An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Inorganic or organic compounds that contain sulfur as an integral part of the molecule.
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Antimetabolites that are useful in cancer chemotherapy.
Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Amidines substituted with a benzene group. Benzamidine and its derivatives are known as peptidase inhibitors.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
Toxic or poisonous substances elaborated by marine flora or fauna. They include also specific, characterized poisons or toxins for which there is no more specific heading, like those from poisonous FISHES.
Compounds containing the -SH radical.
A cell line derived from cultured tumor cells.
Organic compounds which contain tin in the molecule. Used widely in industry and agriculture.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Inorganic compounds that contain nitrogen as an integral part of the molecule.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
The rate dynamics in chemical or physical systems.
Organic compounds which contain selenium as an integral part of the molecule.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
The transference of a kidney from one human or animal to another.
Cyclic compounds with a ring size of approximately 1-4 dozen atoms.
Salts and derivatives of acetoacetic acid.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
Organic chemicals which have two amino groups in an aliphatic chain.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Substances that reduce the growth or reproduction of BACTERIA.
Bacteria which retain the crystal violet stain when treated by Gram's method.

Moxifloxacin: a comparison with other antimicrobial agents of in-vitro activity against Streptococcus pneumoniae. (1/758)

Two hundred representative isolates, including 26 strains of Streptococcus pneumoniae with intermediate resistance to penicillin, were selected from a collection obtained from blood cultures of patients with bacteraemic pneumococcal pneumonia. The MICs of moxifloxacin (BAY 12-8039), grepafloxacin, sparfloxacin, levofloxacin, ofloxacin, ciprofloxacin, erythromycin, tetracycline and penicillin G were determined by a standard agar dilution technique. Moxifloxacin had the highest in-vitro activity against S. pneumoniae (MIC90 = 0.25 mg/L; MIC range 0.06-0.25 mg/L). The MIC90 values were one dilution lower than those obtained with sparfloxacin and grepafloxacin, three dilutions lower than those obtained with levofloxacin, and four dilutions lower than those of ofloxacin and ciprofloxacin.  (+info)

The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus. (2/758)

In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to decreased fluoroquinolone susceptibility. Efflux pumps can be inhibited by the plant alkaloid reserpine, which, at 20 mg/L, reduced sparfloxacin, moxifloxacin and ciprofloxacin IC50s and MICs by up to four-fold in 11, 21 and 48 of the 102 unrelated clinical isolates tested, respectively. The effect was less pronounced with the hydrophobic drugs sparfloxacin and moxifloxacin than with the hydrophilic drug ciprofloxacin and was stable in all 25 clonally related isolates tested.  (+info)

Pharmacokinetics and inflammatory-fluid penetration of moxifloxacin following oral or intravenous administration. (3/758)

A single 400-mg oral or intravenous (i.v.) dose of moxifloxacin was given to each of eight healthy male volunteers, and 6 weeks later the dose was administered by the other route. The concentrations of the drug in plasma, cantharidin-induced inflammatory fluid, and urine were measured over the subsequent 24 h. The mean maximum concentrations observed in plasma were 4.98 microg/ml after oral dosing and 5.09 microg/ml after i.v. dosing. The mean maximum concentrations attained in the inflammatory fluid were 2.62 and 3.23 microg/ml, respectively. The mean elimination half-lives from plasma were 8.32 and 8.17 h, respectively. The overall penetration into the inflammatory fluid was 103.4 and 104.2%. Over 24 h 15% of the drug was recovered in the urine when administered by either route.  (+info)

Comparative in-vitro activities of moxifloxacin, trovafloxacin, quinupristin/dalfopristin and linezolid against staphylococci. (4/758)

The antistaphylococcal activities of four newly developed antibiotics, moxifloxacin (an 8-methoxyfluoroquinolone), trovafloxacin (a naphthyridone), quinupristin/dalfopristin (a semisynthetic streptogramin) and linezolid (an oxazolidinone), were examined and compared with those of ciprofloxacin, vancomycin and teicoplanin, using an agar dilution method. A total of 245 clinical isolates of staphylococci, including a large number of clonally different methicillin-resistant strains, were tested. The new agents tested exhibited wide-spectrum antistaphylococcal activity against both methicillin-susceptible and methicillin-resistant strains. In contrast to the quinolones, the in-vitro activities of quinupristin/dalfopristin, linezolid and the glycopeptides remained almost unchanged, irrespective of the resistance phenotype for methicillin. A number of isolates with elevated quinolone MICs were observed.  (+info)

Comparative susceptibility to penicillin and quinolones of 1385 Streptococcus pneumoniae isolates. Austrian Bacterial Surveillance Network. (5/758)

Antibiotic resistance among Streptococcus pneumoniae isolates has spread rapidly throughout the world since the first description of a strain with diminished susceptibility to penicillin in Australia in 1967. A total of 1385 strains of S. pneumoniae, collected in several centres throughout Austria, were assessed for their sensitivity to moxifloxacin, trovafloxacin, ciprofloxacin, ofloxacin, levofloxacin and lomefloxacin. The MICs were determined using the agar dilution method, according to NCCLS guidelines. Both moxlfloxacin and trovafloxacin showed good anti-pneumococcal activity in terms of MIC50 (both 0.125 mg/L) and MIC90 (both 0.25 mg/L). Less active, but with similar activity to each other, were ciprofloxacin and levofloxacin, each with an MIC50 of 1 mg/L and an MIC90 of 2 mg/L. Ofloxacin showed only moderate activity (MIC50, 1 mg/L; MIC90, 2 mg/L) and lomefloxacin was the least active compound (MIC50, 4 mg/L; MIC90, 8 mg/L). Both moxifloxacin and trovafloxacin at a concentration of < or = 0.5 mg/L inhibited all of the S. pneumoniae strains tested.  (+info)

In-vitro activity of moxifloxacin against fluoroquinolone-resistant strains of aerobic gram-negative bacilli and Enterococcus faecalis. (6/758)

MICs of the new fluoroquinolone, moxifloxacin, and those of ciprofloxacin, ofloxacin and sparfloxacin for 19 genetically characterized fluoroquinolone-resistant strains were determined by the agar dilution method. The MICs of moxifloxacin for Escherichia isolates with one mutation in gyrA (corresponding to Ser83-->Leu or Asp87-->Gly substitution) were 0.25-0.5 mg/L, while those of ciprofloxacin, ofloxacin and sparfloxacin were 0.06-0.25, 1 and 0.12-0.5 mg/L, respectively. These values were four- to 16-fold higher than those of the same antibiotics for the wild-type strain, E. coli KL16. Similar results were observed with clinical isolates of Salmonella spp. harbouring one mutation in gyrA leading to the substitution of Ser83 by Phe or Tyr. In the presence of two mutations in the E. coli gyrA gene, the MICs of moxifloxacin ciprofloxacin, ofloxacin and sparfloxacin were 2, 0.5, 4 and 1 mg/L, respectively; these were 32 times higher than the MICs of these agents for E. coli KL16. The MICs of the four quinolones for triple mutants with two mutations in gyrA and one in parC were even higher, i.e. 8, 8, 16 and 8-16 mg/L, respectively. The MICs of moxifloxacin for Campylobacter coli and Campylobacter jejuni strains with a gyrA mutation leading to Thr86-->Ile substitution ranged from 1 to 2 mg/L, while the MICs of ciprofloxacin, ofloxacin and sparfloxacin were 16-32 mg/L, 8-16 and 4-8 mg/L, respectively. For high-level ciprofloxacin-resistant (MICs of 32 mg/L) clinical isolates of Enterococcus faecalis with one substitution at position 83 in GyrA (E. coli coordinates), the MICs of moxifloxacin, ofloxacin and sparfloxacin were 8-16, > or = 128 and 32 mg/L respectively. In conclusion, moxifloxacin and other fluoroquinolones exhibit cross-resistance against aerobic gram-negative bacilli and enterococci. The in-vitro activity of moxifloxacin was greater than that of ofloxacin and slightly less than that of ciprofloxacin and sparfloxacin against Enterobacteriaceae, but greater than those of the three other compounds tested against Campylobacter spp and E. faecalis.  (+info)

The in-vitro activity of moxifloxacin against Legionella species and the effects of medium on susceptibility test results. (7/758)

The in-vitro activities of moxifloxacin, ciprofloxacin, erythromycin and rifampicin against 49 Legionella spp. isolates were determined by an agar dilution method with buffered charcoal yeast extract agar containing alpha-ketoglutarate. Because the inhibitory effects of charcoal in the test media were pronounced (92% for quinolones, 90.5% for rifampicin and 92.5% for erythromycin), the MICs were corrected for the charcoal-bound fraction of the antibiotics. The corrected geometric mean MICs were 0.018 mg/L for moxifloxacin, 0.02 mg/L for ciprofloxacin, 0.27 mg/L for erythromycin and 0.005 mg/L for rifampicin.  (+info)

The effect of moxifloxacin on its target topoisomerases from Escherichia coli and Staphylococcus aureus. (8/758)

The effect of moxifloxacin on its target enzymes was evaluated by three different approaches: (i) the MICs of moxifloxacin and nine other fluoroquinolones were determined for mutants of Escherichia coli (n = 13) and Staphylococcus aureus (n = 5) carrying different combinations of resistance mutations; (ii) the activity of moxifloxacin on isolated targets was determined as IC50 values for wild-type and mutant type II topoisomerases from E. coli; and (iii) the mutation frequencies were determined for two single-step mutants (MI with a Ser83-->Leu mutation in gyrA and WT-4 with a Ser80-->Ile mutation in parC) and their parent strain (WT). Of the quinolones tested, moxifloxacin was the only one showing an equivalent high activity against both targets. This is reflected by a comparable high susceptibility of the test strains of E. coli and S. aureus and by the IC50 values of moxifloxacin which were 50-90% lower than those of ciprofloxacin, norfloxacin and sparfloxacin for the wild-type and single mutant enzymes of gyrase and topoisomerase IV. However, double mutant GyrA was significantly more sensitive to moxifloxacin than to the other fluoroquinolones tested, while wild-type topoisomerase IV was two-fold more refractory. Mutation rates of WT, MI and WT-4 for ciprofloxacin and moxifloxacin were 5 x 10(-8) vs 4 x 10(-10); <6 x 10(-11) vs <6 x 10(-11); and 2 x 10(-6) vs 5 x 10(-7), respectively. These data indicate an equivalent high inhibitory activity of moxifloxacin on DNA gyrase and topoisomerase IV of E. coli.  (+info)

This placebo-controlled crossover study in healthy volunteers was conducted to evaluate the effect on the QT/QTc interval of i.v. linezolid administered as an infusion at the standard dose of 600 mg and a supratherapeutic dose of 1,200 mg. The tolerability and safety of linezolid observed in the nine subjects in cohort 1 supported the administration of linezolid at 1,200 mg to the larger study population in cohort 2. The study was conducted in accordance with the ICH guidlines on a thorough QT/QTc study (5). On the basis that the upper bound of the two-sided 90% CI was ,10 ms at all time points after the start of infusion of linezolid at both the standard and the supratherapeutic doses, no clinically significant prolongation of the QTcF interval was detected in the present study following linezolid administration. In accordance with the ICH guidance, the present study used moxifloxacin as an active control (5). The population Tmax for moxifloxacin is ∼3 h. Although QTc assessment was not ...
Moxifloxacin reduces infectious complications after cerebral damage, such as ischemia and stroke. This study investigated whether moxifloxacin treatment influences cerebral inflammation and improves cognitive outcome after cardiopulmonary bypass with
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
We described the population pharmacokinetics of moxifloxacin and the effect of high-dose intermittent rifapentine in patients with pulmonary tuberculosis who were randomized to a continuation-phase regimen of 400 mg moxifloxacin and 900 mg rifapentine twice weekly or 400 mg moxifloxacin and 1,200 mg rifapentine once weekly. A two-compartment model with transit absorption best described moxifloxacin pharmacokinetics. Although rifapentine increased the clearance of moxifloxacin by 8% during antituberculosis treatment compared to that after treatment completion without rifapentine, it did not result in a clinically significant change in moxifloxacin exposure.. ...
Moxifloxacin, is being tested at approximately 60 study centres in 15 countries to determine if this drug, when taken periodically in addition to the patients normal treatment, is effective at reducing the number of flare-ups of chronic bronchitis he has. Approximately 1132 subjects will participate, and it is expected that the study will run for 2 years in order to reach that goal. The patients individual involvement in the study will be 17 months. Moxifloxacin will be compared to a placebo drug (no active ingredients). The study medication (moxifloxacin or placebo) will be taken in addition to the patients normal medication for chronic bronchitis. In addition to the first clinic visit, called a screening visit, the patient will be required to come back to the clinic for ten more study visits, every 8 weeks. At the first visit the study co-ordinator will provide him with the dates for all the visits. Over a period of 48 weeks the patient will return to the clinic on 6 occasions where he will ...
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Purpose: To determine if penetrating injury can enhance intraocular penetration of systemic moxifloxacin, vancomycin, and ceftazidime.. Methods: Thirty New Zealand rabbits were divided into 3 groups, 10 rabbits for each of 3 antibiotics. In each group, 5 rabbits were used for scleral injury and 5 for corneal injury. Right eyes were used for injury while left eyes served as controls. For scleral injury, a 4 mm laceration was made 5 mm posterior to the temporal limbus, and for corneal injury, a 3 mm laceration was made in the central cornea. Moxifloxacin 20 mg/kg, vancomycin 15 mg/kg, or ceftazidime 50 mg/kg was administered intravenously 10 minutes after injury. Eyes were enucleated 20 minutes later, frozen, and the vitreous harvested. Intra-cardiac blood was collected before animals were sacrificed. HPLC was performed to determine vitreous and plasma concentration of antibiotics.. Results: Intravitreal moxifloxacin concentration was unchanged by injury (3.34 and 3.28 ug/ml in scleral and corneal ...
they make me feel even sicker than the sikkness.. like theres a nuclear bomb going on inside me. so i looked in wikipedia to see what it was all about.. Moxifloxacin was first patented in 1997 by Bayer A.G. and subsequently approved by the U.S. Food and Drug Administration (FDA) for use in the United States in 1999 to treat severe and life threatening bacterial infections. The licensed uses for moxifloxacin are quite limited as moxifloxacin is to be considered a drug of last resort when all other antibiotics have failed.. Moxifloxacin inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV. Topoisomerases are essential enzymes which play a crucial role in the replication and repair of bacterial DNA. This mechanism is lethal to susceptible bacteria. Moxifloxacin is often referred to as a chemotherapeutic drug because its mode of action has so far not been noted in any naturally occurring or semi-synthetic antibiotic.. i feel as sour as gene simmons looks.. ...
In the Intensive Care (IC)-unit moxifloxacin treatment is often started with intravenous administrations. As moxifloxacin is known to have a high oral bioavailability in healthy volunteers, patients are switched to oral or enteral therapy as soon as possible. However, no data on plasma levels for moxifloxacin during such a switch-therapy in IC-patients are available. Therefore, this study aims to evaluate the moxifloxacin-plasma levels and their inter-individual variability during IV to enteral switch therapy in IC-patients ...
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This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you take this medicine. Moxifloxacin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop taking this medicine. Do not take any medicine to treat diarrhea without checking first with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor. Tell your doctor right away if you start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy. Moxifloxacin may rarely cause inflammation (tendinitis) or tearing of a tendon (the cord that ...
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Moxifloxacin by Pro Doc: Moxifloxacin is an antibiotic that belongs to the group of medications known as quinolones. It is used to treat infections caused by certain bacteria.
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Avelox (moxifloxacin) effectively treats different types of bacterial infections, but is more expensive than its alternatives. People with diabetes need to check their blood sugar levels regularly while taking Avelox (moxifloxacin).
At the meeting in Denver, Dr. Gelles and I presented a case of a patient whose PED was managed with scleral lenses.. A 64-year-old man with diabetes presented with a PED that was present for 3 months after complicated cataract surgery in his right eye. He was monocular and had a prosthesis in his left eye. The right eye demonstrated evidence of neurotrophic keratitis secondary to a herpes simplex virus infection. Significant exposure keratitis and a PED were present in the right eye. Previous management strategies included topical moxifloxacin, three discrete treatments with cryopreserved amniotic membrane (Prokera, BioTissue), a bandage contact lens that frequently dislocated, autologous serum drops every 30 minutes, nighttime lubricant ointment, and a tape tarsorrhaphy at night.. Two scleral lenses were prescribed, and the patient was instructed to swap them every 12 hours. The patient was instructed to apply one drop of moxifloxacin and two drops of autologous serum in the bowl of the lens, ...
Avelox (Moxifloxacin HCL) is an antibiotic drug, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related ...
Author: Allen Loyd V, Year: 2015, Abstract: A formulation for preparing Moxifloxacin Hydrochloride 1.6-mg/mL Intravenous Injection. Includes ingredients, method of preparation, discussion, and references for the compounding pharmacist.
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Easy to read patient leaflet for Moxifloxacin (Ophthalmic). Includes indications, proper use, special instructions, precautions, and possible side effects.
An ophthalmic drop formulation of dexamethasone 0.1%/moxifloxacin 0.5% was developed by Alcon (a division of Novartis) for the treatment of ocular inflammation
Detailed drug Information for moxifloxacin Ophthalmic. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
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Buy Avelox Online! Avelox contains the active substance Avelox, which belongs to a group of antibiotics called fluoroquinolones. Avelox works by killing bacteria that cause infections.
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The purpose of this study is to evaluate the efficacy, safety and pharmacokinetics of intravenous nemonoxacin [Taigexyn] compared with intravenous moxifloxacin
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PURPOSE: To assess the effectiveness of adding topical moxifloxacin 0.5% to topical povidone-iodine 5.0% for preoperative reduction of bacterial recovery from the conjunctiva. SETTING: Emek Medical Center, Afula, Israel. METHODS: The study population
Moxifloxacin is a new broad-spectrum antibacterial agent for treatment of respiratory tract infection of pathogens, including the major pathogens isolated in respiratory tract infections. The pharmacokinetic and pharmacodynamic properties of moxifloxacin are: excellent bioavailability, long half-life, and superior tissue penetration. Consequently, the 90% minimum inhibitory concentration (MIC90) values exhibited by moxifloxacin are generally lower than the concentrations of moxifloxacin found in circulation and in pulmonary tissues after a standard 400-mg dose given for up to 30 h. The relationship between moxifloxacin MIC90 values and clinical response was investigated. The results of 13 clinical trials, performed in 30 countries between 1997 and 1998 and comprising 2618 patients treated with moxifloxacin or a comparator drug, were reviewed. Overall, 94% clinical success and 95% bacterial eradication was observed with moxifloxacin. These results were equivalent or superior to results seen with ...
Product Name: Moxifloxacin Hydrochloride Ohthalmic Solution Common Name: anti-infective eye drops. Strength: 0.5% w/v. Description: Moxifloxacin hydrochloride ophthalmic solution 0.5% is a sterile solution for topical ophthalmic use. Moxifloxacin hydrochloride is an 8-methoxy fluoroquinolone anti-infective, with a diazabicyclononyl ring at the C7 position.. Indications and Usage:. Moxifloxacin hydrochloride ophthalmic solution is a topical anti-infective eye drop used to treat bacterial conjunctivitis or other bacterial infections of the eyes.. Pack Size: Moxifloxacin Hydrochloride Ohthalmic Solution is available in 5ml & 10ml plastic dropper bottle.. Minimum Order Quantity: 3000 packs. Certification: WHO-GMP. ...
Background/aims: The clearance of moxifloxacin is reported to be unaltered in the presence of renal insufficiency. There is little information about the clearance of intravenous moxifloxacin in renal replacement therapies during intensive care. The aim of this study was to determine the clearance of moxifloxacin during continuous veno-venous haemofiltration (CVVHF) in vitro.. Methods: The elimination of moxifloxacin (reservoir with 600 mL of washed human erythrocytes, 100 mL of NaHCO3 and various amounts of Ringer solution and human albumin to give a total volume of 1000 mL, pH 7.35 ± 0.5; haematocrit 41 ± 2) during CVVHF in vitro with two filter conditions (during priming, after priming), three protein concentrations (human albumin: 0 g/L, 20 g/L, 40 g/L) and two filtration velocities [(i) standard condition: blood flow at 100 mL/min and turnover of 2 L/h; (ii) blood flow at 50 mL/min and turnover of 1 L/h] were investigated.. Results: A new filter needs 20 min of priming before moxifloxacin ...
Corneal healing using 0.5% moxifloxacin monotherapy is equivalent to that of combination therapy using fortified cefazolin and tobramycin in the treatment of moderate bacterial corneal ulcers. ...
Purpose : Post-operative endophthalmitis (POE) is an uncommon yet potentially devastating complication of cataract surgery. The landmark study by the European Society of Cataract and Refractive Surgeons (ESCRS) clearly demonstrated the benefit of intracameral antibiotic prophylaxis in reducing the incidence of POE. However, it only tested one antibiotic at one concentration. The advent of fourth-generation fluoroquinolones, including Moxifloxacin, have since shown to be the most effective broad-spectrum topical antibiotics. Here, we seek to evaluate the efficacy and liabilities of the available prophylactic intracameral antibiotics, and to devise an optimum dosing and administration protocol for intracameral moxifloxacin. Methods : Retrospective review of all cataract surgical cases, performed sequentially by the senior author (S.A.A.), using clear corneal incisions, with no cases excluded. The rates of POE using Intracameral vancomycin were compared with that of intracameral moxifloxacin ...
Choice of baseline in a multiple-dose thorough QT study (TQTS) – effect on analysis of moxifloxacin-induced QTc prolongation B Tyl1, S Azzam2, E Reinbolt2, N Blanco1, J Olbertz3, W Wheeler11MDS Pharma Services, Centralized Cardiac Services, Baillet-en-France, France; 2MDS Pharma Services, Early Clinical Research, Lincoln (Nebraska), USA; 3MDS Pharma Services, Early Clinical Research, Phoenix (Arizona), USABackground: The primary endpoint of a thorough QT study (TQTS) is the change from baseline in QT corrected (QTc) measured on electrocardiograms (ECG) tracings. It has been suggested that during a crossover study, the time-matched or predose baseline could be recorded. The choice of method for baseline ECG collection may influence the results and the cost of the TQTS.Objective: The objective of our study was to compare the collection of a time-matched baseline before each period (TMEACH), an average of all the time-matched baseline (TMMEAN), a time-matched baseline before period 1
Moxifloxacin is used for treating certain types of bacterial infections in adults. This eMedTV resource discusses moxifloxacin uses in more detail, explores the risk of using this antibiotic in children, and lists possible off-label uses for the drug.
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Page 9: Novel Laboratories, Inc.: Moxifloxacin hydrochloride is a fluoroquinolone antibacterial indicated for treating infections in adults 18 years of age and...
A 51-year-old man with a medical history of mild osteoarthritis went to the emergency department for the evaluation of worsening, bilateral injected, painful eyes of 1-month duration associated with the development of a nonproductive cough and nonexertional chest pain for 1 week. He had been treated with topical moxifloxacin for conjunctivitis without improvement 3 weeks before presentation. Subse...
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Animal reproductive and development studies were done in rats, rabbits and cynomolgus macaques. Moxifloxacin was not teratogenic when administered to pregnant rats during organogenesis (gestation days 6 to 17) at oral doses as high as 500 mg/kg/day or 0.24 times the maximum recommended human dose based on systemic exposure (AUC), but decreased fetal body weights and slightly delayed fetal skeletal development were observed. Intravenous administration of 80 mg/kg/day (approximately 2 times the maximum recommended human dose based on body surface area) to pregnant rats resulted in maternal toxicity and a marginal effect on fetal and placental weights and the appearance of the placenta (Gestation days 6 to 17). There was no evidence of teratogenicity at intravenous doses as high as 80 mg/kg/day (approximately 2 times the maximum recommended human dose based on body surface area) in pregnant rats during organogenesis (Gestation days 6 to 17). Intravenous administration of 20 mg/kg/day (approximately ...
Moxifloxacin is an antibiotic. One brand is Avelox, which is used to treat lung and sinus infections. An 0.5% solution marketed as Vigamox is used to treat bacterial conjunctivitis (pinkeye).
Moxifloxacin + Tobramycin in Assamese - ৰ ব্যৱহাৰ, পালি, পাৰ্শ্চক্ৰিয়া, উপকাৰ, ক্ৰিয়া-প্ৰতিক্ৰিয়া আৰু সতৰ্কতাবাণী বিচাৰি উলিয়াওক।
Buy Mosi Online! Mosi is a fluoroquinolone antibiotic medicine used to treat certain types of infections caused by certain germs called bacteria in adults 18 years or older. Examples include viral infections in the sinuses and lungs, such as the common cold or flu.
Andre regimer kan foreslås i udvalgte tilfælde, men dette bør altid aftales med den klinisk mikrobiologiske afdeling efter resistensbestemmelse. * Der anvendes EUCAST-grænseværdier (breakpoints). For de non-hæmolytiske streptokokker anvendes EUCAST pneumokok breakpoints for moxifloxacin og rifampicin. ** Der er ikke defineret noget EUCAST breakpoint for E. faecalis og moxifloxacin. Der anvendes S: MIC ≤ 0.5 mg/l. Det er op til den enkelte klinisk mikrobiologiske afdeling, hvilken metode man anvender til resistensbestemmelse af de enkelte antibiotika. *** Ikke markedsført, men kan med udleveringstilladelse fra Lægemiddelstyrelsen rekvireres fra apotek eller sygehusapotek. ...
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Moxifloxacin Decarboxy Analog ;. Decarboxy Moxifloxacin HCl ;. 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline HCl ;. CAS # 1322062-57-6 (base) ;. C20H24FN3O2 (base) ; MW: 357.42 ;. C20H25ClFN3O2 (HCl salt) ; MW: 393.88 ;. Supplied as HCl salt ;. ...
N-Methyl Moxifloxacin HCl ;. 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-1-methyl-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride ;. CAS # 721970-37-2 & 1179992-99-4 (Base) ; 1350716-67-4 (HCl Salt) ;. C22H27ClFN3O4 ;. MW: 451.92 ;. ...
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Aza-steroids. Part VII. 3-aza-A-homopregn-4a-ene and related compounds". Journal of the Chemical Society (Resumed): 3388. doi: ...
... (AzA) is an organic compound with the formula HOOC(CH2)7COOH. This saturated dicarboxylic acid exists as a white ... In comparative review of effects of topical AzA, Salicylic acid, Nicotinamide, Sulfur, Zinc, and alpha-hydroxy acid AzA enjoyed ... Along with retinoids AzA is considered to be effective in improving acne-treatment results. The studies of latter though were ... AzA inhibits tyrosinase. Azelaic acid is industrially produced by the ozonolysis of oleic acid. The side product is nonanoic ...
Silicon-nitrogen compounds with alternating silicon- ("sila") and nitrogen atoms ("aza") are designated as silazanes. Simple ... the compound would actually be named poly[aza(dimethylsilylene)], and according to the preliminary rules for inorganic ... After compounding, casting and curing, the thermoset material can be pyrolyzed in one step to give a ceramic component in high ... macromolecules catena-poly[(dimethylsilicon)-m-aza]. The labels normally used to describe the structure of silicones (M, D, T, ...
Bi- and tri-cyclic aza compounds and their uses U.S. Patent 6,150,376 WO 0007994 ɑIC50 for displacement of [3H]cocaine. IC50 ... 1R,2S,10R,12S)-15-methyl-15-azatetracyclo(10.2.1.0²,¹⁰.0⁴,⁹)pentadeca-4(9),5,7-trien-3-one Parent compound of a series of ... N.B. In the case of both nocaine and pethidine, N-demethyl compounds are more toxic and have a decreased seizure threshold. ... Therefore it is to be expected that within different contexts a compound or chemical of the same name very possibly could be in ...
The word Azakhel Payan is a linguistic compound consisting of three words. Aza is probably the name of its founder. The word ... Instead, the name Aza Khel may derive from Za Khel, a town in Kondoz, Afghanistan. Azakhel Payan has a complex and ambiguous ... According to one theory, the name Aza Khel was given to the village by its founder. The founder may have been Raza Khan. Raza ... Khan, also spelled Aza Khan, is considered a legendary Afghan warrior.[by whom?] Raza Khan had seven brothers, one of whom was ...
... to form various N-heterocyclic compounds through the aza-Diels-Alder reaction. Nitroso compounds (R-N=O) can react with dienes ... Bradsher cycloaddition Wagner-Jauregg reaction Imine Diels-Alder reaction Aza-Diels-Alder reaction Kloetzel, M. C. (1948). "The ... "Organometallic Compounds and Homogeneous Catalysis". Ullmann's Encyclopedia of Industrial Chemistry. doi:10.1002/14356007.a18_ ...
In one study, a [4.5.5.5]fenestrane was synthesized with one carbon atom replaced by nitrogen because aza- compounds and their ... A fenestrane in organic chemistry is a type of chemical compound with a central quaternary carbon atom which serves as a common ... They can be regarded as spiro compounds twice over. Because of their inherent strain and instability, fenestranes are of ... salts are more likely to form crystalline compounds suitable for X-ray analysis than low-molecular-weight alkanes. In step 1 ...
In addition, aza-Friedel-Crafts reactions of furans, amidoalkylations of diazocarbonyl compounds, asymmetric ... For example, in a typical acyl substitution reaction, the starting carbonyl compound is coordinated to the catalyst through one ... Furthermore, analogous reactions involving oxyanion intermediates such as enolate addition to nitroso compounds or opening of ... attractive strategy since the anionic tetrahedral intermediates are better hydrogen-bond acceptors than the starting compound. ...
This compound serves as a building block for macrocyclizations. Many kinds of aza crown ethers exist. Variable length linkers ... In chemistry, an aza-crown ether is an aza analogue of a crown ether (cyclic polyether). While the parent crown ethers have the ... 2.2.2-Cryptand is an aza-crown of the mixed ether-amine variety. The synthesis of aza crown ethers are subject to the ... Cryptands, three-dimensional aza crowns, feature tertiary amines. Mixed ether-amine ligands Another large class of macrocyclic ...
... hence the prefix aza does not imply an aza compound, but refers to the scientific species name). Many more compounds, related ... Azadirachtin, a chemical compound belonging to the limonoid group, is a secondary metabolite present in neem seeds. It is a ... Hence, the first total synthesis was published over 22 years after the compound's discovery: this first synthesis was completed ... Because pure neem oil contains other insecticidal and fungicidal compounds in addition to azadirachtin, it is generally mixed ...
The prefix aza- is used in organic chemistry to form names of organic compounds where a carbon atom is replaced by a nitrogen ... While the above figure gives examples of 4-aza steroids, 6-aza steroids have also been developed by GSK, although none of these ... compounds, as yet, are available for sale commercially. IUPAC nomenclature of organic chemistry Principles of Chemical ...
DEAD is an aza-dienophile and an efficient dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides and ... Safety hazards have resulted in rapid decline of DEAD usage and replacement with DIAD and other similar compounds. Diethyl azo ... It has also been used to generate aza-Baylis-Hillman adducts with acrylates. DEAD can be used for synthesis of heterocyclic ... Thus, in general DEAD is an aza-dienophile and dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides ...
... although other silver and copper compounds have been used. This added step allows for more precise control of iminium ion ... Thus the 3-aza Cope's large activation barriers are kinetically based. Research on both the 1 and 3-aza-Cope rearrangements has ... The 3-aza-Cope rearrangement (and thus also the 1-aza-Cope rearrangement, which goes through the same transition state) is ... The 3-aza-Cope reaction was discovered soon after the 2-aza-Cope rearrangement was identified, due to its analogous ...
A tosylimine reacts with an α,β-unsaturated carbonyl compound to an allylic amine in the Aza-Baylis-Hillman reaction. ... When R = H, the compound is a primary imine, when R is hydrocarbyl, the compound is a secondary imine. Imines exhibit diverse ... An imine (/ɪˈmiːn/ or /ˈɪmɪn/) is a functional group or chemical compound containing a carbon-nitrogen double bond. The ... a b Fletcher, Dermer, Fox, Nomenclature of Organic Compounds (1974) doi:10.1021/ba-1974-0126.ch023 ...
... β-unsaturated carbonyl compound to an allylic amine in the Aza-Baylis-Hillman reaction. Imines are intermediates in the ... When R = H, the compound is a primary imine, when R is hydrocarbyl, the compound is a secondary imine. Imines exhibit diverse ... Alternately, an imine is named as a derivative of a carbonyl, adding the word "imine" to the name of a carbonyl compound whose ... In the older literature, imine refers to the aza analogue of an epoxide. Thus, ethyleneimine is the three-membered ring species ...
The more recent x-ray crystal structure of 1-aza-3,5,7-trimethyladamantan-2-one is a good model for cationic tetrahedral ... compounds with sulfur atoms bonded to the anomeric centre (e.g. S-acylated-1,8-naphthalenedithiol) These compounds were used to ... compounds with a strong electron-withdrawing group attached to the acyl carbon (e.g. N,N-dimethyltrifluoroacetamide) compounds ... 3.0.co;2-u. Bell, R. P. (1966). "The reversible hydration of carbonyl compounds". Adv. Phys. Org. Chem. Advances in Physical ...
Aromatic compounds can also react in DAINV reactions, such as triazines and tetrazines. Other common classes of dienes are oxo ... and aza- butadienes. The key quality of a good DAINV diene is a significantly lowered HOMO and LUMO, as compared to standard DA ... DAINV reactions have been utilized for the synthesis of several natural products, including (-)-CC-1065, a parent compound in ... DAINV reactions often involve heteroatoms, and can be used to form heterocyclic compounds. This makes the DAINV reaction ...
... (1,4,8,11-tetraazacyclotetradecane) is an organic compound with the formula (NHCH2CH2NHCH2CH2CH2)2. Classified as an aza ... The compound was first prepared by the reaction of 1,3-dibromopropane and ethylenediamine. The compound features four secondary ...
... or imidazo[1,2-a][1,3,5]triazine is a heterocyclic aromatic organic compound that consists of a s-triazine ... However, in 5-aza-7-deazapurine, N-9 of five-membered ring does not bond with hydrogen. So 5-aza-7-deazapurine derivatives must ... 5-Aza-7-deazapurine nucleosides may have an oxo, thioxo, or a imine group. Notable derivatives of this molecule include 5-aza-7 ... "5-Aza-7-deazaguanine DNA: Recognition and Strand Orientation of Oligonucleotides Incorporating Anomeric Imidazo[1,2-a]-1,3,5- ...
Jurkschat, K.; Tzschach, A. (1984). "1-Aza-5-stanna-5,5-dimethylbicyclo[3.3.01,5] octan und 1-aza-5-stanna-5-methyltricyclo[3.3 ... Evidence for a transannular donor−acceptor interaction in a tetraorganotin compound". Journal of Organometallic Chemistry. 315 ... A stannatrane (IUPAC: 1-aza-5-stannabicyclo[3.3.3]undecane) is a tin-based atrane belonging to the larger class of ... largest known value for any existing tetraorganotin compounds); (3) the observation of unusual hybridization at the apical tin- ...
... and on-site feed and medical compounds. The zoo became an institutional member of the AZA in 1957. In 1965 Paul S. Chaffee was ... aza.org. AZA. Retrieved 27 June 2011. "Zoos and Aquariums of the World". waza.org. WAZA. Retrieved 27 June 2011. "Species". ... The zoo is accredited by the Association of Zoos and Aquariums (AZA) and is a member of the World Association of Zoos and ... AZA) officially recognized the park opening in 1929 as the Roeding Park Zoo. Only few animals were seen, but that number would ...
... to give an allylic alcohol Aza-Baylis-Hillman reaction, the reaction of an α,β-unsaturated carbonyl compound with an imine in ...
Carborane Lenka Schneider, Ulli Englert, Peter Paetzold (1994). "Die Kristallstruktur von Aza‐closo‐decaboran NB9H10". Z. Anorg ... Azaboranes can also refer to simpler compounds including iminoboranes (formula = RN=NR') and borazines. ...
... the universal precursor for monoterpenoid indole alkaloid compounds. It also catalyses the formation of 12-aza-strictosidine, ... One such investigation found (21S)-12-aza-nacycline, a 12-aza-strictosidine derivative, to exhibit potent cytotoxicity to the ... Unlike the mechanisms behind the formation of several Pictet-Spengler compounds, a spiroindolenine intermediate containing a ... an important intermediate for cytotoxic alkaloids, from coupling secologanin with 7-aza-tryptamine. The enzyme is encoded by a ...
It is used as a reagent in the production of many organic compounds. It is often used in the Mitsunobu reaction, where it ... It has also been used to generate aza-Baylis-Hillman adducts with acrylates. It can also serve as a selective deprotectant of N ... One notable use of this compound is in the synthesis of Bifenazate (Floramite®).[citation needed] "luka DIAD on Sigma-Aldrich ... CS1 maint: discouraged parameter (link) Shi, Min; Zhao, Gui-Ling (2004). "Aza-Baylis-Hillman reactions of diisopropyl ...
It can also be used as a precursor for (5-aza-2′-Deoxycytidine) a treatment for MDS patients. This compound can slows the cell ...
As for carbon compounds, catalysed Michael additions and aldol reactions can be used. For aromatic nitro compounds, synthesis ... or the aza Diels-Alder reaction catalytic synthesis. Again, water can be used as a solvent, and high yields can be achieved ... The compounds are hygroscopic, so care is required for storage and handling. However, these considerations also apply to the ... Pyridine compounds are common in biology and have many applications. Normally, pyridine is synthesized from acetaldehyde, ...
One approach is to inhibit the methylation of the Sod2 and MMP-9. The DNMT inhibitors 5-azacytidine and 5-aza-20-deoxycytidine ... compounds which increase learning may also increase re-consolidation, ultimately strengthening the memory. A number of cardiac ... The DNMT inhibitors 5-azacytidine and 5-aza-20-deoxycytidine mentioned above have both been approved by the FDA for the ... and studies have examined the effects of those compounds on diabetic retinopathy, where they seem to inhibit these methylation ...
... , also known as 17β-(N-tert-butylcarbamoyl)-4-aza-5α-androst-1-en-3-one, is a synthetic androstane steroid and 4- ... As an unconjugated steroid, finasteride is a highly lipophilic compound. In 1942, James Hamilton observed that prepubertal ... 4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase ...
"Compound discovered at Sanford Burnham Prebys advances into Phase 1 trial for pancreatic cancer , SBP". "Cancer Drug ... Pang, HB; Braun, GB; Friman, T; Aza-Blanc, P; Ruidiaz, ME; Sugahara, KN; Teesalu, T; Ruoslahti, E (2014). "An endocytosis ... "Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors". Cancer Cell. 16 (6): 510-520. doi:10.1016/j.ccr. ... systemic delivery of imaging and therapeutic compounds into acute brain injuries". Nat Commun. 7: 11980. doi:10.1038/ ...
AZA (Association of Zoos and Aquariums) Aquatic Invertebrate Taxonomic Advisory Group in association with AZA Animal Welfare ... The scientific Latin term octopus was derived from Ancient Greek ὀκτώπους or ὀκτά-, a compound form of ὀκτώ (oktō, "eight") and ...
Possible drug candidates were then synthesized from that compound and screened for activity. One of these compounds was active ... 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and ( ... The earliest compounds were ions, such as bromide. Barbiturates[edit]. In 1903, the first psychoactive derivative of barbituric ... He thought the compound had a heptoxdiazine structure (Figure 7) but it was later determined to be a quinazoline-3-oxide. ...
Examples include compounds based on the 1-Ethyl-3-methylimidazolium (EMIM) cation and include: EMIM:Cl, EMIM dicyanamide, (C. 2 ... Aza-Baylis-Hillman reaction for the use of a chiral ionic liquid in asymmetric synthesis. ... Saturated aliphatic compounds are generally only sparingly soluble in ionic liquids, whereas olefins show somewhat greater ... They offer the specificity required to separate similar compounds from each other, such as separating polymers in plastic waste ...
Reduction of nitro compounds Nitro compounds Can be accomplished with elemental zinc, tin or iron with an acid. ... Aza-Baylis-Hillman reaction Imine Synthesis of allylic amines Birch reduction Imine Useful for reactions that trap unstable ... ˈæmiːn/,[1][2] UK also /ˈeɪmiːn/)[3] are compounds and functional groups that contain a basic nitrogen atom with a lone pair. ... Aryldiazonium couple with electron-rich aromatic compounds such as a phenol to form azo compounds. Such reactions are widely ...
AZA. Khan and colleagues have demonstrated a potential role for neuroglobinin attenuating amyloid-related neurotoxicity.[76] 5- ... Histone deacetylase (HDAC) inhibitors are the main compounds that have been tested to increase SMN2 mRNA expression. Inhibiting ... aza-2' deoxycitidine (AZA, or decitabine), a DNMT inhibitor, has shown some evidence for regulating neuroglobin expression, ...
עַזָּה‎, Modern: Aza, Tiberian: ʿAzzā Ancient Ġāzā), also referred to as Gaza City, is a Palestinian city in the Gaza Strip, ... and furan compounds.[161] ... The Hebrew name of the city is Aza (עזה) - the ayin at the ...
1988). Chemistry and biology of naturally-occurring acetylenes and related compounds (NOARC): proceedings of a Conference on ... Ordezkapena gertatu den posizio hauek aza- aurrizkiaren bidez adierazten dira.. Kate nagusia aukeratu eta zenbatzeko, alkoholen ... A Guide to IUPAC Nomenclature of Organic Compounds, Recommendations 1993, Oxford: Blackwell Scientific Publications, 1993 ... R-5.6.1, Aldehydes, thioaldehydes, and their analogues, A Guide to IUPAC Nomenclature of Organic Compounds: recommendations ...
The compound provides real time near-infrared (NIR) fluorescence imaging with an extinction coefficient of 2.8 × 105 M−1 cm−1 ... Phthalocyanines (PCs) are related to tetra-aza porphyrins. Instead of four bridging carbon atoms at the meso-positions, as for ... In porphyrin systems, the zinc ion (Zn2+) appears to hinder the photodynamic activity of the compound. By contrast, in the ... A photosensitizer is a chemical compound that can be promoted to an excited state upon absorption of light and undergo ...
cellular response to organic cyclic compound. • natural killer cell activation. • negative regulation of I-kappaB kinase/NF- ... 2c2z: CRYSTAL STRUCTURE OF CASPASE-8 IN COMPLEX WITH AZA-PEPTIDE MICHAEL ACCEPTOR INHIBITOR ...
... (IUPAC name: phosphinine) is a heavier element analog of pyridine, containing a phosphorus atom instead of an aza- ... Structural studies by electron diffraction reveal that phosphorine is a planar aromatic compound with 88% of the aromaticity of ... Phosphorine undergoes electrophilic substitution reactions like ordinary aromatic compounds: bromination, acylation, and so on ...
The parent compound name can be altered in two ways. *For many common compounds the substituent is linked at one end (the 1 ... The suffix -yl is used when naming organic compounds that contain a single bond replacing one hydrogen; -ylidene and -ylidyne ... The use of the suffix is determined by the number of hydrogen atoms that the substituent replaces on a parent compound (and ... in compound names. Several reforms of chemical nomenclature eventually generalized the use of the suffix to other organic ...
Tatsumi M, Groshan K, Blakely RD, Richelson E (1997). „Pharmacological profile of antidepressants and related compounds at ... Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers". ...
Organic compound aniline, polymerized into long chains in a phytic acid solution, was freeze-dried into a stable, mesoporous ... AZA Battery claims to have developed cells with characteristics suitable for both stationary storage and mobility applications. ...
Baldwin, S. W.; Doll, T. J. (1979). "Synthesis of the 2-aza-7-oxatricyclo[4.3.2.04,8]undecane nucleus of some gelsemium ... This result suggested that there is a high selectivity for the 3° hydrogen, but the intermediate tertiary chloro compound 17 is ... Synthesis of 1,4-epimine compounds". J. Org. Chem. 48 (23): 4430-4432. doi:10.1021/jo00171a066. De Armas, P.; Carrau, R.; ... Esposito, G.; Furstoss, R.; Waegell, B. (1971). "Synthese de la methyl-6, aza-6, bicyclo (3,2,1) octanone-4". Tetrahedron Lett ...
... concluded in a consensus paper in 2010 that while AZA and mercaptopurine have an FDA rating of D, new research in both animals ... Thiocarbonyl compounds. *IARC Group 3 carcinogens. *Purine antagonists. *World Health Organization essential medicines ... leading to the US FDA rating both AZA and mercaptopurine as category D drugs. However, Davis et al. 1999 found mercaptopurine, ...
... , also known as N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide, is a synthetic ... Trifluoromethyl compounds. Hidden categories: *Template:drugs.com link with non-standard subpage ... GG-745; GI-198745; GI-198745X; N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide. ...
Andrade, AR; Barros, LL; Azevedo, MFC; Carlos, AS; Damião, AOMC; Sipahi, AM; Leite, AZA (3 April 2018). "Risk of thrombosis and ... Many 5-ASA drugs have been developed with the aim of delivering the active compound to the large intestine to maintain ...
... and aza-bicyclo[2,1,1]hexanes". J. Chem. Soc. D. 19: 1167. doi:10.1039/C29710001167. Corey, E. J.; Kang, M. C.; Desai, M. C.; ... many intramolecular reactions that would not occur as an intermolecular reaction between two compounds take place. Examples of ... reactions have been used to synthesize organic compounds with interesting ring systems and topologies. For example, [2+2] ...
Through a four-membered transition state, N2 is lost to form an aza-ylide. The unstable ylide is hydrolyzed to form phosphine ... and it has also been used in the generation of SPECT imaging compounds. More recently, the use of an oxanorbornadiene was ... However, this reaction is not immediately bioorthogonal because hydrolysis breaks the covalent bond in the aza-ylide. The ... The reaction must be selective between endogenous functional groups to avoid side reactions with biological compounds ...
CYP1A1 is a protein that is well known for its role in chemical compounds and drug metabolism. A study in prostate cancer ... may try to decrease CpG methylation by using a drug that works as DNA methytransferase inhibitor such as decitabine or 5-aza-2 ... alkylguanine in DNA to itself to fight against mutagenesis and the buildup of toxic compounds that result from alkylating ... and understand drug response to treatments such as target compounds, traditional chemotherapy agents, and epigenetic drugs. ...
Treatment of these compounds with TBAF invokes a ring-expansion that provides the corresponding benzazepines. One variation of ... The reaction is also classified as a subset of aza Diels-Alder reactions The reaction depicted in Scheme 2 illustrates the ... The imine in this organic reaction is a condensation reaction product from an aniline type compound and a benzaldehyde type ... a dirhodium catalyst effects diazo decomposition from silyl enol ether diazo compound to yield a donor/acceptor cyclopropene. ...
The Kirsanov reaction is a method for the synthesis of certain organophosphorus compounds. In this reaction a tertiary ... Eguchi, Shoji; Matsushita, Yuji; Yamashita, Keizo (April 1992). "The Aza-Wittic Reaction in Heterocyclic Synthesis. A Review". ...
2016 He was also part of MAchar AZA #1887 in the organization BBYO San Francisco Gate: "Marc Benioff, CEO, makes philanthropy a ... 6.5 billion fortune and owns a 5-acre compound in Hawaii". Wired. Business Insider. ISSN 1059-1028. Retrieved January 5, 2020 ...
... β-unsaturated carbonyl compound, with an imine in the presence of a nucleophile. The reaction product is an allylic amine. The ... The aza-Baylis-Hillman reaction or aza-BH reaction in organic chemistry is a variation of the Baylis-Hillman reaction and ... Aza-BH reactions are known in asymmetric synthesis by making use of chiral ligands. In one study, for the first time, ... Because this step is also reversible the presence of acid causes a racemisation process simply by mixing chiral aza-BH adduct, ...
It is a potent α2-adrenergic receptor antagonist with ~10x the strength of the related compound mianserin and has also been ... for alpha 2-adrenoceptor blockade in the central nervous system and the effects of the enantiomers of mianserin and its aza- ...
... one of the pioneers of NMR as a tool to study organic compounds, winner of the National Medal of Science (1990) and the ... statistician Aza Raskin, graduate studies, design expert, interface guru, and entrepreneur Huck Seed, undergraduate studies, ... known for contributions to chemical vapor deposition of compound semiconductors Mark Kushner, PhD 1979; George I Haddad ...
The ligand and its coordination compounds are formulated according to the chemical analysis, electronic, infrared, ,sup,1,/sup, ... and its new-fangled complex compounds of the general formula [M-L Cl,sub,2,/sub,] for M= Ru(III), and [M-L] for Pt(II) and Pd( ... Synthesis and Characterization of Complex Compounds of Tetra-aza Macrocyclic Ligand. Mayura A. Panchbhai,1 L. J. Paliwal. ,2 ... Synthesis and Characterization of Complex Compounds of Tetra-aza Macrocyclic Ligand,. Journal of Chemistry,. vol. 5. ,. ...
This report presents the findings that in 1994 at least 0.5% of infants in Georgia (US) had had perinatal exposure to cocaine ...
aza-. cyclopenta(b)fluorene-. 1,9-. dione 10-. (5-. nitro-. furan-. 2-. yl)-. 2,3,4,10-. tetrahydro-. 4-. aza-. cyclopenta(b) ... aza-. bicyclo(4,3,0)nonane-. 9-. carboxylic acid 3-. (2-. cyclopropyloxy-. 5-. trifluoromethoxyphenyl)-. 6-. phenyl-. 1-. oxa- ... aza-. 5-. iodo-. 3-. oxa-. 4-. phenylbicyclo(4.4.0)decane-. 2,8-. dione ... Aza Compounds Equivalent Term Compounds, Aza Definition Organic chemicals where carbon atoms have been replaced by nitrogen ...
Reductive amination of this dione, using sodium borohydride, yielded the aza-triquinylamines. Aza-cage compounds were also ... An interesting observation made with all the aza-bridgehead compounds as well as with NGP1-01, was their tendency to increase ... Identification of the compounds was achieved by means of Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS) and Infrared ... An additional compound, the lactol derivative of the triquinanes, was synthesised by reducing the triquinane dione with ...
Compounds having the formula (I) or (II), are useful as p38 kinase inhibitors, wherein R is an optionally substituted alkyl, ... US20070135459A1 - Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors - Google Patents. Substituted 7-aza- ... Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors Related Parent Applications (1). Application Number. ... Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors Family Applications Before (1). Application Number. ...
17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones useful to treat baldness have formula (I), wherein R is selected from hydrogen ... 4-aza-5α-androstan-3-one (XI) which, is dehydrogenated as previously described to produce compound XIV, 17β-(acyl)-4-aza-5α- ... l-en-3-ones and related compounds, to treat baldness. The 17β-substituted benzoyl-4-aza- 5α-androst-l-en-3-one compounds of the ... 16-substituted-4-aza-androstane 5-alpha-reductase isozyme 1 inhibitors US5693809A (en) 1997-12-02. Substituted 4-aza-5α- ...
Aza Compounds / pharmacology * Bacteria, Aerobic / drug effects* * Bacteria, Aerobic / isolation & purification * Bacteria, ...
Aza-steroids. Part VII. 3-aza-A-homopregn-4a-ene and related compounds". Journal of the Chemical Society (Resumed): 3388. doi: ...
Preparation of α-aza-amino acid precursors and related compounds by novel methods of reductive one-pot alkylation and direct ... However, as these compounds are not available in nature, the peptide-degrading enzymes are unable to degrade them rapidly. ... One possibility is the replacement of native chiral amino acid by aza-amino acid where the chiral C-atom is replaced with N- ... It is also important to mention that aza-precursors are not described for all the natural amino acids. Due to these obstacles ...
Proceedings of the Seventh Conference on Zoo and Wildlife Nutrition, AZA Nutrition Advisory Group, Knoxville, TN. ... Hunt - EFFECT OF LENGTH OF COLD STORAGE ON SECONDARY PLANT COMPOUNDS IN BROWSE FOR CAPTIVE BLACK RHINOCEROS {DICEROS BICORNIS). ... The effect of length of cold storage on secondary plant compounds in browse for captive black rhinoceros (Diceros bicornis). In ... The effect of length of cold storage on secondary plant compounds in browse for captive black rhinoceros (Diceros bicornis). ...
Interaction of aza-aromatic compounds with porous silica beads and controlled porous glasses as studied by absorption and ... Interaction of aza-aromatic compounds with porous silica beads and controlled porous glasses as studied by absorption and ... Aza-aromaten , Silicate , Adsorptionskinetik , Absorptions- und Fluoreszenzspektroskopische. Aza-aromatics , Porous silicas , ... This is due to the difference in the effective diffusion coefficient of the three compounds into the glass sheet. Since the ...
Compound 1 and AZA are represented as sticks. Compounds 1 (grey) and AZA (yellow) are represented as sticks. Non-carbon atoms ... Stick representation compound 1 bound in the active site of hCA II. Atoms are coloured; zinc grey; sulfur, orange; oxygen, red ... Overall (a) and zoom-in (b) view of hCA II - sulfonamide 1 adduct, superposed onto acetazolamide (AZA) one (PDB accession code ... Schematic of hCA II - compound 1 interactions. Hydrophobic contacts are indicated by red hash marks and H-bonds by black dashed ...
Aza Compounds / adverse effects * Aza Compounds / therapeutic use* * Bacteria / drug effects * Bacteria / isolation & ...
Azelaic acid (AzA) is an organic compound with the formula HOOC(CH2)7COOH. This saturated dicarboxylic acid exists as a white ... In comparative review of effects of topical AzA, Salicylic acid, Nicotinamide, Sulfur, Zinc, and alpha-hydroxy acid AzA enjoyed ... Along with retinoids AzA is considered to be effective in improving acne-treatment results. The studies of latter though were ... AzA inhibits tyrosinase. Azelaic acid is industrially produced by the ozonolysis of oleic acid. The side product is nonanoic ...
0 (Aza Compounds); 0 (Drug Combinations); 0 (Insecticides); 0 (Macrolides); 0 (Spiro Compounds); 0 (ortho-Aminobenzoates); ... Compostos Aza/toxicidade. Cole pteros/crescimento & desenvolvimento. Combina o de Medicamentos. Ivermectina/an logos & ... The most potent compounds, M101, M122 and M133 exhibited remarkably enhanced anticancer potency against 6 kinds of cancer cell ... The most potent compounds, M101, M122 and M133 could be promising candidates for cancer therapy.. ...
PRIMA-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in ... Aza Compounds / pharmacology*. Bicyclo Compounds, Heterocyclic / pharmacology*. Breast Neoplasms / metabolism*. Cell Line, ... 0/2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one; 0/Antineoplastic Agents; 0/Aza Compounds; 0/Bicyclo Compounds, ... PRIMA-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in ...
Aza Compounds / therapeutic use*. Bacteria / isolation & purification*. Colony Count, Microbial. Conjunctiva / microbiology*. ... 0/Anti-Infective Agents, Local; 0/Aza Compounds; 0/Quinolines; 0/moxifloxacin; 25655-41-8/Povidone-Iodine ...
Hoffmann and Wynder reported aza-heterocyclic compounds, epoxides, paraffins, olefins, peroxides, and epoxides in urban ... Acetone condenses with reactive aromatic compounds (including PAHs) forming bridge compounds. Hydroxyacid amides react with ... but can react with many of the classes of compounds present in tobacco smoke to produce compounds that may be carcinogenic and ... Animal experiments are positive for the free metal and most compounds tested. Persons at High Risk for Cancer reports iron ...
... a mixture of an aqueous-alkaline solution of the organic dihydroxy compound and an aqueous catalyst solution being introduced ... High molecular weight linear polycarbonates are prepared by continuous condensation of organic dihydroxy compounds and phosgene ... Process for the preparation of polycarbonates catalyzed by cyclic aza compounds. US4529791 *. Aug 3, 1984. Jul 16, 1985. The ... Suitable dihydroxy compounds have the formula HO--R--OH in which R is for example a divalent aromatic radical consisting of one ...
Data Bank of HeII Photoelectron Spectra: Pt.II Aza-compounds (C,H,N), Electron Spectrosc. Relat. Phenom. 21, 93 (1980)CrossRef ... The question whether the early transition-metal compounds can be termed "Mott compounds", has not yet been settled, see S. ... Therefore a classification as a Mott compound or a charge-transfer compound (Fig.5.52) is not very meaningfull. Probably band- ... For an early review of PES in 3d transition-metal compounds see L.C Davis: J. Appl. Phys. 59, R25 (1986)CrossRefGoogle Scholar ...
Aza Compounds. Chemical TaxonomyProvided by Classyfire. Description. This compound belongs to the class of organic compounds ... Organic nitrogen compound / Organochloride / Organohalogen compound / Organonitrogen compound / Polyhalopyridine / Pyrrolidine ... Organic compounds. Super Class. Organoheterocyclic compounds. Class. Pyridines and derivatives. Sub Class. Halopyridines. ... Heteroaromatic compounds / Azetidines / Dialkylamines / Azacyclic compounds / Organochlorides / Hydrocarbon derivatives. ...
Aza-chromone compound showed Src kinase inhibition with an IC50 value of 15.8 µM. The compounds were subjected to molecular ... A CC of 0.835 was obtained when the SVR model was applied to the 17 synthesized compounds. It is envisaged that the work will ... A series of novel chromone/aza-chromone fused α-aminophosphonate derivatives were synthesized in good yields using silica ... All the synthesized compounds were tested for their c-Src kinase inhibitory activity. ...
History of allergic reactions attributed to compounds of similar chemical or biologic composition to 5-AZA and ATRA. ... Experimental: (5-AZA) + (ATRA) combination Combination of 5-Azacitidine (5-AZA) + all trans retinoic acid (ATRA) group after ... A Pilot Study of 5-AZA and ATRA for Prostate Cancer With PSA-only Recurrence After Local Treatment. The safety and scientific ... Other Name: 5-AZA. Drug: all trans retinoic acid 45 mg/m^2, will be taken orally on days 3-7 of each cycle, divided into two ...
2.2 Compounds Incorporating Single Atom Bridges: μ-Chloro, μ-Oxo and μ-Aza 72 ... 1 Archetypal Iridium(III) Compounds for Optoelectronic and Photonic Applications: Photophysical Properties and Synthetic ... 2.4 Compounds with Heterocyclic Bridges 82. 2.4.1 Bis-(N^N)-Coordinating Ligands and Related Systems Incorporating At Least One ... 1.9 Synthetic Methods Targeting C^N Cyclometalated Ir(III) Compounds 42. 1.10 Synthetic Methods for Cyclometalated Ir(III) ...
Polymeric resins derived from 1-oxa-3-aza tetraline group-containing compounds and cycloaliphatic epoxides. ...
1-aza-3,7-dioxabicyclo[3.3.0]octane compounds and their use as pro-fragrances. December, 2008. Huchel et al. ... Buckwheat compound and method of obtaining the same for treatment of hyperglycemia. February, 2006. Kwong et al. ...
For radical cyclization of 1-aza-spiro compounds, see: El Bialy et al. (2004. ); Dake (2006. ). For cephalotaxine synthesis, ... In the title compound, C21H22N2O, the planes of the two six-membered rings make a dihedral angle of 89.51 (7)°. The pyrrolidine ... organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\). CRYSTALLOGRAPHIC. COMMUNICATIONS. ... The title compound crystallizes in the monoclinic space group P21/c. The two phenyl rings are oriented to each other with a ...
Polyamine aza-cyclic compounds demonstrate anti-proliferative activity in vitro but fail to control tumour growth in vivo. ... Polyelectrolyte nanoparticles with high drug loading enhance the oral uptake of hydrophobic compounds. ...
The compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The ... labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a ... XCVII Synthesis of 5-Hydroxmethyl-6-Aza-2- Deoxyuridine and 5-Hydroxymethyl-6-Aza-2-Deoxycytidine," Collection Czechoslov. ... Nucleic Acid Labeling Compounds. The nucleic acid labeling compounds of the present invention are of the following structure; A ...
The compounds AZA, IFN and RTX were the most often used first-line therapies in our cohort. RTX was the most often used second- ... In recurrent treatment episodes with the same compound (observed for AZA, RTX, Mitox and IFN), we merged the two cycles if the ... The median dose of AZA was 150 mg per day (mean: 126 mg, range: 50-300 mg). Fifty per cent of AZA doses were 150 mg or above ... Treatment was changed from AZA to RTX in eight patients. This could have generated a bias in favour of a low ARR in the AZA ...
  • Other heterocyclic compounds can be envisioned similarly as derivatives of cyclopentane by substitution with other heteroatoms or of other carbocyclic compounds by substitution with nitrogen or other heteroatoms. (britannica.com)
  • In general, synthetic methods and physical and chemical properties of the saturated and the partly unsaturated heterocyclic compounds closely resemble those for their acyclic (noncyclic, or open-chain) analogs . (britannica.com)
  • Naming heterocyclic compounds is complicated because of the existence of many common names in addition to the internationally agreed-upon systematic nomenclature . (britannica.com)
  • for more information, see below Major classes of heterocyclic compounds . (britannica.com)
  • The synthesis of oxa- and aza-heterocyclic compounds. (espci.fr)
  • Compound 8a without the oxygen atoms in ring A appears to cause effects similarly to autophagy as induced by etoposide, a cancer drug analogue of our heterocyclic compounds. (scirp.org)
  • Heterocyclic compounds for producing dyes are classified in subclass C09B . (uspto.gov)
  • This paper deals with the synthesis and characterization of a macrocyclic ligand (L) and its new-fangled complex compounds of the general formula [M-L Cl 2 ] for M= Ru(III), and [M-L] for Pt(II) and Pd(II) where L is a macrocyclic ligand resulted from the condensation reaction of ethylene diamine and ethyl acetoacetate. (hindawi.com)
  • The present dissertation describes development of several new synthetic methods for preparation of aza-amino acid precursors and synthesis of previously unknown aza-methionine precursors. (ut.ee)
  • Traditionally, the most popular strategies towards the synthesis of dicoumarols start from salicylaldehyde and formal-dehyde 6 and involve the biosynthesis of dicoumarol using micro-organisms such as Penicillium jenseni, 7 or require the Knoevenagel condensation of 4-hydroxycoumarins with carbonyl compounds using several catalysts. (scielo.org.za)
  • The synthesis of 2-aza-norborane derivatives is presented. (diva-portal.org)
  • Topics covered include phosphines, applications of phosphorus (III) and (V) compounds as reagents in synthesis, the chemistry of phosphorus ylides, applications of the Wittig reaction in the synthesis of heterocyclic and carbocyclic compounds, preparation ofIminophosphoranes and their synthetic applications in the aza-Wittig reaction, phospho-transfer processes leading to [P-C] bond formation, low valent phosphorus compounds and phosphorus methods in oligonucleotide chemistry. (indigo.ca)
  • Organometallic compounds have also influenced material synthesis: Areas that have profited from the ready availability of volatile, stoichiometrically precisely defined molecular compounds of the metallic elements including synthesis of materials (metals, alloys, semi-conductors) by vapor deposition, of new molecular magnetic and electro optical materials (non-linear optics), of metal-organic frameworks as gas adsorbents, of metal-containing polymers, and of metallomeogens. (mdpi.com)
  • Thus organometallic compounds are currently finding wider applications in material synthesis as well. (mdpi.com)
  • This special issue invites contributions from areas where well-defined organometallic compounds contributed to the area of advanced material synthesis. (mdpi.com)
  • Pinacol type coupling of carbonyl compounds and their aza-analogues became an interesting task in the 1990s [1]. (thefreelibrary.com)
  • In addition to azaspiracid (AZA), four analogues, AZA 2 to AZA5, were isolated and their chemical structures were elucidated (see Figure 6.1). (fao.org)
  • 2001) determined the structure of two further analogues of azaspiracid found in mussels namely azaspiracid-4 (AZA-4) and azaspiracid-5 (AZA-5) and showed that these compounds were 3-hydroxy-22-demethylazaspiracid and 23-hydroxy-22-demethylazaspiracid, respectively (thus hydroxylated analogues of AZA-3). (fao.org)
  • The commonly used DNA demethylating agents include cytidine or deoxycytidine analogues, such as 5-azacytidine (5-azaC), 5-aza-2′-deoxycytidine (5-azadC), 1-β- d -arabinofuranosyl-5-azacytosine, and dihydro-5-azacytosine ( 7 ). (aacrjournals.org)
  • Our novel generated Aza-podophyllotoxin compounds (AZP 8a & AZP 9a) are analogues of podophyllotoxin and were previously screened for anti-cancer activity through the NCI 60 cell line screening panel showing activity on various cell types including colon cancer. (scirp.org)
  • Structural modifications leading to cyclic imino derivatives such as spinacine, aza-histidine and analogues with shortening or elongation of the native side chain (nor-histidine and homo-histidine, respectively) are also described. (mdpi.com)
  • The use of non-activated iminodieniphiles in stereoselective aza-Diels-Alder reaction has expanded the scope of the reaction and provided a convenient root for preparation of 2-aza-norboranes, analogues of which were developed into novel bicyclic 2-aza-norbornyl-oxazoline ligands for Ir-catalyzed asymmetric transfer hydrogenations. (diva-portal.org)
  • all of these compounds act as reaction-intermediate analogues of the proposed C14 carbonium ion intermediate. (eurekamag.com)
  • High molecular weight linear polycarbonates are prepared by continuous condensation of organic dihydroxy compounds and phosgene in two reaction zones, a mixture of an aqueous-alkaline solution of the organic dihydroxy compound and an aqueous catalyst solution being introduced at the rate of from 1 to. (google.com)
  • 4. A process as claimed in claim 1 wherein the organic dihydroxy compound used is 4,4'-dihydroxydiphenylmethane or 2,2-(4,4'-dihydroxydiphenyl)-propane. (google.com)
  • This compound belongs to the class of organic compounds known as polyhalopyridines. (drugbank.ca)
  • These are organic compounds containing a pyridine ring substituted at two or more positions by a halogen atom. (drugbank.ca)
  • Azelaic acid (AzA) is an organic compound with the formula HOOC(CH2)7COOH. (wikipedia.org)
  • Carboxylic acids are arguably the most common acids in organic chemistry and this structural motif is present in a myriad of compounds. (rsc.org)
  • The present invention relates to a compound represented by formula 1, an organic optoelectronic element comprising the same, and a display device comprising the organic optoelectronic element. (sumobrain.com)
  • EXECUTIVE SUMMARY Polycyclic Organic Matter (POM) is an aromatic hydrocarbon group that includes certain compounds which are proven carcinogens at ele- vated levels in laboratory animals. (epa.gov)
  • The molecules of organic chemical compounds are built up from a framework or backbone of carbon atoms to which are attached hydrogen (H), oxygen, or other heteroatoms. (britannica.com)
  • The simplest organic compounds are the hydrocarbons , compounds of carbon and hydrogen only. (britannica.com)
  • For example, we recently described the superacid‐catalyzed aza‐Nazarov reaction, eq 1 (Organic Letters 2007, 9, 3085). (niu.edu)
  • With unusual charge migration and benzene elimination steps, we were able to prepare a series of functionalized aza‐polycyclic aromatic compounds, such as the benzo[f]isoquinoline, eq 2 (Organic Letters 2006, 8, 1233 and J. Org. (niu.edu)
  • This index lists the names of all compounds found in the 'IR - Industrial Chemicals, Basic Organic Compounds - Wiley' spectral database. (knowitall.com)
  • We offer over 100 Chiral Phosphoric Acids for R&D including: BINOL-, SPINOL-, and TADDOL derived CPA that can be applied as an effective tool for numerous en antioselective organic transformations. (strem.com)
  • Organic compounds containing at least one heterocyclic ring, and with no ring comprising a steroid, saccharide or peptide moiety. (uspto.gov)
  • The only exception to this requirement is that the compounds may contain metal atoms, but only as the cations of heterocyclic organic acid salts, alcoholates, phenolates or mercaptides, or as chelating atoms, e.g. in porphyrins. (uspto.gov)
  • The present invention provides compounds having the general structural formula (I) (I) and pharmaceutically acceptable derivatives thereof, as described. (patents.com)
  • A series of novel chromone/aza-chromone fused α-aminophosphonate derivatives were synthesized in good yields using silica chloride as the catalyst. (niscair.res.in)
  • The present disclosure refers to 10-(di(phenyl)methyl)-4- hydroxy-8,9,9a,10-tetrahydro-7H-pyrrolo[1';2':4,5]pyrazino[1 ,2- b]pyridazine-3,5-dione derivatives and related compounds of Formula (A) as inhibitors of the orthomyxovirus replic. (sumobrain.com)
  • The present invention relates to deuterated derivatives of 9-(2,5-difluorophenethyl)-4- ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one having pharmacological activity, to processes of preparation of such compounds, to pharmaceutic. (sumobrain.com)
  • Drug stimulation of topoisomerase II-mediated DNA cleavage is remarkably attenuated in the aza-bioisosteric derivatives, suggesting that other non-enzyme-mediated cytotoxic mechanism(s), possibly connected with free radical production, are responsible for efficient cell killing. (aspetjournals.org)
  • The present invention relates to certain quinazoline compounds useful as p38 protein kinase inhibitors. (google.com)
  • The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). (patents.com)
  • The novel compounds of the present invention are those of structural formula I: ##STR1## or a pharmaceutically acceptable salt, ester, or stereoisomer thereof, which are inhibitors of 5.alpha. (patentgenius.com)
  • Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical composition thereof, which are useful as dual. (patents.com)
  • The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. (sumobrain.com)
  • These novel compounds offer an alternative when the disease progresses and patients fail to respond to standard dopaminergic treatments or side-effects increased. (eurekaselect.com)
  • A compound represented by general formula (1): (in formula (1), A shows a C6-30 divalent aromatic group for forming an aromatic ring, or the like, and the plurality of R1 each independently show a hydrogen atom or the like), tetracarb. (sumobrain.com)
  • Aromatic compounds, though having double bonds, are extremely stable and do not readily undergo the addition reactions characteristic of other unsaturated compounds. (britannica.com)
  • The "HiersoPHOS" family of ligands are ferrocenyl polyphosphine ligands which may be used in Palladium promoted catalytic transformations such as the functionalization of hetero-aromatic compounds and various carbon-carbon and carbon-nitrogen bond formation reactions (Suzuki-Miyaura coupling, Heck coupling, Buchwald-Hartwig cross-coupling as well as Sonogashira reactions). (strem.com)
  • Disclosed are methods and compositions for the preparation of steroid 5α-reductases by recombinant means, as well as for the use of these enzymes in screening assays for the identification of compounds which have the ability to inhibit or otherwise alter the enzymatic function of these enzymes. (google.co.uk)
  • Thepresent invention relates to anti-bacterially active compounds, to their preparation and to compositions containing them. (patentgenius.com)
  • Compounds, compositions and methods are provided for the inhibition of GBP1. (sumobrain.com)
  • Provided herein are oxa- and aza-tricyclic 4-pyridone-3-carboxylic acid compounds, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for inhibiting HBsAg secretion and HBV DNA production, and fo. (sumobrain.com)
  • Only one compound, the derivatized 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide with the coumarinyl tail, showed effective inhibition of the transmembrane isoforms, with KIs of 5.9-14.2 nM, although it was less effective as hCA I and II inhibitor (KIs of 36-120 nM). (nih.gov)
  • In this study we investigated the efficacy of low-dose 5-aza-2′-deoxycitydine (DAC), a methylation inhibitor, with interleukin (IL) 12, one of the most potent cytokines with antitumor activity. (aacrjournals.org)
  • The subject inhibitor compounds can act by inhibiting GBP1 alone and/or GBP1 : pro-survival kinase (e.g. serine/threonine-protein kinase pim-1 (PIM1 )) interact. (sumobrain.com)
  • Compounds incorporating 7-methoxy-coumarin-4-yl-acetamide-tails and benzenesulfonamide and benzene-1,3-disulfonamide scaffolds showed medium potency inhibition of hCA I (KIs of 73-131 nM), effective hCA II inhibition (KIs of 9.1-36 nM) and less effective hCA IX and XII inhibition (KIs of 55-128 nM). (nih.gov)
  • Thus, sulfonamides incorporating coumarin rings have a distinct inhibition mechanism compared to the coumarins, and may lead to compounds with interesting inhibition profiles against various alpha-CAs found in mammals or parasites, such as Plasmodium falciparum. (nih.gov)
  • Aza-chromone compound showed Src kinase inhibition with an IC 50 value of 15.8 µM. (niscair.res.in)
  • In vitro, when vitamin C is added at physiological levels to low doses of the DNMTi 5-aza-2′-deoxycytidine (5-aza-CdR), there is a synergistic inhibition of cancer-cell proliferation and increased apoptosis. (pnas.org)
  • Against hCA II, all the compounds showed excellent to moderate inhibition with Ki values of compounds 5a, 5d, 5f, 6a-6f, 8d and 8f lower than 12nM (Ki of AZA). (unboundmedicine.com)
  • Against hCA IX, all the compounds showed moderate inhibition with the exception of 6e which showed nearly 9 fold a better profile compared to AZA, whereas against hCA XII, four compounds 6e, 7a, 7b and 7d showed Ki in the same order as that of AZA. (unboundmedicine.com)
  • One possibility is the replacement of native chiral amino acid by aza-amino acid where the chiral C-atom is replaced with N-atom. (ut.ee)
  • Chiral carboxylic acids exist widely in nature in the form of amino acids and compounds such as tartaric acid, malic acid, cholic acid, biotin, etc. (rsc.org)
  • Moreover, these compounds are known to be highly biologically active and of therapeutic importance [3, 4]. (thefreelibrary.com)
  • As a result, RNA viruses have been hypothesized to be susceptible to compounds that would elevate the viral mutation rate, a therapeutic strategy referred to as lethal mutagenesis ( 5 ). (asm.org)
  • Biocidal, pest attractant, or plant growth regulatory activity of chemical compounds or preparations is further classified in subclass A01P (this subclass does only exist in IPC).Therapeutic activity of chemical compounds is further classified in subclass A61P . (uspto.gov)
  • A number of SAR inducers have been identified, including the chemical signals salicylic acid (SA) ( 2 ), azelaic acid (C 9 dicarboxylic acid, AzA) ( 3 , 4 ), glycerol-3-phosphate (G3P) ( 4 , 5 ), nitric oxide (NO), reactive oxygen species (ROS) ( 6 - 8 ), and galactolipids ( 9 ). (sciencemag.org)
  • We believed that azelaic acid (AZA) could modulate melanomas' resistance to antineoplastics. (eurekamag.com)
  • The present invention provides a compound with a structure represented by general formula I or a pharmaceutically acceptable salt thereof, a preparation method for the compound or the salt, and a use of the compound or the pharmaceutical. (sumobrain.com)
  • Accordingly the present invention provides compounds of the formula (II): ##STR2## and salts and esters thereof wherein R is a hydrogen atom or an acyl group. (patentgenius.com)
  • Most suitably R is an hydrogen atom so that particularly suitable compounds of this invention include those of the formula (III): ##STR4## and salts and esters thereof. (patentgenius.com)
  • Most suitably esters of the compounds of the formulae (II) and (III) are those which are readily convertable by chemical means to the compound of formula (II) or (III) per se or a salt thereof or those which are converted in-vivo to the compoundof the formula (II) and (III) per se or a salt thereof. (patentgenius.com)
  • 9. The method of claim 7 , wherein the compound is selected from the group consisting of tamoxifen, cenchroman, clomiphene, droloxifene, raloxifene and pharmaceutically acceptable salts thereof. (google.es)
  • When added to non-aqueous battery electrolytes, the new family of aza-ether based compounds acts as neutral receptors to complex the anion moiety of the electrolyte salt thereby increasing the conductivity and the transference number of LI.sup. (osti.gov)
  • A range of these compounds have also been utilized in anion binding catalysis, 28-34 and many other innovative applications have been established. (rsc.org)
  • Ion-selective electrodes for antibiotics from the penicillin series, with membranes based on three different classes of ionophores (anion exchangers, aza compounds, and metal phthalocyanines), were proposed. (ebscohost.com)
  • Substitution of one or more of the ring carbon atoms in the molecules of a carbocyclic compound with a heteroatom gives a heterocyclic compound. (britannica.com)
  • When one of the carbon atoms of cyclopentane is replaced with an atom of nitrogen, the compound pyrrolidine, a chemical relative of pyrrole , is produced. (britannica.com)
  • Nonaromatic unsaturated compounds are highly reactive-that is, they readily undergo additions of atoms or groups of atoms to the carbon atoms of their double bonds, giving each carbon four substituents. (britannica.com)
  • Compound 9a with the oxygen atoms in expanded ring A presented induction of cell death following activation of a classical apoptosis pathway. (scirp.org)
  • The conversion of E1 into E2 is reduced by nearly 90 % by 17β-(Nalkylformamido)- 4-methyl-4-aza-5α-androstan-3-one compounds bearing a side chain containing 7 to 10 carbon atoms when tested at 0.3 μM. (eurekaselect.com)
  • The process comprises oxidizing a feed stream comprising at least one oxidizable compound to generate a crude carboxylic acid slurry co. (sumobrain.com)
  • Although primarily targeting a chemistry audience, the wide applicability of these compounds transcends traditional disciplines, making this text also of use to physicists, materials scientists or biologists who have interests in these areas. (wiley.com)
  • Since the 2‑oxyindole ring system is present in a large number of biologically active compounds, this chemistry represents a useful new synthetic methodology. (niu.edu)
  • In particular, the present invention relates to 2-amino-6-phenyloxy substituted 7-azaquinazoline compounds, pharmaceutical preparations comprising the same, and methods for using them. (google.com)
  • This invention relates to compounds (Formula (1)) that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1. (patents.com)
  • Overall (a) and zoom-in (b) view of hCA II - sulfonamide 1 adduct , superposed onto acetazolamide ( AZA ) one (PDB accession code 3hs4). (nih.gov)
  • Against the human isozyme hCA I, compounds 6a-6f showed medium-weak inhibitory potential with Ki values in the range of 157-690nM with 6a showing better potential than the standard drug acetazolamide (AZA). (unboundmedicine.com)
  • This study confirms the potential of the polycyclic structures as lead compounds in the search for molecules that prevent neuronal death due to apoptosis. (nwu.ac.za)
  • Their dualistic effects, as well as the possibility of sigma receptor activity provide new avenues for investigation in the search for biological lead compounds amongst the polycyclic compounds. (nwu.ac.za)
  • A new iron(III) halide-promoted aza-Prins cyclization between γ,δ-unsaturated tosylamines and aldehydes provides six-membered azacycles in good to excellent yields. (csic.es)
  • In addition, the alkyne aza-Prins cyclization between homopropargyl tosylamine and aldehydes gives 2-alkyl-4-halo-1-tosyl-1,2,5,6-tetrahydropyridines as the only cyclic products. (csic.es)
  • The use of these compounds in preparation of Ir catalysts for asymmetric hydrogenations is described. (diva-portal.org)
  • Dear Colleagues, Organometallic compounds, molecules that contain at least one metal-carbon or metal-hydrogen bond, have had an enormous impact on the development of homogeneous catalysts. (mdpi.com)
  • The usefulness of organometallic compounds also expands beyond homogeneous catalysts to molecular-defined supported catalysts which are expected to combine the precise mechanistic feature of homogeneous systems with the robustness of heterogeneous catalysts. (mdpi.com)
  • Researchers found that bacteria essential to ripening cheese can sense and respond to compounds produced by fungi in the rind and released into the air, enhancing the growth of some species of bacteria over others. (brightsurf.com)
  • To assess the pharmacodynamic effects of 5-AZA and entinostat on deoxyribonucleic acid (DNA) methylation, histone acetylation, and gene re-expression in patients with recurrent NSCLC through analysis of blood, sputum and tissue biopsies. (clinicaltrials.gov)
  • Here, we report that a quinoline-based compound, designated SGI-1027, inhibits the activity of DNMT1, DNMT3A, and DNMT3B as well M. Sss I with comparable IC 50 (6-13 μmol/L) by competing with S -adenosylmethionine in the methylation reaction. (aacrjournals.org)
  • New heteroaromatic compounds. (nist.gov)
  • The fungal kingdom has been widely studied as a source of bioactive compounds of interest to the pharmaceutical and food industry. (springer.com)
  • 7. The method of claim 1 , wherein the pharmaceutical formulation further includes a compound selected from the group consisting of steroid agonists, partial agonists and antagonists. (google.es)
  • The present invention provides: a novel compound which is characterized by being capable of increasing the number of heart beats or a blood pressure mildly to. (patents.com)
  • In a specific aspect, the phenol resin composition of the present invention is characterized in that it contains boehmite having an aspect ratio within a range from 1 to 100 and also contains an alumina-based compound as a filler, an amount of the boehmite being from 1 to 150 parts by weight based on 100 parts by weight of the phenol resin. (google.com.au)
  • In comparative review of effects of topical AzA, Salicylic acid, Nicotinamide, Sulfur, Zinc, and alpha-hydroxy acid AzA enjoyed more high-quality evidence of effectiveness than the rest. (wikipedia.org)
  • More recent review claimed 20% AzA being more potent than 4% hydroquinon after period of application for three months without latter's adverse effects and even more effective if applied along with tretinoin for the same period of time. (wikipedia.org)
  • Preparation of such compounds, including purification, separation, stabilisation or use of additives, unless a separate place is provided elsewhere in the classification scheme. (uspto.gov)
  • The publication disclosed the claimed compound structure while the patents taught methods of making compounds of that general class. (uspto.gov)
  • Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are de. (sumobrain.com)
  • Preparations for medical, dental, or toilet purposes or methods of using compounds for the same purposes are classified in subclass A61K . (uspto.gov)
  • N.B.: when the compound per se is novel, the medicinal preparation and/or methods of use are not classified in A61K 31/00 in CPC). (uspto.gov)
  • Methods: To evaluate DNMT3b expression, DNMT3B mRNA levels in HCT116 CRC cell line were quantified by real-time reverse-transcriptase Polymerase Chain Reaction [PCR] assay after 24 hr of incubation time with CPUK02 and 5-AZA. (bvsalud.org)
  • These results were interpreted as indicating that the compounds were antiandrogenic by virtue of their ability to inhibit testosterone-5α-reductase. (google.com)
  • A number of 4-aza steroid compounds are known. (google.com)
  • 8. The method of claim 7 , wherein the compound is selected from the group consisting of steroid agonists and partial agonists. (google.es)
  • In addition to these characteristics that might define them as NMDAR antagonists, the triquinylamines also share structural similarities to the pentacycloundecane cage compounds. (nwu.ac.za)
  • By analogy with pectenotoxins and yessotoxins, that undergo structural modification by hydroxylation in mussels, it may be assumed that AZA-4 and AZA-5 are oxidized metabolites of AZA-3. (fao.org)
  • La combinación más efectiva fue el empleo de partículas de E. grandis, combinadas indistintamente con los cementos CPC40 o ARI50, adicionados con 3% de cloruro de calcio Resumen en inglés The most part of residues generated during wood mechanic processing remains unexplored for construction material non-structural compounds production. (worldwidescience.org)
  • Structural data showed that all target compounds exist as the enamine tautomer. (hindawi.com)
  • A number of structural modifications of parent compounds have led to enhanced agonism but also partial agonism or even antagonism of one or more dopamine receptors. (eurekaselect.com)
  • Heterocycles incorporating elements other than C, H, halogen, N, O, S, Se or Te are classified in subclass C07F , but only if the metal-containing compound has a metal carbon bond or if the metal is attached to at least two different ligands. (uspto.gov)
  • All the synthesized compounds were tested for their c-Src kinase inhibitory activity. (niscair.res.in)
  • Reactivation of silenced tumor suppressor genes by 5-azacytidine (Vidaza) and its congener 5-aza-2′-deoxycytidine (decitabine) has provided an alternate approach to cancer therapy. (aacrjournals.org)
  • deoxycytidine (AZA) to promote DNA demethylation. (omicsonline.org)
  • While experimental results in cell culture have been promising, the clinical translation of lethal mutagenesis has been a slow process due largely to a lack of strong lead compounds. (asm.org)
  • The chemical compounds identified were two naphthoquinones, fusarubin and dihydrofusarubin, and an anthraquinone, a bostrycoidin, being fusarubin the majority compound. (springer.com)
  • 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones useful to treat baldness have formula (I), wherein R is selected from hydrogen, methyl and ethyl and R2 is phenyl substituted with one or more of: -OH, -OC¿1? (google.com)
  • The compounds according to formula may be used in fine and functional perfumery, air care and household products, laundry products, body care and cosmetics. (cosmeticsandtoiletries.com)
  • The compounds of formula I are useful in the oral, systemic, parenteral or topical treatment of hyperandrogenic conditions. (patentgenius.com)
  • No: 827926 discloses inter alia the compound of the formula (I): ##STR1## and its salts and esters. (patentgenius.com)
  • We have now discovered that it is possible to reduce the double bond inthe compound of formula (I) and surprisingly still retain antibacterial activity. (patentgenius.com)
  • The stereochemistry at the 3 and 7 positions of the compound of the formula (II) is the same as found in naturally occurring penicillins and cephalosporins. (patentgenius.com)
  • Most suitably salts of the compounds of the formula (II) and (III) are pharmaceutically acceptable salts such as the sodium, potassium, calcium, magnesium, aluminium, ammonium and conventional substituted ammonium salts. (patentgenius.com)
  • More particularly provided is a compound shown in formula (I), an isomer, a hydrate, a solvate, a pharmaceutically acceptable. (sumobrain.com)
  • For example, provided herein are compounds of Formula I, or a stere. (sumobrain.com)
  • Due to these obstacles there is a need for a new, more convenient synthetic routes, which will help to complete the list of aza-precursors for replacement of as many as possible amino acids. (ut.ee)
  • Estos resultados permiten concluir que las 1,4- dihidropiridinas I y II poseen acciones antagonistas del calcio vasoselectivas marcadas y este mecanismo está dado por el bloqueo de la corriente de calcio tipo L de manera dependiente del potencial Resumen en inglés The calcium antagonist properties of 2 new 1,4 synthetic dihydropyridines (I and II) were studied. (worldwidescience.org)
  • Dr I O'Neil and Dr J.M. Southern: Preparation and reactions of Iminophosphoranes and their synthetic applications in the aza-Wittig reaction7. (indigo.ca)
  • The marine dinophycean genus Azadinium has been identified as the primary source of azaspiracids (AZA), a group of lipophilic phycotoxins known to accumulate in shellfish. (awi.de)
  • Our results present contrasting apoptotic activity between the experimental compounds. (scirp.org)
  • 2-Aza-norbornyl-oxazolines were also developed into novel N,P-ligands. (diva-portal.org)
  • 5-aza-C acts similarly to its DNA-based counterpart 5-aza-deoxyC, but is not nearly as effective. (eurekalert.org)
  • Similarly, compounds containing saccharide radicals are classified in subclass C07H , and heterocyclic steroids are classified in subclass C07J . (uspto.gov)
  • c) photoactivating said compound in said first blood bag so as to create a treated platelet preparation. (google.ca)
  • An additional compound, the lactol derivative of the triquinanes, was synthesised by reducing the triquinane dione with sodiumborohydride. (nwu.ac.za)
  • Progesterone 3-oxime (P4-3-O), also known as 3-(hydroxyimino)pregn-4-en-3-one, is a progesterone derivative which was never marketed. (wikipedia.org)
  • The compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). (google.com.au)