A butyrophenone used in the treatment of PSYCHOSES.
Compounds containing phenyl-1-butanone.
A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.
A physiologically diverse phylum of acidophilic, gram-negative bacteria found in a wide variety of habitats, but particularly abundant in soils and sediments.
A board-certified specialty of VETERINARY MEDICINE, requiring at least four years of special education, training, and practice of veterinary surgery after graduation from veterinary school. In the written, oral, and practical examinations candidates may choose either large or small animal surgery. (From AVMA Directory, 43d ed, p278)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Societies whose membership is limited to pharmacists.
Anti-inflammatory analgesic.
Artificial device such as an externally-worn camera attached to a stimulator on the RETINA, OPTIC NERVE, or VISUAL CORTEX, intended to restore or amplify vision.
A clinical syndrome with intermittent abdominal pain characterized by sudden onset and cessation that is commonly seen in infants. It is usually associated with obstruction of the INTESTINES; of the CYSTIC DUCT; or of the URINARY TRACT.
Individuals with a degree in veterinary medicine that provides them with training and qualifications to treat diseases and injuries of animals.
1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.
Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN.
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
Laws concerned with manufacturing, dispensing, and marketing of drugs.
Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.
Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.
Drugs and their metabolites which are found in the edible tissues and milk of animals after their medication with specific drugs. This term can also apply to drugs found in adipose tissue of humans after drug treatment.
A TETRACYCLINE with a 7-chloro substitution.
The maximum exposure to a biologically active physical or chemical agent that is allowed during an 8-hour period (a workday) in a population of workers, or during a 24-hour period in the general population, which does not appear to cause appreciable harm, whether immediate or delayed for any period, in the target population. (From Lewis Dictionary of Toxicology, 1st ed)
A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Closely congeneric derivatives of the polycyclic naphthacenecarboxamide. (Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1117)
A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.
Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.
Educational institutions for individuals specializing in the field of veterinary medicine.
A drug-induced depression of consciousness during which patients respond purposefully to verbal commands, either alone or accompanied by light tactile stimulation. No interventions are required to maintain a patent airway. (From: American Society of Anesthesiologists Practice Guidelines)
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Drugs administered before an anesthetic to decrease a patient's anxiety and control the effects of that anesthetic.
Use for general articles concerning veterinary medical education.
Tumors or cancer of the THYROID GLAND.
A family of alicyclic hydrocarbons containing an amine group with the general formula R-C6H10NH2.
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
An enzyme that catalyzes the conversion of alpha,alpha-trehalose and water to D-glucose. EC 3.2.1.28.
RESPIRATORY MUSCLE contraction during INHALATION. The work is accomplished in three phases: LUNG COMPLIANCE work, that required to expand the LUNGS against its elastic forces; tissue resistance work, that required to overcome the viscosity of the lung and chest wall structures; and AIRWAY RESISTANCE work, that required to overcome airway resistance during the movement of air into the lungs. Work of breathing does not refer to expiration, which is entirely a passive process caused by elastic recoil of the lung and chest cage. (Guyton, Textbook of Medical Physiology, 8th ed, p406)
A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
An antihyperlipoproteinemic agent and uricosuric agent.
Procedure in which an anesthetic is injected directly into the spinal cord.
A widely used local anesthetic agent.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.

Effects of azaperone on cardiovascular and respiratory functions in the horse. (1/11)

1 The butyrophenone tranquilizer, azaperone, was administered intramuscularly, at dose levels of 0.4 and 0.8 mg/kg, to ponies and its effects on cardiovascular and respiratory functions assessed. 2 Arterial blood pH, CO2 tension (PaCO2) and O2 tension (PaO2) remained relatively constant throughout the course of action of azaperone. 3 Azaperone did not modify plasma protein concentration but venous blood packed cell volume and haemoglobin concentration were reduced by 5 to 10% for at least 4 hours. These changes were probably caused by uptake of erythrocytes into the splenic reservoir. 4 Small increases in heart rate occurred for up to 60 min after administration of the drug, and this was followed by a slight bradycardia in some ponies. 5 Azaperone reduced mean arterial blood pressure (MAP) for at least 4 h, by which time its ataractic action was generally no longer apparent. The hypotension was caused, during the early phase of action at least, by a reduction in peripheral resistance, since cardiac output was increased slightly 20 min after its administration. Possible mechanisms underlying the cardiovascular changes are discussed. 6 In spite of reductions in arterial blood O2 content and MAP produced by azaperone, it is likely that tissue oxygenation was adequate, since arterial blood lactate concentrations were not increased.  (+info)

Responses of the pituitary-adrenal system of the pig to environmental changes and drugs. (2/11)

1 The reactivity of the pituitary-adrenal axis of the young pig was tested for its suitability as a sensitive index for any discomfort that might be experienced under certain conditions of intensive husbandry.2 In a thermoneutral environment, most undisturbed piglets showed only slight variations in the plasma concentrations of adrenocorticotrophic hormone (ACTH) and corticosteroids.3 Stimuli such as exposure to ambient temperatures of +40 degrees C or -5 degrees C were required to cause large rises in the plasma concentrations of ACTH and corticosteroids.4 Apparently milder stimuli, such as change of environment, slight frustration or changes in ambient temperatures between +5 degrees C and +30 degrees C only rarely caused a significant rise in plasma corticosteroids. Thus changes in plasma corticosteroid concentrations are not a sensitive index for the reaction of a piglet to its environment.5 Increases in plasma ACTH concentrations occurred faster than those of the corticosteroids, were larger when expressed as a percentage of the basal values and occurred following relatively small disturbances such as omission of the reward in an operant behaviour test when corticosteroid changes were often not detectable. Thus rises in plasma ACTH might be a useful indication that a given situation is disturbing to a pig. The reaction of plasma ACTH concentrations to chronic irritations as they might occur in intensive husbandry remains to be investigated.6 Azaperone (2 mg/kg i.m.), a drug which is used as a sedative in pigs, caused a rise of about 50% in plasma corticosteroid concentrations. It did not diminish the large steroid output seen when the animals were exposed to high and low ambient temperatures.  (+info)

Enhanced blood pressure and appetite responses to chronic central melanocortin-3/4 receptor blockade in dietary-induced obesity. (3/11)

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Post-farrowing stress management in sows by administration of azaperone: effects on piglets performance. (4/11)

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Influence of infused beta-adrenergic agonists on porcine blood metabolites and catecholamines. (5/11)

Anesthetized pigs were infused sequentially with increased concentrations of beta-adrenergic agonists. At selected times during infusion, blood pressure, heart rate and plasma concentrations of free fatty acids (FFA), glycerol, glucose, lactate, norepinephrine, epinephrine and dopamine were measured. Azaperone, a drug used to calm the pigs before anesthesia, caused hypotension and bradycardia but did not affect plasma metabolites. Infusion of norepinephrine, epinephrine, isoproterenol or clenbuterol produced changes in plasma metabolites and plasma catecholamines. These changes during norepinephrine infusion were attributed to the infused agonist, whereas those during epinephrine infusion might have resulted to some extent from release of norepinephrine. Plasma isoproterenol was not quantified because it interfered with the assay of epinephrine and dopamine so that it was not possible to distinguish between infused isoproterenol and release of endogenous epinephrine and dopamine. Infusion of clenbuterol caused a small increase in plasma norepinephrine so that some of the increase in plasma FFA, glycerol and lactate during clenbuterol infusion may result from release of endogenous norepinephrine.  (+info)

A behavioral pharmacological study of mafoprazine, a new phenylpiperazine derivative. (6/11)

Behavioral pharmacological studies on mafoprazine, a new drug for the prevention of aggressive behavior, were performed to compare its effects with those of an existing drug, azaperone (Stresnil). The acute toxicity of mafoprazine in mice was slightly stronger than that of azaperone. Mafoprazine showed the following effects (at 0.2 to 2.0 mg/kg, s.c.): a decrease in spontaneous motor activity, prolongation of the duration of pentobarbital anesthesia, inhibition of long-term isolation-induced aggressive behavior, inhibition of olfactory bulbectomy-induced hyperemotionality and muricide behavior in mice and rats, and a marked taming and tranquilizing effect on aggressive behavior in dogs. These effects of mafoprazine were qualitatively the same as those of azaperone. Mafoprazine showed cataleptogenicity in rats at 5 mg/kg, s.c. or more and motor incoordination in rats at 0.2 mg/kg, s.c. or more. In the experiment on operant behavior in rats, the effect of mafoprazine on differential reinforcement of the low rate (DRL) response was almost the same as those of azaperone and chlorpromazine. These results indicate that mafoprazine has substantially the same psychotropic effect as azaperone, while the former has a weaker action on the extrapyramidal system than the latter, suggesting that mafoprazine could be used as a unique aggression-inhibiting drug.  (+info)

Effects of amperozide and azaperone on aggression and productivity of growing-finishing pigs. (7/11)

Levels of aggression, activity and performance were determined in 270 pigs (initial wt 29.8 kg) injected with amperozide (1.0 mg/kg i.m.), azaperone (2.2 mg/kg i.m.) or saline (.1 ml/kg i.m.) immediately prior to mixing. Pigs had ad libitum access to feed in pens of 15, and six pens were allotted to each treatment. Each pen was video-taped for 48 h after injection. Aggression was determined by continuous observation and summarized for each 2-h period. Injuries on the ears and shoulders of each pig were scored prior to injection and 1, 2, 3 and 7 d after treatment. Eating, drinking and lying were determined by scan sampling at 2-min intervals and summarized for each 2-h period. Weight gain, feed consumption and efficiency were determined for periods ending on d 3, 7, 14, 28, 42, 56, 70 and 84. Both drugs reduced total fighting from 309.8 min for saline to 190.7 and 189.6 min for amperozide- and azaperone-treated pens, respectively (P less than .01). Treatment differences in aggression and lying were evident during the initial 6 h only. Amperozide resulted in fewer fights involving two pigs (197.3/pen) than did azaperone (260.2/pen) or saline (298.3/pen) (P less than .05). Injuries to the ears (P less than .01) and total injuries (P less than .05) were less severe in amperozide-treated pigs than in pigs on the other treatments.(ABSTRACT TRUNCATED AT 250 WORDS)  (+info)

An analysis of some behavioural effects of the vibration and noise components of transport in pigs. (8/11)

The reactions of pigs to the vibration and noise components of transport were examined with the use of an apparatus which simulated these factors. The pigs were trained to switch off the apparatus by pressing a switch panel with their snouts. It was found that vibration was aversive but that noise was not. The pigs switched off the apparatus more frequently when the vibration was fast and when they had been fed a large meal before the test. Although the sedative tranquillizing drug azaperone decreased the number of times the apparatus was switched off, the effect appeared to be non-specific because azaperone also reduced the number of responses that pigs would make in order to receive food.  (+info)

Literature References: Prepn: Janssen, US 2979508 (1961). Synthesis of labeled compound: Soudijn, van Wijngaarden, J. Lab. Comp. 4, 159 (1968). Distribution and metabolism studies in rat and pig: Heykants et al., Arzneim.-Forsch. 21, 982, 1263, 1357 (1971). Veterinary clinical studies: Symoens, van den Brande, Vet. Rec. 85, 64 (1969). Crystal structure: M. H. J. Koch et al., Acta Crystallogr. 33B, 1975 (1977). ...
Acetorphine is a potent opioid analgesic, up to 8700 times stronger than morphine by weight. It is a derivative of the more well-known opioid etorphine, which is used as a very potent veterinary painkiller and anesthetic medication, primarily for the sedation of large animals such as elephants, giraffes and rhinos. Acetorphine was developed in 1966 by the Reckitt research group that developed etorphine. Acetorphine was developed for the same purpose as etorphine itself, namely as a strong tranquilizer for use in immobilizing large animals in veterinary medicine. Despite showing some advantages over etorphine, for instance producing less toxic side effects in giraffes, acetorphine was never widely adopted for veterinary use, and etorphine (along with other tranquilizers such as carfentanil and azaperone) remains the drug of choice in this application. Acetorphine is a Schedule I controlled substance in the United States. Its DEA Administrative Controlled Substances Control Number is 9319 and the ...
Literature References: Injectable hypnotic related to etomidate, q.v. Prepn: BE 662474; E. F. Godefroi, C. A. M. van der Eijcken, US 3354173 (1965, 1967 both to Janssen); E. F. Godefroi et al., J. Med. Chem. 8, 220 (1965). Anaesthetic effect of combination with azaperone, q.v.: J. F. F. Callear, J. F. E. Van Gestel, Vet. Rec. 92, 284 (1973); of combination with fentanyl, q.v.: W. Erhardt, J. Small Anim. Pract. 19, 401 (1978); C. J. Green, Lab. Anim. 15, 171 (1981). ...
A sampling system includes an input terminal for receiving a data signal having a signal component and possibly a noise component. A sampler samples the data signal at a sample rate set in responsive to a control signal. A noise detector detects the presence of a noise component, and if a noise component is detected, generates the control signal conditioning the sampler to sample the data signal at a first sample rate satisfying the Nyquist criterion for the data signal including the noise component, and otherwise generating the control signal conditioning the sampler to sample the data signal at a second data rate satisfying the Nyquist criterion for the data signal including only the signal component.
janvier 2020. Noise is a fundamental component of confocal images, a result of discreet digital sampling of continuously emitting photons from samples. The contribution of noise to image quality (signal-to-noise ratio) increases as the signal decreases as a square-root function. Using a trained neural network, we use artificial intelligence to remove the shot noise component from confocal image data, allowing an increase in image quality and the ability to acquire dimmer samples at faster rates. NIS-Elements softwares Denoise.ai deploys this trained network for live or post-acquisition processing.. ...
A combination of an ultrasonic scanner and an omnidirectional receive transducer for producing a two-dimensional image from received echoes is described. Two-dimensional images with different noise components can be constructed from the echoes received by additional transducers. These can be combined to produce images with better signal to noise ratios and lateral resolution. Also disclosed is a method based on information content to compensate for the different delays for different paths through intervening tissue is described. The disclosed techniques have broad application in medical imaging but are ideally suited to multi-aperture cardiac imaging using two or more intercostal spaces. Since lateral resolution is determined primarily by the aperture defined by the end elements, it is not necessary to fill the entire aperture with equally spaced elements. Multiple slices using these methods can be combined to form three-dimensional images.
Acoustic Analysis and synthesis of hoarseness by sound spectrography suggests that the acoustic properties of hoarseness are mainly determined by the interactions of the following three factors: 1) noise components in the main formant of each vowel, 2) high frequency noise components above 3000 Hz, and 3) the loss of high frequency harmonic components. These three findings are more pronounced in the vowels /α/, /ε/, and /i/ than in /u/ and /ɔ/. With the progression of the severity of hoarseness, these three abnormal patterns become more prominent and exaggerated. On the basis of these findings, a classification of four types of hoarseness was presented using sonagram tracings.. ...
Exporter of Veterinary Drugs - Nimesulide, Pitofenone HCL & Fenpiverinium Bromide Injection, Haloperidol Decanoate Injection 20 mg, Azaperone Injection 40 mg/ml and Xylazine Injection offered by Livealth Biopharma Private Limited, Navi Mumbai, Maharashtra.
CASE#5 WILDEBEAST RELOCATION. Date: 23rd January 2015. Species: Wildebeest (Connochaetes taurinus). Sex: Male. Age: Adult. Location: Olkinyei (PCEA Acacia Missionaries Compound). History. This wildebeest was rescued a few years ago after his mother was allegedly killed by locals. He grew up within the missionaries compound enjoying the security and company of the residents. Though other wildebeests are seen nearby and he has been known to join them on occasion, he always returns to the compound due to his habituation. At three years old, this wildebeest had started to become aggressive and dangerous. As a result, KWS management, in consultation with the county administration, decided it should be relocated to the wild, far from the compound to any conservancy with a population of wildebeests.. Capture and release. The wildebeest was immobilized by use of a combination of 5mgs Etorphine and 50mgs Azaperone in a 3ml Dan Inject dart, which was done from foot. The drugs took effect after five ...
Fourier transform mass spectrometry (FTMS) enables comprehensive analysis of complex molecular mixtures. Given the broad intensity ranges of components in the mass spectra, it is imperative to accurately determine a noise threshold level above which peak assignments will be made. Conventionally, to find the threshold level, the N sigma approach or an equivalent rule is used. However, the N sigma approach cannot be applied to mass spectra stored with partially removed noise (reduced-profile mode). It is also not directly applicable to mass spectra acquired in the absorption mode with removed negative spectral amplitudes. Moreover, N value selection is normally made based on a rule of thumb, meaning that the calculated threshold level may be biased. Here, we present a noise thresholding method which addresses these limitations for analysis of mass spectra of complex molecular mixtures. The introduced data-dependent thresholding method involves analysis of the distribution of logarithmic ...
The technology used in hybrid vehicle concepts is significantly different from conventional vehicle technology with consequences also for the noise and vibration behavior. In conventional vehicles, certain noise phenomena are masked by the engine noise. In situations where the combustion engine is turned off in hybrid vehicle concepts, these noise components can become dominant and annoying. In hybrid concepts, the driving condition is often decoupled from the operation state of the combustion engine, which leads to unusual and unexpected acoustical behavior. New acoustic phenomena such as magnetic noise due to recuperation occur, caused by new components and driving conditions. The analysis of this recuperation noise by means of interior noise simulation shows, that it is not only induced by the powertrain radiation but also by the noise path via the powertrain mounts. The additional degrees of freedom of the hybrid drive train can also be used to improve the vibrational behavior ...
The technology used in hybrid vehicle concepts is significantly different from conventional vehicle technology with consequences also for the noise and vibration behavior. In conventional vehicles, certain noise phenomena are masked by the engine noise. In situations where the combustion engine is turned off in hybrid vehicle concepts, these noise components can become dominant and annoying. In hybrid concepts, the driving condition is often decoupled from the operation state of the combustion engine, which leads to unusual and unexpected acoustical behavior. New acoustic phenomena such as magnetic noise due to recuperation occur, caused by new components and driving conditions. The analysis of this recuperation noise by means of interior noise simulation shows, that it is not only induced by the powertrain radiation but also by the noise path via the powertrain mounts. The additional degrees of freedom of the hybrid drive train can also be used to improve the vibrational behavior ...
Background Although microarrays are analysis tools in biomedical research, they are known to yield noisy output that usually requires experimental confirmation. To tackle this problem, many studies have developed rules for optimizing probe design and devised complex statistical tools to analyze the output. However, less emphasis has been placed on systematically identifying the noise component as part of the experimental procedure. One source of noise is the variance in probe binding, which can be assessed by replicating array probes. The second source is poor probe performance, which can be assessed by calibrating the array based on a dilution series of target molecules. Using model experiments for copy number variation and gene expression measurements, we investigate here a revised design for microarray experiments that addresses both of these sources of variance. Results Two custom arrays were used to evaluate the revised design: one based on 25 mer probes from an Affymetrix design and the other
Provided is a test apparatus that tests a device under test, comprising a waveform generator that generates a test signal to be supplied to the device under test; a digitizer that measures a response signal output by the device under test; a judging section that judges acceptability of the device under test based on the measurement result of the digitizer; and a loop-back path that connects an output terminal of the waveform generator to an input terminal of the digitizer when calibration is performed for the waveform generator and the digitizer. The loop-back path includes a noise removal filter that eliminates a noise component from a signal passed therethrough; and a path switching section that connects the waveform generator to the digitizer via the noise removal filter when the digitizer is being calibrated, and connects the waveform generator to the digitizer without including the noise removal filter therebetween when the waveform generator is
If youre due to travel to a place where malaria is present, you should delay trying for a baby while youre taking anti-malaria medication.. Women of childbearing age are advised to use contraception to avoid becoming pregnant in countries that have malaria. This is because pregnant women have an increased risk of developing severe malaria and a higher risk of fatality compared with non-pregnant women.. The risk to pregnant women is increased even when taking malaria pills because:. ...
TY - JOUR. T1 - Pulmonary dead space in free-ranging immobilized black rhinoceroses (Diceros Bicornis) in Namibia. AU - Radcliffe, Robin W.. AU - Morkel, Peter. AU - Jago, Mark. AU - Taft, Arthur A.. AU - Du Preez, Pierre. AU - Miller, Michele A.. AU - Candra, Dedi. AU - Nydam, Daryl V.. AU - Barry, Jason S.. AU - Gleed, Robin D.. PY - 2014/6. Y1 - 2014/6. N2 - It was observed previously that end-expired carbon dioxide (PÉCO2) decreased when immobilized black rhinoceroses (Diceros bicornis) were moved from sternal to lateral recumbency. These experiments were designed to test whether greater alveolar ventilation or greater pulmonary dead space in lateral recumbency explains this postural difference in PÉCO2. Twenty-one (9 male, 12 female; 15 3.5-26 yr old) wild black rhinoceroses were immobilized with etorphine and azaperone and positioned in either sternal or lateral recumbency. All rhinoceroses were hypoxemic and had lactic and respiratory acidemia. The animals in lateral recumbency were ...
Based on some reading Ive been doing, how or when you eat certain foods plays a big role in whether or not its digested properly. The two books that come to mind are Healing with Whole Foods by Paul Pitchford and Never Be Sick Again by Raymond Francis, where both authors dedicate a section on the importance of food combinations. They both start by classifying foods by which the environment they require within the stomach for proper digestion, acidic or alkaline, as well what foods can (or should) be combined in order to achieve this. They go on to explain how the stomach can accommodate either environment, be it acidic for the proteins or alkaline for the starches, but not at the same time; fruits being the exception since they are meant to travel quickly through the digestive system. Both authors lay down the same foundation vegetables with proteins ok, vegetables with starches ok, eat fruits alone, with a few special cases noted, but differ slightly in their approach; Raymond Francis ...
An important image post-processing step for optical coherence tomography (OCT) images is speckle noise reduction. Noise in OCT images is multiplicative in nature and is difficult to suppress due to the fact that in addition the noise component, OCT speckle also carries structural information about the imaged object. To address this issue, a novel speckle noise reduction algorithm was developed. The algorithm projects the imaging data into the logarithmic space and a general Bayesian least squares estimate of the noise-free data is found using a conditional posterior sampling approach. The proposed algorithm was tested on a number of rodent (rat) retina images acquired in-vivo with an ultrahigh resolution OCT system. The performance of the algorithm was compared to that of the state-of-the-art algorithms currently available for speckle denoising, such as the adaptive median, maximum a posteriori (MAP) estimation, linear least squares estimation, anisotropic diffusion and wavelet-domain filtering ...
Summer infertility in free range pigs. How day length, temperature and breed impact on piglet numbers in after summer. PROOF Pasture Raised on Open Fields.
Forty-eight castrated F-2 offspring of Pietrain and Large White pigs were allocated to a 3 x 2 factorial design in order to study the interactive effect of halothane genotype (NN, Nn and nn) and pre-slaughter treatment [referred to as Experimental (EXP) and Commercial-like (COL) conditions; the latter combining short transportation, mixing unfamiliar pigs and slaughtering shortly after transport] on muscle post mortem changes and meat quality. The pigs were slaughtered over 4 days. Pre-slaughter glycogen depletion in M. longissimus lumborum (LL) was greater in the nn pigs, compared with the two other genotypes. Lactate accumulation post mortem in LL muscle was greater and the pH value at 40 min post mortem was lower in nn compared with NN pigs. Nit pigs were close to nn pigs for lactate accumulation and showed intermediate pH values in the LL muscle. In the M. semimembranosus (SM), NN and Nn pigs showed the same rate of post mortem changes, as evidenced by similar glycogen, lactate, creatine
Objective voice analysis is of profound importance for daily phoniatric practices, for diagnostics and the therapy of dysphonia both. The Göttingen Hoarseness-diagram (GHD) is considered to be the ultimate benchmark. It requires recording 28 vocals by qualified personnel in ca. 15 minutes time. This study investigates wether the GHD is able to produce valid results for voice quality if, instead of standard protocol, phonations recorded during laryngoscopy and stroboscopy are analyzed (so-called reduced protocol). If this was possible, voice analysis and examination of the larynx could be performed simultaneously thus leading to a reduced expenditure of time and personnel. For this thesis, voice recordings taken during the stroboscopy and laryngoscopy of 213 patients (97 male, 116 female) were analyzed with the GHD. On the same day phonations following the complete GHD-protocol were also recorded and analyzed. The GHD measures the voice´s irregularity and noise component and the results for ...
Rats were induced to drink either a saline-etonitazene solution or a saline solution with a schedule-induced polydipsia paradigm. When water was freely available, the rats continued to drink the saline solution or the saline-etonitazene solution, rather than the water. When the locations of the solutions were switched, the rats that were drinking saline switched to water (drank at the usual location), but the rats that were drinking saline-etonitazene continued to drink the saline-etonitazene solution (drank from the bottle at the other location). Naloxone administration temporarily eliminated the drinking of saline-etonitazene solution, but not that of saline solution. ...
TY - JOUR. T1 - Comparison of the anterior pituitary-adrenal cortical stimulating effect of U.S.P. epinephrine, synthetic L-epinephrine, and nor-epinephrine.. AU - MADISON, L. L.. PY - 1950/6. Y1 - 1950/6. UR - http://www.scopus.com/inward/record.url?scp=38049176743&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=38049176743&partnerID=8YFLogxK. U2 - 10.1172/JCI102316. DO - 10.1172/JCI102316. M3 - Article. C2 - 15436670. AN - SCOPUS:38049176743. VL - 29. SP - 789. EP - 791. JO - Journal of Clinical Investigation. JF - Journal of Clinical Investigation. SN - 0021-9738. IS - 6. ER - ...
Azaperone • Benperidol • Bromperidol • Clopenthixol • Chlorpromazine • Chlorprothixene • Droperidol • Flupentixol • ...
QN01AX91 Azaperone. QN01AX92 Benzocaine. QN01AX93 Tricaine mesilate. QN01AX99 Other general anesthetics, combinations. N01B 국소 ...
QN05AD90 Azaperone. N05AE 인돌 계열[편집]. N05AE01 Oxypertine. N05AE02 Molindone. N05AE03 Sertindole. N05AE04 Ziprasidone. N05AF 치옥산텐 ...
A few pyridinylpiperazine derivatives are drugs, including: Azaperone - antipsychotic Atevirdine - antiretroviral Delavirdine ...
... along with other tranquilizers such as carfentanil and azaperone) remains the drug of choice in this application. Acetorphine ...
... combinations QN01AX91 Azaperone QN01AX92 Benzocaine QN01AX93 Tricaine mesilate QN01AX94 Isoeugenol QN01AX99 Other general ...
... azaperone (INN) azaprocin (INN) azapropazone (INN) azaquinzole (INN) azaribine (INN) Azasan azaserine (INN) azasetron (INN) ...
Moperone N05AD05 Pipamperone N05AD06 Bromperidol N05AD07 Benperidol N05AD08 Droperidol N05AD09 Fluanisone QN05AD90 Azaperone ...
These include: Azaperone Combelen (Bayer) Domosedan (Farmos) Dormicum (midazolam) (Roche) Detomidine (Farmos) Fentanyl and ...
The European Medicines Agency has established a maximum residue limit for azaperone when administered to pigs. Azaperone (under ... Azaperone may cause hypotension and while it has minimal effects on respiration in pigs, high doses in humans can cause ... Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with ... Azaperone is also used in combination with strong narcotics such as etorphine or carfentanil for tranquilizing large animals ...
... (INN) (brand name Nopron) is a sedative-hypnotic drug of the phenylpiperazine group.[1][2] It has been used in the treatment of sleep disturbances since the early 1970s in several European countries including France, Italy, and Luxembourg.[3][4] It is commonly used with children and adolescents on account of its favorable safety and tolerability profile and lack of abuse potential.[5][6][7][8][9][10] Originally believed to act as an antihistamine and anticholinergic,[11] niaprazine was later discovered to have low or no binding affinity for the H1 and mACh receptors (Ki = , 1 μM), and was instead found to act as a potent and selective 5-HT2A and α1-adrenergic receptor antagonist (Ki = 75 nM and 86 nM, respectively).[12] It possesses low or no affinity for the 5-HT1A, 5-HT2B, D2, and β-adrenergic, as well as at SERT and VMAT (Ki = all , 1 μM), but it does have some affinity for the α2-adrenergic receptor (Ki = 730 nM),[12] likely acting as an antagonist there as well. Niaprazine ...
... causes arterial/arteriolar vasodilation leading to a decrease in blood pressure by activating peripheral D1 receptors.[5] It decreases afterload and also promotes sodium excretion via specific dopamine receptors along the nephron. The renal effect of fenoldopam and dopamine may involve physiological antagonism of the renin-angiotensin system in the kidney.[6] In contrast to dopamine, fenoldopam is a selective D1 receptor agonist with no effect on beta adrenoceptors, although there is evidence that it may have some alpha-1 [7] and alpha-2 adrenoceptor antagonist activity.[5] D1 receptor stimulation activates adenylyl cyclase and raises intracellular cyclic AMP, resulting in vasodilation of most arterial beds, including renal, mesenteric, and coronary arteries.[8] to cause a reduction in systemic vascular resistance. Fenoldopam has a rapid onset of action (4 minutes) and short duration of action (, 10 minutes) and a linear dose-response relationship at usual clinical doses.[9] ...
... (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. The structure is related to diphenhydramine.[1] A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.[1] In addition to its actions as an antihistamine, captodiamine has been found to act as a 5-HT2C receptor antagonist and σ1 receptor and D3 receptor agonist.[2] It produces antidepressant-like effects in rats.[2] However, captodiamine is unique among antidepressant-like drugs in that it increases brain-derived neurotrophic factor (BDNF) levels in the hypothalamus but not in the frontal cortex or hippocampus.[2] This unique action may be related to its ability to attenuate stress-induced anhedonia and corticotropin-releasing factor (CRF) signaling in the hypothalamus.[2] ...
The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...
InChI=1S/C18H22F2N4O/c19-15-5-3-14(4-6-15)17(25)2-1-7-23-8-10-24(11-9-23)18-21-12-16(20)13-22-18/h3-6,12-13,17,25H,1-2,7-11H2 ...
Djaldetti Ruth; Giladi Nir; Hassin-Baer Sharon; Shabtai Hertzel; Melamed Eldad (November-December 2003). "Pharmacokinetics of Etilevodopa Compared to Levodopa in Patient's With Parkinson's Disease: An Open-label, Randomized, Crossover Study". Clinical Neuropharmacology. 26 (6): 322-326. doi:10.1097/00002826-200311000-00012. PMID 14646613 ...
Classen K, Göthert M, Schlicker E (June 1984). "Effects of DU 24565 (6-nitroquipazine) on serotoninergic and noradrenergic neurones of the rat brain and comparison with the effects of quipazine". Naunyn-Schmiedeberg's Archives of Pharmacology. 326 (3): 198-202. doi:10.1007/bf00505318. PMID 6206407 ...
... has also been found to increase the analgesic effects of opioid drugs in a dose-dependent manner, in contrast to 5-HT1A agonists such as 8-OH-DPAT which were found to reduce opioid analgesia.[22][23] However, since 5-HT1A agonists were also found to reduce opioid-induced respiratory depression and WAY-100635 was found to block this effect,[24] it is likely that 5-HT1A antagonists might worsen this side effect of opioids. Paradoxically, chronic administration of the very high efficacy 5-HT1A agonist befiradol results in potent analgesia following an initial period of hyperalgesia, an effect most likely linked to desensitisation and/or downregulation of 5-HT1A receptors (i.e. analogous to a 5-HT1A antagonist-like effect).[25][26][27] As with other 5-HT1A silent antagonists such as UH-301 and robalzotan, WAY 100635 can also induce a head-twitch response in rodents.[28] ...
The combination of BZP and TFMPP has been associated with a range of side effects, including insomnia, anxiety, nausea and vomiting, headaches and muscle aches which may resemble migraine, seizures, impotence, and rarely psychosis,[3] as well as a prolonged and unpleasant hangover effect. These side effects tend to be significantly worsened when the BZP/TFMPP mix is consumed alongside alcohol, especially the headache, nausea, and hangover. However, it is difficult to say how many of these side effects are produced by TFMPP itself, as it has rarely been marketed without BZP also being present, and all of the side effects mentioned are also produced by BZP (which has been sold as a single drug). Studies into other related piperazine drugs such as mCPP suggest that certain side effects such as anxiety, headache and nausea are common to all drugs of this class, and pills containing TFMPP are reported by users to produce comparatively more severe hangover effects than those containing only BZP. The ...
Abou-Gharbia MA, Childers WE, Fletcher H, et al. (December 1999). "Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents". Journal of Medicinal Chemistry. 42 (25): 5077-94. doi:10.1021/jm9806704. PMID 10602693 ...
Novartis fought a seven-year, controversial battle to patent Gleevec in India, and took the case all the way to the Indian Supreme Court. The patent application at the center of the case was filed by Novartis in India in 1998, after India had agreed to enter the World Trade Organization and to abide by worldwide intellectual property standards under the TRIPS agreement. As part of this agreement, India made changes to its patent law, the biggest of which was that prior to these changes, patents on products were not allowed, while afterwards they were, albeit with restrictions. These changes came into effect in 2005, so Novartis' patent application waited in a "mailbox" with others until then, under procedures that India instituted to manage the transition. India also passed certain amendments to its patent law in 2005, just before the laws came into effect.[62][63] The patent application[50][64] claimed the final form of Gleevec (the beta crystalline form of imatinib mesylate).[65]:3 In 1993, ...
Melis MR, Succu S, Sanna F, Melis T, Mascia MS, Enguehard-Gueiffier C, Hubner H, Gmeiner P, Gueiffier A, Argiolas A (October 2006). "PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain". The European Journal of Neuroscience. 24 (7): 2021-30. doi:10.1111/j.1460-9568.2006.05043.x. PMID 17067298 ...
The present meta-analysis was conducted to estimate the magnitude of the effects of methylphenidate and amphetamine on cognitive functions central to academic and occupational functioning, including inhibitory control, working memory, short-term episodic memory, and delayed episodic memory. In addition, we examined the evidence for publication bias. Forty-eight studies (total of 1,409 participants) were included in the analyses. We found evidence for small but significant stimulant enhancement effects on inhibitory control and short-term episodic memory. Small effects on working memory reached significance, based on one of our two analytical approaches. Effects on delayed episodic memory were medium in size. However, because the effects on long-term and working memory were qualified by evidence for publication bias, we conclude that the effect of amphetamine and methylphenidate on the examined facets of healthy cognition is probably modest overall. In some situations, a small advantage may be ...
Most frequent side effects are nausea, orthostatic hypotension, headaches, and vomiting through stimulation of the brainstem vomiting centre.[9] Vasospasms with serious consequences such as myocardial infarction and stroke that have been reported in connection with the puerperium, appear to be extremely rare events.[10] Peripheral vasospasm (of the fingers or toes) can cause Raynaud's Phenomenon. Bromocriptine use has been anecdotally associated with causing or worsening psychotic symptoms (its mechanism is in opposition of most antipsychotics, whose mechanisms generally block dopamine).[11] Pulmonary fibrosis has been reported when bromocriptine was used in high doses for the treatment of Parkinson's disease.[12] Use to suppress milk production after childbirth was reviewed in 2014 and it was concluded that in this context a causal association with serious cardiovascular, neurological or psychiatric events could not be excluded with an overall incidence rate estimated to range between 0.005% ...
Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A (1997). "S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity". J Pharmacol Exp Ther. 282 (1): 132-147. PMID 9223549 ...
... (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine. The drug's name is derived from the methylsulfoxy and piperidine functional groups in its chemical structure. It has central antiadrenergic, antidopaminergic, antiserotonergic and weak muscarinic anticholinergic effects. Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome. Mesoridazine was withdrawn from the United States market in 2004 due to dangerous side effects, namely irregular heart beat and QT-prolongation of the electrocardiogram.[1] It currently appears to be unavailable worldwide. ...
InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1 ...
... (MDPPP) is a stimulant designer drug. It was sold in Germany in the late 1990s and early 2000s as an ingredient in imitation ecstasy (MDMA) pills.[1] It shares a similar chemical structure with α-PPP and MDPV,[2][3][4] and has been shown to have reinforcing effects in rats.[5] ...
... is used to treat a wide variety of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid.[2]. Ciprofloxacin only treats bacterial infections; it does not treat viral infections such as the common cold. For certain uses including acute sinusitis, lower respiratory tract infections and uncomplicated gonorrhea, ciprofloxacin is not considered a first-line agent.. Ciprofloxacin occupies an important role in treatment guidelines issued by major medical societies for the treatment of serious infections, especially those likely to be caused by Gram-negative bacteria, including Pseudomonas aeruginosa. For example, ciprofloxacin in combination with metronidazole is one of several first-line antibiotic regimens recommended by the Infectious Diseases Society of America for the treatment of community-acquired abdominal infections in ...
Brand names include Eskazinyl, Eskazine, Jatroneural, Modalina, Stelazine, Terfluzine, Trifluoperaz, Triftazin. In the United Kingdom and some other countries, trifluoperazine is sold and marketed under the brand 'Stelazine'. The drug is sold as tablet, liquid and 'Trifluoperazine-injectable USP' for deep intramuscular short-term use. GP studying pharmacological data has indicated cases of neck vertebrae irreversible fusing leading to NHS preparations being predominantly of the liquid form trifluoperazine as opposed to the tablet form as in Stela zine etc. In the past, trifluoperazine was used in fixed combinations with the MAO inhibitor (antidepressant) tranylcypromine (tranylcypromine/trifluoperazine) to attenuate the strong stimulating effects of this antidepressant. This combination was sold under the brand name Jatrosom N. Likewise a combination with amobarbital (potent sedative/hypnotic agent) for the amelioration of psychoneurosis and insomnia existed under the brand name Jalonac. In ...
A list of US medications equivalent to Azaperone is available on the Drugs.com website. ... Azaperone is a medicine available in a number of countries worldwide. ... Fentazin 5 (Azaperone and Fentanyl, + Xylazine (veterinary use)). Bayer New Zealand, New Zealand ... Azaperone. In some countries, this medicine may only be approved for veterinary use. ...
Other names: 1-Butanone, 1-(4-fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-; Butyrophenone, 4-fluoro-4-[4-(2-pyridyl)-1-piperazinyl]-; Fluoperidol; R-1929; Stresnil; Suicalm; Azeperone; Eucalmyl; Sedaperone vet; 4-Fluoro-4-(4-(2-pyridyl)-1-piperazinyl)butyrophenone; 1-(3-(4-Fluorobenzoyl)propyl)-4-(2-pyridyl)piperazine; 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone; 4-Fluoro-4-[4-(2-pyridinyl)-1-piperazinyl]butyrophenone; NSC 170976; 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone (azaperone ...
The European Medicines Agency has established a maximum residue limit for azaperone when administered to pigs. Azaperone (under ... Azaperone may cause hypotension and while it has minimal effects on respiration in pigs, high doses in humans can cause ... Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with ... Azaperone is also used in combination with strong narcotics such as etorphine or carfentanil for tranquilizing large animals ...
See Also: Toxicological Abbreviations Azaperone (WHO Food Additives Series 29) Azaperone (WHO Food Additives Series 34) ... Studies were conducted to evaluate the effects of azaperone on reproduction and fertility in male rats. Azaperone was ... mutagenic potential of azaperone and its metabolites. To support this statement, the biotransformation of azaperone was studied ... Azaperone, however, is a relatively weak prolactin-releasing agent in rats, stimulating the mammary gland at doses , 40 mg/kg ...
Buy Azaperone Assay Standard - CAS Number 1649-18-9 from LGC Standards. Please login or register to view prices, check ... Fluoperidol ; Stresnil ; 1-Butanone, 1-(4-fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]- ; R-1929 ;Azaperone ; NSC 170976 ; 4 ... Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone ; Suicalm ; Azaperone ; 1-(4-Fluorophenyl)-4-[4-(pyridin-2-yl)piperazin-1- ...
Literature References: Prepn: Janssen, US 2979508 (1961). Synthesis of labeled compound: Soudijn, van Wijngaarden, J. Lab. Comp. 4, 159 (1968). Distribution and metabolism studies in rat and pig: Heykants et al., Arzneim.-Forsch. 21, 982, 1263, 1357 (1971). Veterinary clinical studies: Symoens, van den Brande, Vet. Rec. 85, 64 (1969). Crystal structure: M. H. J. Koch et al., Acta Crystallogr. 33B, 1975 (1977). ...
Azaperone. *Buspirone (Buspar). Are anti-anxiety drugs safe to use for treating my medical condition if I am pregnant or ...
The major metabolite of azaperone is azaperol. For control purposes the marker... ... Azaperone can be used as tranquilizer to prevent stress during transportation of pigs. ... Azaperone can be used as tranquilizer to prevent stress during transportation of pigs. The major metabolite of azaperone is ... Azaperone can be used as tranquilizer to prevent stress during transportation of pigs. The major metabolite of azaperone is ...
Azaperone , , , ,,, , , , ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and ... Azaperone Benperidol Bromperidol Droperidol Fluanisone Haloperidol # Lenperone Moperone Pipamperone Spiperone Timiperone ... Azaperone (Stresnil, Fluoperidol) is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic ... Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with ...
556.68 Azaperone.. (a) Acceptable daily intake (ADI). The ADI for total residue of azaperone is 0.63 µg/kg of body weight per ... 556.68 Azaperone.. §556.70 Bacitracin.. §556.75 Bambermycins.. §556.100 Carbadox.. §556.110 Carbomycin.. §556.113 Ceftiofur.. § ...
Pharmaceutical Raw Powder Azaperone CAS 1649-18-9 FOB Price: $1 - $3 / Piece Min. Order: 10 Pieces ...
77 FR 46612 - New Animal Drugs; Change of Sponsor; Change of Sponsor Address; Azaperone; Miconazole, Polymyxin B, and ...
77 FR 46612 - New Animal Drugs; Change of Sponsor; Change of Sponsor Address; Azaperone; Miconazole, Polymyxin B, and ...
China Made Azaperone Powder Pharmaceutical Chemicals CAS 1649-18-9 FOB Price: $10 - $100 / g Min. Order: 1 g ...
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556.68 Azaperone. (a) Acceptable daily intake (ADI). The ADI for total residue of azaperone is 0.63 [micro]g/kg of body weight ...
Seventeen captive Nubian ibex (Capra nubiana) were immobilized for transportation and/or hoof trimming, deworming, and vaccinations. Of these, 11 were immobilized with a combination of butorphanol (0.13±0.03
Azaperone • Benperidol • Bromperidol • Clopenthixol • Chlorpromazine • Chlorprothixene • Droperidol • Flupentixol • ...
azaperone (6.7; 7.1 µg/kg - ppb) unauthorised in chilled beef from Argentina meat and meat products (other than poultry) food ...
1. Azaperone. 2. Haloperidol. Long acting. 1. Zuclopenthixol. 2. Perphenazine. 3. Pipothiazine palmtate ...
Pharmacodynamics - azaperone Peak sedation in 15-30 mins (IM). Sedation duration 2-3 hours. Decrease HR, CO, ABP. Impaired ...
QN01AX91 Azaperone. QN01AX92 Benzocaine. QN01AX93 Tricaine mesilate. QN01AX99 Other general anesthetics, combinations. N01B 국소 ...
The Kb values were (nanomolar):spiperone, 0.8; spirilene , 2.1; benperidol , 4.4; azaperone, 16.6; and haloperidol, 96.6. The ...
QN05AD90 Azaperone. N05AE 인돌 계열[편집]. N05AE01 Oxypertine. N05AE02 Molindone. N05AE03 Sertindole. N05AE04 Ziprasidone. N05AF 치옥산텐 ...
Azaperone. The risk or severity of adverse effects can be increased when Cinchocaine is combined with Azaperone.. ...
Azaperone. Stugeron. Cinnarizine. Stugeron Forte. Cinnarizine. Stugeron Retard. Cinnarizine. Stugil. Cinnarizine; Domperidone ...
azaperone (Stresnil ). * benperidol (Anquil ). * droperidol (Inapsine ). * fluspirilene (effective for 1 week). * haloperidol ( ...
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Sedate with azaperone (Stresnil) and examine. *Provide a dry, well bedded, well drained pen. ...
Azaperone Forensic ELISA Kit. Azaperone ELISA is a screening test kit for the detection of drugs and/or their metabolites in ... Azaperone Racing ELISA Kit. Azaperone ELISA is a screening test kit for the detection of drugs and/or their metabolites in ...
  • The argument was reinforced by the lack of genotoxicity for azaperone and other butyrophenones, including haloperidol, pimozide, bromperidol, and bromperidol decanoate. (inchem.org)
  • Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with similar drugs such as haloperidol. (wikipedia.org)
  • Notably, synthesis of the -difluoroalkene analogues of azaperone, haloperidol, and benperidol was also accomplished u. (bioportfolio.com)
  • Our range of products include nimesulide, pitofenone hcl & fenpiverinium bromide injection, haloperidol decanoate injection 20 mg, azaperone injection 40 mg/ml, xylazine injection, ivermectin & praziqantel oral paste and fipronil 0.25% wv 100ml spray. (livealthbiopharma.co.in)
  • Azaperone (under the brand name Stresnil) was approved for use in pigs in the USA in 1983, under NADA 115-732. (wikipedia.org)
  • Sedate with azaperone (Stresnil) and examine. (thepigsite.com)
  • There are three medicines available for sedating pigs, acetylpromazine (ACP), azaperone (stresnil) and primidone (mysoline). (thepigsite.com)
  • Azaperone (40mg/ml injection POM) Trade name Stresnil - This is a sedative and analgesic widely used in pigs and very effective. (thepigsite.com)
  • Effects of general anesthesia with ketamine in combination with the neuroleptic sedatives xylazine or azaperone on plasma metabolites and hormones in pigs. (fbn-dummerstorf.de)
  • We used habituated sheep Ovis aries ( N = 5, 46.9 ± 5.3 kg body mass, mean ± SEM) and goats Capra hircus ( N = 4, 27.7 ± 2.8 kg) as ungulate models for large wild animals, and measured their cardiorespiratory function under three conditions: (1) mild sedation (midazolam), as a proxy for the normal resting state, (2) immobilization (etorphine and azaperone), and (3) general anaesthesia (propofol) followed by etorphine antagonism (naltrexone). (springer.com)
  • 15 3.5-26 yr old) wild black rhinoceroses were immobilized with etorphine and azaperone and positioned in either sternal or lateral recumbency. (elsevier.com)
  • EXPLANATION Azaperone, a butyrophenone neuroleptic tranquillizer, was reviewed at the thirty-eighth and forty-third meetings of the Committee (Annex 1, references 97 and 113). (inchem.org)
  • Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. (wikipedia.org)
  • Azaperone is a neuroleptic sedative belonging to the butyrophenone class of pharmaceuticals. (livealthbiopharma.co.in)
  • In this study, equine liver/lung microsomes/S9 tissue fractions were used to study the phase I metabolism of eight drugs of relevance to equine drug surveillance (acepromazine, azaperone, celecoxib, fentanyl, fluphenazine, mepivacaine, methylphenidate and tripelennamine). (spectroscopynow.com)
  • The Committee noted that almost all of the primary metabolites previously found in vivo in rats and pigs were produced under the conditions of Ames' test and concluded that the mutagenic potential of azaperone and its metabolites in bacteria had been adequately evaluated in the previously conducted tests and particularly in the second, more throrough study described in the previous evaluation, in which the presence of metabolites was questioned. (inchem.org)
  • Azaperone may cause hypotension and while it has minimal effects on respiration in pigs, high doses in humans can cause respiratory depression. (wikipedia.org)
  • The most common use for azaperone is in relatively small doses to reduce aggression in farmed pigs, either to stop them fighting or to encourage sows to accept piglets. (wikipedia.org)
  • The European Medicines Agency has established a maximum residue limit for azaperone when administered to pigs. (wikipedia.org)
  • Azaperone can be used as tranquilizer to prevent stress during transportation of pigs. (pacificlab.vn)
  • Racemic ketamine in comparison to S-ketamine in combination with azaperone and butorphanol for castration of pigs. (uzh.ch)
  • After approval by our Institutional Research Commission and in accordance with the recommendations of the American Physiological Society for laboratory research involving animals, 19 farm pigs of both sexes (40 [1]kg) were premedicated with 10mg/kg intramuscular azaperone and anesthetized with 30mg/kg intravenous thiopental sodium. (revespcardiol.org)
  • After intramuscular premedication with 6 mg/kg azaperone, an intravenous line was obtained, and anesthesia was induced with 5 mg/kg thiopental in 14 female pigs weighing 29 ± 2 kg. (asahq.org)
  • A competitive enzyme immunoassay for screening and quantitative analysis of azaperone-azaperol in various matrices. (pacificlab.vn)
  • The major metabolite of azaperone is azaperol. (pacificlab.vn)
  • For control purposes the marker residue is therefore the sum of azaperone and azaperol, as both compounds show pharmacological activity. (pacificlab.vn)
  • The Azaperona-Azaperol ELISA is a competitive enzyme immunoassay based on antibodies against azaperone/azaperol. (pacificlab.vn)
  • The animals were immobilized in Namibia from a helicopter, by remote intramuscular injection of etorphine HCl, azaperone, and hyaluronidase. (capnography.com)
  • After an overnight fast, animals were premedicated intramuscularly with azaperone (80 mg), atropine (2 mg), and ketamine (600 mg). (asahq.org)
  • In this prospective intervention study 14 free-ranging white rhinoceroses were immobilised with a combination of etorphine, azaperone and hyaluronidase. (scielo.org.za)
  • Biotransformation was assessed by incubating 14 C-azaperone (0.01, 0.1, 0.5, or 2.0 mmol/plate) with rat liver fractions in buffer containing histidine, biotin, nutrient broth and a NADPH generating system at 37 C for 30 and 120 min. (inchem.org)
  • A preliminary investigation into the immobilising potential of a tiletamine/zolazepam mixture, metomidate, a metomidate and azaperone combination and medetomidine in ostriches (Struthio camelus). (thefreedictionary.com)
  • Using tranquilizers such as azaperone (2.2 mg/kg) or amperozide (1 mg/kg) can help reduce aggression but may not be economical. (msdvetmanual.com)
  • To support this statement, the biotransformation of azaperone was studied in vitro with microsomal fractions from the livers of Arochlor 1254-treated (500 mg/kg bw) male Wistar rats in order to identify the metabolites formed under the conditions of Ames' test. (inchem.org)
  • Azaperone is also used in combination with strong narcotics such as etorphine or carfentanil for tranquilizing large animals such as elephants. (wikipedia.org)
  • For both sheep and goats, systemic and pulmonary mean arterial pressures were significantly altered from initial midazolam levels when administered etorphine + azaperone, but those arterial pressures were restored upon transition to propofol anaesthesia and antagonism of the etorphine. (springer.com)
  • Under etorphine + azaperone, minute ventilation decreased in the sheep, though this decrease was corrected under propofol, while the minute ventilation in the goats remained unchanged throughout. (springer.com)
  • Under etorphine + azaperone, both sheep and goats displayed arterial blood hypoxia and hypercapnia (relative to midazolam levels), which failed to completely recover under propofol, indicating that more time might be needed for the blood gases to be adequately restored. (springer.com)
  • 2.2 Structural similarity to known carcinogens A brief discussion of the lack of similarity of azaperone and its metabolites with known carcinogens was included in the previous evaluation. (inchem.org)
  • 2. Evidence to support the claim that azaperone or its degradation products are not structurally similar to known carcinogens 3. (inchem.org)
  • Results of a study to assess the effects of azaperone on reproduction and fertility in male laboratory animals. (inchem.org)