Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone.
The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.
Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.
Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.
Disorders of verbal and nonverbal communication caused by receptive or expressive LANGUAGE DISORDERS, cognitive dysfunction (e.g., MENTAL RETARDATION), psychiatric conditions, and HEARING DISORDERS.
The transfer of information from experts in the medical and public health fields to patients and the public. The study and use of communication strategies to inform and influence individual and community decisions that enhance health.
Equipment that provides mentally or physically disabled persons with a means of communication. The aids include display boards, typewriters, cathode ray tubes, computers, and speech synthesizers. The output of such aids includes written words, artificial speech, language signs, Morse code, and pictures.
Transmission of emotions, ideas, and attitudes between individuals in ways other than the spoken language.
Cellular signaling in which a factor secreted by a cell affects other cells in the local environment. This term is often used to denote the action of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS on surrounding cells.
Those factors, such as language or sociocultural relationships, which interfere in the meaningful interpretation and transmission of ideas between individuals or groups.
The interactions between physician and patient.
A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)
A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.
Cell surface receptors for AUTOCRINE MOTILITY FACTOR, which is the secreted form of GLUCOSE-6-PHOSPHATE ISOMERASE. The receptor has an unusual composition in that it shares some structural similarities with G-PROTEIN-COUPLED RECEPTORS and functions as an ubiquitin protein ligase when internalized.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The transmission of messages to staff and patients within a hospital.
Communication, in the sense of cross-fertilization of ideas, involving two or more academic disciplines (such as the disciplines that comprise the cross-disciplinary field of bioethics, including the health and biological sciences, the humanities, and the social sciences and law). Also includes problems in communication stemming from differences in patterns of language usage in different academic or medical disciplines.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Utilization of all available receptive and expressive modes for the purpose of achieving communication with the hearing impaired, such as gestures, postures, facial expression, types of voice, formal speech and non-speech systems, and simultaneous communication.
A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.
Interactions between health personnel and patients.
The means of interchanging or transmitting and receiving information. Historically the media were written: books, journals, newspapers, and other publications; in the modern age the media include, in addition, radio, television, computers, and information networks.
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.
The interactions between the professional person and the family.
Signal molecules that are involved in the control of cell growth and differentiation.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
The reciprocal interaction of two or more professional individuals.
A mode of communication concerned with inducing or urging the adoption of certain beliefs, theories, or lines of action by others.
The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.
Recording of information on magnetic or punched paper tape.
Sounds used in animal communication.
Culture media containing biologically active components obtained from previously cultured cells or tissues that have released into the media substances affecting certain cell functions (e.g., growth, lysis).
Interaction between the patient and nurse.
Established cell cultures that have the potential to propagate indefinitely.
Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Transmission of information over distances via electronic means.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
The use of persons coached to feign symptoms or conditions of real diseases in a life-like manner in order to teach or evaluate medical personnel.
The adopting or performing the role of another significant individual in order to gain insight into the behavior of that person.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The electronic transmission of radiological images from one location to another for the purposes of interpretation and/or consultation. Users in different locations may simultaneously view images with greater access to secondary consultations and improved continuing education. (From American College of Radiology, ACR Standard for Teleradiology, 1994, p3)
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Elements of limited time intervals, contributing to particular results or situations.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. (1/1262)

The EPH family is the largest subfamily of receptor protein tyrosine kinases, consisting of the EPHA and EPHB subgroups. Ephrin-B1, ephrin-B2, and ephrin-B3 are ligands of the EPHB subgroup and are encoded by the EFNB1, EFNB2, and EFNB3 genes, respectively. We have shown previously that EPHB2 transcripts are expressed in six small cell lung carcinoma (SCLC) cell lines. In this study, we examined the expression of EPHB1, EPHB2, EPHB3, EPHB4, and EPHB6 in 4 SCLC tumor specimens and 14 cell lines including 3 cell lines derived from these tumor specimens. To investigate whether potential autocrine loops of EPHB receptors and ephrin-B ligands exist in SCLC, the expression of EFNB1, EFNB2, and EFNB3 was also examined. Our data show that transcripts encoding multiple members of the EPHB subgroup and the ephrin-B subgroup are coexpressed in SCLC cell lines and tumors. These results suggest that the EPHB subgroup receptor kinases may modulate the biological behavior of SCLC through autocrine and/or juxtacrine activation by ephrin-B ligands that are expressed in the same or neighboring cells.  (+info)

Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. (2/1262)

The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by influenza virus infection and by double-stranded (ds)RNA. This activation results not only in increased antigen presentation and T cell stimulatory capacity, but also in resistance to the cytopathic effect of the virus, mediated by the production of type I interferon, and upregulation of MxA. Because dsRNA stimulates both maturation and resistance, DCs can serve as altruistic antigen-presenting cells capable of sustaining viral antigen production while acquiring the capacity to trigger naive T cells and drive polarized T helper cell type 1 responses.  (+info)

Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1alpha. (3/1262)

PURPOSE: The matrix metalloproteinase gelatinase B is synthesized by cells at the leading edge of the corneal epithelium migrating to heal a wound. Recent data from the authors' laboratory suggest that excessive synthesis contributes to repair defects. The goal of the study reported here was to investigate mechanisms controlling gelatinase B production by corneal epithelial cells. METHODS: Freshly isolated cultures of corneal epithelial cells and early passage stromal fibroblasts from rabbit were used for these studies. RESULTS: In a previous study, it was found that the cytokine interleukin (IL)-1alpha is released into the culture medium of corneal epithelial cells more efficiently when they are plated at low density with limited cell-cell contact than when plated at high density. In this study, we show that production of gelatinase B by these cells is similarly affected by cell plating density. However, it is further demonstrated that these two events are not dependent on one another but occur in parallel: IL-1alpha does not regulate gelatinase B production (synthesis), nor was there evidence that any other secreted autocrine cytokine acts as mediator. Instead, our data suggest that gelatinase B production is downregulated directly by high cell density and indicate a connection to the level of protein kinase C activity. Nevertheless, the anticancer agent suramin, which blocks collagenase synthesis by interfering with autocrine cytokine-receptor interactions, still inhibits synthesis of gelatinase B. CONCLUSIONS: Unlike collagenase synthesis by corneal stromal fibroblasts, production (synthesis) of gelatinase B does not appear to be controlled by secreted autocrine cytokines but can still be inhibited by suramin. Suramin may make an effective therapeutic agent for controlling pathologic overproduction of gelatinase B in corneal ulcers.  (+info)

Pituitary adenylate cyclase-activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells. (4/1262)

There is increasing evidence that hormones play an important role in the control of endothelial cell function and growth by regulating the production of vascular endothelial growth factor (VEGF). VEGF regulates vascular permeability and represents the most powerful growth factor for endothelial cells. In the normal anterior pituitary, VEGF has been detected only in folliculostellate (FS) cells. In the present study, the regulation of the release of VEGF from FS-like mouse TtT/GF cells, and from FS cells of rat pituitary monolayer cell cultures was investigated using a specific VEGF ELISA. Basal release of VEGF was demonstrated in cultures of both TtT/GF cells and rat pituitary cells. Interestingly, the VEGF secretion was stimulated by both forms of pituitary adenylate cyclase-activating polypeptide (PACAP-38 and PACAP-27), indicating that this hypothalamic peptide regulates endothelial cell function and growth within the pituitary. VEGF secretion was also stimulated by interleukin-6 (IL-6) whereas basal, IL-6- and PACAP-stimulated secretion was inhibited by the synthetic glucocorticoid dexamethasone. The inhibitory action of dexamethasone was reversed by the glucocorticoid receptor antagonist RU486, suggesting that in FS cells functional glucocorticoid receptors mediate the inhibitory action of glucocorticoids on the VEGF secretion. The endocrine and auto-/paracrine control of VEGF production in pituitary FS cells by PACAP, IL-6 and glucocorticoids may play an important role both in angiogenesis and vascular permeability regulation within the pituitary under physiological and pathophysiological conditions.  (+info)

Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets. (5/1262)

We compared several responses in thrombin-stimulated and collagen (type I)-stimulated platelets with and without forskolin and inhibitors of autocrine stimulation (IAS: an ADP-removing system of creatine phosphate/creatine phosphokinase, Arg-Gly-Asp-Ser peptide to prevent fibrinogen/fibronectin binding to GPIIb/IIIa, SQ 29.548 as a thromboxane A2 receptor antagonist, cyproheptadine as a serotonin receptor antagonist, BN 52021 as a platelet-activating factor receptor antagonist). The pattern of tyrosine-phosphorylated proteins, the phosphorylation of lipids in the polyphosphoinositide cycle and phosphorylation of pleckstrin (P47) were studied as markers for signal-transducing responses, exposure of CD62 (P-selectin) and CD63 (Glycoprotein 53), as well as secretion of ADP + ATP and beta-N-acetyl-glycosaminidase were studied as final activation responses. Clear differences between thrombin-stimulated and collagen-stimulated platelets were observed. First, practically all protein-tyrosine phosphorylation induced by thrombin was inhibited by IAS, while a partial inhibition was observed for collagen; the phosphorylation due to collagen alone was apparently stimulated by elevation of cAMP. Secondly, the other responses to thrombin were inhibited by increased levels of cAMP, independent of autocrine stimulation. In contrast, only the autocrine part of the collagen-induced responses was inhibited by elevation of cAMP. Thus, the inhibition by elevated cAMP seen in collagen-stimulated platelets seems to be due to removal of the G-protein-mediated activation from secreted autocrine stimulators either by IAS or forskolin. The remaining activity is a pure collagen effect which is not affected by elevated levels of cAMP.  (+info)

Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid. (6/1262)

PURPOSE: Expression of the genes for collagenase and interleukin-1alpha (IL-1alpha) are induced as stromal cells become activated to the repair fibroblast phenotype after injury to the cornea. This investigation examines the mechanisms whereby expression of these genes is inhibited by transforming growth factor-beta (TGF-beta), dexamethasone (DEX), or retinoic acid (RET A). METHODS: A model of freshly isolated cultures of corneal stromal cells and early passage cultures of corneal fibroblasts was used in these studies. This model reproduces the events of stromal cell activation in the corneal wound. RESULTS: In early passage cultures of corneal fibroblasts, expression of collagenase is under obligatory control by autocrine IL-1alpha. IL-1alpha controls its own expression through an autocrine feedback loop that is dependent on transcription factor NF-kappaB. TGF-beta, DEX, and RET A were each effective inhibitors of collagenase gene expression in these cells. Furthermore, these agents have the capacity to inhibit expression of IL-1alpha and this was correlated with their ability to affect DNA-binding activity of NF-kappaB. However, TGF-beta, DEX, and RET A were also effective inhibitors of the low level of collagenase expressed by freshly isolated corneal stromal cells that cannot express IL-1alpha. CONCLUSIONS: In cells with an active IL-1alpha autocrine loop there are at least two distinct signaling pathways by which collagenase gene expression can be modulated. The results of this study demonstrate that TGF-beta, DEX, and RET A differentially inhibit collagenase and IL-1alpha gene expression. This information will be useful in the design of therapeutic modalities for fibrotic disease in the cornea and other parts of the eye.  (+info)

The role of macrophage cell death in tuberculosis. (7/1262)

Studies of host responses to infection have traditionally focused on the direct antimicrobial activity of effector molecules (antibodies, complement, defensins, reactive oxygen and nitrogen intermediates) and immunocytes (macrophages, lymphocytes, and neutrophils among others). The discovery of the systems for programmed cell death of eukaryotic cells has revealed a unique role for this process in the complex interplay between microorganisms and their cellular targets or responding immunocytes. In particular, cells of the monocyte/macrophage lineage have been demonstrated to undergo apoptosis following intracellular infection with certain pathogens that are otherwise capable of surviving within the hostile environment of the phagosome or which can escape the phagosome. Mycobacterium tuberculosis is a prototypical 'intracellular parasite' of macrophages, and the direct induction of macrophage apoptosis by this organism has recently been reported from several laboratories. This paper reviews the current understanding of the mechanism and regulation of macrophage apoptosis in response to M. tuberculosis and examines the role this process plays in protective immunity and microbial virulence.  (+info)

Ligation of Fc gamma RII (CD32) pivotally regulates survival of human eosinophils. (8/1262)

The low-affinity IgG Fc receptor, FcgammaRII (CD32), mediates various effector functions of lymphoid and myeloid cells and is the major IgG Fc receptor expressed by human eosinophils. We investigated whether FcgammaRII regulates both cell survival and death of human eosinophils. When cultured in vitro without growth factors, most eosinophils undergo apoptosis within 96 h. Ligation of FcgammaRII by anti-CD32 mAb in solution inhibited eosinophil apoptosis and prolonged survival in the absence of growth factors. Cross-linking of human IgG bound to FcgammaRII by anti-human IgG Ab or of unoccupied FcgammaRII by aggregated human IgG also prolonged eosinophil survival. The enhanced survival with anti-CD32 mAb was inhibited by anti-granulocyte-macrophage-CSF (GM-CSF) mAb, suggesting that autocrine production of GM-CSF by eosinophils mediated survival. In fact, mRNA for GM-CSF was detected in eosinophils cultured with anti-CD32 mAb. In contrast to mAb or ligands in solution, anti-CD32 mAb or human IgG, when immobilized onto tissue culture plates, facilitated eosinophil cell death even in the presence of IL-5. Cell death induced by these immobilized ligands was accompanied by DNA fragmentation and was inhibited when eosinophil beta2 integrin was blocked by anti-CD18 mAb, suggesting that beta2 integrins play a key role in initiating eosinophil apoptosis. Thus, FcgammaRII may pivotally regulate both survival and death of eosinophils, depending on the manner of receptor ligation and beta2 integrin involvement. Moreover, the FcgammaRII could provide a novel mechanism to control the number of eosinophils at inflammation sites in human diseases.  (+info)

Some common types of communication disorders include:

1. Speech disorders: These are conditions that affect an individual's ability to produce speech sounds correctly or fluently. Examples include stuttering, articulation disorders, and apraxia of speech.
2. Language disorders: These are conditions that affect an individual's ability to understand and use language effectively. Examples include agrammatism (difficulty with sentence structure), anomia (word-finding difficulties), and semantic-dyslexia (difficulty with word meaning).
3. Reading disorders: These are conditions that affect an individual's ability to read and spell written words. Examples include dyslexia and other reading disabilities.
4. Hearing impairments: These are conditions that affect an individual's ability to hear or process sound. Examples include conductive hearing loss, sensorineural hearing loss, and auditory processing disorders.
5. Cognitive communication disorders: These are conditions that affect an individual's ability to think, reason, and understand language. Examples include traumatic brain injury, dementia, and neurodegenerative diseases such as Alzheimer's and Parkinson's.

The symptoms of communication disorders can vary depending on the specific condition and the individual affected. Some common symptoms include:

* Difficulty articulating words or sounds
* Slurred or slow speech
* Difficulty understanding spoken language
* Difficulty with word-finding
* Difficulty with reading and spelling
* Difficulty with comprehending written text
* Difficulty with nonverbal communication such as gestures and facial expressions

Communication disorders can be diagnosed by a speech-language pathologist (SLP) through a series of tests and assessments. Treatment options for communication disorders vary depending on the specific condition and the individual affected, but may include:

* Speech and language therapy to improve articulation, fluency, and comprehension skills
* Cognitive therapy to improve memory, attention, and problem-solving skills
* Use of technology such as hearing aids or communication devices
* Counseling and support for individuals and their families.

It is important to seek professional help if you or someone you know is experiencing difficulty with communication. With appropriate diagnosis and treatment, individuals with communication disorders can improve their communication skills and lead fulfilling lives.

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Autocrine is a cell sending a signal to itself by secreting a molecule that binds to a receptor on its surface. Forms of ... Cell signaling or cell communication is important for cell regulation and for cells to process information from the environment ... Signaling can occur through direct cell contact or endocrine, paracrine, and autocrine signaling. Direct cell-cell contact is ... cell communication, cell cycle, biochemistry, and cell composition. The study of cells is performed using several microscopy ...
"Model of autocrine/paracrine signaling in epithelial layer: geometrical regulation of intercellular communication". J Phys Chem ...
... s use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are ... Wnt is down-regulated during the dormancy stage by autocrine Dkk1 to avoid immune surveillance, as well as during the ... In Wnt signaling, these proteins act as ligands to activate the different Wnt pathways via paracrine and autocrine routes. ... Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.Int. J. Cancer ...
There are generally four types of chemical signals: autocrine, paracrine, juxtacrine, and hormones. In autocrine signaling, the ... Cell signaling (or communication) is the ability of cells to receive, process, and transmit signals with its environment and ... "Cell communication". Nature Education. Archived from the original on 29 September 2010. Retrieved 29 May 2021. "Cell signaling ... Intracellular signals consist of a cell signaling itself (autocrine signaling), also play a role in organ formation. These ...
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Autocrine purinergic signalling is an important checkpoint in the activation of white blood cells. These mechanisms either ... It has an excitatory effect on neurones, and acts as a mediator in neuronal-glial communications. Both adenosine and ATP induce ... The release of ATP and an autocrine feedback through P2RY2 and A3 receptors are signal amplifiers. Hypoxia-inducible factors ... Although purinergic signaling has been connected to pathological processes in the context of neuron-glia communication, it has ...
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine ... Autocrine+signaling at the US National Library of Medicine Medical Subject Headings (MeSH) "Autocrine versus juxtacrine ... and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR ...
... is a form of cell signaling, a type of cellular communication in which a cell produces a signal to induce ... and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. ...
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... and Autocrine Regulation of Structure and Functions, Cellular And Molecular Biology For Human, (all on Cell and Molecular ... and Intercellular Communication. Science Publishers. ISBN 978-1-57808-066-3. "Guraya SS[au] on Pubmed". Pubmed. 2016. Retrieved ... and Autocrine Regulation of Structure and Functions. Science Publishers. ISBN 978-1-57808-165-3. Sardul S. Guraya (1 January ... and Autocrine Regulation of Structure and Functions. Science Publishers. ISBN 978-1-57808-165-3. Sardul S. Guraya (1 January ...
Recent studies have shown the existence of communication between adherens junctions and gap junctions, suggesting a higher ... connexin hemichannels and pannexin channels can contribute to autocrine/paracrine signaling pathways, and (3) different ... "Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by ... "Characterization of gap junctional intercellular communication in immortalized human pancreatic ductal epithelial cells with ...
This definition holds for most "classical" hormones, but there are also paracrine mechanisms (chemical communication between ... cells within a tissue or organ), autocrine signals (a chemical that acts on the same cell), and intracrine signals (a chemical ...
... autocrine communication MeSH G04.335.122.155 - bystander effect MeSH G04.335.122.300 - embryonic induction MeSH G04.335.122.600 ... paracrine communication MeSH G04.335.122.850 - signal transduction MeSH G04.335.122.850.580 - mechanotransduction, cellular ...
"Cell-to-cell communication in the anterior pituitary: evidence for gap junction-mediated exchanges between endocrine cells and ... autocrine/paracrine control of anterior pituitary cell function though the use of cytokines and growth factors, intrapituitary ... as the IL-6 is a mediator in communication between the endocrine and immune system. IL-6 production by FS cells induces hormone ... A route for long-distance communication in the anterior pituitary". Proceedings of the National Academy of Sciences. 98 (15): ...
The hormone acts in endocrine, autocrine, and paracrine manners through the prolactin receptor and numerous cytokine receptors ... Nature Communications. 5: 5861. Bibcode:2014NatCo...5.5861L. doi:10.1038/ncomms6861. PMC 4284646. PMID 25519203. Porto-Neto LR ... an autocrine growth factor for lymphoproliferation". Proceedings of the National Academy of Sciences of the United States of ... where they regulate hair growth and moulting in an autocrine fashion. Elevated levels of prolactin can inhibit hair growth, and ...
Her work on cell-to-cell communication has also focused on the mechanisms that determine organ size and shape. In September ... "Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling". eLife. 6: ... Torii researches stem cell maintenance and the cell-to-cell communication required to correctly pattern tissue during ... Chemical Communications. 53 (69): 9632-9635. doi:10.1039/C7CC04526C. PMID 28809975. Hirakawa, Yuki; Shinohara, Hidefumi; Welke ...
This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. Epigenetic regulation ... Biochemical and Biophysical Research Communications. 198 (3): 983-989. doi:10.1006/bbrc.1994.1140. PMID 8117306. Maruyama K, ... "Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone ... "Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone ...
"Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling" ( ... Biochemical and Biophysical Research Communications. 215 (2): 737-43. doi:10.1006/bbrc.1995.2525. PMID 7488016. Schweickart VL ...
... and role in autocrine cell growth of cell surface retention sequence binding protein-1". The Journal of Biological Chemistry. ... Biochemical and Biophysical Research Communications. 288 (4): 1043-6. doi:10.1006/bbrc.2001.5869. PMID 11689016. Mouta Carreira ...
Autocrine signaling involves a cell secreting a hormone or chemical messenger (called the autocrine agent) that binds to ... "The Inside Story of Cell Communication". learn.genetics.utah.edu. Retrieved 2018-10-20. "When Cell Communication Goes Wrong". ... Estrogen can be released by the ovary and function as a hormone or act locally via paracrine or autocrine signaling. Although ... "Cell communication". Nature Education. Retrieved 29 May 2021. "Cell signaling". Nature Education. Retrieved 29 May 2021. Vu TQ ...
Autocrine signaling is a form of signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent ... Juxtacrine signaling is a type of intercellular communication that is transmitted via oligosaccharide, lipid, or protein ... Endocrine, paracrine, and autocrine signaling have all been implicated in proliferation, one of the required steps of ... The term hormone is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or ...
2003). "Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding ... Biochemical and Biophysical Research Communications. 288 (4): 1043-1046. doi:10.1006/bbrc.2001.5869. PMID 11689016. Mouta ...
"Autocrine versus juxtacrine signaling modes" - illustration at sysbio.org (Use dmy dates from July 2021, Articles with short ... 2002). "General Principles of Cell Communication". In NCBI bookshelf (ed.). Molecular biology of the cell (4th ed.). New York: ... Paracrine signaling occurs over short distances, while autocrine signaling involves a cell responding to its own paracrine ... Other types of cell signaling include paracrine signalling and autocrine signalling. ...
Recently, co-culture has become the predominant approach to study the effect of cellular communication by culturing two ... autocrine signaling, and juxtacrine signaling. For example, in paracrine signaling, growth factors secreted from one cell ... Bogdanowicz DR, Lu HH (April 2013). "Studying cell-cell communication in co-culture". Biotechnology Journal. 8 (4): 395-6. doi: ... cells can engage in enhanced communication with neighboring cells and cell-extracellular matrix interactions can be modeled. In ...
These growth factors often act in a paracrine or autocrine fashion; they include fibroblast growth factor, placental growth ... requiring precise coordination of multiple steps and the participation and communication of multiple cell types. The complex ...
"AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF". ... Biochemical and Biophysical Research Communications. 448 (3): 287-91. doi:10.1016/j.bbrc.2014.04.106. PMID 24796669. Cano- ... Biochemical and Biophysical Research Communications. 228 (1): 29-37. doi:10.1006/bbrc.1996.1612. PMID 8912632. "Entrez Gene: ... Biochemical and Biophysical Research Communications. 286 (2): 292-7. doi:10.1006/bbrc.2001.5388. PMID 11500035. Autieri MV, ...
Choy L, Skillington J, Derynck R (May 2000). "Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte ... Nature Communications. 10 (1): 2757. Bibcode:2019NatCo..10.2757G. doi:10.1038/s41467-019-10688-x. PMC 6588633. PMID 31227697. ( ...
Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.Int. J. Cancer ... Biochemical and Biophysical Research Communications. 402 (4): 711-7. doi:10.1016/j.bbrc.2010.10.091. PMC 2998991. PMID 20977885 ... January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5 ...
VIP acts in an autocrine fashion via VPAC11 to inhibit megakaryocyte proliferation and induce proplatelet formation. Patients ... Biochemical and Biophysical Research Communications. 200 (2): 769-76. doi:10.1006/bbrc.1994.1517. PMID 8179610. Moody TW, Zia F ... Biochemical and Biophysical Research Communications. 206 (1): 246-52. doi:10.1006/bbrc.1995.1034. PMID 7818527. Gagnon AW, ... Biochemical and Biophysical Research Communications. 203 (1): 141-8. doi:10.1006/bbrc.1994.2160. PMID 8074647. Couvineau A, ...
Kelley used these data to strongly advance the concept of communication networks between the brain and the immune system. This ... Prolactin synthesized and secreted by human peripheral blood mononuclear cells: An autocrine growth factor for ... He is considered as an international authority on reciprocal communication systems between the immune system and brain. His ... In his research, he used two approaches to prove the existence of important neuroendocrine-immune communication systems: ...
It has been shown that autocrine TGF-β signaling is a compensatory result of mechanical stress in vitro in endothelial cells. ... Biochemical and Biophysical Research Communications. 265 (3): 680-90. doi:10.1006/bbrc.1999.1714. PMID 10600481. SundarRaj N, ... This is contingent upon TGF-β autocrine signaling in a positive feedback loop with p38 and ERK. This endothelial cell increase ... Aviezer D, Iozzo RV, Noonan DM, Yayon A (April 1997). "Suppression of autocrine and paracrine functions of basic fibroblast ...
... while retaining its function as an autocrine motility factor. Hence when a mutation takes place that inactivates a function of ... Nature Communications. 5: 4730. Bibcode:2014NatCo...5.4730B. doi:10.1038/ncomms5730. PMID 25163484. (CS1: long volume value, ... Biochemical and Biophysical Research Communications. 158 (1): 319-25. doi:10.1016/S0006-291X(89)80215-3. PMID 2912453. Kato K, ...
Wnt ligands are classically described as acting in an autocrine/paracrine manner. Wnts are also hydrophobic with significant ... Biochemical and Biophysical Research Communications. 263 (2): 384-8. doi:10.1006/bbrc.1999.1344. PMID 10491302. Gazit A, Yaniv ... Anagnostou SH, Shepherd PR (December 2008). "Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in ...
This form of cancer has been identified with autocrine growth loops, proto-oncogene activation and inhibition of tumour ... December 2020). "Role of Carbon Monoxide in Host-Gut Microbiome Communication". Chemical Reviews. 120 (24): 13273-13311. doi: ...
In multicellular organisms, signal transduction pathways regulate cell communication in a wide variety of ways. Each component ... First messengers are the signaling molecules (hormones, neurotransmitters, and paracrine/autocrine agents) that reach the cell ... while the terms autocrine and paracrine began to be used. Sutherland was awarded the 1971 Nobel Prize in Physiology or Medicine ... Biochemical and Biophysical Research Communications. 319 (1): 1-11. doi:10.1016/j.bbrc.2004.04.150. PMID 15158434. Wolanin PM, ...
The autocrine CXCL9/CXCR3 signaling in cancer cells increases cancer cell proliferation, angiogenesis, and metastasis.[citation ... Biochemical and Biophysical Research Communications. 192 (1): 223-30. doi:10.1006/bbrc.1993.1403. PMID 8476424. Erdel M, Laich ...
Both the overexpression of Met/HGFR, as well as its autocrine activation by co-expression of its hepatocyte growth factor ... one with autism and the other with a social and communication disorder. The role of the receptor in brain development is ... Kochhar KS, Johnson ME, Volpert O, Iyer AP (1995). "Evidence for autocrine basis of transformation in NIH-3T3 cells transfected ... Nature Communications. 7: 11942. doi:10.1038/ncomms11942. PMC 4931016. PMID 27336951. Rappolee DA, Iyer A, Patel Y (June 1996 ...
As such, succinate links TCA cycle dysfunction or metabolic changes to cell-cell communication and to oxidative stress-related ... Autocrine succinate signaling promotes retinal neovascularization, triggering the activation of angiogenic factors such as ... Cell Communication and Signaling. 14: 3. doi:10.1186/s12964-016-0126-1. PMC 4709936. PMID 26759054. Bardella, Chiara; Pollard, ...
2016: Autocrine secretion of hPG80 promotes survival and self-renewal of stem cells in colon cancer. 2017: The use of ... Biochemical and Biophysical Research Communications. 336 (1): 190-196. doi:10.1016/j.bbrc.2005.08.061. ISSN 0006-291X. PMID ... These observations led to the study of autocrine and paracrine function of hPG80 in tumor cells. Generally, it has been shown ... "Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells". Cancer Research. 76 ...
Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistancein mesothelioma initiating cells by inducing ABCB5.Int. J. Cancer, ... Nature Communications. 2 (1): 162. Bibcode:2011NatCo...2..162R. doi:10.1038/ncomms1159. PMC 3105310. PMID 21245843. Li T, Su Y ... January 2020). "Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5 ... Nature Communications. 11 (1): 1961. Bibcode:2020NatCo..11.1961C. doi:10.1038/s41467-020-15846-0. PMC 7181628. PMID 32327656. ...
2001-12-15). "Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells". Cancer Research. 61 ( ... Biochemical and Biophysical Research Communications. 320 (2): 493-500. doi:10.1016/j.bbrc.2004.06.003. PMID 15219856. Miyashita ...
Communication between endothelial cells and pericytes is vital. Inhibiting the PDGF pathway leads to pericyte deficiency. This ... "Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression". Blood. 118 ( ... The apoptosis of pericytes in the aging brain may be the result of a failure in communication between growth factors and ... Endothelial cells and pericytes are interdependent and failure of proper communication between the two cell types can lead to ...
Xie J, Zhang H, Yea K, Lerner RA (May 2013). "Autocrine signaling based selection of combinatorial antibodies that ... January 2016). "Human pancreatic beta-like cells converted from fibroblasts". Nature Communications. 7: 10080. Bibcode: ... Nature Communications. 4: 2307. Bibcode:2013NatCo...4.2307L. doi:10.1038/ncomms3307. PMID 23942048. Mohamed TM, Stone NR, Berry ... Nature Communications. 5: 3338. Bibcode:2014NatCo...5.3338S. doi:10.1038/ncomms4338. PMC 3966078. PMID 24569435. Najm FJ, Lager ...
Nakano, Tadashi; Eckford, Andrew W.; Haraguchi, Tokuko (12 September 2013). Molecular Communication. Cambridge University Press ... integrins are also receptive to autocrine and paracrine signals such as growth factors in the TGF-beta family. Chondrocytes ... this secretion may be a mechanism for autocrine signal amplification within the tissue. Integrin signaling is just one example ...
LMW FGF2 is primarily cytoplasmic and functions in an autocrine manner, whereas HMW FGF2s are nuclear and exert activities ... Biochemical and Biophysical Research Communications. 261 (3): 756-65. doi:10.1006/bbrc.1999.1039. PMID 10441498. Kirikoshi H, ... Biochemical and Biophysical Research Communications. 274 (2): 337-43. doi:10.1006/bbrc.2000.3142. PMID 10913340. Potthoff MJ, ...
Studies using TG mice model suggested the existence of an autocrine loop involving the CDK-cyclin D1-PELP1 axis in promoting ... Nature Communications. 4: 1923. Bibcode:2013NatCo...4.1923R. doi:10.1038/ncomms2912. PMID 23715282. PELP1 protein, human at the ... potential estrogen receptor autocrine signaling loop in breast cancer cells". Molecular Endocrinology. 22 (3): 649-64. doi: ...
Targeting an autocrine IL-6-SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma. 14 September ... Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP ... Peer review information: Nature Communications thanks Marilena Loizidou, Joanne Richards and Dean Yimlamai for their ... Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP ...
Autocrine Communication G4.299.122.100 G4.85.100 Autoimmune Hypophysitis C10.228.140.617.738.100 C10.228.140.617.738.275.500 ... Cell Communication G4.299.122 G4.85 Cell Compartmentation G4.299.125 G4.128 Cell Count G4.170 G4.140 Cell Cycle G4.299.134 ... Manual Communication E2.760.169.63.500.200.609 Manubrium A2.835.232.904.766.442 A2.835.232.570.750.442 MAP Kinase Signaling ... Autocrine Motility Factor D12.776.543.750.68 D12.776.543.750.660 Receptors, Biogenic Amine D12.776.543.750.69 D12.776.543.750. ...
... personal communication). Similarly, an activating Tie-2 mutation causes venous malformations that are composed of dilated ... Moreover, the data identify Ang-2 as a rapid autocrine regulator of vascular stability that acts through an internal autocrine ... However, autocrine Ang-2-mediated endothelial-cell detachment cannot be blocked by soluble Tie-2. Taken together, the data ... The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism Marion ...
Autocrine Communication; Carcinogens; Coculture Techniques; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; ... In this study, we focused on the paracrine and autocrine regulation of interleukin (IL)-8 expression in sensitized lung cancer ... Our results highly suggest that both autocrine and paracrine regulation are involved in IL-8 expression of lung cancer cells ... Autocrine and paracrine regulation of interleukin-8 expression in lung cancer cells. en_US. ...
Autocrine Communications Autocrine Signaling Autocrine Signalings Communication, Autocrine Communications, Autocrine Signaling ... Autocrine Communications. Autocrine Signaling. Autocrine Signalings. Communication, Autocrine. Communications, Autocrine. ... Autocrine Communication - Preferred Concept UI. M0029554. Scope note. Mode of communication wherein a bound hormone affects the ... Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone.. ...
Autocrine STIP1 signaling promotes tumor growth and is associated with disease outcome in hepatocellular carcinoma. Chen, Z., ... Nature communications. 9, 1, 4962.. Research output: Contribution to journal › Article › peer-review ... Autocrine VEGF signaling promotes proliferation of neoplastic barretts epithelial cells through a PLC-dependent pathway. Zhang ... Biochemical and Biophysical Research Communications. 493, 1, p. 365-372 8 p.. Research output: Contribution to journal › ...
Conclusion: This study demonstrated the communication within PTECs through exosome transmission in an autocrine pattern. MiR- ... Autocrine Exosomal Fibulin-1 as a Target of MiR-1269b Induces Epithelial-Mesenchymal Transition in Proximal Tubule in Diabetic ... Exosomes deliver biomolecule massages and may play a key role in cell communication and the progression of DN. Methods: A cross ... Information of cell-cell communication within the kidney was obtained using receptor-ligand pairing resources. In vitro model, ...
Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell Signal. 2005;17:1183-93. ... Lim WA, Pawson T. Phosphotyrosine signaling: evolving a new cellular communication system. Cell. 2010;142:661-7. ...
An autocrine respite of the induced incident could down let proposed on this server. An small search of the confirmed staff ... interior Cardiac communication: request time design. It persists that this is vivo temporarily on file. Chan and Chen Greif and ... Pagan and Russell Jacobs and R. The download essentials of business communication book only adds one of the areas of the IBM ... Nov 2014) COMMUNICATIONS. IEEE INTERNATIONAL CONFERENCE. 12 VOLS)DESIGN AUTOMATION AND TEST IN EUROPE. 3 VOLS)WIRELESS AND ...
In the anterior pituitary, paracrine communication and autocrine loops that operate during fetal and postnatal development in ... Cell signalling can also be self-targeting or autocrine. Although the notion of paracrine and autocrine signalling was already ... Paracrine/autocrine actions are highly context-dependent. They are turned on/off when hormonal outputs need to be adapted to ... Taken together, these data outline the potential role of apelin as an autocrine/paracrine-acting peptide on ACTH release and ...
PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis. Nature cell ... Nature Communications Dec 16, 2019 * A New Switch for TGFβ in Cancer. Cancer Research Jul 12, 2019 ...
Acta Neuropathologica Communications volume 8, Article number: 221 (2020) Cite this article ... Ikushima H, Todo T, Ino Y, Takahashi M, Miyazawa K, Miyazono K (2009) Autocrine TGF-beta signaling maintains tumorigenicity of ...
MGF does not circulate in the blood, but instead acts on locally targeted muscle tissue as an autocrine/paracrine signal, ... This sort of tight coupling between communication and regulation exists in many biological contexts, underlining the importance ... For purposes of clarification, autocrine and paracrine substances act on the cell that secreted them and neighboring cells, ... Overlooked, however, was the importance of the autocrine/paracrine local response, with alternate pathways that concern ...
This makes IGF-1 a good protagonist at targeting tissues to spur cell to cell communication (growth) or in a more autocrine ... binding to receptors and activating cell communication that improves muscle growth and fat loss. ...
The role of fibroblast growth factor receptor 2 (FGFR2), an important mediator of stromal paracrine and autocrine signals, in ... In vitro analyses demonstrated that FGFR2 regulates epithelial cell communication with extracellular matrix (ECM) proteins. ...
Autocrine Communication G4.299.122.100 G4.85.100 Autoimmune Hypophysitis C10.228.140.617.738.100 C10.228.140.617.738.275.500 ... Cell Communication G4.299.122 G4.85 Cell Compartmentation G4.299.125 G4.128 Cell Count G4.170 G4.140 Cell Cycle G4.299.134 ... Manual Communication E2.760.169.63.500.200.609 Manubrium A2.835.232.904.766.442 A2.835.232.570.750.442 MAP Kinase Signaling ... Autocrine Motility Factor D12.776.543.750.68 D12.776.543.750.660 Receptors, Biogenic Amine D12.776.543.750.69 D12.776.543.750. ...
QUESTION 85 (3 marks) There are different types of cell signaling used in cell communication, like endocrine , paracrine, ... autocrine and contact-dependent signaling Select two of these cell signaling types and describe how each function to relay ... QUESTION 85 (3 marks) There are different types of cell signaling used in cell communication, like endocrine , paracrine, ... autocrine and contact-dependent signaling Select two of these cell signaling types and describe how each function to relay ...
... and communication. In this study, we demonstrated that metformin plus DQ recovered ovarian function to a greater extent ... M. Ogrodnik, S. Miwa, T. Tchkonia et al., "Cellular senescence drives age-dependent hepatic steatosis," Nature Communications, ... SASPs serve as mediators and spread senescence or senescence phenotypes in autocrine and paracrine fashions, thus interfere ... and cell signal communication (Figure 6(e)). The above comparative analysis of cisplatin and senotherapeutic DEGs in the ...
Electrical stimulation of sympathetic neurons induces autocrine/paracrine effects of NGF mediated by TrkA [med./bio.] ... Risk communication * Dialog in risk communication * Tools of risk communication * Risk perception ...
Park, H. L., Kim, H. K., Chung, C. H., Chang, S. K. & Yu, J. T., 1989 Feb, In: Solid State Communications. 69, 7, p. 765-767 3 ... Tumor necrosis factor acts synergistically with autocrine interferon-β and increases interferon-β mRNA levels in human ...
Signaling Network of Podocyte Aging: As the kidney ages, the cells establish new autocrine and paracrine signaling loops. Using ... strong written and verbal communication skills and experience in cell and/or molecular biology. Postdoc candidates will be ...
Autocrine Communication. *Base Sequence. *Benzamides. *Binding Sites. *Biological Transport. *Biomarkers. *Biomarkers, Tumor ...
understand a Autocrine Cancel ebook americas most must use been in to obtain a user. For, rights awarded, any 2-way download ... The gift world, the term&mdash, arrived its easy averse subscription in Rosemont, Illinois, on June communication; 11, 2008, to ... the solo could legally have the systemConference over a command book at a purchase to see a communication. To ameliorate this, ... Follow your place treatment without communication. use you enable the parent to signaling any potent pain. See it inside this ...
PDGF receptors-mediators of autocrine tumor growth. Search. Main menu. Skip to primary content ... RANKL also regulates T cell/dendritic cell communications, dendritic cell survival and lymph node organogenesis. Intriguingly, ...
Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage NATURE COMMUNICATIONS Chavez, S. L., Loewke, K ... Promotion of Human Early Embryonic Development and Blastocyst Outgrowth In Vitro Using Autocrine/Paracrine Growth Factors PLOS ... Previously uncharacterized rectangular bacterial structures in the dolphin mouth. Nature communications Dudek, N. K., Galaz- ... Nature communications Yanez, L. Z., Han, J., Behr, B. B., Reijo Pera, R. A., Camarillo, D. B. 2016; 7: 10809-? Abstract. The ...
Griffin j, wilson j. Disorders of orgasm on endo- crine and autocrine factors can increase the rate of copulation, and decrease ... Adults in five years ago that the gas nitric oxide synthase to the ventral stream of visual communication, 3: 39 47. ...
VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer Oncogenic BRAF regulates oxidative metabolism via PGC1α ... a novel biomarker for early diagnosis Communication through resonance in spiking neuronal networks Bleb-driven chemotaxis of ... and heterosynaptic plasticity Autocrine BDNF TrkB signalling within a single dendritic spine Mycoplasma pneumoniaetriggering ... DNA damage in human skin cells High IFN-γ and low SLPI mark severe asthma in mice and humans Cell-cell communication in yeast ...
7. Haass NK, Smalley KS, Herlyn M. The Role of Altered Cell-Cell Communication in Melanoma Progression. J Mol Histol (2004) 35: ... Therefore, not only paracrine and autocrine mechanisms, but intracrine signalling is also feasible in malignant pigment cells, ... In addition, as melanoma cells can produce PACAP, paracrine, autocrine and intracrine regulatory mechanisms are all possible. ... rather than an autocrine PACAP signalling loop (45). On the other hand, the expression of DPP4, the enzyme that is responsible ...
Graeber TG, Eisenberg D. Bioinformatic identification of potential autocrine signaling loops in cancers from gene expression ... Short Communication - Journal of Biomedical Imaging and Bioengineering (2023) Volume 7, Issue 2 ...
... loss of mfsd8 altered lysosomal enzymatic activities and reduced the intracellular and extracellular levels of autocrine ... crisis of the paternal metaphor along with the problems of the futurity and the disruption of intergenerational communication ...
  • Cytokines are protein mediators of intercellular stress communication with autocrine, paracrine, and endocrine modes of action. (diabetesjournals.org)
  • In this study, we focused on the paracrine and autocrine regulation of interleukin (IL)-8 expression in sensitized lung cancer cells after interacting with macrophages. (ntu.edu.tw)
  • Our results highly suggest that both autocrine and paracrine regulation are involved in IL-8 expression of lung cancer cells cocultured with macrophage. (ntu.edu.tw)
  • Electrical stimulation of sympathetic neurons induces autocrine/paracrine effects of NGF mediated by TrkA [med. (emf-portal.org)
  • As the kidney ages, the cells establish new autocrine and paracrine signaling loops. (careeraddict.com)
  • These neurons then secrete CPE/NF-α1 to protect them from glutamate- induced cell death in an autocrine/paracrine manner. (nih.gov)
  • Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension. (nih.gov)
  • Endothelial autocrine signaling is essential to maintain vascular homeostasis. (nih.gov)
  • There is limited information about the role of endothelial autocrine signaling in regulating severe pulmonary vascular remodeling during the onset of pulmonary arterial hypertension (PAH). (nih.gov)
  • In this study, we employed the first severe pulmonary hypertension (PH) mouse model, Egln1Tie2Cre (Tie2Cre-mediated disruption of Egln1) mice, to identify the novel autocrine signaling mediating the pulmonary vascular endothelial cell (PVEC) proliferation and the pathogenesis of PAH. (nih.gov)
  • This makes IGF-1 a good protagonist at targeting tissues to spur cell to cell communication (growth) or in a more autocrine cell signaling process that facilitates cell division. (bulkingcyclesteroids.com)
  • Besides helping us refine techniques to improve gene transfer efficiency into murine stem cells, these studies also provided insight into the possible roles of autocrine growth factor production in myeloproliferative diseases and leukemias, and further work defined a possible intracellular autocrine pathway for IL-3 signaling. (nih.gov)
  • However, autocrine Ang-2-mediated endothelial-cell detachment cannot be blocked by soluble Tie-2. (biologists.com)
  • Intercellular communication of blood, vascular and heart cells. (nih.gov)
  • 2014. Effector CD4 T cell transition to memory requires late cognate interactions that induce autocrine IL-2. (ucf.edu)
  • In 2004 he oversaw the relocation of administrative and extramural offices, and NIAAA intramural laboratories to newly-built quarters on Fishers Lane in Rockville, MD. The new buildings have been a welcome upgrade for NIAAA staff and have helped to improve communications and interactions across NIAAA intramural and extramural divisions. (nih.gov)
  • Gene ontology analysis further revealed that combining senotherapies enhanced ovarian cell differentiation, development, and communication. (hindawi.com)
  • Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone. (nih.gov)
  • Information of cell-cell communication within the kidney was obtained using receptor-ligand pairing resources. (bvsalud.org)
  • Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss. (bulkingcyclesteroids.com)
  • The successful applicant should demonstrate a commitment to research, a collaborative work ethic, strong written and verbal communication skills and experience in cell and/or molecular biology. (careeraddict.com)
  • Nature Communications 5:5377 doi: 10.1038/ncomms6377. (ucf.edu)
  • Ang-2 is mainly produced by endothelial cells and therefore acts primarily in an autocrine manner. (biologists.com)
  • Taken together, the data demonstrate for the first time the antagonistic Ang-1/Ang-2 concept in a defined cellular model and identify Ang-2 as a rapidly acting autocrine regulator of the endothelium that acts through an internal autocrine loop mechanism. (biologists.com)
  • This study firstly demonstrated the communication between proximal tubular epithelial cells (PTECs) and mesangial cells (MCs) through exosome transmission. (bvsalud.org)
  • and c ) whether preestablished insulin resistance alters the metabolic responses of adipocytes exposed to PCB126 and the communication between adipocytes and myotubes. (nih.gov)
  • These hormones regulate the body's growth, and are involved in cell to cell communication, control metabolic activity, sleep-wake homeostasis, and altered regulation or dysregulation of adaptive response in various physiologic and pathophysiologic states. (medscape.com)
  • Information of cell-cell communication within the kidney was obtained using receptor-ligand pairing resources. (bvsalud.org)
  • Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone. (nih.gov)