Autonomic Denervation
Autonomic Nervous System Diseases
Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.
Sino-aortic denervation augments the increase in blood pressure seen during paradoxical sleep in the rat. (1/71)
Using a computer assisted telemetric system, we have re-examined the effect of sino-aortic denervation (SAD) on the changes in arterial blood pressure (AP) and heart rate (HR) during sleep in the rat suitably recovered from the operation. Eight 1 hourly polygraphic recordings were performed 4 weeks after the initial SAD surgery. In the SAD rats, the increase in AP during paradoxical sleep (PS) was much larger than that in sham-operated rats. HR in the SAD rats increased on-going from slow-wave sleep to PS, but it showed no change in sham-operated rats. The present study suggests that chronic SAD causes the enhanced AP increase during PS concomitantly with the persistent hypertension and tachycardia across sleep-wake states. (+info)Autonomic control of skeletal muscle blood flow at the onset of exercise. (2/71)
The purpose of this study was to determine whether the autonomic nervous system is involved in skeletal muscle vasodilation at the onset of exercise. Mongrel dogs (n = 7) were instrumented with flow probes on both external iliac arteries. Before treadmill exercise at 3 miles/h, 0% grade, hexamethonium (10 mg/kg) and atropine (0.2 mg/kg) or saline was infused intravenously. Ganglionic blockade increased resting heart rate from 87 +/- 5 to 145 +/- 8 beats/min (P < 0.01) and reduced mean arterial pressure from 100 +/- 4 to 88 +/- 5 mmHg (P < 0.01). During steady-state exercise, heart rate was unaffected by ganglionic blockade (from 145 +/- 8 to 152 +/- 5 beats/min), whereas mean arterial pressure was reduced (from 115 +/- 4 to 72 +/- 4 mmHg; P < 0.01). Immediate and rapid increases in iliac blood flow and conductance occurred with initiation of exercise with or without ganglionic blockade. Statistical analyses of hindlimb conductance at 5-s intervals over the first 30 s of exercise revealed a statistically significant difference between the control and ganglionic blockade conditions at 20, 25, and 30 s (P < 0.01) but not at 5, 10, and 15 s of exercise. Hindlimb conductance at 1 min of exercise was 9.21 +/- 0.68 and 11.82 +/- 1.32 ml. min(-1). mmHg(-1) for the control and ganglionic blockade conditions, respectively. Because ganglionic blockade did not affect the initial rise in iliac conductance, we concluded that the autonomic nervous system is not essential for the rapid vasodilation in active skeletal muscle at the onset of exercise in dogs. Autonomic control of skeletal muscle blood flow during exercise is manifested through vasoconstriction and not vasodilation. (+info)The influence of acute hypoxia and carotid body denervation on thermoregulation during non-rapid eye movement sleep in the developing lamb. (3/71)
We investigated the influence of ambient temperature on the thermoregulatory response to hypoxia in developing lambs before (at 4 and 14 days of age) and after (17 and 30 days of age) carotid body denervation (CBD). Lambs were studied during non-rapid eye movement sleep at thermoneutral (23-15 C) and cool (10-5 C) ambient temperatures, during normoxia and acute hypoxia (inspired oxygen content of 13 %). Measurements of oxygen consumption, arterial partial pressures of O2 and CO2, colonic temperature, incidence of shivering and plasma concentrations of thyroid hormones, cortisol, insulin and glucose were made under each condition. Oxygen consumption was higher at cool compared with thermoneutral ambient temperatures and decreased during hypoxia during cooling at all stages. At 4 days of age, only one lamb shivered during cooling in normoxia, but 4 out of 12 lambs shivered during hypoxia and colonic temperature fell, significantly, by 0.2 C. At 14 days, 8 out of 12 lambs shivered during cooling, of which 6 continued to shiver during hypoxia but colonic temperature did not change significantly. Plasma triiodothyronine concentrations increased on cooling at 4 and 14 days, an affect that was inhibited by hypoxia at 4, but not 14 days of age. At 17 days of age, i.e. post-CBD, plasma thyroid hormone concentrations and oxygen consumption were lower during cold exposure compared with intact lambs at 14 days of age. In CBD lambs, imposing further hypoxia resulted in colonic temperature falling 0. 6 C during cooling, with only 2 out of 10 lambs shivering. Plasma glucose and insulin, but not cortisol, concentrations decreased during hypoxia, irrespective of age or CBD. It is concluded that hypoxia has an important influence on metabolism and thermoregulation, which is modulated by age and environmental conditions. Compromised carotid body function, in lambs older than 2 weeks of age, can result in severe hypoxia and thermoregulatory dysfunction even with modest environmental cooling. (+info)Ileal short-chain fatty acids inhibit gastric motility by a humoral pathway. (4/71)
The aim of this study was to evaluate the nervous and humoral pathways involved in short-chain fatty acid (SCFA)-induced ileal brake in conscious pigs. The role of extrinsic ileal innervation was evaluated after SCFA infusion in innervated and denervated Babkin's ileal loops, and gastric motility was measured with strain gauges. Peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) concentrations were evaluated in both situations. The possible involvement of absorbed SCFA was tested by using intravenous infusion of acetate. Ileal SCFA infusion in the intact terminal ileum decreased the amplitude of distal and terminal antral contractions (33 +/- 1.2 vs. 49 +/- 1.2% of the maximal amplitude recorded before infusion) and increased their frequency (1.5 +/- 0.11 vs. 1.3 +/- 0.10/min). Similar effects were observed during SCFA infusion in ileal innervated and denervated loops (amplitude, 35 +/- 1.0 and 34 +/- 0. 8 vs. 47 +/- 1.3 and 43 +/- 1.2%; frequency, 1.4 +/- 0.07 and 1.6 +/- 0.06 vs. 1.1 +/- 0.14 and 1.0 +/- 0.12/min). Intravenous acetate did not modify the amplitude and frequency of antral contractions. PYY but not GLP-1 concentrations were increased during SCFA infusion in innervated and denervated loops. In conclusion, ileal SCFA inhibit distal gastric motility by a humoral pathway involving the release of an inhibiting factor, which is likely PYY. (+info)c-Fos expression in the midbrain periaqueductal gray during static muscle contraction. (5/71)
The periaqueductal gray (PAG) of the midbrain is involved in the autonomic regulation of the cardiovascular system. The purpose of this study was to determine if static contraction of the skeletal muscle, which increases arterial blood pressure and heart rate, activates neuronal cells in the PAG by examining Fos-like immunoreactivity (FLI). Muscle contraction was induced by electrical stimulation of the L7 and S1 ventral roots of the spinal cord in anesthetized cats. An intravenous infusion of phenylephrine (PE) was used to selectively activate arterial baroreceptors. Extensive FLI was observed within the ventromedial region (VM) of the rostral PAG, the dorsolateral (DL), lateral (L), and ventrolateral (VL) regions of the middle and caudal PAG in barointact animals with muscle contractions, and in barointact animals with PE infusion. However, muscle contraction caused a lesser number of FLI in the VM region of the rostral PAG, the DL, L, and VL regions of the middle PAG and the L and VL regions of the caudal PAG after barodenervation compared with barointact animals. Additionally, the number of FLI in the DL and L regions of the middle PAG was greater in barodenervated animals with muscle contraction than in barodenervated control animals. Thus these results indicated that both muscle receptor and baroreceptor afferent inputs activate neuronal cells in regions of the PAG during muscle contraction. Furthermore, afferents from skeletal muscle activate neurons in specific regions of the PAG independent of arterial baroreceptor input. Therefore, neuronal cells in the PAG may play a role in determining the cardiovascular responses during the exercise pressor reflex. (+info)Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting. (6/71)
In response to insulin, a hormone [hepatic insulin sensitizing substance (HISS)] is released from the liver to stimulate glucose uptake in skeletal muscle but not liver or gut. The aim was to characterize dynamic control of HISS action in response to insulin and regulation of release by hepatic parasympathetic nerves. Insulin action was assessed by the rapid insulin sensitivity test, where the index is the glucose required (mg/kg) to maintain euglycemia after a bolus of insulin. Blocking HISS release by interruption of the hepatic parasympathetic nerves by surgical denervation, atropine, or blockade of hepatic nitric oxide synthase produced similar degrees of insulin resistance and revealed a similar dynamic pattern of hormone action that began 3--4 min after, and continued for 9--10 min beyond, insulin action (50 mU/kg). HISS action accounted for 56.5 +/- 3.5% of insulin action at insulin doses from 5 to 100 mU/kg (fed). We also tested the hypothesis that HISS release is controlled by the feed/fast status. Feeding resulted in maximal HISS action, which decreased progressively with the duration of fasting. (+info)Nitric oxide-dependent in vitro secretion of amylase from innervated or chronically denervated parotid glands of the rat in response to isoprenaline and vasoactive intestinal peptide. (7/71)
The basal in vitro release of amylase was similar from rat parotid lobules of innervated and chronically denervated glands and was unaffected by the inhibitors used in this study. The secretion of amylase induced by isoprenaline or vasoactive intestinal peptide (VIP) was reduced by one-third to one-half from the lobules of the innervated glands and even more so from the lobules of the denervated glands by ODQ, an inhibitor of soluble guanyl cyclase which is activated by nitric oxide (NO) and catalyses the cGMP production. The use of N (omega)-propyl-L-arginine (N-PLA) revealed that the evoked secretion of amylase in the denervated glands depended on the activity of neuronal type NO synthase to synthesize NO. Since the denervated gland is virtually devoid of NO synthase-containing nerve fibres, the neuronal type NO synthase was most probably of a non-neuronal source. NO-dependent amylase secretion was agonist related, since amylase secretion evoked by bethanechol and neuropeptide Y was not reduced by ODQ or N-PLA. Hence, under physiological conditions, activation of beta-adrenoceptors (sympathetic activity) and VIP receptors (parasympathetic activity) is likely to cause secretion of parotid amylase partly through a NO/cGMP-dependent intracellular pathway involving the activity of neuronal type NO synthase, possibly of acinar origin. (+info)Heartbeat control in leeches. II. Fictive motor pattern. (8/71)
The rhythmic beating of the tube-like hearts in the medicinal leech is driven and coordinated by rhythmic activity in segmental heart motor neurons. The motor neurons are controlled by rhythmic inhibitory input from a network of heart interneurons that compose the heartbeat central pattern generator. In the preceding paper, we described the constriction pattern of the hearts in quiescent intact animals and showed that one heart constricts in a rear-to-front wave (peristaltic coordination mode), while the other heart constricts in near unison over its length (synchronous coordination mode) and that they regularly switch coordination modes. Here we analyze intersegmental and side-to-side-coordination of the fictive motor pattern for heartbeat in denervated nerve cords. We show that the intersegmental phase relations among heart motor neurons in both coordination modes are independent of heartbeat period. This finding enables us to combine data from different experiments to form a detailed analysis of the relative phases, duty cycle, and intraburst spike frequency of the bursts of the segmental heart motor neurons. The fictive motor pattern and the constriction pattern seen in intact leeches closely match in their intersegmental and side-to-side coordination, indicating that sensory feedback is not necessary for properly phased intersegmental coordination. Moreover, the regular switches in coordination mode of the fictive motor pattern mimic those seen in intact animals indicating that these switches likely arise by a central mechanism. (+info)
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Neural top-down control of physiology
"Autonomic Renal Denervation Ameliorates Experimental Glomerulonephritis". Journal of the American Society of Nephrology. 19 (7 ... Love, J. A.; Yi, E.; Smith, T. G. (2007). "Autonomic pathways regulating pancreatic exocrine secretion". Autonomic Neuroscience ... Edwards, A. V.; Jones, C. T. (1993). "Autonomic control of adrenal function". Journal of Anatomy. 183 (Pt 2): 291-307. PMC ... Nance, D. M.; Sanders, V. M. (2007). "Autonomic innervation and regulation of the immune system (1987-2007)". Brain, Behavior, ...
Familial amyloid polyneuropathy
... may show evidence of chronic denervation and reinnervation. Autonomic testing, including quantitative sweat testing, can reveal ... Occasionally, biopsy of skin, nerve, or muscle may be performed, which can show signs of denervation and amyloid deposition ... Sudomotor function through electrochemical skin conductance may provide a measure of subclinical autonomic involvement. The ... muscular weakness and autonomic dysfunction. In its terminal state, the kidneys and the heart are affected. FAP is ...
Familial amyloid neuropathy
July 2006). "Impact of liver transplantation on cardiac autonomic denervation in familial amyloid polyneuropathy". Medicine ( ... The aggregation of one precursor protein leads to peripheral neuropathy and/or autonomic nervous system dysfunction. These ... are a rare group of autosomal dominant diseases wherein the autonomic nervous system and/or other nerves are compromised by ...
Paroxysmal sympathetic hyperactivity
At the time, her episodes were termed 'diencephalic autonomic epilepsy'. It was believed that both her sympathetic and ... The future may hold non-pharmacologic solutions such as renal sympathetic denervation. Perkes, Iain; Baguley, Ian J.; Nott, ... doi:10.1007/s10286-012-0184-4. Singh, DK; Singh, N (September 2011). "Paroxysmal Autonomic Instability with Dystonia in a Child ... Blackman, James A.; Patrick, Peter D.; Buck, Marcia L.; Rust, Jr, Robert S. (2004). "Paroxysmal Autonomic Instability With ...
Nerve injury
Denervation changes recorded by EMG are the same as those seen with axonotmetic injury. There is a complete loss of motor, ... This type of nerve damage may cause paralysis of the motor, sensory, and autonomic, and is mainly seen in crush injury. If the ... Electromyography (EMG) performed 2 to 4 weeks later shows fibrillations and denervation potentials in musculature distal to the ... There is frequently greater involvement of motor than sensory function with autonomic function being retained. In ...
Diabetic cardiomyopathy
Therefore, the diabetic heart shows clear denervation as the pathology progresses. This denervation correlates with ... The autonomic innervations of the myocardium in diabetic cardiomyopathy are altered and contribute to myocardial dysfunction. ... While the heart can function without help from the nervous system, it is highly innervated with autonomic nerves, regulating ... Other causes of denervation are ischemia from microvascular disease and thus appear following the development of ...
Postural orthostatic tachycardia syndrome
A variety of autonomic tests are employed to exclude autonomic disorders that could underlie symptoms, while endocrine testing ... Another subtype, neuropathic POTS, is associated with denervation of sympathetic nerves in the lower limbs. In this subtype, it ... June 2021). "Long-COVID postural tachycardia syndrome: an American Autonomic Society statement". Clinical Autonomic Research. ... And other updates on recent autonomic research". Clinical Autonomic Research. 30 (1): 3-5. doi:10.1007/s10286-019-00661-5. PMID ...
Endoscopic thoracic sympathectomy
The autonomic nervous system is not anatomically exact and connections might exist which are unpredictably affected when the ... Goebel, F.-D.; Füessl, H.S. (1983). "Mönckeberg's sclerosis after sympathetic denervation in diabetic and non-diabetic subjects ... ETS patients are being studied using the autonomic failure protocol headed by David Goldstein, M.D. Ph.D., senior investigator ... Sympathectomy developed in the mid-19th century, when it was learned that the autonomic nervous system runs to almost every ...
Orthostatic hypotension
It is also present in many patients with Parkinson's disease or Lewy body dementias resulting from sympathetic denervation of ... This rarely leads to fainting unless the person has developed true autonomic failure or has an unrelated heart problem.[ ... The numerous possible causes for orthostatic hypotension include certain medications (e.g. alpha blockers), autonomic ... including autoimmune autonomic ganglionopathy, multiple system atrophy, and other forms of dysautonomia. It is also associated ...
Megavitamin-B6 syndrome
Examination does not typically show signs of a motor deficit, dysfunction of the autonomic nervous system or impairment of the ... Needle electromyography studies generally reveal no signs of denervation. Megavitamin-B6 syndrome is characterized mainly by ... and autonomic functions. The primary treatment for megavitamin-B6 syndrome is to stop taking supplemental vitamin B6. Physical ... central nervous system, although in severe cases motor and autonomic imparement can occur. When examined, patients typically ...
Medullipin
This hypotensive response depends on an intact renal medulla and is not altered by renal denervation or the inhibition of the ... renin-angiotensin system (RAS) or autonomic nervous function Gothberg, 1994 - Gothberg G. Physiology of the renomedullary ...
List of MeSH codes (E04)
... denervation MeSH E04.525.210.080 - autonomic denervation MeSH E04.525.210.080.600 - parasympathectomy MeSH E04.525.210.080. ... muscle denervation MeSH E04.525.210.550 - nerve block MeSH E04.525.210.560 - nerve crush MeSH E04.525.210.700 - rhizotomy MeSH ...
Fritz Köberle
Köberle and his group of collaborators were able to prove that they were caused also by an extensive denervation of the ... by extensively quantifying the number of neurons of the autonomic nervous system in the Auerbach's plexus, that: 1) they were ... characterizing it as a disease of the autonomic nervous system, which establishes itself during the acute phase and provokes ... long term and slowly installing denervation. Since the trypanosoma does not seem to damage neurons directly, Köberle and other ...
Regional Acceleratory Phenomenon
Bunch, W H; Deck, J D; Romer, J (1977-01-01). "The effect of denervation on bony overgrowth after below knee amputation in rats ... Duncan, Cp; Shim, Ss (1977-08-01). "J. Edouard Samson Address: the autonomic nerve supply of bone. An experimental study of the ... Klein, L.; Dawson, M. H.; Heiple, K. G. (1977). "Turnover of collagen in the adult rat after denervation". The Journal of Bone ... Obtunded or absent RAP often accompanies sensory denervation. In neuropathic soft tissue lesions, such as those in diabetics ...
Adie syndrome
Additionally, patients with Holmes-Adie Syndrome can also experience problems with autonomic control of the body. This second ... pilocarpine may constrict the tonic pupil due to cholinergic denervation supersensitivity. A normal pupil will not constrict ... and affects the pupil of the eye and the autonomic nervous system. It is named after the British neurologists William John Adie ... "Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie's Syndrome". Case Reports in Neurological Medicine ...
Ross' syndrome
Epidemiology Ross Syndrome is a progressive autonomic dysfunction that can occur in any age, ethnicity, or gender. The average ... Ross AT (November 1958). "Progressive selective sudomotor denervation; a case with coexisting Adie's syndrome". Neurology. 8 ( ... "Clinical presentation and autonomic profile in Ross syndrome". Journal of Neurology. 268 (10): 3852-3860. doi:10.1007/s00415- ... Ross syndrome is a non life-threatening benign condition but delay in diagnosis can result in slow progression of autonomic ...
Spinal shock
Autonomic dysreflexia is permanent, and occurs from Phase 4 onwards. It is characterized by unchecked sympathetic stimulation ... The reason reflexes return is the hypersensitivity of reflex muscles following denervation - more receptors for ... In spinal cord injuries above T6, neurogenic shock may occur, from the loss of autonomic innervation from the brain. ...
Minimaze procedure
The autonomic nerves (ganglionated plexi) that may cause AF may be eliminated as well. Subsequently, the left side of the chest ... "Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation". ... A concept gaining support is that paroxysmal AF is mediated in part by the autonomic nervous system and that the intrinsic ... Supporting this is the finding that targeting these autonomic sites improves the likelihood of successful elimination of AF by ...
Substance P
This, ultimately, leads to a condition known as denervation supersensitivity as the post-synaptic nerves will become ... and general autonomic discharge. The actions of aprepitant are said to be entirely central, thus requiring passage of the drug ...
Parkinson's disease
Alterations in the autonomic nervous system can lead to orthostatic hypotension (low blood pressure upon standing), oily skin, ... Iodine-123-meta-iodobenzylguanidine myocardial scintigraphy can help find denervation of the muscles around the heart, which ... Alternatively, multiple systems atrophy or MSA usually has early onset of autonomic dysfunction (such as orthostasis), and may ... Finally, after ten years most people with the disease have autonomic disturbances, sleep problems, mood alterations and ...
Facial feedback hypothesis
Soussignan, Robert (2002). "Duchenne smile, emotional experience, and autonomic reactivity: A test of the facial feedback ... Facial Feedback and Neural Activity within Central Circuitries of Emotion-New Insights from Botulinum Toxin-Induced Denervation ... "Effects of Nonverbal Dissimulation on Emotional Experience and Autonomic Arousal". Journal of Personality and Social Psychology ... Facial Feedback and Neural Activity within Central Circuitries of Emotion-New Insights from Botulinum Toxin-Induced Denervation ...
Ciliary ganglion
4) Denervation supersensitivity. Like any denervated muscle, the iris becomes supersensitive to its normal neurotransmitter (in ... Both of these muscles are involuntary since they are controlled by the parasympathetic division of the autonomic nervous system ... Autonomic ganglia of the head and neck, Parasympathetic ganglia, Ophthalmic nerve, Oculomotor nerve). ...
Histamine
... denervation supersensitivity, ischemic lesions and stress. It has also been suggested that histamine controls the mechanisms by ... Autonomic & Autacoid Pharmacology. 35 (4): 51-8. doi:10.1111/aap.12037. PMID 27028114. Andersen HH, Elberling J, Arendt-Nielsen ...
William Bayliss
They set out to determine which nerves were involved, but denervation did not block the response. In a flash of inspiration ... The Bayliss and Starling Society was founded in 1979 as a forum for scientists with research interests in central and autonomic ...
Neuromuscular junction
Examples of autonomic dysfunction caused by LEMS include erectile dysfunction in men, constipation, and, most commonly, dry ... By doing so, it induces a transient flaccid paralysis and chemical denervation localized to the striated muscle that it has ... This rare disease can be marked by a unique triad of symptoms: proximal muscle weakness, autonomic dysfunction, and areflexia. ...
Neuromodulation (medicine)
In 1973, Hosbuchi reported alleviating the denervation facial pain of anesthesia dolorosa through ongoing electrical ... the global pharmaceutical company GlaxoSmithKline announced an initiative in bioelectric medicine in which the autonomic ...
Urination
The muscles controlling micturition are controlled by the autonomic and somatic nervous systems. During the storage phase, the ... The hyperactive state in the former condition suggests the development of denervation hypersensitization even though the ... Physiologically, urination involves coordination between the central, autonomic, and somatic nervous systems. Brain centres ...
Chronaxie
Several studies have suggested that the function of denervation-induced myoD may be to prevent the muscle atrophy induced by ... the physiological factors responsible for this change being under the influence of the autonomic nervous system. This example ... 2007) Permanent denervation of rat Tibialis Anterior after bilateral sciatectomy: Determination of chronaxie by surface ... The increase in myoD levels after denervation is possibly related not only to activation and proliferation of the satellite ...
Epigenetics of neurodegenerative diseases
The main group of sensory neuron diseases are hereditary sensory and autonomic neuropathies (HSAN) such as HSAN I, HSAN II, and ... However, while the drug delayed the onset of ALS, it did not increase lifespan or prevent denervation. Human trials of valproic ... and motor neuron loss and denervation were halted. No human trials have been conducted. Myasthenia gravis is an autoimmune ... nourishment in early onset mouse SMA models resulted in improved motor function and survival and delays progressive denervation ...
Hyperhidrosis
Reisfeld, Rafael (2006). "Sympathectomy for hyperhidrosis: Should we place the clamps at T2-T3 or T3-T4?". Clinical Autonomic ... Some patients have experienced cardiac sympathetic denervation, which can result in a 10% decrease in heart rate both at rest ... In people with a history of spinal cord injuries Autonomic dysreflexia Orthostatic hypotension Posttraumatic syringomyelia ... Associated with peripheral neuropathies Familial dysautonomia (Riley-Day syndrome) Congenital autonomic dysfunction with ...
History of catecholamine research
I find that even after complete denervation, whether of three days' or ten months' duration, the plain muscle of the dilatator ... ISBN 0-387-05517-7. H. H. Dale (1934). "Nomenclature of fibres in the autonomic system and their effectsle". The Journal of ... Clinical Autonomic Research. 9 (3): 145-149. doi:10.1007/BF02281628. PMID 10454061. S2CID 20999106. Josef Donnerer, Fred ... the so-called myoneural junctions connected with the true sympathetic or thoracic-lumbar division of the autonomic nervous ...
The effect of cardiac autonomic denervation on T wave alternans following exercise - CAMS Oxford Institute
Cardiac autonomic activity contributes to the mechanism of the post-exercise peak in T wave amplitude. ... is related to changes in cardiac autonomic activity by comparing these changes in heart transplant subjects versus a control ... The effect of cardiac autonomic denervation on T wave alternans following exercise ... The effect of cardiac autonomic denervation on T wave alternans following exercise ...
Jan 15 2021 This Week in Cardiology
Calcium-Induced Autonomic Denervation Linked to Lower Post-op AF JACC published a super-interesting RCT looking at post-cardiac ... CaCl2 basically shuts down autonomic activity. The primary endpoint was postoperative AF (POAF) and POAF incidence was reduced ... Recall that both sympathetic and parasympathetic neural trafficking in the atrial autonomic neural network is processed and ...
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Diabetic Autonomic Neuropathy and Circadian Misalignment in Type 1 Diabetes | IntechOpen
Wheeler and Watkins identified vagal denervation of the heart as a feature of diabetic autonomic neuropathy that could be ... Diabetic autonomic neuropathy.. Diabetes Care. 26. 5. 1553. 1579. *25. Vinik. A. I.. Maser. R. E.. Ziegler. D.. 2011. Autonomic ... Autonomic neuroscience. 108. 1-2. 73 EOF. 8 EOF. *66. Lee. K. H.. Jang. H. J.. Kim. Y. H.. Lee. E. J.. Choe. Y. S.. Choi. Y.. ... Using suitable cardiovascular autonomic reflex tests to diagnose cardiac autonomic neuropathy taking into account that a) the ...
Renal Sympathetic Denervation - Current And Future Trends
Catheter-based renal sympathetic denervation therapy is an interesting and promising new therapeutic method that has the ... Renal sympathetic denervation may benefit arrhythmia treatment because autonomic tone influences chronotropy, dromotropy, the ... Is Renal Denervation Permanent?. Renal denervation is permanent. Medication for the high blood pressure may be discontinued. ... Is Renal Denervation Effective?. Renal denervation, a minimally invasive technique, is a potential new non-drug therapeutic ...
Frontiers | Autonomic Neuropathy in Diabetes Mellitus
The most studied and clinically important form of DAN is cardiovascular autonomic neuropathy (CAN) defined as the impairment of ... The most studied and clinically important form of DAN is cardiovascular autonomic neuropathy defined as the impairment of ... autonomic control of the cardiovascular system in patients with diabetes after exclusion of other causes. The reported ... autonomic control of the cardiovascular system in patients with diabetes after exclusion of other causes. The reported ...
Introduction to Autonomic Pharmacology | Basic & Clinical Pharmacology, 14e | AccessMedicine | McGraw Hill Medical
A pharmacologic supersensitivity related to denervation supersensitivity occurs in autonomic effector tissues after ... TABLE 6-21Major autonomic receptor types.. View Table,,Download (.pdf). TABLE 6-2 Major autonomic receptor types. Receptor Name ... TABLE 6-31234567Direct effects of autonomic nerve activity on some organ systems. Autonomic drug effects are similar but not ... TABLE 6-3 Direct effects of autonomic nerve activity on some organ systems. Autonomic drug effects are similar but not ...
Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension | Heart
Blood pressure and autonomic responses to electrical stimulation of the renal arterial nerves before and after ablation of the ... Renal sympathetic denervation-a review of applications in current practice. Intervent Cardiol Rev 2014;9:54-61. ... Renal sympathetic denervation as second-line therapy in mild resistant hypertension: a pilot study. Catheter Cardiovasc Interv ... Effect of renal denervation on left ventricular mass and function in patients with resistant hypertension: data from a multi- ...
Fourth in a series on diabetes and the heart: Diabetic cardiovascular autonomic neuropathy - an underestimated enemy
In patients with advanced autonomic denervation and orthostatic hypotension the lethality rates increase to 16-35% at 5 years [ ... Hyperglycemia leads to sympathetic denervation, changes in myocardial autonomic neurotransmitter levels, altered expression of ... HR becomes fixed and unresponsive as a result of complete heart denervation, indicating almost complete cardiac denervation and ... Abbreviations: CAN: cardiac autonomic neuropathy; HR: heart rate.. Prognosis. DCAN is a complication that confers a higher ...
Cardiovascular, autonomic, and plasma catecholamine responses in unilateral and bilateral carotid artery stenosis | Journal of...
... with central or peripheral sympathetic denervation.9 This, however, was unlikely as responses to pressor stimuli (that reflect ... 1999) Investigation of autonomic disorders. in Autonomic failure. A textbook of clinical disorders of the autonomic nervous ... Physiological tests of autonomic function were performed using previously described techniques.9 The tests were performed in ... Cardiovascular autonomic testing and assessment of postural hypotension and factors enhancing it may be of clinical relevance ...
Brain mineralocorticoid receptors and centrally regulated functions
Impact of cardiac sympathetic denervation on IH-induced ischemic cardiomyopathy aggravation
Autonomic dysfunction in moderate acute lung injury induced by paraquat. Source: Eur Respir J 2006; 28: Suppl. 50, 821s. Year: ... Impact of cardiac sympathetic denervation on IH-induced ischemic cardiomyopathy aggravation. M. Détrait (Grenoble, France), J. ... Impaired cardiac autonomic control relates to disease severity in pulmonary hypertension. Source: Eur Respir J 2009; 34: 895- ... Assessment of cardiac autonomic function during deep breathing test in acute myocardial infarction. Source: Annual Congress ...
Diabetes complications | 0026 | ECE2011 | 13th European Congress of Endocrinology | Endocrine Abstracts
Autonomic neuropathy with subsequent renal denervation, combined with damaged erythropoetin producing fibroblasts in renal ... Diabetic patients with autonomic neuropathy do need erythropoetin therapy at the early stagies of renal failure. Giannakaki S , ... Proliferative retonopathy, autonomic neuropathy, microalbuminuria, and moderate renal failure, suggesting that, factors o... ...
DeCS
94; DENERVATION, AUTONOMIC was see SYMPATHECTOMY 1989-93. Online Note:. use SYMPATHECTOMY to search DENERVATION, AUTONOMIC 1989 ... Autonomic Denervation - Preferred Concept UI. M0026849. Scope note. The removal or interruption of some part of the autonomic ... The removal or interruption of some part of the autonomic nervous system for therapeutic or research purposes.. ... Autonomic Denervations. Denervation, Autonomic. Denervations, Autonomic. Tree number(s):. E04.525.210.105. RDF Unique ...
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Autonomic testing revealed denervation hypersensitivity in norepinephrine (NE) intravenous infusion test and 0.125% pilocarpine ... These findings indicated dysfunction of postganglionic autonomic nerves. Autoimmune autonomic ganglionopathy (AAG) was ... Acute-onset autoimmune autonomic ganglionopathy remarkably effective in intravenous high-dose immunoglobulin therapy. Keishu ... key words: autoimmune autonomic ganglionopathy, intravenous high-dose immuneoglobulin therapy, acute-onset ...
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SGLT2-I-users had alterations of the autonomic nervous system, with a higher rate of VVS recurrence at 1 year of follow-up. The ... indexes of cardiac denervation predicted the VVS recurrence, while the SGLT2-I reduced the risk of VVS recurrence ... SGLT2-inhibitors reduce the cardiac autonomic neuropathy dysfunction and vaso-vagal syncope recurrence in patients with type 2 ...
Type 2 diabetes mellitus and risk of community-acquired pneumonia: a systematic review and meta-analysis of observational...
Autonomic Neuropathy: Background, Pathophysiology, Inherited Autonomic Neuropathies
Autonomic neuropathies can be hereditary or acquired in nature. ... Autonomic neuropathies are a collection of syndromes and ... diseases affecting the autonomic neurons, either parasympathetic or sympathetic, or both. ... 36] Autonomic denervation may be related to antineuronal antibodies; the neuropathy does not appear to respond to a gluten-free ... Acquired Autonomic Neuropathies. The acquired autonomic neuropathies are much more prevalent than the inherited ones. Here, we ...
Kalyanam Shivkumar - UCLA Graduate Programs in Bioscience (GPB)
Cardiac sympathetic denervation and mental health.. Autonomic neuroscience : basic & clinical, 2021.. *Fontaine AK, Futia GL, ... Cardiovascular autonomic reflex function after bilateral cardiac sympathetic denervation for ventricular arrhythmias.. Heart ... Renal denervation as adjunctive therapy to cardiac sympathetic denervation for ablation refractory ventricular tachycardia.. ... Autonomic neuroscience : basic & clinical, 2017.. *Hamon D, Abehsira G, Gu K, Liu A, Blaye-Felice Sadron M, Billet S, Kambur T ...
Kalyanam Shivkumar, Ph.D. - UCLA Brain Research Institute (BRI)
Cardiac sympathetic denervation and mental health.. Autonomic neuroscience : basic & clinical, 2021.. *Fontaine AK, Futia GL, ... Cardiovascular autonomic reflex function after bilateral cardiac sympathetic denervation for ventricular arrhythmias.. Heart ... Renal denervation as adjunctive therapy to cardiac sympathetic denervation for ablation refractory ventricular tachycardia.. ... Autonomic neuroscience : basic & clinical, 2017.. *Hamon D, Abehsira G, Gu K, Liu A, Blaye-Felice Sadron M, Billet S, Kambur T ...
Autonomic Dysreflexia in Spinal Cord Injury: Practice Essentials, Pathophysiology, Causes of Autonomic Dysreflexia
Autonomic dysreflexia is a potentially dangerous clinical syndrome that develops in individuals with spinal cord injury, ... Other successful methods trialed to help prevent autonomic dysreflexia are sacral denervation and sphincterotomy. ... Causes of Autonomic Dysreflexia. Episodes of autonomic dysreflexia can be triggered by many potential causes. [14] Essentially ... Prevention of Autonomic Dysreflexia. Patients who have previously experienced autonomic dysreflexia may be able to prevent the ...
The value of caval division in the maze procedure with valve surgery<...
The explanation of this observation is not clear, but denervation of the cardiac autonomic nervous system or the existence of ... The explanation of this observation is not clear, but denervation of the cardiac autonomic nervous system or the existence of ... The explanation of this observation is not clear, but denervation of the cardiac autonomic nervous system or the existence of ... The explanation of this observation is not clear, but denervation of the cardiac autonomic nervous system or the existence of ...
NervousDysfunctionFeatures of autonomicVagal denervationNervesCardiovascular autonomic neuropathyControl of the cardiovascular systemNeuronsRegulationMyocardialSensory2019InvolvementCarotidIschemicApneaDiabeticNeuropathyNeurosciencePostural hypotensionArterial hypertensionDisturbancesClinicalPathophysiologyAchieve renalHypertensionLesionsNeuropathiesPatientsHypertensiveArrhythmiasSymptomsBilateralImpairmentModulationPreferableAxonCatheterRatsFunctionOnsetHeart
Nervous22
- Mutant transthyretin produced in the liver accumulates as amyloid deposits in the peripheral nervous system and autonomic nervous system. (medscape.com)
- These types differ in their presentation, the portions of the autonomic nervous system affected, their associated genes, and inheritance pattern. (medscape.com)
- found the vascular responses to the Valsalva manoeuvre and sustained handgrip useful in providing an objective assessment of the integrity of the autonomic nervous system in diabetes [ 15 ]. (intechopen.com)
- Ewing himself later developed the cardiovascular autonomic function test battery still in use to provide an objective diagnosis of autonomic nervous system involvement [ 16 ]. (intechopen.com)
- To date, the role of the renal sympathetic nervous system in controlling blood pressure and other autonomic processes was unknown. (washingtonindependent.com)
- Functionally, the nervous system can be divided into two major subdivisions: autonomic and somatic. (mhmedical.com)
- The autonomic nervous system (ANS) is largely independent (autonomous) in that its activities are not under direct conscious control. (mhmedical.com)
- Moreover a substantial body of evidence from non-randomised smaller trials does suggest that renal denervation may have an important role in the management of hypertension and other disease states characterised by overactivation of the sympathetic nervous system. (bmj.com)
- It is associated with an increased cardiovascular morbidity and mortality, caused by a dysregulation of the autonomic nervous system. (escardio.org)
- In DCAN there are disturbances in the balance of the autonomic nervous system (ANS) that result in loss of heart rate variability (HRV) and abnormalities in microvascular dynamics [3, 7, 8]. (escardio.org)
- The removal or interruption of some part of the autonomic nervous system for therapeutic or research purposes. (bvsalud.org)
- Dr. Shivkumar's research work relates to mechanisms of cardiac arrhythmias in humans especially the role of the autonomic nervous system and his research work transcends the perspective of a single organ and has implications for neurovisceral sciences in general. (ucla.edu)
- The explanation of this observation is not clear, but denervation of the cardiac autonomic nervous system or the existence of paroxysmal AF originating from the SVC could be involved. (fujita-hu.ac.jp)
- Other important autonomic nervous system involvements include the nerves innervating the capillaries of legs. (who.int)
- Before we explore this issue, lets first learn a bit about the autonomic nervous system and about the cardiac systems place within it. (parkinsonsdaily.com)
- From there, the autonomic nervous system sends signals to the heart to control heart rate and cardiac output. (parkinsonsdaily.com)
- Both the sympathetic and parasympathetic nervous systems carry out different roles in the regulation of atrial electrophysiological properties, and the concept of autonomic nervous imbalance has been proposed to explain the atrial electrical instability and AF occurrence in the aspect of cardiac ANS. (parkinsonsdaily.com)
- Denervation of the intrinsic cardiac autonomic nervous system may be the preferable target of catheter ablation of AF. (mirnamimics.com)
- Molecular imaging techniques have been developed for global and regional assessment of presynaptic and postsynaptic targets of the cardiac autonomic nervous system. (isoinhealth.com)
- The autonomic nervous system (ANS) is the thoroughfare responsible for filtering, processing, reacting to and recovering from stress. (endo-education.com)
- The central autonomic nervous system is a functional and structural network that integrates cognitive and affective processing with peripheral end organ activity. (endo-education.com)
- This type of denervation is used often in experimental studies on neuronal physiology and neuronal death or survival, toward an understanding of nervous system disease. (uams.edu)
Dysfunction11
- therefore, autonomic dysfunction may manifest with numerous clinical phenotypes and various laboratory and neurophysiologic abnormalities. (medscape.com)
- These findings indicated dysfunction of postganglionic autonomic nerves. (neurology-jp.org)
- The Norfolk questionnaire evaluated QoL and the Compound Autonomic Dysfunction Test assessed autonomic involvement. (bvsalud.org)
- We applied questionnaires and clinical scales, sensory thresholds, and sudomotor testing to assess severity of motor and non-motor involvement and sensory and autonomic dysfunction. (bvsalud.org)
- According to numerous neuroimaging studies, autonomic dysfunction is a common non-motor symptom of PD. (parkinsonsdaily.com)
- Studies have presented that cardiac noradrenergic denervation is a widespread phenomenon in PD regardless of clinical ANS dysfunction. (parkinsonsdaily.com)
- Putting these findings together, cardiac sympathetic denervation and ANS dysfunction are plausible mechanisms of the increased risk of AF in patients with PD. (parkinsonsdaily.com)
- Conclusions: Our results demonstrate significant sleep fragmentation with sympathetic hyperactivity after MI and that RDN prevents autonomic dysfunction and disordered sleep. (nycu.edu.tw)
- Work of our group and others have indicated that the establishment of arterial hypertension is accompanied by autonomic dysfunction and hyperactivity of the Renin Angiotensin System (RAS) in the brain tissue. (fapesp.br)
- General medical symptoms and body organ manifestations could also occur as a primary consequence from the autonomic dysfunction connected with Parkinsons disease. (stemcellresearchformichigan.com)
- Patients present with various degrees of parkinsonism, autonomic failure, cerebellar dysfunction, and pyramidal signs that are poorly responsive to levodopa or dopamine agonists. (medscape.com)
Features of autonomic3
- Signs of denervation of iris and reduced intraocular pressure are permanent features of autonomic involvement in the eye. (who.int)
- With no features of autonomic insufficiency. (medpresspublications.com)
- Neurological examination was consistent with idiopathic PD, with no features of autonomic insufficiency. (medpresspublications.com)
Vagal denervation4
- Wheeler and Watkins identified vagal denervation of the heart as a feature of diabetic autonomic neuropathy that could be evaluated by monitoring beat-to-beat variation in heart rate [ 14 ]. (intechopen.com)
- Three years ago, we demonstrated for the first time the advantage of vagal denervation in patients with paroxysmal AF who underwent ablation and these observations are still a milestone today for understanding the pathophysiology and treatment of AF. (af-ablation.org)
- The CPVA consists of large circumferential lines of injury performed point by point, so as to allow the disconnection of all pulmonary veins (PV), vagal denervation and the non-inducibility of both AF and atrial tachycardia (AT) at the end of the procedure. (af-ablation.org)
- Relentless exposure to stress, paired with high stress reactivity, may promote systemic vagal denervation and reduced vagal tone. (endo-education.com)
Nerves6
- Rarely, a mutation in the gelsolin gene, which produces a protein important in cytoskeletal actin function, may also lead to amyloid deposition in autonomic nerves. (medscape.com)
- Renal denervation goes back to 1953 when splanchnicectomy (surgical removal of renal nerves) was mentioned as a therapy option in individuals with severe primary hypertension. (washingtonindependent.com)
- Remarkably, some evidence indicates that autonomic nerves can also influence cancer development and progression. (mhmedical.com)
- OBJECTIVE: To assess the cutaneous neural distribution of p-α-Syn deposits and its correlation with clinical data and with morphology and function of cutaneous sensory and autonomic nerves in early Parkinson's disease (PD) and multiple system atrophy-parkinson type (MSA-p). (bvsalud.org)
- Leprosy has been shown to affect almost all systems of human body and abnormalities in functions of autonomic nerves innervating various parts have been observed in several studies. (who.int)
- Abnormal testicular pain sensation and diminished nocturnal penile tumiscence provide evidence of afflication of autonomic nerves of male genital system. (who.int)
Cardiovascular autonomic neuropathy4
- The most studied and clinically important form of DAN is cardiovascular autonomic neuropathy defined as the impairment of autonomic control of the cardiovascular system in patients with diabetes after exclusion of other causes. (frontiersin.org)
- The most common and studied manifestation of DAN is cardiovascular autonomic neuropathy (CAN), owing to its life-threatening complications (arrhythmias, silent myocardial ischemia, and sudden death) and to its relation with other microangiopathic comorbidities. (frontiersin.org)
- Diabetic cardiovascular autonomic neuropathy is a frequent complication in diabetic patients, often underdiagnosed. (escardio.org)
- Diabetic cardiovascular autonomic neuropathy (DCAN) was first described in 1975 by Low et al, after determining that diabetic neuropathy also compromised autonomic control of the cardiovascular system, as evidenced by orthostatic hypotension (OH) and abnormal autonomic responses to different stimuli [1]. (escardio.org)
Control of the cardiovascular system1
- CAN is defined as the impairment of autonomic control of the cardiovascular system ( 5 ). (frontiersin.org)
Neurons2
- Autonomic neuropathies are a collection of syndromes and diseases affecting the autonomic neurons, either parasympathetic or sympathetic, or both. (medscape.com)
- We also demonstrated that SAD reduced the tone of pre-autonomic neurons of the Paraventricular Nucleus of the Hypothalamus (PVN), suggesting the importance of peripheral activity induced by exercise and carried by baroreceptors and peripheral chemoreceptors in reducing sympathetic activity. (fapesp.br)
Regulation2
- MR is also involved in control of autonomic outflow and volume regulation. (nih.gov)
- Using a porcine model of ischemic heart disease, our team investigates cardiac autonomic regulation and remodeling, employing in-vitro protein analysis and whole animal PET imaging to identify sympathetic denervation and subsequent neuronal sprouting. (ubmd.com)
Myocardial2
- DCAN is one of the least understood of all complications of DM and has been defined as the presence of abnormal myocardial performance secondary to dysregulation of autonomic cardiovascular control in the absence of other causes [3, 7]. (escardio.org)
- Hyperglycemia leads to sympathetic denervation, changes in myocardial autonomic neurotransmitter levels, altered expression of neuropeptides and their signaling pathways, together with an altered beta-receptor density. (escardio.org)
Sensory3
- Familial amyloid polyneuropathy, the hereditary sensory autonomic neuropathies, Fabry disease, and the porphyrias are genetic diseases in which autonomic neuropathy is a common feature. (medscape.com)
- Currently, 5 types of hereditary sensory autonomic neuropathy (HSAN) have been defined (see Table 1). (medscape.com)
- Both the autonomic and the somatic systems have important afferent (sensory) inputs that provide information regarding the internal and external environments and modify motor output through reflex arcs of varying complexity. (mhmedical.com)
20191
- He was elected as an honorary Fellow of the Royal College of Physicians (London) in 2016 & President of the ISAN (International Society of Autonomic Neuroscience) in 2019. (ucla.edu)
Involvement3
- In some forms, the degree and type of autonomic system involvement varies extensively. (medscape.com)
- 2003). This statement will focus on three major sub-groups: (1) medical comorbidity, arising independently of the underlying disease, (2) clinical symptoms arising as a result of disease-associated autonomic denervation, and (3) side effects of the Parkinsons disease medication itself, which may necessitate the involvement of other specialists. (stemcellresearchformichigan.com)
- The degeneration of medullary autonomic nuclei which regulate baroreflex responses for accumulation of material (i.e. hyperphosphorylate -tau protein or fibrillar amyloid-beta) [9] allows to think of a progressive involvement of cognitive, motor and autonomic activities [8]. (scirp.org)
Carotid2
- OBJECTIVE To determine impairment of baroreceptor afferent activity, which may affect cardiovascular autonomic function in patients with unilateral and bilateral carotid artery stenosis. (bmj.com)
- Carotid body afferent nerve responses to hypoxia and hyperoxia-induced respiratory depression were pronounced in PM-challenged CREBA133 mice, and denervation of the carotid bodies significantly reduced PM-mediated cardiac arrhythmias. (cdc.gov)
Ischemic1
- Possible etiologies including sympathetic denervation, ischemic injury to the sinus node, and graft ischemia. (openanesthesia.org)
Apnea1
- RDN may then reduce sleep apnea and sleep-related sudden cardiac death after MI by restoring autonomic homeostasis. (nycu.edu.tw)
Diabetic5
- Diabetic autonomic neuropathy, particularly cardiac autonomic neuropathy, is considered an important potential factor involved in the disruption of circadian cardiovascular rhythms [ 10 ]. (intechopen.com)
- The review summarises the battery of non-invasive autonomic function tests available for diabetic autonomic neuropathy diagnosis as well as cross-sectional and follow-up studies supporting their importance in risk stratification for diabetic micro-vascular complications and cardiovascular morbidity/mortality. (intechopen.com)
- In 1973, the British Medical Journal and the Lancet published three articles on diabetic autonomic neuropathy [ 13 - 15 ], which would then be followed over the years by an unbroken series of studies and publications. (intechopen.com)
- Diabetic autonomic neuropathy (DAN) is a serious and common complication of diabetes, often overlooked and misdiagnosed. (frontiersin.org)
- Diabetic autonomic neuropathy (DAN) is included in the first group. (frontiersin.org)
Neuropathy1
- Liver transplantation, currently the most effective treatment for FAP, may slow the development of autonomic neuropathy, but not in all cases. (medscape.com)
Neuroscience1
- Autonomic neuroscience : basic & clinical, 2022. (ucla.edu)
Postural hypotension1
- Cardiovascular autonomic testing and assessment of postural hypotension and factors enhancing it may be of clinical relevance in such patients, especially as the symptoms of postural hypotension overlap with those due to thromboembolism. (bmj.com)
Arterial hypertension1
- Bolotov P.A., Semitko S.P., Klimov V.P., Vertkina N.V. Transcatheter sympathetic renal denervation for resistant arterial hypertension: the current state. (omnidoctor.ru)
Disturbances2
- In the cardiac autonomic functions, rhythm disturbances have been documented by several investigators. (who.int)
- The greatest cause of general medical problems in PD is usually PD itself, mostly due to the functional disturbances that arise from your autonomic denervation which affects nearly all the organs (Goetz et al. (stemcellresearchformichigan.com)
Clinical3
- The most significant clinical experience has been gained with the Symplicity (Medtronic Inc., CA, USA) catheter, which is designed to transport radiofrequency radiation through the renal artery wall to achieve renal denervation. (washingtonindependent.com)
- Although initial clinical trials of renal denervation in patients with resistant hypertension demonstrated encouraging office blood pressure reduction, a large randomised control trial (Symplicity HTN-3) with a sham-control limb, failed to meet its primary efficacy end point. (bmj.com)
- The Joint UK Societies does not recommend the use of renal denervation for treatment of resistant hypertension in routine clinical practice but remains committed to supporting research activity in this field. (bmj.com)
Pathophysiology1
- The pathophysiology of autonomic neuropathies is variable and depends upon the underlying medical conditions. (medscape.com)
Achieve renal1
- Recently there has been considerable interest in the use of endoluminal renal denervation as an interventional technique to achieve renal nerve ablation and lower blood pressure. (bmj.com)
Hypertension2
- Renal sympathetic denervation is a minimally invasive treatment used to treat resistant hypertension. (washingtonindependent.com)
- In animal investigations, invasive renal sympathetic denervation was shown to diminish afferent and efferent sympathetic activity, essential in developing hypertension, heart failure, and renal disease. (washingtonindependent.com)
Lesions1
- Pelvic surgical procedures can generate urinary or sexual dysfunctions because of denervation lesions. (academie-medecine.fr)
Neuropathies4
- Autonomic neuropathies can be hereditary or acquired in nature. (medscape.com)
- We have chosen to classify the autonomic neuropathies into hereditary and acquired. (medscape.com)
- The acquired autonomic neuropathies may then be subsequently subdivided into primary or secondary. (medscape.com)
- All forms of inherited autonomic neuropathies are rare. (medscape.com)
Patients5
- Misalignment of circadian rhythms has been evidenced in patients with type 1 diabetes and there is a close relationship between alterations in neuroendocrine sleep architecture, circadian clock oscillations, glucose metabolism, autonomic function, and diurnal profiles of blood pressure and heart rate [ 1 - 5 ]. (intechopen.com)
- Catheter-based renal sympathetic denervation therapy is an exciting and promising new therapeutic method that has the potential to change the present treatment paradigm in patients. (washingtonindependent.com)
- In patients with advanced autonomic denervation and orthostatic hypotension the lethality rates increase to 16-35% at 5 years [2, 3, 7]. (escardio.org)
- 6-8 There have been no detailed studies using physiological testing as utilised in patients with autonomic failure, to determine responses in those with clearly defined unilateral and bilateral CAS. (bmj.com)
- Over the past two years, pioneering groups have confirmed our previous results, even in patients with permanent AF using a gradual approach, which includes the sequential addition of additional targets of ablation through repeated ablative procedures, so as to limit or modify the anatomical substrates, electrophysiological and / or autonomic (15). (af-ablation.org)
Hypertensive1
- In previous work, we also demonstrated that low to moderate intensity aerobic training (T) in spontaneously hypertensive rats (SHR) reduces RAS activity in autonomic areas, increases baroreceptor reflex gain, reduces peripheral sympathetic activity, PA and heart rate (HR) and that these effects were blocked by sinoaortic denervation (SAD, Ceroni et al, 2009). (fapesp.br)
Arrhythmias1
- CREBA133 mice, which display aberrant cardiac physiology and anatomy reminiscent of human CHF, displayed evidence of basal autonomic aberrancies (compared with wild-type mice) with PM exposure via aspiration, producing significantly reduced heart rate variability, respiratory dysynchrony, and increased ventricular arrhythmias. (cdc.gov)
Symptoms1
- Although a patient may present with symptoms related to a single portion of the autonomic system, the physician must be vigilant for other affected parts of the autonomic system. (medscape.com)
Bilateral1
- Diuresis and urinary electrolyte excretion are increased after the MR antagonist, but this effect is abolished after bilateral denervation of the kidney. (nih.gov)
Impairment1
- The central control of breathing and the sympathetic bronchial innervation can also be jeopardized by the autonomic impairment. (frontiersin.org)
Modulation1
- Good glycemic control, control of cardiovascular disease (CVD) risk factors and pharmacologic modulation of oxidative stress and autonomic dysregulation reduce its progression and the increased risk of death from this condition [3]. (escardio.org)
Preferable1
- The renal denervation technique was carried out in the catheterization lab using either radiofrequency energy, ultrasound energy, or neurotoxic chemicals (alcohol), with no clear indication that one way is preferable. (washingtonindependent.com)
Axon1
- Autonomic testing revealed denervation hypersensitivity in norepinephrine (NE) intravenous infusion test and 0.125% pilocarpine instillation test, low NE in the serum, and decreased amount of sweating in quantitative sudomotor axon reflex test. (neurology-jp.org)
Catheter1
- A brief study found that renal denervation with the Symplicity catheter had a great safety profile and led to a significant and sustained office BP decrease of 27/17 mmHg after 12 months. (washingtonindependent.com)
Rats1
- We aimed to evaluate the effects of renal denervation (RDN) on cardiac autonomic activity and disordered sleep patterns in rats with MI. (nycu.edu.tw)
Function2
- Sympathetic denervation begins at the following stage, by affecting the heart from the apex toward the base, gradually impairing ventricle function and resulting in cardiomyopathy ( 12 ). (frontiersin.org)
- An impairement of cardiac autonomic function reflects the severity of the cardiac disease and seems to increase the risk of death in these pts [2]. (isoinhealth.com)
Onset1
- HSAN III (Riley-Day syndrome) is autosomal recessive in Ashkenazi Jews, with early childhood onset of autonomic crises. (medscape.com)
Heart3
- This study tested the hypothesis that the post-exercise peak in T wave amplitude (TWA) is related to changes in cardiac autonomic activity by comparing these changes in heart transplant subjects versus a control group of kidney transplant subjects. (ox.ac.uk)
- Cardiac autonomic activity was measured by analyzing the power spectrum of heart rate variability. (nycu.edu.tw)
- It has been historically understood that indirect agents such as ephedrine or those that work via a vagolytic mechanism (glycopyrrolate, atropine) will not be effective in increasing heart rate, due to total autonomic denervation . (openanesthesia.org)