Organic or inorganic compounds that contain the -N3 group.
A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Organic compounds that contain two nitro groups attached to a phenol.
An enzyme that converts ascorbic acid to dehydroascorbic acid. EC 1.10.3.3.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The rate dynamics in chemical or physical systems.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.
A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.19, symbol Pb. (Dorland, 28th)
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Substances that are energetically unstable and can produce a sudden expansion of the material, called an explosion, which is accompanied by heat, pressure and noise. Other things which have been described as explosive that are not included here are explosive action of laser heating, human performance, sudden epidemiological outbreaks, or fast cell growth.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids.
A gas that has been used as an aerosol propellant and is the starting material for polyvinyl resins. Toxicity studies have shown various adverse effects, particularly the occurrence of liver neoplasms.
A membrane or barrier with micrometer sized pores used for separation purification processes.
A process of separating particulate matter from a fluid, such as air or a liquid, by passing the fluid carrier through a medium that will not pass the particulates. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An order of the class Amphibia, which includes several families of frogs and toads. They are characterized by well developed hind limbs adapted for jumping, fused head and trunk and webbed toes. The term "toad" is ambiguous and is properly applied only to the family Bufonidae.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
The presence of bacteria, viruses, and fungi in water. This term is not restricted to pathogenic organisms.

Cross-linking of two beta subunits in the closed conformation in F1-ATPase. (1/2265)

In the crystal structure of mitochondrial F1-ATPase, two beta subunits with a bound Mg-nucleotide are in "closed" conformations, whereas the third beta subunit without bound nucleotide is in an "open" conformation. In this "CCO" (beta-closed beta-closed beta-open) conformational state, Ile-390s of the two closed beta subunits, even though they are separated by an intervening alpha subunit, have a direct contact. We replaced the equivalent Ile of the alpha3beta3gamma subcomplex of thermophilic F1-ATPase with Cys and observed the formation of the beta-beta cross-link through a disulfide bond. The analysis of conditions required for the cross-link formation indicates that: (i) F1-ATPase takes the CCO conformation when two catalytic sites are filled with Mg-nucleotide, (ii) intermediate(s) with the CCO conformation are generated during catalytic cycle, (iii) the Mg-ADP inhibited form is in the CCO conformation, and (iv) F1-ATPase dwells in conformational state(s) other than CCO when only one (or none) of catalytic sites is filled by Mg-nucleotide or when catalytic sites are filled by Mg2+-free nucleotide. The alpha3beta3gamma subcomplex containing the beta-beta cross-link retained the activity of uni-site catalysis but lost that of multiple catalytic turnover, suggesting that open-closed transition of beta subunits is required for the rotation of gamma subunit but not for hydrolysis of a single ATP.  (+info)

Activation of Go-proteins by membrane depolarization traced by in situ photoaffinity labeling of galphao-proteins with [alpha32P]GTP-azidoanilide. (2/2265)

Evidence for depolarization-induced activation of G-proteins in membranes of rat brain synaptoneurosomes has been previously reported (Cohen-Armon, M., and Sokolovsky, M. (1991) J. Biol. Chem. 266, 2595-2605; Cohen-Armon, M., and Sokolovsky, M. (1993) J. Biol. Chem. 268, 9824-9838). In the present work we identify the activated G-proteins as Go-proteins by tracing their depolarization-induced in situ photoaffinity labeling with [alpha32P]GTP-azidoanilide (GTPAA). Labeled GTPAA was introduced into transiently permeabilized rat brain-stem synaptoneurosomes. The resealed synaptoneurosomes, while being UV-irradiated, were depolarized. Relative to synaptoneurosomes at resting potential, the covalent binding of [alpha32P]GTPAA to Galphao1- and Galphao3-proteins, but not to Galphao2- isoforms, was enhanced by 5- to 7-fold in depolarized synaptoneurosomes, thereby implying an accelerated exchange of GDP for [alpha32P]GTPAA. Their depolarization-induced photoaffinity labeling was independent of stimulation of Go-protein-coupled receptors and could be reversed by membrane repolarization, thus excluding induction by transmitters release. It was, however, dependent on depolarization-induced activation of the voltage-gated sodium channels (VGSC), regardless of Na+ current. The alpha subunit of VGSC was cross-linked and co-immunoprecipitated with Galphao-proteins in depolarized brain-stem and cortical synaptoneurosomes. VGSC alpha subunit most efficiently cross-linked with guanosine 5'-O-2-thiodiphosphate-bound rather than to guanosine 5'-O-(3-thiotriphosphate)-bound Galphao-proteins in isolated synaptoneurosomal membranes. These findings support a possible involvement of VGSC in depolarization-induced activation of Go-proteins.  (+info)

Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity. (3/2265)

G protein-coupled receptors are commonly thought to bind their cognate ligands and elicit functional responses primarily as monomeric receptors. In studying the recombinant gamma-aminobutyric acid, type B (GABAB) receptor (gb1a) and a GABAB-like orphan receptor (gb2), we observed that both receptors are functionally inactive when expressed individually in multiple heterologous systems. Characterization of the tissue distribution of each of the receptors by in situ hybridization histochemistry in rat brain revealed co-localization of gb1 and gb2 transcripts in many brain regions, suggesting the hypothesis that gb1 and gb2 may interact in vivo. In three established functional systems (inwardly rectifying K+ channel currents in Xenopus oocytes, melanophore pigment aggregation, and direct cAMP measurements in HEK-293 cells), GABA mediated a functional response in cells coexpressing gb1a and gb2 but not in cells expressing either receptor individually. This GABA activity could be blocked with the GABAB receptor antagonist CGP71872. In COS-7 cells coexpressing gb1a and gb2 receptors, co-immunoprecipitation of gb1a and gb2 receptors was demonstrated, indicating that gb1a and gb2 act as subunits in the formation of a functional GABAB receptor.  (+info)

Resolution of the paradox of red cell shape changes in low and high pH. (4/2265)

The molecular basis of cell shape regulation in acidic pH was investigated in human erythrocytes. Intact erythrocytes maintain normal shape in the cell pH range 6.3-7.9, but invaginate at lower pH values. However, consistent with predicted pH-dependent changes in the erythrocyte membrane skeleton, isolated erythrocyte membranes evaginate in acidic pH. Moreover, intact cells evaginate at pH greater than 7.9, but isolated membranes invaginate in this condition. Labeling with the hydrophobic, photoactivatable probe 5-[125I]iodonaphthyl-1-azide demonstrated pH-dependent hydrophobic insertion of an amphitropic protein into membranes of intact cells but not into isolated membranes. Based on molecular weight and on reconstitution experiments using stripped inside-out vesicles, the most likely candidate for the variably labeled protein is glyceraldehyde-3-phosphate dehydrogenase. Resealing of isolated membranes reconstituted both the shape changes and the hydrophobic labeling profile seen in intact cells. This observation appears to resolve the paradox of the contradictory pH dependence of shape changes of intact cells and isolated membranes. In intact erythrocytes, the demonstrated protein-membrane interaction would oppose pH-dependent shape effects of the spectrin membrane skeleton, stabilizing cell shape in moderately abnormal pH. Stabilization of erythrocyte shape in moderately acidic pH may prevent inappropriate red cell destruction in the spleen.  (+info)

Analysis of the membrane-interacting domains of myelin basic protein by hydrophobic photolabeling. (5/2265)

Myelin basic protein is a water soluble membrane protein which interacts with acidic lipids through some type of hydrophobic interaction in addition to electrostatic interactions. Here we show that it can be labeled from within the lipid bilayer when bound to acidic lipids with the hydrophobic photolabel 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine (TID) and by two lipid photolabels. The latter included one with the reactive group near the apolar/polar interface and one with the reactive group linked to an acyl chain to position it deeper in the bilayer. The regions of the protein which interact hydrophobically with lipid to the greatest extent were determined by cleaving the TID-labeled myelin basic protein (MBP) with cathepsin D into peptides 1-43, 44-89, and 90-170. All three peptides from lipid-bound protein were labeled much more than peptides from the protein labeled in solution. However, the peptide labeling pattern was similar for both environments. The two peptides in the N-terminal half were labeled similarly and about twice as much as the C-terminal peptide indicating that the N-terminal half interacts hydrophobically with lipid more than the C-terminal half. MBP can be modified post-translationally in vivo, including by deamidation, which may alter its interactions with lipid. However, deamidation had no effect on the TID labeling of MBP or on the labeling pattern of the cathepsin D peptides. The site of deamidation has been reported to be in the C-terminal half, and its lack of effect on hydrophobic interactions of MBP with lipid are consistent with the conclusion that the N-terminal half interacts hydrophobically more than the C-terminal half. Since other studies of the interaction of isolated N-terminal and C-terminal peptides with lipid also indicate that the N-terminal half interacts hydrophobically with lipid more than the C-terminal half, these results from photolabeling of the intact protein suggest that the N-terminal half of the intact protein interacts with lipid in a similar way as the isolated peptide. The similar behavior of the intact protein to that of its isolated peptides suggests that when the purified protein binds to acidic lipids, it is in a conformation which allows both halves of the protein to interact independently with the lipid bilayer. That is, it does not form a hydrophobic domain made up from different parts of the protein.  (+info)

Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918. (6/2265)

The acridone carboxamide derivative GG918 (N-{4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-pheny l}-9,10dihydro-5-methoxy-9-oxo-4-acridine carboxamide) is a potent inhibitor of MDR1 P-glycoprotein-mediated multidrug resistance. Direct measurements of ATP-dependent MDR1 P-glycoprotein-mediated transport in plasma membrane vesicles from human and rat hepatocyte canalicular membranes indicated 50% inhibition at GG918 concentrations between 8 nM and 80 nM using N-pentyl-[3H]quinidinium, ['4C]doxorubicin and [3H]daunorubicin as substrates. The inhibition constant K for GG918 was 35 nM in rat hepatocyte canalicular membrane vesicles with [3H]daunorubicin as the substrate. Photoaffinity labelling of canalicular and recombinant rat Mdr1b P-glycoprotein by [3H]azidopine was suppressed by 10 muM and 40 muM GG918. The high selectivity of GG918-induced inhibition was demonstrated in canalicular membrane vesicles and by analysis of the hepatobiliary elimination in rats using [3H]daunorubicin, [3H]taurocholate and [3H]cysteinyl leukotrienes as substrates for three distinct ATP-dependent export pumps. Almost complete inhibition of [3H]daunorubicin transport was observed at GG918 concentrations that did not affect the other hepatocyte canalicular export pumps. The high potency and selectivity of GG918 for the inhibition of human MDR1 and rat Mdr1b P-glycoprotein may serve to interfere with this type of multidrug resistance and provides a tool for studies on the function of these ATP-dependent transport proteins.  (+info)

Influence of bioenergetic stress on heat shock protein gene expression in nucleated red blood cells of fish. (7/2265)

The physiological and biochemical signals that induce stress protein (HSP) synthesis remain conjectural. In this study, we used the nucleated red blood cells from rainbow trout, Oncorhynchus mykiss, to address the interaction between energy status and HSP gene expression. Heat shock (25 degrees C) did not significantly affect ATP levels but resulted in an increase in HSP70 mRNA. Hypoxia alone did not induce HSP transcription in these cells despite a significant depression in ATP. Inhibition of oxidative phosphorylation with azide, in the absence of thermal stress, decreased ATP by 56% and increased lactate production by 62% but did not induce HSP gene transcription. Inhibition of oxidative phosphorylation and glycolysis with azide and iodoacetic acid respectively, decreased ATP by 79% and prevented lactate production, but did not induce either HSP70 or HSP30 gene transcription in these cells. This study demonstrates that a reduction in the cellular energy status will not induce stress protein gene transcription in rainbow trout red blood cells and may, in fact, limit induction during extreme metabolic inhibition.  (+info)

Influence of different types of effectors on the kinetic parameters of suicide inactivation of catalase by hydrogen peroxide. (8/2265)

The effects of cyanide and azide ions (class A), sodium-n-dodecyl sulphate (SDS) and 2-mercaptoethanol (class B), 3-aminotriazole (class C) and NADPH (class D) on the initial activity (ai), inactivation rate constant (ki) and the partition ratio (r) of bovine liver catalase reaction with its suicide substrate, hydrogen peroxide, were studied in 50 mM sodium phosphate buffer, pH 7.0 at 27 degrees C. The above kinetic parameters were determined by processing the progress curve data. In class A, which contains fast and reversible inhibitors of catalase, a proportional decrease in ai and ki was observed by inhibitors, so that the r remained constant. In class B, which contains slow and irreversible inactivators, a decrease in ai and constancy of ki and r were observed when catalase was incubated in the presence of such inactivators for a determined time. In class C, containing effector which can combine with intermediate compound I, ai was relatively unchanged but an increase in ki and a decrease in r were observed. In class D, containing effector which reduces compound I to ferricatalase, ai was not affected significantly but some decrease in ki was detected which was linked with an increase in r. These results demonstrate that different classes of effectors affect the determined kinetic parameters of catalase in various ways. Thus, determination of such parameters by simple kinetic experiments can be carried out for classification of the agents which have an effect on the kinetics of catalase.  (+info)

New redox labelling of DNA by an azido group which can be chemically transformed to nitrophenyltriazole or silenced to phenyltriazole was developed and applied to the electrochemical detection of DNA-protein interactions. 5-(4-Azidophenyl)-2-deoxycytidine and 7-(4-azidophenyl)-7-deaza-2-deoxyadenosine nucleosides were prepared by aqueous-phase Suzuki cross-coupling and converted to nucleoside triphosphates (dNTPs) which served as substrates for incorporation into DNA by DNA polymerase. The azidophenyl-modified nucleotides and azidophenyl-modified DNA gave a strong signal in voltammetric studies, at -0.9 V, due to reduction of the azido function. The Cu-catalyzed click reaction of azidophenyl-modified nucleosides or azidophenyl-modified DNA with 4-nitrophenylacetylene gave nitrophenyl-substituted triazoles, exerting a reduction peak at -0.4 V under voltammetry, whereas the click reaction with phenylacetylene gave electrochemically silent phenyltriazoles. The transformation of the azidophenyl ...
Originally reported by Staudinger and Meyer, azides react readily with triarylphosphines to form the corresponding iminophophoranes. The Staudinger Ligation: A High-Yield, Chemoselective, and Mild Synthetic Method.
Smolinsky, G. and Pryde, G. A. (1971) The chemistry of vinyl azides, in The Azido Group (1971) (ed S. Patai), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470771266.ch10 ...
Define azide. azide synonyms, azide pronunciation, azide translation, English dictionary definition of azide. n. Chemistry The univalent linear group N3, or any compound that contains this group, many of which are explosive. az′i·do′ adj. n 1. any compound...
Cy7 Picolyl Azide is an advanced fluorescent probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site. The chelating effect of picolyl azide moiety to raise the effective concentration of copper at the reaction site is so great that it leads to an increase of signal intensity of up to 40-fold. In addition, the use of Cy7 Picolyl Azide instead of conventional Cy7-Azide allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labelling. In summary, the introduction of a picolyl moiety into an azide probe leads to a substantial increase in the sensitivity of alkyne detection. This will be of special value for the detection of low abundance targets or where significant increase in signal intensity is desired.
76444-18-3 - HZEKZNNVGVLXHW-UYYQOESLSA-N - beta-(4-Azidophenyl)adenylyl-(3-5)-uridine 5-diphosphate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
The abstract is the summary of three different projects all centered around the generalidea of catalysis which is the general theme of research in the Michaelis laboratory. The firstproject focuses on development of a new heterogeneous catalyst for selective catalysis. In theMichaelis lab, we were interested in the potential of nanoparticle catalysts for regioselectivetransformations. We showed that polymer supported ruthenium nanoparticles performed as areliable catalyst for regioselective reduction of azide to amine. In our study of regioselectivereduction of multiple azide containing substrates, we observed that in presence of ourruthenium nanoparticle catalysts, the least sterically hindered azide group reduced to aminefunctional group. The results were complementary to the conventional methods that employtriphenyl phosphine (Staudinger reaction) as the reductant and target the most electronicallyactive azide group.In the second project, we were looking to develop a new class of hetero
It is well-known that azide salts can engage nitriles at elevated temperatures to yield tetrazoles; however, there is continued debate as to the mechanism of the reaction. Density functional theory calculations with the hybrid functional B3LYP have been performed to study different mechanisms of tetrazole formation, including concerted cycloaddition and stepwise addition of neutral or anionic azide species. The calculations presented here suggest a previously unsuspected nitrile activation step en route to an imidoyl azide, which then cyclizes to give the tetrazole. The activation barriers are found to correlate strongly with the electron-withdrawing potential of the substituent on the nitrile ...
The PEG Azide can potentially be reacted with an acetylene moiety (Click reaction) or an arylphosphinederivative, as part of several Staudinger ligation options (see references). It can also be used as a precursor to the amine function in which it can be transformed via reduction with P(Ph)3 ...
cd80 mouse anti human cd80 azide free | order cd80 mouse anti human cd80 azide free | How to use: cd80 mouse anti human cd80 azide free | support help for cd80 mouse
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A two-stage microreactor continuous flow system allows the handling organic azides safely in small hold-up volumes with immediate conversion in the 2nd microreactor. In the 1st microreactor the azide intermediate is formed by nucleophilic substitution.1 The azide intermediate is submitted to Staudinger hydration with triphenylphosphine in a subsequent 2nd microreactor. Notably, it is possible to work with biphasic systems in microreactors. A phase transfer catalyst moderates the initial reaction with efficient mixing by the microreactor. Production capacity of o-Xylylenediamine (711462) in two subsequent glass microreactors exceeds 1 kg per day with an overall yield of 60%. Work-up and isolation of the potentially hazardous intermediate is completely avoided between reaction steps, saving time, money and offering scale-independent safety levels. back to top ...
How to remove azide from antibody - posted in Immunology: Does anybody know how to remove sodium azide from the comercial antiboy solutions? I know there are two ways: dialyzing or exchanging over a column. Could anyone provide more detailed information? Thank you all!
3-Isoxazolecarbonyl azide,5-(fluoromethyl)-/ACM625120083 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Rabbit recombinant monoclonal Histone H2B (yeast) antibody [EPR18094] - BSA and Azide free. Validated in WB, ChIP, PepArr and tested in Saccharomyces cerevisiae, Recombinant fragment.
Gentaur molecular products has all kinds of products like :search , Accu \ Mouse TCR gamma_delta, Clone GL_3, Hamster Mab anti_, azide_free \ ACL7201NA for more molecular products just contact us
Rabbit recombinant monoclonal Histone H4 (mono methyl R92) antibody [EPR21782] - BSA and Azide free. Validated in WB, IHC, Flow Cyt, Dot, ICC/IF and tested in Mouse, Rat, Human.
2-Butenoyl azide, 4-(4-morpholinyl)-4-oxo-3-phenyl- | C14H14N4O3 | CID 71392707 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Anti-Human IL-8 Azide Free: Suitable for Flow Cytometry intra-cytoplamic. Blocks IL-8 induced chemotaxis of human neutrophils
Rabbit Polyclonal Anti-LC3A Antibody - Azide Free. Autophagosome Marker. Validated: WB, IHC-P. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
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Boc-N-Amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. - Mechanism of Action & Protocol.
Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental restoratives Journal Article ...
TY - JOUR. T1 - The traceless Staudinger ligation for indirect 18F- radiolabelling. AU - Carroll, Laurence. AU - Boldon, Sophie. AU - Bejot, Romain. AU - Moore, Jane E.. AU - Declerck, Jérôme. AU - Gouverneur, Véronique. PY - 2011/1/1. Y1 - 2011/1/1. N2 - The Staudinger ligation of phosphine-substituted thioesters with 18F-fluoroethylazide has been successfully applied to access 18F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.. AB - The Staudinger ligation of phosphine-substituted thioesters with 18F-fluoroethylazide has been successfully applied to access 18F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.. UR - http://www.scopus.com/inward/record.url?scp=78650098745&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=78650098745&partnerID=8YFLogxK. U2 - 10.1039/c0ob00564a. DO - ...
Establishment of appropriate cell labeling and tracking method is essential for the development of cell-based therapeutic strategies. Here, we are introducing a new method for cell labeling and tracking by combining etabolic glycoengineering and bioorthogonal chemistry. First, cells were treated with unnatural sugars as Ac4ManNAz, Ac4GalNAz, Ac4GlcNAz to generate unnatural azide groups (-N3) on the surface of the cells. Subsequently, the unnatural azide groups on the cell surface were specifically conjugated with cyclooctyne modified dye or nanoparticles through bioorthogonal copper-free click chemistry. Importantly, bioorthogonal labeling method presented strong signal intensity with relatively low cytotoxicity and the amounts of azide groups and cyclooctyne modified agent could be easily controlled by feeding different amounts of Ac4ManNAz and cyclooctyne modified agent to the cell culture system. In chapter 2, DBCO-Cy5-labeled chondrocytes seeded on 3D scaffold were subcutaneously implanted ...
Looking for online definition of Azides in the Medical Dictionary? Azides explanation free. What is Azides? Meaning of Azides medical term. What does Azides mean?
Photo-activation of the hydrophobic membrane probe 1, 5 iodonaphthylazide (INA) by irradiation with UV light (310-380 nm) results in the covalent modification of transmembrane anchors of membrane proteins. This unique selectivity of INA towards the transmembrane anchor has been exploited to specifically label proteins inserted in membranes. Previously, we have demonstrated that photo-activation of INA in enveloped viruses resulted in the inhibition of viral membrane protein-induced membrane fusion and viral entry into cells. In this study we show that photo-activation of INA in various cell lines, including those over-expressing the multi-drug resistance transporters MRP1 or Pgp, leads to cell death. We analyzed mechanisms of cell killing by INA-UV treatment. The effects of INA-UV treatment on signaling via various cell surface receptors, on the activity of the multi-drug resistance transporter MRP1 and on membrane protein lateral mobility were also investigated. INA treatment of various cell lines
Alfa Aesar™ BLOTTO in PBS, with 0.02% sodium azide 250mL Alfa Aesar™ BLOTTO in PBS, with 0.02% sodium azide Blocking Buffers for Protein Methods
TY - JOUR. T1 - MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes. AU - Er, Jun Cheng. AU - Tang, Mui Kee. AU - Chia, Chee Geng. AU - Liew, Huimin. AU - Vendrell, Marc. AU - Chang, Young-Tae. PY - 2013. Y1 - 2013. N2 - A novel class of triazole-derivatized BODIPY compounds have been synthesized on solid-phase by employing mild reaction conditions based on the copper-catalyzed azide-alkyne cycloaddition. The resulting BODIPY-triazoles exhibited MegaStokes shifts (up to 160 nm) and remarkable environmentally sensitive quantum yield increments that asserted their potential as turn-on fluorescent sensors. Out of a library of 120 compounds, we identified BDC-9 as a fluorescent chemosensor with high sensitivity and remarkable species-selectivity towards human serum albumin. These results validate MegaStokes BODIPY dyes as new fluorophores for the development of environmentally sensitive fluorescent probes.. AB - A novel class of triazole-derivatized BODIPY compounds ...
Severn Biotech, Limited PBS (1X) With sodium 0.1% Azide - Phosphate Buffered Saline 1x PBS with 0.1%w/v Sodium Azide. (1X PBS with Azide)This ubiquitous buffer is supplied with the preservative sodium azide already incorporated into the solution. Supplied 0.2 micron filtered in a ready to use format.For use in immunology, molecular biology and other life science techniques as a storage
Staudinger reaction The Staudinger reaction or Staudinger reduction is a chemical reaction in which the combination of an azide with a phosphine or phosphite
We have synthesized a new class of photoaffinity analogs, 2,3-O-(2,4,6-trinitrophenyl)-8-azido-ATP, -ADP and -AMP (TNP- 8N₃ATP, -ADP and -AMP), and their radiolabeled derivatives, and characterized their interaction with the sarcoplasmic reticulum Ca²⁺-ATPase. The TNP-8N₃-nucleotides were synthesized from ATP in three steps involving bromination in the 8-position of the adenine ring followed by displacement with an azido group and then trinitrophenylation of the resulting 8N₃-nucleotide with TNBS. Inclusion of the oxidizing agent, DTNB, in the final reaction was found to be necessary to prevent reduction of the azido group by the released sulfite anion and also elevated the yield of trinitrophenylation to about 80%. Purity was determined spectrophotometrically, as well as by anion exchange TLC and reversed phase HPLC. In the dark, the compounds were found to display most of the features of the parent TNP-nucleotides and interacted with the Ca²⁺-ATPase in a similar way. When ...
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Pegylation using heterotelechelic poly(ethylene glycol) (PEG) offers many possibilities to create high-performance molecules and materials. A versatile route is proposed to synthesize heterobifunctional PEG containing diverse combinations of azide, amine, thioacetate, thiol, pyridyl disulfide, as well as activated hydroxyl end groups. Asymmetric activation of one hydroxyl end group enables the heterobifunctionalization while applying selective monotosylation of linear, symmetrical PEG as a key step. The azide function is introduced by reacting monotosyl PEG with sodium azide. A thiol end group is obtained by reaction with sodium hydrosulfide. The activation of the hydroxyl end group and subsequent reaction with potassium carbonate/thioacetic acid yields a thioacetate end group. The hydrolysis of the thioester end group by ammonia in presence of 2,2′-dipyridyl disulfide provides PEG pyridyl disulfide. Amine terminated PEG is prepared either by reduction of the azide or by nucleophilic substitution of
Thanks Nick, this is exactly the kind of thing we should get from the safety officer, so that we can use these compounds safely. Rather than dopy comments like 1ml of 0.02% sodium azide is an explosive hazard. Mike. On Wed, 18 Jul 2001, Nick Theodorakis wrote: , In , ,Pine.SGI.4.33.0107182118570.2615940-100000 at mole.bio.cam.ac.uk,, , Michael Witty wrote: , , , ,On Wed, 18 Jul 2001, Warren Gallin wrote: , ,, So if you are flushing azide down a sink with metal plumbing, over a , ,, period of time a nasty explosive will build up in the traps. The poor , ,, plumber who cracks one of them can have a small grenade going off , in , ,, his/her face. This has actually happened, so not a theoretical , ,, consideration at all. , , , ,Dear Warren, , , please let me know about the paper or news report that has , ,described these two kinds of accident. I really am interested in , ,collecting examples of this kind of thing happening. , ,Mike. , , , , This is the closest thing I could find: , , ...
AIM: To investigate the neuroprotective effects of hyperoside (Hyp) on PC12 cells apoptosis induced by sodium azide and the mechanism of action. METHODS: To induce apoptosis, cultured PC12 cells was incubated with sodium azide 20 mmol·L⁻¹ for 3-24 h. Pretreatment with Hyp (0.01, 0.1 or 1 μmol·L⁻¹) for 4 h before sodium azide treatment. Cell viability was measured by MTT assay. The chromatin-specif ...
sample_1: JARID1C, [U-100% 15N], 1 mM; sodium phosphate 50 mM; sodium chloride 50 mM; sodium azide 0.02%; DTT 5 mM. sample_2: JARID1C, [U-13C; U-15N], 1 mM; sodium phosphate 50 mM; sodium chloride 50 mM; sodium azide 0.02%; DTT 5 mM. sample_3: JARID1C, [U-100% 15N], 1 mM; sodium phosphate 50 mM; sodium chloride 50 mM; sodium azide 0.02%; DTT 5 mM. sample_4: JARID1C, [U-13C; U-15N], 1 mM; sodium phosphate 50 mM; sodium chloride 50 mM; sodium azide 0.02%; DTT 5 mM. sample_conditions_1: pH: 6.0; pressure: 1 atm; temperature: 297 K. sample_conditions_2: pH*: 6.0; pressure: 1 atm; temperature: 297 K ...
sample_1: Get5 1 mM; Sgt2, [U-100% 13C; U-100% 15N], 2 mM; Bis-Tris 10 mM; L-arginine 50 mM; L-glutamic acid 50 mM; sodium azide 0.02%; H2O 90%; D2O 10%. sample_2: Get5 1 mM; Sgt2, [U-100% 13C; U-100% 15N], 2 mM; Bis-Tris 10 mM; L-arginine 50 mM; L-glutamic acid 50 mM; sodium azide 0.02%; polyacrylamide 3.5%; H2O 90%; D2O 10%. sample_3: Get5, [U-100% 13C; U-100% 15N], 1 mM; Sgt2 2 mM; Bis-Tris 10 mM; L-arginine 50 mM; L-glutamic acid 50 mM; sodium azide 0.02%; H2O 90%; D2O 10%. sample_4: Get5, [U-100% 13C; U-100% 15N], 1 mM; Sgt2 2 mM; Bis-Tris 10 mM; L-arginine 50 mM; L-glutamic acid 50 mM; sodium azide 0.02%; polyacrylamide 3.5%; H2O 90%; D2O 10%. sample_conditions_1: ionic strength: 0 mM; pH: 6.1; pressure: 1 atm; temperature: 310 K ...
First, the basics. Sodium azide (NaN3) is an odorless white solid that reacts violently with water, acid, or solid metal (lead or copper, for instance)....
[65 Pages Report] Check for Discount on Sodium azide Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
Aryl azides were treated with allenylmagnesium bromide to generate 1,5-disubstituted butynyl 1,2,3-triazoles in a domino fashion, which upon Cu(I) catalyzed 1,3-dipolar cycloaddition with aryl azides afforded novel bis-1,2,3-triazoles in quantitative yields. The final products were analyzed for their antimicrobial activities against a panel of bacterial and fungal strains which revealed the products to be potent antimicrobials.
Azido azetikoa konposatu organiko bat da. Formula kimiko hau du: CH3-COOH (C2H4O2).. Kolorerik gabeko likidoa da. Azido azetikoa ozpinaren osagai nagusia da. Azido ahultzat sailkatzen den arren, kontzentrazio altuetan korrosiboa da, eta gizakiaren larruazalari kalte egin diezaioke.. Azido azetiko sinpleena azido karboxilikoa da. Konposatu garrantzitsua da erreaktiboetan eta industria kimikoan, batez ere zeluloide azetatoa, argazki filma eta polibinil azetatoa ekoizteko. Zuntz sintetikoetan ere erabil daiteke. Etxebizitzetan, diluituta erabiltzen da. Kaltzioa kentzeko (E260) azidotasun erregulatzailetzat eta ongailutzat erabiltzen da.. ...
N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz) is an azide-containing metabolic glycoprotein labeling reagent that can be incorporated into the sialic acid biosynthesis pathway. The azide-modified protein is detected with either fluorescent alkynes or biotin alkyne. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.
Tetranitrogen is a neutrally charged polynitrogen allotrope of the chemical formula N 4 and consists of four nitrogen atoms. The tetranitrogen cation is the positively charged ion, N+ 4, which is more stable than the neutral tetranitrogen and is thus more studied. The structure, stability and properties of these molecules have been of great interest to research scientists in the last ten years.[when?] Polynitrogen compounds have been well known and characterized by chemists for many years. Molecular nitrogen (N 2) was first isolated by Daniel Rutherford in 1772 and the azide ion (N− 3) was discovered by Theodor Curtius in 1890. Discoveries of other related nitrogenous allotypes during the twentieth century include the aromatic molecule pentazole and the radical molecule N• 3. However, none of these complexes could be isolated or synthesized on a macroscopic scale like N 2 and azide; it was not until 1999 that a large scale synthesis was devised for a third nitrogen allotrope, the pentazenium ...
The synthesis and full characterisation of bifunctional β -amino acids that have side chains functionalised with terminal azides (S)-4 and (R)-4 or acetylenes 5 and 6 is reported for the first time. The building blocks incorporate a turn-inducing β -segment and a side chain that can be functionalised further, for example, through copper-catalysed Huisgen cycloaddition. Moreover, the corresponding α-amino acids 1 and 3 have been synthesised and characterised. All amino acid building blocks were of high optical purity as demonstrated by derivatisation and subsequent NMR analysis ...
Nota lepid. 36 (1): The status of Satyrus abramovi var. korlana Staudinger, 1901 (Nymphalidae) StaniSlav K. Korb a/ya 97, Nizhny Novgorod Russia; Received 14 August
Benzoyl azide solution/AFI582616 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
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EXPERIMENTAL. The above experiments was conducted on a C80 at a heating rate of 0,5 K/min between room temperature and 280 °C. 76 mg of sample where placed inside a glass liner perfectly fitting the C80 high pressure measurement cell. The C80 was then cooled down, and the permanent decomposition gases were sent to a gas analyzer cell (FTIR).. RESULTS AND CONCLUSIONS. The complex two-step decomposition of o-trifluoromethyl phenyl azide was studied thanks to a combination of calorimetric, pressure, and evolved gas analysis data. Not only thermal and pressure hazards can be assessed, but also the risks linked with the formation of toxic gases - or straightforward information about decomposition mechanisms. For example, the strange silane - based gas detected by the FTIR was assigned to a reaction between the sample and the glass liner.. ...
Mouse Monoclonal Anti-Mucin 5AC Antibody (45M1) - Azide and BSA Free. Validated: WB, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P, IP, CyTOF-ready. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
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Chlorine azide (ClN3) and bromine azide (BrN3) are extremely sensitive and explosive.[55][56] ... However, the alkali metal azides NaN3 and KN3, featuring the linear N−. 3 anion, are well-known, as are Sr(N3)2 and Ba(N3)2. ... Very pure nitrogen can be prepared by the thermal decomposition of barium azide or sodium azide.[72] ... Nitrides, azides, and nitrido complexes[edit]. Nitrogen bonds to almost all the elements in the periodic table except the first ...
Alkene and azide [3+2] cycloaddition[edit]. Oxanorbornadiene (or another activated alkene) reacts with azides, giving triazoles ... Copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC)[edit]. Main article: Azide alkyne Huisgen cycloaddition ... a b c L. Liang and D. Astruc: "The copper(I)-catalysed alkyne-azide cycloaddition (CuAAC) "click" reaction and its applications ... The classic[11][12] click reaction is the copper-catalyzed reaction of an azide with an alkyne to form a 5-membered heteroatom ...
Chlorine azide (ClN3) and bromine azide (BrN3) are extremely sensitive and explosive.[52][53] ... However, the alkali metal azides NaN3 and KN3, featuring the linear N−. 3 anion, are well-known, as are Sr(N3)2 and Ba(N3)2. ... Very pure nitrogen can be prepared by the thermal decomposition of barium azide or sodium azide.[69] ... This stands in contrast to the well-characterised cationic and anionic polynitrogens azide (N−. 3), pentazenium (N+. 5), and ...
When subjecting the azide to a Brønsted acid, the protonation of the azide activates the basal nitrogen and lowers the bond ... The Stieglitz rearrangement of azides generally profits from a protonic or thermal activation, which can also be combined. In ... An alternative way for the production of protonated organic azides is the nuclophilic addition of hydrazoic acid to a ... Stieglitz rearrangements can also proceed on organic azides with molecular nitrogen as a good leaving group. Those reactions ...
Discovery and development of angiotensin receptor blockers Bräse, Stefan; Banert, Klaus (2010). Organic Azides: Syntheses and ...
The C2N14 molecule is a monocyclic tetrazole with three azide groups with a molecular weight of 220.16 g.mol⁻¹. It has a ... Explosion&Fire (2019-03-03). Azidoazide azide. I make C2N14 in my shed - Ex&F. Klapötke, Thomas M.; Krumm, Burkhard; Martin, ... Another synthesis uses a metathesis reaction between isocyanogen tetrabromide in acetone and aqueous sodium azide. This first ... Lowe, Derek (9 January 2013). "Things I Won't Work With: Azidoazide Azides, More Or Less". Science Magazine. American ...
"Trimethylsilyl azide". Organic Syntheses. 50: 107.; Collective Volume, 6, p. 1030 Brook, Michael A. (2000). Silicon in Organic ... trimethylsilyl azide, and trimethylsilyl trifluoromethanesulfonate (TMSOTf). These compounds are produced by a salt metathesis ...
The azidotetrazolate ion can be made from cyanogen bromide and sodium azide in water: BrCN + 2NaN3 → N4CN3− + Na+ + NaBr ... Marsh, F. D. (September 1972). "Cyanogen azide". The Journal of Organic Chemistry. 37 (19): 2966-2969. doi:10.1021/jo00984a012 ...
In this paper he measured physical properties of phenyl isocyanate and of diazobenzene-imide (now known as phenyl azide). The ... D. L. Fishel, personal conversations with C. Marvel and A. Pardee (1959). "PHENYL AZIDE , 622-37-7". www.chemicalbook.com. ...
In the laboratory, sodium nitrite can be used to destroy excess sodium azide. 2 NaN3 + 2 NaNO2 + 4 H+ → 3 N2 + 2 NO + 4 Na+ + 2 ... ISBN 978-0-471-23896-6. "Sodium Azide". Hazardous Waste Management. Northeastern University. March 2003. Archived from the ...
The acyl azide is usually made from the reaction of acid chlorides or anydrides with sodium azide or trimethylsilyl azide. Acyl ... Alternatively, the acyl azide can be formed by the direct reaction of a carboxylic acid with diphenylphosphoryl azide (DPPA). ... Hydrazide und Azide organischer Säuren I. Abhandlung" [Hydrazides and azides of organic acids I. paper]. Journal für Praktische ... Heating the azide in ethanol yields the ethyl carbamate via the Curtius rearrangement. Acid hydrolysis yields the amine from ...
... sodium azide and an acyl chloride are combined to quantitatively generate the acyl azide intermediate, and the rest of the ... The scope of this reaction has been extended to reactions of carbonyls with alkyl azides R-N3. This extension was first ... The Schmidt reaction is an organic reaction in which an azide reacts with a carbonyl derivative, usually a aldehyde, ketone, or ... J. H. Boyer & J. Hamer (1955). "The Acid-catalyzed Reaction of Alkyl Azides upon Carbonyl Compounds". J. Am. Chem. Soc. 77 (4 ...
Compounds like lead azide are used to manufacture bullets that explode into shrapnel on impact. Flash powders are used in a ... "Chlorine Azide, CIN3. I1." - Journal of the American Chemical Society (ACS Publications). N.p., n.d. Web. 23 Oct. 2016. ...
"Isolation of primary decomposition products of azides. II. Azidopyrazoles". J. Org. Chem. 35 (7): 2215. doi:10.1021/jo00832a024 ...
The requisite cycloalkylketone is reacted with PhMgBr; 3° alcohol is then reacted with NaN3; azide then reduced with LAH. Then ...
Curtius, Th.; Radenhausen, R. (1895). "Hydrazide und Azide organischer Säuren. X Abhandlung. 35. Ueber Hydrazide substituirter ...
Lead azide: Used in detonators. Sensitive to impact, friction, and static electricity. Thermally and vacuum stable, if dextrin ...
In one study triethylsilane is used in the conversion of a phenyl azide to an aniline: In this reaction ACCN is a radical ... The triethylsilyl free radical then reacts with the azide with expulsion of nitrogen to a N-silylarylaminyl radical which grabs ... "Radical Reduction of Aromatic Azides to Amines with Triethylsilane". J. Org. Chem. 71 (15): 5822-5825. doi:10.1021/jo060824k. ...
Hassner's research group has studied: Regioselective additions of pseudohalogens; Stereochemistry of reactions of azides and ...
Azides and alkynes are other examples of chemical reporters. A bioorthogonal chemical reporter must be incorporated into a ...
Smith, Peter A.S.; Rowe, Charles D.; Bruner, Leonard B. (2007). "Azides and amines from Grignard reagents and tosyl azide". J. ... Upon treatment with sulfonyl azides, a variety of Grignard reagents or enolates may be converted into azides or amines. A ... Reduction of these salts leads to amines, although they also may be converted to azides upon acidic workup with overall ... Addition reactions have employed imines, oximes, azides, azo compounds, and others. A nitrogen bound to both a good electrofuge ...
Finally, addition of sodium azide, in the last reaction of the second one-pot operation, produce the acyl azide (7) without any ... The current production method includes two reaction steps with potentially hazardous azides. A reported azide-free Roche ... The amide group is reprotected as BOC 6 and the azide group converted to the amide 7 by reductive acylation with thioacetic ... The final one-pot operation begins with a Curtius Rearrangement of acyl azide (7) to produce an isocyanate functional group at ...
Pozsgay, Vince; Jennings, Harold J. (1987). "Azide synthesis with stable nitrosyl salts". Tetrahedron Letters. 28 (43): 5091- ...
The ionic compound ammonium azide is also a constitutional isomer of tetrazene. Greenwood, Norman N.; Earnshaw, Alan (1997). ... Isomeric with tetrazine is ammonium azide. Tetrazene explosive, commonly known simply as tetrazene, which is used for ...
Convenient Access to Alkyl Azides". Journal of the American Chemical Society. 127 (23): 8294-8295. doi:10.1021/ja052164r. ISSN ...
Derek Lowe (9 Jan 2013). "Things I Won't Work With: Azidoazide Azides, More Or Less". v t e. ...
2 B(N3)3 + 3 H2O → 6 HN3 + B2O3 Reaction with other azides like sodium azide or lithium azide yields the corresponding ... Fraenk, W.; Klapötke, T. M. (2002). "Recent Developments in the Chemistry of Covalent Main Group Azides.". In Meyer, G.; ... 6 H2 The compound can also be obtained by passing boron tribromide vapor over solid silver azide in high vacuum. BBr3 + 3 AgN3 ... it is the triazido derivative of borane and is a covalent inorganic azide. The high-energy compound, which has the propensity ...
Azo, diazo, azido, hydrazine and azide compounds. esters, sulfate esters, phosphate esters, thiophosphate esters and borate ...
... and producer and user data are given for sodium-azide (26628228), lead-azide (13424469), and hydrazoic-acid (7782798). The ... The azides stimulate the central nervous system and are hypotensive agents; sodium-azide has been used in experimental therapy ... and producer and user data are given for sodium-azide (26628228), lead-azide (13424469), and hydrazoic-acid (7782798). The ... A threshold limit value of 100 parts per billion has been proposed for sodium-azide in air. (Contract No 210-77-0120) ...
... is a nitrogen hydride (CHEBI:35106) hydrogen azide (CHEBI:29449) is conjugate acid of azide anion ... azide anion (CHEBI:40910) is conjugate base of hydrogen azide (CHEBI:29449). ... CHEBI:29449 - hydrogen azide. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ...
Sodium azide exists as an odorless white solid. When mixed with water or an acid it changes rapidly to a toxic gas with a sharp ... Exposure to sodium azide can be fatal.. *METHODS OF DISSEMINATION: *Indoor Air: Sodium azide can be released into indoor air as ... Food: Sodium azide can be used to contaminate food.. *Outdoor Air: Sodium azide can be released into outdoor air as fine ... DESCRIPTION: Sodium azide exists as an odorless white solid. When mixed with water or an acid it changes rapidly to a toxic gas ...
Heavy metal azides, such as lead azide are primary high explosives detonable when heated or shaken. Heavy-metal azides are ... Aryl azides may be prepared by displacement of the appropriate diazonium salt with sodium azide, or trimethylsilyl azide; ... The principal source of the azide moiety is sodium azide. As a pseudohalogen compound, sodium azide generally displaces an ... Some organic and other covalent azides are classified as highly explosive and toxic: inorganic azides as neurotoxins; azide ...
Sodium azide (NaN3) is an odorless white solid that reacts violently with water, acid, or solid metal (lead or copper, for ... Sodium azide (NaN3) is an odorless white solid that reacts violently with water, acid, or solid metal (lead or copper, for ... The azide ion (the three nitrogen molecules) is remarkably unstable, and therefore reacts readily with water, acid, or metal to ... In addition to all of this, sodium azide is also incredibly toxic, reacting to form a gas that is lighter than air and prevents ...
... MSDS Number: S2906 --- Effective Date: 03/18/98. 1. Product Identification. Synonyms: Azide; Azium; Smite CAS No ... Proper Shipping Name: SODIUM AZIDE Hazard Class: 6.1 UN/NA: UN1687 Packing Group: II Information reported for product/size: 5KG ... Proper Shipping Name: SODIUM AZIDE Hazard Class: 6.1 UN/NA: UN1687 Packing Group: II Information reported for product/size: 5KG ... Sodium Azide (26628-22-8) Yes Yes No Yes --------\Federal, State & International Regulations - Part 1\---------------- -SARA ...
... Marianne Leverone , BIO leverone at CHUMA.CAS.USF.EDU Mon Dec 18 09:39:12 EST 1995 *Previous message: Azide & ... Sodium azide inhibits cytochrome c oxidase (electron transport chain). If you stick sodium azide in your medium, E. coli is not ... On 16 Dec 1995, Louis Hom wrote: , Will sodium azide interfere with lacZ color development w/ x-gal? , -- , ...
... leschnitzrd at buvax1.baylor.edu leschnitzrd at buvax1.baylor.edu Wed Mar 17 10:03:11 EST 1993 *Previous message ... We are having some arguments about the concentration of sodium azide to use in sandwich box reservoirs containing PEG or in ...
Sodium azide is a versatile precursor to other inorganic azide compounds, e.g., lead azide and silver azide, which are used in ... Sodium azide increases cyclic GMP levels in brain and liver by activation of guanylate cyclase. Sodium azide solutions react ... The azide anion is very similar in each form, being centrosymmetric with N-N distances of 1.18 Å. The Na+ ion has an octahedral ... Each azide is linked to six Na+ centers, with three Na-N bonds to each terminal nitrogen center. The common synthesis method is ...
How you could be exposed to sodium azide *Following release of sodium azide into water, you could be exposed to sodium azide by ... Where sodium azide is found and how it is used *Sodium azide is best known as the chemical found in automobile airbags. An ... How sodium azide works *The seriousness of poisoning caused by sodium azide depends on the amount, route, and length of time of ... What sodium azide is *Sodium azide is a rapidly acting, potentially deadly chemical that exists as an odorless white solid. ...
The majority of exposures to sodium azide occur by inhalation. Signs and symptoms of sodium azide poisoning include lethargy or ... Biologic: A case in which sodium azide in serum is detected, as determined by a commercial laboratory. ... Environmental: Detection of sodium azide in environmental samples, as determined by FDA. ... exists for sodium azide exposure, or an epidemiologic link exists between this case and a laboratory-confirmed case. ...
azide synonyms, azide pronunciation, azide translation, English dictionary definition of azide. n. Chemistry The univalent ... Related to azide: azine, alkyne, Lead azide, Sodium azide az·ide. (ăz′īd, ā′zīd). n. Chemistry The univalent linear group N3, ... az•ide. (ˈæz aɪd, -ɪd, ˈeɪ zaɪd, ˈeɪ zɪd) n. any compound containing the univalent group NH3, as sodium azide. ... Energetic binders that appear to offer such promising characteristics include azide functional polymers like glycidyl azide ...
... the Department of Commerce published notice of the suspension of its antidumping investigation on sodium azide from Japan (62 ... Sodium Azide From Japan. A Notice by the International Trade Commission on 01/15/1997. ...
PEG azides are ideal starting materials for the synthesis of PEG derivatives via azide-alkyne cycloaddition or Staudinger ... Learn More about PEG Azides. Polyethylene Glycol Building Blocks for PEGylation Click Chemistry" property="og:description"> ... USA Home > Product Directory > Chemical Synthesis > Chemical Biology > Conjugation Chemistry: Azides, Alkynes and Other ... Learn More about PEG Azides. Polyethylene Glycol Building Blocks for PEGylation Click Chemistry" name="description"> ...
Identifier: AZIDE. Lat/Long: 33-12-09.820N / 097-07-19.220W. State Name: TEXAS. Fix Category: Civil. Fix Use: RNAV-WP. ARTCC: ZFW. Pitch: No. Catch: No. Charts: SID. ...
Smolinsky, G. and Pryde, G. A. (1971) The chemistry of vinyl azides, in The Azido Group (1971) (ed S. Patai), John Wiley & Sons ...
In many instances, the reaction sequence regiospecifically ligates azides and t ... A metal catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to give triazoles. ... At 100 mM azide and 200 mM acetylene, the reaction is complete in 12-14 hours. At 2 mM azide and 4 mM acetylene, the reaction ... Then, the product of the first step is ligated with an azide containing molecule by addition of the azide containing molecule ...
... plural sodium azides) 1. (chemistry) a white, crystalline salt, NaN3; it is explosive, and is used in automobile airbags... ... plural sodium azides) 1. (chemistry) a white, crystalline salt, NaN3; it is explosive, and is used in automobile airbags... ... sodium-azide. Noun (plural sodium azides). *(chemistry) a white, crystalline salt, NaN3; it is explosive, and is used in ... "sodium-azide." YourDictionary, n.d. Web. 11 November 2018. ,https://www.yourdictionary.com/sodium-azide,. ...
This is unique source of information on the chemicals manufactured and imported in Europe. It covers their hazardous properties, classification and labelling, and information on how to use them safely.. REACH. ...
This page contains information on the chemical Sodium azide including: 207 synonyms/identifiers; U.S. Code of Federal ... Azide*Azide (N3-) *Azide anion*Azide Bound At Distal Site*Azide Bound To Zinc*Azide ion*Azide ion(1-) *Azide Ion, N3 -*Azide(1 ... Sodium Azide*Sodium azide (Na(N3)) *Sodium azide (NaN3) *Sodium azide [UN1687] [Poison]*Sodium salt of hydrazoic acid*Sodium, ... Azide, negative ion*Azide, sodium*Azimycin (Veterinary) *Azium*Azium (Veterinary) *Azoture de sodium*Azoture de sodium [French] ...
Here, we describe crystal structures of SmChiB complexed with an azide ligand and an O-allyl oxime fragment as a mimic of a ... The Huisgen cycloaddition of azides and alkynes, accelerated by target biomolecules, termed "in situ click chemistry," has been ... The Huisgen cycloaddition of azides and alkynes, accelerated by target biomolecules, termed "in situ click chemistry," has been ... Serratia marcescens Chitinase B complexed with azide inhibitor. *DOI: 10.2210/pdb3WD3/pdb ...
Azides explanation free. What is Azides? Meaning of Azides medical term. What does Azides mean? ... Looking for online definition of Azides in the Medical Dictionary? ... azide. (redirected from Azides). Also found in: Dictionary, Thesaurus, Encyclopedia. az·ide. (azīd), A compound that contains ... Sodium azide (car air bags), zidovudine.. azide. inhibitor of cytochrome c oxidase (or complex IV) of the respiratory electron- ...
... , from the Compendium of Pesticide Common Names, including IUPAC and CAS systematic names, molecular ...
Sodium azide , NaN3 or N3Na , CID 33557 - structure, chemical names, physical and chemical properties, classification, patents ...
Personally, my metal azide requirements are minimal, and very easily satisfied. I can get ... You may not have felt the need for a better synthesis of metal azides. ... This is an interesting one, I wont say near or dear to my heart, but having used silver azide as a prep for lead azide, silver ... You may not have felt the need for a better synthesis of metal azides. Personally, my metal azide requirements are minimal, and ...
Azide Nutrient Pad Sets for Enterococci, 100 NPS in petri dishes, with 100 sterile membranes. Sartorius Nutrient Pad Sets have ...
Yellow emitting fluorescent dye azide, with ,95% purity. Water soluble compound. Join researchers using our high quality ... Water soluble yellow emitting fluorescent dye azide for click chemistry. Brightness and photostability of fluorophore, together ...
Conjugates prepared with the thiol-reactive azide, succinimidyl ester can be detected with an alkyne-containing molecule in a ... The two-step reaction procedure involves a copper-catalyzed triazole formation of an azide and an alkyne. Click reactions have ... Conjugates prepared with the thiol-reactive azide, succinimidyl ester can be detected with an alkyne-containing molecule in a ...
sodium azide, azide, sodium, natriumazid, nemazyd, smite, kazoe, azoture de sodium, sodium azide na n3, hydrazoic acid, sodium ... sodium azide, azide, sodium, natriumazid, nemazyd, smite, kazoe, azoture de sodium, sodium azide na n3, hydrazoic acid, sodium ...
  • This reaction allows azides to serve as protected -NH2 synthons, as illustrated by the synthesis of 1,1,1-tris(aminomethyl)ethane: 3 H2 + CH3C(CH2N3)3 → CH3C(CH2NH2)3 + 3 N2 In the azide alkyne Huisgen cycloaddition, organic azides react as 1,3-dipoles, reacting with alkynes to give substituted 1,2,3-triazoles. (wikipedia.org)
  • Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides", J. Org. (freepatentsonline.com)
  • The Huisgen cycloaddition of azides and alkynes, accelerated by target biomolecules, termed "in situ click chemistry," has been successfully exploited to discover highly potent enzyme inhibitors. (rcsb.org)
  • The patented technology stems from the discovery that, under proper conditions, copper can quickly and reliably catalyze members of two large chemical groups, azides and alkynes. (thefreedictionary.com)
  • Click chemistry focuses mainly on reactions involving azides , a class of nitrogen-containing molecules, and alkynes, a group of hydrocarbons such as acetylene. (thefreedictionary.com)
  • a) Lutz J.-F (2007) 1,3-dipolar cycloadditions of azides and alkynes: a universal ligation tool in polymer and materials science. (springer.com)
  • For use in bio-orthogonal labeling , Chromeo Dyes are offered as click-reactive azides or alkynes. (activemotif.com)
  • Chromeo™ Dye Azides and Alkynes are supplied lyophilized and should be stored at the recommended temperature in the dark. (activemotif.com)
  • Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry. (harvard.edu)
  • When stereoelectronic amplification is achieved by optimal positioning of σ-acceptors at the endocyclic bonds antiperiplanar to the breaking alkyne π-bonds, the stabilization of the bent alkyne geometry leads to a significant decrease in strain in cyclic alkynes without compromising their reactivity in alkyne-azide cycloadditions. (biomedsearch.com)
  • The molecular structure, chemical abstracts service number, registry of toxic effects of chemical substances number, production figures and economic trends, uses, and producer and user data are given for sodium-azide (26628228), lead-azide (13424469), and hydrazoic-acid (7782798). (cdc.gov)
  • For example, lead azide, used in detonators, may be prepared from the metathesis reaction between lead nitrate and sodium azide. (wikipedia.org)
  • It decomposes on heating to give nitrogen gas, which is used to quickly expand the air bag: 2 NaN3 → 2 Na + 3 N2 Heavy metal salts, such as lead azide, Pb(N3)2, are shock-sensitive detonators which decompose to the corresponding metal and nitrogen, for example: Pb(N3)2 → Pb + 3 N2 Silver and barium salts are used similarly. (wikipedia.org)
  • Sodium azide is a versatile precursor to other inorganic azide compounds, e.g., lead azide and silver azide, which are used in explosives. (wikipedia.org)
  • Something that I learned from this book that I did not know before was that there are 3 types of lead azide, with varying degrees of stability. (sciencemadness.org)
  • I have made the material but it has been 40 years ago and I observed the same low solubility that produces a colloidal precipitate similarly as for lead azide when strong solutions of precursors are reacted. (sciencemadness.org)
  • Effect of Adsorbate Reactions on Rates of Thermal Initiation of Lead Azide. (dtic.mil)
  • The time of thermal initiation to explosive decomposition of polycrystalline lead azide was studied as a function of interacting proton- and electron-donor vapors at the surface interface. (dtic.mil)
  • The adsorbate interactions are interpreted as inducing changes in the population of lead nuclei on the surface of lead azide. (dtic.mil)
  • These results are consistent with the concept that the thermal initiation of lead azide can be surface-catalyzed. (dtic.mil)
  • Some azides are produced by treating the carbonate salts with hydrazoic acid. (wikipedia.org)
  • Aliphatic alcohols give azides via a variant of the Mitsunobu reaction, with the use of hydrazoic acid. (wikipedia.org)
  • Protonation of azide salts gives toxic hydrazoic acid in the presence of strong acids: H+ + N− 3 → HN3 Azide salts may react with heavy metals or heavy metal compounds to give the corresponding azides, which are more shock sensitive than sodium azide alone. (wikipedia.org)
  • Azides of Antimony 'metallic Sb dissolves very slowly in hydrazoic acid, and owing to hydrolysis, no azide containing products can be isolated. (sciencemadness.org)
  • Lithium azide presents a challenge though without hydrazoic acid, and I'm not sure the synthesis of this is something I'm willing to do. (sciencemadness.org)
  • to direct hydroaminations of C-C double bonds with protected hydrazines or hydrazoic acid but are based on a different concept in which the H and the N atoms come from two different reagents, a silane and an oxidizing nitrogen source (azodicarboxylate or sulfonyl azide). (epfl.ch)
  • Home / Forums / Antibody Based Technologies: Assay Development & Protocols / Sodium Azide influence? (scientistsolutions.com)
  • I have a question: can NaN3 ( Sodium Azide) used as conservant for preservimg antibodies influence the reaction between antibody and antigen and what could be a mechanism of such an influence? (scientistsolutions.com)
  • I'm not aware of any direct effect of azide on the actual affinity of the antibody for the antigen. (scientistsolutions.com)
  • The amount of azide used to prevent bacterial growth is very unlikely to interfere with any downstream use of the antibody. (scientistsolutions.com)
  • This will let Azide pass through while retaining antibody and BSA in your sample. (protocol-online.org)
  • For these types of experiments, BioLegend has been providing 0.2 micron sterile-filtered, Low Endotoxin, Azide-Free (LEAF™) and Ultra-Low Endotoxin, Azide-Free (Ultra-LEAF™) antibody formulations, which eliminate unwanted effects from endotoxin and sodium azide. (biolegend.com)
  • Immunohistochemistry-Paraffin: EAAT2/GLT1 Antibody - Azide Free [NBP1-20136] - Mouse brain (hippocampus). (novusbio.com)
  • For lyophilized antibodies, we recommend reconstituting the antibody with glycerol and antimicrobial preservative like sodium azide for the longest shelf life (note that sodium azide is not compatible with HRP-conjugates). (biotium.com)
  • They react with amines to give the corresponding azides: RNH2 → RN3 A classic method for the synthesis of azides is the Dutt-Wormall reaction in which a diazonium salt reacts with a sulfonamide first to a diazoaminosulfinate and then on hydrolysis the azide and a sulfinic acid. (wikipedia.org)
  • Azides easily extrude diatomic nitrogen, a tendency that is exploited in many reactions such as the Staudinger ligation or the Curtius rearrangement or for example in the synthesis of γ-imino-β-enamino esters. (wikipedia.org)
  • In the laboratory, it is used in organic synthesis to introduce the azide functional group by displacement of halides. (wikipedia.org)
  • PEG azides are ideal starting materials for the synthesis of PEG derivatives via azide-alkyne cycloaddition or Staudinger ligation. (sigmaaldrich.com)
  • Steric Effects on the Regioselectivity of an Azide-Alkyne Dipolar Cycloaddition Reaction: The Synthesis of Human Leukocyte Elastase Inhibitors", J. Org. (freepatentsonline.com)
  • You may not have felt the need for a better synthesis of metal azides. (sciencemag.org)
  • For example, last year I wrote about mercury azides , a most alarming class of compounds whose synthesis would be much easier if the two solvent layers didn't keep getting disturbed by explosions. (sciencemag.org)
  • The book gives synthesis of all inorganic azides(metal and nommetal) and how to crystallize them, electronic structure, lattice dynamics, decomposition, etc..etc. (sciencemadness.org)
  • Some of copper azide complexes do sound interesting and I would like to try some of these if I can find a decent synthesis for them. (sciencemadness.org)
  • I am certain I have seen patents for rimfire primer compositions that deliberately used copper azide so it would seem that under precise conditions for synthesis it is possible to make a form of copper azide that has predictable properties. (sciencemadness.org)
  • New Methods for the Synthesis of Vinyl Azides. (docme.ru)
  • New Methods for the Synthesis of Vinyl Azides By Gerrit L'abbe and Alfred Hassner[*l A critical survey of synthetic approaches to vinyl azides is presented, focusing especially on stereo- and regiochemicalproblems. (docme.ru)
  • It is remarkable that vinyl azide (CH,=CHN,), the simplest of this class of unsaturated azides, was first described in 1910[11,yet most of the knowledge concerning the synthesis and reactions of these compounds has been gained during the past five years. (docme.ru)
  • Among the recently studied transformations of vinyl azides are their and phot~lysis[~] which serve as a general method of synthesis of azirines, a heretofore rare class of heterocycles. (docme.ru)
  • 98 Me \ N3 R-4 0 Me I c=c \ d_ R - CF-8C'0' The most recent synthetic application of vinyl azides is the synthesis of a reactive ketene in pure form[9]. (docme.ru)
  • More than 50 years ago, the first synthesis of tri-substituted triazoles was achieved by Huisgen via azide-alkyne cycloaddition. (springer.com)
  • In the manufacturing of pharmaceutical drug substances, azides are used in their synthesis or they are generated as an intermediate substance. (mdpi.com)
  • Sodium azide (NaN 3 ) is widely used as starting molecule in the synthesis of Sartans, a group of drugs that have been used for the treatment of hypertension since the 1990s [ 14 ]. (mdpi.com)
  • A one-pot protocol for the synthesis of triazole-annulated polyheterocycles via metal-catalyzed coupling of internal 1,4-disubstituted 1,3-diynes and organic azides has been described. (biomedsearch.com)
  • 1. A Cu(I) catalyzed process for preparing a 1,4-disubstituted 1,2,3-triazole comprising: contacting an organic azide and a terminal alkyne with a catalytic quantity of Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. (freepatentsonline.com)
  • Although some mechanistic evidence has been obtained, such as X-ray analysis of [protein]-["click ligand"] complexes, indicating that proteins act as both mold and template between unique pairs of azide and alkyne fragments, to date, observations have been based solely on "postclick" structural information. (rcsb.org)
  • Conjugates prepared with the thiol-reactive azide, succinimidyl ester can be detected with an alkyne-containing molecule in a click chemistry reaction. (thermofisher.com)
  • The two-step reaction procedure involves a copper-catalyzed triazole formation of an azide and an alkyne. (thermofisher.com)
  • The deprotected dendron with an acetylene focal group was coupled to the pendant azide groups of the modified linear copolypeptide, P(Glu-N 3 ), in a Cu(I) catalyzed azide-alkyne cycloaddition reaction to form a 1,4-disubstituted triazole. (mdpi.com)
  • IRDye 650 Azide provides the functionality for preferential labeling of molecules that contain either the alkyne or dibenzocyclooctyne (DBCO) group. (licor.com)
  • 1-Sulfonyl-1,2,3-triazoles, readily prepared by copper-catalyzed azide-alkyne cycloaddition, react with allenes in the presence of a nickel(0) catalyst to produce isopyrroles. (organic-chemistry.org)
  • Biotin picolyl azide reacts with alkyne to form 1,2,3-triazole by 1,3-dipolar Huisgen cycloaddition through the use of a much lower copper (I) concentration without sacrificing reaction efficiency. (biotium.com)
  • CF® dye azide reacts with alkyne to form 1,2,3-triazole by copper(I) catalyzed 1,3-dipolar Huisgen cycloaddition. (biotium.com)
  • Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based detection of global pathogen-host AMPylation on self-assembled human protein mi. (nih.gov)
  • Click-iT® Plus Alexa Fluor® picolyl azide toolkits contain everything you need to perform copper-catalyzed click reactions with compounds that are sensitive to copper, while retaining all of the benefits of the standard azide/alkyne click reaction. (thermofisher.com)
  • Guidelines for designing and optimizing the picolyl azide/alkyne click reaction of your choice are provided in the product manual. (thermofisher.com)
  • The experimental rate law for the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction was found to vary in complex ways with concentration, the presence of chloride ion, and the presence of accelerating ligands. (nih.gov)
  • Moderating strain without sacrificing reactivity: Design of fast and tunable non-catalyzed alkyne-azide cycloadditions via stereoelectronically controlled transition state stabilization. (biomedsearch.com)
  • Recently, we have identified two strategies for selective transition state (TS) stabilization in catalyst-free azide/alkyne cycloadditions. (biomedsearch.com)
  • An alternative route is direct reaction of the metal with silver azide dissolved in liquid ammonia. (wikipedia.org)
  • It turns out that silver azide in liquid ammonia slowly does redox reactions with a variety of other elements, giving a wide variety of otherwise hard-to-obtain compounds. (sciencemag.org)
  • The careful reader will have noted a defect in this scheme: you first have to make a supply of silver azide , which is enough of a show-stopper for me. (sciencemag.org)
  • As long as there is a residue of AgN3, the vessel only should be shaken very gently to prevent silver azide grains to be ground at the glass wall of the vessel. (sciencemag.org)
  • Crust formation occurring at the fluid level and consisting of silver azide at the beginning of the reaction and the respective metal azide at the end of the reaction have to be carefully scraped off the glass every day with a Teflon spatula. (sciencemag.org)
  • Zanirato, P. "Reactivity of Aryl and Heteroaryl Azides with Vinylsilane and Alkynylsilane. (freepatentsonline.com)
  • The reason for interest in this class of compounds is the high reactivity of the azide function which is susceptible to photolysis, pyrolysis, cycloadditions and attack by nucleophiles as well as by electrophilesl2I. (docme.ru)
  • The presence of a neighboring double bond accentuates the reactivity of the azide group and provides additional intramolecular pathways for reaction. (docme.ru)
  • In this case it is not possible to exclusively excite the ketone without directly exciting the azide moiety, thus only singlet reactivity of azide 1 is observed with acetone. (openthesis.org)
  • Thus, a bulky ƒÒƒ{substituent affects the reactivity of ƒÒƒ{azides. (openthesis.org)
  • Sodium azide inhibits cytochrome c oxidase (electron transport chain). (bio.net)
  • Sodium azide is made industrially by the reaction of nitrous oxide, N2O with sodium amide in liquid ammonia as solvent: N2O + 2 NaNH2 → NaN3 + NaOH + NH3 Many inorganic azides can be prepared directly or indirectly from sodium azide. (wikipedia.org)
  • The decomposition temperatures of the alkali metal azides are: NaN3 (275 °C), KN3 (355 °C), RbN3 (395 °C), and CsN3 (390 °C). This method is used to produce ultrapure alkali metals. (wikipedia.org)
  • 2 NaN3 + 2 HNO2 → 3 N2 + 2 NO + 2 NaOH Many inorganic covalent azides (e.g., chlorine, bromine, and iodine azides) have been described. (wikipedia.org)
  • Sodium azide is the inorganic compound with the formula NaN3. (wikipedia.org)
  • Organic azides engage in useful organic reactions. (wikipedia.org)
  • The azide ion (the three nitrogen molecule s) is remarkably unstable , and therefore reacts readily with water, acid, or metal to form the much more stable nitrogen gas (only two bond ed nitrogen molecules instead of three), providing the force for explosive reactions utilizing sodium azide. (everything2.com)
  • Compared to other inhibitors, sodium azide has been shown to interfere least with purely chemical Mn reactions (Rosson et al. (thefreedictionary.com)
  • That's because this isn't one of those set-it-and-forget-it Crock-Pot azide reactions. (sciencemag.org)
  • Picolyl azides react efficiently with chelated copper, so free copper in the click reaction can be minimized, protecting against undesired copper side reactions with proteins (e.g. (thermofisher.com)
  • Azide salts can decompose with release of nitrogen gas. (wikipedia.org)
  • Another azide regular is tosyl azide here in reaction with norbornadiene in a nitrogen insertion reaction: About 250 tons of azide-containing compounds are produced annually, the main product being sodium azide. (wikipedia.org)
  • Each azide is linked to six Na+ centers, with three Na-N bonds to each terminal nitrogen center. (wikipedia.org)
  • An electrical charge triggered by automobile impact causes sodium azide to explode and convert to nitrogen gas inside the airbag. (cdc.gov)
  • 3] reacted with the nitrogen to form ammonium azide (~1/3 of the product), which precluded further nitridation even if ammonium azide is one of the nitrogen agents. (thefreedictionary.com)
  • A few reasons sodium azide may have been selected for use in airbags are it releases gas fast, the gas it releases is pure nitrogen (of course, when sodium azide is mixed with other explosive or pyrotechnic ingredients, the resulting gas composition is altered), and it's fairly stable when it's inside an airbag system under most environmental conditions automobiles encounter. (thefreedictionary.com)
  • To explore new stable polymeric nitrogen phases in alkali metal azides, the crystalline structures of potassium azide KN 3 , are systematically investigated up to 400 GPa by using unbiased structure searching methods combined with first principles density functional calculations. (rsc.org)
  • We considered 14 N NMR spectroscopy as one of the most suitable methods for the characterization of azides to show resonance signals corresponding to the three non-equivalent nitrogen atoms. (mdpi.com)
  • Key to the development of the hydroazidation reaction was the use of sulfonyl azides as nitrogen sources and the activating effect of tert-Bu hydroperoxide. (epfl.ch)
  • Once generated, the ketone can transfer its triplet energy to the azide moiety which loses molecular nitrogen to give a triplet alkyl nitrene intermediate. (openthesis.org)
  • Azide is the anion with the formula N− 3. (wikipedia.org)
  • The azide anion is very similar in each form, being centrosymmetric with N-N distances of 1.18 Å. (wikipedia.org)
  • Equally explosive is the yellow anion[SbCl5(N3)]- which is obtained as the crystalline potassium salt from SbCl5 and potassium azide in liquid SO2. (sciencemadness.org)
  • 7-hecombined procedure of azidohdogenationof olefins followed by dehydrohalogenation, leads to regiospecificand, in the case of ionic additions, also to stereospecificformation of vinyl azides. (docme.ru)
  • Pyrolysis of some vinyl azides has furnished indole [email protected] 51. (docme.ru)
  • The compound is obtained by azidation of antimony pentachloride with chlorine azide or with trimethylsilyl azide. (sciencemadness.org)
  • The azo-transfer compounds, trifluoromethanesulfonyl azide and imidazole-1-sulfonyl azide, are prepared from sodium azide as well. (wikipedia.org)
  • Surface modifiers currently offered include titanates, sulfonyl azide , ester-based wetting agents, and proprietary coatings. (thefreedictionary.com)
  • Various functionalized aryl azides and aryl sulfonyl azides are reduced to the corresponding amines with excellent chemoselectivity in high yields. (organic-chemistry.org)
  • Merkx, R. , Rijkers, D. T. S. , Brouwer, A. J. , Kemmink, J. and Liskamp, R. M. J. (2006) Peptide-derived (sulfonyl)Azides as versatile synthons in chemoselective bioconjugations. (gla.ac.uk)
  • The seriousness of poisoning caused by sodium azide depends on the amount, route, and length of time of exposure, as well as the age and preexisting medical condition of the person exposed. (cdc.gov)
  • Death from exposure to a large amount of sodium azide will usually occur within thirty minutes, a toxicity on par with sodium cyanide . (everything2.com)
  • Signs and symptoms of sodium azide poisoning include lethargy or coma (possibly sudden collapse), dyspnea, tachypnea, tachycardia, and hypotension. (cdc.gov)
  • Curtius and Thiele developed another production process, where a nitrite ester is converted to sodium azide using hydrazine. (wikipedia.org)
  • an important one being N − = N + = N − {\displaystyle {\ce {^{-}N={\overset {+}{N}}=N^{-}}}} . Azide is also a functional group in organic chemistry, RN3. (wikipedia.org)
  • Some organic azides are potential rocket propellants, an example being 2-dimethylaminoethylazide (DMAZ). (wikipedia.org)
  • Due to its explosion hazard, sodium azide is of only limited value in industrial-scale organic chemistry. (wikipedia.org)
  • 1. Introduction During the last few years unsaturated azides have acquired considerable importance as intermediates in organic syntheses and new methods for their preparation have been devised. (docme.ru)
  • The reaction of O-methyl thiocarboxylates 8a, b with organic azides at 110°C yielded the corresponding imidates of type 9, which were easily hydrolyzed to give amides 10. (uzh.ch)
  • Hydrazines may also form azides by reaction with sodium nitrite: PhNHNH2 + NaNO2 → PhN3 Alkyl or aryl acyl chlorides react with sodium azide in aqueous solution to give acyl azides, which give isocyanates in the Curtius rearrangement. (wikipedia.org)
  • The alkyl azides obtained are versatile intermediates and can be transformed to the free amines or triazoles without isolation of the azides. (epfl.ch)
  • A metal catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to give triazoles. (freepatentsonline.com)
  • Water soluble yellow emitting fluorescent dye azide for click chemistry. (abcam.com)
  • the azido functions carried by glycidyl azide which are successfully incorporated into the backbones of polyethers and polycarbonates based on cyclohexene oxide and propylene oxide subsequently served to introduce other functions by click chemistry. (nature.com)
  • IRDye 650 Azide Infrared Dye for Click Chemistry. (licor.com)
  • Each Click-iT® Plus Picolyl Azide Toolkit includes 100 µg of Alexa Fluor® dye-picolyl azide and all of the reagents required to create a reaction cocktail with the optimal copper and chelate concentration for any click chemistry-based labeling or detection application. (thermofisher.com)
  • That is why we are transitioning our LEAF™ (Low Endotoxin, Azide-Free) purified antibodies to Ultra-LEAF™ formulation. (biolegend.com)
  • This market research report examines the foreign trade of Switzerland and its perspectives on the global market for hydrides, nitrides, azides, silicides and borides. (marketpublishers.com)
  • The report will be of considerable interest primarily to relevant strategic planners, senior company officials and importers/exporters, since it features invaluable information on hydrides, nitrides, azides, silicides and borides export/import operations in Switzerland. (marketpublishers.com)
  • The report studies how Switzerland behaves on the global market for hydrides, nitrides, azides, silicides and borides. (marketpublishers.com)
  • It also assesses the dynamics of country's foreign trade in hydrides, nitrides, azides, silicides and borides in 2006-2016. (marketpublishers.com)
  • The report indicates major suppliers and consumers of hydrides, nitrides, azides, silicides and borides in Switzerland. (marketpublishers.com)
  • The final chapter provides in-depth analysis of prospects for the country's foreign trade in hydrides, nitrides, azides, silicides and borides, as well the forecast for the development of the market for hydrides, nitrides, azides, silicides and borides up to 2021. (marketpublishers.com)
  • This report examines international trade and worldwide market trends pertaining to hydrides, nitrides, azides, silicides and borides. (marketpublishers.com)
  • The report provides the following analytical materials on the hydrides, nitrides, azides, silicides and borides: general description, international trade dynamics (2011-2016), exports/imports (2016) broken down by country, major suppliers and consumers, average price. (marketpublishers.com)
  • 1. The effects of the metabolic inhibitor sodium azide were tested on excised macropatches from Xenopus oocytes expressing cloned ATP-sensitive potassium (KATP) channels of the Kir6.2/SUR1 type. (nih.gov)
  • Sodium azide solutions react with metallic ions to precipitate metal azides, which can be shock sensitive and explosive. (wikipedia.org)
  • Enzymes inhibited by azide respond differently upon addition of fluoride or chloride ions to the sample solution inhibited by azide. (springer.com)
  • Fluoride ions compete with azide for binding at one of the T2/T3 Cu ions, whereas competition from chloride ions is much less evident. (springer.com)
  • Nucleophilicsubstitutions by azide ions on activated olefinichalides result in p-azidovinyl ketones, esters,nitriles, etc., and proceed predominantly with retention of configurationabout the C=C bond. (docme.ru)
  • CF dye with BCN, an alternative to fluorescently labeled DIBO and DBCO, reacts with azide to form 1,2,3-triazole by copper free 1,3-dipolar Huisgen cycloaddition. (biotium.com)
  • Sodium azide (NaN 3 ) is an odorless white solid that react s violently with water , acid , or solid metal ( lead or copper , for instance). (everything2.com)
  • The principal source of the azide moiety is sodium azide. (wikipedia.org)
  • Intermolecular sensitized photolysis of benzyl azide led to N-methyleneaniline as the major photoproduct with acetophenone as the triplet sensitizer. (openthesis.org)
  • When the hyperconjugative assistance is maximized by the antiperiplanar arrangement of propargylic σ-acceptors relative to the forming bonds, the combination of these TS-stabilizing effects was predicted to lead to ~1 million fold acceleration of the cycloaddition with methyl azide. (biomedsearch.com)
  • So if anyone wants info on any inorganic azide, I'll gladly retype the info that is wanted. (sciencemadness.org)
  • Appropriately functionalized aliphatic compounds undergo nucleophilic substitution with sodium azide. (wikipedia.org)
  • It is used for the preparation of other azide compounds. (wikipedia.org)
  • Some organoantimony azides are known, such as the liquid (C6H5)2SbN3, which resembles the respective P and S compounds. (sciencemadness.org)
  • Reacts with both copper and lead to produce explosive azides. (hazard.com)
  • There's also a lithium/copper azide complex I have read about that sounds interesting too. (sciencemadness.org)
  • It does have a pretty bad rep but I I found the copper II azide to be less sensitive as I first thought.it really is made out to be a monster. (sciencemadness.org)
  • The copper I azide seemed far more sensitive,easily detonating violently even with light taps of the hammer. (sciencemadness.org)
  • I know the tetraamine copper azide can be made by running a stream of dry ammonia gas over the Cu 2 azide or by dissolving it in ammonia and then evaporation of the liquid with the blue precipitate being the product. (sciencemadness.org)
  • I do know that it does quickly lose the ammonia though and reverts back to copper azide. (sciencemadness.org)
  • Aryl azides undergo clean reduction by copper nanoparticles in water in the presence of ammonium formate. (organic-chemistry.org)
  • An infrared spectroelectrochemical study of Trametes hirsuta laccase and Magnaporthe oryzae bilirubin oxidase has been performed using azide, an inhibitor of multicopper oxidases, as an active infrared probe incorporated into the T2/T3 copper cluster of the enzymes. (springer.com)
  • So I thought today I'd step back to a period when men were men and chlorine azide was a reactive, toxic, and unstable compound that was only good for finding out what sort of explosion it would set off next. (sciencemag.org)
  • Yellow dye (Reactive group: azide). (tocris.com)
  • The slight red shift in absorption spectrum makes Fluorescent Dye 647-I Azide an optimal match to filters designed Cy5 dyes.Besides, their fluorescence is pH-independent from pH 3 to 11. (abnova.com)
  • In many instances, the reaction sequence regiospecifically ligates azides and terminal acetylenes to give only 1,4-disubstituted [1,2,3]-triazoles. (freepatentsonline.com)
  • Recent tri-substituted triazoles development based on various azides and double bonds have been summarized in this report. (springer.com)
  • A reader forwarded this 1943 JACS article , the first comprehensive study of chlorine azide, and it's a joy to read. (sciencemag.org)
  • If small pieces of yellow phosphorus be added, with stirring, to a solution of chlorine azide in carbon tetrachloride at 0C, the solution gradually becomes turbid, and a succession of slight explosions takes place beneath the liquid. (sciencemag.org)
  • What else doth chlorine azide detonate with? (sciencemag.org)
  • But chlorine azide has not been weaponized, nor will it be. (sciencemag.org)
  • In addition to all of this, sodium azide is also incredibly toxic , reacting to form a gas that is lighter than air and prevents the body from using oxygen properly. (everything2.com)
  • When it is mixed with water or an acid, sodium azide changes rapidly to a toxic gas with a pungent (sharp) odor. (cdc.gov)
  • In one case, sodium azide was poured into a drain, where it exploded and the toxic gas was inhaled (breathed in). (cdc.gov)
  • An explosion involving sodium azide may cause burn injury as well as expose people to the toxic gas, hydrozoic acid. (cdc.gov)
  • Breathing the gas that is formed from sodium azide causes the most harm, but ingesting (swallowing) sodium azide can be toxic as well. (cdc.gov)
  • PACE cited documents reporting a high volume of materials containing highly toxic sodium azide going from Breed Tech. (thefreedictionary.com)
  • Azide free phosphate buffered saline (PBS), approx. (genetex.com)
  • The generality of the method has been demonstrated by using a series of aromatic/aliphatic azides and symmetrical internal 1,3-diynes. (biomedsearch.com)
  • Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation", Proc. (freepatentsonline.com)
  • Shown is a corundum crucible before and after heating up a sample of the manganese azide product (as an ammonia complex). (sciencemag.org)
  • The risks presented by even small amounts of sodium azide are great, and yet its use is maintained in automobiles, hospitals, and agriculture . (everything2.com)
  • For example equimolar amounts of ammonium chloride and sodium azide may be distilled with an equal quantity of water. (sciencemadness.org)
  • I made Hg azide in tiny amounts in plastic vessels. (sciencemadness.org)
  • Despite the widespread opinion of proponents of sodium azide use in water and soil, who argue that this chemical undergoes rapid hydrolysis and degradation [ 11 , 12 ], their opponents [ 13 ] claim that this is not exactly what can be anticipated, since they have discovered water and soil samples containing residual amounts of sodium azide. (mdpi.com)
  • Azides may be reduced to amines by hydrogenolysis or with a phosphine (e.g., triphenylphosphine) in the Staudinger reaction. (wikipedia.org)
  • The azide functional group can thereafter be converted to an amine by reduction with either SnCl2 in ethanol or lithium aluminium hydride or a tertiary phosphine, such as triphenylphosphine in the Staudinger reaction, with Raney nickel or with hydrogen sulfide in pyridine. (wikipedia.org)
  • Energetic binders that appear to offer such promising characteristics include azide functional polymers like glycidyl azide polymer (GAP), poly(3, 3-bisazidomethyloxe-tane) (PBAMO), and poly-(3-azidomethyl-3-methyloxetane) (PAMMO), nitrato polyethers like poly-((3-nitrato methyl)-3-methyl oxetane) (PNIMMO), poly-(glycidyl nitrate) (PGLYN)), poly(vinyl nitrate)s, fluoro-polymers, etc. (thefreedictionary.com)
  • Glycidyl azide polymer or poly(glycidyl azide) which is considered as an excellent energetic binder or plasticizer in advanced solid propellants is generally obtained by post-modification or azidation of poly(epichlorohydrin). (nature.com)
  • Here we report that glycidyl azide can be directly homopolymerized through anionic ring-opening polymerization to access poly(glycidyl azide) using onium salts as initiator and triethyl borane as activator. (nature.com)
  • Molar masses of poly(glycidyl azide) up to 11.0 Kg/mol are achieved in a controlled manner with a narrow polydispersity index (PDI ≤ 1.2). (nature.com)
  • Similarly, alternating poly(glycidyl azide carbonate) are also prepared through alternating copolymerization of glycidyl azide with carbon dioxide. (nature.com)
  • No literature reference could be found indicating how to polymerize glycidyl azide (GA) to obtain the corresponding polymer, PGA. (nature.com)
  • yielded a mixture of sodium chloride and sodium azide. (sciencemag.org)
  • A case in which sodium azide in serum is detected, as determined by a commercial laboratory. (cdc.gov)
  • A clinically compatible case in which a high index of suspicion (credible threat or patient history regarding location and time) exists for sodium azide exposure, or an epidemiologic link exists between this case and a laboratory-confirmed case. (cdc.gov)
  • We are having some arguments about the concentration of sodium azide to use in sandwich box reservoirs containing PEG or in drops containing PEG. (bio.net)
  • The inhibitory effect of Na-azide was mimicked by the same concentration of NaCl, but not by sucrose. (nih.gov)
  • The direct effects of 3 mM Na-azide on KATP channels are negligible in comparison to the metabolic activation produced by the same Na-azide concentration. (nih.gov)
  • Persons who work on automobiles regularly are at an increased risk of exposure to sodium azide, which is used as a propellant in airbags. (cdc.gov)
  • Exposure to sodium azide can be fatal. (cdc.gov)
  • Ingestion is an important route of exposure to solid sodium azide. (cdc.gov)
  • Moving to an area with fresh air is a good way to reduce the possibility of death from exposure to sodium azide. (cdc.gov)
  • Sodium azide is an example of an azide for which the environmental exposure limits have been reasonably well characterized. (mdpi.com)
  • Sodium azide is a useful probe reagent and a preservative. (wikipedia.org)
  • Sodium azide is used as a chemical preservative in hospitals and laboratories. (cdc.gov)