AnatomyOrganismsDiseasesChemicals and DrugsDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaNamed GroupsHealth CareGeographicals
AzetinesResearchEgyptResearch PersonnelResearch Support as TopicSchistosomiasisBiomedical ResearchMolluscacidesCitrobacter freundiiCardiac MyosinsSarcomeresCarrier ProteinsCardiomyopathy, HypertrophicChemistry, AnalyticMyosinsDisopyramideSpiramycinAnti-Arrhythmia AgentsPrenylamineAnesthetics, LocalLidocaineAnestheticsSupreme Court DecisionsCimicidaeCivil RightsHistiocytosis, SinusPiperazinesAfrica, SouthernWilliams SyndromeHemagglutinins, ViralInfluenza A virusInfluenza, HumanHemagglutinin Glycoproteins, Influenza VirusHemagglutininsInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 Subtype
AzetinesResearch: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Egypt: A country in northern Africa, bordering the Mediterranean Sea, between Libya and the Gaza Strip, and the Red Sea north of Sudan, and includes the Asian Sinai Peninsula Its capital is Cairo.Research Personnel: Those individuals engaged in research.Research Support as Topic: Financial support of research activities.Schistosomiasis: Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Molluscacides: Agents destructive to snails and other mollusks.Citrobacter freundii: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria found in humans and other animals including MAMMALS; BIRDS; REPTILES; and AMPHIBIANS. It has also been isolated from SOIL and WATER as well as from clinical specimens such as URINE; THROAT; SPUTUM; BLOOD; and wound swabs as an opportunistic pathogen.Cardiac Myosins: Myosin type II isoforms found in cardiac muscle.Sarcomeres: The repeating contractile units of the MYOFIBRIL, delimited by Z bands along its length.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Cardiomyopathy, Hypertrophic: A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).Chemistry, Analytic: The branch of chemistry dealing with detection (qualitative) and determination (quantitative) of substances. (Grant & Hackh's Chemical Dictionary, 5th ed)Myosins: A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.Spiramycin: A macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii.Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Prenylamine: A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.Anesthetics: Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.Supreme Court Decisions: Decisions made by the United States Supreme Court.Cimicidae: A family of wingless, blood-sucking insects of the suborder HETEROPTERA, including the bedbugs and related forms. Cimex (BEDBUGS), Heamatosiphon, and Oeciacus are medically important genera. (From Dorland, 28th ed)Civil Rights: Legal guarantee protecting the individual from attack on personal liberties, right to fair trial, right to vote, and freedom from discrimination on the basis of race, color, religion, sex, age, disability, or national origin. (from http://www.usccr.gov/ accessed 1/31/2003)Histiocytosis, Sinus: Benign, non-Langerhans-cell, histiocytic proliferative disorder that primarily affects the lymph nodes. It is often referred to as sinus histiocytosis with massive lymphadenopathy.PiperazinesAfrica, Southern: The geographical area of Africa comprising ANGOLA; BOTSWANA; LESOTHO; MALAWI; MOZAMBIQUE; NAMIBIA; SOUTH AFRICA; SWAZILAND; ZAMBIA; and ZIMBABWE.Williams Syndrome: A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.Hemagglutinins, Viral: Specific hemagglutinin subtypes encoded by VIRUSES.Influenza A virus: The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.Influenza, Human: An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.Hemagglutinin Glycoproteins, Influenza Virus: Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.Hemagglutinins: Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.Influenza A Virus, H1N1 Subtype: A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.Influenza A Virus, H3N2 Subtype: A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 3 and neuraminidase 2. The H3N2 subtype was responsible for the Hong Kong flu pandemic of 1968.

Effect of L-azetidine-2-carboxylic acid on glycosylations of collagen in chick-embryo tendon cells. (1/17)

The glycosylations of hydroxylysine during collagen biosynthesis in isolated chick-embryo tendon cells were studied by using pulse-chase labelling experiments with [14C]-lysine. The hydroxylation of lysine and the glycosylations of hydroxylysine continued after a 5 min pulse label for up to about 10 min during the chase period. These data differ from those obtained previously in isolated chick-embryo cartilage cells, in which, after a similar 5 min pulse label, these reactions continued during the chase period for up to about 20 min. The collagen synthesized by the isolated chick-embryo tendon cells differed markedly from the type I collagen of adult tissues in its degree of hydroxylation of lysine residues and glycosylations of hydroxylysine residues. When the isolated tendon cells were incubated in the presence of L-azetidine-2-carboxylic acid, the degree of glycosylations of hydroxylysine during the first 10 min of the chase period was identical with that in cells incubated without thcarboxylic acid for at least 60 min, whereas no additional glycosylations took place in the control cells after the 10 min time-point. As a consequence, the collagen synthesized in the presence of this compound contained more carbohydrate than did the collagen synthesized by the control cells. Additional experiments indicated that azetidine-2-carboxylic acid did not increase the collagen glycosyltransferase activities in the tendon cells or the rate of glycosylation reactions when added directly to the enzyme incubation mixture. Control experiments with colchicine indicated that the delay in the rate of collagen secretion, which was observed in the presence of azetidine-2-carboxylic acid, did not in itself affect the degree of glycosylations of collagen. The results thus suggest that the increased glycosylations were due to inhibition of the collagen triple-helix formation, which is known to occur in the presence of azetidine-2-carboxylic acid.  (+info)

Incorporation of L-azetidine-2-carboxylic acid into hemoglobin in rabbit reticulocytes in vitro. (2/17)

L-Azetidine-2-carboxylic acid is the naturally occurring lower homologue of L-proline. Reticulocytes from anemic rabbits incubated with DL-[14-C]azetidine-2-carboxylic acid synthesized radiolabeled hemoglobin, which when isolated from cell lysates co-chromatographed with unlabeled hemoglobin on Sephadex G-100 columns. Amino acid analysis of hemoglobin from reticulocytes incubated with DL-[14-C]-azetidine-2-carboxylic acid suggested that the homologue was incorporated into hemoglobin intact and unaltered. Alternatively, another amino acid analogue, 1-aminocyclopentane-[1-14-C]carboxylic acid, which is purported to be a valine antagonist, was not incorporated into hemoglobin under these conditions. Incubation of reticulocytes with 1, 5, and 10 mM L-azetidine-2-carboxylic acid reduced L-[U-14-C]proline (0.10 mM) incorporation into hemoglobin by 25, 58, and 72%, respectively. Conversely, 1.45 and 145 muM L-proline reduced radiolabeled azetidine-2-carboxylic acid (0.8 mM) in corporation into hemoglobin by 45 and 92%, respectively. Incorporation of L-[U-14-C]leucine and L-[U-14-C]lysine (0.1 mM each) into hemoglobin was unaffected at these concentrations of L-azetidine-2-carboxylic acid. These results suggest that L-azetidine-2-carboxylic acid is incorporated into hemoglobin without reducing the rate of globin synthesis in rabbit reticulocytes in vitro. The alpha and beta chains of hemoglobin into which [14-C]azetidine-2-carboxylic acid had been incorporated in rabbit reticulocytes in vitro were resolved electrophoretically on sodium dodecyl sulfate-polyacrylamide gels. The ratio of total radioactivity in the alpha and beta chains separately extracted from gels was in good agreement with the known 7:4 ratio of prolyl residues in the respective chains. Autoradiograms of two-dimensional tryptic peptide maps of rabbit globin into which either [14-C]azetidine-2-carboxylic acid or [14-C]proline had been incorporated showed nearly identical patterns of radioactivity. These results suggest that azetidine-2-carboxylic acid substitutes specifically for prolyl residues during in vitro hemoglobin synthesis in rabbit reticulocytes.  (+info)

18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons. (3/17)

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Antihypertensive effect of CS-905, a novel dihydropyridine calcium blocker, in conscious hypertensive dogs. (4/17)

CS-905, (+-)-3-(1-diphenylmethylazetidin-3-yl)5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridine-dicarboxy lat e, is a novel dihydropyridine calcium blocker. Both CS-905 and nicardipine, when administered orally, produced a dose-dependent fall of blood pressure in conscious perinephritic hypertensive dogs. Unlike the hypotensive effect of nicardipine, that of CS-905 has a gradual onset and is long-lasting, with little increase in the heart rate and plasma renin activity (PRA). The lack of both tachycardia and increase of PRA is probably mostly due to the slow onset of antihypertensive action following CS-905.  (+info)

Generation and electrophile trapping of N-Boc-2-lithio-2-azetine: synthesis of 2-substituted 2-azetines. (5/17)

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Effects of a new thyrotropin-releasing hormone derivative on behavioral changes after focal cerebral ischemia in rats. (6/17)

We observed the effects of a new thyrotropin-releasing hormone derivative, YM-14673 (N alpha-[[(S)-4-oxo-2-azetidinyl]carbonyl]-L-histidyl-L-prolinamide dihydrate), on behavioral changes in rats for 3 weeks after focal cerebral ischemia. Under halothane anesthesia, the left middle cerebral artery was occluded via a transretro-orbital approach. YM-14673 was administered just after the operation and once a day for 3 weeks. Neurologic deficits, including hemiplegia and abnormal posture, and disturbance of passive avoidance learning were present in solvent-treated control rats for the entire 3 weeks. YM-14673 at 0.1 or 0.3 mg/kg i.p. or 1 mg/kg p.o. significantly accelerated the recovery of neurologic deficits and ameliorated cognitive disturbance compared with the solvent-treated controls although the drug at 0.1 and 0.3 mg/kg i.p. did not influence the size of the ischemic infarct. YM-14673 mitigated the behavioral disturbances in this model of chronic focal cerebral ischemia. We also discuss the suitability of this model for the evaluation of drugs.  (+info)

Beneficial renal effects of CS-905, a novel dihydropyridine calcium blocker, in SHR. (7/17)

CS-905 is a potent dihydropyridine calcium blocker that has a gradual and long-lasting antihypertensive action with little tachycardia in SHR. In this study, we investigated chronic and acute effects of CS-905 on renal functions in SHR. To examine the chronic effects, 23 week-old male SHR were treated with CS-905 (1 or 3 mg/kg/day, p.o.) or 0.3% CMC (carboxymethylcellulose). After the 15 week-treatment, the agent dose-relatedly lowered systolic blood pressure measured 24 hr after the final administration (184 +/- 2 and 173 +/- 3 mmHg at 1 and 3 mg/kg/day vs. 218 +/- 4 mmHg for the control group). Natriuresis and the reduction of urinary protein excretion were also observed in the CS-905 treated groups. Urinary NAG (N-acetyl-beta-D-glucosaminidase) activity tended to decrease, but not significantly. Histopathological changes observed in the SHR kidney were reduced by chronic treatment with CS-905. On a single oral administration in 38 week-old SHR, CS-905 caused natriuresis at a dose of 3 mg/kg, but did not affect urinary protein excretion and urinary NAG activity. These effects of CS-905 on renal functions may be beneficial in the treatment of hypertension.  (+info)

Interference with thyroid histogenesis by inhibitors of collagen synthesis. (8/17)

Histogenesis of thyroid follicles in the chick embryo begins with a penetration by cells of the mesenchymal capsule into a solid epithelial primordium. Before penetration occurs, slits containing fibrillar material form between the epithelial cells. The fibrillar material is an epithelial cell product as shown by its formation within channels that form in cultures of isolated epithelial primordia. The drugs L-azetidine-2-carboxylic acid (LACA) and alpha, alpha'-dipyridyl, which interfere with collagen synthesis, prevent the formation of fibrils in cultured epithelial primordia and in cultures of whole thyroids. Furthermore, mesenchymal cells do not invade when whole thyroid primordia are cultured in the presence of either drug. The effects of alpha, alpha'-dipyridyl are reversed by washing out the drug; the effects of LACA are reversed by incubation with equimolar or greater amounts of L-proline added to the medium along with the drug. The results are interpreted to mean that the fibrillar material is collagen of epithelial origin, that the collagen in some way plays a role in mesenchymal penetration of the epithelial primordium, and that the epithelium is responsible for the pattern of lobulation within the developing gland.  (+info)

2R,4S)-N-BOC-4-Hydroxypiperidine-2-carboxylic acid methyl ester, 95%, 98% ee, ACROS Organics™ 1g; Glass bottle (2R,4S)-N-BOC-4...2R,4S)-N-BOC-4-Hydroxypiperidine-2-carboxylic acid methyl ester, 95%, 98% ee, ACROS Organics™ 1g; Glass bottle (2R,4S)-N-BOC-4...
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Alfa Aesar™ N-Boc-3-iodo-L-alanine methyl ester, 98% 250mg Alfa Aesar™ N-Boc-3-iodo-L-alanine methyl ester, 98% | Fisher...Alfa Aesar™ N-Boc-3-iodo-L-alanine methyl ester, 98% 250mg Alfa Aesar™ N-Boc-3-iodo-L-alanine methyl ester, 98% | Fisher...
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Amlodipine. - Keyboard ExploitAmlodipine. - Keyboard Exploit
Amlodipine causes marked coronary and peripheral arterial vasodilation (which leads to plasma leakage in dependent areas since the veins remain constricted). As happens with other dihydropyridine calcium blockers, this results in a small percentage of patients having a problem with pedal edema (Am J Med. 2004;116:35-43). The pedal edema is not related to congestive heart failure and responds only inconsistently to diuretics, but it is not harmful.Mungkin akan nmpk sedikit gemuk sbb berlaku edema/bengkak.. ...
1S,2R,4S)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester - Alfa Chemistry1S,2R,4S)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester - Alfa Chemistry
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 321744-21-2((1S,2R,4S)-N-BOC-1-AMINO-2-HYDROXYCYCLOPENTANE-4-CARBOXYLIC ACID METHYL ESTER),please inquire us for 321744-21-2((1S,2R,4S)-N-BOC-1-AMINO-2-HYDROXYCYCLOPENTANE-4-CARBOXYLIC ACID METHYL ESTER).
R)-N-Boc-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine biochemical product blogR)-N-Boc-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine biochemical product blog
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N-Boc-(2S,3S)-3-Amino-2-hydroxy-3-(3-methyl-phenyl)-propanoic acid - Alfa ChemistryN-Boc-(2S,3S)-3-Amino-2-hydroxy-3-(3-methyl-phenyl)-propanoic acid - Alfa Chemistry
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CAS # 55447-00-2, (S)-N-Boc-1-Naphthylalanine, N-tert-Butoxycarbonyl-1-naphthyl-L-alanineCAS # 55447-00-2, (S)-N-Boc-1-Naphthylalanine, N-tert-Butoxycarbonyl-1-naphthyl-L-alanine
chemBlink provides information about CAS # 55447-00-2, (S)-N-Boc-1-Naphthylalanine, N-tert-Butoxycarbonyl-1-naphthyl-L-alanine, molecular formula: C18H21NO4.
N-Boc-2-piperidineacetic acid|149518-50-3|XinkaiN-Boc-2-piperidineacetic acid|149518-50-3|Xinkai
Founded in 2011, Suzhou Xinkai Bio-Medical Technology Co., Ltd. is located in Suzhou New District of Suzhou city in Jiangsu province. Xinkai focus is on the development of...
N-Boc-3-piperidineacetic acid|183483-09-2|XinkaiN-Boc-3-piperidineacetic acid|183483-09-2|Xinkai
Founded in 2011, Suzhou Xinkai Bio-Medical Technology Co., Ltd. is located in Suzhou New District of Suzhou city in Jiangsu province. Xinkai focus is on the development of...
Subject: regioselectivity / Publication Year: 2015 / Subject: chemical structure - PubAg Search ResultsSubject: 'regioselectivity' / Publication Year: 2015 / Subject: chemical structure - PubAg Search Results
ortho-Lithiation of N-Boc-3-bromopyrroles (7b, 7d) with LDA in THF at −75°C, followed by reactions with ethyl formate gave exclusive C2-formylpyrroles (9b, 9c, 9d, 9e) in good yields. This methodology was applied to the synthesis of 3-(2-formyl-4-methyl-1-H-pyrrol-3-yl)propanoic acid (4a), a penultimate precursor to SU5402. The process for making 4a has also been optimized which involves a non-chr ...
The new coronary vasodilators: calcium blockers<...The new coronary vasodilators: calcium blockers<...
TY - JOUR. T1 - The new coronary vasodilators. T2 - calcium blockers. AU - Hillis, L. D.. PY - 1980/1/1. Y1 - 1980/1/1. N2 - Considerable clinical promise is being shown by a group of investigational drugs that inhibit the movement of calcium into cells, thereby reducing both coronary and systemic vascular resistance and depressing myocardial contractility. In studies conducted here and abroad, calcium blockers appear to reduce the frequency of both typical and variant angina attacks and limit the extent and severity of myocardial injury in acute infarctions. Some of these agents also combat supraventricular tachyarrhythmias and reduce blood pressure in patients with systemic arterial hypertension.. AB - Considerable clinical promise is being shown by a group of investigational drugs that inhibit the movement of calcium into cells, thereby reducing both coronary and systemic vascular resistance and depressing myocardial contractility. In studies conducted here and abroad, calcium blockers appear ...
EPO - T 0573/03 (Azetidine-2-carboxylic acid/ASTRAZENECA) of 2.8.2005EPO - T 0573/03 (Azetidine-2-carboxylic acid/ASTRAZENECA) of 2.8.2005
Summary of Facts and Submissions. I. This appeal lies from the decision of the Examining Division to refuse the European application No. 99. 941 923.7 (publication No. 1 098 876) on the ground that the claims according to the then pending request did not comply with the requirements of Articles 84 and 56 EPC.. II. The request refused by the Examining Division was the set of ten claims as originally filed. Independent Claim 1 and dependent Claims 6, 8 and 9 read as follows:. 1. A process for the cyclisation of 4-amino-2- halobutyric acid to azetidine-2-carboxylic acid wherein more than 20 g of 4-amino-2-halobutyric acid is cyclised per litre of reaction mixture.. 6. A process as claimed in any of claims 1 to 5, characterized in that the 4-amino-2-halobutyric acid is added as its hydrohalide salt to hot aqueous base.. 8. A process as claimed in claim 6 or claim 7, characterised in that the base is at a temperature of more than 80°C.. 9. A process as claimed in any one of claims 6 to 8, ...
4-[4-Oxo-3-(phenylsulfanyl)-3,4-dihydro-1H,2H-spiro[azetidine-2,1-naphthalen]-1-yl]benzaldehyde | C25H21NO2S | ChemSpider4-[4-Oxo-3-(phenylsulfanyl)-3',4'-dihydro-1H,2'H-spiro[azetidine-2,1'-naphthalen]-1-yl]benzaldehyde | C25H21NO2S | ChemSpider
Structure, properties, spectra, suppliers and links for: 4-[4-Oxo-3-(phenylsulfanyl)-3,4-dihydro-1H,2H-spiro[azetidine-2,1-naphthalen]-1-yl]benzaldeh.
Cas Number Listed 1 Nicosulfuron, 1-N-Boc-3-hydroxyazetidine, 1-Piperidinecarboxylicacid, 3-hydroxy-, 1,1-dimethylethyl ester, ...Cas Number Listed 1 Nicosulfuron, 1-N-Boc-3-hydroxyazetidine, 1-Piperidinecarboxylicacid, 3-hydroxy-, 1,1-dimethylethyl ester, ...
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ESR3 - EV glycosylations as therapeutic and diagnostic targets of prostate cancer - proEVLifeCycleESR3 - EV glycosylations as therapeutic and diagnostic targets of prostate cancer - proEVLifeCycle
The project aims to develop simple and cost-efficient diagnostic assays for the detection and monitoring of PCa. Our on-going research efforts aim to utilize the detection of prostate specific targets and aberrant glycosylations on EVs as a novel source of cancer biomarkers, which have previously been found to provide enhanced specificity for other cancers. Glycosylation changes are a well-known hallmark in cancer development and progression, and can enable the specific detection of EV subpopulations originating from tumor cells. The objectives will include the identification and detection of tissue and disease specific EV-subsets with the use of novel bioaffinity reagents (lectins and antibodies).. The project will include the formulation and clinical validation of in vitro diagnostics assays of biological fluids with decisively improved capability for sensitive and specific detection of PCa tumor derived biomarker isoforms, thus providing superior tools for early detection/screening of PCa as ...
Somapacitan - AdisInsightSomapacitan - AdisInsight
Novo Nordisk is developing somapacitan, a long-acting human growth hormone derivative (also known as NN 8640 or NNC 0195 0092) for the treatment of growth
Owned: false BS article published in the Martialist - Page 15Owned: false BS article published in the Martialist - Page 15
Just when you thought The Martialist (Phil Elmore s online publication) was dead and gone, he publishes the mega issue which really means he missed 5 or so issues and chucked them all together. One of the few good things to come out of this literary classic is that it includes my article, written to test whether he verifies the effectiveness and veracity of the self-protection advice he prints. The homemade anti-knife vest Starts page 13:
Owned: false BS article published in the Martialist - Page 13Owned: false BS article published in the Martialist - Page 13
Just when you thought The Martialist (Phil Elmore s online publication) was dead and gone, he publishes the mega issue which really means he missed 5 or so issues and chucked them all together. One of the few good things to come out of this literary classic is that it includes my article, written to test whether he verifies the effectiveness and veracity of the self-protection advice he prints. The homemade anti-knife vest Starts page 13:
Plus itPlus it
Effects of opioid peptides on behavioral changes induced by stressful situations were investigated. [D-Ala2,Met5]-enkephalinamide and [D-Ala2,D-Leu5]-enkephalin, degrading-enzyme-resistant derivatives of methionine-enkephalin and leucine-enkephalin, respectively, significantly attenuated both environment-induced conditioned suppression of motility and forced swimming-induced immobility in a dose-dependent manner. The [D-Ala2,Met5]-enkephalinamide- and [D-Ala2,D-Leu5]-enkephalin-induced attenuations were antagonized by naloxone at different doses. In contrast, dynorphin A(1-17) and [N-methyl-Tyr1,N-methyl-Arg7,D-Leu8]-dynorphin A(1-8) ethylamide (E 2078), a degrading-enzyme-resistant derivative of dynorphin, significantly potentiated both behavioral changes. The dynorphin- and E 2078-induced potentiations were inhibited by Mr 2266. [D-Ala2,Met5]-enkephalinamide-induced attenuation of environment-induced conditioned suppression of motility and forced swimming-induced immobility was prevented by ...
Indian Patents. 253572:13-(N-BOC-ß-ISOBUTYLSERINYL) -14 ß-HYDROXYBACCATINE V 1, 14 OF FORMULA (I) AND COMPOSITIONS THEREOFIndian Patents. 253572:'13-(N-BOC-ß-ISOBUTYLSERINYL) -14 ß-HYDROXYBACCATINE V 1, 14 OF FORMULA (I) AND COMPOSITIONS THEREOF'
The mixture of the above crude nitrile VI (43 g) was treated with 150 ml of concentrated HCl (37%) (150 mL) and refluxed overnight to give the crude acid VII*. The hydrochloric acid excess was removed by rotatory evaporator and the residue was evaporated with water (100 mL) to remove HCl. The residue was then dissolved in 150 ml of water and added with 100 ml of acetone, then treated with 33 ml of a 6.25M NaOH solution to adjust pH to 5. A further amount of acetone (500 mL) was then added to the solution which was left to stand overnight at 4°C. The precipitated solid was subsequently filtered and the solid cake was washed with acetone and dried under vacuum to give crude acid VII (6.5 g) containing an about 3:1 mixture of 2(R),3(S) and 2(S),3(S) derivatives of compound VI ...
Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. | Sigma-AldrichAzelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [T Ohyama, K Sato, K Kishimoto, Y Yamazaki, N Horiguchi, T Ichikawa, S Kakizaki, H Takagi, T Izumi, M Mori].
Chemical glycobiology: new methods for stereoselective and automated glycosylations in the synthesis of biologically relevant...Chemical glycobiology: new methods for stereoselective and automated glycosylations in the synthesis of biologically relevant...
PhD Project - Chemical glycobiology: new methods for stereoselective and automated glycosylations in the synthesis of biologically relevant carbohydrate probes at University of York, listed on FindAPhD.com
Verapamil - HealtheryVerapamil - Healthery
Verapamil is a common calcium blocker sold under different names used to treat heart conditions as well as blood pressure and other conditions.
Protecting Yourself in Hostile EnvironmentsProtecting Yourself in Hostile Environments
... | SHIELD offers a self-protection course that learns you to operate under extreme conditions in conflict areas.
Shortys Sutures: Note to Self: Self-Protection is KeyShorty's Sutures: Note to Self: Self-Protection is Key
No, I dont want to learn to shoot because I could accidentally shoot the wrong person; No, I dont want to skydive because Id crap my pants and embarrass myself, then my parachute wouldnt open (which would make the crapping of my pants completely invisible); I really dont want to scuba dive because Im afraid my breathing apparatus will fail and Ill drown; I dont need to go through the process of getting a license to carry my gun on me because if I actually carry my gun I will most likely get mugged and the robber will take it from me and use it on me; No, Hubby you dont need to make that eight-hour drive to a tactical class youve always wanted to take by yourself because you could fall asleep behind the wheel and crash... ...
TCDB » SEARCHTCDB » SEARCH
Class I lantibiotic bacteriocin Gallidermin precursor (has a mersacidin-like Lipid II domain, and forms Lipid II-dependent pores) (Sahl and Bierbaum, 1998). The genetic organization, biosynthesis, modification, excretion, extracellular activation of the modified pre-peptide by proteolytic processing, self-protection of the producer, gene regulation, structure, and mode of action have been reviewed (Götz et al. 2014 ...
Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick...Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick...
Post a Comment for Effects of beta-aminopropionitrile, L-azetidine-2-carboxylic acid and beta-xyloside on the tunica media of the developing chick aorta : a mongraphic study by Susan Averill Taylor. ...
Olfactory bulbectomy induced oxidative and cell damage in rat: Protective effect of melatonin<...Olfactory bulbectomy induced oxidative and cell damage in rat: Protective effect of melatonin<...
TY - JOUR. T1 - Olfactory bulbectomy induced oxidative and cell damage in rat. T2 - Protective effect of melatonin. AU - Tasset, Inmaculada. AU - Medina, F. J.. AU - Peña, J.. AU - Jimena, I.. AU - muñoz, M. del Carmen. AU - Salcedo, M.. AU - Ruiz, C.. AU - Feijóo, M.. AU - Montilla, P.. AU - Túnez, I.. PY - 2010. Y1 - 2010. N2 - In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action ...
JAIRO | Volatile Glycosylation in Tea Plants: Sequential Glycosylations for the Biosynthesis of Aroma β-Primeverosides Are...JAIRO | Volatile Glycosylation in Tea Plants: Sequential Glycosylations for the Biosynthesis of Aroma β-Primeverosides Are...
Volatile Glycosylation in Tea Plants: Sequential Glycosylations for the Biosynthesis of Aroma β-Primeverosides Are Catalyzed by Two Camellia sinensis GlycosyltransferasesVolatile Glycosylation in Tea Plants: Sequential Glycosylations for the Biosynthesis of Aroma β-Primeverosides Are Catalyzed by Two Camellia sinensis GlycosyltransferasesAA12046875 ...
Martial arts, fighting or self-protection? | Iain AbernethyMartial arts, fighting or self-protection? | Iain Abernethy
Hello All, For me karate is a martial art, so therefore training is fighting, and fighting (in the healthy sense that it leads away from fear and paranoia) -as in combat sports. So when we perform our drills and basic techniques, we are putting them into a context where we can apply them against each other in such a way as to develop the underlying delivery system of the karate skills, and to develop our athleticism. In effect, what we do looks like MMA in a gi. I enjoy that game of using stand-up, clinch, ground, and wall/cage techniques together. Although we use our karate in this manner, what we do is not MMA, as no one at my gym competes in the cage, nor do we want to. We just enjoy the game. We are developing the physical skill sets required for fighting and self-defence (when in breaks down into fighting) in a fun and light manner. I emphasize athletic output with the use of non-damaging fighting technique (think as Judo was to the older battlefield Ju-Jitsu) to develop the qualities so ...
Nucleosides and Nucleotides. 208. Alternate-Strand Triple-Helix Formation by the 3-3-Linked Oligodeoxynucleotides with the...Nucleosides and Nucleotides. 208. Alternate-Strand Triple-Helix Formation by the 3'-3'-Linked Oligodeoxynucleotides with the...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Tackling the glycosylation of 2-deoxy-sugars: A reagent-controlled approach utilizing cyclopropenium cations for the α...Tackling the glycosylation of 2-deoxy-sugars: A reagent-controlled approach utilizing cyclopropenium cations for the α...
Abstract: Gaining access to stereodefined deoxy-sugar containing oligosaccharides, such as those containing 2,6-dideoxy and 2,3,6-trideoxy motifs, remains a formidable challenge. This is largely due to the difficulties associated with controlling the selectivity of glycosylations using deoxy-sugar donors. Herein, the development of three generations of reagent-controlled approaches utilizing cyclo... read morepropenium cations are described. Chapter 2 describes our first-generation approach which utilized a 3,3-dichloro-1,2-diphenylcyclopropene/tetrabutylammonium iodide (TBAI) promoter system for α-selective glycosylations. These substrates reacted with a range of glycosyl acceptors to afford products in 55 to 99% yield, with selectivities ranging from 3:1 α:β to all α, determined by NMR. In chapter 3 we describe how we improved upon the method by utilizing a 3,3-dibromo-1,2-diphenylcyclopropenone/TBAI system. This latter system activated deoxy-sugar donors to react with a range of glycosyl ...
PPT - Guns PowerPoint Presentation - ID:2815PPT - Guns PowerPoint Presentation - ID:2815
Only 13% of gun owners state that their guns are for self-protection only ... Nearly as many people die by guns as by auto accidents (deaths by auto accidents ... Slideshow 2815 by adamdaniel
codeblogcodeblog
Previously: v4.16.. Linux kernel v4.17 was released last week, and here are some of the security things I think are interesting:. Jailhouse hypervisor. Jan Kiszka landed Jailhouse hypervisor support, which uses static partitioning (i.e. no resource over-committing), where the root "cell" spawns new jails by shrinking its own CPU/memory/etc resources and hands them over to the new jail. Theres a nice write-up of the hypervisor on LWN from 2014.. Sparc ADI. Khalid Aziz landed the userspace support for Sparc Application Data Integrity (ADI or SSM: Silicon Secured Memory), which is the hardware memory coloring (tagging) feature in Sparc M7. Id love to see this extended into the kernel itself, as it would kill linear overflows between allocations, since the base pointer being used is tagged to belong to only a certain allocation (sized to a multiple of cache lines). Any attempt to increment beyond, into memory with a different tag, raises an exception. Enrico Perla has some great write-ups on using ...
Sensitive Soothing Scalp RestorerSensitive Soothing Scalp Restorer
The restorer is specially designed for sensitive and damaged scalp to soothe scalp symptoms caused by sensitivity, hair dye, or season changing. It effectively enhances your scalp self-protection system to a healthy state.
Muay Thai Self-Defence (dairy) | Clubb ChimeraMuay Thai Self-Defence (dairy) | Clubb Chimera
20.07.17. Tonights lesson brought my client to 10 hour point of his course, completing Basic Muay Thai for Martial Arts Cross Training. This is where I like to bring clients back to the self-protection line and look at ways to integrate their attribute training into this area.. This time I looked at one aspect of the fence - a posture termed "the pleading fence" by Geoff Thompson. I mention it briefly on my "Cross Training in the Martial Arts" DVD. It involves putting the hands up in a parallel position as if pleading. Such a tactic is often employed by some self-defence teachers who teach handgun disarms, where the hands frame the weapon. The problem with teaching a fence posture is that individuals can easily get hung up and fixated on that particular posture. Geoff Thompson told me that the stylization of the fence largely came from people seeing his diagrams and photos, and assuming that the fence was a static position. When I started seeing people using the fence as a blocking tool rather ...
silicon advocate- pheromone concerns - New Pheromone User Guide - Perfume Chat and Trading Postsilicon advocate- pheromone concerns - New Pheromone User Guide - Perfume Chat and Trading Post
hehehhe so Ive been doing some research on pheromones and cant quite find enough solid info on safety with regards to hormonal balance... please correct me if Im wrong but it seems that pheromones are hormone derivatives mostly (meaning they are the byproducts of hormones that have broken down) a...
Boettcher : Group : Prof. Dr. J. Thiem : Emeriti und Ehemalige : Organic Chemistry : Universität HamburgBoettcher : Group : Prof. Dr. J. Thiem : Emeriti und Ehemalige : Organic Chemistry : Universität Hamburg
Successfully completed his master degree in 2011 entitled "New studies of Glycosylations with Complex Oxianion Saccharide-Derivatives". A mechanistic illustration is shown in Scheme 1, illustrating the differences between conventional glycosylations using protecting group chemistry and by using a base promoted approach, which potentially allows for a reactivity based regioselective glycosylation. [1-2 ...
CombatiX FAQCombatiX FAQ
What is CombatiX™?. CombatiX™ is unlike any other combatives system out there! CombatiX™ is not simply Martial Arts. Instead, it is a highly specialized self-protection system developed extensively over decades of practical combative experience. We have evaluated and refined the techniques taught it many special forces and law enforcement programs to create an easy-to-learn and highly effective system of defensive tactics.. We have incorporated extensive knowledge of anatomy and physiology into CombatiX™. Most existing programs are based on Martial Arts systems which incorporate a block/punch/kick mentality to fighting. In those systems, brute force is favored. Unfortunately, this means that one has to have superior strength and size to be effective. With CombatiX™, training is focused on attacking the weaknesses of the human body.. For those who need or want to incorporate weapons, there is no need to learn a different system with highly specialized stances and techniques. With ...
Inflammation - The School of Biomedical Sciences WikiInflammation - The School of Biomedical Sciences Wiki
Inflammation is the bodys attempt at self-protection; the aim being to remove harmful stimuli, including damaged cells, irritants, or pathogens - and begin the healing process [1] ...
Gratitude Gourmet Blog - Gratitude GourmetGratitude Gourmet Blog - Gratitude Gourmet
I work in the pharmaceutical industry as a scientist and thus am very familiar with genetic engineering. We use it to engineer cell lines to produce the protein biologicals we engineer as medicines, such as antibodies. It is a common and well known concept that the species that one produces those proteins in matters very much, ie, if you take a single gene and express it in various species of cell lines, you will not get the same final protein due to something called post translational modifications. For example, the protein may have parts of it cut off, it may be folded differently, different phosphorylations may occur, or glycosylations (sugars) will get added on in different patterns. Sometimes those differences have little effect, and sometimes those effects are quite huge - you just dont know until you test it. This is what a lot of geneticists fail to convey when talking about genetic engineering. Sure, when you move DNA from species to another, that DNA is all made of the same ...
The knowledge and skills related to sexual abuse prevention among Chinese children with hearing loss in BeijingThe knowledge and skills related to sexual abuse prevention among Chinese children with hearing loss in Beijing
DOI: http://dx.doi.org/10.1016/j.dhjo.2016.12.014. Background. The prevalence of any child sexual abuse (CSA) experience before the age of 16 years ranges from 10.2 to 35.2% in China,1-5 but there has been no research so far exploring the level of awareness of CSA prevention and self-protection skills among Chinese children with hearing loss.. Objective. The school based survey examines the CSA prevention knowledge and self-protection skills in Chinese children with hearing loss.. Methods. Fifty-one students (30 boys, 21 girls) from 10 to 16 years old participated in the study. Childrens CSA prevention knowledge and self-protection skills were tested by using anonymous self-administered questionnaire which was mainly designed based on previous Chinese CSA research questionnaires, the Personal Safety Questionnaire, and the What If Situations Test (WIST). Results. There were ten questions assessing the knowledge of CSA but none of the children could correctly answer all and seventy percent of ...
Diet Pills Supermarket - Part 2Diet Pills Supermarket - Part 2
On Thursday, December 28th, 2017, researchers at Nanyang Technological University in Singapore announced theyd developed a skin path that delivers anti-obesity drugs to the body with a lower risk of side effect than that associated with the same drugs (including a thyroid hormone derivative) when they are administered via injection or swallowed in a pill.. However, there are similarities with an injection because the ingredients are housed in hundreds of micro-needles that embed in the skin when the slimming patch is applied and the degrade in a manner that feeds the white adipose tissue below the skin a drug that causes it to turn brown.. Researchers at Columbia University Medical Center in New York are working on something similar. The needles deliver nanoparticles that change the fat near the patch application area and, when details of the project hit the news in September 2017, it sparked a lot of interest.. Both micro-needle patches have been tested on mice. The researchers in Singapore ...
No EEE found in Brockton area so far this year - News - The Patriot Ledger, Quincy, MA - Quincy, MANo EEE found in Brockton area so far this year - News - The Patriot Ledger, Quincy, MA - Quincy, MA
This time last year, the region was abuzz with early findings of diseased mosquitoes carrying Eastern equine encephalitis, or EEE. This year, as of Friday, no mosquitoes have tested positive for the virus. Still, local and state health officials are urging people to get in the habit now of self-protection.
Fight-or-flight response - WikipediaFight-or-flight response - Wikipedia
Animals respond to threats in many complex ways. Rats, for instance, try to escape when threatened, but will fight when cornered. Some animals stand perfectly still so that predators will not see them. Many animals freeze or play dead when touched in the hope that the predator will lose interest.. Other animals have alternative self-protection methods. Some species of cold-blooded animals change color swiftly, to camouflage themselves.[29] These responses are triggered by the sympathetic nervous system, but, in order to fit the model of fight or flight, the idea of flight must be broadened to include escaping capture either in a physical or sensory way. Thus, flight can be disappearing to another location or just disappearing in place. And often both fight and flight are combined in a given situation.. The fight or flight actions also have polarity - the individual can either fight or flee against something that is threatening, such as a hungry lion, or fight for or fly towards something that is ...
BAE | Page 4 | SIGNAL MagazineBAE | Page 4 | SIGNAL Magazine
BAE Systems, Information and Electronic Systems Integration Incorporated, Nashua, New Hampshire, is being awarded a potential $41 million contract for four high-frequency wideband AN/SQQ-32(v)4 systems and associated engineering services and support that will detect and classify bottom and moored sea mines. The AN/SQQ-32(v)4 will be deployed from carriers for self-protection. High-frequency wideband AN/SQQ-32(v)4 will replace the in-service AN/SQQ-32(v)3 detection sonar and will improve detection performance and target resolution in high clutter environments including littoral zones and confined straits. ...
Weekly Neuroscience UpdateWeekly Neuroscience Update
Childhood poverty and chronic stress may lead to problems regulating emotions as an adult, according to research published online in the Proceedings of the National Academy of Sciences. New research shows that one of the brains fundamental self-protection mechanisms depends on coordinated, finely calibrated teamwork among neurons and non-neural cells knows as glial cells, which until…
SPECTRUM Aminopyrazine Carboxylic Acid,25g - 26WR20|A0848-5G - GraingerSPECTRUM Aminopyrazine Carboxylic Acid,25g - 26WR20|A0848-5G - Grainger
Looking for SPECTRUM Aminopyrazine Carboxylic Acid,25g (26WR20)? Graingers got your back. Price:$85.50. Easy ordering & convenient delivery. Log-in or register for your pricing.
Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine...Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine...
Animals, Area Under Curve, Blood Glucose/metabolism, Cardiovascular System, Ischemia, Lactic Acid/*chemistry, Microdialysis, Myocardial Infarction/pathology, Myocardium/metabolism/*pathology, Peptide Fragments/*chemistry/pharmacology, Protein Precursors/chemistry, Pyruvic Acid/*chemistry, Reperfusion Injury, Research Support; Non-U.S. Govt, Swine, Time Factors ...
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Synthesis of 4- to 7-membered Heterocycles by Ring Expansion | Springer for Research & DevelopmentSynthesis of 4- to 7-membered Heterocycles by Ring Expansion | Springer for Research & Development
Alfred Hassner - WikipediaAlfred Hassner - Wikipedia
KAKEN - Research Projects | Creation of Innovative Organocatalysts Using the Network of Intermolecular Interactions (KAKENHI...KAKEN - Research Projects | Creation of Innovative Organocatalysts Using the Network of Intermolecular Interactions (KAKENHI...
Index Catalog // Tesis y Disertaciones Electrónicas de EmoryIndex Catalog // Tesis y Disertaciones Electrónicas de Emory
Index Catalog // Emory Electronic Theses and DissertationsIndex Catalog // Emory Electronic Theses and Dissertations
Identifying signaling molecules from Gram-positive bacteria | Nature Research Chemistry CommunityIdentifying signaling molecules from Gram-positive bacteria | Nature Research Chemistry Community
Items where Author is Hemming, Karl - University of Huddersfield RepositoryItems where Author is Hemming, Karl - University of Huddersfield Repository
Items where School is School of Applied Sciences | Biomolecular Sciences Research Centre - University of Huddersfield...Items where School is "School of Applied Sciences | Biomolecular Sciences Research Centre" - University of Huddersfield...
No questions in Disopyramide - lookformedical.comNo questions in Disopyramide - lookformedical.com
No questions in Glycopyrrolate - lookformedical.comNo questions in Glycopyrrolate - lookformedical.com
Ximelagatran - DrugBankXimelagatran - DrugBank
新闻详细--上海交大化学化工学院新闻详细--上海交大化学化工学院
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