Genomic analysis of closely related astroviruses. (1/10)

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Detection of Turkey astrovirus in young poults affected with poult enteritis complex in Brazil. (2/10)

Reverse transcription polymerase chain reaction (RT-PCR) of turkey astrovirus (TAstV) capsid and polymerase genes was applied to the bursa of Fabricius (BF), thymus (TH), spleen (SP) and cloacal swabs (CS) of young poults with "Poult enteritis complex" (PEC). The histological lesions included atrophy, lymphoid depletion, cellular infiltration and necrosis of the BF, TH and SP, respectively. The RT-PCR reactions were positive for the polymerase gene of TAstV-2 in all 100 CSs, 7 out of 10 of BFs and 10 out of 20 THs and SPs, respectively. Five out of 10 THs and SPs samples, considered to be negative by RT-PCR, were positive when specific primers designed for the TAstV-2 capsid gene were applied. This is the first description of turkey astrovirus infection presenting PEC in Latin America.  (+info)

Complete sequence of a duck astrovirus associated with fatal hepatitis in ducklings. (3/10)

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Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expression. (4/10)

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One-year molecular survey of astrovirus infection in turkeys in Poland. (5/10)

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Crystal structure of the human astrovirus capsid spike. (6/10)

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Screening of feral and wood pigeons for viruses harbouring a conserved mobile viral element: characterization of novel Astroviruses and Picornaviruses. (7/10)

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Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection. (8/10)

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There have been some evidence that there are distinct subtypes of turkey astrovirus. Strain et.al., performed experiment in differentiating the types of turkey astrovirus. Predicted capsid amino acid sequences were first used to assessed the relationship of the novel clinical TAstV isolates within the Astroviridae 6. The TAstV-1 capsid sequence was found in a clade containing avian nephritis virus, with distance between it and the TAstV-1. Sequence analysis of TastV-1 and TastV-2 diagnostic amplicons was used to demonstrate that the levels of variation among TastV-1 and TastV-2 are very diverse. The phylogenetic analysis of the full-length capsid genes of both types of Tast-V shows that both may have originated from separate introductions into the turkey species and that there are at least two lineages which are distinct subtypes instead of serotypes. There are potential serotypes to appear within each subtypes. A computer analysis was done by Jonassesen et.al. that focused on the ORF1a gene ...
There have been some evidence that there are distinct subtypes of turkey astrovirus. Strain et.al., performed experiment in differentiating the types of turkey astrovirus. Predicted capsid amino acid sequences were first used to assessed the relationship of the novel clinical TAstV isolates within the Astroviridae 6. The TAstV-1 capsid sequence was found in a clade containing avian nephritis virus, with distance between it and the TAstV-1. Sequence analysis of TastV-1 and TastV-2 diagnostic amplicons was used to demonstrate that the levels of variation among TastV-1 and TastV-2 are very diverse. The phylogenetic analysis of the full-length capsid genes of both types of Tast-V shows that both may have originated from separate introductions into the turkey species and that there are at least two lineages which are distinct subtypes instead of serotypes. There are potential serotypes to appear within each subtypes. A computer analysis was done by Jonassesen et.al. that focused on the ORF1a gene ...
Not very far, Munnar compliments the Thattekkad Sanctuary well due to its altitude. It is a hill station 125 kms from Kochi to the West. The altitude above 1600 m above MSL means an agreeable climate throughout the year, though in December-January the temperatures can fall to the single digits. The rain fall of over 300 cm is recorded mainly during June to September. The shola-grassland eco- system so typical of Munnar is home to large numbers of birds, many of them endemic. Sightings of endemics like the Nilgiri Wood Pigeon, Nilgiri Pipit, Greyheaded Bulbul, Black & Orange Flycatcher, Broadtailed Grassbird, Crimsonbacked Sunbird, Greybreasted Laughing Thrush, Nilgiri Flycatcher, Indian Rufous Babbler, Whitebellied Blue Flycatcher, Whitebellied Shortwing, Whitebellied Treepie & the Wyanad Laughing Thrush can be the highlights of a birding trip to Munnar & surroundings ...
The reverse transcription polymerase chain reaction (RT-PCR) of turkey astrovirus(TAstV) capsid and polymerase gene was applied in the bursa of Fabricius (BF),thymus (TH), spleen (SP) and cloacal swabs (CS) from young poults with PEMS(Poult Enteritis Mortality Syndrome). The histological lesions were atrophy,lymphoid depletion, cellular infiltration and necrosis of BF, TH and SP,respectively. The RT-PCR reactions were positive in all of 100 CS, 7 out of 10 ofBF, 10 out of 20 TH and SP, respectively, for the polymerase gene of TAstV-2.Five out of 10 TH and SP samples, considered as negative by RT-PCR, werepositive when specific primers designed to the TAstV-2 capsid gene were applied.Finally, this is the first description of turkey astrovirus infection presenting PEMS inLatin America ...
The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016 ...
Aging-associated changes in the heart contribute to a wide variety of cardiovascular diseases. The aging atrium becomes increasingly more susceptible to development of atrial fibrillation, and even its pharmacological response to therapeutic drugs alters over time. Changes in structure, function, and pharmacology of the heart can potentially be tied to specific changes in gene expression with aging. Here, seeking molecular correlates of myocardial aging processes, we performed global whole transcript analysis of 25,388 genes using 572,667 probes to compare the left atrium (LA) transcriptomes of young adult (9 months old) versus elderly (10 years old) female Sinclair swine. The two genes exhibiting the largest increase in LA expression with aging were NHE2 (9.2-fold; n = 3-4; P = 0.00001) and KCNIP2 (3.8-fold; n = 3-4; P = 0.0002). Real-time qPCR recapitulated the NHE2 results and revealed strongest upregulation with aging in LA, and age-independent expression in the ventricles. NHE2 encodes ...
Goat polyclonal Sodium / Hydrogen Exchanger 1 antibody validated for WB and tested in Human. Immunogen corresponding to synthetic peptide
Rabbit polyclonal Sodium / Hydrogen Exchanger 1 antibody validated for WB, IHC, ICC/IF and tested in Human, Mouse and Rat. Referenced in 4 publications…
Protein names and data: SL9B2_HUMAN, Full=Mitochondrial sodium/hydrogen exchanger 9B2, Full=Mitochondrial Na(+)/H(+) exchanger NHA2;Full=Na(+)/H(+) exchanger-like domain-containing protein 2;Short=NHE domain-containing protein 2;Full=Sodium/hydrogen exchanger-like domain-containing protein 2;Full=Solute carrier family 9 subfamily B member 2; Length: 537 a.a., Mass: 57564 Da ...
MURF2 antibody (solute carrier family 9 (sodium/hydrogen exchanger), member 7) for IHC-Fr, WB. Anti-MURF2 pAb (GTX24387) is tested in Human, Zebrafish samples. 100% Ab-Assurance.
NHERF1 antibody [EBP-10] (solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1) for IHC-P, IP, WB. Anti-NHERF1 mAb (GTX29526) is tested in Human samples. 100% Ab-Assurance.
Severe and sometimes fatal hepatitis associated with isoniazid therapy has been reported and may occur or may develop even after many months of treatment. The risk of developing hepatitis is age related. Approximate case rates by age are: less than 1 per 1,000 for persons under 20 years of age, 3 per 1,000 for persons in the 20-34 year age group, 12 per 1,000 for persons in the 35-49 year age group, 23 per 1,000 for persons in the 50-64 year age group, and 8 per 1,000 for persons over 65 years of age. The risk of hepatitis is increased with daily consumption of alcohol. Precise data to provide a fatality rate for isoniazid-related hepatitis is not available; however, in a U.S. Public Health Service Surveillance Study of 13,838 persons taking isoniazid, there were 8 deaths among 174 cases of hepatitis.. Therefore, patients given isoniazid should be carefully monitored and interviewed at monthly intervals. For persons 35 and older, in addition to monthly symptom reviews, hepatic enzymes ...
Severe and sometimes fatal hepatitis associated with isoniazid therapy has been reported and may occur or may develop even after many months of treatment. The risk of developing hepatitis is age related. Approximate case rates by age are: less than 1 per 1,000 for persons under 20 years of age, 3 per 1,000 for persons in the 20 to 34 year age group, 12 per 1,000 for persons in the 35 to 49 year age group, 23 per 1,000 for persons in the 50 to 64 year age group, and 8 per 1,000 for persons over 65 years of age. The risk of hepatitis is increased with daily consumption of alcohol. Precise data to provide a fatality rate for isoniazid-related hepatitis is not available; however, in a U.S. Public Health Service Surveillance Study of 13,838 persons taking isoniazid, there were 8 deaths among 174 cases of hepatitis.. Therefore, patients given isoniazid should be carefully monitored and interviewed at monthly intervals. For persons 35 and older, in addition to monthly symptom reviews, hepatic enzymes ...
A Las Vegas clinic had been reusing syringes and vials of medication for nearly four years. The shoddy practices may have led to an outbreak of the potentially fatal hepatitis C virus and exposed patients to HIV.
The maggot will die, and the sick will recover.. One thing though that he apparently got wrong is that it is the adult beetle - having emerged from its pupa but still in the pupal chamber under the timber surface that knocks on the wood, and not the larvae!. ITS NOTHING TO DO WITH DYING OR EVEN WITH WILDLIFE AND BUILDINGS - or so it would seem but, during the Summer months, Wood Pigeons are often seen and heard with their coo-coo coo coo-coo (or my toes bleeding, Mary). As they are disturbed from roosting in tall hedges or woodland edges they make that typical pigeon flapping of their wings against leaves and small branches that is so easily identifiable from other bird species. In the old days, that Summer cooing always seemed to represent those hot afternoons in July when the family had brought out tea and cakes - usually scones, to refuel those of us moving bales of hay before coming back after milking time to pick them up and load them onto a trailer to take back to the farm for ...
The much maligned Wood Pigeons were all at it in the evening light yesterday...just after this the Male jumped onto her for a special moment..I was too slow to capture it though....the Male is on the left. Keith
MetabolismTransport and binding proteinsCations and iron carrying compoundssodium/hydrogen exchanger 3 (TIGR00840; HMM-score: 56.7) ...
Promyelocytic leukemia protein nuclear bodies (PML NBs) have been implicated in host immune system response to viral infection. in EBV contaminated alveolar epithelial cells and nasopharyngeal carcinoma cells. Treatment with low dosage arsenic trioxide disrupted PML NBs induced manifestation of EBV lytic protein and conferred ganciclovir susceptibility. This research introduces a highly effective modality to induce susceptibility to ganciclovir in epithelial cells with implications for the treating EBV connected pathologies. family. People of alpha (HERPES VIRUS 1 (HSV1)) beta (Human being Cytomegalovirus (CMV)) and gamma (EBV) subfamilies encoded IE protein (ICP0 IE1 Zta respectively) have already been shown to connect to and disperse PML NB by special systems (Adamson and Kenney 2001 Ahn et al. 1998 Adamson and Bowling 2006 Everett and Maul 1994 Kelly et al. 1995 Maul and Everett 1994 Furthermore at lytic initiation HSV1 CMV and EBV genomes localize to PML NB as sites for viral replication ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Background A T cell costimulatory molecule with dipeptidyl peptidase IV (DPPIV) activity in its extracellular area, Compact disc26 is a multifunctional molecule connected with various protein such as for example adenosine deaminase, caveolin-1, CXCR4, collagen, and fibronectin, while using a significant function in the regulation of inflammatory tumor and replies biology. molecule in the formalin-fixed paraffin-embedded tissue is critical. SOLUTIONS TO develop book anti-CD26 mAbs with the capacity of binding towards the denatured Compact disc26, we immunized mice with Compact disc26 proteins denatured in urea buffer. Following the fusion of myeloma and splenocytes cells, the mAbs had been screened for particular reactivity with individual Compact disc26 by stream cytometry, enzyme-linked immunosorbent assay, and immunohistochemistry. The binding competitiveness of novel anti-CD26 mAbs using the humanized anti-CD26 mAb YS110 was also analyzed. Results Weve been successful in developing book ...
The bovine rotavirus (BRV) WC3 serves as the background strain in the development of a multivalent reassortant vaccine against rotavirus gastroenteritis in infants. The genes encoding the outer capsid spike protein VP4, the inner capsid protein VP6, the outer capsid glycoprotein VP7, and the viral e …
Christianson syndrome is caused by mutations in the SLC9A6 gene, which provides instructions for making a protein called sodium/hydrogen exchanger 6 (Na+/H+ exchanger 6 or NHE6). The NHE6 protein is found in the membrane surrounding endosomes, which are compartments within cells that recycle proteins and other materials. The NHE6 protein acts as a channel to exchange positively charged atoms (ions) of sodium (Na+) with hydrogen ions (H+). By controlling the amount of hydrogen ions, the NHE6 protein helps regulate the relative acidity (pH) inside endosomes, which is important for the recycling function of these compartments. The NHE6 protein may have additional functions, such as helping to move proteins to the correct location in the cell (protein trafficking).. Mutations in the SLC9A6 gene typically lead to an abnormally short NHE6 protein that is nonfunctional or that is broken down quickly in cells, resulting in the absence of functional NHE6 channels. As a result, the pH in endosomes is not ...
Sodium hydrogen exchanger (SHE) inhibitor is one of the most important targets in treatment of myocardial ischemia. In the course of our research into new types of non-acylguanidine, SHE inhibitory activities of 5-tetrahydroquinolinylidine aminoguanidine derivatives were used to build pharmacophore and 3D-QSAR models. Genetic Algorithm Similarity Program (GASP) was used to derive a 3D pharmacophore model which was used in effective alignment of data set. Eight molecules were selected on the basis of structure diversity to build 10 different pharmacophore models. Model 1 was considered as the best model as it has highest fitness score compared to other nine models. The obtained model contained two acceptor sites, two donor atoms and one hydrophobic region. Pharmacophore modeling was followed by substructure searching and virtual screening. The best CoMFA model, representing steric and electrostatic fields, obtained for 30 training set molecules was statistically significant with cross-validated ...
Theres some interesting background on immunizations and human fetal tissue from the National Network for Immunization Information here which explains the vaccine/fetus link. Basically, some vaccines against viruses require human tissue to produce; a virus has to have a living host in which to grow, and using animal cells is not always practical or safe. While scientific advances have changed this in some cases - for example, the current Hepatitis B vaccine is made without human cells - currently approved vaccines for Hepatitis A, rubella, and rabies are derived from human tissue.. The Catholic Church has weighed in on this, saying that Catholics have a right to refuse these vaccines, but are not required to.. Most people dont get hepatitis vaccines of any variety, because theyre not at a high risk for the diseases; however, certain people should get vaccinated. Health care workers, who face a serious risk of exposure to debilitating and potentially fatal hepatitis B, are vaccinated against ...
Sodium hydrogen difluoride 1333-83-1 MSDS report, Sodium hydrogen difluoride MSDS safety technical specifications search, Sodium hydrogen difluoride safety information specifications ect.
Sodium hydrogen sulfate | NaHSO4 or HNaO4S | CID 516919 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Astrovirus infections cause gastroenteritis in mammals and have been identified as causative agents of diverse pathologies in birds such as hepatitis in ducks and poult enteritis mortality syndrome...
Find here sodium hydrogen phosphate manufacturers, sodium hydrogen phosphate suppliers, sodium hydrogen phosphate exporters, sodium hydrogen phosphate importers. Get contact address of sodium hydrogen phosphate manufacturing and supplying companies of India.
Hence these flowers are not native to our bird species & not evolved with them; so they may use them differently then evolution intended.. 2. David Wells to Amar-Singh and Rosli Omar. The very fact that this correspondence between dedicated observers is going on suggests to me one thing: that flower-petal eating by birds is out-of-the-ordinary/unusual behaviour - and that might this might narrow down the range of possible explanations. Might these involve secondary compounds with a flower protective function, bad tasting but also with some medicinal properties? Note that, in the UK, Wood Pigeons and Bullfinches are notorious strippers of cherry and plum etc. flower buds in late winter - but perhaps before such compounds have fully developed. All interesting speculation.. 3. Rosli Omar to Amar-Singh. What I dont understand is, why would plants provide flowers that are beneficial when eaten by animals? That would defeat the role played by the flowers ie., to attract animals to go for the nectar ...
Research Summary: The report presents detailed overview of the Sodium Hydrogen Carbonate market in the world and regions (CIS countries in particular) by contemplating and analyzing its various parameters. Firstly, brief introduction is provided. Thus, sodium hydrogen carbonate properties, application areas and manufacturing technologies are considered. Further goes the analysis of global sodium hydrogen carbonate market with […].... ...
China Sodium Hydrogen Sulfite Pressure Drying Machine, Find details about China Pressure Spray Dryer, Madecine Spray Dryer from Sodium Hydrogen Sulfite Pressure Drying Machine - Jiangsu Yutong Drying Engineering Co., Ltd.
Annexe Chem Pvt Ltd. started in 2008 as leading manufacturer,supplier,exporter of Di Sodium Hydrogen Phosphate Dodecahydrate Pure from Vadodara,Gujarat,India.The quality of the ingredients used and the final Di Sodium Hydrogen Phosphate Dodecahydrate Pure is thoroughly tested by our quality analysts.
Annexe Chem Pvt Ltd. started in 2008 as leading manufacturer,supplier,exporter of Di Sodium Hydrogen Phosphate Dehydrate USP from Vadodara,Gujarat,India.The quality of the ingredients used and the final Di Sodium Hydrogen Phosphate Dehydrate USP is thoroughly tested by our quality analysts.
Read independent reviews on di -Sodium hydrogen phosphate dodecahydrate BioChemica (A3906) from AppliChem GmbH on SelectScience
Sodium Hydrogen Periodate Na3H2IO6 bulk & research qty manufacturer. Properties, SDS, Applications, Price. Free samples program. Term contracts & credit cards/PayPal accepted.
Until today, classic human astroviruses have not been associated with central nervous system infections in immunocompetent patients. A 16-month-old Caucasian girl presented with repetitive generalized seizures with a 4-day history of watery diarrhea, which had already gradually improved. Initially, the prolonged seizures ceased after systemic midazolam treatment and were thought to be fever associated. However, her mental status remained altered, and after seizure recurrence, she was transferred to our pediatric intensive care unit. Seizure control was achieved by a combination of high-dose levetiracetam and phenobarbital, but she remained unconscious. An electroencephalogram at this time revealed generalized high voltage theta activity. All laboratory analyses, including extended blood and cerebrospinal fluid analyses, and a brain magnetic resonance imaging were normal. On day 4, the child gradually became conscious, but was very agitated and not able to walk. Since an electroencephalogram at this time
Rohloff, P., Miranda, K., Rodrigues, J.C.F., Fang, J., Plattner, H., Hentschel, J., Galizzi, M. and Moreno, S.N.J. (2011) Calcium uptake and proton transport by acidocalcisomes of Toxoplasma gondii. Plos One. 2011 6(4):e18390.. Moreno, S.N.J., Ayong L. and Pace, D.A. Calcium storage and function in apicomplexan parasites. (2011). Invited chapter. Essays in Biochem. 51:97-110.. Nair, S., Brooks, C.F., Goodman, C.D., Strurm, A., McFadden, G.I., Sundriyal, S., Anglin, J.L., Song,Y., Moreno, S.N.J. and Striepen B. (2011) Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance. J. Exp. Med. 208:1547-1559. Francia, M.E. Wicher, S., Pace, D.A., Moreno, S.N.J., Arrizabalaga, G. (2011) A Toxoplasma protein with homology to intracellular type Sodium Hydrogen Exchangers is required for osmotolerance and protein processing. Exp. Cell Res. 317:1382. Pace, D.A., Fang, J., Cintron, R., Docampo, M.D., Moreno, S.N.J. (2011) Overexpression of a cytosolic pyrophosphatase ...
Panaji: Twelve species of birds in Western Ghat`s region of Goa have been categorised as threatened by the International Union for Conservation of Nature (IUCN).. According to Parag Rangnekar, a senior member of Indian Bird Conservation Network (IBCN) Of these 12, two are critically endangered, six are vulnerable and four are nearly threatened.. Bird species including white-backed Vulture, long-billed Vulture, Malabar Pied Hornbill, Nilgiri Wood Pigeon and Great Pied Hornbill are among those who may be facing extinction from forests around Goa.. The reasons, he said, are diverse. In case of vultures it has been the veterinary drug, diclofenac, which has been responsible but the major cause in most cases is loss of habitat, he said.. Environmentalists say that protecting these bird species has become a priority since loss of their habitat is a major cause of this situation. Specifically for vultures, banning diclofenac completely is the need. Long-term approach is also of creating awareness ...
It was very cold in the morning and it even snowed until noon. In the afternoon it was very sunny and the snow melted. Today is one of the best days of ringing since we started since March 15. We also saw 3 black vultures soaring over our station. Sedat and Onder drove to Tuzluca for shopping and saw a dog carcass hit by a car on the way. They carried it on the other side of Aras river just opposite of our station to attract vultures. The carcass is visible from the station and even magpies started to come today. We also had a very new species of Aras station and ringed a wood pigeon.The other interesting bird of the day was a male sparrowhawk that we ringed. We ringed 30 birds out of 10 species ...
The prevalence of the recently identified astrovirus MLB1 in a cohort of children with diarrhea in St. Louis, Missouri, USA, was defined by reverse transcription-PCR. Of 254 stool specimens collected in 2008, 4 were positive for astrovirus MLB1. These results show that astrovirus MLB1 is circulating in North America.
KUNJAN SILICATE PVT. LTD. - Manufacturer, Distributor, Supplier, Trading Company of Sodium hydrogen sulphate based in Ahmedabad, India
I need to work out what an unkonwn solution is , with different tests one of them was with potassium manganate(vii) , it turned brown, so I thought it was an alkene but it also reacted with sodium hydrogen carbonate but I dont know if alkenes do or ...
Houston, D. K., Tooze, J. A., Neiberg, R. H., Hausman, D. B., Johnson, M. A., Cauley, J. A., Bauer, D. C., Cawthon, P. M., Shea, M. K., Schwartz, G. G., Williamson, J. D., Tylavsky, F. A., Visser, M., Simonsick, E. M., Harris, T. B., Kritchevsky, S. B. & Health ABC Study, 1 Dec 2012, In : American Journal of Epidemiology. 176, 11, p. 1025-1034 10 p.. Research output: Contribution to Journal › Article › Academic › peer-review ...
Mitochondrial Ca2+ is vital to mitochondrial function because it regulates the activities of Ca2+‐sensitive enzymes in the Krebs cycle.31 The regulation of mitochondrial Ca2+ homeostasis is complicated, including a pro‐uptake mitochondrial calcium uniporter, a prorelease sodium‐calcium exchanger, a sodium‐hydrogen exchanger, and a mitochondrial permeability transition pore.1, 32 In this study, we provide evidence to show that elevated mitochondrial TRPC3 expression is associated with enhanced mitochondrial Ca2+ uptake in hypertension and that telmisartan can decrease mitochondrial Ca2+ uptake by inhibiting TRPC3 in the vasculature from SHRs. Recently, Feng et al reported that ≈44% of total TRPC3 is localized to the inner membrane of mitochondria.14 We confirmed that mitochondrial TRPC3 expression was increased by 56% in the VSMCs from SHRs compared with WKY rats, whereas treatment with ATP enhanced the [Ca2+]mito in the permeabilized VSMCs from SHRs compared with WKY rats. Inhibition ...
Since they were identified in 1975, human astroviruses have been considered one of the most important agents of viral acute gastroenteritis in children. However, highly divergent astroviruses infecting humans have been recently discovered and associated with extra-intestinal infections. The report of cases of fatal meningitis and encephalitis, especially in immunocompromised individuals, has broadened their disease spectrum. Although zoonotic transmission among animal and human astroviruses has not been clearly recognized, the genetic similarity between some human and animal viruses makes it likely to occur. This review provides an update on the epidemiology of both classic and novel human astroviruses, and a comprehensive view on confirmed or potential association between astrovirus and human disease.
Infectious diarrhea leads to significant mortality in children, with 40 % of these deaths occurring in Africa. Classic human astroviruses are a well-established etiology of diarrhea. In recent years, seven novel astroviruses have been discovered (MLB1, MLB2, MLB3, VA1/HMO-C, VA2/HMO-B, VA3/HMO-A, VA4); however, there have been few studies on their prevalence or potential association with diarrhea. To investigate the prevalence and diversity of these classic and recently described astroviruses in a pediatric population, a case-control study was performed. Nine hundred and forty nine stools were previously collected from cases of moderate-to-severe diarrhea and matched controls of patients less than 5 years of age in Kenya and The Gambia. RT-PCR screening was performed using pan-astrovirus primers. Astroviruses were present in 9.9 % of all stool samples. MLB3 was the most common astrovirus with a prevalence of 2.6 %. Two subtypes of MLB3 were detected that varied based on location in Africa. In this case
Most astrovirus infections in humans are detected in the winter months (in temperate regions) and in the rainy season (in tropical climates). Incubation period: 3-4 days Associated diseases: gastroenteritis, celiac disease, intussusception (Fields 622). Symptoms: diarrhea in 72% - 100% in all cases, duration from 2-3 days Abdominal pain: 50% Vomiting: 20% - 70% Fever…
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7558-79-4 Sodium phosphate dibasic (sodium hydrogen phosphate) testing. Laboratory testing for CAS number 7558-79-4. . This chemical is white granular powder
Human astroviruses (HAstVs) are members of the Astroviridae family which are recognized as one of the most common cause of viral gastroenter...
Incidence and Prevalent Types of Norwalk virus, Sapporo virus and Human astrovirus in Pediatric Gastroenteritis in Hiroshima ...

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