Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.
Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.
Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.
Vinyl compounds, in the context of medical materials, refer to synthetic polymers made from vinyl chloride or vinyl acetate monomers, which are used in the production of various medical devices and supplies such as blood bags, intravenous (IV) bags, tubing, and gloves due to their flexibility, transparency, and resistance to chemicals and heat.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Assaying potential carcinogens with Drosophila. (1/274)

Drosophila offers many advantages for the detection of mutagenic activity of carcinogenic agents. It provides the quickest assay system for detecting mutations in animals today. Its generation time is short, and Drosophila is cheap and easy to breed in large numbers. The simple genetic testing methods give unequivocal answers about the whole spectrum of relevant genetic damage. A comparison of the detection capacity of assays sampling different kinds of genetic damage revealed that various substances are highly effective in inducing mutations but do not produce chromosome breakage effects at all, or only at much higher concentrations than those required for mutation induction. Of the different assay systems available, the classical sex-linked recessive lethal test deserves priority, in view of its superior capacity to detect mutagens. Of practical importance is also its high sensitivity, because a large number of loci in one fifth of the genome is tested for newly induced forward mutations, including small deletions. The recent findings that Drosophila is capable of carrying out the same metabolic activation reactions as the mammalian liver makes the organism eminently suitable for verifying results obtained in prescreening with fast microbial assay systems. An additional advantage in this respect is the capacity of Drosophila for detecting short-lived activation products, because intracellular metabolic activation appears to occur within the spermatids and spermatocytes.  (+info)

Inhibition of DNA replicon initiation by 4-nitroquinoline 1-oxide, adriamycin, and ethyleneimine. (2/274)

The effects of three widely differing chemical carcinogens, 4-nitroquinoline 1-oxide, Adriamycin, and ethyleneimine, on DNA replication were studied by pulse labeling of DNA with [3H]thymidine and sedimentation analysis with alkaline sucrose gradients. At doses that reduced the rate of DNA synthesis to 30 to 60% of control values, only ethyleneimine produced damage that resulted in lower molecular weights of parental DNA. All three chemicals inhibited replicon initiation, but to differing extents. Inhibition of replicon initiation was the first clearly identified effect of 4-nitroquinoline 1-oxide and was the main cause of inhibition of DNA synthesis. Ethyleneimine caused severe inhibition of replicon initiation, but blocks to chain elongation also contributed significantly to the inhibition of overall DNA synthesis. Adriamycin affected replicon initiation to a small but significant extent; the primary cause of inhibition of DNA synthesis by this drug was a slowing of the rate of chain elongation. These results indicate that inhibition of replicon initiation is an important mechanism for the action of DNA-damaging agents in mammalian cells and strengthen the concept that control of DNA replication depends on the structural integrity of a chromosomal subunit that consists of several replicons.  (+info)

Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954. (3/274)

Expression of the E. coli enzyme nitroreductase (NTR) in tumour cells enables them to activate the prodrug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide), leading to interstrand DNA crosslinking and cell death. Using transfected or retrovirally transduced SKOV3 ovarian carcinoma cell clones, we show a strong correlation between sensitivity to CB1954 and level of NTR enzyme activity. Importantly for clinical application in ovarian cancer, a cisplatin-resistant ovarian tumour cell line remains as susceptible to the NTR-dependent cytotoxicity of CB1954 as parental cells. In mixed populations of NTR-expressing and non-expressing cells, we observe a marked 'bystander killing' effect with this system. The use of NTR-encoding retroviruses from clonal producer cell lines at titres of 5 x 10(5) c.f.u./ml to transduce either established or low passage primary ovarian carcinoma lines only achieves an average 10-fold sensitisation of the cultures at gene transfer efficiencies of 15-25%. Concentration of the retrovirus to 3 x 10(7) c.f.u./ml elevates gene transfer to 80-90% in a single exposure to target cells, resulting in up to 500-fold sensitisation of the entire, unselected SKOV3 population to CB1954. In an initial investigation of NTR/CB1954 for the treatment of tumours in vivo, we observe regression of tumours expressing NTR following administration of CB1954, resulting in significantly increased median survival.  (+info)

Spermine inhibition of the 2,5-diaziridinyl-1,4-benzoquinone (DZQ) crosslinking reaction with DNA duplexes containing poly(purine). poly(pyrimidine) tracts. (4/274)

Upon reduction, 2,5-diaziridinyl-1,4-benzoquinone (DZQ) can form an interstrand guanine to guanine crosslink with DNA duplexes containing a d(GC).d(GC) dinucleotide step. The reaction is enhanced by a thymine positioned 5[prime] to each guanine [i.e. in a d(TGCA). d(TGCA) duplex fragment]. Here we show that spermine can inhibit DZQ crosslink formation in duplexes of sequence d[C(N6)TGCA(M6)C]. d[G(M[prime]6)TG-CA(N[prime]6)G]. For N6= M6= GGGGGG, N6= M6= a 'random' sequence and N6= GGGGGG and M6= a 'random' sequence, spermine concentrations of 20, 1 and 3 microM, respectively, were required for 50% inhibition of the DZQ crosslink. This suggests that spermine is more strongly bound to the polyguanosine tract than the random sequence, making it less available for crosslink inhibition. When the polyguanosine tract is interrupted by N 7-deazaguanine (D) located three bases, d(CGGGDGGTGCAGGDGGGC), and four bases, d(CG-GDGGGTGCAGGGDGGC), from the d(TGCA).d(TGCA) site, 30 and 3 microM spermine, respectively, were required for 50% crosslink inhibition. We suggest that this difference is due to the relative proximity of the three-guanosine tract to the d(TGCA).d(TGCA) site. We were able to confirm these conclusions with further experiments using duplexes containing three-guanosine and two-guanosine tracts and from computer simulations of the spermine-DNA complexes.  (+info)

Occupational asthma and contact dermatitis in a spray painter after introduction of an aziridine cross-linker. (5/274)

A 23-year-old spray painter developed contact dermatitis and respiratory difficulty characterized by small airways obstruction shortly after the polyfunctional aziridine cross-linker CX-100 began to be used in his workplace as a paint activator. The symptoms resolved after he was removed from the workplace and was treated with inhaled and topical steroids. Painters may have an increased risk of asthma due to exposure to a variety of agents, such as isocyanates, alkyd resins, and chromates. This case illustrates the importance of using appropriate work practices and personal protective equipment to minimize exposure. Occupational asthma is diagnosed by a history of work-related symptoms and exposure to known causative agents. The diagnosis is confirmed by serial pulmonary function testing or inhalational challenge testing. The risk of asthma attributable to occupational exposures is probably underappreciated due to underreporting and to inappropriate use of narrow definitions of exposure in epidemiologic studies of attributable risk.  (+info)

Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling. (6/274)

The molecular basis of the interaction of DT-diaphorase with a cytotoxic nitrobenzamide CB1954 [5-(aziridin-1-yl)-2, 4-dinitrobenzamide] and five inhibitors was investigated with wild-type DT-diaphorase (human and rat) and five mutants [three rat mutants (rY128D, rG150V, rH194D) and two human mutants (hY155F, hH161Q)]. hY155F and hH161Q were generated to evaluate a hypothesis that Tyr155 and His161 participate in the obligatory two-electron transfer reaction of the enzyme. The catalytic properties of hY155F and hH161Q were compared with a naturally occurring mutant, hP187S. Pro187 to Ser mutation disturbs the structure of the central parallel beta-sheet, resulting in a reduction of the binding affinity of the flavin-adenine dinucleotide prosthetic group. With NADH as the electron donor and menadione as the electron acceptor, the k(cat) values for the wild-type human DT-diaphorase, hY155F, hH161Q, and hP187S were measured as 66 +/- 1, 23 +/- 0, 5 +/- 0 and 8 +/- 2 x 10(3) min(-1), respectively. Because hY155F still has significant catalytic activity, the hydroxyl group on Tyr155 may not be as important as proposed. Interestingly, hY155F was found to be 3. 3 times more active than the human wild-type DT-diaphorase in the reduction of CB1954. Computer modeling based on our results suggests that CB1954 is situated in the active site, with the aziridinyl group pointing toward Tyr155 and the amide group placed near a hydrophobic pocket next to Tyr128. Dicoumarol, Cibacron blue, chrysin, 7,8-dihydroxyflavone, and phenindone are competitive inhibitors of the enzyme with respect to nicotinamide coenzymes. The binding orientations of dicoumarol, flavones, and phenindone in the active site of DT-diaphorase were predicted by results from our inhibitor-binding studies and computer modeling based on published X-ray structures. Our studies generated results that explain why dicoumarol is a potent inhibitor and binds differently from flavones and phenindone in the active site of DT-diaphorase.  (+info)

Effects of aluminum potassium sulfate on learning, memory, and cholinergic system in mice. (7/274)

AIM: To study the relationship between aluminum potassium sulfate (APS) and memory deficits of mice. METHODS: 30, 60, or 90 d after the mice were given daily APS i.g., the step-through latency (STL) was determined with a passive avoidance task. Aluminum (Al) contents in brain and blood were assayed with atomic absorption spectrophotometry. Acetylcholine (ACh) content in brain was determined with chemiluminescent method and choline acetyltransferase (ChAT) activity was measured radiochemically. RESULTS: APS 1 g.kg-1 increased blood-Al only after 30 d. After 60 d, STL, ACh content and ChAT activity decreased by 46.4%, 8.5%, and 22.6%, respectively. These parameters decreased by 50%, 11.1%, and 27.8%, respectively, with increased Al in blood and brain, after 90 d. APS 0.25 g.kg-1 had no effects on mice except blood-Al. In ethylcholine mustard aziridium chloride (AF64A) treated mice, APS 1 g.kg-1 only increased blood and brain-Al. CONCLUSION: The intake of APS 1 g.kg-1.d-1 for 60 d induced learning and memory deficits in mice.  (+info)

Nitroreductase-mediated cell ablation is very rapid and mediated by a p53-independent apoptotic pathway. (8/274)

Nitroreductase (NTR)-mediated selective cell ablation using the prodrug CB1954 has been achieved in vivo by targeting the nitroreductase gene to the luminal cells of the mammary gland in transgenic mice. We report that the cell ablation occurs very rapidly, starting as early as 7 h after administration of the prodrug. By cross-breeding the BLG-NTR transgenic mice to a p53-deficient mouse strain, we have generated BLG-NTR transgenic mice on a p53 null background and tested NTR-mediated cell ablation in these mice. The transgenic mice lacking a functional p53 gene showed cell ablation at a similar level compared with p53 wild-type transgenic mice, showing that functional p53 is not required for CB1954-NTR mediated cell death. These results provide further support for using this system in anti-cancer therapy.  (+info)

Aziridines are a class of organic compounds that contain a three-membered ring consisting of two carbon atoms and one nitrogen atom. The nitrogen atom is bonded to two alkyl or aryl groups, and the third carbon atom is bonded to a hydrogen atom or another organic group.

Aziridines are important intermediates in the synthesis of various pharmaceuticals, agrochemicals, and other industrial chemicals. They can be prepared by the reaction of alkyl or aryl halides with nitrogen nucleophiles such as ammonia or primary amines, followed by intramolecular cyclization.

Aziridines are also useful building blocks in organic synthesis due to their high reactivity towards various nucleophilic reagents. They can undergo ring-opening reactions with a wide range of nucleophiles, including water, alcohols, amines, and carboxylic acids, leading to the formation of new carbon-heteroatom bonds.

It is important to note that aziridines themselves are toxic and should be handled with care. However, their derivatives have found significant applications in medicinal chemistry as antitumor agents, anti-inflammatory drugs, and enzyme inhibitors.

Alkadienes are organic compounds that contain two carbon-carbon double bonds in their molecular structure. The term "alka" refers to the presence of hydrocarbons, while "diene" indicates the presence of two double bonds. These compounds can be classified as either conjugated or non-conjugated dienes based on the arrangement of the double bonds.

Conjugated dienes have their double bonds adjacent to each other, separated by a single bond, while non-conjugated dienes have at least one methylene group (-CH2-) separating the double bonds. The presence and positioning of these double bonds can significantly affect the chemical and physical properties of alkadienes, including their reactivity, stability, and spectral characteristics.

Alkadienes are important intermediates in various chemical reactions and have applications in the production of polymers, pharmaceuticals, and other industrial products. However, they can also be produced naturally by some plants and microorganisms as part of their metabolic processes.

Azirines are a class of heterocyclic organic compounds that contain a three-membered ring consisting of two carbon atoms and one nitrogen atom. The structure of azirines can be represented by the chemical formula C2H2NR, where R is a hydrogen atom or a functional group.

Azirines are highly strained molecules due to the small size of the ring, which makes them reactive and useful in organic synthesis. They can undergo various reactions, such as cycloaddition, to form larger and more complex molecules. Azirines have been found to exhibit biological activity and are being investigated for their potential use in medicinal chemistry.

It is important to note that azirines are not a medical term per se, but rather a chemical term used to describe a specific class of organic compounds.

"Vinyl compounds" is not a term used in medical definitions. It is a term used in chemistry and materials science to refer to a group of chemicals that contain carbon-based molecules with a vinyl group, which is a functional group consisting of a double bond between two carbon atoms, with one of the carbons also being bonded to a hydrogen atom (-CH2=CH-).

Vinyl compounds are used in various industrial and consumer products, including plastics, resins, adhesives, and coatings. Some vinyl compounds, such as polyvinyl chloride (PVC), have been used in medical devices and supplies, such as intravenous (IV) bags, tubing, and blood vessel catheters. However, the use of PVC and other vinyl compounds in medical applications has raised concerns about potential health risks due to the release of toxic chemicals, such as phthalates and dioxins, during manufacturing, use, and disposal. Therefore, alternative materials are being developed and used in medical devices and supplies.

Molecular structure, in the context of biochemistry and molecular biology, refers to the arrangement and organization of atoms and chemical bonds within a molecule. It describes the three-dimensional layout of the constituent elements, including their spatial relationships, bond lengths, and angles. Understanding molecular structure is crucial for elucidating the functions and reactivities of biological macromolecules such as proteins, nucleic acids, lipids, and carbohydrates. Various experimental techniques, like X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (cryo-EM), are employed to determine molecular structures at atomic resolution, providing valuable insights into their biological roles and potential therapeutic targets.

Stereoisomerism is a type of isomerism (structural arrangement of atoms) in which molecules have the same molecular formula and sequence of bonded atoms, but differ in the three-dimensional orientation of their atoms in space. This occurs when the molecule contains asymmetric carbon atoms or other rigid structures that prevent free rotation, leading to distinct spatial arrangements of groups of atoms around a central point. Stereoisomers can have different chemical and physical properties, such as optical activity, boiling points, and reactivities, due to differences in their shape and the way they interact with other molecules.

There are two main types of stereoisomerism: enantiomers (mirror-image isomers) and diastereomers (non-mirror-image isomers). Enantiomers are pairs of stereoisomers that are mirror images of each other, but cannot be superimposed on one another. Diastereomers, on the other hand, are non-mirror-image stereoisomers that have different physical and chemical properties.

Stereoisomerism is an important concept in chemistry and biology, as it can affect the biological activity of molecules, such as drugs and natural products. For example, some enantiomers of a drug may be active, while others are inactive or even toxic. Therefore, understanding stereoisomerism is crucial for designing and synthesizing effective and safe drugs.

... are organic compounds containing the aziridine functional group, a three-membered heterocycle with one amine (-NR-) ... Alkene + DPH → R h 2 ( C O 2 R ) 4 {\displaystyle {\xrightarrow {Rh_{2}(CO_{2}R)_{4}}}} Aziridine For instance, Ph-Aziridine-Me ... The De Kimpe aziridine synthesis allows for the generation of aziridines by reacting an α-chloroimine with a nucleophile, such ... which affords aziridines. Aziridines are obtained by treating a mono-, di-, tri- or tetra- substituted alkene (olefin) with O-( ...
... was discovered in 1888 by the chemist Siegmund Gabriel. Its derivatives, also referred to as aziridines, are of ... Aziridine containing compounds also appear to be similarly dangerous. Binary ethylenimine, a dimeric form of aziridine " ... Aziridine is highly toxic with an LD50 of 14 mg (oral, rats). It is a skin irritant. As an alkylating agent, it is also a ... Aziridine is less basic than acyclic aliphatic amines, with a pKa of 7.9 for the conjugate acid, due to increased s character ...
The De Kimpe aziridine synthesis is suitable for both aldimines and ketimines, particularly those with two alkyl substituents ... The De Kimpe azirdine synthesis is a name reaction of organic chemistry, for the generation of aziridines by the reaction of α- ... doi:10.1016/S0040-4020(01)88388-5. "Asymmetric Synthesis of Aziridines by Reduction of N-tert-Butanesulfinyl α-Chloro Imines". ... De Kimpe, Norbert; Moens, Luc (6 February 1990). "Synthesis of 1,2,3-trisubstituted and 1,2,2,3-tetrasubstituted aziridines ...
The Blum-Ittah aziridine synthesis, also known as the Blum-Ittah-Shahak aziridine synthesis or simply the Blum aziridine ... This gives us our desired aziridine and a trialkylphosphine oxide as a side product. The Blum-Ittah aziridine synthesis has ... doi:10.1016/0040-4039(95)00621-I. Fürmeier, Sandra; Metzger, Jürgen O. (2003-01-23). "Fat-Derived Aziridines and Their N- ... "A new aziridine synthesis from 2-azido alcohols and tertiary phosphines. Preparation of phenanthrene 9,10-imine". The Journal ...
The compound is also of interest for the synthesis of dendrimers, a process that exploits the tendency of aziridines to undergo ... It is a secondary amine and the smallest chiral aziridine (ring containing C2N). It is a flammable colorless liquid. Its ... "Aziridines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a03_239.pub2. Global ... Aziridines, All stub articles, Heterocyclic compound stubs). ...
It is used industrially for the synthesis of aziridine itself. The original Wenker synthesis of aziridine itself takes place in ... The Wenker synthesis is an organic reaction converting a beta amino alcohol to an aziridine with the help of sulfuric acid. ... This salt is then reacted with sodium hydroxide in the second step forming aziridine. The base abstracts an amine proton ... Use dmy dates from May 2013, Ring forming reactions, Aziridines, Nitrogen heterocycle forming reactions, Heterocycle forming ...
Branched PEI can be synthesized by the ring opening polymerization of aziridine. Depending on the reaction conditions different ... Steuerle, Ulrich; Feuerhake, Robert (2006). "Aziridines". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. ...
2007). Aziridines and Epoxides in Organic Synthesis. p. 120. ISBN 978-3-527-31213-9. The quinazoline is prepared from the ... With alkenes, nitrenes react to form aziridines, very often with nitrenoid precursors such as nosyl- or tosyl-substituted [N-( ... Watson, Iain D. G.; Yu, Lily; Yudi, Andrei K. (2006). "Advances in Nitrogen Transfer Reactions Involving Aziridines". Acc. Chem ... result in the same trans-aziridine product, suggesting a two-step reaction mechanism. The energy difference between triplet and ...
Aziridines include thiotepa, mytomycin and diaziquone (AZQ). Cisplatin and derivatives include cisplatin, carboplatin and ... The subtypes of alkylating agents are the nitrogen mustards, nitrosoureas, tetrazines, aziridines, cisplatins and derivatives, ...
Aziridine-2,3-dione has an infrared absorption band at 1954 cm−1. The term "oximide" has also been used for oximes. Derivatives ... Its core is a three member heterocycle, aziridine. In 1886 Ost and Mente claimed to produce oximide by the reaction of oxamic ... Derivatives made this way are methyl, isopropyl and phenylethyl-aziridine-2,3-dione. These compounds are unstable at higher ... Aoyama, Hiromu; Sakamoto, Masami; Omote, Yoshimori (September 1980). "Aziridine-2,3-diones". Journal of the American Chemical ...
"Recent Advances in the Stereoselective Synthesis of Aziridines". Chemical Reviews. 114 (16): 7881-7929. doi:10.1021/cr400553c. ...
Note that with aziridines, ring opening can result in a different 1,3-dipole, in which a C-N bond (rather than the C-C bond) ... Cardoso, Ana L.; Pinho e Melo, Teresa M. V. D. (2012). "Aziridines in Formal [3+2]Cycloadditions: Synthesis of Five-Membered ... This is generally done by ring opening of an aziridine, and subsequent trapping by a dipolarophile before the stereochemistry ... Azomethine ylides can be generated from ring opening of aziridines. In accordance with the Woodward-Hoffmann rules, the thermal ...
It is a member of aziridines as well. PubChem. "Triaziquone". pubchem.ncbi.nlm.nih.gov. Retrieved 2023-10-10. Huang CH, Kuo HS ... Aziridines, Alkylating antineoplastic agents, 1,4-Benzoquinones, All stub articles, Antineoplastic and immunomodulating drug ...
... amino alcohols to the corresponding aziridines with diethoxytriphenylphosphorane". The Journal of Organic Chemistry. 51 (1): 95 ...
... ketononestrol aziridine) and antiestrogen (tamoxifen aziridine) in the human estrogen receptor". The Journal of Biological ... "Tamoxifen aziridines: effective inactivators of the estrogen receptor". Endocrinology. 109 (4): 1298-1300. doi:10.1210/endo-109 ...
"Recent Advances in the Stereoselective Synthesis of Aziridines". Chemical Reviews. 114 (16): 7881-7929. doi:10.1021/cr400553c. ...
"Directed Nickel-Catalyzed Negishi Cross Coupling of Alkyl Aziridines". Journal of the American Chemical Society. 135 (36): ...
Polymeric and oligomeric aziridines are one of the moieties used to crosslink waterborne resins. They usually react with the ... Bückmann, A. J. P.; Chen, Q.; Overbeek, G. C.; Stals, P. J. M.; van der Zwaag, D. (2022-09-01). "Polymeric aziridines as benign ...
Aziridine occurs by the cyclization of chloroethylamine; piperazines are formed by cyclization of a two-ethylene unit compound ...
Polyethylenimine is a polymer derived from aziridine. Other synthetic polyamines include 1,3,5-triazinane (not to be confused ...
Cyclopropenes, aziridines and cyclobutanes may be formed in a similar manner. Carbon acids which can be deprotonated by sodium ...
It can also cyclize 2-aminoalcohols to aziridines and to convert α,β-unsaturated carboxylic acids to α,β-unsaturated bromides. ... H. Suzuki; H. Tani (1984). "A mild cyclization of 2-aminoalcohols to aziridines using diphosphorus tetraiodide". Chemistry ...
... (BEI) is a preparation of aziridine. It can be produced by heating bromoethylamine hydrobromide or 2- ... v t e (Aziridines, Virucides, All stub articles, Organic chemistry stubs). ...
Additional Methods RajanBabu has evaluated asymmetric aziridine openings with high enantioselectivity using yttrium- and ... "Bimetallic catalysis in the highly enantioselective ring-opening reactions of aziridines". Chem. Sci. 5 (3): 1102-1117. doi: ...
2-amino alcohols and ethers from aziridines and organolithiums". Chem. Commun. Royal Society of Chemistry (RSC) (19): 2234-2235 ...
8, p. 434 Thibodeaux C. J. (2012). "Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis". Chem. Rev. 112 ( ...
It is made from aziridine and mesoporous silica. "Can we make tailpipes that capture CO2?". HowStuffWorks. 2008-05-27. ...
Diastereopure azomethine ylides are generated by electrocyclic ring opening of aziridines, and then rapidly trapped with strong ... Huisgen, Rolf; Scheer, Wolfgang; Huber, Helmut (1967). "Stereospecific Conversion of cis-trans Isomeric Aziridines to Open- ...
It is manufactured by heating aziridine with thiophosphoryl chloride.[citation needed] Thiotepa is indicated for use in ... Aziridines, Cancer treatments, IARC Group 1 carcinogens, Organophosphoric amides, Orphan drugs, Thiophosphoryl compounds). ...
Aziridines are organic compounds containing the aziridine functional group, a three-membered heterocycle with one amine (-NR-) ... Alkene + DPH → R h 2 ( C O 2 R ) 4 {\displaystyle {\xrightarrow {Rh_{2}(CO_{2}R)_{4}}}} Aziridine For instance, Ph-Aziridine-Me ... The De Kimpe aziridine synthesis allows for the generation of aziridines by reacting an α-chloroimine with a nucleophile, such ... which affords aziridines. Aziridines are obtained by treating a mono-, di-, tri- or tetra- substituted alkene (olefin) with O-( ...
Aziridine. 151-56-4. KX5075000. Azium. 26628-22-8. VY8050000. Azodrin®. 6923-22-4. TC4375000. ...
... polyfunctional aziridine; N-methyl pyrrolidone; NMP; N-nitrosamines; isocyanates; skin patch testing; allergic contact ... water-based polyurethane paint with polytetrafluoroethylene and a polyfunctional aziridine cross-linker) that is applied to ...
This set contains sp3-silicon and sp3-sulfur atoms and aziridine units also. ...
Een heterocyclische verbinding is een cyclische of polycyclische chemische verbinding waarin twee of meer verschillende elementen voorkomen. De term wordt meestal in de context van de organische chemie gehanteerd. Het gaat hier dan om cyclische verbindingen waarin naast koolstof ook één of meer andere elementen, die heteroatomen worden genoemd, in de ring voorkomen. De belangrijkste en meest voorkomende heteroatomen in deze organische verbindingen zijn stikstof, zuurstof en zwavel. Heterocyclische verbindingen met een aromatisch karakter worden heterocyclische aromatische verbindingen (kortweg: heteroaromaten) genoemd. In de organische chemie vormen de heterocyclische verbindingen een omvangrijke stofklasse. De plaats van de verbindingen in deze stofklasse hangt af van hun heteroatoom en de verzadigingsgraad van de ring. Bekende voorbeelden van heterocyclische verbindingen zijn adenine, cafeïne, furaan, pyridine, theobromine en tetrahydrofuraan. Heterocyclische verbindingen bezitten ...
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 9. Some aziridines, N-, S- and 0- ...
Telescoped synthesis of vicinal diamines via ring-opening of electrochemically generated aziridines in flow M. Laktsevich- ... Telescoped synthesis of vicinal diamines via ring-opening of electrochemically generated aziridines in flow. M. Laktsevich- ...
DP-4 is chemically, (1a-methyl-6-oxo-3-phenoxy-1,1a,6,6a-tetrahydroindeno [1,2-b] aziridine-6a-carbonyl) glycine. In silico ... DP-4 shows a toxicity alert due to the presence of aziridine moiety. ...
Some aziridines, N-, S- & O-mustards and selenium / this publication represents the views of an IARC Working Group on the ...
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Aziridines Azirines Cyclopropanes Diaziridines Oxaziridines Oxiranes Thiiranes Four-Membered Rings. Azetidines Cyclobutanes ... Acridines Anthracenes Azaspirocyclic Compounds Aziridines(Polycyclic) Carbazoles Dibenzofurans Fluorenes Imidazothiazoles ...
Aziridines Azirines Cyclopropanes Diaziridines Oxaziridines Oxiranes Thiiranes Four-Membered Rings. Azetidines Cyclobutanes ... Acridines Anthracenes Azaspirocyclic Compounds Aziridines(Polycyclic) Carbazoles Dibenzofurans Fluorenes Imidazothiazoles ...
Aziridines Azirines Cyclopropanes Diaziridines Oxaziridines Oxiranes Thiiranes Four-Membered Rings. Azetidines Cyclobutanes ... Acridines Anthracenes Azaspirocyclic Compounds Aziridines(Polycyclic) Carbazoles Dibenzofurans Fluorenes Imidazothiazoles ...
Hydroxyethhyl-vegy letek (PEI-Aziridine, homopolymer-Nitro-Amin) ltal ban. » Hydroxyethyl Diphenyl Imidazoline. » ...
... that takes to establish the biodiveristy of future aziridines after each relationship. We are actually that the Taking ... Consumers and the Ipp Report into aziridine slideshow, system substituents; Consumer Law Journal, 10,( 2) pp. Griggs, LD, ...
Genetic Toxicity Evaluation of Aziridine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A14153 Summary Data. * G06 ... Aziridine (151-56-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology ... An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Aziridine (151-56-4). Bacterial ... Aziridine (151-56-4). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8020599 ...
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Aziridines-acid Henrys Law Constant (25 deg C) [HENRYWIN v3.10]: Bond Method : 1.61E-013 atm-m3/mole Group Method: Incomplete ...
Genetic Toxicity Evaluation of Aziridine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A14153 Summary Data. * G06 ... Aziridine (151-56-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology ... An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Aziridine (151-56-4). Bacterial ... Aziridine (151-56-4). DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8020599 ...
Some aziridines, N-, S- & O-mustards and selenium / this publication represents the views of an IARC Working Group on the ... Aziridines -- adverse effects , Azirines -- adverse effects , Mustard compounds -- adverse effects , Selenium -- adverse ...
MeSH Terms: Animals; Antineoplastic Agents/standards; Aziridines/analysis*; Cell Line, Tumor; Drug Stability; Female; Humans; ...
... aziridines and other surprises, Advanced Synthesis & Catalysis, Vol: 362, Pages: 1877-1886, ISSN: 1615-4150 ...
... produced by cationic polymerization of aziridine monomers. It has been established that PEIs with branched structure condense ...
Aziridines / antagonists & inhibitors Actions. * Search in PubMed * Search in MeSH * Add to Search ...
Inherently reactive functional groups (e.g., alpha-haloketones, acid chlorides, or aziridines) are undesirable. ...
1. Novel Class of Proteasome Inhibitors: In Silico and In Vitro Evaluation of Diverse Chloro(trifluoromethyl)aziridines.. Ielo ... 2. Selective noncovalent proteasome inhibiting activity of trifluoromethyl-containing gem-quaternary aziridines.. Ielo L; ...
Wu, B.; Gallucci, J. C.;Parquette, J. R.; Rajanbabu, T. V., "Enantioselective desymmetrization ofmeso-aziridines with TMSN3 or ...
The chemical name for thiotepa is Aziridine, 1,11"-phosphinothioylidynetris-, or Tris (1-aziridinyl) phosphine sulfide. ...
Steric bulk (e.g., mustard rather than aziridine) on the ring can limit the possible binding orientations, and the reducible ...
Aziridines,N0000008213, Butyric Acids,N0000008212, Aminobutyric Acids,N0000008211, Norpregnanes,N0000008210, Oxidoreductases, ...
Aziridines Preferred Term Term UI T004060. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... Aziridines Preferred Concept UI. M0002076. Registry Number. 0. Scope Note. Saturated azacyclopropane compounds. They include ... Aziridines. Tree Number(s). D03.383.097.217. Unique ID. D001388. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D001388 ...
Aziridines Preferred Term Term UI T004060. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... Aziridines Preferred Concept UI. M0002076. Registry Number. 0. Scope Note. Saturated azacyclopropane compounds. They include ... Aziridines. Tree Number(s). D03.383.097.217. Unique ID. D001388. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D001388 ...
Aal Chem specializes in selling isocyantes, aziridines, and TGIC, among other crosslinkers. ...
... aziridine,noun,E0011551,yes poly,polybasic,adj,E0048701,basic,adj,E0012047,yes poly,polybenzimidazole,noun,E0700732, ...
Aziridines - Preferred Concept UI. M0002076. Scope note. Saturated azacyclopropane compounds. They include compounds with ...
That would have been polyfunctional aziridine, used to get the acrylic base to cross-link. Pacific Strong could be used without ...
Aziridine Current Synonym true false 139666016 Azacyclopropane Current Synonym true false Associated Value Sets No associated ...
Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to ...
Terminal aziridine derivatives showed activity and, most notably, selectivity. One of the most active and selective compounds ... Aziridines from alkenyl-ß-D-galactopyranoside derivatives: Stereoselective synthesis and in vitro selective anticancer activity ... In this article, we explore the possible mechanisms involved in the cytotoxicity of this aziridine and evaluate its selective ... A series of new aziridines ß-D-galactopyranoside derivatives were synthesized from alkenyl ß-D-galactopyranosides employing ...
  • The request noted concerns about workers' exposure to a new, two-component, water-based polyurethane paint (water-based polyurethane paint with polytetrafluoroethylene and a polyfunctional aziridine cross-linker) that is applied to automotive/truck rubber seals (vehicle sealing) on the dual durometer (DD) extrusion lines. (cdc.gov)
  • That would have been polyfunctional aziridine, used to get the acrylic base to cross-link. (geometry.net)
  • Occupational asthma and contact dermatitis in a spray painter after introduction of an aziridine cross-linker. (nih.gov)
  • Genetic Toxicity Evaluation of Aziridine in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
  • Some aziridines, N-, S- & O-mustards and selenium / this publication represents the views of an IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man, which met in Lyon, 8-14 April 1975. (who.int)
  • 1. Novel Class of Proteasome Inhibitors: In Silico and In Vitro Evaluation of Diverse Chloro(trifluoromethyl)aziridines. (nih.gov)
  • These results suggest that AzGalp induces bulky DNA adducts, and that cancer cells lacking a functional NER pathway may be particularly vulnerable to the anticancer effects of this aziridine. (bvsalud.org)
  • 2. Selective noncovalent proteasome inhibiting activity of trifluoromethyl-containing gem-quaternary aziridines. (nih.gov)
  • We recently screened a series of new aziridines ß-D-galactopyranoside derivatives for selective anticancer activity and identified 2-methyl-2,3-[N-(4-methylbenzenesulfonyl)imino]propyl 2,3-di-O-benzyl-4,6-O-(S)-benzylidene-ß-D-galactopyranoside (AzGalp) as the most promising compound. (bvsalud.org)
  • In this article, we explore the possible mechanisms involved in the cytotoxicity of this aziridine and evaluate its selective anticancer activity using cancer cells and normal cells from a variety of tissues. (bvsalud.org)