Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Insulin Antibodies: Antibodies specific to INSULIN.Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Islets of Langerhans: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Social Control, Informal: Those forms of control which are exerted in less concrete and tangible ways, as through folkways, mores, conventions, and public sentiment.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Postpartum Thyroiditis: Transient autoimmune thyroiditis occurring in the POSTPARTUM PERIOD. It is characterized by the presence of high titers of AUTOANTIBODIES against THYROID PEROXIDASE and THYROGLOBULIN. Clinical signs include the triphasic thyroid hormone pattern: beginning with THYROTOXICOSIS, followed with HYPOTHYROIDISM, then return to euthyroid state by 1 year postpartum.Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Abortion, Spontaneous: Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.Iodide Peroxidase: A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. EC 1.11.1.8.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.Glutamate Decarboxylase: A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.Receptor-Like Protein Tyrosine Phosphatases, Class 8: A subclass of receptor-like protein tryosine phosphatases that contain an extracellular RDGS-adhesion recognition motif and a single cytosolic protein tyrosine phosphate domain.Autoimmunity: Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.AxisTeaching Materials: Instructional materials used in teaching.Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.Competitive Behavior: The direct struggle between individuals for environmental necessities or for a common goal.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Myelin Basic Protein: An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)History, 19th Century: Time period from 1801 through 1900 of the common era.History, 18th Century: Time period from 1701 through 1800 of the common era.History, 20th Century: Time period from 1901 through 2000 of the common era.Myelin Sheath: The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.Hepatitis, Autoimmune: A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.Hepatitis B: INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.Hepatitis: INFLAMMATION of the LIVER.Hepatitis C, Chronic: INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.Breast Implants: Implants used to reconstruct and/or cosmetically enhance the female breast. They have an outer shell or envelope of silicone elastomer and are filled with either saline or silicone gel. The outer shell may be either smooth or textured.Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)Silicone Gels: Synthetic organosiloxane gels that are formed from synthetic polymers of silicone oxide with organic sidechains (polydimethylsiloxane) by lengthening the polymer chains. Unlike silicone elastomers, they are not treated with amorphous silica. They are used as fillers in breast implants.Silicones: A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)Breast Implantation: Surgical insertion of an inert sac filled with silicone or other material to augment the female form cosmetically.Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.

Weak autoantibody reactions to antigens other than sperm after vasectomy. (1/9574)

Autoantibody activity against various antigens was measured by indirect immunofluorescence in 97 men about to undergo vasectomy and 170 men who had undergone the operation up to six years earlier. There was a significantly higher prevalence of weakly positive autoantibody reactions among those who had undergone vasectomy. There was, however, no evidence that vasectomy could induce stronger autoantibody reactions such as those associated with autoimmune disease.  (+info)

Anti-heart autoantibodies in ischaemic heart disease patients. (2/9574)

One hundred and ninety-nine ischaemic heart disease (IHD) patients were studied with regard to the prevalence of anti-heart autoantibodies (AHA). The incidence of AHA in IHD patients was 1%: one out of 102 patients who suffered acute myocardial infarction (AMI), one out of seventy-two patients who suffered from acute coronary insufficiency (ACI), and none out of twenty-five patients with other signs and symptoms of IHD, had AHA in their sera. An additional 2% of patients who suffered from AMI developed detectable antibody levels during a follow-up period of 15 days. In comparison,, 53% of patients (eight out of fifteen) who underwent heart surgery and who had no AHA prior to operation, developed these antibodies in their sera during 1-2 weeks following operation.  (+info)

Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. (3/9574)

Patients with pemphigus foliaceus (PF) have blisters on skin, but not mucous membranes, whereas patients with pemphigus vulgaris (PV) develop blisters on mucous membranes and/or skin. PF and PV blisters are due to loss of keratinocyte cell-cell adhesion in the superficial and deep epidermis, respectively. PF autoantibodies are directed against desmoglein (Dsg) 1; PV autoantibodies bind Dsg3 or both Dsg3 and Dsg1. In this study, we test the hypothesis that coexpression of Dsg1 and Dsg3 in keratinocytes protects against pathology due to antibody-induced dysfunction of either one alone. Using passive transfer of pemphigus IgG to normal and DSG3(null) neonatal mice, we show that in the areas of epidermis and mucous membrane that coexpress Dsg1 and Dsg3, antibodies against either desmoglein alone do not cause spontaneous blisters, but antibodies against both do. In areas (such as superficial epidermis of normal mice) where Dsg1 without Dsg3 is expressed, anti-Dsg1 antibodies alone can cause blisters. Thus, the anti-desmoglein antibody profiles in pemphigus sera and the normal tissue distributions of Dsg1 and Dsg3 determine the sites of blister formation. These studies suggest that pemphigus autoantibodies inhibit the adhesive function of desmoglein proteins, and demonstrate that either Dsg1 or Dsg3 alone is sufficient to maintain keratinocyte adhesion.  (+info)

Autoantibodies to gastrin in patients with pernicious anaemia--a novel antibody. (4/9574)

Autoantibodies arise when there is a breakdown in immunological tolerance. Autoantibodies to parietal cells and intrinsic factor are found in autoimmune atrophic gastritis (AAG) and are associated with elevated plasma gastrin. Endogenous gastrin autoantibodies have not been described to date. The aim of this study was to investigate the occurrence of autoantibodies to gastrin. Plasma from 50,000 patients, including more than 2000 with AAG, was tested. Gastrin was measured by radioimmunoassay (RIA) in whole plasma and the presence of autoantibody determined by using a control which omitted assay antibody. The quantity and affinity of gastrin autoantibodies was assessed. Three patients had autoantibodies to gastrin. All three had AAG and pernicious anaemia (PA). The antibodies were of low titre and relatively high affinity. Free circulating plasma gastrin levels were within the normal range, but total gastrin levels were elevated. This is the first description of autoantibodies to endogenous gastrin. The incidence of antibodies to gastrin is low, they are found in association with PA, and they may lead to falsely low measurements of plasma gastrin.  (+info)

Associations of anti-beta2-glycoprotein I autoantibodies with HLA class II alleles in three ethnic groups. (5/9574)

OBJECTIVE: To determine any HLA associations with anti-beta2-glycoprotein I (anti-beta2GPI) antibodies in a large, retrospectively studied, multiethnic group of 262 patients with primary antiphospholipid antibody syndrome (APS), systemic lupus erythematosus (SLE), or another connective tissue disease. METHODS: Anti-beta2GPI antibodies were detected in sera using an enzyme-linked immunosorbent assay. HLA class II alleles (DRB1, DQA1, and DQB1) were determined by DNA oligotyping. RESULTS: The HLA-DQB1*0302 (DQ8) allele, typically carried on HLA-DR4 haplotypes, was associated with anti-beta2GPI when compared with both anti-beta2GPI-negative SLE patients and ethnically matched normal controls, especially in Mexican Americans and, to a lesser extent, in whites. Similarly, when ethnic groups were combined, HLA-DQB1*0302, as well as HLA-DQB1*03 alleles overall (DQB1*0301, *0302, and *0303), were strongly correlated with anti-beta2GPI antibodies. The HLA-DR6 (DR13) haplotype DRB1*1302; DQB1*0604/5 was also significantly increased, primarily in blacks. HLA-DR7 was not significantly increased in any of these 3 ethnic groups, and HLA-DR53 (DRB4*0101) was increased in Mexican Americans only. CONCLUSION: Certain HLA class II haplotypes genetically influence the expression of antibodies to beta2GPI, an important autoimmune response in the APS, but there are variations in HLA associations among different ethnic groups.  (+info)

The inhibition of myeloperoxidase by ceruloplasmin can be reversed by anti-myeloperoxidase antibodies. (6/9574)

BACKGROUND: The purpose of this study was to characterize the recently reported inhibition of myeloperoxidase (MPO) by ceruloplasmin and to determine whether this may be disturbed in the presence of anti-MPO antibodies. METHODS: Specificity of the binding between ceruloplasmin and MPO was confirmed by Western blotting and enzyme-linked immunosorbent assay (ELISA), and the enzymatic activity of MPO was measured in the presence of ceruloplasmin, affinity-purified anti-MPO antibodies, or both. The affinity of the binding between MPO and ceruloplasmin and MPO and the anti-MPO antibodies was measured using a biosensor, with the results confirmed by chaotrope ELISA. RESULTS: Affinity-purified anti-MPO antibodies from patients with microscopic polyangiitis and florid renal vasculitis inhibited the binding between ceruloplasmin and MPO to a maximum of 72.9 +/- 12.8%, whereas those from patients with Wegener's granulomatosis and only minimal renal involvement inhibited the binding to a maximum of only 36.8 +/- 10.9% (P < 0. 001), with comparable reversal of the ceruloplasmin-mediated inhibition of MPO activity. Measurement of the affinity of the interactions demonstrated that binding between MPO and the anti-MPO antibodies is stronger than that between MPO and ceruloplasmin (1.61 x 107 to 1.33 x 108 vs. 7.46 x 106 m-1), indicating that binding to the autoantibody would be favored in vivo. CONCLUSIONS: This study confirms a role for ceruloplasmin as a physiological inhibitor of MPO, and demonstrates how the inhibition may be disrupted in the presence of anti-MPO antibodies. Because a majority (16 of 21) of the antibodies did not themselves inhibit MPO activity, their interference with the inhibition mediated by ceruloplasmin may be brought about by steric hindrance consequent upon the binding of the antibody to a dominant epitope at or near the active site.  (+info)

Goodpasture antigen: expression of the full-length alpha3(IV) chain of collagen IV and localization of epitopes exclusively to the noncollagenous domain. (7/9574)

BACKGROUND: Tissue injury in Goodpasture (GP) syndrome (rapidly progressive glomerular nephritis and pulmonary hemorrhage) is mediated by antibasement membrane antibodies that are targeted to the alpha3(IV) chain of type IV collagen, one of five alpha(IV) chains that occur in the glomerular basement membrane. GP antibodies are known to bind epitopes within the carboxyl terminal noncollagenous domain (NC1) of the alpha3(IV) chain, termed the GP autoantigen. Whether epitopes also exist in the 1400-residue collagenous domain is unknown because studies to date have focused solely on the NC1 domain. A knowledge of GP epitopes is important for the understanding of the etiology and pathogenesis of the disease and for the development of therapeutic strategies. METHODS: A cDNA construct was prepared for the full-length human alpha3(IV) chain. The construct was stably transfected into human embryonic kidney 293 cells. The purified full-length r-alpha3(IV) chain was characterized by electrophoresis and electron microscopy. The capacity of this chain for binding of GP antibodies from five patients was compared with that of the human r-alpha3(IV)NC1 domain by competitive enzyme-linked immunosorbent assay. RESULTS: The r-alpha3(IV) chain was secreted from 293 cells as a single polypeptide chain that did not spontaneously undergo assembly into a triple-helical molecule. An analysis of GP-antibody binding to the full-length r-alpha3(IV) chain showed binding exclusively to the globular NC1 domain. CONCLUSION: The full-length human alpha3(IV) chain possesses the capacity to bind GP autoantibodies. The epitope(s) is found exclusively on the nontriple-helical NC1 domain of the alpha3(IV) chain, indicating the presence of specific immunogenic properties. The alpha3(IV) chain alone does not spontaneously undergo assembly into a triple-helical homotrimeric molecule, suggesting that coassembly with either the alpha4(IV) and/or the alpha5(IV) chain may be required for triple-helix formation.  (+info)

Identification of a clinically relevant immunodominant region of collagen IV in Goodpasture disease. (8/9574)

BACKGROUND: The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive glomerulonephritis, with or without lung hemorrhage, whereas autoantibodies specific for the other alpha chains of the heterotrimeric type IV collagen probably do not cause disease. In this study, we have investigated whether differences in fine specificity of autoimmune recognition of the alpha3(IV)NC1 correlate with clinical outcome. METHODS: For mapping of antibody binding to type IV collagen, chimeric collagen constructs were generated in which parts of the alpha3(IV)NC1 domain were replaced by the corresponding sequences of homologous nonreactive alpha1(IV). The different recombinant collagen chimeras allowed the analysis of antibody specificities in 77 sera from well-documented patients. RESULTS: One construct that harbors the aminoterminal third of the alpha3(IV)NC1 was recognized by all sera, indicating that it represents the dominant target of the B-cell response in Goodpasture disease. Seventy percent of the samples recognized other parts of the molecule as well. However, only reactivity to the N-terminus of the alpha3(IV)NC1 correlated with prognosis, that is, kidney survival after six months of follow-up. CONCLUSION: The results indicate the crucial importance of antibody recognition of this particular domain for the pathogenesis of Goodpasture disease, thereby opening new avenues for the development of better diagnostic and therapeutic procedures.  (+info)

*Anti-thyroid autoantibodies

Antithyroid autoantibodies (or simply anti-thyroid antibodies) are autoantibodies targeted against one or more components on ... Anti-Na+/I− symporter antibodies are a more recent discovery of possible thyroid autoantibodies and their role in thyroid ... Saravanan P, Dayan CM (June 2001). "Thyroid autoantibodies". Endocrinol. Metab. Clin. North Am. 30: 315-37, viii. doi:10.1016/ ... Anti-TPO antibodies are the most common anti-thyroid autoantibody, present in approximately 90% of Hashimoto's thyroiditis, 75 ...

*Adrenergic receptor autoantibodies

... autoantibodies to these receptors have been tied to many different heart diseases. Autoantibodies to beta1-adrenergic receptors ... Adrenergic receptor autoantibodies The adrenergic receptors (or adrenoreceptors) are a class of cell membrane-bound protein ... Adrenergic autoantibodies have been linked to Buerger's disease (thromboangiitis obliterans). Buerger's disease is a rare ... "Beta1 autoantibodies trigger conformational changes in the receptor, attenuate receptor internalization. The combination of ...

*Anti-SSA/Ro autoantibodies

... or the combination anti-SSA/Ro or anti Ro/SSA autoantibodies) are anti-nuclear autoantibodies that are associated with many ... Anti-SSA autoantibodies (Anti-Sjögren's-syndrome-related antigen A, also called anti-Ro, ... 2007). "Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in ...

*Autoantibody

The role of autoantibodies in normal immune function is also a subject of scientific research. The causes of autoantibody ... Those who have more than one autoimmune disorder may have several detectable autoantibodies. Whether a particular autoantibody ... the autoantibodies may develop. Systemic autoantibody tests are used to: Help diagnose systemic autoimmune disorders. Help ... leading to production of pathological autoantibodies. These autoantibodies attack the body's own healthy cells, tissues, and/or ...

*P-ANCA

Yehuda Shoenfeld; M. Eric Gershwin; Pier-Luigi Meroni (2007). Autoantibodies. Elsevier. pp. 98-. ISBN 978-0-444-52763-9. ...

*Yehuda Shoenfeld

Natural Autoantibodies : Their Physiological Role and Regulatory Significance cover Natural Autoantibodies : Their ... Autoantibodies. by Yehuda Shoenfeld (Editor), J.B. Peter (Editor). 1996. The Antiphospholipid Syndrome. by Ricard Cervera ( ...

*RAS-associated autoimmune leukoproliferative disorder

Autoantibodies are also common. Investigators at the National Institute of Allergy and Infectious Diseases at the US National ...

*Anti-nuclear antibody

This is the highest dilution of the serum at which autoantibodies are still detectable. Positive autoantibody titres at a ... Category:Chemical pathology Autoantibodies Haserick, John R., Lena A. Lewis, and Donald W. Bortz. "Blood factor in acute ... Autoantibody screening is useful in the diagnosis of autoimmune disorders and monitoring levels helps to predict the ... In case no defined autoantibody can be detected (e.g. anti-ENA antibodies), the testing of anti-DFS70 antibodies is recommended ...

*CD38

Mallone R, Perin PC (2006). "Anti-CD38 autoantibodies in type? diabetes". Diabetes Metab. Res. Rev. 22 (4): 284-94. doi:10.1002 ...

*CD74

See Milatuzumab#CD74 Autoantibodies against CD74 have been identified as a promissing biomarkers in the early diagnosis of the ... "Autoantibodies against CD74 in spondyloarthritis". Annals of the Rheumatic Diseases. 73 (6): 1211-14. doi:10.1136/annrheumdis- ...

*Reference ranges for blood tests

Autoantibodies are usually absent or very low, so instead of being given in standard reference ranges, the values usually ... Autoantibodies associated with rheumatic diseases > Reference ranges Retrieved on April 29, 2010 Rajkumar SV, Kyle RA, Therneau ...

*Anti-citrullinated protein antibody

The presence of autoantibodies against citrullinated proteins in rheumatoid arthritis patients was first described in the mid- ... chronolab.com > Autoantibodies associated with rheumatic diseases > Reference ranges Retrieved on 29 April 2010. ... Subsequent studies demonstrated that autoantibodies from RA patients react with a series of different citrullinated antigens, ... Anti-citrullinated protein antibodies (ACPAs) are autoantibodies (antibodies to an individual's own proteins) that are directed ...

*Anti-histone antibodies

Muller, Sylviane (2014). Chapter 23 - Histone Autoantibodies, In Autoantibodies (Third ed.). San Diego, CA. p. 195. ISBN ... Anti-histone antibodies are autoantibodies that are a subset of the anti-nuclear antibody family. They are found in 50%-70% of ... chronolab.com > Autoantibodies associated with rheumatic diseases > Reference ranges Retrieved on April 29, 2010. ...

*Anti-dsDNA antibodies

This effect can also occur after an infection causes the production of autoantibodies to other structures within the nucleus. ... Subsequently, in 1957, antibodies to dsDNA were the first autoantibodies to be identified in patients with SLE. Although the ... Hueber W, Utz PJ, Steinman L, Robinson WH (2002). "Autoantibody profiling for the study and treatment of autoimmune disease". ... Automated analysis of the well fluorescence allows for rapid detection of autoantibodies. Microarrays are a newly emerging ...

*Myelin oligodendrocyte glycoprotein

Reindl M, Di Pauli F, Rostásy K, Berger T (August 2013). "The spectrum of MOG autoantibody-associated demyelinating diseases". ... "A single Ig-domain is exposed to the extracellular space" and consequently allows autoantibodies easy access. and therefore ... 2015). "Spectrum of MOG Autoantibody-Associated Inflammatory Diseases in Pediatric Patients". Neurology. 84 (14): Supplement I4 ... and it has been found to be associated with anti-MOG autoantibodies The anti-mog spectrum in children is equally variated: Out ...

*Anti-nRNP

They are autoantibodies against some ribonucleoproteins. One form of Anti-nRNP is antibodies towards snRNP70 (then called anti- ... "Human anti-nuclear ribonucleoprotein antigen autoimmune sera contain a novel subset of autoantibodies that stabilizes the ...

*Pemphigus

Desmoglein 1, the protein that is destroyed by the autoantibody, is found in only the top dry layer of the skin. PF is ... When autoantibodies attack desmogleins, the cells become separated from each other and the epidermis becomes "unglued", a ... The name is derived from the Greek root "pemphix" meaning "pustule". In pemphigus, autoantibodies form against desmoglein. ... autoantibodies reacting against epithelial adhesion molecules. Pemphigus is further divided in two major subtypes: pemphigus ...

*Paolo Casali

They also blunt autoantibody responses in lupus-prone mice, thereby alleviating lupus immunopathology and outline an important ... Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain CDR3 Arg in binding of dsDNA and ... Small molecule inhibitor of Rab7 impairs B cell class-class switching and plasma cell survival to dampen the autoantibody ... Nature and functions of autoantibodies. Nature Rev. Rheum. 4:491-498. PMID 18756274; PMCID: PMC2703183. Xu, Z., S. Pal, H. Zan ...

*Myenteric plexus

"Autoantibodies to Auerbach's plexus in achalasia". Cellular and molecular biology (Noisy-le-Grand, France). 41 (8): 1033-8. ...

*Lupus nephritis

Autoantibodies direct themselves against nuclear elements. The characteristics of nephritogenic autoantibodies ( lupus ... autoantibodies of certain isotypes activate complement. The diagnosis of lupus nephritis depends on blood tests, urinalysis, X- ... nephritis) are: antigen specificity directed at nucleosome, high affinity autoantibodies form intravascular immune complexes, ...

*Immunologic adjuvant

2003). "Induction of lupus autoantibodies by adjuvants". J Autoimmun. 21 (1): 1-9. doi:10.1016/S0896-8411(03)00083-0. PMID ...

*Autoimmune encephalitis

Solimena, M (1988). "Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I ... Hart, IK (1997). "Autoantibodies detected to expressed K+ channels are implicated in neuromyotonia". Ann. Neurol. 41 (2): 238- ... Shillito, P (1995). "Acquired neuromyotonia: evidence for autoantibodies directed against K+ channels of peripheral nerve". Ann ... Vincent, Angela; Bien, Christian G. (2005-09-01). "Temporal lobe seizures, amnesia and autoantibodies - identifying a ...

*Causes of schizophrenia

The relevance of some auto-antibodies that act against the NMDAR and VGKC is being studied. Current estimates suggest that ... "Disease-relevant autoantibodies in first episode schizophrenia". Journal of Neurology. 258 (4): 686-688. doi:10.1007/s00415-010 ...

*Chorea gravidarum

Archelos, Juan J.; Hartung, Hans-Peter (2000). "Pathogenetic role of autoantibodies in neurological diseases". Trends in ...

*Aquaporin 4

Aquaporin-4 is the predominant autoimmune target in neuromyelitis optica, or NMO, since a specific AQP4 IgG autoantibody, or ... Pittock SJ, Lennon VA (May 2008). "Aquaporin-4 autoantibodies in a paraneoplastic context". Archives of Neurology. 65 (5): 629- ...
OBJECTIVE As data on the predictive characteristics of diabetes-associated autoantibodies for type 1 diabetes in the general population are scarce, we assessed the predictive performance of islet cell autoantibodies (ICAs) in combination with autoantibodies against insulin (IAAs), autoantibodies against GAD, and/or islet antigen 2 for type 1 diabetes in children with HLA-defined disease predisposition recruited from the general population.. RESEARCH DESIGN AND METHODS We observed 7,410 children from birth (median 9.2 years) for β-cell autoimmunity and diabetes. If a child developed ICA positivity or diabetes, the three other antibodies were measured in all samples available from that individual. Persistent autoantibody positivity was defined as continued positivity in at least two sequential samples including the last available sample.. RESULTS Pre-diabetic ICA positivity was observed in 1,173 subjects (15.8%), 155 of whom developed type 1 diabetes. With ICA screening, 86% of 180 progressors ...
ANAs have been known to be present in BC sera for several decades [25] but their significance remains unknown [24]. This is likely because autoantibodies are part of the normal immune response, and sera from healthy subjects exhibit a plethora of autoantibodies not related to cancer [30-32]. The application of genomics and proteomics to biomarker discovery allowed the identification of multiple autoantibodies in BC sera recognizing TAAs [3-10]. These studies strongly suggested the possibility that autoantibodies in cancer sera were potentially useful biomarkers for the early diagnosis of BC. The seminal work establishing the role of autoantibodies as diagnostic biomarkers in the rheumatic ADs [16-20] suggested the hypothesis that the model epitomized by the rheumatic ADs is highly relevant to explain the plethora of autoantibodies detected in cancer sera. Importantly, PBC as an organ-specific autoimmune disease is characterized by a set of autoantibodies with mitochondrial specificity with ...
TY - JOUR. T1 - Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer. AU - Betteridge, Zoe E. AU - Priest, Lynsey. AU - Cooper, Robert G. AU - McHugh, Neil J. AU - Blackhall, Fiona. AU - Lamb, Janine A. PY - 2018/8/9. Y1 - 2018/8/9. N2 - BACKGROUND: The close temporal association between onset of some connective tissue diseases and cancer suggests a paraneoplastic association. Adult patients with scleroderma with anti-RNA polymerase III autoantibodies and adult patients with dermatomyositis with anti-transcriptional intermediary factor 1 (anti-TIF1) or anti-nuclear matrix protein 2 (anti-NXP2) autoantibodies have a significantly increased risk of developing cancer. Autoantibodies may serve as biomarkers for early detection of cancer and also could be relevant for prediction of responses to immune therapies. We aimed to test whether myositis and scleroderma specific or associated autoantibodies are detectable in individuals with lung cancer.METHODS: Serum ...
Abstract OBJECTIVE/HYPOTHESIS: The aim of this prospective study is to evaluate the possible association between Ménières disease (MD) and autoantibodies. METHODS: Fifty-five patients with definite MD (51 unilateral and 4 bilateral) were matched with 55 patients with unilateral vestibular paresis without cochlear involvement and 55 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, anti-TSH receptor antibody, antithyroperoxidase antibody, antithyroglobulin antibody and of antibodies to non-organ-specific antigens, namely antinuclear antibodies, antibodies to extractable nuclear antigens and antineutrophilic cytoplasmic antibodies. RESULTS: Thirty-three subjects (60%) of the MD group had 1 or more elevated serum autoantibody levels, both organ and non-organ specific; 16 patients (29.1%) with unilateral vestibular paresis had 1 or more elevated serum autoantibody levels, while 13 healthy subjects ...
Idiotypic cross-reactions were evaluated in 60 polynucleotide-binding monoclonal lupus autoantibodies produced by human-human hybridomas that were derived from seven unrelated patients with SLE. Three antiidiotype reagents were prepared by immunization of rabbits or a mouse with monoclonal autoantibodies from two patients. Binding of the three reagents to their corresponding idiotypes was inhibited by one or more polynucleotides, an indication that the antiidiotypes reacted with the variable regions of the autoantibodies. Each antiidiotype appeared to detect a different idiotypic determinant. Of the 60 monoclonal autoantibodies tested, 40 reacted in one or more competitive immunoassays; 15 reacted with one antiidiotype, 10 reacted with two antiidiotypes and 15 reacted with three antiidiotypes. A monoclonal antiidiotype reagent cross-reacted with autoantibodies from six of the seven patients. The idiotypic cross-reactions of immunoglobulins from unrelated patients suggest that the autoantibodies ...
Gerard-Gonzalez A, Gitelman SE, Cheng P, Dubose SN, Miller KM, Olson BA, Redondo MJ, Steck AK, Beck RW. Comparison of autoantibody-positive and autoantibody-negative pediatric participants enrolled in the T1D Exchange clinic registry (1). J Diabetes. , June, 2013; 5(2):216-23 ...
Fibrillarin, a component of the U3 RNP particle, is a target for the spontaneously arising autoantibodies in human scleroderma and a monoclonal autoantibody (72B9) derived from the autoimmune mouse strain (NZB x NZW) F1. Autoantibodies against fibrillarin can also be induced in H-2s mice by treatment with mercuric chloride (HgCl2). The objective of this study was to compare the spontaneously occurring anti-fibrillarin autoantibody response with the autoantibody response induced by HgCl2 treatment. Immunofluorescence microscopy on human HEp2, mouse 3T3, and Xenopus XIK-2 cells, immunoblotting with use of nuclear extract from human MOLT-4, mouse 3T3, and Xenopus XIK-2 cells, and immunoprecipitation with use of in vitro translation products of RNA transcripts from yeast fibrillarin cDNA were used in this analysis. Both spontaneous and induced autoantibodies displayed common reactivity in that, irrespective of the antigenic source, they gave the same nucleolar immunofluorescence pattern and a ...
TY - JOUR. T1 - A Novel Autoantibody to Plasminogen and Its Characterization in Heymann Nephritis. AU - Makker, Sudesh P. PY - 1994/7. Y1 - 1994/7. N2 - Heymann nephritis (HN) of rat is an experimental model of human membranous glomerulonephropathy (MGN). It is generally accepted that the glomerular lesion of HN results from the binding of antibodies (autoantibodies in active HN and heterologous antibodies in passive HN) to gp330, a receptor of the low-density lipoprotein receptor superfamily located on the glomerular epithelial cell. We have previously shown that plasminogen (plg) is a ligand for gp330. This report shows that in addition to antibodies to receptor, gp330, novel autoantibodies (Aab) to ligand, plg, also develop in the course of HN and accumulate selectively and in parallel with gp330 antibodies in the glomeruli of both active and passive HN. Aab to plg are present in serum and in immunoglobulin G (IgG) eluted from glomeruli of diseased animals with the concentration severalfold ...
Early studies primarily of first-degree relatives followed over time demonstrate that islet cell autoantibodies may predict type 1 diabetes (13). After the development of robust autoantibody assays that are high capacity, precise, and reproducible, considerable data have accumulated to demonstrate that autoantigen-specific antibodies predict type 1 diabetes (14,15). The quest to identify one type of autoantibody as a better predictor than another has failed, because no clear order of appearance has been detected. Rather, several studies taken together suggest that the number of autoantibodies is predictive rather than the order of their appearance (16). This is particularly true for young children, since the age (17,18) as well as sex (19) affect the expression of both insulin and IA-2 autoantibodies (rev. in 2). The diagnostic sensitivity of these two autoantibodies decreases with increasing age. While IAAs have their highest diagnostic sensitivity (∼50-60%) below the age of 10 years (15,18), ...
The present study has three important findings. First, one-third of patients with active TB had elevated serum autoantibodies. The prevalences of their autoantibodies, especially anticardiolipin IgG and anti-Scl-70, were significantly higher than those of the general population.10 Second, consistent with previous studies,1-4 the presence of autoantibodies neither altered the clinical manifestations and radiographic findings of active TB nor changed the risk of developing adverse events during anti-TB treatment. Third, the elevated autoantibody levels returned to normal limits simply by anti-TB treatment and not by immunosuppressive therapy. These findings suggest that increased serum autoantibodies during active TB may not be diagnostic of autoimmune diseases. Clinical correlation and follow-up are still necessary.. Autoantibodies come from a break in self-tolerance whereby fragments of mixed self-antigens and pathogen antigens may induce immune response, as in a mode of epitope spread and ...
Abstract: : Purpose:Glaucoma is worldwide one of the leading causes of blindness. There is evidence that an autoimmune mechanism is involved in a subset of glaucoma patients. The aim of this study was to analyze the autoantibody repertoires in sera of glaucoma patients and healthy subjects. Methods:A total of 100 patients were divided into four groups: healthy volunteers without any ocular disorders (n=25), patients with primary open angle glaucoma (POAG, n=25), ocular hypertension (OHT, n=25), and normal tension glaucoma (NTG, n=25). All groups were matched for age and gender. The sera of patients were testest against western blots of retinal antigens. The autoantibody patterns were digitized and subsequently analyzed by multivariate statistical techniques and artificial neural networks. Results:All patients showed different, complex staining patterns of autoantibodies against retinal antigens. The number of peaks was increased in sera of POAG patients compared to all other groups. Including ...
Combinations of beta cell specific autoantibodies at diagnosis of diabetesin young adults reflects different courses of beta cell damage. ...
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Insulin Autoantibodies to insulin (IAA) can predict risk of type-1 diabetes or confirm a diagnosis of type-1 diabetes. IAA are most common in children with or at risk for type-1 diabetes.. GAD, GAD65 Autoantibodies to GAD (GADA), like IAA, are also predictive of risk for type-1 diabetes. GAD autoantibodies are present in the majority of adult patients with autoimmune diabetes.. IA-2 Autoantibodies against IA-2 (IA2-A) are the second most common autoantibody in type-1 diabetes. GAD and IA-2 autoantibodies are the most common in type-2 diabetes that also has an autoimmune component.. For children, the number of autoantibodies present is a better predictor of disease risk than the presence of any single antibody.. ...
TY - JOUR. T1 - Autoantibodies, autoimmunity and cancer (review). AU - Tomer, Yaron. AU - Sherer, Yaniv. AU - Shoenfeld, Yehuda. PY - 1998/5/7. Y1 - 1998/5/7. N2 - There is a strong association between neoplasms and autoimmune diseases. Numerous autoimmune phenomena have been reported in malignancies and conversely: malignant tumors are diagnosed in increasing frequency in autoimmune conditions. We review the most common autoimmune diseases and autoantibodies found in malignancies, discuss the therapeutic role of these autoantibodies in cancer, and summarize the current knowledge on malignant transformation in autoimmunity.. AB - There is a strong association between neoplasms and autoimmune diseases. Numerous autoimmune phenomena have been reported in malignancies and conversely: malignant tumors are diagnosed in increasing frequency in autoimmune conditions. We review the most common autoimmune diseases and autoantibodies found in malignancies, discuss the therapeutic role of these ...
Autoimmune diseases are characterized by the presence of multiple autoantibodies that react with components of nuclear, cytoplasmic, or surface origin (for review see Nakamura and Tan, 1992; Fritzler, 1997). In clinical medicine, autoantibodies have been used to establish diagnosis, estimate prognosis, follow the progression of a specific autoimmune disease, and, finally, increase our knowledge of the pathophysiology of autoimmunity. In cell biology, autoantibodies have been extremely useful as probes for the identification of novel proteins and isolation of their corresponding genes. Human autoimmune sera have been particularly useful in the study of the eukaryotic nucleus where they have identified a wide range of nuclear antigens, including both single- and double-stranded DNA, RNA, histones, small nuclear RNA-binding proteins, transcription factors, nuclear lamins, heterochromatin-associated proteins, topoisomerase I and II, and centromere proteins (Tan, 1989, 1991; Earnshaw and Rattner, ...
Jay M. Sosenko, Jay S. Skyler, Jerry P. Palmer, Jeffrey P. Krischer, Liping Yu, Jeffrey Mahon, Craig A. Beam, David C. Boulware, Lisa Rafkin, Desmond Schatz, George Eisenbarth, the Type 1 Diabetes TrialNet and the Diabetes Prevention Trial-Type 1 Study Groups ...
About 60%-90% of type I (insulin-dependent) diabetics have antibody against islet cell cytoplasmic glycoprotein ("islet cell autoantibody") at the time of diagnosis, and many of those initially without this antibody develop it later. This antibody disappears within 2 years after appearance in 85%-90% of type I diabetics. It has also been reported in about 20% of type II diabetics and about 10% of gestational diabetics at time of diagnosis. About 30%-50% of children have autoantibody against insulin (antiinsulin antibody) at time of diagnosis before beginning insulin therapy and some (much less than formerly) develop it after using therapeutic insulin. Some patients have autoantibodies against beta cell surface antigen (beta cell antibodies). Over 95% of type I patients possess the human lymphocyte antigen (HLA) DR3 or DR4. However, at present these autoantibodies and HLAs are not being widely used in clinical medicine or in diagnosis.. ...
Synonyms for autoantibody in Free Thesaurus. Antonyms for autoantibody. 2 words related to autoantibody: rheumatoid factor, antibody. What are synonyms for autoantibody?
Our private blood test profile for Autoantibody Profile II in London tests for Thyroid peroxidase antibodies, Islet Cell antibodies, Adrenal antibodies and more. It has a guaranteed turnaround time of 3 working days.
We performed a nested case-control analysis within the Finnish Type 1 Diabetes Prediction and Prevention Study birth cohort, carrying HLA-conferred susceptibility to type 1 diabetes (n = 7782). Serum total fatty acid composition was analysed by gas chromatography in 240 infants with islet autoimmunity and 480 control infants at the age of 3 and 6 months. Islet autoimmunity was defined as repeated positivity for islet cell autoantibodies in combination with at least one of three selected autoantibodies. In addition, a subset of 43 infants with primary insulin autoimmunity (i.e. those with insulin autoantibodies as the first autoantibody with no concomitant other autoantibodies) and a control group (n = 86) were analysed. A third endpoint was primary GAD autoimmunity defined as GAD autoantibody appearing as the first antibody without other concomitant autoantibodies (22 infants with GAD autoimmunity; 42 infants in control group). Conditional logistic regression was applied, considering multiple ...
TRAb was measured by a 2° generation method. The Fig. 4 shows the results of TRAb measurements in patients with various newly diagnosed thyroid disorders and in healthy controls. The horizontal dotted line indicates the distinction between the values of TRAb positive and negative (cut-off 1.0 IU / L). It can be seen as patients with Graves disease have almost all of a value above the cut-off while the healthy controls, as well as patients with non-toxic goitre, are all negative TRAb (except one). In patients with autoimmune hypothyroidism, characterized by the presence of thyroglobulin autoantibody (TgAb) and thyroperoxidase autoantibody (TPOAb), there is a low percentage of TRAb (probably type blockers). In summary this study shows an excellent specificity of the method with the ability to discriminate between patients with GD from healthy ones ...
TY - ABST. T1 - OX40 and OX40L are highly associated with Autoantibody Formation in early Rheumatoid Arthritis, and predict Flare after Anti-TNF Discontinuation. AU - Laustsen, Julie Kristine. AU - Rasmussen, Tue Kruse. AU - Stengaard-Pedersen, Kristian. AU - Hetland, Merete Lund. AU - Hørslev-Petersen, Kim. AU - Hvid, Malene. AU - Deleuran, Bent Winding. PY - 2013/6. Y1 - 2013/6. M3 - Conference abstract for conference. ER - ...
Humans and animals with lupus produce autoantibodies that can cause inflammation, as well as damage cells and organs of ones own body. In particular, antibodies to double-stranded DNA contribute to organ damage. Researchers have long investigated the possibility of blocking the actions of lupus-related autoantibodies to reduce the extent of such damage. Typically, such research is first tested in animals to ensure efficacy and safety before being conducted in humans. Researchers at The Feinstein Institute for Medical Research have created a new experimental molecule to test its ability to inhibit lupus-related autoantibody attachment to ds-DNA isolated from mice, as well as to components of kidneys extracted from mice, and to living brain cells of mice. The results of these studies provide hope for the development of more specific, less toxic therapies for lupus. However, more animal research is needed before this molecule can be tested in living humans with lupus ...
Autoantibodies to GAD65 (GAD65Ab) are prominent in type 1 diabetes. These autoantibodies may be present both years before and after the clinical diagnosis of type 1 diabetes and are widely used as a marker for the disease. Recently it has been demonstrated that progression to type 1 diabetes is accompanied by GAD65Ab epitope maturation. Here we examine whether autoantibody maturation processes also progress after the clinical diagnosis of type 1 diabetes. Antibody reactivity to GAD65, GAD67 and GAD65/67 fusion proteins was measured by radioimmunoassays in 62 children with type 1 diabetes. Samples were taken at diagnosis and five years later. While the overall GAD65Ab level declined over time, the epitope pattern was remarkably stable with no significant changes in binding pattern. Loss of GAD65Ab-positivity was associated with significantly lower GAD65Ab indices at diagnosis compared to patients sera that remained GAD65Ab-positive. The decrease in GAD65Ab levels did not correlate to ...
Autoimmunization definition, antibody production by an organism in response to and against any of its own tissues, cells, or cell components. See more.
Objective. RA patients develop autoantibodies against a spectrum of antigens but their clinical significance is unclear. Using the phenome-wide association study (PheWAS) approach, we examined the association between autoantibodies and clinical subphenotypes of RA. Methods. This study was conducted using a validated electronic medical record (EMR) RA cohort from 2 tertiary care centers. Using a published multiplex bead assay, we measured 36 autoantibodies targeting epitopes implicated in RA. We extracted all ICD-9 codes for each subject and grouped them using a published method into disease categories (PheWAS codes). We tested for the association of each autoantibody grouped by targeted protein with PheWAS codes. For significant associations (false discovery rate [FDR] ≤0.1), we reviewed 50 medical records of subjects with each PheWAS code to determine the positive predictive value (PPV). Results. We studied 1006 RA subjects, mean age 61.0 years (SD 12.9) and 79.0% female. There were 3,568 ...
Preeclampsia is a serious pathologic complication during pregnancy but its pathogenesis remains unclear. We recently demonstrated that production of auto-antibody against angio-tensin (AGN) II type I receptor (AT1-AA) causes hypertension in experimental animals. Current study determined whether AT1-AA is present in pregnant women and if so, to investigate its potential role in the development of preeclampsia. Blood samples were collected from 35 pregnant women (preeclampsia=18, control=17) and AT1-AA was detected. To determine the potential mechanisms by which AT1-AA may contribute to the development of preeclampsia, vasoconstrictive effects of purified AT1-AA was determined in isolated rat arteriae cerebri media and its pro-apoptotic and cytotoxic effect was determined in cultured HUVEC. Compared with the normal pregnant women (week 37 to 39), sera levels of AT1-AA were markedly increased in preeclamptic patients (0.27±0.03 μmol/L vs. 0.023±0.017 μmol/L, P,0.01). In isolated resistant ...
An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individuals own proteins. Many autoimmune diseases (notably lupus erythematosus) are caused by such autoantibodies. Antibodies are produced by B cells in two ways: (i) randomly, and (ii) in response to a foreign protein or substance within the body. Initially, one B cell produces one specific kind of antibody. In either case, the B cell is allowed to proliferate or is killed off through a process called clonal deletion. Normally, the immune system is able to recognize and ignore the bodys own healthy proteins, cells, and tissues, and to not overreact to non-threatening substances in the environment, such as foods. Sometimes, the immune system ceases to recognize one or more of the bodys normal constituents as "self," leading to production of pathological autoantibodies. These autoantibodies attack the bodys own healthy cells, tissues, and/or organs, causing ...
Methods SeroTag utilizes over 7,000 human proteins as antigen collection in bead-based suspension arrays (Luminex FlexMap 3D) to allow for high throughput serum sample processing with high accuracy, followed by standard and advanced data mining procedures. We screened over 4,000 serum samples from patients with autoimmune diseases such as SLE (n= ,500), SSc (n= ,250), RA (n= ,500), and healthy individuals (n= ,350) to confirm known and to discover novel autoantibodies. Recombinant antigens were covalently coupled to magnetic, color coaded beads and serum samples were incubated with 20 multiplex bead mixes each representing hundreds of antigens. Univariate and multivariate statistical analyses were performed to reveal significant antigens and to define correlation of antigens with clinical parameters and amongst themselves. ...
Acharacteristic of systemic autoimmune diseases is the production of high-titer autoantibodies (autoAbs)1 to a variety of self-constituents (1). These autoAbs are important diagnostic markers of disease, and their patterns are specific for particular autoimmune diseases (1). They are also important because autoAbs can be pathogenic under certain circumstances (2)(3)(4). The pathogenic consequences of activated autoreactive B cells are not limited to autoAb production, as B cells also promote T cell activation (5).. Thus, it has been of great interest to understand the origins of autoreactive B cells in autoimmune animals and, conversely, how they are controlled in normal animals. It is possible that intrinsic B cell defects (6)(7)(8) leading to B cell hyperactivity (9)(10) account for the production of autoAbs. In this view, autoAbs are the result of nonspecific B cell activation. On the other hand, an early clue to an important role of autoantigen (autoAg) in the genesis of such B cells in ...
The present study analyzed the clinical, radiographic, and immunologic features of a series of 71 RA patients along a 9-year interval. As a group, there was progressive deterioration in functional capacity and in joint structure. The serum levels of APF and anti-CCP antibodies tended to remain stable while serum levels of rheumatoid factor increased along the 9-year interval. There was no consistent association of autoantibody status at baseline with rate of joint destruction along the 9-year interval. The outcome measure for evaluation of disease severity was the rate of joint destruction as measured by the progression in Sharp index. Therefore, we calculated the difference in Sharp index between the end and the beginning of the study for each patient and tested the correlation of this parameter with the autoantibody status at the beginning of the study. No statistically significant correlation between the baseline autoantibody status and the rate of joint destruction was observed. When a ...
The current study, led by PD Dr. Harald Prüss of Charités Department of Neurology with Experimental Neurology on Campus Charité Mitte and the DZNEs Berlin site, focused on an autoantibody that targets a specific protein on the surface of brain cells. This molecule, known as NMDA receptor, is essential for the interconnection of neurons and normal brain development. "The NMDA receptor antibody is a relatively common autoantibody. Data from blood donations suggest that up to one percent of the general population may carry this particular autoantibody in their blood. The reasons for this are largely unclear," notes PD Dr. Prüss. If this autoantibody reaches the brain, serious inflammations can arise. However, most carriers are free of such symptoms because the blood-brain barrier - a filtering tissue that surrounds the brains blood vessels - is usually hardly penetrable for antibodies. Unless this barrier is damaged or, as with an embryo in early pregnancy, not yet fully developed ...
Results miRNA profiling revealed 10 miRNAs to be differentially expressed between the groups; 2 in pSS vs HC, 7 in nSS vs HC and 1 in both pSS and nSS vs HC. One miRNA was excluded from further analysis after technical validation by single TaqMan microRNA Assay. The other 9 miRNAs were measured in the validation cohort. Surprisingly, 2 miRNAs were validated to be increased in the nSS group as compared to HC (snRNA-U6 and miR-661). Using the data from both cohorts combined, the levels of snRNA-U6 and miR-661 was associated with serum Ig and C4 in the nSS group, but also in the pSS group. This prompted us to investigate miRNA expression in subgroups of pSS patients. snRNA-U6 and miR-661 levels are significantly increased compared to HC in pSS patients negative for autoantibodies. In autoantibody positive pSS patients, levels of snRNA-U6 and miR-661 are comparable to those found in HC and both miRNAs are significantly increased in autoantibody negative patients as compared to autoantibody positive ...
phdthesis{a3c3a368-ef87-45b1-b612-22823f11b3ea, abstract = {Type 1 diabetes is one of the most common chronic diseases in childhood and adolescence with an increasing incidence worldwide. It is an autoimmune disease with many autoimmune markers, where the zinc transporter 8 autoantibody (ZnT8A) is the most recent autoantibody discovered. The most important genetic susceptibility towards type 1 diabetes is found within the HLA-region on chromosome 6. We showed that all three ZnT8A are common among children and adolescents at type 1 diabetes diagnosis and that 3.4% of the children in Sweden displayed only ZnT8A at diagnosis. Only 7% of the Swedish children were autoantibody negative at diagnosis. Additionally, 0.3% of type 1 diabetes patients in Sweden had an isolated positivity for the islet cell cytoplasm autoantibodies (ICA). This is an autoantibody with an unspecified reaction pattern to most of the other antigens involved in autoantibody formation in type 1 diabetes. The fact that children ...
TY - JOUR. T1 - A possible new bridge between innate and adaptive immunity. T2 - Are the anti-mitochondrial citrate synthase autoantibodies components of the natural antibody network?. AU - Czömpöly, T.. AU - Olasz, Katalin. AU - Simon, Diána. AU - Nyárády, Zoltán. AU - Pálinkás, L.. AU - Czirják, L.. AU - Berki, T.. AU - Németh, P.. PY - 2006/4. Y1 - 2006/4. N2 - Natural antibody (nAb) producing B-1 B cells are considered an intermediate stage of evolution between innate and adaptive immunity. nAbs are immunoglobulins that are produced without antigen priming. nAbs can recognize foreign targets and may serve in the first line of immune defense during an infection. Natural autoantibodies (nAAbs) present in the serum of both healthy humans and patients suffering from systemic autoimmune diseases recognize a set of evolutionarily conserved self-structures. Because of their endosymbiotic evolutionary origin, proteins compartmentalized into mitochondria represent an interesting transition ...
Health,...The presence of specific autoantibodies of the immune system is associ...Antibodies are the defense molecules of the bodys immune system again... First Encouraging Results after Removal of Autoantibodies by Immuno...In earlier studies Marion Bimmler and her research team examined bloo...,Autoantibodies,damage,blood,vessels,in,the,brain,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Breast cancer is the second leading cause of cancer death in women in the United States. While mammography and breast magnetic resonance imaging (MRI) improve detection of early disease, there remains an unmet need for biomarkers for risk stratification, early detection, prediction, and disease prognosis. Sera from patients with breast cancer contain specific autoantibodies (AAb) to tumor antigens that develop as part of the natural immune response to cancer-associated changes in protein structure and expression. The recent development of proteomic tools for AAb detection, including protein microarrays, reverse-phase protein immunoblots, and phage display have identified a number of potential AAb biomarkers for clinical development. Immune response signatures have been identified that are highly specific, but with variable sensitivities for cancer detection. This review focuses on the detection and application of AAb signatures as biomarkers for breast cancer detection and monitoring.. ...
The stochastic and heterogeneous nature of Systemic Lupus Erythematosus (SLE) supports a model whereby multiple genetic and/or environmental hits culminate in loss of tolerance and autoantibody production. Consistent with this model, the phenotype of CD45E613R mice that contain a single point mutation in the juxtamembrane wedge of CD45 depends on genetic context. Despite similar dysregulated phosphatase activity in all immune cells, CD45E613R mice on a C57Bl/6 (B6) background have no overt phenotype while BALB/c (BA) mice develop anti-double stranded (ds) DNA antibodies. An unbiased genome-wide screen for modifiers of autoantibody production between CD45E613R B6 and BA mice identified two candidate loci: Wedge Associated Modifier (Wam) 1 on Chromosome (Chr) 9 encompassing tlr9 and Wam2 on Chr 17 encompassing MHC H2. Previous work has shown that the hyporesponsive BA TLR9 allele permits anti-ds DNA antibodies while the B6 TLR9 allele is resistant. Here, we analyze the contribution of the MHC to ...
Zinc transporter 8 (ZnT8), a protein highly specific to pancreatic insulin-producing beta cells, is vital for the biosynthesis and secretion of insulin. ZnT8 autoantibodies (ZnT8A) are among the most recently discovered and least-characterised islet autoantibodies. In combination with autoantibodies to several other islet antigens, including insulin, ZnT8A help predict risk of future type 1 diabetes. Often, ZnT8A appear later in the pathogenic process leading to type 1 diabetes, suggesting that the antigen is recognised as part of the spreading, rather than the initial, autoimmune response. The development of autoantibodies to different forms of ZnT8 depends on the genotype of an individual for a polymorphic ZnT8 residue. This genetic variant is associated with susceptibility to type 2 but not type 1 diabetes. Levels of ZnT8A often fall rapidly after diagnosis while other islet autoantibodies can persist for many years. In this review, we consider the contribution made by ZnT8 to our ...
Autoreactive B cells are associated with the development of several autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The low frequency of these cells represents a major barrier to their analysis. Antigen (Ag)-tetramers prepared from linear epitopes represent a promising strategy for the identification of small subsets of antigen-reactive immune cells. This is challenging given the requirement for identification and validation of linear epitopes and the complexity of autoantibody responses, including the broad spectrum of autoantibody specificities and the contribution of isotype to pathogenicity. We therefore tested a two-tiered peptide microarray approach, coupled with epitope mapping of known autoantigens, to identify and characterize autoepitopes using the BXD2 autoimmune mouse model. Microarray results were verified through comparison with established age-associated profiles of autoantigen specificities and autoantibody class switching in BXD2 ...
Wilson, J; Warner, N; and Holmes, M, "Autoantibody-secreting plaque forming cells in spleen and thymus of nzb and normal mice." (1971). Subject Strain Bibliography 1971. 1004 ...
This private blood test profile for Autoantibody Profile in London tests for Thyroid Peroxidase antibodies, Antinuclear antibodies, Mitochondrial antibodies and more. This test has a guaranteed turnaround time of 3 working days.
We demonstrate that there are genetic components that contribute to the risk of T1D and, at the same time, contribute to the development of autoantibodies associated with immune-mediated diseases. These shared genetic factors are replicated from the previous GWAS of autoantibody positivity in European subjects, such as the association for IA-2A with SNPs in the IL27 and IFIH1 loci; the association of TPOA with SNPs in the PTPN22, BACH2 and SH2B3 loci; and the association of PCA with SNPs in the IFIH1 locus (6). At the same time, our results do not replicate other loci reported in the GWAS, yet they suggest novel loci that could contribute to autoantibody positivity and therefore should be investigated in independent populations.. Five non-MHC T1D risk loci (IFIH1, PTPN22, SH2B3, BACH2, and CTLA4) contained SNPs that were consistently and robustly associated with positivity for more than one autoantibody. These loci are known to confer risk of several autoimmune disorders, in varying degrees, ...
Human autoantibodies specific to either FcεRIα or IgE have been ascribed a central role in up to 30% of CU cases (50). Our former data suggested that cross-linking anti-FcεRIα Abs are also present in healthy individuals (11). We have now cloned and characterized an IgM Ab from a representative human natural Ab repertoire. This anti-FcεRIα Ab, CBMα8, is remarkable, because it originates from human umbilical cord blood and is entirely in germline configuration. The human anti-FcεRIα Abs previously isolated by phage display (from tonsils of children and peripheral blood of CU patients) differ from CBMα8 by several mutations in the L chains and have totally different CDR3s of the H chains. Nevertheless, the germline Ab CBMα8, like the previous Abs, interfered with the binding of IgE to FcεRIα. By means of an IAsys inhibition assay, we have also shown that IVIg, the IgG fraction from plasma of multiple healthy donors (51), contains the epitope specificity of the natural mAb CBMα8. ...
The KRONUS® 3-Screen Islet Cell Autoantibody ELISA Assay Kit is for the simultaneous and non-differential detection of GAD and/or IA-2 and/or ZnT8 autoantibodies in human serum. The Kit depends upon the ability of the autoantibodies to act divalently and form a bridge between the antigens coated on the ELISA plate wells and the 3-screen biotin. Once this bridge is formed, streptavidin peroxidase attached to the colorogenic substrate (TMB) is bound. The 3-screen biotin and absorbance of each well is directly proportional to the amount of autoantibody present. †For Research Use Only. Not for Use in Diagnostic Procedures.. Manufactured Under Assigned Patents and Licenses. ...
The KRONUS® 3-Screen Islet Cell Autoantibody ELISA Assay Kit is for the simultaneous and non-differential detection of GAD and/or IA-2 and/or ZnT8 autoantibodies in human serum. The Kit depends upon the ability of the autoantibodies to act divalently and form a bridge between the antigens coated on the ELISA plate wells and the 3-screen biotin. Once this bridge is formed, streptavidin peroxidase attached to the colorogenic substrate (TMB) is bound. The 3-screen biotin and absorbance of each well is directly proportional to the amount of autoantibody present. †For Research Use Only. Not for Use in Diagnostic Procedures.. Manufactured Under Assigned Patents and Licenses. ...
Learn about testing for islet autoantibodies, used to identify people at increased risk for developing type 1 diabetes or requiring insulin treatment
From autoantibody research to standardized diagnostic assays in the management of humen diseases : Report on the 12th Dresden Symposium on Autoantibodies September 23-26, ...
Results High expression levels of TLR7 in SLE patients positively correlated with IFN signature and disease activity, but not with BAFF titers. SLE patients with high levels of TLR7 (TLR7hi group) showed an expansion of CD19+CD38highCD24highCD10+ TR B cells. Overall, frequencies of TR B cells positively correlated with the levels of TLR7, but not TLR9. SLE patients, carrying a risk G allele, had increased TLR7 expression and TR cell frequencies, compared to non-risk allele carriers. TLR7hi SLE patients showed increased autoantibody titers and skewing towards Sm/RNP antigens. Upon IFNα priming, TR B cells up-regulated TLR7 and differentiated into plasmablasts in response to TLR7-ligand stimulation. ...
About half of all WAIHA cases will have an autoantibody that reacts with all cells tested, including donor cells. The presence of an IgG autoantibody can be confirmed by elution. Elution is the process by which RBC-bound antibody is removed from the red cells and recovered, being sure that antibody reactivity is maintained so that antibody specificity can be determined. The eluate is usually reactive with all cells tested. Most IgG autoantibodies have an Rh-like specificity, such as anti-e. In order to identify the specific antibody, the laboratory would need to have a supply of rare cells such as Rhnull and D-- cells. Other specificities include those to high incidence antigens or a null phenotype. Examples include autoanti-U, autoanti-Wrb, autoanti-Ena, autoanti-Kpb, and autoanti-Vel ...
autoantibody: Harmful antibody that attacks components of the body called self antigens. Normally autoantibodies are routinely eliminated by the immune systems self-regulatory process-probably...
Objective: After detection of immunological abnormalities in dilated cardiomyopathy (DCM), including autoimmune reactivity against myocytes, attention has been focused on autoimmune mechanisms as potential key elements in DCM pathogenesis. DCM often appeared related to elevated autoantibody (AAB) levels against cardiac proteins including β1-adrenoreceptors. IgG reduction by unselective immunoadsorption (IA) i.e. extracorporeal IgG adsorption to levels at which β1-AABs become nearly undetectable, can be an efficient treatment. Nevertheless, there is controversy on whether β1-AAB removal by IA is indeed the major cause for cardiac improvement. We compared the results of unspecific IA and selective β1-AAB removal.. Methods: In 8/2000-1/2005 DCM patients with LVEF ≤ 30%; and evidence of serum β1-AABs underwent random selection for either unspecific or specific IA which was performed on 5 consecutive days with daily β1-AAB measurements. For unspecific (unselective) IA we used columns ...
TY - JOUR. T1 - Autoantibodies to tumor-associated antigens combined with abnormal alpha-fetoprotein enhance immunodiagnosis of hepatocellular carcinoma. AU - Chen, Yao. AU - Zhou, Yusen. AU - Qiu, Suimin. AU - Wang, Kaijuan. AU - Liu, Siwei. AU - Peng, Xuan Xian. AU - Li, Junfeng. AU - Tan, Eng M.. AU - Zhang, Jian Ying. PY - 2010/3/1. Y1 - 2010/3/1. N2 - The identification and characterization of tumor-associated antigens (TAAs) and their use in antigen mini-arrays for cancer immunodiagnosis has been of interest recently as an approach to cancer detection. In this study, autoantibodies in sera from a patient with HCC were used as probes to immunoscreen a HepG2 cDNA expression library for the identification of TAAs involved in malignant liver transformation. Recombinant proteins from two genes identified in this manner, Sui1 and RalA were expressed, purified and used as antigens in immunoassays to detect the presence of antibodies in sera from 77 patients with HCC, 30 with chronic hepatitis ...
TY - JOUR. T1 - Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS). T2 - BMC Cancer. AU - Sullivan, F. M.. AU - Farmer, Eoghan. AU - Mair, Frances S.. AU - Treweek, Shaun. AU - Kendrick, Denise. AU - Jackson, Cathy. AU - Robertson, Chris. AU - Briggs, Andrew. AU - McCowan, Colin. AU - Bedford, Laura. AU - Young, Ben. AU - Vedhara, Kavita. AU - Gallant, Stephanie. AU - Littleford, Roberta. AU - Robertson, John. AU - Sewell, Herb. AU - Dorward, Alistair. AU - Sarvesvaran, Joseph. AU - Schembri, Stuart. PY - 2017/3/11. Y1 - 2017/3/11. N2 - BACKGROUND: Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the earliest stages of the disease which may allow tumour detection at an earlier stage thus altering prognosis. The primary research ...
Link to publication The Helmholtz Zentrum München, the German Research Center for Environmental Health, pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München has about 1,900 staff members and is headquartered in Neuherberg in the north of Munich. It is a member of the Helmholtz Association, a community of 17 scientific-technical and medical-biological research centers with a total of about 31,000 staff members. www.helmholtz-muenchen.de The main research area of the Institute for Diabetes Research (IDF1) is the pathogenesis and prevention of type 1 diabetes and gestational diabetes. Researchers examine the mechanisms that are responsible for the initiation and progression of these diseases and explore the gene-environment interactions that lead to the development of ...
Encephalitic syndromes are a common medical emergency. The importance of early diagnosis and appropriate treatment is paramount. If initial investigations for infectious agents prove negative, other diagnoses must be considered promptly. Autoimmune encephalitides are being increasingly recognized as important (and potentially reversible) non-infectious causes of an encephalitic syndrome. We describe four patients with autoimmune encephalitis-3 auto-antibody positive, 1 auto-antibody negative-treated during the last 18 months. A comprehensive review of the literature in this expanding area will be of interest to the infectious diseases, general medical and neurology community.. ...
Autoantibodies targeting extracellular, rather than intracellular, domains of an antigen have a higher probability of being pathogenic by modulating receptor function, which can be studied in vitro and in vivo. However, since epitopes may vary between species, matching epitope targets between human autoantibodies and murine models is important for animal studies. For instance, the majority of patients with anti-MOG antibodies did not recognize conformational intact mMOG [56], whereas epitopes recognized by anti-NMDAR antibodies are similar between the two species [35], or at least share some cross-reactivity as in the case of anti-AQP4 antibodies [62, 134]. Longitudinal studies of autoimmune neurological disorders in humans are necessary to substantiate findings from animal models and determine whether the same mechanisms are relevant to human disease. Based on these results, decisions can be made as to whether the therapies that have proved effective in animal models are translatable to human ...
Several reports have demonstrated this previously unknown link between autoimmune disease and increased susceptibility to infectious diseases. In a study it was found that neutralizing autoantibodies to IFN-y lead to increased risk of mycobacterial infections. Autoantibodies were found to have neutralized IFN-y in whole blood culture and thus prevented production of inflammatory cytokines, TNF-α and IL-12 along with impeding MHC class I upregulation. These things are necessary components of a successful Th1 response to mycobacteria; therefore it was shown that autoantibodies against IFN-y affected the immune systems ability to prevent mycobacteria infection. A few studies on anti-IL-6 autoantibodies indicated that patients with this form of autoantibody lead to increased susceptibility to staphylococcal infection. In one patient it was found that when IL-6 was inhibited, C-reactive protein (CRP) induction was also inhibited, which is a key response factor to staphylococcal infection. It was ...
We had a wonderful meandering conversation about genetics, history and evolution. Everybody was quite excited about canine genetics, the genome has now been sequenced, and the different breeds of dogs have been separated for about 30 generations, each has unique medical problems. SNP linkage between individuals in the strains allows rapid location of the genetic region, and then SNP linkage between strains allows gene identification, as dog haplotypes are quite small. As the conversation turned to evolution against autoimmunity, we were discussing why autoantibody targets are generally evolutionary conserved regions. Olle and myself were saying that immunogenic autoantigens would be selected against where possible, such that only regions with vital function (and thus evolutionarily conserved) would be left as autoantibody targets. This made Chris wonder how much autoimmunity could be altered by evolutionary selection, as it usually occurs after reproductive age. This was quite interesting, ...
A couple of years ago a test, done at the University Hospital in Brussels, showed low level Anti nuclear antibody positive with a speckled pattern...
In a pilot study that included children at high risk for type 1 diabetes, daily high-dose oral insulin, compared with placebo, resulted in an immune response to insulin without hypoglycemia. According to the researchers, the findings that support the need for a phase 3 trial to determine whether oral insulin can prevent islet autoimmunity and diabetes in high-risk children, according to a study in the April 21 issue of JAMA.. A few specific proteins are often the trigger for immune responses that cause autoimmune diseases. This has led to the experimental use of antigen-specific therapies (using a substance to initiate an immune response) to prevent, stabilize, or reverse immune-related diseases, such as allergies and multiple sclerosis.. Type 1 diabetes is an autoimmune disease that can be detected in asymptomatic individuals by the presence of islet autoantibodies that develop in children. Antigen-specific therapy using insulin before the development of autoantibodies may induce protective ...
Researchers have identified three promising biological signals that could help detect ovarian cancer before patients display any symptoms of the disease.
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Analysis of antibody positivity profile.(a): Percentage of positive tests (Mean ±SEM) for each patient group. (b): Unsupervised hierarchical clustering of sero
The present invention relates to methods of diagnosing peripheral neuropathies which comprises the steps of determining the titer of autoantibodies directed toward particular nervous system antigens. It also provides for substantially purified preparations of specific antigens, namely neuroprotein-1, histone H3 (neuroprotein-2), .beta.-tubulin (neuroprotein-3), neuroprotein-4, neuroprotein-5, and NP-9 antigen which may be used in such diagnostic methods.
Barz D, Friedrich S, Schuller A, Rummler S.. Keywords: Antibody against angiotensin II-R1; Donor-specific-antibody; Eluate; Graft survival; Immunoadsorption Abstract. BACKGROUND:. The influence of ATR-1-autoantibodies on antibody mediated rejection (AMR) is still discussed controversially. Here we demonstrate some aspects as to diagnostics, treatment, clinical relevance and graft outcome.. METHODS:. A total of 27 transplant recipients (6 heart, 16 kidney, 3 lung and 2 multi-organ) suffering from AMR and a control group without transplant (8 pre-Tx, 1 pregnancy and 16 autoimmune and haematological diseases) were studied. In total, 290 IA eluates and the corresponding patient serum samples before and after immunoadsorption (IA) were analysed.. RESULTS:. ATR-1-and ETR-auto-antibodies (aAB) were found only in 4.5% of sera previous to IA treatment by using ELISA, but could be detected in 42% of IA eluates. AB with very high titres (,1:8 to 1:256) in the eluate were found more frequently in heart than ...
Click to launch & play an online audio visual presentation by Prof. Cees Kallenberg on Pathogenic mechanisms of autoantibodies, part of a collection of online lectures.
en fr Value of RAGE as a circulating biomarker : from sRAGE to anti-sRAGE autoantibodies Intérêt du RAGE comme biomarqueur circulant : du sRAGE aux autoanticorps anti-sRAGE . . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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Results No anti-D2R antibody-positive patient sera bound to the three extracellular loops, but all patient sera (35/35) targeted the extracellular N-terminus. Overall, patient antibody binding was dependent on two main regions encompassing amino acids 20 to 29, and 23 to 37. Residues 20 to 29 contributed to the majority of binding (77%, 27/35), among which 26% (7/27) sera bound to amino acids R20, P21, and F22, 37% (10/27) patients were dependent on residues at positions 26 and 29, that are different between humans and mice, and 30% (8/27) sera required R20, P21, F22, N23, D26, and A29. Seven patient sera bound to the region 23 to 37 independently of D26 and A29, but most sera exhibited N-glycosylation-independent epitope recognition at N23. Interestingly, no evident segregation of binding pattern according to patient clinical phenotype was observed. ...
The present study tested and confirmed the hypothesis that autoantibodies to aberrant O-glycopeptide epitopes represent a fruitful source of sensitive biomarkers for early detection of cancer. Cancer-associated IgG autoantibodies to several O-glycopeptide epitopes were identified in MUC1, whereas IgG antibodies to peptide epitopes were not detected. The study therefore clearly supports that autoantibody biomarker discovery strategies should include aberrant posttranslational modifications for greatest success. Chemoenzymatic synthesis of cancer-associated O-glycopeptides in combination with a microarray platform was shown to be a feasible strategy for broader analysis of the entire cancer O-glycopeptidome.. Initially, we found an absence of immature nonsialylated MUC1 and MUC16 glycoforms in serum of cancer patients with elevated mucin levels, suggesting that these glycoforms are removed by immune cells or scavenger receptors recognizing immature uncapped glycans. This is in agreement with Varki ...
Tissues donated to JDRF program allow better characterization of islet inflammation in T1D - a key understanding towards stopping the type 1 diabetes disease process.. Seven years ago, JDRF launched the JDRF Network for Pancreatic Organ Donors with Diabetes (nPOD) program to collect and characterize pancreata and related tissues from organ donors with type 1 diabetes (T1D), as well as from those who are autoantibody positive but not insulin dependent. These tissues are then made available to investigators addressing the most fundamental questions related to how T1D develops and progresses. The programs creation grew out of the insight that although ani-mal models for the T1D exist, they differ from the human disease in many key aspects and raised the concern that some data derived from such models may not be applicable to the disease in humans. In fact, even after a century of T1D research we know very little about some of the basics of T1D in people at the cellular level, because of the very ...
Read about how two Parkinsons risk genes produce proteins preventing the immune system from turning on the own body, indicating autoimmune mechanisms.
ANTI-B2GPI AUTO-ANTIBODIES These assays are designed with highly purified, non denatured, fully functional human Beta 2-Glyco-Protein 1 (B2GP1) for coating the solid phase, which is then saturated and stabilized
Blood is the optimal source for the diagnostic screening of large human populations for non-invasive markers. Serum and plasma are easily obtained, and moreover blood circulation facilitates the contact with every body tissue, including representative tumor antigens. However, tumor leakage antigens are probably present at the very low range of concentration in plasma, and they probably suffer from extensive proteolysis in a relatively short period (44). Therefore, the search for tumor-specific antigens in blood is a complicated task. Approaches based on a peptide search ("peptidomics"), such as SELDI, are prone to artifacts due to variability issues and require ultraextensive standardization for every step of the procedure, rendering them unsuitable for routine clinical use.. Antibodies are very stable serum molecules with a long tradition of use in immunoassays, which facilitates their standardization. Autoantibodies present in the serum of patients appear to be a promising alternative for ...
Prognostic markers for systemic sclerosis. The risk of death is directly related to the autoantibody pattern. Other serum markers for organ involvement are ...
ImmunArray, developer of the iCHIP™, a groundbreaking in-vitro auto-antibody profiling platform is pleased to announce the launch of their first commercial diagnostic product, SLE-key™ Rule Out, designed to provide physicians the ability to rule out a diagnosis of SLE (Systemic Lupus Erythematous) with a high degree of certainty. The test was developed and validated on a panel of 200 antigens in a 500 patient clinical study performed in collaboration with leading academic rheumatologists.
We use advanced techniques such as recombinant gene technology to develop the latest standardized, precise, reliable and easy-to-use diagnostic tests. We currently offer autoantibody tests for more than 20 clinical indications in the fully automated El...
Immunoglobulin G anti-endothelial cell antibodies: inducers of endothelial cell apoptosis in pulmonary arterial hypertension? (pages 433-440). S. J. Arends, J. G. M. C. Damoiseaux, A. M. Duijvestijn, L. Debrus-Palmans, M. Vroomen, K. A. Boomars, H.-P. Brunner-La Rocca, C. P. M. Reutelingsperger, J. W. Cohen Tervaert and P. van Paassen. Version of Record online: 24 OCT 2013 , DOI: 10.1111/cei.12166. ...
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What is Lupus?. Lupus is a chronic, autoimmune disease that can damage any part of the body (skin, joints, and/or organs inside the body). In lupus, something goes wrong with your immune system which is the part of the body that fights off viruses, bacteria, and germs. Normally our immune system produces proteins called antibodies that protect the body from these invaders. Autoimmune means your immune system cannot tell the difference between these foreign invaders and your bodys healthy tissues ("auto" means "self") and creates autoantibodies that attack and destroy healthy tissue. These autoantibodies cause inflammation, pain, and damage to various parts of the body ...
When the host s blood is drawn, the antibodies are present; scientists can use that blood to create antiserum to cure the illness in others. Additionally, injecting someone with a weak or dead version of a virus may trigger the slow response production of antibodies that will protect the host against a full-blown attack of that virus. Additional research has lead to the ability to genetically alter mouse antibodies for use in humans. Use of antibodies to prevent, and cure disease by artificial means is called antibody therapy ...
This blood test checks for substances called antibodies. These are made by your body in response to insulin and other chemicals related to insulin. It is used to find out whether you have type 1 or type 2 diabetes.
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The name of one of the corresponding authors is given incorrectly in the published article. "Md. Yusuke Yamauchi" should instead be listed as "Yusuke Yamauchi" as provided in the corrected author list above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.. ...
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The primary focus and content of the submitted abstract must be novel. Submission of the abstract implies that the abstract will not have been published in a scientific or professional publication prior to the presentation at the 13th Dresden Symposium on Autoantibodies. The abstract must be informative, including a statement of the studys specific objectives, methods, summary of the results and concluding statement. ...
Due to the remarkable concordance between the role that TG2 plays in increasing these immunogenic peptides affinity for DQ2, the identity of TG2 as the target of the autoantibody response, and the strong genetic association of DQ2 with disease, research into celiac pathogenesis has largely focused on the adaptive branch of the immune response ...
Objective: To investigate the clinical and laboratory features of patients with liver disease and positive anti-liver/kidney microsomal-1 (anti-LKM-1) antibody, and to provide a reference for clinical diagnosis and differential diagnosis. Methods: The clinical data of patients with positive anti-LKM-1 antibody who were treated in our hospital from 2006 to 2016 were collected, and clinical and laboratory features were analyzed and compared. An analysis was also performed for special cases. Results: The measurement of related autoantibodies was performed for about 100 thousand case-times, and 15 patients were found to have positive anti-LKM-1 antibody ...
Abstract of the article: An autoimmune reaction directed against the cardiac b1-adrenergic receptor (beta1-ADR) leading to the generation of autoantibodies (AA) against this G-coupled receptor has been described in patients with heart failure (HF). Agonist-like beta1-ADR-AA are associated with morbidity in HF patients and even predict mortality. Standardised and valid diagnostic tools to detect beta…. ...
I had bloods done and the EBV IgG was reactive which means evidence of past EBV infection more than 8 weeks ago, the autoantibody screen showed...
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Title: Synthetic Peptides: The Future of Patient Management in Systemic Rheumatic Diseases?. VOLUME: 14 ISSUE: 26. Author(s):Kai Kessenbrock, Reinout Raijmakers, Marvin J. Fritzler and Michael Mahler. Affiliation:Dr. Fooke Laboratorien GmbH,Mainstr.85, 41469 Neuss, Germany.. Keywords:Peptide, autoantibody, SLE, dsDNA, Systemic rheumatic disease. Abstract: Since the first description of self-reactive antibodies in systemic autoimmune rheumatic diseases, many autoantigens have been identified as useful diagnostic biomarkers in clinical immunology. Among the autoantigens, double-stranded desoxoribonucleic acid (dsDNA), the Smith antigen (Sm), topoisomerase-I (topo-I), proliferating cell nuclear antigen (PCNA), and others were described as hallmark targets of systemic autoimmune diseases. The detection of the corresponding autoantibodies can be performed with a variety of immunoassays based on native antigens, recombinant proteins or synthetic peptides. As discussed in this review, synthetic ...
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TY - JOUR. T1 - T cell abnormalities in NZB mice occur independently of autoantibody production. AU - Taurog, J. D.. AU - Raveche, E. S.. AU - Smathers, P. A.. AU - Glimcher, L. H.. AU - Huston, D. P.. AU - Hansen, C. T.. AU - Steinberg, A. D.. PY - 1981/5/15. Y1 - 1981/5/15. N2 - By means of a series of crosses and backcrosses, ZB.CBA/N mice were prepared bearing largely NZB autosomal genes, but having X chromosomes derived only from CBA/N mice. The CBA/N X chromosome carries a gene, xid, that is associated with the lack of a B cell subset necessary for most of the spontaneous autoantibody production by NZB mice. These ZB.CBA/N mice failed to develop autoantibodies to T cells, erythrocytes, or DNA. The availability of mice that were mostly NZB, but which failed to make autoantibodies, especially anti-T cell antibodies, allowed us to study possible T cell regulatory defects in NZB mice in the absence of either antibodies reactive with such T cells or other autoantibodies. We found that such mice ...
We investigated the specificities and characteristics of anti-cytoskeleton antibodies in 13 anti-smooth muscle antibody (ASMA)-positive patients with chronic liver disease C (CLD-C), and compared them with those in 7 ASMA-positive patients with autoimmune hepatitis (AIH), and 6 ASMA-positive patients with chronic liver disease B (CLD-B). Anti-microfilaments (anti-MF) were found not only in 6/7 AIH patients (85.7%), but also in 8/13 CLD-C patients (61.5%) with a relatively high incidence, when compared with 1/6 CLD-B patients (16.7%), while, there was no significant difference in the incidence of anti-intermediate filaments (anti-IMF), especially anti-IMF IgM, among these patient groups. Among the patients with CLD-C, the mean levels of serum gammaglobulin and IgG in the anti-MF-positive patients were 2.46 +/- 1.03 g/dl and 3277 +/- 1089 mg/dl, respectively, which were higher than those in the anti-MF-negative patients (1.60 +/- 0.53 g/dl, 2245 +/- 610 mg/dl) and those in the patients with CLD-B ...
Autoimmune polyendocrine syndrome type 1 (APS-1), also known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy/dysplasia (APECED), autoimmune polyglandular syndrome type 1, Whitaker syndrome, or candidiasis-hypoparathyroidism-Addisons disease syndrome, is a subtype of autoimmune polyendocrine syndrome (autoimmune polyglandular syndrome) in which multiple endocrine glands dysfunction as a result of autoimmunity. It is a genetic disorder inherited in autosomal recessive fashion due to a defect in the AIRE gene (autoimmune regulator), which is located on chromosome 21 and normally confers immune tolerance. Autoimmune polyendocrine syndrome type 1 symptoms and signs include the following: Hypoparathyroidism Hypogonadism Vitiligo Alopecia Malabsorption Anemia Cataract Adrenal hyperplasia Autoimmune polyendocrine syndrome type 1 is a condition caused in an autosomal recessive manner. Furthermore, it is due to a defect in AIRE gene (which helps to make a protein that is called the ...
ANA (Antinuclear Antibody) measurement Anti-cyclic citrullinated peptide antibody level Erythrocyte sedimentation rate measurement Rheumatoid factor measurement Serum C reactive protein level Serum uric acid measurement Medical Tests Analyzer labtest bloodtest What does the test result mean?
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TY - JOUR. T1 - Neonatal pemphigus vulgaris. T2 - IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns. AU - Parlowsky, Thomas. AU - Welzel, Julia. AU - Amagai, Masayuki. AU - Zillikens, Detlef. AU - Wygold, Thorsten. PY - 2003/4/1. Y1 - 2003/4/1. N2 - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.. AB - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy ...
Anti-glomerular basement membrane disease is a rare autoimmune disorder characterized by pulmonary hemorrhage, crescentic glomerulonephritis and the presence of circulating anti-glomerular basement membrane antibodies. The simultaneous occurrence of both anti-glomerular basement membrane disease and membranous nephropathy is rare. A 59-year-old Hispanic man presented with acute onset of nausea and vomiting and was found to have renal insufficiency. Work-up included a kidney biopsy, which revealed anti-glomerular basement membrane disease with underlying membranous nephropathy. He was treated with emergent hemodialysis, intravenous corticosteroids, plasmapheresis, and cyclophosphamide without improvement in his renal function. Simultaneous anti-glomerular basement membrane disease and membranous nephropathy is very rare. There have been 16 previous case reports in the English language literature that have been associated with a high mortality and morbidity, and a very high rate of renal failure resulting
TY - JOUR. T1 - Radiologic manifestations of the systemic autoimmune diseases. AU - Primack, Steven. AU - Muller, N. L.. PY - 1998. Y1 - 1998. N2 - Advances in thoracic imaging during the past two decades, such as CT scans and MR imaging, have enhanced our understanding of the pleuropulmonary abnormalities that develop in the systemic autoimmune diseases. In this article, the thoracic radiologic manifestations of several connective tissue diseases (systemic lupus erythematosus, rheumatoid arthritis, Sjogrens syndrome, polymyositis/dermatomyositis, progressive systemic sclerosis, and anklyosing spondylitis), two granulomatous vasculitides, (Wegeners Granulomatosis and Churg-Strauss syndrome), and antiglomerular basement membrane disease are reviewed.. AB - Advances in thoracic imaging during the past two decades, such as CT scans and MR imaging, have enhanced our understanding of the pleuropulmonary abnormalities that develop in the systemic autoimmune diseases. In this article, the thoracic ...
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Anti-SSA/Ro autoantibodies - WikipediaAnti-SSA/Ro autoantibodies - Wikipedia

... or the combination anti-SSA/Ro or anti Ro/SSA autoantibodies) are anti-nuclear autoantibodies that are associated with many ... Anti-SSA autoantibodies (Anti-Sjögrens-syndrome-related antigen A, also called anti-Ro, ... "Clinical significance of autoantibodies recognizing Sjögrens syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Anti-SSA/Ro_autoantibodies&oldid=842518286" ...
more infohttps://en.wikipedia.org/wiki/Anti-SSA/Ro_autoantibodies

Autoantibodies | LabCorpAutoantibodies | LabCorp

Examples of Autoantibodies. Systemic autoantibodies. The list below includes some of the autoantibody tests that are used to ... What are autoantibodies? What are autoantibodies?. Autoantibodies are antibodies (immune proteins) that mistakenly target and ... Why and when are autoantibody tests performed?. Autoantibody tests are performed, along with x-rays, other imaging scans, and ... have autoantibodies and that the prevalence of the most common type of autoantibody, antinuclear antibody (ANA), is highest ...
more infohttps://www.labcorp.com/help/patient-test-info/autoantibodies

Autoantibodies 3 | LabCorpAutoantibodies 3 | LabCorp

Examples of Autoantibodies. Systemic autoantibodies. The list below includes some of the autoantibody tests that are used to ...
more infohttps://www.labcorp.com/help/patient-test-info/autoantibodies-3

JCI -
BAFF-ling autoantibodiesJCI - BAFF-ling autoantibodies

Cytokine-targeting autoantibodies in disease. Spontaneous autoantibody production is a hallmark of many autoimmune diseases, ... Cytokine-specific autoantibodies modulate disease severity. In addition to causing immunodeficiency, autoantibodies against ... 11). Notably, this approach is not limited to detection of autoantibodies against cytokines. Autoantibodies against growth ... BAFF-ling autoantibodies. Stefanie Sarantopoulos1 and Maureen A. Su2 1Department of Medicine, Division of Hematological ...
more infohttps://www.jci.org/articles/view/73166

Thrombocytopenia with Multiple Autoantibodies | The BMJThrombocytopenia with Multiple Autoantibodies | The BMJ

Thrombocytopenia with Multiple Autoantibodies. Br Med J 1969; 3 doi: https://doi.org/10.1136/bmj.3.5670.596-a (Published 06 ...
more infohttp://www.bmj.com/content/3/5670/596.5

Autoantibodies in Diabetes | DiabetesAutoantibodies in Diabetes | Diabetes

ISLET CELL AUTOANTIBODIES. Autoantibodies are created by the immune system when it fails to distinguish between "self" and " ... Islet cell autoantibodies are strongly associated with the development of type 1 diabetes. The appearance of autoantibodies to ... AUTOANTIBODY EFFECTS ON ANTIGEN PRESENTATION. One potential important role played by autoantibodies in the type 1 diabetes ... George J, Schoenfeld Y: Natural autoantibodies. In Autoantibodies. Peter JB, Shoenfeld Y, Eds. Amsterdam, Elsevier,1996 , p.534 ...
more infohttp://diabetes.diabetesjournals.org/content/54/suppl_2/S52?frame=header

Autoantibodies in Diabetes | DiabetesAutoantibodies in Diabetes | Diabetes

ISLET CELL AUTOANTIBODIES. Autoantibodies are created by the immune system when it fails to distinguish between "self" and " ... Islet cell autoantibodies are strongly associated with the development of type 1 diabetes. The appearance of autoantibodies to ... AUTOANTIBODY EFFECTS ON ANTIGEN PRESENTATION. One potential important role played by autoantibodies in the type 1 diabetes ... George J, Schoenfeld Y: Natural autoantibodies. In Autoantibodies. Peter JB, Shoenfeld Y, Eds. Amsterdam, Elsevier,1996 , p.534 ...
more infohttp://diabetes.diabetesjournals.org/content/54/suppl_2/S52?ijkey=4270658e27710cede22dcec93321140289dce04a&keytype2=tf_ipsecsha

autoantibody | immunity | Britannica.comautoantibody | immunity | Britannica.com

Normally autoantibodies are routinely eliminated by the immune systems self-regulatory process-probably... ... autoantibody: Harmful antibody that attacks components of the body called self antigens. ... Autoantibody, harmful antibody that attacks components of the body called self antigens. Normally autoantibodies are routinely ... Autoantibodies also interfere with the normal functioning of cells. For example, in Graves disease, autoantibodies bind to ...
more infohttps://www.britannica.com/science/autoantibody

Cell penetration by antiphospholipid autoantibodies.  - PubMed - NCBICell penetration by antiphospholipid autoantibodies. - PubMed - NCBI

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
more infohttps://www.ncbi.nlm.nih.gov/pubmed/9465489?dopt=Abstract

Autoantibodies | GreenMedInfo | Keyword | Natural MedicineAutoantibodies | GreenMedInfo | Keyword | Natural Medicine

Additional Keywords : Autoantibodies, Body Mass Index (BMI), Glycosylated Haemoglobin (HbA1c), Hypoglycemia. Problem Substances ...
more infohttp://www.greenmedinfo.com/keyword/autoantibodies

Thyroid autoantibodies, preterm birth, and miscarriage | The BMJThyroid autoantibodies, preterm birth, and miscarriage | The BMJ

Thangaratinam and colleagues assess the association of thyroid autoantibodies with miscarriage and preterm birth in ... Thyroid autoantibodies, preterm birth, and miscarriage. BMJ 2011; 342 doi: https://doi.org/10.1136/bmj.d2260 (Published 09 May ...
more infohttps://www.bmj.com/content/342/bmj.d2260

Islet Autoantibodies in Diabetes | Lab Tests OnlineIslet Autoantibodies in Diabetes | Lab Tests Online

Learn about testing for islet autoantibodies, used to identify people at increased risk for developing type 1 diabetes or ... Islet Cell Cytoplasmic Autoantibodies. ICA. Measures a group of islet cell autoantibodies targeted against a variety of islet ... Insulinoma-Associated-2 Autoantibodies. IA-2A. Tests for autoantibodies directed against beta cell antigens. The presence of IA ... Insulin Autoantibodies. IAA. Autoantibody targeted to insulin; insulin is the only antigen thought to be highly specific for ...
more infohttps://labtestsonline.org/tests/islet-autoantibodies-diabetes

Triggering of thyroid hormone autoantibodies.  - PubMed - NCBITriggering of thyroid hormone autoantibodies. - PubMed - NCBI

Triggering of thyroid hormone autoantibodies.. Benvenga S, Trimarchi F.. Comment on. *Discrepant thyroid function tests in a ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/12519808

Serum Autoantibodies: From Identification to Clinical RelevanceSerum Autoantibodies: From Identification to Clinical Relevance

... Pietro Invernizzi,1 Xavier Bossuyt,2 and Dimitrios P. Bogdanos ... Pietro Invernizzi, Xavier Bossuyt, and Dimitrios P. Bogdanos, "Serum Autoantibodies: From Identification to Clinical Relevance ...
more infohttps://www.hindawi.com/journals/jir/2013/382069/cta/

CiNii Articles - 
 		
			AUTOANTIBODIES IN BRONCHIAL ASTHMACiNii Articles - AUTOANTIBODIES IN BRONCHIAL ASTHMA

気管支喘息と自己抗体 [in Japanese] AUTOANTIBODIES IN BRONCHIAL ASTHMA [in Japanese] * * 藤森 勝也 Fujimori Katsuya ... We studied the difference in the prevalence of autoantibodies between the sera of atopic asthma and non-atopic asthma. The ... may cause some trouble in the impaired lymphocyte surveillance and may be especially liable to develope autoantibodies under ...
more infohttps://ci.nii.ac.jp/naid/110002418343

Protective autoantibodies | HSTalksProtective autoantibodies | HSTalks

Elias Toubi on Protective autoantibodies, part of a collection of online lectures. ... Protective autoantibodies. *Prof. Elias Toubi - Bnai-Zion Medical Center, The Technion-Faculty of Medicine, Israel ... Toubi, E. (2007, October 1). Protective autoantibodies [Video file]. In The Biomedical & Life Sciences Collection, Henry ...
more infohttps://hstalks.com/t/212/protective-autoantibodies/

Primary Sjögrens Syndrome and Autoantibodies | IntechOpenPrimary Sjögren's Syndrome and Autoantibodies | IntechOpen

However, this does not stop an interest in other autoantibodies and the significance of their presence for the course of this ... This chapter outlines the autoantibodies found in pSS and discusses their importance in clinical practice. ... The range of autoantibodies found in pSS is constantly expanding, but their significance is not fully established. At present, ... it is known that overactivity of B-lymphocytes leads to the production of a number of autoantibodies-both markers for pSS (such ...
more infohttps://www.intechopen.com/books/autoantibodies-and-cytokines/primary-sj-gren-s-syndrome-and-autoantibodies

Free USMLE Flashcards about FA autoantibodiesFree USMLE Flashcards about FA autoantibodies

Free flashcards to help memorize facts about FA autoantibodies. Other activities to help include hangman, crossword, word ...
more infohttps://www.studystack.com/flashcard-896970

autoantibody (thing) by BioTech - Everything2.comautoantibody (thing) by BioTech - Everything2.com

autoantibody (thing). See all of autoantibody, no other writeups in this node. ...
more infohttps://everything2.com/user/BioTech/writeups/autoantibody

Islet autoantibodies - definition of islet autoantibodies by The Free DictionaryIslet autoantibodies - definition of islet autoantibodies by The Free Dictionary

islet autoantibodies synonyms, islet autoantibodies pronunciation, islet autoantibodies translation, English dictionary ... definition of islet autoantibodies. abbreviation for 1. Institute of Contemporary Arts 2. International Cooperation ... redirected from islet autoantibodies). Also found in: Medical, Encyclopedia.. Related to islet autoantibodies: GAD antibodies ... The concept of screening for islet autoantibodies is controversial.. Islet autoantibodies and type 1 diabetes: does the ...
more infohttps://www.thefreedictionary.com/islet+autoantibodies

Identifying targets of autoantibodiesIdentifying targets of autoantibodies

The host factors that are targeted by autoantibodies produced by SLE patients ... ... produce autoantibodies that target can cause damage to multiple organ systems. ... The authors identified several autoantibody targets, and determined that SLE patients with high levels of autoantibodies ... Identifying targets of autoantibodies. by Journal of Clinical Investigation Patients with the autoimmune disease systemic lupus ...
more infohttps://medicalxpress.com/news/2013-11-autoantibodies.html

On the profiling of autoantibodies in psychiatric disorders |  KTHOn the profiling of autoantibodies in psychiatric disorders | KTH

Subject area: Biotechnology Doctoral student: David Just , Protein Science Opponent: Professor Angela Vincent, University of Oxford, UK Supervisor: Professor Peter Nilsson, KTH ...
more infohttps://www.kth.se/en/cbh/kalender/on-the-profiling-of-autoantibodies-in-psychiatric-disorders-1.872081?date=2019-02-08&orgdate=2019-01-21&length=1&orglength=0

Pivotal Role Found for IgC Autoantibodies in IgA NephropathyPivotal Role Found for IgC Autoantibodies in IgA Nephropathy

... and the autoantibody levels predict disease progression. Thus, we can measure these autoantibodies in blood to identify ... This leads to development of autoantibodies, mostly of the IgG subclass; 3) The IgG autoantibodies bind galactose-deficient ... Pivotal Role Found for IgC Autoantibodies in IgA Nephropathy. IgA nephropathy is the leading primary glomerulonephritis ... The IgG autoantibody specific for galactose-deficient IgA1was not found in control extracts from two other forms of ...
more infohttps://www.newswise.com/articles/pivotal-role-found-for-igg-autoantibodies-in-iga-nephropathy

Autoantibodies to Myelin Basic Protein In Multiple Sclerosis | SpringerLinkAutoantibodies to Myelin Basic Protein In Multiple Sclerosis | SpringerLink

Warren K.G., Catz I. (1989) Autoantibodies to Myelin Basic Protein In Multiple Sclerosis. In: Kim S.U. (eds) Myelination and ... Catz I, Warren KG: Intrathecal synthesis of autoantibodies to myelin basic protein in multiple sclerosis. Can J Neurol Sci 13: ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4613-0777-8_17

Autoantibodies to Tumor-Associated Antigens in Epithelial Ovarian CarcinomaAutoantibodies to Tumor-Associated Antigens in Epithelial Ovarian Carcinoma

... Benjamin Piura1 and Ettie Piura2 ... L. Zhong, K. Ge, J. C. Zu et al., "Autoantibodies as potential biomarkers for breast cancer," Breast Cancer Research, vol. 10, ... A. Barua, M. J. Bradaric, T. Kebede et al., "Anti-tumor and anti-ovarian autoantibodies in women with ovarian cancer," American ... F. Fernández Madrid, "Autoantibodies in breast cancer sera: candidate biomarkers and reporters of tumorigenesis," Cancer ...
more infohttps://www.hindawi.com/journals/jo/2009/581939/ref/
  • Anti-SSA autoantibodies (Anti-Sjögren's-syndrome-related antigen A, also called anti-Ro , or the combination anti-SSA/Ro or anti Ro/SSA autoantibodies ) are anti-nuclear autoantibodies that are associated with many autoimmune diseases, such as systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous lupus erythematosus (SCLE), neonatal lupus and primary biliary cirrhosis . (wikipedia.org)
  • Patients with the autoimmune disease systemic lupus erythematosus (SLE) produce autoantibodies that target can cause damage to multiple organ systems. (medicalxpress.com)
  • Subsequently, it was demonstrated that many new-onset type 1 diabetic patients had insulin autoantibodies (IAAs), and further analysis of islet autoantigens resulted in the discovery of the insulinoma-antigen 2 (IA-2), which was co-precipitated with GAD65 in many 64K + patient sera. (diabetesjournals.org)
  • However, when the immune system ceases to recognize one or more of the body's normal constituents as "self," it may produce autoantibodies that react with its own cells, tissues, and/or organs. (labcorp.com)
  • Anti-tumor and anti-ovarian autoantibodies in women with ovarian cancer," American Journal of Reproductive Immunology , vol. 57, no. 4, pp. 243-249, 2007. (hindawi.com)
  • 2007). "Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome" . (wikipedia.org)
  • Identification of cytokine-targeted autoantibodies in patients can be informative for diagnosis and predicting clinical outcome. (jci.org)
  • Spontaneous autoantibody production is a hallmark of many autoimmune diseases, and these disease-specific autoantibodies are often useful in affirming a clinical autoimmune diagnosis. (jci.org)
  • It is speculated that progression to β-cell loss and clinical onset of type 1 diabetes is reflected in a developing pattern of epitope-specific autoantibodies. (diabetesjournals.org)
  • This chapter outlines the autoantibodies found in pSS and discusses their importance in clinical practice. (intechopen.com)
  • Study Selection: English-language original articles and critical reviews concerning ZnT8 and the clinical applications of islet autoantibodies in diabetes were reviewed. (thefreedictionary.com)
  • In this issue of the Journal of Clinical Investigation , Jordan Price and colleagues at Stanford University developed a microarray to identify cytokines, chemokines, and other circulating proteins as potential targets of the autoantibodies produced by SLE patients. (medicalxpress.com)
  • There were no clinical features to differentiate these cases from other cases of psychosis in Cameo (Table 1 ), even in retrospect, and the autoantibody positive cases fulfilled criteria for DSM-IV schizophrenia. (springer.com)
  • Although there are few clinical implications resulting from this classification, autoantibody profiles indicate that AIH is a heterogenous group of entities. (omicsonline.org)
  • The authors identified several autoantibody targets, and determined that SLE patients with high levels of autoantibodies directed against the B cell activating factor (BAFF) had more severe SLE-associated symptoms. (medicalxpress.com)
  • In an accompanying commentary, Maureen Su of the University of North Carolina and Stephanie Sarantopoulos of Duke University discuss how identification of autoantibody targets produced by patients with autoimmune disorders will be informative for diagnosis and therapeutic strategy development. (medicalxpress.com)
  • Among the remarkable advances in neurology in the last 2-3 decades has been identification of highly specific autoantibodies and their molecular targets. (aacc.org)
  • Adrenergic receptor autoantibodies The adrenergic receptors (or adrenoreceptors) are a class of cell membrane-bound protein receptors throughout the body that are targets of the catecholamines, especially norepinephrine(or noradrenaline) and epinephrine (or adrenaline). (wikipedia.org)
  • For example, in Graves disease , autoantibodies bind to receptor cells in the thyroid gland, stimulating the overproduction of thyroid hormones. (britannica.com)
  • Samples that are devoid of autoantibodies, and are therefore suitable for valid thyroglobulin determinations, bind less than 6% of the radiolabeled thyroglobulin. (biomedsearch.com)
  • Strong evidence exists that autoantibodies are important in development of SLE, a systemic autoimmune disease characterized by immune-mediated injury that affects a large number of tissues, including brain, blood vessels, and kidneys. (jci.org)
  • Autoantibodies damage body tissues by bringing about the phagocytosis (ingestion) or lysis (bursting) of healthy cells. (britannica.com)
  • Traditionally, many laboratories relied on indirect immunofluorescence (IIF) using neural tissues such as hippocampus and cerebellum in which distinctive patterns of staining provided clues to the identity of the autoantibody. (aacc.org)
  • In some cases, the use of another tissue can help differentiate autoantibody systems that have similar staining patterns of neural tissues. (aacc.org)
  • Additionally, approximately 10% of phenotypic T2DM patients are positive for at least one of the islet autoantibodies , and this group is often referred to as latent autoimmune DM in adults (LADA). (thefreedictionary.com)
  • The host factors that are targeted by autoantibodies produced by SLE patients are not fully understood. (medicalxpress.com)
  • These tests together confirmed that the IgG autoantibodies specific for galactose-deficient IgA1 are unique for immunodeposits of patients with IgA nephropathy. (newswise.com)
  • These IgG autoantibodies specific for galactose-deficient IgA1are present also in blood of patients with IgA nephropathy, and the autoantibody levels predict disease progression. (newswise.com)
  • Thus, we can measure these autoantibodies in blood to identify patients who could benefit from a future disease-specific therapy, or monitor patients for responses to the therapy," Novak said. (newswise.com)
  • Refractory Hypertension associated with autoantibodies to beta1-adrenergic receptors has been documented in diabetic patients. (wikipedia.org)
  • Other: Experimental studies observed that activating autoantibodies to the beta1/2-adrenergic and M2 muscarinic receptors are associated with atrial tachyarrhythmias in patients with hyperthyroidism. (wikipedia.org)
  • Future research solidifying this correlation of CFS with autoantibodies to adrenergic receptors would be useful to clinicians tackling this difficult-to-treat condition that affects 200,000 people per year in the US. (wikipedia.org)
  • Some autoantibodies do not cause tissue injury directly but are thought to be part of an overall immune response that can cause inflammation and damage. (labcorp.com)
  • In non-atopic asthma, viral airway infection, as well as chronic eosinophilic inflammation of the airways, may cause some trouble in the impaired lymphocyte surveillance and may be especially liable to develope autoantibodies under those circumstances. (nii.ac.jp)
  • Disorders caused by autoantibodies that primarily affect a single organ, such as the thyroid in Graves disease or Hashimoto thyroiditis, are often easier to diagnose. (labcorp.com)
  • Autoantibodies have been intensively evaluated in this respect and have led to the classification of AIH into three serological subgroups: antinuclear and smooth muscle antibody-positive (ANA/SMA, type 1), liver-kidney microsomal antibody-positive (LKM-1, type 2), and soluble liver antigen/liver-pancreas antigen antibody-positive (SLA/LP, type 3) AIH. (omicsonline.org)
  • Autoantibodies also interfere with the normal functioning of cells. (britannica.com)
  • Anti-thyroglobulin autoantibodies, when present even in low concentrations, interfere with thyroglobulin determination. (biomedsearch.com)
  • The range of autoantibodies found in pSS is constantly expanding, but their significance is not fully established. (intechopen.com)
  • One or more autoantibodies may be produced by a person's immune system when it fails to distinguish between "self" and "non-self. (labcorp.com)
  • Autoantibodies are created by the immune system when it fails to distinguish between "self" and "nonself. (diabetesjournals.org)
  • Recently, a number of excellent reviews of autoantibodies in neurological diseases have been published (1-10). (aacc.org)
  • Associated pathologies: Cardiovascular diseases and events: Circulating autoantibodies to adrenergic receptors have been identified in numerous heart diseases and cardiac symptoms. (wikipedia.org)
  • Laboratory models have revealed a mechanism by which adrenergic autoantibodies accomplish their effects on the cardiovascular system. (wikipedia.org)