade: An asymmetric and highly stereoselective...

Zhou, J., Yeung, Y.-Y. (2014-04-18). N -bromosuccinimide-induced aminocyclization-aziridine ring-expansion cascade: An ... A novel N-bromosuccinimide induced aminocyclization-aziridine ring expansion cascade is reported. Substituted azepanes were ... N -bromosuccinimide-induced aminocyclization-aziridine ring-expansion cascade: An asymmetric and highly stereoselective ...
more infohttp://scholarbank.nus.edu.sg/handle/10635/94337
  • According to these computational analyses, the synthesis of chiral 2-substituted 1-tosylaziridines can take place with inversion (through ring opening/ring closure) or retention (through direct bromide displacement) of configuration upon treatment of the corresponding 2-(bromomethyl)aziridines with 1 equiv of a nucleophile, whereas chiral 2-substituted 1-benzylaziridines are selectively obtained with retention of configuration (via direct bromide displacement). (ugent.be)
  • A convenient synthesis of chiral nonracemic vinyl aziridines. (naver.com)
  • An amine functional group displaces the adjacent halide in an intramolecular nucleophilic substitution reaction to generate an aziridine. (wikipedia.org)
  • The Hoch-Campbell ethylenimine (Aziridine) synthesis is the reaction of certain oximes with Grignard reagents: In 2014, a new method was described to produce aziridines by reacting a mono-, di-, tri- or tetra- substituted alkene (olefin) with O-(2,4-dinitrophenyl)hydroxylamine (DPH) via homogeneous rhodium catalysis, alone. (wikipedia.org)
  • Alkene + DPH → R h 2 ( C O 2 R ) 4 {\displaystyle {\xrightarrow {Rh_{2}(CO_{2}R)_{4}}}} Aziridine For instance, Ph-Aziridine-Me can be synthesyzed by this method and then converted by ring opening reaction to (D)-amphetamine and (L)-amphetamine (the two active ingredients in Adderall). (wikipedia.org)
  • The reaction of N -tosyl imines with in situ generated iodomethyllithium, with a simple and rapid experimental protocol, allows an efficient and general synthesis of aziridines. (organic-chemistry.org)
  • Montmorillonite K-10 as solid acid catalyzes a stereoselective reaction of imines with ethyl diazoacetate to yield cis -aziridines. (organic-chemistry.org)
  • The reaction of 2-naphthols with aziridines in the presence of AgOTf resulting in a dehydrative, formal [3+annulation is reported. (rsc.org)
  • A preliminary study on the mechanism of this reaction indicates an S N 1-type ring-opening of aziridines. (rsc.org)
  • Aldimines (generated in situ from aldehydes and amines) react readily with ethyl diazoacetate in the presence of 2 mol% of Bi(OTf) 3 in [bmim]PF 6 to produce the corresponding aryl aziridine carboxylates in high yields with excellent cis -diastereoselectivity. (organic-chemistry.org)
  • Laser flash photolysis of aziridines. (uni-bielefeld.de)
  • The reactive intermediates generated by laser flash photolysis (lambda(exc) = 248 or 193 nm) of the aziridines (E)-1-butyl-2,3-diphenylaziridine 1, (E)-2,3-diphenylaziridine 2, 1,2-dliphenylaziridine 3, 1-(p-methoxyphenyl)-2-phenylaziridine 4 and 1-butyl-2-phenylaziridine 5 in acetonitrile and alcohols as solvents were identified as the corresponding azomethine ylides and spectroscopically and kinetically characterized. (uni-bielefeld.de)
  • Statistics of global and China's key Aziridine manufacturers with their capacity of production, cost, price, profit, production value, gross margin and other details are provided. (ireachcontent.com)
  • The bond angles in aziridine are approximately 60°, considerably less than the normal hydrocarbon bond angle of 109.5°, which results in angle strain as in the comparable cyclopropane and ethylene oxide molecules. (wikipedia.org)
  • Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus , which displays high in vitro activity against Gram-positive bacteria including multidrug resistant strains of Staphylococcus aureus . (springer.com)
  • An antagonistic effect between aziridine and diaziridine on their cyto" by S Takase, M Watanabe et al. (jax.org)
  • An antagonistic effect between aziridine and diaziridine on their cytotoxic activities against l-1210 mouse leukemia cells. (jax.org)
  • Occupational Asthma and Contact Dermatitis in a Spray Painter after Introduction of an Aziridine Cross-Linker. (harvard.edu)
  • De Araújo, M.C.F. Short and Efficient Synthesis of Optically Active N-Tosyl Aziridines from 2-Amino Alcohols. (mdpi.com)
  • This research lists upstream raw materials, equipments and down stream clients' survey analysis as well as Aziridine Industry marketing channels and industry development trends and proposals. (ireachcontent.com)
  • In the end, this report introduces a new Aziridine SWOT analysis project with investment feasibility analysis, investment return analysis and offers related research conclusions and development trend analysis on Global and China Aziridine industry. (ireachcontent.com)
  • The two N-invertomers of the indene-derived aziridine were separately ring-opened by hydrogen chloride with very different stereochemistry, mediated by the Q* group. (le.ac.uk)
  • Some aziridines, N-, S- & O-mustards and selenium / this publication represents the views of an IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man, which met in Lyon, 8-14 April 1975. (who.int)