Organic or inorganic compounds that contain the -N3 group.
A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Organic compounds that contain two nitro groups attached to a phenol.
An enzyme that converts ascorbic acid to dehydroascorbic acid. EC 1.10.3.3.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The rate dynamics in chemical or physical systems.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.

Cross-linking of two beta subunits in the closed conformation in F1-ATPase. (1/2265)

In the crystal structure of mitochondrial F1-ATPase, two beta subunits with a bound Mg-nucleotide are in "closed" conformations, whereas the third beta subunit without bound nucleotide is in an "open" conformation. In this "CCO" (beta-closed beta-closed beta-open) conformational state, Ile-390s of the two closed beta subunits, even though they are separated by an intervening alpha subunit, have a direct contact. We replaced the equivalent Ile of the alpha3beta3gamma subcomplex of thermophilic F1-ATPase with Cys and observed the formation of the beta-beta cross-link through a disulfide bond. The analysis of conditions required for the cross-link formation indicates that: (i) F1-ATPase takes the CCO conformation when two catalytic sites are filled with Mg-nucleotide, (ii) intermediate(s) with the CCO conformation are generated during catalytic cycle, (iii) the Mg-ADP inhibited form is in the CCO conformation, and (iv) F1-ATPase dwells in conformational state(s) other than CCO when only one (or none) of catalytic sites is filled by Mg-nucleotide or when catalytic sites are filled by Mg2+-free nucleotide. The alpha3beta3gamma subcomplex containing the beta-beta cross-link retained the activity of uni-site catalysis but lost that of multiple catalytic turnover, suggesting that open-closed transition of beta subunits is required for the rotation of gamma subunit but not for hydrolysis of a single ATP.  (+info)

Activation of Go-proteins by membrane depolarization traced by in situ photoaffinity labeling of galphao-proteins with [alpha32P]GTP-azidoanilide. (2/2265)

Evidence for depolarization-induced activation of G-proteins in membranes of rat brain synaptoneurosomes has been previously reported (Cohen-Armon, M., and Sokolovsky, M. (1991) J. Biol. Chem. 266, 2595-2605; Cohen-Armon, M., and Sokolovsky, M. (1993) J. Biol. Chem. 268, 9824-9838). In the present work we identify the activated G-proteins as Go-proteins by tracing their depolarization-induced in situ photoaffinity labeling with [alpha32P]GTP-azidoanilide (GTPAA). Labeled GTPAA was introduced into transiently permeabilized rat brain-stem synaptoneurosomes. The resealed synaptoneurosomes, while being UV-irradiated, were depolarized. Relative to synaptoneurosomes at resting potential, the covalent binding of [alpha32P]GTPAA to Galphao1- and Galphao3-proteins, but not to Galphao2- isoforms, was enhanced by 5- to 7-fold in depolarized synaptoneurosomes, thereby implying an accelerated exchange of GDP for [alpha32P]GTPAA. Their depolarization-induced photoaffinity labeling was independent of stimulation of Go-protein-coupled receptors and could be reversed by membrane repolarization, thus excluding induction by transmitters release. It was, however, dependent on depolarization-induced activation of the voltage-gated sodium channels (VGSC), regardless of Na+ current. The alpha subunit of VGSC was cross-linked and co-immunoprecipitated with Galphao-proteins in depolarized brain-stem and cortical synaptoneurosomes. VGSC alpha subunit most efficiently cross-linked with guanosine 5'-O-2-thiodiphosphate-bound rather than to guanosine 5'-O-(3-thiotriphosphate)-bound Galphao-proteins in isolated synaptoneurosomal membranes. These findings support a possible involvement of VGSC in depolarization-induced activation of Go-proteins.  (+info)

Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity. (3/2265)

G protein-coupled receptors are commonly thought to bind their cognate ligands and elicit functional responses primarily as monomeric receptors. In studying the recombinant gamma-aminobutyric acid, type B (GABAB) receptor (gb1a) and a GABAB-like orphan receptor (gb2), we observed that both receptors are functionally inactive when expressed individually in multiple heterologous systems. Characterization of the tissue distribution of each of the receptors by in situ hybridization histochemistry in rat brain revealed co-localization of gb1 and gb2 transcripts in many brain regions, suggesting the hypothesis that gb1 and gb2 may interact in vivo. In three established functional systems (inwardly rectifying K+ channel currents in Xenopus oocytes, melanophore pigment aggregation, and direct cAMP measurements in HEK-293 cells), GABA mediated a functional response in cells coexpressing gb1a and gb2 but not in cells expressing either receptor individually. This GABA activity could be blocked with the GABAB receptor antagonist CGP71872. In COS-7 cells coexpressing gb1a and gb2 receptors, co-immunoprecipitation of gb1a and gb2 receptors was demonstrated, indicating that gb1a and gb2 act as subunits in the formation of a functional GABAB receptor.  (+info)

Resolution of the paradox of red cell shape changes in low and high pH. (4/2265)

The molecular basis of cell shape regulation in acidic pH was investigated in human erythrocytes. Intact erythrocytes maintain normal shape in the cell pH range 6.3-7.9, but invaginate at lower pH values. However, consistent with predicted pH-dependent changes in the erythrocyte membrane skeleton, isolated erythrocyte membranes evaginate in acidic pH. Moreover, intact cells evaginate at pH greater than 7.9, but isolated membranes invaginate in this condition. Labeling with the hydrophobic, photoactivatable probe 5-[125I]iodonaphthyl-1-azide demonstrated pH-dependent hydrophobic insertion of an amphitropic protein into membranes of intact cells but not into isolated membranes. Based on molecular weight and on reconstitution experiments using stripped inside-out vesicles, the most likely candidate for the variably labeled protein is glyceraldehyde-3-phosphate dehydrogenase. Resealing of isolated membranes reconstituted both the shape changes and the hydrophobic labeling profile seen in intact cells. This observation appears to resolve the paradox of the contradictory pH dependence of shape changes of intact cells and isolated membranes. In intact erythrocytes, the demonstrated protein-membrane interaction would oppose pH-dependent shape effects of the spectrin membrane skeleton, stabilizing cell shape in moderately abnormal pH. Stabilization of erythrocyte shape in moderately acidic pH may prevent inappropriate red cell destruction in the spleen.  (+info)

Analysis of the membrane-interacting domains of myelin basic protein by hydrophobic photolabeling. (5/2265)

Myelin basic protein is a water soluble membrane protein which interacts with acidic lipids through some type of hydrophobic interaction in addition to electrostatic interactions. Here we show that it can be labeled from within the lipid bilayer when bound to acidic lipids with the hydrophobic photolabel 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine (TID) and by two lipid photolabels. The latter included one with the reactive group near the apolar/polar interface and one with the reactive group linked to an acyl chain to position it deeper in the bilayer. The regions of the protein which interact hydrophobically with lipid to the greatest extent were determined by cleaving the TID-labeled myelin basic protein (MBP) with cathepsin D into peptides 1-43, 44-89, and 90-170. All three peptides from lipid-bound protein were labeled much more than peptides from the protein labeled in solution. However, the peptide labeling pattern was similar for both environments. The two peptides in the N-terminal half were labeled similarly and about twice as much as the C-terminal peptide indicating that the N-terminal half interacts hydrophobically with lipid more than the C-terminal half. MBP can be modified post-translationally in vivo, including by deamidation, which may alter its interactions with lipid. However, deamidation had no effect on the TID labeling of MBP or on the labeling pattern of the cathepsin D peptides. The site of deamidation has been reported to be in the C-terminal half, and its lack of effect on hydrophobic interactions of MBP with lipid are consistent with the conclusion that the N-terminal half interacts hydrophobically more than the C-terminal half. Since other studies of the interaction of isolated N-terminal and C-terminal peptides with lipid also indicate that the N-terminal half interacts hydrophobically with lipid more than the C-terminal half, these results from photolabeling of the intact protein suggest that the N-terminal half of the intact protein interacts with lipid in a similar way as the isolated peptide. The similar behavior of the intact protein to that of its isolated peptides suggests that when the purified protein binds to acidic lipids, it is in a conformation which allows both halves of the protein to interact independently with the lipid bilayer. That is, it does not form a hydrophobic domain made up from different parts of the protein.  (+info)

Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918. (6/2265)

The acridone carboxamide derivative GG918 (N-{4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-pheny l}-9,10dihydro-5-methoxy-9-oxo-4-acridine carboxamide) is a potent inhibitor of MDR1 P-glycoprotein-mediated multidrug resistance. Direct measurements of ATP-dependent MDR1 P-glycoprotein-mediated transport in plasma membrane vesicles from human and rat hepatocyte canalicular membranes indicated 50% inhibition at GG918 concentrations between 8 nM and 80 nM using N-pentyl-[3H]quinidinium, ['4C]doxorubicin and [3H]daunorubicin as substrates. The inhibition constant K for GG918 was 35 nM in rat hepatocyte canalicular membrane vesicles with [3H]daunorubicin as the substrate. Photoaffinity labelling of canalicular and recombinant rat Mdr1b P-glycoprotein by [3H]azidopine was suppressed by 10 muM and 40 muM GG918. The high selectivity of GG918-induced inhibition was demonstrated in canalicular membrane vesicles and by analysis of the hepatobiliary elimination in rats using [3H]daunorubicin, [3H]taurocholate and [3H]cysteinyl leukotrienes as substrates for three distinct ATP-dependent export pumps. Almost complete inhibition of [3H]daunorubicin transport was observed at GG918 concentrations that did not affect the other hepatocyte canalicular export pumps. The high potency and selectivity of GG918 for the inhibition of human MDR1 and rat Mdr1b P-glycoprotein may serve to interfere with this type of multidrug resistance and provides a tool for studies on the function of these ATP-dependent transport proteins.  (+info)

Influence of bioenergetic stress on heat shock protein gene expression in nucleated red blood cells of fish. (7/2265)

The physiological and biochemical signals that induce stress protein (HSP) synthesis remain conjectural. In this study, we used the nucleated red blood cells from rainbow trout, Oncorhynchus mykiss, to address the interaction between energy status and HSP gene expression. Heat shock (25 degrees C) did not significantly affect ATP levels but resulted in an increase in HSP70 mRNA. Hypoxia alone did not induce HSP transcription in these cells despite a significant depression in ATP. Inhibition of oxidative phosphorylation with azide, in the absence of thermal stress, decreased ATP by 56% and increased lactate production by 62% but did not induce HSP gene transcription. Inhibition of oxidative phosphorylation and glycolysis with azide and iodoacetic acid respectively, decreased ATP by 79% and prevented lactate production, but did not induce either HSP70 or HSP30 gene transcription in these cells. This study demonstrates that a reduction in the cellular energy status will not induce stress protein gene transcription in rainbow trout red blood cells and may, in fact, limit induction during extreme metabolic inhibition.  (+info)

Influence of different types of effectors on the kinetic parameters of suicide inactivation of catalase by hydrogen peroxide. (8/2265)

The effects of cyanide and azide ions (class A), sodium-n-dodecyl sulphate (SDS) and 2-mercaptoethanol (class B), 3-aminotriazole (class C) and NADPH (class D) on the initial activity (ai), inactivation rate constant (ki) and the partition ratio (r) of bovine liver catalase reaction with its suicide substrate, hydrogen peroxide, were studied in 50 mM sodium phosphate buffer, pH 7.0 at 27 degrees C. The above kinetic parameters were determined by processing the progress curve data. In class A, which contains fast and reversible inhibitors of catalase, a proportional decrease in ai and ki was observed by inhibitors, so that the r remained constant. In class B, which contains slow and irreversible inactivators, a decrease in ai and constancy of ki and r were observed when catalase was incubated in the presence of such inactivators for a determined time. In class C, containing effector which can combine with intermediate compound I, ai was relatively unchanged but an increase in ki and a decrease in r were observed. In class D, containing effector which reduces compound I to ferricatalase, ai was not affected significantly but some decrease in ki was detected which was linked with an increase in r. These results demonstrate that different classes of effectors affect the determined kinetic parameters of catalase in various ways. Thus, determination of such parameters by simple kinetic experiments can be carried out for classification of the agents which have an effect on the kinetics of catalase.  (+info)

New redox labelling of DNA by an azido group which can be chemically transformed to nitrophenyltriazole or silenced to phenyltriazole was developed and applied to the electrochemical detection of DNA-protein interactions. 5-(4-Azidophenyl)-2-deoxycytidine and 7-(4-azidophenyl)-7-deaza-2-deoxyadenosine nucleosides were prepared by aqueous-phase Suzuki cross-coupling and converted to nucleoside triphosphates (dNTPs) which served as substrates for incorporation into DNA by DNA polymerase. The azidophenyl-modified nucleotides and azidophenyl-modified DNA gave a strong signal in voltammetric studies, at -0.9 V, due to reduction of the azido function. The Cu-catalyzed click reaction of azidophenyl-modified nucleosides or azidophenyl-modified DNA with 4-nitrophenylacetylene gave nitrophenyl-substituted triazoles, exerting a reduction peak at -0.4 V under voltammetry, whereas the click reaction with phenylacetylene gave electrochemically silent phenyltriazoles. The transformation of the azidophenyl ...
Originally reported by Staudinger and Meyer, azides react readily with triarylphosphines to form the corresponding iminophophoranes. The Staudinger Ligation: A High-Yield, Chemoselective, and Mild Synthetic Method.
Smolinsky, G. and Pryde, G. A. (1971) The chemistry of vinyl azides, in The Azido Group (1971) (ed S. Patai), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470771266.ch10 ...
Define azide. azide synonyms, azide pronunciation, azide translation, English dictionary definition of azide. n. Chemistry The univalent linear group N3, or any compound that contains this group, many of which are explosive. az′i·do′ adj. n 1. any compound...
Cy7 Picolyl Azide is an advanced fluorescent probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site. The chelating effect of picolyl azide moiety to raise the effective concentration of copper at the reaction site is so great that it leads to an increase of signal intensity of up to 40-fold. In addition, the use of Cy7 Picolyl Azide instead of conventional Cy7-Azide allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labelling. In summary, the introduction of a picolyl moiety into an azide probe leads to a substantial increase in the sensitivity of alkyne detection. This will be of special value for the detection of low abundance targets or where significant increase in signal intensity is desired.
76444-18-3 - HZEKZNNVGVLXHW-UYYQOESLSA-N - beta-(4-Azidophenyl)adenylyl-(3-5)-uridine 5-diphosphate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
The abstract is the summary of three different projects all centered around the generalidea of catalysis which is the general theme of research in the Michaelis laboratory. The firstproject focuses on development of a new heterogeneous catalyst for selective catalysis. In theMichaelis lab, we were interested in the potential of nanoparticle catalysts for regioselectivetransformations. We showed that polymer supported ruthenium nanoparticles performed as areliable catalyst for regioselective reduction of azide to amine. In our study of regioselectivereduction of multiple azide containing substrates, we observed that in presence of ourruthenium nanoparticle catalysts, the least sterically hindered azide group reduced to aminefunctional group. The results were complementary to the conventional methods that employtriphenyl phosphine (Staudinger reaction) as the reductant and target the most electronicallyactive azide group.In the second project, we were looking to develop a new class of hetero
It is well-known that azide salts can engage nitriles at elevated temperatures to yield tetrazoles; however, there is continued debate as to the mechanism of the reaction. Density functional theory calculations with the hybrid functional B3LYP have been performed to study different mechanisms of tetrazole formation, including concerted cycloaddition and stepwise addition of neutral or anionic azide species. The calculations presented here suggest a previously unsuspected nitrile activation step en route to an imidoyl azide, which then cyclizes to give the tetrazole. The activation barriers are found to correlate strongly with the electron-withdrawing potential of the substituent on the nitrile ...
The PEG Azide can potentially be reacted with an acetylene moiety (Click reaction) or an arylphosphinederivative, as part of several Staudinger ligation options (see references). It can also be used as a precursor to the amine function in which it can be transformed via reduction with P(Ph)3 ...
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A two-stage microreactor continuous flow system allows the handling organic azides safely in small hold-up volumes with immediate conversion in the 2nd microreactor. In the 1st microreactor the azide intermediate is formed by nucleophilic substitution.1 The azide intermediate is submitted to Staudinger hydration with triphenylphosphine in a subsequent 2nd microreactor. Notably, it is possible to work with biphasic systems in microreactors. A phase transfer catalyst moderates the initial reaction with efficient mixing by the microreactor. Production capacity of o-Xylylenediamine (711462) in two subsequent glass microreactors exceeds 1 kg per day with an overall yield of 60%. Work-up and isolation of the potentially hazardous intermediate is completely avoided between reaction steps, saving time, money and offering scale-independent safety levels. back to top ...
How to remove azide from antibody - posted in Immunology: Does anybody know how to remove sodium azide from the comercial antiboy solutions? I know there are two ways: dialyzing or exchanging over a column. Could anyone provide more detailed information? Thank you all!
3-Isoxazolecarbonyl azide,5-(fluoromethyl)-/ACM625120083 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Rabbit recombinant monoclonal Histone H2B (yeast) antibody [EPR18094] - BSA and Azide free. Validated in WB, ChIP, PepArr and tested in Saccharomyces cerevisiae, Recombinant fragment.
Gentaur molecular products has all kinds of products like :search , Accu \ Mouse TCR gamma_delta, Clone GL_3, Hamster Mab anti_, azide_free \ ACL7201NA for more molecular products just contact us
Rabbit recombinant monoclonal Histone H4 (mono methyl R92) antibody [EPR21782] - BSA and Azide free. Validated in WB, IHC, Flow Cyt, Dot, ICC/IF and tested in Mouse, Rat, Human.
2-Butenoyl azide, 4-(4-morpholinyl)-4-oxo-3-phenyl- | C14H14N4O3 | CID 71392707 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Anti-Human IL-8 Azide Free: Suitable for Flow Cytometry intra-cytoplamic. Blocks IL-8 induced chemotaxis of human neutrophils
Rabbit Polyclonal Anti-LC3A Antibody - Azide Free. Autophagosome Marker. Validated: WB, IHC-P. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
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Boc-N-Amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. - Mechanism of Action & Protocol.
Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental restoratives Journal Article ...
TY - JOUR. T1 - The traceless Staudinger ligation for indirect 18F- radiolabelling. AU - Carroll, Laurence. AU - Boldon, Sophie. AU - Bejot, Romain. AU - Moore, Jane E.. AU - Declerck, Jérôme. AU - Gouverneur, Véronique. PY - 2011/1/1. Y1 - 2011/1/1. N2 - The Staudinger ligation of phosphine-substituted thioesters with 18F-fluoroethylazide has been successfully applied to access 18F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.. AB - The Staudinger ligation of phosphine-substituted thioesters with 18F-fluoroethylazide has been successfully applied to access 18F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligation has been validated.. UR - http://www.scopus.com/inward/record.url?scp=78650098745&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=78650098745&partnerID=8YFLogxK. U2 - 10.1039/c0ob00564a. DO - ...
Establishment of appropriate cell labeling and tracking method is essential for the development of cell-based therapeutic strategies. Here, we are introducing a new method for cell labeling and tracking by combining etabolic glycoengineering and bioorthogonal chemistry. First, cells were treated with unnatural sugars as Ac4ManNAz, Ac4GalNAz, Ac4GlcNAz to generate unnatural azide groups (-N3) on the surface of the cells. Subsequently, the unnatural azide groups on the cell surface were specifically conjugated with cyclooctyne modified dye or nanoparticles through bioorthogonal copper-free click chemistry. Importantly, bioorthogonal labeling method presented strong signal intensity with relatively low cytotoxicity and the amounts of azide groups and cyclooctyne modified agent could be easily controlled by feeding different amounts of Ac4ManNAz and cyclooctyne modified agent to the cell culture system. In chapter 2, DBCO-Cy5-labeled chondrocytes seeded on 3D scaffold were subcutaneously implanted ...
Looking for online definition of Azides in the Medical Dictionary? Azides explanation free. What is Azides? Meaning of Azides medical term. What does Azides mean?
Photo-activation of the hydrophobic membrane probe 1, 5 iodonaphthylazide (INA) by irradiation with UV light (310-380 nm) results in the covalent modification of transmembrane anchors of membrane proteins. This unique selectivity of INA towards the transmembrane anchor has been exploited to specifically label proteins inserted in membranes. Previously, we have demonstrated that photo-activation of INA in enveloped viruses resulted in the inhibition of viral membrane protein-induced membrane fusion and viral entry into cells. In this study we show that photo-activation of INA in various cell lines, including those over-expressing the multi-drug resistance transporters MRP1 or Pgp, leads to cell death. We analyzed mechanisms of cell killing by INA-UV treatment. The effects of INA-UV treatment on signaling via various cell surface receptors, on the activity of the multi-drug resistance transporter MRP1 and on membrane protein lateral mobility were also investigated. INA treatment of various cell lines
Alfa Aesar™ BLOTTO in PBS, with 0.02% sodium azide 250mL Alfa Aesar™ BLOTTO in PBS, with 0.02% sodium azide Blocking Buffers for Protein Methods
TY - JOUR. T1 - MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes. AU - Er, Jun Cheng. AU - Tang, Mui Kee. AU - Chia, Chee Geng. AU - Liew, Huimin. AU - Vendrell, Marc. AU - Chang, Young-Tae. PY - 2013. Y1 - 2013. N2 - A novel class of triazole-derivatized BODIPY compounds have been synthesized on solid-phase by employing mild reaction conditions based on the copper-catalyzed azide-alkyne cycloaddition. The resulting BODIPY-triazoles exhibited MegaStokes shifts (up to 160 nm) and remarkable environmentally sensitive quantum yield increments that asserted their potential as turn-on fluorescent sensors. Out of a library of 120 compounds, we identified BDC-9 as a fluorescent chemosensor with high sensitivity and remarkable species-selectivity towards human serum albumin. These results validate MegaStokes BODIPY dyes as new fluorophores for the development of environmentally sensitive fluorescent probes.. AB - A novel class of triazole-derivatized BODIPY compounds ...
Severn Biotech, Limited PBS (1X) With sodium 0.1% Azide - Phosphate Buffered Saline 1x PBS with 0.1%w/v Sodium Azide. (1X PBS with Azide)This ubiquitous buffer is supplied with the preservative sodium azide already incorporated into the solution. Supplied 0.2 micron filtered in a ready to use format.For use in immunology, molecular biology and other life science techniques as a storage
Staudinger reaction The Staudinger reaction or Staudinger reduction is a chemical reaction in which the combination of an azide with a phosphine or phosphite
We have synthesized a new class of photoaffinity analogs, 2,3-O-(2,4,6-trinitrophenyl)-8-azido-ATP, -ADP and -AMP (TNP- 8N₃ATP, -ADP and -AMP), and their radiolabeled derivatives, and characterized their interaction with the sarcoplasmic reticulum Ca²⁺-ATPase. The TNP-8N₃-nucleotides were synthesized from ATP in three steps involving bromination in the 8-position of the adenine ring followed by displacement with an azido group and then trinitrophenylation of the resulting 8N₃-nucleotide with TNBS. Inclusion of the oxidizing agent, DTNB, in the final reaction was found to be necessary to prevent reduction of the azido group by the released sulfite anion and also elevated the yield of trinitrophenylation to about 80%. Purity was determined spectrophotometrically, as well as by anion exchange TLC and reversed phase HPLC. In the dark, the compounds were found to display most of the features of the parent TNP-nucleotides and interacted with the Ca²⁺-ATPase in a similar way. When ...
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Pegylation using heterotelechelic poly(ethylene glycol) (PEG) offers many possibilities to create high-performance molecules and materials. A versatile route is proposed to synthesize heterobifunctional PEG containing diverse combinations of azide, amine, thioacetate, thiol, pyridyl disulfide, as well as activated hydroxyl end groups. Asymmetric activation of one hydroxyl end group enables the heterobifunctionalization while applying selective monotosylation of linear, symmetrical PEG as a key step. The azide function is introduced by reacting monotosyl PEG with sodium azide. A thiol end group is obtained by reaction with sodium hydrosulfide. The activation of the hydroxyl end group and subsequent reaction with potassium carbonate/thioacetic acid yields a thioacetate end group. The hydrolysis of the thioester end group by ammonia in presence of 2,2′-dipyridyl disulfide provides PEG pyridyl disulfide. Amine terminated PEG is prepared either by reduction of the azide or by nucleophilic substitution of
Thanks Nick, this is exactly the kind of thing we should get from the safety officer, so that we can use these compounds safely. Rather than dopy comments like 1ml of 0.02% sodium azide is an explosive hazard. Mike. On Wed, 18 Jul 2001, Nick Theodorakis wrote: , In , ,Pine.SGI.4.33.0107182118570.2615940-100000 at mole.bio.cam.ac.uk,, , Michael Witty wrote: , , , ,On Wed, 18 Jul 2001, Warren Gallin wrote: , ,, So if you are flushing azide down a sink with metal plumbing, over a , ,, period of time a nasty explosive will build up in the traps. The poor , ,, plumber who cracks one of them can have a small grenade going off , in , ,, his/her face. This has actually happened, so not a theoretical , ,, consideration at all. , , , ,Dear Warren, , , please let me know about the paper or news report that has , ,described these two kinds of accident. I really am interested in , ,collecting examples of this kind of thing happening. , ,Mike. , , , , This is the closest thing I could find: , , ...
AIM: To investigate the neuroprotective effects of hyperoside (Hyp) on PC12 cells apoptosis induced by sodium azide and the mechanism of action. METHODS: To induce apoptosis, cultured PC12 cells was incubated with sodium azide 20 mmol·L⁻¹ for 3-24 h. Pretreatment with Hyp (0.01, 0.1 or 1 μmol·L⁻¹) for 4 h before sodium azide treatment. Cell viability was measured by MTT assay. The chromatin-specif ...
sample_1: JARID1C, [U-100% 15N], 1 mM; sodium phosphate 50 mM; sodium chloride 50 mM; sodium azide 0.02%; DTT 5 mM. sample_2: JARID1C, [U-13C; U-15N], 1 mM; sodium phosphate 50 mM; sodium chloride 50 mM; sodium azide 0.02%; DTT 5 mM. sample_3: JARID1C, [U-100% 15N], 1 mM; sodium phosphate 50 mM; sodium chloride 50 mM; sodium azide 0.02%; DTT 5 mM. sample_4: JARID1C, [U-13C; U-15N], 1 mM; sodium phosphate 50 mM; sodium chloride 50 mM; sodium azide 0.02%; DTT 5 mM. sample_conditions_1: pH: 6.0; pressure: 1 atm; temperature: 297 K. sample_conditions_2: pH*: 6.0; pressure: 1 atm; temperature: 297 K ...
sample_1: Get5 1 mM; Sgt2, [U-100% 13C; U-100% 15N], 2 mM; Bis-Tris 10 mM; L-arginine 50 mM; L-glutamic acid 50 mM; sodium azide 0.02%; H2O 90%; D2O 10%. sample_2: Get5 1 mM; Sgt2, [U-100% 13C; U-100% 15N], 2 mM; Bis-Tris 10 mM; L-arginine 50 mM; L-glutamic acid 50 mM; sodium azide 0.02%; polyacrylamide 3.5%; H2O 90%; D2O 10%. sample_3: Get5, [U-100% 13C; U-100% 15N], 1 mM; Sgt2 2 mM; Bis-Tris 10 mM; L-arginine 50 mM; L-glutamic acid 50 mM; sodium azide 0.02%; H2O 90%; D2O 10%. sample_4: Get5, [U-100% 13C; U-100% 15N], 1 mM; Sgt2 2 mM; Bis-Tris 10 mM; L-arginine 50 mM; L-glutamic acid 50 mM; sodium azide 0.02%; polyacrylamide 3.5%; H2O 90%; D2O 10%. sample_conditions_1: ionic strength: 0 mM; pH: 6.1; pressure: 1 atm; temperature: 310 K ...
First, the basics. Sodium azide (NaN3) is an odorless white solid that reacts violently with water, acid, or solid metal (lead or copper, for instance)....
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Aryl azides were treated with allenylmagnesium bromide to generate 1,5-disubstituted butynyl 1,2,3-triazoles in a domino fashion, which upon Cu(I) catalyzed 1,3-dipolar cycloaddition with aryl azides afforded novel bis-1,2,3-triazoles in quantitative yields. The final products were analyzed for their antimicrobial activities against a panel of bacterial and fungal strains which revealed the products to be potent antimicrobials.
Azido azetikoa konposatu organiko bat da. Formula kimiko hau du: CH3-COOH (C2H4O2).. Kolorerik gabeko likidoa da. Azido azetikoa ozpinaren osagai nagusia da. Azido ahultzat sailkatzen den arren, kontzentrazio altuetan korrosiboa da, eta gizakiaren larruazalari kalte egin diezaioke.. Azido azetiko sinpleena azido karboxilikoa da. Konposatu garrantzitsua da erreaktiboetan eta industria kimikoan, batez ere zeluloide azetatoa, argazki filma eta polibinil azetatoa ekoizteko. Zuntz sintetikoetan ere erabil daiteke. Etxebizitzetan, diluituta erabiltzen da. Kaltzioa kentzeko (E260) azidotasun erregulatzailetzat eta ongailutzat erabiltzen da.. ...
N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz) is an azide-containing metabolic glycoprotein labeling reagent that can be incorporated into the sialic acid biosynthesis pathway. The azide-modified protein is detected with either fluorescent alkynes or biotin alkyne. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.
Tetranitrogen is a neutrally charged polynitrogen allotrope of the chemical formula N 4 and consists of four nitrogen atoms. The tetranitrogen cation is the positively charged ion, N+ 4, which is more stable than the neutral tetranitrogen and is thus more studied. The structure, stability and properties of these molecules have been of great interest to research scientists in the last ten years.[when?] Polynitrogen compounds have been well known and characterized by chemists for many years. Molecular nitrogen (N 2) was first isolated by Daniel Rutherford in 1772 and the azide ion (N− 3) was discovered by Theodor Curtius in 1890. Discoveries of other related nitrogenous allotypes during the twentieth century include the aromatic molecule pentazole and the radical molecule N• 3. However, none of these complexes could be isolated or synthesized on a macroscopic scale like N 2 and azide; it was not until 1999 that a large scale synthesis was devised for a third nitrogen allotrope, the pentazenium ...
The synthesis and full characterisation of bifunctional β -amino acids that have side chains functionalised with terminal azides (S)-4 and (R)-4 or acetylenes 5 and 6 is reported for the first time. The building blocks incorporate a turn-inducing β -segment and a side chain that can be functionalised further, for example, through copper-catalysed Huisgen cycloaddition. Moreover, the corresponding α-amino acids 1 and 3 have been synthesised and characterised. All amino acid building blocks were of high optical purity as demonstrated by derivatisation and subsequent NMR analysis ...
Nota lepid. 36 (1): The status of Satyrus abramovi var. korlana Staudinger, 1901 (Nymphalidae) StaniSlav K. Korb a/ya 97, Nizhny Novgorod Russia; Received 14 August
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EXPERIMENTAL. The above experiments was conducted on a C80 at a heating rate of 0,5 K/min between room temperature and 280 °C. 76 mg of sample where placed inside a glass liner perfectly fitting the C80 high pressure measurement cell. The C80 was then cooled down, and the permanent decomposition gases were sent to a gas analyzer cell (FTIR).. RESULTS AND CONCLUSIONS. The complex two-step decomposition of o-trifluoromethyl phenyl azide was studied thanks to a combination of calorimetric, pressure, and evolved gas analysis data. Not only thermal and pressure hazards can be assessed, but also the risks linked with the formation of toxic gases - or straightforward information about decomposition mechanisms. For example, the strange silane - based gas detected by the FTIR was assigned to a reaction between the sample and the glass liner.. ...
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Many inorganic covalent azides (e.g., chlorine, bromine, and iodine azides) have been described. The azide anion behaves as a ... Heavy metal azides, such as lead azide are primary high explosives detonable when heated or shaken. Heavy-metal azides are ... containing the azide functional group. The dominant application of azides is as a propellant in air bags. Sodium azide is made ... 3 N2 Silver azide AgN3 and barium azide Ba(N3)2 are used similarly. Some organic azides are potential rocket propellants, an ...
... is a versatile precursor to other inorganic azide compounds, e.g., lead azide and silver azide, which are used in ... Lead and silver azide can be made via double displacement reaction with sodium azide and their respective nitrate (most ... These azides can be recovered from solution through careful desiccation. Sodium azide is a useful probe reagent and a ... Sodium azide increases cyclic GMP levels in the brain and liver by activation of guanylate cyclase. Sodium azide solutions ...
"Reaction between azide and nitronium ions. Formation and decomposition of nitryl azide". J. Am. Chem. Soc. 95 (3): 952-953. doi ... Nitryl azide (tetranitrogen dioxide) is an unstable nitrogen oxide consisting of a covalent nitrogen-nitrogen bond between a ... It has been detected by infrared spectroscopy as a short-lived product of the reaction between sodium azide and nitronium ... Zeng, Xiaoqing; Ge, Maofo; Sun, Zheng; Bian, Jiang; Wang, Dianxun (2007). "Gaseous nitryl azide N4O2: A joint theoretical and ...
Like most azides, it is explosive. Rubidium azide can be created by the reaction between rubidium sulfate and barium azide ... Rubidium azide is very sensitive to mechanical shock, with an impact sensitivity comparable to that of TNT. Like all azides, ... The II/I transition temperature of rubidium azide is within 2 °C of its melting point. Rubidium azide has a high pressure ... 3 H2O This formula is typically used to synthesize potassium azide from caustic potash. Rubidium azide has been investigated ...
... ((CH3)3SiN3) is a chemical compound used as a reagent in organic chemistry. Trimethylsilyl azide is ... Trimethylsilyl azide is incompatible with moisture, strong oxidizing agents, and strong acids. In 2014, a graduate student at ... It may be prepared by the reaction of trimethylsilyl chloride and sodium azide: TMSCl + NaN3 → TMSN3 + NaCl (TMS = (CH3)3Si) It ... L. Birkofer and P. Wegner (1988). "Trimethylsilyl azide". Organic Syntheses.; Collective Volume, vol. 6, p. 1030 Jafarzadeh, ...
... can be prepared by the reaction of tosyl chloride with sodium azide in aqueous acetone. Tosyl azide is one of the ... Tosyl azide is a reagent used in organic synthesis. Tosyl azide is used for the introduction of azide and diazo functional ... Diphenylphosphoryl azide Trifluoromethanesulfonyl azide Heydt, H.; Regitz, M.; Mapp, A. K.; Chen, B. (2008). "P-Toluenesulfonyl ... Curphey, T. J. (1981). "Preparation of p-Toluenesulfonyl Azide. A Cautionary Note". Organic Preparations and Procedures ...
... is sensitive to impact, in which it may detonate and ignite. Calcium azide at Chemister v t e (Articles without ... Calcium azide is a chemical compound with the formula Ca(N3)2. It can be obtained from a distilled reaction between hydrazoic ... Azides, Calcium compounds, All stub articles, Inorganic compound stubs). ...
Frierson, W. J.; Browne, A. W. (1943). "Chlorine Azide. II. Interaction of Chlorine Azide and Silver Azide. Azino Silver ... Chlorine azide is prepared by passing chlorine gas over silver azide, or by an addition of acetic acid to a solution of sodium ... Chlorine azide reacts explosively with 1,3-butadiene, ethane, ethene, methane, propane, phosphorus, silver azide, and sodium. ... Chlorine azide is extremely sensitive. It may explode, sometimes even without apparent provocation; it is thus too sensitive to ...
... Zn(N3)2 is an inorganic compound composed of zinc cations (Zn2+) and azide anions (N−3). It is a white, explosive ... It is easily hydrolyzed, and attempts to prepare it in aqueous solution resulted in the precipitation of basic azides Zn(OH)2-x ... Schulz, Axel; Villanger, Alexander (2016). "Binary Zinc Azides". Chemistry: A European Journal. 22 (6): 2032-2038. doi:10.1002/ ... 2 C2H6 Zinc azide is a coordination polymer which crystallizes in three polymorphs, all of which feature tetrahedral zinc ...
... may be prepared by the reaction of sodium azide with Br2. This reaction forms bromine azide and sodium bromide: ... Similar samples with azide molecules did not show such an effect. This shows bromine azide's unstable tendencies in that even ... Bromine azide is an explosive inorganic compound with the formula BrN3. It has been described as a crystal or a red liquid at ... Reactions involving bromine azide are difficult to work with. The molecule is very reactive and is known to explode easily. ...
Another azide regular is tosyl azide here in reaction with norbornadiene in a nitrogen insertion reaction: Some azides are ... The azide source is most often sodium azide (NaN3), although lithium azide (LiN3) has been demonstrated. Aliphatic alcohols ... trifluoromethanesulfonyl azide and imidazole-1-sulfonyl azide react with amines to give the corresponding azides. Diazo ... or under Mitsunobu conditions with diphenylphosphoryl azide (DPPA). Trimethylsilyl azide (CH3)3SiN3, and tributyltin azide ( ...
... can also be generated in situ by reacting iodine monochloride and sodium azide under conditions where it is not ... Iodine azide can be prepared from the reaction between silver azide and elemental iodine: AgN3 + I2 → IN3 + AgI Since silver ... Despite its explosive character, iodine azide has many practical uses in chemical synthesis. Similar to bromine azide, it can ... but even small traces of water cause the iodine azide to decompose, this synthesis is done by suspending the silver azide in ...
... or cesium azide is an inorganic compound of caesium and nitrogen. It is a salt of azide with the formula CsN3. ... H2O Caesium sulfate reacts with barium azide to form insoluble barium sulfate and caesium azide: Cs2SO4 + Ba(N3)2 → 2CsN3 + ... Caesium azide can be prepared from the neutralization reaction between hydrazoic acid and caesium hydroxide: CsOH + HN3 → CsN3 ... crystallizing in a tetragonal distorted caesium chloride structure where each azide ion coordinates to eight metal cations, and ...
... is a highly labile nitrogen oxide with chemical formula N3NO. Nitrosyl azide can be synthesized via the ... Lucien, Harold W. (1958). "The Preparation and Properties of Nitrosyl Azide". Journal of the American Chemical Society. 80 (17 ... Schulz, Axel; Tornieporth-Oetting, Inis C.; Klapötke, Thomas M. (1993). "Nitrosyl Azide, N4O, an Intrinsically Unstable Oxide ... following reaction of sodium azide and nitrosyl chloride at low temperatures: Below −50 °C, nitrosyl azide exists as a pale ...
... or hydrazine azide is a chemical compound with formula H 5N 5 or [N 2H+ 5][N− 3]. It is a salt of the ... At pressure of 40 GPa, hydrazinium azide decomposes yielding a linear nitrogen allotrope N 8 or N≡+N−−N−N=N−−N−+N≡N, that ... Reaction of hydrazinium azide with sulfuric acid gives quantitative yields of pure hydrazinediium sulfate and hydrazoic acid: [ ... 3.0.CO;2-O. Klapötke, T.; Peter S. White; Inis C. Tornieporth-Oetting (1996). "Reaction of hydrazinium azide with sulfuric acid ...
... , Be(N3)2, is an inorganic compound. It is a beryllium salt of hydrazoic acid HN3. Beryllium azide has been ... Wiberg, E.; Horst, M. (1954). "Beryllium azide, Be(N3)2". Zeitschrift für Naturforschung B. 9: 502. NIOSH Pocket Guide to ... 2 CH4 IR and Raman spectra suggest that beryllium azide consists of infinite chains, with tetrahedrally coordinated Be2+ ions ... "Synthesis and spectroscopic characterization of beryllium azide and two derivatives". Main Group Metal Chemistry. 22 (6): 357- ...
DPPA is very toxic and a potential explosive like most other azide compounds. Tosyl azide Trifluoromethanesulfonyl azide ... with expulsion of the azide ion. The latter then attacks the carbonyl carbon atom, to give the acyl azide and loss of the ... Finally, the acyl azide reacts in the normal manner to give the urethane. Studies show that DPPA reacts with amines giving the ... Diphenylphosphoryl azide (DPPA) is an organic compound. It is widely used as a reagent in the synthesis of other organic ...
Like sodium azide, potassium azide is very toxic. The TLV of the related sodium azide is 0.07 ppm. The toxicity of azides arise ... Potassium azide is the inorganic compound having the formula KN3. It is a white, water-soluble salt. It is used as a reagent in ... The azide is bound to eight cations in an eclipsed orientation. The cations are bound to eight terminal N centers. KN3 is ... The decomposition temperatures of the alkali metal azides are: NaN3 (275 °C), KN3 (355 °C), RbN3 (395 °C), CsN3 (390 °C). Under ...
... can be prepared treating an aqueous solution of thallium(I) sulfate with sodium azide. Thallium azide will ... The azide is bound to eight cations in an eclipsed orientation. The cations are bound to eight terminal N centers. All thallium ... Thallium azide, TlN3, is a yellow-brown crystalline solid poorly soluble in water. Although it is not nearly as sensitive to ... Mauer F.A.; Hubbard C.R.; Hahn T.A. (1973). "Thermal expansion and low temperature phase transition of thallous azide". J. Chem ...
... can be prepared by treating an aqueous solution of silver nitrate with sodium azide. The silver azide precipitates ... Silver azide is the chemical compound with the formula AgN3. It is a silver(I) salt of hydrazoic acid. It forms a colorless ... Pure silver azide explodes at 340 °C, but the presence of impurities lowers this down to 270 °C. This reaction has a lower ... Correspondingly, each end of each azide ligand is connected to a pair of Ag+ centers. The structure consists of two-dimensional ...
... , N3CN or CN4, is an azide compound of carbon and nitrogen which is an oily, colourless liquid at room ... "Cycloaddition of sulfonyl azides and cyanogen azide to enamines. Quantum-chemical calculations concerning the spontaneous ... Cyanogen azide is a primary explosive, although it is far too unstable for practical use as an explosive and is extremely ... It can be synthesised at below room temperature from the reaction of sodium azide with either cyanogen chloride or cyanogen ...
... is ionic, meaning it consists of ammonium cation [NH4]+ and azide anion N−3, therefore its formula is [NH4]+[N3 ... Ammonium azide contains about 93% nitrogen by mass. Frevel, Ludo K. (1 January 1936). "The Crystal Structure of Ammonium Azide ... Ammonium azide is the chemical compound with the formula [NH4]N3, being the salt of ammonia and hydrazoic acid. Like other ... Salim de Amorim, Helio; do Amaral, M. R.; Pattison P.; Ludka I. P.; Mendes, J. C. (2002). "Ammonium azide: A Commented Example ...
... can be made by reacting hydrazoic acid and fluorine gas. Another way to form it is by reacting sodium azide with ... Fluorine azide or triazadienyl fluoride is a yellow green gas composed of nitrogen and fluorine with formula FN3. It is counted ... Fluorine azide decomposes without explosion at normal temperatures to make dinitrogen difluoride: 2 FN3 → N2F2 + 2 N2. At ... Seder, T.A.; D.J. Benard (1991). "The decomposition of condensed phase fluorine azide". Combustion and Flame. 85 (3-4): 353-362 ...
Molecular Structure and Ionization Energies of Azides: An ab initio Study of Hydrazoic Acid, Methyl Azide and Ethyl Azide". ... Ethyl azide is used for organic synthesis. Campbell, H. C.; Rice, O. K. (1935). "The Explosion of Ethyl Azide". Journal of the ... Ethyl azide (CH3CH2N3) is an explosive compound sensitive to rapid heating, shock or impact. It has exploded when heated to ... Rice, O. K.; Campbell, H. C. (1939). "The Explosion of Ethyl Azide in the Presence of Diethyl Ether". The Journal of Chemical ...
... generally converts amines to azides. Tosyl azide Diphenylphosphoryl azide Sulfuryl diazide C. J ... Trifluoromethanesulfonyl azide or triflyl azide CF3SO2N3 is an organic azide used as a reagent in organic synthesis. ... Cavender & V. J. Shiner (1972). "Trifluoromethanesulfonyl azide. Its reaction with alkyl amines to form alkyl azides". The ... Trifluoromethanesulfonyl azide is not commercially available. It is prepared before use by reacting trifluoromethanesulfonic ...
... is an inorganic azide with the formula Ba(N3)2. It is a barium salt of hydrazoic acid. Like most azides, it is ... It is less sensitive to mechanical shock than lead azide. Barium azide may be prepared by reacting sodium azide with a soluble ... Barium azide can be used to make azides of magnesium, sodium, potassium, lithium, rubidium and zinc with their respective ... Care should be taken to prevent large crystals from forming in the solution as barium azide crystals will explode if subjected ...
... is the lithium salt of hydrazoic acid. It is an unstable and toxic compound that decomposes into lithium and ... It can be prepared by metathesis reaction between sodium azide and lithium nitrate or lithium sulfate solutions: NaN3 + LiNO3 ... LiN3 + NaNO3 2 NaN3 + Li2SO4 → 2 LiN3 + Na2SO4 It can also be prepared by reacting lithium sulfate with barium azide. Ba(N3)2 ... sodium and strontium azides". Acta Crystallogr. B. 24 (2): 262-269. doi:10.1107/S0567740868002062. Hála, Jiri. "IUPAC-NIST ...
... is an organic compound with the formula C6H5N3. It is one of the prototypical organic azides. It is a pale yellow ... As with many other azides, phenyl azide poses a risk of explosion, so a protective blast shield is recommended during ... In a classic example of click chemistry, phenyl azide and phenylacetylene react to give diphenyl triazole. Phenyl azide reacts ... The structure consists of a linear azide substituent bound to a phenyl group. The C−N=N angle is approximately 120°. Phenyl ...
In some applications, tributyltin azide has been replaced by the less toxic trioctyltin azide and organoaluminium azides. Lower ... Tributyltin azide is synthesized by the salt metathesis reaction of tributyltin chloride and sodium azide. It is a reagent used ... Tri-higher alkyl tin azide and its use, United States Patent 5484955 Saito, S (1989). "Highly nucleophilic tributyltin azide in ... Tributyltin azide is an organotin compound with the formula (C4H9)3SnN3. It is a colorless solid although older samples can ...
It is a white solid and it is the simplest organic azide. Methyl azide can be prepared by the methylation of sodium azide, for ... Methyl azide is stable at ambient temperature but may explode when heated. Presence of mercury increases the sensitivity to ... Quinto-Hernandez, A.; Wodtke, A. M.; Bennett, C. J.; Kim, Y. S.; Kaiser, R. I. (2011). "On the Interaction of Methyl Azide ( ... It decomposes in a first-order reaction: CH3N3 → CH3N + N2 Methyl azide might be a potential precursor in the synthesis of ...
Sodium azide exists as an odorless white solid. When mixed with water or an acid it changes rapidly to a toxic gas with a sharp ... Exposure to sodium azide can be fatal.. *METHODS OF DISSEMINATION: *Indoor Air: Sodium azide can be released into indoor air as ... Food: Sodium azide can be used to contaminate food.. *Outdoor Air: Sodium azide can be released into outdoor air as fine ... DESCRIPTION: Sodium azide exists as an odorless white solid. When mixed with water or an acid it changes rapidly to a toxic gas ...
How you could be exposed to sodium azide *Following release of sodium azide into water, you could be exposed to sodium azide by ... Where sodium azide is found and how it is used *Sodium azide is best known as the chemical found in automobile airbags. An ... How sodium azide works *The seriousness of poisoning caused by sodium azide depends on the amount, route, and length of time of ... What sodium azide is *Sodium azide is a rapidly acting, potentially deadly chemical that exists as an odorless white solid. ...
The majority of exposures to sodium azide occur by inhalation. Signs and symptoms of sodium azide poisoning include lethargy or ... Biologic: A case in which sodium azide in serum is detected, as determined by a commercial laboratory. ... Environmental: Detection of sodium azide in environmental samples, as determined by FDA. ... exists for sodium azide exposure, or an epidemiologic link exists between this case and a laboratory-confirmed case. ...
How you could be exposed to sodium azide *Following release of sodium azide into water, you could be exposed to sodium azide by ... Where sodium azide is found and how it is used *Sodium azide is best known as the chemical found in automobile airbags. An ... How sodium azide works *The seriousness of poisoning caused by sodium azide depends on the amount, route, and length of time of ... What sodium azide is *Sodium azide is a rapidly acting, potentially deadly chemical that exists as an odorless white solid. ...
BSA and Azide free. Validated in WB, IHC and tested in Mouse, Rat, Human. Cited in 11 publication(s). ... Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and ... This image was made using ab76541 which is the same antibody as ab220799 with BSA and Azide. Immunohistochemistry (Formalin/PFA ... This image was made using ab76541 which is the same antibody as ab220799 with BSA and Azide. Immunohistochemistry (Formalin/PFA ...
In previous works, we have identified chelating azides, in particular 2-picolyl azide, as ... This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide- ... In previous works, we have identified chelating azides, in particular 2-picolyl azide, as "privileged" azide substrates with ... The azide reaction partner is chosen purposefully to be the chelating 2-picolyl azide. Therefore, the identified fast-reacting ...
The glycidyl azide polymer (GAP) is an important type of energetic polymer and is considered to be the most promising candidate ... Glycidyl azide polymer-based polyurethane vitrimers with disulfide chain extenders Y. Hu, G. Tang, Y. Luo, S. Chi and X. Li, ... The glycidyl azide polymer (GAP) is an important type of energetic polymer and is considered to be the most promising candidate ...
Subject: Re: Glove chart that lists sodium azide?. Date: Wed, 30 Nov 2011 09:56:18 -0500. Author: "Samuella B. Sigmann" Next by ... Subject: Re: Glove chart that lists sodium azide?. Date: Wed, 30 Nov 2011 20:33:46 -0500. Author: "Samuella B. Sigmann" ... Subject: Re: Glove chart that lists sodium azide?. X-To: DCHAS-L In-Reply-To: ,4ED5AD92.3000500**At_Symbol_Here**appstate.edu, ... Does anyone have a chart that lists the permeation times for sodium azide? Thanks,. Sammye. -- ...
Milk? Sugar? Sodium azide? October 26, 2009 •By Chemjobber •In Uncategorized According to a number of sources (including the ... My understanding of sodium azide is that it can be lethal, so it must have been a relatively low dose. (Thank God for small ... One of the method to determine sodium azide in chemical laboratory or food testing laboratory is the ion chromatography ... so what method did the investigating chemist / toxicologist use to identify the sodium azide for proof of identity (spectra?) ...
Click Reagents by Chemistry Azide Reagents Fluorescent Dyes ... Cy5.5-Azide. Picolyl-Azide-Cy5.5. near-IR. Cy7. Picolyl-Azide- ... also known as Alexa Fluor® 488-Picolyl-Azide. 5/6-Carboxyrhodamine 110-PEG3-Azide CLK-AZ105. Abs/Em = 501/525 nm. Azide-Fluor ... 5/6-TAMRA-PEG3-Azide CLK-AZ109. Abs/Em = 546/565 nm. 5/6-Carboxytetramethylrhodamine-PEG3-Azide, Azide-Fluor 545 ... Picolyl-Azide-Sulfo-Cy3 CLK-1178. Abs/Em = 555/565 nm. AF546-Azide CLK-1283. Abs/Em = 554/570 nm. also known as Alexa Fluor® ...
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... International Journal of Plant Breeding ... Effect of Sodium Azide on the Growth and Variability Induction in Helianthus annuus L.. ... Abstract: Seeds of Helianthus annuus cultivars Giza 1 and 102 were soaked in sodium azide solutions with the concentrations of ... The two genotypes Giza 1 and 102 produced a wide range of response to sodium azide concentrations by the studied traits. ...
Reactions of vinyl azides with monocyclic cyclopropanols provided pyridines in the presence of Mn(acac)3, whereas those with ... Mn(III)-Mediated Reactions of Cyclopropanols with Vinyl Azides: Synthesis of Pyridine and 2-Azabicyclo[3.3.1]non-2-en-1-ol ...
az·ide (ăzīd, āzīd). Share: Tweet. ...
"The photolysis of calcium, barium, strontium and lithium azides and the co-irradiated decomposition of calcium azide." Thesis ... The photolysis of calcium, barium, strontium and lithium azides and the co-irradiated decomposition of calcium azide. Login ... Analogous results were obtained for all four azides at low temperatures and the results obtained for calcium and lithium azides ... The photolysis of calcium, barium, strontium and lithium azides and the co-irradiated decomposition of calcium azide. [Thesis ...
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... researchers from Leibniz University Hannover report the multistep flow synthesis of vinyl azides and their application in the ... The intermediate 2-iodo azides are subjected to a DBU-mediated polymer-supported elimination step yielding vinyl azides in good ... The synthesis relies on a stable polymer-bound equivalent of iodine azide that serves to carry out 1,2-functionalization of ... Multistep Flow Synthesis of Vinyl Azides and their use in the Copper-Catalyzed Huisgen-type Cycloaddition under Inductive- ...
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... s for interactome profiling. Debasis Dey, Babu Sudhamalla, ...
How you could be exposed to sodium azide *Following release of sodium azide into water, you could be exposed to sodium azide by ... Where sodium azide is found and how it is used *Sodium azide is best known as the chemical found in automobile airbags. An ... How sodium azide works *The seriousness of poisoning caused by sodium azide depends on the amount, route, and length of time of ... What sodium azide is *Sodium azide is a rapidly acting, potentially deadly chemical that exists as an odorless white solid. ...
Whereas the azide-alkyne approach may be suffered from the potential danger in handling azides on large scale, the ATRP graft ... In the first strategy, thermal azide-alkyne Huisgen cycloaddition was utilized to attach electron-poor acetylenediamides using ... Internal Plasticization of Poly(Vinyl Chloride) using Thermal Azide-Alkyne Huisgen Cycloaddition and Copper-Mediated Atom ... These internal tetra-plasticizers were synthesized and attached to PVC-azide in three simple synthetic steps. ...
PA particles were surface modified through the "click" transformation of an azide-terminated indocyanine green (azICG), an NIR ... For an oxadiazole containing molecule (AO), an azide-modified coumarin 6 (AD1) and a polyethylene glycol modied naphthalimide- ... Rungta, Parul, "Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition for the Surface Modification of ... Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition for the Surface Modification of Colloidal ...
Biochempeg offers high purity N3-PEG-SH, Heterobifunctional PEG and even custom PEG synthesis.
... and following click chemistry with diverse azide compounds. The benefits of the FTR have been demonstrated by its specificity, ... and following click chemistry with diverse azide compounds. The benefits of the FTR have been demonstrated by its specificity, ... and following click chemistry with diverse azide compounds. The benefits of the FTR have been demonstrated by its specificity, ... and following click chemistry with diverse azide compounds. The benefits of the FTR have been demonstrated by its specificity, ...
Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of(18)F- ... Corrigendum: Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation ...
Is sodium azide legal to obtain, like SN is? ... Another article: [Sodium azide: a review of biological effects ... Azide is listed as quicker than SN but no time frame is clear. I think Azide is a better way to go if the side effects are ... Sodium azide and peacefulness. Scientific article: Human Health Effects of Sodium Azide Exposure: A Literature Review and ... Death is reached faster with sodium azide than with SN, though, so sodium azide may or may not be more painful to you depending ...
Craniofacial bones shield important organs, carry out necessary physiological capabilities, and form facial identification. Crucial-size defects (CSDs) in calvarial bones, which wont heal spontaneously, are brought on by trauma, congenital defects, or tumor resections. They pose an excellent. ...
  • Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. (abcam.com)
  • PBS with 0.02% sodium azide, 50% glycerol, pH7.3. (prosci-inc.com)
  • PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. (origene.com)
  • Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. (bdbiosciences.com)
  • Rabbit Anti SAFB Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Immunofluorescence) from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.02% sodium azide, 50% glycerol, pH7.3 This antibody has been affinity purified. (innov-research.com)
  • PBS with 0.1% sodium azide and 50% glycerol pH 7.3. (novoprolabs.com)
  • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. (afgsci.com)
  • Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. (ewmccall.com)
  • Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. (diagenox.com)
  • Storage: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. (afsbio.com)
  • Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (BSA Country of Origin USA). (cytekbio.com)
  • Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide. (biod.co.kr)
  • This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. (mdpi.com)
  • In the first strategy, thermal azide-alkyne Huisgen cycloaddition was utilized to attach electron-poor acetylenediamides using a branched glutamic acid linker to azidized PVC, incorporating four plasticizing moieties per attachment point. (escholarship.org)
  • Both copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) work with this product. (quantabiodesign.com)
  • They can undergo cluster-surface strain -promoted alkyne - azide cycloaddition (CS-SPAAC) chemistry with complementary strained- alkynes . (bvsalud.org)
  • Sodium azide is used as a chemical preservative in hospitals and laboratories. (cdc.gov)
  • Product contains sodium azide as a preservative. (hytest.fi)
  • In previous works, we have identified chelating azides, in particular 2-picolyl azide, as "privileged" azide substrates with high CuAAC reactivity. (mdpi.com)
  • (Picolyl-) Azides of fluorescent dyes can be used for the fluorescent labeling of terminal Alkyne and strained Alknye (e.g DBCO)-labeled molecules via Cu(I)-catalyzed Alknye-Azide (CUAAC) or Cu(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC) reaction, respectively. (jenabioscience.com)
  • APDye 800 Picolyl Azide is an advanced fluorescent probe that incorporates a copper chelating motif to increase the effective concentration of Cu(I) at the reaction site, thereby increasing the efficiency of the CuAAC reaction for faster and more Biocompatible CuAAC labeling. (axispharm.com)
  • The far-red fluorescent Cy5 azide can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (clickchemistrytools.com)
  • The rate of CuAAC reaction depends on concentrations of all reagents, including copper, thus the raise of the effective copper concentration at the reaction site dramatically increase the rate of CuAAC reaction without the need to increase concentration of azide reagent and copper. (fluoroprobes.com)
  • Although the amount of sodium azide is very small appropriate care must be taken when handling this product. (hytest.fi)
  • Signs and symptoms of sodium azide poisoning include lethargy or coma (possibly sudden collapse), dyspnea, tachypnea, tachycardia, and hypotension. (cdc.gov)
  • Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. (xcessbio.com)
  • Reactions of vinyl azides with monocyclic cyclopropanols provided pyridines in the presence of Mn(acac) 3 , whereas those with bicyclic cyclopropanols led to the formation of 2-azabicyclo[3.3.1]non-2-en-1-ol derivatives using a catalytic amount of Mn(acac) 3 . (organic-chemistry.org)
  • The intermediate 2-iodo azides are subjected to a DBU-mediated polymer-supported elimination step yielding vinyl azides in good yield. (technologynetworks.com)
  • The synthesis relies on a stable polymer-bound equivalent of iodine azide that serves to carry out 1,2-functionalization of alkenes in a telescope flow protocol. (technologynetworks.com)
  • MB™ 488 Picolyl Azide is an advanced probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site. (fluoroprobes.com)
  • In addition, the use of picolyl azide instead of conventional azide allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labeling. (fluoroprobes.com)
  • To fine-tune structure-property correlations of thiolate-protected gold nanoclusters through post-assembly surface modifications, we report the synthesis of the o, m, and p regioisomeric forms of the anionic azide -functionalized [Au25 (SCH2 CH2 -C6 H4 -N3 )18 ]1- platform. (bvsalud.org)
  • The staining solution was removed, cells were rinsed with PBS/3% BSA, and 0.05% sodium azide and PBS. (cellimagelibrary.org)
  • Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. (bdbiosciences.com)
  • The internal modification of RNA has been successfully achieved by the functionality transfer reaction (FTR) and following click chemistry with diverse azide compounds. (elsevier.com)
  • The click reaction involves a copper-catalyzed triazole formation from an azide and an alkyne. (abpbio.com)
  • The Andy Fluor™ 594 azide is reactive with terminal alkyne via a copper-catalyzed click reaction that allows the subsequent visualization by fluorescence spectroscopy. (abpbio.com)
  • The reaction in the microcuvette is a modified azide-methaemoglobinn reaction. (who.int)
  • Cy5 Azide is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. (clickchemistrytools.com)
  • Sodium azide can be absorbed into the body by inhalation, ingestion, skin contact, or eye contact. (cdc.gov)
  • The majority of exposures to sodium azide occur by inhalation. (cdc.gov)
  • Persons who work on automobiles regularly are at an increased risk of exposure to sodium azide, which is used as a propellant in airbags. (cdc.gov)
  • Exposure to sodium azide can be fatal. (cdc.gov)
  • Ingestion is an important route of exposure to solid sodium azide. (cdc.gov)
  • The seriousness of poisoning caused by sodium azide depends on the amount, route, and length of time of exposure, as well as the age and preexisting medical condition of the person exposed. (cdc.gov)
  • Moving to an area with fresh air is a good way to reduce the possibility of death from exposure to sodium azide. (cdc.gov)
  • A clinically compatible case in which a high index of suspicion (credible threat or patient history regarding location and time) exists for sodium azide exposure, or an epidemiologic link exists between this case and a laboratory-confirmed case. (cdc.gov)
  • review of the literature from 1927 to 2002 on human exposure to sodium azide and its health effects. (sanctioned-suicide.org)
  • Agricultural: If sodium azide is released into the air as fine particles (aerosol), it has the potential to contaminate agricultural products. (cdc.gov)
  • Whereas the azide-alkyne approach may be suffered from the potential danger in handling azides on large scale, the ATRP graft copolymerization approach is expected to be very attractive to industry, to afford internally plasticized PVC products with reliable and durable physical properties. (escholarship.org)
  • Custom Formulations: azide free, endotoxin testing & endotoxin removal. (prosci-inc.com)
  • Controlling the Structure, Properties and Surface Reactivity of Clickable Azide-Functionalized Au 25 (SR) 18 Nanocluster Platforms Through Regioisomeric Ligand Modifications. (bvsalud.org)
  • When it is mixed with water or an acid, sodium azide changes rapidly to a toxic gas with a pungent (sharp) odor. (cdc.gov)
  • Low Endotoxin/Azide Free Anti-Mouse CD11b antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and blocking assays. (southernbiotech.com)
  • The low endotoxin, azide-free antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. (mdbioproducts.com)
  • Form: The low endotoxin, azide-free antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. (mdbioproducts.com)
  • Mouse T1/ST2 (IL-33 R) monoclonal antibody (Clone DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped), azide-free, for the identific. (mdbioproducts.com)
  • Cytodiagnostics Azide functionalized gold nanoparticles are suitable for covalent conjugation of any molecule with a terminal alkyne through click chemistry. (cytodiagnostics.com)
  • 14-17 An azide-carrying cofactor, for example, enables the sequence-specific, covalent introduction of azide groups into DNA. (rsc.org)
  • Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. (bdbiosciences.com)
  • For an oxadiazole containing molecule (AO), an azide-modified coumarin 6 (AD1) and a polyethylene glycol modied naphthalimide-based emitter (AD2), respectively, an 84%, 17% and 5% increase in the grafting densities were observed, when the transformation was performed in the presence of β-CD. (clemson.edu)
  • Azide can be used for molecule conjugation by click chemistry, andthiol can react with -SH or maleimide groups. (nanosoftpolymers.com)
  • Seeds of Helianthus annuus cultivars Giza 1 and 102 were soaked in sodium azide solutions with the concentrations of 0, 100, 200, 300, 400 and 500 ppm for 4 h. (scialert.net)
  • The two genotypes Giza 1 and 102 produced a wide range of response to sodium azide concentrations by the studied traits. (scialert.net)
  • Not only did low concentrations of sodium-azide or BSA interfere with the CL assay, but this interference was not completely eliminated when the TNFa was dialyzed. (cdc.gov)
  • In surveys, blood haemoglobin concentrations are typically measured using the direct cyanmethemoglobin method in a laboratory or with a portable, battery-operated, haemoglobin photometer in the field that uses the azide-methaemoglobin method. (who.int)
  • Following contamination of food with sodium azide, you could be exposed to sodium azide by eating the contaminated food. (cdc.gov)
  • Indoor Air: Sodium azide can be released into indoor air as fine particles (aerosol). (cdc.gov)
  • PA particles were surface modified through the "click" transformation of an azide-terminated indocyanine green (azICG), an NIR emitter, and poly(ethylene glycol) (azPEG) chains of various molecular weights. (clemson.edu)
  • Azide-Poly-L-lysine-Thiol (N3-PLL-SH) is a linear heterobifunctional poly(L-lysine) with an azide and a thiol group on the PLL ends. (nanosoftpolymers.com)
  • Azide free recombinant murine TNFa further enhanced hydrogen-peroxide associated CL, while recombinant human TNFa which contained sodium-azide was an effective quenching agent for CL. (cdc.gov)
  • In one case, sodium azide was poured into a drain, where it exploded and the toxic gas was inhaled (breathed in). (cdc.gov)
  • An explosion involving sodium azide may cause burn injury as well as expose people to the toxic gas, hydrozoic acid. (cdc.gov)
  • Breathing the gas that is formed from sodium azide causes the most harm, but ingesting (swallowing) sodium azide can be toxic as well. (cdc.gov)
  • 2012). Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling. (fluoroprobes.com)
  • m-dPEG ® 24 -azide, product number 10540, also known as azido-m-dPEG ® 24 , is a monodispersed PEG product used in click chemistry applications. (quantabiodesign.com)
  • The DNA methyltransferase M.TaqI labels the DNA nanostructures with azide groups, which serve as universal attachment points via click chemistry. (rsc.org)
  • Sodium azide is also used in detonators and other explosives. (cdc.gov)
  • Detection of sodium azide in environmental samples, as determined by FDA. (cdc.gov)
  • In summary, the introduction of a picolyl moiety into an azide probe leads to a substantial increase in the sensitivity of alkyne detection. (fluoroprobes.com)
  • Sodium nitrite converts haemoglobin to methaemoglobin which, together with sodium azide, gives azidemethaemoglobin. (who.int)