Identification of the canarypox virus thymidine kinase gene and insertion of foreign genes. (1/54)

We mapped the canarypox virus (CaPV) thymidine kinase (TK) gene within a 5.8-kbp XbaI fragment of the genome by Southern blotting using the fowlpox virus (FPV) TK gene as a probe. Nucleotide sequence analysis of the fragment revealed seven open reading frames (ORFs) showing gene organization similar to that of FPV. The TK gene contained in this region had an ORF of 179 amino acids encoding a polypeptide with a putative molecular mass of 20.0 kDa. An A/T-rich region and a transcription termination signal, TTTTTAT, were found upstream and at the end of the ORF, which is consistent with poxvirus early gene regulation. The consensus sequence of the late promoter TAAAT also overlapped with the initiation codon of the ORF. The amino acid sequence similarity between the TK genes of CaPV and FPV, avipoxviruses, was 64.2%, which was lower than the similarities between vaccinia and variola orthopoxviruses (97.2%) and between Shope fibroma and myxoma leporipoxviruses (82.6%). However, the monophyly of avian clades of CaPV and FPV was supported by phylogenetic analysis. We then inserted the genes encoding lacZ, luciferase (luci), and envelope of human T-lymphotropic virus type 1 (HTLV-1 env) into the TK gene of CaPV to evaluate its suitability as an expression vector. The recombinant viruses obtained were unstable, although the foreign genes were expressed efficiently in the mammalian cells infected with the viruses.  (+info)

Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors. (2/54)

Advances in understanding the role of dendritic cells (DCs) as the major antigen (Ag)-presenting cell type of the immune system combined with the recent development of methods for the ex vivo expansion of human DCs have opened the possibility for the transfer of tumor Ags to DCs with a view toward tumor immunotherapy. In this study, we examined the feasibility of Ag transfer to cultured human DCs using the host range-restricted avipoxvirus, fowlpoxvirus (FWPV). FWPV was found to infect and express a lacZ marker gene in a number of mammalian cell lines of fibroblastic, epithelial, and hemopoietic lineage origins. LacZ recombinant FWPV (rFWPV) was found subsequently to infect human DCs that had been cultured ex vivo from peripheral blood monocytes. Using rFWPV containing lacZ under the control of a vaccinia virus (VV) early/late promoter (p7.5K) and a 10 plaque-forming units per cell multiplicity of infection, >80% of cells expressed the lacZ marker gene. Quantitative analysis showed that the level of expression continued to rise for 5 days postinfection, at which point the experiments were terminated. Replication-competent recombinant VV (rVV) was also shown to be capable of transferring the marker gene to primary DC cultures. However, neither rFWPV nor rVV were able to express transgenes under the control of late viral promoters, indicating that both rFWPV and rVV infections are arrested at an early stage in human DCs. Infection of CD83 + DCs by rFWPV was confirmed by double-staining cytochemistry. We conclude that host range-restricted FWPV can be used efficiently to transfer Ag genes to human DCs ex vivo and may have a role in the development of tumor immunotherapy protocols.  (+info)

A canarypox vaccine expressing multiple human immunodeficiency virus type 1 genes given alone or with rgp120 elicits broad and durable CD8+ cytotoxic T lymphocyte responses in seronegative volunteers. (3/54)

Induction of CD8+ cytotoxic T cells is considered one of the important correlates for the protective efficacy of candidate human immunodeficiency virus type 1 (HIV-1) vaccines. To induce CD8+ cytotoxic T lymphocytes (CTLs) along with neutralizing antibody and CD4+ T cell help, a live canarypox virus construct expressing gp120, transmembrane gp41, the gag and protease genes, and sequences containing CTL epitopes in nef and pol was given simultaneously with, or followed by, rgp120 SF2. CD8+ CTLs were detected in 61% of volunteers at some time during the trial. Three to 6 months after the last immunization, the gene-specific responses were gag, 26/81; env, 17/77; nef, 12/77; and pol, 3/16. Simultaneous immunization with the canarypox vector and the subunit, beginning with the initial immunization, resulted in earlier antibody responses. In summary, a strategy of immunization with a canarypox vector expressing multiple genes of HIV-1 given with gp120 results in durable CD8+ CTL responses to a broad range of epitopes.  (+info)

A canarypox vector expressing cytomegalovirus (CMV) glycoprotein B primes for antibody responses to a live attenuated CMV vaccine (Towne). (4/54)

To develop a vaccine against cytomegalovirus (CMV), a canarypox virus (ALVAC) expressing CMV glycoprotein (gB) was evaluated alone or in combination with a live, attenuated CMV vaccine (Towne). Three doses of 106.5 TCID50 of ALVAC-CMV(gB) induced very low neutralizing or ELISA antibodies in most seronegative adults. However, to determine whether ALVAC-CMV(gB) could prime for antibody responses, 20 seronegative adults randomly received either 106.8 TCID50 of ALVAC-CMV(gB) or 106.8 TCID50 of ALVAC-RG, expressing the rabies glycoprotein, administered at 0 and 1 month, with all subjects receiving a dose of 103.5 pfu of the Towne vaccine at 90 days. For subjects primed with ALVAC-CMV(gB), neutralizing titers and ELISA antibodies to CMV(gB) developed sooner, were much higher, and persisted longer than for subjects primed with ALVAC-RG. All vaccines were well tolerated. These results demonstrate that ALVAC-CMV(gB) primes the immune system and suggest a combined-vaccine strategy to induce potentially protective levels of neutralizing antibodies.  (+info)

Identification of five MAGE-A1 epitopes recognized by cytolytic T lymphocytes obtained by in vitro stimulation with dendritic cells transduced with MAGE-A1. (5/54)

MAGE genes are expressed by many human tumors of different histological types but not by normal cells, except for male germline cells. The Ags encoded by MAGE genes and recognized by T cells are therefore strictly tumor-specific. Clinical trials involving therapeutic vaccination of cancer patients with MAGE antigenic peptides or proteins are in progress. To increase the range of patients eligible for therapy with peptides, it is important to identify additional MAGE epitopes recognized by CTL. Candidate peptides known to bind to a given HLA have been used to stimulate T lymphocytes in vitro. In some instances, CTL clones directed against these synthetic peptides have been obtained, but these clones often failed to recognize tumor cells expressing the relevant gene. Therefore, we designed a method to identify CTL epitopes that selects naturally processed peptides. Monocyte-derived dendritic cells infected with a recombinant canarypoxvirus (ALVAC) containing the entire MAGE-A1 gene were used to stimulate CD8+ T lymphocytes from the blood of individuals without cancer. Responder cell microcultures that specifically lysed autologous cells expressing MAGE-A1 were cloned using autologous stimulator cells either transduced with a retrovirus coding for MAGE-A1 or infected with recombinant Yersinia-MAGE-A1 bacteria. The CTL clones were tested for their ability to lyse autologous cells loaded with each of a set of overlapping MAGE-A1 peptides. This strategy led to the identification of five new MAGE-A1 epitopes recognized by CTL clones on HLA-A3, -A28, -B53, -Cw2, and -Cw3 molecules. All of these CTL clones recognized target cells expressing gene MAGE-A1.  (+info)

Phase I study in cancer patients of a replication-defective avipox recombinant vaccine that expresses human carcinoembryonic antigen. (6/54)

PURPOSE: A phase I clinical trial in patients with advanced carcinoma was conducted, using a replication-defective avipox vaccine containing the gene for the human carcinoembryonic antigen (CEA). The canarypox vector, designated ALVAC, has the ability to infect human cells but cannot replicate. PATIENTS AND METHODS: The recombinant vaccine, designated ALVAC-CEA, was administered intramuscularly three times at 28-day intervals. Each cohort of six patients received three doses of either 2.5 x 10(5), 2.5 x 10(6), or 2.5 x 10(7) plaque-forming units of vaccine. RESULTS: The vaccine was well tolerated at all dose levels and no significant toxicity was attributed to the treatment. No objective antitumor response was observed during the trial in patients with measurable disease. Studies were conducted to assess whether ALVAC-CEA had the ability to induce cytolytic T-lymphocyte (CTL) responses in patients with advanced cancer. Peripheral blood mononuclear cells (PBMCs) from patients with the MHC class I A2 allele were obtained before vaccine administration and 1 month after the third vaccination. Peripheral blood mononuclear cells were incubated with the CEA immunodominant CTL epitope carcinoembryonic antigen peptide-1 and interleukin 2 and quantitated using CTL precursor frequency analysis. In seven of nine patients evaluated, statistically significant increases in CTL precursors specific for CEA were observed in PBMCs after vaccination, compared with before vaccination. CONCLUSION: These studies constitute the first phase I trial of an avipox recombinant in cancer patients. The recombinant vaccine ALVAC-CEA seems to be safe and has been demonstrated to elicit CEA-specific CTL responses. These studies thus form the basis for the further clinical exploration of the ALVAC-CEA recombinant vaccine in phase I/II studies in protocols designed to enhance the generation of human T-cell responses to CEA.  (+info)

Efficient human immunodeficiency virus ( HIV)-1 Gag-Env pseudovirion formation elicited from mammalian cells by a canarypox HIV vaccine candidate. (7/54)

Canarypox viruses undergo abortive replication in mammalian cells. Despite this restriction on replication in mammalian cells, significant immune responses have been shown in animals and in humans receiving recombinant canarypox vaccine vectors expressing heterologous immunogens. A recombinant canarypox vaccine candidate (vCP205), which expresses human immunodeficiency virus (HIV)-1 Gag, Env, and protease proteins, is presently under investigation in phase I and phase II human trials in the United States and elsewhere. In this study, the ability of vCP205 to elicit HIV Gag-Env pseudovirion formation in avian and mammalian cells was investigated. Gag-Env pseudovirions were produced from both avian and mammalian cell lines infected by this vaccine vector. A subset of mammalian cells was identified in which pseudovirion production and release was very efficient, surpassing the production from infected avian cells. The production of Gag-Env pseudovirions by canarypox HIV vaccine vectors may have important implications for future HIV vaccine design.  (+info)

Viral vector delivery in solid-state vehicles: gene expression in a murine prostate cancer model. (8/54)

BACKGROUND: Although there are increasingly more clinical trials involving gene therapy, efficient gene transfer remains a major hurdle to success. To enhance the efficiency of delivery of viral vectors in gene therapy protocols, we evaluated the effect of various matrices to act as a vehicle for recombinant virus during intratumoral injection. METHODS: The ability of several vehicles (catgut spacer, polyglycolic acid, chromic catgut, and gelatin sponge matrix) to deliver the canarypox virus ALVAC to the cells of the murine prostate cancer cell line RM-1 was studied in vitro and in vivo. ALVAC recombinants encoding the murine cytokines interleukin 2 (IL-2), interleukin 12 (IL-12), and tumor necrosis factor-alpha (TNF-alpha) were used to assess enhancement of antitumor activity after intratumoral inoculation. Confirmatory experiments were conducted by use of another mouse prostate cancer cell line, RM-11, and a mouse bladder cancer cell line, MB-49. All statistical tests were two-sided. RESULTS: The gelatin sponge matrix proved to be the most effective solid-state vehicle for delivering viral vectors to cells in culture. In addition, this matrix statistically significantly enhanced expression of ALVAC-delivered reporter genes in tumor models when compared with fluid-phase delivery of virus (P =.037 for the RM-1 model and P =.03 for the MB-49 model). Statistically significant growth inhibition of established tumors was observed when a combination of the three recombinant ALVAC viruses expressing IL-2, IL-12, and TNF-alpha was delivered with the matrix in comparison with 1) fluid-phase intratumoral injection of the ALVAC recombinants, 2) no treatment, or 3) treatment with parental ALVAC (all P<.05). CONCLUSIONS: Viral vector delivery in a solid-state vehicle resulted in improved recombinant gene expression in vivo and translated to greater inhibition of tumor growth in an immunotherapy protocol for heterotopic tumor nodules. The efficient delivery of reporter genes described herein may prove useful in many solid tumor gene therapy protocols.  (+info)

*Virus-Taxonomie

Genus Avipoxvirus. *Genus Capripoxvirus. *Genus Centapoxvirus. *Genus Cervidpoxvirus. *Genus Crocodylidpoxvirus. *Genus ...

*Chordopoxvirinae

The genus Avipoxvirus diverged from the ancestor 249 ± 69 thousand years ago. The ancestor of the genus Orthopoxvirus was next ... The species in the genus Avipoxvirus infect birds; those in the genera Caiman poxvirus and Crocodylipoxvirus both infect ... Group: dsDNA Order: Unassigned Family: Poxviridae Sub-Family: Chordopoxvirinae Genus: Avipoxvirus Canarypox virus Fowlpox virus ...

*Parapoxvirus of red deer in New Zealand

Other Chordopoxvirinae genuses include; Orthopoxvirus, Avipoxvirus, Capripoxvirus, Leporipoxvirus, Suipoxvirus, ...

*Turkeypox virus

Avipoxvirus infections have been reported in over 232 bird species in 23 orders of birds, but most of our knowledge comes from ... Turkeypox virus is a virus of the family Poxviridae and the genus Avipoxvirus that causes turkeypox. It is one of the most ... Transmission of avipoxvirus occurs through a mosquito vector. Timoney, John Francis (1988), Hagan and Bruner's Microbiology and ... Turkeypox virus is a member of the Poxviridae family and is in the Avipoxvirus genus. There are currently 9 other species ...

*Canarypox

... viruses, as with other bird pox viruses, are in the genera of Avipoxvirus. Nine other species are also in the genus ... Canarypox virus (CNPV) is an Avipoxvirus and etiologic agent of canarypox, a disease of wild and captive birds that can cause ... "110 years of Avipoxvirus in the Galapagos Islands". PLoS ONE. 6 (1): e15989. doi:10.1371/journal.pone.0015989. PMC 3020966 . ... Avipoxvirus. These include: Fowlpox virus, Juncopox virus, Mynahpox virus, Psittacinepox virus, Sparrowpox virus, Starlingpox ...

*Patricia G. Parker

"110 Years of Avipoxvirus in the Galapagos Islands". PLoS ONE. 6 (1): e15989. doi:10.1371/journal.pone.0015989. PMC 3020966 . ...

*Fowlpox

... is the worldwide disease of poultry caused by viruses of the family Poxviridae and the genus Avipoxvirus. The viruses ... Species Profile- Fowlpox (Avipoxvirus), National Invasive Species Information Center, United States National Agricultural ...

*Avian malaria

Since then, avian malaria and avipoxvirus together have devastated the native bird population, resulting in many extinctions. ...

*Hawaiian crow

... can be attributed to the birds club that brought nonnative species to replace birds that fell victim to the Avipoxvirus. At ...

*Taxonomic list of viruses

Avipoxvirus Canarypox virus Fowlpox virus Juncopox virus Mynahpox virus Pigeonpox virus Psittacinepox virus Quailpox virus ...

*List of MeSH codes (B04)

... avipoxvirus MeSH B04.280.650.160.100.149 --- canarypox virus MeSH B04.280.650.160.100.300 --- fowlpox virus MeSH B04.280. ... avipoxvirus MeSH B04.909.204.783.160.100.149 --- canarypox virus MeSH B04.909.204.783.160.100.300 --- fowlpox virus MeSH ...

*List of invasive species in North America

Avipoxvirus (fowlpox) Batrachochytrium dendrobatidis (chytridiomycosis) Cryphonectria parasitica (chestnut blight) Flavivirus ( ...

*Raccoonpox virus

Avipoxvirus, Capripoxvirus, Leporipoxvirus, Molluscipoxvirus, Orthopoxvirus, Parapoxvirus, Suipoxvirus and Yatapoxvirus ...

*List of genera of viruses

Aurivirus Avastrovirus Avenavirus Aveparvovirus Aviadenovirus Avibirnavirus Avihepadnavirus Avihepatovirus Avipoxvirus ...

*Avipoxvirus

There is no one specific treatment used for birds who have contracted the avipoxvirus. Often the avipoxvirus acts as an immune ... Viralzone: Avipoxvirus Virus Pathogen Database and Analysis Resource (ViPR): Poxviridae Species Profile- Fowlpox (Avipoxvirus ... Avipoxvirus is a virus that is brick shaped and is usually 200 nanometres in diameter. This is much larger than normal viruses ... Avipoxvirus is a member of the Poxviridae family. The Poxviridae family is the family of viruses which cause the victim ...

*Category:Low-importance virus articles

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Paridae pox, a novel avipoxvirus infection, has recently been identified as an emerging infectious disease affecting wild tit species in Great Britain. The incursion of Paridae pox to a long-term study site where populations of wild tits have been monitored in detail for several decades provided a unique opportunity to obtain information on the local-scale epidemiological characteristics of this novel infection during a disease outbreak. Using captures of |8000 individual birds, we show that, within two years of initial emergence, Paridae pox had become established within the population of great tits (Parus major) reaching relatively high peak prevalence (10%), but was far less prevalent (|1%) in sympatric populations of several other closely related, abundant Paridae species. Nonlinear smoothing models revealed that the temporal pattern of prevalence among great tits was characterised by within-year fluctuations indicative of seasonal forcing of infection rates, which was likely driven by multiple
Advances in understanding the role of dendritic cells (DCs) as the major antigen (Ag)-presenting cell type of the immune system combined with the recent development of methods for the ex vivo expansion of human DCs have opened the possibility for the transfer of tumor Ags to DCs with a view toward tumor immunotherapy. In this study, we examined the feasibility of Ag transfer to cultured human DCs using the host range-restricted avipoxvirus, fowlpoxvirus (FWPV). FWPV was found to infect and express a lacZ marker gene in a number of mammalian cell lines of fibroblastic, epithelial, and hemopoietic lineage origins. LacZ recombinant FWPV (rFWPV) was found subsequently to infect human DCs that had been cultured ex vivo from peripheral blood monocytes. Using rFWPV containing lacZ under the control of a vaccinia virus (VV) early/late promoter (p7.5K) and a 10 plaque-forming units per cell multiplicity of infection, ,80% of cells expressed the lacZ marker gene. Quantitative analysis showed that the ...
AVIAN POX Cause. Poxvirus, several strains.. Host. Variety of birds worldwide: upland gamebirds, songbirds, marine birds, parrot family, occasionally raptors, rarely waterfowl.. Transmission. Direct contact with infected birds, ingestion of food and water contaminated by sick birds or carcasses, or contact with contaminated surfaces such as bird feeders and perches. The virus enters through abraded skin. Insects, especially mosquitoes, may act as mechanical vectors.. Clinical/Field Signs. Avian pox can occur in two forms: cutaneous pox and diphtheritic or "wet" pox. In cutaneous pox (the most common form), wartlike growths occur around the eyes, beak or any unfeathered skin. This leads to difficulty seeing, breathing, feeding, or perching. In diphtheritic pox, the growths form in the mouth, throat, trachea and lungs resulting in difficulty breathing or swallowing. Birds with either type may appear weak and emaciated.. Lesions. Warty growths on unfeathered skin, sometimes in large clusters. Size ...
Fowlpox is caused by Avipoxvirus genus Poxviridae family (a large DNA virus) the disease can be transmitted from virus carrier to naive poultry through wounds or spread virus to a nearby poultry house.
Read the latest Meridian stories, Garden birds under threat from new avian pox on ITV News, videos, stories and all the latest Meridian news
Las enfermedades introducidas han sido implicadas en extinciones y declinaciones poblacionales recientes en todo el mundo. Tanto el cambio inducido antropogénicamente como los atributos ambientales naturales pueden afectar la dispersión de la enfermedad. Más aun, la perturbación ambiental puede resultar en cambios en la fisiología del estrés, la nutrición y estructura social, que a su vez puede suprimir el funcionamiento del sistema inmune. Sin embargo, no se conoce si la variación del paisaje resulta en heterogeneidad de la resistencia del huésped a patógenos. El virus de la varicela aviar, un patógeno implicado en declinaciones y extinciones de aves en Hawái, fue introducido a las Galápagos en la década de 1890, y la prevalencia (número total de infecciones actuales) ha incrementado en los pinzones recientemente. Probamos si la prevalencia y las tendencias de recuperación en 7 especies de pinzones de las Galápagos variaron con la elevación y el uso de suelo por humanos. Para ...
GenDR A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling.. ...
Abcam provides specific protocols for Anti-Eph receptor A2 antibody [RM-0051-8F21] (ab73254) : Flow cytometry protocols, Immunoprecipitation protocols…
Phase Ib Trial of Intratumoral Injection of a Recombinant Canarypox Virus Encoding Human B7.1 (ALVAC-hB7.1) [ALVAC CEA] or a Combination of ALVAC-hB7.1 and a Recombinant Canarypox Virus Encoding Human Interleukin 12 (ALVAC-hIL-12) in Patients With Surgically Incurable Melanoma ...
In this thesis, two different vaccines were evaluated as adjuvant therapy for patients with colorectal cancer. The ability of the two candidate vaccines to generate antigen-specific cellular and humoral responses, respectively, was studied. The effectiveness of granulocyte colony stimulating factor (GM-CSF) as a cytokine adjuvant to augment the immune response was also examined.. The first vaccination strategy involved immunization with the recombinant tumor-associated protein, carcinoembryonic antigen (CEA). Recombinant CEA was administered at 4 different dose levels 7 times during one year. Peripheral blood samples were regularly analyzed during 36 months. This vaccination regimen induced a strong immunoglobulin 1 (IgG1) and IgG4 response, a moderate IgG2 response and a weak IgG3 response against CEA. GM-CSF markedly augmented the effect on IgG1 and IgG4 as well as the T cell response. In contrast, dose of rCEA had no or modest effect on induced immune responses. The response gradually ...
One of the earliest observations in the HIV epidemic was the demonstration of HIV infection at mucosal surfaces of cells in the genital tract. These data suggest that priming of immune defenses of viral infected cells may be an important component in the strategy of developing an effective HIV vaccine. Direct immunization of relevant mucosal surfaces with a vectored vaccine may stimulate mucosal immunity. The ALVAC-HIV vCP205 immunogen is constructed from a live recombinant canarypox vector that has a good safety profile in volunteers and should allow mucosal induction of immunity.. This randomized, double-blind trial evaluates the safety of and immune response to vaccination with ALVAC-HIV vCP205 given at 0, 1, 3, and 6 months. Patients are randomly assigned to 1 of 7 drug administration routes as follows:. Group A: Intramuscular Group B: Oral Group C: Intranasal Group D: Intrarectal Group E: Intravaginal Group F: Intranasal/intramuscular Group G: Intrarectal/intramuscular Twelve patients are ...
Mother-to-child transmission (MTCT) of HIV can be caused either by perinatal transmission of HIV or by breastfeeding, a common practice in poorer regions of the world. HIV preventive vaccines are currently under investigation as potential solutions to worldwide MTCT of HIV. This study will evaluate the safety and immunogenicity of an HIV-1 vaccine, ALVAC-HIV vCP1521, in infants born to HIV-1 infected mothers in Uganda. The vaccine is a preparation of a live attenuated recombinant canarypox virus, encoding HIV clades B and E envelope proteins. This study will be conducted at Mulago Hospital in Uganda.. Mothers will enroll in this study during their third trimesters of pregnancy. During screening, mothers will undergo medical history assessment, a physical exam, and blood collection. After delivery and prior to infant enrollment, mothers will have another physical exam; mothers and their infants will be accompanied home by a home visitor who will document contact information.. Infants will be ...
Viral vectors derived from different virus families, including poxvirus (canarypox virus vector ALVAC) and adenovirus (human Ad5 vector), have been widely used in vaccine development for a range of human diseases including HIV/AIDS. Less is known about the mechanisms underlying the host innate response to these vectors. Increasing evidence from clinical vaccine trials testing different viral vectors has suggested the importance of understanding basic elements of host-viral vector interactions. In this study, we investigated the innate interactions of APCs with two commonly used HIV vaccine vectors, ALVAC and Ad5, and identified AIM2 as an innate sensor for ALVAC, triggering strong inflammasome activation in both human and mouse APCs ...
Then the Thai government did an amazing thing: it acknowledged the importance of HIV, identified the source and instituted a prevention program, enforcing condom use in brothels. The impact was dramatic. Rates of infection declined precipitously and prevalence in sentinel populations fell. The epidemic was changing before a vaccine could be brought to the field. As incidence dropped, the trial had to become larger and compromises had to be introduced.. Initial plans called for optimizing both cellular and humoral HIV-specific responses using a "prime-boost" approach: a single prime (ALVAC-HIV, a CRF01-specific canarypox vaccine) was to be tested with three different boosts (subunit vaccines) in phase II trials from which the best regimen would be chosen for the Phase III trial. Shortly before the Phase II trials were complete, two of the manufacturers withdrew their products. The ALVAC-HIV + AIDSVAX B/E combination, the only regimen remaining, "passed" immunogenicity criteria for advancement to ...
Mouse monoclonal antibody raised against full length recombinant human Carcinoembryonic Antigen (CEA). Recombinant protein corresponding to full length human Carcinoembryonic Antigen. (MAB14723) - Products - Abnova
Models include: A 6-42, Al-6, B 10-42. B 15-42, B-17. B-17-LL. B-17, BI-17C, B50-42, B 60-42, Bl-60, B 70-42, BC 5-42, BC 6-42, B 50-42, B 60-42, Bl-60, B70-42, BC5-42, BC 6-42, RK-3, RK-3D, RK-3S, RK-4, RK-4D, RK-10, RK-20, RK-205, RK-40, RK-60, RK-70, R-15, R-17, RM-10, RM-17, RM-3, RM-4, RM-27, RM-30, RM-35, RM-65, RM-45, RL-45, RM-75, RO-10, RO-20, RO-20-2, RO-30, RO-35, RO-30-2, RO-35-2, RO-10-2, RO-12, RO-15-S, RO-40, RO-40-2, RO-50, RO-50-2, RO-60, RO-60-2, RO-70, RO-70-2 ...
موقعي كه زخم آبله در حنجره ايجاد مي شود، نفس كشيدن پرنده مشكل مي‌گردد. اغلب نفس نفس مي زند. اين حالت همزمان با ورود ويروس در خون ايجاد مي شود ولي اگر شدت ويروس و يا مقدار آن زياد باشد پرنده تلف مي‌گردد.. ترکیبات:. -ویال A (ویال جهت درمان موضعی):. Chloramphenicol…………… 4g. Excipient q.s. ………………100ml. -ویال B (ویال جهت درمان خوراکی):. Chloramphenicol…………….. 5,4g. Excipient q.s. ………………100ml. حیوانات هدف:. قناری، فنچ، طوطی، کبوتر و سایر پرندگان زینتی. میزان مصرف:. - تجویز در آب آشامیدنی ( ویال B) :. درمان می بایست در اولین زمان ممکن و از زمانی که احتمال بروز این بیماری وجود دارد، آغاز گردد.. میزان ...
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Manuscript submission - The only peer-reviewed journal focusing solely on the pathophysiology, recognition, and treatment of this major health condition.
Sanofi Pasteur announced the results of a Phase 3 trial with its HIV prime vaccine, ALVAC HIV (recombinant canarypox vCP1521) in combination with the booster AidsVax B/E (recombinant gp120 vaccine, from VaxGen).
protein common to the parapoxvirus, orthopoxvirus, leporipoxvirus and avipoxvirus genera has been identified, prepared by alkaline extraction of the virion. Subsequent investigations have shown four cross-reacting polypeptides between orthopoxviruses and leporipoxviruses, and one between capri-poxviruses and parapoxviruses. However, none of these are significant in cross-immunity between the genera.. Within the orthopoxviruses, there is good cross-immunity between all the members, exemplified by the use of vaccinia to protect against smallpox (variola). The antigens which stimulate protective antibodies are present in the surface tubular elements and in the envelope derived from modified cellular membrane that surrounds the naturally released virion. Virions released from disrupted cells lack this external membrane and are reported to be less infectious. The envelope also contains the glycoprotein hemagglutinin, which is common to all orthopoxviruses but absent from the other seven genera. ...
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TABLE-US-00002 [0080] TABLE 2 Paint ID Formulation 1 Formulation 2 Formulation 3 Formulation 4 Polymer ID Acrylic copolymer Acrylic copylymer Acrylic copolymer Acrylic copolymer Grind Surfactant Strodex TH-100/A-34 Strodex TH-100/A-34 Strodex TH-100/A-34 Strodex TH-100/A-34 Neutralizer NBDA NBDA NBDA AEPD Neutralizer Wt (lbs/100 gal) 4.1 4.1 4.1 3.06 Post-Add 0.875% FT-100 (BOPS) 0.875% FT-100 + 2.3% 0.875% FT-100 + 4.6% 0.875% FT-100 Cmpd 2 (BOPS) Cmpd 2 (BOPS) (BOPS) Post-Add Wt (lbs/100 gal) FT (2.16) FT (2.16), PHDA (5.0) FT (2.16) PHDA (10.0) FT (2.16) Optifilm % 3 3 3 3 ICI Build Acrysol RM-5000 Acrysol RM-5000 Acrysol RM-5000 Acrysol RM-5000 ICI Build Wt (lbs/100 gal) 40 40 40 40 KU Build Acrysol RM-895 Acrysol RM-895 Acrysol RM-895 Acrysol RM-895 KU Build Wt (lbs/100 gal) 3.0 3.0 3.0 3.0 Total RM Wt. 43 43 43 43 Initial KU 96 94 94 96 Initial ICI 1.3 1.3 1.3 1.40 Initial pH 8.80 8.98 9.05 8.80 Equil. KU 98 96 96 100 Equil. ICI 1.3 1.3 1.3 1.4 Equil. pH 8.83 9.06 9.13 8.85 ΔKU 2 2 2 4 ...
Salmonellosis, conjunctivitis, aspergillosis, avian pox, trichomoniasis. Droopiness, diarrhea, severe lethargy, lesions, swollen livers, abscesses. Mouth and throat sores, fungus in lungs and air sacs causing bronchitis and pneumonia, wartlike growths on featherless surfaces (can impair vision, ability to stand or perch).
Clone REA428 recognizes an epitope shared by the human CD66a, c, d, and e antigens, which are also known as the human carcinoembryonic antigen (CEA) family. The CEA family has 7 genes belonging to the CEACAM subgroup. These subgroup members are mainly associated with the cell membrane and show a complex expression pattern in normal and cancerous tissues. CD66a (CEACAM1) is an adhesion molecule that is involved in many immune responses associated with infection, inflammation, and cancer. It interacts homophilically with CD66a and heterophilically with CD66e (CEACAM5), but not with other CEACAM proteins. CD66a is expressed on a variety of cells, e.g., some epithelial cells, melanoma, and activated lymphocytes. Within the hematopoietic system, CD66c (CEACAM6) expression is limited to granulocytes and its precursors, where it serves homotypic and heterotypic adhesion and Ca2+ mediated signaling. It is markedly upregulated from intracellular stores after activatio and is also found in epithelia of various
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Rhythm announced today results demonstrating that RM-131, the companys novel ghrelin agonist, was highly effective in restoring normal gastric function in animal models of delayed
Aegithalidae: Aegithalidae, songbird family that includes the long-tailed tits (or titmice) of the Old World and the bushtits of North America. Both groups are considered subfamilies of the family Paridae (order Passeriformes) in some classifications. The eight species are small, arboreal insect eaters with
IOC Classification: Domain: Eukaryota • Regnum: Animalia • Phylum: Chordata • Subphylum: Vertebrata • Infraphylum: Gnathostomata • Superclassis: Tetrapoda • Classis: Aves • Superordo: Neognathae • Ordo: Passeriformes • Subordo: Passeri • Infraordo: Passerida • Superfamilia: Sylvioidea • Familia: Paridae • Genus: Periparus Selys-Longchamps, 1884 ...
Recombinant human monoclonal antibody raised against human carcinoembryonic antigen (CEA). Original antibody is raised against native purified human CEA. (RAB00036) - Products - Abnova
pock definition: A pustule brought on by smallpox or a similar eruptive disease.; A mark or scar remaining within the epidermis by such a pustule; a pockmark.; To mark with pocks; pit.; A pus filled inflammation…
Parapoxvirus, is commonly referred to as "farmyard pox" and is mostly expressed in hoofed animals. The virus belongs to the Poxviridae family. This infection is identified by scabby lesions that can be seen on the muzzle, lips, face, ears or on the velvet of the Red deer (Cervus elaphus). This virus is zoonotic, meaning infectious diseases of animals that can be transmitted to humans. Humans vulnerable to infection include farmers, butchers, and veterinarians. This virus occurs worldwide. In 1987, deaths[clarification needed] occurred on two Red Deer farms in New Zealand where secondary bacterial infections were seen alongside the lesions. In these particular cases, morbidity rates reached 100%. Parapoxvirus belongs to the family of viruses named Poxviridae, a group one family of double stranded DNA viruses. More specifically Parapoxvirus is classified into the subfamily of Chordopoxvirinae. Other Chordopoxvirinae genuses include; Orthopoxvirus, Avipoxvirus, Capripoxvirus, Leporipoxvirus, ...
When a person becomes the victim of chicken pox, he gets rid of this disease within 10-15 days. Marks of chicken pox left behind the disease disappear after 5-6 months.
Amongst the nitrogen sources, tryptone and yeast extract at 0.5% and 0.15% level, respectively, caused maximum enzyme production by Bacillus stearothermophilus RM-67. Addition of sodium chloride (0.5%) to the basal medium enhanced the enzyme production by 63%. Various sugars incorporated into the standardized basal medium proved inhibitory to enzyme elaboration. Maximum enzyme production was observed in the early decline growth phase of the organism in tryptone-yeast extract-salt medium (pH 6.5) when inoculated at 4% level and incubated on a rotary shaker at 55°C for 8 h and subsequently at 45°C up to 24 h. ...
The chicken pox virus can infect anybody, but it commonly targets children. Most reported cases occur in children under the age of 10. Heres more.
What Does Chicken Pox Look Like | Day 1 To 12 What Does Chicken Pox Look Like Find out what does chicken pox look like, I had two over a weekend!
hello , i am 22yrs old . I had chiken pox since many years ago , it was nearly in 2002 or 2004 . At that time i was having really many chicken pox on my full body . But now my question is do you think...
My four year old recently caught chicken pox (two weeks before we went to Disneyland!). As shes my third child, I had a pretty good idea of how to keep her comfortable. I did Google for advice, and s...
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Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors. - The Christie Research...Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors. - The Christie Research...

In this study, we examined the feasibility of Ag transfer to cultured human DCs using the host range-restricted avipoxvirus, ... In this study, we examined the feasibility of Ag transfer to cultured human DCs using the host range-restricted avipoxvirus, ... Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors.. Authors:. Brown, Michael D; ... Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors., 6 (3):238-45 Cancer Gene Ther. ...
more infohttp://christie.openrepository.com/christie/handle/10541/91418

Summary NotificationSummary Notification

Avipox virus. Fowlpox. POXVAX-TC. European Commission administrative information. Consent given by the Member State Competent ...
more infohttp://gmoinfo.jrc.ec.europa.eu/gmo_report.aspx?CurNot=B/GB/11/R44/01/W

Summary NotificationSummary Notification

PROSTVAC-F : Genus: Avipox Virus Species: Fowlpox. Information relating to the recipient or parental organisms from wich the ...
more infohttp://gmoinfo.jrc.ec.europa.eu/gmo_report.aspx?CurNot=B/EE/12/01

Epidemiology of the emergent disease Paridae pox in an intensively studied wild bird population. - Nuffield Department of...Epidemiology of the emergent disease Paridae pox in an intensively studied wild bird population. - Nuffield Department of...

... a novel avipoxvirus infection, has recently been identified as an emerging infectious disease affecting wild tit species in ... Paridae pox, a novel avipoxvirus infection, has recently been identified as an emerging infectious disease affecting wild tit ... Animals, Animals, Wild, Avipoxvirus, Bird Diseases, Confidence Intervals, Models, Biological, Passeriformes, Poxviridae ...
more infohttps://www.ndph.ox.ac.uk/publications/365573

Fowl pox - MAPHAVET Veterinary Joint Stock Company - thuốc thú y chất lượng caoFowl pox - MAPHAVET Veterinary Joint Stock Company - thuốc thú y chất lượng cao

Fowlpox is caused by Avipoxvirus genus Poxviridae family (a large DNA virus) the disease can be transmitted from virus carrier ... fowlpox is, caused by, avipoxvirus genus, poxviridae family, large dna, virus the, disease can, be transmitted, from virus, ... Fowlpox is caused by Avipoxvirus genus Poxviridae family (a large DNA virus). the disease can be transmitted from virus carrier ... Fowlpox is caused by Avipoxvirus genus Poxviridae family (a large DNA virus) the disease can be transmitted from virus carrier ...
more infohttp://marphavet.com/en/news/Disease-Treatment/Fowl-pox-82/

Avipoxvirus - WikipediaAvipoxvirus - Wikipedia

There is no one specific treatment used for birds who have contracted the avipoxvirus. Often the avipoxvirus acts as an immune ... Viralzone: Avipoxvirus Virus Pathogen Database and Analysis Resource (ViPR): Poxviridae Species Profile- Fowlpox (Avipoxvirus ... Avipoxvirus is a virus that is brick shaped and is usually 200 nanometres in diameter. This is much larger than normal viruses ... Avipoxvirus is a member of the Poxviridae family. The Poxviridae family is the family of viruses which cause the victim ...
more infohttps://en.wikipedia.org/wiki/Avipoxvirus

PLOS ONE: 110 Years of Avipoxvirus in the Galapagos IslandsPLOS ONE: 110 Years of Avipoxvirus in the Galapagos Islands

Beginning with samples collected in 1899, we observed cutaneous lesions consistent with Avipoxvirus on 226 (6.3%) specimens. ... were positive for Avipoxvirus, while alternative diagnoses for some of those testing negative by both methods were feather ...
more infohttp://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0015989

Genus Avipoxvirus | Springer for Research & DevelopmentGenus Avipoxvirus | Springer for Research & Development

... pet or wild birds are assigned largely by default to the Avipoxvirus genus within the subfamily Chordopoxvirinae of the family ... Poxviruses identified in skin lesions of domestic, pet or wild birds are assigned largely by default to the Avipoxvirus genus ... Boyle D.B. (2007) Genus Avipoxvirus. In: Mercer A.A., Schmidt A., Weber O. (eds) Poxviruses. Birkhäuser Advances in Infectious ... The safety profile of avipoxvirus recombinants for use as veterinary and human vaccines or therapeutics is now well established ...
more infohttps://rd.springer.com/chapter/10.1007/978-3-7643-7557-7_11

Identification of Clade E Avipoxvirus, Mozambique, 2016 - Volume 23, Number 9-September 2017 - Emerging Infectious Diseases...Identification of Clade E Avipoxvirus, Mozambique, 2016 - Volume 23, Number 9-September 2017 - Emerging Infectious Diseases...

Bányai K, Palya V, Dénes B, Glávits R, Ivanics É, Horváth B, et al. Unique genomic organization of a novel Avipoxvirus detected ... Avipoxvirus phylogenetics: identification of a PCR length polymorphism that discriminates between the two major clades. J Gen ... Phylogenetic analyses of the Avipoxvirus genus are usually conducted with the segments of the genes encoding the 4b core-like ... Avipoxviruses are large, enveloped DNA viruses that belong to the genus Avipoxvirus in the Chordopoxvirinae subfamily of the ...
more infohttps://wwwnc.cdc.gov/eid/article/23/9/16-1981

Figure - Identification of Clade E Avipoxvirus, Mozambique, 2016 - Volume 23, Number 9-September 2017 - Emerging Infectious...Figure - Identification of Clade E Avipoxvirus, Mozambique, 2016 - Volume 23, Number 9-September 2017 - Emerging Infectious...

Identification of Clade E Avipoxvirus, Mozambique, 2016 Lourenço P. Mapaco, Zeiss Lacerda, Iolanda V.A. Monjane, Esayas Gelaye ...
more infohttps://wwwnc.cdc.gov/eid/article/23/9/16-1981-f1

DIGITAL.CSIC: The biological background of a recurrently emerging infectious disease: prevalence, diversity and host...DIGITAL.CSIC: The biological background of a recurrently emerging infectious disease: prevalence, diversity and host...

In French Guiana Avipoxvirus prevalence was 0% (n = 889, 94 bird species). In Ecuador, prevalence was 0.3% (n = 941, 132 bird ... Avipoxvirus assemblages are composed of generalist strains with different ancestry and widespread distribution, a combination ... Next, we analyzed the host specificity and distribution of the worldwide Avipoxvirus diversity in order to understand their ... An analysis of the host specificity and geographic distribution of all Avipoxvirus strains known worldwide finds that these ...
more infohttps://digital.csic.es/handle/10261/157762

Possible incidence of avipoxvirus or other pathogen affecting Guatemalan birdsPossible incidence of avipoxvirus or other pathogen affecting Guatemalan birds

ESCOBAR-ANLEU, Bárbara I. et al. Possible incidence of avipoxvirus or other pathogen affecting Guatemalan birds. Huitzil [ ...
more infohttp://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S1870-74592019000200109&lng=es&nrm=iso&tlng=en

Possible incidence of avipoxvirus or other pathogen affecting Guatemalan birdsPossible incidence of avipoxvirus or other pathogen affecting Guatemalan birds

This widespread disease is found in a large number of bird families (The Wildlife Center of Virginia 2019). Most avipoxvirus ... at least of the genus Avipoxvirus, so clinical confirmation is required. This also would be the case of Catharus ustulatus and ... Possible incidence of avipoxvirus or other pathogen affecting Guatemalan birds. Huitzil 20(2): e-557. DOI: https://doi.org/ ...
more infohttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-74592019000200109&lng=en&nrm=iso&tlng=en

Virus-Taxonomie - WikipediaVirus-Taxonomie - Wikipedia

Genus Avipoxvirus. *Genus Capripoxvirus. *Genus Centapoxvirus. *Genus Cervidpoxvirus. *Genus Crocodylidpoxvirus. *Genus ...
more infohttps://de.wikipedia.org/wiki/Virus-Taxonomie

Immune Therapies and Anti-HIV Therapy Withdrawal in Controlling Viral Load - Full Text View - ClinicalTrials.govImmune Therapies and Anti-HIV Therapy Withdrawal in Controlling Viral Load - Full Text View - ClinicalTrials.gov

Avipoxvirus. Genetic Vectors. Viral Load. aldesleukin. Antiretroviral Therapy, Highly Active. HIV Therapeutic Vaccine. ...
more infohttps://clinicaltrials.gov/show/NCT00013663

The Big Picture Book of Viruses - Baltimore ListingThe Big Picture Book of Viruses - Baltimore Listing

Avipoxvirus. fowlpox virus. Vertebrates. Capripoxvirus. sheeppox virus. Vertebrates. Leporipoxvirus. myxoma virus. Vertebrates ...
more infohttp://www.virology.net/Big_Virology/BVFamilyGroup.html

Chordopoxvirinae - WikipediaChordopoxvirinae - Wikipedia

The genus Avipoxvirus diverged from the ancestor 249 ± 69 thousand years ago. The ancestor of the genus Orthopoxvirus was next ... The species in the genus Avipoxvirus infect birds; those in the genera Caiman poxvirus and Crocodylipoxvirus both infect ... Group: dsDNA Order: Unassigned Family: Poxviridae Sub-Family: Chordopoxvirinae Genus: Avipoxvirus Canarypox virus Fowlpox virus ...
more infohttps://en.wikipedia.org/wiki/Chordopoxvirinae

Patent US7507873 - Transgenic avians containing recombinant ovomucoid promoters - Google PatentsPatent US7507873 - Transgenic avians containing recombinant ovomucoid promoters - Google Patents

Recombinant avipox virus and method to induce an immune response. US5580859. Mar 18, 1994. Dec 3, 1996. Vical Incorporated. ... Recombinant avipox virus and immunological use thereof. US5175384. Dec 5, 1988. Dec 29, 1992. Genpharm International. ...
more infohttp://www.google.com/patents/US7507873?dq=5920316

UniProt: P10052UniProt: P10052

Avipoxvirus. OX NCBI_TaxID=928301; OH NCBI_TaxID=7742; Vertebrata. RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed= ...
more infohttps://www.genome.jp/dbget-bin/www_bget?uniprot:P10052

Difference between revisions of Poxviridae - microbewikiDifference between revisions of "Poxviridae" - microbewiki

The threats posed by the poxvirus have been effectively dealt with, leading to the eradication of the diseases caused by the virus. Smallpox had already been eradicated from most countries in Europe and the US by 1940s but it still posed a serious threat in the Indian subcontinent and much of Africa in the 1960s. The World Health Organization (WHO) decided to take strong actions for the eradication of the disease and listed smallpox on the top of the list for eradication in 1967. The WHO smallpox eradication unit was set up in the same year. After years of effort and investment into the eradication of smallpox, the last cases of variola major occured in the Indian subcontinent in 1975 while the last case of variola minor occured in Somalia in 1977. The last cases of smallpox occured in a Birmigam laboratory in 1979. Smallpox had been fought, and fought successfully. Smallpox has been eradicated globally but there are concerns about the potential use of variola virus as a weapon of terror. As a ...
more infohttps://microbewiki.kenyon.edu/index.php?title=Poxviridae&diff=prev&oldid=5230

Difference between revisions of Poxviridae - microbewikiDifference between revisions of "Poxviridae" - microbewiki

The threats posed by the poxvirus have been effectively dealt with, leading to the eradication of the diseases caused by the virus. Smallpox had already been eradicated from most countries in Europe and the US by 1940s but it still posed a serious threat in the Indian subcontinent and much of Africa in the 1960s. The World Health Organization (WHO) decided to take strong actions for the eradication of the disease and listed smallpox on the top of the list for eradication in 1967. The WHO smallpox eradication unit was set up in the same year. After years of effort and investment into the eradication of smallpox, the last cases of variola major occured in the Indian subcontinent in 1975 while the last case of variola minor occured in Somalia in 1977. The last cases of smallpox occured in a Birmigam laboratory in 1979. Smallpox had been fought, and fought successfully. Smallpox has been eradicated globally but there are concerns about the potential use of variola virus as a weapon of terror. As a ...
more infohttps://microbewiki.kenyon.edu/index.php?title=Poxviridae&diff=4687&oldid=4685

Northwest - Pacific IslandsNorthwest - Pacific Islands

Despite the purported role of avian pox (Avipoxvirus spp.) in the decline of endemic Hawaiian birds, few studies have been ...
more infohttps://www.usgs.gov/science/regions/northwest-pacific-islands?qt-regions_l2_landing_page_tabs=6
  • An analysis of the host specificity and geographic distribution of all Avipoxvirus strains known worldwide finds that these viruses are usually host generalists (particularly those in the fowlpox clade), and that many closely related strains are found on multiple continents. (csic.es)
  • Unlike other viruses, avipoxvirus can withstand extreme dryness. (wikipedia.org)
  • Avipoxvirus assemblages are composed of generalist strains with different ancestry and widespread distribution, a combination of characteristics which may make these typically scarce viruses perfect candidates to emerge under favorable ecological conditions. (csic.es)
  • In French Guiana Avipoxvirus prevalence was 0% (n = 889, 94 bird species). (csic.es)
  • Next, we analyzed the host specificity and distribution of the worldwide Avipoxvirus diversity in order to understand their invasion potential. (csic.es)
  • In this study, we examined the feasibility of Ag transfer to cultured human DCs using the host range-restricted avipoxvirus, fowlpoxvirus (FWPV). (openrepository.com)
  • The safety profile of avipoxvirus recombinants for use as veterinary and human vaccines or therapeutics is now well established. (springer.com)
  • The infection of avipoxvirus can lead to decreased egg production, reduced growth, blindness, and increased mortality in domestic poultry. (wikipedia.org)