AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
Autocrine CommunicationCommunicationCell CommunicationAnimal CommunicationCommunication DisordersHealth CommunicationCommunication Aids for DisabledNonverbal CommunicationParacrine CommunicationCommunication BarriersPhysician-Patient RelationsComputer Communication NetworksConnexin 43Radiology Information SystemsReceptors, Autocrine Motility FactorSignal TransductionHospital Communication SystemsInterdisciplinary CommunicationCell DivisionCells, CulturedRNA, MessengerCommunication Methods, TotalConnexinsProfessional-Patient RelationsCommunications MediaGlucose-6-Phosphate IsomeraseTumor Cells, CulturedTransforming Growth Factor alphaProfessional-Family RelationsGrowth SubstancesElectronic MailInterprofessional RelationsPersuasive CommunicationPatient SatisfactionTape RecordingVocalization, AnimalCulture Media, ConditionedNurse-Patient RelationsCell LineAttitude of Health PersonnelInternetTelecommunicationsTransforming Growth Factor betaPatient SimulationRole PlayingReverse Transcriptase Polymerase Chain ReactionTeleradiologyQuestionnairesTime FactorsModels, BiologicalGene Expression
Autocrine Communication
Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone.
Communication
The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.
Cell Communication
Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.
Animal Communication
Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.
Communication Disorders
Disorders of verbal and nonverbal communication caused by receptive or expressive LANGUAGE DISORDERS, cognitive dysfunction (e.g., MENTAL RETARDATION), psychiatric conditions, and HEARING DISORDERS.
Health Communication
The transfer of information from experts in the medical and public health fields to patients and the public. The study and use of communication strategies to inform and influence individual and community decisions that enhance health.
Communication Aids for Disabled
Equipment that provides mentally or physically disabled persons with a means of communication. The aids include display boards, typewriters, cathode ray tubes, computers, and speech synthesizers. The output of such aids includes written words, artificial speech, language signs, Morse code, and pictures.
Nonverbal Communication
Transmission of emotions, ideas, and attitudes between individuals in ways other than the spoken language.
Paracrine Communication
Cellular signaling in which a factor secreted by a cell affects other cells in the local environment. This term is often used to denote the action of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS on surrounding cells.
Communication Barriers
Those factors, such as language or sociocultural relationships, which interfere in the meaningful interpretation and transmission of ideas between individuals or groups.
Physician-Patient Relations
The interactions between physician and patient.
Computer Communication Networks
A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)
Connexin 43
A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.
Radiology Information Systems
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.
Receptors, Autocrine Motility Factor
Cell surface receptors for AUTOCRINE MOTILITY FACTOR, which is the secreted form of GLUCOSE-6-PHOSPHATE ISOMERASE. The receptor has an unusual composition in that it shares some structural similarities with G-PROTEIN-COUPLED RECEPTORS and functions as an ubiquitin protein ligase when internalized.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Hospital Communication Systems
The transmission of messages to staff and patients within a hospital.
Interdisciplinary Communication
Communication, in the sense of cross-fertilization of ideas, involving two or more academic disciplines (such as the disciplines that comprise the cross-disciplinary field of bioethics, including the health and biological sciences, the humanities, and the social sciences and law). Also includes problems in communication stemming from differences in patterns of language usage in different academic or medical disciplines.
Cell Division
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Communication Methods, Total
Utilization of all available receptive and expressive modes for the purpose of achieving communication with the hearing impaired, such as gestures, postures, facial expression, types of voice, formal speech and non-speech systems, and simultaneous communication.
Connexins
A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.
Professional-Patient Relations
Interactions between health personnel and patients.
Communications Media
The means of interchanging or transmitting and receiving information. Historically the media were written: books, journals, newspapers, and other publications; in the modern age the media include, in addition, radio, television, computers, and information networks.
Glucose-6-Phosphate Isomerase
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Tumor Cells, Cultured
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Transforming Growth Factor alpha
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.
Professional-Family Relations
The interactions between the professional person and the family.
Growth Substances
Signal molecules that are involved in the control of cell growth and differentiation.
Electronic Mail
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Interprofessional Relations
The reciprocal interaction of two or more professional individuals.
Persuasive Communication
A mode of communication concerned with inducing or urging the adoption of certain beliefs, theories, or lines of action by others.
Patient Satisfaction
The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.
Tape Recording
Recording of information on magnetic or punched paper tape.
Vocalization, Animal
Sounds used in animal communication.
Culture Media, Conditioned
Culture media containing biologically active components obtained from previously cultured cells or tissues that have released into the media substances affecting certain cell functions (e.g., growth, lysis).
Nurse-Patient Relations
Interaction between the patient and nurse.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Attitude of Health Personnel
Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.
Internet
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Telecommunications
Transmission of information over distances via electronic means.
Transforming Growth Factor beta
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Patient Simulation
The use of persons coached to feign symptoms or conditions of real diseases in a life-like manner in order to teach or evaluate medical personnel.
Role Playing
The adopting or performing the role of another significant individual in order to gain insight into the behavior of that person.
Reverse Transcriptase Polymerase Chain Reaction
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Teleradiology
The electronic transmission of radiological images from one location to another for the purposes of interpretation and/or consultation. Users in different locations may simultaneously view images with greater access to secondary consultations and improved continuing education. (From American College of Radiology, ACR Standard for Teleradiology, 1994, p3)
Questionnaires
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Models, Biological
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Gene Expression
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. (1/1262)

The EPH family is the largest subfamily of receptor protein tyrosine kinases, consisting of the EPHA and EPHB subgroups. Ephrin-B1, ephrin-B2, and ephrin-B3 are ligands of the EPHB subgroup and are encoded by the EFNB1, EFNB2, and EFNB3 genes, respectively. We have shown previously that EPHB2 transcripts are expressed in six small cell lung carcinoma (SCLC) cell lines. In this study, we examined the expression of EPHB1, EPHB2, EPHB3, EPHB4, and EPHB6 in 4 SCLC tumor specimens and 14 cell lines including 3 cell lines derived from these tumor specimens. To investigate whether potential autocrine loops of EPHB receptors and ephrin-B ligands exist in SCLC, the expression of EFNB1, EFNB2, and EFNB3 was also examined. Our data show that transcripts encoding multiple members of the EPHB subgroup and the ephrin-B subgroup are coexpressed in SCLC cell lines and tumors. These results suggest that the EPHB subgroup receptor kinases may modulate the biological behavior of SCLC through autocrine and/or juxtacrine activation by ephrin-B ligands that are expressed in the same or neighboring cells.  (+info)

Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. (2/1262)

The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by influenza virus infection and by double-stranded (ds)RNA. This activation results not only in increased antigen presentation and T cell stimulatory capacity, but also in resistance to the cytopathic effect of the virus, mediated by the production of type I interferon, and upregulation of MxA. Because dsRNA stimulates both maturation and resistance, DCs can serve as altruistic antigen-presenting cells capable of sustaining viral antigen production while acquiring the capacity to trigger naive T cells and drive polarized T helper cell type 1 responses.  (+info)

Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1alpha. (3/1262)

PURPOSE: The matrix metalloproteinase gelatinase B is synthesized by cells at the leading edge of the corneal epithelium migrating to heal a wound. Recent data from the authors' laboratory suggest that excessive synthesis contributes to repair defects. The goal of the study reported here was to investigate mechanisms controlling gelatinase B production by corneal epithelial cells. METHODS: Freshly isolated cultures of corneal epithelial cells and early passage stromal fibroblasts from rabbit were used for these studies. RESULTS: In a previous study, it was found that the cytokine interleukin (IL)-1alpha is released into the culture medium of corneal epithelial cells more efficiently when they are plated at low density with limited cell-cell contact than when plated at high density. In this study, we show that production of gelatinase B by these cells is similarly affected by cell plating density. However, it is further demonstrated that these two events are not dependent on one another but occur in parallel: IL-1alpha does not regulate gelatinase B production (synthesis), nor was there evidence that any other secreted autocrine cytokine acts as mediator. Instead, our data suggest that gelatinase B production is downregulated directly by high cell density and indicate a connection to the level of protein kinase C activity. Nevertheless, the anticancer agent suramin, which blocks collagenase synthesis by interfering with autocrine cytokine-receptor interactions, still inhibits synthesis of gelatinase B. CONCLUSIONS: Unlike collagenase synthesis by corneal stromal fibroblasts, production (synthesis) of gelatinase B does not appear to be controlled by secreted autocrine cytokines but can still be inhibited by suramin. Suramin may make an effective therapeutic agent for controlling pathologic overproduction of gelatinase B in corneal ulcers.  (+info)

Pituitary adenylate cyclase-activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells. (4/1262)

There is increasing evidence that hormones play an important role in the control of endothelial cell function and growth by regulating the production of vascular endothelial growth factor (VEGF). VEGF regulates vascular permeability and represents the most powerful growth factor for endothelial cells. In the normal anterior pituitary, VEGF has been detected only in folliculostellate (FS) cells. In the present study, the regulation of the release of VEGF from FS-like mouse TtT/GF cells, and from FS cells of rat pituitary monolayer cell cultures was investigated using a specific VEGF ELISA. Basal release of VEGF was demonstrated in cultures of both TtT/GF cells and rat pituitary cells. Interestingly, the VEGF secretion was stimulated by both forms of pituitary adenylate cyclase-activating polypeptide (PACAP-38 and PACAP-27), indicating that this hypothalamic peptide regulates endothelial cell function and growth within the pituitary. VEGF secretion was also stimulated by interleukin-6 (IL-6) whereas basal, IL-6- and PACAP-stimulated secretion was inhibited by the synthetic glucocorticoid dexamethasone. The inhibitory action of dexamethasone was reversed by the glucocorticoid receptor antagonist RU486, suggesting that in FS cells functional glucocorticoid receptors mediate the inhibitory action of glucocorticoids on the VEGF secretion. The endocrine and auto-/paracrine control of VEGF production in pituitary FS cells by PACAP, IL-6 and glucocorticoids may play an important role both in angiogenesis and vascular permeability regulation within the pituitary under physiological and pathophysiological conditions.  (+info)

Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets. (5/1262)

We compared several responses in thrombin-stimulated and collagen (type I)-stimulated platelets with and without forskolin and inhibitors of autocrine stimulation (IAS: an ADP-removing system of creatine phosphate/creatine phosphokinase, Arg-Gly-Asp-Ser peptide to prevent fibrinogen/fibronectin binding to GPIIb/IIIa, SQ 29.548 as a thromboxane A2 receptor antagonist, cyproheptadine as a serotonin receptor antagonist, BN 52021 as a platelet-activating factor receptor antagonist). The pattern of tyrosine-phosphorylated proteins, the phosphorylation of lipids in the polyphosphoinositide cycle and phosphorylation of pleckstrin (P47) were studied as markers for signal-transducing responses, exposure of CD62 (P-selectin) and CD63 (Glycoprotein 53), as well as secretion of ADP + ATP and beta-N-acetyl-glycosaminidase were studied as final activation responses. Clear differences between thrombin-stimulated and collagen-stimulated platelets were observed. First, practically all protein-tyrosine phosphorylation induced by thrombin was inhibited by IAS, while a partial inhibition was observed for collagen; the phosphorylation due to collagen alone was apparently stimulated by elevation of cAMP. Secondly, the other responses to thrombin were inhibited by increased levels of cAMP, independent of autocrine stimulation. In contrast, only the autocrine part of the collagen-induced responses was inhibited by elevation of cAMP. Thus, the inhibition by elevated cAMP seen in collagen-stimulated platelets seems to be due to removal of the G-protein-mediated activation from secreted autocrine stimulators either by IAS or forskolin. The remaining activity is a pure collagen effect which is not affected by elevated levels of cAMP.  (+info)

Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid. (6/1262)

PURPOSE: Expression of the genes for collagenase and interleukin-1alpha (IL-1alpha) are induced as stromal cells become activated to the repair fibroblast phenotype after injury to the cornea. This investigation examines the mechanisms whereby expression of these genes is inhibited by transforming growth factor-beta (TGF-beta), dexamethasone (DEX), or retinoic acid (RET A). METHODS: A model of freshly isolated cultures of corneal stromal cells and early passage cultures of corneal fibroblasts was used in these studies. This model reproduces the events of stromal cell activation in the corneal wound. RESULTS: In early passage cultures of corneal fibroblasts, expression of collagenase is under obligatory control by autocrine IL-1alpha. IL-1alpha controls its own expression through an autocrine feedback loop that is dependent on transcription factor NF-kappaB. TGF-beta, DEX, and RET A were each effective inhibitors of collagenase gene expression in these cells. Furthermore, these agents have the capacity to inhibit expression of IL-1alpha and this was correlated with their ability to affect DNA-binding activity of NF-kappaB. However, TGF-beta, DEX, and RET A were also effective inhibitors of the low level of collagenase expressed by freshly isolated corneal stromal cells that cannot express IL-1alpha. CONCLUSIONS: In cells with an active IL-1alpha autocrine loop there are at least two distinct signaling pathways by which collagenase gene expression can be modulated. The results of this study demonstrate that TGF-beta, DEX, and RET A differentially inhibit collagenase and IL-1alpha gene expression. This information will be useful in the design of therapeutic modalities for fibrotic disease in the cornea and other parts of the eye.  (+info)

The role of macrophage cell death in tuberculosis. (7/1262)

Studies of host responses to infection have traditionally focused on the direct antimicrobial activity of effector molecules (antibodies, complement, defensins, reactive oxygen and nitrogen intermediates) and immunocytes (macrophages, lymphocytes, and neutrophils among others). The discovery of the systems for programmed cell death of eukaryotic cells has revealed a unique role for this process in the complex interplay between microorganisms and their cellular targets or responding immunocytes. In particular, cells of the monocyte/macrophage lineage have been demonstrated to undergo apoptosis following intracellular infection with certain pathogens that are otherwise capable of surviving within the hostile environment of the phagosome or which can escape the phagosome. Mycobacterium tuberculosis is a prototypical 'intracellular parasite' of macrophages, and the direct induction of macrophage apoptosis by this organism has recently been reported from several laboratories. This paper reviews the current understanding of the mechanism and regulation of macrophage apoptosis in response to M. tuberculosis and examines the role this process plays in protective immunity and microbial virulence.  (+info)

Ligation of Fc gamma RII (CD32) pivotally regulates survival of human eosinophils. (8/1262)

The low-affinity IgG Fc receptor, FcgammaRII (CD32), mediates various effector functions of lymphoid and myeloid cells and is the major IgG Fc receptor expressed by human eosinophils. We investigated whether FcgammaRII regulates both cell survival and death of human eosinophils. When cultured in vitro without growth factors, most eosinophils undergo apoptosis within 96 h. Ligation of FcgammaRII by anti-CD32 mAb in solution inhibited eosinophil apoptosis and prolonged survival in the absence of growth factors. Cross-linking of human IgG bound to FcgammaRII by anti-human IgG Ab or of unoccupied FcgammaRII by aggregated human IgG also prolonged eosinophil survival. The enhanced survival with anti-CD32 mAb was inhibited by anti-granulocyte-macrophage-CSF (GM-CSF) mAb, suggesting that autocrine production of GM-CSF by eosinophils mediated survival. In fact, mRNA for GM-CSF was detected in eosinophils cultured with anti-CD32 mAb. In contrast to mAb or ligands in solution, anti-CD32 mAb or human IgG, when immobilized onto tissue culture plates, facilitated eosinophil cell death even in the presence of IL-5. Cell death induced by these immobilized ligands was accompanied by DNA fragmentation and was inhibited when eosinophil beta2 integrin was blocked by anti-CD18 mAb, suggesting that beta2 integrins play a key role in initiating eosinophil apoptosis. Thus, FcgammaRII may pivotally regulate both survival and death of eosinophils, depending on the manner of receptor ligation and beta2 integrin involvement. Moreover, the FcgammaRII could provide a novel mechanism to control the number of eosinophils at inflammation sites in human diseases.  (+info)

TNF-α Autocrine Feedback Loops in Human Monocytes: The Pro- and Anti-Inflammatory Roles of the TNF-α Receptors Support the...TNF-α Autocrine Feedback Loops in Human Monocytes: The Pro- and Anti-Inflammatory Roles of the TNF-α Receptors Support the...
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
https://www.hindawi.com/journals/jir/2016/1079851/
Sulf-2 knockdown effect on autocrine Wnt signaling (a) | Open-iSulf-2 knockdown effect on autocrine Wnt signaling (a) | Open-i
Sulf-2 knockdown effect on autocrine Wnt signaling (a) H292, Calu6, and P-ST cells were transfected with TOP/FOP flash reporter system, then cultured in presenc
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2818095_nihms141344f6&req=4
Nitric oxide but not prostacyclin has an autocrine function in porcine aortic endothelial cells. - Fingerprint - Experts...Nitric oxide but not prostacyclin has an autocrine function in porcine aortic endothelial cells. - Fingerprint - Experts...
Dive into the research topics of Nitric oxide but not prostacyclin has an autocrine function in porcine aortic endothelial cells.. Together they form a unique fingerprint. ...
https://experts.umn.edu/en/publications/nitric-oxide-but-not-prostacyclin-has-an-autocrine-function-in-po/fingerprints/
IGFBP3 and IGFBP2 negatively and positively modulate IGFs autocrine effect in lung cancer cell lines | ECE2009IGFBP3 and IGFBP2 negatively and positively modulate IGFs autocrine effect in lung cancer cell lines | ECE2009
Insulin-like growth factors (IGFs) play an important role in the pathogenesis of several neoplasias and the IGF-binding proteins (IGFBPs) may have a role as autocrine/paracrine factors in regulating the local actions of the IGFs. In the present study we investigated IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3 production in cultured media from three human lung cancer cell lines (Calu-3, Calu-6, A549) and in human neoplastic and normal lung tissue samples obtained at surgery from 8 patients. Calu-6 cells secreted much more IGF-II than Calu-3 and A549 (190, 25, and 5 ng/107 cells respectively) and much less IGF-I (0.7, 13, and 5 ng/107 cells). Conversely, IGFBP-1 and IGFBP-3 were most abundant in media conditioned by CALU-3 (13 and 120 ng/107 cells respectively) and least abundant in CALU-6 (,1 ng/107 cells). Molar ratio between IGF-I+IGF-II and IGFBP-1+IGFBP-3 was much higher in Calu-6 which is also the most actively replicating cell line. Regarding IGFBP-2 we found a higher concentration in ...
https://www.endocrine-abstracts.org/ea/0020/ea0020p540.htm
IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential...IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential...
The cytokine IL-15 appears to mimic the stimulatory activity of IL-2 on lymphocytes by utilizing part of the IL-2R complex. Although effects of IL-15 on Mphi activities have not previously been reported, its derivation from activated Mphi suggested a possible autocrine role in regulating Mphi functions and prompted us to determine whether IL-15 modulated LPS-activated Mphi cytokine production. Whereas high IL-15 concentrations enhanced proinflammatory (i.e., TNF-alpha, IL-1, and IL-6) and anti-inflammatory (i.e., IL-10) cytokine production by two- to sixfold, extremely low IL-15 concentrations (picomolar to attomolar range) markedly and selectively suppressed Mphi proinflammatory, but not anti-inflammatory, cytokine production by two- to fourfold. The stimulation (but not the suppression) of TNF-alpha production by IL-15 required the (IL-2/IL-15) receptor beta chain, as demonstrated by receptor subunit-blocking studies and lack of stimulation of Mphi from IL-2Rbeta-deficient mice. Conversely, ...
https://www.jimmunol.org/content/159/6/2941
Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical...Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical...
Spontaneous interleukin-6 (IL-6) production has been observed in various tumors and implicated in the pathogenesis, progression and drug resistance in cancer. However, the regulation of IL-6 autocrine production in cancer cells is not fully understood. IL-6 is auto-regulated in many types of cell. Two of the three major downstream pathways of IL-6, MEK/extracellular signal-related kinase (Erk) pathway and phosphatidylinositol 3-kinase (PI3-K)/Akt pathway, have been shown to regulate IL-6 expression through the activation of AP-1 and NF-κB. However, it is not clear what the role of Janus kinase (Jak) 2/signal transducer and activator of transcription (Stat) 3 pathway. This study was designed to determine the role of Jak2/Stat3 pathway in the regulation of IL-6 autocrine production in cancer cells. Inhibitors of Jak2/Stat3, MEK/Erk and PI3-K/Akt pathways down-regulated IL-6 secretion in the lung adenocarcinoma PC14PE6/AS2 (AS2) cells, which spontaneously secreted IL-6 and possessed constitutively
https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-9-309/figures/3
Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid...Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid...
IL-8 is overexpressed in multiple cancer types where it promotes the acquisition of mesenchymal features, stemness, resistance to therapies, and the recruitment of immune-suppressive cells to the tumor site. Through an autocrine feedback loop, IL-8 maintains the mesenchymal phenotype of tumor cells by further upregulating IL-8 and IL-8R, as well as inducing adjacent cells to undergo EMT in a paracrine mode within the tumor TME [4]. Studies in preclinical models and clinical trials have shown that antibody blockade of IL-8 produces positive effects in both non-malignant inflammatory conditions and cancer [7, 23, 27]. We have previously shown that HuMax-IL8 can revert mesenchymalization in triple negative breast cancer models both in vitro and in vivo as well as significantly decrease the recruitment of polymorphonuclear MDSCs at the tumor site, an effect substantiated when used in combination with docetaxel. HuMax-IL8 was also shown to enhance the susceptibility of breast cancer cells to ...
https://jitc.bmj.com/content/7/1/240?ijkey=51239d0c3036bc2209cc59f15f6ec1f2195ac668&keytype2=tf_ipsecsha
Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in...Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/7588299?dopt=Abstract
The contribution of vitamin A to autocrine regulation of fat depotsThe contribution of vitamin A to autocrine regulation of fat depots
Morbidity and mortality associated with increased white fat accumulation in visceral fat depots have focused attention on the pathways regulating the development of this tissue during embryogenesis, in adulthood, and while under the influence of obesogenic diets. Adipocytes undergo clonal expansion, …
https://pubmed.ncbi.nlm.nih.gov/21704731/?dopt=Abstract
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Here, we demonstrated that depolarization of DMH neurons triggers the somatodendritic release of CCK, which acts as an autocrine signal to enhance NMDAR function and liberate NO. Subsequent retrograde NO signaling stimulates the release of GABA from presynaptic terminals in the DMH. These observations provide two critical pieces of information: first, they provide, to the best of our knowledge, the first report of somatodendritic release of the neuropeptide CCK in the brain. Second, they describe a novel form of synaptic regulation in which postsynaptic depolarization enhances synaptic inhibition. The latter observation is particularly intriguing because it provides an example of a feedback system in which a neuron quenches its own excitability by increasing the release of GABA from its afferents. This stands in contrast to the widespread inhibition of neurotransmitter release reported in multiple brain regions following postsynaptic depolarization and the subsequent liberation of eCBs (Wilson ...
http://www.jneurosci.org/content/35/38/13160
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Whereas angiogenesis presents many potential therapeutic targets, the VEGFR2 signal pathway has emerged as a primary paracrine/autocrine regulator of endothelial cell biology (18-20). Preclinical studies show that pazopanib is a potent inhibitor of all three VEGF receptors in vitro and that it inhibits HUVEC proliferation in response to VEGF. Although pazopanib is ,30-fold selective for VEGF-induced endothelial cell proliferation compared with that induced by bFGF, it inhibits both VEGF- and bFGF-mediated angiogenesis in vivo. This apparent paradox can be explained by earlier observations that bFGF induces VEGF production in endothelial and other stromal cells (18) and that anti-VEGF antibody can block angiogenesis induced by bFGF in the Matrigel plug assay (data not shown). Pazopanib inhibits the growth of a broad range of human tumor xenografts in mice, and a single p.o. dose of 30 mg/kg inhibits VEGF-induced VEGFR2 phosphorylation in vivo.. We hoped to use data obtained from preclinical ...
https://mct.aacrjournals.org/content/6/7/2012
Immune cell regulation by autocrine purinergic signallingImmune cell regulation by autocrine purinergic signalling
Stimulation of almost all mammalian cell types leads to the release of cellular ATP and autocrine feedback through a diverse array of purinergic receptors. Depending on the types of purinergic receptors that are involved, autocrine signalling can promote or inhibit cell activation and fine-tune func …
https://pubmed.ncbi.nlm.nih.gov/21331080/
People - Cell Biology and Physiology - UNC School of MedicinePeople - Cell Biology and Physiology - UNC School of Medicine
Research: hormone/paracrine/autocrine regulation of the renal microcirculation, calcium signaling in vascular smooth muscle cells, pathophysiology of hypertension ...
http://www.med.unc.edu/cellbiophysio/people
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Under serum-free conditions, malignant RMS cells maintain proliferation through autocrine mechanisms (21 , 57 , 59) and exhibit a relatively low level of spontaneous apoptosis, similar to that observed when cells are cultured under serum-containing conditions. These malignant cells differ, therefore, from several nonmalignant cell types, which undergo apoptosis under conditions of serum withdrawal. We showed previously that rapamycin potently induces growth arrest in Rh1 and Rh30 RMS cells under these conditions of culture. However, in the presence of serum, Rh1 cells were highly resistant to growth inhibition by rapamycin. Consequently, it was of interest to determine which components in serum protected these cells. We found that, under serum-free conditions of growth, IGF-I completely substituted for serum in causing rapamycin resistance in Rh1 cells. Exogenous IGF-I abrogated growth arrest in Rh1 cells, whereas Rh30 cells remained arrested even in the presence of IGF-I. Rescue was not due to ...
http://cancerres.aacrjournals.org/content/59/4/886
Autocrine signaling in 3 dimensions | PRiME portalAutocrine signaling in 3 dimensions | PRiME portal
A model of autocrine signaling in cultures of suspended cells was developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime were derived. Interferon signaling by dendritic immune cells were considered as an illustration ...
http://tsb.mssm.edu/primeportal/?q=autocrine_model
Autocrine Signaling | Protocol (Translated to Chinese)Autocrine Signaling | Protocol (Translated to Chinese)
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
https://www.jove.com/science-education/10973/?language=Chinese
Autocrine Signaling | Protocol (Translated to Chinese)Autocrine Signaling | Protocol (Translated to Chinese)
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
https://www.jove.com/science-education/12002/autocrine-signaling?language=Chinese
Activation via the CD3 and CD16 pathway mediates interleukin-2-dependent autocrine proliferation of granular lymphocytes in...Activation via the CD3 and CD16 pathway mediates interleukin-2-dependent autocrine proliferation of granular lymphocytes in...
Activation via the CD3 and CD16 pathway mediates interleukin-2-dependent autocrine proliferation of granular lymphocytes in patients with granular lymphocyte proliferative disorders. is an eagle-i resource of type Journal article at Oregon Health & Science University.
http://ohsu.eagle-i.net/i/0000012c-2cd8-d302-733c-567c80000000
Mechanism of hippocampal neuron death in the trisomy 16 mouse: Failure of BDNF signalingMechanism of hippocampal neuron death in the trisomy 16 mouse: Failure of BDNF signaling
Down syndrome (DS; trisomy 21) is the most common genetic cause of mental retardation, affecting about one in every 800 individuals. About 60% of the genes on human chromosome 21 are present on mouse chromosome 16 and mouse trisomy 16 (Ts16) has been studied as a potential model for DS. Cultured hippocampal neurons from embryonic Ts16 mice undergo accelerated death by apoptosis in vitro compared with neurons from Euploid littermates. The purpose of this study was to determine the molecular mechanism underlying this accelerated death. Brain-derived Neurotrophic Factor (BDNF), acting through its receptor, trkB, is a well-described autocrine survival factor for hippocampal neurons. BDNF binding to trkB initiates receptor dimerization, autophosphorylation, and activation of several signaling pathways, including AKT and ERK, two signal transduction molecules whose activation by phosphorylation promotes cell survival. To test whether BDNF promoted autocrine survival in Euploid and Ts16 neuronal ...
https://archive.hshsl.umaryland.edu/handle/10713/1202
Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function. - PubMed -...Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function. - PubMed -...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/7679985?dopt=Abstract
E-GEOD-40849 - Vav proteins orchestrate a keratinocyte auto/paracrine program critical for skin tumorigenesis. - OmicsDIE-GEOD-40849 - Vav proteins orchestrate a keratinocyte auto/paracrine program critical for skin tumorigenesis. - OmicsDI
Cutaneous squamous tumors rely on autocrine/paracrine loops for proper fitness. Targeting this Achilles heel is therefore considered a potential avenue for patient treatment. However, the mechanisms that engage and sustain such programs during tumor ontogeny are poorly understood. Here, we show that two Rho/Rac activators, the exchange factors Vav2 and Vav3, control the expression of an epithelial autocrine/paracrine program that regulates keratinocyte survival and proliferation as well as the creation of an inflammatory microenvironment. Vav proteins are also critically involved in some of the subsequent autocrine signaling loops activated in keratinocytes. The genetic inactivation of both Vav proteins reduces tumor multiplicity without hampering skin homeostasis, thus suggesting that pan-specific Vav therapies may be useful in skin tumor prevention and treatment. The dorsal skin of WT and DKO mice (Vav2-/-;Vav3-/-) were treated with either one or four applications of phorbol ester 12-O
https://www.omicsdi.org/dataset/arrayexpress-repository/E-GEOD-40849
Autocrine regulation of asthmatic airway inflammation: role of airway smooth muscle | Respiratory Research | Full TextAutocrine regulation of asthmatic airway inflammation: role of airway smooth muscle | Respiratory Research | Full Text
A large number of cells in the airways, such as eosinophils, mast cells, lymphocytes, neutrophils and ASM cells, contribute to the pathogenesis of inflammatory airway diseases. Here we specifically discuss potential anti-inflammatory interventions that target ASM-driven inflammation.. As mentioned earlier, ASM cells are potential targets for glucocorticosteroid therapy. Other workers and ourselves have recently demonstrated that the expression and secretion of pro-inflammatory cytokines and chemokines by ASM cells in vitro can be inhibited by glucocorticosteroid treatment [11,12,17,25,26,32,36,40]. COX-2 induction and the resulting production of arachidonic acid metabo-lites could similarly be inhibited by treatment with dexa-methasone [13,51]. Suppression of the COX-2 pathway, on the contrary, may result in deleterious consequences considering the bronchoprotective properties of PGE2 in asthmatic airways.. Mechanistically, it has been proposed that glucocorticoid receptors interact with ...
https://respiratory-research.biomedcentral.com/articles/10.1186/rr160
Autocrine Regulation of Myocyte Cx43 Expression by VEGF | Circulation ResearchAutocrine Regulation of Myocyte Cx43 Expression by VEGF | Circulation Research
In this study, we showed that exogenously supplied VEGF and TGF-β rapidly increased Cx43 expression in cultured neonatal rat ventricular myocytes in a manner similar to the effects induced by brief intervals of linear pulsatile stretch. We also showed that specific antibodies against either VEGF or TGF-β blocked stretch-induced upregulation of Cx43 expression. Stretch-conditioned medium contained increased levels of VEGF and was able to stimulate Cx43 expression in cells not subjected to stretch. Anti-VEGF antibody blocked the effects of exogenous TGF-β on Cx43 expression but anti-TGF-β antibody did not block the VEGF effect. Thus, we confirmed original observations by Seko et al3 that pulsatile stretch stimulates secretion of VEGF, mediated at least in part by TGF-β, and we now provide evidence that directly implicates these pathways in stretch-mediated upregulation of Cx43.. It is likely that pulsatile stretch causes secretion of multiple mediators from cardiac myocytes and nonmyocytic ...
http://circres.ahajournals.org/content/90/6/671.full
Gianfranco Alpini, PhDGianfranco Alpini, PhD
My research program focuses on the regulation of cholangiocyte proliferation/damage during cholangiopathies. My studies have demonstrated the key role of a number of factors such as vascular and nerve factors, melatonin, secretin, biogenic amines and sex hormones (expressed and secreted by cholangiocytes) in the regulation of biliary growth/damage by autocrine/paracrine mechanisms. Proliferating cholangiocytes display a neuroendocrine phenotype and secrete and respond to a number of hormones, neuropeptides and neurotransmitters in autocrine and paracrine signaling mechanisms. My research interests also include determining the interactions that occur between cholangiocytes and other cell types (such as hepatocytes, hepatic stellate cells, and vascular endothelial cells) in the biliary microenvironment during both cholestasis and cholangiocarcinogenesis. My program evaluates the various signaling mechanisms regulating the balance between biliary growth/damage. I have expertise in the areas of ...
https://medicine.iu.edu/faculty/43398/alpini-gianfranco
Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology - ImmunologyImmunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology - Immunology
|jats:p|Resident fibroblasts at sites of infection, chronic inflammation, or cancer undergo phenotypic and functional changes to support leukocyte migration and, in some cases, aggregation into tertiary lymphoid structures (TLS). The molecular programming that shapes these changes and the functional requirements of this population in TLS development are unclear. Here, we demonstrate that external triggers at mucosal sites are able to induce the progressive differentiation of a population of podoplanin (pdpn)-positive stromal cells into a network of immunofibroblasts that are able to support the earliest phases of TLS establishment. This program of events, that precedes lymphocyte infiltration in the tissue, is mediated by paracrine and autocrine signals mainly regulated by IL13. This initial fibroblast network is expanded and stabilized, once lymphocytes are recruited, by the local production of the cytokines IL22 and lymphotoxin. Interfering with this regulated program of events or depleting the
https://www.immunology.ox.ac.uk/publications/1023422
Phosphoinositide 3-kinase γ: a key modulator in inflammation and allergy | Biochemical Society TransactionsPhosphoinositide 3-kinase γ: a key modulator in inflammation and allergy | Biochemical Society Transactions
Chronic inflammation and allergy involve the activation of tissue-resident cells and, later on, the invasion of effector cells. We have previously shown that the loss of phosphoinositide 3-kinase (PI3K) γ impairs chemokine-dependent migration of neutrophils and macrophages both in vitro and in vivo. On the other hand, PI3Kγ is not required either during phagocytic processes or in the activation of bactericidal activities like granule secretion and particle-mediated respiratory burst in neutrophils. Tissue mast cells are key regulators in allergy and inflammation and release histamine upon clustering of their IgE receptors. We have demonstrated that murine mast cell responses are exacerbated in vitro and in vivo by autocrine signals, and require functional PI3Kγ. Adenosine, acting through the A3 adenosine receptor, as well as other agonists of Gαi-coupled receptors, transiently increased PtdIns(3,4,5)P3 exclusively via PI3Kγ. PI3Kγ-derived PtdIns(3,4,5)P3 was instrumental for initiation of ...
http://www.biochemsoctrans.org/content/31/1/275
Autocrine-paracrine inhibition of growth hormone and prolactin production by GH|sub|3|/sub| cell-conditioned medium -...Autocrine-paracrine inhibition of growth hormone and prolactin production by GH|sub|3|/sub| cell-conditioned medium -...
Fingerprint Dive into the research topics of Autocrine-paracrine inhibition of growth hormone and prolactin production by GH,sub,3,/sub, cell-conditioned medium. Together they form a unique fingerprint. ...
https://augusta.pure.elsevier.com/en/publications/autocrine-paracrine-inhibition-of-growth-hormone-and-prolactin-pr/fingerprints/?sortBy=alphabetically
Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human...Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human...
Amphiregulin (AR) is a newly discovered glycosylated, 84-amino acid residue polypeptide growth regulator which has sequence homology to the EGF family of proteins. To obtain immunological reagents to study the biological role of AR, two synthetic peptides containing sequences corresponding to distinct regions of AR were used to generate polyclonal antibodies in rabbits. One preparation of antipeptide antibodies directed against residues 26-44 of AR (AR-Ab2) was most effective in the detection of native AR, whereas another preparation of antibodies against residues 8-26 (AR-Ab1) was found to be most efficacious in the detection of AR in formalin-fixed and paraffin-embedded tissues. The growth of a colon carcinoma cell line, Geo, which proliferates autonomously under serum-free conditions, was stimulated by the exogenous addition of AR or EGF. Half-maximal stimulation of this growth was observed at 40 and 200 pM of EGF and AR, respectively. A mAb to the extracellular domain of the EGF receptor ...
http://jcb.rupress.org/content/118/3/741
Terry Evans | Melatonin membrane receptors in peripheral tissuesTerry Evans | Melatonin membrane receptors in peripheral tissues
This allows a competent direct communication between -cells as well as the intra-islet capillaries, ensuring an instant response to increases in blood sugar levels by secreting insulin [180,181]. advancement of T2DM. IGF-1 and Insulin signaling pathways play critical tasks in maintaining the differentiated phenotype of -cells. The autocrine actions of secreted insulin on -cells is controversial still; function by us while others offers shown positive and negative activities by insulin on -cells. We discuss results that support the idea of an autocrine actions of secreted insulin on -cells. The hypothesis of whether, through the advancement of T2DM, secreted insulin primarily functions as a good friend and plays a part in -cell payment and, at a stage later, turns into a foe and plays a part in -cell decompensation will be discussed. gene in mice led to lack of -cell phenotype due to impaired manifestation of insulin as well as the blood sugar transporter, Glut2; these mice created T2DM with age ...
https://cancer-basics.com/author/wpadmin/
Autocrine signalling - WikipediaAutocrine signalling - Wikipedia
Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell. This can be contrasted with paracrine signaling, intracrine signaling, or classical endocrine signaling. An example of an autocrine agent is the cytokine interleukin-1 in monocytes. When interleukin-1 is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it.[citation needed] Another example occurs in activated T cell lymphocytes, i.e., when a T cell is induced to mature by binding to a peptide:MHC complex on a professional antigen-presenting cell and by the B7:CD28 costimulatory signal. Upon activation, low-affinity IL-2 receptors are replaced by high-affinity IL-2 receptors consisting of α, β, and γ chains. The cell then releases IL-2, which binds to its own new IL-2 receptors, causing self-stimulation and ...
https://en.wikipedia.org/wiki/Autocrine_signalling
Purified anti-human/mouse IL-21 Antibody anti-IL-21 - 7H20-I19-M3Purified anti-human/mouse IL-21 Antibody anti-IL-21 - 7H20-I19-M3
Purified anti-human/mouse IL-21 Antibody - Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses.  These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells.  It can also be proapoptotic for B cells and NK cells.  Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases..
https://www.biolegend.com/fr-fr/products/purified-anti-human-mouse-il-21-antibody-5154
Purified anti-human/mouse IL-21 Antibody anti-IL-21 - 7H20-I19-M3Purified anti-human/mouse IL-21 Antibody anti-IL-21 - 7H20-I19-M3
Purified anti-human/mouse IL-21 Antibody - Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses.  These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells.  It can also be proapoptotic for B cells and NK cells.  Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases..
https://www.biolegend.com/en-gb/products/purified-anti-human-mouse-il-21-antibody-5154
Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries
Lytic CD8+ T cells at the psoriasis plaques epidermis secrete IL‐17, IL‐21 and IL‐22 and depends on autocrine TNFalpha production. IL‐17‐producing CD4+ T ...
https://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:secretion
The Antiviral Response to Gamma Interferon | Journal of VirologyThe Antiviral Response to Gamma Interferon | Journal of Virology
Takaoka et al. have presented persuasive evidence that in MEFs the IFN-γ response is substantially augmented through autocrine IFN-α/β and that cross-recruitment and phosphorylation of the IFNAR1 subunit of the IFN-α/β receptor occurs in response to IFN-γ in these cells (24). We have been unable to obtain evidence for or against recruitment or phosphorylation of IFNAR1 in response to IFN-γ in the HT1080-based human cell systems used here (H. Isharc and I. M. Kerr, unpublished data). In a potentially analogous but inverse situation, cross-phosphorylation of the IFNGR1 subunit of the IFN-γ receptor in response to activation of erythropoietin/gp130 receptor chimeras in HT1080-based cell lines is observed. Importantly, however, such receptor cross-phosphorylation plays no part in the IFN-γ-like response observed (23), a result which emphasizes that even if IFNAR1 were recruited and phosphorylated in response to IFN-γ, proof of necessity of this for the IFN-γ antiviral response would ...
https://jvi.asm.org/content/76/18/9060
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Despite the considerable improvements in our knowledge of AML biology in recent years, the treatment of this disease remains a challenge for clinicians. Major efforts have been made to develop new compounds that target the preferentially activated signaling pathways implicated in AML cell proliferation and survival. The PI3K/Akt/mTOR axis represents a promising therapeutic target in several cancers, as many components of these signaling pathways are frequently deregulated in tumor cells. We recently showed that a constitutive activation of PI3K is detected in ∼50% of primary AML samples at diagnosis(8), mostly due to an autocrine stimulation of the IGF-1 receptor (9). Accordingly, either the blockade of this IGF-1 autocrine production or the specific inhibition of PI3K p110δ activity leads to a strong decrease of AML cell proliferation (4, 5, 9). The constitutive activation of the mTORC1 pathway is detectable in virtually almost all AML patient samples, which emphasized the potential of using ...
http://clincancerres.aacrjournals.org/content/16/22/5424
Olympus® GIF-XP230 Gastroscope - IEC - Innovative Endoscopy Company, Inc.Olympus® GIF-XP230 Gastroscope - IEC - Innovative Endoscopy Company, Inc.
IEC has offered premium surgical equipment, endoscope repair/replacement parts, and services to the international healthcare community for over 15 years.
http://www.endoscopy.md/Items/Search?cwitmid=5522&ctid=0&newitm=True
FGF Induces Hypertrophy and Angiogenesis in Hibernating Myocardium | Circulation ResearchFGF Induces Hypertrophy and Angiogenesis in Hibernating Myocardium | Circulation Research
For several years there has been considerable interest in stimulating angiogenesis by a variety of growth factors, including the family of fibroblast growth factors (FGF). FGF-5 is a protooncogene known to stimulate cell growth and proliferation in multiple cell types, including cancer.1 The cardiac myocyte can also produce different isoforms of FGFs, eg, it has been shown that the expression of basic FGF increases in hibernating myocardium,2 which was the disease state of interest in the current study published in Circulation Research.3 The most commonly cited effect of FGF-5 in the heart is to promote angiogenesis. Several studies have shown that gene transfer of FGF-5 in the heart increases vessel formation and regional blood flow.4-6 This effect is mediated by a production of FGF-5 by the cardiac myocytes, followed by its release in the extracellular space. In addition, FGF-5 can function as an autocrine/paracrine mechanism of cardiac cell growth and as a cytoprotective mechanism against ...
http://circres.ahajournals.org/content/96/7/705
Lipoxygenase - WikipediaLipoxygenase - Wikipedia
Lipoxygenases (EC 1.13.11.-) are a family of (non-heme), iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells. The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives. Lipoxygenases are found in eukaryotes (plants, fungi, animals, protists); while the third domain of terrestrial life, the archaea, ...
https://en.wikipedia.org/wiki/Lipoxygenase
Endotoxins modulate the autocrine function of organ cultured donor corneas and increase the incidence of endothelial cell death...Endotoxins modulate the autocrine function of organ cultured donor corneas and increase the incidence of endothelial cell death...
Phlogistic reactions, whether of extraocular or intraocular origin, tend to be down regulated by the avascular, and hence immune privileged, cornea. And this feature is recognised as being essential for a favourable graft prognosis. In situ, corneal tissue is protected from potential inflammatory stimulants, such as endotoxins, by the epithelial and vascular barriers; but in vitro, the situation is different. Under these conditions, contamination of culture media with endotoxins could have untoward effects; these may be manifested either directly, by overt changes in cell morphology, and/or by a more discreet influence on the tissues immunological status, the consequences of which may be realised only after transplantation, by a compromised graft performance.. In the current study, we monitored the media of organ cultured corneas for a number of cytokine mediators of the inflammatory response, both before and after spiking with endotoxin; these data were then compared with those pertaining to ...
http://bjo.bmj.com/content/81/12/1093
Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell...Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell...
article{99c2b32e-f9cf-4afb-8052-6d71d776ad00, abstract = {The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.}, author = {Sitnicka Quinn, Ewa and Bryder, David and Theilgaard-Mönch, Kim and Buza-Vidas, Natalija and Adolfsson, Jörgen and Jacobsen, Sten Eirik W}, issn = ...
https://lup.lub.lu.se/search/publication/110578
Autocrine Activation of Neuronal NMDA Receptors by Aspartate Mediates Dopamine- and cAMP-Induced CREB-Dependent Gene...Autocrine Activation of Neuronal NMDA Receptors by Aspartate Mediates Dopamine- and cAMP-Induced CREB-Dependent Gene...
Our hypothesis is based on several lines of evidence. First, the effects of cAMP and DA on both 4xCRE (Figs. 3a,b, 5) and c-fos and BDNF mRNA expression (Fig. 6) are blocked by NMDAR antagonists. Second, two structurally distinct inhibitors of neuronal EAA uptake, TBOA (Fig. 7) and trans-PDC (supplemental Fig. S3, available at www.jneurosci.org as supplemental material), potentiated the stimulation of gene transcription by cAMP. Third, the aspartate+glutamate-, but not the glutamate-only-, scavenging system abolished stimulation of CREB-dependent gene transcription by forskolin (Fig. 8); the aspartate-scavenging enzyme, GOT, degrades l- but not d-aspartate demonstrating that l-aspartate is the active extracellular EAA in this signaling pathway. Finally, forskolin was found to induce release of aspartate but not glutamate (Fig. 9). Together, these results lead to the conclusion that cAMP-induced release of aspartate and the resulting activation of NR2B-containing NMDARs mediate the effects of ...
http://www.jneurosci.org/content/29/40/12702.long
Autocrine | definition of autocrine by Medical dictionaryAutocrine | definition of autocrine by Medical dictionary
Looking for online definition of autocrine in the Medical Dictionary? autocrine explanation free. What is autocrine? Meaning of autocrine medical term. What does autocrine mean?
https://medical-dictionary.thefreedictionary.com/autocrine
Association between Interleukin-18 Polymorphisms and Hepatocellular Carcinoma Occurrence and Clinical ProgressionAssociation between Interleukin-18 Polymorphisms and Hepatocellular Carcinoma Occurrence and Clinical Progression
1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90 2. Bosetti C, Turati F, La Vecchia C. Hepatocellular carcinoma epidemiology. Best Pract Res Clin Gastroenterol. 2014;28:753-770 3. Li S, Sun R, Chen Y, Wei H, Tian Z. TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression. Cancer Res. 2015;75:986-995 4. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007;317:121-124 5. He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013;155:384-396 6. Gu FM, Li QL, Gao Q, Jiang JH, Zhu K, Huang XY, Pan JF, Yan J, ...
http://www.medsci.org/v13p0556.htm
Centrum Wiskunde & Informatica: Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in the...Centrum Wiskunde & Informatica: Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in the...
Epithelial branching morphogenesis drives the development of organs such as the lung, salivary gland, kidney and the mammary gland. It involves cell proliferation, cell differentiation and cell migration. An elaborate network of chemical and mechanical signals between the epithelium and the surrounding mesenchymal tissues regulates the formation and growth of branching organs. Surprisingly, when cultured in isolation from mesenchymal tissues, many epithelial tissues retain the ability to exhibit branching morphogenesis even in the absence of proliferation. In this work, we propose a simple, experimentally plausible mechanism that can drive branching morphogenesis in the absence of proliferation and cross-talk with the surrounding mesenchymal tissue. The assumptions of our mathematical model derive from in vitro observations of the behaviour of mammary epithelial cells. These data show that autocrine secretion of the growth factor TGFβ1 inhibits the formation of cell protrusions, leading to ...
https://ir.cwi.nl/pub/29792/
Autocrine signaling - WikipediaAutocrine signaling - Wikipedia
The growing knowledge behind the mechanism of autocrine signaling in cancer progression has revealed new approaches for therapeutic treatment. For example, autocrine Wnt signaling could provide a novel target for therapeutic intervention by means of Wnt antagonists or other molecules that interfere with ligand-receptor interactions of the Wnt pathway.[2][3] In addition, VEGF-A production and VEGFR-2 activation on the surface of breast cancer cells indicates the presence of a distinct autocrine signaling loop that enables breast cancer cells to promote their own growth and survival by phosphorylation and activation of VEGFR-2. This autocrine loop is another example of an attractive therapeutic target.[8]. In HER2 overexpressing breast cancers, the HER2-IL-6-STAT3 signaling relationship could be targeted to develop new therapeutic strategies.[6] HER2 kinase inhibitors, such as lapatinib, have also demonstrated clinical efficacy in HER2 overexpressing breast cancers by disrupting a neuregulin-1 ...
https://en.m.wikipedia.org/wiki/Autocrine
Nitric oxide-generating system as an autocrine mechanism in hu...Nitric oxide-generating system as an autocrine mechanism in hu...
Nitric oxide-generating system as an autocrine mechanism in human polymorphonuclear leucocytes.: Recent data [Lopéz-Farré, Riesco, Moliz, Egido, Casado, Hernand
https://www.mysciencework.com/publication/show/nitric-oxide-generating-system-as-an-autocrine-mechanism-in-human-polymorphonuclear-leucocytes
Programmed cell death has a vital role in embryonic development and - BRAF inhibitors on Immune-based antitumor therapyProgrammed cell death has a vital role in embryonic development and - BRAF inhibitors on Immune-based antitumor therapy
Programmed cell death has a vital role in embryonic development and tissue homeostasis. oxygen varieties (ROS) in tuberculosis illness. Experimental studies have also demonstrated that upregulation of RIPK3 and MLKL detected in alcoholic and drug-induced liver injury suggests that necroptosis is also involved in sterile inflammation. Application of Necrostatin (Nec)-1 or depletion of RIPK3 protects liver cells from these types of injuries [74]. Parasitic diseases like leishmaniasis and malaria generally caused hemolysis, Lenalidomide supplier anemia, and sometimes bleeding. These result due to rupturing of red blood corpuscles (RBCs) leading to release of hemoglobin (Hb) into circulation; heme is produced on oxidation of Hb leading to initiation of the Fenton reaction and culminates with generation of ROS. Heme is also responsible for direct activation of TLR4, leading to autocrine secretion of ROS and TNF, and they activate the RIPK1/3-dependent necroptosis in a synergistic manner [75]. In ...
http://www.bioinbrief.com/2019/06/12/programmed-cell-death-has-a-vital-role-in-embryonic-development-and/
CMS-MITACS Joint Conference 2007CMS-MITACS Joint Conference 2007
Gonadotropin-releasing hormone (GnRH) is a decapeptide hormone secreted by GnRH neurons located in the hypothalamus. It is responsible for the onset of puberty and the regulation of hormone release from the pituitary. There is a strong evidence suggesting that these GnRH neurons are intrinsically capable of generating pulsatile and episodic neurosecretion of this hormone. However, the underlying mechanism for the GnRH-pulse generator remains obscure. The discovery of GnRH receptors allowing GnRH to exert autocrine regulation on its own release, led several experimentalist in NIH to propose in 2003 a mechanism underlying this effect. We developed in 2006 a mathematical model describing the proposed mechanism, then we extended it to explain synchrony observed in GnRH neurons by incorporating the idea of a common pool of GnRH hormone. In this talk, we shall present this model and analyze several aspects of it, especially robustness. We shall show that the coupling of a heterogeneous family of GnRH ...
https://cms.math.ca/Events/summer07/abs/mb.html?nomenu=1
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2390 Janus kinase 2 (JAK2) is a cytokine receptor associated tyrosine kinase. Binding of cytokines to their specific receptors leads to their dimerization and activation of associated JAKs. Activated JAKs phosphorylate specific tyrosine residues in the cytoplasmic chains of the receptor, which now act as docking sites for SH2 containing latent transcription factors known as STATs. Once bound to the receptor, STATs are activated by JAKs through phosphorylation of their tyrosine residues. Activated STATs form stable dimers and translocate to the nucleus, where they bind specific promoter sequences of their target genes involved in cell proliferation and survival, such as Bcl-xL, Bcl-2, c-myc and cyclin D1. Tumor cell lines and samples derived from hematopoetic malignancies (leukemia, lymphoma and multiple myeloma) and solid tumors (breast, head and neck, lung, prostrate and ovarian cancers) exhibit deregulated JAK-STAT signaling, which can be attributed to autocrine cytokine production or growth ...
http://cancerres.aacrjournals.org/content/67/9_Supplement/2390
CytokinesCytokines
NovoPro offers a wide selection of tools for research on cytokines and their receptors. These include high-purity recombinant proteins, high-specific antibodies and ORF cDNA clones.. Cytokines are a large group of proteins, peptides or glycoproteins that are secreted by specific cells of immune system. Cytokines are a category of signaling molecules that mediate and regulate immunity, inflammation and hematopoiesis. Cytokines are produced throughout the body by cells of diverse embryological origin. Cytokine is a general name; other names are defined based on their presumed function, cell of secretion, or target of action. For example, cytokines made by lymphocytes can also be referred to as lymphokines, while interleukins are made by one leukocyte and act on other leukocytes. And chemokines are cytokines with chemotactic activities.. Cytokines may act on the cells that secrete them (autocrine action), on nearby cells (paracrine action), or in some instances on distant cells (endocrine ...
https://www.novoprolabs.com/cytokines/
autocrine hypothesisautocrine hypothesis
Autocrine hypothesis definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
http://www.dictionary.com/browse/autocrine-hypothesis
VEGF-A promoted DJM-1 cell proliferation via NRP1 in an | Open-iVEGF-A promoted DJM-1 cell proliferation via NRP1 in an | Open-i
VEGF-A promoted DJM-1 cell proliferation via NRP1 in an autocrine manner. (A) A western blot shows that DJM-1 cells expressed NRP1, but not NRP2. DJM-1 cells we
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4582117_biolopen-4-010918-g3&req=4
Cell biologyCell biology
Communication can occur through direct cell contact or endocrine, paracrine, and autocrine signaling. Direct cell-cell contact ... Autocrine is a cell sending a signal to itself by secreting a molecule that binds to a receptor on its surface. Forms of ... Cell communication is important for cell regulation and for cells to process information from the environment and respond ... cell communication, cell cycle, biochemistry, and cell composition. The study of cells is performed using several techniques ...
https://en.wikipedia.org/wiki/Cell_biology
Stuart C. SealfonStuart C. Sealfon
PMID 19356622.CS1 maint: multiple names: authors list (link) Sugar I.P., Sealfon S.C. (2009). "Model of autocrine/paracrine ... signaling in epithelial layer: geometrical regulation of intercellular communication". J Phys Chem B. 113 (31): 10946-56. doi: ...
https://en.wikipedia.org/wiki/Stuart_C._Sealfon
Wnt signaling pathwayWnt signaling pathway
... s use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are ... In Wnt signaling, these proteins act as ligands to activate the different Wnt pathways via paracrine and autocrine routes. ... Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.Int. J. Cancer ... January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5 ...
https://en.wikipedia.org/wiki/Wnt_signaling_pathway
GranulinGranulin
Zhou J, Gao G, Crabb JW, Serrero G (May 1993). "Purification of an autocrine growth factor homologous with mouse epithelin ... Nature Communications. 8: 15277. Bibcode:2017NatCo...815277Z. doi:10.1038/ncomms15277. PMC 5477518. PMID 28541286. Nguyen AD, ... Progranulin may function as an autocrine growth factor in tumorigenesis. The discovery of a GRN mutation leading to lysosomal ... Serrero G (August 2003). "Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in ...
https://en.wikipedia.org/wiki/Granulin
Purinergic signallingPurinergic signalling
Autocrine purinergic signalling is an important checkpoint in the activation of white blood cells. These mechanisms either ... It has an excitatory effect on neurones, and acts as a mediator in neuronal-glial communications. Both adenosine and ATP induce ... The release of ATP and an autocrine feedback through P2RY2 and A3 receptors are signal amplifiers. Hypoxia-inducible factors ... Corriden, R.; Insel, P. A. (5 January 2010). "Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation". ...
https://en.wikipedia.org/wiki/Purinergic_signalling
Paracrine signalingParacrine signaling
... is form of cell signaling, a type of cellular communication in which a cell produces a signal to induce ... and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. ...
https://en.wikipedia.org/wiki/Paracrine_signaling
Macrophage polarizationMacrophage polarization
Sica A, Saccani A, Bottazzi B, Polentarutti N, Vecchi A, van Damme J, Mantovani A (January 2000). "Autocrine production of IL- ... Nature Communications. 8: 14293. Bibcode:2017NatCo...814293C. doi:10.1038/ncomms14293. PMC 5309815. PMID 28176769. Zeisberger ...
https://en.wikipedia.org/wiki/Macrophage_polarization
ConnexinConnexin
Recent studies have shown the existence of communication between adherens junctions and gap junctions, suggesting a higher ... connexin hemichannels and pannexin channels can contribute to autocrine/paracrine signaling pathways, and (3) different ... "Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by ... "Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with ...
https://en.wikipedia.org/wiki/Connexin
EndocrinologyEndocrinology
This definition holds for most "classical" hormones, but there are also paracrine mechanisms (chemical communication between ... cells within a tissue or organ), autocrine signals (a chemical that acts on the same cell), and intracrine signals (a chemical ...
https://en.wikipedia.org/wiki/Endocrinology
Folliculostellate cellFolliculostellate cell
"Cell-to-cell communication in the anterior pituitary: evidence for gap junction-mediated exchanges between endocrine cells and ... autocrine/paracrine control of anterior pituitary cell function though the use of cytokines and growth factors, intrapituitary ... as the IL-6 is a mediator in communication between the endocrine and immune system. IL-6 production by FS cells induces hormone ... A route for long-distance communication in the anterior pituitary". Proceedings of the National Academy of Sciences. 98 (15): ...
https://en.wikipedia.org/wiki/Folliculostellate_cell
OogenesisOogenesis
Endocrine, paracrine, and autocrine signaling pathways that regulate ovulation. Trends Endocrinol. Metab. 29:313-325. NCBI - ... Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle. Ann. Rev. Physiol. 79:237- ... Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle. Ann. Rev. Physiol. 79:237- ...
https://en.wikipedia.org/wiki/Oogenesis
Autocrine signalingAutocrine signaling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine ... Autocrine+signaling at the US National Library of Medicine Medical Subject Headings (MeSH) "Autocrine versus juxtacrine ... and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR ...
https://en.wikipedia.org/wiki/Autocrine_signaling
Sardul Singh GurayaSardul Singh Guraya
... and Autocrine Regulation of Structure and Functions, Cellular And Molecular Biology For Human, (all on Cell and Molecular ... and Intercellular Communication. Science Publishers. ISBN 978-1-57808-066-3. "Guraya SS[au] on Pubmed". Pubmed. 2016. Retrieved ... and Autocrine Regulation of Structure and Functions. Science Publishers. ISBN 978-1-57808-165-3. Sardul S. Guraya (1 January ... and Autocrine Regulation of Structure and Functions. Science Publishers. ISBN 978-1-57808-165-3. Sardul S. Guraya (1 January ...
https://en.wikipedia.org/wiki/Sardul_Singh_Guraya
ProlactinProlactin
The hormone acts in endocrine, autocrine and paracrine manner through the prolactin receptor and numerous cytokine receptors. ... Nature Communications. 5: 5861. Bibcode:2014NatCo...5.5861L. doi:10.1038/ncomms6861. PMC 4284646. PMID 25519203. Porto-Neto LR ... an autocrine growth factor for lymphoproliferation". Proceedings of the National Academy of Sciences of the United States of ... where they regulate hair growth and moulting in an autocrine fashion. Elevated levels of prolactin can inhibit hair growth, and ...
https://en.wikipedia.org/wiki/Prolactin
Annexin A2Annexin A2
This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. Epigenetic regulation ... Biochemical and Biophysical Research Communications. 198 (3): 983-9. doi:10.1006/bbrc.1994.1140. PMID 8117306. Maruyama K, ... "Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone ... "Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone ...
https://en.wikipedia.org/wiki/Annexin_A2
Eboluzio, entziklopedia askea.Eboluzio, entziklopedia askea.
Takagi, Y.; Fukase, M.; Takata, S.; Yoshimi, H.; Tokunaga, O.; Fujita, T. (1990-04-30) «Autocrine effect of endothelin on DNA ... synthesis in human vascular endothelial cells» Biochemical and Biophysical Research Communications (2): 537-543 ISSN 0006-291X ...
https://eu.wikipedia.org/wiki/Eboluzioa
Endocrine systemEndocrine system
Autocrine[edit]. Main article: Autocrine signalling. Autocrine signaling is a form of signaling in which a cell secretes a ... Juxtacrine signaling is a type of intercellular communication that is transmitted via oligosaccharide, lipid, or protein ... Endocrine, paracrine, and autocrine signaling have all been implicated in proliferation, one of the required steps of ... The term hormone is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or ...
https://en.wikipedia.org/wiki/Human_Endocrine_System
C-C chemokine receptor type 7C-C chemokine receptor type 7
"Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling" ( ... Biochemical and Biophysical Research Communications. 215 (2): 737-43. doi:10.1006/bbrc.1995.2525. PMID 7488016. Schweickart VL ...
https://en.wikipedia.org/wiki/C-C_chemokine_receptor_type_7
LYVE1LYVE1
... and role in autocrine cell growth of cell surface retention sequence binding protein-1". The Journal of Biological Chemistry. ... Biochemical and Biophysical Research Communications. 288 (4): 1043-6. doi:10.1006/bbrc.2001.5869. PMID 11689016. Mouta Carreira ...
https://en.wikipedia.org/wiki/LYVE1
Juxtacrine signallingJuxtacrine signalling
2002). "General Principles of Cell Communication". In NCBI bookshelf (ed.). Molecular biology of the cell (4th ed.). New York: ... Other types of cell signaling include paracrine signalling and autocrine signalling. The term "juxtacrine" was originally ... "Autocrine versus juxtacrine signaling modes" - illustration at sysbio.org. ... cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. This signaling can influence the cell ...
https://en.wikipedia.org/wiki/Juxtacrine_signalling
Lymphatic endotheliumLymphatic endothelium
2003). "Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding ... Biochemical and Biophysical Research Communications. 288 (4): 1043-1046. doi:10.1006/bbrc.2001.5869. PMID 11689016. Mouta ...
https://en.wikipedia.org/wiki/Lymphatic_endothelium
Microfluidic cell cultureMicrofluidic cell culture
Recently, co-culture has become the predominant approach to study the effect of cellular communication by culturing two ... autocrine signaling, and juxtacrine signaling. For example, in paracrine signaling, growth factors secreted from one cell ... Bogdanowicz DR, Lu HH (April 2013). "Studying cell-cell communication in co-culture". Biotechnology Journal. 8 (4): 395-6. doi: ... cells can engage in enhanced communication with neighboring cells and cell-extracellular matrix interactions can be modeled. In ...
https://en.wikipedia.org/wiki/Microfluidic_cell_culture
NeovascularizationNeovascularization
These growth factors often act in a paracrine or autocrine fashion; they include fibroblast growth factor, placental growth ... requiring precise coordination of multiple steps and the participation and communication of multiple cell types. The complex ...
https://en.wikipedia.org/wiki/Neovascularization
AdipogenesisAdipogenesis
Choy L, Skillington J, Derynck R (May 2000). "Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte ... Nature Communications. 10 (1): 2757. doi:10.1038/s41467-019-10688-x. PMC 6588633. PMID 31227697.. ...
https://en.wikipedia.org/wiki/Adipogenesis
Implantation (human embryo)Implantation (human embryo)
This communication is conveyed by receptor-ligand-interactions, both integrin-matrix and proteoglycan ones. Another ligand- ... It secretes several autocrine factors, targeting itself and stimulating it to further invade the endometrium. Furthermore, ... Human chorionic gonadotropin is an autocrine growth factor for the blastocyst. Insulin-like growth factor 2, on the other hand ... There is massive communication between the blastocyst and the endometrium at this stage. The blastocyst signals to the ...
https://en.wikipedia.org/wiki/Implantation_(human_embryo)
ABCB5ABCB5
Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.Int. J. Cancer ... Biochemical and Biophysical Research Communications. 402 (4): 711-7. doi:10.1016/j.bbrc.2010.10.091. PMC 2998991. PMID 20977885 ... January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5 ...
https://en.wikipedia.org/wiki/ABCB5
Antineoplastic resistanceAntineoplastic resistance
2001-12-15). "Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells". Cancer Research. 61 ( ... Biochemical and Biophysical Research Communications. 320 (2): 493-500. doi:10.1016/j.bbrc.2004.06.003. PMID 15219856. Miyashita ...
https://en.wikipedia.org/wiki/Antineoplastic_resistance
Succinic acidSuccinic acid
As such, succinate links TCA cycle dysfunction or metabolic changes to cell-cell communication and to oxidative stress-related ... Autocrine succinate signaling promotes retinal neovascularization, triggering the activation of angiogenic factors such as ... Cell Communication and Signaling. 14: 3. doi:10.1186/s12964-016-0126-1. PMC 4709936. PMID 26759054. Bardella, Chiara; Pollard, ...
https://en.wikipedia.org/wiki/Succinic_acid
Brain-derived neurotrophic factorBrain-derived neurotrophic factor
"A BDNF autocrine loop in adult sensory neurons prevents cell death". Nature. 374 (6521): 450-53. Bibcode:1995Natur.374..450A. ... and cognitive stimulation all translates into more neuronal activity and synaptic communication, which can produce structural ...
https://en.wikipedia.org/wiki/BDNF
Autocrine signallingAutocrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine ... Autocrine signaling at the US National Library of Medicine Medical Subject Headings (MeSH) "Autocrine versus juxtacrine ... and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR ...
https://en.wikipedia.org/wiki/Autocrine_signalling
CD30CD30
Biochemical and Biophysical Research Communications. 233 (3): 592-600. doi:10.1006/bbrc.1997.6509. PMID 9168896.. ...
https://en.wikipedia.org/wiki/CD30
Pancreatic isletsPancreatic islets
Islets can influence each other through paracrine and autocrine communication, and beta cells are coupled electrically to six ...
https://en.wikipedia.org/wiki/Islets_of_Langerhans
ApoptosisApoptosis
"Nature Communications. 6: 7439. Bibcode:2015NatCo...6.7439A. doi:10.1038/ncomms8439. PMC 4490561. PMID 26074490.. ...
https://en.wikipedia.org/wiki/Apoptosis
EndocrinologyEndocrinology
This definition holds for most "classical" hormones, but there are also paracrine mechanisms (chemical communication between ... cells within a tissue or organ), autocrine signals (a chemical that acts on the same cell), and intracrine signals (a chemical ...
https://en.m.wikipedia.org/wiki/Endocrinologist
Ligand (biochemistry)Ligand (biochemistry)
"Nature Communications. 1 (7): 100. Bibcode:2010NatCo...1E.100W. doi:10.1038/ncomms1093. PMC 3186516. PMID 20981028.. ...
https://en.wikipedia.org/wiki/Ligand_binding
T helper cellT helper cell
The autocrine or paracrine secretion of IL-2 can bind to that same Th cell or neighboring Th's via the IL-2R thus driving ... B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication.[3] A ... which acts upon itself in an autocrine fashion. Activated T cells also produce the alpha sub-unit of the IL-2 receptor (CD25 or ...
https://en.wikipedia.org/wiki/Helper_T_cells
Cathepsin DCathepsin D
Biochemical and Biophysical Research Communications. 179 (1): 190-6. doi:10.1016/0006-291X(91)91353-E. PMID 1883350.. ... Biochemical and Biophysical Research Communications. 154 (2): 765-72. doi:10.1016/0006-291X(88)90206-9. PMID 3261170.. ...
https://en.wikipedia.org/wiki/Cathepsin_D
Vasoactive intestinal peptideVasoactive intestinal peptide
The SCN coordinates daily timekeeping in the body and VIP plays a key role in communication between individual brain cells ... Conconi MT, Spinazzi R, Nussdorfer GG (2006). "Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation ...
https://en.m.wikipedia.org/wiki/Vasoactive_intestinal_peptide
脳由来神経栄養因子脳由来神経栄養因子
"A BDNF autocrine loop in adult sensory neurons prevents cell death". Nature 374 (6521): 450-3. doi:10.1038/374450a0. PMID ... facilitated by direct communication of neurons and vascular cells (94, 134). ... with increasing exercise intensity, brain ...
https://ja.m.wikipedia.org/wiki/BDNF
Guanylate cyclaseGuanylate cyclase
... and can also function as an autocrine signal. Depending on cell type, it can drive adaptive/developmental changes requiring ... "Nature Communications. 6 (8046): 8046. doi:10.1038/ncomms9046. PMC 4569695. PMID 26345128.. ...
https://en.wikipedia.org/wiki/Guanylate_cyclase
Autocrine signalingAutocrine signaling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine ... and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR ... Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors.[ ...
https://en.m.wikipedia.org/wiki/Autocrine
配體 (生物化學) - 维基百科，自由的百科全配體 (生物化學) - 维基百科，自由的百科全
Nature Communications. 2010, 1 (7): 100. Bibcode:2010NatCo...1E.100W. PMID 20981028. doi:10.1038/ncomms1093.. 引文格式1维护：显式使用等标签 ( ... 自分泌（英语：Autocrine signaling）/旁分泌. *内
https://zh.wikipedia.org/wiki/配體_
Endocrine systemEndocrine system
AutocrineEdit. Main article: Autocrine signalling. Autocrine signaling is a form of signaling in which a cell secretes a ... Juxtacrine signaling is a type of intercellular communication that is transmitted via oligosaccharide, lipid, or protein ... Endocrine, paracrine, and autocrine signaling have all been implicated in proliferation, one of the required steps of ... The term hormone is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or ...
https://en.m.wikipedia.org/wiki/Ovarian_hormones
ThioredoxinThioredoxin
They have also recently been found to play a role in cell-to-cell communication.[7] ... "The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell ... suggestive of a role in intercellular communication". Proceedings of the National Academy of Sciences of the United States of ... Biochemical and Biophysical Research Communications. 295 (3): 663-7. doi:10.1016/s0006-291x(02)00727-1. PMID 12099690.. ...
https://en.wikipedia.org/wiki/Thioredoxin
Fibroblast growth factorFibroblast growth factor
Biochemical and Biophysical Research Communications. 261 (3): 756-65. doi:10.1006/bbrc.1999.1039. PMID 10441498.. ... LMW FGF2 is primarily cytoplasmic and functions in an autocrine manner, whereas HMW FGF2s are nuclear and exert activities ... Biochemical and Biophysical Research Communications. 274 (2): 337-43. doi:10.1006/bbrc.2000.3142. PMID 10913340.. ...
https://en.m.wikipedia.org/wiki/Fibroblast_growth_factor
Gap junctionGap junction
Junctional membrane structure of hybrids between communication-competent and communication-incompetent cells". J. Membr. Biol. ... Allows for chemical communication between cells, through the transmission of small second messengers, such as inositol ... Ehrlich, HP; Diez, T (2003). "Role for gap junctional intercellular communications in wound repair". Wound Repair Regen. 11 (6 ... With the apparent ability for one protein alone to enable intercellular communication seen in gap junctions[109] the term gap ...
https://en.wikipedia.org/wiki/Gap_junction
skinskin
It is maintained as a stem cell layer through an autocrine signal, TGF-a, and through paracrine signal FGF7 aka keratinocyte ... chemical communication, even anti-bacterial/viral properties for protection against pathogens.[15] ...
https://en.wikipedia.org/wiki/Skin
GhrelinGhrelin
Gastric-brain communication is an essential part of energy homeostasis, and several communication pathways are probable, ... autocrine modulators in health and disease". Clinical and Experimental Pharmacology & Physiology. 37 (1): 125-31. doi:10.1111/j ... Biochemical and Biophysical Research Communications. 374 (1): 60-63. doi:10.1016/j.bbrc.2008.06.114. PMID 18611393.. ... Biochemical and Biophysical Research Communications. 280 (1): 132-38. doi:10.1006/bbrc.2000.4065. PMID 11162489.. ...
https://en.wikipedia.org/wiki/Ghrelin
Chemical synapseChemical synapse
This can result from changes in presynaptic calcium as well as feedback onto presynaptic receptors, i.e. a form of autocrine ... mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: wiring ...
https://en.m.wikipedia.org/wiki/Synaptic_cleft
Gastrointestinal tractGastrointestinal tract
"Nature Communications. 11 (205). doi:10.1038/s41467-019-13882-z. PMC 6954273. PMID 31924764. Retrieved 10 January 2020.. ... are mediated through either intracrine or autocrine mechanisms, indicating that the cells releasing these hormones are ...
https://en.m.wikipedia.org/wiki/Guts
Parathyroid hormone-related proteinParathyroid hormone-related protein
PTHrP acts as an endocrine, autocrine, paracrine, and intracrine hormone. It regulates endochondral bone development by ... Biochemical and Biophysical Research Communications. 282 (2): 629-34. doi:10.1006/bbrc.2001.4607. PMID 11401507.. ...
https://en.wikipedia.org/wiki/Parathyroid_hormone-related_protein
12-Hydroxyeicosatetraenoic acid12-Hydroxyeicosatetraenoic acid
... these arachidonic acid metabolites act locally as Autocrine signalling and/or Paracrine signaling agents to regulate the ... Biochemical and Biophysical Research Communications. 420 (2): 428-33. doi:10.1016/j.bbrc.2012.03.012. PMID 22426480. Lee, J. W ... Biochemical and Biophysical Research Communications. 261 (1): 218-23. doi:10.1006/bbrc.1999.1012. PMID 10405349. Ding, X. Z.; ... Biochemical and Biophysical Research Communications. 296 (4): 942-8. doi:10.1016/s0006-291x(02)02014-4. PMID 12200139. Vonach, ...
https://en.wikipedia.org/wiki/12-Hydroxyeicosatetraenoic_acid
Succinic acidSuccinic acid
"Cell Communication and Signaling. 14: 3. doi:10.1186/s12964-016-0126-1. PMC 4709936. PMID 26759054.. ... Autocrine succinate signaling promotes retinal neovascularization, triggering the activation of angiogenic factors such as ... succinate links TCA cycle dysfunction or metabolic changes to cell-cell communication and to oxidative stress-related responses ...
https://en.m.wikipedia.org/wiki/Succinic_acid
NeuromodulationNeuromodulation
Neuropeptides are small proteins used for communication in the nervous system. Neuropeptides represent the most diverse class ...
https://en.wikipedia.org/wiki/Neuromodulator
NeurotransmitterNeurotransmitter
The presence of such a gap suggested communication via chemical messengers traversing the synaptic cleft, and in 1921 German ... Until the early 20th century, scientists assumed that the majority of synaptic communication in the brain was electrical. ...
https://en.wikipedia.org/wiki/Neuro_transmitter
Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of...Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of...
Biochemical and Biophysical Research Communications 2013 436 3 *. Effects of all-trans-retinoic on human gastric cancer cells ... Autocrine signaling in carcinoma: VEGF and the α6β4 integrin. Arthur M Mercurio, Robin E Bachelder, Richard C Bates, Jun Chung ... Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling ... Potential autocrine function of vascular endothelial growth factor in head and neck cancer via vascular endothelial growth ...
https://www.pnas.org/content/98/19/10857/tab-article-info
Immune cell regulation by autocrine purinergic signallingImmune cell regulation by autocrine purinergic signalling
Depending on the types of purinergic receptors that are involved, autocrine signalling can promote or inhibit cell activation ... Stimulation of almost all mammalian cell types leads to the release of cellular ATP and autocrine feedback through a diverse ... Autocrine Communication / physiology* * Chemotaxis / physiology * Humans * Immune Tolerance / physiology * Immunity, Innate / ... Immune cell regulation by autocrine purinergic signalling Nat Rev Immunol. 2011 Mar;11(3):201-12. doi: 10.1038/nri2938. Epub ...
https://pubmed.ncbi.nlm.nih.gov/21331080/
Autocrine Activation of the MET Receptor Tyrosine Kinase in Acute Myeloid LeukemiaAutocrine Activation of the MET Receptor Tyrosine Kinase in Acute Myeloid Leukemia
Autocrine Communication* / drug effects * Autocrine Communication* / genetics * Cell Line, Tumor * Cell Proliferation / drug ... Autocrine Activation of the MET Receptor Tyrosine Kinase in Acute Myeloid Leukemia Nat Med. 2012 Jul;18(7):1118-22. doi: ... Our results show a widespread dependence of AML cells on autocrine activation of MET, as well as the key role of compensatory ... We found HGF expression leading to autocrine activation of its receptor tyrosine kinase, MET, in nearly half of the AML cell ...
https://pubmed.ncbi.nlm.nih.gov/22683780/?dopt=Abstract
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation | Nature MedicineThe ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation | Nature Medicine
Nature Communications (2020) * Amplification of autocrine motility factor and its receptor in multiple myeloma and other ... The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett. 456, 295-300 (1999 ... Nabi, I.R., Watanabe, H. & Raz, A. Identification of B16-F1 melanoma autocrine motility-like factor receptor. Cancer Res. 50, ... Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J. Biol. Chem. 266, 13442- ...
https://www.nature.com/articles/nm1686?error=cookies_not_supported&code=ace7ed99-957b-4fd1-87d5-53220fd7c018
Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1 | Cell Communication and Signaling | Full...Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1 | Cell Communication and Signaling | Full...
Real-Time Cell Analysis (RTCA) assays were performed to assess whether AMF depends on Autocrine motility factor recepter (AMFR ... Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of ... Cell Communication and Signaling volume 17, Article number: 22 (2019) Cite this article ... Li, Y., Jia, Y., Bian, Y. et al. Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1. Cell ...
https://biosignaling.biomedcentral.com/articles/10.1186/s12964-019-0336-4
The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism | Journal of...The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism | Journal of...
... personal communication). Similarly, an activating Tie-2 mutation causes venous malformations that are composed of dilated ... Moreover, the data identify Ang-2 as a rapid autocrine regulator of vascular stability that acts through an internal autocrine ... However, autocrine Ang-2-mediated endothelial-cell detachment cannot be blocked by soluble Tie-2. Taken together, the data ... Keating, M. T. and Williams, L. T. (1988). Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. ...
http://jcs.biologists.org/content/118/4/771
Medicine and evolution, part 13: The fly in the ointment of personalized cancer therapy | ScienceBlogsMedicine and evolution, part 13: The fly in the ointment of personalized cancer therapy | ScienceBlogs
Its growth goes from endocrine stimulated to juxtocrine, paracrine, autocrine. Ion communication ports between cells close, ... They are now autocrine in their regulation (regulate themselves) having begun when first transformed as endocrine e.g. ... Please make a tax-deductible donation if you value independent science communication, collaboration, participation, and open ... estradiol from the ovary, then juxstacrine (nearby) paracrine (next door) then autocrine. The exoskeleton by which its cells ...
https://scienceblogs.com/insolence/2012/04/09/medicine-and-evolution-part-13
Seminar - Christian S. Hardtke: Autocrine peptide signals, self-organization and zombie cells: molecular switches in phloem...Seminar - Christian S. Hardtke: Autocrine peptide signals, self-organization and zombie cells: molecular switches in phloem...
Autocrine peptide signals, self-organization and zombie cells: molecular... ... Communication officer. Umeå Plant Science Centre. Email: [email protected] Phone: +46 70 285 6657 ... Autocrine peptide signals, self-organization and zombie cells: molecular switches in phloem formation. Host: Ove Nilsson. Place ... Seminar - Christian S. Hardtke: Autocrine peptide signals, self-organization and zombie cells: molecular switches in phloem ...
https://www.upsc.se/about-upsc/calendar/227-upsc-calendar/229-seminar/446-seminar-christian-s-hardtke-autocrine-peptide-signals-self-organization-and-zombie-cells-molecular-switches-in-phloem-formation.html
In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptinIn vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin
Nov 1, 1997 , Magazine: Biochemical and Biophysical Research Communications Frühbeck G., Aguado M., Martínez J.A.. Department ... In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. ... These in vitro studies suggest an autocrine/paracrine action of leptin on white fat cells and envisages the involvement of the ...
https://www.cun.es/en/research/scientific-publications/in-vitro-lipolytic-effect-of-leptin-on-mouse-adipocytes-evidence-for-a-possible-autocrine-paracrine-role-of-leptin
Free Chiropractic Flashcards about Pathology 1 Block 1Free Chiropractic Flashcards about Pathology 1 Block 1
communication between two attached celsl. juxtacrine. communication the cell talks to itself. autocrine. ... communication between distant cells. neuroendocrine. Five stages of cellular migration into an inflamed tissue. 1 margination 2 ... Communication between two adjacent cells. gap junctions. ... communication between distant cells endocrine. communication at ...
https://www.studystack.com/flashcard-1799540
Butyrate induces apoptosis in murine macrophages via caspase-3, but independent of autocrine synthesis of tumor necrosis factor...Butyrate induces apoptosis in murine macrophages via caspase-3, but independent of autocrine synthesis of tumor necrosis factor...
Biochemical and Biophysical Research Communications, 260: 775-780. [ Links ]. 33. Litvak DA, Evers BM, Hwang KO, Hellmich MR, ... Butyrate induces apoptosis in murine macrophages via caspase-3, but independent of autocrine synthesis of tumor necrosis factor ... g and autocrine synthesis of TNF-. a and NO.. The physiologic onset of apoptosis is strictly regulated by ligand receptor ... Biochemical and Biophysical Research Communications, 246: 760-764. [ Links ]. 36. Bauer WR, Hates JJ, White JH & Wolffe AP ( ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200004&lng=pt&nrm=iso&tlng=en
Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production | Nature CommunicationsNeutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production | Nature Communications
Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling. J. Biol. Chem. 289, 26794- ...
https://www.nature.com/articles/s41467-018-05387-y?error=cookies_not_supported&code=a98391f2-2143-4f1a-87de-bf2d11eb7cc3
Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling | eLifeAutocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling | eLife
The stomatal precursor cell uses autocrine peptide-receptor kinase signaling to self-inhibit its differentiation potential in ... Stomatal development: a plants perspective on cell polarity, cell fate transitions and intercellular communication * OS Lau ... B) Autocrine signaling model: Facette and Smith (2012) proposed an alternate, autocrine signaling model based on the ... triggers autocrine inhibition of stomatal fate. During normal stomatal development, this autocrine inhibition prevents extra ...
https://elifesciences.org/articles/24102
Autocrine and Paracrine Regulation of the Ovary | Springer for Research & DevelopmentAutocrine and Paracrine Regulation of the Ovary | Springer for Research & Development
... and autocrine signals. Although many of the factors involved in... ... Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science 2002; 296:2178-80.PubMedCrossRef ... Tesone M., Abramovich D., Irusta G., Parborell F. (2009) Autocrine and Paracrine Regulation of the Ovary. In: Chedrese P. (eds ... Involvement of nerve growth factor in the ovulatory cascade: trkA receptor activation inhibits gap junctional communication ...
https://rd.springer.com/chapter/10.1007/978-0-387-88186-7_21
Richard Allen Guyer, Ph.D., M.D. | Harvard Catalyst Profiles | Harvard CatalystRichard Allen Guyer, Ph.D., M.D. | Harvard Catalyst Profiles | Harvard Catalyst
Autocrine Communication. 1. 2015. 182. 0.140. Why? Mice, Inbred C3H. 1. 2015. 1195. 0.140. Why? ...
https://connects.catalyst.harvard.edu/Profiles/display/person/151467/network/researchareas/details
JCI - CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 productionJCI - CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production
This occurs in the context of T cell-DC communication, during which the DC also delivers costimulatory signals. Immature DCs ... P , 0.01 (t test). (C) Schematic representation of the CD27-driven autocrine pathway for IL-2 production at the tissue site ( ... CD27 mediates effector CD8+ T cell survival via an autocrine IL-2 pathway. Nontransgenic Cd27-/- T cells retrovirally ... CD27 mediates survival at the tissue effector site via an autocrine IL-2 pathway. We next examined whether the IL-2 that is ...
https://www.jci.org/articles/view/40178
Wang Lab: Cheng Wang PhDWang Lab: Cheng Wang PhD
YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression. Oncogene, 2015, 34:6040- ... Narrowly regulated cell-cell communication plays critical role in the follicle cell proliferation, differentiation, ... Delineating the paracrine and autocrine regulation of ovarian function. The basic functional unit of the ovary is the follicle ... These findings bolstered our understanding on the mechanisms underlying the endocrine, paracrine and autocrine regulation of ...
https://www.massgeneral.org/obgyn/vcrb/wang-lab
PřF:C8155 Cell signaling - Course InformationPřF:C8155 Cell signaling - Course Information
Endocrine, neurocrine, paracrine, and autocrine communications). 2. Classification of hormones according to the type of ... analyze the signaling mechanisms engaged in the intracellular and intercellular communication;. - present their extended ...
https://is.muni.cz/predmet/sci/C8155?lang=en
Renin-Angiotensin System and Cell Communication in the Failing Heart | HypertensionRenin-Angiotensin System and Cell Communication in the Failing Heart | Hypertension
Autocrine-paracrine mechanisms of vascular myocytes in systemic hypertension. Am J Cardiol. 1987;60:99I-103I. ... Gap junctional communication in excitable tissues: the heart as a paradigm. Prog Biophys Mol Biol. 1994;61:1-35. ... Effect of intracellular injection of calcium and strontium on cell communication in heart. J Physiol.. 1975;250:231-245. ... For investigation of the role of the RAS on the control of cell communication in the ventricle of CM hamsters, gj was measured ...
http://hyper.ahajournals.org/content/27/6/1267
Modulation of NK Cell Autocrine-Induced Eosinophil Chemotaxis by Interleukin-15 and Vitamin D3: A Possible NK-Eosinophil...Modulation of NK Cell Autocrine-Induced Eosinophil Chemotaxis by Interleukin-15 and Vitamin D3: A Possible NK-Eosinophil...
In the current communication, we demonstrated a novel crosstalk between NK cells and eosinophils via IL-15/IL-8 axis. This may ... These results indicate a novel autocrine activity for NK cells in recruiting eosinophils and highlight a novel role for IL-15 ... Modulation of NK Cell Autocrine-Induced Eosinophil Chemotaxis by Interleukin-15 and Vitamin D3: A Possible NK-Eosinophil ... R. Hoontrakoon, H. C. Chu, J. Gardai et al., "Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine ...
https://www.hindawi.com/journals/mi/2011/373589/
Autocrine Signaling | Protocol (Translated to Chinese)Autocrine Signaling | Protocol (Translated to Chinese)
Autocrine signaling is a form of communication where a cell interacts with itself. It is the signaling and targeted cell, ... 14.2: Autocrine Signaling Secreted signals can act on a variety of target cells. In some cases, the cell that secretes a signal ... Autocrine signaling can also play a role in the development of skin cancer by stimulating the development of new blood vessels ... Autocrine signaling is also a major mechanism of cancer cell proliferation. Cancerous cells secrete a variety of growth signals ...
https://www.jove.com/science-education/12002/autocrine-signaling?language=Chinese
Cell Communication Flashcards by | BrainscapeCell Communication Flashcards by | Brainscape
Autocrine Signaling a cell releases a signal affecting cells that are the same type ...
https://www.brainscape.com/flashcards/cell-communication-4597597/packs/6246413
Sue E. Huether, Kathryn L. McCance - Test Bank for Understanding Pathophysiology (6th Ed)-TestBank ( - Understanding...Sue E. Huether, Kathryn L. McCance - Test Bank for Understanding Pathophysiology (6th Ed)-TestBank ( - Understanding...
d. communication. ANS: B Conductivity, not sensory interpretation, homeostasis, or communication, is one of the eight chief ... This action is an example of which of the following signaling types? a. Paracrine b. Autocrine c. Neurohormonal d. Hormonal ANS ... REF: p. 10 7. Which form of cell communication is used to relate to other cells in direct physical contact? a. Cell junction b ... Gap junctions allow for cellular communication between cells. Neither desmosomes nor tight junctions are associated with ...
https://www.coursehero.com/file/64357199/Sue-E-Huether-Kathryn-L-McCance-Test-Bank-for-Understanding-Pathophysiology-6th-Ed-TestBank-/
Purinergic signalling - WikipediaPurinergic signalling - Wikipedia
Autocrine purinergic signalling is an important checkpoint in the activation of white blood cells. These mechanisms either ... It has an excitatory effect on neurones, and acts as a mediator in neuronal-glial communications. Both adenosine and ATP induce ... The release of ATP and an autocrine feedback through P2RY2 and A3 receptors are signal amplifiers. Hypoxia-inducible factors ... Corriden, R.; Insel, P. A. (5 January 2010). "Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation". ...
https://en.wikipedia.org/wiki/Purinergic_signalling
Frontiers | Cellular and Molecular Networking Within the Ecosystem of Cancer Cell Communication via Tunneling Nanotubes | Cell...Frontiers | Cellular and Molecular Networking Within the Ecosystem of Cancer Cell Communication via Tunneling Nanotubes | Cell...
More notably, the transfer of these varied molecules almost invariably plays a critical role in the communication between ... More notably, the transfer of these varied molecules almost invariably plays a critical role in the communication between ... Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. Identification of key cellular ... Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. Identification of key cellular ...
https://www.frontiersin.org/articles/10.3389/fcell.2018.00095/full
Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and...Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and...
The dimensionless group α must exceed unity to allow for autocrine and juxtacrine signaling to occur. The maximal local ... Schematic representation of communication distances, illustrating the definition of the effective communication distance ζ0.5 ... What is required is a definition of an "effective" communication distance. We can define the effective communication distance ... The effective communication distance ζ0.5 is indicated where the c/Km curve at time τ0.5 drops below unity, which occurs at: 14 ...
https://www.pnas.org/content/94/23/12258?ijkey=27ca2b103d1db92945bc0aec2fac8ecbdc62f837&keytype2=tf_ipsecsha
Chapter 18 part 1.pdf - Chapter 18 The Endocrine System part 1 Activities of the organ systems are coordinated by the nervous...Chapter 18 part 1.pdf - Chapter 18 The Endocrine System part 1 Activities of the organ systems are coordinated by the nervous...
... of intercellular communication direct communication synaptic communication autocrine communication paracrine communication ... Autocrine communication: chemical signals are released by exocytosis and act on the same cell ... 7/16/2018 4 ENDOCRINE COMMUNICATION endocrine communication: chemical signals, called hormones , are released by exocytosis ... 7/16/2018 3 INTERCELLULAR COMMUNICATION direct communication : ions and small molecules diffuse directly from the cytoplasm of ...
https://www.coursehero.com/file/50439764/Chapter-18-part-1pdf/
Team:HKUST/Project/Reference - 2010.igem.orgTeam:HKUST/Project/Reference - 2010.igem.org
2007). Bacterial communications in implant infections: a target for an intelligence war. Int J Artif Organs. 30(9):757-63. ... Balaban, N., & Novick, R.P. (1995). Autocrine regulation of toxin synthesis by Staphylococcus aureus. Proc Natl Acad Sci U S A ... Balaban, N., & Novick, R.P. (1995). Autocrine regulation of toxin synthesis by Staphylococcus aureus. Proc Natl Acad Sci U S A ...
http://2010.igem.org/Team:HKUST/Project/Reference
References Anti-Desmin antibody - Cytoskeleton Marker (ab15200) | AbcamReferences Anti-Desmin antibody - Cytoskeleton Marker (ab15200) | Abcam
Li J et al. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-ß signaling. ... Chen J et al. CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl ... Fan J et al. Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine ... Turner CJ et al. Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion. ...
https://www.abcam.com/desmin-antibody-cytoskeleton-marker-ab15200-references.html
Cell biology - WikipediaCell biology - Wikipedia
Communication can occur through direct cell contact or endocrine, paracrine, and autocrine signaling. Direct cell-cell contact ... Autocrine is a cell sending a signal to itself by secreting a molecule that binds to a receptor on its surface. Forms of ... Cell communication is important for cell regulation and for cells to process information from the environment and respond ... cell communication, cell cycle, biochemistry, and cell composition. The study of cells is performed using several techniques ...
https://en.wikipedia.org/wiki/Cell_biology
Intercellular communicationEndocrineMotility factor receptorRegulationPathwayEndothelial cellsInternal autocrine loop mechanismApoptosisPathwaysReceptorSignalingInhibitionExtracellularReceptorsSignalsActivinVEGFIntracellularCellular communicationCellsSecretionPhysiologicalOvarianProliferationNeuronsHormonesRoleSurvivalCytokinesMonocytesCell Communication
Intercellular communication14
  • Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. (frontiersin.org)
  • As key mediators of intercellular communication within the tumor ecosystem, TNTs are the central topic of this article. (frontiersin.org)
  • One important mode of intercellular communication is the release of soluble cyto- and chemokines. (pnas.org)
  • Adenosine triphosphate (ATP) has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles. (mdpi.com)
  • Extracellular vesicles (EVs), such as exosomes and microvesicles, play an important autocrine/paracrine role in intercellular communication. (ovid.com)
  • In the developed organism, intercellular communication coordinates the activities between multiple cell types and makes organism-wide processes such as immune response, growth, and homeostasis. (healthcanal.com)
  • Despite the importance of this process, studies in intercellular communication between specialized cells in higher organisms such as mammals have generally focused on communication between just a few cell types and have been limited in scope to small numbers of ligand-receptor pairs. (healthcanal.com)
  • Gap junction channels, formed by connexins, allow the direct intercellular communication between adjacent cells. (physiology.org)
  • These stiff, adhesive, trypsin- and RNAse-resistant surface nanofilaments add a new dimension to the current structural knowledge of exosome-mediated intercellular communication. (royalsocietypublishing.org)
  • Exosomes are known to play an important role in intercellular communication by extracellular signalling [ 2 ] and horizontal mRNA/microRNA transfer [ 3 ]. (royalsocietypublishing.org)
  • We discuss how these newly recognized nanofilaments may help in modulating, tethering and transport of exosomes for intercellular communication. (royalsocietypublishing.org)
  • Here, we investigated the involvement of gap junction intercellular communication (GJIC) during anchorage-independent clustering of MCF7 breast adenocarcinoma cells. (biomedcentral.com)
  • Q. Hormones are an example of intercellular communication known as _____________ signaling.a. neuralb. (clutchprep.com)
  • Loss of gap junction intercellular communication is critical for tumor progression because it allows the tumor cells to escape growth control, invade, and metastasize. (aacrjournals.org)
Endocrine7
  • Ovarian follicular development and regression is a continuous and cyclic process that depends on a number of endocrine, paracrine, and autocrine signals. (springer.com)
  • These findings bolstered our understanding on the mechanisms underlying the endocrine, paracrine and autocrine regulation of ovarian physiology. (massgeneral.org)
  • Decide which of the following forms of human communication are analogous to autocrine, paracine, endocrine , and synaptic signaling. (physicsforums.com)
  • Cell communication: types of cellular communication: endocrine, paracrine, autocrine and iuxtacrine. (univr.it)
  • The events of early pregnancy are tightly coordinated by means of endocrine, paracrine, juxtacrine, and autocrine cellular communication pathways. (glowm.com)
  • In particular, the surfaces of exosomes form fascinating interfaces that may mediate their transport between cells, e.g. both as autocrine and paracrine factors in tumour microenvironments, as well as effectors for distant cellular targets, analogous to endocrine signalling. (royalsocietypublishing.org)
  • There are four categories of chemical signaling found in multicellular organisms: paracrine signaling, endocrine signaling, autocrine signaling, and direct signaling across gap junctions. (altwongqq.com)
Motility factor receptor6
  • The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. (nature.com)
  • Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. (nature.com)
  • The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. (nature.com)
  • Although AMFR (autocrine motility factor receptor) is well known as a conventional receptor of AMF, which is a protein secreted by tumor cell stimulating tumor motility. (biomedcentral.com)
  • Auf www.antikoerper-online.de finden Sie aktuell 65 Autocrine Motility Factor Receptor (AMFR) Antikörper von 18 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Huang, Xie, Raz: Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor. (antikoerper-online.de)
Regulation5
  • This Review focuses on the roles of autocrine purinergic signalling in the regulation of both innate and adaptive immune responses and discusses the potential of targeting purinergic receptors for treating immune-mediated disease. (nih.gov)
  • Autocrine regulation of toxin synthesis by Staphylococcus aureus . (igem.org)
  • De-regulation of the autocrine Wnt signaling pathway via mutations in APC and Axin have been linked to activation of various types of human cancer. (wikipedia.org)
  • Genetic alterations that lead to de-regulation of the autocrine Wnt pathway result in transactivation of epidermal growth factor receptor (EGFR) and other pathways, in turn contributing to proliferation of tumor cells. (wikipedia.org)
  • Ohhara Y, Shimada-Niwa Y, Niwa R , Kayashima Y, Hayashi Y, Akagi K, Ueda H, Yamakawa-Kobayashi K, Kobayashi S. Autocrine regulation of ecdysone synthesis by 3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis. (go.jp)
Pathway5
  • Further investigation revealed that mutant EGFR could activate the oncogenic STAT3 pathway via upregulated IL-6 autocrine signaling. (wikipedia.org)
  • There is also evidence that glucose, through the hexosamine pathway, can induces autocrine activation of Wnt signalling pathway by stimulating secretion of Wnt proteins. (isciii.es)
  • We conclude that IL-3 deprivation activates 24p3 transcription, leading to synthesis and secretion of 24p3, which induces apoptosis through an autocrine pathway. (umassmed.edu)
  • A key pathway that allows such communication is gap junction (GJ). (physiology.org)
  • In this tumor, the ET-1/ET A R autocrine pathway promotes mitogenesis, apoptosis protection, invasion, and neoangiogenesis. (aacrjournals.org)
Endothelial cells5
  • Ang-2 is mainly produced by endothelial cells and therefore acts primarily in an autocrine manner. (biologists.org)
  • These interactions include not only cell-to-cell communication among malignant cells, but also interactions between malignant and stromal cells within the extracellular matrix, including vascular endothelial cells and cancer-associated fibroblasts. (frontiersin.org)
  • VEGF, produced by carcinoma cells, acts through paracrine signaling on endothelial cells and through autocrine signaling on carcinoma cells. (wikipedia.org)
  • CFs interact with not only cardiac myocytes (CMs) but also with other cells in the heart, including vascular endothelial cells (ECs), smooth muscle cells (SMCs), and immune cells, via direct or indirect cellular communications. (rochester.edu)
  • Intriguingly, miRNAs can be transferred from cell to cell by exosomes, small vesicles that have been shown to mediate the transfer of proteins and RNAs, thus facilitating the exchange of information among cells this might have important implications in autocrine and paracrine communication between both macrophages and endothelial cells. (yale.edu)
Internal autocrine loop mechanism1
  • Taken together, the data demonstrate for the first time the antagonistic Ang-1/Ang-2 concept in a defined cellular model and identify Ang-2 as a rapidly acting autocrine regulator of the endothelium that acts through an internal autocrine loop mechanism. (biologists.org)
Apoptosis2
  • On the other hand, IL-15 effect on human eosinophil is through inhibition of the spontaneous apoptosis via the autocrine production of GM-CSF and thus may perpetuate allergic inflammation by prolonged eosinophil survival [ 4 ]. (hindawi.com)
  • Genetic alterations, response to growth and inhibitory signals, resistance to apoptosis, myofibroblast origin and behaviour, altered cellular communications, and intracellular signalling pathways are all fundamental pathogenic hallmarks of both IPF and cancer. (ersjournals.com)
Pathways3
  • These in vitro studies suggest an autocrine/paracrine action of leptin on white fat cells and envisages the involvement of the OB protein, not only in centrally mediated pathways, but also in physiological functions which take place peripherally. (cun.es)
  • SVZ progenitor cells express transcripts for the appropriate BMP-specific type I and II receptor subunits and selective BMP ligands, suggesting the presence of paracrine or autocrine developmental signaling pathways (or both). (elsevier.com)
  • ETs and their receptors have been implicated in tumor progression through autocrine and paracrine pathways. (aacrjournals.org)
Receptor7
  • We found HGF expression leading to autocrine activation of its receptor tyrosine kinase, MET, in nearly half of the AML cell lines and clinical samples we studied. (nih.gov)
  • Our results show a widespread dependence of AML cells on autocrine activation of MET, as well as the key role of compensatory upregulation of HGF expression in maintaining leukemogenic signaling by this receptor. (nih.gov)
  • Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. (nature.com)
  • Herein, we showed that autocrine motility factor (AMF) binds G protein-coupled estrogen receptor 1 (GPER-1) and then translocates from the plasma membrane to the cytoplasm. (biomedcentral.com)
  • In particular, our previous study unveiled the role of GPR30 (now call GPER1), the membrane G protein-coupled estrogen receptor, in mediating the estrogen action during ovarian cell-cell communication and follicle development. (massgeneral.org)
  • The group looked at the expression of 1,894 ligand-receptor pairs-based on 642 ligands and 589 receptors-that have been reported in the literature so far, and drew up a large-scale map of cell-to-cell communication between 144 primary human cell types. (healthcanal.com)
  • In this process, cell releases chemicals that bind to the autocrine receptor present in the same cell and hence all the required changes take place. (assignmenthelp.net)
Signaling32
  • Real-Time Cell Analysis (RTCA) assays were performed to assess whether AMF depends on Autocrine motility factor recepter (AMFR) signaling in EC cells. (biomedcentral.com)
  • Autocrine signaling is a form of communication where a cell interacts with itself. (jove.com)
  • this is called Autocrine Signaling. (jove.com)
  • Under normal physiological conditions, autocrine signaling is important for homeostasis. (jove.com)
  • Autocrine signaling is also a major mechanism of cancer cell proliferation. (jove.com)
  • Cancerous cells secrete a variety of growth signals to themselves, through autocrine signaling, and to nearby tissues. (jove.com)
  • For example, progesterone appears to act in an autocrine manner in breast cancer, whereby progesterone binds to progesterone receptors on the signaling cell, stimulating the action of growth-promoting genes. (jove.com)
  • Autocrine signaling can also play a role in the development of skin cancer by stimulating the development of new blood vessels that nourish tumor cells. (jove.com)
  • Estimates for the time scale on which signaling takes place and the effective communication distances are needed. (pnas.org)
  • Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-ß signaling. (abcam.com)
  • PCMO responded to both growth factors in an autocrine fashion with intracellular signaling as evidenced by a rise in the levels of phospho-Smad2 and a drop in those of phospho-Smad3. (nih.gov)
  • Inhibition of autocrine activin signaling by either SB431542 or follistatin reduced both Smad2 activation and Oct4A/Nanog upregulation. (nih.gov)
  • Inhibition of autocrine TGF-β signaling by either SB431542 or anti-TGF-β antibody reduced Smad3 activation and strongly increased the number of Ki67-positive cells. (nih.gov)
  • Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell. (wikipedia.org)
  • Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors. (wikipedia.org)
  • Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. (wikipedia.org)
  • Their research showed that autocrine IL-6 signaling induced malignant features in Notch-3 expressing mammospheres. (wikipedia.org)
  • Another agent involved in autocrine cancer signaling is vascular endothelial growth factor (VEGF). (wikipedia.org)
  • One study showed that autocrine PDGFR signaling plays an essential role in epithelial-mesenchymal transition (EMT) maintenance in vitro, which is known to correlate well with metastasis in vivo. (wikipedia.org)
  • The authors showed that the metastatic potential of oncogenic mammary epithelial cells required an autocrine PDGF/PDGFR signaling loop, and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. (wikipedia.org)
  • D) talking to yourself: This would be autocrine signaling. (physicsforums.com)
  • In autocrine signaling the signaling and target cell are physically the same. (physicsforums.com)
  • The process requires innate response activator (IRA) B cells, a transitional B1a-derived inflammatory subset which controls IgM production via autocrine granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. (rupress.org)
  • Defects in cell-cell communication, including the dysregulation of autocrine signaling, are also implied in the development of cancer, and autoimmune and metabolic diseases. (healthcanal.com)
  • Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. (thefullwiki.org)
  • Here we review applications of several of these approaches, including principal component analysis, partial least squares regression, partial least squares discriminant analysis, decision trees, and Bayesian networks, and describe the advances they have offered in systems-level understanding of immune cell signaling and communication. (springer.com)
  • This makes IGF-1 a good protagonist at targeting tissues to spur cell to cell communication (growth) or in a more autocrine cell signaling process that facilitates cell division. (burrillandco.com)
  • Peptide hormone are other class of signaling molecule produced mostly in animals that helps in the cell- cell communication. (assignmenthelp.net)
  • These are lipid signaling molecules that are readily broken down to act either in autocrine or paracrine manner. (assignmenthelp.net)
  • These results suggested that the tumor cells stimulated their growth through an activin A autocrine signaling pathwa, a hypothesis confirmed by activin A secretion in cultured GCT cells which proliferated in response. (aacrjournals.org)
  • However, HPV16 VLP-stimulated IL-12 production by CD8α + CD11c + DCs is augmented by autocrine IFN-γ signaling. (elsevier.com)
  • Cell signaling is the process of cellular communication within the body driven by cells releasing and receiving hormones and other signaling molecules. (altwongqq.com)
Inhibition2
  • The absolute co-expression of ERL1 and MUTE, with the co-presence of EPF1, triggers autocrine inhibition of stomatal fate. (elifesciences.org)
  • During normal stomatal development, this autocrine inhibition prevents extra symmetric divisions of stomatal precursors likely owing to excessive MUTE activity. (elifesciences.org)
Extracellular2
  • Recent work has shown that autocrine signalling is an important checkpoint in immune cell activation and allows immune cells to adjust their functional responses based on the extracellular cues provided by their environment. (nih.gov)
  • Extracellular AMP is hydrolyzed to adenosine by ecto-5'-nucleotidase (eN) as well as by APs. (wikipedia.org)
Receptors3
  • Stimulation of almost all mammalian cell types leads to the release of cellular ATP and autocrine feedback through a diverse array of purinergic receptors. (nih.gov)
  • Depending on the types of purinergic receptors that are involved, autocrine signalling can promote or inhibit cell activation and fine-tune functional responses. (nih.gov)
  • Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss. (burrillandco.com)
Signals3
  • This occurs in the context of T cell-DC communication, during which the DC also delivers costimulatory signals. (jci.org)
  • There are signals set by scientist that makes the process of communication easy and effective. (assignmenthelp.net)
  • and direct communication, which means signals pass inside the cell itself. (altwongqq.com)
Activin1
  • Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β. (nih.gov)
VEGF3
  • Evidence shows that autocrine VEGF is involved in two major aspects of invasive carcinoma: survival and migration. (wikipedia.org)
  • siRNA-based suppression of VEGF expression in a Müller cell line in vitro supports the existence of an autocrine role for VEGF in Müller cell survival.These results indicate an important role for endogenous VEGF in the maintenance and function of adult retina neuronal cells and indicate that anti-VEGF therapies should be administered with caution. (nih.gov)
  • siRNA-based suppression of VEGF expression in a Müller cell line in vitro supports the existence of an autocrine role for VEGF in Müller cell survival. (nih.gov)
Intracellular2
  • Intracellular dialysis of Ang I (10 −8 mol/L) abolished cell communication in myopathic cell pairs with low gj (0.8 to 2.5 nS) and reduced gj by 66±1.7% in the other pairs (7 to 35 nS). (ahajournals.org)
  • Nitric oxide (NO) acts as an autocrine and paracrine mediator in the inter- and intracellular communication between various cell systems. (uni-halle.de)
Cellular communication4
  • Gap junctions allow for cellular communication between cells. (coursehero.com)
  • Neither desmosomes nor tight junctions are associated with cellular communication. (coursehero.com)
  • Cellular communication is a critical component of heterotypic and homotypic interactions in the complex, ever-changing tumor microenvironment. (frontiersin.org)
  • Gap junction proteins are integral membrane proteins present in both vertebrates and invertebrates that participate in cellular communication. (intechopen.com)
Cells14
  • Which form of cell communication is used to relate to other cells in direct physical contact? (coursehero.com)
  • More notably, the transfer of these varied molecules almost invariably plays a critical role in the communication between cancer cells themselves in an effort to resist death by chemotherapy and promote the growth and metastases of the primary oncogenic cell. (frontiersin.org)
  • Cell biology encompasses both prokaryotic and eukaryotic cells and can be divided into many sub-topics which may include the study of cell metabolism, cell communication, cell cycle, biochemistry, and cell composition. (wikipedia.org)
  • Paracrine communication involves chemical messengers between cells within one tissue. (scribd.com)
  • Autocrine cells act on the same cell that produced them. (scribd.com)
  • Cells communicate in ways that are analogous to human communication. (physicsforums.com)
  • Paracrine communication involves local diffusion of regulators from producer cells to distinct target cells within the same organ. (glowm.com)
  • This process is particularly critical during early embryonic development when a cell's differentiation and ultimate fate are controlled by communication with neighboring cells. (healthcanal.com)
  • In their struggle to survive and prosper, multicellular organisms rely on a complex network of communication between cells, which in humans are believed to number about 40 trillion. (riken.jp)
  • Neurons are the cells within the brain that are responsible for rapid communication of information. (thefreelibrary.com)
  • The regulatory response conditions involving IL10 can act in an autocrine manner to suppress the activity of NK cells, macrophages and Th1 cells, all of which are obligatory for pathogen clearance can add to tissue injury. (sciencemag.org)
  • Here, we report that uncontrolled PI3K activity within oocytes irreversibly transforms granulosa cells (GC), causing GC tumors (GCT) through perturbed local cell-communication. (aacrjournals.org)
  • Although communication between the oocyte and surrounding somatic cells is critical for the normal development of ovarian follicles, perturbations in oocyte-GC communication during early folliculogenesis can induce GCT by activating an autocrine growth circuit program in GC. (aacrjournals.org)
  • Q. Communication between cells can occur by all of the following basic mechanisms excepta. (clutchprep.com)
Secretion3
  • Respiration ANS: D NURSINGTB.COM The cell's ability to absorb oxygen is referred to as respiration while its communication ability involves maintenance of a steady dynamic state, metabolic absorption provides nutrition, and secretion allows for the synthesizing of new substances. (coursehero.com)
  • This mode of communication is governed both by physicochemical transport processes and cellular secretion rates, which in turn are determined by genetic and biochemical processes. (pnas.org)
  • Recent research revealed that IL-6 secretion induced by HER2 overexpression activated STAT3 and altered gene expression, resulting in an autocrine loop of IL-6/STAT3 expression. (wikipedia.org)
Physiological1
  • Cell-to-cell communication is a process necessary for physiological tissue homeostasis and appears often altered during disease. (physiology.org)
Ovarian1
  • The ovarian follicle plays an essential role in securing optimal conditions for oocyte maturation and its release during ovulation, for which it will provide an appropriate microenvironment based on locally produced molecules, such as sex steroids and peptide hormones, growth factors, and cytokines, while also providing the appropriate communication among particular compartments of an ovarian follicle [ 3 - 5 ]. (intechopen.com)
Proliferation1
  • Narrowly regulated cell-cell communication plays critical role in the follicle cell proliferation, differentiation, steroidogenesis, oocyte maturation and ovulation. (massgeneral.org)
Neurons1
Hormones1
  • This article will focus on the basic processes underlying neuronal communication and review the neuronal actions of several neurotransmitters, neurotrophic factors, and hormones thought to be involved in the neural actions of alcohol. (thefreelibrary.com)
Role1
  • 23 Previous studies 24 indicated that the RAS plays an important role in the modulation of cell-to-cell communication in normal rat heart. (ahajournals.org)
Survival2
  • Competition experiments showed that the IL-2 produced under the control of CD27 supported effector CD8 + T cell survival in the lungs in an autocrine manner. (jci.org)
  • One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. (wikipedia.org)
Cytokines1
  • During bacterial, viral and protozoal infection, the communication between PAMPs and PRRs of APCs directs the development of Th1, Th2 and Treg cell populations, depending on cytokines, chemokine environment and state of co-stimulation. (sciencemag.org)
Monocytes1
  • An example of an autocrine agent is the cytokine interleukin-1 in monocytes. (wikipedia.org)
Cell Communication7
  • Abstract The influence of heart failure on the process of cell communication was investigated in cell pairs isolated from the ventricle of cardiomyopathic hamsters (11 months old) and the results compared with age-matched normal hamsters. (ahajournals.org)
  • However, the underlying molecular mechanisms, cell-cell communication, and autocrine/paracrine factors involved in cellular interplay are largely unknown. (rochester.edu)
  • Besides glucose, the major nutrient factor, inputs from neural and humoral components and intraislet cell-cell communication act together to guarantee an appropriate pancreatic beta-cell function. (nih.gov)
  • Some cell-to-cell communication requires direct cell-cell contact . (thefullwiki.org)
  • Looking forward, new experimental technologies involving single-cell measurements of cytokine expression beckon extension of these modeling techniques to inference of immune cell-cell communication networks, with a goal of aiding development of improved vaccine therapeutics. (springer.com)
  • What are the steps of cell communication? (altwongqq.com)
  • What are the three types of cell communication? (altwongqq.com)
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation | Nature Medicine
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation | Nature Medicine (nature.com)
Autocrine and Paracrine Regulation of the Ovary | Springer for Research & Development
Autocrine and Paracrine Regulation of the Ovary | Springer for Research & Development (rd.springer.com)
Richard Allen Guyer, Ph.D., M.D. | Harvard Catalyst Profiles | Harvard Catalyst
Richard Allen Guyer, Ph.D., M.D. | Harvard Catalyst Profiles | Harvard Catalyst (connects.catalyst.harvard.edu)
Cell Communication Flashcards by | Brainscape
Cell Communication Flashcards by | Brainscape (brainscape.com)
Sue E. Huether, Kathryn L. McCance - Test Bank for Understanding Pathophysiology (6th Ed)-TestBank ( - Understanding...
Sue E. Huether, Kathryn L. McCance - Test Bank for Understanding Pathophysiology (6th Ed)-TestBank ( - Understanding... (coursehero.com)
Chapter 18 part 1.pdf - Chapter 18 The Endocrine System part 1 Activities of the organ systems are coordinated by the nervous...
Chapter 18 part 1.pdf - Chapter 18 The Endocrine System part 1 Activities of the organ systems are coordinated by the nervous... (coursehero.com)
Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine | Cellular & Molecular...
Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine | Cellular & Molecular... (nature.com)
References Anti-Desmin antibody - Cytoskeleton Marker (ab15200) | Abcam
References Anti-Desmin antibody - Cytoskeleton Marker (ab15200) | Abcam (abcam.com)
Systemic VEGF blockade does not alter retinal vessels u | Open-i
Systemic VEGF blockade does not alter retinal vessels u | Open-i (openi.nlm.nih.gov)
Endocrine System | Adrenal Gland (342 views)
Endocrine System | Adrenal Gland (342 views) (scribd.com)
Incubator Program - Resources - Clinical & Translational Science Institute - University of Rochester Medical Center
Incubator Program - Resources - Clinical & Translational Science Institute - University of Rochester Medical Center (urmc.rochester.edu)
Professor Andrea Cooper</span>
Professor Andrea Cooper</span> (www2.le.ac.uk)
Clinical Hemorheology and Microcirculation - Volume Pre-press, issue Pre-press - Journals - IOS Press
Clinical Hemorheology and Microcirculation - Volume Pre-press, issue Pre-press - Journals - IOS Press (content.iospress.com)
Frontiers | Endocrine Crosstalk Between Skeletal Muscle and the Brain | Neurology
Frontiers | Endocrine Crosstalk Between Skeletal Muscle and the Brain | Neurology (frontiersin.org)
Brainflammation: The Role of the Innate Immune System in CNS Disorders | The New York Academy of Sciences
Brainflammation: The Role of the Innate Immune System in CNS Disorders | The New York Academy of Sciences (nyas.org)
Frontiers | The Potential Role of Contraction-Induced Myokines in the Regulation of Metabolic Function for the Prevention and...
Frontiers | The Potential Role of Contraction-Induced Myokines in the Regulation of Metabolic Function for the Prevention and... (frontiersin.org)
In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin
In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin (cun.es)
Recent Publications | Neurosciences | School of Medicine | Case Western Reserve University
Recent Publications | Neurosciences | School of Medicine | Case Western Reserve University (case.edu)
교원검색 | 포항공과대학교
교원검색 | 포항공과대학교 (postech.ac.kr)
Molecular Cancer 1/2015 | springermedizin.de
Molecular Cancer 1/2015 | springermedizin.de (springermedizin.de)
Frontiers | The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia | Physiology
Frontiers | The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia | Physiology (frontiersin.org)
A dictionary of the language of cells | RIKEN
A dictionary of the language of cells | RIKEN (riken.jp)
Implantation | GLOWM
Implantation | GLOWM (glowm.com)
Cell signalling : Wikis (The Full Wiki)
Cell signalling : Wikis (The Full Wiki) (thefullwiki.org)
Frontiers | Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review...
Frontiers | Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review... (frontiersin.org)
Insights into Proteomic Immune Cell Signaling and Communication via Data-Driven Modeling | SpringerLink
Insights into Proteomic Immune Cell Signaling and Communication via Data-Driven Modeling | SpringerLink (link.springer.com)
IJMS | Free Full-Text | The Role of Curcumin in the Modulation of Ageing | HTML
IJMS | Free Full-Text | The Role of Curcumin in the Modulation of Ageing | HTML (mdpi.com)
Molecular and Cellular Oncology News | MD Anderson Cancer Center
Molecular and Cellular Oncology News | MD Anderson Cancer Center (mdanderson.org)