AzetinesResearch: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Egypt: A country in northern Africa, bordering the Mediterranean Sea, between Libya and the Gaza Strip, and the Red Sea north of Sudan, and includes the Asian Sinai Peninsula Its capital is Cairo.Research Personnel: Those individuals engaged in research.Research Support as Topic: Financial support of research activities.Schistosomiasis: Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Molluscacides: Agents destructive to snails and other mollusks.Citrobacter freundii: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria found in humans and other animals including MAMMALS; BIRDS; REPTILES; and AMPHIBIANS. It has also been isolated from SOIL and WATER as well as from clinical specimens such as URINE; THROAT; SPUTUM; BLOOD; and wound swabs as an opportunistic pathogen.Cardiac Myosins: Myosin type II isoforms found in cardiac muscle.Sarcomeres: The repeating contractile units of the MYOFIBRIL, delimited by Z bands along its length.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Cardiomyopathy, Hypertrophic: A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).Chemistry, Analytic: The branch of chemistry dealing with detection (qualitative) and determination (quantitative) of substances. (Grant & Hackh's Chemical Dictionary, 5th ed)Myosins: A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.Hemagglutinins, Viral: Specific hemagglutinin subtypes encoded by VIRUSES.Influenza A virus: The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.Influenza, Human: An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.Hemagglutinin Glycoproteins, Influenza Virus: Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.Hemagglutinins: Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.Influenza A Virus, H1N1 Subtype: A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.Influenza A Virus, H3N2 Subtype: A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 3 and neuraminidase 2. The H3N2 subtype was responsible for the Hong Kong flu pandemic of 1968.

Effect of L-azetidine-2-carboxylic acid on glycosylations of collagen in chick-embryo tendon cells. (1/17)

The glycosylations of hydroxylysine during collagen biosynthesis in isolated chick-embryo tendon cells were studied by using pulse-chase labelling experiments with [14C]-lysine. The hydroxylation of lysine and the glycosylations of hydroxylysine continued after a 5 min pulse label for up to about 10 min during the chase period. These data differ from those obtained previously in isolated chick-embryo cartilage cells, in which, after a similar 5 min pulse label, these reactions continued during the chase period for up to about 20 min. The collagen synthesized by the isolated chick-embryo tendon cells differed markedly from the type I collagen of adult tissues in its degree of hydroxylation of lysine residues and glycosylations of hydroxylysine residues. When the isolated tendon cells were incubated in the presence of L-azetidine-2-carboxylic acid, the degree of glycosylations of hydroxylysine during the first 10 min of the chase period was identical with that in cells incubated without thcarboxylic acid for at least 60 min, whereas no additional glycosylations took place in the control cells after the 10 min time-point. As a consequence, the collagen synthesized in the presence of this compound contained more carbohydrate than did the collagen synthesized by the control cells. Additional experiments indicated that azetidine-2-carboxylic acid did not increase the collagen glycosyltransferase activities in the tendon cells or the rate of glycosylation reactions when added directly to the enzyme incubation mixture. Control experiments with colchicine indicated that the delay in the rate of collagen secretion, which was observed in the presence of azetidine-2-carboxylic acid, did not in itself affect the degree of glycosylations of collagen. The results thus suggest that the increased glycosylations were due to inhibition of the collagen triple-helix formation, which is known to occur in the presence of azetidine-2-carboxylic acid.  (+info)

Incorporation of L-azetidine-2-carboxylic acid into hemoglobin in rabbit reticulocytes in vitro. (2/17)

L-Azetidine-2-carboxylic acid is the naturally occurring lower homologue of L-proline. Reticulocytes from anemic rabbits incubated with DL-[14-C]azetidine-2-carboxylic acid synthesized radiolabeled hemoglobin, which when isolated from cell lysates co-chromatographed with unlabeled hemoglobin on Sephadex G-100 columns. Amino acid analysis of hemoglobin from reticulocytes incubated with DL-[14-C]-azetidine-2-carboxylic acid suggested that the homologue was incorporated into hemoglobin intact and unaltered. Alternatively, another amino acid analogue, 1-aminocyclopentane-[1-14-C]carboxylic acid, which is purported to be a valine antagonist, was not incorporated into hemoglobin under these conditions. Incubation of reticulocytes with 1, 5, and 10 mM L-azetidine-2-carboxylic acid reduced L-[U-14-C]proline (0.10 mM) incorporation into hemoglobin by 25, 58, and 72%, respectively. Conversely, 1.45 and 145 muM L-proline reduced radiolabeled azetidine-2-carboxylic acid (0.8 mM) in corporation into hemoglobin by 45 and 92%, respectively. Incorporation of L-[U-14-C]leucine and L-[U-14-C]lysine (0.1 mM each) into hemoglobin was unaffected at these concentrations of L-azetidine-2-carboxylic acid. These results suggest that L-azetidine-2-carboxylic acid is incorporated into hemoglobin without reducing the rate of globin synthesis in rabbit reticulocytes in vitro. The alpha and beta chains of hemoglobin into which [14-C]azetidine-2-carboxylic acid had been incorporated in rabbit reticulocytes in vitro were resolved electrophoretically on sodium dodecyl sulfate-polyacrylamide gels. The ratio of total radioactivity in the alpha and beta chains separately extracted from gels was in good agreement with the known 7:4 ratio of prolyl residues in the respective chains. Autoradiograms of two-dimensional tryptic peptide maps of rabbit globin into which either [14-C]azetidine-2-carboxylic acid or [14-C]proline had been incorporated showed nearly identical patterns of radioactivity. These results suggest that azetidine-2-carboxylic acid substitutes specifically for prolyl residues during in vitro hemoglobin synthesis in rabbit reticulocytes.  (+info)

18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons. (3/17)

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Antihypertensive effect of CS-905, a novel dihydropyridine calcium blocker, in conscious hypertensive dogs. (4/17)

CS-905, (+-)-3-(1-diphenylmethylazetidin-3-yl)5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridine-dicarboxy lat e, is a novel dihydropyridine calcium blocker. Both CS-905 and nicardipine, when administered orally, produced a dose-dependent fall of blood pressure in conscious perinephritic hypertensive dogs. Unlike the hypotensive effect of nicardipine, that of CS-905 has a gradual onset and is long-lasting, with little increase in the heart rate and plasma renin activity (PRA). The lack of both tachycardia and increase of PRA is probably mostly due to the slow onset of antihypertensive action following CS-905.  (+info)

Generation and electrophile trapping of N-Boc-2-lithio-2-azetine: synthesis of 2-substituted 2-azetines. (5/17)

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Effects of a new thyrotropin-releasing hormone derivative on behavioral changes after focal cerebral ischemia in rats. (6/17)

We observed the effects of a new thyrotropin-releasing hormone derivative, YM-14673 (N alpha-[[(S)-4-oxo-2-azetidinyl]carbonyl]-L-histidyl-L-prolinamide dihydrate), on behavioral changes in rats for 3 weeks after focal cerebral ischemia. Under halothane anesthesia, the left middle cerebral artery was occluded via a transretro-orbital approach. YM-14673 was administered just after the operation and once a day for 3 weeks. Neurologic deficits, including hemiplegia and abnormal posture, and disturbance of passive avoidance learning were present in solvent-treated control rats for the entire 3 weeks. YM-14673 at 0.1 or 0.3 mg/kg i.p. or 1 mg/kg p.o. significantly accelerated the recovery of neurologic deficits and ameliorated cognitive disturbance compared with the solvent-treated controls although the drug at 0.1 and 0.3 mg/kg i.p. did not influence the size of the ischemic infarct. YM-14673 mitigated the behavioral disturbances in this model of chronic focal cerebral ischemia. We also discuss the suitability of this model for the evaluation of drugs.  (+info)

Beneficial renal effects of CS-905, a novel dihydropyridine calcium blocker, in SHR. (7/17)

CS-905 is a potent dihydropyridine calcium blocker that has a gradual and long-lasting antihypertensive action with little tachycardia in SHR. In this study, we investigated chronic and acute effects of CS-905 on renal functions in SHR. To examine the chronic effects, 23 week-old male SHR were treated with CS-905 (1 or 3 mg/kg/day, p.o.) or 0.3% CMC (carboxymethylcellulose). After the 15 week-treatment, the agent dose-relatedly lowered systolic blood pressure measured 24 hr after the final administration (184 +/- 2 and 173 +/- 3 mmHg at 1 and 3 mg/kg/day vs. 218 +/- 4 mmHg for the control group). Natriuresis and the reduction of urinary protein excretion were also observed in the CS-905 treated groups. Urinary NAG (N-acetyl-beta-D-glucosaminidase) activity tended to decrease, but not significantly. Histopathological changes observed in the SHR kidney were reduced by chronic treatment with CS-905. On a single oral administration in 38 week-old SHR, CS-905 caused natriuresis at a dose of 3 mg/kg, but did not affect urinary protein excretion and urinary NAG activity. These effects of CS-905 on renal functions may be beneficial in the treatment of hypertension.  (+info)

Interference with thyroid histogenesis by inhibitors of collagen synthesis. (8/17)

Histogenesis of thyroid follicles in the chick embryo begins with a penetration by cells of the mesenchymal capsule into a solid epithelial primordium. Before penetration occurs, slits containing fibrillar material form between the epithelial cells. The fibrillar material is an epithelial cell product as shown by its formation within channels that form in cultures of isolated epithelial primordia. The drugs L-azetidine-2-carboxylic acid (LACA) and alpha, alpha'-dipyridyl, which interfere with collagen synthesis, prevent the formation of fibrils in cultured epithelial primordia and in cultures of whole thyroids. Furthermore, mesenchymal cells do not invade when whole thyroid primordia are cultured in the presence of either drug. The effects of alpha, alpha'-dipyridyl are reversed by washing out the drug; the effects of LACA are reversed by incubation with equimolar or greater amounts of L-proline added to the medium along with the drug. The results are interpreted to mean that the fibrillar material is collagen of epithelial origin, that the collagen in some way plays a role in mesenchymal penetration of the epithelial primordium, and that the epithelium is responsible for the pattern of lobulation within the developing gland.  (+info)

Amlodipine causes marked coronary and peripheral arterial vasodilation (which leads to plasma leakage in dependent areas since the veins remain constricted). As happens with other dihydropyridine calcium blockers, this results in a small percentage of patients having a problem with pedal edema (Am J Med. 2004;116:35-43). The pedal edema is not related to congestive heart failure and responds only inconsistently to diuretics, but it is not harmful.Mungkin akan nmpk sedikit gemuk sbb berlaku edema/bengkak.. ...
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N-Boc-(2S,3S)-3-Amino-2-hydroxy-3-(3-methyl-phenyl)-propanoic acid/ACM959583950 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
chemBlink provides information about CAS # 55447-00-2, (S)-N-Boc-1-Naphthylalanine, N-tert-Butoxycarbonyl-1-naphthyl-L-alanine, molecular formula: C18H21NO4.
Founded in 2011, Suzhou Xinkai Bio-Medical Technology Co., Ltd. is located in Suzhou New District of Suzhou city in Jiangsu province. Xinkai focus is on the development of...
Founded in 2011, Suzhou Xinkai Bio-Medical Technology Co., Ltd. is located in Suzhou New District of Suzhou city in Jiangsu province. Xinkai focus is on the development of...
ortho-Lithiation of N-Boc-3-bromopyrroles (7b, 7d) with LDA in THF at −75°C, followed by reactions with ethyl formate gave exclusive C2-formylpyrroles (9b, 9c, 9d, 9e) in good yields. This methodology was applied to the synthesis of 3-(2-formyl-4-methyl-1-H-pyrrol-3-yl)propanoic acid (4a), a penultimate precursor to SU5402. The process for making 4a has also been optimized which involves a non-chr ...
Summary of Facts and Submissions. I. This appeal lies from the decision of the Examining Division to refuse the European application No. 99. 941 923.7 (publication No. 1 098 876) on the ground that the claims according to the then pending request did not comply with the requirements of Articles 84 and 56 EPC.. II. The request refused by the Examining Division was the set of ten claims as originally filed. Independent Claim 1 and dependent Claims 6, 8 and 9 read as follows:. 1. A process for the cyclisation of 4-amino-2- halobutyric acid to azetidine-2-carboxylic acid wherein more than 20 g of 4-amino-2-halobutyric acid is cyclised per litre of reaction mixture.. 6. A process as claimed in any of claims 1 to 5, characterized in that the 4-amino-2-halobutyric acid is added as its hydrohalide salt to hot aqueous base.. 8. A process as claimed in claim 6 or claim 7, characterised in that the base is at a temperature of more than 80°C.. 9. A process as claimed in any one of claims 6 to 8, ...
Structure, properties, spectra, suppliers and links for: 4-[4-Oxo-3-(phenylsulfanyl)-3,4-dihydro-1H,2H-spiro[azetidine-2,1-naphthalen]-1-yl]benzaldeh.
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Novo Nordisk is developing somapacitan, a long-acting human growth hormone derivative (also known as NN 8640 or NNC 0195 0092) for the treatment of growth
Just when you thought The Martialist (Phil Elmore s online publication) was dead and gone, he publishes the mega issue which really means he missed 5 or so issues and chucked them all together. One of the few good things to come out of this literary classic is that it includes my article, written to test whether he verifies the effectiveness and veracity of the self-protection advice he prints. The homemade anti-knife vest Starts page 13:
Just when you thought The Martialist (Phil Elmore s online publication) was dead and gone, he publishes the mega issue which really means he missed 5 or so issues and chucked them all together. One of the few good things to come out of this literary classic is that it includes my article, written to test whether he verifies the effectiveness and veracity of the self-protection advice he prints. The homemade anti-knife vest Starts page 13:
The mixture of the above crude nitrile VI (43 g) was treated with 150 ml of concentrated HCl (37%) (150 mL) and refluxed overnight to give the crude acid VII*. The hydrochloric acid excess was removed by rotatory evaporator and the residue was evaporated with water (100 mL) to remove HCl. The residue was then dissolved in 150 ml of water and added with 100 ml of acetone, then treated with 33 ml of a 6.25M NaOH solution to adjust pH to 5. A further amount of acetone (500 mL) was then added to the solution which was left to stand overnight at 4°C. The precipitated solid was subsequently filtered and the solid cake was washed with acetone and dried under vacuum to give crude acid VII (6.5 g) containing an about 3:1 mixture of 2(R),3(S) and 2(S),3(S) derivatives of compound VI ...
Verapamil is a common calcium blocker sold under different names used to treat heart conditions as well as blood pressure and other conditions.
No, I dont want to learn to shoot because I could accidentally shoot the wrong person; No, I dont want to skydive because Id crap my pants and embarrass myself, then my parachute wouldnt open (which would make the crapping of my pants completely invisible); I really dont want to scuba dive because Im afraid my breathing apparatus will fail and Ill drown; I dont need to go through the process of getting a license to carry my gun on me because if I actually carry my gun I will most likely get mugged and the robber will take it from me and use it on me; No, Hubby you dont need to make that eight-hour drive to a tactical class youve always wanted to take by yourself because you could fall asleep behind the wheel and crash... ...
Class I lantibiotic bacteriocin Gallidermin precursor (has a mersacidin-like Lipid II domain, and forms Lipid II-dependent pores) (Sahl and Bierbaum, 1998). The genetic organization, biosynthesis, modification, excretion, extracellular activation of the modified pre-peptide by proteolytic processing, self-protection of the producer, gene regulation, structure, and mode of action have been reviewed (Götz et al. 2014 ...
TY - JOUR. T1 - Olfactory bulbectomy induced oxidative and cell damage in rat. T2 - Protective effect of melatonin. AU - Tasset, Inmaculada. AU - Medina, F. J.. AU - Peña, J.. AU - Jimena, I.. AU - muñoz, M. del Carmen. AU - Salcedo, M.. AU - Ruiz, C.. AU - Feijóo, M.. AU - Montilla, P.. AU - Túnez, I.. PY - 2010. Y1 - 2010. N2 - In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action ...
Volatile Glycosylation in Tea Plants: Sequential Glycosylations for the Biosynthesis of Aroma β-Primeverosides Are Catalyzed by Two Camellia sinensis GlycosyltransferasesVolatile Glycosylation in Tea Plants: Sequential Glycosylations for the Biosynthesis of Aroma β-Primeverosides Are Catalyzed by Two Camellia sinensis GlycosyltransferasesAA12046875 ...
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Abstract: Gaining access to stereodefined deoxy-sugar containing oligosaccharides, such as those containing 2,6-dideoxy and 2,3,6-trideoxy motifs, remains a formidable challenge. This is largely due to the difficulties associated with controlling the selectivity of glycosylations using deoxy-sugar donors. Herein, the development of three generations of reagent-controlled approaches utilizing cyclo... read morepropenium cations are described. Chapter 2 describes our first-generation approach which utilized a 3,3-dichloro-1,2-diphenylcyclopropene/tetrabutylammonium iodide (TBAI) promoter system for α-selective glycosylations. These substrates reacted with a range of glycosyl acceptors to afford products in 55 to 99% yield, with selectivities ranging from 3:1 α:β to all α, determined by NMR. In chapter 3 we describe how we improved upon the method by utilizing a 3,3-dibromo-1,2-diphenylcyclopropenone/TBAI system. This latter system activated deoxy-sugar donors to react with a range of glycosyl ...
Only 13% of gun owners state that their guns are for self-protection only ... Nearly as many people die by guns as by auto accidents (deaths by auto accidents ... Slideshow 2815 by adamdaniel
When I gave my State of the Kernel Self-Protection Project presentation at the 2016 Linux Security Summit, I included some slides covering some quick bullet points on things I found of interest in recent Linux kernel releases. Since there wasnt a lot of time to talk about them all, I figured Id make some short blog posts here about the stuff I was paying attention to, along with links to more information. This certainly isnt everything security-related or generally of interest, but theyre the things I thought needed to be pointed out. If theres something security-related you think I should cover from v4.3, please mention it in the comments. Im sure I havent caught everything. :). A note on timing and context: the momentum for starting the Kernel Self Protection Project got rolling well before it was officially announced on November 5th last year. To that end, I included stuff from v4.3 (which was developed in the months leading up to November) under the umbrella of the project, since the ...
The restorer is specially designed for sensitive and damaged scalp to soothe scalp symptoms caused by sensitivity, hair dye, or season changing. It effectively enhances your scalp self-protection system to a healthy state.
hehehhe so Ive been doing some research on pheromones and cant quite find enough solid info on safety with regards to hormonal balance... please correct me if Im wrong but it seems that pheromones are hormone derivatives mostly (meaning they are the byproducts of hormones that have broken down) a...
Successfully completed his master degree in 2011 entitled "New studies of Glycosylations with Complex Oxianion Saccharide-Derivatives". A mechanistic illustration is shown in Scheme 1, illustrating the differences between conventional glycosylations using protecting group chemistry and by using a base promoted approach, which potentially allows for a reactivity based regioselective glycosylation. [1-2 ...
What is CombatiX™?. CombatiX™ is unlike any other combatives system out there! CombatiX™ is not simply Martial Arts. Instead, it is a highly specialized self-protection system developed extensively over decades of practical combative experience. We have evaluated and refined the techniques taught it many special forces and law enforcement programs to create an easy-to-learn and highly effective system of defensive tactics.. We have incorporated extensive knowledge of anatomy and physiology into CombatiX™. Most existing programs are based on Martial Arts systems which incorporate a block/punch/kick mentality to fighting. In those systems, brute force is favored. Unfortunately, this means that one has to have superior strength and size to be effective. With CombatiX™, training is focused on attacking the weaknesses of the human body.. For those who need or want to incorporate weapons, there is no need to learn a different system with highly specialized stances and techniques. With ...
I work in the pharmaceutical industry as a scientist and thus am very familiar with genetic engineering. We use it to engineer cell lines to produce the protein biologicals we engineer as medicines, such as antibodies. It is a common and well known concept that the species that one produces those proteins in matters very much, ie, if you take a single gene and express it in various species of cell lines, you will not get the same final protein due to something called post translational modifications. For example, the protein may have parts of it cut off, it may be folded differently, different phosphorylations may occur, or glycosylations (sugars) will get added on in different patterns. Sometimes those differences have little effect, and sometimes those effects are quite huge - you just dont know until you test it. This is what a lot of geneticists fail to convey when talking about genetic engineering. Sure, when you move DNA from species to another, that DNA is all made of the same ...
DOI: http://dx.doi.org/10.1016/j.dhjo.2016.12.014. Background. The prevalence of any child sexual abuse (CSA) experience before the age of 16 years ranges from 10.2 to 35.2% in China,1-5 but there has been no research so far exploring the level of awareness of CSA prevention and self-protection skills among Chinese children with hearing loss.. Objective. The school based survey examines the CSA prevention knowledge and self-protection skills in Chinese children with hearing loss.. Methods. Fifty-one students (30 boys, 21 girls) from 10 to 16 years old participated in the study. Childrens CSA prevention knowledge and self-protection skills were tested by using anonymous self-administered questionnaire which was mainly designed based on previous Chinese CSA research questionnaires, the Personal Safety Questionnaire, and the What If Situations Test (WIST). Results. There were ten questions assessing the knowledge of CSA but none of the children could correctly answer all and seventy percent of ...
On Thursday, December 28th, 2017, researchers at Nanyang Technological University in Singapore announced theyd developed a skin path that delivers anti-obesity drugs to the body with a lower risk of side effect than that associated with the same drugs (including a thyroid hormone derivative) when they are administered via injection or swallowed in a pill.. However, there are similarities with an injection because the ingredients are housed in hundreds of micro-needles that embed in the skin when the slimming patch is applied and the degrade in a manner that feeds the white adipose tissue below the skin a drug that causes it to turn brown.. Researchers at Columbia University Medical Center in New York are working on something similar. The needles deliver nanoparticles that change the fat near the patch application area and, when details of the project hit the news in September 2017, it sparked a lot of interest.. Both micro-needle patches have been tested on mice. The researchers in Singapore ...
This time last year, the region was abuzz with early findings of diseased mosquitoes carrying Eastern equine encephalitis, or EEE. This year, as of Friday, no mosquitoes have tested positive for the virus. Still, local and state health officials are urging people to get in the habit now of self-protection.
Animals respond to threats in many complex ways. Rats, for instance, try to escape when threatened, but will fight when cornered. Some animals stand perfectly still so that predators will not see them. Many animals freeze or play dead when touched in the hope that the predator will lose interest.. Other animals have alternative self-protection methods. Some species of cold-blooded animals change color swiftly, to camouflage themselves.[29] These responses are triggered by the sympathetic nervous system, but, in order to fit the model of fight or flight, the idea of flight must be broadened to include escaping capture either in a physical or sensory way. Thus, flight can be disappearing to another location or just disappearing in place. And often both fight and flight are combined in a given situation.. The fight or flight actions also have polarity - the individual can either fight or flee against something that is threatening, such as a hungry lion, or fight for or fly towards something that is ...
BAE Systems, Information and Electronic Systems Integration Incorporated, Nashua, New Hampshire, is being awarded a potential $41 million contract for four high-frequency wideband AN/SQQ-32(v)4 systems and associated engineering services and support that will detect and classify bottom and moored sea mines. The AN/SQQ-32(v)4 will be deployed from carriers for self-protection. High-frequency wideband AN/SQQ-32(v)4 will replace the in-service AN/SQQ-32(v)3 detection sonar and will improve detection performance and target resolution in high clutter environments including littoral zones and confined straits. ...
Looking for SPECTRUM Aminopyrazine Carboxylic Acid,25g (26WR20)? Graingers got your back. Price:$85.50. Easy ordering & convenient delivery. Log-in or register for your pricing.
Animals, Area Under Curve, Blood Glucose/metabolism, Cardiovascular System, Ischemia, Lactic Acid/*chemistry, Microdialysis, Myocardial Infarction/pathology, Myocardium/metabolism/*pathology, Peptide Fragments/*chemistry/pharmacology, Protein Precursors/chemistry, Pyruvic Acid/*chemistry, Reperfusion Injury, Research Support; Non-U.S. Govt, Swine, Time Factors ...
When it comes to self-protection this means we need to understand criminal behaviour ("the enemy") and the person aiming to keep themselves safe (the "yourself"). Most martial artists insert themselves into both roles and hence entirely mess self-protection up.. The criminal will not act like a fellow martial artist. The have different motivations and goals. Its true that two martial artists in a consensual exchange will not "grab the others wrist and stand there", but that will happen when the criminal wishes to control and assert dominance.. We also should not assume the person trying to mitigate criminal action is, likewise, a fellow martial artist. Again, a very common error i.e. "just keep punching them until they are unconscious" or "heres a very advanced lock".. The self-protection student wants to avoid criminal harm. They will not have trained for decades as most of us have. Martial artists like martial arts - for all kinds of reasons - and hence they devote large parts of their ...
When it comes to self-protection this means we need to understand criminal behaviour ("the enemy") and the person aiming to keep themselves safe (the "yourself"). Most martial artists insert themselves into both roles and hence entirely mess self-protection up.. The criminal will not act like a fellow martial artist. The have different motivations and goals. Its true that two martial artists in a consensual exchange will not "grab the others wrist and stand there", but that will happen when the criminal wishes to control and assert dominance.. We also should not assume the person trying to mitigate criminal action is, likewise, a fellow martial artist. Again, a very common error i.e. "just keep punching them until they are unconscious" or "heres a very advanced lock".. The self-protection student wants to avoid criminal harm. They will not have trained for decades as most of us have. Martial artists like martial arts - for all kinds of reasons - and hence they devote large parts of their ...
Ive come up with a couple of responses to the do you have any children question, depending on the situation. Usually I default to, No, we arent able to have children, delivered without any smile. Then Im prepared for the follow-up solutions of just relax and have you thought of adoption with my reproductive endocrinologist tells me relaxing doesnt work when it comes to infertility and every infertile person thinks about adoption, but it isnt fair to adopted children to be acquired as a conception aid. I live in the Bible Belt, so whenever an elderly woman asks me how many children I have (they all just assume that since Im a woman ergo I must have kids), I almost always respond with, God decided hed keep all my children with him in heaven instead of giving them to me. I usually get blinks in reply and then a quick change of subject. People, Ive discovered, find it very easy to deliver the its all in Gods plan for you line, but theyre not used to hearing someone give it ...
Polyribosomes containing nascent [3H]proline-labeled collagen chains were isolated from chick embryo fibroblasts in culture. These nascent chains were nearly completely hydroxylated, as indicated by the presence of [3H]hydroxyproline and high hydroxyproline/proline ratios. The polyribosomes were suspended in D2O at 15 degrees and the infrared spectrum was determined using a reference cell containing collagen-depleted polyribosomes in D2O, matched to equal RNA content. The amide I and amide II bands were observed. When the polyribosomes were heated in D2O at 44 degrees in the infrared cells, the N--D amide II absorbance at 1480 cm-1 increased markedly, indicating that H leads to D exchange had occurred. Collagen-depleted polyribosomes showed no such changes in absorbance at 1450-1480 cm-1 upon heating. Polyribosomes recovered from the infrared cells after treatment at 44 degrees and cooling still contained collagen, as indicated by their [3H]hydroxyproline content. These data indicate that ...
return to top]. calcium channel blocker (or calcium blocker) - a medication that lowers blood pressure and slows heart rate.. capillaries - tiny blood vessels between arteries and veins that distribute oxygen-rich blood to the body.. cardiac - pertaining to the heart.. cardiac arrest - the stopping of heartbeat.. cardiac catheterization - a diagnostic procedure in which a tiny, hollow tube (catheter) is advanced from a vessel in the groin through the aorta into the heart in order to image the heart and blood vessels.. cardiac output - the amount of blood that goes through the circulatory system in one minute.. cardiology - the clinical study and practice of treating the heart.. cardiomyopathy - a disease of the heart muscle that causes it to lose its pumping strength.. cardiovascular (CV) - pertaining to the heart and blood vessel (circulatory) system.. cardioversion - the procedure of applying electrical shock to the chest to change an abnormal heartbeat into a normal one.. carotid artery - the ...
return to top]. calcium channel blocker (or calcium blocker) - a medication that lowers blood pressure and slows heart rate.. capillaries - tiny blood vessels between arteries and veins that distribute oxygen-rich blood to the body.. cardiac - pertaining to the heart.. cardiac arrest - the stopping of heartbeat.. cardiac catheterization - a diagnostic procedure in which a tiny, hollow tube (catheter) is advanced from a vessel in the groin through the aorta into the heart in order to image the heart and blood vessels.. cardiac output - the amount of blood that goes through the circulatory system in one minute.. cardiology - the clinical study and practice of treating the heart.. cardiomyopathy - a disease of the heart muscle that causes it to lose its pumping strength.. cardiovascular (CV) - pertaining to the heart and blood vessel (circulatory) system.. cardioversion - the procedure of applying electrical shock to the chest to change an abnormal heartbeat into a normal one.. carotid artery - the ...
To the editor: In the last 2 years I have seen two patients with the severe pain of ureteral colic. Usually, such patients are given a narcotic, and fluids are forced until the stone, if it is not excessively large, is spontaneously excreted (1). However, the patient may have much pain.. It is reasonable to anticipate that a calcium blocker, such as nifedipine, a drug accepted by the Food and Drug Administration that dilates spastic coronary arteries, (2) might have a similar effect on spastic ureters, which have a histologic structure like that of the arteries-an internal epithelial cell lining, ...
Taking a pregnancy test, and getting a positive result, only to find out it was false is truly a disappointing surprise. Fertility drugs that contain B-HCG have the greatest risk in producing false positives. A false positive reading is one where the test is positive but the actual outcome is negative. The false positive is due to the presence of beta Human Gonadotropin( B-HCG) hormone derivatives found in some fertility medications.
Indeed, liberal have long engaged in nasty lies about ordinary Americans who engage in no violent talk and obey the laws, but also believe in their right to own guns for self-protection. Heres merely the most recent such lies.. http://www.nationalreview.com/corner/435847/katie-couric-lying-anti-gun-documentary. Imagine a different context, one in which Muslims are asked about violence in their religion-yes, actually aggressively asked with examples of that violence given. That is a stretch isnt it? Further imagine that those Muslims give carefully thought out, cogent answers. Finally, imagine Katie Couric and her documentary team cutting out those answers and substituting, as she did with these gun rights advocates, a video of those Muslims looking around waiting for the interview to begin-implying that they had no answers.. Yes, in both cases that video substitution is a nasty, vicious lie. But when it comes to gun rights advocates, the editing is done to make them look bad. An NRA member is ...
Now that we have covered the basics of systemic enzyme therapy and gone over safety issues, its time to delve into the actual benefits of taking systemic enzyme supplements. Today, we will be focusing on what we perceive to be (and on what most people perceive to be) the #1 benefit of systemic enzyme therapy - namely, to fight inflammation.. Before doing this, however, its important to have a basic understanding of what inflammation is. According to Medical News Today, inflammation is "the bodys attempt at self-protection to remove harmful stimuli". In other words, inflammation kick-starts your bodys healing process. For a wound to heal, it first has to swell up and turn red.. However, it is good to note that inflammation is NOT always a helpful response to your body. What TIME magazine has recently labelled as "The Secret Killer" is currently believed to be an underlying cause of many diseases such as cancer, allergies and even depression. But while chronic inflammation has just recently ...
Macrophages are attracted to developing tumors and can participate in immune surveillance to eliminate neoplastic cells. In response, neoplastic cells utilize NF-κB to suppress this killing activity, but the mechanisms underlying their self-protection remain unclear. Here, we report that this dynamic interaction between tumor cells and macrophages is integrally linked by a soluble factor identified as growth and differentiation factor 15 (GDF-15). In vitro, tumor-derived GDF-15 signals in macrophages to suppress their proapoptotic activity by inhibiting TNF and nitric oxide (NO) production. In vivo, depletion of GDF-15 in Ras-driven tumor xenografts and in an orthotopic model of pancreatic cancer delayed tumor development. This delay correlated with increased infiltrating antitumor macrophages. Further, production of GDF-15 is directly regulated by NF-κB, and the colocalization of activated NF-κB and GDF-15 in epithelial ducts of human pancreatic adenocarcinoma supports the importance of this ...
Macrophages are attracted to developing tumors and can participate in immune surveillance to eliminate neoplastic cells. In response, neoplastic cells utilize NF-κB to suppress this killing activity, but the mechanisms underlying their self-protection remain unclear. Here, we report that this dynamic interaction between tumor cells and macrophages is integrally linked by a soluble factor identified as growth and differentiation factor 15 (GDF-15). In vitro, tumor-derived GDF-15 signals in macrophages to suppress their proapoptotic activity by inhibiting TNF and nitric oxide (NO) production. In vivo, depletion of GDF-15 in Ras-driven tumor xenografts and in an orthotopic model of pancreatic cancer delayed tumor development. This delay correlated with increased infiltrating antitumor macrophages. Further, production of GDF-15 is directly regulated by NF-κB, and the colocalization of activated NF-κB and GDF-15 in epithelial ducts of human pancreatic adenocarcinoma supports the importance of this ...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
1-BOC-PIPERAZINE-2-CARBOXYLIC ACID(CAS:159532-59-9),supplier of 1-BOC-PIPERAZINE-2-CARBOXYLIC ACID(CAS:159532-59-9) ,inquiry for 1-BOC-PIPERAZINE-2-CARBOXYLIC ACID(CAS:159532-59-9)
You are viewing an interactive 3D depiction of the molecule 2-amino-4-hydroxypteridine-6-carboxylic acid (C7H5N5O3) from the PQR.

KAKEN - Research Projects | Creation of Innovative Organocatalysts Using the Network of Intermolecular Interactions (KAKENHI...KAKEN - Research Projects | Creation of Innovative Organocatalysts Using the Network of Intermolecular Interactions (KAKENHI...

Journal Article] Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β- ...
more infohttps://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23105007/

No questions in Glycopyrrolate - lookformedical.comNo questions in Glycopyrrolate - lookformedical.com

A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
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I have a test and soon! - lookformedical.comI have a test and soon! - lookformedical.com

I have to take a test and I use chewing tobacco & smoke the last time I smoked was yesterday at ... Is there any hope that I will pass this test?
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Alfred Hassner - WikipediaAlfred Hassner - Wikipedia

Hassners group pioneered in methodology for synthesis of small ring heterocycles such as aziridines, azirines, azetines, as ...
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Items where Author is Hemming, Karl - University of Huddersfield RepositoryItems where Author is Hemming, Karl - University of Huddersfield Repository

1-azetines as thiocyanate equivalents. Tetrahedron, 69 (4). pp. 1279-1284. ISSN 0040-4020 ... 1-azetines as thiocyanate equivalents. Tetrahedron, 69 (4). pp. 1279-1284. ISSN 0040-4020 ... 1-azetines as thiocyanate equivalents. Tetrahedron, 69 (4). pp. 1279-1284. ISSN 0040-4020 ... 1-azetines as thiocyanate equivalents. Tetrahedron, 69 (4). pp. 1279-1284. ISSN 0040-4020 ...
more infohttp://eprints.hud.ac.uk/view/authors_id/855.keywords.html

Items where School is School of Applied Sciences | Biomolecular Sciences Research Centre - University of Huddersfield...Items where School is "School of Applied Sciences | Biomolecular Sciences Research Centre" - University of Huddersfield...

... nonenes by the addition of a cyclopropenone to 4-vinyl substituted 1-azetines-isomers of the homotropane nucleus. Tetrahedron ...
more infohttp://eprints.hud.ac.uk/view/depts/bmsrc.default.html

SupervisorsSupervisors

... especially azetidines and azetines); direct generation of enantioenriched α-alkyl-substituted aldehydes; catalytic ...
more infohttp://www.oxfordsynthesiscdt.ox.ac.uk/people/supervisors.html

新闻详细--上海交大化学化工学院新闻详细--上海交大化学化工学院

Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β- ...
more infohttp://scce.sjtu.edu.cn/news.php?aid=1752

Ximelagatran - DrugBankXimelagatran - DrugBank

Azetines. *Benzene Derivatives. *Benzyl Compounds. *Blood and Blood Forming Organs. *Cytochrome P-450 CYP2C9 Substrates ...
more infohttps://www.drugbank.ca/drugs/DB04898

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

The torquoselectivity of the 4π electrocyclic ring-opening reaction of 2-azetines can be controlled by the Brønsted acidity of ... Full Text Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β- ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=Author:Kitaura,%20Kazuo

Pyrimidines | Colorado PROFILESPyrimidines | Colorado PROFILES

Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, Nathenson M, Doebele RC, Farago AF, Pappo AS, Turpin B, Dowlati A, Brose MS, Mascarenhas L, Federman N, Berlin J, El-Deiry WS, Baik C, Deeken J, Boni V, Nagasubramanian R, Taylor M, Rudzinski ER, Meric-Bernstam F, Sohal DPS, Ma PC, Raez LE, Hechtman JF, Benayed R, Ladanyi M, Tuch BB, Ebata K, Cruickshank S, Ku NC, Cox MC, Hawkins DS, Hong DS, Hyman DM. Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children. N Engl J Med. 2018 02 22; 378(8):731-739 ...
more infohttps://profiles.ucdenver.edu/display/215598

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1,2,4-Oxadiazoles from cycloreversions of oxadiazabicyclo[3.2.0]heptenes: 1-Azetines as thiocyanate equivalents. Hemming, K., ... 1,3-dipolar cycloadditions of 2-Ethoxy- and 2-(ethylthio)-1-azetines with nitrile oxides, nitrile ylides and nitrilimines: An ...
more infohttps://pure.hud.ac.uk/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=&format=&ordering=type&descending=false

HeteroCyclesHeteroCycles

... isoquinolines along with 1-azetines. The preferential formation of 2 to 3 was explained in terms of steric effects on the ...
more infohttps://heterocycles.jp/newlibrary/libraries/journal/60/3

Azepines | Harvard Catalyst Profiles | Harvard CatalystAzepines | Harvard Catalyst Profiles | Harvard Catalyst

Bandopadhayay P, Piccioni F, ORourke R, Ho P, Gonzalez EM, Buchan G, Qian K, Gionet G, Girard E, Coxon M, Rees MG, Brenan L, Dubois F, Shapira O, Greenwald NF, Pages M, Balboni Iniguez A, Paolella BR, Meng A, Sinai C, Roti G, Dharia NV, Creech A, Tanenbaum B, Khadka P, Tracy A, Tiv HL, Hong AL, Coy S, Rashid R, Lin JR, Cowley GS, Lam FC, Goodale A, Lee Y, Schoolcraft K, Vazquez F, Hahn WC, Tsherniak A, Bradner JE, Yaffe MB, Milde T, Pfister SM, Qi J, Schenone M, Carr SA, Ligon KL, Kieran MW, Santagata S, Olson JM, Gokhale PC, Jaffe JD, Root DE, Stegmaier K, Johannessen CM, Beroukhim R. Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nat Commun. 2019 06 03; 10(1):2400 ...
more infohttps://connects.catalyst.harvard.edu/Profiles/display/Concept/Azepines

Azocines | Profiles RNSAzocines | Profiles RNS

This graph shows the total number of publications written about "Azocines" by people in this website by year, and whether "Azocines" was a major or minor topic of these publications ...
more infohttps://profiles.rush.edu/display/10978

Oxepins | Profiles RNSOxepins | Profiles RNS

Compounds based on a 7-membered heterocyclic ring including an oxygen. They can be considered a medium ring ether. A natural source is the MONTANOA plant genus. Some dibenzo-dioxepins, called depsidones, are found in GARCINIA plants ...
more infohttps://profiles.rush.edu/display/2719

Nature CommsNature Comms

Functionalization of nucleophiles with chiral azetines Contributor Nature Comms Behind the paper ...
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Academic BibliographyAcademic Bibliography

Experimental and computational study of the conrotatory ring opening of various 3-chloro-2-azetines Sven Mangelinckx UGent, ...
more infohttps://biblio.ugent.be/publication?start=500&limit=250&q=affiliation+exact+LA11+and+classification+exact+A1&sort=datecreated.desc&embed=1

A1 publications | Center for Molecular ModelingA1 publications | Center for Molecular Modeling

Experimental and Computational Study of the Conrotatory Ring Opening of Various 3-Chloro-2-azetines , S. Mangelinckx, V. Van ...
more infohttps://molmod.ugent.be/a1_publications

Index Catalog // Emory Electronic Theses and DissertationsIndex Catalog // Emory Electronic Theses and Dissertations

Part 1: Stereoselective Synthesis of Quaternary Center Bearing Azetines and β-Amino Ac... ...
more infohttps://etd.library.emory.edu/catalog?f%5Bdepartment_sim%5D%5B%5D=Chemistry&