Autoimmune lymphoproliferative syndrome (ALPS) is characterized by nonmalignant lymphadenopathy, splenomegaly, and autoimmune cytopenias. In 1995, defective lymphocyte apoptosis secondary to mutations in the FAS gene was identified as a molecular basis for ALPS.

The purpose of the protocol is to allow for patients, and relatives of patients, who may have the newly described autoimmune lymphoproliferative syndrome, to be evaluated at the NIH Clinical Center. This evaluation will include blood and relevant tissue studies along with long-term clinical evaluations to define the biology, inheritance,clinical spectrum, and natural history of this syndrome. The aim of the research is to understand mechanisms involved in the development of expanded numbers of what is typically a rare population of immune cells (CD4-8-/TCRalpha/beta+ T cells, otherwise referred to as double negative T cells), and how these relate to the development of expanded numbers of immune cells and autoimmune (self against self) responses in patients with ALPS.. In some cases, we may proivide treatment related to ALPS. These treatments are consistent with standard medical practice.. Participants with ALPS will be invited to visit the NIH once a year or more frequently when clinically ...

This study will evaluate the safety and effectiveness of an antibiotic called Fansidar on autoimmune lymphoproliferative syndrome (ALPS). Patients with ALPS have enlarged lymph glands, spleen and/or liver, abnormal blood cell counts and overactive immune function. Current treatments are aimed at suppressing the immune system and improving symptoms, such as anemia (low red blood cell count) and low white blood cell and platelet counts. These treatments, however, are only partially effective and may have complications. Fansidar is a combination of two drugs, sulfadoxine and pyrimethamine, that is used to treat or prevent parasitic infections such as malaria. Recently a child with ALPS who was treated with Fansidar for a different illness had a marked shrinkage of the lymph organs. This study will examine whether Fansidar can shrink the lymph glands or spleen in patients with ALPS.. Patients with ALPS between the ages of 4 and 70 years who have had lymph gland enlargement for at least 1 year and ...

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; ALPS description, symptoms and related genes. Get the complete information in our medical search engine for p

Langan RC, Gill F, Raiji MT, Mullinax JE, Pittaluga S, Pandalai P, Davis J, Perkins K, Avital I, Rudloff U. Autoimmune pancreatitis in the autoimmune lymphoproliferative syndrome (ALPS): a sheep in wolves clothing? Pancreas. 2013 Mar; 42(2):363-6 ...

Teachey DT, Manno CS, Axsom KM, et al: Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS). Blood 2005;105:2443-2448. Bader-Meunier B, Rieux-Laucat F, Croisille L, et al: Dyserythropoiesis associated with a fasdeficient condition in childhood. Br J Haematol 2000;108:300-304. Pensati L, Costanzo A, Ianni A, et al: Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis. Gastroenterology 1997;113: 1384-1389. Cell 1997;89:1067-1076. Stanger B, Leder P, Lee T, Kim E, Seed B: RIP: A novel protein containing a death domain that interacts with fas/APO-1(CD95) in yeast and causes cell death. Cell 1995;81:513-523. Chu K, Niu X, Williams LT: A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci USA 1995;92:11894-11898. Barnhart BC, Alappat EC, Peter ME: The CD95 type I/type II model. Semin Immunol 2003;15: 185-193. Siegel RM, Muppidi JR, Sarker M, ...

Treatment is most commonly directed at autoimmune disease and may be needed to treat bulky lymphoproliferation. First line therapies include corticosteroids (very active but toxic with chronic use), and IVIgG, which are not as effective as in other immune cytopenia syndromes. Second line therapies include: mycophenolate mofetil (cellcept)[15] which inactivates inosine monophosphate, most studied in clinical trials with responses varying (relapse, resolution, partial response). It does not affect lymphoproliferation or reduce DNTs, with no drug-drug interactions. This treatment is commonly used agent in patients who require chronic treatment based on tolerance and efficacy. It may cause hypogammaglobulinemia (transient) requiring IVIgG replacement. Sirolimus (rapamycin, rapamune) which is a mTOR (mammalian target of rapamycin) inhibitor[16] can be active in most patients and can in some cases lead to complete or near-complete resolution of autoimmune disease (,90%)[17][18] With this treatment ...

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Covered on Genetics Home Reference: autoimmune lymphoproliferative syndromebreast cancerFrom NCBI Gene: Caspase-8 deficiencyHepatocellular carcinomaFamilial cancer of breastLung cancerFrom UniProt: Caspase-8 deficiency (CASP8D): Disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs). It leads to defects in activation of T-lymphocytes, B-lymphocytes, and natural killer cells leading to immunodeficiency characterized by recurrent sinopulmonary and herpes simplex virus infections and poor responses to immunization. [MIM:607271] From NCBI Gene: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of ...

RAS-associated autoimmune leukoproliferative disorder (RALD) is a rare genetic disorder of the immune system. RALD is characterized by lymphadenopathy, splenomegaly, autoimmunity, and elevation in granulocytes and monocytes. It shares many features with autoimmune lymphoproliferative syndrome and is caused by somatic mutations in NRAS or KRAS. This was first described by investigators João Oliveira and Michael Lenardo from the National Institutes of Health. Clinically, RALD is characterized by splenomegaly, a relatively mild degree of peripheral lymphadenopathy, and autoimmunity. The autoimmune phenotype can present in childhood or adulthood and primarily includes autoimmune hemolytic anemia, ITP, and neutropenia. Some patients have a history of recurrent respiratory tract infections. It is unclear if increased risk for malignancy is part of RALD. Importantly, however, the clinical and laboratory phenotype resembles juvenile myelomonocytic leukemia. The high fatality rate of this childhood ...

We report the case of a young woman who developed, 3 years after stopping Rituximab (RTX) prescribed for immune thrombocytopenia (ITP), a severe immunodeficiency leading to fatal pulmonary Epstein–Barr virus-positive diffuse large B-cell lymphoma. Genetic analysis led us to identify four missense mutations known to affect immune-deficiency–associated genes (FAS-ligand (|i|FASL|/i|) gene (p.G167R); perforin-1 (|i|PRF1|/i| (p.R55C) gene; the Bloom syndrome RecQ-Like helicase (|i|BLM|/i|) gene and the Moesin (|i|MSN|/i|) (p.A122T) gene). The heterozygous mutation in the |i|FASL|/i| gene, not present in the Genome Aggregation Database or ClinVar database, could suggest atypical Autoimmune LymphoProliferative Syndrome and its role in this patient’s immunodepression is discussed. This observation strengthens the role of |i|FASL|/i| gene mutation in severe clinical phenotypes of primary immune deficiency and raises new questions about the genetic background of ITP occurring in young people

A fundamental biological question that remains largely unresolved concerns the mechanism by which binding of ligands to receptors on the cell surface causes transmission of a signal through the plasma membrane. One appealing explanation has been that ligand binding brings receptors together into multimeric complexes. Three reports describe cases in which the opposite approach is taken, and the receptors are bound and lie in wait for the ligand. Siegel et al. and Chan et al. have examined how the Fas and tumor necrosis factor (TNF) receptors signal. They define a protein interaction domain in these receptors that mediates assembly of the receptors into complexes in the absence of ligand. Such association is shown to be necessary for ligand binding and subsequent signaling. The results also explain how abnormal forms of Fas can dominantly prevent Fas-induced signaling in the human disease known as autoimmune lymphoproliferative syndrome. When bound to their cognate receptors, interferons (IFNs) ...

Although ALPS is frequently caused by mutations in known genes, such as FAS, FASLG or CASP10, in 20-30% of cases the defect is still unknown. It is highly likely that defects in or overexpression of regulators of these genes such as miR-146a22 could result in an ALPS-like phenotype and account for a not yet defined percentage of ALPS-U cases. In the present study we identified an IL12RB1 mutation and the IL12 signaling pathway as such an alternative cause of an ALPS-like phenotype through regulation of FasL expression. Previously it was shown that activation of T and NK cells by IL12 results in upregulation of FasL.23-26,28,42 For instance, Yu et al. showed that dendritic cell-derived IL12 is involved in upregulation of FasL on NK cells leading to cell death.25 Moreover, in the absence of antigen, IL12 induces apoptosis of T cells via upregulation of FasL which can be blocked by anti-FasL antibodies.26 In line with this, we found that primary human T cells deficient in FasL expression were ...

Background: Mikuliczs disease (MD) has been considered as one manifestation of Sjögrens syndrome (SS). Recently, it has also been considered as an IgG4-related disorder.. Objective: To determine the differences between IgG4-related disorders including MD and SS.. Methods: A study was undertaken to investigate patients with MD and IgG4-related disorders registered in Japan and to set up provisional criteria for the new clinical entity IgG4-positive multiorgan lymphoproliferative syndrome (IgG4+MOLPS). The preliminary diagnostic criteria include raised serum levels of IgG4 (,135 mg/dl) and infiltration of IgG4+ plasma cells in the tissue (IgG4+/IgG+ plasma cells ,50%) with fibrosis or sclerosis. The clinical features, laboratory data and pathologies of 64 patients with IgG4+MOLPS and 31 patients with typical SS were compared.. Results: The incidence of xerostomia, xerophthalmia and arthralgia, rheumatoid factor and antinuclear, antiSS-A/Ro and antiSS-B/La antibodies was significantly lower in ...

Consistent with the finding that Fas deficiency might also alter homeostasis of conventional immune cell lineages independently of Eomes, we found that the autoimmune manifestations of ALPS were not affected by the T cell-specific deletion of Eomes (Fig. 2E, 2F). This result was not unexpected because independent lines of evidence have uncoupled DN T cell accumulation from the pathogenic autoantibody production of ALPS (3, 4, 9). Whereas B cell- or DC-specific deficiency of Fas is not sufficient to drive DN T cell expansion, either is sufficient to recapitulate the autoantibody production of ALPS (3, 4). CD4+ T cells, DCs, and B cells are still present and Fas-deficient in lpr/lpr, Eomes F/F, Cd4:Cre+ mice, providing a sufficient cellular network for the elaboration of pathogenic autoantibodies. Taken together, these data suggest that the Eomes-dependent DN T cell population is responsible for the lymphoproliferative phenotype but does not appear to be required for the humoral autoimmunity ...

Pachlopnik Schmid, J; Canioni, D; Moshous, D; Touzot, F; Mahlaoui, N; Hauck, F; Kanegane, H; Lopez-Granados, E; Mejstrikova, E; Pellier, I; Galicier, L; Galambrun, C; Barlogis, V; Bordigoni, P; Fourmaintraux, A; Hamidou, M; Dabadie, A; Le Deist, F; Haerynck, F; Ouachée-Chardin, M; Rohrlich, P; Stephan, J L; Lenoir, C; Rigaud, S; Lambert, N; Milili, M; Schiff, C; Chapel, H; Picard, C; de Saint Basile, G; Blanche, S; Fischer, A; Latour, S (2011). Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency). Blood, 117(5):1522-1529.. Liu, L; Okada, S; Kong, X F; Kreins, A Y; Cypowyj, S; Abhyankar, A; Toubiana, J; Itan, Y; Audry, M; Nitschke, P; Masson, C; Toth, B; Flatot, J; Migaud, M; Chrabieh, M; Kochetkov, T; Bolze, A; Borghesi, A; Toulon, A; Hiller, J; Eyerich, S; Eyerich, K; Gulácsy, V; Chernyshova, L; Chernyshov, V; Bondarenko, A; Grimaldo, R M C; Blancas-Galicia, L; Beas, I M M; Roesler, J; ...

Complete information for FASLG gene (Protein Coding), Fas Ligand, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Complete information for FASLG gene (Protein Coding), Fas Ligand, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

rs763110, also known as -844C,T, is a SNP in the FAS ligand FASLG gene. A meta-analysis of 19 published studies, including 11,105 cancer cases and 11,372 controls, concluded that the rs763110(C;T) and (T;T) genotypes were associated with a significantly reduced (about 0.80x) cancer risk of all cancer types.[PMID 19337311 ...

SERVIOLI, Luisa et al. Blood cytopenias in systemic autoimmune conditions. Arch. Med Int [online]. 2014, vol.36, n. 3, pp.101-109. ISSN 0250-3816.. The hematologic cytopenias are a frequent and potentially dangerous finding in the Systemic Autoimmune Diseases. It may have different etiologies, and for that reason it is important a systematic approach to ensure the correct diagnosis and treatment. In this article, the frequency, etiology, diagnostic approach and treatment of the hematologic cytopenias are reviewed.. Keywords : autoimmune cytopenias; hematologic cytopenias in autoimmune diseases; inflammatory anemia; autoimmune leukopenia; neutropenia in autoimmune diseases. ...

ALP - MedHelps ALP Center for Information, Symptoms, Resources, Treatments and Tools for ALP. Find ALP information, treatments for ALP and ALP symptoms.

Lymphom: Symptome ❗ Befunde ❗ Diagnose ❗ Behandlung ❗ Komplikationen ❗ Ursachen ❗ Epidemiologie ❗ Inzidenz ❗ Prognose ❗ Mehr auf Symptoma.com Der Terminus Lymphom bezieht sich auf eine lymphoproliferative Erkrankung, die mit einer unkontrollierten Vermehrung verschiedener Lymphozytenpopulationen bzw. deren Vorgängerzellen einhergeht.…

Status: Recruiting. Condition Summary: Rare Disorders; Undiagnosed Disorders; Disorders of Unknown Prevalence; Cornelia De Lange Syndrome; Prenatal Benign Hypophosphatasia; Perinatal Lethal Hypophosphatasia; Odontohypophosphatasia; Adult Hypophosphatasia; Childhood-onset Hypophosphatasia; Infantile Hypophosphatasia; Hypophosphatasia; Kabuki Syndrome; Bohring-Opitz Syndrome; Narcolepsy Without Cataplexy; Narcolepsy-cataplexy; Hypersomnolence Disorder; Idiopathic Hypersomnia Without Long Sleep Time; Idiopathic Hypersomnia With Long Sleep Time; Idiopathic Hypersomnia; Kleine-Levin Syndrome; Kawasaki Disease; Leiomyosarcoma; Leiomyosarcoma of the Corpus Uteri; Leiomyosarcoma of the Cervix Uteri; Leiomyosarcoma of Small Intestine; Acquired Myasthenia Gravis; Addison Disease; Hyperacusis (Hyperacousis); Juvenile Myasthenia Gravis; Transient Neonatal Myasthenia Gravis; Williams Syndrome; Lyme Disease; Myasthenia Gravis; Marinesco Sjogren Syndrome(Marinesco-Sjogren Syndrome); Isolated Klippel-Feil ...

Human X-linked inhibitor of apoptosis (XIAP) protein belongs to a family of apoptotic suppressor proteins that share a conserved motif, the baculovirus IAP repeat (BIR). The BIR motif is necessary for antiapoptotic function. XIAP plays a variety of other functional roles, such as also modulation of inflammatory signaling and immunity, mitogenic kinase signaling, cell proliferation, and copper homeostasis. XIAP acts as a caspase inhibitor by binding to the active site of caspase 3 and 7; it also inactivates caspase 9 by preventing it from forming active homodimers. Mutations in the XIAP gene are associated with X-linked lymphoproliferative syndrome. XIAP is also known as baculoviral IAP repeat-containing 4 (BIRC4), inhibitor of apoptosis protein 3 (IAP3), hIAP3, IAP-like protein, API3, ILP1, MIHA, and XLP2.. ...

Human X-linked inhibitor of apoptosis (XIAP) protein belongs to a family of apoptotic suppressor proteins that share a conserved motif, the baculovirus IAP repeat (BIR). The BIR motif is necessary for antiapoptotic function. XIAP plays a variety of other functional roles, such as also modulation of inflammatory signaling and immunity, mitogenic kinase signaling, cell proliferation, and copper homeostasis. XIAP acts as a caspase inhibitor by binding to the active site of caspase 3 and 7; it also inactivates caspase 9 by preventing it from forming active homodimers. Mutations in the XIAP gene are associated with X-linked lymphoproliferative syndrome. XIAP is also known as baculoviral IAP repeat-containing 4 (BIRC4), inhibitor of apoptosis protein 3 (IAP3), hIAP3, IAP-like protein, API3, ILP1, MIHA, and XLP2.. ...

LOS ANGELES - For Jacob Martinez, blood and platelet transfusions are part of daily life. So is confinement to a tiny room sealed off from the contaminates of the outside world. Jacob, 5, of Pico Rivera, has been in his clean room for three months, since he received a bone marrow transplant in October. But that transplant failed, and now a second is needed to make it possible for the boy to produce his own blood. "This is a hard battle," Jacobs father, Peter Martinez, said. "We just stay with him and love him, and make him as comfortable and happy as we can." Jacob suffers from X-linked Lymphoproliferative Syndrome, or XLP, an immune system deficiency. Diagnosed at just a month old, he has been in and out of hospitals his entire life. The disease makes him highly susceptible to infections and could make even mild illness deadly. It affects only boys, and is passed down by female carriers in a family, who display no symptoms. If left untreated, Jacobs life expectancy would be about 10 years. ...

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Recombinant extracellular domain of human FasL (aa 103-281) produced inHEK 293 cellsis fused at the N-terminus to a linker peptide (26 aa) and a FLAG-tag. Glycosylation of rhsSuperFasLigandTM is similar to natural human FasL. 32kDa (nonglycosylated), 35kD

Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.

Техничексие характеристики alps M52_Red_Note, сформировано приложением СпецДевайс. Реальные данные.

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CiteWeb id: 20050000212. CiteWeb score: 2801. DOI: 10.1016/j.immuni.2005.01.016. Regulatory T cell-mediated dominant tolerance has been demonstrated to play an important role in the prevention of autoimmunity. Here, we present data arguing that the forkhead transcription factor Foxp3 acts as the regulatory T cell lineage specification factor and mediator of the genetic mechanism of dominant tolerance. We show that expression of Foxp3 is highly restricted to the subset αβ of T cells and, irrespective of CD25 expression, correlates with suppressor activity. Induction of Foxp3 expression in nonregulatory T cells does not occur during pathogen-driven immune responses, and Foxp3 deficiency does not impact the functional responses of nonregulatory T cells. Furthermore, T cell-specific ablation of Foxp3 is sufficient to induce the identical early onset lymphoproliferative syndrome observed in Foxp3-deficient mice. Analysis of Foxp3 expression during thymic development suggests that this mechanism is ...

In this study, we have demonstrated that xenoantigen-activated DNT cells can eliminate syngeneic B and T cells ex vivo, and adoptive transfer of DNT cells can significantly prolong xenograft survival. We have identified a different mechanism of xenoreactive DNT cell-mediated immune regulation that is dependent on perforin/granzymes, but independent of the Fas-FasL interaction (18, 24). This finding is consistent with the high expression level of granzymes in xenoreactive DNT cells compared with those in CD8+ T cells. Taken together, our data indicate that DNT cells can mediate immune regulation in xenotransplantation by targeting B and T cells.. Our finding that activation of DNT cells could be inhibited by Abs against either rat MHC I or II molecules in the presence of IL-2, implying that the interaction between TCR on DNT cells and xeno-MHC molecules is Ag nonspecific. This notion is supported by crystallographic data showing that CD8+ T cell xenoreactivity is not based on a molecular mimicry ...

This protein protein interaction antibody pair set comes with two antibodies to detect the protein-protein interaction, one against the MAPK8 protein, and the other against the FASLG protein for use in in situ Proximity Ligation Assay. See Publication Reference below. (DI0191) - Products - Abnova

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inproceedings{ARCH15:Benchmark_Quadrotor_Attitude_Control, author = {A. E. C. Da Cunha}, title = {Benchmark: Quadrotor Attitude Control}, booktitle = {ARCH14-15. 1st and 2nd International Workshop on Applied veRification for Continuous and Hybrid Systems}, editor = {Goran Frehse and Matthias Althoff}, series = {EPiC Series in Computing}, volume = {34}, pages = {57--72}, year = {2015}, publisher = {EasyChair}, bibsource = {EasyChair, https://easychair.org}, issn = {2398-7340}, url = {https://easychair.org/publications/paper/mwnd}, doi = {10.29007/dc68 ...

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inproceedings{ARCH17:ARCH_COMP17_Category_Report_Preliminary, author = {Adel Dokhanchi and Shakiba Yaghoubi and Bardh Hoxha and Georgios Fainekos}, title = {ARCH-COMP17 Category Report: Preliminary Results on the Falsification Benchmarks}, booktitle = {ARCH17. 4th International Workshop on Applied Verification of Continuous and Hybrid Systems}, editor = {Goran Frehse and Matthias Althoff}, series = {EPiC Series in Computing}, volume = {48}, pages = {170--174}, year = {2017}, publisher = {EasyChair}, bibsource = {EasyChair, https://easychair.org}, issn = {2398-7340}, url = {https://easychair.org/publications/paper/HxQ}, doi = {10.29007/wmf5 ...

Collection of selected, peer reviewed papers from the International Workshop on Materials and Mechanical Engineering (WMME 2013), November 20-22, 2013, Xianning, China. |br /|The 57 papers are grouped as follows: |br /|I. Research and Processing of Materials, |br /|II. Mechanical Science and Engineering

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