Group of alpharetroviruses (ALPHARETROVIRUS) producing sarcomata and other tumors in chickens and other fowl and also in pigeons, ducks, and RATS.
A genus of the family RETROVIRIDAE with type C morphology, that causes malignant and other diseases in wild birds and domestic fowl.
Connective tissue tumors, affecting primarily fowl, that are usually caused by avian sarcoma viruses.
A group of replication-defective viruses, in the genus GAMMARETROVIRUS, which are capable of transforming cells, but which replicate and produce tumors only in the presence of Murine leukemia viruses (LEUKEMIA VIRUS, MURINE).
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl.
A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.
The functional hereditary units of VIRUSES.
Species of GAMMARETROVIRUS isolated from fibrosarcoma in cats. The viruses are actually recombinant feline leukemia viruses (FeLV) where part of the genome has been replaced by cellular oncogenes. It is unique to individuals and not transmitted naturally to other cats. FeSVs are replication defective and require FeLV to reproduce.
Common name for two distinct groups of BIRDS in the order GALLIFORMES: the New World or American quails of the family Odontophoridae and the Old World quails in the genus COTURNIX, family Phasianidae.
Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.
A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) capable of transforming mouse lymphoid cells and producing erythroid leukemia after superinfection with murine leukemia viruses (LEUKEMIA VIRUS, MURINE). It has also been found to transform cultured human fibroblasts, rat liver epithelial cells, and rat adrenocortical cells.
Proteins found in any species of virus.
A species of replication-competent oncogene-containing virus in the genus ALPHARETROVIRUS. It is the original source of the src oncogene (V-SRC GENES) and causes sarcoma in chickens.
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) isolated from a rhabdomyosarcoma by Moloney in 1966.
Ribonucleic acid that makes up the genetic material of viruses.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Deoxyribonucleic acid that makes up the genetic material of viruses.
An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A replication-defective mouse sarcoma virus (SARCOMA VIRUSES, MURINE) first described by J.J. Harvey in 1964.
Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.
Proteins from the family Retroviridae. The most frequently encountered member of this family is the Rous sarcoma virus protein.
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA.
A signal transducing adaptor protein that is encoded by the crk ONCOGENE from TYPE C AVIAN RETROVIRUSES. It contains SRC HOMOLOGY DOMAINS and is closely related to its cellular homolog, PROTO-ONCOGENE PROTEIN C-CRK.
A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
A genus of RETROVIRIDAE comprising endogenous sequences in mammals, related RETICULOENDOTHELIOSIS VIRUSES, AVIAN, and a reptilian virus. Many species contain oncogenes and cause leukemias and sarcomas.
Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.
Established cell cultures that have the potential to propagate indefinitely.
A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)
Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
A group of transmissible viral diseases of chickens and turkeys. Liver tumors are found in most forms, but tumors can be found elsewhere.
A species of GAMMARETROVIRUS producing tumors in primates. Originally isolated from a fibrosarcoma in a woolly monkey, WMSV is a replication-defective v-onc virus which carries the sis oncogene. In order to propagate, WMSV requires a replication-competent helper virus.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
A genus of BIRDS in the family Phasianidae, order GALLIFORMES, containing the common European and other Old World QUAIL.
Biologically functional sequences of DNA chemically synthesized in vitro.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Compounds which inhibit or antagonize biosynthesis or actions of integrase.
General name for the translation products of a fusion mRNA consisting of a gag gene and a viral oncogene (v-onc). These products are thought to have the ability to transform cells.
Viruses whose genetic material is RNA.
The sum of the weight of all the atoms in a molecule.
Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.
Proteins obtained from species of BIRDS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) arising during the propagation of S37 mouse sarcoma, and causing lymphoid leukemia in mice. It also infects rats and newborn hamsters. It is apparently transmitted to embryos in utero and to newborns through mother's milk.
An enzyme catalyzing the endonucleolytic cleavage of RNA at the 3'-position of a guanylate residue. EC 3.1.27.3.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A species of ALPHARETROVIRUS causing anemia in fowl.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
Process of growing viruses in live animals, plants, or cultured cells.
Viruses that produce tumors.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Substances elaborated by viruses that have antigenic activity.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Any of the covalently closed DNA molecules found in bacteria, many viruses, mitochondria, plastids, and plasmids. Small, polydisperse circular DNA's have also been observed in a number of eukaryotic organisms and are suggested to have homology with chromosomal DNA and the capacity to be inserted into, and excised from, chromosomal DNA. It is a fragment of DNA formed by a process of looping out and deletion, containing a constant region of the mu heavy chain and the 3'-part of the mu switch region. Circular DNA is a normal product of rearrangement among gene segments encoding the variable regions of immunoglobulin light and heavy chains, as well as the T-cell receptor. (Riger et al., Glossary of Genetics, 5th ed & Segen, Dictionary of Modern Medicine, 1992)
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected.
A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.
A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation techniques must first be isolated so that a process can be studied free from all of the complex side reactions that occur in a cell. The cell-free system is therefore widely used in cell biology. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p166)
The expelling of virus particles from the body. Important routes include the respiratory tract, genital tract, and intestinal tract. Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
An amino acid that occurs in endogenous proteins. Tyrosine phosphorylation and dephosphorylation plays a role in cellular signal transduction and possibly in cell growth control and carcinogenesis.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
DNA sequences that form the coding region for proteins associated with the viral core in retroviruses. gag is short for group-specific antigen.
A general term for diseases produced by viruses.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
A species in the group RETICULOENDOTHELIOSIS VIRUSES, AVIAN of the genus GAMMARETROVIRUS that causes a chronic neoplastic and a more acute immunosuppressive disease in fowl.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
A genus in the family RETROVIRIDAE infecting fish. Species include Walleye dermal sarcoma virus, Walleye epidermal hyperplasia virus 1, and Walleye epidermal hyperplasia virus 2.
Viruses parasitic on plants higher than bacteria.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Viruses whose nucleic acid is DNA.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.
A species of GAMMARETROVIRUS causing leukemia, lymphosarcoma, immune deficiency, or other degenerative diseases in cats. Several cellular oncogenes confer on FeLV the ability to induce sarcomas (see also SARCOMA VIRUSES, FELINE).
The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.
A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.
Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
A group of adenine ribonucleotides in which the phosphate residues of each adenine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The type species of LYSSAVIRUS causing rabies in humans and other animals. Transmission is mostly by animal bites through saliva. The virus is neurotropic multiplying in neurons and myotubes of vertebrates.
A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.
The small RNA molecules, 73-80 nucleotides long, that function during translation (TRANSLATION, GENETIC) to align AMINO ACIDS at the RIBOSOMES in a sequence determined by the mRNA (RNA, MESSENGER). There are about 30 different transfer RNAs. Each recognizes a specific CODON set on the mRNA through its own ANTICODON and as aminoacyl tRNAs (RNA, TRANSFER, AMINO ACYL), each carries a specific amino acid to the ribosome to add to the elongating peptide chains.
Electrophoresis in which agar or agarose gel is used as the diffusion medium.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
The rate dynamics in chemical or physical systems.
An extramedullary tumor of immature MYELOID CELLS or MYELOBLASTS. Granulocytic sarcoma usually occurs with or follows the onset of ACUTE MYELOID LEUKEMIA.
A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 3 and neuraminidase 2. The H3N2 subtype was responsible for the Hong Kong flu pandemic of 1968.
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
A highly malignant subset of neoplasms arising from the endometrial stroma. Tumors in this group infiltrate the stroma with a wide range of atypia cells and numerous mitoses. They are capable of widespread metastases (NEOPLASM METASTASIS).
A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE). It can infect birds and mammals. In humans, it is seen most frequently in Africa, Asia, and Europe presenting as a silent infection or undifferentiated fever (WEST NILE FEVER). The virus appeared in North America for the first time in 1999. It is transmitted mainly by CULEX spp mosquitoes which feed primarily on birds, but it can also be carried by the Asian Tiger mosquito, AEDES albopictus, which feeds mainly on mammals.
Retroviral proteins, often glycosylated, coded by the envelope (env) gene. They are usually synthesized as protein precursors (POLYPROTEINS) and later cleaved into the final viral envelope glycoproteins by a viral protease.
A sarcoma of young, often female, adults of the lower extremities and acral regions, intimately bound to tendons as circumscribed but unencapsulated melanin-bearing tumors of neuroectodermal origin. An ultrastructural finding simulates flattened and curved barrel staves, corresponding to the internal structures of premelanosomes. There is a 45-60% mortality in clear cell sarcoma. (Segen, Dictionary of Modern Medicine, 1992)
A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children.
A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. Humans and cattle are most affected but infections in goats and sheep have also been reported.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
The type species of VESICULOVIRUS causing a disease symptomatically similar to FOOT-AND-MOUTH DISEASE in cattle, horses, and pigs. It may be transmitted to other species including humans, where it causes influenza-like symptoms.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.
Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.
Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.
Retroviral proteins that have the ability to transform cells. They can induce sarcomas, leukemias, lymphomas, and mammary carcinomas. Not all retroviral proteins are oncogenic.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.

Inhibition of the rous sarcoma virus long terminal repeat-driven transcription by in vitro methylation: different sensitivity in permissive chicken cells versus mammalian cells. (1/1585)

Rous sarcoma virus (RSV) enhancer sequences in the long terminal repeat (LTR) have previously been shown to be sensitive to CpG methylation. We report further that the high density methylation of the RSV LTR-driven chloramphenicol acetyltransferase reporter is needed for full transcriptional inhibition in chicken embryo fibroblasts and for suppression of tumorigenicity of the RSV proviral DNA in chickens. In nonpermissive mammalian cells, however, the low density methylation is sufficient for full inhibition. The time course of inhibition differs strikingly in avian and mammalian cells: although immediately inhibited in mammalian cells, the methylated RSV LTR-driven reporter is fully inhibited with a significant delay after transfection in avian cells. Moreover, transcriptional inhibition can be overridden by transfection with a high dose of the methylated reporter plasmid in chicken cells but not in hamster cells. The LTR, v-src, LTR proviral DNA is easily capable of inducing sarcomas in chickens but not in hamsters. In contrast, Moloney murine leukemia virus LTR-driven v-src induces sarcomas in hamsters with high incidence. Therefore, the repression of integrated RSV proviruses in rodent cells is directed against the LTR.  (+info)

HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro. (2/1585)

We have reconstituted concerted human immunodeficiency virus type 1 (HIV-1) integration in vitro with specially designed mini-donor HIV-1 DNA, a supercoiled plasmid acceptor, purified bacterium-derived HIV-1 integrase (IN), and host HMG protein family members. This system is comparable to one previously described for avian sarcoma virus (ASV) (A. Aiyar et al., J. Virol. 70:3571-3580, 1996) that was stimulated by the presence of HMG-1. Sequence analyses of individual HIV-1 integrants showed loss of 2 bp from the ends of the donor DNA and almost exclusive 5-bp duplications of the acceptor DNA at the site of integration. All of the integrants sequenced were inserted into different sites in the acceptor. These are the features associated with integration of viral DNA in vivo. We have used the ASV and HIV-1 reconstituted systems to compare the mechanism of concerted DNA integration and examine the role of different HMG proteins in the reaction. Of the three HMG proteins examined, HMG-1, HMG-2, and HMG-I(Y), the products formed in the presence of HMG-I(Y) for both systems most closely match those observed in vivo. Further analysis of HMG-I(Y) mutants demonstrates that the stimulation of integration requires an HMG-I(Y) domain involved in DNA binding. While complexes containing HMG-I(Y), ASV IN, and donor DNA can be detected in gel shift experiments, coprecipitation experiments failed to demonstrate stable interactions between HMG-I(Y) and ASV IN or between HMG-I(Y) and HIV-1 IN.  (+info)

Protective effects of type I and type II interferons toward Rous sarcoma virus-induced tumors in chickens. (3/1585)

Growth of tumors induced by Rous sarcoma virus (RSV) is controlled by alleles at the major histocompatibility complex locus in chickens, indicating that immunological host defense mechanisms play a major role. We show here that the resistance phenotype of CB regressor chickens can be partially reverted by treating the animals with a monoclonal antibody that neutralizes the major serotype of chicken type I interferon, ChIFN-alpha. Injection of recombinant ChIFN-alpha into susceptible CC progressor chickens resulted in a dose-dependent inhibition of RSV-induced tumor development. This treatment was not effective, however, in CC chickens challenged with a DNA construct expressing the v-src oncogene, suggesting that the beneficial effect of type I interferon in this system resulted from its intrinsic antiviral activity and probably not from indirect immunmodulatory effects. By contrast, recombinant chicken interferon-gamma strongly inhibited tumor growth when given to CC chickens that were challenged with the v-src oncogene, indicating that the two cytokines target different steps of tumor development.  (+info)

The role of overlapping U1 and U11 5' splice site sequences in a negative regulator of splicing. (4/1585)

Splicing of Rous sarcoma virus RNA is regulated in part by a cis-acting intronic RNA element called the negative regulator of splicing (NRS). An NRS mutant affecting nt 916-923 disrupts U11 snRNP binding and reduces NRS activity (Gontarek et al., 1993, Genes & Dev 7:1926-1936). However, we observed that a U15' splice site-like sequence, which overlapped the U11 site, was also disrupted by this mutation. To determine whether the U1 or the U11 site was essential for NRS activity, we analyzed twelve additional mutants involving nt 915-926. All mutations that disrupted the potential base pairing between U1 snRNA and the NRS reduced NRS activity, including single point mutations at nt 915, 916, and 919. The point mutation at nt 919 was partially suppressed by a compensatory base change mutation in U1 snRNA. In contrast, a mutation which strengthened the potential base pairing between the U1 site and the NRS increased NRS activity. Surprisingly, mutations that specifically targeted the U115' splice site consensus sequence increased the levels of unspliced RNA, suggesting U11 binding plays an antagonistic role to NRS activity. We propose that U1 snRNP binding to the NRS inhibits splicing and is regulated by U11 snRNP binding to the overlapping sequence. Competition between U1 and U11 snRNPs would result in the appropriate balance of spliced to unspliced RNAs for optimal viral replication. Further, a virus mutated in the U1/U11 region of the NRS was found to have delayed replication.  (+info)

Transgenic mice ubiquitously expressing human placental alkaline phosphatase (PLAP): an additional reporter gene for use in tandem with beta-galactosidase (lacZ). (5/1585)

A fundamental keystone of developmental biology has been the growing use of reporter genes in model transgenic systems. Their use has greatly facilitated investigations of cell lineage and cell fate in addition to aiding experiments aimed at determining patterns of gene expression, gene interaction and gene regulation. Through construction of transgenic mice, ubiquitously expressing human placental alkaline phosphatase (PLAP), we demonstrate the suitability of PLAP as a reporter gene for use in conjunction with, or as an alternative to, beta-galactosidase (lacZ). Our findings demonstrate that over-expression of PLAP has no adverse effects on mouse development or viability, despite a widespread pattern of expression. This technology provides a simple yet effective mechanism based on eukaryotic reporter gene technology to facilitate the identification of transgenic cells within complex in vivo systems.  (+info)

A mutant form of the rho protein can restore stress fibers and adhesion plaques in v-src transformed fibroblasts. (6/1585)

The organization of polymerized actin in the mammalian cell is regulated by several members of the rho family. Three rho proteins, cdc42, rac and rho act in a cascade to organize the intracellular actin cytoskeleton. Rho proteins are involved in the formation of actin stress fibers and adhesion plaques in fibroblasts. During transformation of mammalian cells by oncogenes the cytoskeleton is rearranged and stress fibers and adhesion plaques are disintegrated. In this paper we investigate the function of the rho protein in RR1022 rat fibroblasts transformed by the Rous sarcoma virus. Two activated mutants of the rho protein, rho G14V and rho Q63L, and a dominant negative mutant, rho N1171, were stably transfected into RR1022 cells. The resulting cell lines were analysed for the organization of polymerized actin and adhesion plaques. Cells expressing rho Q63L, but not rho wt, rho G14V or rho N1171, showed an altered morphology. These cells displayed a flat, fibroblast like shape when compared with the RR1022 ancestor cells. Immunofluorescence analyses revealed that actin stress fibers and adhesion plaques were rearranged in these cells. We conclude from these data that an active rho protein can restore elements of the actin cytoskeleton in transformed cells by overriding the tyrosine kinase phosphorylation induced by the pp60(v-src).  (+info)

Molecular dynamics studies on the HIV-1 integrase catalytic domain. (7/1585)

The HIV-1 integrase, which is essential for viral replication, catalyzes the insertion of viral DNA into the host chromosome, thereby recruiting host cell machinery into making viral proteins. It represents the third main HIV enzyme target for inhibitor design, the first two being the reverse transcriptase and the protease. Two 1-ns molecular dynamics simulations have been carried out on completely hydrated models of the HIV-1 integrase catalytic domain, one with no metal ions and another with one magnesium ion in the catalytic site. The simulations predict that the region of the active site that is missing in the published crystal structures has (at the time of this work) more secondary structure than previously thought. The flexibility of this region has been discussed with respect to the mechanistic function of the enzyme. The results of these simulations will be used as part of inhibitor design projects directed against the catalytic domain of the enzyme.  (+info)

Biodegradable alginate microspheres as a delivery system for naked DNA. (8/1585)

Sodium alginate is a naturally occurring polysaccharide that can easily be polymerized into a solid matrix to form microspheres. These biodegradable microspheres were used to encapsulate plasmid DNA containing the bacterial beta-galactosidase (LacZ) gene under the control of either the cytomegalovirus (CMV) immediate-early promoter or the Rous sarcoma virus (RSV) early promoter. Mice inoculated orally with microspheres containing plasmid DNA expressed LacZ in the intestine, spleen and liver. Inoculation of mice with microspheres containing both the plasmid DNA and bovine adenovirus type 3 (BAd3) resulted in a significant increase in LacZ expression compared to those inoculated with microspheres containing only the plasmid DNA. Our results suggest that adenoviruses are capable of augumenting transgene expression by plasmid DNA both in vitro and in vivo.  (+info)

TY - JOUR. T1 - Creation and expression of myristylated forms of Rous sarcoma virus Gag protein in mammalian cells. AU - Wills, John. AU - Craven, Rebecca. AU - Achacoso, J. A.. PY - 1989. Y1 - 1989. N2 - Rous sarcoma virus (RSV), a member of the avian sarcoma and leukosis family of retroviruses, has long been known to be capable of infecting and transforming mammalian cells; however, such transformed cells do not release virus particles. The RSV gag product (Pr76(gag)) produced in these cells is not released into the culture medium or proteolytically processed to release mature products. Thus, the behavior of Pr76(gag) in mammalian cells is much like that of mammalian retroviral Gag proteins which have been altered so as to block the addition of myristic acid at residue 2 (Gly). Because the RSV gag product does not possess a myristic acid addition site, we hypothesized that the creation of one by oligonucleotide-directed mutagenesis might permit particles to be released from mammalian cells. ...
Hamster cells transformed with the Schmidt-Ruppin strain of avian sarcoma virus were selected for resistance to ethidium bromide (EB). The resistant cell lines proliferated in the presence of up to 30 µg/ml EB.. From avian sarcoma virus-transformed hamster cells already resistant to bromodeoxy-uridine (BrdU), ethidium bromide-resistant cells which were able to grow in 10 µg/ml EB were also prepared. These cells remain deficient in thymidine kinase activity and are suitable for selective preparation of hybrid cells.. The EB resistance was genetically stable. The EB-resistant cell lines, and doubly resistant cells (BrdU, EB) showed no differences in mitochondrial ultrastructure compared with the original cell lines. Thymidine incorporation into mitochondrial DNA was not influenced by EB resistance.. All resistant cell lines, including the doubly resistant cell line, contained the avian sarcoma virus genome. The number of cells needed for positive rescue experiments for avian sarcoma virus genome ...
The mature cores of all retroviruses contain a major structural protein known as the CA (capsid) protein. Although it appears to form a shell around the ribonucleoprotein complex that contains the viral RNA, its function in viral replication is largely unknown. Little sequence similarity exists between the CA proteins of different retroviruses, except for a region of about 20 amino acids termed the major homology region (MHR). To examine the role of the CA protein in particle assembly and release, mutants of Rous sarcoma virus were created in which segments of CA were deleted or single conserved residues in the MHR were altered. The ability of the deletion mutants to release particles at rates similar to the wild-type protein demonstrated that the CA domain of Gag is not an essential component of the minimal budding machinery. Certain point mutations in the MHR region did block assembly and release in certain cell types, presumably by perturbing the global structure of the Gag precursor. Another ...
Balk, Samuel D. et al Thymidine and Hypoxanthine Requirements for the Proliferation of Normal and Rous Sarcoma Virus-infected Chicken Fibroblasts in the Presence of Methotrexate. Cancer Research 39.5 (1979): 1854-1856. Web. 23 Feb. 2018. ...
Rous sarcoma virus definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
TY - CHAP. T1 - Rous sarcoma virus. T2 - Contributions of a chicken virus to tumor biology, human cancer therapeutics, and retrovirology. AU - Parent, Leslie J.. PY - 2012/12/13. Y1 - 2012/12/13. UR - http://www.scopus.com/inward/record.url?scp=84870746639&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84870746639&partnerID=8YFLogxK. U2 - 10.1007/978-1-4614-0016-5_28. DO - 10.1007/978-1-4614-0016-5_28. M3 - Chapter. AN - SCOPUS:84870746639. SN - 9781441999993. T3 - Current Cancer Research. SP - 705. EP - 737. BT - Cancer Associated Viruses. A2 - Robertson, Erle. A2 - Jasmin, Jean-Francois. A2 - Lisanti, Michael. ER - ...
Whitmore, A C.; Babcock, G F.; and Haughton, G, Genetic control of susceptibility of mice to rous sarcoma virus tumorigenesis. II. Segregation analysis of strain a.sw- -associated Resistance to primary tumor induction. (1978). Subject Strain Bibliography 1978. 4038 ...
This line was derived from an AtT-20ins cell line in which the Rous sarcoma virus long terminal repeat was used for directing insulin cDNA expression.
Transcription from the Rous sarcoma virus (RSV) Long terminal repeat (LTR) in untransformed rat 3Yl fibroblasts is dependent on the presence of serum. Within an hour of addition of serum to a serum-deprived culture there is a 5 fold stimulation in the level of transcripts initiated at the LTR. This stimulation does not require synthesis of new proteins. Mutations in the RSV LTR revealed that serum-stimulated transcription was mostly dependent on two CCAAT boxes in the LTR, though other upstream sequences may play a secondary role. Serum caused the rapid appearance of a nuclear protein that binds to the two CCAAT boxes. This serum-induced CCAAT factor was also bound by CCAAT sequences from other promoters, e.g. those of human heat shock protein 70, human c-Ha-ras, human histone 1 etc, but not by the adenovirus origin of replication, or the SV40 enhancer core sequence. This data suggests that the serum induced CCAAT factor is related to CPl or CP2 rather than the NFl or CjEBP types of CCAAT binding
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A series of six experiments involving a total of 1627 birds from four genetic lines known to differ in their resistance to Rous sarcoma virus (RSV) were conducted. In experiment one, the relationship between transplantation and tumor immunity was studied. Five day-old male chicks of the RSV-susceptible incross line (IC) were given random skin allografts which were scored for survival and feather growth at weekly intervals. Birds which showed either rapid graft rejection by four weeks postgrafting or profusely feathered accepted grafts by seven weeks postgrafting, were challenged with RSV when they reached eight weeks of age. Resulting tumors were scored at weekly intervals through 12 weeks postchallenge and a daily record of mortality was maintained. Mortality and mean survival time (MST) in birds accepting skin allografts were 94.92% and 41.58 ± 8.08 days compared to 66.67% and 24.49 ± 4.415 days for birds rejecting skin allografts, respectively. These differences in mortality and MST were ...
Vogt, P.K., Neil, J.C. , Moscovici, C. and Breitman, M.L. (1981) PRCII, a representative of a new class of avian sarcoma viruses. In: Neth, R., Gallo, R.C., Graf, T., Mannweiler, K. and Winkler, K. (eds.) Modern Trends in Human Leukemia IV. Series: Haematology and blood transfusion, 26. Springer, pp. 424-428. ISBN 9783540106227 (doi:10.1007/978-3-642-67984-1_77) ...
In their classic paper on the identification of the transforming principle of Rous sarcoma virus (RSV) published 1970 in PNAS (1), Peter Duesberg at the University of California, Berkeley, and Peter Vogt, then at the University of Washington, Seattle, drew a seemingly simple yet groundbreaking conclusion. When they analyzed the genomic RNAs of transforming, acutely oncogenic RSV and of transformation-defective (td) mutant derivatives, they found that all transforming virus stocks contained two classes of RNA subunits, a larger one (a) and a smaller one (b), whereas the nontransforming yet replication-competent mutants contained the smaller b subunits only. Duesberg and Vogt concluded that the larger a subunit contained the transforming principle of RSV. Based on this and on subsequent structural comparisons of the a and b subunits of biologically cloned viruses, the transforming principle was defined by the remarkably simple equation a − b = x and was later termed src (for sarcoma). The first ...
The SRC gene is similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and…
Three-time world 1,500m champion Asbel Kiprop is confident the mixed relay squad will weather the storm when called upon during the 42nd IAAF World Cross Country Championships in Kampala, Uganda, on Sunday.
Four previously uncharacterized avian sarcoma viruses were screened and two of these, RPL30 and CTIO, were found to encode apparently novel oncogenes. Biologically active CTIO DNA was molecularly cloned and the nucleotide sequence was determined. The CTIO genome encodes a gag-fusion polypeptide of 47 kilodaltons, termed p47gag-crk. This protein contains blocks of sequence similarity to a noncatalytic, potentially regulatory region found in the nonreceptor tyrosine kinases, a phosphoinositide-specific phospholipase C, and the ras GTPase activator protein; no homology was found to any known catalytic domain. Potential roles for the homologous domains, termed SH2 and SH3, in normal signal transduction and in the biological activity of p47gag-crk are discussed. Biochemical data demonstrated that phosphotyrosine levels on at least three cellular proteins were greatly elevated in CTI0-infected cells, and that a tyrosine kinase activity was immunoprecipitated in association with p47gag-crk. A specific
Proteins encoded by oncogenes such as v-fps/fes, v-src, v-yes, v-abl, and v-fgr are cytoplasmic protein tyrosine kinases which, unlike transmembrane receptors, are localized to the inside of the cell. These proteins possess two contiguous regions of sequence identity: a C-terminal catalytic domain of 260 residues with homology to other tyrosine-specific and serine-threonine-specific protein kinases, and a unique domain of approximately 100 residues which is located N terminal to the kinase region and is absent from kinases that span the plasma membrane. In-frame linker insertion mutations in Fujinami avian sarcoma virus which introduced dipeptide insertions into the most stringently conserved segment of this N-terminal domain in P130gag-fps impaired the ability of Fujinami avian sarcoma virus to transform rat-2 cells. The P130gag-fps proteins encoded by these transformation-defective mutants were deficient in protein-tyrosine kinase activity in rat cells. However v-fps polypeptides derived
6.2. Viral Carcinogenesis. Carcinogenesis is the mechanisms whereby viruses cause cancer that virus carried out a gene altered the cell regulation. Example of viruses that contribute to carcinogenesis.. There are two classes of tumour viruses: RNA viruses and DNA viruses.. 6.2.1. RNA viruses. RNA virus infect competent cells. Their RNA is converted into DNA that incorporated into the host genome. Hence, that is classification as retroviruses. Example of retrovirus: human T-lymphotropic virus(HTLV-1) and Rous sarcoma virus(RSV). RNA viruses show two general ways: provision of an oncogene or insertional mutagenesis in which regulatory sequences alter host gene activity.. Provision of an oncogene: Many oncogenic RNA viruses contain an oncogene additional to the sequences for viral replication. The Rous sarcoma virus, in which the oncogene v-src codes for a 60 kDa phoshoprotein(pp60src) that has tyrosine kinase activity.. Insertional mutagenesis: Mouse mammary tumour virue(MMTV) has regulatory ...
1D1D: Solution structure and dynamics of the Rous sarcoma virus capsid protein and comparison with capsid proteins of other retroviruses.
Click to launch & play an online audio visual presentation by Prof. Raymond Erikson on Three decades of protein phosphorylation and cancer: the identification and characterization of the src gene product, part of a collection of online lectures.
A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine ...
Supplier: ProMab Technologies Type of Product: Monoclonal Antibody Description: SRC: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian). This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The
1. Butel JS, Brugge JS, Noonan CA. Transformation of primate and rodent cells by temperature-sensitive mutants of SV40. Cold Spring Harb Symp Quant Biol. 1975;39 Pt 1:25-36. PMID: 169066. 2. Brugge JS, Butel JS. Role of simian virus 40 gene A function in maintenance of transformation. J Virol. 1975;15(3):619-35. PMCID: 354498.. 3. Vollett J, Brugge JS, and Butel JS. Temperature-dependent microfilament alterations in cells transformed by group A mutants of SV40. J. Cell. Biol. 67:114 (1975).. 4. Noonan CA, Brugge JS, Butel JS. Characterization of simian cells tranformed by temperature-sensitive mutants of simian virus 40. J Virol. 1976;18(3):1106-19. PMCID: 354810.. 5. Vollet JJ, Brugge JS, Noonan CA, Butel JS. The role of SV40 gene A in the alteration of microfilaments in transformed cells. Exp Cell Res. 1977;105(1):119-26. PMID: 190024. 6. Erikson E, Brugge JS, Erikson RL. Phosphorylated and nonphosphorylated forms of avian sarcoma virus polypeptide p19. Virology. 1977;80(1):177-85. PMID: ...
CrkL antibody (v-crk avian sarcoma virus CT10 oncogene homolog-like) for IHC-P, WB. Anti-CrkL pAb (GTX32539) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
The age of the chicken in which the Rous sarcoma is grown has an influence on the variation and subsequent adaptation of the causative virus to ducks. Adaptation is relatively easy to accomplish when the tumor has been grown in adult chickens several months of age. It has never been accomplished when the tumor has been grown in chicks and only occasionally when it has been grown in old chickens. ...
simarolide: quassinoid which inhibits incorporation of thymidine into chick embryo fibroblasts by Rous sarcoma virus; RN given is from 9th CI Chem Form Index; structure in first source
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
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The host ranges of the Rous sarcoma virus (RSV) pseudotype RSV(HPRS-103) of a novel avian leukosis virus (ALV), strain HPRS-103, and representative RSV pseudotypes of subgroups A to F, have been determined in embryo fibroblasts from 12 avian species. Domestic fowl, red jungle fowl, Sonnerat's jungle fowl and turkey were susceptible to infection by RSV(HPRS-103); ring-necked pheasant, Japanese green pheasant, golden pheasant, Japanese quail, guinea-fowl, Peking duck, Muscovy duck and goose were resistant. The host range pattern of RSV(HPRS-103) differs from those of viruses of subgroups A to G and I, and provides support for placing the HPRS-103 strain of ALV in a new envelope subgroup, designated J.
Chick embryo fibroblasts infected with Rous sarcoma virus in vitro are rendered malignant for such cells produce typical Rous sarcomas when injected into susceptible chicks since the tumors produced predominantly retain the sex chromatin patterns of the donor cells when such cells are injected into a recipient of the opposite sex. However, examination of the sex chromatin of cells at the periphery of the tumor shows presence of recipient cells though the bulk of the tumor is clearly of donor cell origin. Such tumors grow and cause death of the recipient. Injection of RSV induces tumors of the sex of the recipient as also does the injection of transformed cells rendered incapable of multiplication by x-rays. Following their injection into susceptible chicks, the cells transformed in vitro by virus behave in the same manner as tumor cells obtained from tumors induced by virus in vivo and cultivated in the same conditions in vitro.. When such tumors induced by transformed cells are serially ...
The protein kinase activity associated with pp60src, the transforming protein of RSV, phosphorylates tyrosine when assayed in an immunoprecipitate. This observation is surprising because protein modification by way of phosphorylation of tyrosine is unprecedented (28, 29). It is nonetheless real. We have found that chicken cells (Table 1) and mouse, rat, and hamster cells (data not shown) all contain readily detectable amounts of Tyr(P). This modified amino acid appears to have escaped detection before because it is rare (phosphoserine and phosphothreonine together being about 3000 times more abundant) and because it and phosphothreonine are difficult to separate by traditional electrophoretic procedures. Because there is a 7-fold increase in the abundance of Tyr(P) in proteins in cells transformed by RSV and because pp60src itself contains Tyr(P), it seems likely that pp60src phosphorylates tyrosine in vivo as well as in vitro. We suggest that pp60src is a protein kinase and that the ...
Summary Peripheral blood lymphocytes of chickens bearing tumours induced by avian sarcoma virus can be specifically stimulated to divide by the crude culture fluids of virus-infected cells. In this communication, we show that relevant antigenic activity apparently resides in each of the internal virus proteins p15 and p27. The ability of infectious culture fluids to be mitogenic for sensitized lymphocytes is greatly reduced following treatment with antibodies specific for either total avian myeloblastosis virus (AMV) protein or for p27.
v-Src is a gene found in Rous sarcoma virus that encodes a tyrosine kinase that causes a type of cancer in chickens. The src gene is oncogenic as it triggers uncontrolled growth in abnormal host cells. It was the first retroviral oncogene to be discovered. The src gene was taken up by RSV and incorporated into its genome conferring it with the advantage of being able to stimulate uncontrolled mitosis of host cells, providing abundant cells for fresh infection. The src gene is not essential for RSV proliferation but it greatly increases virulence when present. Francis Peyton Rous first proposed that viruses can cause cancer. He proved it in 1911 and was later awarded the Nobel prize in 1966. Chickens grow a tumor called a fibrosarcoma. Rous collected and ground up these sarcomas, and then centrifuged them to remove the solid material. Next, the remaining liquid mixture was injected into chicks. The chicks developed sarcomas. The causative agent in the liquid was a virus, this is now called the ...
Arthur D. Levinson, Ph.D., Chairman of Genentech, has replaced Steve Jobs as Chairman of the Board of Apple, Inc. During his scientific career, Levinson did research on different viruses, including adenovirus, retroviruses, and hepatitis B virus. His first virology paper came from his Ph.D. research with Arnold Levine, and is entitled In vivo and in vitro phosphorylation of the adenovirus type 5 single strand-specific DNA-binding protein. He moved to the University of California, San Francisco for postdoctoral work with Harold Varmus and Michael Bishop. There he published on the transforming gene of the retrovirus avian sarcoma virus. This PubMed search string will return Levinsons publications on viruses, of which there are approximately 35. Levinson left virology to work at Genentech in 1980, but clearly could be called a bona fide virologist. Who would have known that Steve Jobs would be replaced by a virologist?. Thanks to Alice Telesnitsky for pointing out this story.. ...
Tumor viruses Tumor viruses are those viruses that are able to infect cells and cause changes within the cells operating machinery such that the cells ability to regulate its growth and division is destroyed and the cells become cancerous. Human papillomavirus, hepatitis B, Epstein-Barr virus , human T-cell leukemia virus , SV-40, and Rous sarcoma virus are all tumor viruses. Source for information on Tumor Viruses: World of Microbiology and Immunology dictionary.
click on the image for a larger view) Figure 2. RSV virion structure and expression. Panel A shows a diagrammatic representation of a mature Rous sarcoma virus (RSV) virion. The legend at the right identifies individual proteins found in the mature virion. The outer membrane of the virion contains the transmembrane protein (TM), which is associated with the surface protein (SU). The matrix protein (MA) lies just under this outer membrane. The core of the virion is structurally delimited by the capsid protein (CA). Inside the capsid are two viral RNA genomes, shown partially covered with nucleocapsid protein (NC). The two genomic RNAs are hydrogen bonded near their 5 ends. The core also contains reverse transcriptase (RT), integrase (IN), and protease (PR). Panel B shows the relationship of the proviral DNA, the open reading frames, viral RNAs, and proteins of RSV. The LTRs of the provirus are shown as a series of three boxes (U3, R, and U5). The viral genome is divided into gag, pol, env, and ...
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In normal cultures, the transformation of monocytes into fibroblasts generally occurred when cells became packed together through some mechanical factors that prevented their free migration and determined their accumulation. Various modifications of the medium, the addition of dead tissue, and of trypsin or the products of trypsin digestion, failed to bring about the transformation. The inoculation af cultures of monocytes with filtered extract of Rous sarcoma frequently determined the appearance of fibroblasts. The first change undergone by the monocytes cultivated in vitro was a large increase in their size. Later, the giant monocytes became transformed into cells that did not differ essentially from those that grow from a fragment of adult connective tissue.. ...
Edited by John M. Coffin, Tufts University School of Medicine, Boston, MA (received for review February 24, 2004) ArticleFigures SIInfo gt;5 kDa in size are required. Furthermore, later steps of avian sarcoma and leukosis virus reverse tran
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Written by: Milan Duda & Petr Vykoukal Photo by: Vojtěch Vlk This Czech scientist has been leading a cancer research team in Copenhagen for thirteen years. We spoke to him about his teams recently published findings, which will have resounding effects on worldwide cancer research for years to come. Your discovery this
People of the Urus-Martan district call on the authorities to put an an end to the abuses and barbarous behaviour of Russian soldiers towards civilians, particularly the youths.
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Genus Alpharetrovirus; type species: Avian leukosis virus; others include Rous sarcoma virus ... Retroviruses that cause tumor growth include Rous sarcoma virus and Mouse mammary tumor virus. Cancer can be triggered by proto ... Walleye dermal sarcoma virus. *Genus Lentivirus; type species: Human immunodeficiency virus 1; others include Simian, Feline ... Rous sarcoma virus contains the src gene that triggers tumor formation. Later it was found that a similar gene in cells is ...
... end of the avian sarcoma virus genome". Nucleic Acids Research. 8 (13): 2967-84. doi:10.1093/nar/8.13.2967. PMC 324138. PMID ... terminus of the avian sarcoma virus genome". Proceedings of the National Academy of Sciences. 74 (4): 1473-7. Bibcode:1977PNAS ... Retroviruses such as human immunodeficiency virus (HIV) use this basic mechanism. As 5' and 3' LTRs are identical upon ... Valsamakis, A; Schek, N; Alwine, JC (1992). "Elements upstream of the AAUAAA within the human immunodeficiency virus ...
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the ... "Entrez Gene: CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like". Matsuki T, Pramatarova A, Howell BW (June 2008). " ...
"Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)". Berge EM, Doebele RC (February 2014). "Targeted ... Matsushime H, Wang LH, Shibuya M (August 1986). "Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus ... Matsushime H, Wang LH, Shibuya M (August 1986). "Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus ... sarcoma, cholangiocarcinomas and others. Crizotinib or other ROS1 inhibitors may be effective in other tumor histologies beyond ...
"Identification of a transformation-specific antigen induced by an avian sarcoma virus." Nature 269.5626 (1977): 346-8. Brugge, ... "The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins." Cell 25.2 (1981 ... "Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and ...
Species include the Rous sarcoma virus, avian leukosis virus, and avian myeloblastosis virus. Not all animals that can infect ... The tumor caused by the virus is usually in the form of lymphoma and leukemia. It occurs after a long and latent process. The ... Members can cause sarcomas, other tumors, and anaemia of wild and domestic birds and also affect rats. ...
"Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming ... "Detection and enumeration of transformation-defective strains of avian sarcoma virus with molecular hybridization". Virology. ... It belongs to a family of Src family kinases and is similar to the v-Src (viral Src) gene of Rous sarcoma virus. It includes an ... "Entrez Gene: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)". Wheeler DL, Iida M, Dunn EF (July 2009). " ...
v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains ... "Entrez Gene: CRK v-crk sarcoma virus CT10 oncogene homolog (avian)". Tetsuya Nakamoto; Ryuichi Sakai; Keiya Ozawa; Yoshio ... The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase ...
Rubin, H; Vogt PK (1962). "An avian leukosis virus associated with stocks of Rous sarcoma virus". Virology. 17: 184-94. doi: ... Maki, Y; Bos TJ; Davis C; Starbuck M; Vogt PK (1987). "Avian sarcoma virus 17 carries the jun oncogene". Proc Natl Acad Sci U S ... Toyoshima, K; Vogt PK (1969). "Temperature sensitive mutants of an avian sarcoma virus". Virology. 39 (4): 930-1. doi:10.1016/ ... Vogt, PK; Ishizaki R (1966). Burdette, WJ (ed.). "Criteria for the classification of avian tumor viruses". Viruses Inducing ...
... of avian sarcoma viruses is present in normal avian DNA". Nature. 260 (5547): 170-173. doi:10.1038/260170a0.. ... that gave rise to the v-src oncogene of Rous Sarcoma Virus, a cancer-causing virus first isolated from a chicken sarcoma by ... Jacks, T. and Varmus, H.E. Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science 230:1237, 1985. ... Bates, P; Young, JA; Varmus, HE (1993). "A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein ...
1978). "Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses". Cell. 13 (2): 371-379. ... She later worked with the research group of Harold E. Varmus on understanding how avian src protoncogenes worked. She ... at the time when the barriers to infection of bacterial cells by virus (bacteriophage) first became apparent, leading to the ...
Her initial focus used the avian sarcoma leukosis viruses (ASV) of chickens as a model system. With Bill McClements and others ... including the AIDS virus) replicate and insert their genetic material into the host genome." She was elected to the American ... the laboratory cloned part of the avian endogenous provirus ev-1 as well as its integration site; the results suggested ...
"Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product". Nature. 287 ( ... G. Steve Martin of the University of California, Berkeley demonstrated that SRC was indeed the gene of the virus that acted as ... The first confirmed oncogene was discovered in 1970 and was termed SRC (pronounced "sarc" as it is short for sarcoma). SRC was ...
"Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein". Cell. 15 ... Crise B, Rose JK (April 1992). "Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the ... Soula M, Fagard R, Fischer S (February 1992). "Interaction of human immunodeficiency virus glycoprotein 160 with CD4 in Jurkat ... on the syncytium formation induced by human immunodeficiency virus envelope glycoprotein". International Immunology. 4 (2): 233 ...
... of avian sarcoma viruses is present in normal avian DNA". Nature. 260 (5547): 170-173. Bibcode:1976Natur.260..170S. doi:10.1038 ... of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses". ... the chick was used to isolate the mumps virus for vaccine development and it is still used to culture some viruses and ... Human fascination with the chicken and its egg are so deeply rooted in history that it is hard to say exactly when avian ...
... of avian sarcoma viruses is present in normal avian DNA". Nature. 260 (5547): 170-173. Bibcode:1976Natur.260..170S. doi:10.1038 ... that gave rise to the v-src oncogene of Rous Sarcoma Virus, a cancer-causing virus first isolated from a chicken sarcoma by ... These changes can be produced by viruses, by radiation, or by exposure to some chemicals. Bishop is also a recipient of ...
"Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product". Nature. 287 ( ... The chicks developed sarcomas. The causative agent in the liquid was a virus, this is now called the Rous sarcoma virus (RSV). ... "Detection and enumeration of transformation-defective strains of avian sarcoma virus with molecular hybridization". Virology. ... v-Src is a gene found in Rous sarcoma virus (RSV) that encodes a tyrosine kinase that causes a type of cancer in chickens. The ...
"Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)".. ... "Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule". ... "Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule". ... sarcoma, cholangiocarcinomas and others.[24] Crizotinib or other ROS1 inhibitors may be effective in other tumor histologies ...
... terminus of the avian sarcoma virus genome". Proceedings of the National Academy of Sciences 74 (4): 1473-7. PMC 430805. PMID ... end of the avian sarcoma virus genome". Nucleic Acids Research 8 (13): 2967-84. PMC 324138. PMID 6253899. doi:10.1093/nar/8.13. ... Utilízanos os virus que insiren o seu material xenético no xenoma da célula hóspede. ... "Comparison of 5' and 3' long terminal repeat promoter function in human immunodeficiency virus". Journal of virology 68 (6): ...
UTR of Avian sarcoma, Rous sarcoma and Avian leukosis viruses (Alpharetroviruses and Avian type C retroviruses). dr1 is ... Aschoff JM, Foster D, Coffin JM (September 1999). "Point mutations in the avian sarcoma/leukosis virus 3' untranslated region ...
"Comparison of three recombinant murine leukemia viruses carrying the v-src oncogene of avian sarcoma virus: Differences in in ... As a specific case, a Gag-v-Onc fusion protein from the Rous sarcoma virus is useful in illustrating the dual role that the ... Rous sarcoma virus Fusion protein Fusion gene Fusion transcript Chimeric gene Bcr-abl fusion protein Oncovirus Retrovirus ... In the case of the murine leukemia viruses, a species of viruses capable of causing cancer in murines (mice), the viral life ...
ISBN 978-80-906605-1-9. KOREC, E., & HLOŽÁNEK, I. Susceptibility of the Minor line of inbred hens to the Rous sarcoma virus ... KOREC, E., & HLOŽÁNEK, I. Detection of avian leukosis virus group-specific antigens in feather pulp of chickens by Elisa. Folia ... His Master's thesis was an Analysis of Susceptibility and Resistance to Rous Sarcoma Virus in Inbred Line of Minor Poultry. ... KOREC, E., & HLOŽÁNEK, I. Analysis of the susceptibility of the Minor inbred chicken strain to Rous sarcoma virus infection. ...
The Env proteins of the Avian Sarcoma and Leukosis virus (ASLV) and the Murine Leukemia Virus (MLV) are both trimers of SU-TM ... Avian Sarcoma and Leukosis Viruses (ASLV) have ten subgroups (A through J). The envelope glycoprotein of subgroup A is called ... Balliet JW, Gendron K, Bates P (April 2000). "Mutational analysis of the subgroup A avian sarcoma and leukosis virus putative ... "Low pH is required for avian sarcoma and leukosis virus Env-dependent viral penetration into the cytosol and not for viral ...
1908: Vilhelm Ellerman and Olaf Bang, University of Copenhagen, first demonstrated that avian sarcoma leukosis virus could be ... hepatitis B and hepatitis C virus, Epstein-Barr virus, human T-lymphotropic virus, Kaposi's sarcoma-associated herpesvirus ( ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... RNA viruses[edit]. Not all oncoviruses are DNA viruses. Some RNA viruses have also been associated such as the hepatitis C ...
Ancient DNA Avian sarcoma leukosis virus (ASLV) Endogenous retrovirus ERV3 HERV-FRD Jaagsiekte sheep retrovirus (JSRV) Koala ... Murine leukemia virus (MLV), and xenotropic murine leukemia virus-related virus (XMRV) Paleovirology Polydnavirus Viral ... An endogenous viral element (EVE) is a DNA sequence derived from a virus, and present within the germline of a non-viral ... For most non-retroviral viruses, germline integration appears to be a rare, anomalous event, and the resulting EVEs are often ...
The AP-1 subunit Jun was identified as a novel oncoprotein of avian sarcoma virus, and Fos-associated p39 protein was ... Xie J, Pan H, Yoo S, Gao SJ (December 2005). "Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 ... "Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane ...
... horses Leucosis in sheep Feline leucosis Feline leukemia virus Avian leucosis and related diseases Avian sarcoma leukosis virus ... ISBN 0-7020-0718-8. H. Graham Purchase and L.N. Payne, Leukosis/sarcoma Group, in Diseases of poultry, ed. by M.S. Hofstad, ... Bovine leucosis Enzootic bovine leucosis, caused by bovine leukemia virus. Sporadic bovine leucosis Calf lymphosarcoma Leucosis ... "Bovine leukemia virus". The dictionary of virology (4th ed.). Amsterdam: Elsevier/Academic Press. pp. 61-62. ISBN 9780080920368 ...
Viruses portal Avian sarcoma leukosis virus (ASLV) Endogenous viral element ERV3 HERV-FRD Horizontal gene transfer Jaagsiekte ... Murine leukemia virus (MLV) and xenotropic murine leukemia virus-related virus (XMRV) Paleovirology Belshaw R, Pereira V, ... Yolken R (June 2004). "Viruses and schizophrenia: a focus on herpes simplex virus". Herpes. 11 (Suppl 2): 83A-88A. PMID ... "Reactivated Virus May Contribute to ALS". 2016-01-23. Karamitros T, Hurst T, Marchi E, Karamichali E, Georgopoulou U, Mentis A ...
... chain and bovine cyclic AMP-dependent protein kinase and the src gene product of Rous avian and Moloney murine sarcoma viruses ...
... such as Moloney murine leukemia virus (MoMLV), feline leukemia virus (FLV), and feline sarcoma virus (FESV). This family also ... Borisenko L (2003). "Avian endogenous retroviruses". Folia Biol. (Praha). 49 (5): 177-82. PMID 14680291. Stansell E, Tytler E, ... Matrix proteins are also components of beta-retroviruses such as Mason-Pfizer monkey virus (MPMV) and mouse mammary tumor virus ... "RNA dimerization defect in a Rous sarcoma virus matrix mutant". J. Virol. 74 (1): 164-72. doi:10.1128/jvi.74.1.164-172.2000. ...
Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ... The JC virus or John Cunningham virus is a type of human polyomavirus (formerly known as papovavirus). It was identified by ...
Genus Alpharetrovirus; type species: Avian leukosis virus; others include Rous sarcoma virus ... Retroviruses that cause tumor growth include Rous sarcoma virus and Mouse mammary tumor virus. Cancer can be triggered by proto ... Walleye dermal sarcoma virus. *Genus Lentivirus; type species: Human immunodeficiency virus 1; others include Simian, Feline ... Such viruses are either single stranded RNA (e.g. HIV) or double stranded DNA (e.g. Hepatitis B virus) viruses. ...
Talk:Avian reovirus. *Talk:Avian reovirus (version 2). *Talk:Avian sarcoma leukosis virus ... Pages in category "Low-importance virus articles". The following 200 pages are in this category, out of approximately 1,493 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:Low-importance_virus_articles&oldid=388350164" ...
Avian infectious laryngotracheitis. *Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis (blackhead disease) ...
Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ... DNA virus. HBV Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. ...
Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV ... V, Orthomyxoviridae: Influenza virus A/B/C/D *Influenza/Avian influenza. *V, Paramyxoviridae: Human parainfluenza viruses * ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. Human polyomavirus 2 Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis ...
Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV ... Further information: Influenza A virus subtype H7N9. Influenza A virus subtype H7N9 is a novel avian influenza virus first ... Avian influenza, known informally as avian flu or bird flu, is a variety of influenza caused by viruses adapted to birds.[1][2] ... Until H5N1, all known avian influenza viruses had a Glu at position 627, while all human influenza viruses had a Lys.[15]. HA ...
Kaposi's sarcoma-associated herpesvirus (Kaposi's sarcoma) · Epstein-Barr virus (Nasopharyngeal carcinoma, Burkitt's lymphoma, ... V, Orthomyxoviridae: Influenzavirus A/B/C (Influenza/Avian influenza). V, Paramyxovirus: Human parainfluenza viruses ( ... DNA virus: HBV (B). RNA virus: CBV · HAV (A) · HCV (C) · HDV (D) · HEV (E) · HGV (G) ... DNA virus: JCV (Progressive multifocal leukoencephalopathy). RNA virus:MeV (Subacute sclerosing panencephalitis) · LCV( ...
"Entrez Gene: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez? ... 2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): ...
Rous Sarcoma virus/ RSV, Mouse Mammary tumour virus/MMTV, Avian Myeloblastosis Virus/AMV আৰু Murine Leukaemia Virus/MuLV) পৰা ...
... hepatitis B virus, hepatitis C virus, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus and human T-lymphotropic ... Many serious diseases such as Ebola virus disease, AIDS, avian influenza, and SARS are caused by viruses. The relative ability ... I: dsDNA viruses. II: ssDNA viruses. III: dsRNA viruses. IV: (+)ssRNA viruses. V: (−)ssRNA viruses. VI: ssRNA-RT viruses. VII: ... A virus has either a DNA or an RNA genome and is called a DNA virus or an RNA virus, respectively. The vast majority of viruses ...
Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis (blackhead disease). *Botulism. *Campylobacteriosis. * ...
"A transmissible avian neoplasm. (Sarcoma of the common fowl) by Peyton Rous, M.D., Experimental Medicine for Sept. 1, 1910, vol ... Rous sarcoma virus).[2] Tahun 1976 Dr. John Michael Bishop dan Dr. Harold E. Varmus dari Universitas California San Francisco ... yang teraktivasi oleh avian erythroblastosis virus (AEV),[5] yang mengakibatkan leukemia pada ayam dengan menghambat ...
Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV ... "Carboxypeptidase D is an avian hepatitis B virus receptor" (PDF). Journal of Virology. 73 (10): 8696-8702. PMC 112890 . PMID ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ...
Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV ... HEV is classified into the family Hepeviridae, which is divided in two genera, Orthohepevirus (all mammalian and avian HEV ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. Human polyomavirus 2 Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis ...
... hepatitis B virus, hepatitis C virus, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus and human T-lymphotropic ... Many serious diseases such as Ebola virus disease, AIDS, avian influenza, and SARS are caused by viruses. The relative ability ... A virus has either a DNA or an RNA genome and is called a DNA virus or an RNA virus, respectively. The vast majority of viruses ... Quote: "Virus: virus (s.n. II), gen. sing. viri, nom. pl. vira, gen. pl. vīrorum (to be distinguished from virorum, of men)." ...
Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ... Human parainfluenza virus infection Human parainfluenza viruses (HPIV) Hymenolepiasis Hymenolepis nana and Hymenolepis diminuta ...
ssRNA-RT virus. Retroviridae. Alpharetrovirus. *Avian sarcoma leukosis virus. *Rous sarcoma virus ... Xenotropic Murine Leukemia Virus-Related Virus: Classification[citation needed] Xenotropic viruses (xenos Gr. foreign; tropos ... Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus which was first described in 2006 as an apparently novel ... "XMRV (Xenotropic Murine Leukemia Virus-related Virus) , CDC". www.cdc.gov. Retrieved 2018-04-17.. .mw-parser-output cite. ...
ssRNA-RT virus. Retroviridae. Alpharetrovirus. *Avian sarcoma leukosis virus. *Rous sarcoma virus ... dsDNA-RT viruses are the seventh group in the Baltimore virus classification. They are not considered DNA viruses (class I of ... Khan, Jawaid A.; Dijkstra, Jeanne (2002). Plant viruses as molecular pathogens. Psychology Press. pp. 317-. ISBN 978-1-56022- ... Retrieved from "https://en.wikipedia.org/w/index.php?title=DsDNA-RT_virus&oldid=748922731" ...
Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis (blackhead disease). *Botulism. *Campylobacteriosis. * ... Avian Biology Research, 1: 73-87 *^ Dixon, L.M., Duncan, I.J.H. and Mason, G.J., 2010. The effects of four types of enrichment ... G., (2010). Avian magnetoreception: Elaborate iron mineral containing dendrites in the upper beak seem to be a common feature ...
RNA virus, IV: Acute viral nasopharyngitis - Severe acute respiratory syndrome RNA virus, V: Influenza/Avian influenza - Human ... DNA virus: Hepatitis B - HPV - Kaposi's sarcoma-associated herpesvirus. RNA virus: Hepatitis C - HTLV ... DNA virus: HPV (Genital wart, Kanker sérviks). Virus RNA, retrovirus: HIV (AIDS, AIDS dementia complex) - Adult T-cell leukemia ... DNA virus, Herpesviridae: Herpes simplex - Chickenpox - Herpes zoster - KSHV DNA virus, liana: Poxviridae (Smallpox, Monkeypox ...
Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV Merkel-cell carcinoma. RNA virus. HCV ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... DNA virus. JCV Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV Lymphocytic ... Gastroenteritis viruses: A = rotavirus, B = adenovirus, C = norovirus and D = astrovirus. The virus particles are shown at the ...
"Avian sarcoma and leukosis virus-receptor interactions: from classical genetics to novel insights into virus-cell membrane ... Avian sarcoma leukosis virus is characterized by a wide range of tumors, the most common of which are lymphomas. Lymphoid ... Avian sarcoma leukosis virus (ASLV) is an endogenous retrovirus that infects and can lead to cancer in chickens; experimentally ... In 1961, Rous sarcoma virus (RSV), which is closely related to ASLV, was shown to contain RNA, and oncogenic viruses, such as ...
The mechanism of interference between an avian leukosis virus and Rous sarcoma virus. II. Early steps of infection by RSV of ...
... avian)), Authors: Shinya Tanaka. Published in: Atlas Genet Cytogenet Oncol Haematol. ... CRK (v-crk sarcoma virus CT10 oncogene homolog (avian)). Written. 2012-03. Shinya Tanaka. ... Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling. ... Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling. ...
... as the virus replicates and takes its first step toward virus formation and budding. ... Researchers used NMR to detail how the matrix domain of the Avian Sarcoma Virus Gag protein binds to certain phospholipids. ... Uncovering a key mechanism in assembly of Avian Sarcoma Virus, a 100-year-old oncogenic virus often used to study HIV-1. ... "Structural basis for targeting avian sarcoma virus Gag polyprotein to the plasma membrane for virus assembly," are Jiri Vlach, ...
V-crk sarcoma virus CT10 oncogene homolog (Avian), isoform CRA_aImported. ,p>Information which has been imported from another ... tr,Q5ND51,Q5ND51_MOUSE V-crk sarcoma virus CT10 oncogene homolog (Avian), isoform CRA_a OS=Mus musculus GN=Crk PE=2 SV=1 ... V-crk sarcoma virus CT10 oncogene-like proteinImported. ,p>Information which has been imported from another database using ...
A Nonviral, Virus Strain-specific Antigen Expressed on Rat Cells Transformed by Avian Sarcoma Virus. Edwin R. Phillips and ... A Nonviral, Virus Strain-specific Antigen Expressed on Rat Cells Transformed by Avian Sarcoma Virus ... A Nonviral, Virus Strain-specific Antigen Expressed on Rat Cells Transformed by Avian Sarcoma Virus ... A Nonviral, Virus Strain-specific Antigen Expressed on Rat Cells Transformed by Avian Sarcoma Virus ...
... contained the avian sarcoma virus genome. The number of cells needed for positive rescue experiments for avian sarcoma virus ... Avian Sarcoma Virus Transformed Hamster Cells made Resistant to Ethidium Bromide Message Subject (Your Name) has sent you a ... From avian sarcoma virus-transformed hamster cells already resistant to bromodeoxy-uridine (BrdU), ethidium bromide-resistant ... Hamster cells transformed with the Schmidt-Ruppin strain of avian sarcoma virus were selected for resistance to ethidium ...
Virus-Cell Interactions. Integration Targeting by Avian Sarcoma-Leukosis Virus and Human Immunodeficiency Virus in the Chicken ... Integration Targeting by Avian Sarcoma-Leukosis Virus and Human Immunodeficiency Virus in the Chicken Genome ... Integration Targeting by Avian Sarcoma-Leukosis Virus and Human Immunodeficiency Virus in the Chicken Genome ... Integration Targeting by Avian Sarcoma-Leukosis Virus and Human Immunodeficiency Virus in the Chicken Genome ...
Extensive in vitro transcription of rous sarcoma virus RNA by avian myeloblastosis virus DNA polymerase and concurrent ... Extensive in vitro transcription of rous sarcoma virus RNA by avian myeloblastosis virus DNA polymerase and concurrent ... Extensive in vitro transcription of rous sarcoma virus RNA by avian myeloblastosis virus DNA polymerase and concurrent ... Extensive in vitro transcription of rous sarcoma virus RNA by avian myeloblastosis virus DNA polymerase and concurrent ...
... ... Uncovering a key mechanism in assembly of Avian Sarcoma Virus, a 100-year-old oncogenic virus often used to study HIV-1. by ... Citation: Uncovering a key mechanism in assembly of Avian Sarcoma Virus, a 100-year-old oncogenic virus often used to study HIV ... Structural basis for targeting avian sarcoma virus Gag polyprotein to the plasma membrane for virus assembly, Journal of ...
... of avian sarcoma virus integrase (ASV-IN) dimer. ... of avian sarcoma virus integrase (ASV-IN) dimer. Starting model ... Computer Aided Study of Ligand Binding to with Catalytic Domain of Avian Sarcoma Virus Integrase. We report here 500 pico ...
... of a 36,000-dalton substrate for tyrosine phosphorylation in chicken embryo fibroblasts transformed by avian sarcoma viruses. K ... of a 36,000-dalton substrate for tyrosine phosphorylation in chicken embryo fibroblasts transformed by avian sarcoma viruses.. ... of 36,000 daltons becomes phosphorylated at tyrosine in chicken embryo fibroblasts transformed with avian sarcoma viruses. We ... The same pattern of staining was found in both uninfected and virus-transformed cells. Pretreatment of cells with nonionic ...
Receptor specificity in avian sarcoma and leukosis viruses (ASLV) maps to the central region of the envelope surface protein, ... of the ASLV envelope sequences revealed a cluster of basic residues within hr2 that is unique to the subgroup A viruses, ... Receptor-induced conformational changes in the subgroup A avian leukosis and sarcoma virus envelope glycoprotein.. *J M Gilbert ... Receptor specificity in avian sarcoma and leukosis viruses (ASLV) maps to the central region of the envelope surface protein, ...
Actually, endogenous avian sarcoma and leukosis virus (enASLV) sequences are variable in the Galliformes birds, and geese have ... Reply to commentary by D. Elleder and J. Hejnar on the article "Avian sarcoma and leukosis virus gag gene in the Anser anser ... Actually, endogenous avian sarcoma and leukosis virus (enASLV) sequences are variable in the Galliformes birds, and geese have ... Actually, endogenous avian sarcoma and leukosis virus (enASLV) sequences are variable in the Galliformes birds, and geese have ...
... or combined irradiation and BCNU were studied in the avian sarrcoma virus (ASV)-induced glioma model in rats. Whole-head ... An in vivo study using the avian sarcoma virus-induced glioma model.. *. Paul Steinbok, M. Stephen Mahaley, +4 authors Darell D ... An in vivo study using the avian sarcoma virus-induced glioma model.}, author={Paul Steinbok and M. Stephen Mahaley and ... The therapeutic effects of irradiation, BCNU, or combined irradiation and BCNU were studied in the avian sarrcoma virus (ASV)- ...
Lentiviral vectors pseudotyped with avian sarcoma/leukosis virus subgroup A or B envelope proteins and bearing bi-functional ... Our results indicate that the avian sarcoma/leukosis virus bridge strategy provides a reliable approach for cell-specific ... An alternative approach involved soluble avian sarcoma/leukosis virus receptors fused to cell-specific ligands including stem ... encoding erythropoietin or stem cell factor fused to the soluble extracellular domains of the avian sarcoma/leukosis virus ...
... of a novel avian leukosis virus (ALV), strain HPRS-103, and representative RSV pseudotypes of subgroups A to F, have been ... The host range pattern of RSV(HPRS-103) differs from those of viruses of subgroups A to G and I, and provides support for ... determined in embryo fibroblasts from 12 avian species. Domestic fowl, red jungle fowl, Sonnerat's jungle fowl and turkey ... The host ranges of the Rous sarcoma virus (RSV) pseudotype RSV(HPRS-103) ...
Biologically active molecular clones of avian sarcoma virus 17 (ASV 17) contain a replication-defective proviral genome of 3.5 ...
We describe 12 nonconditional mutants of avian sarcoma virus. Eleven were replication defective and one appeared to retain wild ... Alterations in the genomes of avian sarcoma viruses. Virology, 117 (2). pp. 456-474. ISSN 0042-6822 ... Defective Viruses/isolation & purification; Genetic Complementation Test; Helper Viruses/metabolism; Mutation; Quail; RNA, ...
Avian sarcoma leukosis virus ~~~ Title: What is Avian sarcoma leukosis virus?, Explain Avian sarcoma leukosis virus Created on ... What is Avian sarcoma leukosis virus?, Explain Avian sarcoma leukosis virus. by admin · April 14, 2019. ...
Four previously uncharacterized avian sarcoma viruses were screened and two of these, RPL30 and CTIO, were found to encode ... Four previously uncharacterized avian sarcoma viruses were screened and two of these, RPL30 and CTIO, were found to encode ... Molecular Cloning of Avian Sarcoma Virus CT10 and Characterization of its Protein Product ... Mayer, Bruce J., "Molecular Cloning of Avian Sarcoma Virus CT10 and Characterization of its Protein Product" (1989). Student ...
Genus Alpharetrovirus; type species: Avian leukosis virus; others include Rous sarcoma virus ... Retroviruses that cause tumor growth include Rous sarcoma virus and Mouse mammary tumor virus. Cancer can be triggered by proto ... Walleye dermal sarcoma virus. *Genus Lentivirus; type species: Human immunodeficiency virus 1; others include Simian, Feline ... Such viruses are either single stranded RNA (e.g. HIV) or double stranded DNA (e.g. Hepatitis B virus) viruses. ...
Genus Alpharetrovirus; type species: Avian leukosis virus; others include Rous sarcoma virus ... Retroviruses that cause tumor growth include Rous sarcoma virus and Mouse mammary tumor virus. Cancer can be triggered by proto ... Walleye dermal sarcoma virus. *Genus Lentivirus; type species: Human immunodeficiency virus 1; others include Simian, Feline ... Rous sarcoma virus contains the src gene that triggers tumor formation. Later it was found that a similar gene in cells is ...
It is a visual image, in molecular detail, of their journal article inside that looks at avian sarcoma virus, or ASV. ... Uncovering a key mechanism in assembly of Avian Sarcoma Virus, a relative of HIV-1. By Sheela on December 19, 2018 ... as the virus replicates and takes its first step toward virus formation and budding. ... It belongs to the retroviridae family and is closely related to HIV, the virus that causes AIDS. ASV is widely used as a model ...
Proper processing of avian sarcoma/leukosis virus capsid proteins is required for infectivity. / Xiang, Y.; Thorick, R.; Vana, ... Xiang Y, Thorick R, Vana ML, Craven R, Leis J. Proper processing of avian sarcoma/leukosis virus capsid proteins is required ... The formation of the mature carboxyl terminus of CA in avian sarcoma/leukemia virus is the result of a sequence of cleavage ... Xiang, Y., Thorick, R., Vana, M. L., Craven, R., & Leis, J. (2001). Proper processing of avian sarcoma/leukosis virus capsid ...
Herpes Viruses VIII. Adenoviruses IX. Papova Viruses X. Myxoviruses XL Avian Sarcomas and Lymphomas XII. Picorna Viruses XIII. ... Isolation of Viruses in Tissue Culture III. Identification of Viruses IV. Titration of Viruses. V. Replication of Viruses VI. ... Production of Virus Vaccines VIII. Transformation of Cells by Viruses IX. Virus Studies in Organ Cultures References 5. ... Miscellaneous Viruses XV. Apologia and Epilogue References 4. Cell, Tissue and Organ Cultures in Virus Research. I. ...
Asp-Ser-Gly is found in avian sarcoma leukaemia viruses (ASLV) and Asp-Thr-Gly in mammalian oncoretroviruses. We have mutated ... However, this mutation reduced the production of reverse transcriptase-containing particles and infectious virus following ... as well as synthetic peptides homologous to ASLV and human immunodeficiency virus type 1 cleavage sites. Bacterially produced ... Point mutation in avian sarcoma leukaemia virus protease which increases its activity but impairs infectious virus production * ...
Rous sarcoma virus definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ... An avian retrovirus that causes Rous sarcoma.. QUIZZES. THINK YOUVE GOT A HANDLE ON THIS US STATE NICKNAME QUIZ?. Did you ever ... Words nearby Rous sarcoma virus. rouse, rouseabout, rouser, rousing, Rous sarcoma, Rous sarcoma virus, Rousseau, Rousseauism, ... He became delirious, his heartbeat grew ragged, his blood teemed with the virus, and his lungs, liver and kidneys began to fail ...
  • In 1961, Rous sarcoma virus (RSV), which is closely related to ASLV, was shown to contain RNA, and oncogenic viruses, such as RSV and ASLV, were termed RNA tumor viruses. (wikipedia.org)
  • The mechanism of interference between an avian leukosis virus and Rous sarcoma virus. (nih.gov)
  • Extensive in vitro transcription of rous sarcoma virus RNA by avian myeloblastosis virus DNA polymerase and concurrent activation of the associated RNase H. (asm.org)
  • Conditions are described that promote the efficient reverse transcription of most of Rous sarcoma virus (RSV) RNA sequences by avian myeloblastosis virus DNA polymerase in vitro. (asm.org)
  • Kinetic analysis of binding interaction between the subgroup A Rous sarcoma virus glycoprotein SU and its cognate receptor Tva: calcium is not required for ligand binding. (semanticscholar.org)
  • A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor. (semanticscholar.org)
  • The host ranges of the Rous sarcoma virus (RSV) pseudotype RSV(HPRS-103) of a novel avian leukosis virus (ALV), strain HPRS-103, and representative RSV pseudotypes of subgroups A to F, have been determined in embryo fibroblasts from 12 avian species. (microbiologyresearch.org)
  • Rous Sarcoma Virus -Leslie Parent 29. (indigo.ca)
  • He is currently focusing his research on the oncogenic transformation of cells by Rous Sarcoma Virus (RSV). (utdallas.edu)
  • Rous sarcoma virus (RSV) causes cancer in chickens and other avian species. (utdallas.edu)
  • The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins. (harvard.edu)
  • Rous sarcoma virus (RSV) serves as the model for much of this work and will frequently be referred to for comparative purposes, as will the mammalian defective transforming viruses. (springer.com)
  • The discovery of Rous sarcoma virus, which was reported by Peyton Rous in the Journal of Experimental Medicine 100 years ago, opened the field of tumor virology. (rupress.org)
  • This year marks the centenary of the publication in the JEM ( Rous, 1911 ) of one of the twentieth century's most seminal discoveries in medical research, namely, the filterable agent that became known as Rous sarcoma virus (RSV). (rupress.org)
  • Avian subgroup A rous sarcoma virus receptor (1 copy of LDLRA). (ebi.ac.uk)
  • Rous sarcoma virus - a sarcoma-producing virus of the avian leukosis-sarcoma complex identified by Rous in 1911. (thefreedictionary.com)
  • It is caused by the Rous sarcoma virus, a retrovirus, which occurs in several serotypes and is transferable to rabbits, mice, rats, hamsters and primates as well as chickens. (thefreedictionary.com)
  • src-Specific immune regression of Rous sarcoma virus-induced tumors. (thefreedictionary.com)
  • The importance of MHC for Rous sarcoma virus and Marek's disease virus--some Payneful considerations. (thefreedictionary.com)
  • Rous sarcoma virus (RSV) (/raʊs/) is a retrovirus and is the first oncovirus to have been described. (wikipedia.org)
  • A conserved secondary structure element has been identified within the 3'UTR and is known as the Rous Sarcoma Virus Stability Element (RSE). (wikipedia.org)
  • The RSE element was first identified in the genome of the Rous Sarcoma Virus but appears to be widely conserved across the avian retrovirus family. (wikipedia.org)
  • The discoveries of Rous sarcoma virus, reverse transcriptase, and the Src oncogene were awarded Nobel Prizes in medicine and physiology in 1966, 1975, and 1989, respectively (Weiss and Vogt, 2011). (deepdyve.com)
  • It belongs to a family of Src family kinases and is similar to the v-Src (viral Src) gene of Rous sarcoma virus. (wikipedia.org)
  • Eventually this normal gene mutated into an abnormally functioning oncogene within the Rous sarcoma virus. (wikipedia.org)
  • A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. (umassmed.edu)
  • Crk has been reported to bind to NS1 protein of influenza virus type H5N1, CagA protein of Helicobacter pylori, and also known to regulate the infection of Pseudomonas aeruginosa and Shigella flexneri. (atlasgeneticsoncology.org)
  • These phospholipids are vital for Gag protein binding to the plasma membrane of a cell, as the virus replicates and takes its first step toward virus formation and budding. (newswise.com)
  • The work led by Saad, associate professor of microbiology at UAB, and a companion paper , led by Carol Carter, Ph.D., professor of molecular genetics and microbiology at Stony Brook University, examined how the ASV Gag protein is targeted to the plasma membrane of the host cell to initiate virus assembly. (newswise.com)
  • The companion paper in the Journal of Biological Chemistry is titled "The matrix domain of the Gag protein from avian sarcoma virus contains a PI(4,5)P2-binding site that targets Gag to the cell periphery. (newswise.com)
  • A cellular protein of 36,000 daltons becomes phosphorylated at tyrosine in chicken embryo fibroblasts transformed with avian sarcoma viruses. (rupress.org)
  • We have used cellular fractionation and immunofluorescence to locate the 36-kdalton protein in virus-transformed and uninfected chicken fibroblasts. (rupress.org)
  • Receptor specificity in avian sarcoma and leukosis viruses (ASLV) maps to the central region of the envelope surface protein, SU. (semanticscholar.org)
  • In one of the strategies, vector particles bearing a membrane-bound stem cell factor sequence plus a separate fusion protein based either on Sindbis virus strain TR339 glycoproteins or the vesicular stomatitis virus G glycoprotein were used to selectively transduce cells expressing the corresponding stem cell factor receptor (c-kit). (biomedcentral.com)
  • Transduction of erythropoietin receptor-expressing cells mediated by bi-functional bridge proteins was found to be dependent on the dose, the correct subgroup-specific virus receptor and the correct envelope protein. (biomedcentral.com)
  • Such targeting approaches have involved engineered versions of the Sindbis virus E2 glycoprotein bearing either a Staphylococcus aureus protein A domain [ 4 - 14 ] or single chain antibody fragments fused in-frame to the E2 glycoprotein coding region [ 15 ], allowing antibody-mediated cell targeting in the presence of the Sindbis virus E1 fusion protein. (biomedcentral.com)
  • Mayer, Bruce J., "Molecular Cloning of Avian Sarcoma Virus CT10 and Characterization of its Protein Product" (1989). (rockefeller.edu)
  • In most viruses, DNA is transcribed into RNA, and then RNA is translated into protein . (wikipedia.org)
  • Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. (nature.com)
  • Mechanistically, high BCL2 family member and CDK4, but low P53 and INK4A protein expression synergized in Ewing-like sarcoma development. (nature.com)
  • The viral gene responsible for the oncogenicity (cancer-causing ability) of this virus is called the src gene, and it encodes a protein termed pp60v-src. (utdallas.edu)
  • The ASLV TM glycoprotein has been proposed to adopt a structure similar to that of the Ebola virus GP2 protein: each contains an internal fusion peptide flanked by cysteine residues predicted to be in a disulfide bond. (mendeley.com)
  • A signal transducing adaptor protein that is encoded by the crk ONCOGENE from TYPE C AVIAN RETROVIRUSES. (curehunter.com)
  • Now researchers from the Institut de Virologie Molculaire et Structurale (IVMS) and the Outstation of the European Molecular Biology Laboratory (EMBL) in Grenoble have obtained a detailed structural picture of a protein that allows the rabies virus to withstand the human immune response and survive and replicate in our cells. (bio-medicine.org)
  • The protein ensures that on its way through the cell the virus RNA is not destroyed by the immune response of the host. (bio-medicine.org)
  • Data indicate the role of tyrosine phosphorylation in regulating modular domain utilization in v-crk sarcoma virus CT10 oncogene homolog (avian ) protein ( Crk ). (antibodies-online.com)
  • As DNA viruses, which replicate in the nucleus of infected cells, the bipartite begomoviruses (Geminiviridae family) encode the nuclear shuttle protein (NSP) to facilitate the translocation of viral D. (bioportfolio.com)
  • pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. (wikipedia.org)
  • Hence, it is an enveloped virus with a condensed, central core, and has barely visible envelope spikes, or proteins. (wikipedia.org)
  • Despite great similarities in their Gag proteins that initiate virus assembly, retroviruses have distinct mechanisms for assembly that are incompletely understood. (newswise.com)
  • An alternative approach involved soluble avian sarcoma/leukosis virus receptors fused to cell-specific ligands including stem cell factor and erythropoietin for targeting lentiviral vectors pseudotyped with avian sarcoma/leukosis virus envelope proteins to cells that express the corresponding receptors. (biomedcentral.com)
  • The titers of unconcentrated vector particles bearing Sindbis virus strain TR339 or vesicular stomatitis virus G fusion proteins plus stem cell factor in the context of c-kit expressing cells were up to 3.2 × 10 5 transducing units per ml while vector particles lacking the stem cell factor ligand displayed titers that were approximately 80 fold lower. (biomedcentral.com)
  • Lentiviral vectors pseudotyped with avian sarcoma/leukosis virus subgroup A or B envelope proteins and bearing bi-functional bridge proteins encoding erythropoietin or stem cell factor fused to the soluble extracellular domains of the avian sarcoma/leukosis virus subgroup A or B receptors resulted in efficient transduction of erythropoietin receptor or c-kit-expressing cells. (biomedcentral.com)
  • The background levels were lower compared to alternative strategies involving Sindbis virus strain TR339 or vesicular stomatitis virus fusion proteins. (biomedcentral.com)
  • The host cell then treats the viral DNA as part of its own genome , transcribing and translating the viral genes along with the cell's own genes, producing the proteins required to assemble new copies of the virus. (wikipedia.org)
  • To study the importance of each of the three CA proteins, we introduced amino acid substitutions into each CA cleavage junction and studied their effects on CA processing as well as virus assembly and infectivity. (uthscsa.edu)
  • These results support the idea that infectivity of the virus is closely linked to proper processing of the carboxyl terminus to form two mature CA proteins. (uthscsa.edu)
  • Changes in the synthesis and phosphorylation of cellular proteins in chick fibroblasts transformed by two avian sarcoma viruses. (harvard.edu)
  • Antibody to virion structural proteins in mammals bearing avian sarcoma virus-induced tumors. (harvard.edu)
  • Not long after oncogenes were discovered, DNA tumor viruses were shown to encode proteins that sequester cell proteins and induce their loss-of-function for controlling the cell cycle. (rupress.org)
  • Silva RF, Baluda MA (to be published) Avian myeloblastosis virus proteins in leukemic chicken myeloblasts. (springer.com)
  • Gag proteins are necessary for virion assembly and mature virus infection of the host cell. (wikipedia.org)
  • During HIV-1 assembly, precursor Gag (PrGag) proteins are delivered to plasma membrane (PM) assembly sites, where they are triggered to oligomerize and bud from cells as immature virus particles. (frontiersin.org)
  • Triggering of oligomerization, budding, and virus particle release results when NC domains on adjacent PrGag proteins bind to viral RNA, leading to capsid (CA) domain oligomerization. (frontiersin.org)
  • One of these roles involves the incorporation of the viral envelope (Env) proteins into virus particles. (frontiersin.org)
  • It is one of the few proteins that the virus brings into the host cell and it wraps around the RNA like a protection shield. (bio-medicine.org)
  • In order to replicate they must take control of a host cell and order its DNA to produce proteins and all that is necessary for the multiplication of the virus. (canceractive.com)
  • As with all retroviruses, the virus is transcribed from RNA to DNA, instead of DNA to RNA as in normal cellular replication. (wikipedia.org)
  • We have analyzed the placement of sites of integration of avian sarcoma-leukosis virus (ASLV) and human immunodeficiency virus (HIV) DNA in the draft chicken genome sequence, with the goals of assessing species-specific effects on integration and allowing comparison to the distribution of chicken endogenous retroviruses (ERVs). (asm.org)
  • In chickens, however, there is a large class of endogenous retroviruses, members of the ERVK group, that are related to the replication-competent avian sarcoma-leukosis viruses (ASLV). (asm.org)
  • However, retroviruses function differently, as their RNA is reverse-transcribed into DNA, which is integrated into the host cell's genome (when it becomes a provirus ), and then undergoes the usual transcription and translational processes to express the genes carried by the virus. (wikipedia.org)
  • Avian and Murine Retroviruses -Karen Beemon & Naomi Rosenberg28. (indigo.ca)
  • The entry process of the avian sarcoma and leukosis virus (ASLV) family of retroviruses requires first a specific interaction between the viral surface (SU) glycoproteins and a receptor on the cell surface at a neutral pH, triggering conformational changes in the viral SU and transmembrane (TM) glycoproteins, followed by exposure to low pH to complete fusion. (mendeley.com)
  • Lymphomagenesis occurs because of the production of endogenous retroviruses ( 2 ) and the intrathymic injection of recombinant (thymotropic) murine leukemia virus accelerates the appearance of tumors ( 3 ). (jimmunol.org)
  • He also showed how retroviruses such as the avian sarcoma virus reproduce and integrate with the genetic material of the infected cell. (laskerfoundation.org)
  • Arthur D. Levinson, Ph.D., Chairman of Genentech, has replaced Steve Jobs as Chairman of the Board of Apple, Inc . During his scientific career, Levinson did research on different viruses, including adenovirus, retroviruses, and hepatitis B virus. (virology.ws)
  • All resistant cell lines, including the doubly resistant cell line, contained the avian sarcoma virus genome. (biologists.org)
  • The number of cells needed for positive rescue experiments for avian sarcoma virus genome by cell fusion with permissive chicken embryo cells was the same as with the original cell lines. (biologists.org)
  • Reply to commentary by D. Elleder and J. Hejnar on the article "Avian sarcoma and leukosis virus gag gene in the Anser anser domesticus genome" published in Genetics and Molecular Research 14 (4): 14379-14386 to the letter published in Genet. (geneticsmr.com)
  • Biologically active molecular clones of avian sarcoma virus 17 (ASV 17) contain a replication-defective proviral genome of 3.5 kilobases (kb). (scripps.edu)
  • A retrovirus is a type of RNA virus that inserts a copy of its genome into the DNA of a host cell that it invades, thus changing the genome of that cell. (wikipedia.org)
  • Once inside the host cell's cytoplasm , the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backwards). (wikipedia.org)
  • Souza LM, Baluda MA (to be published) Identification of the avian myeloblastosis virus genome. (springer.com)
  • Souza LM, Komaromy MC, Baluda MA (1980) Identification of a proviral genome associated with avian myeloblastic leukemia. (springer.com)
  • Souza LM, Strommer JN, Hillyard RL, Komaromy MC, Baluda MA (to be published b) Cellular sequences are present in the presumptive avian myeloblastosis virus genome. (springer.com)
  • Souza L.M., Bergmann D.G., Baluda M.A. (1981) Identification of the Avian Myeloblastosis Virus Genome. (springer.com)
  • RSV is a class VI enveloped virus with a positive sense RNA genome having a DNA intermediate. (wikipedia.org)
  • Fusion occurs when the virus fuses together with the target cell membrane and releases its genome into the cell. (wikipedia.org)
  • Transcription of the viral genome in cell lines transformed by simian virus 40. (uni-trier.de)
  • Membrane association of a 36,000-dalton substrate for tyrosine phosphorylation in chicken embryo fibroblasts transformed by avian sarcoma viruses. (rupress.org)
  • Linear viral DNA isolated from the cytoplasm of helper virus (MAV-1 or MAV-2) infected chicken embryonic fibroblasts (CEF) has a mass of 5.3 million daltons (md) (Bergmann et al. (springer.com)
  • Sarcoma in chickens has been studied since the early 1900s when Ellerman and Bang demonstrated that erythroleukemia can be transmitted between chickens by cell-free tissue filtrates, and in 1911 when (Francis) Peyton Rous proved that sarcoma can be transmitted through cell free extracts of solid chicken tumors. (wikipedia.org)
  • B-haplotype influence on Marek's disease, Rous sarcoma , and lymphoid leukosis virus-induced tumors in chickens. (thefreedictionary.com)
  • Rous sarcoma regression in chickens resistant or susceptible to Marek's disease. (thefreedictionary.com)
  • He delivered the first successful antisense attack against a virus by adding small pieces of synthesized antisense DNA to a cell culture to block the RNA of the virus causing Rous sarcoma , a cancer of chickens. (thefreedictionary.com)
  • In addition to neoplasias caused in chickens by helper viruses of the avian myeloblastosis virus (AMV) complex, acute myeloblastic leukemia is induced by a defective leukemogenic component. (springer.com)
  • It causes sarcoma in chickens. (wikipedia.org)
  • Meng, Fanfeng;Li, Qiuchen;Zhang, Yubiao;Cui, Zhizhong;Chang, Shuang;Zhao, Peng 2018-07-11 00:00:00 Abstract There was an outbreak of hemangioma associated with avian leukosis virus subgroup J (ALV-J) between 2006 and 2010 in China in commercial layer chickens. (deepdyve.com)
  • Virus Isolation Blood samples were collected aseptically from the infected Hy-Line brown layer chickens with suspected hemangioma, and all blood samples were centrifuged at 2,000 revolutions per minute for 2 min at 4°C to obtain plasma for virus isolation. (deepdyve.com)
  • Role of basic residues in the subgroup-determining region of the subgroup A avian sarcoma and leukosis virus envelope in receptor binding and infection. (semanticscholar.org)
  • Antigenic variants of J subgroup avian leukosis virus: sequence analysis reveals multiple changes in the env gene. (semanticscholar.org)
  • The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily. (semanticscholar.org)
  • Evolutionary pressure of a receptor competitor selects different subgroup a avian leukosis virus escape variants with altered receptor interactions. (semanticscholar.org)
  • Analysis of the subgroup A avian sarcoma and leukosis virus receptor: the 40-residue, cysteine-rich, low-density lipoprotein receptor repeat motif of Tva is sufficient to mediate viral entry. (semanticscholar.org)
  • Identification and characterization of the viral interaction determinant of the subgroup A avian leukosis virus receptor. (semanticscholar.org)
  • Receptor-induced conformational changes in the subgroup A avian leukosis and sarcoma virus envelope glycoprotein. (semanticscholar.org)
  • A soluble form of a receptor for subgroup A avian leukosis and sarcoma viruses (ALSV-A) blocks infection and binds directly to ALSV-A. (semanticscholar.org)
  • The receptor for the subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not to subgroup C envelope glycoprotein. (semanticscholar.org)
  • The host range pattern of RSV(HPRS-103) differs from those of viruses of subgroups A to G and I, and provides support for placing the HPRS-103 strain of ALV in a new envelope subgroup, designated J. (microbiologyresearch.org)
  • The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus. (nih.gov)
  • The cellular receptor for subgroup A avian leukosis and sarcoma virus (ALSV-A) is Tva, which contains a motif related to repeats in the low density lipoprotein receptor (LDLR) ligand binding repeat (LBr) and which is necessary for viral entry. (nih.gov)
  • Avian leukosis virus subgroup J was identified by an immunofluorescence assay with monoclonal antibody JE9, whereas Marek's disease virus or reticuloendotheliosis virus was not detected. (deepdyve.com)
  • 2016). Subgroup J avian leukosis virus (ALV-J) was first isolated and identified in 1988 in the United Kingdom (Payne et al. (deepdyve.com)
  • Investigation of TSA for immunological relationship to viral structural antigens and the src gene product indicated that the TSA is distinct from any of these and more probably derives from a virus-directed alteration in a host molecule. (aacrjournals.org)
  • If any bias of content is introduced, this will be towards a more detailed coverage of the author's own area of interest, the gene products of the defective sarcoma viruses. (springer.com)
  • For example, the myc gene was first identified in an avian myelocytoma virus and the ras gene was first identified in rat sarcoma virus long before they became associated with human malignancies. (rupress.org)
  • Following his isolation of the T-cell growth factor, which stimulates T lymphocytes to divide and proliferate to fight an infection, Dr. Gallo undertook detailed research on T-cell leukemias-leading ultimately to a virus which activated inappropriately the gene coding for T-cell growth factor. (laskerfoundation.org)
  • From these tumors he isolated virus which now contained the complete src gene sequence. (laskerfoundation.org)
  • There he published on the transforming gene of the retrovirus avian sarcoma virus. (virology.ws)
  • It is believed that at one point an ancestral virus mistakenly incorporated the c-Src gene of its cellular host. (wikipedia.org)
  • Protease is expressed differently in different viruses. (wikipedia.org)
  • It is cleaved by virus encoded protease, releasing products found in the infectious virion. (wikipedia.org)
  • Under optimal conditions of reverse transcription, we find now that the RNase H associated with the avian myeloblastosis virus DNA polymerase is active in degrading the RNA moiety of the RNA-DNA hybrids synthesized. (asm.org)
  • Bergmann DG, Souza LM, Baluda MA (1980) Characterization of the avian myeloblastosis associated virus DNA intermediates. (springer.com)
  • [ 27 ] The proto-oncogene C-Myb (v-myb myeloblastosis viral oncogene homolog [avian], also known as Myb ) is a critical target of miR-150. (medscape.com)
  • Structural requirements for binding of bovine tRNATrp with avian myeloblastosis virus DNA polymerase. (uni-trier.de)
  • Viral form I DNA of 5 to 7 × 10 6 daltons is infectious in chick embryo cells, resulting in production of avian sarcoma virus and transformation-defective virus, whereas viral form I DNA of 2 to 4 × 10 6 daltons is not infectious in similar tests and is presumably defective. (elsevier.com)
  • BK virus and Transformation - Hans Hirsch17. (indigo.ca)
  • JC virus and Transformation -Kamel Khalili 18. (indigo.ca)
  • During the 1960s, two findings emerged: replication-competent isolated viruses were related to RSV, but were non-transforming, and an isolated replication-defective strain of RSV was transformation-competent. (wikipedia.org)
  • Avian sarcoma leukosis virus is characterized by a wide range of tumors, the most common of which are lymphomas. (wikipedia.org)
  • Connective tissue tumors, affecting primarily fowl, that are usually caused by avian sarcoma viruses. (harvard.edu)
  • Crk was originally isolated as avian retrovirus (CT10, chicken tumor No. 10) encoding oncoprotein as v-Crk (viral Crk, CT10 regulator of kinase). (atlasgeneticsoncology.org)
  • On www.antibodies-online.com are 13 V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK) ELISA Kits from 8 different suppliers available. (antibodies-online.com)
  • ASLV is a Group VI virus of the family Retroviridae. (wikipedia.org)
  • Asp-Ser-Gly is found in avian sarcoma leukaemia viruses (ASLV) and Asp-Thr-Gly in mammalian oncoretroviruses. (microbiologyresearch.org)
  • Both wild-type and mutated PRs correctly cleaved viral precursors expressed in bacterial cells, as well as synthetic peptides homologous to ASLV and human immunodeficiency virus type 1 cleavage sites. (microbiologyresearch.org)
  • Five of six rat sarcomas, induced by the Schmidt-Ruppin (SR) strain of avian tumor virus, expressed a M r 60,000 tumor cell surface antigen (TSA), immunoprecipitable from non-ionic detergent extracts. (aacrjournals.org)
  • Hamster cells transformed with the Schmidt-Ruppin strain of avian sarcoma virus were selected for resistance to ethidium bromide (EB). (biologists.org)
  • Actually, endogenous avian sarcoma and leukosis virus (enASLV) sequences are variable in the Galliformes birds, and geese have split with chicken for a long time. (geneticsmr.com)
  • Rous's most famous discovery was finding that a sarcoma in the domestic fowl was transmissible to other fowl by a tumor extract that he had passed through a filter too fine to contain chicken cells or bacteria. (rupress.org)
  • Chicken viruses are killed when the chicken is cooked, but can you 'catch' it from raw meat? (canceractive.com)
  • and reiculoendotheliosis virus (REV). Each can kill a chicken within a week of infection. (canceractive.com)
  • A detailed understanding of retroviral cell entry may lead to the discovery of ways in which to block the viruses from entering cells. (wikipedia.org)
  • The subgroups evolved to utilize difference cellular receptors to gain entry into avian cells due to the host developing resistance to viral entry. (wikipedia.org)
  • Expression of the antigen was exclusive to rat cells transformed by the SR virus strain. (aacrjournals.org)
  • The five TSA-positive SR-transformed rat cell lines tested were apparently of fibroblastic origin, but cultured rat cerebral endothelial cells (RCE-T1), transformed by SR virus, showed no expression of TSA. (aacrjournals.org)
  • From avian sarcoma virus-transformed hamster cells already resistant to bromodeoxy-uridine (BrdU), ethidium bromide-resistant cells which were able to grow in 10 µg/ml EB were also prepared. (biologists.org)
  • The single EB-resistant cell lines contained R-type virus-like particles, while in BrdU-resistant and doubly resistant cells the R-type particles were absent. (biologists.org)
  • Studies of several thousand sites of human immunodeficiency virus (HIV) integration in human cells indicated that transcription units (TUs) are favored for integration, and comparison to transcriptional profiles from target cells indicates that active TUs are particularly favored ( 19 , 26 , 31 ). (asm.org)
  • The same pattern of staining was found in both uninfected and virus-transformed cells. (rupress.org)
  • One drawback of these approaches is that background transduction levels are substantial even in the absence of the ligand or when using cells lacking the corresponding receptors due to the leakiness of the mutations that were introduced into the Sindbis virus E2 glycoprotein for abolishing cell binding. (biomedcentral.com)
  • However, this mutation reduced the production of reverse transcriptase-containing particles and infectious virus following transfection of permissive cells with virus DNA. (microbiologyresearch.org)
  • Despite EF-induced toxicity, murine or human mesenchymal stem cells (MSCs) tolerate expression, but only murine EF-transduced MSC displayed sarcoma formation upon transplantation in immunocompromised mice. (nature.com)
  • However, when cells were transduced by retrovirus to express BCL2 family members, they formed efficiently sarcomas in NSG mice. (nature.com)
  • The publication then considers the effects of invading organisms on cells and tissues in culture and cell, tissue, and organ cultures in virus research. (elsevier.com)
  • It also efficiently infects avian cells in culture and rapidly converts (transforms) them into tumor cells. (utdallas.edu)
  • however, such transformed cells do not release virus particles. (elsevier.com)
  • In all aspects examined, the behavior of myristylated Pr76 was identical to that of the authentic product produced in avian cells. (elsevier.com)
  • The AKR murine leukemia viruses do not contain acute transforming oncogenes ( 4 ) and are thought to transform cells as a result of activating cellular proto-oncogenes in the vicinity of viral integration into chromosomal DNA ( 5 ). (jimmunol.org)
  • Here it redirects the cellular machinery of the host to produce many new copies of the virus that go on to infect more cells. (bio-medicine.org)
  • He then went on to work out the energetic frequency of each of the different 'viruses' he found and even build a 'Rife Machine', or colloquially a zapper, which could adjust electrofrequency and kill off that particular 'virus' leaving healthy cells untouched. (canceractive.com)
  • This review is complemented by a discussion ofthe avian acute leukaemia viruses, which appears elsewhere in this volume [5]. (springer.com)
  • For this virus group, it is possible to compare the placement of de novo sites of integration generated experimentally to the preexisting distribution of ERVK sequences, allowing the forces dictating the accumulation of ERVs to be specified more precisely. (asm.org)
  • A phylogenetic tree based on the collection of RT-IN sequences for all retrotranscribing viruses in the NCBI taxonomy and NCBI RefSeq databases. (asmscience.org)
  • Full-length Pol or Gag-Pol sequences for all viruses were downloaded and truncated based on their alignment with the RT-IN region of HIV-1. (asmscience.org)
  • This proposed volume will attempt to review and address the major gaps in current knowledge in DNA viruses as well as RNA viruses bringing a historical perspective of where studies began to a more recent molecular approach and vaccine successes in tumor viruses. (indigo.ca)
  • Mouse Mammary Tumor Viruses - Susan Ross30. (indigo.ca)
  • The src oncogene of RSV became the prototype for dozens of other transforming genes in oncogenic viruses. (rupress.org)
  • 2000. Cospeciation and horizontal transmission of avian sarcoma and leukosis virus gag genes in galliform birds. (tolweb.org)
  • When the rabies virus enters a human cell through the membrane, the RNA molecule that carries its genes is transported into the centre of the cell. (bio-medicine.org)
  • Alterations in the genomes of avian sarcoma viruses. (fhcrc.org)
  • Six isolates of ALV-J, named SDAU1701-SDAU1706, were characterized by virus isolation and sequence analysis of the complete proviral genomes. (deepdyve.com)
  • It belongs to the retroviridae family and is closely related to HIV, the virus that causes AIDS. (newswise.com)
  • Rous sarcoma - a fibrosarcoma caused by certain viruses of family Retroviridae. (thefreedictionary.com)
  • There is serious concern that recombination with human influenza viruses may already have occurred raising the danger of human to human infection. (thefreedictionary.com)
  • Now the distinction between natural and artificial infection has long been known, although little regarded, in the discussion of plant viruses. (theperthgroup.com)
  • The formation of the mature carboxyl terminus of CA in avian sarcoma/leukemia virus is the result of a sequence of cleavage events at three PR sites that lie between CA and NC in the Gag polyprotein. (uthscsa.edu)
  • Viruses with single cysteine-to-serine mutations reverted to the wild-type sequence. (mendeley.com)
  • In a long and particularly close scientific collaboration with Dr. Varmus, Dr. Bishop showed beyond question that a DNA sequence in the avian sarcoma virus was virtually identical to a sequence in normal human DNA. (laskerfoundation.org)
  • We describe 12 nonconditional mutants of avian sarcoma virus. (fhcrc.org)
  • Biochemical and virus replication studies with these mutants strongly support the functional significance of the tetrameric architecture observed in the crystal structures. (plos.org)
  • We will also cover other known oncogenic viruses associated cancers in other mammals in addition to humans. (indigo.ca)
  • Oncogenic Viruses and Cancer Transmission- Robin Weiss6. (indigo.ca)
  • Symptoms of avian influenza in humans range from typical influenza-like symptoms to eye infections, pneumonia, acute respiratory distress, and other severe and life-threatening complications. (thefreedictionary.com)
  • Historically, close contact of fowl with humans has been shown epidemiologically to foster cross-species jump (avian to human) of new influenza strains (e.g. (thefreedictionary.com)
  • The only means of control when avian influenza has been observed in a flock of domestic fowl is destruction of infected birds and disinfection of the farm. (thefreedictionary.com)
  • Indeed, Rous warned, "The first tendency will be to regard the self-perpetuating agent active in this sarcoma of the fowl as a minute parasitic organism. (theperthgroup.com)
  • Viral glycoprotein-receptor interactions are required to initiate membrane fusion of the virus and cell. (wikipedia.org)
  • Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex. (semanticscholar.org)
  • Murine leukemia virus (MLV), in contrast, showed an integration bias in favor of CpG islands and transcription start sites ( 31 ) and a weaker preference for transcription units. (asm.org)
  • Cleavage of either 9 or 12 amino acids from the carboxyl terminus creates two mature CA species, named CA2 and CA3, that can be detected in avian sarcoma/leukemia virus (R. B. Pepinsky, I. A. Papayannopoulos, E. P. Chow, N. K. Krishna, R. C. Craven, and V. M. Vogt, J. Virol. (uthscsa.edu)
  • Rous-associated virus - a leukemia virus. (thefreedictionary.com)
  • Dr. Gallo's clinical and epidemiological studies have shown that the virus can infect some people without causing harm, but leads to leukemia in a susceptible few. (laskerfoundation.org)
  • Recent discoveries suggest that human T-cell leukemia virus or another similar to it may be involved in other types of disease. (laskerfoundation.org)
  • To Dr. Gallo, for his tenacious and thorough investigations leading to the discovery of the human T-cell leukemia virus and carrying resounding implications that will reshape approaches to cancer much sooner than scientists had expected or humanity had hoped, this 1982 Albert Lasker Basic Medical Research Award is given. (laskerfoundation.org)
  • Sarcoma, Avian" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • The surface glycoproteins contain the major domains that interact with the host cell receptor while the transmembrane (TM) glycoproteins anchor the surface glycoproteins to the virus membrane. (wikipedia.org)
  • Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding. (semanticscholar.org)
  • There are two ways viruses can enter the host cell: cell receptor endocytosis or fusion. (wikipedia.org)
  • Endocytosis is the process where the virus binds a receptor on the target cell membrane, and the virus is taken into or endocytosed into the cell. (wikipedia.org)
  • Jiri Vlach et al, Structural basis for targeting avian sarcoma virus Gag polyprotein to the plasma membrane for virus assembly, Journal of Biological Chemistry (2018). (phys.org)
  • Pseudotyped retroviral vectors consist of vector particles bearing envelope (Env) glycoproteins derived from other enveloped viruses. (biomedcentral.com)
  • CA and NC contain determinants for Gag multimerization, whereas p6 facilitates release of virus particles ( 1 , 2 ). (pnas.org)
  • Ten years earlier in an article entitled "The Plasmagene Theory of the Origin of Cancer", Darlington, discussing the induction of cancer by the Rous agent, the filtrable viruses and the "self-propagating" particles transmitted by heredity but lying outside the nucleus found in plants and "known as plasmagenes", wrote: "These infections, it will be seen, are artificial, or at least unnatural. (theperthgroup.com)
  • Four previously uncharacterized avian sarcoma viruses were screened and two of these, RPL30 and CTIO, were found to encode apparently novel oncogenes. (rockefeller.edu)
  • bird 'flu' caused by the H5N1 virus that caused epidemics in poultry in Japan, Korea, Thailand, China and Vietnam early in 2004. (thefreedictionary.com)
  • Marek's Disease Virus and T cell Lymphomas - Mark Parcells and Robin Morgan14. (indigo.ca)