Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone.
The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.
Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.
Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.
Disorders of verbal and nonverbal communication caused by receptive or expressive LANGUAGE DISORDERS, cognitive dysfunction (e.g., MENTAL RETARDATION), psychiatric conditions, and HEARING DISORDERS.
The transfer of information from experts in the medical and public health fields to patients and the public. The study and use of communication strategies to inform and influence individual and community decisions that enhance health.
Equipment that provides mentally or physically disabled persons with a means of communication. The aids include display boards, typewriters, cathode ray tubes, computers, and speech synthesizers. The output of such aids includes written words, artificial speech, language signs, Morse code, and pictures.
Transmission of emotions, ideas, and attitudes between individuals in ways other than the spoken language.
Cellular signaling in which a factor secreted by a cell affects other cells in the local environment. This term is often used to denote the action of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS on surrounding cells.
Those factors, such as language or sociocultural relationships, which interfere in the meaningful interpretation and transmission of ideas between individuals or groups.
The interactions between physician and patient.
A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)
A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.
Cell surface receptors for AUTOCRINE MOTILITY FACTOR, which is the secreted form of GLUCOSE-6-PHOSPHATE ISOMERASE. The receptor has an unusual composition in that it shares some structural similarities with G-PROTEIN-COUPLED RECEPTORS and functions as an ubiquitin protein ligase when internalized.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The transmission of messages to staff and patients within a hospital.
Communication, in the sense of cross-fertilization of ideas, involving two or more academic disciplines (such as the disciplines that comprise the cross-disciplinary field of bioethics, including the health and biological sciences, the humanities, and the social sciences and law). Also includes problems in communication stemming from differences in patterns of language usage in different academic or medical disciplines.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Utilization of all available receptive and expressive modes for the purpose of achieving communication with the hearing impaired, such as gestures, postures, facial expression, types of voice, formal speech and non-speech systems, and simultaneous communication.
A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.
Interactions between health personnel and patients.
The means of interchanging or transmitting and receiving information. Historically the media were written: books, journals, newspapers, and other publications; in the modern age the media include, in addition, radio, television, computers, and information networks.
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.
The interactions between the professional person and the family.
Signal molecules that are involved in the control of cell growth and differentiation.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
The reciprocal interaction of two or more professional individuals.
A mode of communication concerned with inducing or urging the adoption of certain beliefs, theories, or lines of action by others.
The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.
Recording of information on magnetic or punched paper tape.
Sounds used in animal communication.
Culture media containing biologically active components obtained from previously cultured cells or tissues that have released into the media substances affecting certain cell functions (e.g., growth, lysis).
Interaction between the patient and nurse.
Established cell cultures that have the potential to propagate indefinitely.
Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Transmission of information over distances via electronic means.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
The use of persons coached to feign symptoms or conditions of real diseases in a life-like manner in order to teach or evaluate medical personnel.
The adopting or performing the role of another significant individual in order to gain insight into the behavior of that person.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The electronic transmission of radiological images from one location to another for the purposes of interpretation and/or consultation. Users in different locations may simultaneously view images with greater access to secondary consultations and improved continuing education. (From American College of Radiology, ACR Standard for Teleradiology, 1994, p3)
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Elements of limited time intervals, contributing to particular results or situations.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. (1/1262)

The EPH family is the largest subfamily of receptor protein tyrosine kinases, consisting of the EPHA and EPHB subgroups. Ephrin-B1, ephrin-B2, and ephrin-B3 are ligands of the EPHB subgroup and are encoded by the EFNB1, EFNB2, and EFNB3 genes, respectively. We have shown previously that EPHB2 transcripts are expressed in six small cell lung carcinoma (SCLC) cell lines. In this study, we examined the expression of EPHB1, EPHB2, EPHB3, EPHB4, and EPHB6 in 4 SCLC tumor specimens and 14 cell lines including 3 cell lines derived from these tumor specimens. To investigate whether potential autocrine loops of EPHB receptors and ephrin-B ligands exist in SCLC, the expression of EFNB1, EFNB2, and EFNB3 was also examined. Our data show that transcripts encoding multiple members of the EPHB subgroup and the ephrin-B subgroup are coexpressed in SCLC cell lines and tumors. These results suggest that the EPHB subgroup receptor kinases may modulate the biological behavior of SCLC through autocrine and/or juxtacrine activation by ephrin-B ligands that are expressed in the same or neighboring cells.  (+info)

Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. (2/1262)

The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by influenza virus infection and by double-stranded (ds)RNA. This activation results not only in increased antigen presentation and T cell stimulatory capacity, but also in resistance to the cytopathic effect of the virus, mediated by the production of type I interferon, and upregulation of MxA. Because dsRNA stimulates both maturation and resistance, DCs can serve as altruistic antigen-presenting cells capable of sustaining viral antigen production while acquiring the capacity to trigger naive T cells and drive polarized T helper cell type 1 responses.  (+info)

Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1alpha. (3/1262)

PURPOSE: The matrix metalloproteinase gelatinase B is synthesized by cells at the leading edge of the corneal epithelium migrating to heal a wound. Recent data from the authors' laboratory suggest that excessive synthesis contributes to repair defects. The goal of the study reported here was to investigate mechanisms controlling gelatinase B production by corneal epithelial cells. METHODS: Freshly isolated cultures of corneal epithelial cells and early passage stromal fibroblasts from rabbit were used for these studies. RESULTS: In a previous study, it was found that the cytokine interleukin (IL)-1alpha is released into the culture medium of corneal epithelial cells more efficiently when they are plated at low density with limited cell-cell contact than when plated at high density. In this study, we show that production of gelatinase B by these cells is similarly affected by cell plating density. However, it is further demonstrated that these two events are not dependent on one another but occur in parallel: IL-1alpha does not regulate gelatinase B production (synthesis), nor was there evidence that any other secreted autocrine cytokine acts as mediator. Instead, our data suggest that gelatinase B production is downregulated directly by high cell density and indicate a connection to the level of protein kinase C activity. Nevertheless, the anticancer agent suramin, which blocks collagenase synthesis by interfering with autocrine cytokine-receptor interactions, still inhibits synthesis of gelatinase B. CONCLUSIONS: Unlike collagenase synthesis by corneal stromal fibroblasts, production (synthesis) of gelatinase B does not appear to be controlled by secreted autocrine cytokines but can still be inhibited by suramin. Suramin may make an effective therapeutic agent for controlling pathologic overproduction of gelatinase B in corneal ulcers.  (+info)

Pituitary adenylate cyclase-activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells. (4/1262)

There is increasing evidence that hormones play an important role in the control of endothelial cell function and growth by regulating the production of vascular endothelial growth factor (VEGF). VEGF regulates vascular permeability and represents the most powerful growth factor for endothelial cells. In the normal anterior pituitary, VEGF has been detected only in folliculostellate (FS) cells. In the present study, the regulation of the release of VEGF from FS-like mouse TtT/GF cells, and from FS cells of rat pituitary monolayer cell cultures was investigated using a specific VEGF ELISA. Basal release of VEGF was demonstrated in cultures of both TtT/GF cells and rat pituitary cells. Interestingly, the VEGF secretion was stimulated by both forms of pituitary adenylate cyclase-activating polypeptide (PACAP-38 and PACAP-27), indicating that this hypothalamic peptide regulates endothelial cell function and growth within the pituitary. VEGF secretion was also stimulated by interleukin-6 (IL-6) whereas basal, IL-6- and PACAP-stimulated secretion was inhibited by the synthetic glucocorticoid dexamethasone. The inhibitory action of dexamethasone was reversed by the glucocorticoid receptor antagonist RU486, suggesting that in FS cells functional glucocorticoid receptors mediate the inhibitory action of glucocorticoids on the VEGF secretion. The endocrine and auto-/paracrine control of VEGF production in pituitary FS cells by PACAP, IL-6 and glucocorticoids may play an important role both in angiogenesis and vascular permeability regulation within the pituitary under physiological and pathophysiological conditions.  (+info)

Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets. (5/1262)

We compared several responses in thrombin-stimulated and collagen (type I)-stimulated platelets with and without forskolin and inhibitors of autocrine stimulation (IAS: an ADP-removing system of creatine phosphate/creatine phosphokinase, Arg-Gly-Asp-Ser peptide to prevent fibrinogen/fibronectin binding to GPIIb/IIIa, SQ 29.548 as a thromboxane A2 receptor antagonist, cyproheptadine as a serotonin receptor antagonist, BN 52021 as a platelet-activating factor receptor antagonist). The pattern of tyrosine-phosphorylated proteins, the phosphorylation of lipids in the polyphosphoinositide cycle and phosphorylation of pleckstrin (P47) were studied as markers for signal-transducing responses, exposure of CD62 (P-selectin) and CD63 (Glycoprotein 53), as well as secretion of ADP + ATP and beta-N-acetyl-glycosaminidase were studied as final activation responses. Clear differences between thrombin-stimulated and collagen-stimulated platelets were observed. First, practically all protein-tyrosine phosphorylation induced by thrombin was inhibited by IAS, while a partial inhibition was observed for collagen; the phosphorylation due to collagen alone was apparently stimulated by elevation of cAMP. Secondly, the other responses to thrombin were inhibited by increased levels of cAMP, independent of autocrine stimulation. In contrast, only the autocrine part of the collagen-induced responses was inhibited by elevation of cAMP. Thus, the inhibition by elevated cAMP seen in collagen-stimulated platelets seems to be due to removal of the G-protein-mediated activation from secreted autocrine stimulators either by IAS or forskolin. The remaining activity is a pure collagen effect which is not affected by elevated levels of cAMP.  (+info)

Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid. (6/1262)

PURPOSE: Expression of the genes for collagenase and interleukin-1alpha (IL-1alpha) are induced as stromal cells become activated to the repair fibroblast phenotype after injury to the cornea. This investigation examines the mechanisms whereby expression of these genes is inhibited by transforming growth factor-beta (TGF-beta), dexamethasone (DEX), or retinoic acid (RET A). METHODS: A model of freshly isolated cultures of corneal stromal cells and early passage cultures of corneal fibroblasts was used in these studies. This model reproduces the events of stromal cell activation in the corneal wound. RESULTS: In early passage cultures of corneal fibroblasts, expression of collagenase is under obligatory control by autocrine IL-1alpha. IL-1alpha controls its own expression through an autocrine feedback loop that is dependent on transcription factor NF-kappaB. TGF-beta, DEX, and RET A were each effective inhibitors of collagenase gene expression in these cells. Furthermore, these agents have the capacity to inhibit expression of IL-1alpha and this was correlated with their ability to affect DNA-binding activity of NF-kappaB. However, TGF-beta, DEX, and RET A were also effective inhibitors of the low level of collagenase expressed by freshly isolated corneal stromal cells that cannot express IL-1alpha. CONCLUSIONS: In cells with an active IL-1alpha autocrine loop there are at least two distinct signaling pathways by which collagenase gene expression can be modulated. The results of this study demonstrate that TGF-beta, DEX, and RET A differentially inhibit collagenase and IL-1alpha gene expression. This information will be useful in the design of therapeutic modalities for fibrotic disease in the cornea and other parts of the eye.  (+info)

The role of macrophage cell death in tuberculosis. (7/1262)

Studies of host responses to infection have traditionally focused on the direct antimicrobial activity of effector molecules (antibodies, complement, defensins, reactive oxygen and nitrogen intermediates) and immunocytes (macrophages, lymphocytes, and neutrophils among others). The discovery of the systems for programmed cell death of eukaryotic cells has revealed a unique role for this process in the complex interplay between microorganisms and their cellular targets or responding immunocytes. In particular, cells of the monocyte/macrophage lineage have been demonstrated to undergo apoptosis following intracellular infection with certain pathogens that are otherwise capable of surviving within the hostile environment of the phagosome or which can escape the phagosome. Mycobacterium tuberculosis is a prototypical 'intracellular parasite' of macrophages, and the direct induction of macrophage apoptosis by this organism has recently been reported from several laboratories. This paper reviews the current understanding of the mechanism and regulation of macrophage apoptosis in response to M. tuberculosis and examines the role this process plays in protective immunity and microbial virulence.  (+info)

Ligation of Fc gamma RII (CD32) pivotally regulates survival of human eosinophils. (8/1262)

The low-affinity IgG Fc receptor, FcgammaRII (CD32), mediates various effector functions of lymphoid and myeloid cells and is the major IgG Fc receptor expressed by human eosinophils. We investigated whether FcgammaRII regulates both cell survival and death of human eosinophils. When cultured in vitro without growth factors, most eosinophils undergo apoptosis within 96 h. Ligation of FcgammaRII by anti-CD32 mAb in solution inhibited eosinophil apoptosis and prolonged survival in the absence of growth factors. Cross-linking of human IgG bound to FcgammaRII by anti-human IgG Ab or of unoccupied FcgammaRII by aggregated human IgG also prolonged eosinophil survival. The enhanced survival with anti-CD32 mAb was inhibited by anti-granulocyte-macrophage-CSF (GM-CSF) mAb, suggesting that autocrine production of GM-CSF by eosinophils mediated survival. In fact, mRNA for GM-CSF was detected in eosinophils cultured with anti-CD32 mAb. In contrast to mAb or ligands in solution, anti-CD32 mAb or human IgG, when immobilized onto tissue culture plates, facilitated eosinophil cell death even in the presence of IL-5. Cell death induced by these immobilized ligands was accompanied by DNA fragmentation and was inhibited when eosinophil beta2 integrin was blocked by anti-CD18 mAb, suggesting that beta2 integrins play a key role in initiating eosinophil apoptosis. Thus, FcgammaRII may pivotally regulate both survival and death of eosinophils, depending on the manner of receptor ligation and beta2 integrin involvement. Moreover, the FcgammaRII could provide a novel mechanism to control the number of eosinophils at inflammation sites in human diseases.  (+info)

Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
Sulf-2 knockdown effect on autocrine Wnt signaling (a) H292, Calu6, and P-ST cells were transfected with TOP/FOP flash reporter system, then cultured in presenc
Insulin-like growth factors (IGFs) play an important role in the pathogenesis of several neoplasias and the IGF-binding proteins (IGFBPs) may have a role as autocrine/paracrine factors in regulating the local actions of the IGFs. In the present study we investigated IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3 production in cultured media from three human lung cancer cell lines (Calu-3, Calu-6, A549) and in human neoplastic and normal lung tissue samples obtained at surgery from 8 patients. Calu-6 cells secreted much more IGF-II than Calu-3 and A549 (190, 25, and 5 ng/107 cells respectively) and much less IGF-I (0.7, 13, and 5 ng/107 cells). Conversely, IGFBP-1 and IGFBP-3 were most abundant in media conditioned by CALU-3 (13 and 120 ng/107 cells respectively) and least abundant in CALU-6 (,1 ng/107 cells). Molar ratio between IGF-I+IGF-II and IGFBP-1+IGFBP-3 was much higher in Calu-6 which is also the most actively replicating cell line. Regarding IGFBP-2 we found a higher concentration in ...
The cytokine IL-15 appears to mimic the stimulatory activity of IL-2 on lymphocytes by utilizing part of the IL-2R complex. Although effects of IL-15 on Mphi activities have not previously been reported, its derivation from activated Mphi suggested a possible autocrine role in regulating Mphi functions and prompted us to determine whether IL-15 modulated LPS-activated Mphi cytokine production. Whereas high IL-15 concentrations enhanced proinflammatory (i.e., TNF-alpha, IL-1, and IL-6) and anti-inflammatory (i.e., IL-10) cytokine production by two- to sixfold, extremely low IL-15 concentrations (picomolar to attomolar range) markedly and selectively suppressed Mphi proinflammatory, but not anti-inflammatory, cytokine production by two- to fourfold. The stimulation (but not the suppression) of TNF-alpha production by IL-15 required the (IL-2/IL-15) receptor beta chain, as demonstrated by receptor subunit-blocking studies and lack of stimulation of Mphi from IL-2Rbeta-deficient mice. Conversely, ...
Spontaneous interleukin-6 (IL-6) production has been observed in various tumors and implicated in the pathogenesis, progression and drug resistance in cancer. However, the regulation of IL-6 autocrine production in cancer cells is not fully understood. IL-6 is auto-regulated in many types of cell. Two of the three major downstream pathways of IL-6, MEK/extracellular signal-related kinase (Erk) pathway and phosphatidylinositol 3-kinase (PI3-K)/Akt pathway, have been shown to regulate IL-6 expression through the activation of AP-1 and NF-κB. However, it is not clear what the role of Janus kinase (Jak) 2/signal transducer and activator of transcription (Stat) 3 pathway. This study was designed to determine the role of Jak2/Stat3 pathway in the regulation of IL-6 autocrine production in cancer cells. Inhibitors of Jak2/Stat3, MEK/Erk and PI3-K/Akt pathways down-regulated IL-6 secretion in the lung adenocarcinoma PC14PE6/AS2 (AS2) cells, which spontaneously secreted IL-6 and possessed constitutively
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Morbidity and mortality associated with increased white fat accumulation in visceral fat depots have focused attention on the pathways regulating the development of this tissue during embryogenesis, in adulthood, and while under the influence of obesogenic diets. Adipocytes undergo clonal expansion, …
Here, we demonstrated that depolarization of DMH neurons triggers the somatodendritic release of CCK, which acts as an autocrine signal to enhance NMDAR function and liberate NO. Subsequent retrograde NO signaling stimulates the release of GABA from presynaptic terminals in the DMH. These observations provide two critical pieces of information: first, they provide, to the best of our knowledge, the first report of somatodendritic release of the neuropeptide CCK in the brain. Second, they describe a novel form of synaptic regulation in which postsynaptic depolarization enhances synaptic inhibition. The latter observation is particularly intriguing because it provides an example of a feedback system in which a neuron quenches its own excitability by increasing the release of GABA from its afferents. This stands in contrast to the widespread inhibition of neurotransmitter release reported in multiple brain regions following postsynaptic depolarization and the subsequent liberation of eCBs (Wilson ...
Whereas angiogenesis presents many potential therapeutic targets, the VEGFR2 signal pathway has emerged as a primary paracrine/autocrine regulator of endothelial cell biology (18-20). Preclinical studies show that pazopanib is a potent inhibitor of all three VEGF receptors in vitro and that it inhibits HUVEC proliferation in response to VEGF. Although pazopanib is ,30-fold selective for VEGF-induced endothelial cell proliferation compared with that induced by bFGF, it inhibits both VEGF- and bFGF-mediated angiogenesis in vivo. This apparent paradox can be explained by earlier observations that bFGF induces VEGF production in endothelial and other stromal cells (18) and that anti-VEGF antibody can block angiogenesis induced by bFGF in the Matrigel plug assay (data not shown). Pazopanib inhibits the growth of a broad range of human tumor xenografts in mice, and a single p.o. dose of 30 mg/kg inhibits VEGF-induced VEGFR2 phosphorylation in vivo.. We hoped to use data obtained from preclinical ...
Stimulation of almost all mammalian cell types leads to the release of cellular ATP and autocrine feedback through a diverse array of purinergic receptors. Depending on the types of purinergic receptors that are involved, autocrine signalling can promote or inhibit cell activation and fine-tune func …
Research: hormone/paracrine/autocrine regulation of the renal microcirculation, calcium signaling in vascular smooth muscle cells, pathophysiology of hypertension ...
Under serum-free conditions, malignant RMS cells maintain proliferation through autocrine mechanisms (21 , 57 , 59) and exhibit a relatively low level of spontaneous apoptosis, similar to that observed when cells are cultured under serum-containing conditions. These malignant cells differ, therefore, from several nonmalignant cell types, which undergo apoptosis under conditions of serum withdrawal. We showed previously that rapamycin potently induces growth arrest in Rh1 and Rh30 RMS cells under these conditions of culture. However, in the presence of serum, Rh1 cells were highly resistant to growth inhibition by rapamycin. Consequently, it was of interest to determine which components in serum protected these cells. We found that, under serum-free conditions of growth, IGF-I completely substituted for serum in causing rapamycin resistance in Rh1 cells. Exogenous IGF-I abrogated growth arrest in Rh1 cells, whereas Rh30 cells remained arrested even in the presence of IGF-I. Rescue was not due to ...
A model of autocrine signaling in cultures of suspended cells was developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime were derived. Interferon signaling by dendritic immune cells were considered as an illustration ...
Activation via the CD3 and CD16 pathway mediates interleukin-2-dependent autocrine proliferation of granular lymphocytes in patients with granular lymphocyte proliferative disorders. is an eagle-i resource of type Journal article at Oregon Health & Science University.
Down syndrome (DS; trisomy 21) is the most common genetic cause of mental retardation, affecting about one in every 800 individuals. About 60% of the genes on human chromosome 21 are present on mouse chromosome 16 and mouse trisomy 16 (Ts16) has been studied as a potential model for DS. Cultured hippocampal neurons from embryonic Ts16 mice undergo accelerated death by apoptosis in vitro compared with neurons from Euploid littermates. The purpose of this study was to determine the molecular mechanism underlying this accelerated death. Brain-derived Neurotrophic Factor (BDNF), acting through its receptor, trkB, is a well-described autocrine survival factor for hippocampal neurons. BDNF binding to trkB initiates receptor dimerization, autophosphorylation, and activation of several signaling pathways, including AKT and ERK, two signal transduction molecules whose activation by phosphorylation promotes cell survival. To test whether BDNF promoted autocrine survival in Euploid and Ts16 neuronal ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
A large number of cells in the airways, such as eosinophils, mast cells, lymphocytes, neutrophils and ASM cells, contribute to the pathogenesis of inflammatory airway diseases. Here we specifically discuss potential anti-inflammatory interventions that target ASM-driven inflammation.. As mentioned earlier, ASM cells are potential targets for glucocorticosteroid therapy. Other workers and ourselves have recently demonstrated that the expression and secretion of pro-inflammatory cytokines and chemokines by ASM cells in vitro can be inhibited by glucocorticosteroid treatment [11,12,17,25,26,32,36,40]. COX-2 induction and the resulting production of arachidonic acid metabo-lites could similarly be inhibited by treatment with dexa-methasone [13,51]. Suppression of the COX-2 pathway, on the contrary, may result in deleterious consequences considering the bronchoprotective properties of PGE2 in asthmatic airways.. Mechanistically, it has been proposed that glucocorticoid receptors interact with ...
In this study, we showed that exogenously supplied VEGF and TGF-β rapidly increased Cx43 expression in cultured neonatal rat ventricular myocytes in a manner similar to the effects induced by brief intervals of linear pulsatile stretch. We also showed that specific antibodies against either VEGF or TGF-β blocked stretch-induced upregulation of Cx43 expression. Stretch-conditioned medium contained increased levels of VEGF and was able to stimulate Cx43 expression in cells not subjected to stretch. Anti-VEGF antibody blocked the effects of exogenous TGF-β on Cx43 expression but anti-TGF-β antibody did not block the VEGF effect. Thus, we confirmed original observations by Seko et al3 that pulsatile stretch stimulates secretion of VEGF, mediated at least in part by TGF-β, and we now provide evidence that directly implicates these pathways in stretch-mediated upregulation of Cx43.. It is likely that pulsatile stretch causes secretion of multiple mediators from cardiac myocytes and nonmyocytic ...
My research program focuses on the regulation of cholangiocyte proliferation/damage during cholangiopathies. My studies have demonstrated the key role of a number of factors such as vascular and nerve factors, melatonin, secretin, biogenic amines and sex hormones (expressed and secreted by cholangiocytes) in the regulation of biliary growth/damage by autocrine/paracrine mechanisms. Proliferating cholangiocytes display a neuroendocrine phenotype and secrete and respond to a number of hormones, neuropeptides and neurotransmitters in autocrine and paracrine signaling mechanisms. My research interests also include determining the interactions that occur between cholangiocytes and other cell types (such as hepatocytes, hepatic stellate cells, and vascular endothelial cells) in the biliary microenvironment during both cholestasis and cholangiocarcinogenesis. My program evaluates the various signaling mechanisms regulating the balance between biliary growth/damage. I have expertise in the areas of ...
Chronic inflammation and allergy involve the activation of tissue-resident cells and, later on, the invasion of effector cells. We have previously shown that the loss of phosphoinositide 3-kinase (PI3K) γ impairs chemokine-dependent migration of neutrophils and macrophages both in vitro and in vivo. On the other hand, PI3Kγ is not required either during phagocytic processes or in the activation of bactericidal activities like granule secretion and particle-mediated respiratory burst in neutrophils. Tissue mast cells are key regulators in allergy and inflammation and release histamine upon clustering of their IgE receptors. We have demonstrated that murine mast cell responses are exacerbated in vitro and in vivo by autocrine signals, and require functional PI3Kγ. Adenosine, acting through the A3 adenosine receptor, as well as other agonists of Gαi-coupled receptors, transiently increased PtdIns(3,4,5)P3 exclusively via PI3Kγ. PI3Kγ-derived PtdIns(3,4,5)P3 was instrumental for initiation of ...
Fingerprint Dive into the research topics of Autocrine-paracrine inhibition of growth hormone and prolactin production by GH,sub,3,/sub, cell-conditioned medium. Together they form a unique fingerprint. ...
Amphiregulin (AR) is a newly discovered glycosylated, 84-amino acid residue polypeptide growth regulator which has sequence homology to the EGF family of proteins. To obtain immunological reagents to study the biological role of AR, two synthetic peptides containing sequences corresponding to distinct regions of AR were used to generate polyclonal antibodies in rabbits. One preparation of antipeptide antibodies directed against residues 26-44 of AR (AR-Ab2) was most effective in the detection of native AR, whereas another preparation of antibodies against residues 8-26 (AR-Ab1) was found to be most efficacious in the detection of AR in formalin-fixed and paraffin-embedded tissues. The growth of a colon carcinoma cell line, Geo, which proliferates autonomously under serum-free conditions, was stimulated by the exogenous addition of AR or EGF. Half-maximal stimulation of this growth was observed at 40 and 200 pM of EGF and AR, respectively. A mAb to the extracellular domain of the EGF receptor ...
Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell. This can be contrasted with paracrine signaling, intracrine signaling, or classical endocrine signaling. An example of an autocrine agent is the cytokine interleukin-1 in monocytes. When interleukin-1 is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it.[citation needed] Another example occurs in activated T cell lymphocytes, i.e., when a T cell is induced to mature by binding to a peptide:MHC complex on a professional antigen-presenting cell and by the B7:CD28 costimulatory signal. Upon activation, low-affinity IL-2 receptors are replaced by high-affinity IL-2 receptors consisting of α, β, and γ chains. The cell then releases IL-2, which binds to its own new IL-2 receptors, causing self-stimulation and ...
Purified anti-human/mouse IL-21 Antibody - Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses.  These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells.  It can also be proapoptotic for B cells and NK cells.  Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases..
Purified anti-human/mouse IL-21 Antibody - Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses.  These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells.  It can also be proapoptotic for B cells and NK cells.  Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases..
Lytic CD8+ T cells at the psoriasis plaques epidermis secrete IL‐17, IL‐21 and IL‐22 and depends on autocrine TNFalpha production. IL‐17‐producing CD4+ T ...
Takaoka et al. have presented persuasive evidence that in MEFs the IFN-γ response is substantially augmented through autocrine IFN-α/β and that cross-recruitment and phosphorylation of the IFNAR1 subunit of the IFN-α/β receptor occurs in response to IFN-γ in these cells (24). We have been unable to obtain evidence for or against recruitment or phosphorylation of IFNAR1 in response to IFN-γ in the HT1080-based human cell systems used here (H. Isharc and I. M. Kerr, unpublished data). In a potentially analogous but inverse situation, cross-phosphorylation of the IFNGR1 subunit of the IFN-γ receptor in response to activation of erythropoietin/gp130 receptor chimeras in HT1080-based cell lines is observed. Importantly, however, such receptor cross-phosphorylation plays no part in the IFN-γ-like response observed (23), a result which emphasizes that even if IFNAR1 were recruited and phosphorylated in response to IFN-γ, proof of necessity of this for the IFN-γ antiviral response would ...
Despite the considerable improvements in our knowledge of AML biology in recent years, the treatment of this disease remains a challenge for clinicians. Major efforts have been made to develop new compounds that target the preferentially activated signaling pathways implicated in AML cell proliferation and survival. The PI3K/Akt/mTOR axis represents a promising therapeutic target in several cancers, as many components of these signaling pathways are frequently deregulated in tumor cells. We recently showed that a constitutive activation of PI3K is detected in ∼50% of primary AML samples at diagnosis(8), mostly due to an autocrine stimulation of the IGF-1 receptor (9). Accordingly, either the blockade of this IGF-1 autocrine production or the specific inhibition of PI3K p110δ activity leads to a strong decrease of AML cell proliferation (4, 5, 9). The constitutive activation of the mTORC1 pathway is detectable in virtually almost all AML patient samples, which emphasized the potential of using ...
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For several years there has been considerable interest in stimulating angiogenesis by a variety of growth factors, including the family of fibroblast growth factors (FGF). FGF-5 is a protooncogene known to stimulate cell growth and proliferation in multiple cell types, including cancer.1 The cardiac myocyte can also produce different isoforms of FGFs, eg, it has been shown that the expression of basic FGF increases in hibernating myocardium,2 which was the disease state of interest in the current study published in Circulation Research.3 The most commonly cited effect of FGF-5 in the heart is to promote angiogenesis. Several studies have shown that gene transfer of FGF-5 in the heart increases vessel formation and regional blood flow.4-6 This effect is mediated by a production of FGF-5 by the cardiac myocytes, followed by its release in the extracellular space. In addition, FGF-5 can function as an autocrine/paracrine mechanism of cardiac cell growth and as a cytoprotective mechanism against ...
Lipoxygenases (EC 1.13.11.-) are a family of (non-heme), iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells. The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives. Lipoxygenases are found in eukaryotes (plants, fungi, animals, protists); while the third domain of terrestrial life, the archaea, ...
Phlogistic reactions, whether of extraocular or intraocular origin, tend to be down regulated by the avascular, and hence immune privileged, cornea. And this feature is recognised as being essential for a favourable graft prognosis. In situ, corneal tissue is protected from potential inflammatory stimulants, such as endotoxins, by the epithelial and vascular barriers; but in vitro, the situation is different. Under these conditions, contamination of culture media with endotoxins could have untoward effects; these may be manifested either directly, by overt changes in cell morphology, and/or by a more discreet influence on the tissues immunological status, the consequences of which may be realised only after transplantation, by a compromised graft performance.. In the current study, we monitored the media of organ cultured corneas for a number of cytokine mediators of the inflammatory response, both before and after spiking with endotoxin; these data were then compared with those pertaining to ...
article{99c2b32e-f9cf-4afb-8052-6d71d776ad00, abstract = {The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.}, author = {Sitnicka Quinn, Ewa and Bryder, David and Theilgaard-Mönch, Kim and Buza-Vidas, Natalija and Adolfsson, Jörgen and Jacobsen, Sten Eirik W}, issn = ...
Our hypothesis is based on several lines of evidence. First, the effects of cAMP and DA on both 4xCRE (Figs. 3a,b, 5) and c-fos and BDNF mRNA expression (Fig. 6) are blocked by NMDAR antagonists. Second, two structurally distinct inhibitors of neuronal EAA uptake, TBOA (Fig. 7) and trans-PDC (supplemental Fig. S3, available at www.jneurosci.org as supplemental material), potentiated the stimulation of gene transcription by cAMP. Third, the aspartate+glutamate-, but not the glutamate-only-, scavenging system abolished stimulation of CREB-dependent gene transcription by forskolin (Fig. 8); the aspartate-scavenging enzyme, GOT, degrades l- but not d-aspartate demonstrating that l-aspartate is the active extracellular EAA in this signaling pathway. Finally, forskolin was found to induce release of aspartate but not glutamate (Fig. 9). Together, these results lead to the conclusion that cAMP-induced release of aspartate and the resulting activation of NR2B-containing NMDARs mediate the effects of ...
Looking for online definition of autocrine in the Medical Dictionary? autocrine explanation free. What is autocrine? Meaning of autocrine medical term. What does autocrine mean?
1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90 2. Bosetti C, Turati F, La Vecchia C. Hepatocellular carcinoma epidemiology. Best Pract Res Clin Gastroenterol. 2014;28:753-770 3. Li S, Sun R, Chen Y, Wei H, Tian Z. TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression. Cancer Res. 2015;75:986-995 4. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007;317:121-124 5. He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013;155:384-396 6. Gu FM, Li QL, Gao Q, Jiang JH, Zhu K, Huang XY, Pan JF, Yan J, ...
Epithelial branching morphogenesis drives the development of organs such as the lung, salivary gland, kidney and the mammary gland. It involves cell proliferation, cell differentiation and cell migration. An elaborate network of chemical and mechanical signals between the epithelium and the surrounding mesenchymal tissues regulates the formation and growth of branching organs. Surprisingly, when cultured in isolation from mesenchymal tissues, many epithelial tissues retain the ability to exhibit branching morphogenesis even in the absence of proliferation. In this work, we propose a simple, experimentally plausible mechanism that can drive branching morphogenesis in the absence of proliferation and cross-talk with the surrounding mesenchymal tissue. The assumptions of our mathematical model derive from in vitro observations of the behaviour of mammary epithelial cells. These data show that autocrine secretion of the growth factor TGFβ1 inhibits the formation of cell protrusions, leading to ...
The growing knowledge behind the mechanism of autocrine signaling in cancer progression has revealed new approaches for therapeutic treatment. For example, autocrine Wnt signaling could provide a novel target for therapeutic intervention by means of Wnt antagonists or other molecules that interfere with ligand-receptor interactions of the Wnt pathway.[2][3] In addition, VEGF-A production and VEGFR-2 activation on the surface of breast cancer cells indicates the presence of a distinct autocrine signaling loop that enables breast cancer cells to promote their own growth and survival by phosphorylation and activation of VEGFR-2. This autocrine loop is another example of an attractive therapeutic target.[8]. In HER2 overexpressing breast cancers, the HER2-IL-6-STAT3 signaling relationship could be targeted to develop new therapeutic strategies.[6] HER2 kinase inhibitors, such as lapatinib, have also demonstrated clinical efficacy in HER2 overexpressing breast cancers by disrupting a neuregulin-1 ...
Nitric oxide-generating system as an autocrine mechanism in human polymorphonuclear leucocytes.: Recent data [Lopéz-Farré, Riesco, Moliz, Egido, Casado, Hernand
Programmed cell death has a vital role in embryonic development and tissue homeostasis. oxygen varieties (ROS) in tuberculosis illness. Experimental studies have also demonstrated that upregulation of RIPK3 and MLKL detected in alcoholic and drug-induced liver injury suggests that necroptosis is also involved in sterile inflammation. Application of Necrostatin (Nec)-1 or depletion of RIPK3 protects liver cells from these types of injuries [74]. Parasitic diseases like leishmaniasis and malaria generally caused hemolysis, Lenalidomide supplier anemia, and sometimes bleeding. These result due to rupturing of red blood corpuscles (RBCs) leading to release of hemoglobin (Hb) into circulation; heme is produced on oxidation of Hb leading to initiation of the Fenton reaction and culminates with generation of ROS. Heme is also responsible for direct activation of TLR4, leading to autocrine secretion of ROS and TNF, and they activate the RIPK1/3-dependent necroptosis in a synergistic manner [75]. In ...
Gonadotropin-releasing hormone (GnRH) is a decapeptide hormone secreted by GnRH neurons located in the hypothalamus. It is responsible for the onset of puberty and the regulation of hormone release from the pituitary. There is a strong evidence suggesting that these GnRH neurons are intrinsically capable of generating pulsatile and episodic neurosecretion of this hormone. However, the underlying mechanism for the GnRH-pulse generator remains obscure. The discovery of GnRH receptors allowing GnRH to exert autocrine regulation on its own release, led several experimentalist in NIH to propose in 2003 a mechanism underlying this effect. We developed in 2006 a mathematical model describing the proposed mechanism, then we extended it to explain synchrony observed in GnRH neurons by incorporating the idea of a common pool of GnRH hormone. In this talk, we shall present this model and analyze several aspects of it, especially robustness. We shall show that the coupling of a heterogeneous family of GnRH ...
2390 Janus kinase 2 (JAK2) is a cytokine receptor associated tyrosine kinase. Binding of cytokines to their specific receptors leads to their dimerization and activation of associated JAKs. Activated JAKs phosphorylate specific tyrosine residues in the cytoplasmic chains of the receptor, which now act as docking sites for SH2 containing latent transcription factors known as STATs. Once bound to the receptor, STATs are activated by JAKs through phosphorylation of their tyrosine residues. Activated STATs form stable dimers and translocate to the nucleus, where they bind specific promoter sequences of their target genes involved in cell proliferation and survival, such as Bcl-xL, Bcl-2, c-myc and cyclin D1. Tumor cell lines and samples derived from hematopoetic malignancies (leukemia, lymphoma and multiple myeloma) and solid tumors (breast, head and neck, lung, prostrate and ovarian cancers) exhibit deregulated JAK-STAT signaling, which can be attributed to autocrine cytokine production or growth ...
NovoPro offers a wide selection of tools for research on cytokines and their receptors. These include high-purity recombinant proteins, high-specific antibodies and ORF cDNA clones.. Cytokines are a large group of proteins, peptides or glycoproteins that are secreted by specific cells of immune system. Cytokines are a category of signaling molecules that mediate and regulate immunity, inflammation and hematopoiesis. Cytokines are produced throughout the body by cells of diverse embryological origin. Cytokine is a general name; other names are defined based on their presumed function, cell of secretion, or target of action. For example, cytokines made by lymphocytes can also be referred to as lymphokines, while interleukins are made by one leukocyte and act on other leukocytes. And chemokines are cytokines with chemotactic activities.. Cytokines may act on the cells that secrete them (autocrine action), on nearby cells (paracrine action), or in some instances on distant cells (endocrine ...
Autocrine hypothesis definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
VEGF-A promoted DJM-1 cell proliferation via NRP1 in an autocrine manner. (A) A western blot shows that DJM-1 cells expressed NRP1, but not NRP2. DJM-1 cells we
Comoglio, P.M., 1988: Autocrine activation of the tyrosine kinase associated with the bombesin receptor in small cell lung carcinoma
Dictyostelium cells secrete the proteins AprA and CfaD. Cells lacking either AprA or CfaD proliferate faster than wild type, while AprA or CfaD overexpressor cells proliferate slowly, indicating that AprA and CfaD are autocrine factors that repress proliferation. CfaD interacts with AprA and requires the presence of AprA to slow proliferation. To determine if CfaD is necessary for the ability of AprA to slow proliferation, whether AprA binds to cells, and if so whether the binding requires the presence of CfaD, we examined the binding and effect on proliferation of recombinant AprA. We find that the extracellular accumulation of AprA increases with cell density and reaches a concentration of 0.3 μg/ml near a stationary cell density. When added to wild-type or aprA- cells, recombinant AprA (rAprA) significantly slows proliferation at 0.1 μg/ml and higher concentrations. From 4 to 64 μg/ml, the effect of rAprA is at a plateau, slowing but not stopping proliferation. The proliferation-inhibiting
alpha(1B)-Adrenergic receptors mediate many of the actions of the natural catecholamines, adrenaline and noradrenaline. They belong to the seven transmembrane domains G protein-coupled receptor superfamily and exert their actions mainly through activation of Gq proteins and phosphoinositide turnover/calcium signaling. Many hormones and neurotransmitters are capable of inducing alpha(1B)-adrenergic receptor phosphorylation and desensitization; among them: adrenaline and noradrenaline, phorbol esters, endothelin-I, bradykinin, lysophosphatidic acid, insulin, EGF, PDGF, IGF-I, TGF-beta, and estrogens. Key protein kinases for these effects are G protein coupled receptor kinases and protein kinase C. The lipid/protein kinase, phosphoinositide-3 kinase also appears to play a key role, acting upstream of protein kinase C. In addition to the agents employed for cells stimulation, we observed that paracrine/autocrine mediators also participate; these processes include EGF transactivation and ...
As potential autocrine or paracrine factors, extracellular nucleotides are known to be important regulators of renal ion transporters by activating cell surface receptors and intracellular signaling pathways. We investigated the influence of extracellular adenine nucleotides on Na+/H+ exchanger isoform 3 (NHE3) activity in A6-NHE3 cells. This is a polarized cell line obtained by stable transfection of A6 cells with the cDNA encoding the rat isoform of NHE3, which is expressed on the apical membrane. Basolateral addition of the P2Y(1) agonist, 2-Me-SADP, induced an inhibition of NHE3 activity, which was prevented by preincubation with selective P2Y(1) antagonists, MRS 2179 (N-6-methyl-2-deoxyadenosine-3,5-bisphosphate) and MRS 2286 (2-[2-(2-chloro-6-methylamino-purin-9-yl)-ethyl]-propane- 1,3-bisoxy(diammoniumphosphate)). NHE3 activity was also significantly inhibited by ATP and ATP-gamma-S but not by UTP. 2-Me-SADP induced a P2Y(1) antagonist-sensitive increase in both [Ca2+]i and cAMP ...
The RAF inhibitor vemurafenib (PLX4032) increases survival in patients with BRAF-mutant metastatic melanoma, but has limited efficacy in patients with colorectal cancers. Thyroid cancer cells are also comparatively refractory to RAF inhibitors. By contrast to melanomas, inhibition of MAPK signaling by vemurafenib is transient in thyroid and colorectal cancer cells. The rebound in ERK in thyroid cells is accompanied by increased HER3 signaling caused by induction of HER3 transcription through decreased promoter occupancy by the transcriptional repressors CtBP1 and 2, and by autocrine secretion of neuregulin-1. The HER kinase inhibitor lapatinib prevents MAPK rebound and sensitizes BRAF-mutant thyroid cancer cells to RAF or MEK inhibitors. This provides a rationale for combining ERK pathway antagonists with inhibitors of feedback-reactivated HER signaling in this disease. The determinants of primary resistance to MAPK inhibitors vary between cancer types, due to preferential upregulation of ...
Eosinophils are major effector cells in type 2 inflammatory responses and become activated in response to IL-4 and IL-33, yet the molecular mechanism remains unclear. We examined the direct effect of these cytokines on eosinophils and demonstrated that murine eosinophils respond to IL-4 and IL-33 by phosphorylation of STAT-6 and NFkB, respectively. RNA sequencing analysis of murine eosinophils indicated that IL-33 regulates 519 genes, whereas IL-4 regulates only 28 genes, including 19 IL-33-regulated genes. Interestingly, IL-33 induced eosinophil activation via two distinct mechanisms, IL-4 independent and IL-4 secretion/auto-stimulation dependent. Anti-IL-4 or anti-IL-4Ra antibody-treated eosinophils, as well as Il4- or Stat6-deficient eosinophils, had attenuated protein secretion of a subset of IL-33-induced genes, including Retnla and Ccl17. However, the induction of most IL-33-regulated transcripts (e.g. Il6 and Il13) was IL-4 independent and blocked by NFkB inhibition. Indeed, IL-33 induced the
Th17 cells are critically involved in autoimmune disease induction and severity. Recently, we showed that Th17 cells from patients with rheumatoid arthritis (RA) directly induced a proinflammatory loop upon interaction with RA synovial fibroblasts (RASF), including increased autocrine IL-17A production. To unravel the mechanism driving this IL-17A production, we obtained primary CD4+CD45RO+CCR6+ (Th17) cells and CD4+CD45RO+CCR6− (CCR6−) T cells from RA patients or healthy individuals and cocultured these with RASF. IL-1β, IL-6, IL-23p19, and cyclooxygenase (COX)-2 expression and PGE2 production in Th17-RASF cultures were higher than in CCR6− T cell-RASF cultures. Cytokine neutralization showed that IL-1β and IL-6, but not IL-23, contributed to autocrine IL-17A induction. Importantly, treatment with celecoxib, a COX-2 inhibitor, resulted in significantly lower PGE2 and IL-17A, but not IFN-γ, production. Combined celecoxib and TNF-α blockade more effectively suppressed the ...
Epithelial cells are unable to grow or survive when they lose contact with appropriate ECM proteins. However, transformation by the Ras oncoprotein bypasses the need for signals from adhesion receptors and protects them from undergoing apoptosis. Ras‐dependent survival in other systems is known to have two effectors, PI 3‐K and Raf, the latter of which functions by activating the ERK (a MAPK) pathway. To address the contribution of ERK, J. Downward (London, UK) used an inducible active form of Raf to monitor early changes in gene transcription that impart protection from detachment‐induced apoptosis. Among the genes that are strongly up‐regulated by activated Raf are the autocrine factors HB‐EGF, amphiregulin and TGFα. All of these are members of the epithelial growth factor (EGF) family, indicating that protection by Raf is dependent on the function of an autocrine loop involving transcriptional induction of cell survival EGF‐like factors. Interestingly, Raf‐dependent survival is ...
In light of the poor control of malignant mesothelioma by approved cytotoxic chemotherapeutic regimens, RTKs have been actively explored in MPM as alternative therapeutic targets (15, 19, 42, 43). Although EGFR, VEGFRs, MET, and PDGFRs have been a focus in these studies, our findings support the novel role of FGFR1 as a growth driver in a subset of MPM cell lines and suggest that FGFR-active TKIs may serve as therapeutics in this cancer. RNAi-mediated silencing of FGFR1 inhibited clonogenic growth of two FGFR1-expressing MPM cell lines, H226 and MSTO211H (Fig. 4), and the TKI, ponatinib, selectively inhibited growth of MPM cell lines expressing FGFR1 (Fig. 2). We previously demonstrated with RNAi-mediated silencing the requirement of FGF2 for H226 cell growth (35), and we validate this finding by showing sensitivity of FGFR1-dependent mesothelioma cell lines to the ligand trap, FP-1039. Combined, the data support the activity of an FGF-FGFR1 autocrine pathway in a subset of mesothelioma cell ...
PMID 19356622.CS1 maint: multiple names: authors list (link) Sugar I.P., Sealfon S.C. (2009). "Model of autocrine/paracrine ... signaling in epithelial layer: geometrical regulation of intercellular communication". J Phys Chem B. 113 (31): 10946-56. doi: ...
... s use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are ... In Wnt signaling, these proteins act as ligands to activate the different Wnt pathways via paracrine and autocrine routes. ... Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.Int. J. Cancer ... January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5 ...
Autocrine purinergic signalling is an important checkpoint in the activation of white blood cells. These mechanisms either ... It has an excitatory effect on neurones, and acts as a mediator in neuronal-glial communications. Both adenosine and ATP induce ... The release of ATP and an autocrine feedback through P2RY2 and A3 receptors are signal amplifiers. Hypoxia-inducible factors ... Although purinergic signaling has been connected to pathological processes in the context of neuron-glia communication, it has ...
Endocrine, paracrine, and autocrine signaling pathways that regulate ovulation. Trends Endocrinol. Metab. 29:313-325. NCBI - ... Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle. Ann. Rev. Physiol. 79:237- ... Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle. Ann. Rev. Physiol. 79:237- ...
"Cell-to-cell communication in the anterior pituitary: evidence for gap junction-mediated exchanges between endocrine cells and ... autocrine/paracrine control of anterior pituitary cell function though the use of cytokines and growth factors, intrapituitary ... as the IL-6 is a mediator in communication between the endocrine and immune system. IL-6 production by FS cells induces hormone ... A route for long-distance communication in the anterior pituitary". Proceedings of the National Academy of Sciences. 98 (15): ...
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine ... Autocrine+signaling at the US National Library of Medicine Medical Subject Headings (MeSH) "Autocrine versus juxtacrine ... and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR ...
2002). "General Principles of Cell Communication". In NCBI bookshelf (ed.). Molecular biology of the cell (4th ed.). New York: ... Other types of cell signaling include paracrine signalling and autocrine signalling. The term "juxtacrine" was originally ... "Autocrine versus juxtacrine signaling modes" - illustration at sysbio.org. ... cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. This signaling can influence the cell ...
2003). "Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding ... Biochemical and Biophysical Research Communications. 288 (4): 1043-1046. doi:10.1006/bbrc.2001.5869. PMID 11689016. Mouta ...
Recently, co-culture has become the predominant approach to study the effect of cellular communication by culturing two ... autocrine signaling, and juxtacrine signaling. For example, in paracrine signaling, growth factors secreted from one cell ... Bogdanowicz DR, Lu HH (April 2013). "Studying cell-cell communication in co-culture". Biotechnology Journal. 8 (4): 395-6. doi: ... cells can engage in enhanced communication with neighboring cells and cell-extracellular matrix interactions can be modeled. In ...
These growth factors often act in a paracrine or autocrine fashion; they include fibroblast growth factor, placental growth ... requiring precise coordination of multiple steps and the participation and communication of multiple cell types. The complex ...
Choy L, Skillington J, Derynck R (May 2000). "Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte ... Nature Communications. 10 (1): 2757. doi:10.1038/s41467-019-10688-x. PMC 6588633. PMID 31227697.. ...
2001-12-15). "Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells". Cancer Research. 61 ( ... Biochemical and Biophysical Research Communications. 320 (2): 493-500. doi:10.1016/j.bbrc.2004.06.003. PMID 15219856. Miyashita ...
Autocrine[edit]. Main article: Autocrine signalling. Autocrine signaling is a form of signaling in which a cell secretes a ... Juxtacrine signaling is a type of intercellular communication that is transmitted via oligosaccharide, lipid, or protein ... Endocrine, paracrine, and autocrine signaling have all been implicated in proliferation, one of the required steps of ... The term hormone is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or ...
2016: Autocrine secretion of hPG80 promotes survival and self-renewal of stem cells in colon cancer. 2017: The use of ... Biochemical and Biophysical Research Communications. 336 (1): 190-196. doi:10.1016/j.bbrc.2005.08.061. ISSN 0006-291X. PMID ... These observations led to the study of autocrine and paracrine function of hPG80 in tumor cells. Generally, it has been shown ... "Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells". Cancer Research. 76 ...
Takagi, Y.; Fukase, M.; Takata, S.; Yoshimi, H.; Tokunaga, O.; Fujita, T. (1990-04-30) «Autocrine effect of endothelin on DNA ... synthesis in human vascular endothelial cells» Biochemical and Biophysical Research Communications (2): 537-543 ISSN 0006-291X ...
Hoyos E, Kim K, Milloz J, Barkoulas M, Pénigault JB, Munro E, Félix MA (April 2011). "Quantitative variation in autocrine ... Nature Communications. 10 (1): 2418. Bibcode:2019NatCo..10.2418X. doi:10.1038/s41467-019-10388-6. PMC 6546794. PMID 31160574. ...
Communication between endothelial cells and pericytes is vital. Inhibiting the PDGF pathway leads to pericyte deficiency. This ... "Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression". Blood. 118 ( ... The apoptosis of pericytes in the aging brain may be the result of a failure in communication between growth factors and ... Endothelial cells and pericytes are interdependent and failure of proper communication between the two cell types can lead to ...
Inhibition of cytokine receptor synthesis and blockade of the autocrine and paracrine actions of cytokines and PGE2 were also ... Biochemical and Biophysical Research Communications. 261 (1): 214-217. doi:10.1006/bbrc.1999.1010. PMID 10405348. Cheng, Z. N ...
Her work on cell-to-cell communication has also focused on the mechanisms that determine organ size and shape. In September ... Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling. eLife: e24102 ... Torii researches stem cell maintenance and the cell-to-cell communication required to correctly pattern tissue during ...
Kelley used these data to strongly advance the concept of communication networks between the brain and the immune system. This ... Prolactin synthesized and secreted by human peripheral blood mononuclear cells: An autocrine growth factor for ... He is considered as an international authority on reciprocal communication systems between the immune system and brain. His ... In his research, he used two approaches to prove the existence of important neuroendocrine-immune communication systems: ...
Nature Communications. 11 (3570): 3570. Bibcode:2020NatCo..11.3570T. doi:10.1038/s41467-020-17312-3. PMC 7366647. PMID 32678081 ... dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition". Biochimica et Biophysica Acta ...
LMW FGF2 is primarily cytoplasmic and functions in an autocrine manner, whereas HMW FGF2s are nuclear and exert activities ... Biochemical and Biophysical Research Communications. 261 (3): 756-65. doi:10.1006/bbrc.1999.1039. PMID 10441498. Kirikoshi H, ... Biochemical and Biophysical Research Communications. 274 (2): 337-43. doi:10.1006/bbrc.2000.3142. PMID 10913340. Potthoff MJ, ...
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine ... and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR ... Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors.[ ...
Islets can influence each other through paracrine and autocrine communication, and beta cells are coupled electrically to six ...
They have autocrine, paracrine and/or endocrine effects; their systemic effects occur at picomolar concentrations. Receptors ... Biochemical and Biophysical Research Communications. 450 (2): 1089-94. doi:10.1016/j.bbrc.2014.06.123. PMID 24996176. Boström P ... Indeed, muscle-produced IL-6 after repeated contractions also has important autocrine and paracrine benefits, acting as a ... Biochemical and Biophysical Research Communications. 450 (2): 1089-94. doi:10.1016/j.bbrc.2014.06.123. PMID 24996176. Gomez- ...
They have also recently been found to play a role in cell-to-cell communication.[7] ... "The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell ... suggestive of a role in intercellular communication". Proceedings of the National Academy of Sciences of the United States of ... Biochemical and Biophysical Research Communications. 295 (3): 663-7. doi:10.1016/s0006-291x(02)00727-1. PMID 12099690.. ...
Gastric-brain communication is an essential part of energy homeostasis, and several communication pathways are probable, ... autocrine modulators in health and disease". Clinical and Experimental Pharmacology & Physiology. 37 (1): 125-31. doi:10.1111/j ... Biochemical and Biophysical Research Communications. 374 (1): 60-63. doi:10.1016/j.bbrc.2008.06.114. PMID 18611393.. ... Biochemical and Biophysical Research Communications. 280 (1): 132-38. doi:10.1006/bbrc.2000.4065. PMID 11162489.. ...
This definition holds for most "classical" hormones, but there are also paracrine mechanisms (chemical communication between ... cells within a tissue or organ), autocrine signals (a chemical that acts on the same cell), and intracrine signals (a chemical ...
These attributes make nitric oxide ideal for a transient paracrine (between adjacent cells) and autocrine (within a single cell ... Nature Communications. 10 (1): 4020. Bibcode:2019NatCo..10.4020H. doi:10.1038/s41467-019-12045-4. PMC 6728379. PMID 31488841. ... It can have endocrine, paracrine, and autocrine effects. In their endocrine mode of action, for example, gasotransmitters can ... Biochemical and Biophysical Research Communications. 157 (1): 87-94. doi:10.1016/S0006-291X(88)80015-9. PMID 3196352. Janeway, ...
Nature Communications. 11 (205): 205. Bibcode:2020NatCo..11..205S. doi:10.1038/s41467-019-13882-z. PMC 6954273. PMID 31924764. ... are mediated through either intracrine or autocrine mechanisms, indicating that the cells releasing these hormones are ...
The autocrine or paracrine secretion of IL-2 can bind to that same Th cell or neighboring Th's via the IL-2R thus driving ... B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A ... which acts upon itself in an autocrine fashion. Activated T cells also produce the alpha sub-unit of the IL-2 receptor (CD25 or ...
... these arachidonic acid metabolites act locally as Autocrine signalling and/or Paracrine signaling agents to regulate the ... Biochemical and Biophysical Research Communications. 420 (2): 428-33. doi:10.1016/j.bbrc.2012.03.012. PMID 22426480. Lee, J. W ... Biochemical and Biophysical Research Communications. 261 (1): 218-23. doi:10.1006/bbrc.1999.1012. PMID 10405349. Ding, X. Z.; ... Biochemical and Biophysical Research Communications. 296 (4): 942-8. doi:10.1016/s0006-291x(02)02014-4. PMID 12200139. Vonach, ...
Depending on the types of purinergic receptors that are involved, autocrine signalling can promote or inhibit cell activation ... Stimulation of almost all mammalian cell types leads to the release of cellular ATP and autocrine feedback through a diverse ... Autocrine Communication / physiology* * Chemotaxis / physiology * Humans * Immune Tolerance / physiology * Immunity, Innate / ... Immune cell regulation by autocrine purinergic signalling Nat Rev Immunol. 2011 Mar;11(3):201-12. doi: 10.1038/nri2938. Epub ...
Autocrine Communication* / drug effects * Autocrine Communication* / genetics * Cell Line, Tumor * Cell Proliferation / drug ... Autocrine Activation of the MET Receptor Tyrosine Kinase in Acute Myeloid Leukemia Nat Med. 2012 Jul;18(7):1118-22. doi: ... Our results show a widespread dependence of AML cells on autocrine activation of MET, as well as the key role of compensatory ... We found HGF expression leading to autocrine activation of its receptor tyrosine kinase, MET, in nearly half of the AML cell ...
PMID 19356622.CS1 maint: multiple names: authors list (link) Sugar I.P., Sealfon S.C. (2009). "Model of autocrine/paracrine ... signaling in epithelial layer: geometrical regulation of intercellular communication". J Phys Chem B. 113 (31): 10946-56. doi: ...
Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are ... In Wnt signaling, these proteins act as ligands to activate the different Wnt pathways via paracrine and autocrine routes. ... Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.Int. J. Cancer ... January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5 ...
... personal communication). Similarly, an activating Tie-2 mutation causes venous malformations that are composed of dilated ... Moreover, the data identify Ang-2 as a rapid autocrine regulator of vascular stability that acts through an internal autocrine ... However, autocrine Ang-2-mediated endothelial-cell detachment cannot be blocked by soluble Tie-2. Taken together, the data ... Keating, M. T. and Williams, L. T. (1988). Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. ...
Autocrine peptide signals, self-organization and zombie cells: molecular... ... Communication officer. Umeå Plant Science Centre. Email: [email protected] Phone: +46 70 285 6657 ... Autocrine peptide signals, self-organization and zombie cells: molecular switches in phloem formation. Host: Ove Nilsson. Place ... Seminar - Christian S. Hardtke: Autocrine peptide signals, self-organization and zombie cells: molecular switches in phloem ...
Biochemical and Biophysical Research Communications, 260: 775-780. [ Links ]. 33. Litvak DA, Evers BM, Hwang KO, Hellmich MR, ... Butyrate induces apoptosis in murine macrophages via caspase-3, but independent of autocrine synthesis of tumor necrosis factor ... g and autocrine synthesis of TNF-. a and NO.. The physiologic onset of apoptosis is strictly regulated by ligand receptor ... Biochemical and Biophysical Research Communications, 246: 760-764. [ Links ]. 36. Bauer WR, Hates JJ, White JH & Wolffe AP ( ...
The stomatal precursor cell uses autocrine peptide-receptor kinase signaling to self-inhibit its differentiation potential in ... Stomatal development: a plants perspective on cell polarity, cell fate transitions and intercellular communication * OS Lau ... B) Autocrine signaling model: Facette and Smith (2012) proposed an alternate, autocrine signaling model based on the ... triggers autocrine inhibition of stomatal fate. During normal stomatal development, this autocrine inhibition prevents extra ...
Its growth goes from endocrine stimulated to juxtocrine, paracrine, autocrine. Ion communication ports between cells close, ... They are now autocrine in their regulation (regulate themselves) having begun when first transformed as endocrine e.g. ... Please make a tax-deductible donation if you value independent science communication, collaboration, participation, and open ... estradiol from the ovary, then juxstacrine (nearby) paracrine (next door) then autocrine. The exoskeleton by which its cells ...
Nature Communications (2020) * Amplification of autocrine motility factor and its receptor in multiple myeloma and other ... The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett. 456, 295-300 (1999 ... Nabi, I.R., Watanabe, H. & Raz, A. Identification of B16-F1 melanoma autocrine motility-like factor receptor. Cancer Res. 50, ... Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J. Biol. Chem. 266, 13442- ...
... and autocrine signals. Although many of the factors involved in... ... Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science 2002; 296:2178-80.PubMedCrossRef ... Tesone M., Abramovich D., Irusta G., Parborell F. (2009) Autocrine and Paracrine Regulation of the Ovary. In: Chedrese P. (eds ... Involvement of nerve growth factor in the ovulatory cascade: trkA receptor activation inhibits gap junctional communication ...
Real-Time Cell Analysis (RTCA) assays were performed to assess whether AMF depends on Autocrine motility factor recepter (AMFR ... Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of ... Cell Communication and Signaling volume 17, Article number: 22 (2019) Cite this article ... Li, Y., Jia, Y., Bian, Y. et al. Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1. Cell ...
In the current communication, we demonstrated a novel crosstalk between NK cells and eosinophils via IL-15/IL-8 axis. This may ... These results indicate a novel autocrine activity for NK cells in recruiting eosinophils and highlight a novel role for IL-15 ... Modulation of NK Cell Autocrine-Induced Eosinophil Chemotaxis by Interleukin-15 and Vitamin D3: A Possible NK-Eosinophil ... R. Hoontrakoon, H. C. Chu, J. Gardai et al., "Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine ...
communication between two attached celsl. juxtacrine. communication the cell talks to itself. autocrine. ... communication between distant cells. neuroendocrine. Five stages of cellular migration into an inflamed tissue. 1 margination 2 ... Communication between two adjacent cells. gap junctions. ... communication between distant cells endocrine. communication at ...
Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling. J. Biol. Chem. 289, 26794- ...
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine ... Autocrine signaling at the US National Library of Medicine Medical Subject Headings (MeSH) "Autocrine versus juxtacrine ... and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR ...
YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression. Oncogene, 2015, 34:6040- ... Narrowly regulated cell-cell communication plays critical role in the follicle cell proliferation, differentiation, ... Delineating the paracrine and autocrine regulation of ovarian function. The basic functional unit of the ovary is the follicle ... These findings bolstered our understanding on the mechanisms underlying the endocrine, paracrine and autocrine regulation of ...
Endocrine, neurocrine, paracrine, and autocrine communications). 2. Classification of hormones according to the type of ... analyze the signaling mechanisms engaged in the intracellular and intercellular communication;. - present their extended ...
Autocrine-paracrine mechanisms of vascular myocytes in systemic hypertension. Am J Cardiol. 1987;60:99I-103I. ... Gap junctional communication in excitable tissues: the heart as a paradigm. Prog Biophys Mol Biol. 1994;61:1-35. ... Effect of intracellular injection of calcium and strontium on cell communication in heart. J Physiol.. 1975;250:231-245. ... For investigation of the role of the RAS on the control of cell communication in the ventricle of CM hamsters, gj was measured ...
Autocrine Signaling a cell releases a signal affecting cells that are the same type ...
d. communication. ANS: B Conductivity, not sensory interpretation, homeostasis, or communication, is one of the eight chief ... This action is an example of which of the following signaling types? a. Paracrine b. Autocrine c. Neurohormonal d. Hormonal ANS ... REF: p. 10 7. Which form of cell communication is used to relate to other cells in direct physical contact? a. Cell junction b ... Gap junctions allow for cellular communication between cells. Neither desmosomes nor tight junctions are associated with ...
... of intercellular communication direct communication synaptic communication autocrine communication paracrine communication ... Autocrine communication: chemical signals are released by exocytosis and act on the same cell ... 7/16/2018 4 ENDOCRINE COMMUNICATION endocrine communication: chemical signals, called hormones , are released by exocytosis ... 7/16/2018 3 INTERCELLULAR COMMUNICATION direct communication : ions and small molecules diffuse directly from the cytoplasm of ...
Autocrine purinergic signalling is an important checkpoint in the activation of white blood cells. These mechanisms either ... It has an excitatory effect on neurones, and acts as a mediator in neuronal-glial communications. Both adenosine and ATP induce ... The release of ATP and an autocrine feedback through P2RY2 and A3 receptors are signal amplifiers. Hypoxia-inducible factors ... Corriden, R.; Insel, P. A. (5 January 2010). "Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation". ...
More notably, the transfer of these varied molecules almost invariably plays a critical role in the communication between ... More notably, the transfer of these varied molecules almost invariably plays a critical role in the communication between ... Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. Identification of key cellular ... Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. Identification of key cellular ...
The dimensionless group α must exceed unity to allow for autocrine and juxtacrine signaling to occur. The maximal local ... Schematic representation of communication distances, illustrating the definition of the effective communication distance ζ0.5 ... What is required is a definition of an "effective" communication distance. We can define the effective communication distance ... The effective communication distance ζ0.5 is indicated where the c/Km curve at time τ0.5 drops below unity, which occurs at: 14 ...
2007). Bacterial communications in implant infections: a target for an intelligence war. Int J Artif Organs. 30(9):757-63. ... Balaban, N., & Novick, R.P. (1995). Autocrine regulation of toxin synthesis by Staphylococcus aureus. Proc Natl Acad Sci U S A ... Balaban, N., & Novick, R.P. (1995). Autocrine regulation of toxin synthesis by Staphylococcus aureus. Proc Natl Acad Sci U S A ...
Li J et al. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-ß signaling. ... Chen J et al. CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl ... Fan J et al. Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine ... Turner CJ et al. Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion. ...
Autocrine Communication/physiology*. *Gene Expression/physiology*. *Monocytes/metabolism*. *Transforming Growth Factor beta1/ ... Lister Hill National Center for Biomedical Communications •. U.S.National Library of Medicine National Institute of Health • ... Lister Hill National Center for Biomedical Communications •. U.S.National Library of Medicine National Institute of Health • ... Inhibition of autocrine TGF-β signaling by either SB431542 or anti-TGF-β antibody reduced Smad3 activation and strongly ...
Veterinary Research Communications, vol. 32, no. 1, pp. S131-S134, 2008. View at Publisher · View at Google Scholar · View at ... Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions. Kerry L. Hull1,2 and Steve Harvey3 ... X. Q. Xu, B. S. Emerald, E. L. K. Goh et al., "Gene expression profiling to identify oncogenic determinants of autocrine human ... M. J. Van Den Eijnden and G. J. Strous, "Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling ...
Lister Hill National Center for Biomedical Communications •. U.S.National Library of Medicine National Institute of Health • ... siRNA-based suppression of VEGF expression in a Müller cell line in vitro supports the existence of an autocrine role for VEGF ... Lister Hill National Center for Biomedical Communications •. U.S.National Library of Medicine National Institute of Health • ... siRNA-based suppression of VEGF expression in a Müller cell line in vitro supports the existence of an autocrine role for VEGF ...
  • Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. (frontiersin.org)
  • As key mediators of intercellular communication within the tumor ecosystem, TNTs are the central topic of this article. (frontiersin.org)
  • One important mode of intercellular communication is the release of soluble cyto- and chemokines. (pnas.org)
  • Adenosine triphosphate (ATP) has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles. (mdpi.com)
  • Extracellular vesicles (EVs), such as exosomes and microvesicles, play an important autocrine/paracrine role in intercellular communication. (ovid.com)
  • In the developed organism, intercellular communication coordinates the activities between multiple cell types and makes organism-wide processes such as immune response, growth, and homeostasis. (healthcanal.com)
  • Despite the importance of this process, studies in intercellular communication between specialized cells in higher organisms such as mammals have generally focused on communication between just a few cell types and have been limited in scope to small numbers of ligand-receptor pairs. (healthcanal.com)
  • Q. Hormones are an example of intercellular communication known as _____________ signaling.a. neuralb. (clutchprep.com)
  • Gap junction channels, formed by connexins, allow the direct intercellular communication between adjacent cells. (physiology.org)
  • These stiff, adhesive, trypsin- and RNAse-resistant surface nanofilaments add a new dimension to the current structural knowledge of exosome-mediated intercellular communication. (royalsocietypublishing.org)
  • Exosomes are known to play an important role in intercellular communication by extracellular signalling [ 2 ] and horizontal mRNA/microRNA transfer [ 3 ]. (royalsocietypublishing.org)
  • We discuss how these newly recognized nanofilaments may help in modulating, tethering and transport of exosomes for intercellular communication. (royalsocietypublishing.org)
  • Here, we investigated the involvement of gap junction intercellular communication (GJIC) during anchorage-independent clustering of MCF7 breast adenocarcinoma cells. (biomedcentral.com)
  • Loss of gap junction intercellular communication is critical for tumor progression because it allows the tumor cells to escape growth control, invade, and metastasize. (aacrjournals.org)
  • Ovarian follicular development and regression is a continuous and cyclic process that depends on a number of endocrine, paracrine, and autocrine signals. (springer.com)
  • These findings bolstered our understanding on the mechanisms underlying the endocrine, paracrine and autocrine regulation of ovarian physiology. (massgeneral.org)
  • Proteins expressed and released by muscle that have autocrine, paracrine, and endocrine bioactivities have been termed myokines. (frontiersin.org)
  • These myokines are involved in autocrine regulation of metabolism in the muscle itself and paracrine/endocrine regulation of other tissues and organs such as the liver, adipose, and brain. (frontiersin.org)
  • Decide which of the following forms of human communication are analogous to autocrine, paracine, endocrine , and synaptic signaling. (physicsforums.com)
  • Cell communication: types of cellular communication: endocrine, paracrine, autocrine and iuxtacrine. (univr.it)
  • The events of early pregnancy are tightly coordinated by means of endocrine, paracrine, juxtacrine, and autocrine cellular communication pathways. (glowm.com)
  • In particular, the surfaces of exosomes form fascinating interfaces that may mediate their transport between cells, e.g. both as autocrine and paracrine factors in tumour microenvironments, as well as effectors for distant cellular targets, analogous to endocrine signalling. (royalsocietypublishing.org)
  • This Review focuses on the roles of autocrine purinergic signalling in the regulation of both innate and adaptive immune responses and discusses the potential of targeting purinergic receptors for treating immune-mediated disease. (nih.gov)
  • De-regulation of the autocrine Wnt signaling pathway via mutations in APC and Axin have been linked to activation of various types of human cancer. (wikipedia.org)
  • Genetic alterations that lead to de-regulation of the autocrine Wnt pathway result in transactivation of epidermal growth factor receptor (EGFR) and other pathways, in turn contributing to proliferation of tumor cells. (wikipedia.org)
  • Autocrine regulation of toxin synthesis by Staphylococcus aureus . (igem.org)
  • It is likely that muscle contraction represents the primary stimulus for the synthesis and secretion of myokines to enable communication with other organs such as the liver, adipose tissue, brain, and auto-regulation of muscle metabolism. (frontiersin.org)
  • These results suggest that CRSBP-1 plays a role in autocrine regulation of cell growth mediated by growth regulators containing CRS. (elsevier.com)
  • A simple but efficient way to provide such regulation is through an autocrine feedback mechanism in which the secreted hormone is "sensed" by its respective receptor and initiates synthesis at the level of transcription and/or translation. (elsevier.com)
  • We show that glucagon, secreted by the pancreatic α cell, up-regulates the expression of its own gene by signaling through the glucagon receptor, PKC, and PKA, supporting the more general applicability of an autocrine feedback mechanism in regulation of peptide hormone synthesis. (elsevier.com)
  • Ohhara Y, Shimada-Niwa Y, Niwa R , Kayashima Y, Hayashi Y, Akagi K, Ueda H, Yamakawa-Kobayashi K, Kobayashi S. Autocrine regulation of ecdysone synthesis by 3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis. (go.jp)
  • These results provide a novel molecular mechanism for autocrine negative feedback regulation of insulin secretion. (elsevier.com)
  • Therefore, PDGF is implicated in the autocrine regulation of DDT1MF-2 cell proliferation. (scripps.edu)
  • The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. (nature.com)
  • Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. (nature.com)
  • The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. (nature.com)
  • Although AMFR (autocrine motility factor receptor) is well known as a conventional receptor of AMF, which is a protein secreted by tumor cell stimulating tumor motility. (biomedcentral.com)
  • Auf www.antikoerper-online.de finden Sie aktuell 65 Autocrine Motility Factor Receptor (AMFR) Antikörper von 18 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Huang, Xie, Raz: Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor. (antikoerper-online.de)
  • Further investigation revealed that mutant EGFR could activate the oncogenic STAT3 pathway via upregulated IL-6 autocrine signaling. (wikipedia.org)
  • There is also evidence that glucose, through the hexosamine pathway, can induces autocrine activation of Wnt signalling pathway by stimulating secretion of Wnt proteins. (isciii.es)
  • We conclude that IL-3 deprivation activates 24p3 transcription, leading to synthesis and secretion of 24p3, which induces apoptosis through an autocrine pathway. (umassmed.edu)
  • A key pathway that allows such communication is gap junction (GJ). (physiology.org)
  • In this tumor, the ET-1/ET A R autocrine pathway promotes mitogenesis, apoptosis protection, invasion, and neoangiogenesis. (aacrjournals.org)
  • Recent research revealed that IL-6 secretion induced by HER2 overexpression activated STAT3 and altered gene expression, resulting in an autocrine loop of IL-6/STAT3 expression. (wikipedia.org)
  • Respiration ANS: D NURSINGTB.COM The cell's ability to absorb oxygen is referred to as respiration while its communication ability involves maintenance of a steady dynamic state, metabolic absorption provides nutrition, and secretion allows for the synthesizing of new substances. (coursehero.com)
  • This mode of communication is governed both by physicochemical transport processes and cellular secretion rates, which in turn are determined by genetic and biochemical processes. (pnas.org)
  • These results suggested that the tumor cells stimulated their growth through an activin A autocrine signaling pathwa, a hypothesis confirmed by activin A secretion in cultured GCT cells which proliferated in response. (aacrjournals.org)
  • 2017). Classical concepts of metabolism as, for example how glucose stimulates insulin secretion are currently being rewritten to include important components of signalling metabolites being sensed by selective metabolite GPCRs often in an autocrine manner (Trauelsen et al Cell Metabol. (medicinoxy.com)
  • Released insulin from β-cells inhibits insulin and glucagon secretion with autocrine and paracrine modes. (elsevier.com)
  • Stimulation of almost all mammalian cell types leads to the release of cellular ATP and autocrine feedback through a diverse array of purinergic receptors. (nih.gov)
  • Depending on the types of purinergic receptors that are involved, autocrine signalling can promote or inhibit cell activation and fine-tune functional responses. (nih.gov)
  • Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell. (wikipedia.org)
  • The group looked at the expression of 1,894 ligand-receptor pairs-based on 642 ligands and 589 receptors-that have been reported in the literature so far, and drew up a large-scale map of cell-to-cell communication between 144 primary human cell types. (healthcanal.com)
  • Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss. (burrillandco.com)
  • ETs and their receptors have been implicated in tumor progression through autocrine and paracrine pathways. (aacrjournals.org)
  • On the other hand, IL-15 effect on human eosinophil is through inhibition of the spontaneous apoptosis via the autocrine production of GM-CSF and thus may perpetuate allergic inflammation by prolonged eosinophil survival [ 4 ]. (hindawi.com)
  • We test these analytical results by stochastic simulations with efficient Brownian dynamics code and apply our model to analyze the spatial operation of autocrine epidermal growth factor receptor systems. (princeton.edu)
  • Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). (wikipedia.org)
  • In Wnt signaling, these proteins act as ligands to activate the different Wnt pathways via paracrine and autocrine routes. (wikipedia.org)
  • SVZ progenitor cells express transcripts for the appropriate BMP-specific type I and II receptor subunits and selective BMP ligands, suggesting the presence of paracrine or autocrine developmental signaling pathways (or both). (elsevier.com)
  • These results show that IL-8 induces autocrine signalling via an apical CXCR1 in Caco-2 BBE intestinal epithelial cells and that this receptor is also expressed on the apical surface of differentiated human intestinal epithelial cells in vivo, suggesting an autocrine function for IL-8 secreted in the lumen. (wur.nl)
  • Ang-2 is mainly produced by endothelial cells and therefore acts primarily in an autocrine manner. (biologists.org)
  • VEGF, produced by carcinoma cells, acts through paracrine signaling on endothelial cells and through autocrine signaling on carcinoma cells. (wikipedia.org)
  • These interactions include not only cell-to-cell communication among malignant cells, but also interactions between malignant and stromal cells within the extracellular matrix, including vascular endothelial cells and cancer-associated fibroblasts. (frontiersin.org)
  • CFs interact with not only cardiac myocytes (CMs) but also with other cells in the heart, including vascular endothelial cells (ECs), smooth muscle cells (SMCs), and immune cells, via direct or indirect cellular communications. (rochester.edu)
  • Intriguingly, miRNAs can be transferred from cell to cell by exosomes, small vesicles that have been shown to mediate the transfer of proteins and RNAs, thus facilitating the exchange of information among cells this might have important implications in autocrine and paracrine communication between both macrophages and endothelial cells. (yale.edu)
  • The absolute co-expression of ERL1 and MUTE, with the co-presence of EPF1, triggers autocrine inhibition of stomatal fate. (elifesciences.org)
  • During normal stomatal development, this autocrine inhibition prevents extra symmetric divisions of stomatal precursors likely owing to excessive MUTE activity. (elifesciences.org)
  • Inhibition of autocrine activin signaling by either SB431542 or follistatin reduced both Smad2 activation and Oct4A/Nanog upregulation. (nih.gov)
  • Inhibition of autocrine TGF-β signaling by either SB431542 or anti-TGF-β antibody reduced Smad3 activation and strongly increased the number of Ki67-positive cells. (nih.gov)
  • Recent work has shown that autocrine signalling is an important checkpoint in immune cell activation and allows immune cells to adjust their functional responses based on the extracellular cues provided by their environment. (nih.gov)
  • Our results show a widespread dependence of AML cells on autocrine activation of MET, as well as the key role of compensatory upregulation of HGF expression in maintaining leukemogenic signaling by this receptor. (nih.gov)
  • Real-Time Cell Analysis (RTCA) assays were performed to assess whether AMF depends on Autocrine motility factor recepter (AMFR) signaling in EC cells. (biomedcentral.com)
  • The authors showed that the metastatic potential of oncogenic mammary epithelial cells required an autocrine PDGF/PDGFR signaling loop, and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. (wikipedia.org)
  • Which form of cell communication is used to relate to other cells in direct physical contact? (coursehero.com)
  • Gap junctions allow for cellular communication between cells. (coursehero.com)
  • More notably, the transfer of these varied molecules almost invariably plays a critical role in the communication between cancer cells themselves in an effort to resist death by chemotherapy and promote the growth and metastases of the primary oncogenic cell. (frontiersin.org)
  • Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-ß signaling. (abcam.com)
  • Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β. (nih.gov)
  • siRNA-based suppression of VEGF expression in a Müller cell line in vitro supports the existence of an autocrine role for VEGF in Müller cell survival.These results indicate an important role for endogenous VEGF in the maintenance and function of adult retina neuronal cells and indicate that anti-VEGF therapies should be administered with caution. (nih.gov)
  • Paracrine communication involves chemical messengers between cells within one tissue. (scribd.com)
  • Autocrine cells act on the same cell that produced them. (scribd.com)
  • The process requires innate response activator (IRA) B cells, a transitional B1a-derived inflammatory subset which controls IgM production via autocrine granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. (rupress.org)
  • Cells communicate in ways that are analogous to human communication. (physicsforums.com)
  • Paracrine communication involves local diffusion of regulators from producer cells to distinct target cells within the same organ. (glowm.com)
  • This process is particularly critical during early embryonic development when a cell's differentiation and ultimate fate are controlled by communication with neighboring cells. (healthcanal.com)
  • In their struggle to survive and prosper, multicellular organisms rely on a complex network of communication between cells, which in humans are believed to number about 40 trillion. (riken.jp)
  • It has been shown to be responsible for cell surface retention of the v-sis gene product in v-sis-transformed cells (fibroblasts) and has been hypothesized to play a role in autocrine growth and transformation of these cells. (elsevier.com)
  • CRSBP-1 overexpression (by stable transfection of cells with CRSBP-1 cDNA) enhances autocrine loop signaling, cell growth, and tumorigenicity (in mice) of v-sis-transformed cells. (elsevier.com)
  • CRSBP-1 expression also enhances autocrine cell growth mediated by IGFBP-3 in human lung carcinoma cells (H1299 cells), which express very little, if any, endogenous CRSBP-1 and exhibits a mitogenic response to exogenous IGFBP-3, stably transfected with IGFBP-3 cDNA. (elsevier.com)
  • Throughout growth, Dictyostelium cells continuously produce an autocrine factor, PSF, that accumulates in proportion to cell density. (nih.gov)
  • Neurons are the cells within the brain that are responsible for rapid communication of information. (thefreelibrary.com)
  • Currently, the spatial distribution of diffusing signals can be analyzed only indirectly, from their effects on the intracellular signaling or physiological responses of autocrine cells. (princeton.edu)
  • The regulatory response conditions involving IL10 can act in an autocrine manner to suppress the activity of NK cells, macrophages and Th1 cells, all of which are obligatory for pathogen clearance can add to tissue injury. (sciencemag.org)
  • Q. Communication between cells can occur by all of the following basic mechanisms excepta. (clutchprep.com)
  • Here, we report that uncontrolled PI3K activity within oocytes irreversibly transforms granulosa cells (GC), causing GC tumors (GCT) through perturbed local cell-communication. (aacrjournals.org)
  • Although communication between the oocyte and surrounding somatic cells is critical for the normal development of ovarian follicles, perturbations in oocyte-GC communication during early folliculogenesis can induce GCT by activating an autocrine growth circuit program in GC. (aacrjournals.org)
  • The later is mainly due to abnormal classical changes in the blood- released hormone to its targeted organ, abnormal communication between cells within a tissue or organ (paracri. (intechopen.com)
  • The later is mainly due to abnormal classical changes in the blood- released hormone to its targeted organ, abnormal communication between cells within a tissue or organ (paracrine), within the same cell (intracrine) or signals which act on the same cell (autocrine). (intechopen.com)
  • Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors. (wikipedia.org)
  • The present project is based on the notion that lactate and ketone bodies function as local extracellular signals of fuel availability and metabolic stress, which in autocrine and paracrine manners are sensed by HCARs to reprogram adipocyte function. (medicinoxy.com)
  • Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. (nature.com)
  • Taken together, the data demonstrate for the first time the antagonistic Ang-1/Ang-2 concept in a defined cellular model and identify Ang-2 as a rapidly acting autocrine regulator of the endothelium that acts through an internal autocrine loop mechanism. (biologists.org)
  • Here, we demonstrate that membrane vesicles released by mesoangioblasts contain Hsp70, and that the released Hsp70 is able to interact by an autocrine mechanism with Toll-like receptor 4 (TLR4) and CD91 to stimulate migration. (unipa.it)
  • Expression of early developmental genes in Dictyostelium discoideum is initiated during exponential growth by an autocrine-dependent mechanism. (nih.gov)
  • Another agent involved in autocrine cancer signaling is vascular endothelial growth factor (VEGF). (wikipedia.org)
  • Neither desmosomes nor tight junctions are associated with cellular communication. (coursehero.com)
  • Cellular communication is a critical component of heterotypic and homotypic interactions in the complex, ever-changing tumor microenvironment. (frontiersin.org)
  • Gap junction proteins are integral membrane proteins present in both vertebrates and invertebrates that participate in cellular communication. (intechopen.com)
  • Herein, we showed that autocrine motility factor (AMF) binds G protein-coupled estrogen receptor 1 (GPER-1) and then translocates from the plasma membrane to the cytoplasm. (biomedcentral.com)
  • Biochemical and Biophysical Research Communications , 468 (4), 752-757. (elsevier.com)
  • Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. (wikipedia.org)
  • Their research showed that autocrine IL-6 signaling induced malignant features in Notch-3 expressing mammospheres. (wikipedia.org)
  • One study showed that autocrine PDGFR signaling plays an essential role in epithelial-mesenchymal transition (EMT) maintenance in vitro, which is known to correlate well with metastasis in vivo. (wikipedia.org)
  • Estimates for the time scale on which signaling takes place and the effective communication distances are needed. (pnas.org)
  • PCMO responded to both growth factors in an autocrine fashion with intracellular signaling as evidenced by a rise in the levels of phospho-Smad2 and a drop in those of phospho-Smad3. (nih.gov)
  • D) talking to yourself: This would be autocrine signaling. (physicsforums.com)
  • In autocrine signaling the signaling and target cell are physically the same. (physicsforums.com)
  • Defects in cell-cell communication, including the dysregulation of autocrine signaling, are also implied in the development of cancer, and autoimmune and metabolic diseases. (healthcanal.com)
  • Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. (thefullwiki.org)
  • Here we review applications of several of these approaches, including principal component analysis, partial least squares regression, partial least squares discriminant analysis, decision trees, and Bayesian networks, and describe the advances they have offered in systems-level understanding of immune cell signaling and communication. (springer.com)
  • Autocrine signaling systems are commonly studied under cell culture conditions. (princeton.edu)
  • This makes IGF-1 a good protagonist at targeting tissues to spur cell to cell communication (growth) or in a more autocrine cell signaling process that facilitates cell division. (burrillandco.com)
  • Extracellular AMP is hydrolyzed to adenosine by ecto-5'-nucleotidase (eN) as well as by APs. (wikipedia.org)
  • Evidence shows that autocrine VEGF is involved in two major aspects of invasive carcinoma: survival and migration. (wikipedia.org)
  • siRNA-based suppression of VEGF expression in a Müller cell line in vitro supports the existence of an autocrine role for VEGF in Müller cell survival. (nih.gov)
  • Cell-to-cell communication is a process necessary for physiological tissue homeostasis and appears often altered during disease. (physiology.org)
  • Intracellular dialysis of Ang I (10 −8 mol/L) abolished cell communication in myopathic cell pairs with low gj (0.8 to 2.5 nS) and reduced gj by 66±1.7% in the other pairs (7 to 35 nS). (ahajournals.org)
  • In particular, our previous study unveiled the role of GPR30 (now call GPER1), the membrane G protein-coupled estrogen receptor, in mediating the estrogen action during ovarian cell-cell communication and follicle development. (massgeneral.org)
  • Abstract The influence of heart failure on the process of cell communication was investigated in cell pairs isolated from the ventricle of cardiomyopathic hamsters (11 months old) and the results compared with age-matched normal hamsters. (ahajournals.org)
  • Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma," Journal of Biological Chemistry , vol. 280, no. 25, pp. 23987-24003, 2005. (hindawi.com)
  • However, the underlying molecular mechanisms, cell-cell communication, and autocrine/paracrine factors involved in cellular interplay are largely unknown. (rochester.edu)
  • This article will focus on the basic processes underlying neuronal communication and review the neuronal actions of several neurotransmitters, neurotrophic factors, and hormones thought to be involved in the neural actions of alcohol. (thefreelibrary.com)
  • Data obtained over the last 5 years in several laboratories have revitalized a controversial concept, namely the autocrine feedback action of secreted insulin on beta-cell function. (nih.gov)
  • Here, we investigated the effect of autocrine insulin on surface abundance of K ATP channel in mouse clonal β-cell line, MIN6. (elsevier.com)
  • Narrowly regulated cell-cell communication plays critical role in the follicle cell proliferation, differentiation, steroidogenesis, oocyte maturation and ovulation. (massgeneral.org)
  • 23 Previous studies 24 indicated that the RAS plays an important role in the modulation of cell-to-cell communication in normal rat heart. (ahajournals.org)
  • One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. (wikipedia.org)
  • An example of an autocrine agent is the cytokine interleukin-1 in monocytes. (wikipedia.org)
  • In a growing number of experiments, it is important to characterize the spatial range of autocrine and paracrine cell communication. (princeton.edu)
  • Besides glucose, the major nutrient factor, inputs from neural and humoral components and intraislet cell-cell communication act together to guarantee an appropriate pancreatic beta-cell function. (nih.gov)
  • Some cell-to-cell communication requires direct cell-cell contact . (thefullwiki.org)
  • Looking forward, new experimental technologies involving single-cell measurements of cytokine expression beckon extension of these modeling techniques to inference of immune cell-cell communication networks, with a goal of aiding development of improved vaccine therapeutics. (springer.com)