Azathioprine
Azacitidine
Molecular Structure
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Sulfur Compounds
Spiro Compounds
Volatile Organic Compounds
6-Mercaptopurine
Structure-Activity Relationship
Small Molecule Libraries
Dose-Response Relationship, Drug
Plant Extracts
Benzamidines
Drug Evaluation, Preclinical
Furans
Methyltransferases
Magnetic Resonance Spectroscopy
Heterocyclic Compounds
Inhibitory Concentration 50
Marine Toxins
Organotin Compounds
Cyclosporine
Chromatography, High Pressure Liquid
DNA Methylation
Enzyme Inhibitors
Stereoisomerism
Drug Design
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
Organometallic Compounds
Organoselenium Compounds
Drug Screening Assays, Antitumor
Organophosphorus Compounds
Myelodysplastic Syndromes
Moxifloxacin: a comparison with other antimicrobial agents of in-vitro activity against Streptococcus pneumoniae. (1/758)
Two hundred representative isolates, including 26 strains of Streptococcus pneumoniae with intermediate resistance to penicillin, were selected from a collection obtained from blood cultures of patients with bacteraemic pneumococcal pneumonia. The MICs of moxifloxacin (BAY 12-8039), grepafloxacin, sparfloxacin, levofloxacin, ofloxacin, ciprofloxacin, erythromycin, tetracycline and penicillin G were determined by a standard agar dilution technique. Moxifloxacin had the highest in-vitro activity against S. pneumoniae (MIC90 = 0.25 mg/L; MIC range 0.06-0.25 mg/L). The MIC90 values were one dilution lower than those obtained with sparfloxacin and grepafloxacin, three dilutions lower than those obtained with levofloxacin, and four dilutions lower than those of ofloxacin and ciprofloxacin. (+info)The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus. (2/758)
In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to decreased fluoroquinolone susceptibility. Efflux pumps can be inhibited by the plant alkaloid reserpine, which, at 20 mg/L, reduced sparfloxacin, moxifloxacin and ciprofloxacin IC50s and MICs by up to four-fold in 11, 21 and 48 of the 102 unrelated clinical isolates tested, respectively. The effect was less pronounced with the hydrophobic drugs sparfloxacin and moxifloxacin than with the hydrophilic drug ciprofloxacin and was stable in all 25 clonally related isolates tested. (+info)Pharmacokinetics and inflammatory-fluid penetration of moxifloxacin following oral or intravenous administration. (3/758)
A single 400-mg oral or intravenous (i.v.) dose of moxifloxacin was given to each of eight healthy male volunteers, and 6 weeks later the dose was administered by the other route. The concentrations of the drug in plasma, cantharidin-induced inflammatory fluid, and urine were measured over the subsequent 24 h. The mean maximum concentrations observed in plasma were 4.98 microg/ml after oral dosing and 5.09 microg/ml after i.v. dosing. The mean maximum concentrations attained in the inflammatory fluid were 2.62 and 3.23 microg/ml, respectively. The mean elimination half-lives from plasma were 8.32 and 8.17 h, respectively. The overall penetration into the inflammatory fluid was 103.4 and 104.2%. Over 24 h 15% of the drug was recovered in the urine when administered by either route. (+info)Comparative in-vitro activities of moxifloxacin, trovafloxacin, quinupristin/dalfopristin and linezolid against staphylococci. (4/758)
The antistaphylococcal activities of four newly developed antibiotics, moxifloxacin (an 8-methoxyfluoroquinolone), trovafloxacin (a naphthyridone), quinupristin/dalfopristin (a semisynthetic streptogramin) and linezolid (an oxazolidinone), were examined and compared with those of ciprofloxacin, vancomycin and teicoplanin, using an agar dilution method. A total of 245 clinical isolates of staphylococci, including a large number of clonally different methicillin-resistant strains, were tested. The new agents tested exhibited wide-spectrum antistaphylococcal activity against both methicillin-susceptible and methicillin-resistant strains. In contrast to the quinolones, the in-vitro activities of quinupristin/dalfopristin, linezolid and the glycopeptides remained almost unchanged, irrespective of the resistance phenotype for methicillin. A number of isolates with elevated quinolone MICs were observed. (+info)Comparative susceptibility to penicillin and quinolones of 1385 Streptococcus pneumoniae isolates. Austrian Bacterial Surveillance Network. (5/758)
Antibiotic resistance among Streptococcus pneumoniae isolates has spread rapidly throughout the world since the first description of a strain with diminished susceptibility to penicillin in Australia in 1967. A total of 1385 strains of S. pneumoniae, collected in several centres throughout Austria, were assessed for their sensitivity to moxifloxacin, trovafloxacin, ciprofloxacin, ofloxacin, levofloxacin and lomefloxacin. The MICs were determined using the agar dilution method, according to NCCLS guidelines. Both moxlfloxacin and trovafloxacin showed good anti-pneumococcal activity in terms of MIC50 (both 0.125 mg/L) and MIC90 (both 0.25 mg/L). Less active, but with similar activity to each other, were ciprofloxacin and levofloxacin, each with an MIC50 of 1 mg/L and an MIC90 of 2 mg/L. Ofloxacin showed only moderate activity (MIC50, 1 mg/L; MIC90, 2 mg/L) and lomefloxacin was the least active compound (MIC50, 4 mg/L; MIC90, 8 mg/L). Both moxifloxacin and trovafloxacin at a concentration of < or = 0.5 mg/L inhibited all of the S. pneumoniae strains tested. (+info)In-vitro activity of moxifloxacin against fluoroquinolone-resistant strains of aerobic gram-negative bacilli and Enterococcus faecalis. (6/758)
MICs of the new fluoroquinolone, moxifloxacin, and those of ciprofloxacin, ofloxacin and sparfloxacin for 19 genetically characterized fluoroquinolone-resistant strains were determined by the agar dilution method. The MICs of moxifloxacin for Escherichia isolates with one mutation in gyrA (corresponding to Ser83-->Leu or Asp87-->Gly substitution) were 0.25-0.5 mg/L, while those of ciprofloxacin, ofloxacin and sparfloxacin were 0.06-0.25, 1 and 0.12-0.5 mg/L, respectively. These values were four- to 16-fold higher than those of the same antibiotics for the wild-type strain, E. coli KL16. Similar results were observed with clinical isolates of Salmonella spp. harbouring one mutation in gyrA leading to the substitution of Ser83 by Phe or Tyr. In the presence of two mutations in the E. coli gyrA gene, the MICs of moxifloxacin ciprofloxacin, ofloxacin and sparfloxacin were 2, 0.5, 4 and 1 mg/L, respectively; these were 32 times higher than the MICs of these agents for E. coli KL16. The MICs of the four quinolones for triple mutants with two mutations in gyrA and one in parC were even higher, i.e. 8, 8, 16 and 8-16 mg/L, respectively. The MICs of moxifloxacin for Campylobacter coli and Campylobacter jejuni strains with a gyrA mutation leading to Thr86-->Ile substitution ranged from 1 to 2 mg/L, while the MICs of ciprofloxacin, ofloxacin and sparfloxacin were 16-32 mg/L, 8-16 and 4-8 mg/L, respectively. For high-level ciprofloxacin-resistant (MICs of 32 mg/L) clinical isolates of Enterococcus faecalis with one substitution at position 83 in GyrA (E. coli coordinates), the MICs of moxifloxacin, ofloxacin and sparfloxacin were 8-16, > or = 128 and 32 mg/L respectively. In conclusion, moxifloxacin and other fluoroquinolones exhibit cross-resistance against aerobic gram-negative bacilli and enterococci. The in-vitro activity of moxifloxacin was greater than that of ofloxacin and slightly less than that of ciprofloxacin and sparfloxacin against Enterobacteriaceae, but greater than those of the three other compounds tested against Campylobacter spp and E. faecalis. (+info)The in-vitro activity of moxifloxacin against Legionella species and the effects of medium on susceptibility test results. (7/758)
The in-vitro activities of moxifloxacin, ciprofloxacin, erythromycin and rifampicin against 49 Legionella spp. isolates were determined by an agar dilution method with buffered charcoal yeast extract agar containing alpha-ketoglutarate. Because the inhibitory effects of charcoal in the test media were pronounced (92% for quinolones, 90.5% for rifampicin and 92.5% for erythromycin), the MICs were corrected for the charcoal-bound fraction of the antibiotics. The corrected geometric mean MICs were 0.018 mg/L for moxifloxacin, 0.02 mg/L for ciprofloxacin, 0.27 mg/L for erythromycin and 0.005 mg/L for rifampicin. (+info)The effect of moxifloxacin on its target topoisomerases from Escherichia coli and Staphylococcus aureus. (8/758)
The effect of moxifloxacin on its target enzymes was evaluated by three different approaches: (i) the MICs of moxifloxacin and nine other fluoroquinolones were determined for mutants of Escherichia coli (n = 13) and Staphylococcus aureus (n = 5) carrying different combinations of resistance mutations; (ii) the activity of moxifloxacin on isolated targets was determined as IC50 values for wild-type and mutant type II topoisomerases from E. coli; and (iii) the mutation frequencies were determined for two single-step mutants (MI with a Ser83-->Leu mutation in gyrA and WT-4 with a Ser80-->Ile mutation in parC) and their parent strain (WT). Of the quinolones tested, moxifloxacin was the only one showing an equivalent high activity against both targets. This is reflected by a comparable high susceptibility of the test strains of E. coli and S. aureus and by the IC50 values of moxifloxacin which were 50-90% lower than those of ciprofloxacin, norfloxacin and sparfloxacin for the wild-type and single mutant enzymes of gyrase and topoisomerase IV. However, double mutant GyrA was significantly more sensitive to moxifloxacin than to the other fluoroquinolones tested, while wild-type topoisomerase IV was two-fold more refractory. Mutation rates of WT, MI and WT-4 for ciprofloxacin and moxifloxacin were 5 x 10(-8) vs 4 x 10(-10); <6 x 10(-11) vs <6 x 10(-11); and 2 x 10(-6) vs 5 x 10(-7), respectively. These data indicate an equivalent high inhibitory activity of moxifloxacin on DNA gyrase and topoisomerase IV of E. coli. (+info) Myelodysplastic syndromes (MDS) are a group of rare and diverse blood disorders that affect the bone marrow, where blood cells are produced. MDS is characterized by the production of immature or abnormal blood cells, which can lead to anemia, infection, bleeding, and an increased risk of developing leukemia.
There are several subtypes of MDS, each with distinct clinical features and prognosis. The most common subtype is refractory anemia with excess blasts (RAEB), followed by chronic myelomonocytic leukemia (CMMoL) and acute myeloid leukemia (AML).
The exact cause of MDS is not fully understood, but it is believed to result from a combination of genetic mutations and environmental factors. Risk factors for developing MDS include exposure to certain chemicals or radiation, age over 60, and a history of previous cancer treatment.
Symptoms of MDS can vary depending on the specific subtype and severity of the disorder, but may include fatigue, weakness, shortness of breath, infection, bleeding, and easy bruising. Diagnosis is typically made through a combination of physical examination, medical history, blood tests, and bone marrow biopsy.
Treatment for MDS depends on the specific subtype and severity of the disorder, as well as the patient's overall health and preferences. Options may include supportive care, such as blood transfusions and antibiotics, or more intensive therapies like chemotherapy, bone marrow transplantation, or gene therapy.
Overall, myelodysplastic syndromes are a complex and heterogeneous group of disorders that can have a significant impact on quality of life and survival. Ongoing research is focused on improving diagnostic accuracy, developing more effective treatments, and exploring novel therapeutic approaches to improve outcomes for patients with MDS.
List of phenyltropanes
Bi- and tri-cyclic aza compounds and their uses. ɑIC50 for displacement of [3H]cocaine. IC50 for cocaine = 67.8 ± 8.7 (nM) ... U.S. Patent 6,150,376 WO 0007994, Kozikowski, Alan P. & Smith, Miles P., "Novel bi- and tri-cyclic aza compounds and their uses ... N.B. In the case of both nocaine and pethidine, N-demethyl compounds are more toxic and have a decreased seizure threshold. ... Therefore it is to be expected that within different contexts a compound or chemical of the same name very possibly could be in ...
Progesterone 3-oxime
Aza-steroids. Part VII. 3-aza-A-homopregn-4a-ene and related compounds". Journal of the Chemical Society (Resumed): 3388. doi: ...
Azelaic acid
... (AzA) is an organic compound with the formula HOOC(CH2)7COOH. This saturated dicarboxylic acid exists as a white ... In a comparative review of effects of topical AzA, Salicylic acid, Nicotinamide, Sulfur, Zinc, and alpha-hydroxy acid, AzA had ... AzA inhibits tyrosinase. Azelaic acid is industrially produced by the ozonolysis of oleic acid. The side product is nonanoic ... The effectiveness of long term use is unclear, but it's been recommended that AzA be used for at least 6 months continuously ...
Polysilazane
Silicon-nitrogen compounds with alternating silicon- ("sila") and nitrogen atoms ("aza") are designated as silazanes. Simple ... the compound would actually be named poly[aza(dimethylsilylene)], and according to the preliminary rules for inorganic ... After compounding, casting and curing, the thermoset material can be pyrolyzed in one step to give a ceramic component in high ... macromolecules catena-poly[(dimethylsilicon)-m-aza]. The labels normally used to describe the structure of silicones (M, D, T, ...
Imine
tosylimines react with α,β-unsaturated carbonyl compound to give allylic amines in the Aza-Baylis-Hillman reaction. Somewhat ... When R = H, the compound is a primary imine, when R is hydrocarbyl, the compound is a secondary imine. If this group is not a ... For obviously piperidine also belongs in the class of compounds that are sought by me, for which the name "imines" is indicated ... In the older literature, imine refers to the aza-analogue of an epoxide. Thus, ethylenimine is the three-membered ring species ...
Diels-Alder reaction
... to form various N-heterocyclic compounds through the aza-Diels-Alder reaction. Nitroso compounds (R-N=O) can react with dienes ... Bradsher cycloaddition Wagner-Jauregg reaction Imine Diels-Alder reaction Aza-Diels-Alder reaction Diels-Alderases, enzymes ... Behr, Arno (2000). "Organometallic Compounds and Homogeneous Catalysis". Ullmann's Encyclopedia of Industrial Chemistry. doi: ...
Fenestrane
In one study, a [4.5.5.5]fenestrane was synthesized with one carbon atom replaced by nitrogen because aza- compounds and their ... A fenestrane in organic chemistry is a type of chemical compound with a central quaternary carbon atom which serves as a common ... They can be regarded as spiro compounds twice over. Because of their inherent strain and instability, fenestranes are of ... salts are more likely to form crystalline compounds suitable for X-ray analysis than low-molecular-weight alkanes. In step 1 ...
Aza-crown ether
This compound serves as a building block for macrocyclizations. Many kinds of aza crown ethers exist. Variable length linkers ... In organic chemistry, an aza-crown ether is an aza analogue of a crown ether (cyclic polyether). That is, it has a nitrogen ... 2.2.2-Cryptand is an aza-crown of the mixed ether-amine variety. The synthesis of aza crown ethers are subject to the ... Well-studied aza crowns include triazacyclononane (n = 3), cyclen (n = 4), and hexaaza-18-crown-6 (n = 6). Selected aza-crowns ...
Azadirachtin
... hence the prefix aza does not imply an aza compound, but refers to the scientific species name). Many more compounds, related ... Azadirachtin, a chemical compound belonging to the limonoid group, is a secondary metabolite present in neem seeds. It is a ... If the insect ingests the compound, the substance further inhibits digestive enzymes and could leave an aversive taste memory ... Hence, the first total synthesis was published over 22 years after the compound's discovery: this first synthesis was completed ...
Azakhel Payan
The word Azakhel Payan is a linguistic compound consisting of three words. Aza is probably the name of its founder. The word ... Instead, the name Aza Khel may derive from Za Khel, a town in Kondoz, Afghanistan. Azakhel Payan is bordered by the Cherat ... According to one theory, the name Aza Khel was given to the village by its founder. The founder may have been Raza Khan. Raza ... Khan, also spelled Aza Khan, is considered a legendary Afghan warrior.[by whom?] Raza Khan had seven brothers, one of whom was ...
Organic azide
... react with carbonyl compounds to give imines 24 (the aza-Wittig reaction), or undergo other transformations. Thermal ... Chemistry of Heterocyclic Compounds: A Series Of Monographs. New York, USA: John Wiley & Sons, Inc. doi:10.1002/0471221902. ... The azo-transfer compounds, trifluoromethanesulfonyl azide and imidazole-1-sulfonyl azide react with amines to give the ... On a new class of compounds in which nitrogen is substituted for hydrogen". Proceedings of the Royal Society of London. 13: 375 ...
Hydrogen-bond catalysis
In addition, aza-Friedel-Crafts reactions of furans, amidoalkylations of diazocarbonyl compounds, asymmetric ... For example, in a typical acyl substitution reaction, the starting carbonyl compound is coordinated to the catalyst through one ... Furthermore, analogous reactions involving oxyanion intermediates such as enolate addition to nitroso compounds or opening of ... attractive strategy since the anionic tetrahedral intermediates are better hydrogen-bond acceptors than the starting compound. ...
Boraacenes
Bis-(dimesitylboryl)-azaborine, a boron nitrogen aromatic compound similar in structure to 9-aza-10-boraanthracene, was shown ... 10-Dihydro-9-aza-10-boraanthracene as a Precursor for Various Boron- and Nitrogen-Containing π-Conjugated Compounds". Organic ... The compound overall is highly reactive to air and needs to be stored under inert atmosphere. For the boraacenes possessing an ... 9-aza-10-boraanthracene has peak absorption around 427 nm and broad emission around 513 nm, with HOMO-LUMO gap of 3.075 eV, ...
Aza-
The prefix aza- is used in organic chemistry to form names of organic compounds where a carbon atom is replaced by a nitrogen ... While the above figure gives examples of 4-aza steroids, 6-aza steroids have also been developed by GSK, although none of these ... compounds, as yet, are available for sale commercially. IUPAC nomenclature of organic chemistry "Chemical Identifier Search , 4 ...
Diethyl azodicarboxylate
DEAD is an aza-dienophile and an efficient dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides and ... Safety hazards have resulted in rapid decline of DEAD usage and replacement with DIAD and other similar compounds. Diethyl azo ... It has also been used to generate aza-Baylis-Hillman adducts with acrylates. DEAD can be used for synthesis of heterocyclic ... Thus, in general DEAD is an aza-dienophile and dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides ...
Aza-Cope rearrangement
... although other silver and copper compounds have been used. This added step allows for more precise control of iminium ion ... Thus the 3-aza Cope's large activation barriers are kinetically based. Research on both the 1 and 3-aza-Cope rearrangements has ... The 3-aza-Cope rearrangement (and thus also the 1-aza-Cope rearrangement, which goes through the same transition state) is ... The 3-aza-Cope reaction was discovered soon after the 2-aza-Cope rearrangement was identified, due to its analogous ...
Tetrahedral carbonyl addition compound
The more recent x-ray crystal structure of 1-aza-3,5,7-trimethyladamantan-2-one is a good model for cationic tetrahedral ... compounds with donor groups that are poorly conjugated with the potential carbonyl group (e.g. cyclol) compounds with sulfur ... 3.0.co;2-u. Bell, R. P. (1966). "The reversible hydration of carbonyl compounds". Adv. Phys. Org. Chem. Advances in Physical ... The chart below shows the extent of hydration of some carbonyl compounds. Hexafluoroacetone is probably the most hydrated ...
Inverse electron-demand Diels-Alder reaction
Aromatic compounds can also react in DAINV reactions, such as triazines and tetrazines. Other common classes of dienes are oxo ... and aza- butadienes. The key quality of a good DAINV diene is a significantly lowered HOMO and LUMO, as compared to standard DA ... DAINV reactions have been utilized for the synthesis of several natural products, including (-)-CC-1065, a parent compound in ... DAINV reactions often involve heteroatoms, and can be used to form heterocyclic compounds. This makes the DAINV reaction ...
Cyclam
... (1,4,8,11-tetraazacyclotetradecane) is an organic compound with the formula (NHCH2CH2NHCH2CH2CH2)2. Classified as an aza ... The compound was first prepared by the reaction of 1,3-dibromopropane and ethylenediamine. The compound features four secondary ...
5-Aza-7-deazapurine
... or imidazo[1,2-a][1,3,5]triazine is a heterocyclic aromatic organic compound that consists of a s-triazine ... However, in 5-aza-7-deazapurine, N-9 of five-membered ring does not bond with hydrogen. So 5-aza-7-deazapurine derivatives must ... 5-Aza-7-deazapurine nucleosides may have an oxo, thioxo, or a imine group. Notable derivatives of this molecule include 5-aza-7 ... "5-Aza-7-deazaguanine DNA: Recognition and Strand Orientation of Oligonucleotides Incorporating Anomeric Imidazo[1,2-a]-1,3,5- ...
5-Aza-7-deazaguanine
Organic compound stubs). ... one is a 5-Aza-7-deazapurine base that is an isomer of guanine ... 5-Aza-7-deazaguanine or 2-aminoimidazo[1,2-a][1,3,5]triazin-4(1H)- ...
Stannatrane
Jurkschat, K.; Tzschach, A. (1984). "1-Aza-5-stanna-5,5-dimethylbicyclo[3.3.01,5] octan und 1-aza-5-stanna-5-methyltricyclo[3.3 ... Heterocyclic compounds with 3 rings, Tin(IV) compounds, Atranes). ... A stannatrane (IUPAC: 1-aza-5-stannabicyclo[3.3.3]undecane) is a tin-based atrane belonging to the larger class of ... Evidence for a transannular donor−acceptor interaction in a tetraorganotin compound". Journal of Organometallic Chemistry. 315 ...
12-Crown-4
98%, 2018 Crown ether Cyclen, a similar molecule with N atoms (aza groups) instead of O atoms (ethers) (Chemical articles with ... multiple compound IDs, Multiple chemicals in an infobox that need indexing, Articles without KEGG source, ECHA InfoCard ID from ...
Fresno Chaffee Zoo
... and on-site feed and medical compounds. The zoo became an institutional member of the AZA in 1957. In 1965 Paul S. Chaffee was ... aza.org. AZA. Retrieved 27 June 2011. "Zoos and Aquariums of the World". waza.org. WAZA. Retrieved 27 June 2011. "Species". ... The zoo is accredited by the Association of Zoos and Aquariums (AZA) and is a member of the World Association of Zoos and ... AZA) officially recognized the park opening in 1929 as the Roeding Park Zoo. Only few animals were seen, but that number would ...
Baylis
... to give an allylic alcohol Aza-Baylis-Hillman reaction, the reaction of an α,β-unsaturated carbonyl compound with an imine in ...
Azaborane
Carborane Lenka Schneider, Ulli Englert, Peter Paetzold (1994). "Die Kristallstruktur von Aza‐closo‐decaboran NB9H10". Z. Anorg ... CS1 maint: uses authors parameter, Boron-nitrogen compounds, Cluster chemistry, Boranes). ... Azaboranes can also refer to simpler compounds including iminoboranes (formula = RN=NR') and borazines. ...
Dioscorine
Convulsions in humans can be readily antagonized with this compound. Boorsma,. Meded. vits Lands Plant 1894, 13. Levya,; ... Several developed antidotes are aza-bridged bicyclic amine derivatives. An anesthetic, pentobarbital sodium, was often ... Pubchem.ncbi.nlm.nih.gov,. Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands https://pubchem ... Pubchem.ncbi.nlm.nih.gov,. DIOSCORINE , C13H19NO2 - PubChem https://pubchem.ncbi.nlm.nih.gov/compound/442635#section=Chemical- ...
Strictosidine synthase
... the universal precursor for monoterpenoid indole alkaloid compounds. It also catalyses the formation of 12-aza-strictosidine, ... One such investigation found (21S)-12-aza-nacycline, a 12-aza-strictosidine derivative, to exhibit potent cytotoxicity to the ... Unlike the mechanisms behind the formation of several Pictet-Spengler compounds, a spiroindolenine intermediate containing a ... an important intermediate for cytotoxic alkaloids, from coupling secologanin with 7-aza-tryptamine. The enzyme is encoded by a ...
Diisopropyl azodicarboxylate
It is used as a reagent in the production of many organic compounds. It is often used in the Mitsunobu reaction, where it ... It has also been used to generate aza-Baylis-Hillman adducts with acrylates. It can also serve as a selective deprotectant of N ... One notable use of this compound is in the synthesis of Bifenazate (Floramite®).[citation needed] "luka DIAD on Sigma-Aldrich ... Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Articles without EBI source ...
Deoxycytidine
It can also be used as a precursor for 5-aza-2′-deoxycytidine, a treatment for MDS patients. This compound slows the cell cycle ... Hydroxymethyl compounds, All stub articles, Biochemistry stubs). ...
6-Amino-5-nitropyridin-2-one
Nitro compounds, Amines, All stub articles, Organic compound stubs). ... It is used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine. Hoshika, Shuichi; et al. (22 February ...
GABAA receptor positive allosteric modulator
Possible drug candidates were then synthesized from that compound and screened for activity. One of these compounds was active ... 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and ( ... He thought the compound had a heptoxdiazine structure (Figure 7) but it was later determined to be a quinazoline-3-oxide. ... The earliest compounds were ions, such as bromide. In 1903, the first psychoactive derivative of barbituric acid was ...
Intramolecular reaction
... and aza-bicyclo[2,1,1]hexanes". J. Chem. Soc. D. 19 (19): 1167. doi:10.1039/C29710001167. Corey, E. J.; Kang, M. C.; Desai, M. ... many intramolecular reactions that would not occur as an intermolecular reaction between two compounds take place. Examples of ... reactions have been used to synthesize organic compounds with interesting ring systems and topologies. For example, [2+2] ...
Polyene
Poly(aza)acetylenes are readily prepared from pyridine precursors without the necessity of a controlled atmosphere, simply by ... In organic chemistry, polyenes are poly-unsaturated, organic compounds that contain at least three alternating double (C=C) and ... resulting in compounds which are coloured (because they contain a chromophore). Thus many natural dyes contain linear polyenes ...
Ionic liquid
Examples include compounds based on the 1-ethyl-3-methylimidazolium (EMIM) cation and include: EMIM:Cl, EMIMAc (acetate anion ... imide Aza-Baylis-Hillman reaction for the use of a chiral ionic liquid in asymmetric synthesis. Ionic liquids in carbon capture ... Saturated aliphatic compounds are generally only sparingly soluble in ionic liquids, whereas alkenes show somewhat greater ... They offer the specificity required to separate similar compounds from each other, such as separating polymers in plastic waste ...
Epigenetic therapy
One approach is to inhibit the methylation of the Sod2 and MMP-9. The DNMT inhibitors 5-azacytidine and 5-aza-20-deoxycytidine ... compounds which increase learning may also increase re-consolidation, ultimately strengthening the memory. A number of cardiac ... The DNMT inhibitors 5-azacytidine and 5-aza-20-deoxycytidine mentioned above have both been approved by the FDA for the ... and studies have examined the effects of those compounds on diabetic retinopathy, where they seem to inhibit these methylation ...
Bioorthogonal chemistry
The reaction was modified to include an ester group ortho to the phosphorus atom on one of the aryl rings to direct the aza- ... and it has also been used in the generation of SPECT imaging compounds. More recently, the use of an oxanorbornadiene was ... Through a four-membered transition state, N2 is lost to form an aza-ylide. The unstable ylide is hydrolyzed to form phosphine ... However, this reaction is not immediately bioorthogonal because hydrolysis breaks the covalent bond in the aza-ylide. ...
Pharmacoepigenetics
CYP1A1 is a protein that is well known for its role in chemical compounds and drug metabolism. A study in prostate cancer ... may try to decrease CpG methylation by using a drug that works as DNA methytransferase inhibitor such as decitabine or 5-aza-2 ... alkylguanine in DNA to itself to fight against mutagenesis and the buildup of toxic compounds that result from alkylating ... and understand drug response to treatments such as target compounds, traditional chemotherapy agents, and epigenetic drugs. ...
Povarov reaction
Treatment of these compounds with TBAF invokes a ring-expansion that provides the corresponding benzazepines. One variation of ... The reaction is also classified as a subset of aza Diels-Alder reactions The reaction depicted in Scheme 2 illustrates the ... The imine in this organic reaction is a condensation reaction product from an aniline type compound and a benzaldehyde type ... a dirhodium catalyst effects diazo decomposition from silyl enol ether diazo compound to yield a donor/acceptor cyclopropene. ...
Kirsanov reaction
The Kirsanov reaction is a method for the synthesis of certain organophosphorus compounds. In this reaction a tertiary ... Eguchi, Shoji; Matsushita, Yuji; Yamashita, Keizo (April 1992). "The Aza-Wittic Reaction in Heterocyclic Synthesis. A Review". ...
Aza-Baylis-Hillman reaction
... β-unsaturated carbonyl compound, with an imine in the presence of a nucleophile. The reaction product is an allylic amine. The ... The aza-Baylis-Hillman reaction or aza-BH reaction in organic chemistry is a variation of the Baylis-Hillman reaction and ... Aza-BH reactions are known in asymmetric synthesis by making use of chiral ligands. In one study, for the first time, ... Because this step is also reversible the presence of acid causes a racemisation process simply by mixing chiral aza-BH adduct, ...
Epigenetics of neurodegenerative diseases
5-aza-2' deoxycitidine (AZA, or decitabine), a DNMT inhibitor, has shown some evidence for regulating neuroglobin expression, ... Histone deacetylase (HDAC) inhibitors are the main compounds that have been tested to increase SMN2 mRNA expression. Inhibiting ... AZA Khan and colleagues have demonstrated a potential role for neuroglobinin attenuating amyloid-related neurotoxicity. ...
Aptazapine
It is a potent α2-adrenergic receptor antagonist with ~10x the strength of the related compound mianserin and has also been ... for alpha 2-adrenoceptor blockade in the central nervous system and the effects of the enantiomers of mianserin and its aza- ...
List of California Institute of Technology people
... one of the pioneers of NMR as a tool to study organic compounds, winner of the National Medal of Science (1990) and the ... statistician Aza Raskin, graduate studies, design expert, interface guru, and entrepreneur Huck Seed, undergraduate studies, ... known for contributions to chemical vapor deposition of compound semiconductors Mark Kushner, PhD 1979; George I Haddad ...
Stieglitz rearrangement
Heesing, A.; Herdering, W. (January 1981). "Sauerstoff-insertion bei der umlagerung von 2-aza-bicyclo[2.2.1]hept-2-enderivaten ... X/1, 4th Edition: Nitro, Nitroso and Hydroxylamine Compounds (4 ed.). Georg Thieme Verlag. p. 1266. ISBN 9783131805546. Ayres, ... Application to the synthesis of heterocyclic compounds". Journal of Heterocyclic Chemistry. 33 (5): 1489-1496. doi:10.1002/jhet ...
Aquarium
List of aquaria Association of Zoos and Aquariums (AZA) List of aquarium diseases List of aquarium fish by scientific name List ... When plants metabolize nitrogen compounds, they remove nitrogen from the water by using it to build biomass that decays more ... This problem is most often addressed through two filtration solutions: Activated carbon filters absorb nitrogen compounds and ...
FCE 28260
EP 0782582, di Salle E, Nesi M, Panzeri A, "Epimers of (22RS)-N-(1,1,1-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5α-androst-1- ... Trifluoromethyl compounds, All stub articles, Genito-urinary system drug stubs). ...
Crown ether
Aza-crown ether Thia-crown ether Cryptand Metallacrown van der Ham, Alex; Hansen, Thomas; Lodder, Gerrit; Codée, Jeroen D. C.; ... Marczenko, K. M.; Mercier, H. P. A.; Schrobilgen, G. J. (2018). "A Stable Crown-Ether Complex with a Noble-gas Compound". Angew ... In organic chemistry, crown ethers are cyclic chemical compounds that consist of a ring containing several ether groups (R−O−R ... By incorporating luminescent substituents into their backbone, these compounds have proved to be sensitive ion probes, as ...
Candocuronium iodide
17a-Methyl-3β-(N-pyrrolidinyl)17a-aza-D-homo-5α-androstane bis(methiodide)(dihydrochandonium iodide) and certain other ... and bis-quaternary azasteroid series of compounds to which candocuronium belongs are based on the same principle that led to ... Chandonium iodide (17a-methyl-3β-pyrrolidino-17a-aza-D-homoandrost-5-ene dimethiodide) and other quaternary ammonium steroid ... "Neuromuscular and other blocking actions of a new series of mono and bisquaternary aza steroids". J Pharm Pharmacol. 26 (11): ...
Canadian Reference Materials
"Arsenobetaine and other arsenic compounds in the National Research Council of Canada Certified Reference Materials DORM 1 and ... domoic acid standard Diarrhetic shellfish poisoning and other lipophilic toxins AZA, azaspiracid standards DSP-Mus, mussel ...
L-selectride
N-selectride and K-selectride are related compounds, but instead of lithium as cation they have sodium and potassium cations ... S. D. Knight, L. E. Overman and G. Pairaudeau (1993). "Synthesis applications of cationic aza-Cope rearrangements. 26. ... Lithium compounds, Organoboranes, Organolithium compounds, Reducing agents). ...
Via Crucis to the Cruz del Campo
The difficulties are compounded by the tendency of most sources to give only one version of events, even when the facts are in ... José María García de Tuñón Aza, Segura, el cardenal que expulsó la II República, El Catoblepas, Number 88, 2009-06, p. 13. ...
Atrane
It is also proposed that when Y = nitrogen, the prefix "aza" be inserted before element + "atrane" (azasilatrane, for example) ... Commons category link from Wikidata, Heterocyclic compounds, Atranes). ...
Finasteride
... , also known as 17β-(N-tert-butylcarbamoyl)-4-aza-5α-androst-1-en-3-one, is a synthetic androstane steroid and 4- ... As an unconjugated steroid, finasteride is a highly lipophilic compound. In 1942, James Hamilton observed that prepubertal ... brands, Carboxamides, Hair loss medications, Hair removal, Delta-lactams, Teratogens, Tert-butyl compounds). ... 4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase ...
Tulsa Zoo
AZA. Retrieved 3 May 2011. "List of Accredited Museums" (PDF). aam-us.org. American Alliance of Museums. Archived from the ... 1992 - Construction began on the new main entry, gift shop, elephant compound, commissary, exhibits building, animal reserve, ... The Tulsa Zoo also held the AZA National Conference in September. 1999 - Siamang/langur habitat and overlook completed. Also ... ". "Currently Accredited Zoos and Aquariums". aza.org. ...
Quinoline
... he called the compound Chinoilin or Chinolein. Runge's and Gephardt's compounds seemed to be distinct isomers because they ... an aza derivative of quinoline Quinine Similar simple aromatic rings Isoquinoline, an analog with the nitrogen atom in position ... Quinolinium compounds (e.g. salts) can also be used as corrosion inhibitors and intensifiers. Quinoline alkaloids 4- ... Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. It is a colorless hygroscopic liquid ...
Enantioselective synthesis
A chiral auxiliary is an organic compound which couples to the starting material to form a new compound which can then undergo ... Aza-Baylis-Hillman reaction, for the use of a chiral ionic liquid in enantioselective synthesis Kelliphite, a chiral ligand ... One of the most accurate ways of determining the chirality of compound is to determine its absolute configuration by X-ray ... The first of these was X-ray crystallography, which was used to determine the absolute configuration of an organic compound by ...
Preclinical safety evaluation of moxifloxacin, a novel fluoroquinolone
STRUCTURAL STUDIES OF ORGANOBORON COMPOUNDS .19. 1,7-DIMETHYL-3,5-DIPHENYL-2,4,6-TRIOXA-7-AZA-1-AZONIA-3-BORA-5-BORATABIC YCLO...
STRUCTURAL STUDIES OF ORGANOBORON COMPOUNDS .19. 1,7-DIMETHYL-3,5-DIPHENYL-2,4,6-TRIOXA-7-AZA-1-AZONIA-3-BORA-5-BORATABIC YCLO[ ... STRUCTURAL STUDIES OF ORGANOBORON COMPOUNDS .19. 1,7-DIMETHYL-3,5-DIPHENYL-2,4,6-TRIOXA-7-AZA-1-AZONIA-3-BORA-5-BORATABIC YCLO[ ... STRUCTURAL STUDIES OF ORGANOBORON COMPOUNDS .19. 1,7-DIMETHYL-3,5-DIPHENYL-2,4,6-TRIOXA-7-AZA-1-AZONIA-3-BORA-5-BORATABIC YCLO[ ...
New 64Cu PET imaging agents for personalised medicine and drug development using the hexa-aza cage, SarAr - PubMed
PubChem Compound (MeSH Keyword) * PubChem Substance LinkOut - more resources *. Full Text Sources. * Royal Society of Chemistry ... New 64Cu PET imaging agents for personalised medicine and drug development using the hexa-aza cage, SarAr Nadine Di Bartolo 1 ... New 64Cu PET imaging agents for personalised medicine and drug development using the hexa-aza cage, SarAr Nadine Di Bartolo et ... Synthesis of hexa aza cages, SarAr-NCS and AmBaSar and a study of their metal complexation, conjugation to nanomaterials and ...
Review of third-and fourth-generation fluoroquinolones in ophthalmology: in-vitro and in-vivo efficacy - PubMed
Publication Detail
MeSH Terms: Aza Compounds/chemistry*; Cell Survival; Formaldehyde/analysis*; Formaldehyde/chemistry*; HEK293 Cells; Humans; ... The results provide a starting point for the broader use of 2-aza-Cope reactivity for probing and manipulating FA biology. ... Title: Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells. ... iterative development of a general reaction-based trigger utilizing 2-aza-Cope reactivity for selective and sensitive detection ...
Biomarkers Search
Palladium-Catalyzed Inverse and Normal Dehydrogenative Aza-Morita-Baylis-Hillman Reactions with γ,δ-Unsaturated Compounds. ... 3. P-chirogenic organocatalysts: application to the aza-Morita-Baylis-Hillman (aza-MBH) reaction of ketimines.. Takizawa S; ... 2. [Development of acid-base organocatalysts for enantioselective aza-Morita-Baylis-Hillman (aza-MBH) reactions via dual ... 5. Asymmetric catalytic aza-Morita-Baylis-Hillman reaction for the synthesis of 3-substituted-3-aminooxindoles with chiral ...
MeSH Browser
Aza Compounds Preferred Term Term UI T004018. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1972). ... Aza Compounds Preferred Concept UI. M0002056. Registry Number. 0. Scope Note. Organic chemicals where carbon atoms have been ... AZA CPDS. Registry Number. 0. Previous Indexing. specific parent compound (1972-1973). Public MeSH Note. 74. History Note. 74( ... Aza Compounds. Tree Number(s). D02.145. Unique ID. D001372. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D001372 ...
NIH Common Fund
Fu created novel aza-β-lactam (ABL) compounds, relatives of penicillin and other β-lactam antibiotics, and provided them to the ... This compound interacts with a protein called S1P1, a receptor on the surface of cells that binds to specific molecules and ... A compound originally identified with the support of the Molecular Libraries program has led to a drug candidate now entering a ... The experimental compound, CB-5083, inhibits a protein called p97 that is critical to many cellular functions, including cell ...
DeCS
MeSH Browser
Aza Compounds Preferred Term Term UI T004018. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1972). ... Aza Compounds Preferred Concept UI. M0002056. Registry Number. 0. Scope Note. Organic chemicals where carbon atoms have been ... AZA CPDS. Registry Number. 0. Previous Indexing. specific parent compound (1972-1973). Public MeSH Note. 74. History Note. 74( ... Aza Compounds. Tree Number(s). D02.145. Unique ID. D001372. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D001372 ...
13R,14S,18R,19S)-9,19-dihydroxy-16-oxido-16-oxo-5,7,15,17-tetraoxa-12-aza-16lambda5-phosphapentacyclo[11.7.0.02,10.04,8.014,18...
will vanacof make you pop hot on a drug test - lookformedical.com
RFA-CA-03-016: DIET, DNA METHYLATION AND OTHER EPIGENETIC EVENTS, AND CANCER PREVENTION
... aza-dC). This compound has been used as a therapeutic agent for certain cancers, although treatment-associated side effects ... Sensitizing tumor cells to the bioactive food component can also be accomplished by using demethylating agents, such as 5-aza-2 ... Treatment of several cell lines with MLL (mixed-lineage leukemia or myeloid/lymphoid leukemia) translocations with 5-aza-dC ... is possible with inducers of general glutathione S-transferase activity and one such inducer is the isothiocyanate compound ...
Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect
Keywords: Aza Compounds Chemistry, Circular Dichroism, Dna Chemistry, Lanthanum Chemistry, Ligands, Macrocyclic Compounds ... Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound ... Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (708 views). J Chem Res (ISSN: 0162-0134, ... A preliminary investigation of the biological potential of this compound was conducted using a biomedically relevant target ...
RU2747292C1 - Method for activating germination of sugar beet seeds - Google Patents
METVSRFIOHSNJX-UHFFFAOYSA-N 5-(chloromethyl)-4,6,11-trioxa-1-aza-5-silabicyclo[3.3.3]undecane Chemical compound O1CCN2CCO[Si]1( ... SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 ... XUIMIQQOPSSXEZ-UHFFFAOYSA-N silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims abstract description 7 ... RMAQACBXLXPBSY-UHFFFAOYSA-N Silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1 ...
PAR-02-175: DIET, DNA METHYLATION AND OTHER EPIGENETIC EVENTS, AND CANCER PREVENTION:
COMPETING SUPPLEMENTS
5-aza-dC). This compound has been used as a therapeutic agent for certain cancers, although treatment-associated side effects ... Sensitizing tumor cells to the bioactive food component can also be accomplished by using demethylating agents, such as 5-aza-2 ... Treatment of several cell lines with MLL (mixed-lineage leukemia or myeloid/lymphoid leukemia) translocations with 5-aza-dC ... is possible with inducers of general glutathione S-transferase activity and one such inducer is the isothiocyanate compound ...
Pesquisa | Portal Regional da BVS
In terms of potency to cause bradycardia the compounds were ranked AZB>bupivacaine>AZA>lidocaine>nifedipine. Comparison with ... This study was undertaken to examine the effect on the rat embryonic heart of two experimental drugs (AZA and AZB) which are ... The results showed that AZA and AZB caused a concentration-dependent bradycardia of the embryonic heart and at high ... results from previous studies with more specific ion channel blockers suggests that the primary effect of AZA and AZB was ...
NDF-RT Code NDF-RT Name
N0000183499 Axin Signaling Complex N0000180228 Axonemal Dyneins N0000011324 Aza Compounds N0000178749 Azabicyclo Compounds ... Compounds N0000007682 Organomercury Compounds N0000007683 Organometallic Compounds N0000007684 Organophosphorus Compounds ... Compounds N0000007804 Organoselenium Compounds N0000008206 Organosilicon Compounds N0000008079 Organotechnetium Compounds ... 1-Ring N0000008260 Heterocyclic Compounds, 2-Ring N0000008096 Heterocyclic Compounds, 3-Ring N0000008258 Heterocyclic Compounds ...
NIOSHTIC-2 Search Results - Full View
... polynuclear aza heterocyclic hydrocarbons, aromatic amines, metals, common toxic gases, and other organic compounds. Sampling ... with the light molecular weight compounds in higher concentrations than the four through seven ring compounds. Some specific ... Aromatic amines, phenolic compounds and simple aromatic solvents were occasionally present at very low levels. High levels of ... the presence of these compounds may represent a skin exposure hazard. The fixed bed process produced significantly higher ...
Crown Compounds | Profiles RNS
Aza-Thia Crown Compounds*Aza-Thia Crown Compounds. *Aza Thia Crown Compounds ... "Crown Compounds" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Crown Compounds" by people in this website by year, and ... Macrocyclic compounds analogous to CROWN ETHERS but which lack any OXYGEN atoms. ...
Other Pharmacology mentored projects (9)
One such treatment uses the compound 5-aza-2-deoxycytidine (5-aza-dC), a DNA methyltrasferase inhibitor. DNA methylation can ... DNA Mapping - The Effect of 5-aza-2-deoxycytidine (5-aza-dC) - A DNA Methyltransferase Inhibitor Presenter. *Amanda Natashia ( ... Method: Colorectal cancer cell line (HCT116) cells treated with or without 5-aza-dC were probed with different antibodies to ... Results: Treatment with 5-aza-dC increased SPARC mRNA levels, and reduced DNA methylation This was associated with changes in ...
Division of AIDS Anti-HIV/OI/TB Therapeutics Database - Surveillance Memo
Ag-SiO2 Nanoparticles: Benign, Expedient, and Facile Nano Catalyst in Synthesis of Decahydroacridines
3-dioxocyclohexane compounds in various media, Chemistry of Heterocyclic Compounds, 2000, 36:403 [Crossref], [Google scholar ... 25]. Gallo S., Atifi S., Mohamoud A., Santelli-Rouvier C., Wolfart K., Molnar J., Barbe J., Synthesis of aza mono, bi and ... In cyclic di-carbonyl compounds the situation of C=O groups concludes completely the effortlessness of their cyclization and ... One of the most investigated types of heterocyclic compounds is decahydroacridine diones. The existence of numerous reaction ...
DailyMed - PIMECROLIMUS cream
Apalutamide | HIF signal
Efficient Synthesis of Bis(3-Methylphenyl)Sulfoxide Aza Macrocycles from a Bis(3-Methylphenyl)Sulfoxide Diester and Diamine...
The structures of these compounds were confirmed using IR, 1H NMR, 13C NMR and Mass spectroscopy. ... sulfoxide aza macrocycles (3-8) were synthesized in high yields based on the conventional methods of the reaction of ... Macrocyclic aza crown compounds have gained a great attention due to their wide applications in chemistry, analysis, ... Bis(3-methylphenyl)sulfoxide aza macrocycles (3-8) were synthesized based on standard procedures shown in Figure 1. Compound 1 ...
NIH Common Fund
Fu created novel aza-β-lactam (ABL) compounds, relatives of penicillin and other β-lactam antibiotics, and provided them to the ... This compound interacts with a protein called S1P1, a receptor on the surface of cells that binds to specific molecules and ... A compound originally identified with the support of the Molecular Libraries program has led to a drug candidate now entering a ... The experimental compound, CB-5083, inhibits a protein called p97 that is critical to many cellular functions, including cell ...
Volatile Organic C1
- Capillary chromatographic analysis of volatile organic compounds in the indoor environment. (cdc.gov)
Organic compounds4
- Industrial hygiene surveys were conducted, and air samples were collected for analysis of polynuclear aromatic hydrocarbons, polynuclear aza heterocyclic hydrocarbons, aromatic amines, metals, common toxic gases, and other organic compounds. (cdc.gov)
- Kinetics and mechanisms of the gas-phase reactions of the hydroxyl radical with organic compounds under atmospheric conditions. (cdc.gov)
- As part of our ongoing program to develop efficient and robust methods for the preparation of heteroatom-containing organic compounds [25-28], we wish to report the synthesis of bis(3-methylphenyl)sulfoxide aza macrocycles derivatives (3-8) from a bis(3-methylphenyl)sulfoxide diester and an aliphathic diamine in methanol reflux with high yields (Figure 1). (samipubco.com)
- In organic chemistry, Nucleosides, Nucleotides, and Analogues are organic compounds containing a nucleobase linked to a ribose or deoxyribose sugar via a beta-glycosidic linkage. (wellnessadvocate.com)
Atoms3
- Macrocyclic compounds analogous to CROWN ETHERS but which lack any OXYGEN atoms. (uchicago.edu)
- The optical properties are compared for two boron dipyrromethene (BODIPY) dyes that differ by virtue of the substituent at the meso-site, namely, aza-N versus C-methine atoms. (ncl.ac.uk)
- In the title compound, C(31)H(39)Br(2)N(3)O(6)S(2), a 17-membered aza-macrocyclic ligand containing two ether O and three aza N atoms, the three pendant aromatic rings form an 'E' shape. (gumushane.edu.tr)
Synthesis5
- 1. Organocatalytic Synthesis of Highly Functionalized Heterocycles by Enantioselective aza-Morita-Baylis-Hillman-Type Domino Reactions. (nih.gov)
- 5. Asymmetric catalytic aza-Morita-Baylis-Hillman reaction for the synthesis of 3-substituted-3-aminooxindoles with chiral quaternary carbon centers. (nih.gov)
- 17. Activated alkene dependent one-pot, three-component aza-Morita-Baylis-Hillman reaction of ferrocenealdehyde: synthesis of highly functionalized diverse ferrocene derivatives. (nih.gov)
- In previous studies, synthesis of dibenzosulfides and dibenzosulfoxides aza macrocycles as metal cations receptors has been reported [23,24]. (samipubco.com)
- It is involved in a number of academic and industrial research programs on multistep synthesis of natural compounds and analogues with potential biological or therapeutic applications. (ic-cgo.fr)
Crown Compounds3
- Crown Compounds" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Crown Compounds" by people in this website by year, and whether "Crown Compounds" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Crown Compounds" by people in Profiles. (uchicago.edu)
Heterocyclic Compounds1
- One of the most investigated types of heterocyclic compounds is decahydroacridine diones. (chemmethod.com)
Sulfur Compounds1
- It is called devil's dung because of its strong pungent smell due to the presence of sulfur compounds. (peppertrail.com)
Alcohols2
- Hydrogen bonding donors, such as alcohols, attach to the aza-N atom and promote nonradiative decay without affecting the properties of the conventional dye. (ncl.ac.uk)
- TfOH-Catalyzed Reaction of Bispropargyl Alcohols with 1,3-Dicarbonyl Compounds. (durham.ac.uk)
Molecular weight2
- Sampling results indicated that workers were exposed to polynuclear aromatic hydrocarbons in the low microgram per cubic meter range, with the light molecular weight compounds in higher concentrations than the four through seven ring compounds. (cdc.gov)
- In our body's living cells, Nucleotides (polynucleotides) & Nucleosides, and nucleic acids are complex compounds of high molecular weight. (wellnessadvocate.com)
Aromatic1
- Aromatic amines, phenolic compounds and simple aromatic solvents were occasionally present at very low levels. (cdc.gov)
Reactions4
- 2. [Development of acid-base organocatalysts for enantioselective aza-Morita-Baylis-Hillman (aza-MBH) reactions via dual activation mechanism]. (nih.gov)
- 8. Trifunctional organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature. (nih.gov)
- 9. Enantioselective, organocatalytic Morita-Baylis-Hillman and Aza-Morita-Baylis-Hillman reactions: stereochemical issues. (nih.gov)
- 20. Palladium-Catalyzed Inverse and Normal Dehydrogenative Aza-Morita-Baylis-Hillman Reactions with γ,δ-Unsaturated Compounds. (nih.gov)
Selective1
- To address this challenge, we now present the rational, iterative development of a general reaction-based trigger utilizing 2-aza-Cope reactivity for selective and sensitive detection of FA in living systems. (nih.gov)
Lead compound2
- The academic approach employed by MLI, in conjunction with the Common Fund's Structural Biology program, allowed for the exploration of basic biological mechanisms that led to the discovery of a lead compound, the crystal structure of S1P1, and the discovery of the binding site for the compound. (nih.gov)
- A new lead compound with specific activity against renal cell carcinoma, which can be synthesized to scale for in vivo studies, and improved oral bioavailability, has been identified. (nih.gov)
Versus1
- In different organic syntheses, these nanoparticles have been mainly employed as nano-catalysts, thanks to their suitable surface area versus their corresponding compounds in bulk form [ 42 - 47 ]. (chemmethod.com)
Reaction9
- Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells. (nih.gov)
- 3. P-chirogenic organocatalysts: application to the aza-Morita-Baylis-Hillman (aza-MBH) reaction of ketimines. (nih.gov)
- 6. An enantioselective organocatalyzed aza-Morita-Baylis-Hillman reaction of isatin-derived ketimines with acrolein. (nih.gov)
- 7. The enantioselective Morita-Baylis-Hillman reaction and its aza counterpart. (nih.gov)
- 10. Highly enantioselective aza Morita-Baylis-Hillman reaction catalyzed by bifunctional beta-isocupreidine derivatives. (nih.gov)
- 15. Chiral N-Phosphonyl Imines for an Aza-Morita-Baylis-Hillman Reaction via Group-Assisted Purification (GAP) Chemistry. (nih.gov)
- 18. New multifunctional chiral phosphines and BINOL derivatives co-catalyzed enantioselective aza-Morita-Baylis-Hillman reaction of 5,5-disubstituted cyclopent-2-enone and N-sulfonated imines. (nih.gov)
- 19. The origin of enantioselectivity in the L-threonine-derived phosphine-sulfonamide catalyzed aza-Morita-Baylis-Hillman reaction: effects of the intramolecular hydrogen bonding. (nih.gov)
- Some bis(3-methylphenyl)sulfoxide aza macrocycles (3-8) were synthesized in high yields based on the conventional methods of the reaction of corresponding bis(3-methylphenyl)sulfoxide diester and diamines in refluxing methanol. (samipubco.com)
Renal1
- Using the maternal LPD rat model, we determined renal excretion of select endogenous compounds by collecting blood and urine at various times of age. (uw.edu)
Chemical2
- Based on its experience in glycochemistry (sugar and iminosugar) the Symbiose group has proposed to develop two families of amphiphilic molecules such as galactosylsphingosine and azasugar compounds, with similar chemical characteristics compared to Edelfosine or Ohmline, that means a polar head and hydrophobic tail. (ic-cgo.fr)
- Quantum chemical calculations indicate that the electronegative aza-N atom lowers the energy of the LUMO while having little effect on the corresponding HOMO energy. (ncl.ac.uk)
Potent1
- One compound named Ohmline has been identified as a potent SK3 channel modulator. (ic-cgo.fr)
DRUGS1
- It was also prescribed as part of several compound drugs in the Hippocratic texts. (peppertrail.com)
Complex1
- Complex compounds in which a dumbbell shaped molecule is encircled by a macrocycle. (uams.edu)
THERAPEUTIC1
- ML probe #341, a compound developed by the NIH Molecular Libraries Probe Production Center at the Broad Institute of MIT and Harvard University, which is part of the NIH Common Fund Molecular Libraries Program, has been chosen for further development by The Global Health Innovative Technology (GHIT) fund as a candidate therapeutic for Chagas disease. (nih.gov)
Methods1
- Compounds, compositions containing such compounds, and methods of using such compound and compositions are described herein. (justia.com)
Biological1
- A preliminary investigation of the biological potential of this compound was conducted using a biomedically relevant target Tel26. (cnr.it)
Activity1
- Prevention of adult emerged and pupal mortality was the main activity of this compound. (who.int)
Parent1
- Parent compounds are effective in in vivo cancer models. (nih.gov)
Family2
- Macrocycles are probably the most widel y used family of host compounds in supramolecular chemistry. (samipubco.com)
- Six species in the insect resistance to neem compounds family Meliacea have been studied for pes- seems likely to be low [ 8-10 ]. (who.int)
Similar1
- Carcinogenic and related properties of compounds structurally similar to 4-methylquinoline. (nih.gov)
Presence1
- the presence of these compounds may represent a skin exposure hazard. (cdc.gov)
Effects1
- Certain compounds, like the plant alkaloid nicotine, interact with all subtypes of the nAChRs, accounting for the profound physiological effects of this compound. (justia.com)
Report1
- According to the lat- compounds have different designations, est report, it kills between 1.5-2.7 million among which azadirachtin A is the major people every year [ 1 ]. (who.int)