Azetidinecarboxylic Acid: A proline analog that acts as a stoichiometric replacement of proline. It causes the production of abnormal proteins with impaired biological activity.PyrazinesResearch: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Research Personnel: Those individuals engaged in research.Receptors, Opioid, mu: A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.Creatine Kinase, MM Form: An isoenzyme of creatine kinase found in the MUSCLE.Creatine Kinase: A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.Creatine: An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.Muscles: Contractile tissue that produces movement in animals.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.Phenylpropanolamine: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.Ephedrine: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.DirectoryFermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Physicochemical Phenomena: The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.Respiratory Protective Devices: Respirators to protect individuals from breathing air contaminated with harmful dusts, fogs, fumes, mists, gases, smokes, sprays, or vapors.Organosilicon Compounds: Organic compounds that contain silicon as an integral part of the molecule.Spiro Compounds: A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.Carbonic Acid: Carbonic acid (H2C03). The hypothetical acid of carbon dioxide and water. It exists only in the form of its salts (carbonates), acid salts (hydrogen carbonates), amines (carbamic acid), and acid chlorides (carbonyl chloride). (From Grant & Hackh's Chemical Dictionary, 5th ed)AzetidinesSkating: Using ice skates, roller skates, or skateboards in racing or other competition or for recreation.Protective Clothing: Clothing designed to protect the individual against possible exposure to known hazards.Transition Temperature: The temperature at which a substance changes from one state or conformation of matter to another.Mustard Compounds: Strong alkylating and immunosuppressive agents whose biological activity is based on the presence of bis(2-chloroethyl)- groups. Although otherwise structurally diverse, the compounds have in common the capacity to contribute alkyl groups to DNA. They are generally highly toxic but include among their number many widely used and effective antineoplastic agents.Glycyrrhetinic Acid: An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.Nitrosourea CompoundsMolecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Isoindoles: Benzopyrroles with the nitrogen at the number two carbon, in contrast to INDOLES which have the nitrogen adjacent to the six-membered ring.QuinoxalinesCarbamazepine: An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Nuclear Magnetic Resonance, Biomolecular: NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.Spectrum Analysis: The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Autonomic Nervous System: The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.Signal Processing, Computer-Assisted: Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.Location Directories and Signs: Directory signs or listings of designated areas within or without a facility.Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.Salvia miltiorrhiza: A plant species which is known as an Oriental traditional medicinal plant.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.

Effect of L-azetidine-2-carboxylic acid on glycosylations of collagen in chick-embryo tendon cells. (1/140)

The glycosylations of hydroxylysine during collagen biosynthesis in isolated chick-embryo tendon cells were studied by using pulse-chase labelling experiments with [14C]-lysine. The hydroxylation of lysine and the glycosylations of hydroxylysine continued after a 5 min pulse label for up to about 10 min during the chase period. These data differ from those obtained previously in isolated chick-embryo cartilage cells, in which, after a similar 5 min pulse label, these reactions continued during the chase period for up to about 20 min. The collagen synthesized by the isolated chick-embryo tendon cells differed markedly from the type I collagen of adult tissues in its degree of hydroxylation of lysine residues and glycosylations of hydroxylysine residues. When the isolated tendon cells were incubated in the presence of L-azetidine-2-carboxylic acid, the degree of glycosylations of hydroxylysine during the first 10 min of the chase period was identical with that in cells incubated without thcarboxylic acid for at least 60 min, whereas no additional glycosylations took place in the control cells after the 10 min time-point. As a consequence, the collagen synthesized in the presence of this compound contained more carbohydrate than did the collagen synthesized by the control cells. Additional experiments indicated that azetidine-2-carboxylic acid did not increase the collagen glycosyltransferase activities in the tendon cells or the rate of glycosylation reactions when added directly to the enzyme incubation mixture. Control experiments with colchicine indicated that the delay in the rate of collagen secretion, which was observed in the presence of azetidine-2-carboxylic acid, did not in itself affect the degree of glycosylations of collagen. The results thus suggest that the increased glycosylations were due to inhibition of the collagen triple-helix formation, which is known to occur in the presence of azetidine-2-carboxylic acid.  (+info)

Intracellular retention of procollagen within the endoplasmic reticulum is mediated by prolyl 4-hydroxylase. (2/140)

The correct folding and assembly of proteins within the endoplasmic reticulum (ER) are prerequisites for subsequent transport from this organelle to the Golgi apparatus. The mechanisms underlying the ability of the cell to recognize and retain unassembled or malfolded proteins generally require binding to molecular chaperones within the ER. One classic example of this process occurs during the biosynthesis of procollagen. Here partially folded intermediates are retained and prevented from secretion, leading to a build up of unfolded chains within the cell. The accumulation of these partially folded intermediates occurs during vitamin C deficiency due to incomplete proline hydroxylation, as vitamin C is an essential co-factor of the enzyme prolyl 4-hydroxylase. In this report we show that this retention is tightly regulated with little or no secretion occurring under conditions preventing proline hydroxylation. We studied the molecular mechanism underlying retention by determining which proteins associate with partially folded procollagen intermediates within the ER. By using a combination of cross-linking and sucrose gradient analysis, we show that the major protein binding to procollagen during its biosynthesis is prolyl 4-hydroxylase, and no binding to other ER resident proteins including Hsp47 was detected. This binding is regulated by the folding status rather than the extent of hydroxylation of the chains demonstrating that this enzyme can recognize and retain unfolded procollagen chains and can release these chains for further transport once they have folded correctly.  (+info)

Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression. (3/140)

The gene for the amino acid biosynthetic activity asparagine synthetase (AS) is induced by both amino acid and glucose deprivation of cells. The data reported here document that the human AS gene is induced following activation of the Unfolded Response Pathway (UPR), also known as the Endoplasmic Reticulum Stress Response (ERSR) in mammals. Increased AS transcription occurs in response to glucose deprivation, tunicamycin, or azetidine-2-carboxylate, all known to activate the UPR/ERSR pathway. Previously identified ERSR target genes contain multiple copies of a single highly conserved cis-element. In contrast, the human AS gene does not contain the ERSR element, as it has been described for other responsive genes. Instead, AS induction requires an Sp1-like sequence, a sequence previously shown to be associated with amino acid control of transcription, and possibly, a third region containing no consensus sequences for known transcription factors. Oligonucleotides covering each of these regions form DNA-protein complexes in vitro, and for some the amount of these complexes is greater when nuclear extracts from glucose-starved cells are tested. These results document that a wider range of metabolic activities are activated by the UPR/ERSR pathway than previously recognized and that genomic elements other than those already described can serve to enhance transcription of specific target genes.  (+info)

Upregulation of cytosolic chaperonin CCT subunits during recovery from chemical stress that causes accumulation of unfolded proteins. (4/140)

The chaperonin containing TCP-1 (CCT) is a molecular chaperone consisting of eight subunit species and assists in the folding of actin, tubulin and some other cytosolic proteins. We examined the stress response of CCT subunit proteins in mammalian cultured cells using chemical stressors that cause accumulation of unfolded proteins. Levels of CCT subunit proteins in HeLa cells were coordinately and transiently upregulated under continuous chemical stress with sodium arsenite. CCT subunit levels in several mammalian cell lines were also upregulated during recovery from chemical stress caused by sodium arsenite or a proline analogue, L-azetidine-2-carboxylic acid. Several unidentified proteins that were newly synthesized and associated with CCT were found to increase concomitantly with CCT subunits themselves and known substrates during recovery from the stress. These results suggest that CCT plays important roles in the recovery of cells from protein damage by assisting in the folding of proteins that are actively synthesized and/or renatured during this period.  (+info)

Saccharomyces cerevisiae sigma 1278b has novel genes of the N-acetyltransferase gene superfamily required for L-proline analogue resistance. (5/140)

We discovered on the chromosome of Saccharomyces cerevisiae Sigma 1278b novel genes involved in L-proline analogue L-azetidine-2-carboxylic acid resistance which are not present in the standard laboratory strains. The 5.4 kb-DNA fragment was cloned from the genomic library of the L-azetidine-2-carboxylic acid-resistant mutant derived from a cross between S. cerevisiae strains S288C and Sigma 1278b. The nucleotide sequence of a 4.5-kb segment exhibited no identity with the sequence in the genome project involving strain S288C. Deletion analysis indicated that one open reading frame encoding a predicted protein of 229 amino acids is indispensable for L-azetidine-2-carboxylic acid resistance. The protein sequence was found to be a member of the N-acetyltransferase superfamily. Genomic Southern analysis and gene disruption showed that two copies of the novel gene with one amino acid change at position 85 required for L-azetidine-2-carboxylic acid resistance were present on chromosomes X and XIV of Sigma 1278b background strains. When this novel MPR1 or MPR2 gene (sigma 1278b gene for L-proline analogue resistance) was introduced into the other S. cerevisiae strains, all of the recombinants were resistant to L-azetidine-2-carboxylic acid, indicating that both MPR1 and MPR2 are expressed and have a global function in S. cerevisiae.  (+info)

Induced activity of adenine phosphoribosyltransferase (APRT) in iron-deficiency barley roots: a possible role for phytosiderophore production. (6/140)

To isolate the genes involved in the response of graminaceous plants to Fe-deficient stress, a protein induced by Fe-deficiency treatment was isolated from barley (Hordeum vulgare L.) roots. Based on the partial amino acid sequence of this protein, a cDNA (HvAPT1) encoding adenine phosphoribosyltransferase (APRT: EC 2.4.2.7) was cloned from a cDNA library prepared from Fe-deficient barley roots. Southern analysis suggested that there were at least two genes encoding APRT in barley. Fe deficiency increased HvAPT1 expression in barley roots and resupplying Fe to the Fe-deficient plants rapidly negated the increase in HvAPT1 mRNA. Analysis of localization of HvAPT1-sGFP fusion proteins in tobacco BY-2 cells indicated that the protein from HvAPT1 was localized in the cytoplasm of cells. Consistent with the results of Northern analysis, the enzymatic activity of APRT in barley roots was remarkably increased by Fe deficiency. This induction of APRT activity by Fe deficiency was also observed in roots of other graminaceous plants such as rye, maize, and rice. In contrast, the induction was not observed to occur in the roots of a non-graminaceous plant, tobacco. Graminaceous plants generally synthesize the mugineic acid family phytosiderophores (MAs) in roots under Fe-deficient conditions. In this paper, a possible role of HvAPT1 in the biosynthesis of MAs related to adenine salvage in the methionine cycle is discussed.  (+info)

Hydroxylated phytosiderophore species possess an enhanced chelate stability and affinity for iron(III). (7/140)

Graminaceous plant species acquire soil iron by the release of phytosiderophores and subsequent uptake of iron(III)-phytosiderophore complexes. As plant species differ in their ability for phytosiderophore hydroxylation prior to release, an electrophoretic method was set up to determine whether hydroxylation affects the net charge of iron(III)-phytosiderophore complexes, and thus chelate stability. At pH 7.0, non-hydroxylated (deoxymugineic acid) and hydroxylated (mugineic acid; epi-hydroxymugineic acid) phytosiderophores form single negatively charged iron(III) complexes, in contrast to iron(III)-nicotianamine. As the degree of phytosiderophore hydroxylation increases, the corresponding iron(III) complex was found to be less readily protonated. Measured pKa values of the amino groups and calculated free iron(III) concentrations in presence of a 10-fold chelator excess were also found to decrease with increasing degree of hydroxylation, confirming that phytosiderophore hydroxylation protects against acid-induced protonation of the iron(III)-phytosiderophore complex. These effects are almost certainly associated with intramolecular hydrogen bonding between the hydroxyl and amino functions. We conclude that introduction of hydroxyl groups into the phytosiderophore skeleton increases iron(III)-chelate stability in acid environments such as those found in the rhizosphere or the root apoplasm and may contribute to an enhanced iron acquisition.  (+info)

Protein misfolding and temperature up-shift cause G1 arrest via a common mechanism dependent on heat shock factor in Saccharomycescerevisiae. (8/140)

Accumulation of misfolded proteins in the cell at high temperature may cause entry into a nonproliferating, heat-shocked state. The imino acid analog azetidine 2-carboxylic acid (AZC) is incorporated into cellular protein competitively with proline and can misfold proteins into which it is incorporated. AZC addition to budding yeast cells at concentrations sufficient to inhibit proliferation selectively activates heat shock factor (HSF). We find that AZC treatment fails to cause accumulation of glycogen and trehalose (Msn2/4-dependent processes) or to induce thermotolerance (a protein kinase C-dependent process). However, AZC-arrested cells can accumulate glycogen and trehalose and can acquire thermotolerance in response to a subsequent heat shock. We find that AZC treatment arrests cells in a viable state and that this arrest is reversible. We find that cells at high temperature or cells deficient in the ubiquitin-conjugating enzymes Ubc4 and Ubc5 are hypersensitive to AZC-induced proliferation arrest. We find that AZC treatment mimics temperature up-shift in arresting cells in G1 and represses expression of CLN1 and CLN2. Mutants with reduced G1 cyclin-Cdc28 activity are hypersensitive to AZC-induced proliferation arrest. Expression of the hyperstable Cln3-2 protein prevents G1 arrest upon AZC treatment and temperature up-shift. Finally, we find that the EXA3-1 mutation, encoding a defective HSF, prevents efficient G1 arrest in response to both temperature up-shift and AZC treatment. We conclude that nontoxic levels of misfolded proteins (induced by AZC treatment or by high temperature) selectively activate HSF, which is required for subsequent G1 arrest.  (+info)

*List of MeSH codes (D02)

... azetidinecarboxylic acid MeSH D02.241.081.583.400 --- technetium tc 99m diethyl-iminodiacetic acid MeSH D02.241.081.583.450 ... azetidinecarboxylic acid MeSH D02.491.485.400 --- technetium tc 99m diethyl-iminodiacetic acid MeSH D02.491.485.450 --- ... edetic acid MeSH D02.241.081.038.455 --- egtazic acid MeSH D02.241.081.038.581 --- iodoacetic acid MeSH D02.241.081.038.581.400 ... muramic acids MeSH D02.241.081.844.562 --- neuraminic acids MeSH D02.241.081.844.562.668 --- sialic acids MeSH D02.241.081.844. ...

*List of MeSH codes (D03)

... azetidinecarboxylic acid MeSH D03.383.097.217 --- aziridines MeSH D03.383.097.217.300 --- carbazilquinone MeSH D03.383.097.217. ... pipemidic acid MeSH D03.383.725.547.650 --- piromidic acid MeSH D03.383.725.547.900 --- 3-pyridinecarboxylic acid, 1,4-dihydro- ... niflumic acid MeSH D03.066.515.635 --- pipemidic acid MeSH D03.066.515.650 --- piromidic acid MeSH D03.066.515.950 --- ... nalidixic acid MeSH D03.438.810.835.055.550 --- nedocromil MeSH D03.438.810.835.055.580 --- oxolinic acid MeSH D03.438.810.835. ...

*List of MeSH codes (D12.125)

... imino acids MeSH D12.125.072.401.200 --- azetidinecarboxylic acid MeSH D12.125.072.401.623 --- proline MeSH D12.125.072.401. ... aspartic acid MeSH D12.125.067.500.150 --- d-aspartic acid MeSH D12.125.067.500.275 --- isoaspartic acid MeSH D12.125.067.500. ... 2-aminoadipic acid MeSH D12.125.119.170 --- aspartic acid MeSH D12.125.119.170.150 --- d-aspartic acid MeSH D12.125.119.170.275 ... glutamic acid MeSH D12.125.119.450.150 --- 1-carboxyglutamic acid MeSH D12.125.119.450.400 --- glutamates MeSH D12.125.119.450. ...
Azelnidipine plus olmesartan versus amlodipine plus olmesartan on arterial stiffness and cardiac function in hypertensive patients: a randomized trial Takeshi Takami,1 Yoshihiko Saito21Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan; 2First Department of Internal Medicine, Nara Medical University, Kashihara, JapanPurpose: To compare the long-term effects of olmesartan combined with either azelnidipine or amlodipine on central blood pressure (CBP), left ventricular (LV) mass index (LVMI), LV diastolic function (e´ velocity, E/e´ ratio, E/A ratio) and arterial stiffness (brachial-ankle pulse wave velocity [baPWV] and augmentation index normalized for a heart rate of 75 bpm [AIx]).Patients and methods: Patients with systolic BP ≥140 mmHg and/or diastolic BP ≥ 90 mmHg received olmesartan monotherapy (20 mg/day) for 12 weeks. They were then randomly assigned to fixed-dose add-on therapy with azelnidipine (16 mg/day; n = 26) or amlodipine (5 mg/day; n = 26) for a further 2 years. CBP,
Root release of phytosiderophores (PSs) is an important step in iron (Fe) acquisition of grasses, and this adaptive reaction of plants is affected by various plant and environmental factors. The objectives of this study were to study the effects of varied nitrogen (N) supply on (1) root and leaf concentrations of methionine, a precursor in the PS biosynthesis, (2) PS release from roots, (3) mobilization and uptake of Fe from (59) Fe-labeled Fe(III)-hydroxide [(59) Fe(OH)(3) ] and (4) root uptake of (59) Fe-labeled Fe(III)-deoxymugineic acid (DMA) by durum wheat (Triticum durum, cv. Balcali2000) plants grown in a nutrient solution. Enhanced N supply from 0.5 to 6 mM in a nutrient solution significantly increased the root release of PS under Fe deficiency. High N supply was also highly effective in increasing mobilization and root uptake of Fe from (59) Fe-hydroxide under low Fe supply. With adequate Fe, N nutrition did not affect mobilization and uptake of Fe from (59) Fe(OH)(3) . Root uptake and shoot
Barley (Hordeum vulgare), which tolerates iron (Fe) deficiency, secretes a large amount of phytosiderophores from its roots. However, how barley is able to allocate resources for phytosiderophore synthesis when the carbon assimilation rate is reduced by Fe deficiency is unknown. We previously suggested that the acceleration of senescence in older leaves triggered by Fe deficiency may allow the recycling of assimilates to contribute to phytosiderophore synthesis. In this work, we show the relationship between an increase in the C/N ratio in older leaves and Fe-deficiency tolerance among three barley cultivars. The increase in the C/N ratio suggests an enhanced capacity for the retranslocation of carbohydrates or amino acids from older leaves to the sink organs. An increase in the sucrose concentration in Fe-deficient barley also suggests active redistribution of assimilates. This metabolic modulation may be supported by accelerated senescence of older leaves, as Fe deficiency increased the ...
It has been suggested that some perennial grasses secrete phytosiderophores in response to iron (Fe) deficiency, but the compounds have not been identified. Here, we identified and characterized the phytosiderophores secreted by two perennial grasses
We investigated the impact of lowering blood pressure (BP) with azelnidipine, a newly developed calcium channel blocker, generation on the left ventricular (LV) diastolic function and LV filling pressure by assessing non-invasive indices derived from echo Doppler study. This study evaluated 232 hypertensive patients with diastolic dysfunction. This study had two groups: (1) in which azelnidipine was administered to patients as a first-line therapy, and (2) in which amlodipine was converted to azelnidipine. Early diastolic mitral annulus velocity (e, cm s(-1)), the ratio of peak E velocity to e velocity (E/e ratio) and level of brain natriuretic peptide (BNP) were measured before and, an average of, 8 months after azelnidipine treatment ...
Summary of Facts and Submissions. I. This appeal lies from the decision of the Examining Division to refuse the European application No. 99. 941 923.7 (publication No. 1 098 876) on the ground that the claims according to the then pending request did not comply with the requirements of Articles 84 and 56 EPC.. II. The request refused by the Examining Division was the set of ten claims as originally filed. Independent Claim 1 and dependent Claims 6, 8 and 9 read as follows:. 1. A process for the cyclisation of 4-amino-2- halobutyric acid to azetidine-2-carboxylic acid wherein more than 20 g of 4-amino-2-halobutyric acid is cyclised per litre of reaction mixture.. 6. A process as claimed in any of claims 1 to 5, characterized in that the 4-amino-2-halobutyric acid is added as its hydrohalide salt to hot aqueous base.. 8. A process as claimed in claim 6 or claim 7, characterised in that the base is at a temperature of more than 80°C.. 9. A process as claimed in any one of claims 6 to 8, ...
Structure, properties, spectra, suppliers and links for: 4-[4-Oxo-3-(phenylsulfanyl)-3,4-dihydro-1H,2H-spiro[azetidine-2,1-naphthalen]-1-yl]benzaldeh.
A cover plate, having a lower, flat surface containing an array of numerous, parallel, closely spaced apart, downwardly opening channels, is releasably clamped upon a flat support plate surface. The channels each have inlet and outlet holes communicating with the upper surface of the cover plate. A paper-like, resilient cushion sheet is clamped between the plate surfaces and a paper-like membrane, carrying a pattern of antigen-like material, is arranged between the sheet and the cover plate channeled surface. The channels are very narrow, shallow and many times longer than their widths and are closed by the stripe-like portions of the membrane which overlie the channels. The cushion sheet is compressed between adjacent channels and bulges upwardly at each of the channels to thereby bulge the membrane stripe-like portions into dome-shaped cross-sections extending into the channels. This reduces the volumes of the channels and increases the surface areas of the membrane stripe-like portions that are
Japans largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
The cytocidal activity of arabinosyl-5-azacytosine (araAC) and its effect on the synthesis and methylation of DNA in the human colon carcinoma cell line HT-29 was examined and compared with three other cytidine analogues. Treatment for 2 hr with 10(-6)M arabinosylcytosine (araC), araAC, 5-azacytidine (AZC), or 2-deoxy-5-azacytidine (dAZC) produced a 7-30% reduction in cell viability. Prolongation of drug exposure to 24 hr significantly enhanced the cytotoxicity of all analogues, and particularly dAZC. AZC and dAZC were potent inhibitors of DNA methylation in the absence of inhibition of DNA synthesis, whereas araC and araAC primarily affected DNA synthesis. RNA synthesis was not affected by any of the analogues. dAZC and AZC were incorporated into DNA to a greater extent than were araC or araAC upon short- and long-term drug exposure, whereas only AZC was incorporated into RNA. These data indicate that araAC appears to behave more as an analogue of araC rather than of dAZC or AZC, wherein it ...
Free Form Amino Acid 500 mg Vegetarian 90 Capsules Feature summary L-Arginine supports muscle metabolism and also is required in the formation of nitric oxide, a compound involved in the circulatory system.* Natural Factors amino acids are the highest quality pharmaceutical grade products available. Suggested Usage 2 capsules 1-3 times per day or as... ...
T00609 (aalt,achr,acta,actc,amyb,amyc,asw,cmos,cthd,cyl,dfn,ehl,fek,fva,hta,kak,kmx,kpnk,lei,lfb,lsh,lys,mcol,msub,mtab,noe,oor,paru,phs,pje,png,ptd,rpln,sclo,scou,seny,sera,sfz,slb,slw,snl,sphc,sphy,srub,taj : calculation not yet completed ...
This trial will investigate the efficacy and the renal- and lipid metabolism-effects of olmesartan medoxomil, in combination with either azelnidipine or
Pregnant Wistar rats were injected i.p. with 5-azacytidine (5AzC) at 11 day of gestation. Brain cell apoptosis determined morphologically or by TUNEL method was observed in the fetuses 3 hrs after injection. Eight to 100% of the fetuses were dead at 1 to7 day after injection. Injection with doses less than 5 mg/kg of 5AzC killed only a few fetuses, though neuronal apoptosis was detected in most of living fetuses. All fetuses were dead when their dams were injected with 5AzC at 9 or 10 day of gestation, whereas most of the fetuses were alive when injected after day 12. The present study revealed that 5AzC specifically induce neuronal apoptosis in rat fetuses at the stage of logarithmic growth.. ...
Find great deals for Micorrizas Arbusculares y Bacterias Solubilizadoras de Fosfatos by Rosario Azc N, Jos Miguel Barea, Marcia Toro (Paperback / softback, 2012). Shop with confidence on eBay!
Baku. 7 July. REPORT.AZ/ During the subsequent period the State Oil Company of Azerbaijan Republic (SOCAR) signed 810 mln AZN agreement with related parties for acquisition of the Methanol Plant.. Report informs, says consolidated financial statement of the company in accordance with International Financial Reporting Standards 2016. The report was audited by Ernst & Young (EY).. According to agreement, SOCAR has made 394 mln AZN prepayment to seller.. ...
This study demonstrated that AZL was a selective and insurmountable AT1 receptor antagonist and that it had high affinity to AT1 receptors. In particular, it remained substantially bound to the receptors after washout of the compound compared with other ARBs, such as olmesartan, telmisartan, valsartan, and irbesartan. Furthermore, the inhibitory effects of AZL on IP1 accumulation and vasoconstriction induced by AII persisted even after washout, whereas those of other ARBs were markedly attenuated.. We could not directly determine the dissociation rates of compounds from the AT1 receptor because the relevant radiolabeled compounds were not available. However, the potency of compounds for AT1 receptor antagonism for olmesartan, telmisartan, valsartan, and irbesartan observed in the washout experiment was almost comparable to the rank order of their dissociation half-life reported in recent studies; that is, olmesartan , telmisartan , valsartan , irbesartan (Van Liefde and Vauquelin, 2009). ...
2. Self and No Self ...Dharma Talk ...Albuquerque Zen Center. http://www.azc.org/azc/azc-talk-2000-04.html. When we divide our experience into self and world, we see ourselves as here (with a corresponding interior world) and the world over there - outside and around us. We see our lives as a series of interactions between the outside, the objective world, and our interior subjective world.. In this view, our self and our subjective content are almost synonymous. We feel responsible for our inner world of thoughts, memories and emotions. Our relationship with the outer world is often expressed as reaching out and perceiving experience. This viewpoint is inherently centered on what we think our self does. We believe our self is an actor on the worlds stage. This is an admittedly simple, broad model. Even though it leaves many questions unanswered, it readily corresponds to our sense of everyday life. Many people go through life without ever questioning this basic scheme.. If the ...
Zona Libera Braila ofera spre inchiriere sau concesionare de terenuri si constructii pe o perioada maxima de 49 de ani, inchirierea de terenuri si constructii pe o perioada maxima de 5 ani, inchirierea de cladiri si platforme pentru depozitare, plasare marfuri straine si romanesti, bunurile din zona libera pot fi ransportate in alta zona libera fara plata de taxe vamale, incarcarea si descarcarea, manipularea si sortarea marfurilor.
Ok, Ive read enough talk, and seen enough pictures of hammocks, that Ive started to think seriously about trying it again. Id likely make my own, and Im thinking of incorporating my Solo 12 (2lbs,2oz) http://www.thenorthface.com/opencms/opencms/tnf/gear.jsp?site=EU&model=AZC4 just fabricating a support system and using an Asolo Wing (med), for my tarp. Id likely modify the head and top panels, putting mesh in and creating 2 roll-down flys, because of the condensation inherent in a
Dec 28, 2016. Loss of Zetia and Vytorins revenues might have a negative impact on. PFE Lipitor, Astrazenecas AZN Crestor, and Novartis NVS
LUniversité Saint-Esprit de Kaslik (USEK) est une institution catholique privée denseignement supérieur fondée en 1961 par lOrdre Libanais Maronite (OLM).
article{2100766, abstract = {The efficient asymmetric synthesis of new chiral gamma-chloro-alpha,beta-diamino acid derivatives via highly diastereoselective Mannich-type reactions of N-(diphenylmethylene) glycine esters across a chiral alpha-chloro-N-p-toluenesulfinylimine was developed. The influence of the base, LDA or LiHMDS, used for the formation of the glycine enolates, was of great importance for the anti-/syn-diastereoselectivity of the Mannich-type reaction. The gamma-chloro-alpha,beta-diamino acid derivatives proved to be excellent building blocks for ring closure towards optically pure anti-and syn-beta,gamma-aziridino-alpha-amino esters, and subsequent ring transformation into trans-3-aminoazetidine-2-carboxylic acid derivatives and alpha,beta-diamino-gamma-butyrolactones.}, author = {Callebaut, Gert and Mangelinckx, Sven and Kiss, Lorand and Sillanpaa, Reijo and Fulop, Ferenc and De Kimpe, Norbert}, issn = {1477-0520}, journal = {ORGANIC \& BIOMOLECULAR CHEMISTRY}, keyword = ...
The rectangular calibration chart 1 comprises a plurality of parallel stripe-like color patches that are distributed into groups 11, ..., 14 of adjacent color patches 111, 112, 113, 114, ..., 118, each stripe-like color patch having a uniform calibration color. The calibration colors of the different stripe-like color patches are regularly distributed in a perceptually uniform visual color space. Thank to this regular distribution, the best compromise can be found between the lowest number of different color patches and the highest accuracy of the calibration of a given color device. Such a calibration chart is advantageously used to correction of non-uniformities of the color device.
Iron (Fe) toxicity in plants causes tissue damage and cellular homeostasis disorders, thereby affecting plant growth and development. Nicotianamine (NA) is a ubiquitous chelator of metal cations and is responsible for metal homeostasis. Rice has three NA synthase (NAS) genes, of which the expression of OsNAS1 and OsNAS2 but not of OsNAS3 is strongly induced in response to Fe deficiency. Recently, we found that OsNAS3 expression is strongly induced with excess Fe in most rice tissues, particularly old leaves, suggesting that it may play a vital role under excess Fe conditions. However, the mechanism by which OsNAS3 responds to excess Fe in rice remains poorly understood. In this study, we clarified the physiological response of OsNAS3 expression to excess Fe and the role of NA synthesis in this condition. Promoter GUS analyses revealed that OsNAS3 was widely expressed in roots, especially in vascular bundle, epidermis, exodermis, stem, and old leaf tissues under Fe excess compared to control plants.
The report generally describes azetidine hydrochloride, examines its uses, production methods, patents. Azetidine Hydrochloride market situation is
Accumulated evidence suggests that an altered ambulatory blood pressure (BP) profile, particularly elevated nighttime BP, reflects target organ injury and is a better predictor of further cardiorenal risk than the clinic BP or daytime BP in hypertens
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Copyright © 2000-2017 Sports Reference LLC. All rights reserved.. Much of the play-by-play, game results, and transaction information both shown and used to create certain data sets was obtained free of charge from and is copyrighted by RetroSheet.. Win Expectancy, Run Expectancy, and Leverage Index calculations provided by Tom Tango of InsideTheBook.com, and co-author of The Book: Playing the Percentages in Baseball.. Total Zone Rating and initial framework for Wins above Replacement calculations provided by Sean Smith.. Full-year historical Major League statistics provided by Pete Palmer and Gary Gillette of Hidden Game Sports.. ...
Definition of olm in the Definitions.net dictionary. Meaning of olm. What does olm mean? Information and translations of olm in the most comprehensive dictionary definitions resource on the web.
The Office of Labor-Management Standards (OLMS) in the U.S. Department of Labor is the Federal agency responsible for administering and enforcing most provisions of the Labor-Management Reporting and Disclosure Act of 1959, as amended (LMRDA).
AstraZenecas FY09 operational performance showed it was able to benefit from the opportunities created by the shortage in supply of generic Toprol XL and the swine flu vaccine, while also decreasing its working capital by $1.3bn. However, its shares trade at a considerable discount to its peers (FY09 P/E of 7.4x vs 12.5x) because of exaggerated concerns about the patent cliff. The five-year guidance suggests that revenues could be 15% higher than 2014 consensus forecasts. Cautious on 2010, but more optimism thereafter Although AstraZeneca reported adjusted EPS 8% below consensus estimates for Q4 09 and tempered expectations for 2010, it presented optimistic guidance for the next five years. The company believes that revenues in 2014 will be nearing $34bn, c 3% higher than in 2009, while consensus estimates suggest they will be 13% lower. Confidence of overcoming looming patent cliff This suggests AstraZeneca is confident about negotiating the challenges caused by patent expiries on key products ...
Equities News is a provider of business news and financial information covering full-form economic development and impact coverage of events, leaders and initiatives worldwide to over 40 million households.
BULGULAR: al maya dahil edilen 72 olgunun 48 i (%67) erkek, 24 (%33) k z idi. Kromozom analizlerinde, 69 olguda (%96) reg ler trizomi, 2 olguda (%3) mozaik, 1 olguda (%1.4) ise translokasyon paterni tespit edildi. Olgular n g z muayenelerinde; refraksiyon kusuru (%85), yukar kapak e imi (%68), epikantus (%63), a l k (%33), blefarit (%22), retina anomalileri (%19), katarakt (%19), nazolakrimal kanal t kan kl (%17), Brushfield lekesi (%17), kapak gev ekli i (%11), nistagmus (%4) ve keratokonus (%3) tespit edilirken; sistemik hastal k olarak konjenital kalp hastal (%36), hipotroidizm (%31), geli me gerili i (%7), i itme azl (%6), inmemi testis (%4), ast m (%4), Hirschsprung hastal (%1.4) ve otizm (%1.4) saptand . Olgular n 11 inde (%15) hi bir g z patolojisine rastlan lmad gibi, 13 olguda (%19) sistemik hastal a rastlanmad . En s k astigmatizma (%68) tespit edilirken bunu s ras yla hipermetropi (%47) ve miyopi (%19) izledi. Konjenital kalp hastal klar ndan ise en s k septum defektleri (%33) tespit ...
Hello Ladies. Well, once again I find myself here wanting to try again. I have 2 children. My DD (dear daughter) is almost 5 (FET) and my DS (dear son) is 1 today (IVF). It was a rough journey to get where we are now, but well worth it. We are truely blessed. I have been wanting to do another FET for a while now. My DH (dear husband) also wants to, but we just can´t afford it. I am just stepping out in faith I guess and leaving it up to God to work the money side out for me. So I am hoping and praying to be able to do FET in Jan or Feb. We have 4 day 5 blasts left and am hoping to transfer 2. Anyone else out there that is planning or even hoping to do IVF (in vitro fertilization) or FET in Jan or Feb 2013? It is so great to have this support. No one around me seems to understand what I go through. Spreadsheet bellow: https://docs.google.com/spreadsheet/ccc?key=0ArqlhRknIz06dGVnajhLTDVqTFdCMG1EUjJ1azl3dnc#gid=0
Amlodipine causes marked coronary and peripheral arterial vasodilation (which leads to plasma leakage in dependent areas since the veins remain constricted). As happens with other dihydropyridine calcium blockers, this results in a small percentage of patients having a problem with pedal edema (Am J Med. 2004;116:35-43). The pedal edema is not related to congestive heart failure and responds only inconsistently to diuretics, but it is not harmful.Mungkin akan nmpk sedikit gemuk sbb berlaku edema/bengkak.. ...
Iron is an essential element for plant growth and development, and iron deficiency is the most common micronutrient deficiency in the world. To cope with iron deficiency, plants have evolved two distinct mechanisms for Fe acquisition from the rhizosphere. Strategy I, found in all dicots and monocots with the exception of graminaceous species, is characterized by (1) release of protons to acidify the rhizosphere, which is mediated in Arabidopsis (Arabidopsis thaliana) by the proton-translocating ATPase AHA2 (ARABIDOPSIS PLASMA MEMBRANE H+-ATPASE ISOFORM 2; Curie and Briat, 2003; Santi and Schmidt, 2009); (2) inducing ferric chelate reductase activity mediated by FRO2 (FERRIC REDUCTASE OXIDASE2; Robinson et al., 1999); and (3) uptake of Fe2+ by the metal transporter IRT1 (IRON REGULATED TRANSPORTER1; Eide et al., 1996; Vert et al., 2002). Strategy II, utilized by graminaceous monocots (Römheld and Marschner, 1986), is characterized by enhanced release of phytosiderophores that form chelates with ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
AZN Azian Cuizine Restaurants in Naples: Read reviews written by 10Best experts and explore user ratings. In keeping with the spirit of fine food at Mercato center, AZN redefines our childhood notions of chow mein and fried rice to bring gourmet, pan-Asian fare in an impressive high-ceilinged dining room that spills out on the sidewalk around its swank bar. Indonesian chicken satay, Mongolian beef tacos, Vietnamese spring rolls, Hong Kong style lettuce wraps, sake mussels and Indian roti flatbread take their cues from the Far East. And thats just the appetizer menu. Dumplings, meat and poultry, seafood, rice and noodle dishes range from Korean beef short ribs to Japanese eggplant. Sushi plays an important role on an extensive menu where creative specialty rolls balance with traditional rolls, sashimi, nigiri and sushi.
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The concept of lethal mutagenesis has been developed as a means of curing viral infections and has also been used to explain the action of some antiviral drugs. Although mutation is the basis for adaptation and survival, especially in the presence of antiviral drugs, most mutations are detrimental and the theory of lethal mutagenesis holds that an infecting population can be pushed to extinction by an overwhelmingly high mutation rate. Chemical mutagens have been used to increase error rates in a number of RNA viruses including HIV-1 and HCV and have been found to significantly reduce viral titres and, in some cases, achieve extinction. For example, the antiviral activity of the ribonucleoside analogue 5-azacytidine (5-AZC) against HIV-1 has been attributed primarily to an increase in mutant frequency consistent with lethal mutagenesis caused by incorporation of 5-AZC into viral DNA.. A team of researchers from the University of Texas at Austin have now raised serious concerns about the ...
Stock analysis for AstraZeneca PLC (AZN:London) including stock price, stock chart, company news, key statistics, fundamentals and company profile.
These were able to get followed for recurrence of urothelial cancer from Inhibitors,Modulators,Libraries two months up to 59 months. This permitted an analysis of 18 recurrences and 29 non recur rences in individuals yielding cytologies with MT 3 constructive cells and seven recurrences and 24 non recurrences in individuals yielding cytologies without any MT 3 beneficial cells. A com parison on the time to recurrence involving these two groups unveiled a significant statistical difference in between individuals with urinary cytologies with MT three staining cells and people with no MT 3 staining cells. Discussion The first objective of this review was to determine if epige netic modification was accountable for that silencing from the MT 3 gene within the parental UROtsa cell line. Deal with ment with the parental UROtsa cells with five AZC, a com monly applied agent to find out DNA methylation standing, was shown to possess no effect on MT three mRNA expres sion.. This gives proof the MT three ...
Verapamil is a common calcium blocker sold under different names used to treat heart conditions as well as blood pressure and other conditions.
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In order to preserve a balance between the requirement for iron and its toxicity, plants likely maintain tight control over iron homeostasis. We are interested in identifying factors involved in the regulation of iron uptake and have examined this response in the reference plant Arabidopsis thaliana. Work presented in this thesis examines the role of an essential transcription factor that controls iron uptake responses in the Arabidopsis root. Because iron is an essential nutrient for plant and human nutrition, improvements in our understanding of how plants assimilate iron from the soil will have implications for both agriculture and human health. We report the identification of the transcription factor FIT1 ( Fe-deficiency Induced Transcription factor 1 ), which is required for a proper iron deficiency response. fit1 loss of function plants exhibit severe chlorosis indicative of iron starvation and die at the seedling stage. The ability to rescue this growth phenotype through iron ...
Silicon soil amendment has been shown to enhance plant defenses against insect pests. Rice is a silicon-accumulating graminaceous plant. In the southern United States, the rice water weevil and stem borers are important pests of rice. Current management tactics for these pests rely heavily on the use of insecticides. This study evaluated the effects of silicon amendment when combined with current management tactics for these rice insect pests in the field. Field experiments were conducted from 2013 to 2015. Rice was drill-planted in plots subjected to factorial combinations of variety (conventional and hybrid), chlorantraniliprole seed treatment (treated and untreated), and silicon amendment (treated and untreated). Silicon amendment reduced densities of weevil larvae on a single sampling date in 2014, but did not affect densities of whiteheads caused by stem borers. In contrast, insecticidal seed treatment strongly reduced densities of both weevil larvae and whiteheads. Higher densities of weevil
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Here we use a perturbative approach to compute the ground states of the EN for the joint mapping of two visual features: (i) position in visual space, represented in a retinotopic map and (ii) line orientation, represented in an orientation preference map (OPM). In this framework, the EN incooporates a mapping from a four-dimensional feature space to the twodimensional cortical sheet of neurons. We show that the dynamics of both feature representations can be treated within a general theory for the stability of OPMs [6]. We find various ground states as a function of the lateral intracortical interactions and external stimulus distribution properties. However, in all parameter regimes, the grounds states of the Elastic Network Model are either stripe-like, or crystalline representation of the two visual features. We present a complete phase diagram of the model, summarizing pattern selection. Analytical predictions are confirmed by direct numerical simulations. Our results question previous ...
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這瓶是專門用在眼部的遮瑕, 如果你要遮痘疤就比較不適合可能會嫌不夠力, 它的質地很液狀的非常容易推開, 也不會卡在皺紋裡, 關於遮瑕膏怎麼選色, 亞洲人偏黃的肌膚, 如果你是要蓋在一般的粉底上面, 一般建議是買比自己的粉底淺一兩個色號, 要帶點橘色才能抵掉眼圈裡面的藍黑色, 如果是粉紅色底色的遮瑕膏,通常比較適合很白很白的白種人, 不適合亞洲人的黃肌會造成灰灰的效果, 如果你想要直接使用遮瑕膏不先上粉底的話, 那選擇跟粉底貼近的顏色就可以了, 給大家參考, 大家如果有甚麼心得的話也多多交流 ...
Cyclopiazonic acid (α-cyclopiazonic acid, α-CPA) is an indole-hydrindane-tetramic acid neurotoxin produced by various fungal species, including the notorious food and feed contaminant Aspergillus flavus. Despite its discovery in A. flavus cultures approximately 40 years ago, its contribution to the A. flavus mycotoxin burden is consistently minimized by our focus on the more potent carcinogenic aflatoxins also produced by this fungus. Here, we report the screening and identification of several CPA-type alkaloids not previously found in A. flavus cultures. Our identifications of these CPA-type alkaloids are based on a dereplication strategy involving accurate mass high resolution mass spectrometry data and a careful study of the α-CPA fragmentation pattern. In total, 22 CPA-type alkaloids were identified in extracts from the A. flavus strains examined. Of these metabolites, 13 have been previously reported in other fungi, though this is the first report of their existence in A. flavus. Two of our
Iron (Fe) deficiency chlorosis (IDC) leads to leaf yellowing, stunted growth and drastic yield losses. Plants have been differentiated into Fe-efficient (EF) if they resist to IDC and Fe-inefficient (IN) if they do not, but the reasons for this contrasting efficiency remain elusive. We grew EF and IN soybean plants under Fe deficient and Fe sufficient conditions and evaluated if gene expression and the ability to partition Fe could be related to IDC efficiency. At an early growth stage, Fe-efficiency was associated with higher chlorophyll content, but Fe reductase activity was low under Fe-deficiency for EF and IN plants. The removal of the unifoliate leaves alleviated IDC symptoms, increased shoot:root ratio and trifoliate leaf area. EF plants were able to translocate Fe to the aboveground plant organs, whereas the IN plants accumulated more Fe in the roots. FRO2-like gene expression was low in the roots; IRT1-like expression was higher in the shoots; and ferritin was highly expressed in the roots
Minors.BR page Alwin Pérez played his fifth minor league season in 2008 even though he had just turned 21 during spring training. Pérez was signed by the Kansas City Royals at age 16. He debuted as a pro with the 2004 DSL Royals, hitting .342/.404/.413 with 39 runs in 52 games. In 2005, he batted .283/.415/.361 for the same club, with 43 walks in 55 games and 15 steals in 19 tries. That earned him the honor of Dominican Royals Player of the Year. Alwin came stateside in 2006 and produced at a .281/.363/.365 rate with 19 steals in 24 tries for the AZL Royals. He tied for 4th in the Arizona League in stolen bases and led AZL second basemen in putouts (62) and double plays (26). In 2007, Pérez batted .282/.349/.413 for the Burlington Royals. He played primarily second base still but had 6 outfield assists in 23 games as a flyhawk. In the 2007 Baseball World Cup, the Chitré native was 2 for 4 in 4 games as a utility man for Panama. Unfortunately, his presence on the club cost them a spot in the ...
Do not use this medication without telling your doctor if you are pregnant. Olmesartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.. Do not use potassium supplements or salt substitutes while you are taking amlodipine and olmesartan, unless your doctor has told you to.. Call your doctor at once if you have swelling in your hands or feet, rapid weight gain, fast or pounding heartbeats, jaundice (yellowing of the skin or eyes), chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling, or if you feel like you might pass out.. In rare cases, amlodipine and olmesartan can cause a condition that results in ...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials. ...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials. ...
Read the side effects of Amlodipine and Olmesartan as described in the medical literature. In case of any doubt consult your doctor or pharmacist.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose ...
You are viewing an interactive 3D depiction of the molecule 2-amino-4-hydroxypteridine-6-carboxylic acid (C7H5N5O3) from the PQR.
LUniversité Saint-Esprit de Kaslik (USEK) est une institution catholique privée denseignement supérieur fondée en 1961 par lOrdre Libanais Maronite (OLM).
Zuschriften DOI: 10.1002/ange.201104514 Delivery Platforms Oligonucleotide Delivery by Cell-Penetrating "Striped" Nanoparticles** Christopher M. Jewell, Jin-Mi Jung, Prabhani U. Atukorale, Randy P. Carney, Francesco Stellacci,* and Darrell J. Irvine* Gold nanoparticles (AuNPs) hold great interest in drug delivery because these materials can be functionalized with a range of biological cargos, induce minimal toxicity, and can be efficiently cleared from the body.[1] For example, many studies have described conjugation of DNA or RNA to particle surfaces in well-defined configurations, and these materials have been applied in numerous biological and therapeutic settings.[1, 2] Devising new ways to mediate cell entry by AuNPs is a central area of interest. When mixed self-assembled monolayers of dislike molecules are used to coat AuNPs, nanoscale domains spontaneously form in the particles ligand shell. In particular, "stripe-like" domains form for ca. 1:1 binary mixed ligand compositions.[3] The ...
Regular pattern formation is an intriguing natural phenomenon found in a broad range of ecosystems, such as mussel beds, arid ecosystems, wetland ecosystems, savannahs, coral reefs, ribbon forests, intertidal mudflats and marsh tussocks (see Rietkerk & van de Koppel (2008) for a review). Recent studies point at an important use of spatial patterns as indicators for eminent catastrophic shifts in response to changing conditions, such as climate change (Rietkerk et al. 2004; Kéfi et al. 2007; Solé 2007). However, a systematic mathematical analysis of pattern characteristics is lacking for most ecosystems with regular patterns. We provide a mathematical analysis of the formation of spatial, stripe-like regular patterns in mussel beds occurring on soft sediment (Gascoigne et al. 2005; van de Koppel et al. 2005), and assess their potential use as indicators for the resilience of mussel beds. Using the model proposed by van de Koppel et al. (2005), we present the first systematic analysis of the ...
About the Authors xi. Preface xiii. Acknowledgments xvii. Abbreviations xix. Part I Molecular and Nutritional Basis of Cell Membranes and Lipidomics 1. 1 Membranes for Life and Life for Membranes 3. 1.1 Cell Membranes: The Role of Fatty Acids and the Exclusion of Trans Isomers 3. 1.2 Organization and Homeostasis 11. 1a In Depth: The Formation of a Cell Membrane 16. 1b In Depth: Cholesterol and Membranes 17. 1c In Depth: Lipid Rafts 19. 2 Fatty Acid Families: Metabolism and Nutrition 21. 2.1 Saturated Fatty Acids: Biosynthesis and Dietary Regulation 23. 2.2 Monounsaturated Fatty Acids: The Importance to be cis 28. 2a In Depth: The key Steps of Phospholipid Synthesis 31. 2b In Depth: Biosynthesis of the Double Bond and Desaturase Features 34. 2.3 Polyunsaturated Fatty Acids: The Essentiality for Human Cells 37. Concepts Summary 38. S1 Beware of the Nutritional Label! 38. S2 The Optimal Values of Fatty Acids in Tissues 38. S3 Structural Role of Fatty Acids 40. 3 Essential Fatty Acids 41. 3.1 The ...
Glutamine is the most abundant naturally occurring non-essential amino acid in the body and it can be derived from glutamic acid, another member of the amino acid family. Both glutamine and glutamic acid can be found in protein-rich foods such as red meat, nuts and fish. Different tissues in the body have different requirements for L-Glutamine and the most eager consumers of glutamine are the cells of intestines, whilst muscles are known to be high producers of L-Glutamine.. ...
Livayush is launching two new beauty products- Retino- A Tretinoin Cream USP by the famous Johnson & Johnson Pvt Ltd and A- Ret Gel by Menarini India Pvt. Ltd which features 0.025%, 0.05%, 0.1%, Tretinoin (All-Trans Retinoic Acid). This cream consists of plane wetness creamy base. Tretoin Tretinoin Cream is a derivative of Vitamin A. Ideally, Tretoin was designed to treat acne but dermatologists detected that Tretoin will be also effective in treating signs of ageing - including dark spots, uneven skin tone, wrinkles and sagging. However, Retin A is considered as one of an acids family called retinoids, powerful cream exfoliant. So, it will be better for the skin.. This cream works by affecting the growth and maturation of skin cells. However, it also affects the maturation of blood cells in a certain specific type of cancer. It shall decrease the number and severity of acne pimples and also promote quick healing of pimples that do develop. However, this medicine is considered as best in order ...
Glutamate 5-kinase (G5K) makes the highly unstable product glutamyl 5-phosphate (G5P) in the initial, controlling step of proline/ornithine synthesis, being feedback-inhibited by proline or ornithine, and causing, when defective, clinical hyperammonaemia. We determined two crystal structures of G5K from Escherichia coli, at 2.9 A and 2.5 A resolution, complexed with glutamate and sulphate, or with G5P, sulphate and the proline analogue 5-oxoproline. E. coli G5K presents a novel tetrameric (dimer of dimers) architecture. Each subunit contains a 257 residue AAK domain, typical of acylphosphate-forming enzymes, with characteristic alpha(3)beta(8)alpha(4) sandwich topology. This domain is responsible for catalysis and proline inhibition, and has a crater on the beta sheet C-edge that hosts the active centre and bound 5-oxoproline. Each subunit contains a 93 residue C-terminal PUA domain, typical of RNA-modifying enzymes, which presents the characteristic beta(5)beta(4) sandwich fold and three alpha ...
LONDON -- The shares of AstraZeneca (LSE:AZN) (NYSE:AZN) added 1 pence to 3,302 pence during early London trade this morning after the company said it would spend up to $1.15 billion buying an American developer of treatments for lung disorders.. The FTSE 100 member confirmed it would acquire Pearl Therapeutics for an initial $560 million and would pay up to a further $450 million should certain development and regulatory milestones be achieved.. In addition, up to a further $140 million could be payable based on Pearls future sales.. Pearl, based in California, develops inhaled treatments for respiratory diseases such as chronic bronchitis, emphysema and asthma.. Pascal Soriot, AstraZenecas chief executive, said this morning: ...
The Office of Labor-Management Standards (OLMS) in the U.S. Department of Labor is the Federal agency responsible for administering and enforcing most provisions of the Labor-Management Reporting and Disclosure Act of 1959, as amended (LMRDA).
CCD:CCD00225634. CAS:39828-47-2. MDL:MFCD01547735. MF / MW:C4 H4 N2 O3 / 128.087. 同义词:2-OXO-2,3-DIHYDRO-1H-IMIDAZOLE-4-CARBOXYLIC ACID;2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID;1H-IMIDAZOLE-4-CARBOXYLIC ACID, 2,3-DIHYDRO-2-OXO-;2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLICACID;BESTIPHARMA 543-714;ABLOCK AB-10-1646. ...
Carboxylic Acids - 162 compounds. If you do not see a compound you are looking for please try search by structure or send inquiry for custom synthesis service.. ...
In this worksheet, we will practice to writing and interpreting the names and formulas of carboxylic acids and describing their physical and chemical properties.
Amlodipine - The shape of the patch may be circular, oval, or serpiginous, and it may attain to a size large enongh to cover a good part of the back of the hand.
Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā". ...
Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā". ...
Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā". ...
Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā". ...
Las placas Sirocco son las placas de precipitación de proteínas más avanzadas tecnológicamente del mercado y proporcionan un rendimiento óptimo con menor tiempo de procesamiento tanto automatizado como manual.
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A pharmaceutical composition containing a calcium blocker which is azelnidipine or a pharmacologically acceptable salt thereof and a pharmacologically acceptable alkaline material which is an alkali metal hydroxide, an alkaline earth metal hydroxide, an aluminium hydroxide, an alkali metal carbonate,an alkaline earth metal carbonate, an alkaline earth metal carbonate, an alkali metal hydrogencarbonate, a di-alkali metal phosphate, a di-alkaline earth metal phosphate, a tri-alkali metal phosphate, an alkaline earth metal oxide, aluminium oxide, sn alkali metal silicate, an alkaline earth metal silicate, a silicic acid aluminium complex compound, an aluminum-magnesiym complex compound, or a mixture thereof, wherein the alkaline material is added to an extent such that an aqueous solution or disperson solution of said pharmaceutical composition containing a calcium blocker has pH of at least 8 ...
TY - JOUR UR - http://lib.ugent.be/catalog/pug01:2100766 ID - pug01:2100766 LA - eng TI - Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type additions across α-chloro-N-sulfinylimines PY - 2012 JO - (2012) ORGANIC & BIOMOLECULAR CHEMISTRY SN - 1477-0520 PB - 2012 AU - Callebaut, Gert 002004109623 802000651653 AU - Mangelinckx, Sven LA24 001996036896 AU - Kiss, Lorand AU - Sillanpaa, Reijo AU - Fulop, Ferenc AU - De Kimpe, Norbert AB - The efficient asymmetric synthesis of new chiral gamma-chloro-alpha,beta-diamino acid derivatives via highly diastereoselective Mannich-type reactions of N-(diphenylmethylene) glycine esters across a chiral alpha-chloro-N-p-toluenesulfinylimine was developed. The influence of the base, LDA or LiHMDS, used for the formation of the glycine enolates, was of great importance for the anti-/syn-diastereoselectivity of the Mannich-type reaction. The gamma-chloro-alpha,beta-diamino acid ...
Purpose: The outer limiting membrane (OLM) is considered to play a role in maintaining the structure of the retina through mechanical strength. However, the observation of junction proteins located at the OLM and its barrier permeability properties may suggest that the OLM may be part of the retinal barrier. Material and methods: Normal and diabetic rat, monkey, and human retinas were used to analyze junction proteins at the OLM. Proteome analyses were performed using immunohistochemistry on sections and flat-mounted retinas and western blotting on protein extracts obtained from laser microdissection of the photoreceptor layers. Semi-thin and ultrastructure analyses were also reported. Results: In the rat retina, in the subapical region zonula occludens-1 (ZO-1), junction adhesion molecule (JAM), an atypical protein kinase C, is present and the OLM shows dense labeling of occludin, JAM, and ZO-1. The presence of occludin has been confirmed using western blot analysis of the microdissected OLM region. In
Description. UCI Chem 51C Organic Chemistry (Spring 2012) Lec 08. Organic Chemistry -- The Chemistry of the Carboxylic Acid Family -- View the complete course: http://ocw.uci.edu/courses/chem_51c_organic_chemistry.html Instructor: James S. Nowick, Ph.D. License: Creative Commons BY-NC-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This is the third quarter course in the organic chemistry series. Topics covered include: Fundamental concepts relating to carbon compounds with emphasis on structural theory and the nature of chemical bonding, stereochemistry, reaction mechanisms, and spectroscopic, physical, and chemical properties of the principal classes of carbon compounds. Organic Chemistry 51C is part of OpenChem. http://ocw.uci.edu/collections/open_chemistry.html Recorded on April 26, 2012 Index of Topics: 2:00-Carboxylic Acid Derivatives 5:54-Nomenclature 17:44-Acid Chlorides and Anhydrides 22:28-Boiling Points of Esters Versus Alkanes 26:22-Resonance ...
In this study, we have demonstrated that the pan-HDI LAQ824, by inhibiting IL-10 and increasing the expression of B7.2 and the production of several proinflammatory mediators, induced inflammatory macrophages that effectively activate Ag-specific CD4+ T cells and restore the responsiveness of anergic T cells.. Among the above changes, the most striking effect of LAQ824 was its ability to inhibit the production of the immunosuppressive cytokine IL-10. Such an effect was also displayed by other members of the hydroxamic acid family like LBH589, TSA, and SAHA, but not by the more specific HDI MS-275, which mainly target class I HDACs. The central role of IL-10 in the establishment and maintenance of T cell anergy (34, 35, 42-44) prompted us to further investigate the underlying mechanism(s) by which these particular HDIs inhibit IL-10 production in macrophages.. The dynamic production of pro- and anti-inflammatory mediators at the site of Ag encounter has been shown to shape the initiation, ...
June 25, 2014 - The U.S. Food and Drug Administration (FDA) has completed its safety review and has found no clear evidence of increased cardiovascular risks associated with use of the blood pressure medication olmesartan in diabetic patients. This includes Benicar, Benicar HCT, Azor, Tribenzor and generics.. FDA said that it believes the benefits of olmesartan in patients with high blood pressure continue to outweigh the potential risks.. FDA safety review was prompted by the results of the ROADMAP trial. The ROADMAP (Randomized Olmesartan and Diabetes Microalbuminuria Prevention) clinical trial examined the effects of olmesartan in patients with type 2 diabetes, to see whether olmesartan could delay kidney damage. There was an unexpected finding of increased risk of cardiovascular death in the olmesartan group compared to the group taking a placebo, or sugar pill. However, the risk of non-fatal heart attack was lower in the olmesartan-treated patients. To evaluate these findings, FDA reviewed ...
All published cyclotide solution structures exhibit a similar fold that forces the exposure of a hydrophobic patch to the surface. The homology model shown in Figure 5 suggests that, at least for Z. mays D, if a cystine knot is present then a hydrophobic surface will be exposed to the surface. It can be seen that the hydrophobic residues from loops 2 and 3 form a hydrophobic patch along one face of the molecule, with charged residues and additional hydrophobic residues arranged on the other face, as is the case in the bracelet cyclotides (Felizmenio-Quimio et al., 2001). It can be seen in Figure 6 that, at least for the sequences with typical loop 1 spacing, the conservation of hydrophobic residues suggests that a similar situation could occur for these proteins. The importance of the solvent-exposed hydrophobic patches for the natural function of the cyclotides is not known, but the high degree of sequence similarity between the Poaceae sequences and cyclotides may indicate that they are ...
To compare the efficacy on diastolic blood pressure of 40 mg olmesartan to a combination of 20 mg olmesartan and 12.5 mg hydrochlorothiazide in patients who are not sufficiently responding to treatment with 20 mg olmesartan. [ Time Frame: From week 8 to week 12 ...
OLMESARTAN/HIDROCLOROTIAZIDA SANDOZ aa Comp. recub. con película 40 mg/25 mg,efectos secundarios, efectos adversos, precio (Hidroclorotiazida,Olmesartán medoxomilo) de SANDOZ FARMACEUTICA es indicado para Hipertensión arterial esencial. Incluye indicaciones de OLMESARTAN/HIDROCLOROTIAZIDA SANDOZ y información detallade de Hidroclorotiazida,Olmesartán medoxomilo.
On this page about Olmesartan/Amlodipine 40/10 (Blooms The Chemist) you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information.
The Telegraph reported on some fresh takeover rumors last night, noting new gossip that British drugmaker AstraZeneca ($AZN) is considering a buyout of Lexington, MA-based Cubist Pharmaceuticals (
There have been several noteworthy developments in the drug space recently, which will likely have a material impact on the companies in this sector and the markets they serve. Companies mentioned in this review include Bristol-Myers Squibb (BMY), Eli Lilly & Co. (LLY), Merck & Co. (MRK), Pfizer Inc. (PFE), Valeant Pharmaceuticals International (VRX), Regeneron Pharmaceuticals Inc. (REGN), Sanofi (SNY), and AstraZeneca PLC (AZN).
amlodipine benzenesulfonate chemical properties, What are the chemical properties of amlodipine benzenesulfonate 111470-99-6, What are the physical properties of amlodipine benzenesulfonate ect.
Berdasarkan penelitian baru, pemberian antibiotik Clarithromycin pada pasien yang sebelumnya telah menggunakan obat Penghambat Kanal Kalsium (Calcium-Channel Blocker) sebagai terapi antihipertensi diasosiasikan dengan peningkatan risiko rawat inap akibat gagal ginjal akut, hipotensi dan kematian. Latar belakang dilakukannya penelitian ini adalah karena obat-obat tersebut masih sering diresepkan secara bersamaan meskipun FDA mengharuskan pencantuman peringatan,"serious adverse reactions have been reported in patients taking clarithromycin concomitantly with CYP3A4 substrates, which includes hypotension with calcium-channel blockers metabolized by CYP3A4 (such as verapamil, amlodipine, diltiazem)". Tampaknya masih ada keraguan dokter dan apoteker tentang bahaya interaksi obat tersebut sehingga diperlukan studi baru untuk melihat seberapa besar risiko yang ditimbulkan karena peresepan obat-obat tersebut secara bersamaan. ...
Oxoeicosanoid receptor 1 (OXER1) also known as G-protein coupled receptor 170 (GPR170) is a protein that in humans is encoded by the OXER1 gene located on human chromosome 2p21; it is the principle receptor for the 5-Hydroxyicosatetraenoic acid family of carboxy fatty acid metabolites derived from arachidonic acid. The receptor has also been termed hGPCR48, HGPCR48, and R527 but OXER1 is now its preferred designation. OXER1 is a G protein-coupled receptor (GPCR) that is structurally related to the hydroxy-carboxylic acid (HCA) family of G protein-coupled receptors whose three members are HCA1 (GPR81), HCA2 (Niacin receptor 1), and HCA3 (Niacin receptor 2); OXER1 has 30.3%, 30.7%, and 30.7% amino acid sequence identity with these GPCRs, respectively. It is also related (30.4% amino acid sequence identity) to the recently defined receptor, GPR31, for the hydroxyl-carboxy fatty acid 12-HETE. Orthologs of OXER1 are found in various mammalian species including opossums and several species of fish; ...

2-Azetidinecarboxylic acid2-Azetidinecarboxylic acid

Other names: L-pyrrolidine-2-carboxylic acid * Permanent link for this species. Use this link for bookmarking this species for ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?ID=C2517046&Units=SI&Mask=2

Glentham Life Sciences | GM6054 - 3-Azetidinecarboxylic acid  (36476-78-5)Glentham Life Sciences | GM6054 - 3-Azetidinecarboxylic acid (36476-78-5)

3-Azetidinecarboxylic acid (36476-78-5). Find catalogue prices, chemical data, technical specifications and MSDS documents. ...
more infohttps://www.glentham.com/en/products/product/GM6054/

886510-13-0,1-Azetidinecarboxylicacid, 3-hydroxy-, 9H-fluoren-9-ylmethyl ester886510-13-0,1-Azetidinecarboxylicacid, 3-hydroxy-, 9H-fluoren-9-ylmethyl ester

1-Azetidinecarboxylicacid, 3-hydroxy-, 9H-fluoren-9-ylmethyl ester-21chemnet.com is a leading B2B chemical business platform, ... Synonyms : 3-Hydroxyazetidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester;. Molecular Weight : 295.33. ...
more infohttp://www.21chemnet.com/cas/886510-13-0.html

1-BOC-3-AZETIDINE CARBOXYLIC ACID Manufacturer,Supplier,Exporter1-BOC-3-AZETIDINE CARBOXYLIC ACID Manufacturer,Supplier,Exporter

... supplier and exporter of 1-BOC-3-AZETIDINE CARBOXYLIC ACID at reasonable price. ... 1-BOC-3-AZETIDINE CARBOXYLIC ACID (CAS No.142253-55-2) AL0762 ... 1-BOC-3-AZETIDINE CARBOXYLIC ACID 1-BOC-3-AZETIDINE CARBOXYLIC ...
more infohttp://www.alphachemikaindia.com/1-boc-3-azetidine-carboxylic-acid-2757806.html

WAND Product and Services - Organic AcidsWAND Product and Services - Organic Acids

... acetic acid],2-Azetidinecarboxylic Acid,3,3,3-(Trioxo-1,3,5-triazinetriyl)tri(propionic Acid),3,4-Dimethoxyphthalic Acid, ... butyric Acid,(S)-Piperidine-2-carboxylic Acid,1,1-Ferrocenedicarboxylic Acid,1-Amino-4-bromo-9,10-dioxoanthracene-2-sulfonic ... WAND Categories > Chemicals, Organic>Organic Acids >. The WAND Organic Chemicals taxonomy includes the set of substances, ... 3,3,3-(Trioxo-1,3,5-triazinetriyl)tri(propionic Acid). [Display Results] ...
more infohttps://www.wand.com/core/TypeMenu.aspx?sType=4464204&packid=12&sbreadcrumb=4464204&sInfo=Organic+Acids

Boc-azetidine-3-carboxylic acid, 142253-552, suppliers and manufacturersBoc-azetidine-3-carboxylic acid, 142253-552, suppliers and manufacturers

3-dicarboxylic acid mono-tert-butyl ester; 1-(tert-butoxycarbonyl)-3-azetidinecarboxylic acid ... Synonyms: N-Boc-azetidine-3-carboxylic acid; 1-(tert-butoxycarbonyl)azetidine-3-carboxylic acid; azetidine-1, ... Find manufacturers and suppliers for Boc-azetidine-3-carboxylic acid, 142253-552. ... N-Boc-azetidine-3-carboxylic acid; 1-(tert-butoxycarbonyl)azetidine-3-carboxylic acid; azetidine-1,3-dicarboxylic acid mono- ...
more infohttp://www.rdchemicals.com/chemicals.php?mode=details&mol_id=1156

Combi-BlocksCombi-Blocks

... carboxylic acids, imidazoles, thiazoles, azoles, indoles, oxindoles, pyridines, heterocycles, bormides, fluoro compounds, ... 1-Methyl-3-azetidinecarboxylic acid. Purity: 95%. [875629-26-8], MFCD11520621. © 1997-2019 Combi-Blocks Inc. Phone: 1-858-635- ... 3-(Methylamino)propanoic acid HCl. Purity: 98%. [65845-56-9], MFCD03490507. ST-8874. 3-(Methylamino)propionic acid. Purity: 95% ... 3-(Methylamino)-4-nitrobenzoic acid. Purity: 98%. [214778-10-6], MFCD18826011. ST-1576. 4-(Methylamino)-3-nitrobenzoic acid. ...
more infohttp://www.combi-blocks.com/blocks/CA63.htm

WO1992019593A1 - Novel immunosuppressive compounds 
        - Google PatentsWO1992019593A1 - Novel immunosuppressive compounds - Google Patents

Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods WO2001004091A1 (en) * 1999-07-09. ... Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods US6187784B1 (en) 1998-06-03. 2001-02- ... Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods US6734211B1 (en) 1999-07-09. 2004-05- ... Fatty acids such as oleic acid and its glyceride derivatives find use in the preparation of injectables, as do natural ...
more infohttps://patents.google.com/patent/WO1992019593A1/en

CAS Number, CAS NO. Search, cas no. of chemicals Search,cas number database free -CasNo list - 1,178322-42-4,17791-80-9CAS Number, CAS NO. Search, cas no. of chemicals Search,cas number database free -CasNo list - 1,178322-42-4,17791-80-9

1-Azetidinecarboxylic acid, 3-[4-(aminosulfonyl)-1-piperazinyl]-, 1,1-dimethylethyl ester. C12H24N4O4S. ... Benzoic acid, 4-[4,5-dihydro-3-methyl-5-oxo-4-(2-pyridinylmethylene)-1H-pyrazol-1-yl]-. C17H13N3O3. ... L-Aspartic acid, L-prolyl-L-arginyl-L-cysteinylglycyl-L-valyl-L-prolyl-. C30H50N10O10S. ... Heptanoic acid, 3,4,6-trihydroxy-2-methyl-6-(4-methyl-5-oxo-3-cyclohexen-1-yl)-. C15H24O6. ...
more infohttps://www.lookchem.com/cas/list-1-136.html

CAS Number, CAS NO. Search, cas no. of chemicals Search,cas number database free -CasNo list - 1,169038-39-5,169453-31-0CAS Number, CAS NO. Search, cas no. of chemicals Search,cas number database free -CasNo list - 1,169038-39-5,169453-31-0

Butanoic acid,4-[(4-amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)amino]-4-oxo-. C9H12 N4 O5. ... 2-Azetidinecarboxylicacid, 3-(2-hydroxyethyl)-4-oxo-, (2S-trans)- (9CI). C6H9 N O4. ... Benzeneacetic acid, a-[[1-[[(1,1-dimethylethyl)amino]carbonyl]-2-methylpropyl]amino]-,methyl ester, [R-(R*,R*)]- (9CI). C18H28 ... Hexadecanoic acid,1,1-[(1R)-1-[(phosphonooxy)methyl]-1,2-ethanediyl] ester, sodium salt (1:1). C35H69 O8 P . Na. ...
more infohttps://www.lookchem.com/cas/list-1-1301.html

DK125696A -   Inhibitors of rotamase enzyme activity   - Google PatentsDK125696A - Inhibitors of rotamase enzyme activity - Google Patents

Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods AU5606400A (en) 1999-07-09. 2001-01- ... Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds HU0102935A3 (en) 1998-06-03. 2002-01-28. Gpi Nil ... Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders ... N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres and pharmaceutical compositions ...
more infohttps://patents.google.com/patent/DK125696A/en

Author K. Bláha | Collection of Czechoslovak Chemical CommunicationsAuthor K. Bláha | Collection of Czechoslovak Chemical Communications

Proton magnetic reasonance studies of cyclodipeptides containing pipecolic acid, proline and/or 2-azetidinecarboxylic acid. ... An alternative route to Nα-methylamino acid derivatives: Synthesis and conformation of some Nα-acetyl-Nα-methylamino acid ... Amino acids and peptides. CIII. Infrared spectra and conformations of methylamides of N-acylated amino acids with a hydroxyl ... Amino acids and peptides. LXXXVII. Optical rotatory dispersion of some β-aryl α-amino acids and model compounds. 1968, Vol. 33 ...
more infohttp://cccc.uochb.cas.cz/authors/K_Blaha/

Kuniki Kino - Research Output
     - Waseda UniversityKuniki Kino - Research Output - Waseda University

NRPSs and amide ligases producing homopoly(amino acid)s and homooligo(amino acid)s. Hamano, Y., Arai, T., Ashiuchi, M. & Kino, ... Poly-α-glutamic acid synthesis using a novel catalytic activity of Rimk from Escherichia coli K-12. Kino, K., Arai, T. & ... Effective production of Pro-Gly by mutagenesis of l-amino acid ligase. Kino, H., Nakajima, S., Arai, T. & Kino, K., 2016 Aug 1 ... Structure of RizA, an l-amino-acid ligase from Bacillus subtilis. Kagawa, W., Arai, T., Ishikura, S., Kino, K. & Kurumizaka, H ...
more infohttps://waseda.pure.elsevier.com/en/persons/kuniki-kino/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

Azetidinecarboxylic Acid - pharmacology , Membrane Proteins - metabolism , Prealbumin - chemistry , Protein Structure, Tertiary ... Amino Acid , Secretory Pathway - drug effects , Prealbumin - metabolism , Models, Biological , Ubiquitin-Conjugating Enzymes - ... Amino Acid Sequence , Calcium-Binding Proteins , Mannosidases , Membrane Proteins - genetics , Hexosyltransferases - genetics ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=Author:Momohara,%20Mamiko

Conformationally Restricted Creatine Analogs and Substrate Specificity of Rabbit Muscle Creatine Kinase<...Conformationally Restricted Creatine Analogs and Substrate Specificity of Rabbit Muscle Creatine Kinase<...

2-iminoimidazolidine-4-carboxylic acid (11), and 2-imino-3-methylimidazolidine-4-carboxylic acid (12) did not show detectable ... 2-iminoimidazolidine-4-carboxylic acid (11), and 2-imino-3-methylimidazolidine-4-carboxylic acid (12) did not show detectable ... 2-iminoimidazolidine-4-carboxylic acid (11), and 2-imino-3-methylimidazolidine-4-carboxylic acid (12) did not show detectable ... 2-iminoimidazolidine-4-carboxylic acid (11), and 2-imino-3-methylimidazolidine-4-carboxylic acid (12) did not show detectable ...
more infohttps://einstein.pure.elsevier.com/en/publications/conformationally-restricted-creatine-analogs-and-substrate-specif

KAKEN - Researchers | OKADA Yoshio (60068236)KAKEN - Researchers | OKADA Yoshio (60068236)

Journal Article] Synthesis of endomorphin-2 analogues containing piperidinecarboxylic acid (Pip) and 2-azetidinecarboxylic acid ... receptors of endomorphin and morphiceptin analogs containing conformationally constrained 1-aminocyclolakane-1-carboxylic acids ...
more infohttps://nrid.nii.ac.jp/nrid/1000060068236/

Amadis Chemical Products ListAmadis Chemical Products List

2-Ethoxypyrimidine-5-boronic acid 1003043-55-7 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE 100202-39-9 ...
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388ҳ -       Ʒ|??        Ʒ|      Ʒԭ?? - CAS Ų?ѯ388ҳ - Ʒ|?? Ʒ| Ʒԭ?? - CAS Ų?ѯ

S)-(-)-2-Azetidinecarboxylic acid;. L-2-Azetidinecarboxylic acid. C4H7NO2. ????. Ӧ??. ... Naphthaleneacetic acid ethyl ester. C14H14O2. ????. Ӧ??. 2124-55-2. ????-4-????. Indole-4-carboxylic acid;. 1H-4- ... 4-Amino-3,5-diiodobenzoic acid;. 3,5-Diiodo-4-aminobenzoicacid;. 4-Amino-3,5-diiodobenzoic acid;. NSC 57118. C7H5I2NO2. ????. Ӧ ... Tetrachloroterephthalic acid. C8H2Cl4O4. ????. Ӧ??. 2136-89-2. 2-?????? ױ ;. ???????? ױ 2-Chlorobenzotrichloride;. 1-Chloro-2-( ...
more infohttp://www.ichemistry.cn/chemtool/chemicals.asp?Page=388

Combi-BlocksCombi-Blocks

... carboxylic acids, imidazoles, thiazoles, azoles, indoles, oxindoles, pyridines, heterocycles, bormides, fluoro compounds, ... 2S,3R)-3-Methyl-2-azetidinecarboxylic acid". Purity: 95%. [1932255-43-0], MFCD19226412. ... N-Methyl-l-aspartic acid. Purity: 95%. MFCD00069561. QB-9467. N-Methyl-l-aspartic acid HCl. Purity: 95%. [4226-18-0], ... 2-(Methylamino)-2-phenylacetic acid. Purity: 95%. [74641-60-4], MFCD01318769. QB-8558. 2-(Methylamino)-2-phenylacetic acid HCl ...
more infohttps://www.combi-blocks.com/blocks/AA35.htm

Amadis Chemical Products ListAmadis Chemical Products List

3-[[(phenylmethyl)amino]methyl]-1-azetidinecarboxylic acid tert-butyl ester 177947-98-7 ... trifluoromethanesulfonic acid (4-nitrophenyl) ester 17763-80-3 (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one ... 3-amino-4-(4-methylphenyl)butanoic acid hydrochloride 177839-85-9 8-methyl-3,8-diazabicyclo[3.2.1]octane dihydrochloride 17783- ... acetic acid [(13S)-17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] ester ...
more infohttp://chemmol.com/suppliers/Amadis_Chemical/814/137/

719995-40-1|(S)-3-Amino-3-(3-trifluoromethylphenyl)propionic Acid|MuseChem719995-40-1|(S)-3-Amino-3-(3-trifluoromethylphenyl)propionic Acid|MuseChem

Please inquire us to get a quote for cas 719995-40-1,(S)-3-Amino-3-(3-trifluoromethylphenyl)propionic Acid! ... 2-Azetidinecarboxylicacid,3-(1-methylethyl)-4-oxo-,trans-(9CI). Cat No: M033868 View details ... 3S)-3-amino-3-[3-(trifluoromethyl)phenyl]propanoic acid. InChI:. InChI=1S/C10H10F3NO2/c11-10(12,13)7-3-1-2-6(4-7)8(14)5-9(15)16 ... S)-3-Amino-3-(3-trifluoromethylphenyl)propionic Acid. CAS No. : 719995-40-1 ...
more infohttps://www.musechem.com/product/R038956.html

List of MeSH codes (D02) - WikipediaList of MeSH codes (D02) - Wikipedia

... azetidinecarboxylic acid MeSH D02.241.081.583.400 --- technetium tc 99m diethyl-iminodiacetic acid MeSH D02.241.081.583.450 ... azetidinecarboxylic acid MeSH D02.491.485.400 --- technetium tc 99m diethyl-iminodiacetic acid MeSH D02.491.485.450 --- ... edetic acid MeSH D02.241.081.038.455 --- egtazic acid MeSH D02.241.081.038.581 --- iodoacetic acid MeSH D02.241.081.038.581.400 ... muramic acids MeSH D02.241.081.844.562 --- neuraminic acids MeSH D02.241.081.844.562.668 --- sialic acids MeSH D02.241.081.844. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)

85858-95-3,1-Naphthalenecarboxylicacid, 1,2,3,4-tetrahydro-7-methoxy85858-95-3,1-Naphthalenecarboxylicacid, 1,2,3,4-tetrahydro-7-methoxy

Product Name:1-Azetidinecarboxylicacid, 3-hydroxy-, 9H-fluoren-9-ylmethyl ester. Molecular Formula:C18H17NO3. ... Synonyms : 1-Naphthoicacid, 1,2,3,4-tetrahydro-7-methoxy- (6CI);7-Methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid;. ...
more infohttp://www.21chemnet.com/cas/85858-95-3.html
  • On the other hand, the conformationally restricted creatine analogues N-[2-(4,5-dihydroimidazolyl)]sarcosine (10), 2-iminoimidazolidine-4-carboxylic acid (11), and 2-imino-3-methylimidazolidine-4-carboxylic acid (12) did not show detectable activity either as substrates or as inhibitors. (elsevier.com)