The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl.
A group of transmissible viral diseases of chickens and turkeys. Liver tumors are found in most forms, but tumors can be found elsewhere.
A genus of the family RETROVIRIDAE with type C morphology, that causes malignant and other diseases in wild birds and domestic fowl.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Group of alpharetroviruses (ALPHARETROVIRUS) producing sarcomata and other tumors in chickens and other fowl and also in pigeons, ducks, and RATS.
An epithelial outgrowth of the cloaca in birds similar to the thymus in mammals. It atrophies within 6 months after birth and remains as a fibrous remnant in adult birds. It is composed of lymphoid tissue and prior to involution, is the site of B-lymphocyte maturation.
Proteins obtained from species of BIRDS.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
A species in the group RETICULOENDOTHELIOSIS VIRUSES, AVIAN of the genus GAMMARETROVIRUS that causes a chronic neoplastic and a more acute immunosuppressive disease in fowl.
Connective tissue tumors, affecting primarily fowl, that are usually caused by avian sarcoma viruses.
Common name for two distinct groups of BIRDS in the order GALLIFORMES: the New World or American quails of the family Odontophoridae and the Old World quails in the genus COTURNIX, family Phasianidae.
DNA sequences that form the coding region for retroviral enzymes including reverse transcriptase, protease, and endonuclease/integrase. "pol" is short for polymerase, the enzyme class of reverse transcriptase.
A genus of BIRDS in the family Phasianidae, order GALLIFORMES, containing the common European and other Old World QUAIL.
Deoxyribonucleic acid that makes up the genetic material of viruses.
DNA sequences that form the coding region for the viral envelope (env) proteins in retroviruses. The env genes contain a cis-acting RNA target sequence for the rev protein (= GENE PRODUCTS, REV), termed the rev-responsive element (RRE).
Duplex DNA sequences in eukaryotic chromosomes, corresponding to the genome of a virus, that are transmitted from one cell generation to the next without causing lysis of the host. Proviruses are often associated with neoplastic cell transformation and are key features of retrovirus biology.
DNA sequences that form the coding region for proteins associated with the viral core in retroviruses. gag is short for group-specific antigen.
A species of ALPHARETROVIRUS causing anemia in fowl.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
The type species of the genus MARDIVIRUS in the family HERPESVIRIDAE. It is the etiologic agent of MAREK DISEASE, infecting domestic fowl and wild birds.
Ribonucleic acid that makes up the genetic material of viruses.
A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye.
The functional hereditary units of VIRUSES.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A general term for various neoplastic diseases of the lymphoid tissue.
Retroviruses that have integrated into the germline (PROVIRUSES) that have lost infectious capability but retained the capability to transpose.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.
A phenomenon in which infection by a first virus results in resistance of cells or tissues to infection by a second, unrelated virus.
Established cell cultures that have the potential to propagate indefinitely.
Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.
Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.
A lymphoid neoplastic disease in cattle caused by the bovine leukemia virus. Enzootic bovine leukosis may take the form of lymphosarcoma, malignant lymphoma, or leukemia but the presence of malignant cells in the blood is not a consistent finding.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.
Proteins from the family Retroviridae. The most frequently encountered member of this family is the Rous sarcoma virus protein.
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
Substances elaborated by viruses that have antigenic activity.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Viruses whose genetic material is RNA.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Proteins found in any species of virus.
Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Process of growing viruses in live animals, plants, or cultured cells.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.

Genome structure and expression of the ev/J family of avian endogenous viruses. (1/808)

We recently reported the identification of sequences in the chicken genome that show over 95% identity to the novel envelope gene of the subgroup J avian leukosis virus (S. J. Benson, B. L. Ruis, A. M. Fadly, and K. F. Conklin, J. Virol. 72:10157-10164, 1998). Based on the fact that the endogenous subgroup J-related env genes were associated with long terminal repeats (LTRs), we concluded that these LTR-env sequences defined a new family of avian endogenous viruses that we designated the ev/J family. In this report, we have further characterized the content and expression of the ev/J proviruses. The data obtained indicate that there are between 6 and 11 copies of ev/J proviruses in all chicken cells examined and that these proviruses fall into six classes. Of the 18 proviruses examined, all share a high degree of sequence identity and all contain an internal deletion that removes all of the pol gene and various amounts of gag and env gene sequences. Sequencing of the gag genes, LTRs, and untranslated regions of several ev/J proviruses revealed a high level of identity between isolates, indicating that they have not undergone significant sequence variation since their introduction into the avian germ line. Although the ev/J gag gene showed a relatively weak relationship (46% identity and 61% similarity at the amino acid level) to that of the avian leukosis-sarcoma virus family, it retains several sequences of demonstrated importance for virus assembly, budding, and/or infectivity. Finally, evidence was obtained that at least some members of the ev/J family are expressed and, if translated, could encode Gag- and Env-related polypeptides.  (+info)

Evidence of avian leukosis virus subgroup E and endogenous avian virus in measles and mumps vaccines derived from chicken cells: investigation of transmission to vaccine recipients. (2/808)

Reverse transcriptase (RT) activity has been detected recently in all chicken cell-derived measles and mumps vaccines. A study of a vaccine manufactured in Europe indicated that the RT is associated with particles containing endogenous avian retrovirus (EAV-0) RNA and originates from the chicken embryonic fibroblasts (CEF) used as a substrate for propagation of the vaccine. We investigated the origin of RT in measles and mumps vaccines from a U.S. manufacturer and confirm the presence of RT and EAV RNA. Additionally, we provide new evidence for the presence of avian leukosis virus (ALV) in both CEF supernatants and vaccines. ALV pol sequences were first identified in particle-associated RNA by amplification with degenerate retroviral pol primers. ALV RNA sequences from both the gag and env regions were also detected. Analysis of hypervariable region 2 of env revealed a subgroup E sequence, an endogenous-type ALV. Both CEF- and vaccine-derived RT activity could be blocked by antibodies to ALV RT. Release of ALV-like virus particles from uninoculated CEF was also documented by electron microscopy. Nonetheless, infectivity studies on susceptible 15B1 chicken cells gave no evidence of infectious ALV, which is consistent with the phenotypes of the ev loci identified in the CEF. PCR analysis of ALV and EAV proviral sequences in peripheral blood mononuclear cells from 33 children after measles and mumps vaccination yielded negative results. Our data indicate that the sources of RT activity in all RT-positive measles and mumps vaccines may not be similar and depend on the particular endogenous retroviral loci present in the chicken cell substrate used. The present data do not support transmission of either ALV or EAV to recipients of the U.S.-made vaccine and provide reassurance for current immunization policies.  (+info)

An avian sarcoma/leukosis virus-based gene trap vector for mammalian cells. (3/808)

RCASBP-M2C is a retroviral vector derived from an avian sarcoma/leukosis virus which has been modified so that it uses the envelope gene from an amphotropic murine leukemia virus (E. V. Barsov and S. H. Hughes, J. Virol. 70:3922-3929, 1996). The vector replicates efficiently in avian cells and infects, but does not replicate in, mammalian cells. This makes the vector useful for gene delivery, mutagenesis, and other applications in mammalian systems. Here we describe the development of a derivative of RCASBP-M2C, pGT-GFP, that can be used in gene trap experiments in mammalian cells. The gene trap vector pGT-GFP contains a green fluorescent protein (GFP) reporter gene. Appropriate insertion of the vector into genes causes GFP expression; this facilitates the rapid enrichment and cloning of the trapped cells and provides an opportunity to select subpopulations of trapped cells based on the subcellular localization of GFP. With this vector, we have generated about 90 gene-trapped lines using D17 and NIH 3T3 cells. Five trapped NIH 3T3 lines were selected based on the distribution of GFP in cells. The cellular genes disrupted by viral integration have been identified in four of these lines by using a 5' rapid amplification of cDNA ends protocol.  (+info)

Studies of the genomic RNA of leukosis viruses: implications for RNA dimerization. (4/808)

Retroviral particles contain two positive-strand genomic RNAs linked together by noncovalent bonds that can be dissociated under mild conditions. We studied genomic RNAs of wild-type and mutant avian leukosis viruses (ALVs) in an attempt to (i) better understand the site(s) of RNA dimerization, (ii) examine whether the primer binding site (PBS) and tRNA primer are involved in dimerization, and (iii) determine the structure of genomic RNA in protease-deficient (PR(-)) mutants. We showed that extensively nicked wild-type ALV genomic RNAs melt cooperatively. This implies a complex secondary and/or tertiary structure for these RNAs that extends well beyond the 5' dimerization site. To investigate the role of the PBS-tRNA complex in dimerization, we analyzed genomic RNAs from mutant viruses in which the tRNA(Trp) PBS had been replaced with sequences homologous to the 3' end of six other chicken tRNAs. We found the genomic RNAs of these viruses are dimers that dissociate at the same temperature as wild-type viral RNA, which suggests that the identity of the PBS and the tRNA primer do not affect dimer stability. We studied two ALV PR(-) mutants: one containing a large (>1.9-kb) inversion spanning the 3' end of gag and much of pol, rendering it deficient in PR, reverse transcriptase, and integrase, and another with a point mutation in PR. In both of these mutant viruses, the genomic RNA appears to be either primarily or exclusively monomeric. These data suggest that ALV can package its RNA as monomers that subsequently dimerize.  (+info)

Point mutations in the avian sarcoma/leukosis virus 3' untranslated region result in a packaging defect. (5/808)

The 3' untranslated region (3' UTR) between the 3' end of env and the long terminal repeat is well conserved among avian retroviruses and is essential for efficient replication. Deletion of the dr1 element within the 3' UTR has been reported to have various effects, including reduced levels of unspliced RNA in the cytoplasm, decreased stability of unspliced RNA, decreased particle production, and decreased genomic RNA packaging. To probe the role of specific sequences within dr1 in virus replication, site-directed mutagenesis was utilized to perturb parts of the predicted secondary structure of dr1. Seven of thirteen mutations had no significant effect; the others resulted in an approximately 10- to 20-fold reduction in replication. These mutants were further characterized and found to impair cytoplasmic accumulation of unspliced RNA only slightly. Furthermore, no decreases were observed in the stability of the unspliced RNA or in the production of virus particles. Genomic RNA packaging, however, was reduced by about 10-fold. Similar amounts of particles were produced by cells containing the mutant and wild-type DNA, and all particles contained similar levels of reverse transcriptase activity. The results suggest that the region of the dr1 disrupted by the mutations plays a role in genomic RNA packaging, although that packaging may not be the only role for dr1.  (+info)

Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types. (6/808)

Successful targeting methods represent a major hurdle to the use of retroviral vectors in cell-specific gene-delivery applications. We recently described an approach for retroviral targeting with a retroviral receptor-ligand bridge protein that was bound to the cognate cell-surface ligand receptors before viral challenge. We now report a significant improvement made to this viral targeting method by using a related bridge protein, designated TVB-EGF, comprised of the extracellular domain of the TVB receptor for subgroup B avian leukosis virus fused to epidermal growth factor (EGF). The most important activity of TVB-EGF was that it allowed specific viral entry when preloaded onto virions. Furthermore, virions preloaded with TVB-EGF were thermostable and could be produced directly from virus- packaging cells. These data suggest an approach for targeting retroviral vectors to specific cell types by using virions preloaded with a retroviral receptor-ligand bridge protein and indicate that these types of bridge proteins may be useful reagents for studying the normal mechanism of retroviral entry.  (+info)

Production and design of more effective avian replication-incompetent retroviral vectors. (7/808)

Retroviral vectors have been invaluable tools for studies of development in vertebrates. Their use has been somewhat constrained, however, by the low viral titers typically obtained with replication-incompetent vectors, particularly of the avian type. We have addressed this problem in several ways. We optimized the transient production of avian replication-incompetent viruses in a series of cell lines. One of the optimal cell lines was the mammalian line 293T, which was surprising in light of previous reports that avian viral replication was not supported by mammalian cells. We also greatly increased the efficiency of viral infection. Pseudotyping with the vesicular stomatitus virus G (VSV-G) protein led to an over 350-fold increase in the efficiency of infection in ovo relative to infection with virus particles bearing an avian retroviral envelope protein. To further increase the utility of the system, we developed new Rous sarcoma virus (RSV)-based replication-incompetent vectors, designed to express a histochemical marker gene, human placental alkaline phosphatase, as well as an additional gene. These modified retroviral vectors and the VSV-G pseudotyping technique constitute significant improvements that allow for expanded use of avian replication-incompetent viral vectors in ovo.  (+info)

A genetically engineered cell line resistant to subgroup J avian leukosis virus infection (C/J). (8/808)

A cell line (DF-1 inverted question markJ) expressing the envelope protein isolated from the ADOL-Hc1 strain of the avian leukosis virus subgroup J (ALV-J) was used to analyze receptor interference to six different isolates of ALV-J as well as ALV subgroups A-D. The traditional gag-specific enzyme-linked immunosorbent assay (ELISA) as well as flow cytometry was used to evaluate viral infection. The parental cell line (DF-1) was susceptible to all ALV subgroups tested while the DF-1 inverted question markJ cell line was selectively resistant to the subgroup J isolates. The DF-1 inverted question markJ cell line was resistant to infection by all six ALV-J isolates as determined using the gag-specific ELISA. There was no interference with the other ALV subgroups (A-D) induced by the expression of the ADOL-Hcl envelope. The ALV-J isolates used in this analysis are serologically distinct when analyzed by flow cytometry. Convalescent sera to ADOL-Hcl cross-reacts with all of the ALV-J isolates tested; however, sera to HPRS-103 did not bind to four of the six isolates. Based on the intensity and differential binding of these antisera using flow cytometry, the six ALV-J isolates used can be grouped into four categories. Thus the DF-1 inverted question markJ cell line is resistant to infection by a serologically and genetically diverse group of ALV-J isolates and should be useful as a diagnostic tool.  (+info)

Avian sarcoma leukosis virus (ASLV) is an endogenous retrovirus that infects and can lead to cancer in chickens; experimentally it can infect other species of birds and mammals. ASLV replicates in chicken embryo fibroblasts, the cells that contribute to the formation of connective tissues. Lymphoid leukosis is the most common form of this disease and with typical presentation of gradual onset, persistent low mortality, and neoplasia of the bursa. Subgroups A, B, E and J are the major subgroups of avian leukosis virus (ALV) infecting chickens. ALV infection has become endemic in many countries and has a significant negative effect on the poultry industry.. ...
HPRS-103, the prototype of avian leukosis virus (ALV) subgroup J, was isolated in 1989 from meat-type chickens from commercial flocks where it induces myelocytic myeloid leukosis (ML). The HPRS-103 env gene differs considerably from other ALV subgroups but shows high identity (75-97%) to env-like sequences of the different members of the EAV family of endogenous avian retroviruses. Recently, we have isolated several viruses related to HPRS-103 from cases of ML. Although these isolates showed properties of ALV subgroup J, the majority of them resisted neutralization by HPRS-103-specific serum, suggesting antigenic variation. The nucleotide sequence of the env gene of the variant viruses showed several substitutions resulting in amino acid changes especially clustered in the variable regions hr1, hr2 and vr3. Analysis of the data suggests that selection pressure, probably from the immune response, is driving the antigenic variation among the isolates. Phylogenetic analysis of the sequences showed the
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above. ...
The host ranges of the Rous sarcoma virus (RSV) pseudotype RSV(HPRS-103) of a novel avian leukosis virus (ALV), strain HPRS-103, and representative RSV pseudotypes of subgroups A to F, have been determined in embryo fibroblasts from 12 avian species. Domestic fowl, red jungle fowl, Sonnerat's jungle fowl and turkey were susceptible to infection by RSV(HPRS-103); ring-necked pheasant, Japanese green pheasant, golden pheasant, Japanese quail, guinea-fowl, Peking duck, Muscovy duck and goose were resistant. The host range pattern of RSV(HPRS-103) differs from those of viruses of subgroups A to G and I, and provides support for placing the HPRS-103 strain of ALV in a new envelope subgroup, designated J.
We have previously described avian leukosis virus-based packaging cell lines that express gag, pol, and env proteins from two transcomplementing genomes and produce helper-free stocks of retroviral vectors with different host ranges. In this report, we demonstrated that (i) despite the deletion of the psi packaging sequence, the packaging-defective transcomplementing retroviral transcripts were packaged into virions at a level that could reach 2.3% of a wild-type virus packaging level and (ii) despite deletion of the 3 LTR, these genomes were transferred along with the vector to target cells. As these genomes were also bearing a selectable gene, titers of the resulting contaminant particles could be estimated, depending on the cell line to be between 0 and 6 infectious particles/ml of supernatant.
Traditionally, virus isolates have been named most commonly for the disease from which they were isolated - e.g. influenza, poliomyelitis, visna, foot-and-mouth disease, and the like. A smaller number are named for the place of isolation - Coxsackie, Sindbis, and Sendai viruses are a few examples, and a mercifully small number are named for their discoverers - alone or in combination with other features - such as Epstein-Barr virus, Rous sarcoma virus, etc. With retroviruses, it is also usual to append the species of origin to the name - avian leukosis virus, human T-cell lymphoma virus, baboon endogenous virus, etc. Unlike most other organisms, the naming of new virus isolates has usually been a trivial prerogative of the isolator, and not subject to review by other workers in the field . This has, in general, caused little difficulty so long as the names chosen were novel and did not presuppose unproven relationships. Significant confusion has been created in the past, however, by injudicious ...
Induction of lymphomas in the bursa of Fabricius of chickens by replication competent, non-transforming avian retroviruses (Avian Leukosis Virus, ALV) is both an economically significant, naturally...
Compare E26 avian leukemia oncogene 2, 3 domain Biomolecules from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
A team led by Xin Li, Ph.D., assistant professor in the departments of Biochemistry and Biophysics and Urology at the University of Rochester School of Medicine and Dentistry, analyzed rooster testes to find out.. Chickens acquire and harbor a wide variety of viruses. When a virus infects a host, like a chicken, it does everything it can to survive. One method of survival is inserting its genetic material into the chickens genome. Over generations, the inserted virus accumulates mutations and eventually becomes harmless to the animal, but its still a part of the chickens genetic material.. Lis team focused on avian leukosis virus, which commonly infects and can lead to cancer in domestic chickens. Through molecular and genetic analysis, they discovered that chickens turn these old, existing viruses into piRNA-producing machines. When faced with a new avian leucosis virus (there are many different viruses in the family), the old viruses pump out piRNAs that defend the germ cells, ensuring the ...
The avian acute leukemia virus (E26) induces a mixed erythroidmyeloid leukemia in chickens and carries two distinct oncogenes, v-myb and v-ets. The viral protein responsible for transformation is a gag-myb-ets fusion protein that is located in the nucleus of the transformed cells. The cellular homologue of v-ets (c-ets-1) is highly expressed in lymphoid cells and differs from the v-ets gene at its carboxy terminal region. Here, we show that both the c-ets-1 and v-ets gene products are DNA-binding proteins and their DNA-binding activity is located in the carboxy terminal (46 amino acid residues) region. It appears that this DNA-binding activity is modulated by the extreme carboxy terminal region. The amino acid sequences of the putative ets DNA-binding domain at its carboxy terminal region showed a helix-turn-helix secondary structure. Exchanging the nonhomologous extreme carboxy terminal regions of c-ets-1 with v-ets gene sequences showed differences in DNA-binding affinity, indicating that ...
Edited by John M. Coffin, Tufts University School of Medicine, Boston, MA (received for review February 24, 2004) ArticleFigures SIInfo gt;5 kDa in size are required. Furthermore, later steps of avian sarcoma and leukosis virus reverse tran
ETS1 (phospho Thr38) antibody (E26 avian leukemia oncogene 1, 5 domain) for ICC/IF, IHC-P, WB. Anti-ETS1 (phospho Thr38) pAb (GTX55307) is tested in Human, Mouse samples. 100% Ab-Assurance.
Exogenote exogenote the new chromosomal fragment do- nated to a merozygote (q.v.). exogenous DNA DNA that originates outside an organism (e.g., from another cell or virus). exogenous virus a virus ...
used to derive intake values did not include consideration for other applications. However, with the increasing globalization of information and the identification of a variety of factors specific to different population subgroups (e.g ...
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Incidence of avian leukosis virus infection in broiler stocks and its effect on early growth.: Twenty-eight broiler breeder flocks were tested for avian leukosi
TY - JOUR. T1 - Proper processing of avian sarcoma/leukosis virus capsid proteins is required for infectivity. AU - Xiang, Y.. AU - Thorick, R.. AU - Vana, M. L.. AU - Craven, R.. AU - Leis, J.. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 2001. Y1 - 2001. N2 - The formation of the mature carboxyl terminus of CA in avian sarcoma/leukemia virus is the result of a sequence of cleavage events at three PR sites that lie between CA and NC in the Gag polyprotein. The initial cleavage forms the amino terminus of the NC protein and releases an immature CA, named CA1, with a spacer peptide at its carboxyl terminus. Cleavage of either 9 or 12 amino acids from the carboxyl terminus creates two mature CA species, named CA2 and CA3, that can be detected in avian sarcoma/leukemia virus (R. B. Pepinsky, I. A. Papayannopoulos, E. P. Chow, N. K. Krishna, R. C. Craven, and V. M. Vogt, J. Virol. 69:6430-6438, 1995). To study the importance of each of the three CA proteins, we introduced ...
Subgroups A, B, E and J are the major subgroups of avian leukosis virus (ALV) infecting chickens. ALV infection has become endemic in China and has a significant negative effect on the poultry industry. Consequently, there is an urgent need for a specific, sensitive and rapid method for diagnosis and eradication of ALV. Therefore, we developed a simple and rapid real-time loop-mediated isothermal amplification (LAMP) reaction for the timely detection of the common ALV subgroups, whereby the amplification can be obtained in 35 min under isothermal conditions at 63 °C, ability to specific, sensitive and rapid detect all the common ALV subgroups. A set of four specific primers was designed to target the sequences of the pol gene of ALV, and the loop-mediated isothermal amplification (LAMP) assay were developed and compared with PCR and virus isolation methods. The results from specificity of the LAMP assay showed that only target ALVs DNA was amplified. The LAMP assay demonstrated a sensitivity of 20
Chicken endogenous viruses, ALVE (Avian Leukosis Virus subgroup E), are inherited as LTR (long terminal repeat) retrotransposons, which are negatively correlated with disease resistance, and any changes in DNA methylation may contribute to the susceptibility to neoplastic disease. The relationship between ALVE methylation status and neoplastic disease in the chicken is undefined. White Leghorn inbred lines 72 and 63 at the ADOL have been respectively selected for resistance and susceptibility to tumors that are induced by avian viruses. In this study, the DNA methylation patterns of 3∼6 CpG sites of four conserved regions in ALVE, including one unique region in ALVE1, the promoter region in the TVB (tumor virus receptor of ALV subgroup B, D and E) locus, were analyzed in the two lines using pyrosequencing methods in four tissues, i.e., liver, spleen, blood and hypothalamus. A significant CpG hypermethylation level was seen in line 72 in all four tissues, e.g., 91.86±1.63% for ALVE region2 in blood,
Morbidity is low but mortality high. Mortality tends to be chronically higher than normal for a prolonged period. Egg production is somewhat reduced. There may be increased susceptibility to other infectious diseases due to damage to the immune system. Vertical transmission is most important by infection of the egg white in infected breeders (who are long-term carriers), lateral transmission is poor but infection may occur by the faecal-oral route, especially in young birds. In lymphoid leukosis the incubation period is about 4-6 months; it may be as short as 6 weeks for some of the other manifestations. The causative viruses are rapidly inactivated at ambient temperature and on exposure to most disinfectants ...
Avian leukosis virus (ALV)-induced osteopetrosis is a proliferative disorder of the bone affecting the growth and differentiation of osteoblasts. Osteopetrosis is a polyclonal disease in which cells of the bone contain, on average, multiple viral DNA copies. Osteopetrotic bone is also characterized by the accumulation of unintegrated viral DNA, suggesting an atypical life cycle of the virus in the infected osteoblasts. To better understand virus-host interactions in the induction of osteopetrosis by ALVs, infected chick osteoblast cultures and osteopetrotic bone were examined for aspects of the virus life cycle and effects of infection on osteoblast function. Levels of infection and virus expression were compared in cultured osteoblasts and osteopetrotic bone. Osteopetrotic bone contained higher levels of viral DNA and correspondingly higher levels of viral proteins than infected osteoblast cultures, suggesting a higher viral load in the diseased bone. A significant level of mature Gag protein was
In addition to neoplasias caused in chickens by helper viruses of the avian myeloblastosis virus (AMV) complex, acute myeloblastic leukemia is induced by a defective leukemogenic component. To...
Avian myeloblastosis ATCC ® VR-1542AS-Gt™ Designation: antiserum against AMV RT [NCI HE 599] Application: goat antiserum against the Avian Myeloblastosis Virus (AMV) Reverse Transcriptase (RT)
TY - JOUR. T1 - Disease tropism of c-erbB. T2 - Effects of carboxyl-terminal tyrosine and internal mutations on tissue-specific transformation. AU - Pelley, R. J.. AU - Maihle, Nita Jane. AU - Boerkoel, C.. AU - Shu, H. K.. AU - Carter, T. H.. AU - Moscovici, C.. AU - Kung, H. J.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - Avian leukosis virus induces erythroleukemia in chickens by proviral insertional mutation of the proto-oncogene c-erbB. The product of the insertionally activated c-erbB locus lacks the extracellular ligand-binding domain and is strictly leukemogenic. It has previously been demonstrated that the disease spectrum associated with aberrant c-erbB expression can be expanded by structural perturbation of the cytoplasmic domain of this protein. In this report, we use mutagenesis and retroviral vectors to identify specific mutations in the carboxyl-terminal domain of the insertionally activated c-erbB product that are sufficient to activate the sarcomagenic potential of this protein. ...
Up-regulation of the v-Myb avian myeloblastosis viral oncogene homolog-like2 B-Myb (MYBL2) gene occurs in human hepatocellular carcinoma (HCC) and is associated with faster progression of rodent hepatocarcinogenesis. We evaluated, in distinct human HCC prognostic subtypes (as defined by patient survival length), activation of MYBL2 and MYBL2-related genes, and relationships of p53 status with MYBL2 activity. Highest total and phosphorylated protein levels of MYBL2, E2F1-DP1, inactivated retinoblastoma protein (pRB), and cyclin B1 occurred in HCC with poorer outcome (HCCP), compared to HCC with better outcome (HCCB). In HCCP, highest LIN9-MYBL2 complex (LINC) and lowest inactive LIN9-p130 complex levels occurred. MYBL2 positively correlated with HCC genomic instability, proliferation, and microvessel density, and negatively with apoptosis. Higher MYBL2/LINC activation in HCC with mutated p53 was in contrast with LINC inactivation in HCC harboring wildtype p53. Small interfering RNA ...
Its another beautiful day on the Old McDonald|farm, and having fed and watered the horses, cows, sheep, and other assorted barnyard animals, you decide...
TY - JOUR. T1 - Leukosis mathematical model. AU - Kolpak, Eugeny Petrovich. AU - Abuzyarova, Raisa Tagirovna. AU - Kabrits, Sergey Alexandrovich. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Aim and Scope: The present study is about developing the mathematical model of leukosis according to modern data on hematopoiesis among mammals. Materials and Methods: Three types of cells are considered in the model, one of which is represented by leukemic ones. The interaction of cells is considered as the competition for the functional space of dividing cells. For leukemia cells are the cells dividing at a higher speed as compared to all the others. Results and Discussion: The model of leukemic cells replacement with donor cells is considered as the introduction of more active cells than leukemic ones. The model is represented by the Cauchy problem for the system of ordinary differential equations. Conclusion: The violation of hematopoiesis functions is compared with a leading parameter change, which transfers the ...
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint ...
anti-V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) (pThr358), (AA 340-385) antibody (Cy5.5) ABIN752598 from antibodies-online
Primers 1 and 2 were designed from the mRNA of a guinea pig BK B2 receptor (GenBank accession no. AJ003243) to amplify a 500-base pair fragment. Primers 3 and 4 were a pair of degenerate primers used to amplify a 401-base pair fragment for the guinea pig BK B1 receptor. Primers 3 and 4 were made from the conserved region between mouse BK B1 receptor (GenBank accession no. NM_007539) and rat BK B1 receptor (GenBank accession no. U66107). Amplification was done with an iCycler (Bio-Rad, Hercules, CA). PCR cycles consisted of denaturation for 1 min at 94°C, annealing at 56°C for 90 s, and extension at 72°C for 90 s. A total of 30 cycles was followed by completion of extension for 7 min at 72°C. PCR product (12 μl) was analyzed by electrophoresis on 2% agarose gel. Sequencing was done with an ABI 373XL DNA sequencer after the PCR product was purified with Qiaquick PCR purification kit (QIAGEN, Valencia, CA). RT-PCR without avian myeloblastosis virus reverse transcriptase was used as a negative ...
RT Components: 1U/mL RNase inhibitor, 0.625U/mL reverse transcriptase (avian myeloblastosis virus, Boehringer), 1microM G1 primer, 1.75mM dNTPs ...
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
In reply to your comment, or should I say link since you did not add any thoughts on the matter I would like to say that HIV was observed in laboratory test under artificial stress and its appearance was endogenous. There is to date no picture of this virus observed by electron microscopy in the blood of a patient whose said they have a high viral load . More HIV is not an exogenous virus as people who make these claims seem to suggest , but a retrovirus, it is an important difference because our DNA contains 1% of endogenous retroviruses that may under certain conditions trigger diseases ... especially as those found in AIDS. But the question is , what makes the sick cell , why are these scientists able to identify this retro virus in a test tube , but never in humans ...
Hello,. Sometime because of large data or output users set the program to execute in background process.. Once the background job is get completed, they execute the SM37 T-code to view the information, but that information is in list view,. their they does not an option like, sorting, filtering and all.. Its a program, where user are getting the same functionality, but the output will display in ALV format, there they will get the all necessary option to format the data.. Basically the program is created based on the Z* programs, so it will be execute in only for the ALV grid output data.. ...
Indicator values are prone to statistical error (the difference between an estimated value and the true value). The statistical error associated with an indicator depends on the population subgroup (e.g. the population of a county or LGD) that it refers to. Such differences in levels of statistical error can distort what we see in maps and charts. They can make some relationships involving indicators and attributes appear real (practically meaningful or statistically significant) when they are in fact spurious; other relationships that are real can be masked. These differences in statistical error can even distort the shape of plots or the colour patterns we see in maps. For example, ...
Indicator values are prone to statistical error (the difference between an estimated value and the true value). The statistical error associated with an indicator depends on the population subgroup (e.g. the population of a county or LGD) that it refers to. Such differences in levels of statistical error can distort what we see in maps and charts. They can make some relationships involving indicators and attributes appear real (practically meaningful or statistically significant) when they are in fact spurious; other relationships that are real can be masked. These differences in statistical error can even distort the shape of plots or the colour patterns we see in maps. For example, ...
TY - JOUR. T1 - Sequence-specific DNA binding by the v-erbA oncogene protein of avian erythroblastosis virus. AU - Bonde, Beverly Geary. AU - Privalsky, Martin L.. PY - 1990. Y1 - 1990. N2 - The v-erbA oncogene, a transduced copy of a thyroid hormone receptor, plays an important role in establishment of the transformed cell phenotype induced by avian erythroblastosis virus. The ability of thyroid hormone receptors to bind to specific sites on chromatin and to thereby modify the expression of adjacent target genes is a crucial element in their mechanism of action in the normal cell. The v-erbA protein also bound at high affinity to a set of DNA fragments recognized by the rat thyroid hormone receptor, but the relative affinity of the v-erbA protein for the different binding sites was distinct from that previously reported for the thyroid hormone receptors.. AB - The v-erbA oncogene, a transduced copy of a thyroid hormone receptor, plays an important role in establishment of the transformed cell ...
Bovine Leukosis is a disease caused by the Bovine Leukosis virus (BLV). This is a blood borne disease that dwells in the lymphocytes (white blood cells) in cattle. Only 5% of infected animals will exhibit the clinical symptoms of developing tumors in lymphatic tissue. The prevalence ofleukosis is wide spread. It is fairly common to find herds with a prevalence of 80-90%, however not very common to find herds that are completely free of leukosis. According to the NAHMS 96 study, 88.5% of dairy herds and 38.7% of beef herds are infected. Transmission occurs by the transfer of bodily fluids that contain infected white cells (blood, colostrum, milk). Anything from reusing without sanitizing contaminated needles, syringes, breeding sleeves, dehorners, or balling guns can transmit leukosis. Transmission can also occur through colostrum or to a fetus in utero. ...
Rosok, Mae Joanne, Dissociation and isolation of the subunits of avian myeloblastosis virus RNA-directed DNA polymerase (1977). Graduate Student Theses, Dissertations, & Professional Papers. 6828 ...
hypothetical protein, transcription factor protein, A306_09622, anon-WO03040301.171, avian myelocytomatosis viral oncogene homolog, avian myelocytomatosis viral (v-myc) oncogene homolog, bHLHe39, bHLHe57, cellular myelocytomatosis oncogene, CG10798 gene product from transcript CG10798-RB, CG10798-PA, CG10798-PB, class E basic helix-loop-helix protein 39, cmyc, c-MYC, c-myc20, c-Myc-a, c-Myc-b, c-myc-like protein, c-myc proto-oncogene, diminuitive, diminutive, DM, dm/dMyc, Dmel_CG10798, dm/myc, d-myc, dMYC, dmyc1, EG:BACN5I9.1, EGK_19271, lethal (1) G0354, lethal (1) G0359, MDA_GLEAN10014535, mMyc, MRTL, Myc2, myc-a, myc-b, MYCC, Myc-PA, Myc-PB, myc proto-oncogene protein, myc-related translation/localization regulatory factor, myelocytomatosis oncogene, myelocytomatosis viral oncogene homolog, N303_07797, N307_12984, N309_06569, Niard, Nird, oncoprotein myc, PAL_GLEAN10003365, Proto-oncogene c-Myc, RNCMYC, transcription factor Myc, transcription factor p64, TREES_T100017263, uncharacterized ...
The avian myeloblastosis virus (AMV) is an alpha retrovirus responsible for acute myeloblastic leukemia (AML) when injected in ovo, or in newly hatched chickens [10]. Early in vitro dose response experiments indicated that the production of virion with leukemogenic potential required a double infection with AMV and a helper virus [11]. The AMV strains that are used and commercially available, are derived from the orignal BAI strain A purified from chicken leukemic plasma [12]. Leukemic plasma containing the BAI strain has been widely distributed for many years by Life Sciences Inc., in Florida which has been the official provider of national agencies in the USA. The Standard AMV-S BAI strain is a complex mixture of viruses that also includes two helper viruses in addition to AMV. The helper viruses Myeoloblastosis Associated Virus (MAV) contained in AMV-S belong to two different serological subgoups (type1 and type2, also called A and B). Both of them are oncogenic [13].. Both MAV-1 and MAV-2 ...
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species ...
ERG antibody, Internal (v-ets avian erythroblastosis virus E26 oncogene homolog) for WB. Anti-ERG pAb (GTX77743) is tested in Human samples. 100% Ab-Assurance.
A testi és szellemi egészség szempontjából fontos a megfelelő éjszakai alvás. Az óra segítségével nyomon követheti az alvását, és figyelheti, hogy átlagosan hány órát alszik.. Ha az órát alvás közben is viseli, a Suunto Spartan Trainer Wrist HR a gyorsulásmérő adatai alapján nyomon követi az alvását. Amikor lefekszik, az órát leteheti az ágy mellé, de javasoljuk, hogy hagyja a karján, mivel így pontosabb adatokat kap az alvásáról.. Az alvás nyomon követéséhez: ...
Glynn, J P.; Halpern, B L.; and Fefer, A, An immunochemotherapeutic system for the treatment of a transplanted moloney virus-induced lymphoma in mice. (1969). Subject Strain Bibliography 1969. 913 ...
Terms Related to the Moving Wall Fixed walls: Journals with no new volumes being added to the archive. During an 8-year period, we retrospectively collected data on all travelers hospitalized in our department for a CMI occurring during travel or in the month after their return. During an 8‐year period, we retrospectively collected data on all travelers hospitalized in our department for a CMI occurring during travel or in the month after their return. The sensitivity and versatility of this technique (immunofixation can be applied to the detection of any antigen) should permit its extension to other biological fluids with a low protein content. Exogenous viruses including bacteriophage and human herpes viruses-4, -5 and -6 were detected variably in autopsied brains from both clinical groups. This case highlights the challenges of early recognition, accurate diagnosis, appropriate treatment and follow-up of such patients. A small number of children have CP as the result of brain damage in the ...
The product of both the viral and cellular myc genes has been implicated as being a primary mediator of events leading to cellular transformation. In addition,...
Model TVB613 TV BOX non-metallic, combination power and low voltage recessed box is ideal for flat screen televisions. Learn More!
n miben szokott aludni? T len pizsam ban, ny ron h l ingben vagy als nadr gban? B rmelyik legyen is a v lasz, tudnia kell, hogy rosszul teszi. me hat meglep ok, ami rt rdemes lenne meztelen l aludnia.
Здравсвуйте пользователи форума amv.at.ua, вчера пользователь под ником Olechkalype просила меня выложить супермодные новинки Компьютерные аксессуары/Графические планшеты в 2014, а так же сотовые бренда Intuos Pro Special Ed., так вот наконецто нашла время для этого, админы прошу не удалять, а перенести в соответствующий раздел, если я ошиблась например Компьютерные аксессуары/Графические планшеты ))) всех обнимаю ...
Пожалуй, самым разочаровывающим итогом 2013 года стало сползание в экономический застой. На протяжении года снижались как темпы роста промышленности, так и ВВП. Если в начале года еще казалось, что экономика вот-вот разгонится и из состояния «технической рецессии» войдет в фазу роста, то уже весной тональность заявлений финансовых властей смен ...
Vendredi 22 mars 2013 à 11h30 , Amélie Peres, ENS Paris. Titre : Etude de lévolution fonctionnelle des génomes ancestraux de vertébrés par duplication de gènes. Résumé Létude scientifique des processus biologiques sappuie généralement sur lobservation de résultats expérimentaux réalisés sur des modèles vivants. Cette évidence masque le fait que lensemble des organismes vivants est le fruit de centaines de millions dannées dévolution qui elles sont inaccessibles aux expériences, car situées dans le passé. Pour contribuer à rendre à la biologie cette dimension historique, notre laboratoire a entrepris de reconstruire une succession de génomes ancestraux, chez les vertébrés. Ici, nous exploitons à grande échelle les reconstitutions de génomes de vertébrés, afin de mettre en évidence, quantifier et dater les duplications de gènes au sein de différentes lignées de vertébrés. Ces duplications, en autorisant un relachement de la pression de sélection, ...
Genus Alpharetrovirus; type species: Avian leukosis virus; others include Rous sarcoma virus ... Genus Betaretrovirus; type species: Mouse mammary tumour virus. *Genus Gammaretrovirus; type species: Murine leukemia virus; ... "Virus Taxonomy: 2018b Release" (html). International Committee on Taxonomy of Viruses (ICTV). March 2019. Retrieved 16 March ... Group VII viruses[edit]. Both families in Group VII have DNA genomes contained within the invading virus particles. The DNA ...
Lymphoid leukosis Avian sarcoma leukosis virus Marek's disease Gallid alphaherpesvirus 2 Moniliasis yeast infection. or thrush ... Briskie, J. V.; R. Montgomerie (1997). "Sexual Selection and the Intromittent Organ of Birds". Journal of Avian Biology. 28 (1 ... functional reference in an avian vocal system". Animal Behaviour. 46 (1): 23-38. doi:10.1006/anbe.1993.1158. S2CID 53165305.. ... "An Animal Model of Varicella Virus Infection". Brain Pathology. 11 (4): 475-479. doi:10.1111/j.1750-3639.2001.tb00416.x. PMC ...
Rubin, H; Vogt PK (1962). "An avian leukosis virus associated with stocks of Rous sarcoma virus". Virology. 17: 184-94. doi: ... Vogt, PK; Ishizaki R (1966). Burdette, WJ (ed.). "Criteria for the classification of avian tumor viruses". Viruses Inducing ... Maki, Y; Bos TJ; Davis C; Starbuck M; Vogt PK (1987). "Avian sarcoma virus 17 carries the jun oncogene". Proc Natl Acad Sci U S ... "Nobel Prize 1989". Duesberg, PH; Bister K; Vogt PK (1977). "The RNA of avian acute leukemia virus MC29". Proc Natl Acad Sci U S ...
Lymphoid Leukosis A, B; Avian Lymphoid Leukosis Virus; Lymphoid Leukosis Viruses A,B,C,D,E,J; Marek's Disease (Serotypes 1,2, 3 ... Avian Nephritis Virus, Avian Paramyxovirus Type 2, Avian Reovirus S 1133, Avian Rhinotracheitis Virus; Avian Rotavirus; Avian ... Avian Adenovirus Group II (HEV), Avian Adenovirus Group III (EDS), Avian Encephalomyelitis, Avian Influenza (Type A), ... For SPF eggs the specific pathogens are: Avian Adenovirus Group I, ...
Species include the Rous sarcoma virus, avian leukosis virus, and avian myeloblastosis virus. Not all animals that can infect ... The tumor caused by the virus is usually in the form of lymphoma and leukemia. It occurs after a long and latent process. The ...
... caused by the retrovirus Avian leukosis virus. It is a neoplastic disease caused by a virus, which may take the form of a tumor ... "The Poultry Guide - Avian Lymphoid Leukosis". Archived from the original on 2017-12-11. Retrieved 2007-12-12. v t e. ...
Curristin SM, Bird KJ, Tubbs RJ, Ruddell A (1997). "VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced ...
Rous sarcoma and Avian leukosis viruses (Alpharetroviruses and Avian type C retroviruses). dr1 is required for efficient viral ... Aschoff JM, Foster D, Coffin JM (September 1999). "Point mutations in the avian sarcoma/leukosis virus 3' untranslated region ... The direct repeat 1 (dr1) element is an RNA element commonly found in the 3' UTR of Avian sarcoma, ...
Her initial focus used the avian sarcoma leukosis viruses (ASV) of chickens as a model system. With Bill McClements and others ... including the AIDS virus) replicate and insert their genetic material into the host genome." She was elected to the American ... the laboratory cloned part of the avian endogenous provirus ev-1 as well as its integration site; the results suggested ...
Avian leukosis virus is an example of a virus that causes a disease by insertional mutagenesis. Newly hatched chicks infected ... with Avian leukosis virus will begin to form tumours that will begin to appear in their bursa of fabricus (like the human ... The virus inserts a gene (known as a viral oncogene) normally near the cellular myc (c-myc)gene. The c-myc gene is normally ... Because many viruses integrate their own genomes into the genomes of their host cells in order to replicate, mutagenesis caused ...
KOREC, E., & HLOŽÁNEK, I. Detection of avian leukosis virus group-specific antigens in feather pulp of chickens by Elisa. Folia ... with a doctoral thesis on the Expression and Detection of Virus Proteins of Tumor Viruses. After 1986, Korec completed long- ... ISBN 978-80-906605-1-9. KOREC, E., & HLOŽÁNEK, I. Susceptibility of the Minor line of inbred hens to the Rous sarcoma virus ... KOREC, E., HLOŽÁNEK, I., & BENDA, V. A rapid detection of avian oncovirus group-specific antigens in feather pulp by the enzyme ...
The Env proteins of the Avian Sarcoma and Leukosis virus (ASLV) and the Murine Leukemia Virus (MLV) are both trimers of SU-TM ... Avian Sarcoma and Leukosis Viruses (ASLV) have ten subgroups (A through J). The envelope glycoprotein of subgroup A is called ... Balliet JW, Gendron K, Bates P (April 2000). "Mutational analysis of the subgroup A avian sarcoma and leukosis virus putative ... "Low pH is required for avian sarcoma and leukosis virus Env-dependent viral penetration into the cytosol and not for viral ...
... for instance between Avian sarcoma leukosis virus and Marek's disease virus (MDV) in domestic fowl.[citation needed] Both ... In coinfected cells, the retroviral DNA of the avian leukosis virus can integrate into the MDV genome, producing altered ... The drop in HIV virus levels may be due to a lack of target CD4+ T cells in which they replicate, or measles virus may ... "Hepatitis B virus infection among American patients with chronic hepatitis C virus infection: Prevalence, racial/ethnic ...
... horses Leucosis in sheep Feline leucosis Feline leukemia virus Avian leucosis and related diseases Avian sarcoma leukosis virus ... ISBN 0-7020-0718-8. H. Graham Purchase and L.N. Payne, Leukosis/sarcoma Group, in Diseases of poultry, ed. by M.S. Hofstad, ... Bovine leucosis Enzootic bovine leucosis, caused by bovine leukemia virus. Sporadic bovine leucosis Calf lymphosarcoma Leucosis ... "Bovine leukemia virus". The dictionary of virology (4th ed.). Amsterdam: Elsevier/Academic Press. pp. 61-62. ISBN 9780080920368 ...
American Literary Version Avian leukosis virus Autoliv (ticker symbol) This disambiguation page lists articles associated with ...
Viruses portal Avian sarcoma leukosis virus (ASLV) Endogenous viral element ERV3 HERV-FRD Horizontal gene transfer Jaagsiekte ... Murine leukemia virus (MLV) and xenotropic murine leukemia virus-related virus (XMRV) Paleovirology Belshaw R, Pereira V, ... Yolken R (June 2004). "Viruses and schizophrenia: a focus on herpes simplex virus". Herpes. 11 (Suppl 2): 83A-88A. PMID ... "Reactivated Virus May Contribute to ALS". 2016-01-23. Karamitros T, Hurst T, Marchi E, Karamichali E, Georgopoulou U, Mentis A ...
... virus Infectious bursal disease also known as IBD or Gumboro disease Lymphoid leukosis caused by avian sarcoma leukosis virus ... caused by Histomonas meleagridis Coccidiosis Ergotism Aspergillosis Sour crop Ringworm Avian Influenza Fowl Pox Gallid or Avian ... Marek's disease Newcastle disease Viral arthritis Avian influenza Fowl pox Epidemic tremor Avian laryngotracheitis Scaly leg, ... Gumboro Lymphoid Leukosis Marek's Disease Newcastle Disease Poultry. ...
Genus Alpharetrovirus; type species: Avian leukosis virus; others include Rous sarcoma virus ... Such viruses are either single stranded RNA (e.g. HIV) or double stranded DNA (e.g. Hepatitis B virus) viruses. ... Genus Betaretrovirus; type species: Mouse mammary tumour virus. *Genus Gammaretrovirus; type species: Murine leukemia virus; ... "Virus Taxonomy: 2018b Release" (html). International Committee on Taxonomy of Viruses (ICTV). March 2019. Retrieved 16 March ...
... after Marek's disease and avian leukosis virus. The various syndromes caused by REV resemble both Marek's and avian leukosis. ... Reticuloendotheliosis virus represents a third distinct etiological group of avian viral neoplasms, ... MI is the primary laboratory for research in REV and other tumor viruses. The American Association of Avian Pathologists ... Reticuloendotheliosis (RE) designates a group of pathologic syndromes caused by the reticuloendotheliosis virus (REV) group of ...
1908: Vilhelm Ellerman and Olaf Bang, University of Copenhagen, first demonstrated that avian sarcoma leukosis virus could be ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... RNA viruses[edit]. Not all oncoviruses are DNA viruses. Some RNA viruses have also been associated such as the hepatitis C ... DNA viruses[edit]. *Human papilloma virus (HPV), a DNA virus, causes transformation in cells through interfering with tumor ...
Ancient DNA Avian sarcoma leukosis virus (ASLV) Endogenous retrovirus ERV3 HERV-FRD Jaagsiekte sheep retrovirus (JSRV) Koala ... Murine leukemia virus (MLV), and xenotropic murine leukemia virus-related virus (XMRV) Paleovirology Polydnavirus Viral ... An endogenous viral element (EVE) is a DNA sequence derived from a virus, and present within the germline of a non-viral ... For most non-retroviral viruses, germline integration appears to be a rare, anomalous event, and the resulting EVEs are often ...
... avian MeSH C04.619.857.822 - sarcoma, yoshida MeSH C04.619.935.120 - avian leukosis MeSH C04.619.935.313 - epstein-barr virus ... enzootic bovine leukosis MeSH C04.557.337.372 - leukemia, experimental MeSH C04.557.337.372.216 - avian leukosis MeSH C04.557. ... avian leukosis MeSH C04.619.531.594 - leukemia L1210 MeSH C04.619.531.602 - leukemia L5178 MeSH C04.619.531.782 - leukemia p388 ... avian MeSH C04.651.600.500 - multiple endocrine neoplasia type 1 MeSH C04.651.600.505 - multiple endocrine neoplasia type 2a ...
The most common immunosuppressive viruses are Infectious Bursal Disease Virus (IBDV), Avian Leukosis, Marek's Disease (MD) and ... "Development of the Avian Immune System." Avian Immunology. 4:51-66. Masteller EL, Pharr GT, Funk PE, Thompson CB (1997). "Avian ... Infectious bursal disease virus and chicken anemia are ubiquitous and have increased interest in combatting avian pathogens. ... Jenkins KA, Bean AG, Lowenthal JW (2007). "Avian genomics and the innate immune response to viruses." Cytogenet. Genome Res. ...
Bang and Ellerman demonstrated that avian sarcoma leukosis virus could be transmitted between chickens after cell-free ... Tumor viruses come in a variety of forms: Viruses with a DNA genome, such as adenovirus, and viruses with an RNA genome, like ... Not all oncoviruses are DNA viruses. Some RNA viruses have also been associated such as the hepatitis C virus as well as ... Human T-lymphotropic virus and hepatitis B virus, which normally replicates as a mixed double and single-stranded DNA virus but ...
"Avian sarcoma and leukosis virus-receptor interactions: from classical genetics to novel insights into virus-cell membrane ... Avian sarcoma leukosis virus is characterized by a wide range of tumors, the most common of which are lymphomas. Lymphoid ... Avian sarcoma leukosis virus (ASLV) is an endogenous retrovirus that infects and can lead to cancer in chickens; experimentally ... ISBN 978-1-118-71973-2. Riddell, C. (May-June 1999). "The current problem with Avian Leukosis J Virus". California Poultry ...
Family 1.G.12 The Avian Leukosis Virus gp95 Fusion Protein (ALV-gp95) Family 1.G.13 The Orthoreovirus Fusion-associated Small ... 1.A.39 Type C influenza virus CM2 channel family 1.A.40 Human immunodeficiency virus type I Vpu channel family 1.A.41 Avian ... 1.A.58 The Type B Influenza Virus Matrix Protein 2 (BM2-C) Family 1.A.59 The Bursal Disease Virus Pore-Forming Peptide, Pep46 ( ... Family 1.G.16 The Human Immunodeficiency Virus Type 1 (HIV-1) Fusion Peptide (HIV-FP) Family 1.G.17 The Bovine Leukemia Virus ...
Avian infectious laryngotracheitis. *Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis (blackhead disease) ...
Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis (blackhead disease). *Botulism. *Campylobacteriosis. * ...
ssRNA-RT virus. Retroviridae. Alpharetrovirus. *Avian sarcoma leukosis virus. *Rous sarcoma virus ... dsDNA-RT viruses are the seventh group in the Baltimore virus classification. They are not considered DNA viruses (class I of ... Khan, Jawaid A.; Dijkstra, Jeanne (2002). Plant viruses as molecular pathogens. Psychology Press. pp. 317-. ISBN 978-1-56022- ... Retrieved from "https://en.wikipedia.org/w/index.php?title=DsDNA-RT_virus&oldid=748922731" ...
Talk:Avian reovirus. *Talk:Avian reovirus (version 2). *Talk:Avian sarcoma leukosis virus ... Pages in category "Low-importance virus articles". The following 200 pages are in this category, out of approximately 1,493 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:Low-importance_virus_articles&oldid=388350164" ...
Avian infectious laryngotracheitis. *Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis (blackhead disease) ... Further information: Influenza A virus subtype H7N9. Influenza A virus subtype H7N9 is a novel avian influenza virus first ... Avian influenza, known informally as avian flu or bird flu, is a variety of influenza caused by viruses adapted to birds.[1][2] ... Until H5N1, all known avian influenza viruses had a Glu at position 627, while all human influenza viruses had a Lys.[15]. HA ...
ssRNA-RT virus. Retroviridae. Alpharetrovirus. *Avian sarcoma leukosis virus. *Rous sarcoma virus ... এইচ.আই.ভি. (ইংরেজি: HIV; পূর্ণরূপ: Human Immunodeficiency Virus হিউম্যান ইমিউনো ডেফিশিয়েন্সি ভাইরাস) বা মানব প্রতিরক্ষা ... Reeves, J. D. and Doms, R. W (২০০২)। "Human Immunodeficiency Virus Type 2"। J. Gen. Virol.। 83 (Pt 6): 1253-65। ডিওআই:10.1099/ ... International Committee on Taxonomy of Viruses। "61. Retroviridae"। National Institutes of Health। সংগ্রহের তারিখ ২০০৬-০২-২৮।. ...
ssRNA-RT virus. Retroviridae. Alpharetrovirus. *Avian sarcoma leukosis virus. *Rous sarcoma virus ... Xenotropic Murine Leukemia Virus-Related Virus: Classification[citation needed] Xenotropic viruses (xenos Gr. foreign; tropos ... Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus which was first described in 2006 as an apparently novel ... "XMRV (Xenotropic Murine Leukemia Virus-related Virus) , CDC". www.cdc.gov. Retrieved 2018-04-17.. .mw-parser-output cite. ...
Avian influenza. *Avian sarcoma leukosis virus. *Histomoniasis (blackhead disease). *Botulism. *Campylobacteriosis. * ... Avian Biology Research, 1: 73-87 *^ Dixon, L.M., Duncan, I.J.H. and Mason, G.J., 2010. The effects of four types of enrichment ... G., (2010). Avian magnetoreception: Elaborate iron mineral containing dendrites in the upper beak seem to be a common feature ...
ssRNA-RT virus. Retroviridae. Alpharetrovirus. *Avian sarcoma leukosis virus. *Rous sarcoma virus ... Caprine arthritis encephalitis virus. Visna/maedi virus. Primate lentivirus group. Human immunodeficiency virus 1. Human ... Bovine immunodeficiency virus. Jembrana disease virus. Equine lentivirus group. Equine infectious anemia virus. Feline ... Simian immunodeficiency virus. Gray mouse lemur prosimian immunodeficiency virus (pSIVgml). Lentivirus (lente-, Latin for "slow ...
... leukosis virus, avian MeSH B04.820.650.070.550 - myeloblastosis virus, avian MeSH B04.820.650.070.775 - sarcoma viruses, avian ... avian MeSH B04.909.574.807.070.500 - leukosis virus, avian MeSH B04.909.574.807.070.550 - myeloblastosis virus, avian MeSH ... avian MeSH B04.909.777.731.070.500 - leukosis virus, avian MeSH B04.909.777.731.070.550 - myeloblastosis virus, avian MeSH ... encephalomyelitis virus, avian MeSH B04.820.565.400.410 - hepatitis a virus MeSH B04.820.565.400.410.500 - hepatitis a virus, ...
It is not uncommon that more than one avian tumor virus can be present in a chicken, thus one must consider both the diagnosis ... The lymphomatous infiltrates need to be differentiated from other conditions that affect poultry including lymphoid leukosis ... One vaccine in particular is the vaccine for avian influenza. Leaky vaccine use for avian influenza can select for virulent ... standard and quantitative PCR for identification of the virus, virus isolation to confirm infections, and serology to confirm/ ...
... avian leukosis MeSH C22.131.321 - fowlpox MeSH C22.131.450 - influenza in birds MeSH C22.131.498 - malaria, avian MeSH C22.131. ... marburg virus disease MeSH C22.735.500.850 - simian acquired immunodeficiency syndrome MeSH C22.735.750 - monkeypox MeSH ... avian MeSH C22.131.921 - tuberculosis, avian MeSH C22.180.350 - feline acquired immunodeficiency syndrome MeSH C22.180.440 - ... enzootic bovine leukosis MeSH C22.196.274 - ephemeral fever MeSH C22.196.339 - freemartinism MeSH C22.196.400 - hemorrhagic ...
"Avian sarcoma and leukosis virus-receptor interactions: from classical genetics to novel insights into virus-cell membrane ... Avian sarcoma leukosis virus is characterized by a wide range of tumors, the most common of which are lymphomas. Lymphoid ... Avian sarcoma leukosis virus (ASLV) is an endogenous retrovirus that infects and can lead to cancer in chickens; experimentally ... ISBN 978-1-118-71973-2. Riddell, C. (May-June 1999). "The current problem with Avian Leukosis J Virus". California Poultry ...
Identification of a cellular receptor for subgroup E avian leukosis virus. Heather B. Adkins, Jürgen Brojatsch, John Naughton, ... Identification of a cellular receptor for subgroup E avian leukosis virus. Heather B. Adkins, Jürgen Brojatsch, John Naughton, ... Identification of a cellular receptor for subgroup E avian leukosis virus. Heather B. Adkins, Jürgen Brojatsch, John Naughton, ... Identification of a cellular receptor for subgroup E avian leukosis virus Message Subject (Your Name) has sent you a message ...
Problem Substances : Avian Leukosis Viruses (ALV-E), Endogenous avian retrovirus (EAV-0) ... 1 Abstracts with Avian Leukosis Viruses (ALV-E) Research. Filter by Study Type. Viral. ... Characterization of endogenous avian leukosis viruses in chicken embryonic fibroblast substrates used in production of measles ... Additional Keywords : Adventitious Viruses, Live Attenuated Vaccines, Vaccine Contamination. ...
The mechanism of interference between an avian leukosis virus and Rous sarcoma virus. II. Early steps of infection by RSV of ...
Recovery of acutely transforming viruses from myeloid leukosis induced by the HPRS-103 strain of avian leukosis virus. Avian ... Occurrence of avian leukosis virus subgroup J in commercial layer flocks in China. Avian Pathol. 2004;33:13-7. DOIPubMed ... tests for the detection of subgroup J avian leukosis virus. Virus Res. 1998;54:87-98. DOIPubMed ... Emerging of avian leukosis virus subgroup J in a flock of Chinese local breed [in Chinese]. Acta Microbiol Sin. 2005;45:584-7. ...
Identification and characterisation of endogenous Avian Leukosis Virus subgroup E (ALVE) insertions in chicken whole genome ... Molecular identification of avian leukosis virus subgroup E loci and tumor virus B locus in Chinese indigenous chickens. ... In chickens, endogenous Avian Leukosis Virus subgroup E (ALVE) expression has been associated with reductions in muscle growth ... In chickens, endogenous Avian Leukosis Virus subgroup E (ALVE) expression has been associated with reductions in muscle growth ...
Occupational exposure to poultry and prevalence of antibodies against Mareks disease virus and avian leukosis retroviruses. ... Occupational exposure to poultry and prevalence of antibodies against Mareks disease virus and avian leukosis retroviruses. ... Occupational exposure to poultry and prevalence of antibodies against Mareks disease virus and avian leukosis retroviruses. ...
Virus-Cell Interactions. Integration Targeting by Avian Sarcoma-Leukosis Virus and Human Immunodeficiency Virus in the Chicken ... Integration Targeting by Avian Sarcoma-Leukosis Virus and Human Immunodeficiency Virus in the Chicken Genome ... Integration Targeting by Avian Sarcoma-Leukosis Virus and Human Immunodeficiency Virus in the Chicken Genome ... Integration Targeting by Avian Sarcoma-Leukosis Virus and Human Immunodeficiency Virus in the Chicken Genome ...
Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events.. B E Clurman ... Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events. ... Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events. ... Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events. ...
"Isolation and characterization of subgroup J Avian Leukosis virus associated with hemangioma in commercial Hy-Line chickens, ... Occurrence of avian leukosis virus subgroup J in commercial layer flocks in China . Avian Pathol. 33 : 13 - 17 . Google Scholar ... Occurrence of avian leukosis virus subgroup J in commercial layer flocks in China . Avian Pathol. 33 : 13 - 17 . Google Scholar ... Avian sarcoma and leukosis virus-receptor interactions: from classical genetics to novel insights into virus-cell membrane ...
"Identification of a linear B-cell epitope on the avian leukosis virus P27 protein using monoclonal antibodies, Archives of ... Recovery of acutely transforming viruses from myeloid leukosis induced by the HPRS-103 strain of avian leukosis virus ... Avian leukosis virus (ALV) is an avian oncogenic retrovirus that can induce various clinical tumors. The capsid protein P27 is ... Isolation and some characteristics of a subgroup J-like avian leukosis virus associated with myeloid leukosis in meat-type ...
The results verify that the LAMP method was more sensitive than the conventional PCR and virus isolation method. In conclusion ... assay were developed and compared with PCR and virus isolation methods. The results from specificity of the LAMP assay showed ... E and J are the major subgroups of avian leukosis virus (ALV) infecting chickens. ALV infection has become endemic in China and ... Avian Pathol. 2009;38(6):443-8.Google Scholar. *. Zavala G, Cheng S. Detection and characterization of avian leukosis virus in ...
Structural dynamics and local changes in the dimerization site of avian retroviral RNA were studied. Our task was to identify ... To this end we replaced the unpaired adenine in the hairpin loop of avian leukosis virus RNA with a fluorescent probe 2- ... Conformation Change of the Loop Adenine of Avian Leukosis Virus RNA Upon Antibiotic Binding Revealed by 2-Aminopurine ... Structural dynamics and local changes in the dimerization site of avian retroviral RNA were studied. Our task was to identify ...
Recently, we have isolated several viruses related to HPRS-103 from cases of ML. Although these isolates showed properties of ... The nucleotide sequence of the env gene of the variant viruses showed several substitutions resulting in amino acid changes ... The epidemiological significance of the antigenic variation and the emergence of variant viruses are discussed. ... was isolated in 1989 from meat-type chickens from commercial flocks where it induces myelocytic myeloid leukosis (ML). The HPRS ...
Receptor specificity in avian sarcoma and leukosis viruses (ASLV) maps to the central region of the envelope surface protein, ... of the ASLV envelope sequences revealed a cluster of basic residues within hr2 that is unique to the subgroup A viruses, ... Receptor-induced conformational changes in the subgroup A avian leukosis and sarcoma virus envelope glycoprotein.. *J M Gilbert ... Receptor specificity in avian sarcoma and leukosis viruses (ASLV) maps to the central region of the envelope surface protein, ...
The result showed that the mRNA level of chNHE1 was up-regulated after virus shedding, especially in continuous viremic ... Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus which causes immunosuppression and neoplasia in meat-type ... From: Avian leukosis virus subgroup J induces its receptor--chNHE1 up-regulation ...
Although there are seven different subgroups of the virus (A through J), subgroup J is the most significant cause of outbreaks ... Avian leukosis virus (ALV) is a retrovirus which causes the development of several different kinds of benign and malignant ... Avian leukosis virus. Avian leukosis virus (ALV) is a retrovirus which causes the development of several different kinds of ... Lymphoid leukosis: Lymphoid leukosis is caused by an avian retrovirus that induces a lymphoblastic lymphosarcoma in susceptible ...
Actually, endogenous avian sarcoma and leukosis virus (enASLV) sequences are variable in the Galliformes birds, and geese have ... Reply to commentary by D. Elleder and J. Hejnar on the article "Avian sarcoma and leukosis virus gag gene in the Anser anser ... Actually, endogenous avian sarcoma and leukosis virus (enASLV) sequences are variable in the Galliformes birds, and geese have ... Actually, endogenous avian sarcoma and leukosis virus (enASLV) sequences are variable in the Galliformes birds, and geese have ...
... following eradication of the virus,commercial broilers have remained free of infection since the early 2000s. A pet chicken was ... The avian leukosis viruses (ALVs) are a major group of retroviruses associated with neoplastic diseases in poultry. The ALV-J ... Avian leukosis virus subgroup J-associated myelocytoma in a hobby chicken. The avian leukosis viruses (ALVs) are a major group ... Home » Publications » Avian leukosis virus subgroup J-associated myelocytoma in a hobby chicken ...
This research includes tissue tropism of avian leukosis virus subgroup J (ALV-J) in congenitally infected broiler chickens ... and the antiserum produced had in vitro neutralizing activity against the cloned virus. The cloned virus was then serially ... In a second experiment, chickens were exposed to ALV-J by injection of virus at hatch. Injection of ALV-J antiserum protected ... In one experiment, chickens exposed to ALV-J by cohatching with virus-shedders did not suffer from body weight suppression or ...
Avian Leukosis Virus, ALV, infectious poultry disease, chicken diseases, Chicken health, laying hens disease, white chicken, ... Avian Leukosis Virus (ALV) in Laying hens. Avian leukosis virus (ALV) is an oncogenic virus, an infectious disease causing ... Exogenous leukosis viruses are transmitted as infectious virus particles. Exogenous ALVs are transmitted vertically from hen ... Endogenous leukosis viruses are part of the chicken genome and are transmitted genetically. Some can be expressed in an ...
Twenty-eight broiler breeder flocks were tested for avian leukosi ... Incidence of avian leukosis virus infection in broiler stocks ... Incidence of avian leukosis virus infection in broiler stocks and its effect on early growth.. Authors * Crittenden, L B ... Twenty-eight broiler breeder flocks were tested for avian leukosis virus (ALV) group-specific (gs) antigen shedding into the ... Progeny of positive dams or chicks having virus in their meconia weighed 1 to 3% less at 4 and 7 weeks than progeny of negative ...
Avian Leukosis Virus. Avian leukosis virus (ALV) belongs to the genus Alpharetrovirus of the Retroviridae family. This virus is ... influenza A virus (IAV); infectious bursal disease virus (IBDV); Mareks disease virus (MDV); avian leukosis virus (ALV); ... Role of gga-miR-221 and gga-miR-222 during tumour formation in chickens infected by subgroup J avian leukosis virus. Viruses ( ... Aberrant expression of liver microRNA in chickens infected with subgroup J avian leukosis virus. Virus Res (2012) 169(1):268-71 ...
PMCID: PMC112645 Evidence of Avian Leukosis Virus Subgroup E and Endogenous Avian Virus in Measles and Mumps Vaccines Derived ... Evidence of Avian Leukosis Virus Subgroup E and Endogenous Avian Virus in Measles and Mumps Vaccines Derived from Chicken Cells ... Vaccine Contamination with other viruses - Avian Leukosis Virus. May 5, 2015. Vaccine 0 Comments ... Lack of evidence of endogenous avian leukosis virus and endogenous avian retrovirus transmission to measles, mumps, and rubella ...
The Avian Leukosis Virus p27 Antigen test kit will determine the presence of the p27 antigen of the Avian Leukosis Virus in ... To detect antigen (P27) of Avian Leukosis Virus. Kit format:. Plates per kit: 5. Maximum sample size: 460. Run at room ... A highly specific ELISA for detection of Avian Leukosis Virus antigen, used in eradication programs. ... The Avian Leukosis Virus Antigen test kit is used for:. *Screening flocks for presence or absence of Avian Leukosis Virus ...
An NF-κB-dependent survival pathway protects against cell death induced by TVB receptors for avian leukosis viruses. ... An NF-κB-dependent survival pathway protects against cell death induced by TVB receptors for avian leukosis viruses. Together ...
Cross-species Transmission of Avian Leukosis Virus Subgroup J Cross-species Transmission of Avian Leukosis Virus Subgroup J / 病 ... Amino Acid Sequence , Animals , Avian Leukosis , Virology , Avian Leukosis Virus , Classification , Genetics , Physiology , ... Avian leukosis virus subgroup J (ALV-J) is an avian retrovirus that can induce myelocytomas. A high-frequency mutation in gene ... Avian Leukosis / Molecular Sequence Data / Chemistry / Chickens / Viral Envelope Proteins Language: Chinese Journal: Chinese ...
... negative chickens exposed to virus at hatching. , Avian diseases , 7/27/1988 ... Avian leukosis virus (ALV) infection, shedding, and tumors in maternal ALV antibody-positive and - ... Avian Dis. 1988;32(1):89-95. Chickens highly susceptible to avian leukosis virus (ALV) infection and tumors, with and without ... Avian diseases PubMedID: 2838017. Fadly AM. Avian leukosis virus (ALV) infection, shedding, and tumors in maternal ALV antibody ...
Avian sarcoma leukosis virus (ASLV) is an endogenous retrovirus that infects and can lead to cancer in chickens; experimentally ... This Anti avian leukosis virus P27 protein monoclonal antibody is used in immunoassays to detect ALV specificly. ... Subgroups A, B, E and J are the major subgroups of avian leukosis virus (ALV) infecting chickens. ALV infection has become ... Anti avian leukosis virus P27 protein monoclonal antibody / clone # 5E1-1F1. $400.00. ...
Avian sarcoma leukosis virus ~~~ Title: What is Avian sarcoma leukosis virus?, Explain Avian sarcoma leukosis virus Created on ... What is Avian sarcoma leukosis virus?, Explain Avian sarcoma leukosis virus. by admin · April 14, 2019. ...
  • Further evidence that these viruses use the same or related receptors comes from genetic studies in chickens which indicated that several alleles of a single locus, tv-b , encode receptors for subgroups B, D, and E viruses ( 1 , 3 , 4 ). (pnas.org)
  • In recent years, cases of avian leukosis virus subgroup J (ALV-J) infection and tumors in commercial layer chickens and breeders of egg-type chickens have been emerging in the People's Republic of China. (cdc.gov)
  • ALV-J was first isolated from meat-type chickens with myeloid leukosis in 1988. (cdc.gov)
  • In chickens, endogenous Avian Leukosis Virus subgroup E (ALVE) expression has been associated with reductions in muscle growth rate and egg production, as well as providing the potential for novel recombinant viruses. (unboundmedicine.com)
  • In chickens, however, there is a large class of endogenous retroviruses, members of the ERVK group, that are related to the replication-competent avian sarcoma-leukosis viruses (ASLV). (asm.org)
  • Meng, Fanfeng;Li, Qiuchen;Zhang, Yubiao;Cui, Zhizhong;Chang, Shuang;Zhao, Peng 2018-07-11 00:00:00 Abstract There was an outbreak of hemangioma associated with avian leukosis virus subgroup J (ALV-J) between 2006 and 2010 in China in commercial layer chickens. (deepdyve.com)
  • Virus Isolation Blood samples were collected aseptically from the infected Hy-Line brown layer chickens with suspected hemangioma, and all blood samples were centrifuged at 2,000 revolutions per minute for 2 min at 4°C to obtain plasma for virus isolation. (deepdyve.com)
  • Subgroups A, B, E and J are the major subgroups of avian leukosis virus (ALV) infecting chickens. (biomedcentral.com)
  • Avian leukosis virus (ALV) is an economically important poultry pathogen and its infection may result in low productivity and tumor mortality in chickens. (biomedcentral.com)
  • HPRS-103, the prototype of avian leukosis virus (ALV) subgroup J, was isolated in 1989 from meat-type chickens from commercial flocks where it induces myelocytic myeloid leukosis (ML). The HPRS-103 env gene differs considerably from other ALV subgroups but shows high identity (75-97%) to env-like sequences of the different members of the EAV family of endogenous avian retroviruses. (microbiologyresearch.org)
  • Avian leukosis virus (ALV) is a retrovirus which causes the development of several different kinds of benign and malignant neoplasms (tumors) in chickens worldwide. (poultrydvm.com)
  • Lymphoid leukosis is caused by an avian retrovirus that induces a lymphoblastic lymphosarcoma in susceptible chickens, four months of age or older. (poultrydvm.com)
  • Since ALV is widespread among chickens, virus isolation and the demonstration of antigen or antibody have limited or no value in diagnosing field cases of lymphomas. (poultrydvm.com)
  • Chickens can also become infected by receiving the Marek's disease virus vaccine or fowl pox vaccine, which are frequently contaminated. (poultrydvm.com)
  • Virus was not detected in blood samples in the other five chickens remaining in the flock. (pirbright.ac.uk)
  • This research includes tissue tropism of avian leukosis virus subgroup J (ALV-J) in congenitally infected broiler chickens using an immunohistochemistry (IHC) technique detecting gp85 viral glycoprotein. (uga.edu)
  • The cloned virus was injected into specific pathogen free (SPF) chickens, and the antiserum produced had in vitro neutralizing activity against the cloned virus. (uga.edu)
  • In one experiment, chickens exposed to ALV-J by cohatching with virus-shedders did not suffer from body weight suppression or ALV related tumors, and the injected ALV-J antiserum did not protect against development of viremia or increase the number of chickens subsequently developing active immunity. (uga.edu)
  • In a second experiment, chickens were exposed to ALV-J by injection of virus at hatch. (uga.edu)
  • Injection of ALV-J antiserum protected these chickens against development of ALV-J related tumors, but did not protect against virus induced body weight suppression or development of viremia, and did not increase the number of chickens developing active immunity. (uga.edu)
  • Chickens below the age of 4 weeks do not develop immune responses to the virus. (hendrix-genetics.com)
  • The Avian Leukosis Virus p27 Antigen test kit will determine the presence of the p27 antigen of the Avian Leukosis Virus in chickens. (biochek.com)
  • Avian leukosis virus (ALV) infection, shedding, and tumors in maternal ALV antibody-positive and -negative chickens exposed to virus at hatching. (docphin.com)
  • Chickens highly susceptible to avian leukosis virus (ALV) infection and tumors, with and without ALV subgroup A maternal antibody (MAB), were infected with a field strain of ALV subgroup A at hatching. (docphin.com)
  • As the virus develops along with the cells of the embryo , chickens hatching from these eggs will not be able to differentiate the virus from their own cells. (everything2.com)
  • Multicentric histiocytosis related to avian leukosis virus subgroup J (ALV-J)-infection in meat-type local chickens. (omicsdi.org)
  • Avian leukosis virus subgroup J (ALV-J) was first isolated from meat-type chickens in 1988. (omicsdi.org)
  • Avian leukosis virus (ALV) is an oncogenic virus causing a variety of neoplasms in chickens. (usda.gov)
  • The group of avian leukosis virus in chickens contains six closely related subgroups, A to E and J. The prevalence of ALVs in hosts may have imposed strong selection pressure toward resistance to ALV infection, and chickens have evolved resistance to infection by the ALVs. (usda.gov)
  • Methods: 140-day-old female chickens of White Recessive Rock (WRR) were confirmed as J subgroup avian leukosis virus (ALV-J) infection. (omicsdi.org)
  • The E26 avian retrovirus causes an acute leukemia in chickens and transforms both myeloid and erythroid cells. (nih.gov)
  • Induction of lymphomas in the bursa of Fabricius of chickens by replication competent, non-transforming avian retroviruses (Avian Leukosis Virus, ALV) is both an economically significant, naturally occurring disease and an experimental model system which has provided seminal insights into the role of the myc oncogene in B-cell neoplasia. (springer.com)
  • Enrietto PJ, Payne LN, Hayman MJ (1983) A recovered avian myelocytomatosis virus that induces lymphomas in chickens: Pathogenic properties and their molecular basis. (springer.com)
  • 3. Infectious virus neutralizing antibody and tumors in chickens innoculated at various ages. (springer.com)
  • Under natural conditions, lymphoid leukosis has been the most common form of the leukosis/sarcoma group of diseases seen in chicken flocks, although in the 1990s myeloid leukosis become prevalent in meat-type chickens. (merckvetmanual.com)
  • Lymphoid leukosis occurs naturally only in chickens. (merckvetmanual.com)
  • Isolates that can induce lymphoid leukosis in chickens are commonly called avian leukosis viruses and are divided into subgroups A, B, C, D, and J, on the basis of differences in their viral envelope glycoproteins, which determine antigenicity, viral interference patterns with members of the same and different subgroups, and host range. (merckvetmanual.com)
  • Endogenous retrovirus (ERV) genomes integrated into the chromosomal DNA of the host were first detected in chickens and mice as Mendelian determinants of Gag and Env proteins and of the release of infectious virus particles. (royalsocietypublishing.org)
  • Geese not susceptible to virulent subgroup J avian leukosis virus isolated from chickens. (medworm.com)
  • Co-infections of chickens with Avian Influenza Virus H9N2 and Moroccan Italy 02 Infectious Bronchitis Virus: effect on pathogenesis and protection conferred by different vaccination programs. (medworm.com)
  • Comparative clinico-pathological assessment of velogenic (sub-genotype VIIi) and mesogenic (sub-genotype VIm) Avian avulavirus 1 in chickens and pigeons. (medworm.com)
  • Fowl pox is caused by a pox virus and mostly affects chickens. (poultrykeeper.com)
  • Osteopetrosis in chickens is due to infection with specific strains of avian leukosis/sarcoma virus . (merckvetmanual.com)
  • As with all retroviruses, the virus is transcribed from RNA to DNA, instead of DNA to RNA as in normal cellular replication. (wikipedia.org)
  • We are using avian leukosis virus (ALV) receptor interactions as a model system to understand how retroviruses enter their host cells. (pnas.org)
  • Occupational exposure to poultry and prevalence of antibodies against Marek's disease virus and avian leukosis retroviruses. (bmj.com)
  • We have analyzed the placement of sites of integration of avian sarcoma-leukosis virus (ASLV) and human immunodeficiency virus (HIV) DNA in the draft chicken genome sequence, with the goals of assessing species-specific effects on integration and allowing comparison to the distribution of chicken endogenous retroviruses (ERVs). (asm.org)
  • Phylogenetic analysis of the sequences showed the evolutionary relationships of the isolates with HPRS-103 and the EAV family of endogenous avian retroviruses. (microbiologyresearch.org)
  • The avian leukosis viruses (ALVs) are a major group of retroviruses associated with neoplastic diseases in poultry. (pirbright.ac.uk)
  • However, retroviruses function differently, as their RNA is reverse-transcribed into DNA, which is integrated into the host cell's genome (when it becomes a provirus ), and then undergoes the usual transcription and translational processes to express the genes carried by the virus. (wikipedia.org)
  • The U3 sequences of 84.2% (16/19) of the ALV-J layer isolates displayed less than 92.5% sequence homology to those of the ALV-J broiler isolates, although the transcriptional regulatory elements that are typical of avian retroviruses were highly conserved. (omicsdi.org)
  • Retroviruses are RNA-containing viruses that use the enzyme reverse transcriptase to copy their RNA into the DNA of a host cell. (encyclopedia.com)
  • Three genes are universally present in the genomes of retroviruses that are capable of replication, such as murine (mouse) leukemia virus. (encyclopedia.com)
  • An example of this is reticuloendotheliosis virus strain T. The genome of complex retroviruses, such as HTLV, can contain several other genes that regulate genome expression or replication and are not present in simple retroviruses. (encyclopedia.com)
  • Retroviruses follow the same general steps in their replication cycles that are common to other viruses. (encyclopedia.com)
  • Upon expression of TVA, these cells are capable of binding viruses with the envelope protein of avian sarcoma/leukosis virus subtype A ( ASLV-A ). These cTVA mice may be useful for infection by retroviruses, rabies virus, and other viruses with ASLV-A glycoproteins. (jax.org)
  • In his extensive studies on avian retroviruses, Vogt discovered oncogenes that play important roles in human cancers, e.g. myc (in collaboration with Bister and Duesberg), jun (with Maki and Bos) and p3k (with Chang). (wikipedia.org)
  • All examined retroviruses have been found to contain roughly 100 copies of Ub, and, with the exception of those in Rous sarcoma virus (RSV), about one-third of these molecules have been found to be individually conjugated to Gag at positions near the L domain ( 16 , 17 , 23 ). (asm.org)
  • Lymphoid leukosis is caused by certain members of the leukosis/sarcoma group of avian retroviruses. (merckvetmanual.com)
  • The entry process of the avian sarcoma and leukosis virus (ASLV) family of retroviruses requires first a specific interaction between the viral surface (SU) glycoproteins and a receptor on the cell surface at a neutral pH, triggering conformational changes in the viral SU and transmembrane (TM) glycoproteins, followed by exposure to low pH to complete fusion. (mendeley.com)
  • Conversely, many host genes have been incorporated into large DNA viruses, such as herpesviuses and poxviruses, as well as oncogene-bearing retroviruses. (royalsocietypublishing.org)
  • Endogenous genomes were first found in avian alpha-retroviruses, and soon after in murine beta- and gamma-retroviruses. (royalsocietypublishing.org)
  • There is little evidence yet of endogenous versions of delta-retroviruses related to human T-lymphotropic virus type 1 and bovine leukosis virus. (royalsocietypublishing.org)
  • Lymphomagenesis occurs because of the production of endogenous retroviruses ( 2 ) and the intrathymic injection of recombinant (thymotropic) murine leukemia virus accelerates the appearance of tumors ( 3 ). (jimmunol.org)
  • Avian leukosis virus belongs to a family of viruses called retroviruses. (poultrykeeper.com)
  • INTRODUCTION Avian leukosis virus (ALV) is an oncogenic retrovirus causing neoplastic diseases, such as lymphocytoma, myeloid leukosis, and hemangioma, as well as immunosuppression (Fadly and Smith, 1999). (deepdyve.com)
  • Myeloid leukosis diagnosed in a backyard flock, with ALV 'J strain' isolated. (thepoultrysite.com)
  • Since the initial isolation of subgroup J avian leukosis virus in England, the virus has been isolated from broiler-breeder stocks that experience myeloid neoplasms (myelocytoma) in many other countries. (merckvetmanual.com)
  • However, the movement was unsuccessful in maintaining leukosis-free flocks. (wikipedia.org)
  • Although there are seven different subgroups of the virus (A through J), subgroup J is the most significant cause of outbreaks among flocks. (poultrydvm.com)
  • Twenty-eight broiler breeder flocks were tested for avian leukosis virus (ALV) group-specific (gs) antigen shedding into the albumen. (mysciencework.com)
  • Approximately 25 per cent of Q3 avian diagnostic submissions were from game bird flocks and two-thirds from chicken flocks. (thepoultrysite.com)
  • Molecular epidemiology of avian leukosis virus subgroup J in layer flocks in China. (omicsdi.org)
  • However, layer flocks in China have experienced outbreaks of this virus in recent years. (omicsdi.org)
  • This research explores the possibility that hens infected with ALV-J through cock semen transmitted this virus to their offspring, and further clarifies the role of the cock on the infection and spread of ALV-J in chicken flocks. (beds.ac.uk)
  • Avian leukosis virus (ALV) is a retrovirus that causes tumors in avian species, and its vertical and horizontal transmission in poultry flocks results in enormous economic losses. (biomedcentral.com)
  • There is no treatment or vaccine available, so eradication of the virus from breeding flocks is the most effective control method. (merckvetmanual.com)
  • As much as 1.5% excess mortality per week has been reported in commercial broiler-breeder flocks naturally infected with subgroup J avian leukosis virus. (merckvetmanual.com)
  • Whilst we are all very familiar with Marek's disease causing tumours in chicken flocks, Avian Leukosis is another tumour causing virus that can have equally devastating effects. (poultrykeeper.com)
  • The subgroups evolved to utilize difference cellular receptors to gain entry into avian cells due to the host developing resistance to viral entry. (wikipedia.org)
  • Viral glycoprotein-receptor interactions are required to initiate membrane fusion of the virus and cell. (wikipedia.org)
  • Cells preinfected with either ALV-B or ALV-D are resistant to superinfection by subgroup B, D, and E viruses, presumably because of newly synthesized viral Env binding to the receptor, thus preventing subsequent rounds of viral entry ( 1 ). (pnas.org)
  • Analysis of the subgroup A avian sarcoma and leukosis virus receptor: the 40-residue, cysteine-rich, low-density lipoprotein receptor repeat motif of Tva is sufficient to mediate viral entry. (semanticscholar.org)
  • Identification and characterization of the viral interaction determinant of the subgroup A avian leukosis virus receptor. (semanticscholar.org)
  • The cloned virus was then serially passed three times in the presence of subneutralizing levels of this antiserum, and the resultant viral isolates were more resistant to antiserum neutralization in vitro than was the parent cloned virus. (uga.edu)
  • Two of the chicks that were not viremic at hatch developed viremia at one week of age and had viral tissue distribution suggesting oral exposure to the virus from their hatchmate. (uga.edu)
  • Histopathology, immunohistochemistry or fluorescent antibody tests to detect viral antigen in the tumors are needed to differentiate between Marek's disease virus (MDV), reticuloendotheliosis virus (REV) and avian leucosis virus. (hendrix-genetics.com)
  • As the capsid protein, P27 is the group-specific antigen of ALV and has many viral antigen sites, which enable the easy detection of the virus itself, and based on which ELISA or lateral flow immunoassay were further developed for laboratory testing purpose. (antibodymall.com)
  • The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus. (nih.gov)
  • The cellular receptor for subgroup A avian leukosis and sarcoma virus (ALSV-A) is Tva, which contains a motif related to repeats in the low density lipoprotein receptor (LDLR) ligand binding repeat (LBr) and which is necessary for viral entry. (nih.gov)
  • The host cell then treats the viral DNA as part of its own genome , transcribing and translating the viral genes along with the cell's own genes, producing the proteins required to assemble new copies of the virus. (wikipedia.org)
  • Osteopetrotic bone is also characterized by the accumulation of unintegrated viral DNA, suggesting an atypical life cycle of the virus in the infected osteoblasts. (umassmed.edu)
  • We now report a significant improvement made to this viral targeting method by using a related bridge protein, designated TVB-EGF, comprised of the extracellular domain of the TVB receptor for subgroup B avian leukosis virus fused to epidermal growth factor (EGF). (pnas.org)
  • The frequency of occurrence of 15B-E viruses was affected by the level of expression of V-15B and the presence of endogenous viral alleles which constitutively express subgroup E envelope antigens. (fhcrc.org)
  • Since the level of expression of V-15B and the presence of endogenous viral alleles which constitutively express subgroup E envelope antigens affected the frequency of occurrence of 15B-E viruses, we further suggest that 15B-ILV and RNAs which contain information for subgroup E envelope antigens are the parents of 158E viruses. (fhcrc.org)
  • These results suggest that CRISPR/Cas9-mediated genome editing can be used to efficiently modify avian cells and establish novel chicken cell lines with resistance to viral infection. (biomedcentral.com)
  • Susceptibility and resistance to the virus depend largely on specific host receptors that interact with viral envelope proteins. (biomedcentral.com)
  • Avian leukosis virus (ALV) has been used as a model system to understand the mechanism of pH-independent viral entry involving receptor-induced conformational changes in the viral envelope (Env) glycoprotein that lead to membrane fusion. (nih.gov)
  • The virus encodes a 135 kDa fusion protein which contains amino acid sequences derived from the viral Gag protein and the two cellular transcription factors c-Myb and c-Ets-1p68. (nih.gov)
  • Bovine viral diarrhea virus contamination of nutrient serum, cell cultures and viral vaccines. (greenmedinfo.com)
  • Any disruption of virus cell surfing significantly reduces viral infection. (rupress.org)
  • Enveloped virus entry is initiated by binding to surface receptors/coreceptors followed by trafficking to specific entry sites where viruses encounter a milieu that provides for activation of their fusion machine, the viral envelope glycoprotein (Env). (rupress.org)
  • Burmester BR, Fontes AK, Walter WG (1960) Pathogenicity of a viral strain (RPL 12) causing avian visceral lymphomatosis and related neoplasms. (springer.com)
  • Neiman P, Payne LN, Weiss RA (1980b) Viral DNA in bursal lymphomas induced by avian leukosis viruses. (springer.com)
  • Although the mechanism of virus-cell separation is unknown, it is well established that the Gag protein is the only viral product required for budding ( 27 ). (asm.org)
  • A sixth subgroup (E) designates nononcogenic endogenous viruses produced by viral genes integrated into the host cell DNA. (merckvetmanual.com)
  • We use a combination of molecular, cell biological, and genetic tools to understand how viruses invade host cells and evade host defenses with recent emphasis on emerging viral pathogens. (upenn.edu)
  • Although we work with a number of different viral systems, current projects concentrate on several pathogenic viruses including filoviruses (ebolavirus and Marburgvirus) and bunyaviruses (Hantaan, Andes, Sin Nombre, La Crosse). (upenn.edu)
  • Integration of viral DNA into host DNA was first discerned for the prophage of the temperate bacteriophage lambda by Andre Lwoff in 1950 and for the simian DNA virus SV40 in cultured mammalian cells in 1968 [ 8 ]. (royalsocietypublishing.org)
  • For small DNA tumour viruses, the full replication cycle occurs via non-integrated circular viral genomes, whereas viral integration into host DNA usually leads to abortive infection and sometimes to cell transformation. (royalsocietypublishing.org)
  • The AKR murine leukemia viruses do not contain acute transforming oncogenes ( 4 ) and are thought to transform cells as a result of activating cellular proto-oncogenes in the vicinity of viral integration into chromosomal DNA ( 5 ). (jimmunol.org)
  • Low freqeuncy production of recombinant subgroup E avian leukosis viruses by uninfected V-15B chicken cells. (fhcrc.org)
  • COMMA-1D cells were engineered to express the avian leukosis subtype A receptor, tv-a, to permit infection by recombinant avian leukosis virus produced by the replication-competent avian splice vector, RCAS. (aacrjournals.org)
  • We have developed a gene-trap lentiviral vector that act as an insertional mutagen and produced a library of >200 million haploid human cells bearing insertions and are interrogating this library by employing novel replication-competent, recombinant viruses. (upenn.edu)
  • Cells resistant to infection by these recombinant viruses contain inactivating mutations in host factors needed for infection that can be readily identified using massively parallel deep sequencing technology. (upenn.edu)
  • A highly specific ELISA for detection of Avian Leukosis Virus antigen, used in eradication programs. (biochek.com)
  • Western blot antibody reactivity of chicken sera to endogenous avian leukosis virus (ALV) (Rous-associated virus 0) antigen. (cdc.gov)
  • The gag (group antigen) gene encodes proteins that make up the nucleocapsid of the virus as well as a matrix layer, the two of which surround the RNA. (encyclopedia.com)
  • The specific detection of foot and mouth disease virus whole particle antigen (140 S) by enzyme labelled immunosorbent assay. (springer.com)
  • Members of this RNA group of viruses have similar physical and molecular characteristics and share a common group-specific antigen. (merckvetmanual.com)
  • Detection of the major antigen (p27) present in the core of leukosis/sarcoma viruses forms the basis of several diagnostic tests. (merckvetmanual.com)
  • Abstract To determine whether geese are infection of avian leukosis virus (ALV), 702 serum samples from domestic and foreign goose breeds were screened for p27 antigen as well as being inoculated into DF-1 cell cultures to isolate ALV. (medworm.com)
  • Recombination between two different subgroups of avian leukosis virus can occur in field conditions and cause economic losses. (merckvetmanual.com)
  • Exogenous leukosis viruses are transmitted as infectious virus particles. (hendrix-genetics.com)
  • By inoculation of blood samples in DF-1 (C/E) cell culture, an exogenous avian leukosis virus (ALV) strain SDAU09C2 was isolated from a breeder farm of Chinese native breed 'Luhua' in Shandong province. (bvsalud.org)
  • Avian leukosis virus (ALV) subgroup J is thought to have emerged through a recombination event between an unknown exogenous ALV and the endogenous retrovirus elements designated EAV-HP. (omicsdi.org)
  • Endogenous viruses integrate into host genomes and can recombine with exogenous avian leukosis virus (ALV). (frontiersin.org)
  • In 1961, Rous sarcoma virus (RSV), which is closely related to ASLV, was shown to contain RNA, and oncogenic viruses, such as RSV and ASLV, were termed RNA tumor viruses. (wikipedia.org)
  • The mechanism of interference between an avian leukosis virus and Rous sarcoma virus. (nih.gov)
  • The discoveries of Rous sarcoma virus, reverse transcriptase, and the Src oncogene were awarded Nobel Prizes in medicine and physiology in 1966, 1975, and 1989, respectively (Weiss and Vogt, 2011). (deepdyve.com)
  • Kinetic analysis of binding interaction between the subgroup A Rous sarcoma virus glycoprotein SU and its cognate receptor Tva: calcium is not required for ligand binding. (semanticscholar.org)
  • A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor. (semanticscholar.org)
  • PC, positive control, culture supernatant from Rous-associated virus 0 (RAV-0) infected 15B 1 chick embryo fibroblasts. (cdc.gov)
  • From 1959 to 1962 he was Damon Runyon Cancer Research Fellow in the laboratory of Harry Rubin at the University of California in Berkeley and started to work on Rous sarcoma virus. (wikipedia.org)
  • His work on mutants of the Rous sarcoma virus enabled Michael Bishop and Harold Varmus to isolate DNA sequences that represent the src oncogene and to demonstrate the cellular origin of oncogenes. (wikipedia.org)
  • however, recent studies of Rous sarcoma virus (RSV) and human immunodeficiency virus have suggested that modification of Gag with ubiquitin (Ub) is also required. (asm.org)
  • I first came across an endogenous factor which functionally complemented env -defective Rous sarcoma virus (RSV) during my doctoral studies in 1966. (royalsocietypublishing.org)
  • That was the year that Peyton Rous was awarded the Nobel Prize for Medicine or Physiology for the isolation of his eponymous virus published in 1911, representing a record 55 year incubation period between reporting a discovery and the award [ 6 ]. (royalsocietypublishing.org)
  • Maas HJL, Debber GF, Groenend JE (1982) Age-related resistance to avian-leukosis virus. (springer.com)
  • Avian sarcoma leukosis virus is characterized by a wide range of tumors, the most common of which are lymphomas. (wikipedia.org)
  • Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events. (asm.org)
  • There is a high prevalance rate for simian virus 40 in diffuse large B-cell lymphomas in Tunisia. (greenmedinfo.com)
  • 5 , 7 miR155 is derived from an exon of the B-cell integration cluster ( BIC ) gene, which was identified as a common integration site of avian leucosis virus in chicken B-cell lymphomas. (bloodjournal.org)
  • among our strains, five mutations were identical to those in the viruses causing hemangioma. (deepdyve.com)
  • All field strains of avian leukosis virus are oncogenic, although some differences in oncogenicity and replicative ability have been recognized. (merckvetmanual.com)
  • Historically, close contact of fowl with humans has been shown epidemiologically to foster cross-species jump (avian to human) of new influenza strains (e.g. (thefreedictionary.com)
  • A disease of birds due to strains of influenza A virus. (thefreedictionary.com)
  • Avian Influenza is caused by an Influenza virus of which there are several strains. (poultrykeeper.com)
  • Avian leukosis virus (ALV) is an oncogenic virus, an infectious disease causing tumors in poultry. (hendrix-genetics.com)
  • BackgroundAvian leukosis virus ALV is a major infectious disease that impacts the poultry industry worldwide. (duhnnae.com)
  • Rapid detection of antibodies of infectious bovine rhinotracheitis (IBR) virus by micro-enzyme linked immunosorbent assay (Micro-ELISA). (springer.com)
  • Selection of reference genes for gene expression analysis by real-time qPCR in avian cells infected with infectious bronchitis virus. (semanticscholar.org)
  • Here we show that the budding of equine infectious anemia virus (EIAV) from infected equine cells is largely unaffected by these drugs, although use of one inhibitor (MG-132) resulted in a dramatic block to proteolytic processing of Gag. (asm.org)
  • To further explore the requirements of Ub in retrovirus budding, we decided to test the sensitivity of equine infectious anemia virus (EIAV) to proteasome inhibitors. (asm.org)
  • Infectious bronchitis virus (IBV) is often detected together with H9N2, suggesting disease exacerbation in cases of co-infections. (medworm.com)
  • When we think of respiratory disease in poultry we often think of infectious bronchitis virus or Mycoplasma, however there is another rather harmful virus that belongs to the herpes virus family that causes ILT. (poultrykeeper.com)
  • However, T cells do not support lytic replication, while B cells spontaneously produce substantial amounts of infectious virus. (jci.org)
  • abstract = "The formation of the mature carboxyl terminus of CA in avian sarcoma/leukemia virus is the result of a sequence of cleavage events at three PR sites that lie between CA and NC in the Gag polyprotein. (uthscsa.edu)
  • abstract = "Three new erbB transducing viruses generated during avian leukosis virus-induced erythroblastosis have been cloned and sequenced, and their transforming abilities have been analyzed. (elsevier.com)
  • ez MF Abstract Since the emergence of low pathogenic avian influenza (LPAI) H9N2 viruses in Morocco in 2016, severe respiratory problems have been encountered in the field. (medworm.com)
  • Abstract Newcastle disease (ND), caused by virulent Avian avulavirus 1 (AAvV 1), affects a wide range of avian species worldwide. (medworm.com)
  • This virus efficiently induces erythroblastosis, but does not transform fibroblasts in vitro or induce sarcomas in vivo. (elsevier.com)
  • Here we show that virus binding to filopodia induces a rapid and highly ordered lateral movement, "surfing" toward the cell body before cell entry. (rupress.org)
  • Reply to commentary by D. Elleder and J. Hejnar on the article "Avian sarcoma and leukosis virus gag gene in the Anser anser domesticus genome" published in Genetics and Molecular Research 14 (4): 14379-14386 to the letter published in Genet. (geneticsmr.com)
  • Endogenous leukosis viruses are part of the chicken genome and are transmitted genetically. (hendrix-genetics.com)
  • A retrovirus is a type of RNA virus that inserts a copy of its genome into the DNA of a host cell that it invades, thus changing the genome of that cell. (wikipedia.org)
  • Once inside the host cell's cytoplasm , the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backwards). (wikipedia.org)
  • ResultsIn this study, the avian leukosis virus subgroup J ALV-J proviral genome, including the gag genes, were treated as targets for RNAi. (duhnnae.com)
  • Despite the discovery of specific host receptors that are critical for ALV entry, there has been only one report on the acquisition of resistance to ALV subgroup C in avian species via genome editing of host receptor genes. (biomedcentral.com)
  • This is a list of representative viruses (grouped by genome structure) compiled from: 'Virus Taxonomy', the Sixth Report of the International Committee on Taxonomy of Viruses (ICTV) 1995. (virology.net)
  • Virions (virus particles) contain two 5 ′ ("five prime"), end-linked, identical copies of the genome RNA, and are therefore said to be diploid. (encyclopedia.com)
  • In addition to piRNAs that protect the germ-line genome from transposon activation, mammals and avian produce a distinct and abundant set of non-repetitive piRNA sequences whose function is unknown. (rochester.edu)
  • Lymphoid leukosis is the most common form of this disease and with typical presentation of gradual onset, persistent low mortality, and neoplasia of the bursa. (wikipedia.org)
  • Lymphoid leukosis has a worldwide distribution, and is most commonly found in birds 16 weeks or older. (wikipedia.org)
  • Lymphoid leukosis was eradicated in primary breeders in the 1980s and 1990s which dramatically reduced the incidence of the disease in commercial laying hens. (wikipedia.org)
  • Hayward WS, Neel B, Astrin SM (1981) Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. (springer.com)
  • Lymphoid leukosis is a neoplastic disease of poultry caused by avian leukosis virus. (merckvetmanual.com)
  • A set of four specific primers was designed to target the sequences of the pol gene of ALV, and the loop-mediated isothermal amplification (LAMP) assay were developed and compared with PCR and virus isolation methods. (biomedcentral.com)
  • Antigenic variants of J subgroup avian leukosis virus: sequence analysis reveals multiple changes in the env gene. (microbiologyresearch.org)
  • The nucleotide sequence of the env gene of the variant viruses showed several substitutions resulting in amino acid changes especially clustered in the variable regions hr1, hr2 and vr3. (microbiologyresearch.org)
  • No nucleotide differences were detected between the env gene of the parent cloned virus and that of the neutralization-resistant mutants. (uga.edu)
  • Some of them contained antigens of avian leukosis virus (ALV) by immunohistochemistry,and the env gene of ALV subgroup J was detected from the spleens by polymerase chain reaction (PCR). (omicsdi.org)
  • Using this method, we efficiently modified the tumor virus locus B ( tvb ) gene, encoding the TVB receptor, which is essential for ALV subgroup B entry into host cells. (biomedcentral.com)
  • Retro-viruses are also valuable research tools in molecular biology and gene therapy. (encyclopedia.com)
  • The cTVA transgene contains the human ubiquitin C ( UBC ) promoter driving expression of a loxP -flanked destabilized green fluorescent protein (GFP) and polyadenylation sequence, followed by an avian specific retroviral receptor (TVA) gene derived from quail. (jax.org)
  • The cTVA transgene in this strain carries the human ubiquitin C ( UBC ) promoter/enhancer elements driving expression of a loxP -flanked destabilized green fluorescent protein (GFP) and polyadenylation sequence, followed by an avian specific retroviral receptor (TVA) gene derived from quail. (jax.org)
  • Differential host gene expression in cells infected with highly pathogenic H5N1 avian influenza viruses. (semanticscholar.org)
  • Avian leukosis virus (ALV) is one of the main causes of tumour development within the poultry industry in China. (beds.ac.uk)
  • Avian leukosis virus (ALV) is one of the major causes of disease in poultry, and commonly produces tumours in those infected. (beds.ac.uk)
  • ALV-infected poultry display several symptoms, including lymphoblastic, erythroblastic and osteopetrotic tumors, and the virus can be transmitted both vertically and horizontally. (biomedcentral.com)
  • The Avian Health Program offers diagnostic testing, consultation and extension services for commercial and backyard poultry producers. (cornell.edu)
  • Dr. Jarra Jagne , head of the Avian Health program and veterinarian specializing in poultry, a diplomate of the American College of Poultry Veterinarians, is available for disease, nutrition, health, and management consultation. (cornell.edu)
  • The Avian Health Program also provides support for meeting the requirements of the National Poultry Improvement Program (NPIP) and for exports. (cornell.edu)
  • Although wild birds, the natural hosts, seldom become sick when infected, avian influenza viruses can cause disease in domestic poultry and, rarely, in human beings. (thefreedictionary.com)
  • bird 'flu' caused by the H5N1 virus that caused epidemics in poultry in Japan, Korea, Thailand, China and Vietnam early in 2004. (thefreedictionary.com)
  • The very mention of the words Avian Influenza (AI) or Bird Flu strikes fear into the hearts of poultry keepers and the general public alike. (poultrykeeper.com)
  • Chicken endogenous viruses, ALVE (Avian Leukosis Virus subgroup E), are inherited as LTR (long terminal repeat) retrotransposons, which are negatively correlated with disease resistance, and any changes in DNA methylation may contribute to the susceptibility to neoplastic disease. (nih.gov)
  • Diagnosis of bovine leukosis: ELISA, a new technique. (springer.com)
  • Evaluation of the human host range of bovine and porcine viruses that may contaminate bovine serum and porcine trypsin used in the manufacture of biological products. (greenmedinfo.com)
  • Fetal bovine serum (FBS) was found to be contaminated with adventitious viruses. (greenmedinfo.com)
  • The use of the direct immunoperoxidase test to detect the multiplication of rinderpest virus in bovine kidney cell culture. (springer.com)
  • All virus isolation was performed in DF-1 cells. (cdc.gov)
  • Six isolates of ALV-J, named SDAU1701-SDAU1706, were characterized by virus isolation and sequence analysis of the complete proviral genomes. (deepdyve.com)
  • The results verify that the LAMP method was more sensitive than the conventional PCR and virus isolation method. (biomedcentral.com)
  • Virus isolation is generally the ideal detection method (so-called gold standard). (poultrydvm.com)
  • Moreover, no viremia was detected at 6 weeks after insemination even when virus isolation had been conducted six times at weekly intervals for each of the 12 females. (beds.ac.uk)
  • It would, therefore, seem appropriate to assign the first ""isolation"" of the virus to its continuous passage in monkeys by Stokes, et al. (cdc.gov)
  • The sensitivity and specificity of this new diagnostic method was compared to that of conventional diagnostic methods, namely virus isolation, immunofluorescence and histopathology. (springer.com)
  • That finding suggested that mutation of isolates in pheasants and quails was induced by selective pressure from the resistant host, and that the hr2 region is a critical domain in cross-species transmission of ALV-J. Sequencing showed that ALV-J isolates from turkeys, pheasants and quails had moved away from the original virus, and were closer to the ALV-J prototype strain HPRS-103. (bvsalud.org)
  • Cleavage of either 9 or 12 amino acids from the carboxyl terminus creates two mature CA species, named CA2 and CA3, that can be detected in avian sarcoma/leukemia virus (R. B. Pepinsky, I. A. Papayannopoulos, E. P. Chow, N. K. Krishna, R. C. Craven, and V. M. Vogt, J. Virol. (uthscsa.edu)
  • Yellow fever virus is the type species of the Group B arboviruses, or flavi- viruses. (cdc.gov)
  • The International Committee on Taxonomy of Viruses has designated avian leukosis virus as the type species within the Alpharetrovirus genus of the family Retroviridae . (merckvetmanual.com)
  • these viruses have not been isolated from other avian species except pheasants, partridges, and quail. (merckvetmanual.com)
  • Recently, several AAvVs of diverse genotypes have emerged with varying genomic and residue substitutions, and subsequent clinical impact on susceptible avian species. (medworm.com)
  • Wang, Xiaomei 2016-07-20 00:00:00 Avian leukosis virus (ALV) is an avian oncogenic retrovirus that can induce various clinical tumors. (deepdyve.com)
  • Avian leukosis virus subgroup J (ALV-J) is an avian retrovirus that can induce myelocytomas. (bvsalud.org)
  • Characterization of endogenous avian leukosis viruses in chicken embryonic fibroblast substrates used in production of measles and mumps vaccines. (greenmedinfo.com)
  • Murine leukemia virus (MLV), in contrast, showed an integration bias in favor of CpG islands and transcription start sites ( 31 ) and a weaker preference for transcription units. (asm.org)
  • This product is a murine monoclonal antibody against avian leukosis virus. (antibodymall.com)
  • Distribution of xenotropic murine leukemia virus-related virus (XMRV) infection in chronic fatigue syndrome and prostate cancer. (greenmedinfo.com)
  • Avian leukosis virus subgroup J was identified by an immunofluorescence assay with monoclonal antibody JE9, whereas Marek's disease virus or reticuloendotheliosis virus was not detected. (deepdyve.com)
  • Unlike Marek's disease , vertical transmission is the biggest player in moving this virus into the population at large. (everything2.com)
  • Analysis of the expression profiles of Marek's disease virus-encoded microRNAs by real-time quantitative PCR. (semanticscholar.org)
  • ERVs are found at many loci in host DNA and also in the genomes of large DNA viruses, such as herpesviruses and poxviruses. (royalsocietypublishing.org)
  • 2016). Subgroup J avian leukosis virus (ALV-J) was first isolated and identified in 1988 in the United Kingdom (Payne et al. (deepdyve.com)
  • 2016. "The European Classical Swine Fever Virus Database: Blueprint for a Pathogen-Specific Sequence Database with Integrated Sequence Analysis Tools. (mdpi.com)
  • A detailed understanding of retroviral cell entry may lead to the discovery of ways in which to block the viruses from entering cells. (wikipedia.org)
  • However, cells preinfected with ALV-E are resistant only to superinfection by subgroup E viruses. (pnas.org)
  • Studies of several thousand sites of human immunodeficiency virus (HIV) integration in human cells indicated that transcription units (TUs) are favored for integration, and comparison to transcriptional profiles from target cells indicates that active TUs are particularly favored ( 19 , 26 , 31 ). (asm.org)
  • How did a porcine virus contaminate Rotarix, which is produced in Vero cells? (clinicalnews.org)
  • Furthermore, virions preloaded with TVB-EGF were thermostable and could be produced directly from virus- packaging cells. (pnas.org)
  • In this paper we present evidence that uninfected 15B cells also produce subgroup E viruses, designated 15B-E viruses. (fhcrc.org)
  • Since 15B-E isolates occurred in uninfected cells and contained proteins which are characteristic of RAV-0 and recombinants of RAV-0, we suggest that 15B-E viruses are recombinants of endogenous virus information. (fhcrc.org)
  • This indicates that the virus cannot proliferate in the germ cells. (beds.ac.uk)
  • Naturally occurring genetic mutations in the host receptors, or artificial expression of mutant receptors in host cells, can affect susceptibility to the virus. (biomedcentral.com)
  • Experiences of virus, retrovirus and retrovirus-like particles in Chinese hamster ovary (CHO) and hybridoma cells used for production of protein therapeutics. (greenmedinfo.com)
  • Viruses have often been observed in association with the dense microvilli of polarized epithelia as well as the filopodia of nonpolarized cells, yet whether interactions with these structures contribute to infection has remained unknown. (rupress.org)
  • Chicken embryo fibroblasts (CEFs) are among the most commonly used cells for the study of interactions between chicken hosts and H5N1 avian influenza virus (AIV). (semanticscholar.org)
  • This lack of sensitivity was also observed in transiently transfected avian cells under conditions that greatly reduce RSV budding. (asm.org)
  • Proteasome inhibitors, which deplete the intracellular levels of free Ub, dramatically reduce budding, resulting in the accumulation of virus particles on the surfaces of infected cells ( 19 , 24 ). (asm.org)
  • The Bates lab is interested in the interactions between viruses and their host cells. (upenn.edu)
  • The recent availability of haploid mammalian cells makes possible the use of this technology to identify host factors that interact with viruses and promote infection. (upenn.edu)
  • When mixed cultures of B cells and activated T cells were exposed to KSHV, little spontaneous virus production was observed. (jci.org)
  • Removing T cells from the mix or treating the mixed culture with immune suppressants enhanced virus production. (jci.org)
  • Identifying these cells would provide direct insight into KSHV transmission and virus-induced transformation. (jci.org)
  • For pH-independent viruses, a critical concentration of receptors/coreceptors may suffice to induce fusion at the plasma membrane, while pH-dependent viruses must reach an endosomal environment for fusion to be triggered by low pH. (rupress.org)
  • A soluble form of a receptor for subgroup A avian leukosis and sarcoma viruses (ALSV-A) blocks infection and binds directly to ALSV-A. (semanticscholar.org)
  • The bridge protein tested was comprised of the low density lipoprotein receptor-related extracellular domain of the TVA receptor for subgroup A avian leukosis virus (ALV-A) fused to human epidermal growth factor (EGF). (pnas.org)
  • I haven't read anything stating that any of these diseases are zoonotic , but you never want to pop a new RNA virus into anyone, just in case. (everything2.com)
  • Avian Diseases 63-3 Table of Contents. (medworm.com)
  • The receptor for the subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not to subgroup C envelope glycoprotein. (semanticscholar.org)
  • ASLV is a Group VI virus of the family Retroviridae. (wikipedia.org)
  • Receptor specificity in avian sarcoma and leukosis viruses (ASLV) maps to the central region of the envelope surface protein, SU. (semanticscholar.org)
  • The ASLV TM glycoprotein has been proposed to adopt a structure similar to that of the Ebola virus GP2 protein: each contains an internal fusion peptide flanked by cysteine residues predicted to be in a disulfide bond. (mendeley.com)
  • 2011). From 2007 to 2010, hemangioma was the most hazardous neoplastic disease associated with ALV-J, which caused a massive pandemic and became a major avian health concern. (deepdyve.com)
  • However, the strain of yellow fever virus that was passed by Reed, et al. (cdc.gov)
  • Experimental infection of North American birds with the New York 1999 strain of West Nile virus. (ajtmh.org)
  • Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex. (semanticscholar.org)
  • These results suggest that MAB may influence the development of viremia, antibody, and shedding of ALV following massive exposure to virus at hatching. (docphin.com)
  • This Anti avian leukosis virus P27 protein monoclonal antibody is used in immunoassays to detect ALV specificly. (antibodymall.com)
  • The avian antibody response. (ajtmh.org)
  • Passive West Nile virus antibody transfer from maternal Eastern screech-owls ( Megascops asio ) to progeny. (ajtmh.org)
  • This method utilizes either a biotinylated monoclonal antibody to Bluetongue virus and streptavadin-enzyme in conjunction with synthetic substrate, or an enzyme-conjugated monoclonal to detect antibodies specific for Bluetongue virus. (google.com)
  • Structural dynamics and local changes in the dimerization site of avian retroviral RNA were studied. (jbsdonline.com)
  • The steps that differ from other viruses involve the retroviral reverse transcriptase, an enzyme discovered simultaneously by Howard Temin and David Baltimore in 1970. (encyclopedia.com)
  • The reason for the nonreciprocal receptor interference pattern exhibited by these viruses remains to be determined. (pnas.org)
  • Inhibition of avian leukosis virus replication by vector-based RNA interference. (harvard.edu)
  • Hence, it is an enveloped virus with a condensed, central core, and has barely visible envelope spikes, or proteins. (wikipedia.org)
  • To study the importance of each of the three CA proteins, we introduced amino acid substitutions into each CA cleavage junction and studied their effects on CA processing as well as virus assembly and infectivity. (uthscsa.edu)
  • These results support the idea that infectivity of the virus is closely linked to proper processing of the carboxyl terminus to form two mature CA proteins. (uthscsa.edu)
  • The proteins of nine independent isolates of 15B-E viruses were analyzed by SDS-polyacrylamide gel electrophoresis. (fhcrc.org)
  • All isolates had p27 proteins with the distinctive electrophoretic mobility of the p27 of RAV-0, an endogenous virus. (fhcrc.org)
  • Roughly 1,500 Gag molecules come together to make a virus particle ( 29 ), and the primary interactions among these proteins are provided by the I domain. (asm.org)
  • Avian Leukosis is a neoplastic disease caused by the (aptly named) Avian Leukosis virus (ALV). (everything2.com)
  • To avoid the generation of escape variants during virus infection, expression vectors of multi-target miRNAs were constructed using the multi-target serial strategy against different regions of the gag, pol, and env genes. (duhnnae.com)
  • 2000. Cospeciation and horizontal transmission of avian sarcoma and leukosis virus gag genes in galliform birds. (tolweb.org)
  • Thus, the avian nephroblastoma is a valid source of cancer-associated genes. (aacrjournals.org)
  • Here, we report the unexpected finding that ALV entry depends on a critical low pH step that was overlooked when this virus was directly compared to the classical pH-dependent influenza A virus. (nih.gov)
  • In contrast to influenza A virus, receptor interaction plays an essential role in priming ALV Env for subsequent low pH triggering. (nih.gov)