Intentionally using oneself as a research subject.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
The teaching staff and members of the administrative staff having academic rank in a medical school.
The teaching staff and members of the administrative staff having academic rank in an educational institution.
The branch of psychology which seeks to learn more about the fundamental causes of behavior by studying various psychologic phenomena in controlled experimental situations.
The teaching staff and members of the administrative staff having academic rank in a dental school.
The teaching staff and members of the administrative staff having academic rank in a nursing school.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
The assessing of academic or educational achievement. It includes all aspects of testing and test construction.
A genus of small mushrooms in the family Strophariaceae. Some species are known for their hallucinogenic properties.
Human experimentation that is not intended to benefit the subjects on whom it is performed. Phase I drug studies (CLINICAL TRIALS, PHASE I AS TOPIC) and research involving healthy volunteers are examples of nontherapeutic human experimentation.
A series of actions, sometimes symbolic actions which may be associated with a behavior pattern, and are often indispensable to its performance.
A plant genus in the family CONVOLVULACEAE best known for morning glories (a common name also used with CONVOLVULUS) and sweet potato.
A plant genus in the family CAPRIFOLIACEAE known for elderberries.
The plant genus in the Cannabaceae plant family, Urticales order, Hamamelidae subclass. The flowering tops are called many slang terms including pot, marijuana, hashish, bhang, and ganja. The stem is an important source of hemp fiber.
The ability to carry out daily tasks and perform physical activities in a highly functional state, often as a result of physical conditioning.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Contractile tissue that produces movement in animals.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
The use of humans as investigational subjects.
Criminal acts committed during, or in connection with, war, e.g., maltreatment of prisoners, willful killing of civilians, etc.
Human experimentation that is intended to benefit the subjects on whom it is performed.
The use of animals as investigational subjects.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
The part of the face above the eyes.
The largest portion of the CEREBRAL CORTEX in which the NEURONS are arranged in six layers in the mammalian brain: molecular, external granular, external pyramidal, internal granular, internal pyramidal and multiform layers.
An agency of the UNITED STATES PUBLIC HEALTH SERVICE that conducts and supports programs for the prevention and control of disease and provides consultation and assistance to health departments and other countries.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
A plant genus of the family JUGLANDACEAE that provides the familiar walnut.

Live attenuated vaccine trials in medically informed volunteers: a special case? (1/7)

A group of activist clinicians have offered to volunteer for clinical trials of live attenuated HIV vaccines. This has provided an important conceptual challenge to medical ethics, and to work on the development of HIV vaccines. In exploring these issues, this article highlights how the HIV field has altered the content as well as the tone of ethical discourse. The balance of expertise and authority between research subjects and triallists is profoundly changed, raising questions about the limits of voluntarism and differing perspectives on risk-benefit analysis. Care is needed to ensure that the novelty of the situation does not confuse the central ethical and scientific issues.  (+info)

The case for a new system for oversight of research on human subjects. (2/7)

The increasing emphasis on evidence-based clinical practice has thrown into sharp focus multiple deficiencies in current systems of ethical review. This paper argues that a complete overhaul of systems for ethical oversight of studies involving human subjects is now required as developments in medical, epidemiological and genetic research have outstripped existing structures for ethical supervision. It shows that many problems are now evident and concludes that sequential and piecemeal amendments to present arrangements are inadequate to address these. At their core present systems of ethical review still rely on the integrity and judgment of individual investigators. One possible alternative is to train and license research investigators, make explicit their responsibilities and have ethics committees devote much more of their time to monitoring research activity in order to detect those infringing the rules.  (+info)

Homeopathic pathogenetic trials produce specific symptoms different from placebo. (3/7)

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The unreasonable effectiveness of my self-experimentation. (4/7)

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N of 1, two contemporary arm, randomised controlled clinical trial for bilateral epicondylitis: a new study design. (5/7)

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Limits on risks for healthy volunteers in biomedical research. (6/7)

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Self-experimentation and its role in medical research. (7/7)

Although experimentation involving human volunteers has attracted intense study, the matter of self-experimentation among medical researchers has received much less attention. Many questions have been answered only in part, or have been left unanswered. How common is this practice? Is it more common among certain nationalities? What have been the predominant medical fields in which self-experimentation has occurred? How dangerous an act has this proved to be? What have been the trends over time? What is the future likely to bring?From the available literature, I identified and analyzed 465 documented instances of this practice, performed over the course of the past 2 centuries. Most instances occurred in the United States. The peak of self-experimentation occurred in the first half of the 20th century. Eight deaths were recorded. A number of the investigators enjoyed successful careers, including the receipt of Nobel Prizes. Although self-experimentation by physicians and other biological scientists appears to be in decline, the courage of those involved and the benefits to society cannot be denied.  (+info)

Self-experimentation refers to the special case of single-subject research in which the experimenter conducts the experiment on himself or herself. Usually this means that a single person is the designer, operator, subject, analyst, and user or reporter of the experiment. Current champions of self-experimentation include the late Seth Roberts, Tim Ferriss, and a sprawling community of Quantified Self Human scientific self-experimentation principally (though not necessarily) falls into the fields of medicine and psychology. Self-experimentation has a long and well-documented history in medicine which continues to the present day. For example, after failed attempts to infect piglets in 1984, Barry Marshall drank a petri dish of the Helicobacter pylori from a patient, and soon developed gastritis, achlorhydria, stomach discomfort, nausea, vomiting, and halitosis.[citation needed] The results were published in 1985 in the Medical Journal of Australia, and is among the most cited articles from the ...
The Drop Dead Healthy Plan you will see me undertake in Cereal Killers evolved organically throughout a 2 year period of trial, error and omission.. How did I identify my go to foods?. It really was a case of self-experimentation on a grandiose scale with more than a sprinkling of complete ignorance. At no point did I consult any practicing medical or dietary professional and my personal research was conducted from a standing start.. As a lean, fit (5 times a day) carbo loading, low fat food advocate, I figured the medical fraternity would baulk at my quest to drop dead healthy and avoid the heart disease and diabetes prevalent in my family.. Medicine as an industry is reactive you see. It is the business of sickness with little regard for pro-active outliers focused on not getting ill in the first place.. Doctor Doctor I want to never get sick.. I see. So are you sick at the moment?. Not at all.. So why are you here then?. Because I dont want to see you again. Ever.. I think you need to ...
This change in regulation isnt usually simply recognized, and often is criticized for enabling shady supplements to circulate freely on The buyer current market. For everything its not-this system permits people in to possess a much easier access to these potent solutions devoid of watching for the a long time of clinical trials. Frequently, finding the best probiotic for you entails some self-experimentation with distinctive species of bacteria ...
‎Tucker Max shot x-rays across his balls, and it crushed his Testosterone. The solutions offered by the medical community were dangerous, expensive and ineffective, so he began a journey of research and self-experimentation to find a better answer. Through completely natural and healthy s…
Were innovative but we dont experiment on our clients skin. However, Gross does experiment on his own skin, even when it means sporting a rash from something hes testing. I should wear a big badge that says, Im testing products, dont judge me, he says. I cant imagine what the patients think when they see me like that. That self-experimentation helps him produce new innovative products. Topical vitamin D was a huge miss for the industry, Dr. Gross says. I hit on that one summer in the Hamptons. I created something for my wife and me. We tested it, and it worked . Every product that the brand. ... [Read more »]. ...
Lets be clear: Im neither a doctor nor a PhD. I am a meticulous data cruncher with access to many of the worlds best athletes and scientists.. This puts me in a rather unusual position.. Im able to pull from disciplines and subcultures that rarely touch one another, and Im able to test hypotheses using the kind of self-experimentation mainstream practitioners cant condone (though their help behind the scenes is critical). By challenging basic assumptions, its possible to stumble upon simple and unusual solutions to long-standing problems.. Overfat? Try timed protein and pre-meal lemon juice.. Undermuscled? Try ginger and sauerkraut.. Cant sleep? Try upping your saturated fat or using cold exposure.. This book includes the findings of more than 100 PhDs, NASA scientists, medical doctors, Olympic athletes, professional sports trainers (from the NFL to MLB), world-record holders, Super Bowl rehabilitation specialists, and even former Eastern Bloc coaches. Youll meet some of the most ...
There may be other examples. Its difficult to say, because heart disease has not been studied with any rigor until the modern era, when the spread of wheat has occurred in the form of a global spread of white flour and sugar. Even worse, during the first half of the century when this spread was rapidly initiated, wheat was treated with nitrogen trichloride, which created toxic inhibitors of biosynthesis of glutamine and glutathione and led to hysteria in dogs. It was abandoned in US and UK due to concerns of potential human hysteria and in Canada because it was explosive and thus a risk to mill workers. Trying to tease out all these factors using a historical or epidemiological worldview would be incredibly difficult, so we need rigorous science in the form of publication-worthy literature, self-experimentation, and careful clinical practice. Thanks for being part of the solution ...
Press Release issued Oct 17, 2013: The Fat Loss Factor Program is one of the many popular diet programs that are now gripping this appearance conscious country. It has been developed by a husband and wife tandem - Dr. Michael Allen and Lori. They both were overweight individuals but after a series of self-experimentation, they have created a combination of nutritional and physical factors that attributed to their weight loss. Currently, because of the so-called program, they are now enjoying their healthy new curves.
Vanessa Bennington found her way in the health and fitness worlds through a unique combination of education, personal experience, and self-experimentation. During high school, she dropped from a weight of around 140lbs on her 54″frame, to barely 90lbs.
Vanessa Bennington found her way in the health and fitness worlds through a unique combination of education, personal experience, and self-experimentation. During high school, she dropped from a weight of around 140lbs on her 54″frame, to barely 90lbs.
Are Long-acting Insulin Analogues Better Than Isophane Insulin? The theoretic benefits of newer insulin analogues might result in fewer macro- and microvascular adults had diabetes and 38 percent But in the case of intermittent fasting which Ill explain below Im glad that I decided to do some self-experimentation and see if it would work for me. Brown Cane Sugar Benefits insulator definition a material of such low conductivity that the flow of current through it is negligible. 9news coverage of Lefthand with Vernon B.. O Type 3 Support (Friends & Family). This video takes a student through the correct techniques for monitoring a patients blood glucose levels. Also included: Target test scores for your diabetes health.. How to Host a Cookie Exchange Party By: What causes diabetes fatigue I sleep from midnight to noon each day. Das Normalinsulin welches zum Essen weil ich abends nicht mehr gut schlafe. Those who suffer from diabetes often experience a swollen leg from high blood sugar it is one ...
VLC (very low carb) diet reduces mucus production, since mucus is primarily made of water and sugars. Mucus is made from glycoproteins; when these proteins are broken down in gluconeogenesis, they are unavailable to be used as mucus. This dries out the eyes, mouth, and intestines, depriving the body of a crucial barrier against irritants and pathogens and increasing the risk of infection and gastrointestinal cancers. During 2 years on a zero-carb diet, Dr. Jaminet personally noticed uncomfortable dryness in his eyes and mouth, and self-experimentation revealed glucose deficiency as the major culprit. He cites other low-carb dieters who have had similar experiences, as well as a study showing that dry membranes commonly occur during starvation, when the body breaks down its stores of protein to maintain glucose levels.. Delete ...
If you need yet another reason to breastfeed your baby (or feel guilty that you didnt), heres a new study that reinforces the benefits of ...
The initial focus of the CCDGs will be in cardiovascular disease (early onset heart disease, hemorrhagic stroke), and neuropsychiatric disease (autism). The program is designed to consider additional example diseases over time. Currently, the program is considering additional studies in autoimmune/inflammatory diseases (such as asthma, Type 1 diabetes, and inflammatory bowel disease), and bone disorders (osteoporosis). The choice of these, and any additional diseases, will be made based on criteria derived from those stated in the original RFA. These include the ability to undertake a comprehensive, well-powered study, the potential of the new example disease to broaden the range of different disease architectures being studied, or to explore new study designs. At a future date, the CCDG program will develop procedures to identify new studies with the involvement of the scientific community, either through direct interactions or through collaborations with other NIH institutes and centers. ...
What is the new limit for purchasing Sudafed as of June 2011? - I was told lately that i was over else on my sudafed purchase limit plus cannot work out why. I have ...
Dette papir demonstrerer en protokol til omarbejdning eksperimentelle forenklet model lofter i konservative og aggressive grænser for...
Dont wish your life away, or you may end up getting what you wished for a little sooner than expected, according to the results of a new study published i
Are you one of those people whos always in a relationship? Or maybe youre perpetually single? Well, your status might have something to do with your genes, according to a new study out of China.
Patients and their caregivers desire information about upcoming imaging examinations, but many are not getting it, according to a new study.
In a new study, researchers found structural changes in the brains of the diplomats who had served in Cuba compared with a similar control group.
In an effort to help protect the supply chain and continue to keep shelves stocked, H-E-B announced new temporary purchasing limits on certain items.
In theory is it possible for a man to grow to a large size...using current or future technology? By tweaking genes and/or using drugs? And also adjusting foo...
A new study suggests that yet another one of life's greatest pleasures might lead to cancer. A top surgical doctor in Australia says kissing can lead to the development of head and neck
A deeper insight into the humans sense of touch has been provided by a new study recently. The sense of touch has been generally taken for granted in neuroscience.
The long history of indigenous use led to research and trials on this great trees potential use as a homeopathic remedy. The authors describe the historical background, the nature of the tree with its environment and the homeopathic pathogenetic trial along with the themes and symptoms that emerged. A brief correlation with other fig remedies is also discussed.
View Notes - 2_1999 from BIOL 3800 at North Texas. 1999 Molecular Biology Exam #2 - Using Molecular Tools There is no time limit on this test, though I have tried to design one that you should be
A new study published in Pharmacogenomics suggests that a persons response to anticancer drug treatments is strongly related to their genetic ancestry.
Antimicrobial resistance is everywhere and has the potential to affect anyone, of any age, in any country. A new study published in Nature and made at the…
A new study upends our assumptions about the value of blog posts, revealing that a posts lifespan is nearly 24 times what we thought.
Some people taking blood-thinning medications might be getting the wrong dose, according to a new study. More s...
Kroger, the parent company of Smiths Market, said Friday it has reinstated a two-item limit on products like toilet paper and disinfecting cleaning products.. To ensure all customers have access to what they need, weve proactively and temporarily set purchase limits to two per customer on certain products, Kroger said in a statement received by St. George News.. At Smiths Market on Bluff Street in St. George Friday, the market itself appeared more filled than usual. However, there was plenty of toilet paper and paper towel products stocked, as well as disinfecting products. Signs were placed in the aisles informing shoppers of the two-item limit.. St. George News has learned that Albertsons also now has a two-item limit on both cleaning products and toilet paper. Meanwhile, Walmart and Lins Market presently have no limits on toilet paper but do have a two-item limit of disinfectants and disinfecting wipes.. The one local market that doesnt have limits on either at this point is Harmons, ...
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View Notes - MolExam1_2010 from BIOL 3800 at North Texas. Spring 2010 Molecular Biology Exam #1 - Learning the Tools There is no time limit on this test, though I have tried to design one that you
kkleiner writes For years, research has shown that aspirin is beneficial in preventing heart attacks. Now new studies support its ability to prevent cancer as well. The studies, involving tens of thousands of participants over many decades, show reductions of cancer incidence (both short- and long...
Antimicrobials are a wide variety of compounds with the attack for the destruction or inhibition of microorganisms.This article describes the using of recycled α-hydroxyphosphonic acids grafted on styrene-divinylbenzene copolymeras a recycled material for new study of antimicrobial tests.. ...
Running red lights. Driving at high speeds. Crossing center lines into the opposite lanes. Getting into accidents -- even hitting pedestrians. A new study found these were some of the
A new study determined that subduing the human immune system in the early stages of SARS-CoV-2 infection might dramatically reduce the likelihood of fatal outcomes.
Its a result to make every regular theatregoer rejoice: watching a live theatre performance can stimulate your cardiovascular system like healthy cardio exercise, a new study suggests.
(PhysOrg.com) -- Theorists have long wondered how massive stars--up to 120 times the mass of the Sun--can form without blowing away the clouds of gas and dust that feed their growth. But the problem turns out to be less mysterious ...
Researchers at the University of Maryland have developed a method that helps an adult recover function in an eye that has been damaged and dysfunctional from birth.
It seems every week the SGLT-2 inhibitors are in the news, one time good and one time bad. Now there is a new study that shows that these products may have
Tags: Revisiting Space. Space and Place in European Cinema. New Studies in European Cinema Band 2. 385 Seiten, Wendy Everett & Axel Goodbody (ed.), New studies in European cinema ; Vol. 2, PDF EBooks, download online, epub files, books online, pdf epub books, download Now, Revisiting Space. Space and Place in European Cinema. New Studies in European Cinema Band 2. 385 Seiten, Wendy Everett & Axel Goodbody (ed.), New studies in European cinema ; Vol. 2, free Online download, ebook online free read and download, Revisiting Space. Space and Place in European Cinema. New Studies in European Cinema Band 2. 385 Seiten, Wendy Everett & Axel Goodbody (ed.), New studies in European cinema ; Vol. 2, pdf file, epub download free, online download, mega upload.. ...
The latest issue of IAAF New Studies in Athletics special edition focused on the 400 meters: The 400 metres by Jurgen Schiffer The aerobic mechanism in
Lawrence B. Werlin presented New Study at Pacific Coast Reproductive Society (PCRS) Annual Conference at IRVINE, Calif. Learn More.
Rochester, NY (PRWEB) March 1, 2010 -- New study revealed that treatment with the natural antiviral supplement Gene-Eden caused a complete recovery of the
According to a new study ran by sociologist Eric Anderson from University of Winchester, men who dont cheat are setting themselves up for
Just in time for the next noreaster, a study has revealed the most common snow-related injuries. The research also showed that snow-shoveling can put heart rates above the recommended limits after only two minutes.
A new study claims that swearing can make you stronger. The research found that in certain situations swearing out loud may be advantageous.
A new study found that on the days kids eat pizza, they likely take in more calories, fat and sodium than on other days. On any given day in the United Sta
For more than a decade, researchers have believed that aging cells damage the tissue around them, and that this damage underlies a number of age-related disorders. Now a new study in mice appears to confirm this. The study shows that selectively eliminating those aging, or
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Session 10 - Autoexperimentation. *Jonas, H. (1969). Philosophical reflections on experimenting with human subjects. Daedalus, ...
Werner Forssmann: A Pioneer of Interventional Cardiology and Auto-Experimentation.. Afshar A, Steensma DP, Kyle RA. ...
B.R. Cohens Annals of Science: Vol III: Substance Abusers Are Scientists Too: Vignettes on Auto-Experimentation ...
B.R. Cohens Annals of Science: Vol III: Substance Abusers Are Scientists Too: Vignettes on Auto-Experimentation ...
Observations on the Tradition of Autoexperimentation in Medicine. The Use of Human Beings in Research with Special Reference to ...
Autoexperimentation with LSD does not exhaust its didactic potential. Another learning experience of great value is ...
Fingerprint Dive into the research topics where Mona Shattell is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
SEE ALSO: Aging and the Aged: Healthcare and Research Issues; AIDS: Healthcare and Research Issues; Autoexperimentation; ...
SEE ALSO: Aging and the Aged: Healthcare and Research Issues; AIDS: Healthcare and Research Issues; Autoexperimentation; ...
Autoexperimentation.. 650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM. Topical term or geographic name as entry element. Human ...
Autoexperimentation * CtGEM typing: Discrimination of Chlamydia trachomatis ocular and urogenital strains and major ...
Fingerprint Dive into the research topics where Psychology is active. These topic labels come from the works of this organisations members. Together they form a unique fingerprint. ...
Autoexperimentation.. Human experimentation.. Patient selection.. Research subjects.. International cooperation. ...
Humans , Male , Female , Guinea Pigs , Autoexperimentation/ethics , Biomedical Research , Drugs, Investigational , Ethics, ...
This led me to turn to auto-experimentation. Each month I would pick a different workout routine and log my results. However, ...
This graph shows the total number of publications written about "Human Experimentation" by people in Harvard Catalyst Profiles by year, and whether "Human Experimentation" was a major or minor topic of these publication ...
Scientists seem to have a fascination with autoexperimentation…Robert Koch was no exception. He decided to eat 1/2 kg of butter ...
Full text: Available Index: LILACS (Americas) Main subject: Drugs, Investigational / Risk Assessment / Autoexperimentation / ... Humans , Male , Female , Guinea Pigs , Autoexperimentation/ethics , Biomedical Research , Drugs, Investigational , Ethics, ...
Through "auto-experimentation," these intrepid souls learned the effects of various gases on their own human bodies. ...
Autoexperimentation H1.770.644.302.100 Autogenic Training F4.754.103 F4.754.424.386 Autonomic Fibers, Preganglionic A8.675. ...
Wims brave auto-experimentation, combined with his profound desire to bring his discoveries firmly under the scrutiny of ...
The Becker Archives serve as the historical repository for Washington University School of Medicine in St. Louis and the affiliated hospitals at the medical center. The archival collections document the history of the School of Medicine, including its faculty and students, as well as the institutional history of Barnes-Jewish Hospital and St. Louis Childrens Hospital.
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B.R. Cohens Annals of Science: Vol III: Substance Abusers Are Scientists Too: Vignettes on Auto-Experimentation ...
A lifetime of auto-experimentation has made him powerful, but his vastly enhanced metabolism means he must feed constantly to ...
Air purifier filters, Gates Belts, Lucas Oil products, Vehicle Lighting & Strobes Auto. Experimentation, we ve compiled a ...
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