Autocrine Communication
Communication
Cell Communication
Animal Communication
Communication Disorders
Health Communication
Communication Aids for Disabled
Equipment that provides mentally or physically disabled persons with a means of communication. The aids include display boards, typewriters, cathode ray tubes, computers, and speech synthesizers. The output of such aids includes written words, artificial speech, language signs, Morse code, and pictures.
Nonverbal Communication
Paracrine Communication
Communication Barriers
Computer Communication Networks
Connexin 43
Radiology Information Systems
Receptors, Autocrine Motility Factor
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Interdisciplinary Communication
Communication, in the sense of cross-fertilization of ideas, involving two or more academic disciplines (such as the disciplines that comprise the cross-disciplinary field of bioethics, including the health and biological sciences, the humanities, and the social sciences and law). Also includes problems in communication stemming from differences in patterns of language usage in different academic or medical disciplines.
Cell Division
Cells, Cultured
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Communication Methods, Total
Connexins
Communications Media
Glucose-6-Phosphate Isomerase
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Tumor Cells, Cultured
Transforming Growth Factor alpha
Growth Substances
Electronic Mail
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Persuasive Communication
Patient Satisfaction
Culture Media, Conditioned
Attitude of Health Personnel
Internet
Transforming Growth Factor beta
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Patient Simulation
Role Playing
Reverse Transcriptase Polymerase Chain Reaction
Teleradiology
The electronic transmission of radiological images from one location to another for the purposes of interpretation and/or consultation. Users in different locations may simultaneously view images with greater access to secondary consultations and improved continuing education. (From American College of Radiology, ACR Standard for Teleradiology, 1994, p3)
Questionnaires
Models, Biological
Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. (1/1262)
The EPH family is the largest subfamily of receptor protein tyrosine kinases, consisting of the EPHA and EPHB subgroups. Ephrin-B1, ephrin-B2, and ephrin-B3 are ligands of the EPHB subgroup and are encoded by the EFNB1, EFNB2, and EFNB3 genes, respectively. We have shown previously that EPHB2 transcripts are expressed in six small cell lung carcinoma (SCLC) cell lines. In this study, we examined the expression of EPHB1, EPHB2, EPHB3, EPHB4, and EPHB6 in 4 SCLC tumor specimens and 14 cell lines including 3 cell lines derived from these tumor specimens. To investigate whether potential autocrine loops of EPHB receptors and ephrin-B ligands exist in SCLC, the expression of EFNB1, EFNB2, and EFNB3 was also examined. Our data show that transcripts encoding multiple members of the EPHB subgroup and the ephrin-B subgroup are coexpressed in SCLC cell lines and tumors. These results suggest that the EPHB subgroup receptor kinases may modulate the biological behavior of SCLC through autocrine and/or juxtacrine activation by ephrin-B ligands that are expressed in the same or neighboring cells. (+info)Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. (2/1262)
The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by influenza virus infection and by double-stranded (ds)RNA. This activation results not only in increased antigen presentation and T cell stimulatory capacity, but also in resistance to the cytopathic effect of the virus, mediated by the production of type I interferon, and upregulation of MxA. Because dsRNA stimulates both maturation and resistance, DCs can serve as altruistic antigen-presenting cells capable of sustaining viral antigen production while acquiring the capacity to trigger naive T cells and drive polarized T helper cell type 1 responses. (+info)Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1alpha. (3/1262)
PURPOSE: The matrix metalloproteinase gelatinase B is synthesized by cells at the leading edge of the corneal epithelium migrating to heal a wound. Recent data from the authors' laboratory suggest that excessive synthesis contributes to repair defects. The goal of the study reported here was to investigate mechanisms controlling gelatinase B production by corneal epithelial cells. METHODS: Freshly isolated cultures of corneal epithelial cells and early passage stromal fibroblasts from rabbit were used for these studies. RESULTS: In a previous study, it was found that the cytokine interleukin (IL)-1alpha is released into the culture medium of corneal epithelial cells more efficiently when they are plated at low density with limited cell-cell contact than when plated at high density. In this study, we show that production of gelatinase B by these cells is similarly affected by cell plating density. However, it is further demonstrated that these two events are not dependent on one another but occur in parallel: IL-1alpha does not regulate gelatinase B production (synthesis), nor was there evidence that any other secreted autocrine cytokine acts as mediator. Instead, our data suggest that gelatinase B production is downregulated directly by high cell density and indicate a connection to the level of protein kinase C activity. Nevertheless, the anticancer agent suramin, which blocks collagenase synthesis by interfering with autocrine cytokine-receptor interactions, still inhibits synthesis of gelatinase B. CONCLUSIONS: Unlike collagenase synthesis by corneal stromal fibroblasts, production (synthesis) of gelatinase B does not appear to be controlled by secreted autocrine cytokines but can still be inhibited by suramin. Suramin may make an effective therapeutic agent for controlling pathologic overproduction of gelatinase B in corneal ulcers. (+info)Pituitary adenylate cyclase-activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells. (4/1262)
There is increasing evidence that hormones play an important role in the control of endothelial cell function and growth by regulating the production of vascular endothelial growth factor (VEGF). VEGF regulates vascular permeability and represents the most powerful growth factor for endothelial cells. In the normal anterior pituitary, VEGF has been detected only in folliculostellate (FS) cells. In the present study, the regulation of the release of VEGF from FS-like mouse TtT/GF cells, and from FS cells of rat pituitary monolayer cell cultures was investigated using a specific VEGF ELISA. Basal release of VEGF was demonstrated in cultures of both TtT/GF cells and rat pituitary cells. Interestingly, the VEGF secretion was stimulated by both forms of pituitary adenylate cyclase-activating polypeptide (PACAP-38 and PACAP-27), indicating that this hypothalamic peptide regulates endothelial cell function and growth within the pituitary. VEGF secretion was also stimulated by interleukin-6 (IL-6) whereas basal, IL-6- and PACAP-stimulated secretion was inhibited by the synthetic glucocorticoid dexamethasone. The inhibitory action of dexamethasone was reversed by the glucocorticoid receptor antagonist RU486, suggesting that in FS cells functional glucocorticoid receptors mediate the inhibitory action of glucocorticoids on the VEGF secretion. The endocrine and auto-/paracrine control of VEGF production in pituitary FS cells by PACAP, IL-6 and glucocorticoids may play an important role both in angiogenesis and vascular permeability regulation within the pituitary under physiological and pathophysiological conditions. (+info)Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets. (5/1262)
We compared several responses in thrombin-stimulated and collagen (type I)-stimulated platelets with and without forskolin and inhibitors of autocrine stimulation (IAS: an ADP-removing system of creatine phosphate/creatine phosphokinase, Arg-Gly-Asp-Ser peptide to prevent fibrinogen/fibronectin binding to GPIIb/IIIa, SQ 29.548 as a thromboxane A2 receptor antagonist, cyproheptadine as a serotonin receptor antagonist, BN 52021 as a platelet-activating factor receptor antagonist). The pattern of tyrosine-phosphorylated proteins, the phosphorylation of lipids in the polyphosphoinositide cycle and phosphorylation of pleckstrin (P47) were studied as markers for signal-transducing responses, exposure of CD62 (P-selectin) and CD63 (Glycoprotein 53), as well as secretion of ADP + ATP and beta-N-acetyl-glycosaminidase were studied as final activation responses. Clear differences between thrombin-stimulated and collagen-stimulated platelets were observed. First, practically all protein-tyrosine phosphorylation induced by thrombin was inhibited by IAS, while a partial inhibition was observed for collagen; the phosphorylation due to collagen alone was apparently stimulated by elevation of cAMP. Secondly, the other responses to thrombin were inhibited by increased levels of cAMP, independent of autocrine stimulation. In contrast, only the autocrine part of the collagen-induced responses was inhibited by elevation of cAMP. Thus, the inhibition by elevated cAMP seen in collagen-stimulated platelets seems to be due to removal of the G-protein-mediated activation from secreted autocrine stimulators either by IAS or forskolin. The remaining activity is a pure collagen effect which is not affected by elevated levels of cAMP. (+info)Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid. (6/1262)
PURPOSE: Expression of the genes for collagenase and interleukin-1alpha (IL-1alpha) are induced as stromal cells become activated to the repair fibroblast phenotype after injury to the cornea. This investigation examines the mechanisms whereby expression of these genes is inhibited by transforming growth factor-beta (TGF-beta), dexamethasone (DEX), or retinoic acid (RET A). METHODS: A model of freshly isolated cultures of corneal stromal cells and early passage cultures of corneal fibroblasts was used in these studies. This model reproduces the events of stromal cell activation in the corneal wound. RESULTS: In early passage cultures of corneal fibroblasts, expression of collagenase is under obligatory control by autocrine IL-1alpha. IL-1alpha controls its own expression through an autocrine feedback loop that is dependent on transcription factor NF-kappaB. TGF-beta, DEX, and RET A were each effective inhibitors of collagenase gene expression in these cells. Furthermore, these agents have the capacity to inhibit expression of IL-1alpha and this was correlated with their ability to affect DNA-binding activity of NF-kappaB. However, TGF-beta, DEX, and RET A were also effective inhibitors of the low level of collagenase expressed by freshly isolated corneal stromal cells that cannot express IL-1alpha. CONCLUSIONS: In cells with an active IL-1alpha autocrine loop there are at least two distinct signaling pathways by which collagenase gene expression can be modulated. The results of this study demonstrate that TGF-beta, DEX, and RET A differentially inhibit collagenase and IL-1alpha gene expression. This information will be useful in the design of therapeutic modalities for fibrotic disease in the cornea and other parts of the eye. (+info)The role of macrophage cell death in tuberculosis. (7/1262)
Studies of host responses to infection have traditionally focused on the direct antimicrobial activity of effector molecules (antibodies, complement, defensins, reactive oxygen and nitrogen intermediates) and immunocytes (macrophages, lymphocytes, and neutrophils among others). The discovery of the systems for programmed cell death of eukaryotic cells has revealed a unique role for this process in the complex interplay between microorganisms and their cellular targets or responding immunocytes. In particular, cells of the monocyte/macrophage lineage have been demonstrated to undergo apoptosis following intracellular infection with certain pathogens that are otherwise capable of surviving within the hostile environment of the phagosome or which can escape the phagosome. Mycobacterium tuberculosis is a prototypical 'intracellular parasite' of macrophages, and the direct induction of macrophage apoptosis by this organism has recently been reported from several laboratories. This paper reviews the current understanding of the mechanism and regulation of macrophage apoptosis in response to M. tuberculosis and examines the role this process plays in protective immunity and microbial virulence. (+info)Ligation of Fc gamma RII (CD32) pivotally regulates survival of human eosinophils. (8/1262)
The low-affinity IgG Fc receptor, FcgammaRII (CD32), mediates various effector functions of lymphoid and myeloid cells and is the major IgG Fc receptor expressed by human eosinophils. We investigated whether FcgammaRII regulates both cell survival and death of human eosinophils. When cultured in vitro without growth factors, most eosinophils undergo apoptosis within 96 h. Ligation of FcgammaRII by anti-CD32 mAb in solution inhibited eosinophil apoptosis and prolonged survival in the absence of growth factors. Cross-linking of human IgG bound to FcgammaRII by anti-human IgG Ab or of unoccupied FcgammaRII by aggregated human IgG also prolonged eosinophil survival. The enhanced survival with anti-CD32 mAb was inhibited by anti-granulocyte-macrophage-CSF (GM-CSF) mAb, suggesting that autocrine production of GM-CSF by eosinophils mediated survival. In fact, mRNA for GM-CSF was detected in eosinophils cultured with anti-CD32 mAb. In contrast to mAb or ligands in solution, anti-CD32 mAb or human IgG, when immobilized onto tissue culture plates, facilitated eosinophil cell death even in the presence of IL-5. Cell death induced by these immobilized ligands was accompanied by DNA fragmentation and was inhibited when eosinophil beta2 integrin was blocked by anti-CD18 mAb, suggesting that beta2 integrins play a key role in initiating eosinophil apoptosis. Thus, FcgammaRII may pivotally regulate both survival and death of eosinophils, depending on the manner of receptor ligation and beta2 integrin involvement. Moreover, the FcgammaRII could provide a novel mechanism to control the number of eosinophils at inflammation sites in human diseases. (+info)
TNF-α Autocrine Feedback Loops in Human Monocytes: The Pro- and Anti-Inflammatory Roles of the TNF-α Receptors Support the...
Sulf-2 knockdown effect on autocrine Wnt signaling (a) | Open-i
Nitric oxide but not prostacyclin has an autocrine function in porcine aortic endothelial cells. - Fingerprint
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IGFBP3 and IGFBP2 negatively and positively modulate IGFs autocrine effect in lung cancer cell lines | ECE2009
IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential...
Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical...
Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid...
Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in...
The contribution of vitamin A to autocrine regulation of fat depots
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Immune cell regulation by autocrine purinergic signalling
People - Cell Biology and Physiology - UNC School of Medicine
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Autocrine signaling in 3 dimensions | PRiME portal
Autocrine Signaling | Protocol (Translated to Chinese)
Autocrine Signaling | Protocol (Translated to Chinese)
Activation via the CD3 and CD16 pathway mediates interleukin-2-dependent autocrine proliferation of granular lymphocytes in...
Mechanism of hippocampal neuron death in the trisomy 16 mouse: Failure of BDNF signaling
Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function. - PubMed -...
E-GEOD-40849 - Vav proteins orchestrate a keratinocyte auto/paracrine program critical for skin tumorigenesis. - OmicsDI
Autocrine regulation of asthmatic airway inflammation: role of airway smooth muscle | Respiratory Research | Full Text
Autocrine Regulation of Myocyte Cx43 Expression by VEGF | Circulation Research
Gianfranco Alpini, PhD
Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology - Immunology
Phosphoinositide 3-kinase γ: a key modulator in inflammation and allergy | Biochemical Society Transactions
Autocrine-paracrine inhibition of growth hormone and prolactin production by GH|sub|3|/sub| cell-conditioned medium -...
Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human...
Terry Evans | Melatonin membrane receptors in peripheral tissues
Autocrine signalling - Wikipedia
Purified anti-human/mouse IL-21 Antibody anti-IL-21 - 7H20-I19-M3
Purified anti-human/mouse IL-21 Antibody anti-IL-21 - 7H20-I19-M3
Search Articles | University of Toronto Libraries
The Antiviral Response to Gamma Interferon | Journal of Virology
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Olympus® GIF-XP230 Gastroscope - IEC - Innovative Endoscopy Company, Inc.
FGF Induces Hypertrophy and Angiogenesis in Hibernating Myocardium | Circulation Research
Lipoxygenase - Wikipedia
Endotoxins modulate the autocrine function of organ cultured donor corneas and increase the incidence of endothelial cell death...
Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell...
Autocrine Activation of Neuronal NMDA Receptors by Aspartate Mediates Dopamine- and cAMP-Induced CREB-Dependent Gene...
Autocrine | definition of autocrine by Medical dictionary
Association between Interleukin-18 Polymorphisms and Hepatocellular Carcinoma Occurrence and Clinical Progression
Centrum Wiskunde & Informatica:
Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in the...
Autocrine signaling - Wikipedia
Nitric oxide-generating system as an autocrine mechanism in hu...
Programmed cell death has a vital role in embryonic development and - BRAF inhibitors on Immune-based antitumor therapy
CMS-MITACS Joint Conference 2007
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Cytokines
autocrine hypothesis
VEGF-A promoted DJM-1 cell proliferation via NRP1 in an | Open-i
Cell biology
Communication can occur through direct cell contact or endocrine, paracrine, and autocrine signaling. Direct cell-cell contact ... Autocrine is a cell sending a signal to itself by secreting a molecule that binds to a receptor on its surface. Forms of ... Cell communication is important for cell regulation and for cells to process information from the environment and respond ... cell communication, cell cycle, biochemistry, and cell composition. The study of cells is performed using several techniques ...
Stuart C. Sealfon
PMID 19356622.CS1 maint: multiple names: authors list (link) Sugar I.P., Sealfon S.C. (2009). "Model of autocrine/paracrine ... signaling in epithelial layer: geometrical regulation of intercellular communication". J Phys Chem B. 113 (31): 10946-56. doi: ...
Wnt signaling pathway
... s use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are ... In Wnt signaling, these proteins act as ligands to activate the different Wnt pathways via paracrine and autocrine routes. ... Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.Int. J. Cancer ... January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5 ...
Granulin
Zhou J, Gao G, Crabb JW, Serrero G (May 1993). "Purification of an autocrine growth factor homologous with mouse epithelin ... Nature Communications. 8: 15277. Bibcode:2017NatCo...815277Z. doi:10.1038/ncomms15277. PMC 5477518. PMID 28541286. Nguyen AD, ... Progranulin may function as an autocrine growth factor in tumorigenesis. The discovery of a GRN mutation leading to lysosomal ... Serrero G (August 2003). "Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in ...
Purinergic signalling
Autocrine purinergic signalling is an important checkpoint in the activation of white blood cells. These mechanisms either ... It has an excitatory effect on neurones, and acts as a mediator in neuronal-glial communications. Both adenosine and ATP induce ... The release of ATP and an autocrine feedback through P2RY2 and A3 receptors are signal amplifiers. Hypoxia-inducible factors ... Corriden, R.; Insel, P. A. (5 January 2010). "Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation". ...
Paracrine signaling
... is form of cell signaling, a type of cellular communication in which a cell produces a signal to induce ... and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. ...
Macrophage polarization
Sica A, Saccani A, Bottazzi B, Polentarutti N, Vecchi A, van Damme J, Mantovani A (January 2000). "Autocrine production of IL- ... Nature Communications. 8: 14293. Bibcode:2017NatCo...814293C. doi:10.1038/ncomms14293. PMC 5309815. PMID 28176769. Zeisberger ...
Connexin
Recent studies have shown the existence of communication between adherens junctions and gap junctions, suggesting a higher ... connexin hemichannels and pannexin channels can contribute to autocrine/paracrine signaling pathways, and (3) different ... "Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by ... "Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with ...
Endocrinology
This definition holds for most "classical" hormones, but there are also paracrine mechanisms (chemical communication between ... cells within a tissue or organ), autocrine signals (a chemical that acts on the same cell), and intracrine signals (a chemical ...
Folliculostellate cell
"Cell-to-cell communication in the anterior pituitary: evidence for gap junction-mediated exchanges between endocrine cells and ... autocrine/paracrine control of anterior pituitary cell function though the use of cytokines and growth factors, intrapituitary ... as the IL-6 is a mediator in communication between the endocrine and immune system. IL-6 production by FS cells induces hormone ... A route for long-distance communication in the anterior pituitary". Proceedings of the National Academy of Sciences. 98 (15): ...
Oogenesis
Endocrine, paracrine, and autocrine signaling pathways that regulate ovulation. Trends Endocrinol. Metab. 29:313-325. NCBI - ... Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle. Ann. Rev. Physiol. 79:237- ... Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle. Ann. Rev. Physiol. 79:237- ...
Autocrine signaling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine ... Autocrine+signaling at the US National Library of Medicine Medical Subject Headings (MeSH) "Autocrine versus juxtacrine ... and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR ...
Sardul Singh Guraya
... and Autocrine Regulation of Structure and Functions, Cellular And Molecular Biology For Human, (all on Cell and Molecular ... and Intercellular Communication. Science Publishers. ISBN 978-1-57808-066-3. "Guraya SS[au] on Pubmed". Pubmed. 2016. Retrieved ... and Autocrine Regulation of Structure and Functions. Science Publishers. ISBN 978-1-57808-165-3. Sardul S. Guraya (1 January ... and Autocrine Regulation of Structure and Functions. Science Publishers. ISBN 978-1-57808-165-3. Sardul S. Guraya (1 January ...
Prolactin
The hormone acts in endocrine, autocrine and paracrine manner through the prolactin receptor and numerous cytokine receptors. ... Nature Communications. 5: 5861. Bibcode:2014NatCo...5.5861L. doi:10.1038/ncomms6861. PMC 4284646. PMID 25519203. Porto-Neto LR ... an autocrine growth factor for lymphoproliferation". Proceedings of the National Academy of Sciences of the United States of ... where they regulate hair growth and moulting in an autocrine fashion. Elevated levels of prolactin can inhibit hair growth, and ...
Annexin A2
This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. Epigenetic regulation ... Biochemical and Biophysical Research Communications. 198 (3): 983-9. doi:10.1006/bbrc.1994.1140. PMID 8117306. Maruyama K, ... "Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone ... "Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone ...
Eboluzio, entziklopedia askea.
Takagi, Y.; Fukase, M.; Takata, S.; Yoshimi, H.; Tokunaga, O.; Fujita, T. (1990-04-30) «Autocrine effect of endothelin on DNA ... synthesis in human vascular endothelial cells» Biochemical and Biophysical Research Communications (2): 537-543 ISSN 0006-291X ...
Endocrine system
Autocrine[edit]. Main article: Autocrine signalling. Autocrine signaling is a form of signaling in which a cell secretes a ... Juxtacrine signaling is a type of intercellular communication that is transmitted via oligosaccharide, lipid, or protein ... Endocrine, paracrine, and autocrine signaling have all been implicated in proliferation, one of the required steps of ... The term hormone is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or ...
C-C chemokine receptor type 7
"Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling" ( ... Biochemical and Biophysical Research Communications. 215 (2): 737-43. doi:10.1006/bbrc.1995.2525. PMID 7488016. Schweickart VL ...
LYVE1
... and role in autocrine cell growth of cell surface retention sequence binding protein-1". The Journal of Biological Chemistry. ... Biochemical and Biophysical Research Communications. 288 (4): 1043-6. doi:10.1006/bbrc.2001.5869. PMID 11689016. Mouta Carreira ...
Juxtacrine signalling
2002). "General Principles of Cell Communication". In NCBI bookshelf (ed.). Molecular biology of the cell (4th ed.). New York: ... Other types of cell signaling include paracrine signalling and autocrine signalling. The term "juxtacrine" was originally ... "Autocrine versus juxtacrine signaling modes" - illustration at sysbio.org. ... cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. This signaling can influence the cell ...
Lymphatic endothelium
2003). "Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding ... Biochemical and Biophysical Research Communications. 288 (4): 1043-1046. doi:10.1006/bbrc.2001.5869. PMID 11689016. Mouta ...
Microfluidic cell culture
Recently, co-culture has become the predominant approach to study the effect of cellular communication by culturing two ... autocrine signaling, and juxtacrine signaling. For example, in paracrine signaling, growth factors secreted from one cell ... Bogdanowicz DR, Lu HH (April 2013). "Studying cell-cell communication in co-culture". Biotechnology Journal. 8 (4): 395-6. doi: ... cells can engage in enhanced communication with neighboring cells and cell-extracellular matrix interactions can be modeled. In ...
Neovascularization
These growth factors often act in a paracrine or autocrine fashion; they include fibroblast growth factor, placental growth ... requiring precise coordination of multiple steps and the participation and communication of multiple cell types. The complex ...
Adipogenesis
Choy L, Skillington J, Derynck R (May 2000). "Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte ... Nature Communications. 10 (1): 2757. doi:10.1038/s41467-019-10688-x. PMC 6588633. PMID 31227697.. ...
Implantation (human embryo)
This communication is conveyed by receptor-ligand-interactions, both integrin-matrix and proteoglycan ones. Another ligand- ... It secretes several autocrine factors, targeting itself and stimulating it to further invade the endometrium. Furthermore, ... Human chorionic gonadotropin is an autocrine growth factor for the blastocyst. Insulin-like growth factor 2, on the other hand ... There is massive communication between the blastocyst and the endometrium at this stage. The blastocyst signals to the ...
ABCB5
Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.Int. J. Cancer ... Biochemical and Biophysical Research Communications. 402 (4): 711-7. doi:10.1016/j.bbrc.2010.10.091. PMC 2998991. PMID 20977885 ... January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5 ...
Antineoplastic resistance
2001-12-15). "Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells". Cancer Research. 61 ( ... Biochemical and Biophysical Research Communications. 320 (2): 493-500. doi:10.1016/j.bbrc.2004.06.003. PMID 15219856. Miyashita ...
Succinic acid
As such, succinate links TCA cycle dysfunction or metabolic changes to cell-cell communication and to oxidative stress-related ... Autocrine succinate signaling promotes retinal neovascularization, triggering the activation of angiogenic factors such as ... Cell Communication and Signaling. 14: 3. doi:10.1186/s12964-016-0126-1. PMC 4709936. PMID 26759054. Bardella, Chiara; Pollard, ...
Brain-derived neurotrophic factor
"A BDNF autocrine loop in adult sensory neurons prevents cell death". Nature. 374 (6521): 450-53. Bibcode:1995Natur.374..450A. ... and cognitive stimulation all translates into more neuronal activity and synaptic communication, which can produce structural ...
Autocrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine ... Autocrine signaling at the US National Library of Medicine Medical Subject Headings (MeSH) "Autocrine versus juxtacrine ... and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR ...
CD30
Biochemical and Biophysical Research Communications. 233 (3): 592-600. doi:10.1006/bbrc.1997.6509. PMID 9168896.. ...
Pancreatic islets
Islets can influence each other through paracrine and autocrine communication, and beta cells are coupled electrically to six ...
Apoptosis
"Nature Communications. 6: 7439. Bibcode:2015NatCo...6.7439A. doi:10.1038/ncomms8439. PMC 4490561. PMID 26074490.. ...
Endocrinology
This definition holds for most "classical" hormones, but there are also paracrine mechanisms (chemical communication between ... cells within a tissue or organ), autocrine signals (a chemical that acts on the same cell), and intracrine signals (a chemical ...
Ligand (biochemistry)
"Nature Communications. 1 (7): 100. Bibcode:2010NatCo...1E.100W. doi:10.1038/ncomms1093. PMC 3186516. PMID 20981028.. ...
T helper cell
The autocrine or paracrine secretion of IL-2 can bind to that same Th cell or neighboring Th's via the IL-2R thus driving ... B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication.[3] A ... which acts upon itself in an autocrine fashion. Activated T cells also produce the alpha sub-unit of the IL-2 receptor (CD25 or ...
Cathepsin D
Biochemical and Biophysical Research Communications. 179 (1): 190-6. doi:10.1016/0006-291X(91)91353-E. PMID 1883350.. ... Biochemical and Biophysical Research Communications. 154 (2): 765-72. doi:10.1016/0006-291X(88)90206-9. PMID 3261170.. ...
Vasoactive intestinal peptide
The SCN coordinates daily timekeeping in the body and VIP plays a key role in communication between individual brain cells ... Conconi MT, Spinazzi R, Nussdorfer GG (2006). "Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation ...
脳由来神経栄養因子
"A BDNF autocrine loop in adult sensory neurons prevents cell death". Nature 374 (6521): 450-3. doi:10.1038/374450a0. PMID ... facilitated by direct communication of neurons and vascular cells (94, 134). ... with increasing exercise intensity, brain ...
Guanylate cyclase
... and can also function as an autocrine signal. Depending on cell type, it can drive adaptive/developmental changes requiring ... "Nature Communications. 6 (8046): 8046. doi:10.1038/ncomms9046. PMC 4569695. PMID 26345128.. ...
Autocrine signaling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine ... and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR ... Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors.[ ...
配體 (生物化學) - 维基百科,自由的百科全
Nature Communications. 2010, 1 (7): 100. Bibcode:2010NatCo...1E.100W. PMID 20981028. doi:10.1038/ncomms1093.. 引文格式1维护:显式使用等标签 ( ... 自分泌(英语:Autocrine signaling)/旁分泌. *内
Endocrine system
AutocrineEdit. Main article: Autocrine signalling. Autocrine signaling is a form of signaling in which a cell secretes a ... Juxtacrine signaling is a type of intercellular communication that is transmitted via oligosaccharide, lipid, or protein ... Endocrine, paracrine, and autocrine signaling have all been implicated in proliferation, one of the required steps of ... The term hormone is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or ...
Thioredoxin
They have also recently been found to play a role in cell-to-cell communication.[7] ... "The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell ... suggestive of a role in intercellular communication". Proceedings of the National Academy of Sciences of the United States of ... Biochemical and Biophysical Research Communications. 295 (3): 663-7. doi:10.1016/s0006-291x(02)00727-1. PMID 12099690.. ...
Fibroblast growth factor
Biochemical and Biophysical Research Communications. 261 (3): 756-65. doi:10.1006/bbrc.1999.1039. PMID 10441498.. ... LMW FGF2 is primarily cytoplasmic and functions in an autocrine manner, whereas HMW FGF2s are nuclear and exert activities ... Biochemical and Biophysical Research Communications. 274 (2): 337-43. doi:10.1006/bbrc.2000.3142. PMID 10913340.. ...
Gap junction
Junctional membrane structure of hybrids between communication-competent and communication-incompetent cells". J. Membr. Biol. ... Allows for chemical communication between cells, through the transmission of small second messengers, such as inositol ... Ehrlich, HP; Diez, T (2003). "Role for gap junctional intercellular communications in wound repair". Wound Repair Regen. 11 (6 ... With the apparent ability for one protein alone to enable intercellular communication seen in gap junctions[109] the term gap ...
skin
It is maintained as a stem cell layer through an autocrine signal, TGF-a, and through paracrine signal FGF7 aka keratinocyte ... chemical communication, even anti-bacterial/viral properties for protection against pathogens.[15] ...
Ghrelin
Gastric-brain communication is an essential part of energy homeostasis, and several communication pathways are probable, ... autocrine modulators in health and disease". Clinical and Experimental Pharmacology & Physiology. 37 (1): 125-31. doi:10.1111/j ... Biochemical and Biophysical Research Communications. 374 (1): 60-63. doi:10.1016/j.bbrc.2008.06.114. PMID 18611393.. ... Biochemical and Biophysical Research Communications. 280 (1): 132-38. doi:10.1006/bbrc.2000.4065. PMID 11162489.. ...
Chemical synapse
This can result from changes in presynaptic calcium as well as feedback onto presynaptic receptors, i.e. a form of autocrine ... mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: wiring ...
Gastrointestinal tract
"Nature Communications. 11 (205). doi:10.1038/s41467-019-13882-z. PMC 6954273. PMID 31924764. Retrieved 10 January 2020.. ... are mediated through either intracrine or autocrine mechanisms, indicating that the cells releasing these hormones are ...
Parathyroid hormone-related protein
PTHrP acts as an endocrine, autocrine, paracrine, and intracrine hormone. It regulates endochondral bone development by ... Biochemical and Biophysical Research Communications. 282 (2): 629-34. doi:10.1006/bbrc.2001.4607. PMID 11401507.. ...
12-Hydroxyeicosatetraenoic acid
... these arachidonic acid metabolites act locally as Autocrine signalling and/or Paracrine signaling agents to regulate the ... Biochemical and Biophysical Research Communications. 420 (2): 428-33. doi:10.1016/j.bbrc.2012.03.012. PMID 22426480. Lee, J. W ... Biochemical and Biophysical Research Communications. 261 (1): 218-23. doi:10.1006/bbrc.1999.1012. PMID 10405349. Ding, X. Z.; ... Biochemical and Biophysical Research Communications. 296 (4): 942-8. doi:10.1016/s0006-291x(02)02014-4. PMID 12200139. Vonach, ...
Succinic acid
"Cell Communication and Signaling. 14: 3. doi:10.1186/s12964-016-0126-1. PMC 4709936. PMID 26759054.. ... Autocrine succinate signaling promotes retinal neovascularization, triggering the activation of angiogenic factors such as ... succinate links TCA cycle dysfunction or metabolic changes to cell-cell communication and to oxidative stress-related responses ...
Neuromodulation
Neuropeptides are small proteins used for communication in the nervous system. Neuropeptides represent the most diverse class ...
Neurotransmitter
The presence of such a gap suggested communication via chemical messengers traversing the synaptic cleft, and in 1921 German ... Until the early 20th century, scientists assumed that the majority of synaptic communication in the brain was electrical. ...
Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of...
Biochemical and Biophysical Research Communications 2013 436 3 *. Effects of all-trans-retinoic on human gastric cancer cells ... Autocrine signaling in carcinoma: VEGF and the α6β4 integrin. Arthur M Mercurio, Robin E Bachelder, Richard C Bates, Jun Chung ... Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling ... Potential autocrine function of vascular endothelial growth factor in head and neck cancer via vascular endothelial growth ...
Immune cell regulation by autocrine purinergic signalling
Depending on the types of purinergic receptors that are involved, autocrine signalling can promote or inhibit cell activation ... Stimulation of almost all mammalian cell types leads to the release of cellular ATP and autocrine feedback through a diverse ... Autocrine Communication / physiology* * Chemotaxis / physiology * Humans * Immune Tolerance / physiology * Immunity, Innate / ... Immune cell regulation by autocrine purinergic signalling Nat Rev Immunol. 2011 Mar;11(3):201-12. doi: 10.1038/nri2938. Epub ...
Autocrine Activation of the MET Receptor Tyrosine Kinase in Acute Myeloid Leukemia
Autocrine Communication* / drug effects * Autocrine Communication* / genetics * Cell Line, Tumor * Cell Proliferation / drug ... Autocrine Activation of the MET Receptor Tyrosine Kinase in Acute Myeloid Leukemia Nat Med. 2012 Jul;18(7):1118-22. doi: ... Our results show a widespread dependence of AML cells on autocrine activation of MET, as well as the key role of compensatory ... We found HGF expression leading to autocrine activation of its receptor tyrosine kinase, MET, in nearly half of the AML cell ...
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation | Nature Medicine
Nature Communications (2020) * Amplification of autocrine motility factor and its receptor in multiple myeloma and other ... The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett. 456, 295-300 (1999 ... Nabi, I.R., Watanabe, H. & Raz, A. Identification of B16-F1 melanoma autocrine motility-like factor receptor. Cancer Res. 50, ... Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J. Biol. Chem. 266, 13442- ...
Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1 | Cell Communication and Signaling | Full...
Real-Time Cell Analysis (RTCA) assays were performed to assess whether AMF depends on Autocrine motility factor recepter (AMFR ... Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of ... Cell Communication and Signaling volume 17, Article number: 22 (2019) Cite this article ... Li, Y., Jia, Y., Bian, Y. et al. Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1. Cell ...
The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism | Journal of...
... personal communication). Similarly, an activating Tie-2 mutation causes venous malformations that are composed of dilated ... Moreover, the data identify Ang-2 as a rapid autocrine regulator of vascular stability that acts through an internal autocrine ... However, autocrine Ang-2-mediated endothelial-cell detachment cannot be blocked by soluble Tie-2. Taken together, the data ... Keating, M. T. and Williams, L. T. (1988). Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. ...
Medicine and evolution, part 13: The fly in the ointment of personalized cancer therapy | ScienceBlogs
Its growth goes from endocrine stimulated to juxtocrine, paracrine, autocrine. Ion communication ports between cells close, ... They are now autocrine in their regulation (regulate themselves) having begun when first transformed as endocrine e.g. ... Please make a tax-deductible donation if you value independent science communication, collaboration, participation, and open ... estradiol from the ovary, then juxstacrine (nearby) paracrine (next door) then autocrine. The exoskeleton by which its cells ...
Seminar - Christian S. Hardtke: Autocrine peptide signals, self-organization and zombie cells: molecular switches in phloem...
Autocrine peptide signals, self-organization and zombie cells: molecular... ... Communication officer. Umeå Plant Science Centre. Email: [email protected] Phone: +46 70 285 6657 ... Autocrine peptide signals, self-organization and zombie cells: molecular switches in phloem formation. Host: Ove Nilsson. Place ... Seminar - Christian S. Hardtke: Autocrine peptide signals, self-organization and zombie cells: molecular switches in phloem ...
In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin
Nov 1, 1997 , Magazine: Biochemical and Biophysical Research Communications Frühbeck G., Aguado M., Martínez J.A.. Department ... In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. ... These in vitro studies suggest an autocrine/paracrine action of leptin on white fat cells and envisages the involvement of the ...
Free Chiropractic Flashcards about Pathology 1 Block 1
communication between two attached celsl. juxtacrine. communication the cell talks to itself. autocrine. ... communication between distant cells. neuroendocrine. Five stages of cellular migration into an inflamed tissue. 1 margination 2 ... Communication between two adjacent cells. gap junctions. ... communication between distant cells endocrine. communication at ...
Butyrate induces apoptosis in murine macrophages via caspase-3, but independent of autocrine synthesis of tumor necrosis factor...
Biochemical and Biophysical Research Communications, 260: 775-780. [ Links ]. 33. Litvak DA, Evers BM, Hwang KO, Hellmich MR, ... Butyrate induces apoptosis in murine macrophages via caspase-3, but independent of autocrine synthesis of tumor necrosis factor ... g and autocrine synthesis of TNF-. a and NO.. The physiologic onset of apoptosis is strictly regulated by ligand receptor ... Biochemical and Biophysical Research Communications, 246: 760-764. [ Links ]. 36. Bauer WR, Hates JJ, White JH & Wolffe AP ( ...
Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production | Nature Communications
Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling | eLife
The stomatal precursor cell uses autocrine peptide-receptor kinase signaling to self-inhibit its differentiation potential in ... Stomatal development: a plants perspective on cell polarity, cell fate transitions and intercellular communication * OS Lau ... B) Autocrine signaling model: Facette and Smith (2012) proposed an alternate, autocrine signaling model based on the ... triggers autocrine inhibition of stomatal fate. During normal stomatal development, this autocrine inhibition prevents extra ...
Autocrine and Paracrine Regulation of the Ovary | Springer for Research & Development
... and autocrine signals. Although many of the factors involved in... ... Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science 2002; 296:2178-80.PubMedCrossRef ... Tesone M., Abramovich D., Irusta G., Parborell F. (2009) Autocrine and Paracrine Regulation of the Ovary. In: Chedrese P. (eds ... Involvement of nerve growth factor in the ovulatory cascade: trkA receptor activation inhibits gap junctional communication ...
Richard Allen Guyer, Ph.D., M.D. | Harvard Catalyst Profiles | Harvard Catalyst
JCI -
CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production
This occurs in the context of T cell-DC communication, during which the DC also delivers costimulatory signals. Immature DCs ... P , 0.01 (t test). (C) Schematic representation of the CD27-driven autocrine pathway for IL-2 production at the tissue site ( ... CD27 mediates effector CD8+ T cell survival via an autocrine IL-2 pathway. Nontransgenic Cd27-/- T cells retrovirally ... CD27 mediates survival at the tissue effector site via an autocrine IL-2 pathway. We next examined whether the IL-2 that is ...
Wang Lab: Cheng Wang PhD
YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression. Oncogene, 2015, 34:6040- ... Narrowly regulated cell-cell communication plays critical role in the follicle cell proliferation, differentiation, ... Delineating the paracrine and autocrine regulation of ovarian function. The basic functional unit of the ovary is the follicle ... These findings bolstered our understanding on the mechanisms underlying the endocrine, paracrine and autocrine regulation of ...
PřF:C8155 Cell signaling - Course Information
Renin-Angiotensin System and Cell Communication in the Failing Heart | Hypertension
Autocrine-paracrine mechanisms of vascular myocytes in systemic hypertension. Am J Cardiol. 1987;60:99I-103I. ... Gap junctional communication in excitable tissues: the heart as a paradigm. Prog Biophys Mol Biol. 1994;61:1-35. ... Effect of intracellular injection of calcium and strontium on cell communication in heart. J Physiol.. 1975;250:231-245. ... For investigation of the role of the RAS on the control of cell communication in the ventricle of CM hamsters, gj was measured ...
Modulation of NK Cell Autocrine-Induced Eosinophil Chemotaxis by Interleukin-15 and Vitamin D3: A Possible NK-Eosinophil...
In the current communication, we demonstrated a novel crosstalk between NK cells and eosinophils via IL-15/IL-8 axis. This may ... These results indicate a novel autocrine activity for NK cells in recruiting eosinophils and highlight a novel role for IL-15 ... Modulation of NK Cell Autocrine-Induced Eosinophil Chemotaxis by Interleukin-15 and Vitamin D3: A Possible NK-Eosinophil ... R. Hoontrakoon, H. C. Chu, J. Gardai et al., "Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine ...
Autocrine Signaling | Protocol (Translated to Chinese)
Autocrine signaling is a form of communication where a cell interacts with itself. It is the signaling and targeted cell, ... 14.2: Autocrine Signaling Secreted signals can act on a variety of target cells. In some cases, the cell that secretes a signal ... Autocrine signaling can also play a role in the development of skin cancer by stimulating the development of new blood vessels ... Autocrine signaling is also a major mechanism of cancer cell proliferation. Cancerous cells secrete a variety of growth signals ...
Cell Communication Flashcards by | Brainscape
Sue E. Huether, Kathryn L. McCance - Test Bank for Understanding Pathophysiology (6th Ed)-TestBank ( - Understanding...
d. communication. ANS: B Conductivity, not sensory interpretation, homeostasis, or communication, is one of the eight chief ... This action is an example of which of the following signaling types? a. Paracrine b. Autocrine c. Neurohormonal d. Hormonal ANS ... REF: p. 10 7. Which form of cell communication is used to relate to other cells in direct physical contact? a. Cell junction b ... Gap junctions allow for cellular communication between cells. Neither desmosomes nor tight junctions are associated with ...
Purinergic signalling - Wikipedia
Autocrine purinergic signalling is an important checkpoint in the activation of white blood cells. These mechanisms either ... It has an excitatory effect on neurones, and acts as a mediator in neuronal-glial communications. Both adenosine and ATP induce ... The release of ATP and an autocrine feedback through P2RY2 and A3 receptors are signal amplifiers. Hypoxia-inducible factors ... Corriden, R.; Insel, P. A. (5 January 2010). "Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation". ...
Frontiers | Cellular and Molecular Networking Within the Ecosystem of Cancer Cell Communication via Tunneling Nanotubes | Cell...
More notably, the transfer of these varied molecules almost invariably plays a critical role in the communication between ... More notably, the transfer of these varied molecules almost invariably plays a critical role in the communication between ... Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. Identification of key cellular ... Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. Identification of key cellular ...
Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and...
The dimensionless group α must exceed unity to allow for autocrine and juxtacrine signaling to occur. The maximal local ... Schematic representation of communication distances, illustrating the definition of the effective communication distance ζ0.5 ... What is required is a definition of an "effective" communication distance. We can define the effective communication distance ... The effective communication distance ζ0.5 is indicated where the c/Km curve at time τ0.5 drops below unity, which occurs at: 14 ...
Chapter 18 part 1.pdf - Chapter 18 The Endocrine System part 1 Activities of the organ systems are coordinated by the nervous...
... of intercellular communication direct communication synaptic communication autocrine communication paracrine communication ... Autocrine communication: chemical signals are released by exocytosis and act on the same cell ... 7/16/2018 4 ENDOCRINE COMMUNICATION endocrine communication: chemical signals, called hormones , are released by exocytosis ... 7/16/2018 3 INTERCELLULAR COMMUNICATION direct communication : ions and small molecules diffuse directly from the cytoplasm of ...
Team:HKUST/Project/Reference - 2010.igem.org
2007). Bacterial communications in implant infections: a target for an intelligence war. Int J Artif Organs. 30(9):757-63. ... Balaban, N., & Novick, R.P. (1995). Autocrine regulation of toxin synthesis by Staphylococcus aureus. Proc Natl Acad Sci U S A ... Balaban, N., & Novick, R.P. (1995). Autocrine regulation of toxin synthesis by Staphylococcus aureus. Proc Natl Acad Sci U S A ...
References Anti-Desmin antibody - Cytoskeleton Marker (ab15200) | Abcam
Li J et al. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-ß signaling. ... Chen J et al. CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl ... Fan J et al. Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine ... Turner CJ et al. Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion. ...
Cell biology - Wikipedia
Communication can occur through direct cell contact or endocrine, paracrine, and autocrine signaling. Direct cell-cell contact ... Autocrine is a cell sending a signal to itself by secreting a molecule that binds to a receptor on its surface. Forms of ... Cell communication is important for cell regulation and for cells to process information from the environment and respond ... cell communication, cell cycle, biochemistry, and cell composition. The study of cells is performed using several techniques ...
Intercellular communicationEndocrineMotility factor receptorRegulationPathwayEndothelial cellsInternal autocrine loop mechanismApoptosisPathwaysReceptorSignalingInhibitionExtracellularReceptorsSignalsActivinVEGFIntracellularCellular communicationCellsSecretionPhysiologicalOvarianProliferationNeuronsHormonesRoleSurvivalCytokinesMonocytesCell Communication
Intercellular communication14
- Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. (frontiersin.org)
- As key mediators of intercellular communication within the tumor ecosystem, TNTs are the central topic of this article. (frontiersin.org)
- One important mode of intercellular communication is the release of soluble cyto- and chemokines. (pnas.org)
- Adenosine triphosphate (ATP) has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles. (mdpi.com)
- Extracellular vesicles (EVs), such as exosomes and microvesicles, play an important autocrine/paracrine role in intercellular communication. (ovid.com)
- In the developed organism, intercellular communication coordinates the activities between multiple cell types and makes organism-wide processes such as immune response, growth, and homeostasis. (healthcanal.com)
- Despite the importance of this process, studies in intercellular communication between specialized cells in higher organisms such as mammals have generally focused on communication between just a few cell types and have been limited in scope to small numbers of ligand-receptor pairs. (healthcanal.com)
- Gap junction channels, formed by connexins, allow the direct intercellular communication between adjacent cells. (physiology.org)
- These stiff, adhesive, trypsin- and RNAse-resistant surface nanofilaments add a new dimension to the current structural knowledge of exosome-mediated intercellular communication. (royalsocietypublishing.org)
- Exosomes are known to play an important role in intercellular communication by extracellular signalling [ 2 ] and horizontal mRNA/microRNA transfer [ 3 ]. (royalsocietypublishing.org)
- We discuss how these newly recognized nanofilaments may help in modulating, tethering and transport of exosomes for intercellular communication. (royalsocietypublishing.org)
- Here, we investigated the involvement of gap junction intercellular communication (GJIC) during anchorage-independent clustering of MCF7 breast adenocarcinoma cells. (biomedcentral.com)
- Q. Hormones are an example of intercellular communication known as _____________ signaling.a. neuralb. (clutchprep.com)
- Loss of gap junction intercellular communication is critical for tumor progression because it allows the tumor cells to escape growth control, invade, and metastasize. (aacrjournals.org)
Endocrine7
- Ovarian follicular development and regression is a continuous and cyclic process that depends on a number of endocrine, paracrine, and autocrine signals. (springer.com)
- These findings bolstered our understanding on the mechanisms underlying the endocrine, paracrine and autocrine regulation of ovarian physiology. (massgeneral.org)
- Decide which of the following forms of human communication are analogous to autocrine, paracine, endocrine , and synaptic signaling. (physicsforums.com)
- Cell communication: types of cellular communication: endocrine, paracrine, autocrine and iuxtacrine. (univr.it)
- The events of early pregnancy are tightly coordinated by means of endocrine, paracrine, juxtacrine, and autocrine cellular communication pathways. (glowm.com)
- In particular, the surfaces of exosomes form fascinating interfaces that may mediate their transport between cells, e.g. both as autocrine and paracrine factors in tumour microenvironments, as well as effectors for distant cellular targets, analogous to endocrine signalling. (royalsocietypublishing.org)
- There are four categories of chemical signaling found in multicellular organisms: paracrine signaling, endocrine signaling, autocrine signaling, and direct signaling across gap junctions. (altwongqq.com)
Motility factor receptor6
- The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. (nature.com)
- Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. (nature.com)
- The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. (nature.com)
- Although AMFR (autocrine motility factor receptor) is well known as a conventional receptor of AMF, which is a protein secreted by tumor cell stimulating tumor motility. (biomedcentral.com)
- Auf www.antikoerper-online.de finden Sie aktuell 65 Autocrine Motility Factor Receptor (AMFR) Antikörper von 18 unterschiedlichen Herstellern. (antikoerper-online.de)
- Huang, Xie, Raz: Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor. (antikoerper-online.de)
Regulation5
- This Review focuses on the roles of autocrine purinergic signalling in the regulation of both innate and adaptive immune responses and discusses the potential of targeting purinergic receptors for treating immune-mediated disease. (nih.gov)
- Autocrine regulation of toxin synthesis by Staphylococcus aureus . (igem.org)
- De-regulation of the autocrine Wnt signaling pathway via mutations in APC and Axin have been linked to activation of various types of human cancer. (wikipedia.org)
- Genetic alterations that lead to de-regulation of the autocrine Wnt pathway result in transactivation of epidermal growth factor receptor (EGFR) and other pathways, in turn contributing to proliferation of tumor cells. (wikipedia.org)
- Ohhara Y, Shimada-Niwa Y, Niwa R , Kayashima Y, Hayashi Y, Akagi K, Ueda H, Yamakawa-Kobayashi K, Kobayashi S. Autocrine regulation of ecdysone synthesis by 3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis. (go.jp)
Pathway5
- Further investigation revealed that mutant EGFR could activate the oncogenic STAT3 pathway via upregulated IL-6 autocrine signaling. (wikipedia.org)
- There is also evidence that glucose, through the hexosamine pathway, can induces autocrine activation of Wnt signalling pathway by stimulating secretion of Wnt proteins. (isciii.es)
- We conclude that IL-3 deprivation activates 24p3 transcription, leading to synthesis and secretion of 24p3, which induces apoptosis through an autocrine pathway. (umassmed.edu)
- A key pathway that allows such communication is gap junction (GJ). (physiology.org)
- In this tumor, the ET-1/ET A R autocrine pathway promotes mitogenesis, apoptosis protection, invasion, and neoangiogenesis. (aacrjournals.org)
Endothelial cells5
- Ang-2 is mainly produced by endothelial cells and therefore acts primarily in an autocrine manner. (biologists.org)
- These interactions include not only cell-to-cell communication among malignant cells, but also interactions between malignant and stromal cells within the extracellular matrix, including vascular endothelial cells and cancer-associated fibroblasts. (frontiersin.org)
- VEGF, produced by carcinoma cells, acts through paracrine signaling on endothelial cells and through autocrine signaling on carcinoma cells. (wikipedia.org)
- CFs interact with not only cardiac myocytes (CMs) but also with other cells in the heart, including vascular endothelial cells (ECs), smooth muscle cells (SMCs), and immune cells, via direct or indirect cellular communications. (rochester.edu)
- Intriguingly, miRNAs can be transferred from cell to cell by exosomes, small vesicles that have been shown to mediate the transfer of proteins and RNAs, thus facilitating the exchange of information among cells this might have important implications in autocrine and paracrine communication between both macrophages and endothelial cells. (yale.edu)
Internal autocrine loop mechanism1
- Taken together, the data demonstrate for the first time the antagonistic Ang-1/Ang-2 concept in a defined cellular model and identify Ang-2 as a rapidly acting autocrine regulator of the endothelium that acts through an internal autocrine loop mechanism. (biologists.org)
Apoptosis2
- On the other hand, IL-15 effect on human eosinophil is through inhibition of the spontaneous apoptosis via the autocrine production of GM-CSF and thus may perpetuate allergic inflammation by prolonged eosinophil survival [ 4 ]. (hindawi.com)
- Genetic alterations, response to growth and inhibitory signals, resistance to apoptosis, myofibroblast origin and behaviour, altered cellular communications, and intracellular signalling pathways are all fundamental pathogenic hallmarks of both IPF and cancer. (ersjournals.com)
Pathways3
- These in vitro studies suggest an autocrine/paracrine action of leptin on white fat cells and envisages the involvement of the OB protein, not only in centrally mediated pathways, but also in physiological functions which take place peripherally. (cun.es)
- SVZ progenitor cells express transcripts for the appropriate BMP-specific type I and II receptor subunits and selective BMP ligands, suggesting the presence of paracrine or autocrine developmental signaling pathways (or both). (elsevier.com)
- ETs and their receptors have been implicated in tumor progression through autocrine and paracrine pathways. (aacrjournals.org)
Receptor7
- We found HGF expression leading to autocrine activation of its receptor tyrosine kinase, MET, in nearly half of the AML cell lines and clinical samples we studied. (nih.gov)
- Our results show a widespread dependence of AML cells on autocrine activation of MET, as well as the key role of compensatory upregulation of HGF expression in maintaining leukemogenic signaling by this receptor. (nih.gov)
- Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. (nature.com)
- Herein, we showed that autocrine motility factor (AMF) binds G protein-coupled estrogen receptor 1 (GPER-1) and then translocates from the plasma membrane to the cytoplasm. (biomedcentral.com)
- In particular, our previous study unveiled the role of GPR30 (now call GPER1), the membrane G protein-coupled estrogen receptor, in mediating the estrogen action during ovarian cell-cell communication and follicle development. (massgeneral.org)
- The group looked at the expression of 1,894 ligand-receptor pairs-based on 642 ligands and 589 receptors-that have been reported in the literature so far, and drew up a large-scale map of cell-to-cell communication between 144 primary human cell types. (healthcanal.com)
- In this process, cell releases chemicals that bind to the autocrine receptor present in the same cell and hence all the required changes take place. (assignmenthelp.net)
Signaling32
- Real-Time Cell Analysis (RTCA) assays were performed to assess whether AMF depends on Autocrine motility factor recepter (AMFR) signaling in EC cells. (biomedcentral.com)
- Autocrine signaling is a form of communication where a cell interacts with itself. (jove.com)
- this is called Autocrine Signaling. (jove.com)
- Under normal physiological conditions, autocrine signaling is important for homeostasis. (jove.com)
- Autocrine signaling is also a major mechanism of cancer cell proliferation. (jove.com)
- Cancerous cells secrete a variety of growth signals to themselves, through autocrine signaling, and to nearby tissues. (jove.com)
- For example, progesterone appears to act in an autocrine manner in breast cancer, whereby progesterone binds to progesterone receptors on the signaling cell, stimulating the action of growth-promoting genes. (jove.com)
- Autocrine signaling can also play a role in the development of skin cancer by stimulating the development of new blood vessels that nourish tumor cells. (jove.com)
- Estimates for the time scale on which signaling takes place and the effective communication distances are needed. (pnas.org)
- Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-ß signaling. (abcam.com)
- PCMO responded to both growth factors in an autocrine fashion with intracellular signaling as evidenced by a rise in the levels of phospho-Smad2 and a drop in those of phospho-Smad3. (nih.gov)
- Inhibition of autocrine activin signaling by either SB431542 or follistatin reduced both Smad2 activation and Oct4A/Nanog upregulation. (nih.gov)
- Inhibition of autocrine TGF-β signaling by either SB431542 or anti-TGF-β antibody reduced Smad3 activation and strongly increased the number of Ki67-positive cells. (nih.gov)
- Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell. (wikipedia.org)
- Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors. (wikipedia.org)
- Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. (wikipedia.org)
- Their research showed that autocrine IL-6 signaling induced malignant features in Notch-3 expressing mammospheres. (wikipedia.org)
- Another agent involved in autocrine cancer signaling is vascular endothelial growth factor (VEGF). (wikipedia.org)
- One study showed that autocrine PDGFR signaling plays an essential role in epithelial-mesenchymal transition (EMT) maintenance in vitro, which is known to correlate well with metastasis in vivo. (wikipedia.org)
- The authors showed that the metastatic potential of oncogenic mammary epithelial cells required an autocrine PDGF/PDGFR signaling loop, and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. (wikipedia.org)
- D) talking to yourself: This would be autocrine signaling. (physicsforums.com)
- In autocrine signaling the signaling and target cell are physically the same. (physicsforums.com)
- The process requires innate response activator (IRA) B cells, a transitional B1a-derived inflammatory subset which controls IgM production via autocrine granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. (rupress.org)
- Defects in cell-cell communication, including the dysregulation of autocrine signaling, are also implied in the development of cancer, and autoimmune and metabolic diseases. (healthcanal.com)
- Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. (thefullwiki.org)
- Here we review applications of several of these approaches, including principal component analysis, partial least squares regression, partial least squares discriminant analysis, decision trees, and Bayesian networks, and describe the advances they have offered in systems-level understanding of immune cell signaling and communication. (springer.com)
- This makes IGF-1 a good protagonist at targeting tissues to spur cell to cell communication (growth) or in a more autocrine cell signaling process that facilitates cell division. (burrillandco.com)
- Peptide hormone are other class of signaling molecule produced mostly in animals that helps in the cell- cell communication. (assignmenthelp.net)
- These are lipid signaling molecules that are readily broken down to act either in autocrine or paracrine manner. (assignmenthelp.net)
- These results suggested that the tumor cells stimulated their growth through an activin A autocrine signaling pathwa, a hypothesis confirmed by activin A secretion in cultured GCT cells which proliferated in response. (aacrjournals.org)
- However, HPV16 VLP-stimulated IL-12 production by CD8α + CD11c + DCs is augmented by autocrine IFN-γ signaling. (elsevier.com)
- Cell signaling is the process of cellular communication within the body driven by cells releasing and receiving hormones and other signaling molecules. (altwongqq.com)
Inhibition2
- The absolute co-expression of ERL1 and MUTE, with the co-presence of EPF1, triggers autocrine inhibition of stomatal fate. (elifesciences.org)
- During normal stomatal development, this autocrine inhibition prevents extra symmetric divisions of stomatal precursors likely owing to excessive MUTE activity. (elifesciences.org)
Extracellular2
- Recent work has shown that autocrine signalling is an important checkpoint in immune cell activation and allows immune cells to adjust their functional responses based on the extracellular cues provided by their environment. (nih.gov)
- Extracellular AMP is hydrolyzed to adenosine by ecto-5'-nucleotidase (eN) as well as by APs. (wikipedia.org)
Receptors3
- Stimulation of almost all mammalian cell types leads to the release of cellular ATP and autocrine feedback through a diverse array of purinergic receptors. (nih.gov)
- Depending on the types of purinergic receptors that are involved, autocrine signalling can promote or inhibit cell activation and fine-tune functional responses. (nih.gov)
- Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss. (burrillandco.com)
Signals3
- This occurs in the context of T cell-DC communication, during which the DC also delivers costimulatory signals. (jci.org)
- There are signals set by scientist that makes the process of communication easy and effective. (assignmenthelp.net)
- and direct communication, which means signals pass inside the cell itself. (altwongqq.com)
Activin1
- Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β. (nih.gov)
VEGF3
- Evidence shows that autocrine VEGF is involved in two major aspects of invasive carcinoma: survival and migration. (wikipedia.org)
- siRNA-based suppression of VEGF expression in a Müller cell line in vitro supports the existence of an autocrine role for VEGF in Müller cell survival.These results indicate an important role for endogenous VEGF in the maintenance and function of adult retina neuronal cells and indicate that anti-VEGF therapies should be administered with caution. (nih.gov)
- siRNA-based suppression of VEGF expression in a Müller cell line in vitro supports the existence of an autocrine role for VEGF in Müller cell survival. (nih.gov)
Intracellular2
- Intracellular dialysis of Ang I (10 −8 mol/L) abolished cell communication in myopathic cell pairs with low gj (0.8 to 2.5 nS) and reduced gj by 66±1.7% in the other pairs (7 to 35 nS). (ahajournals.org)
- Nitric oxide (NO) acts as an autocrine and paracrine mediator in the inter- and intracellular communication between various cell systems. (uni-halle.de)
Cellular communication4
- Gap junctions allow for cellular communication between cells. (coursehero.com)
- Neither desmosomes nor tight junctions are associated with cellular communication. (coursehero.com)
- Cellular communication is a critical component of heterotypic and homotypic interactions in the complex, ever-changing tumor microenvironment. (frontiersin.org)
- Gap junction proteins are integral membrane proteins present in both vertebrates and invertebrates that participate in cellular communication. (intechopen.com)
Cells14
- Which form of cell communication is used to relate to other cells in direct physical contact? (coursehero.com)
- More notably, the transfer of these varied molecules almost invariably plays a critical role in the communication between cancer cells themselves in an effort to resist death by chemotherapy and promote the growth and metastases of the primary oncogenic cell. (frontiersin.org)
- Cell biology encompasses both prokaryotic and eukaryotic cells and can be divided into many sub-topics which may include the study of cell metabolism, cell communication, cell cycle, biochemistry, and cell composition. (wikipedia.org)
- Paracrine communication involves chemical messengers between cells within one tissue. (scribd.com)
- Autocrine cells act on the same cell that produced them. (scribd.com)
- Cells communicate in ways that are analogous to human communication. (physicsforums.com)
- Paracrine communication involves local diffusion of regulators from producer cells to distinct target cells within the same organ. (glowm.com)
- This process is particularly critical during early embryonic development when a cell's differentiation and ultimate fate are controlled by communication with neighboring cells. (healthcanal.com)
- In their struggle to survive and prosper, multicellular organisms rely on a complex network of communication between cells, which in humans are believed to number about 40 trillion. (riken.jp)
- Neurons are the cells within the brain that are responsible for rapid communication of information. (thefreelibrary.com)
- The regulatory response conditions involving IL10 can act in an autocrine manner to suppress the activity of NK cells, macrophages and Th1 cells, all of which are obligatory for pathogen clearance can add to tissue injury. (sciencemag.org)
- Here, we report that uncontrolled PI3K activity within oocytes irreversibly transforms granulosa cells (GC), causing GC tumors (GCT) through perturbed local cell-communication. (aacrjournals.org)
- Although communication between the oocyte and surrounding somatic cells is critical for the normal development of ovarian follicles, perturbations in oocyte-GC communication during early folliculogenesis can induce GCT by activating an autocrine growth circuit program in GC. (aacrjournals.org)
- Q. Communication between cells can occur by all of the following basic mechanisms excepta. (clutchprep.com)
Secretion3
- Respiration ANS: D NURSINGTB.COM The cell's ability to absorb oxygen is referred to as respiration while its communication ability involves maintenance of a steady dynamic state, metabolic absorption provides nutrition, and secretion allows for the synthesizing of new substances. (coursehero.com)
- This mode of communication is governed both by physicochemical transport processes and cellular secretion rates, which in turn are determined by genetic and biochemical processes. (pnas.org)
- Recent research revealed that IL-6 secretion induced by HER2 overexpression activated STAT3 and altered gene expression, resulting in an autocrine loop of IL-6/STAT3 expression. (wikipedia.org)
Physiological1
- Cell-to-cell communication is a process necessary for physiological tissue homeostasis and appears often altered during disease. (physiology.org)
Ovarian1
- The ovarian follicle plays an essential role in securing optimal conditions for oocyte maturation and its release during ovulation, for which it will provide an appropriate microenvironment based on locally produced molecules, such as sex steroids and peptide hormones, growth factors, and cytokines, while also providing the appropriate communication among particular compartments of an ovarian follicle [ 3 - 5 ]. (intechopen.com)
Proliferation1
- Narrowly regulated cell-cell communication plays critical role in the follicle cell proliferation, differentiation, steroidogenesis, oocyte maturation and ovulation. (massgeneral.org)
Neurons1
- Also, neurons have been identified that use zinc release for synaptic communication. (pubmedcentralcanada.ca)
Hormones1
- This article will focus on the basic processes underlying neuronal communication and review the neuronal actions of several neurotransmitters, neurotrophic factors, and hormones thought to be involved in the neural actions of alcohol. (thefreelibrary.com)
Role1
- 23 Previous studies 24 indicated that the RAS plays an important role in the modulation of cell-to-cell communication in normal rat heart. (ahajournals.org)
Survival2
- Competition experiments showed that the IL-2 produced under the control of CD27 supported effector CD8 + T cell survival in the lungs in an autocrine manner. (jci.org)
- One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. (wikipedia.org)
Cytokines1
- During bacterial, viral and protozoal infection, the communication between PAMPs and PRRs of APCs directs the development of Th1, Th2 and Treg cell populations, depending on cytokines, chemokine environment and state of co-stimulation. (sciencemag.org)
Monocytes1
- An example of an autocrine agent is the cytokine interleukin-1 in monocytes. (wikipedia.org)
Cell Communication7
- Abstract The influence of heart failure on the process of cell communication was investigated in cell pairs isolated from the ventricle of cardiomyopathic hamsters (11 months old) and the results compared with age-matched normal hamsters. (ahajournals.org)
- However, the underlying molecular mechanisms, cell-cell communication, and autocrine/paracrine factors involved in cellular interplay are largely unknown. (rochester.edu)
- Besides glucose, the major nutrient factor, inputs from neural and humoral components and intraislet cell-cell communication act together to guarantee an appropriate pancreatic beta-cell function. (nih.gov)
- Some cell-to-cell communication requires direct cell-cell contact . (thefullwiki.org)
- Looking forward, new experimental technologies involving single-cell measurements of cytokine expression beckon extension of these modeling techniques to inference of immune cell-cell communication networks, with a goal of aiding development of improved vaccine therapeutics. (springer.com)
- What are the steps of cell communication? (altwongqq.com)
- What are the three types of cell communication? (altwongqq.com)