Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Angiogenesis Inhibitors: Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.Leucovorin: The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Nasal Sprays: Pharmacologic agents delivered into the nostrils in the form of a mist or spray.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Glaucoma, Neovascular: A form of secondary glaucoma which develops as a consequence of another ocular disease and is attributed to the forming of new vessels in the angle of the anterior chamber.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Vitreous Body: The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Injections: Introduction of substances into the body using a needle and syringe.Intravitreal Injections: The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.Dihydrouracil Dehydrogenase (NADP): An oxidoreductase involved in pyrimidine base degradation. It catalyzes the catabolism of THYMINE; URACIL and the chemotherapeutic drug, 5-FLUOROURACIL.Epistaxis: Bleeding from the nose.Vitreous Hemorrhage: Hemorrhage into the VITREOUS BODY.Corneal Neovascularization: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.Organoplatinum Compounds: Organic compounds which contain platinum as an integral part of the molecule.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Thymidylate Synthase: An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Choroidal Neovascularization: A pathological process consisting of the formation of new blood vessels in the CHOROID.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Injections, Intraocular: The administration of substances into the eye with a hypodermic syringe.Benzalkonium Compounds: A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.Preservatives, Pharmaceutical: Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.Camptothecin: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.UracilFloxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Fluorescein Angiography: Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.Fluorodeoxyuridylate: 5-Fluoro-2'-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine.Visual Acuity: Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Colonic Neoplasms: Tumors or cancer of the COLON.Telangiectasia, Hereditary Hemorrhagic: An autosomal dominant vascular anomaly characterized by telangiectases of the skin and mucous membranes and by recurrent gastrointestinal bleeding. This disorder is caused by mutations of a gene (on chromosome 9q3) which encodes endoglin, a membrane glycoprotein that binds TRANSFORMING GROWTH FACTOR BETA.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.Tegafur: Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.Antimetabolites: Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Semustine: 4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Stomach Neoplasms: Tumors or cancer of the STOMACH.Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Rectal Neoplasms: Tumors or cancer of the RECTUM.DeoxycytidineLevamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Breast Neoplasms: Tumors or cancer of the human BREAST.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Infusions, Intra-Arterial: Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.Stomatitis: INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.Liver Neoplasms: Tumors or cancer of the LIVER.Levoleucovorin: A folate analog consisting of the pharmacologically active isomer of LEUCOVORIN.Bromouracil: 5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.Antidotes: Agents counteracting or neutralizing the action of POISONS.Drug Synergism: The action of a drug in promoting or enhancing the effectiveness of another drug.Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Chronotherapy: The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.Taxoids: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Prodrugs: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Phosphoribosyl Pyrophosphate: The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.LeukopeniaNeoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Mucositis: An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).Tomography, Optical Coherence: An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Thymidine Phosphorylase: An enzyme that catalyzes the transfer of 2-deoxy-D-ribose from THYMIDINE to orthophosphate, thereby liberating thymidine.Cytosine Deaminase: An enzyme which catalyzes the deamination of CYTOSINE resulting in the formation of URACIL. It can also act on 5-methylcytosine to form THYMIDINE.Drug Evaluation: Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Oxonic Acid: Antagonist of urate oxidase.Dihydropyrimidine Dehydrogenase Deficiency: An autosomal recessive disorder affecting DIHYDROPYRIMIDINE DEHYDROGENASE and causing familial pyrimidinemia. It is characterized by thymine-uraciluria in homozygous deficient patients. Even a partial deficiency in the enzyme leaves individuals at risk for developing severe 5-FLUOROURACIL-associated toxicity.Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Hepatic Artery: A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Deoxyuracil Nucleotides: Uracil nucleotides which contain deoxyribose as the sugar moiety.UridinePhosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.Interferon-alpha: One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.Uridine Phosphorylase: An enzyme that catalyzes the transfer of ribose from uridine to orthophosphate, forming uracil and ribose 1-phosphate.Maximum Tolerated Dose: The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Mitomycins: A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.Cell Line, Tumor: A cell line derived from cultured tumor cells.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.Deoxyuridine: 2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.Histidinol: The penultimate step in the pathway of histidine biosynthesis. Oxidation of the alcohol group on the side chain gives the acid group forming histidine. Histidinol has also been used as an inhibitor of protein synthesis.Antibiotics, Antineoplastic: Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Orotate Phosphoribosyltransferase: The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.ThiophenesFollow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Drug Screening Assays, Antitumor: Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Leukemia L1210Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Chemoradiotherapy: Treatment that combines chemotherapy with radiotherapy.Esophagogastric Junction: The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Trabeculectomy: Any surgical procedure for treatment of glaucoma by means of puncture or reshaping of the trabecular meshwork. It includes goniotomy, trabeculectomy, and laser perforation.Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.Thrombocytopenia: A subnormal level of BLOOD PLATELETS.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Infusions, Parenteral: The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.Nucleoside Deaminases: Catalyze the hydrolysis of nucleosides with the elimination of ammonia.beta-Alanine: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.Oxidoreductases: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Anus Neoplasms: Tumors or cancer of the ANAL CANAL.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.HT29 Cells: Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Fluoroacetates: Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall's Dictionary of Chemistry, 5th ed)Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Hematologic Diseases: Disorders of the blood and blood forming tissues.Hydroxyurea: An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.Pentosyltransferases: Enzymes of the transferase class that catalyze the transfer of a pentose group from one compound to another.
... , sold under the trade name Avastin, is medication used to treat a number of types of cancers and a specific eye ... and with 5-fluorouracil-based therapy for second-line metastatic colorectal cancer. It was approved by the EMA in January 2005 ...
Avastin), (2006) Oscillatory photodynamic therapy for choroidal neovascularization and central serous retinopathy; a pilot ... encapsulated 5-fluorouracil in the treatment of proliferative vitreoretinopathy (1988) Intravitreal liposome-encapsulated drugs ... Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates (1992) Cancer Therapy ...
Medienmitteilung: Roche erhält EU-Zulassung für Avastin in Kombination mit Tarceva bei Patienten mit einer bestimmten Form von ... fluorouracil, and leucovorin for metastatic colorectal cancer. In: The New England journal of medicine. Band 350, Nr. 23, Juni ... Juliane Ziegler, Doris Uhl: Avastin® nicht riskanter als Lucentis®. In: Deutsche Apothekerzeitung. 154, 39, Stuttgart, 25. ... a b c d e f g h i Fachinformation Avastin®, Juni 2017. ... FDA widerruft Avastin-Indikation bei Brustkrebs im Deutschen ...
Avastin - axilla - axillary artery - axillary bud - axillary dissection - axillary lymph node - axillary lymph node dissection ... fluorouracil - fluoxetine - flutamide - FOBT - folate - folate antagonist - FOLFOX - folic acid - follicular large cell ...
"Avastin, Thalomid, Taxotere, and Prednisone Effective for Men with Hormone Refractory Prostate Cancer". March 2010. Archived ... The initial regimen of cyclophosphamide and 5-fluorouracil was quickly joined by multiple regimens using a host of other ... "Chemotherapy of advanced prostatic carcinoma with cyclophosphamide or 5-fluorouracil: results of first national randomized ...
Avastin. Roche. Colorectal, lung, ovarian and brain cancer. 3. $6.56 billion. Trastuzumab. Herceptin. Roche. Breast, esophagus ... The fluoropyrimidines include fluorouracil and capecitabine. Fluorouracil is a nucleobase analogue that is metabolised in cells ... "Body Surface Area-based Dosing of 5-Fluorouracil Results in Extensive Interindividual Variability in 5-Fluorouracil Exposure in ... 5-fluorouracil, folinic acid, oxaliplatin. FOLFOX. There are a number of strategies in the administration of chemotherapeutic ...
"Avastin, Thalomid, Taxotere, and Prednisone Effective for Men with Hormone Refractory Prostate Cancer". March 2010. Archived ... The initial regimen of cyclophosphamide and 5-fluorouracil was quickly joined by multiple regimens using a host of other ... "Chemotherapy of advanced prostatic carcinoma with cyclophosphamide or 5-fluorouracil: results of first national randomized ...
"Avastin, Thalomid, Taxotere, and Prednisone Effective for Men with Hormone Refractory Prostate Cancer". March 2010. Archived ... The initial regimen of cyclophosphamide and 5-fluorouracil was quickly joined by multiple regimens using a host of other ... "Chemotherapy of advanced prostatic carcinoma with cyclophosphamide or 5-fluorouracil: results of first national randomized ...
... cyclophosphamide mitoxantrone fluorouracil, cyclophosphamide doxorubicin side effects, cyclophosphamide bowel cancer, tc ... renal cyclophosphamide recommended dose cyclophosphamide docetaxel combination cytoxan tooth decay cyclophosphamide and avastin ...
Experimental: Oxaliplatin + Fluorouracil + Leucovorin + Avastin Drug: Fluorouracil 300 mg/m^2 IV over 10 Minutes, then 600 mg/m ... Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, Leucovorin, and Avastin. The safety and scientific validity of this ... A Phase I Study of Hepatic Arterial Infusion of Oxaliplatin in Combination With Systemic Fluorouracil, Leucovorin and Avastin ... To study the highest tolerable dose of oxaliplatin used in combination with 5-fluorouracil, leucovorin, and Avastin® ( ...
Avastin, Fluorouracil, Doxorubicin and Streptozocin in Locally Advanced and Metastatic Pancreatic Endocrine Tumors. The safety ... Drug: Avastin Drug: Fluorouracil Drug: Doxorubicin Drug: Streptozocin Drug: Dexamethasone Drug: Ondansetron Phase 2 ... Open label, single-arm phase II study of avastin combined with fluorouracil, doxorubicin and streptozocin administered in 28- ... Phase II Study of Avastin, Fluorouracil, Doxorubicin and Streptozocin in Locally Advanced and Metastatic Pancreatic Endocrine ...
Avastin. 5-fluorouracil, Oxaliplatin, Leucovorin (FOLFOX). 5-fluorouracil, Irinotecan, Leucovorin (FOLFIRI). Additional ... Either 5-fluorouracil, Oxaliplatin, Leucovorin (FOLFOX) or 5-fluorouracil, Irinotecan, Leucovorin (FOLFIRI). ... Other Name: Avastin®. Drug: Standard Chemotherapy Each participant received one of the following chemotherapy regimens at the ... Other Name: Avastin®. Drug: Standard Chemotherapy Each participant received one of the following chemotherapy regimens at the ...
Other Name: Avastin®. Drug: 5-fluorouracil ( in FOLFOX) intravenous infusion. Other Name: 5-FU ... Drug: Cediranib Drug: Bevacizumab Drug: 5-fluorouracil ( in FOLFOX) Drug: Leucovorin (in FOLFOX) Drug: Oxaliplatin (in FOLFOX) ... Fluorouracil. Leucovorin. Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Physiological Effects of ... in Combination With 5-fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX), to the Efficacy of Bevacizumab in Combination With ...
BEVACIZUMAB (AVASTIN). *DEXAMETHASONE. *FLOXURIDINE. *FLUOROURACIL. *IRINOTECAN (CPT-11) CAMPTOSAR. *LEUCOVORIN. *OXALIPLATIN. ...
Fluorouracil; Avastin; Fluoxetine Hydrochloride; Flomax; Heparin; Lasix; Multi-Vitamin; Baclofen; Camptosar; Cefepime; ... Fluorouracil; Anzemet; Maxalt-MLT; Celebrex; Penicillin VK; Darvocet-N 50; Atenolol; Tamoxifen Citrate; Taxotere; Benadryl; ...
Avastin Dosage: unk Start date: 2010-11-01 End date: 2011-01-26 Fluorouracil Dosage: 500 mg, unk Start date: 2006-09-15 End ... Avastin Start date: 2010-08-01 End date: 2010-11-01 Avastin Start date: 2010-11-01 End date: 2011-01-26 Avastin Indication: ... Fluorouracil Indication: Breast Cancer Taxotere Indication: Breast Cancer Start date: 2006-11-01 End date: 2007-01-01 Avastin ... Avastin Dosage: unk Start date: 2010-03-26 End date: 2010-07-16 Xeloda Dosage: unk Administration route: Oral Start date: 2010- ...
Recurrence two years later first treated with 5-fluorouracil+leucovorin+oxaliplatin+bevacizumab (Avastin®). Follow-up CT-scan ... The above data is the doses normally used for Avastin® and are envisaged to be of the same order of magnitude for other VEGF- ... However, as pointed out above, the use of for example Avastin® requires a therapy in combination with cytostatic compounds to ... Furthermore, the use of for example Avastin®, have revealed a number of unwanted side-effects, when used as a combination ...
The latter is the current standard of care, combining leucovorin, fluorouracil, and irinotecan. ...
Metastatic colorectal cancer (mCRC) for first- or second-line treatment in combination with intravenous fluorouracil-based ... About Avastin® (bevacizumab) Avastin is a prescription-only medicine that is a solution for intravenous infusion. It is a ... Avastin, either in combination with carboplatin and paclitaxel or with carboplatin and gemcitabine, followed by Avastin alone, ... Ovarian cancer (OC). Avastin, in combination with carboplatin and paclitaxel, followed by Avastin alone, is used for the ...
Avastin. (Unk). *. Fluorouracil. (Unk). *. Elplat. (Unk). *. Magnesium Oxide. *. Calcium Levofolinate. (Unk). Although Euglucon ...
PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6 ... Other Name: Avastin. *Drug: mFOLFOX6 mFOLFOX6 regimen is a combination therapy of oxaliplatin (85 mg/m^2) administered as a 2- ... and 5-fluorouracil (5-FU) (2400 mg/m^2) administered on Day 1 of every 14-day cycle until disease progression, unacceptable ... followed by a loading dose of 5-fluorouracil (5-FU; 400 mg/m^2) IV bolus administered over approximately 2 to 4 minutes on Day ...
Read reports about chemotherapies by our users with Fluorouracil (5-FU), which involve terms such as chemo, day, days, effects ... Taxol, 5FU, Carboplatin, Avastin, Tarceva (withdrawn). During my 6 month treatment fatigue and nausea were the most consistent ... Fluorouracil (5-FU) Chemotherapy Chemotherapies. What Fluorouracil (5-FU) Chemotherapy Cancer Survivors said about their ... 4 bags of fluorouracil. Again, I was extremely lucky with side effects. None to speak of really and this time I didnt get the ...
Avastin - Prescribed for Glioblastoma Multiforme, Colorectal Cancer, Cervical Cancer, Non-Small Cell Lung Cancer, Renal Cell ... For Colorectal Cancer This is an extremely potent medication when used in combination with 5-Fluorouracil. My mum had a stage ... Avastin may... more Prescribed for Colorectal Cancer. oxaliplatin may also be used for purposes not listed in this medication ... For Glioblastoma Multiforme After my moms glioblastoma didnt respond to Temodar/radiation, she was put on Avastin, once every ...
Colorectal cancer, metastatic, in combination with fluorouracil-based chemotherapy (Avastin and bevacizumab biosimilar): IV: 5 ... Ovarian (epithelial), fallopian tube, or primary peritoneal cancer (Avastin only):. Stage III or IV disease, following initial ... Ovarian (epithelial), fallopian tube, or primary peritoneal cancer (platinum-resistant recurrent) (Avastin only): IV: 10 mg/kg ... Ovarian (epithelial), fallopian tube, or primary peritoneal cancer (platinum-sensitive recurrent) (Avastin only): IV: 15 mg/kg ...
Bevacizumab (Avastin, Mvasi) is given through a needle in a vein (intravenously) every 2 to 3 weeks. It is usually combined ... FOLFOX - leucovorin, 5-fluorouracil and oxaliplatin (Eloxatin). * CAPOX (also called XELOX) - capecitabine (Xeloda) and ... FOLFIRI - leucovorin (folinic acid), 5-fluorouracil (Adrucil, 5-FU) and irinotecan (Camptosar) ...
The recommended treatment is chemotherapy with 5-FU (5-fluorouracil) and oxaliplatin. This will be followed with Avastin ( ... With the recent advances in therapy for colon cancer and the use of newer agents such as Avastin (bevacizumab) and Erbitux ( ... I had a colon resection, followed by seven months of Xeloda (capecitabine), Avastin (bevacizumab) and oxaliplatin. I had a ... I went through 12 treatments of chemo - 5-FU (5-fluorouracil) with oxaliplatin - in case there were any microscopic cells. What ...
Indication(s): Metastatic colorectal cancer with intravenous 5-fluorouracil-based chemotherapy for first-or second-line ... based chemotherapy for second-line treatment in patients who have progressed on a first-line Avastin-containing regimen; ... followed by Avastin as a single agent ...
Bevacizumab (Avastin) is an example of targeted therapy. Target therapy inhibits the ability of tumors to make new blood ... Chemotherapy drugs commonly used for cervical cancer include cisplatin and 5-fluorouracil. Chemotherapy may also be the ...
About Avastin® (bevacizumab) Avastin is a prescription-only medicine that is a solution for intravenous infusion. It is a ... Metastatic colorectal cancer (mCRC) for first- or second-line treatment in combination with intravenous fluorouracil-based ... Avastin, either in combination with carboplatin and paclitaxel or with carboplatin and gemcitabine, followed by Avastin alone, ... Ovarian cancer (OC) - Avastin, in combination with carboplatin and paclitaxel, followed by Avastin alone, is used for the ...
Evidence-based recommendations on bevacizumab (Avastin) with oxaliplatin and fluorouracil plus folinic acid or capecitabine for ... Evidence-based recommendations on bevacizumab (Avastin) in combination with a taxane for the first-line treatment of metastatic ... Bevacizumab in combination with oxaliplatin and either fluorouracil plus folinic acid or capecitabine for the treatment of ... Evidence-based recommendations on cetuximab (Erbitux), bevacizumab (Avastin) and panitumumab (Vectibix) for treating metastatic ...
Evidence-based recommendations on bevacizumab (Avastin) with oxaliplatin and fluorouracil plus folinic acid or capecitabine for ... Evidence-based recommendations on bevacizumab (Avastin) in combination with a taxane for the first-line treatment of metastatic ... Bevacizumab in combination with oxaliplatin and either fluorouracil plus folinic acid or capecitabine for the treatment of ... Evidence-based recommendations on bevacizumab (Avastin) in combination with gemcitabine and carboplatin for treating the first ...
... fluorouracil, fu, leucovorin, nausea, neuropathy, oxaliplatin, sensitivity. You should be aware of these details written by ... which involve terms such as avastin, cold, effects, extreme, fatigue, ... avastincoldeffectsextremefatiguefluorouracilfuleucovorinnauseaneuropathyoxaliplatinsensitivity. ... Fluorouracil (5-fu), Oxaliplatin, Avastin, leucovorin. 1/15-3/2? Side effects - Extreme fatigue, nausea, cold sensitivity, ...
Should we get a 2nd opinion about this? The chemo regimen would be Fluorouracil or Adrucil, Leucovorin, Irinotecan, and Avastin ...
  • To view the Multimedia News Release, please click: http://www.prnewswire.com/mnr/roche/38590/ This is the first study to show clinical benefit for patients when combining Avastin with an anthracycline-containing regimen and Xeloda(R) (capecitabine), and the third trial (following E2100 and AVADO) to confirm the efficacy and safety of Avastin in combination with standard chemotherapies for the treatment of advanced breast cancer in the first line setting. (newswire.ca)
  • Oncology portfolio revenues rose 8% to CHF 20.7 billion, led by Avastin and other drugs such as Herceptin, MabThera/Rituxan, Tarceva and Xeloda. (bullfax.com)
  • The drug was being studied in a phase III trial in combination with Xeloda (capecitabine) or fluorouracil and cisplatin chemotherapy in patients with gastric cancer (stomach cancer). (bullfax.com)
  • Intraveneus 5-FU of oraal 5-FU (capecitabine - xeloda) gecombineerd met radiotherapie - bestraling van het bekken geeft dezelfde uitkomsten op ziektevrije tijd, progressievrije tijd en overall overleving. (kanker-actueel.nl)
  • Omdat bij xeloda geen catheters en infuus moet worden gebruikt kan dit de nieuwe vorm van behandeling worden. (kanker-actueel.nl)
  • De onderzoekers deelden gerandomiseerd 1137 patiënten met KRAS wild-type (codons 12 en 13) onbehandelde uitgezaaide darmkanker in naar chemotherpaie plus bevacizumab - Avastin (5 mg/kg bij aanvang en daarna iedere twee weken) of cetuximab (een startende dosis van 400 mg/m² gevolgd door 250 mg/m² een keer per week). (kanker-actueel.nl)
  • Tecentriq in combination with Avastin could transform the treatment of this aggressive disease, and we are working closely with global health authorities in the hope of bringing this treatment option to patients as soon as possible. (businesswire.com)
  • A significant increase in tumour shrinkage in patients that received Avastin (response rate = 51% vs. 37.9% for Avastin + anthracycline or taxane chemotherapy vs. chemotherapy alone). (newswire.ca)
  • These results are further proof that Avastin based therapy is part of the armamentarium of treatment for patients with advanced breast cancer' said Dr Nicholas Robert, M.D, Co-chair Breast Cancer Research Committee, U.S. Oncology, Inc., investigator of the RIBBON-1 study. (newswire.ca)
  • The growing body of evidence supporting the combination of Avastin with commonly used chemotherapy regimens, gives physicians more flexibility to tailor the most appropriate course of Avastin based therapy for their patients. (newswire.ca)
  • More than 500,000 patients have been treated with Avastin so far. (newswire.ca)
  • The safety of long-term treatment with Avastin has been evaluated in patients and in animals. (aacrjournals.org)
  • Treatment of patients with Avastin has been associated with an increased incidence of hemorrhage, hypertension, thromboembolic events, proteinuria, congestive heart failure, and impaired wound healing. (aacrjournals.org)
  • On account of the lack of predictive biomarkers of toxicity, we investigated whether polymorphisms of genes involved in fluoropyrimidine metabolism and 5-fluorouracil (5-FU) degradation rate were associated with outcomes of adjuvant capecitabine in patients with early stage gastrointestinal cancers. (cancerindex.org)
  • A total of 30 eyes (15 in each group) in patients above 40 years of age with primary glaucoma, underwent trabeculectomy with 5-Fluorouracil (5-FU) (50 mg/ml) applied for 5 minutes. (org.pk)
  • Gastrointestinal Perforation: Occurs in up to 2.4% of Avastin‑treated patients. (drugsdb.eu)
  • Hemorrhage: Severe or fatal hemorrhage, hemoptysis, gastrointestinal bleeding, CNS hemorrhage, and vaginal bleeding are increased in Avastin‑ treated patients. (drugsdb.eu)
  • The approval is based on positive results from the Phase III ML18147 study, which were presented at the 2012 American Society of Clinical Oncology annual meeting and showed that people who continued to receive an Avastin-based regimen after their cancer worsened lived longer than people who switched to chemotherapy alone. (newswiretoday.com)
  • Discontinue Avastin for gastrointestinal perforation. (drugsdb.eu)
  • Non‑Gastrointestinal Fistula Formation: Discontinue Avastin if fistula formation occurs. (drugsdb.eu)
  • Arterial Thromboembolic Events (e.g., myocardial infarction, cerebral infarction): Discontinue Avastin for severe ATE. (drugsdb.eu)
  • Discontinue Avastin for hypertensive crisis or hypertensive encephalopathy. (drugsdb.eu)
  • Reversible Posterior Leukoencephalopathy Syndrome (RPLS): Discontinue Avastin. (drugsdb.eu)
  • For Glioblastoma Multiforme diagnosed with brain cancer four years ago at age 32, Surgery, Temodar and radiation worked for first couple years, then I got two more tumors, stopped Temodar and started Avastin. (drugs.com)
  • I'm 62 had adenocarcinoma in 2011 IIIc and got better for 2.5 yrsuntil my CEA went from 1.4 to 33 & my onc jumped on the folfuri with avastin - I doget a shot of atropine before the biweekly chemo along with 2 anti anti nausea meds - but I've got no issues. (navigatingcare.com)
  • In oncoline staat in de richtlijnen beschreven dat chemo bij darmkanker stadium II controversieel en niet bewezen effectief is en in principe wordt overgelaten aan de behandelend arts en de situatie van de individuele patiënt. (kanker-actueel.nl)
  • Toch weten wij uit ervaring dat bijna elke darmkankerpatiënt zelfs bij geen gevonden uitzaaiïngen en succesvollle operatie in heel veel gevallen chemo krijgt als behandeling. (kanker-actueel.nl)
  • En wederom is dus nu aangetoond dat intraveneus toegediende chemo bij darmkanker stadium II en bij ouderen in alle stadia geen enkele meerwaarde heeft. (kanker-actueel.nl)
  • My husband did 5fu with Avastin and had good results (rectal tumor with many mets to liver). (cancer.org)
  • MUMBAI: Swiss biotechnology giant Roche has sued the Drug Controller General of India in Delhi High Court along with Hyderabad-based Hetero Drugs over the process followed for approval of copies of complex biotech drugs or biosimilars of Avastin (bevacizumab), its blockbuster brand that is used to treat at least six forms of advanced cancers. (bullfax.com)