The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery.
The removal or interruption of some part of the autonomic nervous system for therapeutic or research purposes.
The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
Nerves and plexuses of the autonomic nervous system. The central nervous system structures which regulate the autonomic nervous system are not included.
Agents affecting the function of, or mimicking the actions of, the autonomic nervous system and thereby having an effect on such processes as respiration, circulation, digestion, body temperature regulation, certain endocrine gland secretions, etc.
A change in electrical resistance of the skin, occurring in emotion and in certain other conditions.
Interruption of sympathetic pathways, by local injection of an anesthetic agent, at any of four levels: peripheral nerve block, sympathetic ganglion block, extradural block, and subarachnoid block.
Irregular HEART RATE caused by abnormal function of the SINOATRIAL NODE. It is characterized by a greater than 10% change between the maximum and the minimum sinus cycle length or 120 milliseconds.
Biological actions and events that support the functions of the CARDIOVASCULAR SYSTEM.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.
A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.
The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
An autosomal disorder of the peripheral and autonomic nervous systems limited to individuals of Ashkenazic Jewish descent. Clinical manifestations are present at birth and include diminished lacrimation, defective thermoregulation, orthostatic hypotension (HYPOTENSION, ORTHOSTATIC), fixed pupils, excessive SWEATING, loss of pain and temperature sensation, and absent reflexes. Pathologic features include reduced numbers of small diameter peripheral nerve fibers and autonomic ganglion neurons. (From Adams et al., Principles of Neurology, 6th ed, p1348; Nat Genet 1993;4(2):160-4)
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
The hollow, muscular organ that maintains the circulation of the blood.
The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.
A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.
Processes and properties of the CARDIOVASCULAR SYSTEM as a whole or of any of its parts.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
The removal or interruption of some part of the parasympathetic nervous system for therapeutic or research purposes.
Forced expiratory effort against a closed GLOTTIS.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
Clusters of neurons and their processes in the autonomic nervous system. In the autonomic ganglia, the preganglionic fibers from the central nervous system synapse onto the neurons whose axons are the postganglionic fibers innervating target organs. The ganglia also contain intrinsic neurons and supporting cells and preganglionic fibers passing through to other ganglia.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
A nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.
The systematic and methodical manipulations of body tissues best performed with the hands for the purpose of affecting the nervous and muscular systems and the general circulation.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
A reduction in the amount of air entering the pulmonary alveoli.
Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.
The study of the physiological basis of human and animal behavior.
A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.
A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)
Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
A type of impedance plethysmography in which bioelectrical impedance is measured between electrodes positioned around the neck and around the lower thorax. It is used principally to calculate stroke volume and cardiac volume, but it is also related to myocardial contractility, thoracic fluid content, and circulation to the extremities.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The posture of an individual lying face up.
Activity which reduces the feelings of tension and the effects of STRESS, PHYSIOLOGICAL.
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Elements of limited time intervals, contributing to particular results or situations.
A standard and widely accepted diagnostic test used to identify patients who have a vasodepressive and/or cardioinhibitory response as a cause of syncope. (From Braunwald, Heart Disease, 7th ed)
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
An adjunctive treatment for PARTIAL EPILEPSY and refractory DEPRESSION that delivers electrical impulses to the brain via the VAGUS NERVE. A battery implanted under the skin supplies the energy.
Stress wherein emotional factors predominate.
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
The hemodynamic and electrophysiological action of the HEART ATRIA.
Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The biochemical and electrophysiological interactions between the NERVOUS SYSTEM and IMMUNE SYSTEM.
The measurement of magnetic fields generated by electric currents from the heart. The measurement of these fields provides information which is complementary to that provided by ELECTROCARDIOGRAPHY.
Transmission of the readings of instruments to a remote location by means of wires, radio waves, or other means. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Nerve fibers liberating catecholamines at a synapse after an impulse.
Posture while lying with the head lower than the rest of the body. Extended time in this position is associated with temporary physiologic disturbances.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
The removal or interruption of some part of the sympathetic nervous system for therapeutic or research purposes.
Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system.
The heart rate of the FETUS. The normal range at term is between 120 and 160 beats per minute.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
Benign and malignant neoplastic processes arising from or involving components of the central, peripheral, and autonomic nervous systems, cranial nerves, and meninges. Included in this category are primary and metastatic nervous system neoplasms.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The number of times an organism breathes with the lungs (RESPIRATION) per unit time, usually per minute.
Neurons whose primary neurotransmitter is EPINEPHRINE.
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
Drugs that bind to and activate adrenergic receptors.
A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.
Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.
Compounds containing the hexamethylenebis(trimethylammonium) cation. Members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
Agents that mimic neural transmission by stimulation of the nicotinic receptors on postganglionic autonomic neurons. Drugs that indirectly augment ganglionic transmission by increasing the release or slowing the breakdown of acetylcholine or by non-nicotinic effects on postganglionic neurons are not included here nor are the nonspecific cholinergic agonists.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Nerve fibers which project from sympathetic ganglia to synapses on target organs. Sympathetic postganglionic fibers use norepinephrine as transmitter, except for those innervating eccrine sweat glands (and possibly some blood vessels) which use acetylcholine. They may also release peptide cotransmitters.
A form of acupuncture with electrical impulses passing through the needles to stimulate NERVE TISSUE. It can be used for ANALGESIA; ANESTHESIA; REHABILITATION; and treatment for diseases.
An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased, decreased, or absent reflexes.
The major nerves supplying sympathetic innervation to the abdomen. The greater, lesser, and lowest (or smallest) splanchnic nerves are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses. The lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
The period of time following the triggering of an ACTION POTENTIAL when the CELL MEMBRANE has changed to an unexcitable state and is gradually restored to the resting (excitable) state. During the absolute refractory period no other stimulus can trigger a response. This is followed by the relative refractory period during which the cell gradually becomes more excitable and the stronger impulse that is required to illicit a response gradually lessens to that required during the resting state.
Sense of awareness of self and of the environment.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
The position or attitude of the body.
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
The resection or removal of the nerve to an organ or part. (Dorland, 28th ed)
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.
Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.
A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)
Physiological processes and properties of the RESPIRATORY SYSTEM as a whole or of any of its parts.
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
The TEMPERATURE at the outer surface of the body.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
The functions of the skin in the human and animal body. It includes the pigmentation of the skin.
The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.
A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
Nerve fibers liberating acetylcholine at the synapse after an impulse.
A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.
Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.
The aperture in the iris through which light passes.
Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.
The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)
The motor activity of the GASTROINTESTINAL TRACT.
A characteristic symptom complex.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.
Freedom from activity.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
Loss of consciousness due to a reduction in blood pressure that is associated with an increase in vagal tone and peripheral vasodilation.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Analysis based on the mathematical function first formulated by Jean-Baptiste-Joseph Fourier in 1807. The function, known as the Fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the x-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerized tomography imaging, etc. (From Segen, The Dictionary of Modern Medicine, 1992)
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252)
Glucose in blood.
A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
Use of electric potential or currents to elicit biological responses.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.
The chambers of the heart, to which the BLOOD returns from the circulation.
The processes whereby the internal environment of an organism tends to remain balanced and stable.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).
MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
A continuing periodic change in displacement with respect to a fixed reference. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Methods to induce and measure electrical activities at specific sites in the heart to diagnose and treat problems with the heart's electrical system.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3....) that are characterized by their cellular actions, pharmacology, and molecular biology.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An absence of warmth or heat or a temperature notably below an accustomed norm.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Those affective states which can be experienced and have arousing and motivational properties.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Recording of the changes in electric potential of muscle by means of surface or needle electrodes.
Drugs that selectively bind to and activate alpha adrenergic receptors.
The study of systems which respond disproportionately (nonlinearly) to initial conditions or perturbing stimuli. Nonlinear systems may exhibit "chaos" which is classically characterized as sensitive dependence on initial conditions. Chaotic systems, while distinguished from more ordered periodic systems, are not random. When their behavior over time is appropriately displayed (in "phase space"), constraints are evident which are described by "strange attractors". Phase space representations of chaotic systems, or strange attractors, usually reveal fractal (FRACTALS) self-similarity across time scales. Natural, including biological, systems often display nonlinear dynamics and chaos.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.

Central autonomic activation by intracisternal TRH analogue excites gastric splanchnic afferent neurons. (1/2230)

Intracisternal (ic) injection of thyrotropin-releasing hormone (TRH) or its stable analogue RX 77368 influences gastric function via stimulation of vagal muscarinic pathways. In rats, the increase in gastric mucosal blood flow evoked by a low ic dose of RX 77368 occurs via release of calcitonin gene-related peptide from capsaicin-sensitive afferent neurons, most probably of spinal origin. In this study, the effect of low ic doses of RX 77368 on afferent impulse activity in splanchnic single fibers was investigated. The cisterna magna of overnight-fasted, urethan-anesthetized Sprague-Dawley rats was acutely cannulated, and fine splanchnic nerve twigs containing at least one fiber responsive to mechanical probing of the stomach were isolated at a site immediately distal to the left suprarenal ganglion. Unit mechanoreceptive fields were encountered in all portions of the stomach, both superficially and in deeper layers. Splanchnic afferent unit impulse activity was recorded continuously during basal conditions and in response to consecutive ic injections of saline and RX 77368 (15-30 min later; 1.5 or 3 ng). Basal discharge rates ranged from 0 to 154 impulses/min (median = 10.2 impulses/min). A majority of splanchnic single units with ongoing activity increased their mean discharge rate by >/=20% after ic injection of RX 77368 at either 1.5 ng (6/10 units; median increase 63%) or 3 ng (19/24 units; median increase 175%). Five units lacking impulse activity in the 5-min before ic RX 77368 (3 ng) were also excited, with the onset of discharge occurring within 1.0-5.0 min postinjection. In units excited by ic RX 77368, peak discharge occurred 15.6 +/- 1.3 min after injection and was followed by a decline to stable activity levels +info)

Pharmacodynamic actions of (S)-2-[4,5-dihydro-5-propyl-2-(3H)-furylidene]-1,3-cyclopentanedione (oudenone). (2/2230)

The pharmacodynamic actions of (S)-2-[4,5-dihydro-5-propyl-2(3H)-furylidene]-1,3-cyclopentanedione (oudenone) were studied in both anesthetized animals and isolated organs. Oudenone (10--40 mg/kg i.v.) induced an initial rise in blood pressure followed by a prolonged hypotension in the anesthetized rats. In unanesthetized spontaneously hypertensive rats (SHR), oudenone (5--200 mg/kg p.o.) caused a dose-related decrease in the systolic blood pressure. The initial pressor effect was diminished by pretreatments with phentolamine, guanethidine, hexamethonium and was abolished in the pithed rats. In addition, intracisternal administrations of oudenone (100--600 mug/kg) showed a marked increase in blood pressure in the anesthetized rats, suggesting that the pressor effect may be due to centrally mediated actions. Oudenone, given intra-arterially into the femoral artery (400--800 mug/kg), caused a long-lasting vasodilation in anesthetized dogs. At a relatively high dose (40 mg/kg i.v.), oudenone antagonized all pressor responses to autonomic agents and central vagus nerve stimulation in anesthetized rats and dogs, however, oudenone showed no anti-cholinergic,-histaminergic, beta-adrenergic and adrenergic neuron blocking properties.  (+info)

Differences in heart rate variability between young and elderly normal men during graded head up tilt. (3/2230)

An autoregressive spectral analysis of heart rate variability (HRV) was used to analyze the differences in autonomic functions during graded head up tilt (HUT) between young and elderly men. After recording at the 0 degree position, the table was rotated to an upright position. The incline of the table was increased progressively to 15 degrees, 30 degrees and 60 degrees. The data obtained from seven young subjects (mean age of 20.0 years) and nine elderly subjects (mean age of 63.3 years) were analyzed. The high frequency components expressed by normalized units (HFnu) were used as the parasympathetic indicators, and HFnu decreased with tilt angle in both age groups. These results suggested that parasympathetic withdrawal have an important role in adaptation to an upright posture in both age groups. However, mean HF amplitude at the 0 degree position in elderly men was not significantly different from that of young men at 60 degrees tilt. A significant interaction effect (age group x tilt angle) was found for mean HF amplitude. The increase of the low frequency components expressed by normalized units (LFnu) and the LF-to-HF ratio in elderly subjects from 0 degree to 15 degrees seemed to be larger than that in young subjects. Sympathetic activities may be sensitive to lower levels of orthostatic stress in the elderly, and the elderly workers are easily affected by a change in workload. Therefore, keeping the workload lower and constant may be recommended to avoid excessive sympathetic activation among the elderly.  (+info)

Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. (4/2230)

BACKGROUND: The chemoreflexes are an important mechanism for regulation of both breathing and autonomic cardiovascular function. Abnormalities in chemoreflex mechanisms may be implicated in increased cardiovascular stress in patients with obstructive sleep apnea (OSA). We tested the hypothesis that chemoreflex function is altered in patients with OSA. METHODS AND RESULTS: We compared ventilatory, sympathetic, heart rate, and blood pressure responses to hypoxia, hypercapnia, and the cold pressor test in 16 untreated normotensive patients with OSA and 12 normal control subjects matched for age and body mass index. Baseline muscle sympathetic nerve activity (MSNA) was higher in the patients with OSA than in the control subjects (43+/-4 versus 21+/-3 bursts per minute; P<0. 001). During hypoxia, patients with OSA had greater increases in minute ventilation (5.8+/-0.8 versus 3.2+/-0.7 L/min; P=0.02), heart rate (10+/-1 versus 7+/-1 bpm; P=0.03), and mean arterial pressure (7+/-2 versus 0+/-2 mm Hg; P=0.001) than control subjects. Despite higher ventilation and blood pressure (both of which inhibit sympathetic activity) in OSA patients, the MSNA increase during hypoxia was similar in OSA patients and control subjects. When the sympathetic-inhibitory influence of breathing was eliminated by apnea during hypoxia, the increase in MSNA in OSA patients (106+/-20%) was greater than in control subjects (52+/-23%; P=0.04). Prolongation of R-R interval with apnea during hypoxia was also greater in OSA patients (24+/-6%) than in control subjects (7+/-5%) (P=0.04). Autonomic, ventilatory, and blood pressure responses to hypercapnia and the cold pressor test in OSA patients were not different from those observed in control subjects. CONCLUSIONS: OSA is associated with a selective potentiation of autonomic, hemodynamic, and ventilatory responses to peripheral chemoreceptor activation by hypoxia.  (+info)

Differential effects of defibrillation on systemic and cardiac sympathetic activity. (5/2230)

OBJECTIVE: To assess the effect of defibrillation shocks on cardiac and circulating catecholamines. DESIGN: Prospective examination of myocardial catecholamine balance during dc shock by simultaneous determination of arterial and coronary sinus plasma concentrations. Internal countershocks (10-34 J) were applied in 30 patients after initiation of ventricular fibrillation for a routine implantable cardioverter defibrillator test. Another 10 patients were externally cardioverted (50-360 J) for atrial fibrillation. MAIN OUTCOME MEASURES: Transcardiac noradrenaline, adrenaline, and lactate gradients immediately after the shock. RESULTS: After internal shock, arterial noradrenaline increased from a mean (SD) of 263 (128) pg/ml at baseline to 370 (148) pg/ml (p = 0.001), while coronary sinus noradrenaline fell from 448 (292) to 363 (216) pg/ml (p = 0.01), reflecting a shift from cardiac net release to net uptake. After external shock delivery, there was a similar increase in arterial noradrenaline, from 260 (112) to 459 (200) pg/ml (p = 0.03), while coronary sinus noradrenaline remained unchanged. Systemic adrenaline increased 11-fold after external shock (p = 0.01), outlasting the threefold rise following internal shock (p = 0.001). In both groups, a negative transmyocardial adrenaline gradient at baseline decreased further, indicating enhanced myocardial uptake. Cardiac lactate production occurred after ventricular fibrillation and internal shock, but not after external cardioversion, so the neurohumoral changes resulted from the defibrillation process and not from alterations in oxidative metabolism. CONCLUSIONS: A dc shock induces marked systemic sympathoadrenal and sympathoneuronal activation, but attenuates cardiac sympathetic activity. This might promote the transient myocardial depression observed after electrical discharge to the heart.  (+info)

Lateralized effects of medial prefrontal cortex lesions on neuroendocrine and autonomic stress responses in rats. (6/2230)

The medial prefrontal cortex (mPFC) is highly activated by stress and modulates neuroendocrine and autonomic function. Dopaminergic inputs to mPFC facilitate coping ability and demonstrate considerable hemispheric functional lateralization. The present study investigated the potentially lateralized regulation of stress responses at the level of mPFC output neurons, using ibotenic acid lesions. Neuroendocrine function was assessed by plasma corticosterone increases in response to acute or repeated 20 min restraint stress. The primary index of autonomic activation was gastric ulcer development during a separate cold restraint stress. Restraint-induced defecation was also monitored. Plasma corticosterone levels were markedly lower in response to repeated versus acute restraint stress. In acutely restrained animals, right or bilateral, but not left mPFC lesions, decreased prestress corticosterone levels, whereas in repeatedly restrained rats, the same lesions significantly reduced the peak stress-induced corticosterone response. Stress ulcer development (after a single cold restraint stress) was greatly reduced by either right or bilateral mPFC lesions but was unaffected by left lesions. Restraint-induced defecation was elevated in animals with left mPFC lesions. Finally, a left-biased asymmetry in adrenal gland weights was observed across animals, which was unaffected by mPFC lesions. The results suggest that mPFC output neurons demonstrate an intrinsic right brain specialization in both neuroendocrine and autonomic activation. Such findings may be particularly relevant to clinical depression which is associated with both disturbances in stress regulatory systems and hemispheric imbalances in prefrontal function.  (+info)

Noninvasive exploration of cardiac autonomic neuropathy. Four reliable methods for diabetes? (7/2230)

OBJECTIVE: The purpose of this work was to assess relevant information that could be provided by various mathematical analyses of spontaneous blood pressure (BP) and heart rate (HR) variabilities in diabetic cardiovascular neuropathy. RESEARCH DESIGN AND METHODS: There were 10 healthy volunteers and 11 diabetic subjects included in the study. Diabetic patients were selected for nonsymptomatic orthostatic hypotension in an assessment of their cardiovascular autonomic impairment. Cardiac autonomic function was scored according to Ewing's methodology adapted to the use of a Finapres device. The spontaneous beat-to-beat BP and HR variabilities were then analyzed on a 1-h recording in supine subjects. The global variabilities were assessed by standard deviation, fractal dimension, and spectral power. The cardiac baroreflex function was estimated by cross-spectral sequences and Z analyses. RESULTS: In diabetic patients, Ewing's scores ranged from 1 to 4.5, confirming cardiovascular autonomic dysfunction. In these diabetic patients, global indices of variabilities were consistently lower than in healthy subjects. Furthermore, some of them (standard deviation and fractal dimension of HR, spectral power of systolic blood pressure and HR) were significantly correlated with the Ewing's scores. The Z methods and the spectral analysis found that the cardiac baroreflex was less effective in diabetic subjects. However, the baroreflex sensitivity could not be reliably assessed in all the patients. The sequence method pointed out a decreased number of baroreflex sequences in diabetic subjects that was correlated to the Ewing's score. CONCLUSIONS: Indices of HR spontaneous beat-to-beat variability are consistently related to the degree of cardiac autonomic dysfunction, according to Ewing's methodology. The Z method and spectral analysis confirmed that the cardiac baroreflex was impaired in diabetic patients. These methods might be clinically relevant for use in detecting incipient neuropathy in diabetic patients.  (+info)

Detection of autonomic sympathetic dysfunction in diabetic patients. A study using laser Doppler imaging. (8/2230)

OBJECTIVE: To study signs of the disturbed reflex autonomic sympathetic nerve function in type 1 and type 2 diabetic patients. RESEARCH DESIGN AND METHODS: Measurements were made on 15 type 1 (duration 13-32 years) and on 50 recently diagnosed type 2 diabetic patients (duration 3-4 years). The vasoconstrictor responses in the distal phalanx of the middle finger (locally heated to 40 degrees C) to the cooling of the contralateral arm were measured using Laser Doppler Imaging (LDI). A vasoconstriction index (VAC) was calculated taking age into account and was compared with reference values obtained in 80 control subjects. The diabetic patients were also studied with deep-breathing tests (i.e., the heart-rate variation expressed as the expiration-to-inspiration [E/I] ratio, a test of parasympathetic nerve function). RESULTS: The vasoconstrictor responses to indirect cooling (VAC) were significantly reduced in the fingers of the diabetic patients, both type 2 (0.77 +/- 0.02 V; P < 0.01) and type 1 (0.83 +/- 0.04 V; P < 0.001), compared with the healthy control subjects (0.65 +/- 0.01); the age-corrected VAC (VACz) was slightly more impaired in type 1 than in type 2 diabetic patients. The frequency of an abnormal VACz corresponded well to the frequency of an abnormal E/I ratio in type 1 diabetic patients (approximately 50%), whereas the frequency of an abnormal VACz was significantly higher than an abnormal E/I ratio among type 2 diabetic patients (11/50 vs. 4/50; P < 0.05). CONCLUSIONS: Both type 1 and type 2 diabetic patients have impaired cutaneous blood flow regulation. The VAC index seems to be a promising tool for detection of subclinical changes in autonomic sympathetic function.  (+info)

There are many different types of ANS diseases, including:

1. Dysautonomia: a general term that refers to dysfunction of the autonomic nervous system.
2. Postural orthostatic tachycardia syndrome (POTS): a condition characterized by rapid heart rate and other symptoms that occur upon standing.
3. Neurocardiogenic syncope: a form of fainting caused by a sudden drop in blood pressure.
4. Multiple system atrophy (MSA): a progressive neurodegenerative disorder that affects the autonomic nervous system and other parts of the brain.
5. Parkinson's disease: a neurodegenerative disorder that can cause autonomic dysfunction, including constipation, urinary incontinence, and erectile dysfunction.
6. Dopamine deficiency: a condition characterized by low levels of the neurotransmitter dopamine, which can affect the ANS and other body systems.
7. Autonomic nervous system disorders associated with autoimmune diseases, such as Guillain-Barré syndrome and lupus.
8. Trauma: physical or emotional trauma can sometimes cause dysfunction of the autonomic nervous system.
9. Infections: certain infections, such as Lyme disease, can affect the autonomic nervous system.
10. Genetic mutations: some genetic mutations can affect the functioning of the autonomic nervous system.

Treatment for ANS diseases depends on the specific condition and its underlying cause. In some cases, medication may be prescribed to regulate heart rate, blood pressure, or other bodily functions. Lifestyle changes, such as regular exercise and stress management techniques, can also be helpful in managing symptoms. In severe cases, surgery may be necessary to correct anatomical abnormalities or repair damaged nerves.

When the sinus node is not functioning properly, it can lead to an arrhythmia, or irregular heartbeat. This can cause a variety of symptoms, including palpitations, shortness of breath, fatigue, and dizziness. In some cases, sinus arrhythmia can be caused by underlying medical conditions such as coronary artery disease, high blood pressure, or cardiomyopathy.

There are several types of sinus arrhythmia, including:

* Sinus tachycardia: a rapid heart rate due to an overactive sinus node. This can be caused by stress, anxiety, or physical exertion.
* Sinus bradycardia: a slow heart rate due to a decreased activity in the sinus node. This can be caused by certain medications, age, or underlying medical conditions.
* Sinus arrest: a complete cessation of sinus node activity, leading to a stop in the heartbeat. This is a rare condition and can be caused by a variety of factors, including electrolyte imbalances or certain medications.

Treatment for sinus arrhythmia depends on the underlying cause and the severity of symptoms. In some cases, no treatment may be necessary, while in other cases, medication or procedures such as cardioversion or catheter ablation may be required. It is important to seek medical attention if symptoms persist or worsen over time, as untreated sinus arrhythmia can lead to more serious complications such as stroke or heart failure.

1. Neurodegenerative diseases: These are diseases that cause progressive loss of brain cells, leading to cognitive decline and motor dysfunction. Examples include Alzheimer's disease, Parkinson's disease, and Huntington's disease.
2. Stroke: A stroke occurs when blood flow to the brain is interrupted, leading to cell death and potential long-term disability.
3. Traumatic brain injury: This type of injury occurs when the brain is subjected to a sudden and forceful impact, such as in a car accident or fall.
4. Infections: Bacterial, viral, and fungal infections can all cause CNS diseases, such as meningitis and encephalitis.
5. Autoimmune disorders: These are conditions in which the immune system mistakenly attacks healthy cells in the brain, leading to inflammation and damage. Examples include multiple sclerosis and lupus.
6. Brain tumors: Tumors can occur in any part of the brain and can be benign or malignant.
7. Cerebrovascular diseases: These are conditions that affect the blood vessels in the brain, such as aneurysms and arteriovenous malformations (AVMs).
8. Neurodevelopmental disorders: These are conditions that affect the development of the brain and nervous system, such as autism spectrum disorder and attention deficit hyperactivity disorder (ADHD).

CNS diseases can have a significant impact on quality of life, and some can be fatal. Treatment options vary depending on the specific diagnosis and severity of the disease. Some CNS diseases can be managed with medication, while others may require surgery or other interventions.

Some of the symptoms of familial dysautonomia are similar to those found in other types of dysautonomia, such as difficulty regulating body temperature, blood pressure changes, and gastrointestinal disturbances. However, people with familial dysautonomia may also experience additional signs and symptoms that are unique to the condition.

Research has identified several genetic mutations or variations that can cause familial dysautonomia. These include:

1. Mutations in the EDNRB gene, which codes for the dopamine receptor beta subunit. This gene is important for regulating the activity of the autonomic nervous system.
2. Variations in the THAP11 gene, which codes for a protein that plays a role in the development and function of the autonomic nervous system.
3. Mutations in the KCNQ2 and KCNQ3 genes, which code for potassium channels that are important for regulating the activity of the autonomic nervous system.

Familial dysautonomia is a rare condition, and it can be difficult to diagnose because its symptoms can be similar to those of other conditions. However, a diagnosis may be made based on a combination of clinical findings, genetic testing, and the exclusion of other potential causes of the symptoms.

There is no cure for familial dysautonomia, but treatment options are available to help manage the symptoms. These may include medications to regulate blood pressure or heart rate, therapies to improve gastrointestinal function, and measures to prevent complications such as dehydration or heat stroke. In addition, individuals with familial dysautonomia may need to make lifestyle adjustments to accommodate their condition, such as avoiding extreme temperatures or taking regular breaks to rest.

Familial dysautonomia is a rare and complex condition that can have a significant impact on quality of life. However, with proper management and support, individuals with this condition can lead fulfilling lives.

Benign CNS neoplasms include:

1. Meningiomas: These are the most common type of benign CNS tumor, arising from the meninges (the membranes covering the brain and spinal cord).
2. Acoustic neuromas: These tumors arise from the nerve cells that connect the inner ear to the brain.
3. Pineal gland tumors: These are rare tumors that occur in the pineal gland, a small gland located in the brain.
4. Craniopharyngiomas: These are rare tumors that arise from the remnants of the embryonic pituitary gland and can cause a variety of symptoms including headaches, vision loss, and hormonal imbalances.

Malignant CNS neoplasms include:

1. Gliomas: These are the most common type of malignant CNS tumor and arise from the supporting cells of the brain called glial cells. Examples of gliomas include astrocytomas, oligodendrogliomas, and medulloblastomas.
2. Lymphomas: These are cancers of the immune system that can occur in the CNS.
3. Melanomas: These are rare tumors that arise from the pigment-producing cells of the skin and can spread to other parts of the body, including the CNS.
4. Metastatic tumors: These are tumors that have spread to the CNS from other parts of the body, such as the breast, lung, or colon.

The diagnosis and treatment of central nervous system neoplasms depend on the type, size, location, and severity of the tumor, as well as the patient's overall health and medical history. Treatment options can include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy.

The prognosis for CNS neoplasms varies depending on the type of tumor and the effectiveness of treatment. In general, gliomas have a poorer prognosis than other types of CNS tumors, with five-year survival rates ranging from 30% to 60%. Lymphomas and melanomas have better prognoses, with five-year survival rates of up to 80%. Metastatic tumors have a more guarded prognosis, with five-year survival rates depending on the primary site of the cancer.

In summary, central nervous system neoplasms are abnormal growths of tissue in the brain and spinal cord that can cause a variety of symptoms and can be benign or malignant. The diagnosis and treatment of these tumors depend on the type, size, location, and severity of the tumor, as well as the patient's overall health and medical history. The prognosis for CNS neoplasms varies depending on the type of tumor and the effectiveness of treatment, but in general, gliomas have a poorer prognosis than other types of CNS tumors.

There are many different types of cardiac arrhythmias, including:

1. Tachycardias: These are fast heart rhythms that can be too fast for the body's needs. Examples include atrial fibrillation and ventricular tachycardia.
2. Bradycardias: These are slow heart rhythms that can cause symptoms like fatigue, dizziness, and fainting. Examples include sinus bradycardia and heart block.
3. Premature beats: These are extra beats that occur before the next regular beat should come in. They can be benign but can also indicate an underlying arrhythmia.
4. Supraventricular arrhythmias: These are arrhythmias that originate above the ventricles, such as atrial fibrillation and paroxysmal atrial tachycardia.
5. Ventricular arrhythmias: These are arrhythmias that originate in the ventricles, such as ventricular tachycardia and ventricular fibrillation.

Cardiac arrhythmias can be diagnosed through a variety of tests including electrocardiograms (ECGs), stress tests, and holter monitors. Treatment options for cardiac arrhythmias vary depending on the type and severity of the condition and may include medications, cardioversion, catheter ablation, or implantable devices like pacemakers or defibrillators.

There are several possible causes of hypoventilation, including:

1. Respiratory muscle weakness or paralysis: This can be due to a variety of conditions, such as muscular dystrophy, amyotrophic lateral sclerosis (ALS), or spinal cord injury.
2. Chronic respiratory failure: This can be caused by conditions such as chronic obstructive pulmonary disease (COPD), interstitial lung disease, or pulmonary fibrosis.
3. Sleep apnea: Hypoventilation can occur during sleep due to the loss of muscle tone in the diaphragm and other respiratory muscles.
4. Anesthesia-induced hypoventilation: Some anesthetics can suppress the respiratory drive, leading to hypoventilation.
5. Drug overdose or intoxication: Certain drugs, such as opioids and benzodiazepines, can depress the central nervous system and lead to hypoventilation.
6. Trauma: Hypoventilation can occur in patients with severe injuries to the chest or abdomen that impair breathing.
7. Sepsis: Severe infections can cause hypoventilation by suppressing the respiratory drive.
8. Metabolic disorders: Certain metabolic disorders, such as diabetic ketoacidosis, can lead to hypoventilation.

Treatment of hypoventilation depends on the underlying cause and may include oxygen therapy, mechanical ventilation, and addressing any underlying conditions or complications. In some cases, hypoventilation may be a sign of a more severe condition that requires prompt medical attention to prevent further complications and improve outcomes.

The symptoms of Shy-Drager Syndrome can vary widely among individuals and may include:

* Cognitive decline
* Memory loss
* Difficulty with speech and language
* Loss of coordination and balance
* Dysphagia (difficulty swallowing)
* Weakness or paralysis of the limbs
* Bladder and bowel dysfunction
* Sleep disturbances

The exact cause of Shy-Drager Syndrome is not yet fully understood, but it is believed to be related to an autoimmune response, in which the body's immune system mistakenly attacks healthy cells in the brain. Genetic factors may also play a role in the development of the disorder.

There is no cure for Shy-Drager Syndrome, but various medications and therapies can help manage its symptoms. These may include:

* Cholinesterase inhibitors to improve cognitive function and slow the progression of dementia
* Anticholinergic drugs to reduce muscle rigidity and tremors
* Physical therapy to maintain mobility and strength
* Speech and language therapy to improve communication skills
* Occupational therapy to support daily living activities

The prognosis for Shy-Drager Syndrome is generally poor, with a median survival time of around 10-15 years after onset of symptoms. However, the rate of progression can vary widely among individuals, and some may experience a more gradual decline over several decades.

Overall, Shy-Drager Syndrome is a rare and complex disorder that requires careful management by a multidisciplinary team of healthcare professionals. While there is no cure for the condition, various therapies can help manage its symptoms and improve the quality of life for affected individuals.

* Heart block: A condition where the electrical signals that control the heart's rhythm are blocked or delayed, leading to a slow heart rate.
* Sinus node dysfunction: A condition where the sinus node, which is responsible for setting the heart's rhythm, is not functioning properly, leading to a slow heart rate.
* Medications: Certain medications, such as beta blockers, can slow down the heart rate.
* Heart failure: In severe cases of heart failure, the heart may become so weak that it cannot pump blood effectively, leading to a slow heart rate.
* Electrolyte imbalance: An imbalance of electrolytes, such as potassium or magnesium, can affect the heart's ability to function properly and cause a slow heart rate.
* Other medical conditions: Certain medical conditions, such as hypothyroidism (an underactive thyroid) or anemia, can cause bradycardia.

Bradycardia can cause symptoms such as:

* Fatigue
* Weakness
* Dizziness or lightheadedness
* Shortness of breath
* Chest pain or discomfort

In some cases, bradycardia may not cause any noticeable symptoms at all.

If you suspect you have bradycardia, it is important to consult with a healthcare professional for proper diagnosis and treatment. They may perform tests such as an electrocardiogram (ECG) or stress test to determine the cause of your slow heart rate and develop an appropriate treatment plan. Treatment options for bradycardia may include:

* Medications: Such as atropine or digoxin, to increase the heart rate.
* Pacemakers: A small device that is implanted in the chest to help regulate the heart's rhythm and increase the heart rate.
* Cardiac resynchronization therapy (CRT): A procedure that involves implanting a device that helps both ventricles of the heart beat together, improving the heart's pumping function.

It is important to note that bradycardia can be a symptom of an underlying condition, so it is important to address the underlying cause in order to effectively treat the bradycardia.

The most common types of CNS infections include:

1. Meningitis: Inflammation of the protective membranes (meninges) that cover the brain and spinal cord, often caused by bacteria or viruses.
2. Encephalitis: Inflammation of the brain tissue itself, usually caused by a virus.
3. Abscesses: Pockets of pus that form in the brain or spinal cord, typically caused by bacterial infections.
4. Cryptococcal infections: Caused by a fungus called Cryptococcus neoformans, often affecting people with weakened immune systems.
5. Toxoplasmosis: A parasitic infection caused by the Toxoplasma gondii parasite, which can affect the CNS in people with compromised immune systems.

Symptoms of CNS infections can vary depending on the specific type and severity of the infection, but may include fever, headache, confusion, seizures, weakness, and stiff neck. Diagnosis is typically made through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans.

Treatment of CNS infections depends on the underlying cause, but may involve antibiotics, antiviral medications, or antifungal drugs. In severe cases, hospitalization and supportive care such as intravenous fluids, oxygen therapy, and respiratory support may be necessary.

Prevention of CNS infections includes good hygiene practices such as frequent handwashing, avoiding close contact with people who are sick, and getting vaccinated against certain viruses that can cause CNS infections. Early diagnosis and prompt treatment are critical to preventing long-term complications of CNS infections and improving outcomes for patients.



Examples of Nervous System Diseases include:

1. Alzheimer's disease: A progressive neurological disorder that affects memory and cognitive function.
2. Parkinson's disease: A degenerative disorder that affects movement, balance and coordination.
3. Multiple sclerosis: An autoimmune disease that affects the protective covering of nerve fibers.
4. Stroke: A condition where blood flow to the brain is interrupted, leading to brain cell death.
5. Brain tumors: Abnormal growth of tissue in the brain.
6. Neuropathy: Damage to peripheral nerves that can cause pain, numbness and weakness in hands and feet.
7. Epilepsy: A disorder characterized by recurrent seizures.
8. Motor neuron disease: Diseases that affect the nerve cells responsible for controlling voluntary muscle movement.
9. Chronic pain syndrome: Persistent pain that lasts more than 3 months.
10. Neurodevelopmental disorders: Conditions such as autism, ADHD and learning disabilities that affect the development of the brain and nervous system.

These diseases can be caused by a variety of factors such as genetics, infections, injuries, toxins and ageing. Treatment options for Nervous System Diseases range from medications, surgery, rehabilitation therapy to lifestyle changes.

Some common types of nervous system neoplasms include:

1. Brain tumors: These are abnormal growths that develop in the brain, including gliomas (such as glioblastoma), meningiomas, and acoustic neuromas.
2. Spinal cord tumors: These are abnormal growths that develop in the spinal cord, including astrocytomas, oligodendrogliomas, and metastatic tumors.
3. Nerve sheath tumors: These are abnormal growths that develop in the covering of nerves, such as neurofibromas and schwannomas.
4. Pineal gland tumors: These are abnormal growths that develop in the pineal gland, a small endocrine gland located in the brain.

Symptoms of nervous system neoplasms can vary depending on their location and size, but may include headaches, seizures, weakness or numbness in the arms or legs, and changes in vision, speech, or balance. Diagnosis is typically made through a combination of imaging studies (such as MRI or CT scans) and tissue biopsy. Treatment options vary depending on the type and location of the tumor, but may include surgery, radiation therapy, and chemotherapy.

In summary, nervous system neoplasms are abnormal growths that can develop in the brain, spinal cord, and nerves, and can have a significant impact on the body. Diagnosis and treatment require a comprehensive approach, involving a team of medical professionals with expertise in neurology, neurosurgery, radiation oncology, and other related specialties.

There are several possible causes of orthostatic hypotension, including:

1. Deconditioning: This is a common cause of orthostatic hypotension in older adults who have been bedridden or hospitalized for prolonged periods.
2. Medication side effects: Certain medications, such as beta blockers and vasodilators, can cause orthostatic hypotension as a side effect.
3. Heart conditions: Conditions such as heart failure, arrhythmias, and structural heart defects can lead to orthostatic hypotension.
4. Neurological disorders: Certain neurological disorders, such as Parkinson's disease, multiple sclerosis, and stroke, can cause orthostatic hypotension.
5. Vasomotor instability: This is a condition where the blood vessels constrict or dilate rapidly, leading to a drop in blood pressure.
6. Anemia: A low red blood cell count can lead to a decrease in oxygen delivery to the body's tissues, causing orthostatic hypotension.
7. Dehydration: Dehydration can cause a drop in blood volume and lead to orthostatic hypotension.
8. Hypovolemia: This is a condition where there is a low volume of blood in the body, leading to a drop in blood pressure.
9. Sepsis: Sepsis can cause vasodilation and lead to orthostatic hypotension.
10. Other causes: Other causes of orthostatic hypotension include adrenal insufficiency, thyroid disorders, and certain genetic conditions.

Symptoms of orthostatic hypotension may include:

* Dizziness or lightheadedness
* Fainting
* Blurred vision
* Nausea and vomiting
* Headaches
* Fatigue
* Weakness
* Confusion

If you experience any of these symptoms, it is important to seek medical attention as soon as possible. Your healthcare provider can perform a physical examination and order diagnostic tests to determine the underlying cause of your orthostatic hypotension. Treatment will depend on the specific cause, but may include medications to raise blood pressure, fluid replacement, and addressing any underlying conditions.

Examples of abnormal reflexes include:

1. Overactive reflexes: Reflexes that are too strong or exaggerated, such as an oversensitive knee jerk reflex.
2. Underactive reflexes: Reflexes that are too weak or diminished, such as a decreased tendon reflex in the arm.
3. Delayed reflexes: Reflexes that take longer than expected to occur, such as a delayed deep tendon reflex.
4. Abnormal reflex arc: A reflex arc that is not normal or expected for the situation, such as a spastic reflex arc.
5. Reflexes that are out of proportion to the stimulus: Such as an excessive or exaggerated reflex response to a mild stimulus.
6. Reflexes that occur in the absence of a stimulus: Such as a spontaneous reflex.
7. Reflexes that do not resolve: Such as a persistent reflex.
8. Reflexes that are painful or uncomfortable: Such as an abnormal rectal reflex.

It's important to note that not all abnormal reflexes are necessarily indicative of a serious medical condition, but they should be evaluated by a healthcare professional to determine the underlying cause and appropriate treatment.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

There are two types of hypertension:

1. Primary Hypertension: This type of hypertension has no identifiable cause and is also known as essential hypertension. It accounts for about 90% of all cases of hypertension.
2. Secondary Hypertension: This type of hypertension is caused by an underlying medical condition or medication. It accounts for about 10% of all cases of hypertension.

Some common causes of secondary hypertension include:

* Kidney disease
* Adrenal gland disorders
* Hormonal imbalances
* Certain medications
* Sleep apnea
* Cocaine use

There are also several risk factors for hypertension, including:

* Age (the risk increases with age)
* Family history of hypertension
* Obesity
* Lack of exercise
* High sodium intake
* Low potassium intake
* Stress

Hypertension is often asymptomatic, and it can cause damage to the blood vessels and organs over time. Some potential complications of hypertension include:

* Heart disease (e.g., heart attacks, heart failure)
* Stroke
* Kidney disease (e.g., chronic kidney disease, end-stage renal disease)
* Vision loss (e.g., retinopathy)
* Peripheral artery disease

Hypertension is typically diagnosed through blood pressure readings taken over a period of time. Treatment for hypertension may include lifestyle changes (e.g., diet, exercise, stress management), medications, or a combination of both. The goal of treatment is to reduce the risk of complications and improve quality of life.

Some common examples of CNSVD include:

1. Herpes simplex virus (HSV) encephalitis: This is an inflammation of the brain caused by the herpes simplex virus. It can cause fever, headache, confusion, and seizures.
2. West Nile virus (WNV) encephalitis: This is an infection of the brain caused by the West Nile virus, which is transmitted through the bite of an infected mosquito. Symptoms can include fever, headache, muscle weakness, and confusion.
3. Japanese encephalitis (JE): This is a viral infection that affects the brain and is transmitted through the bite of an infected mosquito. Symptoms can include fever, headache, seizures, and changes in behavior or cognitive function.
4. Rabies: This is a viral infection that affects the brain and is transmitted through the bite of an infected animal, usually a dog, bat, or raccoon. Symptoms can include fever, headache, agitation, and changes in behavior or cognitive function.
5. Enteroviral encephalitis: This is an infection of the brain caused by enteroviruses, which are common viruses that affect the gastrointestinal tract. Symptoms can include fever, vomiting, diarrhea, and changes in behavior or cognitive function.

The diagnosis of CNSVD typically involves a combination of physical examination, laboratory tests (such as blood tests or lumbar puncture), and imaging studies (such as CT or MRI scans). Treatment options vary depending on the specific disease and may include antiviral medications, supportive care, and rehabilitation.

Prevention of CNSVD includes avoiding exposure to mosquitoes and other vectors that can transmit disease, maintaining good hygiene practices (such as washing hands frequently), and getting vaccinated against diseases such as rabies and measles. In addition, taking steps to prevent head trauma and using protective equipment when engaging in activities that involve risk of head injury can help reduce the risk of CNSVD.

Overall, while central nervous system viral diseases can be serious and potentially life-threatening, early diagnosis and treatment can improve outcomes and prevent long-term complications. It is important to seek medical attention promptly if symptoms persist or worsen over time.

Paragangliomas are rare, accounting for less than 1% of all tumors diagnosed in adults. They can occur at any age but are more common in young adults and middle-aged individuals. These tumors are more common in males than females, and their incidence is higher in certain families with inherited syndromes, such as neurofibromatosis type 1 (NF1) or familial paraganglioma.

The symptoms of paraganglioma depend on their location and size. Small tumors may not cause any symptoms, while larger tumors can press on nearby organs and structures, causing a variety of symptoms such as:

* Pain in the abdomen or pelvis
* Swelling or lump in the neck or abdomen
* High blood pressure
* Headaches
* Blurred vision
* Confusion or seizures (in cases of malignant paraganglioma)

Paragangliomas are difficult to diagnose, as they can be mistaken for other conditions such as appendicitis or pancreatitis. Imaging studies such as CT or MRI scans are often used to help identify the location and size of the tumor, while laboratory tests may be used to evaluate hormone levels and other factors that can help differentiate paraganglioma from other conditions.

Treatment for paraganglioma depends on the type, size, and location of the tumor, as well as the patient's overall health status. Small, benign tumors may not require treatment, while larger or malignant tumors may be treated with surgery, chemotherapy, or radiation therapy. In some cases, a combination of these treatments may be used.

The prognosis for paraganglioma is generally good if the tumor is diagnosed and treated early, but it can be poor if the tumor is large or has spread to other parts of the body. With surgical removal of the tumor, the 5-year survival rate is approximately 90% for patients with benign paraganglioma and 30-50% for those with malignant paraganglioma. However, the overall prognosis can vary depending on individual factors such as the size and location of the tumor, the effectiveness of treatment, and the patient's underlying health status.

There are several types of diabetic neuropathies, including:

1. Peripheral neuropathy: This is the most common type of diabetic neuropathy and affects the nerves in the hands and feet. It can cause numbness, tingling, and pain in these areas.
2. Autonomic neuropathy: This type of neuropathy affects the nerves that control involuntary functions, such as digestion, bladder function, and blood pressure. It can cause a range of symptoms, including constipation, diarrhea, urinary incontinence, and sexual dysfunction.
3. Proximal neuropathy: This type of neuropathy affects the nerves in the legs and hips. It can cause weakness, pain, and stiffness in these areas.
4. Focal neuropathy: This type of neuropathy affects a single nerve, often causing sudden and severe pain.

The exact cause of diabetic neuropathies is not fully understood, but it is thought to be related to high blood sugar levels over time. Other risk factors include poor blood sugar control, obesity, smoking, and alcohol consumption. There is no cure for diabetic neuropathy, but there are several treatments available to manage the symptoms and prevent further nerve damage. These treatments may include medications, physical therapy, and lifestyle changes such as regular exercise and a healthy diet.

In extreme cases, hypoglycemia can lead to seizures, loss of consciousness, and even coma. It is important to recognize the symptoms of hypoglycemia early on and seek medical attention if they persist or worsen over time. Treatment typically involves raising blood sugar levels through the consumption of quick-acting carbohydrates such as glucose tablets, fruit juice, or hard candy.

If left untreated, hypoglycemia can have serious consequences, including long-term damage to the brain, heart, and other organs. It is important for individuals with diabetes to monitor their blood sugar levels regularly and work with their healthcare provider to manage their condition effectively.

www.medicinenet.com/sudden_death/article.htm
Sudden death is death that occurs unexpectedly and without warning, often due to a cardiac arrest or other underlying medical condition.

In the medical field, sudden death is defined as death that occurs within one hour of the onset of symptoms, with no prior knowledge of any serious medical condition. It is often caused by a cardiac arrhythmia, such as ventricular fibrillation or tachycardia, which can lead to cardiac arrest and sudden death if not treated promptly.

Other possible causes of sudden death include:

1. Heart disease: Coronary artery disease, heart failure, and other heart conditions can increase the risk of sudden death.
2. Stroke: A stroke can cause sudden death by disrupting blood flow to the brain or other vital organs.
3. Pulmonary embolism: A blood clot in the lungs can block blood flow and cause sudden death.
4. Trauma: Sudden death can occur as a result of injuries sustained in an accident or other traumatic event.
5. Drug overdose: Taking too much of certain medications or drugs can cause sudden death due to cardiac arrest or respiratory failure.
6. Infections: Sepsis, meningitis, and other severe infections can lead to sudden death if left untreated.
7. Genetic conditions: Certain inherited disorders, such as Long QT syndrome, can increase the risk of sudden death due to cardiac arrhythmias.

The diagnosis of sudden death often requires an autopsy and a thorough investigation into the individual's medical history and circumstances surrounding their death. Treatment and prevention strategies may include defibrillation, CPR, medications to regulate heart rhythm, and lifestyle modifications to reduce risk factors such as obesity, smoking, and high blood pressure.

The exact cause of CNS vasculitis is not fully understood, but it is believed to be an autoimmune disorder, meaning that the immune system mistakenly attacks healthy tissues in the CNS. The condition can occur at any age, but it most commonly affects adults between the ages of 40 and 60.

Symptoms of CNS vasculitis can vary depending on the location and severity of the inflammation, but may include:

* Headaches
* Confusion
* Memory loss
* Seizures
* Weakness or numbness in the limbs
* Vision problems
* Speech difficulties

Diagnosis of CNS vasculitis typically involves a combination of physical examination, medical history, and diagnostic tests such as MRI or CT scans, lumbar puncture, and blood tests. Treatment options for CNS vasculitis vary depending on the severity of the condition and may include corticosteroids, immunosuppressive drugs, and plasmapheresis. In severe cases, surgery may be necessary to relieve pressure on the brain or spinal cord.

Overall, CNS vasculitis is a serious condition that can have significant neurological consequences if left untreated. Early diagnosis and aggressive treatment are critical to prevent long-term damage and improve outcomes for patients with this condition.

Examples of syndromes include:

1. Down syndrome: A genetic disorder caused by an extra copy of chromosome 21 that affects intellectual and physical development.
2. Turner syndrome: A genetic disorder caused by a missing or partially deleted X chromosome that affects physical growth and development in females.
3. Marfan syndrome: A genetic disorder affecting the body's connective tissue, causing tall stature, long limbs, and cardiovascular problems.
4. Alzheimer's disease: A neurodegenerative disorder characterized by memory loss, confusion, and changes in personality and behavior.
5. Parkinson's disease: A neurological disorder characterized by tremors, rigidity, and difficulty with movement.
6. Klinefelter syndrome: A genetic disorder caused by an extra X chromosome in males, leading to infertility and other physical characteristics.
7. Williams syndrome: A rare genetic disorder caused by a deletion of genetic material on chromosome 7, characterized by cardiovascular problems, developmental delays, and a distinctive facial appearance.
8. Fragile X syndrome: The most common form of inherited intellectual disability, caused by an expansion of a specific gene on the X chromosome.
9. Prader-Willi syndrome: A genetic disorder caused by a defect in the hypothalamus, leading to problems with appetite regulation and obesity.
10. Sjogren's syndrome: An autoimmune disorder that affects the glands that produce tears and saliva, causing dry eyes and mouth.

Syndromes can be diagnosed through a combination of physical examination, medical history, laboratory tests, and imaging studies. Treatment for a syndrome depends on the underlying cause and the specific symptoms and signs presented by the patient.

There are several types of tachycardia, including:

1. Sinus tachycardia: This is the most common type and is caused by an increase in the rate of the normal sinus node. It is often seen in response to physical activity or stress.
2. Atrial fibrillation: This is a type of arrhythmia where the heart's upper chambers (atria) contract irregularly and rapidly, leading to a rapid heart rate.
3. Ventricular tachycardia: This is a type of arrhythmia where the heart's lower chambers (ventricles) contract rapidly, often with a rate above 100 bpm.
4. Premature ventricular contractions (PVCs): These are early or extra beats that originate in the ventricles, causing a rapid heart rate.

Tachycardia can cause a range of symptoms, including palpitations, shortness of breath, chest pain, and dizziness. In severe cases, it can lead to cardiac arrhythmias, heart failure, and even death.

Diagnosis of tachycardia typically involves a physical examination, electrocardiogram (ECG), and other tests such as stress tests or echocardiography. Treatment options vary depending on the underlying cause, but may include medications to regulate the heart rate, cardioversion to restore a normal heart rhythm, or in severe cases, implantation of a pacemaker or defibrillator.

Some examples of the use of 'Death, Sudden, Cardiac' in medical contexts include:

1. Sudden cardiac death (SCD) is a major public health concern, affecting thousands of people each year in the United States alone. It is often caused by inherited heart conditions, such as hypertrophic cardiomyopathy or long QT syndrome.
2. The risk of sudden cardiac death is higher for individuals with a family history of heart disease or other pre-existing cardiovascular conditions.
3. Sudden cardiac death can be prevented by prompt recognition and treatment of underlying heart conditions, as well as by avoiding certain risk factors such as smoking, physical inactivity, and an unhealthy diet.
4. Cardiopulmonary resuscitation (CPR) and automated external defibrillators (AEDs) can be effective in restoring a normal heart rhythm during sudden cardiac death, especially when used promptly after the onset of symptoms.

There are several causes of hypotension, including:

1. Dehydration: Loss of fluids and electrolytes can cause a drop in blood pressure.
2. Blood loss: Losing too much blood can lead to hypotension.
3. Medications: Certain medications, such as diuretics and beta-blockers, can lower blood pressure.
4. Heart conditions: Heart failure, cardiac tamponade, and arrhythmias can all cause hypotension.
5. Endocrine disorders: Hypothyroidism (underactive thyroid) and adrenal insufficiency can cause low blood pressure.
6. Vasodilation: A condition where the blood vessels are dilated, leading to low blood pressure.
7. Sepsis: Severe infection can cause hypotension.

Symptoms of hypotension can include:

1. Dizziness and lightheadedness
2. Fainting or passing out
3. Weakness and fatigue
4. Confusion and disorientation
5. Pale, cool, or clammy skin
6. Fast or weak pulse
7. Shortness of breath
8. Nausea and vomiting

If you suspect that you or someone else is experiencing hypotension, it is important to seek medical attention immediately. Treatment will depend on the underlying cause of the condition, but may include fluids, electrolytes, and medication to raise blood pressure. In severe cases, hospitalization may be necessary.

The exact cause of vasovagal syncope is not fully understood, but it is thought to be related to an imbalance in the autonomic nervous system (which controls involuntary functions such as heart rate and blood pressure). It can be triggered by a variety of factors, including:

* Strong emotions such as fear or anxiety
* Pain or discomfort
* Intense physical activity
* Dehydration or low blood sugar
* Certain medications

During a vasovagal syncope episode, the person may experience symptoms such as:

* Dizziness or lightheadedness
* Blurred vision
* Nausea or vomiting
* Sweating
* Feeling of impending doom or loss of control
* Eventually, fainting or falling to the ground

Diagnosis of vasovagal syncope is typically made based on a combination of symptoms and physical examination findings. Tests such as an electrocardiogram (ECG) or blood tests may be ordered to rule out other conditions that may be causing the symptoms. Treatment for vasovagal syncope usually involves addressing any underlying triggers, such as managing stress or avoiding certain stimuli that may cause the episodes. In some cases, medications such as beta blockers or antidepressants may be prescribed to help regulate the heart rate and blood pressure.

There are several risk factors for developing AF, including:

1. Age: The risk of developing AF increases with age, with the majority of cases occurring in people over the age of 65.
2. Hypertension (high blood pressure): High blood pressure can damage the heart and increase the risk of developing AF.
3. Heart disease: People with heart disease, such as coronary artery disease or heart failure, are at higher risk of developing AF.
4. Diabetes mellitus: Diabetes can increase the risk of developing AF.
5. Sleep apnea: Sleep apnea can increase the risk of developing AF.
6. Certain medications: Certain medications, such as thyroid medications and asthma medications, can increase the risk of developing AF.
7. Alcohol consumption: Excessive alcohol consumption has been linked to an increased risk of developing AF.
8. Smoking: Smoking is a risk factor for many cardiovascular conditions, including AF.
9. Obesity: Obesity is a risk factor for many cardiovascular conditions, including AF.

Symptoms of AF can include:

1. Palpitations (rapid or irregular heartbeat)
2. Shortness of breath
3. Fatigue
4. Dizziness or lightheadedness
5. Chest pain or discomfort

AF can be diagnosed with the help of several tests, including:

1. Electrocardiogram (ECG): This is a non-invasive test that measures the electrical activity of the heart.
2. Holter monitor: This is a portable device that records the heart's rhythm over a 24-hour period.
3. Event monitor: This is a portable device that records the heart's rhythm over a longer period of time, usually 1-2 weeks.
4. Echocardiogram: This is an imaging test that uses sound waves to create pictures of the heart.
5. Cardiac MRI: This is an imaging test that uses magnetic fields and radio waves to create detailed pictures of the heart.

Treatment for AF depends on the underlying cause and may include medications, such as:

1. Beta blockers: These medications slow the heart rate and reduce the force of the heart's contractions.
2. Antiarrhythmics: These medications help regulate the heart's rhythm.
3. Blood thinners: These medications prevent blood clots from forming and can help reduce the risk of stroke.
4. Calcium channel blockers: These medications slow the entry of calcium into the heart muscle cells, which can help slow the heart rate and reduce the force of the heart's contractions.

In some cases, catheter ablation may be recommended to destroy the abnormal electrical pathway causing AF. This is a minimally invasive procedure that involves inserting a catheter through a vein in the leg and guiding it to the heart using x-ray imaging. Once the catheter is in place, energy is applied to the abnormal electrical pathway to destroy it and restore a normal heart rhythm.

It's important to note that AF can increase the risk of stroke, so anticoagulation therapy may be recommended to reduce this risk. This can include medications such as warfarin or aspirin, or in some cases, implantable devices such as a left atrial appendage closure device.

In conclusion, atrial fibrillation is a common heart rhythm disorder that can increase the risk of stroke and heart failure. Treatment options depend on the underlying cause and may include medications, cardioversion, catheter ablation, or anticoagulation therapy. It's important to work closely with a healthcare provider to determine the best course of treatment for AF.

There are several subtypes of IBS, including:

* IBS-C (constipation-predominant)
* IBS-D (diarrhea-predominant)
* IBS-M (mixed)

The symptoms of IBS can vary in severity and frequency from person to person, and may include:

* Abdominal pain or cramping
* Bloating
* Gas
* Diarrhea or constipation
* Mucus in the stool
* Feeling of incomplete evacuation after bowel movements

There is no cure for IBS, but symptoms can be managed with dietary changes, stress management techniques, and medications such as fiber supplements, antispasmodics, and antidepressants. It is important to seek medical advice if symptoms persist or worsen over time, as IBS can have a significant impact on quality of life and may be associated with other conditions such as anxiety or depression.

Trauma to the nervous system can have a profound impact on an individual's quality of life, and can lead to a range of symptoms including:

* Headaches
* Dizziness and vertigo
* Memory loss and difficulty concentrating
* Mood changes such as anxiety, depression, or irritability
* Sleep disturbances
* Changes in sensation, such as numbness or tingling
* Weakness or paralysis of certain muscle groups

Trauma to the nervous system can also have long-lasting effects, and may lead to chronic conditions such as post-traumatic stress disorder (PTSD), chronic pain, and fibromyalgia.

Treatment for trauma to the nervous system will depend on the specific nature of the injury and the severity of the symptoms. Some common treatments include:

* Medication to manage symptoms such as pain, anxiety, or depression
* Physical therapy to help regain strength and mobility
* Occupational therapy to help with daily activities and improve function
* Cognitive-behavioral therapy (CBT) to address any emotional or psychological issues
* Alternative therapies such as acupuncture, massage, or meditation to help manage symptoms and promote relaxation.

It's important to seek medical attention if you experience any symptoms of trauma to the nervous system, as prompt treatment can help reduce the risk of long-term complications and improve outcomes.

The most common types of CNS fungal infections include:

1. Meningitis: An inflammation of the membranes that cover the brain and spinal cord, caused by fungi such as Candida, Aspergillus, or Cryptococcus.
2. Encephalitis: An inflammation of the brain tissue itself, caused by fungi such as Histoplasma or Coccidioides.
3. Abscesses: Pocket of pus that form in the brain or spinal cord, caused by bacteria or fungi.
4. Opportunistic infections: Infections that occur in people with compromised immune systems, such as HIV/AIDS patients or those taking immunosuppressive drugs after an organ transplant.

CNS fungal infections can cause a wide range of symptoms, including headache, fever, confusion, seizures, and loss of coordination. They are typically diagnosed through a combination of physical examination, laboratory tests, and imaging studies such as CT or MRI scans.

Treatment of CNS fungal infections usually involves the use of antifungal medications, which can be administered intravenously or orally. The choice of treatment depends on the severity and location of the infection, as well as the patient's overall health status. In some cases, surgery may be necessary to drain abscesses or relieve pressure on the brain.

Prevention of CNS fungal infections is important for individuals at risk, such as those with compromised immune systems or underlying medical conditions. This includes taking antifungal medications prophylactically, avoiding exposure to fungal spores, and practicing good hygiene.

Overall, CNS fungal infections are serious and potentially life-threatening conditions that require prompt diagnosis and treatment. With appropriate management, many patients can recover fully, but delays in diagnosis and treatment can lead to poor outcomes.

Myocardial ischemia can be caused by a variety of factors, including coronary artery disease, high blood pressure, diabetes, and smoking. It can also be triggered by physical exertion or stress.

There are several types of myocardial ischemia, including:

1. Stable angina: This is the most common type of myocardial ischemia, and it is characterized by a predictable pattern of chest pain that occurs during physical activity or emotional stress.
2. Unstable angina: This is a more severe type of myocardial ischemia that can occur without any identifiable trigger, and can be accompanied by other symptoms such as shortness of breath or vomiting.
3. Acute coronary syndrome (ACS): This is a condition that includes both stable angina and unstable angina, and it is characterized by a sudden reduction in blood flow to the heart muscle.
4. Heart attack (myocardial infarction): This is a type of myocardial ischemia that occurs when the blood flow to the heart muscle is completely blocked, resulting in damage or death of the cardiac tissue.

Myocardial ischemia can be diagnosed through a variety of tests, including electrocardiograms (ECGs), stress tests, and imaging studies such as echocardiography or cardiac magnetic resonance imaging (MRI). Treatment options for myocardial ischemia include medications such as nitrates, beta blockers, and calcium channel blockers, as well as lifestyle changes such as quitting smoking, losing weight, and exercising regularly. In severe cases, surgical procedures such as coronary artery bypass grafting or angioplasty may be necessary.

There are several different types of pain, including:

1. Acute pain: This type of pain is sudden and severe, and it usually lasts for a short period of time. It can be caused by injuries, surgery, or other forms of tissue damage.
2. Chronic pain: This type of pain persists over a long period of time, often lasting more than 3 months. It can be caused by conditions such as arthritis, fibromyalgia, or nerve damage.
3. Neuropathic pain: This type of pain results from damage to the nervous system, and it can be characterized by burning, shooting, or stabbing sensations.
4. Visceral pain: This type of pain originates in the internal organs, and it can be difficult to localize.
5. Psychogenic pain: This type of pain is caused by psychological factors such as stress, anxiety, or depression.

The medical field uses a range of methods to assess and manage pain, including:

1. Pain rating scales: These are numerical scales that patients use to rate the intensity of their pain.
2. Pain diaries: These are records that patients keep to track their pain over time.
3. Clinical interviews: Healthcare providers use these to gather information about the patient's pain experience and other relevant symptoms.
4. Physical examination: This can help healthcare providers identify any underlying causes of pain, such as injuries or inflammation.
5. Imaging studies: These can be used to visualize the body and identify any structural abnormalities that may be contributing to the patient's pain.
6. Medications: There are a wide range of medications available to treat pain, including analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), and muscle relaxants.
7. Alternative therapies: These can include acupuncture, massage, and physical therapy.
8. Interventional procedures: These are minimally invasive procedures that can be used to treat pain, such as nerve blocks and spinal cord stimulation.

It is important for healthcare providers to approach pain management with a multi-modal approach, using a combination of these methods to address the physical, emotional, and social aspects of pain. By doing so, they can help improve the patient's quality of life and reduce their suffering.

CNS bacterial infections can cause a wide range of symptoms, including fever, headache, confusion, seizures, and loss of consciousness. In severe cases, these infections can lead to meningitis, encephalitis, or abscesses in the brain or spinal cord.

The diagnosis of CNS bacterial infections is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include blood cultures, cerebrospinal fluid (CSF) cultures, and polymerase chain reaction (PCR) tests to identify the causative bacteria. Imaging studies, such as computed tomography (CT) or magnetic resonance imaging (MRI), may be used to visualize the extent of the infection.

Treatment of CNS bacterial infections typically involves the use of antibiotics, which can help to clear the infection and prevent further complications. In some cases, surgical intervention may be necessary to drain abscesses or relieve pressure on the brain or spinal cord.

Preventive measures for CNS bacterial infections include vaccination against certain types of bacteria, such as Streptococcus pneumoniae and Haemophilus influenzae, good hygiene practices, and appropriate use of antibiotics. Early diagnosis and treatment are critical to preventing long-term neurological damage or death.

In conclusion, CNS bacterial infections can be serious and potentially life-threatening conditions that require prompt diagnosis and treatment. Understanding the causes, symptoms, diagnosis, treatment, and prevention of these infections is essential for effective management and optimal outcomes for patients affected by them.

There are several key features of inflammation:

1. Increased blood flow: Blood vessels in the affected area dilate, allowing more blood to flow into the tissue and bringing with it immune cells, nutrients, and other signaling molecules.
2. Leukocyte migration: White blood cells, such as neutrophils and monocytes, migrate towards the site of inflammation in response to chemical signals.
3. Release of mediators: Inflammatory mediators, such as cytokines and chemokines, are released by immune cells and other cells in the affected tissue. These molecules help to coordinate the immune response and attract more immune cells to the site of inflammation.
4. Activation of immune cells: Immune cells, such as macrophages and T cells, become activated and start to phagocytose (engulf) pathogens or damaged tissue.
5. Increased heat production: Inflammation can cause an increase in metabolic activity in the affected tissue, leading to increased heat production.
6. Redness and swelling: Increased blood flow and leakiness of blood vessels can cause redness and swelling in the affected area.
7. Pain: Inflammation can cause pain through the activation of nociceptors (pain-sensing neurons) and the release of pro-inflammatory mediators.

Inflammation can be acute or chronic. Acute inflammation is a short-term response to injury or infection, which helps to resolve the issue quickly. Chronic inflammation is a long-term response that can cause ongoing damage and diseases such as arthritis, asthma, and cancer.

There are several types of inflammation, including:

1. Acute inflammation: A short-term response to injury or infection.
2. Chronic inflammation: A long-term response that can cause ongoing damage and diseases.
3. Autoimmune inflammation: An inappropriate immune response against the body's own tissues.
4. Allergic inflammation: An immune response to a harmless substance, such as pollen or dust mites.
5. Parasitic inflammation: An immune response to parasites, such as worms or fungi.
6. Bacterial inflammation: An immune response to bacteria.
7. Viral inflammation: An immune response to viruses.
8. Fungal inflammation: An immune response to fungi.

There are several ways to reduce inflammation, including:

1. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying anti-rheumatic drugs (DMARDs).
2. Lifestyle changes, such as a healthy diet, regular exercise, stress management, and getting enough sleep.
3. Alternative therapies, such as acupuncture, herbal supplements, and mind-body practices.
4. Addressing underlying conditions, such as hormonal imbalances, gut health issues, and chronic infections.
5. Using anti-inflammatory compounds found in certain foods, such as omega-3 fatty acids, turmeric, and ginger.

It's important to note that chronic inflammation can lead to a range of health problems, including:

1. Arthritis
2. Diabetes
3. Heart disease
4. Cancer
5. Alzheimer's disease
6. Parkinson's disease
7. Autoimmune disorders, such as lupus and rheumatoid arthritis.

Therefore, it's important to manage inflammation effectively to prevent these complications and improve overall health and well-being.

The autonomic nervous system is divided into the sympathetic nervous system and parasympathetic nervous system. The sympathetic ... the autonomic nervous system has four branches: the sympathetic nervous system, the parasympathetic nervous system, the ... "autonomic nervous system" at Dorland's Medical Dictionary Schmidt, A; Thews, G (1989). "Autonomic Nervous System". In Janig, W ... The autonomic nervous system (ANS), formerly referred to as the vegetative nervous system, is a division of the peripheral ...
... mainly affects the endocrine system and autonomic nervous system, but patients can exhibit a variety of signs. Patients ... Autonomic dysfunction refers to the autonomic nervous system, which is responsible for regulating internal processes without ... autonomic nervous system, and endocrine system. Symptoms related to hypothalamic dysfunction may include abnormal sodium ... "autonomic nervous system , Divisions & Functions". Encyclopedia Britannica. Retrieved 2018-06-06. Pontual, Loic De; Trochet, ...
Such bundles are able to send an action potential from the autonomic nervous system to the rest of the body. However, action ... "Autonomic Nervous System". PubMed Health. Lance, J. W. (2005). "Harlequin syndrome". Practical Neurology. 5 (3): 176-177. doi: ... Harlequin syndrome is considered an injury to the autonomic nervous system (ANS). The ANS controls some of the body's natural ... Since Harlequin syndrome is associated with a dysfunction in the autonomic nervous system, main symptoms of this dysfunction ...
... ". Handbook of Clinical Neurology. Autonomic Nervous System. Elsevier. 117: 243-257. doi:10.1016/b978-0- ... A degenerative disease of the autonomic nervous system, symptoms include dizziness and fainting (caused by orthostatic ... indicate possible autoimmune autonomic ganglionopathy or multiple system atrophy. The pathology of pure autonomic failure is ... It is relevant to note that progression to central nervous system neurodegeneration can also occur. It is also known as ...
The autonomic nervous system is a control system that acts largely unconsciously and regulates heart rate, digestion, ... the sympathetic nervous system and the parasympathetic nervous system. The sympathetic nervous system originates in the spinal ... Schmidt, A; Thews, G (1989). "Autonomic Nervous System". In Janig, W (ed.). Human Physiology (2 ed.). New York, NY: Springer- ... This component of the autonomic nervous system utilises and activates the release of norepinephrine in the reaction. The ...
The Autonomic Nervous System. Cambridge : W. Heffer & Sons, Ltd. 1921. p. 6. Johnson, Joel O. (2013), "Autonomic Nervous System ... "autonomic nervous system" (ANS) in 1898. He was the first person who put forward the concept of parasympathetic nervous system ... The Autonomic Nervous System (1921) Elementary Experimental Physiology A brass plaque to Langley's memory exists in Trinity ... who made substantive discoveries about the nervous system and secretion. He was born in Newbury, Berkshire the son of John ...
"Peripheral Autonomic Nervous System". In Robertson D, Biaggioni I, et al. (eds.). Primer on the Autonomic Nervous System. ... Kenney MJ, Ganta CK (July 2014). "Autonomic nervous system and immune system interactions". Comprehensive Physiology. 4 (3): ... Bahler L, Molenaars RJ, Verberne HJ, Holleman F (September 2015). "Role of the autonomic nervous system in activation of human ... The sympathetic nervous system is the primary path of interaction between the immune system and the brain, and several ...
The autonomic nervous system. Edited by C. L. Bolis and J. Licinio. World Health Organization. hdl:10665/66029. {{cite book ... Who Meeting on Stress and the Nervous System (1998: Athens, Greece) (1998). Stress and the nervous system. Edited by C. L. ... central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, ... and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: pathophysiological ...
... when it was learned that the autonomic nervous system runs to almost every organ, gland and muscle system in the body. It was ... "The neurochemical organization of the autonomic nervous system". In Appenzeller O, Vinken PJ, Bruyn GW (eds.). The autonomic ... The autonomic nervous system is not anatomically exact and connections might exist which are unpredictably affected when the ... Sympathectomy works by disabling part of the autonomic nervous system (and thereby disrupting its signals from the brain), ...
"The Autonomic Nervous System". Archived from the original on 11 June 2008. Retrieved 12 June 2008. Streeten, DVH. "The ... the activity of the parasympathetic nervous system increases and the activity of the sympathetic nervous system decreases. This ... The larger the meal, the greater the shift in autonomic tone towards the parasympathetic system, regardless of the composition ... a general state of low energy related to activation of the parasympathetic nervous system in response to mass in the ...
Autonomic Nervous System". StatPearls Publishing. PMID 30969667 - via Europe PMC. Bapna, Anisha; Adin, Christopher; Engelman, ...
The collected information gives specialists important insight into the autonomic nervous system and the cardiovascular system. ... Sleep and Breathing 2019 Aug: 1-12.. [7]> (Autonomic nervous system, Cardiovascular system). ... Such arousals elicit generalized autonomic activation, which among other physiological changes, includes sympathetic nervous ... variable pressure pneumatic system, which also supplies the desired level of pressure to be used. The PAT Technology has ...
Burn worked on the internal control of the body by the autonomic nervous system, carrying out seminal work on the release of ... The Autonomic Nervous System, 1963; Our most interesting Diseases, 1964; A Defence of John Balliol, 1970 Bulbring, E.; Walker, ... Functions of Autonomic Transmitters, 1956; The Principles of Therapeutics, 1957; Drugs, Medicines and Man, 1962; ...
... function refers to the autonomic nervous system control of sweat gland activity in response to various environmental ... Impaired sudomotor function can occur in any disorder that directly and/or indirectly affects the autonomic nervous system, ... Freeman, Roy; Chapleau, Mark W. (2013). "Testing the autonomic nervous system". Peripheral Nerve Disorders. Handbook of ... "A Simple and Accurate Method to Assess Autonomic Nervous System through Sudomotor Function". In Yurish, Sergey (ed.). Advances ...
the autonomic nervous system (ANS). The ANS is divided into subsystems: the sympathetic nervous system (SNS) and the ... The nervous system is composed of a central nervous system (CNS), brain and spinal cord, and the peripheral nervous system (PNS ... The central nervous system provides control and coordination of all eleven body systems and utilizes the endocrine system to ... The endocrine system is under the direct supervision of the nervous system, using the negative feedback principal of ...
... carrying fibers of the autonomic nervous system (visceral efferent fibers) as well as sensory fibers from the organs (visceral ... Page 181 (Autonomic nervous system). ...
Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 9: Autonomic Nervous System". In Sydor A, Brown RY (eds.). Molecular ... Yoshida T, Sakane N, Umekawa T, Kondo M (January 1994). "Effect of nicotine on sympathetic nervous system activity of mice ... Nicotine also activates the sympathetic nervous system, acting via splanchnic nerves to the adrenal medulla, stimulating the ... Immune cells of both the Innate immune system and adaptive immune systems frequently express the α2, α5, α6, α7, α9, and α10 ...
ISBN 978-0-07-020291-7. Raffe RB (2004). Autonomic and Somatic Nervous Systems in Netter's Illustrated Pharmacology. Elsevier ... Primer on the Autonomic Nervous System. Elsevier. pp. 631-633. doi:10.1016/b978-0-12-386525-0.00132-3. ISBN 978-0-12-386525-0 ... leading to increased cholinergic signaling within the central nervous system, autonomic ganglia and neuromuscular junctions. ... In the central nervous system it is associated with PRiMA which stands for Proline Rich Membrane anchor to form symmetric form ...
The polyvagal theory is another way to describe the pathways in the autonomic nervous system that mediate HRV. The polyvagal ... HRV is reported to be an index of the influence of both the parasympathetic nervous system and the sympathetic nervous systems ... Mizuno T, Tamakoshi K, Tanabe K (August 2017). "Anxiety during pregnancy and autonomic nervous system activity: A longitudinal ... Journal of the Autonomic Nervous System. 57 (1-2): 123-127. doi:10.1016/0165-1838(95)00104-2. PMID 8867095. Billman GE (2013 ...
Burnstock, Geoffrey (2012). "Cotransmission". Primer on the Autonomic Nervous System. pp. 27-33. doi:10.1016/B978-0-12-386525- ... The nervous system stood as an exception. Although nerve cells had been described in tissue by numerous investigators including ... The neuron doctrine is the concept that the nervous system is made up of discrete individual cells, a discovery due to decisive ... Ramón y Cajal's discovery was the decisive evidence for the discontinuity of nervous system and the presence of large number of ...
Journal of the Autonomic Nervous System. 36 (1): 75-84. doi:10.1016/0165-1838(91)90132-M. PMID 1721636. Meister B, Arvidsson U ...
Actions on the parasympathetic nervous system, (the parasympathetic branch of the autonomic nervous system) may cause ... English, Brett A.; Webster, Andrew A. (2012). "Acetylcholinesterase and its Inhibitors". Primer on the Autonomic Nervous System ... thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and ... This is a disease, which is characterized by degeneration of axons in the peripheral and central nervous system. This disease ...
ISBN 978-0-521-31600-2. Levenson RW (1992). "Autonomic nervous system differences among emotions". Psychological Science. 3: 23 ...
"Structure of the Autonomic Nervous System , Boundless Anatomy and Physiology". courses.lumenlearning.com. Retrieved 2019-10-28 ... The sympathetic ganglia, or paravertebral ganglia are autonomic ganglia, of the sympathetic nervous system. Ganglia are 20,000 ... This perception of danger can instigate the fight-or-flight response associated with the sympathetic nervous system. The fight- ... The general rule of interaction of the nerve fibers in the sympathetic nervous system begins at the spinal cord. Here they ...
November 2011). Primer on the Autonomic Nervous System. Geoffrey Burnstock, Phillip A. Low, Julian F.R. Paton (3rd ed.). ... blood pressure but also the insulin resistance components of the metabolic syndrome and cardiac autonomic nervous system tone ... Mishlove, Jeffrey (1988). "Chapter 3". Psi Development Systems. Ballantine. ISBN 978-0-345-35204-0. JOHNSON, CHIP (October 9, ... the TM technique has been introduced to prisoners in the Oregon Correctional System and a research study is underway to record ...
Journal of the Autonomic Nervous System. 75 (1): 16-22. doi:10.1016/S0165-1838(98)00165-9. ISSN 0165-1838. PMID 9935265 - via ...
doi:10.1016/0165-6147(85)90136-1. Watanabe, August M. (1 May 1985). "Digitalis and the autonomic nervous system". Journal of ... Digitalis also has a vagal effect on the parasympathetic nervous system, and as such is used in re-entrant cardiac arrhythmias ... The dependence on the vagal effect means digitalis is not effective when a patient has a high sympathetic nervous system drive ... "Notes on poisoning:Digitalis purpura". Canadian poisonous plants information system. Canadian Biodiversity Information Facility ...
Daly JW (July 2000). "Alkylxanthines as research tools". Journal of the Autonomic Nervous System. 81 (1-3): 44-52. doi:10.1016/ ...
Journal of the Autonomic Nervous System. 72 (2-3): 98-110. doi:10.1016/S0165-1838(98)00094-0. PMID 9851558. Nagase T, Ishikawa ...
This regulation occurs through the sympathetic and parasympathetic system (the autonomic nervous system), and their direct ... Neuroimmunology Parasympathetic nervous system Peripheral nervous system Psychoneuroimmunology Sympathetic nervous system ... Brading, A. (1999). The autonomic nervous system and its effectors. Oxford: Blackwell Science. ISBN 978-0-632-02624-1. Barnéoud ... CS1: long volume value, Autonomic nervous system, Homeostasis, Neurophysiology). ...
Many people affected by MSA experience dysfunction of the autonomic nervous system, which commonly manifests as orthostatic ... ISBN 978-3-540-23735-8. "Autonomic nervous system" at Dorland's Medical Dictionary "Hypotension". The Lecturio Medical Concept ... difficulty coordinating movement and balance Autonomic nervous system dysfunction - impaired automatic body functions, ... The region in question includes the SHC2 gene which, in mice and rats, appears to have some function in the nervous system. The ...
She was the author of many works on Chronaxie and the influence of insulin on the autonomic nervous system and became a ... She obtained her doctorate on the basis of her work The influence of insulin on the vegetative nervous system in 1927. She ... Hurynowicz, J. (1952). The Vestibular System of the Rabbit in Fatigue. Bulletin de la Societe des amis des sciences et des ... Petersburg, Russia, graduating in 1918 summa cum laude, but she "faced a higher education system closed to women." During 1918- ...
These cells respond to signals from the autonomic nervous system to either increase or decrease the heart rate. Pacemaker cells ...
The sympathoadrenal system is a physiological connection between the sympathetic nervous system and the adrenal medulla and is ... Hypoglycemia-associated autonomic failure (HAAF) can occur if left untreated. The sympathoadrenal system activity is ... the brain acts on the central nervous system by crossing the blood-brain barrier and affecting the sympathetic nervous system. ... Fisher, S.J.; Brüning, J.C.; Lannon, S.; Kahn, C.R. (2005). "Insulin Signaling in the Central Nervous System Is Critical for ...
Several areas of the nervous system (such as the autonomic nervous system and numerous regions of the brain) can be affected by ... Dysautonomia (autonomic dysfunction) occurs when Lewy pathology affects the peripheral autonomic nervous system (the nerves ... Lewy pathology affects the peripheral autonomic nervous system; autonomic dysfunction is observed less often in AD, ... Also affected are the hypothalamus, spinal cord and peripheral nervous system-autonomic dysfunction. The European Federation of ...
2002). Innervation of the gastrointestinal tract: Volume 14 of Autonomic nervous system. Taylor & Francis. ISBN 9780415283779. ... Observations in this system have also guided understanding the function of neurons in the central nervous system. The studies ... methods has made the neuronal structure of the enteric nervous system one of the best understood parts of the nervous system in ... His research focuses on the nervous system, specifically how it interacts with the gut to control it, and he has authored or co ...
Hochman, G.; Yechiam, E. (2011). "Loss aversion in the eye and in the heart: The Autonomic Nervous System's responses to losses ... In their review, Yechiam and Hochman (2013) did find a positive effect of losses on performance, autonomic arousal, and ...
A chronic state of impaired venous drainage from the central nervous system, termed chronic cerebrospinal venous insufficiency ... "Safety Alerts for Human Medical Products - Balloon angioplasty devices to treat autonomic dysfunction: FDA Safety Communication ... Italian researcher Paolo Zamboni in 2008 to describe compromised flow of blood in the veins draining the central nervous system ... A similar condition involving the head and neck venous system may cause chronic cerebro-spinal venous insufficiency (CCSVI) and ...
... is a scientific society with a particular focus on clinical aspects of the autonomic nervous system ... International Society for Autonomic Neuroscience Official website Clinical Autonomic Research v t e (Articles needing ... Its official journal, Clinical Autonomic Research, is published by Springer Science+Business Media. ...
... non-sensory nervous system (i.e., the autonomic nervous system), affecting mostly the internal organs such as the bladder ... Vinik AI, Erbas T (2013). "Diabetic autonomic neuropathy". Autonomic Nervous System. Handbook of Clinical Neurology. Vol. 117. ... Autonomic neuropathy is one cause of malfunction of the autonomic nervous system, but not the only one; some conditions ... Testing for small-fiber peripheral neuropathies often relates to the autonomic nervous system function of small thinly- and ...
... and the autonomic nervous system can be voluntarily controlled. These research demonstrations have been one of the major ...
Cytology and Cellular Pathology of the Nervous System. By various authors. Edited by W. Penfield. Three volumes, 1280 pages, ... Penfield's homunculus (neuroanatomic feature first characterized by Penfield in 1937) Penfield syndrome (a form of autonomic ... and long-term memory systems where memories become stored in incorrect systems. There are several ways one can recognize ... It is thought to be a mismatch of the sensory input people receive and the system in which the brain recalls memory. Another ...
... operators for 26 individual life science experiments focusing on the effects of microgravity on the brain and nervous system. ... He received a NASA Young Investigator Award in 1994 for his work in the area of autonomic neurophysiology. Pawelczyk was a co- ... Between 1992 and 1995, he was director of the Autonomic and Exercise Physiology Laboratories at the Institute for Exercise and ... User design group, GASMAP (Gas Analysis System for Metabolic Analysis Physiology); Unit principal investigator for the NASA ...
March 2007). "Prions spread via the autonomic nervous system from the gut to the central nervous system in cattle incubating ... BSE is a transmissible disease that primarily affects the central nervous system; it is a form of transmissible spongiform ... its pathogenesis occurs in areas that reside outside of the nervous system. There was a strong deposition of PrPSc initially ... Disease incidence also appears to correlate with slaughtering practices that led to the mixture of nervous system tissue with ...
... autonomic and enteric nervous systems. Neural pathways regulate brain-body interactions and allow to sense and control its body ... The nervous system consists of central and peripheral nervous systems and coordinates the actions of an animal by transmitting ... The brain-body interactions are supported by peripheral nervous system that connects the CNS to the limbs and organs. These ... Brain-body interactions are patterns of neural activity in the central nervous system to coordinate the activity between the ...
Physiologically, urination involves coordination between the central, autonomic, and somatic nervous systems. In infants, some ... The emission phase of the ejaculatory reflex is under control of the sympathetic nervous system, while the ejaculatory phase is ... Single-male breeding systems-or monogamous societies-tend to show smaller testis size than do multi-male breeding systems or ... It is a passage both for urination and ejaculation of semen (see male reproductive system.) Most of the penis develops from the ...
... autonomic, and central nervous system and somatomotor activity, behavior pattern, sign of tremors, convulsions, salvation, ...
Orthostatic intolerance (OI) is a disorder of the autonomic nervous system (a subcategory of dysautonomia) characterized by the ... NE is a part of the sympathetic nervous system. Dysregulation of the removal of norepinephrine by NET is associated with many ... Norepinephrine transporters are confined to the neurons of the sympathetic system, and those innervating the adrenal medulla, ... and autonomic disorders. Recently discovered mechanisms of the NET, including the ability to act reversibly and as an ion ...
... the peripheral nervous system has a greater capacity for healing than the central nervous system. Signs (observed by a ... Other autonomic functions may also be disrupted. For example, problems with body temperature regulation mostly occur in ... which results from an interruption in output from the sympathetic nervous system responsible for maintaining muscle tone in the ... because inhibitory signals from the brain cannot pass the lesion to dampen the excitatory sympathetic nervous system response. ...
Spinal cord injuries or nervous system disorders are additional causes of overflow incontinence. In men, benign prostatic ... Autonomic neuropathy from diabetes or other diseases (e.g. Multiple sclerosis) can decrease neural signals from the bladder ( ... Lesions affecting sacral segments or peripheral autonomic fibres result in atonic bladder with loss of sphincteric coordination ...
The neuroscience of aging is the study of the changes in the nervous system that occur with ageing. Aging is associated with ... become significant enough to detect even with autonomic nervous responses to emotionally charged stimuli. Aging is also ... many changes in the central nervous system, such as mild atrophy of the cortex that is considered non-pathological. Aging is ... Diseases commonly associated with old age include Multiple system atrophy Parkinson's disease Alzheimer's disease Stroke. ...
... particularly of the autonomic nervous system. A very rare syndrome with isolated congenital insensitivity to pain has been ... A much smaller number of people are insensitive to pain due to an inborn abnormality of the nervous system, known as " ... Insensitivity to pain may also result from abnormalities in the nervous system. This is usually the result of acquired damage ... Neuropathic pain is caused by damage or disease affecting any part of the nervous system involved in bodily feelings (the ...
It is responsible for regulating several basic functions of the autonomic nervous system, including respiration, cardiac ... Nageotte earned his medical degree in 1893, and specialized in research of the nervous system, and the importance of ... During the sensory system examination, pain and thermal senses of the patient were decreased on the left side of the body and ... In the motor system examination, the left upper and lower extremity muscle power were 3/5 level and her Babinski reflex was ...
It is mainly supplied by sensory afferents and the sympathetic nervous system. The scrotum. Schematic drawing of a cross- ... and Sensory and Autonomic Nerves". The Journal of Urology. 195 (6): 1841-1847. doi:10.1016/j.juro.2015.11.041. ISSN 0022-5347. ...
... autonomic, motor and central nervous system symptoms. Answering the statements a person should indicate how much each statement ...
2002). "Chronic fatigue syndrome: what role does the autonomic nervous system play in the pathophysiology of this complex ...
These nerve fibres are part of the autonomic nervous system, part of the 'fight or flight' system. "The Open Door Web Site : ... v t e (Nerves, Autonomic nervous system, All stub articles, Neuroanatomy stubs). ... It is acted on by the nervous system, as well as hormones in the blood, and venous return: the amount of blood being returned ...
... conditions in which the autonomic nervous system does not function properly. In primary dysautonomias, the autonomic ... where the dysfunction of the autonomic nervous system is believed to be caused by another disease (e.g. diabetes). Diseases ... when believed to result from a chronic condition characterized by degeneration of the autonomic nervous system, or where ... A Textbook of Clinical Disorders of the Autonomic Nervous System. Oxford University Press. ISBN 978-0-19-856634-2. (Peripheral ...
The autonomic nervous system (ANS), of which sudomotor nerves are an integral part, is the primary extrinsic control mechanism ... See also sweat gland, eccrine sweat gland and Autonomic nervous system. The ESC measurement relies on the particularities of ... These sweat glands are innervated by the sympathetic autonomic peripheral nervous system. According to Sato, both adrenergic ... "A Simple and Accurate Method to Assess Autonomic Nervous System through Sudomotor Function". In Yurish, Sergey (ed.). Advances ...
... these cells will slowly depolarize by themselves and do not need any outside innervation from the autonomic nervous system to ... rate is constantly modified by the activity of sympathetic and parasympathetic nerve fibers via the autonomic nervous system, ... Sometimes a secondary pacemaker sets the pace, if the SA node is damaged or if the electrical conduction system of the heart ... Further down the electrical conducting system of the heart is the Bundle of His. The left and right bundle branches, and the ...
Dysautonomia is a disorder of the autonomic nervous system, which controls functions such as breathing and heartbeat. Read more ... Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your ... Article: Autonomic Dysfunction Related to Postacute SARS-CoV-2 Syndrome. * Autonomic Nervous System Disorders -- see more ... ClinicalTrials.gov: Autonomic Nervous System Diseases (National Institutes of Health) * ClinicalTrials.gov: Hypotension, ...
Autonomic Nervous System Diseases[majr:noexp] AND humans[mh] AND english[la] AND last 1 Year [edat] NOT (letter[pt] OR case ... Autonomic Nervous System Diseases[majr:noexp] AND humans[mh] AND english[la] AND last 1 Year [edat] NOT (letter[pt] OR case ... 33RD International Symposium on the Autonomic Nervous System. [No authors listed] [No authors listed] Clin Auton Res. 2022 Oct; ... Updates on the Diagnosis and Treatment of Peripheral Autonomic Neuropathies. Lamotte G, Sandroni P. Lamotte G, et al. Curr ...
autonomic nervous system -- RDoC Element. Type of Element: Circuit. The following construct(s)/subconstruct(s) refer to this ... Home , Research , Research Funded by NIMH , Research Domain Criteria (RDoC) , Units of Analysis , Circuits , autonomic nervous ...
The autonomic nervous system (ANS) is a very complex, multifaceted neural network that maintains internal physiologic ... encoded search term (Autonomic Nervous System Anatomy) and Autonomic Nervous System Anatomy What to Read Next on Medscape ... The autonomic nervous system (ANS) consists of the sympathetic and parasympathetic nervous system. The sympathetic nervous ... The central autonomic network is a complex network in the central nervous system (CNS) that integrates and regulates autonomic ...
The Autonomic nervous system : summary  World Health Organization. Office of Research Policy and Cooperation (‎World Health ... The autonomic nervous system / edited by C. L. Bolis and J. Licinio  ... "Autonomic Nervous System". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. Z. * 0-9 ...
New findings related to autonomic nervous system (ANS) functions may reveal some brain functions, since they can be observed by ... Autonomic nervous system response patterns correlate with mental imagery Physiol Behav. 1992 May;51(5):1021-7. doi: 10.1016/ ... New findings related to autonomic nervous system (ANS) functions may reveal some brain functions, since they can be observed by ... Imagery contents influence autonomic responses, thus making it comparable to real activity. Therefore, by using two shooting ...
The purpose of the meeting is to identify the role of the autonomic nervous system in metabolic disease, educate scientific ... Autonomic Nervous System: Role in the Regulation of Peripheral Metabolism and Pathophysiology of Metabolic Disease. Sept. 20. ... The autonomic nervous system (ANS) plays a critical role in the regulation of physiological responses required for maintaining ... Session 1: Overview of the Role of the Autonomic Nervous System (ANS) in Peripheral Metabolism Moderator: Karen Teff, Ph.D. ...
Autonomic nerves are attractive targets for medical therapies using electroceutical devices because of the potential for ... Electroceutical Targeting of the Autonomic Nervous System Charles C Horn 1 2 3 , Jeffrey L Ardell 4 5 , Lee E Fisher 6 7 ... Electroceutical Targeting of the Autonomic Nervous System Charles C Horn et al. Physiology (Bethesda). 2019. . ... Device therapy to modulate the autonomic nervous system to treat heart failure. Lopshire JC, Zipes DP. Lopshire JC, et al. Curr ...
The autonomic nervous system (ANS) (or visceral nervous system) is the part of the peripheral nervous system that acts as a ... motor system (comprised of the parasympathetic nervous system and sympathetic nervous system), and the enteric nervous system. ... Articles on Autonomic nervous system in N Eng J Med, Lancet, BMJ ... FDA on Autonomic nervous system CDC on Autonomic nervous system ... Some typical actions of the sympathetic and parasympathetic systems are listed below: Sympathetic nervous system. Promotes a " ...
Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of ... The purpose of this Notice is to announce the expiration of PA-18-891, Elucidating the Role of the Autonomic Nervous System in ... Notice of Expiration of PA-18-891, Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic ... Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of ...
Awakening Patterns of Behavior: Embodying the Autonomic Nervous System. A Body-Mind Centering® Workshop. with Bonnie Bainbridge ... These stories are then recorded by and stored in the templates of our autonomic nervous system. ... and dialogue to explore basic processes stored in our tissues and autonomic nervous system. This workshop is for people ...
Autonomic Nervous System Type. This will be reflected in your Metabolic Dietary Type and mineral ... Autonomic Nervous System Balance (Extreme Positive). You have a highly positive (Sympathetic Dominant) Autonomic Nervous System ... Usually Parasympathetic nervous system: Portion of the autonomic nervous system that is generally associated with increasing ... The autonomic nervous system controls most of the involuntary activities of your body. It regulates your metabolism and keeps ...
Autonomic nervous system dysfunction in mild traumatic brain injury: a review of related pathophysiology and symptoms.. ... Autonomic nervous system dysfunction in mild traumatic brain injury: a review of related pathophysiology and symptoms. ... The autonomic nervous system (ANS) plays a vital role in maintaining and regulating homeostatic processes. ANS dysfunction has ... Autonomic nervous system dysfunction in mild traumatic brain injury: a review of related pathophysiology and symptoms. ...
ICD-10 code T44.994S for Poisoning by other drug primarily affecting the autonomic nervous system, undetermined, sequela is a ... Poisoning by other drug primarily affecting the autonomic nervous system, undetermined, sequela ... ICD-10-CM Code for Poisoning by other drug primarily affecting the autonomic nervous system, undetermined, sequela T44.994S ICD ... code T44.994S for Poisoning by other drug primarily affecting the autonomic nervous system, undetermined, sequela is a medical ...
Autonomic failure: a text book of clinical disorders of the autonomic nervous system. Oxford, Oxford University Press, 1992:312 ... Effect of yogic intervention on the autonomic nervous system in the patients with coronary artery disease: a randomized ... These tests were helpful in assessment of the reactivity of divisions of the autonomic nervous system, i.e. tests for ... Effect of yogic intervention on the autonomic nervous system in the patients with coronary artery disease: a randomized ...
Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type ... Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type ... Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type ...
Overview of the Autonomic Nervous System - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD ... Anatomy of the Autonomic Nervous System The autonomic nervous system receives input from parts of the central nervous system ( ... Physiology of the Autonomic Nervous System The autonomic nervous system controls blood pressure (BP), heart rate, body ... see figure The autonomic nervous system The autonomic nervous system ). ...
... Georg Seifert a. , ... RMT causes specific and marked stimulation of the autonomic nervous system. Use of a medicinal aromatic oil had only a ... Rhythmical massage improves autonomic nervous system function: A single-blind randomised controlled trial. Journal of ... The authors aimed to investigate the physiological action of RMT on the cardiovascular system by analysing heart rate ...
Onward. Upward. Inward.. Thrive Global © 2023. ...
... including central nervous system irritability (e.g., tremors), gastrointestinal dysfunction (e.g., feeding difficulties), and ... including NAS surveillance systems. The Comprehensive Addiction and Recovery Act of 2016§§ extends the federal grant program ...
These exercises stimulate your body to become relaxed and content inside. Everything you need for a trip is getting ready to accompany and support ...
your nervous systems conductor.. Leave a Comment / Physical Therapy, Wellness, Yoga / By Christine Carr ... This post discusses the vagus nerve and its influence over the parasympathetic nervous system and your health ...
The autonomic nervous system at high altitude. Hainsworth, Roger; Drinkhill, Mark J; Rivera-Chira, Maria. Afiliação *Hainsworth ... The autonomic nervous system at high altitude. ...
Autonomic Nervous System. Dry mouth. Cardiovascular. Bradycardia, palpitations and other rhythm disturbances, cold extremities ... Central Nervous System Reversible mental depression progressing to catatonia, hallucinations, an acute reversible syndrome ... Central Nervous System. Dizziness, , vertigo, , headache, paresthesia, hypoesthesia, hyperesthesia, somnolence, , anxiety/ ...
Autonomic Nervous System:. Hypertension and fluctuations in blood pressure have been reported with fluphenazine hydrochloride. ... Fluphenazine hydrochloride has activity at all levels of the central nervous system as well as on multiple organ systems. The ... Central Nervous System:. The side effects most frequently reported with phenothiazine compounds are extrapyramidal symptoms ... Moreover, it should be remembered that reduced amounts of anesthetics or central nervous system depressants may be necessary. ...
OUTSIDE THE CENTRAL NERVOUS SYSTEM: THE ENTERIC & AUTONOMIC NERVOUS SYSTEMS * OVERALL ORGANIZATION OF THE AUTONOMIC NERVOUS ... and enteric systems. This chapter will discuss the autonomic and enteric nervous systems (ENS). The autonomic nervous system ... The enteric nervous system is the nervous system of digestion. Previously, the ENS was considered part of the autonomic nervous ... Understand the organs controlled by the autonomic nervous system and notable disorders associated with autonomic nervous system ...
OUTSIDE THE CENTRAL NERVOUS SYSTEM: THE ENTERIC & AUTONOMIC NERVOUS SYSTEMS * OVERALL ORGANIZATION OF THE AUTONOMIC NERVOUS ... and enteric systems. This chapter will discuss the autonomic and enteric nervous systems (ENS). The autonomic nervous system ... The enteric nervous system is the nervous system of digestion. Previously, the ENS was considered part of the autonomic nervous ... Understand the organs controlled by the autonomic nervous system and notable disorders associated with autonomic nervous system ...
Yoga trains the autonomic nervous system to be more efficient. ... Our autonomic nervous system really developed back when we ... Stress is connected to the Autonomic Nervous System. Yoga helps with stress by making our Autonomic Nervous System more ... How does Yoga Retrain the Autonomic Nervous System?. Yoga creates a battle field between your sympathetic nervous system and ... Stretching also activates the parasympathetic system.. *Heat has also been proven to help regulate the Autonomic Nervous System ...
  • The neurotransmitter for preganglionic sympathetic and parasympathetic nervous system (PNS) as well as postganglionic parasympathetic nervous system is acetylcholine (ACh). (medscape.com)
  • Although new techniques in neuroscience and molecular genetics are being used to elucidate the neuroanatomy and function of the ANS, much remains unknown regarding the contribution of the parasympathetic and sympathetic nervous systems in the regulation of glucose and lipid homeostasis. (nih.gov)
  • Overall, the role of the parasympathetic and sympathetic nervous systems in the etiology and pathophysiology of metabolic diseases remains a scientific area ripe for development. (nih.gov)
  • Its main components are its sensory system, motor system (comprised of the parasympathetic nervous system and sympathetic nervous system ), and the enteric nervous system . (wikidoc.org)
  • The preganglionic cell bodies of the parasympathetic system are located in the brain stem and sacral portion of the spinal cord. (msdmanuals.com)
  • Understand the antagonism between the sympathetic and parasympathetic divisions of the autonomic nervous systems. (mhmedical.com)
  • See how the sympathetic and parasympathetic divisions of the autonomic nervous system operate at the spinal cord level. (mhmedical.com)
  • The autonomic nervous system consists of sympathetic and parasympathetic branches that generally have opposite effects on organs such as the heart and lungs. (mhmedical.com)
  • The sympathetic system activates the fight-or-flight response, whereas parasympathetic activity promotes homeostatic functions such as digestion and the immune system. (mhmedical.com)
  • It is a positive feedback loop and without conditioning your parasympathetic system to take over, your body begins to be in a constant state of stress. (masteringhealthandfitness.com)
  • Our lives throw so much stress our way, that our brains never activate the "relax" or parasympathetic nervous system. (masteringhealthandfitness.com)
  • Yoga Trains our bodies to use the sympathetic system when needed, and retrains our parasympathetic system to take over when we aren't actually in fight or flight. (masteringhealthandfitness.com)
  • Yoga creates a battle field between your sympathetic nervous system and parasympathetic system. (masteringhealthandfitness.com)
  • Breathing activates the parasympathetic system so you start and end activating your "relax" system. (masteringhealthandfitness.com)
  • Stretching also activates the parasympathetic system. (masteringhealthandfitness.com)
  • After making it through a Bikram yoga class where your Autonomic Nervous System Battles between Sympathetic and Parasympathetic for 90 min we begin to condition ourselves to handle sympathetic responses better and shut them off quickly by activating our parasympathetic system. (masteringhealthandfitness.com)
  • It is composed of sympathetic and parasympathetic systems which work in opposition to each other. (abcbooksllc.com)
  • This classic chart ofThe Autonomic Nervous System shows the pathways of both the parasympathetic and the sympathetic systems. (abcbooksllc.com)
  • Sweating is the one exception that acts just like the parasympathetic nervous system in its organization of the neurotransmitters and target receptors. (byui.edu)
  • One thing that you'll come to realize is that the high frequency of the spectral power of heart rate variability is associated with the parasympathetic system, whereas the low frequency is associated with both the parasympathetic and the sympathetic nervous system. (labfront.com)
  • So the parasympathetic nervous system involves the acetylcholine coming from the post ganglion of the power to set the sympathetic nervous system binding to the amp to the muscarinic receptor, activating the G protein, which then subsequently activates this potassium-associated acetylcholine channel. (labfront.com)
  • So if there was no intervention from either the sympathetic or the vagal system or the parasympathetic system, you would have this type of automaticity of the electrical potential. (labfront.com)
  • Together, these parameters can aid the physician to obtain detailed insights in the dynamics of sympathetic and parasympathetic innervation of the human cardiovascular system. (medtach.com)
  • Physiologists have discovered two divisions of the autonomic nervous system, i.e., sympathetic division and parasympathetic division. (sweducarebd.com)
  • The parasympathetic system is responsible for regulating sleep and digestion. (doxyva.com)
  • Investigating the possible mechanisms of autonomic dysfunction post-COVID-19. (nih.gov)
  • Autonomic Dysfunction Related to Postacute SARS-CoV-2 Syndrome. (nih.gov)
  • The etiology of autonomic dysfunction can be primary or idiopathic and secondary causes. (medscape.com)
  • In addition, autonomic dysfunction is associated with various medications. (medscape.com)
  • Clinical research in this area is severely hampered by a paucity of tools and/or methodologies available to assess tissue-specific autonomic function or dysfunction. (nih.gov)
  • Autonomic nervous system dysfunction in mild traumatic brain injury: a review of related pathophysiology and symptoms. (iasp-pain.org)
  • NAS usually appears within 48-72 hours of birth with a constellation of clinical signs, including central nervous system irritability (e.g., tremors), gastrointestinal dysfunction (e.g., feeding difficulties), and temperature instability ( 1 ) ( Box 1 ). (cdc.gov)
  • Understand the organs controlled by the autonomic nervous system and notable disorders associated with autonomic nervous system dysfunction. (mhmedical.com)
  • People may also experience disturbances of the autonomic nervous system that manifest as problems with digestion, respiration, salivation as well as excessive sweating, bladder dysfunction, or sexual dysfunction. (nih.gov)
  • See how the neurotransmitters acetylcholine (ACh) and norepinephrine mediate autonomic nervous system control. (mhmedical.com)
  • Another drug mechanism that can affect the autonomic nervous system involves inhibition of enzymes that break down the normally secreted neurotransmitters. (byui.edu)
  • The autonomic nervous system works alongside your body's neurotransmitters and hormones in order to ensure that your body is working correctly. (doxyva.com)
  • In order to communicate with one another, the two branches of the autonomic nervous system use special chemical hormones, called neurotransmitters. (doxyva.com)
  • If something goes wrong with these neurotransmitters, messages from the body to the autonomic nervous system can easily be confused. (doxyva.com)
  • Along with neurotransmitters, your autonomic nervous system also relies on hormones in order to stimulate certain bodily functions. (doxyva.com)
  • To serve as a case-based, interactive auto-tutorial on the anatomy, physiology, and pharmacology of the autonomic nervous system (ANS). (bvsalud.org)
  • Autonomic nervous system disorders can occur alone or as the result of another disease, such as Parkinson's disease , alcoholism and diabetes. (medlineplus.gov)
  • Some autonomic nervous system disorders get better when an underlying disease is treated. (medlineplus.gov)
  • Given the complex nature of this system, a stepwise approach to autonomic disorders is required for proper understanding. (medscape.com)
  • Because the autonomic nervous system maintains internal physiologic homeostasis, disorders of this system can be present with both central as well as peripheral nervous system localization. (medscape.com)
  • In addition to the acquired causes, inherited disorders like hereditary sensory-autonomic neuropathy (HSAN), familial amyloid polyneuropathy (FAP), Tangier disease, and Fabry disease also exist. (medscape.com)
  • Disorders of the autonomic nervous system cause autonomic insufficiency or failure and can affect any system of the body. (msdmanuals.com)
  • The neurotransmitter for the postganglionic sympathetic nervous system (innervating sweat glands) is also acetylcholine, whereas that for the remaining postganglionic sympathetic nervous system is norepinephrine (NE). (medscape.com)
  • But, that is because general sweating is the one exception in the sympathetic nervous system that has acetylcholine in the second synapse between neuron and target organ. (byui.edu)
  • Updates on the Diagnosis and Treatment of Peripheral Autonomic Neuropathies. (nih.gov)
  • Besides nerve localization in the peripheral nervous system, it occurs in diseases of the presynaptic neuromuscular junction such as botulism and myasthenic syndrome. (medscape.com)
  • Afferent fibers relay sensory and metabolic information to the central nervous system, while efferent fibers provide the major neural pathway from the brain to peripheral tissues. (nih.gov)
  • The autonomic nervous system ( ANS ) (or visceral nervous system ) is the part of the peripheral nervous system that acts as a control system, maintaining homeostasis in the body. (wikidoc.org)
  • The sensory arm is made of " primary visceral sensory neurons" found in the peripheral nervous system (PNS), in "cranial sensory ganglia": the geniculate , petrosal and nodose ganglia, appended respectively to cranial nerves VII, IX and X. These sensory neurons monitor the levels of carbon dioxide, oxygen and sugar in the blood, arterial pressure and the chemical composition of the stomach and gut content. (wikidoc.org)
  • This Funding Opportunity Announcement (FOA) will be published under a new FOA Number, PAR-18-898 , Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of Novel Tools and Methodologies (RC2 Clinical Trial Optional). (nih.gov)
  • The visceral system of the Peripheral Nervous System is known as the Autonomic Nervous System. (sweducarebd.com)
  • The sensory (afferent) and motor (efferent) nerves connecting the body's surface with the central nervous system constitute the peripheral nervous system. (sweducarebd.com)
  • Autonomic failure is seen in multiple system atrophy, pure or progressive autonomic failure, Parkinson and other neurodegenerative diseases, metabolic diseases such as Wernicke and cobalamin deficiency, diabetes mellitus, hyperlipidemia, trauma, vascular diseases, neoplastic diseases, and multiple sclerosis . (medscape.com)
  • Acetylcholinesterase inhibitors do affect the sympathetic nervous system in the first synapse but not the second synapse where norepinephrine is released. (byui.edu)
  • The sympathetic nervous system, on the other hand, operates through norepinephrine or epinephrine that binds to the beta one receptors. (labfront.com)
  • Norepinephrine is a hormone released by your adrenal gland and controlled by your sympathetic nervous system. (doxyva.com)
  • The autonomic nervous system receives inputs from receptors in glands and cardiac and smooth muscle and sends motor commands to those areas. (mhmedical.com)
  • Together the two systems control cardiac muscles, smooth muscles, and glands. (abcbooksllc.com)
  • Autonomic and Vascular Responses during Reactive Hyperemia in Healthy Individuals and Patients with Sickle Cell Anemia. (nih.gov)
  • Imagery contents influence autonomic responses, thus making it comparable to real activity. (nih.gov)
  • The autonomic nervous system (ANS) plays a critical role in the regulation of physiological responses required for maintaining metabolic homeostasis. (nih.gov)
  • The enteric nervous system is the nervous system of digestion. (mhmedical.com)
  • The autonomic actions energising sweat glands lead to perspiration, which produces changes in the electrical properties of the skin. (sweducarebd.com)
  • The autonomic nervous system (ANS) is a very complex, multifaceted neural network that maintains internal physiologic homeostasis. (medscape.com)
  • The autonomic nervous system regulates physiologic processes. (msdmanuals.com)
  • The researchers measured changes in skin conductance (how fast the skin conducts electricity), a known indicator of autonomic arousal. (nih.gov)
  • Small myelinated fibers transmit preganglionic autonomic efferents (B fibers) and somatic afferents (A delta fibers). (medscape.com)
  • Unmyelinated (C) fibers transmit postganglionic autonomic efferents as well as somatic and autonomic afferents. (medscape.com)
  • Short- and long-term effects of massage on autonomic regulation differed significantly among the three groups. (jcimjournal.com)
  • Vertebrate ganglia are the control centers for the autonomic and enteric nervous systems. (mhmedical.com)
  • Having an understanding of the ANS and its particular receptors located on effectors and the drugs that activate or block these receptors will assist your understanding of the actions of this system. (byui.edu)
  • The eye has multiple autonomic functions controlled by several autonomic receptors. (byui.edu)
  • The ANS is the part of the nervous system that regulates processes in the body that we do not consciously control, such as our breathing, heartbeat, and digestion. (nih.gov)
  • Autonomic and autacoid pharmacology. (who.int)
  • In this workshop, we will use movement, touch, consciousness, and dialogue to explore basic processes stored in our tissues and autonomic nervous system. (bodymindcentering.com)
  • For some reason, the autonomic nervous system doesn't trigger the release of enough growth hormone to help repair muscles and tissues. (doxyva.com)
  • Autonomic nerves are attractive targets for medical therapies using electroceutical devices because of the potential for selective control and few side effects. (nih.gov)
  • Results of search for 'su:{Autonomic nervous system. (who.int)
  • The goal for this article remains focused at step III on the anatomy of the autonomic nervous system, as follows. (medscape.com)
  • Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. (medlineplus.gov)
  • The Autonomic Nervous System is the involuntary functioning part of the nervous system that controls the internal organs of the body. (abcbooksllc.com)
  • How a person perceives and evaluates stimuli involving actual or prospective pain is an important component in the autonomic nervous system's (ANS) response to such stimuli, according to a study conducted by researchers in the Intramural Program of the National Center for Complementary and Integrative Health (NCCIH). (nih.gov)
  • The ANS is part of the response to pain, which also includes "nociception"-the nervous system's encoding and processing of a "noxious" (an actually or potentially harmful) stimulus, such as a hot stove or freezing water. (nih.gov)
  • your nervous system's conductor. (trptwellness.com)
  • The autonomic nervous system (ANS) plays a vital role in maintaining and regulating homeostatic processes. (iasp-pain.org)
  • The brain also interacts with an extended nervous system outside the brain that controls body metabolic processes such as respiration, heart rate, temperature, and digestion. (mhmedical.com)
  • The activity of autonomic ganglionic neurons is modulated by "preganglionic neurons" (also called improperly but classically "visceral motoneurons") located in the central nervous system. (wikidoc.org)
  • The preganglionic cell bodies of the sympathetic system are located in the intermediolateral horn of the spinal cord between T1 and L2 or L3. (msdmanuals.com)
  • The autonomic nervous system receives input from parts of the central nervous system (CNS) that process and integrate stimuli from the body and external environment. (msdmanuals.com)
  • The autonomic nervous system is an important part of your body's central nervous system (CNS). (doxyva.com)
  • Understand the organization and projections of the cephalic portion of the autonomic nervous system. (mhmedical.com)
  • This explains that when the central nervous system (CNS) is damaged experimentally or by accident above that level, a vegetative life is still possible, whereby cardiovascular, digestive and respiratory functions are adequately regulated. (wikidoc.org)
  • Fluphenazine hydrochloride has activity at all levels of the central nervous system as well as on multiple organ systems. (nih.gov)
  • These systems interact with the central nervous system (CNS) in the brainstem and hypothalamus. (mhmedical.com)
  • The synapse of the system is situated outside of both the spinal column and central nervous system. (sweducarebd.com)
  • PD's effects on the central nervous system are both chronic (meaning they persist) and progressive (meaning the symptoms grow worse over time). (nih.gov)
  • There are two parts to your autonomic nervous system, which are referred to as branches. (doxyva.com)
  • Les patients ont été répartis aléatoirement en deux groupes, le premier bénéficiant d'une intervention basée sur le yoga contrairement au second. (who.int)
  • Marca Sipski is serving as president of the American Spinal Cord Injury Association (ASIA) and is active in the development of standards for autonomic nervous system function in spinal cord injury (SCI). (nih.gov)
  • The authors aimed to investigate the physiological action of RMT on the cardiovascular system by analysing heart rate variability (HRV). (jcimjournal.com)
  • The nervous system is responsible for communicating vital messages to various parts of your body, helping you to act and react, see, touch, taste, and feel. (doxyva.com)
  • It helps to control a variety of different organs in your body as well as numerous bodily systems. (doxyva.com)
  • On one hand, you are exercising: increasing your heart rate, blood pressure, and breathing rate activating your sympathetic system. (masteringhealthandfitness.com)
  • The Autonomic Testing (AT) software application enables the Baroreceptor Sensitivity (BRS) and various Heart Rate Variability (HRV) parameters on a Finapres ® NOVA Plus with an ECG module. (medtach.com)
  • Heart rate and cardiovascular function are regulated by the autonomic nervous system. (cdc.gov)
  • Heart rate variability (HRV) as a marker reflects the activity of autonomic nervous system. (cdc.gov)
  • We still face situations that stimulate our Sympathetic Nervous System (the fight or flight system), they just aren't in animal form. (masteringhealthandfitness.com)
  • Once upon a time, our autonomic nervous systems sent us into fight-or-flight mode when we perceived danger - often before our conscious minds were even aware of a predator. (wellbodymindheartspirit.com)
  • New findings related to autonomic nervous system (ANS) functions may reveal some brain functions, since they can be observed by real time analysis. (nih.gov)