AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Aurora KinasesAurora Kinase AAurora Kinase BAurora Kinase CProtein-Serine-Threonine KinasesProtein Kinase InhibitorsMitosisProtein KinasesPhosphatidylinositol 3-KinasesMAP Kinase Signaling SystemSpindle ApparatusChromosome SegregationPhosphorylationCalcium-Calmodulin-Dependent Protein KinasesPiperazinesCell Line, TumorKinetochoresAzepinessrc-Family KinasesOrganophosphatesBenzamidesCell Cycle ProteinsM Phase Cell Cycle CheckpointsProtein Kinase CCentrosomeCytokinesisp38 Mitogen-Activated Protein KinasesPolyploidyCyclic AMP-Dependent Protein KinasesMitogen-Activated Protein Kinase 1ChondromaHeLa CellsAneugensMicrotubule-Associated ProteinsApoptosisPyrimidinesCell CycleHistonesp21-Activated KinasesCell ProliferationCDC2 Protein KinaseMitogen-Activated Protein Kinase KinasesJNK Mitogen-Activated Protein KinasesCell Cycle CheckpointsMitogen-Activated Protein Kinase 3Antineoplastic AgentsPyrazolesAnaphaseMutationProtein-Tyrosine KinasesMicrotubulesCollagen Type XIChromosomal Proteins, Non-HistoneCyclin-Dependent KinasesBlastodiscCreatine KinaseQuinazolinesMAP Kinase Kinase KinasesEnzyme InhibitorsPotoroidaeRNA, Small InterferingeIF-2 KinaseCasein Kinase IICasein KinasesProtein BindingBlotting, WesternCell Physiological ProcessesPyruvate KinaseRibosomal Protein S6 KinasesMolecular Sequence DataSignal TransductionAmino Acid SequenceMAP Kinase Kinase 1CentromereReceptor Protein-Tyrosine KinasesThymidine KinaseExtracellular Signal-Regulated MAP KinasesMAP Kinase Kinase 4Microtubule-Organizing CenterPloidiesGene Expression Regulation, EnzymologicEnzyme ActivationRNA InterferenceNuclear Proteins1-Phosphatidylinositol 4-KinasePhosphotransferases (Alcohol Group Acceptor)NeoplasmsGlycogen Synthase Kinase 3Mitogen-Activated Protein KinasesCDC2-CDC28 KinasesProto-Oncogene ProteinsMeiosisXenograft Model Antitumor AssaysIsoenzymesI-kappa B Kinaserho-Associated KinasesDrug SynergismAneuploidyChromosomesProtein Kinase C-delta
Aurora Kinases
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.
Aurora Kinase A
An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION.
Aurora Kinase B
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. It mediates proper CHROMOSOME SEGREGATION and contractile ring function during CYTOKINESIS.
Aurora Kinase C
Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. It is found primarily in GERM CELLS in the TESTIS, and may mediate CHROMOSOME SEGREGATION during SPERMATOGENESIS.
Protein-Serine-Threonine Kinases
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
Protein Kinase Inhibitors
Agents that inhibit PROTEIN KINASES.
Mitosis
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
Protein Kinases
A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
Phosphatidylinositol 3-Kinases
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
MAP Kinase Signaling System
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Spindle Apparatus
A microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.
Chromosome Segregation
The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.
Phosphorylation
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Calcium-Calmodulin-Dependent Protein Kinases
A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)
Piperazines
Cell Line, Tumor
A cell line derived from cultured tumor cells.
Kinetochores
Large multiprotein complexes that bind the centromeres of the chromosomes to the microtubules of the mitotic spindle during metaphase in the cell cycle.
Azepines
Seven membered heterocyclic rings containing a NITROGEN atom.
src-Family Kinases
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
Organophosphates
Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.
Benzamides
BENZOIC ACID amides.
Cell Cycle Proteins
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
M Phase Cell Cycle Checkpoints
The cellular signaling system that halts the progression of cells through MITOSIS or MEIOSIS if a defect that will affect CHROMOSOME SEGREGATION is detected.
Protein Kinase C
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Centrosome
The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).
Cytokinesis
The process by which the CYTOPLASM of a cell is divided.
p38 Mitogen-Activated Protein Kinases
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
Polyploidy
The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.
Cyclic AMP-Dependent Protein Kinases
A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.
Mitogen-Activated Protein Kinase 1
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
Chondroma
A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)
HeLa Cells
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Aneugens
Agents which affect CELL DIVISION and the MITOTIC SPINDLE APPARATUS resulting in the loss or gain of whole CHROMOSOMES, thereby inducing an ANEUPLOIDY.
Microtubule-Associated Proteins
High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Pyrimidines
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Histones
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
p21-Activated Kinases
A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.
Cell Proliferation
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
CDC2 Protein Kinase
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
Mitogen-Activated Protein Kinase Kinases
A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
JNK Mitogen-Activated Protein Kinases
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
Cell Cycle Checkpoints
Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable.
Mitogen-Activated Protein Kinase 3
A 44-kDa extracellular signal-regulated MAP kinase that may play a role the initiation and regulation of MEIOSIS; MITOSIS; and postmitotic functions in differentiated cells. It phosphorylates a number of TRANSCRIPTION FACTORS; and MICROTUBULE-ASSOCIATED PROTEINS.
Antineoplastic Agents
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Pyrazoles
Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.
Anaphase
The phase of cell nucleus division following METAPHASE, in which the CHROMATIDS separate and migrate to opposite poles of the spindle.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Protein-Tyrosine Kinases
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
Microtubules
Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.
Collagen Type XI
A fibrillar collagen found primarily in interstitial CARTILAGE. Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits.
Chromosomal Proteins, Non-Histone
Nucleoproteins, which in contrast to HISTONES, are acid insoluble. They are involved in chromosomal functions; e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens.
Cyclin-Dependent Kinases
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
Blastodisc
A small whitish spot on the surface of the EGG YOLK where cleavage begins. Upon fertilization the cytoplasm streams from the vegetal pole away from the yolk to the animal pole where cleavage will occur. This germinal area eventually flattens into a layer of cells (BLASTODERM) that covers the yolk completely.
Creatine Kinase
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Quinazolines
MAP Kinase Kinase Kinases
Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Potoroidae
A family of rat kangaroos found in and around Australia. Genera include Potorous and Bettongia.
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
eIF-2 Kinase
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
Casein Kinase II
A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulatory subunit. Casein kinase II has been shown to phosphorylate a large number of substrates, many of which are proteins involved in the regulation of gene expression.
Casein Kinases
A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Blotting, Western
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Cell Physiological Processes
Cellular functions, mechanisms, and activities.
Pyruvate Kinase
ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
Ribosomal Protein S6 Kinases
A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
MAP Kinase Kinase 1
An abundant 43-kDa mitogen-activated protein kinase kinase subtype with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 1 and MITOGEN-ACTIVATED PROTEIN KINASE 3.
Centromere
The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.
Receptor Protein-Tyrosine Kinases
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
Thymidine Kinase
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
Extracellular Signal-Regulated MAP Kinases
A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
MAP Kinase Kinase 4
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.
Microtubule-Organizing Center
An amorphous region of electron dense material in the cytoplasm from which the MICROTUBULES polymerization is nucleated. The pericentriolar region of the CENTROSOME which surrounds the CENTRIOLES is an example.
Ploidies
The degree of replication of the chromosome set in the karyotype.
Gene Expression Regulation, Enzymologic
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
Enzyme Activation
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Nuclear Proteins
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
1-Phosphatidylinositol 4-Kinase
An enzyme that catalyzes the conversion of phosphatidylinositol (PHOSPHATIDYLINOSITOLS) to phosphatidylinositol 4-phosphate, the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.
Phosphotransferases (Alcohol Group Acceptor)
A group of enzymes that transfers a phosphate group onto an alcohol group acceptor. EC 2.7.1.
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Glycogen Synthase Kinase 3
A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.
Mitogen-Activated Protein Kinases
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
CDC2-CDC28 Kinases
A family of cell cycle-dependent kinases that are related in structure to CDC28 PROTEIN KINASE; S CEREVISIAE; and the CDC2 PROTEIN KINASE found in mammalian species.
Proto-Oncogene Proteins
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Meiosis
A type of CELL NUCLEUS division, occurring during maturation of the GERM CELLS. Two successive cell nucleus divisions following a single chromosome duplication (S PHASE) result in daughter cells with half the number of CHROMOSOMES as the parent cells.
Xenograft Model Antitumor Assays
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
Isoenzymes
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
I-kappa B Kinase
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
rho-Associated Kinases
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Drug Synergism
The action of a drug in promoting or enhancing the effectiveness of another drug.
Aneuploidy
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
Chromosomes
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Protein Kinase C-delta
A ubiquitously expressed protein kinase that is involved in a variety of cellular SIGNAL PATHWAYS. Its activity is regulated by a variety of signaling protein tyrosine kinase.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Cell Division
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Protein Kinase C-alpha
A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.
Transfection
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Intracellular Signaling Peptides and Proteins
Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.
Drug Resistance, Neoplasm
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Models, Biological
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Gene Expression Regulation, Neoplastic
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Molecular Targeted Therapy
Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.
G2 Phase
The period of the CELL CYCLE following DNA synthesis (S PHASE) and preceding M PHASE (cell division phase). The CHROMOSOMES are tetraploid in this point.
Cyclin B1
A cyclin B subtype that colocalizes with MICROTUBULES during INTERPHASE and is transported into the CELL NUCLEUS at the end of the G2 PHASE.
Cell Survival
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Diacylglycerol Kinase
An enzyme of the transferase class that uses ATP to catalyze the phosphorylation of diacylglycerol to a phosphatidate. EC 2.7.1.107.
Drug Screening Assays, Antitumor
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
AMP-Activated Protein Kinases
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Mice, Nude
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Chordata
Phylum in the domain Eukarya, comprised of animals either with fully developed backbones (VERTEBRATES), or those with notochords only during some developmental stage (CHORDATA, NONVERTEBRATE).
Kinetics
The rate dynamics in chemical or physical systems.
Tumor Cells, Cultured
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Phosphoproteins
Imidazoles
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Substrate Specificity
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Proto-Oncogene Proteins c-akt
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Saccharomycetales
An order of fungi in the phylum Ascomycota that multiply by budding. They include the telomorphic ascomycetous yeasts which are found in a very wide range of habitats.
Serine
A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
Focal Adhesion Kinase 1
A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
Down-Regulation
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Pyridines
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Myosin-Light-Chain Kinase
An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.
Thiazoles
Janus Kinase 2
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
Oocytes
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
Recombinant Fusion Proteins
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Focal Adhesion Protein-Tyrosine Kinases
A family of non-receptor, PROLINE-rich protein-tyrosine kinases.
Microscopy, Fluorescence
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Ribosomal Protein S6 Kinases, 90-kDa
A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.
Tyrosine
A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.
Reverse Transcriptase Polymerase Chain Reaction
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Protein Kinase C-epsilon
A protein kinase C subtype that was originally characterized as a CALCIUM-independent, serine-threonine kinase that is activated by PHORBOL ESTERS and DIACYLGLYCEROLS. It is targeted to specific cellular compartments in response to extracellular signals that activate G-PROTEIN-COUPLED RECEPTORS; TYROSINE KINASE RECEPTORS; and intracellular protein tyrosine kinase.
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Chromosomal Instability
An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
MAP Kinase Kinase Kinase 1
A 195-kDa MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It is found localized in the CYTOSKELETON and can activate a variety of MAP kinase-dependent pathways.
Calcium-Calmodulin-Dependent Protein Kinase Type 2
A multifunctional calcium-calmodulin-dependent protein kinase subtype that occurs as an oligomeric protein comprised of twelve subunits. It differs from other enzyme subtypes in that it lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE.
Saccharomyces cerevisiae Proteins
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
Tumor Suppressor Protein p53
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Catalytic Domain
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
Protein Kinase C beta
PKC beta encodes two proteins (PKCB1 and PKCBII) generated by alternative splicing of C-terminal exons. It is widely distributed with wide-ranging roles in processes such as B-cell receptor regulation, oxidative stress-induced apoptosis, androgen receptor-dependent transcriptional regulation, insulin signaling, and endothelial cell proliferation.

Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. (1/1165)

We earlier isolated cDNAs encoding novel human protein kinases AIK and AIK2 sharing high amino acid sequence identities with Drosophila Aurora and Saccharomyces cerevisiae Ipl1 kinases whose mutations cause abnormal chromosome segregation. In the present study, a third human cDNA (AIK3) highly homologous to aurora/IPL1 was isolated, and the nucleotide sequence was determined. This cDNA encodes 309 amino acids with a predicted molecular mass of 35.9 kDa. C-terminal kinase domain of AIK3 protein shares high amino acid sequence identities with those of Aurora/Ipl1 family protein kinases including human AIK, human AIK2, Xenopus pEg2, Drosophila Aurora, and yeast Ipl1, whereas the N-terminal domain of AIK3 protein shares little homology with any other Aurora/Ipl1 family members. AIK3 gene was assigned to human chromosome 19q13.43, which is a frequently deleted or rearranged region in several tumor tissues, by fluorescence in situ hybridization, somatic cell hybrid panel, and radiation hybrid cell panel. Northern blot analyses revealed that AIK3 expression was limited to testis. The expression levels of AIK3 in several cancer cell lines were elevated severalfold compared with normal fibroblasts. In HeLa cells, the endogenous AIK3 protein level is low in G1/S, accumulates during G2/M, and reduces after mitosis. Immunofluorescence studies using a specific antibody have shown that AIK3 is localized to centrosome during mitosis from anaphase to cytokinesis. These results suggest that AIK3 may play a role(s) in centrosome function at later stages of mitosis.  (+info)

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. (2/1165)

Chromosome segregation depends on kinetochores, the structures that mediate chromosome attachment to the mitotic spindle. We isolated mutants in IPL1, which encodes a protein kinase, in a screen for budding yeast mutants that have defects in sister chromatid separation and segregation. Cytological tests show that ipl1 mutants can separate sister chromatids but are defective in chromosome segregation. Kinetochores assembled in extracts from ipl1 mutants show altered binding to microtubules. Ipl1p phosphorylates the kinetochore component Ndc10p in vitro and we propose that Ipl1p regulates kinetochore function via Ndc10p phosphorylation. Ipl1p localizes to the mitotic spindle and its levels are regulated during the cell cycle. This pattern of localization and regulation is similar to that of Ipl1p homologs in higher eukaryotes, such as the human aurora2 protein. Because aurora2 has been implicated in oncogenesis, defects in kinetochore function may contribute to genetic instability in human tumors.  (+info)

Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. (3/1165)

Ark1p (actin regulating kinase 1) was identified as a yeast protein that binds to Sla2p, an evolutionarily conserved cortical actin cytoskeleton protein. Ark1p and a second yeast protein, Prk1p, contain NH2-terminal kinase domains that are 70% identical. Together with six other putative kinases from a number of organisms, these proteins define a new protein kinase family that we have named the Ark family. Lack of both Ark1p and Prk1p resulted in the formation of large cytoplasmic actin clumps and severe defects in cell growth. These defects were rescued by wild-type, but not by kinase-dead versions of the proteins. Elevated levels of either Ark1p or Prk1p caused a number of actin and cell morphological defects that were not observed when the kinase-dead versions were overexpressed instead. Ark1p and Prk1p were shown to localize to actin cortical patches, making these two kinases the first signaling proteins demonstrated to be patch components. These results suggest that Ark1p and Prk1p may be downstream effectors of signaling pathways that control actin patch organization and function. Furthermore, results of double-mutant analyses suggest that Ark1p and Prk1p function in overlapping but distinct pathways that regulate the cortical actin cytoskeleton.  (+info)

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. (4/1165)

A centrosomal serine/threonine kinase, AIK1(3)/breast tumor amplified kinase/aurora2, which was recently identified as an oncogene, shows high amino acid identity with chromosome segregation kinases, fly Aurora, and yeast Ipl1. Immunohistochemical analyses of invasive ductal adenocarcinomas of the breast revealed that overexpression of AIK1 was observed in 94% of the cases, irrespective of the histopathological type, whereas the protein was not detected in normal ductal and lobular cells. Benign breast lesions including fibrocystic disease and fibroadenoma (epithelial components) displayed weakly detectable AIK1 expression in part of the lesions. This is the first immunohistochemical report of AIK1 expression in primary human breast carcinomas. Although the physiological function(s) of AIK1 kinase during cell division remains to be determined, the markedly high positivity of AIK1 staining in the cancer lesions suggested a possible involvement of its overexpression in the tumorigenesis of some of breast cancer cells.  (+info)

The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5. (5/1165)

We have previously reported on the cloning of XlEg5, a Xenopus laevis kinesin-related protein from the bimC family (Le Guellec, R., Paris, J., Couturier, A., Roghi, C., and Philippe, M. (1991) Mol. Cell. Biol. 11, 3395-3408) as well as pEg2, an Aurora-related serine/threonine kinase (Roghi, C., Giet, R., Uzbekov, R., Morin, N., Chartrain, I., Le Guellec, R., Couturier, A., Doree, M., Philippe, M., and Prigent, C. (1998) J. Cell Sci. 111, 557-572). Inhibition of either XlEg5 or pEg2 activity during mitosis in Xenopus egg extract led to monopolar spindle formation. Here, we report that in Xenopus XL2 cells, pEg2 and XlEg5 are both confined to separated centrosomes in prophase, and then to the microtubule spindle poles. We also show that pEg2 co-immunoprecipitates with XlEg5 from egg extracts and XL2 cell lysates. Both proteins can directly interact in vitro, but also through the two-hybrid system. Furthermore immunoprecipitated pEg2 were found to remain active when bound to the beads and phosphorylate XlEg5 present in the precipitate. Two-dimensional mapping of XlEg5 tryptic peptides phosphorylated in vivo first confirmed that XlEg5 was phosphorylated by p34(cdc2) and next revealed that in vitro pEg2 kinase phosphorylated XlEg5 on the same stalk domain serine residue that was phosphorylated in metabolically labeled XL2 cells. The kinesin-related XlEg5 is to our knowledge the first in vivo substrate ever reported for an Aurora-related kinase.  (+info)

Stu-7/air-2 is a C. elegans aurora homologue essential for chromosome segregation during embryonic and post-embryonic development. (6/1165)

We have isolated a new sterile uncoordinated C. elegans mutant, stu-7, which is defective in post-embryonic cell divisions in a regionally-specific fashion. The anterior of the worm is relatively unaffected whereas the mid-body and/or posterior are markedly thin, often resulting in worms having a central 'waist'. We have cloned stu-7 and found that it encodes a member of the recently expanding aurora sub-family of serine/threonine kinases. Elimination of maternal as well as zygotic stu-7 expression reveals that stu-7 is essential for mitosis from the first embryonic cell cycle onwards and is required for chromosome segregation though not for centrosome separation or for setting up a bipolar spindle. Multicopy expression of stu-7 also causes mitotic defects, suggesting that the level of this protein must be tightly controlled in order to maintain genetic stability during development.  (+info)

Cdc20 associates with the kinase aurora2/Aik. (7/1165)

Cdc20/fizzy family proteins are involved in activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent proteolysis of cell cycle regulatory proteins such as anaphase inhibitors and mitotic cyclins, leading to chromosome segregation and exit from mitosis. Previous work has shown that human Cdc20 (hCdc20/p55CDC) associates with one or more kinases. We report here that Cdc20-associated myelin basic protein kinase activity peaks sharply in early M phase (embryonic cells) or in G2 phase (somatic cells). In HeLa cells, Cdc20 is associated with the kinase aurora2/Aik. Aurora2/Aik is a member of the aurora/Ipl1 family of kinases that, like Cdc20, previously has been shown to be localized at mitotic spindle poles and is involved in regulating chromosome segregation and maintaining genomic stability. The demonstration that Cdc20 is associated with aurora2/Aik suggests that some function of Cdc20 is carried out or regulated through its association with aurora2/Aik.  (+info)

Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. (8/1165)

The conserved Ipl1 protein kinase is essential for proper chromosome segregation and thus cell viability in the budding yeast Saccharomyces cerevisiae. Its human homologue has been implicated in the tumorigenesis of diverse forms of cancer. We show here that sister chromatids that have separated from each other are not properly segregated to opposite poles of ipl1-2 cells. Failures in chromosome segregation are often associated with abnormal distribution of the spindle pole-associated Nuf2-GFP protein, thus suggesting a link between potential spindle pole defects and chromosome missegregation in ipl1 mutant cells. A small fraction of ipl1-2 cells also appears to be defective in nuclear migration or bipolar spindle formation. Ipl1 associates, probably directly, with the novel and essential Sli15 protein in vivo, and both proteins are localized to the mitotic spindle. Conditional sli15 mutant cells have cytological phenotypes very similar to those of ipl1 cells, and the ipl1-2 mutation exhibits synthetic lethal genetic interaction with sli15 mutations. sli15 mutant phenotype, like ipl1 mutant phenotype, is partially suppressed by perturbations that reduce protein phosphatase 1 function. These genetic and biochemical studies indicate that Sli15 associates with Ipl1 to promote its function in chromosome segregation.  (+info)

Method of determination of cancer cell drug sensitivity towards Aurora kinase inhibitors and overcoming their resistance |...Method of determination of cancer cell drug sensitivity towards Aurora kinase inhibitors and overcoming their resistance |...
Recently, Aurora kinases (A, B, and C/serine threonine kinases) gained much attention due to their implication in several types of cancers. Aurora kinases are involved in multiple functions in mitosis. Aurora A is involved in mitotic entry, separation of centriole pairs, accurate bipolar spindle assembly, alignment of metaphase chromosomes and completion of cytokinesis. Aurora B is a chromosomal passenger protein involved in the regulation of chromosomal orientation, and regulating the association between kinetochores and microtubules, and cytokinesis. Aurora C exhibits similar functions to those assigned to Aurora B and is required for cytokinesis. The above mentioned functions are directly involved in maintaining genomic stability. The relation between Aurora kinases overexpression and transformation has been reported in many cancers. Aurora A was shown to overexpress in colorectal, renal, melanoma, and breast cancers. Mainly Aurora B was shown to overexpress in colorectal cancer. Aurora B was ...
http://imtm.cz/method-determination-cancer-cell-drug-sensitivity-towards-aurora-kinase-inhibitors-and-overcoming-0
Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis | Journal of Cell Biology | Rockefeller...Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis | Journal of Cell Biology | Rockefeller...
Aurora B kinase is essential for faithful chromosome segregation during mitosis. During (pro)metaphase, Aurora B is concentrated at the inner centromere by the kinases Haspin and Bub1. However, how Haspin and Bub1 collaborate to control Aurora B activity at centromeres remains unclear. Here, we show that either Haspin or Bub1 activity is sufficient to recruit Aurora B to a distinct chromosomal locus. Moreover, we identified a small, Bub1 kinase-dependent Aurora B pool that supported faithful chromosome segregation in otherwise unchallenged cells. Joined inhibition of Haspin and Bub1 activities fully abolished Aurora B accumulation at centromeres. While this impaired the correction of erroneous KT-MT attachments, it did not compromise the mitotic checkpoint, nor the phosphorylation of the Aurora B kinetochore substrates Hec1, Dsn1, and Knl1. This suggests that Aurora B substrates at the kinetochore are not phosphorylated by centromere-localized pools of Aurora B, and calls for a reevaluation of ...
https://rupress.org/jcb/article-abstract/doi/10.1083/jcb.201907087/133700/Untangling-the-contribution-of-Haspin-and-Bub1-to
Aurora Kinases as Anticancer Drug Targets | Clinical Cancer ResearchAurora Kinases as Anticancer Drug Targets | Clinical Cancer Research
Whether aurora A or aurora B is the better anticancer drug target is a matter of debate (8). At least two groups have directly addressed this question in the laboratory. Warner et al. (36) compared the effects of aurora A and aurora B antisense oligonucleotides in pancreatic cancer cells and found that aurora A-targeted therapy may be preferable to aurora B targeting, as shown by mitotic arrest and the rapid induction of apoptosis. Girdler et al. (37) compared the effects of RNA interference and small molecules targeting aurora A versus aurora B in colon cancer cells and found that the cells tested were extremely sensitive to aurora B inhibition. Interestingly, dual inhibition of aurora A and B results in phenotypes identical to inactivation of aurora B alone (28). Using RNA interference experiments, Yang et al. (38) showed that inactivation of aurora B indeed bypasses the requirement for aurora A and leads to polyploidy, indicating that aurora B is responsible for mitotic arrest in the absence ...
http://clincancerres.aacrjournals.org/content/14/6/1639.long
Aurora Kinases as Anticancer Drug Targets | Clinical Cancer ResearchAurora Kinases as Anticancer Drug Targets | Clinical Cancer Research
Whether aurora A or aurora B is the better anticancer drug target is a matter of debate (8). At least two groups have directly addressed this question in the laboratory. Warner et al. (36) compared the effects of aurora A and aurora B antisense oligonucleotides in pancreatic cancer cells and found that aurora A-targeted therapy may be preferable to aurora B targeting, as shown by mitotic arrest and the rapid induction of apoptosis. Girdler et al. (37) compared the effects of RNA interference and small molecules targeting aurora A versus aurora B in colon cancer cells and found that the cells tested were extremely sensitive to aurora B inhibition. Interestingly, dual inhibition of aurora A and B results in phenotypes identical to inactivation of aurora B alone (28). Using RNA interference experiments, Yang et al. (38) showed that inactivation of aurora B indeed bypasses the requirement for aurora A and leads to polyploidy, indicating that aurora B is responsible for mitotic arrest in the absence ...
https://clincancerres.aacrjournals.org/content/14/6/1639?ijkey=ca22c4abb4014e2b3b93bb1b9886b5edf692f89b&keytype2=tf_ipsecsha
Aurora B kinase - WikipediaAurora B kinase - Wikipedia
Aurora B kinase is a protein that functions in the attachment of the mitotic spindle to the centromere. Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004).[supplied by OMIM] In cancerous cells, over-expression of these enzymes causes unequal distribution of genetic information, creating aneuploid cells, a hallmark of cancer. In 1998, Aurora kinase B was identified in humans by a polymerase chain reaction screen for kinases that are overexpressed in cancers. In the same year, rat Aurora kinase B was identified in a screen designed to find kinases that altered S. cerevisiae proliferation when overexpressed. The expression and activity of Aurora B are regulated ...
https://en.wikipedia.org/wiki/Aurora_B_kinase
PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer | Molecular...PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer | Molecular...
Aurora kinases play distinct roles during mitosis, with Aurora A being essential for centrosome maturation and spindle assembly and Aurora B functioning at kinetochores in chromosome attachment and at the end of mitosis in cytokinesis (reviewed in refs. 3, 4).. Inhibition of Aurora kinases is emerging as a new strategy for anticancer therapy, and several small-molecule inhibitors have entered clinical trials. In this report, we describe the biochemical and pharmacologic activity profile of PHA-739358, a spectrum-selective small-molecule kinase inhibitor, which was identified during a screen for inhibitors of Aurora kinases. In most of the cell lines tested, cells fail to divide, resulting in polyploidy without a strong impact on the timing of mitosis (data not shown) and finally leading to a reduction in viability. In some cell lines, an increased apoptosis was seen. This speaks for a dominant Aurora B kinase-related mechanism of action for inhibition because Aurora A inhibition would rather ...
https://mct.aacrjournals.org/content/6/12/3158?ijkey=4efee7aed5d7868efe626f0a9f6710a9e99f0db9&keytype2=tf_ipsecsha
PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer | Molecular...PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer | Molecular...
Aurora kinases play distinct roles during mitosis, with Aurora A being essential for centrosome maturation and spindle assembly and Aurora B functioning at kinetochores in chromosome attachment and at the end of mitosis in cytokinesis (reviewed in refs. 3, 4).. Inhibition of Aurora kinases is emerging as a new strategy for anticancer therapy, and several small-molecule inhibitors have entered clinical trials. In this report, we describe the biochemical and pharmacologic activity profile of PHA-739358, a spectrum-selective small-molecule kinase inhibitor, which was identified during a screen for inhibitors of Aurora kinases. In most of the cell lines tested, cells fail to divide, resulting in polyploidy without a strong impact on the timing of mitosis (data not shown) and finally leading to a reduction in viability. In some cell lines, an increased apoptosis was seen. This speaks for a dominant Aurora B kinase-related mechanism of action for inhibition because Aurora A inhibition would rather ...
https://mct.aacrjournals.org/content/6/12/3158?ijkey=5525043d7bfdde628b11f74017350e5e878ba6ed&keytype2=tf_ipsecsha
The S. pombe aurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for...The S. pombe aurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for...
We have characterised the role played by the aurora-related kinase Ark1 in regulating mitotic progression in fission yeast. In contrast to metazoans, where aurora A is required for spindle formation and aurora B required for both chromosome condensation and cytokinesis, a single aurora kinase, Ark1, is required for mitosis in S. pombe. The phenotypes arising in cells that lack Ark1 suggest that this single kinase is performing functions that are related to the functions of each of the two isoforms in higher systems. The spindle formation defects of ark1.Δ1 cells resemble the consequences of perturbing aurora A function in Drosophila and Xenopus (Glover et al., 1995; Roghi et al., 1998), while the lack of chromosome resolution during anaphase resembles aurora B deficiencies in C. elegans and Drosophila (Adams et al., 2001b; Giet and Glover, 2001; Kaitna et al., 2000; Severson et al., 2000b). Although we failed to detect a requirement for Ark1 during cytokinesis, it remains a possibility that, ...
https://jcs.biologists.org/content/114/24/4371?ijkey=89ab666dca9f6ec1595d5250c06f2cb0e54efbc1&keytype2=tf_ipsecsha
Aurora Kinase | Cell Cycle|Epigenetics| CSNpharmAurora Kinase | Cell Cycle|Epigenetics| CSNpharm
Aurora kinases are serine/threonine kinases that are essential for cell proliferation. Aurora kinase helps the dividing cell dispense its genetic materials to its daughter cells. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. Three Aurora kinases have been identified in mammalian cells to date, Aurora A, Aurora B, Aurora C. Besides being implicated as mitotic regulators, these three kinases have generated significant interest in the cancer research field due to their elevated expression profiles in many human cancers.
https://www.csnpharm.com/aurora-kinase.html
Specific distribution of overexpressed aurora B kinase during interphase of normal epithelial cells | ScholarBank@NUSSpecific distribution of overexpressed aurora B kinase during interphase of normal epithelial cells | [email protected]
Background: It is known that aurora B, a chromosomal passenger protein responsible for the proper progression of mitosis and cytokinesis, is overexpressed throughout the cell cycle in cancer cells. Overexpression of aurora B produced multinuclearity and induced aggressive metastasis, suggesting that overexpressed aurora B has multiple functions in cancer development. However, the detailed dynamics and functions of overexpressed aurora B are poorly understood. Results: We overexpressed GFP fused aurora B kinase in normal rat kidney epithelial cells. Using spinning disk confocal microscopy, we found that overexpressed aurora B-GFP was predominantly localized in the nucleus and along the cortex as a dot-like or short filamentous structure during interphase. Time-lapse imaging revealed that a cytoplasmic fraction of overexpressed aurora B-GFP was incorporated into the nucleus after cell division. Immunofluorescence showed that the nuclear fraction of overexpressed aurora B did not induce ectopic ...
http://scholarbank.nus.edu.sg/handle/10635/130423
Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates | ScienceSensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates | Science
Successful cell division requires that chromosomes attach to opposite poles of the mitotic spindle (bi-orientation). Aurora B kinase regulates chromosome-spindle attachments by phosphorylating kinetochore substrates that bind microtubules. Centromere tension stabilizes bi-oriented attachments, but how physical forces are translated into signaling at individual centromeres is unknown. Using fluorescence resonance energy transfer-based biosensors to measure localized phosphorylation dynamics in living cells, we found that phosphorylation of an Aurora B substrate at the kinetochore depended on its distance from the kinase at the inner centromere. Furthermore, repositioning Aurora B closer to the kinetochore prevented stabilization of bi-oriented attachments and activated the spindle checkpoint. Thus, centromere tension can be sensed by increased spatial separation of Aurora B from kinetochore substrates, which reduces phosphorylation and stabilizes kinetochore microtubules.. ...
http://science.sciencemag.org/content/323/5919/1350
SAR156497 | CAS#1256137-14-0 | 1375795-62-2 | Aurora inhibitor | | MedKoo BiosciencesSAR156497 | CAS#1256137-14-0 | 1375795-62-2 | Aurora inhibitor | | MedKoo Biosciences
SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A); 1 nM (Aurora B / incenp); 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP 3A4 and PDE3 inhibition. In vitro, SAR156497 displayed high antiproliferative activity on a large panel of tumor cell lines without correlation with any particular genetic signature or Aurora kinases expression. It induced significant modulation of Aurora A and Aurora B biomarkers (p-Aurora A and pHH3, respectively) and cell polyploidy, as expected from Aurora A/B inhibitors. In vivo efficacy has been demonstrated on relevant tumor models, but unfortunately, SAR156497 displayed a narrow therapeutic window.
http://www.medkoo.com/products/6318
Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development | Molecular and Cellular BiologyAurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development | Molecular and Cellular Biology
Aurora B, the catalytic component of the chromosomal passenger complex (CPC), is an essential kinase in the error correction mechanism that ensures proper chromosome segregation when cells divide (8, 35). Reducing Aurora B activity by means of RNA interference or small-molecule inhibitors results in failure in chromosome alignment and defective kinetochore-microtubule attachment, cleavage furrow formation, and cytokinesis, ultimately leading to tetraploidization (36-39). Aurora B heterozygosity in the mouse results in increased tumor incidence, whereas complete loss of Aurkb prevents chromosome segregation and results in a premature mitotic exit (26, 34).. Although most studies have used loss-of-function approaches to understand the function of this kinase, Aurora B is overexpressed in many tumor types, and a correlation between its levels and tumor grade or poor clinical prognosis has been also proposed (16-18, 20-22). Previous cellular studies indicate that sustained overexpression of Aurora B ...
https://mcb.asm.org/content/35/20/3566.long
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Background: Aurora kinases are promising targets for cancer chemotherapy. Many reports have been published that some cancers overexpress Aurora kinases, which correlates with tumor grade and poor prognosis. Hence Aurora kinases were considered key genes for cancerogenesis and progression. Many Aurora kinase inhibitors(AKI,s) are in various phases of pre-clinical and clinical development and promising anticancer effects have been reported. Tumor resistance remains one of the major problems in chemotherapy.. Objectives: Our work is mainly aimed at identification of potential resistance mechanisms towards CYC116 (new small molecule pan Aurora kinase inhibitor) and ZM447439. The main aims include generation and selection of resistant tumor cell clones, characterization of resistance, cross resistance with other AKI,s and multidrug resistance. Further characterization of the resistant clones included cell cycle analysis, expression and DNA sequencing of Aurora kinases, cellular target inhibition, and ...
http://cancerres.aacrjournals.org/content/71/8_Supplement/735
Aurora Kinase A (Aurora 2 or Serine/Threonine Protein Kinase 15 or Serine/Threonine Protein Kinase 6 or Serine/Threonine...Aurora Kinase A (Aurora 2 or Serine/Threonine Protein Kinase 15 or Serine/Threonine Protein Kinase 6 or Serine/Threonine...
Aurora Kinase A Pipeline Review H2 Market 2019. Aurora Kinase A Pipeline Review H2 Market Size by Types, Applications, Major Regions and Major Manufacturers including the capacity, production, price, revenue, cost, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies.
https://www.grandresearchstore.com/life-sciences/aurora-kinase-a-pipeline-review-h-2018-654
aurora university reviews
76 Jobs. 13 talking about this. Find Aurora University reviews, tuition costs and how many students are enrolled at Aurora University in Illinois. View All num of num Close (Esc) Aurora University. Companies. Program Details. $38,798. Founded as a seminary in 1893, Aurora University has expanded its mission to build an inclusive community based on four values: integrity, citizenship, continuous learning and excellence. The Bachelor of Science in Nursing training program at Aurora University incorporates a solid foundation in the sciences with professional training and also significant clinical experiences. Aurora University . Aurora University - Dunham School of Business , Student reviews, Accreditation, Tuition fees and Scholarships, Price and Cost, Rankings, Application, Admission requirements, Curriculum, Class profile, Salary and Jobs, GMAT,IELTS and TOEFL scores Note: there are allegations of misconduct involving Aurora Police Brass and corrupt Aurora Mayor Tom Weisner to cover up … ...
http://meselflove.com/598z74/aurora-university-reviews-b4a429
Aurora kinases comprise a family group of highly conserved serine-threonine proteins - Synthetic Small Molecule Inhibitors of...Aurora kinases comprise a family group of highly conserved serine-threonine proteins - Synthetic Small Molecule Inhibitors of...
Aurora kinases comprise a family group of highly conserved serine-threonine proteins kinases that play a pivotal part in the rules of cell routine. from homozygous mutant moms. The mutants recognized were given titles linked to the polar areas, and included not merely but also the similarly famous gene was initially found out in the past due 1980s within a seek out genes regulating cell routine development (Glover, 1989; Glover et al., 1989, 1995). Since that time, Aurora kinases possess emerged as important players in the rules of cell department (for review observe Carmena et al., 2009). The original steady circulation of publications quickly accelerated as paralogs in various species were found out and new features designated to them. The obtaining of elevated degrees of Auroras in malignancy cells soon activated the introduction of little molecule inhibitors of the kinases (Hauf et al., 2003; Harrington et al., 2004). This as well was to become field where research output offers increased ...
http://biosweepny.com/aurora-kinases-comprise-a-family-group-of-highly-conserved-serine-threonine-proteins/
AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor...AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor...
The Aurora family of serine-threonine kinases are essential regulators of cell division in mammalian cells. Aurora-A and -B expression and kinase activity is elevated in a variety of human cancers and is associated with high proliferation rates and poor prognosis. AMG 900 is a highly potent and selective pan-aurora kinase inhibitor that has entered clinical evaluation in adult patients with advanced cancers. In mice, oral administration of AMG 900 blocks the phosphorylation of histone H3 on serine-10 (p-Histone H3), a proximal substrate of aurora-B and inhibits the growth of multiple human tumor xenografts, including multidrug-resistant models. In order to establish a preclinical pharmacokinetic-pharmacodynamic (PK-PD) relationship for AMG 900 that could be translated to the clinic, we used flow cytometry and laser scanning cytometry detection platforms to assess the effects on p-Histone H3 inhibition in terms of sensitivity, precision, and specificity, in human tumor xenografts in conjunction with
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-014-0307-x/metrics
Aurora B Kinase Enzyme SystemAurora B Kinase Enzyme System
Recombinant full-length human Aurora B was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. Aurora B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation.
https://www.promega.com/products/cell-signaling/kinase-assays-and-kinase-biology/aurora-b-kinase-enzyme-system/
Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia<...
TY - JOUR. T1 - Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. AU - Katsha, Ahmed. AU - Soutto, Mohammed. AU - Sehdev, Vikas. AU - Peng, Dunfa. AU - Washington, M. Kay. AU - Piazuelo, M. Blanca. AU - Tantawy, Mohammed N.. AU - Manning, H. Charles. AU - Lu, Pengcheng. AU - Shyr, Yu. AU - Ecsedy, Jeffrey. AU - Belkhiri, Abbes. AU - El-Rifai, Wael. PY - 2013/1/1. Y1 - 2013/1/1. N2 - Background & Aims Chronic inflammation contributes to the pathogenesis of gastric tumorigenesis. The aurora kinase A (AURKA) gene is frequently amplified and overexpressed in gastrointestinal cancers. We investigated the roles of AURKA in inflammation and gastric tumorigenesis. Methods We used quantitative real-time reverse transcription polymerase chain reaction, immunofluorescence, immunohistochemistry, luciferase reporter, immunoblot, co-immunoprecipitation, and in vitro kinase assays to analyze AGS and MKN28 gastric cancer cells. We also analyzed Tff1-/- mice, growth of ...
https://miami.pure.elsevier.com/en/publications/aurora-kinase-a-promotes-inflammation-and-tumorigenesis-in-mice-a
A VX-680 (an Aurora Kinase Inhibitor) Study in Patients With Advanced Cancer (0457-002) - Full Text View - ClinicalTrials.govA VX-680 (an Aurora Kinase Inhibitor) Study in Patients With Advanced Cancer (0457-002) - Full Text View - ClinicalTrials.gov
The purpose of this study is to assess the safety and tolerability of MK-0457(VX-680), an Aurora kinase inhibitor, in participants with advanced solid tumors. Bioavailability of the oral formulation will also be assessed. The primary study hypothesis is that administration of MK-0457 is sufficiently safe and tolerated to permit further study ...
https://clinicaltrials.gov/show/NCT00104351
Aurora Kinase Inhibitor AT9283 in Treating Patients With Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma -...Aurora Kinase Inhibitor AT9283 in Treating Patients With Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma -...
OUTLINE: This is an open-label, dose-escalation, multicenter study.. Patients receive Aurora kinase inhibitor AT9283 (AT9283) IV over 24 hours on days 1 and 8 . Treatment repeats every 3 weeks in the absence of disease progression or unacceptable toxicity.. Cohorts of 3-6 patients receive escalating doses of AT9283 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which at least 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. The dose preceding the MTD is the recommended phase II dose (RPTD). Up to 8 additional patients are treated at the RPTD.. Patients treated at the RPTD undergo skin and tumor tissue biopsy and blood collection at baseline and on days 2 and/or 3. Samples are examined by pharmacokinetic and pharmacodynamic analysis, including immunohistochemistry, immunocytochemistry, western blotting, immunoenzyme techniques, flow cytometry, and reverse transcriptase-polymerase chain reaction, for biological markers.. After completion of ...
https://clinicaltrials.gov/ct2/show/NCT00443976
aurora kinase inhibitor III | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYaurora kinase inhibitor III | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
The IUPHAR/BPS Guide to Pharmacology. aurora kinase inhibitor III ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=structure&ligandId=5931
StudyPages - Cisplatin and Gemcitabine Hydrochloride (Chemotherapy drugs) with and without ATR Kinase Inhibitor VX-970 ...StudyPages - Cisplatin and Gemcitabine Hydrochloride (Chemotherapy drugs) with and without ATR Kinase Inhibitor VX-970 ...
This study looks at how well cisplatin and gemcitabine hydrochloride, with or without ATR kinase inhibitor VX-970 works in treating patients with urothelial cancer that has spread to other places in the body. Drugs used in chemotherapy, such as cisplatin and gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. ATR kinase inhibitor VX-970 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known if cisplatin and gemcitabine hydrochloride work better alone or with ATR kinase inhibitor VX-970 in treating patients with urothelial cancer. ...
https://studypages.com/s/cisplatin-and-gemcitabine-hydrochloride-chemotherapy-drugs-with-and-without-atr-kinase-inhibitor-vx-970-experimental-medicine-564615/?ref=gallery
Cancer Drug Target: Aurora B | Sino BiologicalCancer Drug Target: Aurora B | Sino Biological
Aurora B is expressed at high level in primary human colorectal cancers and other cancer cell lines. Sino Biological offers Aurora B protein, Aurora B antibody, Aurora B gene and Aurora B ELISA kit.
https://www.sinobiological.com/research/cancer-drug-targets/aurora-b
Hesperadin | ≥99%(HPLC) | Selleck | Aurora Kinase inhibitor ...Hesperadin | ≥99%(HPLC) | Selleck | Aurora Kinase inhibitor ...
Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. Find all the information about Hesperadin for cell signaling research.
https://www.selleckchem.com/products/Hesperadin.html
Reactome | Chromosome passenger complex [cytosol]Reactome | Chromosome passenger complex [cytosol]
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
http://www.reactome.org/content/detail/R-MMU-377879
Breasting Aurora As malignancy | Journal of Cell ScienceBreasting Aurora As malignancy | Journal of Cell Science
Aurora A (serine/threonine kinase 6) is overexpressed in many pre-invasive and invasive breast carcinomas. High expression of Aurora A is strongly associated with decreased survival in patients with breast cancer, but the molecular mechanisms that underlie Aurora-A-associated malignancy are poorly understood. Here, Kavita Shah and co-workers (p. 2711) use a new chemical genetic approach to identify the pleckstrin-homology-like domain protein PHLDA1 as a putative Aurora A target. The authors confirm previous reports that PHLDA1 is frequently downregulated in primary breast cancers and, in addition, show that PHLDA1 downregulation is associated with oestrogen receptor expression in breast carcinoma. Aurora A directly phosphorylates PHLDA1, which leads to its degradation, but PHLDA1 also negatively regulates Aurora A, thereby setting up a feedback loop. Finally, they show that PHLDA1 upregulation and Aurora A inhibition act synergistically to promote cell death, and that PHLDA1 strongly inhibits ...
http://jcs.biologists.org/content/124/16/e1601
aurora advocate login | LiveWell - Login Page
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Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation...Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation...
At the outset of this work, the existence of a second aurora-like gene in Drosophila, aurora B, was already known (previously named ial; Reich et al. 1999), but there were no known mutations at the locus and the enzyme had not been localized within cells. The proximity of other genes made the prospect of generating such mutations by classical genetic means somewhat daunting and although a model system for the targeted disruption of genes has recently been developed (Rong and Golic 2000), this is also a time-consuming and not yet widely used procedure. In several organisms dsRNAi has offered opportunities for studying the genetic basis of many aspects of cell biology in the absence of mutations in the genes directing these activities. This has been perhaps best demonstrated in C. elegans, where the technique is most widely used (Hunter 1999, Hunter 2000). A simple system for dsRNAi in cultured Drosophila cells not only offers the means of eliminating specific gene expression (Caplen et al. 2000; ...
http://jcb.rupress.org/content/152/4/669
Aurora kinases: shining lights on the therapeutic horizon?Aurora kinases: shining lights on the therapeutic horizon?
The Aurora kinases have been implicated in tumorigenesis and are important regulators of diverse cell cycle events, ranging from the entry into mitosis, centrosome function, mitotic spindle formation, chromosome biorientation and segregation, and cytokinesis. The recent identification of novel bindi …
https://pubmed.ncbi.nlm.nih.gov/16049526/?dopt=Abstract
Novel, dual-targeted small molecule inhibitor of PKC and Aurora A kinase against cancer | Channels - McGill UniversityNovel, dual-targeted small molecule inhibitor of PKC and Aurora A kinase against cancer | Channels - McGill University
Invention 14075 Novel, dual-targeted small molecule inhibitor of PKC and Aurora A kinase against cancer A small molecule inhibitor of protein kinase c and aurora a kinase in cancer models has been produced at McGill University. Market Need In cancer progression, tumors alter a number of cellular functions such as mobility, cell death, and proliferation. Two proteins that are commonly associated with some of these cellular pathways in tumor progression are aurora A kinase and protein kinase C. Aurora A kinase controls cell cycle progression and mitosis by interacting with different proteins. Protein kinase C regulates multiple features of tumor growth, including proliferation, survival, differentiation, and motility. Since even combination therapy often develops drug resistance, there is a great need for an inhibitor that targets multiple pathways. Technology Summary This technology is a small molecule inhibitor that is able to selectively target both Protein kinase C and Aurora A kinase in low
https://www.mcgill.ca/channels/channels/news/novel-dual-targeted-small-molecule-inhibitor-pkc-and-aurora-kinase-against-cancer-301555
Drug that interrupts a key stage of cell division shows promise in patients with advanced solid tumoursDrug that interrupts a key stage of cell division shows promise in patients with advanced solid tumours
Once the dose levels reached 190 mg/m2, tests on skin biopsies showed that the drug was inhibiting the aurora B protein - in other words it was beginning to do what we expected it to.. The aurora B protein is responsible for phosphorylating histone H3 - a protein involved in the structure of chromatin (the strands of DNA that make up chromosomes) in cells. Inhibition of aurora B results in the inhibition of phosphorylation of histone H3, thereby blocking that step in cell division. This study shows, for the first time, that the aurora kinase inhibitor PHA-739358 inhibits phosphorylation of histone H3 in the skin of patients, and therewith provides a proof for its (or one of its) mechanisms of action.. The researchers are continuing to recruit patients in order to define the safety of the drug and the recommended dose for subsequent studies. However, they believe the results so far are promising.. The clinical trial has proved the concept that inhibition of the aurora protein disrupts an ...
http://www.innovations-report.com/html/reports/life-sciences/report-73691.html
Plus itPlus it
5648 The Aurora family of serine/threonine kinases (Aurora A, Aurora B, and Aurora C) plays a key role in cells orderly progression through mitosis. Elevated expression levels of Aurora kinases have been detected in a high percentage of melanoma, colon, breast, ovarian, gastric, and pancreatic tumors, and in a subset of these tumors the AURKA locus (20q13) is amplified. SNS-314, a novel aminothiazole-derived urea, is a selective inhibitor of Aurora kinases A, B, and C with IC50 values in the low nanomolar range. SNS-314 potently inhibits cell proliferation and induces polyploidy (, 4N DNA) in a diverse panel of human cancer cell lines. In the present study we investigated the pharmacodynamic effects and in vivo activity of SNS-314 in human tumor xenograft models. SNS-314 displayed potent anti-tumor activity in HCT-116 (colon), PC-3 (prostate), CALU-6 (NSCLC) and MDA-MB-231 (breast) models. Tumor growth inhibition in these xenograft models ranged from 67.5 to 96.6% on a bi-weekly administration ...
http://cancerres.aacrjournals.org/content/68/9_Supplement/5648
Seamus Haji Vs Junk DNA & Olic Featuring The Frontrunnaz - After Midnight (Aurora Lights) FLAC
Seamus Haji Vs Junk DNA & Olic Featuring The Frontrunnaz - After Midnight (Aurora Lights) | After Midnight Aurora Lights Seamus Haji Vocal Mix,After Midnight Aurora Lights Sheldon Remix,After Midnight Aurora Lights David Noakes Vocal Mix,After Midnight Aurora Lights Haji Sheldon Vs David Noakes Rem download flac album free
https://eurocall2015.it/Seamus-Haji/After-Midnight-Aurora-Lights/147788
The Aurora Kinase A polymorphisms are not associated with recurrencefree survival in prostate cancer patients - Fingerprint ...The Aurora Kinase A polymorphisms are not associated with recurrencefree survival in prostate cancer patients - Fingerprint ...
Fingerprint Dive into the research topics of The Aurora Kinase A polymorphisms are not associated with recurrencefree survival in prostate cancer patients. Together they form a unique fingerprint. ...
https://ohsu.pure.elsevier.com/en/publications/the-aurora-kinase-a-polymorphisms-are-not-associated-with-recurre/fingerprints/
Redox priming promotes Aurora A activation during mitosis | Science SignalingRedox priming promotes Aurora A activation during mitosis | Science Signaling
Cell cycle-dependent redox changes can mediate transient covalent modifications of cysteine thiols to modulate the activities of regulatory kinases and phosphatases. Our previously reported finding that protein cysteine oxidation is increased during mitosis relative to other cell cycle phases suggests that redox modifications could play prominent roles in regulating mitotic processes. The Aurora family of kinases and their downstream targets are key components of the cellular machinery that ensures the proper execution of mitosis and the accurate segregation of chromosomes to daughter cells. In this study, x-ray crystal structures of the Aurora A kinase domain delineate redox-sensitive cysteine residues that, upon covalent modification, can allosterically regulate kinase activity and oligomerization state. We showed in both Xenopus laevis egg extracts and mammalian cells that a conserved cysteine residue within the Aurora A activation loop is crucial for Aurora A activation by ...
https://stke.sciencemag.org/content/13/641/eabb6707
Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motorsSpindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors
The spindle checkpoint is the prime cell-cycle control mechanism that ensures sister chromatids are bioriented before anaphase takes place. Aurora B kinase, the catalytic subunit of the chromosome passenger complex, both destabilizes kinetochore attachments that do not generate tension and simultane …
https://pubmed.ncbi.nlm.nih.gov/21664573/
October | 2015 | Thrombin Inhibitors
ributed cell populations in G0 G1, S and G2 M phases. In contrast, OE33 and markedly OE19 and EPC hTERT cells selleck compound had a high G0 G1 phase population, with reduced S and G2 M phase populations. Aurora kinases in normal esophageal epithelial cells and esophageal cancer cells For Aurora A, fluorescence in situ hybridization revealed chromosome 20 polysomy with concomitantly elevated Aurora A gene copy num bers in OE21, OE33 and OE19 cells and an Aurora A gene amplification with up to nine Aurora A gene copies in Kyse 410 cells. In view of their Aurora A gene amplification, Kyse 410 cells also showed highest Aur ora A mRNA and high protein expression. In contrast, OE21, OE33 and OE19 cells exhibited lower Aurora A mRNA expression, despite chromosome 20 polysomy.. Still, high Aurora A protein expression was seen in OE33, but not OE21 and OE19 cells. Active Aurora A was hardly detectable in Inhibitors,Modulators,Libraries immunoblot analysis, but weak Aur ora A phosphoT288 levels were seen ...
http://thrombininhibitors.com/2015/10
Aurora Kinase Inhibitors Products|Active Biopharma Corp
Inhibitors,Activator,Agonist,antagonist,API,Aurora,Metabolic Disease,VEGFR-PDGFR,Other Intermediate,Others,MOF Chemicals,,Active Biopharma Corp
http://activebiopharma.com/category68/list1.html
MK-0457 Alone and in Combination With Docetaxel Inhibits Ovarian Cancer Growth In Vivo | Libbys H*O*P*E*
...[T]he [M.D. Anderson Cancer Center & Baylor College of Medicine] researchers concluded that [Aurora kinase] AK inhibition [produced by MK-0457] significantly reduces ovarian cancer tumor burden and cell proliferation, and increases tumor cell apoptosis in preclinical ovarian cancer mouse models. The researchers noted that the role of Aurora kinase inhibition in ovarian cancer merits further…
https://libbyshope.com/2008/09/07/mk-0457-alone-and-in-combination-with-docetaxel-inhibits-ovarian-cancer-growth-in-vivo/
The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint -...The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint -...
Full text for this publication is not currently held within this repository. Alternative links are provided below where available. ...
http://eprint.ncl.ac.uk/pub_details2.aspx?pub_id=164143
Low Cost Lawn Care & Mowing Service in Aurora, CO | CVSHomeLow Cost Lawn Care & Mowing Service in Aurora, CO | CVSHome
Its important to ask about the experience of your local Aurora lawn care companys employees before you select the company for your job. Experienced lawn care experts know which species and types of grass, shrubs and plants work best in the Aurora climate, and know how to maintain them. CVSHome.com researches local pros and partners with the ones that consistently provide the highest quality of service, and also offer competitive pricing. When you hire someone to perform lawn maintenance in Aurora, make sure that you get multiple bids, and ask for references. Even a small difference in pricing can add up over the long run, especially if you are getting frequent Aurora lawn cutting service.. ...
https://cvshome.org/lawn-care-service/co/aurora.php
Open Tenders - Aurora MarketingOpen Tenders - Aurora Marketing
I recently worked together with Leann and her Aurora team preparing the tender submission documents for one of Australias largest PPP construction projects to date. From the start, the Aurora team, led with true passion by Leann and what she believes in, established themselves within the bid office and started getting processes into shape. The submission strategy, style and target, which was of course to win, were quickly established around the special requirements of the project. The team quickly assessed the unique nature of the project and Client requirements and drew on their extensive marketing experience, understanding and knowledge to come up with what we believed to be a winning formula. Leann ensured that the team was sufficiently resourced to cope with the changing demands of the very tight schedule for submission and over time, Aurora took on more tasks as our confidence in their ability grew. The Aurora team were some of the most professional people that I have had the pleasure to ...
https://auroramarketing.com.au/open-tenders/
Using multispectral optical observations to identify the acceleration mechanism responsible for flickering auroraUsing multispectral optical observations to identify the acceleration mechanism responsible for flickering aurora
We present an analysis of flickering (2-10 Hz) auroras observed with a state-of-the-art multispectral imaging system, Auroral Structure and Kinetics, located in Tromso, Norway. Short (1-2 s) periods of flickering aurora have been identified in which the frequency of the brightness oscillations decreases or increases smoothly over time. To the authors knowledge this is the first detailed analysis of such chirps in flickering aurora or field-aligned bursts. We have found that the electron precipitation energy is strongly anticorrelated with the flickering frequency during all identified chirps. This result is consistent with the theory that flickering aurora is caused by the resonance interaction between electromagnetic ion cyclotron waves and precipitating electrons and that the wave parallel phase velocity is the primary factor determining the electron acceleration produced by this mechanism. Other current theories known to the authors cannot completely explain our observations.. ...
http://kth.diva-portal.org/smash/record.jsf?pid=diva2:394563
Alcohol Abuse Rehabilitation Aurora CO - alcohol abuse, Aurora CO alcohol abuse rehabilitation, Aurora CO alcohol treatment,...
Alcohol Abuse Rehabilitation in Aurora, CO. Find phone numbers, addresses and information about Alcohol Abuse Rehabilitation in Aurora.
http://articles.directorym.com/Alcohol_Abuse_Rehabilitation_Aurora_CO-p1774983-Aurora_CO.html
Aurora Health Care Among Six Sites Chosen for National Medicare Collaborative on Geri... ( MILWAUKEE Oct. 5 /- Aurora Health...Aurora Health Care Among Six Sites Chosen for National Medicare Collaborative on Geri... ( MILWAUKEE Oct. 5 /- Aurora Health...
Health,...MILWAUKEE Oct. 5 /- Aurora Health Care is one of only si...(Logo: a hrefhttp://www.newscom.com/cgi-bin/prnh/20090303/CG78204L... We selected Aurora Health Care because of its track record in develop... Its an honor to be included in this group of medical schools and hea...,Aurora,Health,Care,Among,Six,Sites,Chosen,for,National,Medicare,Collaborative,on,Geriatric,Care,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
http://www.bio-medicine.org/medicine-news-1/Aurora-Health-Care-Among-Six-Sites-Chosen-for-National-Medicare-Collaborative-on-Geriatric-Care-58886-1/
Aurora B-INCENP localization at centromeres/inner kinetochores is required for chromosome bi-orientation in budding yeast<...
TY - JOUR. T1 - Aurora B-INCENP localization at centromeres/inner kinetochores is required for chromosome bi-orientation in budding yeast. AU - García-Rodríguez, Luis J.. AU - Kasciukovic, Taciana. AU - Denninger, Viola. AU - Tanaka, Tomoyuki. N1 - Funding: ERC (322682) and Wellcome Trust (096535/Z/11/Z).. PY - 2019/5/6. Y1 - 2019/5/6. N2 - For proper chromosome segregation in mitosis, sister kinetochores must interact with microtubules from opposite spindle poles (chromosome bi-orientation) [1, 2]. To promote bi-orientation, Aurora B kinase disrupts aberrant kinetochore-microtubule interactions [3-6]. It has long been debated how Aurora B halts this action when bi-orientation is established and tension is applied across sister kinetochores. A popular explanation for it is that, upon bi-orientation, sister kinetochores are pulled in opposite directions, stretching the outer kinetochores [7, 8] and moving Aurora B substrates away from Aurora-B-localizing sites at centromeres (spatial separation ...
https://discovery.dundee.ac.uk/en/publications/aurora-bincenp-localization-at-centromeresinner-kinetochores-is-r
E-GEOD-42089 - The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell cycle...
PURPOSE: Despite over 70,000 new cases of bladder cancer in the United States annually, patients with advanced disease have a poor prognosis due to limited treatment modalities. We evaluate the role of Aurora A, identified as an upregulated candidate molecule in bladder cancer, in regulating bladder tumor growth. EXPERIMENTAL DESIGN: Gene expression in human bladder cancer samples was evaluated using RNA microarray and reverse-transcriptase PCR. The specific Aurora kinase A inhibitor MLN8237 (Millennium) was used to determine effects on bladder cancer cell growth using in vitro and in vivo models using malignant T24 and UM-UC-3 and papilloma-derived RT4 bladder cells. RESULTS: Urothelial carcinoma upregulates a set of 13 mitotic spindle associated transcripts, as compared to normal urothelium, including MAD2L1 (7.6-fold), BUB1B (8.8-fold), Aurora kinases A (5.6-fold) and Aurora kinase B (6.2-fold). Application of MLN8237 (10nM-1µM) to the human bladder tumor cell lines T24 and UM-UC-3 induced dose
https://www.omicsdi.org/dataset/arrayexpress-repository/E-GEOD-42089
Divisive Tension | Science SignalingDivisive Tension | Science Signaling
Chromosome attachments to the mitotic spindle are regulated by tension across the centromere, which ensures accurate chromosome segregation. Spindle microtubules can bind chromosomes at the kinetochore in different configurations, but only bi-oriented attachments can support accurate chromosome segregation. Tension across the centromere distinguishes correct and incorrect attachments, but how tension is sensed to regulate attachments is unclear. The mitotic kinase Aurora B is a key regulator of kinetochore-microtubule attachments, and phosphorylation of Aurora B substrates at kinetochores reduces microtubule affinity. Liu et al. tested to see whether a tension-sensitive mechanism regulates Aurora B activity. Instead, their results suggest that Aurora B kinase activity is not directly regulated by tension but that phosphorylation of an Aurora B substrate at the kinetochore depends on its distance from the kinase at the inner centromere and that it is this distance that is affected by ...
https://stke.sciencemag.org/content/2/61/ec93
Regulation of kinetochore-microtubule attachments by Aurora B kinase | Biochemical Society TransactionsRegulation of kinetochore-microtubule attachments by Aurora B kinase | Biochemical Society Transactions
Accurate segregation of chromosomes in mitosis requires that spindle microtubules attach sister kinetochores to opposite poles of the mitotic spindle (biorientation). To achieve biorientation of all chromosomes, incorrect attachments are selectively destabilized, providing a fresh opportunity to biorient, whereas correct attachments are stabilized. Tension across the centromere may be the signal that distinguishes different attachment states, as spindle microtubules pull bioriented sister kinetochores in the opposite direction. Destabilization of incorrect attachments requires the Ipl1/Aurora B kinase, which phosphorylates kinetochore substrates that directly interact with microtubules. The present review focuses on how Aurora B regulates attachments in response to centromere tension.. ...
http://www.biochemsoctrans.org/content/37/5/976
Aurora kinase B | Aurora kinase B was identified in humans by a polymerase chain reaction screen for kinases that are...
T he carcinogenic risk induced by low doses of ionizing radiation is controversial. It cannot be assessed with epidemiologic methods alone because at low. doses the data are imprecise and often conflicting. Since the 1970s, the radiation protection community has estimated the risk of low doses by means of extrapolation from the risk assessed at high doses, generally by using the linear no-threshold (LNT) model.. The LNT relationship implies P5091 molecular weight proportionality between dose and cancer risk. This approach is based on one set of data and two hypotheses: (a) The relationship between. dose and DNA damage in vivo seems linear from 1 mGy to 100 Gy with use of H2AX foci as a marker for DNA double-strand breaks (DSBs)-however, this marker is not specific (1); (b) each DSB is hypothesized to have the same probability of inducing cell transformation, irrespective of the Sapanisertib quantity of DSBs present simultaneously in the cell; and (c) each transformed cell is hypothesized ...
https://aurorakinaseb.com/
Hesperadin | CAS#422513-13-1 | Aurora inhibitor | MedKoo BiosciencesHesperadin | CAS#422513-13-1 | Aurora inhibitor | MedKoo Biosciences
Hesperadin is an inhibitor of human Aurora B, which can prevent the phosphorylation of substrate with IC(50) of 40 nM. Growth of cultured bloodstream forms was also sensitive to Hesperadin (IC(50) of 50 nM). Hesperadin blocked nuclear division and cytokinesis but not other aspects of the cell cycle. Consequently, growth arrested cells accumulated multiple kinetoplasts, flagella and nucleoli, similar to the effects of RNAi-dependent knockdown of TbAUK1 in cultured bloodstream forms cells. Molecular models predicted high-affinity binding of Hesperadin to both conserved and novel sites in TbAUK1. Collectively, these data demonstrate that cell cycle progression is essential for infections with T. brucei and that parasite Aurora kinases can be targeted with small-molecule inhibitors..............
https://www.medkoo.com/products/4669
Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued | JCBAurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued | JCB
The mitotic spindle is a highly specialized macromolecular machinery that ensures equal segregation of genetic information between daughter cells during mitosis. The assembly and operation of this complex and very dynamic structure have to be appropriately regulated to avoid generation of aneuploid cells. Numerous signaling molecules participate in this regulation, and they include the Aurora A kinase. Some of the functions of the Aurora A kinase during mitotic spindle assembly are now well established; they operate in G2 when the kinase is recruited to centrosomes. Aurora A participates in centrosome maturation by recruiting NDLE1 (Mori et al., 2007) and TACC3 (Kinoshita et al., 2005). In prometaphase, Aurora A participates in regulation of microtubule dynamics by contributing to the recruitment of factors involved in the dynamic instability of microtubules, including DDA3 (Jang and Fang, 2011), MCAK (Zhang et al., 2008), ch-TOG (De Luca et al., 2008; Asteriti et al., 2011), and KIF2A (Jang et ...
http://jcb.rupress.org/content/201/1/65.full
Phase II Study Shows Activity of Selective Aurora A Kinase Inhibitor Alisertib in Relapsed/Refractory Aggressive B- and T-Cell...Phase II Study Shows Activity of Selective Aurora A Kinase Inhibitor Alisertib in Relapsed/Refractory Aggressive B- and T-Cell...
Aurora A kinase is overexpressed in aggressive lymphomas and may correlate with more histologically aggressive forms of disease. In a phase II study reported in Journal of Clinical Oncology, Jonathan W. Friedberg, MD, of University of Rochester Wilmot Cancer Center, and colleagues assessed the effects of the selective AAK inhibitor alisertib in patients with relapsed and refractory aggressive non-Hodgkin lymphoma (NHL). They found that the agent was generally well tolerated and exhibited activity that warrants further study.. Study Details. In the study, 48 patients with relapsed or refractory diffuse large B-cell lymphoma (n = 21), mantle cell lymphoma (n = 13), peripheral T-cell lymphoma (n = 8), transformed follicular lymphoma (n = 5), or Burkitts lymphoma (n = 1) were treated with oral alisertib at 50 mg twice daily for 7 days in 21-day cycles. Patients had a median age of 67.5 years, 27% were female, 98% were white, 87% had Eastern Cooperative Oncology Group performance status of 0 or 1, ...
https://www.ascopost.com/News/8582
Aurora C kinase is an essential regulator of cytokinesis seeing thatAurora C kinase is an essential regulator of cytokinesis seeing that
Aurora C kinase is an essential regulator of cytokinesis seeing that it stabilizes the intercellular channel within the midbody to ensure proper chromosomal segregation during cell department. tetraploidy, mitotic criminal arrest, and apoptosis of tumorigenic cells and inhibiting tumor formation in athymic naked rodents profoundly. These findings suggest molecular interaction between Aurora C and calmodulin in telophase and recommend that calmodulin serves as a gate sensor for chromosomal segregation PF-03814735 mistakes during mitosis. rodents/group with medication focus at 2 Meters (low), 10 Meters (moderate) and 40 Meters (high) in the consuming … Debate Lately, Steigemann et al. suggested an elegant model by which Aurora C is normally the essential regulator of abscission time, which responds to chromosome connection development by slowing down abscission to stabilize the intercellular channel until the chromosome connection is normally solved.12 In quality, a indication is provided by ...
http://researchhunt.com/2018/02/05/aurora-c-kinase-is-an-essential-regulator-of-cytokinesis-seeing-that/
Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic<...
TY - JOUR. T1 - Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic. AU - Dodson, Charlotte. AU - Bayliss, Richard. PY - 2012/1/6. Y1 - 2012/1/6. N2 - Protein kinases are activated by phosphorylation and by the binding of activator proteins. The interplay of these two factors is incompletely understood. We applied energetic analysis to this question and characterized the activation process of the serine/threonine kinase Aurora-A by phosphorylation and by its protein partner, targeting protein for Xenopus kinesin-like protein 2 (TPX2). We discovered that these two activators act synergistically and without a predefined order: each can individually increase the activity of Aurora-A, and the effect of both bound together is the exact sum of their individual contributions to catalysis. Unexpectedly, the unphosphorylated enzyme has catalytic activity that is increased 15-fold by the binding of TPX2 alone. The energetic contribution of ...
https://researchportal.bath.ac.uk/en/publications/activation-of-aurora-a-kinase-by-protein-partner-binding-and-phos
How to Cope Joints for Wood Corner Trim - Aurora Small Engine Repair Tips Aurora Small Engine Discounts and Tips
New Tip: How to Cope Joints for Wood Corner Trim - Aurora Small Engine Repair Tips Shared By Discount Small Engine Aurora Experts... New Tip: How to Cope Joints for Wood Corner TrimShared By Aurora Affordable Small Engine Experts...How to Cope Joints for Wood Corner TrimLooking for Affordable Small Engine or Repair Services in Aurora? […]
https://sewingmachinerepairauroraco.com/how-to-cope-joints-for-wood-corner-trim-aurora-small-engine-repair-tips-aurora-small-engine-discounts-and-tips/
Aurora, Ontario - WikipediaAurora, Ontario - Wikipedia
Lieutenant-Governor John Graves Simcoe gave the order for Yonge Street to be extended to Holland Landing in 1793, the first step toward the establishment of a community where Aurora now stands. Yonge Street opened between 1794 and 1796. In 1795, the first house in Aurora was built at Yonge St and Catherine Av.[5] The government began granting deeds to land in 1797. By 1801 there were fourteen homes.[6]. In 1804, Richard Machell became the first merchant at the crossroads of Yonge and Wellington and the hamlet soon became known as Machells Corners. Charles Doan was another early businessman at Machells Corners and became the first postmaster and later the first reeve. The post office was originally known as Whitchurch.[7]:10 As postmaster, he was influential in renaming the village Aurora, after the goddess Aurora from Roman mythology.[7]:10[a] Machell proposed to rename the town Match-Ville, ostensibly for the match factory in the town, but the name Aurora was more popular and ultimately ...
https://en.m.wikipedia.org/wiki/Aurora,_Ontario
Aurora Seriate Calcio - WikipediaAurora Seriate Calcio - Wikipedia
Aurora Seriate Calcio or simply Aurora Seriate was an Italian association football club, based in Seriate, Lombardy. Aurora Seriate last played in Serie D. The club was founded in 1967 and developed in the next decade within the parish dispute for several years provincial championships. In 2008, it won the championship of Prima Categoria and a historic promotion to Promozione. In the 2008-09 season in the Promozione, Aurora Seriate ended in fifth place but, due to winning the Italian Cup final category, the jump to 2009-10 Eccellenza was allowed. In Eccellenza, the first year ended in second place, behind Rudianese and losing the final of the playoffs by the later promoted Sterilgarda Castiglione. In 2010-11 Eccellenza, it won the championship and the promotion to 2011-12 Serie D. Aurora Seriate officially merged with fellow Lombardy and Serie D side FC AlzanoCene on 31 May 2015 to become Virtus Bergamo Alzano Seriate 1909. The teams colors were red and blue. Archived copy. Archived from the ...
https://en.wikipedia.org/wiki/Aurora_Seriate_Calcio
Aurora Kinases | Profiles RNS
Glant TT, Besenyei T, Kádár A, Kurkó J, Tryniszewska B, Gál J, Soós G, Szekanecz Z, Hoffmann G, Block JA, Katz RS, Mikecz K, Rauch TA. Differentially expressed epigenome modifiers, including aurora kinases A and B, in immune cells in rheumatoid arthritis in humans and mouse models. Arthritis Rheum. 2013 Jul; 65(7):1725-35 ...
https://profiles.rush.edu/display/28273
Search Results | Journal of Cell Biology | Rockefeller University PressSearch Results | Journal of Cell Biology | Rockefeller University Press
During mitosis, sister chromatids attach to microtubules from opposite poles, called biorientation. Sister chromatid cohesion resists microtubule forces, generating tension, which provides the signal that biorientation has occurred. How tension silences the surveillance pathways that prevent cell cycle progression and correct erroneous kinetochore-microtubule attachments remains unclear. Here we show that SUMOylation dampens error correction to allow stable sister kinetochore biorientation and timely anaphase onset. The Siz1/Siz2 SUMO ligases modify the pericentromere-localized shugoshin (Sgo1) protein before its tension-dependent release from chromatin. Sgo1 SUMOylation reduces its binding to protein phosphatase 2A (PP2A), and weakening of this interaction is important for stable biorientation. Unstable biorientation in SUMO-deficient cells is associated with persistence of the chromosome passenger complex (CPC) at centromeres, and SUMOylation of CPC subunit Bir1 also contributes to timely ...
https://rupress.org/jcb/search-results?f_Authors=Michael+Tatham
Mller (Reviews, 27 Oct 2006, p. yielding monopolar spindles or bipolar | barasertib Mediated Aurora Kinase B InhibitionMller (Reviews, 27 Oct 2006, p. yielding monopolar spindles or bipolar | barasertib Mediated Aurora Kinase B Inhibition
Mller (Reviews, 27 Oct 2006, p. yielding monopolar spindles or bipolar spindles missing centrosomes, in keeping with earlier observations (7,8). Therefore delays mitotic development inside a SAC-dependent way. The simplest description for SAC activation is usually that inhibition of -TuRC induces spindle problems that prevent kinetochores from attaining complete MT occupancy and/or arriving under tension. Nevertheless, the writers argue that simple explanation isnt sufficient to describe their observations, saying that -TuRCCdeficient cells display abundant microtubule arrays with amphitelic-like chromosome micro-tubule connection. Rather, they hypothesize that -tubulin is usually a part of a signaling complicated that creates the SAC when -TuRC protein are abrogated. SAC activation in -TuRCCdeficient cells argues against the hypothesis that -tubulin can be an activator from the SAC, although inside a formal feeling, -TuRC proteins become negative regulators from the SAC, as will additionally ...
https://barasertib.info/mller-reviews-27-oct-2006-p-yielding-monopolar-spindles-or-bipolar/
Differential requirement of Ldha in Myc-induced tumorigenesis based on cooperating oncogenic lesion and tumor immunogenicityDifferential requirement of Ldha in Myc-induced tumorigenesis based on cooperating oncogenic lesion and tumor immunogenicity
Myc oncogenes encode transcription factors that bind to E-box sequences in DNA, driving the expression of a large number of target genes and are deregulated in approximately 70% of human cancers. Deregulated Myc expression cause enhanced proliferation (which is counteracted by apoptosis), angiogenesis and cancer. Though Mycs importance in induction of S phase has been established, less is known about its functions in the G2 and M phases of the cell cycle. Paper I addresses the targeting of the Myc targets Aurora kinase A and B that have roles in G2/M transition and provide evidence that pharmaceutical Aurora kinase inhibition causes cell cycle arrest and apoptosis in a Myc-selective manner and is useful in treating Myc-induced lymphomas in vivo.. The assumption that the important target genes responsible for the biological effects of Myc overexpression were those encoding components of the cell cycle machinery lead to little interest in other potentially important groups of target genes. ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:300919
an 80 kDaleukocyte-endothelial cell adhesion molecule 1 LECAM-1).CD62L is expressed on most peripheral blood B cells |...an 80 kDaleukocyte-endothelial cell adhesion molecule 1 LECAM-1).CD62L is expressed on most peripheral blood B cells |...
Supplementary MaterialsSupplementary material 1 (AVI 412 kb) 13238_2017_407_MOESM1_ESM. regulators of mitosis. Aurora kinase B (AurkB) is usually ubiquitously expressed while Aurora kinase C (AurkC) is usually specifically expressed in gametes and preimplantation embryos. Decitabine price We found that increasing AurkC level in one blastomere of the 2-cell embryo accelerated cell division and decreasing AurkC level slowed down mitosis. Changing AurkB level experienced the opposite effect. The kinase domains of AurkB and AurkC were responsible for their different ability to phosphorylate Histone H3 Serine 10 (H3S10P) and regulate metaphase timing. Using an Oct4-photoactivatable GFP fusion protein (Oct4-paGFP) and fluorescence decay after photoactivation assay, we found that AurkB overexpression reduced Oct4 retention in the nucleus. Finally, we show that blastomeres with higher AurkC level elevated pluripotency gene expression, which were inclined to enter the inner cell mass lineage and ...
https://healthyfutureforkids.com/tag/an-80-kdaleukocyte-endothelial-cell-adhesion-molecule-1-lecam-1-cd62l-is-expressed-on-most-peripheral-blood-b-cells/
Decitabine price | Antagonists development strategies and therapeutic applicationsDecitabine price | Antagonists development strategies and therapeutic applications
Supplementary MaterialsSupplementary material 1 (AVI 412 kb) 13238_2017_407_MOESM1_ESM. regulators of mitosis. Aurora kinase B (AurkB) is usually ubiquitously expressed while Aurora kinase C (AurkC) is usually specifically expressed in gametes and preimplantation embryos. Decitabine price We found that increasing AurkC level in one blastomere of the 2-cell embryo accelerated cell division and decreasing AurkC level slowed down mitosis. Changing AurkB level experienced the opposite effect. The kinase domains of AurkB and AurkC were responsible for their different ability to phosphorylate Histone H3 Serine 10 (H3S10P) and regulate metaphase timing. Using an Oct4-photoactivatable GFP fusion protein (Oct4-paGFP) and fluorescence decay after photoactivation assay, we found that AurkB overexpression reduced Oct4 retention in the nucleus. Finally, we show that blastomeres with higher AurkC level elevated pluripotency gene expression, which were inclined to enter the inner cell mass lineage and ...
https://healthyfutureforkids.com/tag/decitabine-price/
Plus itPlus it
The second query is aimed to identify proteins overexpressed in cancer as compared with its normal cellular counterpart. Based on the list of candidate cancer proteins identified by Polanski and Anderson (22), a search was made to investigate whether any proteins on this list were expressed at high levels in at least six of 12 colorectal cancer patients, whereas the expression in normal glandular cells in the colon is low (Fig. 4B). Again four proteins fit these criteria. The first protein is the serine/threonine-protein kinase 12 (Aurora-B), also known as Aurora-related kinase 2. The Aurora kinases associate with microtubules during chromosome movement and segregation, and this protein localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. The tissue profiles of the Human Protein Atlas show strong expression in six of 12 colon cancers, and the expression is, as expected, in the nuclei. The protein is also expressed highly in a subset of lung ...
https://www.mcponline.org/content/7/10/2019
ACLU of Colorado Statement on the Aurora Independent Investigation Into Elijah McClains Death - ACLU of ColoradoACLU of Colorado Statement on the Aurora Independent Investigation Into Elijah McClains Death - ACLU of Colorado
February 23, 2021. DENVER - The following statement can be attributed to Mark Silverstein, Legal Director for ACLU of Colorado.. The Aurora independent investigation report confirms in stark terms what the community has long understood: Aurora police killed Elijah McClain. Mr. McClain was the innocent victim of multiple violations of longstanding law that is supposed to limit the authority of law enforcement. Aurora police had no grounds to stop Mr. McClain in the first place. They had no grounds to put their hands on him. They had no legal justification for a pat-down frisk. They had no legal basis to force him to the ground. They had no adequate basis to direct paramedics to administer an excessive dose of ketamine into Mr. McClains system without his consent. As for the in-house investigation that exonerated the officers, which is more aptly labeled a coverup, the report explains that the Aurora police who investigated their colleagues asked the wrong question and fed suggested answers ...
https://aclu-co.org/aclu-of-colorado-statement-on-the-aurora-independent-investigation-into-elijah-mcclains-death/
Aurora Labs goes public and delves into 3D printing in agriculture - 3D Printing IndustryAurora Labs goes public and delves into 3D printing in agriculture - 3D Printing Industry
According to a recent interview with University of Western Australia professor Tim Sercombe, who has been working closely with Aurora Labs as they develop their printers, The skill set that farmers have in the machinery and the mechanical side of things will lend itself very nicely to operate the [Aurora Labs] machine. As seen in the demonstration video, the learning curve for these kinds of machines is not very high, allowing for easy application for those who possess minimal skills in the area.. Can this solve key issues in the industry?. Aurora Labs printers have the ability to print using DED (directed energy deposition) processes with metals such as aluminum, titanium and stainless steel. As metals are readily accessible, this can potentially solve key logistic issues in the agricultural sector, giving farmers the opportunity to directly take control of their own supply chain when necessary.. Additionally, the implications of Aurora Labs printers in agribusiness go even further when one ...
https://3dprintingindustry.com/news/aurora-labs-goes-public-delves-3d-printing-agriculture-94213/
Pilates Classes Aurora IL - anatomy, Aurora IL Pilates, Aurora IL Degenerated discs, Aurora IL prolapsed discs, Aurora IL ...Pilates Classes Aurora IL - anatomy, Aurora IL Pilates, Aurora IL Degenerated discs, Aurora IL prolapsed discs, Aurora IL ...
Pilates is a physical fitness system that seeks to increase the strength, flexibility and control of the body. A pilates class provides a great way to learn pilates method. You can take pilates classes at a pilates studio as well as at a gyms and fitness clubs. This website provides more information on pilates, pilates classes and pilates studios.
http://neighborhood.pilates-pro.com/Pilates_Classes_Aurora_IL-p3482-Aurora_IL.html
Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger...Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/22267324
Rabbit polyclonal to PDK4 | barasertib Mediated Aurora Kinase B InhibitionRabbit polyclonal to PDK4 | barasertib Mediated Aurora Kinase B Inhibition
Background Autoantibodies against the second extracellular cycle of the 1-adrenergic receptor (1-AA) not only contribute to increased susceptibility to center failing, but also play a causative function in myocardial remodeling through their sympathomimetic-like results that are induced upon holding to the 1-adrenergic receptor. CCK-8 sets and CFSE assay. Traditional western blotting was utilized to evaluate the movement of phospho-VASP and phospho-p38 MAPK. Outcomes 1-AA improved the growth of Testosterone levels lymphocytes. This impact could end up being obstructed by the picky 1-adrenergic receptor villain metoprolol, PKA inhibitor L89, and g38 MAPK inhibitor SB203580. Furthermore, the expression of the phosphorylated forms of phospho-p38 and phospho-VASP MAPK were markedly increased in the presence of 1-AA. 1-AA also inhibited the release of interferon- (IFN-) while marketing an boost in interleukin-4 (IL-4) amounts. A conclusion These outcomes demonstrate that 1-AA singled out from DCM ...
https://barasertib.info/tag/rabbit-polyclonal-to-pdk4/
Species at Risk Public Registry - COSEWIC Assessment and Update Status Report on the Aurora Trout in CanadaSpecies at Risk Public Registry - COSEWIC Assessment and Update Status Report on the Aurora Trout in Canada
Aurora Trout are distinguished from other Brook Trout mainly in terms of skin colouration: (1) adult Aurora Trout lack the yellow spots and vermiculations that typically occur on the dorsal surface of other Brook Trout; and (2) the numerous red spots surrounded by blue halos characteristically found on the sides of Brook Trout are greatly reduced in number or are absent on Aurora Trout
http://www.sararegistry.gc.ca/default.asp?lang=En&n=63A54E7E-1&offset=10&toc=show
Id1 overexpression induces tetraploidization and multiple abnormal mit by Cornelia Man, Jack Rosa et al.Id1 overexpression induces tetraploidization and multiple abnormal mit by Cornelia Man, Jack Rosa et al.
The basic helix-loop-helix transcription factor, Id1, was shown to induce tetraploidy in telomerase-immortalized nasopharyngeal epithelial cells in this study. Using both transient and stable Id1-expressing cell models, multiple mitotic aberrations were detected, including centrosome amplification, binucleation, spindle defects, and microtubule perturbation. Many of these abnormal phenotypes have previously been reported in cells overexpressing Aurora A. Further experiments showed that Id1 could stabilize Aurora A, whereas knocking down Aurora A expression in Id1-expressing cells could rescue some of the mitotic defects. The mechanisms by which Aurora A could be modulated by Id1 were explored. DNA amplification of the Aurora A locus was not involved. Id1 could only weakly activate the transcriptional activity of the Aurora A promoter. We found that Id1 overexpression could affect Aurora A degradation, leading to its stabilization. Aurora A is normally degraded from mitosis exit by the APC/C(Cdh1)
http://escholarship.umassmed.edu/gsbs_sp/1467/
Aurora Kinase B InhibitorsAurora Kinase B Inhibitors
BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVisions products are currently being sold in more than 60 countries worldwide.
https://www.biovision.com/products/epigenetics/writer-enzymes/kinases/kinase-inhibitors/aurora-kinase-b-inhibitors.html
May | 2019 | Aurora kinase B
03); **represents significant difference between. group 1%FBS + 10 ng/ml TGF-β1′ and group 1%FBS (P = 0.044). Figure 6 The effects of TGF-β1 on expression levels of PKCα and p38 MAPK. BxPC3 cells were treated with 0.1, 1 and 10 ng/ml TGF-β1 for 10 min, 30 min and 24 h. Total cellular protein was extracted and subjected to western blotting analysis to detect expression of PKCα, phosphorylated-p38/total p38 MAPK and phosphorylated-ERK1/2/total ERK1/2. Bx represents BxPC3 cells and Bx/T represents the stably transfected BxPC3 cells with TGF-β1 plasmid. To determine whether the induced PKCα activity is responsible for the TGF-β1-induced decrease in the sensitivity of BxPC3 cells to cisplatin, we treated the cells with a selective PKCα inhibitor, Gö6976, and assessed TGF-β1-induced drug resistance. We found that inhibition of PKCα. activity could partially reverse TGF-β1-induced drug resistance of BxPC3 cells to cisplatin PLX4032 in vivo (Figure 7). Figure 7 MTT assay. (A) BxPC3 ...
https://aurorakinaseb.com/2019/05
Aurora 1/48 Sopwith Camel, 102-69Aurora 1/48 Sopwith Camel, 102-69
Plastic Model Kit. Just when I think all the issues have surfaced for an Aurora kit, another one shows up! This is a 120-69 (same number as the first issue) Famous Fighters oval logo with the 69 price circle and the Parents Magazine seal. That makes this the second issue - it would have been put out in early 1957, with the very first re-imaging to the new logo. It also shows that the Parents seal was used as early as 1957 on some kits. The box artist on this issue is Jim Cox, the first model box artist for Aurora. (Please read the article about Mr. Cox on this website) This kit is part of a very successful WWI aircraft line in 1/48 scale that Aurora introduced in 56. The line sold so well that kits were added to it into the 1960s. Molded in the glossy olive drab green and black. This kit has never been started. Inventoried 100% complete with all parts, decals and instructions.
https://www.oldmodelkits.com/index.php?detail=32466&page=77&newlist=1&erl=Aurora-1-48-Sopwith-Camel-102-69
March 2017 | Aurora ClinicsMarch 2017 | Aurora Clinics
https://www.aurora-clinics.co.uk/news/pip-breast-implants-news-flash/ Visit the Aurora Clinics website for the latest news on PIP breast implants. This surgery information video is all about PIPs and what the rate of rupture is within them. The statistics at the disposal of Aurora only refers to the patients Aurora has treated with PIP implants. This statistic could well be higher […]. ...
https://www.aurora-clinics.co.uk/2017/03/
Ingenix Sells Property/Casualty Medical Review Business to Mitchell (Owned by Private Equity Firm Aurora Capital) - ...Ingenix Sells Property/Casualty Medical Review Business to Mitchell (Owned by Private Equity Firm Aurora Capital) - ...
International is a privately-held company, owned primarily by the Aurora Capital Group. Aurora Capital is a Los Angeles-based investment firm formed in 1991 that acquires and builds companies in partnership with operating management. The firm currently manages approximately $2 billion in capital and is committed to investing in companies with unique, defensible market positions. Aurora is dedicated to generating long-term value principally through investing the time and resources necessary to enhance the fundamentals of each of its businesses. . As information the algorithmic processes have been questioned and challenged here to claiming short payments with Ingenix with Safeco. This sounds like many of the law suits in court for the short pay on the out of network healthcare claims in theory. ...
http://ducknetweb.blogspot.com/2010/10/ingenix-sells-propertycasualty-medical.html
Aurora Vets at VCA Aurora Animal Hospital - SpecialtyAurora Vets at VCA Aurora Animal Hospital - Specialty
Serving Aurora, the vets of VCA Aurora Animal Hospital are ready to meet your pets health needs. Call 630-301-6100 to schedule an appointment.
https://vcahospitals.com/aurora/specialty/team/veterinarians
Body Lift Aurora | Body Lift Surgeons in Aurora ILBody Lift Aurora | Body Lift Surgeons in Aurora IL
Plastic Surgery Portal is the most trusted source for Body Lift information in Aurora. Our Illinois plastic and cosmetic surgeons have the answers to your questions about Body Lift such as recovery time, cost of surgery, and more. For the top Body Lift plastic surgeons in Aurora, were a resource you can depend on.
http://www.plasticsurgeryportal.com/specialists-by-city/aurora-il/body-lift
Conference Proceedings: Aurora Scientific Day 2020Conference Proceedings: Aurora Scientific Day 2020
Abstracts published in this supplement were among those presented at the 46th annual Aurora Scientific Day research symposium, held virtually on May 20, 2020. The symposium provides a forum for describing research studies conducted by faculty, fellows, residents, and allied health professionals affiliated with Wisconsin-based Aurora Health Care, a part of the Advocate Aurora Health health system, which publishes the Journal of Patient-Centered Research and Reviews.
https://institutionalrepository.aah.org/jpcrr/vol7/iss4/10/
Oriole Bird Feeders Aurora IL - Oriole bird feeders, Aurora IL discount oriole bird feeders, Aurora IL oriole bird houses,...
Local resource for oriole bird feeders in Aurora, IL. Includes detailed information on local businesses that provide access to oriole bird feeders, discount oriole bird feeders, oriole bird houses, and oriole bird seed, as well as advice and content on attracting orioles, identifying orioles, and oriole watching.
http://local.birdwatchersdigest.com/Oriole_Bird_Feeders_Aurora_IL-p1568014-Aurora_IL.html
Fundraiser for Dolly Earl-Smith by Alysha Chumber : Auroras AngelsFundraiser for Dolly Earl-Smith by Alysha Chumber : Auroras Angels
Please be an angel for Aurora! Aurora will be 2 years old in April and is the toughest toddler around. … Alysha Chumber needs your support for Auroras Angels
https://www.gofundme.com/f/aurora039s-angels
Diagnostic Imaging in Aurora, IL | VCA Aurora Animal Hospital - PrimaryDiagnostic Imaging in Aurora, IL | VCA Aurora Animal Hospital - Primary
Get exceptional Diagnostic Imaging services from highly experienced & loving pet care professionals in Aurora, IL. Visit VCA Aurora Animal Hospital today.
https://vcahospitals.com/aurora/primary/services/advanced-care/diagnostic-imaging
Aurora, Colorado, United States Tree Fertilization Tree Services - Tree Services in Aurora, Colorado, United States...Aurora, Colorado, United States Tree Fertilization Tree Services - Tree Services in Aurora, Colorado, United States...
Search for Aurora, Colorado, United States Tree Services specializing in Tree Fertilization and connect with Tree Fertilization Tree Services and other Tree Service Companies Professionals from Aurora, Colorado, United States.
https://www.arboristsnearme.com/united-states/colorado/aurora/tree-service/tree-fertilization
Travel Intensive Care Unit Nurse (ICU RN), Aurora, CO - Aurora jobsTravel Intensive Care Unit Nurse (ICU RN), Aurora, CO - Aurora jobs
Travel Intensive Care Unit Nurse (ICU RN) Aurora, CO Location: Aurora, CO Start Date: 9/9/2021 Shift Details: 12H Nights ( 7:00 PM-7:00 AM ) 36
https://www.aurorarecruiter.com/other-jobs/2198964301/travel-intensive-care-unit-nurse-icu-rn-aurora-co
Aurora kinaseAurora kinase
... there are three classes of aurora kinases in multicellular organisms, including humans: Aurora A (a.k.a. Aurora 2) functions ... Aurora kinases are serine/threonine kinases that are essential for cell proliferation. They are phosphotransferase enzymes that ... Aurora inhibitor Bolanos-Garcia V M. Aurora kinases. The International Journal of Biochemistry & Cell Biology 37 (2005) 1572- ... Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. Journal of Cell ...
https://en.wikipedia.org/wiki/Aurora_kinase
Aurora kinase BAurora kinase B
Aurora kinase Aurora A kinase Aurora C kinase INCENP Spindle assembly checkpoint GRCh38: Ensembl release 89: ENSG00000178999 - ... Phosphorylation of CENP-A at serine 7 by Aurora A kinase recruits Aurora B to the centromere. Aurora B, itself, can also ... The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to ... Aurora B kinase has been shown to interact with: BARD1, BIRC5, and CDCA8 TACC1. FBXL2. Abnormally elevated levels of Aurora B ...
https://en.wikipedia.org/wiki/Aurora_kinase_B
Aurora kinase CAurora kinase C
Although yeast contain only one Aurora kinase and C. elegans and Drosophila contain only two, mammals have three Aurora kinases ... "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells". Cell ... "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells". Cell ... Aurora kinase C, also Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene. This gene ...
https://en.wikipedia.org/wiki/Aurora_kinase_C
Aurora kinase AAurora kinase A
The human genome contains three members of the aurora kinase family: Aurora kinase A, Aurora kinase B and Aurora C kinase. The ... Aurora A and Aurora B kinases play important roles in mitosis. The Aurora kinase A is associated with centrosome maturation and ... Aurora A phosphorylation directs the cytoplasmic polyadenylation translation of mRNA's, like the MAP kinase kinase kinase ... contain orthologues only to Aurora A and Aurora B. In all studied species, the three Aurora mitotic kinases localize to the ...
https://en.wikipedia.org/wiki/Aurora_kinase_A
Spindle checkpointSpindle checkpoint
... strong interest has shifted towards the aurora kinase proteins. The kinase gene Aurora A when amplified acts as an oncogene ... The localization of MAD2 and BubR1 to the kinetochore may also be dependent on the Aurora B kinase. Cells lacking Aurora B fail ... Aurora-B/Ipl1 kinase of the chromosomal passenger complex functions as the tensions sensor in improper kinetochore attachments ... The Aurora-B/Ipl1 kinase is also critical in correcting merotelic attachments, where one kinetochore is simultaneously attached ...
https://en.wikipedia.org/wiki/Spindle_checkpoint
Aurora inhibitorAurora inhibitor
Aurora kinase inhibitors are a putative drug class for treating cancer. The Aurora kinase enzymes could be potential targets ... There are three mammalian aurora kinase genes, encoding aurora A, B and C. Intense investigation has focused on aurora A and B ... Aurora-B (Serine/threonine-protein kinase 12, AIK2, AIM1, ARK2, STK12) Aurora-C (Serine/threonine-protein kinase 13, AIE2, AIK3 ... Aurora kinases, so named because the scattered mitotic spindles generated by mutant forms resemble the Aurora Borealis, have ...
https://en.wikipedia.org/wiki/Aurora_inhibitor
Multipolar spindlesMultipolar spindles
Aurora kinase has two forms which are designated Aurora kinase A and Aurora kinase B. These proteins play a key role in mitosis ... In some human cancers, the expression and kinase activity of Aurora kinases have been up-regulated and has been looked into as ... A possible causes of multipolar spindle formation involve regulation of protein kinase family known as Aurora kinase. ... Jingyan Fu, Fu (26 January 2007). "Roles of Aurora Kinases in Mitosis and Tumorigenesis". Molecular Cancer Research. 5 (1): 1- ...
https://en.wikipedia.org/wiki/Multipolar_spindles
KRP (biochemistry)KRP (biochemistry)
This process is associated with Aurora B Protein Kinase. When Aurora B's function is disrupted, MCAK ability to locate ... Andrews PD, Ovechkina Y, Morrice N, Wagenbach M, Duncan K, Wordeman L, Swedlow JR (February 2004). "Aurora B regulates MCAK at ... There are other environments in which MCAK's function is impaired, absent impact on its associated kinase. For example, alpha- ...
https://en.wikipedia.org/wiki/KRP_(biochemistry)
SapacitabineSapacitabine
"Cyclin Dependent Kinase (CDK) and Aurora Kinase (AK) inhibitors , Cyclacel R&D for anticancer drugs acting on cell cycle". www. ...
https://en.wikipedia.org/wiki/Sapacitabine
HesperadinHesperadin
... works as an inhibitor, attaching to the active sites of Aurora A and Aurora B kinases. Hauf, Silke; Cole, Richard W ... Hesperadin is an aurora kinase inhibitor. The small molecule inhibits chromosome alignment and segregation by limiting the ... function of mitotic kinases Aurora B and Aurora A. Hesperadin causes cells to enter anaphase much faster, sometimes before the ... Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms". Molecular Microbiology. 72 (2): 442- ...
https://en.wikipedia.org/wiki/Hesperadin
Spindle apparatusSpindle apparatus
Aurora kinases are required for proper spindle assembly and separation. Aurora A associates with centrosomes and is believed to ... Spindle assembly is largely regulated by phosphorylation events catalyzed by mitotic kinases. Cyclin dependent kinase complexes ... with many of these proteins serving as Aurora and Polo-like kinase substrates. In a properly formed mitotic spindle, bi- ... Polo-like kinase, also known as PLK, especially PLK1 has important roles in the spindle maintenance by regulating microtubule ...
https://en.wikipedia.org/wiki/Spindle_apparatus
Midbody (cell biology)Midbody (cell biology)
MKLP1 TEX14 CEP55 Aurora Kinase B Paweletz N (January 2001). "Walther Flemming: pioneer of mitosis research". Nature Reviews. ...
https://en.wikipedia.org/wiki/Midbody_(cell_biology)
PhragmoplastPhragmoplast
"Arabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation". The Plant Cell. 23 (11): 4013-4024. doi: ... Another midline-localized protein, "two-in-on" (TIO), is a putative kinase and is also required for cytokinesis as shown by ... Oh, Sung Aeong; Bourdon, Valérie; Dickinson, Hugh G.; Twell, David; Park, Soon Ki (2014-03-01). "Arabidopsis Fused kinase TWO- ... The essential mechanism of MAPK cascade for phragmoplast expansion is suppressed by cyclin dependent kinase (CDK) activity ...
https://en.wikipedia.org/wiki/Phragmoplast
Barry James ThompsonBarry James Thompson
Bell, G.P.; Fletcher, G.C.; Brain, R.; Thompson, B.J (2015). "Aurora kinases phosphorylate Lgl to induce mitotic spindle ... columnar pseudostratified epithelial cells must round up at mitosis in a process that involves the Aurora A and B kinases, ... Aguilar-Aragon, M.; Elbediwy, A.; Foglizzo, V.; Fletcher, G.C.; Li, V.S.W; Thompson, B.J. (2018). "Pak1 Kinase Maintains Apical ... but Cdc42 appears to act primarily via activating the kinases aPKC and Pak1 in Drosophila follicle cells. His laboratory also ...
https://en.wikipedia.org/wiki/Barry_James_Thompson
Anaphase lagAnaphase lag
Aurora B is a kinase active in late metaphase, and has been shown to function as a checkpoint for the proper attachments of ... Cimini, Daniela; Wan, Xiaohu; Hirel, Christophe B.; Salmon, E.D. (2006-09-05). "Aurora Kinase Promotes Turnover of Kinetochore ... When Aurora B was partially inhibited by a small molecule drug, Cimini et al. observed lagging chromatids at increasing ... "The Ska complex promotes Aurora B activity to ensure chromosome biorientation". The Journal of Cell Biology. 215 (1): 77-93. ...
https://en.wikipedia.org/wiki/Anaphase_lag
DOT1LDOT1L
"Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcinoma". Anticancer Research. 26 (5A): 3585-93 ...
https://en.wikipedia.org/wiki/DOT1L
TPX2TPX2
... is also important in activating and recruiting Aurora A kinase, a kinase responsible for phosphorylating TPX2 and ... In the presence of nuclear import factor importin α, TPX2 is bound and prevented from binding Aurora A kinase, though it is ... TPX2 recruits and activates Aurora A kinase by utilizing its short 43 amino acid long amino-terminal sequence to bind the ... Notably, this recognition between TPX2 and Aurora A is analogous to that between the cAMP-dependent protein kinase (cAPK) ...
https://en.wikipedia.org/wiki/TPX2
Said SebtiSaid Sebti
Other kinases that have interested Sebti include Rho-associated kinase and Aurora kinase. STAT3. In 2003 the Sebti lab ... May 30, 2014). "Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation". Oncotarget. 5 (10): ... Kinases. Sebti's work on the kinase Akt led to his interest in Triciribine. ... October 1, 2012). "RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor ...
https://en.wikipedia.org/wiki/Said_Sebti
DLGAP5DLGAP5
Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase. Expression of DGL7 is found in cancer and stem ... 2005). "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A". Mol. ... Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY (July 2005). "Phosphorylation and stabilization of HURP by Aurora-A: ... implication of HURP as a transforming target of Aurora-A". Mol. Cell. Biol. 25 (14): 5789-800. doi:10.1128/MCB.25.14.5789- ...
https://en.wikipedia.org/wiki/DLGAP5
LATS2LATS2
2005). "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase". Genes Cells. 9 (5): 383-97. doi:10.1111/ ... 2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene. 24 (12): 2076-86. doi: ... Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene. This gene encodes a serine/ ... It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle ...
https://en.wikipedia.org/wiki/LATS2
TTK (gene)TTK (gene)
2006). "Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma". Int. J. Cancer. 118 (2): 357-63. doi:10.1002/ ... "Entrez Gene: TTK TTK protein kinase". Hanks SK, Quinn AM (1991). "Protein kinase catalytic domain sequence database: ... Dual specificity protein kinase TTK also known as Mps1 is an enzyme that in humans is encoded by the TTK gene. GRCh38: Ensembl ... 2003). "Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores". Mol. Biol. Cell. 14 ...
https://en.wikipedia.org/wiki/TTK_(gene)
CDCA8CDCA8
... has been shown to interact with INCENP, Survivin and Aurora B kinase. GRCh38: Ensembl release 89: ENSG00000134690 - ... "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung ...
https://en.wikipedia.org/wiki/CDCA8
DSN1DSN1
"Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore". J. Biol. Chem. 283 (39): ...
https://en.wikipedia.org/wiki/DSN1
I-motif DNAI-motif DNA
"126 Development of a new series of tricyclic pyrimido-indole inhibitors targeting Aurora kinases". European Journal of Cancer ...
https://en.wikipedia.org/wiki/I-motif_DNA
AlisertibAlisertib
... (MLN8237) is an orally available selective aurora A kinase inhibitor developed by Takeda. It was investigated as a ... a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas". Journal of ... Protein kinase inhibitors, Benzoic acids, Fluoroarenes, Abandoned drugs, Takeda Pharmaceutical Company brands, Chloroarenes, ...
https://en.wikipedia.org/wiki/Alisertib
K562 cellsK562 cells
The problem with K562 cells, and many other cancer cell types, is an overabundance of Aurora kinases. These kinases play a role ... However, the overabundance of Aurora kinases allows for uncontrolled cellular division, resulting in cancer. Inhibiting these ... This gene targets the cyclin-dependent kinase inhibitor, p21, and causes cell differentiation, cell cycle arrest in G1, and ...
https://en.wikipedia.org/wiki/K562_cells
NEDD9NEDD9
"NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of ... Interaction of NEDD9 with Aurora A kinase may also play a role in tumor invasion. NEDD9 binds to and regulates acetylation of ... NEDD9 binds directly to the Aurora-A mitotic kinase at the centrosome, and promotes its activity, allowing cells to enter ... Other phosphorylation events in this region are imposed by the kinase Aurora-A, which phosphorylates residue S296, for ...
https://en.wikipedia.org/wiki/NEDD9
Centrin 1Centrin 1
2006). "The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A". Mol. Cell. 20 (2): 237-49. doi:10.1016 ...
https://en.wikipedia.org/wiki/Centrin_1
CASS4CASS4
The CAS family member NEDD9 has also been shown to interact directly with AURKA (encoding Aurora-A kinase) to regulate cell ... it is possible that CASS4 may similarly interact with aurora-A kinase. CASS4 signaling may contribute to platelet activation ... "The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome". Nature ... These include association with FAK and Src family kinases at focal adhesions to transmit integrin-initiated signals to ...
https://en.wikipedia.org/wiki/CASS4
N-MycN-Myc
"Drugging MYCN through an Allosteric Transition in Aurora Kinase A." Cancer Cell. 26 (3): 414-27. doi:10.1016/j.ccr.2014.07.015 ... N-Myc is also stabilized by aurora A which protects it from degradation. Drugs that target this interaction are under ... development, and are designed to change the conformation of aurora A. Conformational change in Aurora A leads to release of N- ... "Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma". Cancer Cell. 15 (1): 67-78. doi:10.1016/j. ...
https://en.wikipedia.org/wiki/N-Myc
NME1NME1
... has been shown to interact with: Aurora A kinase, CD29 NME3, Protein SET, RAR-related orphan receptor alpha, RAR-related ... "The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1". Nucleic Acids Res. 30 (24): 5465-75 ... Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. It is thought to be a metastasis ... Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) ...
https://en.wikipedia.org/wiki/NME1
Andrea MusacchioAndrea Musacchio
... and for his contributions to the understanding of the role of the kinase Aurora B, Mps1 and Haspin in mitosis. In 2008, the ... Santaguida, S; Vernieri, C; Villa, F; Ciliberto, A; Musacchio, A (Apr 20, 2011). "Evidence that Aurora B is implicated in ... "Mechanism of Aurora B activation by INCENP and inhibition by hesperadin". Molecular Cell. 18 (3): 379-91. doi:10.1016/j.molcel. ... "A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B." (PDF). The Journal of Cell Biology. 199 (2 ...
https://en.wikipedia.org/wiki/Andrea_Musacchio
NUMB (gene)NUMB (gene)
Wirtz-Peitz F, Nishimura T, Knoblich JA (October 2008). "Linking cell cycle to asymmetric division: Aurora-A phosphorylates the ... 1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". ... atypical protein kinase C). In the sensory organ precursor (SOP) cell, the PAR proteins localize to the posterior pole of the ...
https://en.wikipedia.org/wiki/NUMB_(gene)
Shugoshin N terminal protein domainShugoshin N terminal protein domain
Shugoshin is a crucial target of Bub1 kinase that plays a central role in the cohesion of chromosomes during cell division. The ... "Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres". Genes Dev. 21 (4): 420-35. ...
https://en.wikipedia.org/wiki/Shugoshin_N_terminal_protein_domain
ST motifST motif
Aurora, R; Rose GD (1998). "Helix Capping". Protein Science. 7 (1): 21-38. doi:10.1002/pro.5560070103. PMC 2143812. PMID ... SPXX or STXX are frequently found at DNA-binding sites and also that they are recognized as substrates by some protein kinases ...
https://en.wikipedia.org/wiki/ST_motif
Kinesin-like protein KIF11Kinesin-like protein KIF11
Bishop JD, Han Z, Schumacher JM (2005). "The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for ... Rapley J, Nicolas M, Groen A, Regue L, Bertran MT, Caelles C, Avruch J, Roig J (2008). "The NIMA-family kinase Nek6 ... Blangy A, Arnaud L, Nigg EA (1997). "Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor ... "Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase". J Biol Chem. 283 ...
https://en.wikipedia.org/wiki/Kinesin-like_protein_KIF11
Mir-126Mir-126
Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN (2008). "The endothelial- ... suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon ...
https://en.wikipedia.org/wiki/Mir-126
G2-M DNA damage checkpointG2-M DNA damage checkpoint
"Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry". Science. 320 (5883): 1655-1658 ... This loop is further amplified indirectly through the coordinated interaction of the Aurora A kinase and the Bora cofactor. ... pathways which activate the Chk2 and Chk1 kinases, respectively. These kinases act upstream of Cdc25 and Wee1, the direct ... The main rad3 effector is the kinase Chk1, which is required for the G2-M arrest in response to DNA-damaging agents. Chk1 is an ...
https://en.wikipedia.org/wiki/G2-M_DNA_damage_checkpoint
Cell cycle checkpointCell cycle checkpoint
Seki A, Coppinger JA, Jang CY, Yates JR, Fang G (June 2008). "Bora and the kinase Aurora a cooperatively activate the kinase ... These kinases phosphorylate and activate the effector kinases Chk2 and Chk1, respectively, which in turn phosphorylate the ... The G1 phase cyclin-dependent kinase works together with S phase cyclin-dependent kinase targeting p27 for degradation. In turn ... The cell is once more examined for sites of DNA damage or incomplete replication, and the kinases ATR and ATM are recruited to ...
https://en.wikipedia.org/wiki/Cell_cycle_checkpoint
Rosie AlegadoRosie Alegado
Alegado, Rosanna A.; Chin, Chui-Yoke; Monack, Denise M.; Tan, Man-Wah (October 2011). "The two-component sensor kinase KdpD is ... Kahanamoku, Sara; Alegado, Rosie 'Anolani; Kagawa-Viviani, Aurora; Kamelamela, Katie Leimomi; Kamai, Brittany; Walkowicz, ...
https://en.wikipedia.org/wiki/Rosie_Alegado
Centrosome cycleCentrosome cycle
... and Aurora kinases are responsible for this phosphorylation. [21] The phosphorylation of downstream targets of Plks and Aurora ... "Figure 1". Aurora-A: the maker and breaker of spindle poles. Journal of Cell Science. Archived from the original on 11 May 2012 ... "CDK2 cyclin dependent kinase 2 [Homo sapiens (human)]". Gene - NCBI. Retrieved 1 December 2019. Hinchcliffe EH, Li C, Thompson ... The mis-expression of genes such as p53, BRCA1, Mdm2, Aurora-A and survivin causes an increase in the amount of centrosomes ...
https://en.wikipedia.org/wiki/Centrosome_cycle
CytokinesisCytokinesis
The centralspindlin cluster formation is promoted by phosphorylation of MLKP1 by Aurora B, a component of CPC. In short, the ... Petronczki M, Glotzer M, Kraut N, Peters JM (May 2007). "Polo-like kinase 1 triggers the initiation of cytokinesis in human ... Second, RhoA promotes myosin II activation by the kinase ROCK, which activates myosin II directly by phosphorylation of the ...
https://en.wikipedia.org/wiki/Cytokinesis
SurvivinSurvivin
"Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells". J. Biol. Chem. 278 (1): 486-90. doi:10.1074/ ... Survivin has been shown to interact with: Aurora B kinase, CDCA8, Caspase 3, Caspase 7, Diablo homolog and INCENP. GRCh38: ...
https://en.wikipedia.org/wiki/Survivin
SU6656SU6656
Aurora C, Aurora B, CaMKKβ. The inhibition of these kinases in biochemical reactions in vitro does not necessarily indicate ... SU6656 was initially identified as a Src kinase inhibitor by virtue of its ability to reverse an effect that an activated ... SU6656 has been used primarily as a research tool to investigate the function of Src family kinases in cellular signal ... SU6656 is a Src family kinase inhibitor developed by the biotechnology company SUGEN Inc (a subsidiary of Pharmacia) in 2000. ...
https://en.wikipedia.org/wiki/SU6656
CHEK1CHEK1
... role in the spindle checkpoint during mitosis thus interacts with spindle assembly proteins Aurora A kinase and Aurora B kinase ... Checkpoint kinases (Chks) are protein kinases that are involved in cell cycle control. Two checkpoint kinase subtypes have been ... WEE1 kinase and PLK1 are also targeted by Chk1 to induce cell cycle arrest. Phosphorylation of WEE1 kinase inhibits cdk1 which ... Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by ...
https://en.wikipedia.org/wiki/CHEK1
Claire E. EyersClaire E. Eyers
Byrne DP, Vonderach M, Ferries S, Brownridge PJ, Eyers CE, Eyers PA (2016). "cAMP-dependent protein kinase (PKA) complexes ... "Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by ... protein kinase complexes and glycan conformation, and several highly-accessed reviews[citation needed] on the subject of ion ... at the University of Dundee where she was awarded a PhD in 2002 for her work on stress-activated protein kinases with Sir ...
https://en.wikipedia.org/wiki/Claire_E._Eyers
TelophaseTelophase
Aurora B kinase, and kinesin-8". The Journal of Cell Biology. 191 (4): 795-808. doi:10.1083/jcb.201006028. PMC 2983061. PMID ... The phosphorylation of the protein targets of M-Cdks (Mitotic Cyclin-dependent Kinases) drives spindle assembly, chromosome ... Telophase is primarily driven by the dephosphorylation of mitotic cyclin-dependent kinase (Cdk) substrates. ... microtubule-stabilizer-specific kinases, and plus-end directed microtubule depolymerases, respectively. These effectors are ...
https://en.wikipedia.org/wiki/Telophase
David GloverDavid Glover
This led to genetic studies that allowed him to discover and name the Polo and Aurora protein kinases, required for the ... In Cambridge he discovered the second main Aurora B kinase required for cells to progress through metaphase and used genetic ... Over the past decade he has uncovered the major steps of centriole duplication by demonstrating that Polo-like-kinase 4 (Plk4) ... Remarkably, the localisation and function of Polo kinase at the centrosome, the kinetochore and the central spindle in ...
https://en.wikipedia.org/wiki/David_Glover
Bill EarnshawBill Earnshaw
He discovered the "chromosomal passenger complex" of INCENP, Aurora B kinase, Survivin and Borealin - a major regulator of ...
https://en.wikipedia.org/wiki/Bill_Earnshaw
JUB (gene)JUB (gene)
Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment. JUB (gene) has been ... Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H (2003). "Aurora-A and an interacting ... Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2 ... Protein Ajuba Influences Interleukin-1-Induced NF-κB Activation by Affecting the Assembly and Activity of the Protein Kinase Cζ ...
https://en.wikipedia.org/wiki/JUB_(gene)
Bcr-Abl tyrosine-kinase inhibitorBcr-Abl tyrosine-kinase inhibitor
Unlike other T315I targeting inhibitors in development, ponatinib does not target Aurora kinases, which clearly distinguishes ... At first it was believed that bosutinib was a selective Src kinase inhibitor but now it is known that its kinase inhibition ... Since dasatinib is an inhibitor of Src family kinases, it can overcome resistance due to Src family kinase activation. Because ... particularly the Src family kinases. The Src family kinases have been implicated in Bcr-Abl signaling and mediate imatinib ...
https://en.wikipedia.org/wiki/Bcr-Abl_tyrosine-kinase_inhibitor
IPO8IPO8
"Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation". Nature Cell Biology. ... "14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective ...
https://en.wikipedia.org/wiki/IPO8
Aurora BiosciencesAurora Biosciences
... wanted to apply Aurora's assay expertise to its programs in kinase inhibitors and caspase inhibitors, and wanted access to ... which created Aurora Discovery from it. Aurora Discovery eventually changed its name to Aurora Biotechnologies, and in 2009 was ... In 2001, Aurora was acquired by Vertex Pharmaceuticals for $592 million in stock. Vertex wanted access to Aurora's insight into ... Vertex retained Aurora's drug discovery facility and staff in San Diego; ivacaftor was discovered there in 2005. "Aurora ...
https://en.wikipedia.org/wiki/Aurora_Biosciences
Garikapati Narahari SastryGarikapati Narahari Sastry
Badrinarayan, Preethi; Sastry, G. Narahari (2014). "Specificity Rendering 'Hot-Spots' for Aurora Kinase Inhibitor Design: The ... Badrinarayan, Preethi; Sastry, G. Narahari (2011). "Sequence, Structure, and Active Site Analyses of p38 MAP Kinase: Exploiting ...
https://en.wikipedia.org/wiki/Garikapati_Narahari_Sastry
SEPTIN1SEPTIN1
... a new interaction partner for human serine/threonine kinase aurora-B". Biochemical and Biophysical Research Communications. 336 ...
https://en.wikipedia.org/wiki/SEPTIN1
Aurora libraries. Aurora A-B Kinases Targeted LibraryAurora libraries. Aurora A-B Kinases Targeted Library
Aurora A-B Kinases Library is a set of small-molecule Aurora kinase inhibitors. Overexpression of Aurora kinases has been ... ZIP Aurora libraries. Aurora A-B Kinases Targeted Library 9,342 compounds PDF Aurora libraries. Aurora A-B Kinases Targeted ... Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), ... Besides regulating mitosis, Aurora kinases have been implicated in regulating meiosis. The deletion of Aurora kinases could ...
https://www.chemdiv.com/catalog/focused-and-targeted-libraries/aurora-a-b-kinases-library/
Aurora kinase (Aur) family | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGYAurora kinase (Aur) family | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY
Aurora kinase (Aur) family in the IUPHAR/BPS Guide to PHARMACOLOGY. ... ARK1 , AurA , Aurora 2 , Aurora family kinase 1 , ratAurA , serine/threonine kinase 15 , serine/threonine kinase 6 , STK15 , ... Aurora kinases A and B are widely expressed in dividing cells, whereas Aurora kinase C expression appears to be restricted to ... 2010) Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer, 10 (12): 825-41. [PMID: ...
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=557
Aurora A kinase activation: Different means to different ends | Journal of Cell Biology | Rockefeller University PressAurora A kinase activation: Different means to different ends | Journal of Cell Biology | Rockefeller University Press
review the different activation mechanisms of the Aurora A kinase during mitotic entry and progression. ... Aurora B kinase, Polo-like kinase 1 (Plk1), and Cyclin-dependent kinase 1 (Cdk1)/Cyclin A/B complexes. Their precise and ... Aurora A kinase activation: Different means to different ends Nicolas Tavernier, Nicolas Tavernier ... Aurora A is a serine/threonine kinase essential for mitotic entry and spindle assembly. Recent molecular studies have revealed ...
https://rupress.org/jcb/article-standard/220/9/e202106128/212490/Aurora-A-kinase-activation-Different-means-to
Human AURKB (Aurora Kinase B) ELISA Kit - AFSBio Inc.Human AURKB (Aurora Kinase B) ELISA Kit - AFSBio Inc.
Serine/Threonine Kinase 12; Aurora-1; Aurora-and IPL1-like midbody-associated protein 1; Aurora/IPL1-related kinase 2 Species: ... Aurora-1; Aurora-and IPL1-like midbody-associated protein 1; Aurora/IPL1-related kinase 2 ... The concentration of Aurora Kinase B(AURKB) in the samples is then determined by comparing the OD of the samples to the ... The microtiter plate provided in this kit has been pre-coated with an antibody specific to Aurora Kinase B(AURKB). Standards or ...
https://afsbio.com/products/human-aurkb-aurora-kinase-b-elisa-kit
High expression of aurora kinase B predicts poor prognosis in hepatocellular carcinoma after curative surgery and its effects...High expression of aurora kinase B predicts poor prognosis in hepatocellular carcinoma after curative surgery and its effects...
High expression of aurora kinase B predicts poor prognosis in hepatocellular carcinoma after curative surgery and its effects ...
https://atm.amegroups.com/article/view/104338/pdf
Aurora B kinase is the downstream target of ATR - Oregon Health & Science UniversityAurora B kinase is the downstream target of ATR - Oregon Health & Science University
Aurora B kinase is thought to be responsible for the phosphorylation of H-3. Recent results from the Thayer lab have shown that ... Aurora B kinase is the downstream target of ATR. *Chang, Bill (PI) ... Therefore, I hypothesize that inhibition of Aurora B, either by inhibition of kinase activity or inhibition of recruitment to ... The objective is to characterize the link between DRT/DMC, the replication checkpoint, and Aurora B kinase. ...
https://ohsu.pure.elsevier.com/en/projects/aurora-b-kinase-is-the-downstream-target-of-atr
October | 2022 | Aurora kinase B
Aurora kinase B. Aurora kinase B was identified in humans by a polymerase chain reaction screen for kinases that are ... men and women and those that havent examined pertaining to Human immunodeficiency virus.The actual ICI 46474 mw multi-kinase ...
https://aurorakinaseb.com/2022/10
ProViz - Aurora kinase A - AURKA - O14965ProViz - Aurora kinase A - AURKA - O14965
ProViz is an interactive protein exploration tool, which searches several databases for information about a given query protein. Data relevant to the protein like an alignment of homologues, linear motifs, post translational modifications, domains, secondary structure, sequence variations and others are graphically represented relative to their position in the protein.
http://slim.icr.ac.uk/proviz/proviz.php?uniprot_acc=O14965&alignment=GeneTree
Aurora Kinase | Cell Cycle|Epigenetics| CSNpharmAurora Kinase | Cell Cycle|Epigenetics| CSNpharm
Three Aurora kinases have been identified in mammalian cells to date, Aurora A, Aurora B, Aurora C. Besides being implicated as ... Aurora kinase helps the dividing cell dispense its genetic materials to its daughter cells. Defects in this segregation can ... mitotic regulators, these three kinases have generated significant interest in the cancer research field due to their elevated ... Aurora kinases are serine/threonine kinases that are essential for cell proliferation. ...
https://www.csnpharm.com/aurora-kinase.html
Aurora Kinase compound (inhibitors, antagonists)-ProbeChem.comAurora Kinase compound (inhibitors, antagonists)-ProbeChem.com
... potent and selective Aurora A, Aurora B, Aurora C inhibitor. ... Aurora Kinase Request The Product List ofAurora Kinase Aurora ... Aurora Kinase compound (inhibitors, antagonists, inducers) with high quality and purity, chemical tool in various assays for ... F114 is a novel, first-in-class, dual aurora and lim kinase inhibitor with IC50 of 72 nM and 137 nM against Aurora-A and Limk1 ... PF-03814735 is a potent, orally bioavailable, reversible inhibitor of both Aurora A and Aurora B kinases with IC50 values of ...
http://www.probechem.com/target_AuroraKinase.html
IMSEAR at SEARO: Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase
The Aurora kinases represent a group of serine/threonine kinases which are crucial regulators of mitosis. DysregulatedAurora ... Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase. Authors: Bose, Arnab. Sudevan, Surabhi ... Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase. Journal of Biosciences. 2019 Dec; 44(6 ... kinase B (AurkB) expression, stemming from genomic amplification, increased gene transcription or overexpressionof its ...
https://imsear.searo.who.int/handle/123456789/214214
June 2016 - Page 7 - Polo-Like Kinases and Aurora Kinases in Cancer TherapyJune 2016 - Page 7 - Polo-Like Kinases and Aurora Kinases in Cancer Therapy
Lectin-like oxidized low-density lipoprotein receptor (LOX-1) is really a scavenger receptor that binds oxidized low-density lipoprotein (OxLDL) and has a role in atherosclerosis development. both control and test slides. 2.8 Chaperonin-containing TCP-1 (CCT) complex purification CCT was purified from bovine testes according to previously established procedures and the integrity of the oligomeric CCT complex was confirmed by using single-particle cryoelectron microscopy BCH [32-33]. The final purified protein concentration was determined by using the Bradford assay with BSA standards (Pierce) and substrate folding activity of the CCT complex was assessed with a luciferase refolding assay as previously described [34]. 2.9 Direct binding assay NeutrAvidin agarose beads (100 μl of 50% slurry Thermo Scientific) were washed in CCT lysis buffer which comprised 25 mM HEPES (pH 7.4) 100 mM KCl 5 mM MgCl2 10 glycerol 0.1% Triton X-100 20 mM EDTA 0.1% v/v Tween-20 and protease inhibitors (Roche). Then ...
http://www.technumber.com/2016/06/page/7/
June 2022 - Structure-based characterization of novel Aurora Kinase inhibitors
There was marked increased in creatine kinase (11,960?U/L in the beginning and 24,240?U/L after 1 day) and lactate ... There was marked increased in creatine kinase (11,960?U/L initially and 24,240?U/L after 1 day) and lactate dehydrogenase ... There was marked increased in creatine kinase (11,960?U/L initially and 24,240?U/L after 1 day) and lactate dehydrogenase ...
https://nipponkaigi-tokyo.com/2022/06/
A phase i study of MK-5108, an oral aurora a kinase inhibitor, administered both as monotherapy and in combination with...A phase i study of MK-5108, an oral aurora a kinase inhibitor, administered both as monotherapy and in combination with...
Dive into the research topics of A phase i study of MK-5108, an oral aurora a kinase inhibitor, administered both as ... T1 - A phase i study of MK-5108, an oral aurora a kinase inhibitor, administered both as monotherapy and in combination with ... N2 - Background MK-5108 is a potent/highly selective Aurora A kinase inhibitor. Methods A randomized Phase I study of MK-5108, ... AB - Background MK-5108 is a potent/highly selective Aurora A kinase inhibitor. Methods A randomized Phase I study of MK-5108, ...
https://profiles.wustl.edu/en/publications/a-phase-i-study-of-mk-5108-an-oral-aurora-a-kinase-inhibitor-admi
The Role of Aurora Kinase Inhibitors in hematologic disorders - Aurora Kinase InhibitorThe Role of Aurora Kinase Inhibitors in hematologic disorders - Aurora Kinase Inhibitor
2022 - The Role of Aurora Kinase Inhibitors in hematologic disorders , All rights reserved ...
http://ubatubasat.com
MedlinePlus: GenesMedlinePlus: Genes
AURKC: aurora kinase C. *AVP: arginine vasopressin. *AVPR2: arginine vasopressin receptor 2 ...
https://medlineplus.gov/genetics/gene
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...
Aurora kinase A * Carcinoembryonic antigen-related cell adhesion molecule (CEACAM1) * Epigenetic markers ... Fibroblast growth factor receptor 3 (FGFR3) belongs to a family of tyrosine kinase receptors and is encoded by the FGFR3 gene. ...
https://www.medscape.com/answers/1953022-186640/what-is-the-role-of-urinary-biomarkers-in-bladder-cancer-surveillance
Tension directly stabilizes reconstituted kinetochore-microtubule attachments | NatureTension directly stabilizes reconstituted kinetochore-microtubule attachments | Nature
... through a catch bond-like mechanism that does not require Aurora B7,8,9,10. On the basis of these findings, we propose that ... Aurora B4,5. However, a complete mechanistic understanding of the role of tension requires reconstitution of kinetochore- ... by suppressing the destabilizing activity of a kinase, ... Tension can directly suppress Aurora B kinase-triggered release ... Tension can directly suppress Aurora B kinase-triggered release of kinetochore-microtubule attachments *Anna K. de Regt ...
https://www.nature.com/articles/nature09594?error=cookies_not_supported&code=0da49d6b-0032-47bb-94fe-b1254e16d5c6
Phosphorylation of Merlin by Aurora A kinase appears necessary for mitotic progression | Institut CuriePhosphorylation of Merlin by Aurora A kinase appears necessary for mitotic progression | Institut Curie
Phosphorylation of Merlin by Aurora A kinase appears necessary for mitotic progression. 1 Aug, 2019. ...
https://institut-curie.org/publications/phosphorylation-merlin-aurora-kinase-appears-necessary-mitotic-progression
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...
Aurora kinase A * Carcinoembryonic antigen-related cell adhesion molecule (CEACAM1) * Epigenetic markers ... Fibroblast growth factor receptor 3 (FGFR3) belongs to a family of tyrosine kinase receptors and is encoded by the FGFR3 gene. ...
http://emedicine.medscape.com/article/1953022-overview
Inactivation of Aurora kinases and Cyclin-dependent kinases 4/6 allows by Vural Tagal, Uttam K. Tambar et al."Inactivation of Aurora kinases and Cyclin-dependent kinases 4/6 allows" by Vural Tagal, Uttam K. Tambar et al.
Inactivation of Aurora kinases and Cyclin-dependent kinases 4/6 allows cancers to adopt an endoreplication and form polyploid/ ... "Inactivation of Aurora kinases and Cyclin-dependent kinases 4/6 allows cancers to adopt an endoreplication and form polyploid/ ...
https://openworks.mdanderson.org/leading-edge/45/
AURORA KINASE A and related downstream molecules: A potential network for cancer therapy. | Adv Protein Chem Struct Biol;134:...AURORA KINASE A and related downstream molecules: A potential network for cancer therapy. | Adv Protein Chem Struct Biol;134:...
Aurora-A kinase (AURKA) belongs to the serine/threonine kinase family specific to cell division. In normal cells, activation of ... AURORA KINASE A and related downstream molecules: A potential network for cancer therapy. ... AURORA KINASE A and related downstream molecules: A potential network for cancer therapy. ... Aurora Quinase A; Carcinogênese; Humanos; Ciclo Celular; Proliferação de Células; Inibidores de Proteínas Quinases ...
https://pesquisa.bvsalud.org/portal/resource/pt/mdl-36858732
MicroRNA let-7b regulates genomic balance by targeting Aurora B kinase - Fingerprint - VTTs Research Information PortalMicroRNA let-7b regulates genomic balance by targeting Aurora B kinase - Fingerprint - VTT's Research Information Portal
MicroRNA let-7b regulates genomic balance by targeting Aurora B kinase. Jenni Heidi Eveliina Mäki-Jouppila, Sofia Pruikkonen, ... Dive into the research topics of MicroRNA let-7b regulates genomic balance by targeting Aurora B kinase. Together they form a ...
https://cris.vtt.fi/en/publications/microrna-let-7b-regulates-genomic-balance-by-targeting-aurora-b-k/fingerprints/
Ras-Driven Transcriptome Analysis Identifies Aurora Kinase ......Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as...Ras-Driven Transcriptome Analysis Identifies Aurora Kinase ......Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as...
Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant... ... Download Ras-Driven Transcriptome Analysis Identifies Aurora Kinase ...... ... Ras-Driven Transcriptome Analysis Identifies Aurora Kinase ......Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as ... a serine/threonine kinase, is a member of the mitogen activated protein kinase kinase kinase ...
https://fdocuments.in/download/ras-driven-transcriptome-analysis-identiies-aurora-kinase-ras-driven-transcriptome
CHIR-124 405168-58-3 was the first to combine the seen an Aurora kinase inhibition | Microrna Inhibitors
CHIR-124 405168-58-3 was the first to combine the seen an Aurora kinase inhibition. Posted on July 27, 2012. by mirn0190 ... MLN8237 MLN8237 MLN8054 2.1.4 to share structural homology, but has four times the power of the inhibition of Aurora kinase A ... 6 This study was the first to combine the seen an Aurora kinase inhibition, and senescence, a classic effect with antimitotic ... evident that key Drowsiness and liver toxicity escalation t limited to the level necessary to adequately inhibit Aurora kinase ...
https://mirnainhibitors.com/chir-124-405168-58-3-was-the-first-to-combine-the-seen-an-aurora-kinase-inhibition
Therapeutic Options Against BCR-ABL1 T315I-Positive Chronic Myelogenous Leukemia | Clinical Cancer Research | American...Therapeutic Options Against BCR-ABL1 T315I-Positive Chronic Myelogenous Leukemia | Clinical Cancer Research | American...
Dual Aurora/ABL kinase inhibitors. The human Aurora proteins (A, B, and C) are serine/threonine kinases that regulate different ... Other Aurora kinase inhibitors with anti-T315I activity. VE-465 is an Aurora kinase inhibitor structurally related to MK-0457 ... Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer ... AT9283, an inhibitor of Aurora A, Aurora B, JAK2, JAK3, and BCR-ABL T315I kinases (IC50 , 5 nmol/L in all case), is undergoing ...
https://aacrjournals.org/clincancerres/article/14/14/4392/72722/Therapeutic-Options-Against-BCR-ABL1-T315I
6R4B: Aurora-A in complex with shape-diverse fragment 566R4B: Aurora-A in complex with shape-diverse fragment 56
Aurora kinase A(6~{S})-6-[2,4-bis(fluoranyl)phenyl]-~{N},~{N},4-trimethyl-2-oxidanylidene-5,6-dihydro-1~{H}-pyrimidine-5- ... Aurora Kinase a. (Gene symbol: AURKA). Chemicals and Non-standard biopolymers (8 molecules) ...
https://www.ncbi.nlm.nih.gov/Structure/pdb/6R4B
Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B...Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B...
2015) Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B ... Aurora Kinase B, Cell Aging, Cell Division, Cell Line, Cell Nucleus, Chromosome Segregation, Cytokinesis, HeLa Cells, High- ... Downstream analyses show that all of the compounds that induce tetraploid senescence inhibit Aurora kinase B (AURKB). AURKB is ... Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B ...
https://openaccess.sgul.ac.uk/id/eprint/108430/
PDB 5DNR | Chain AURORA A KINASE IN COMPLEX WITH ATP IN SPACE GROUP P41212 | 5DNR A | 3D Structure | canSARSPDB 5DNR | Chain AURORA A KINASE IN COMPLEX WITH ATP IN SPACE GROUP P41212 | 5DNR A | 3D Structure | canSARS
AURORA A KINASE IN COMPLEX WITH ATP IN SPACE GROUP P41212 - 5DNR , canSARS ...
https://corona-2.cansar.icr.ac.uk/structure/5DNR/3d/5DNR_A
Our new article Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis is published in Journal of...Our new article "Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis" is published in Journal of...
"Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis" is published in Journal of Proteome Research. ... HomeOur new article "Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis" is published in Journal of ... Our new article "Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis" is published in Journal of ... "Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis" is published in Journal of Proteome Research. ...
https://cell-proteomics.ku.edu.tr/news/our-new-article-phosphoproteomic-analysis-of-aurora-kinase-inhibition-in-monopolar-cytokinesis-is-published-in-journal-of-proteome-research/
InhibitorInhibitionSerineInhibitorsAURKAMitosisProtein kinaseMammalianAURKBVitroPhosphatidylinositol 3-kinaMitotic kinasePhosphorylationOncogenicPathwaysAURKCCyclinInhibitApoptosisVivoSpindle assemblyKinetochoreTherapeuticComplexesMutationsRecombinantGeneCompoundsYeast
Inhibitor27
  • 2006) 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile. (guidetopharmacology.org)
  • 2004) VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. (guidetopharmacology.org)
  • Tripolin A ((E)-Tripolin A) is a specific non-ATP competitive Aurora A kinase inhibitor, with IC50 values of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively[1]. (csnpharm.com)
  • Tozasertib is the inhibitor of Aurora-A, -B, -C kinases with Ki values of 0.6, 18, 4.6 nM respectively. (csnpharm.com)
  • TC-A2317 HCl is an Aurora kinase A inhibitor. (csnpharm.com)
  • SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. (csnpharm.com)
  • SP-96 is a highly selective and non-ATP-competitive Aurora A/B inhibitor with IC50 values of 0.316nM 18.975 nM for Aurora A and Aurora B, respectively. (csnpharm.com)
  • NU6140 is a selective CDK2 inhibitor with IC50 value of 0.94μM, as well as potently inhibits Aurora kinase A/B with IC50 values of 0.035 and 0.067μM, respectively. (csnpharm.com)
  • Derrone, a natural product isolated and purified from the herbs of Cudrania tricuspidata, may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens, and is an Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 tumor spheroids. (csnpharm.com)
  • DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases, including Aurora-A, FLT3, CSF1R, MET, etc. (csnpharm.com)
  • Danusertib is a pyrrolo-pyrazole and small molecule Aurora kinases inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. (csnpharm.com)
  • CD532 is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. (csnpharm.com)
  • Cenisertib (AS 703569;R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM). (probechem.com)
  • Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively. (probechem.com)
  • PF-03814735 is a potent, orally bioavailable, reversible inhibitor of both Aurora A and Aurora B kinases with IC50 values of 0.8 and 5 nM, respectively. (probechem.com)
  • PHA-680626 is a kinase inhibitor exhibiting strong inhibitory activity on both Bcr-Abl and Aurora kinases, also inhibits the formation of the Aurora-A/N-Myc complex. (probechem.com)
  • Tinengotinib (TT-00420) is a spectrum-selective multikinase inhibitor that targets cell proliferation, angiogenesis, and immunomodulatory pathways by inhibiting Aurora A/B and JAK involved in cytokine signalling, and RTKs involved in angiogenesis (FGFRs and VEGFRs). (probechem.com)
  • F114 is a novel, first-in-class, dual aurora and lim kinase inhibitor with IC50 of 72 nM and 137 nM against Aurora-A and Limk1, respectively, F114 inhibits GBM proliferation and invasion. (probechem.com)
  • TAS-119 (TAS119) is a potent, selective, orally active inhibitor of Aurora A with IC50 of 1 nM. (probechem.com)
  • Background MK-5108 is a potent/highly selective Aurora A kinase inhibitor. (wustl.edu)
  • We characterize the screen using a focused tool compound kinase inhibitor library. (sgul.ac.uk)
  • A phase Ib study of investigational pan-RAF kinase inhibitor MLN2480 plus investigational TORC1/2 inhibitor MLN0128, investigational Aurora A kinase inhibitor alisertib (MLN8237), or paclitaxel in patients (pts) with advanced solid tumors. (ox.ac.uk)
  • Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 studies for the treatment of lung cancer and nasopharyngeal cancer and in a Phase 1 trial in combination with sapacitabine. (nbcnews.com)
  • CYC116, an Aurora kinase and VEGFR2 inhibitor, is in a Phase 1 trial in patients with solid tumors. (nbcnews.com)
  • mTOR kinase inhibitor AZD2014 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. (biochempartner.com)
  • CHIR-99021 is a glycogen synthase kinase 3 beta inhibitor that has antiproliferative activity in vitro and in vivo. (dcchemicals.com)
  • CHIR-99021 is a GSK-3α/β inhibitor with an IC50 of 10 and 6.7 nM，showing 500-fold selectivity over its closest homologs CDC2 and ERK2, as well as other protein kinases. (dcchemicals.com)
Inhibition10
  • And a growing number of studies have demonstrated that inhibition of Aurora kinases could potentiate the effect of chemotherapies. (chemdiv.com)
  • Therefore, I hypothesize that inhibition of Aurora B, either by inhibition of kinase activity or inhibition of recruitment to the chromosome, plays a direct role in the DMC phenotype. (elsevier.com)
  • 6 This study was the first to combine the seen an Aurora kinase inhibition, and senescence, a classic effect with antimitotic agents. (mirnainhibitors.com)
  • MLN8237 MLN8237 MLN8054 2.1.4 to share structural homology, but has four times the power of the inhibition of Aurora kinase A and reduced tendency for the key Can cause drowsiness. (mirnainhibitors.com)
  • Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. (sgul.ac.uk)
  • Our new article "Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis" is published in Journal of Proteome Research. (ku.edu.tr)
  • Here, we investigated the effects of glycogen synthase kinase 3 (GSK3) inhibition via lithium chloride (LiCl) treatment on SERCA uncoupling in skeletal muscle and UCP1 expression in adipose. (jbc.org)
  • ALS concentration-dependently induced autophagy in PANC-1 and BxPC-3 cells, which may be attributed to the inhibition of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR), p38 mitogen-activated protein kinase (p38 MAPK), and extracellular signal-regulated kinases 1 and 2 (Erk1/2) but activation of 5'-AMP-dependent kinase signaling pathways. (dovepress.com)
  • Schubert A, Koziol U, Cailliau K, Vanderstraete M, Dissous C, Brehm K (2014) Targeting Echinococcus multilocularis Stem Cells by Inhibition of the Polo-Like Kinase EmPlk1. (plos.org)
  • no significant inhibition on 26 other kinases. (dcchemicals.com)
Serine7
  • Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via regulating mitosis especially the process of chromosomal segregation. (chemdiv.com)
  • Aurora A is a serine/threonine kinase essential for mitotic entry and spindle assembly. (rupress.org)
  • The Aurora kinases represent a group of serine/threonine kinases which are crucial regulators of mitosis. (who.int)
  • Aurora-A kinase ( AURKA ) belongs to the serine / threonine kinase family specific to cell division . (bvsalud.org)
  • Aurora A is a cytoplasmic serine/threonine kinase that is critical in transitioning cells through mitosis and meiosis. (novusbio.com)
  • A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS . (bvsalud.org)
  • mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/Akt/mTOR signaling pathway. (biochempartner.com)
Inhibitors9
  • For the past decades, a series of Aurora kinases inhibitors (AKIs) developed effectively repress the progression and growth of many cancers both in vivo and in vitro, suggesting that Aurora kinases could be a novel therapeutic target. (chemdiv.com)
  • Currently, more than 100 crystallographic complexes obtained for various small-molecule Aurora kinase inhibitors are available within PDB databank. (chemdiv.com)
  • Representative compounds from ChemDiv's library have demonstrated similar binding mode compared to reported Aurora kinase inhibitors. (chemdiv.com)
  • Their importance in the mitotic cycle has driven the development of Aurora kinase inhibitors as therapeutic antimitotic agents for both adult and childhood malignancies. (guidetopharmacology.org)
  • 2009) A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem , 52 (10): 3300-7. (guidetopharmacology.org)
  • 2010) Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. (guidetopharmacology.org)
  • Mutations within the kinase domain of BCR-ABL1 constitute the most frequent mechanism of resistance in patients with chronic myelogenous leukemia treated with imatinib or the second generation tyrosine kinase inhibitors nilotinib and dasatinib. (aacrjournals.org)
  • Of note, different mutations confer varying degrees of insensitivity to imatinib and other tyrosine kinase inhibitors (TKI). (aacrjournals.org)
  • Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase. (mpg.de)
AURKA2
  • Pivotal protein kinases responsible for the massive increase in protein phosphorylation as cells transit into mitosis include Aurora A kinase (AURKA), Aurora B kinase, Polo-like kinase 1 (Plk1), and Cyclin-dependent kinase 1 (Cdk1)/Cyclin A/B complexes. (rupress.org)
  • AURKA phosphorylates its substrates , including oncoproteins , transcriptional factors, tumor suppressor proteins , or other kinases central to various oncogenic signaling pathways critical to cancer . (bvsalud.org)
Mitosis6
  • Besides regulating mitosis, Aurora kinases have been implicated in regulating meiosis. (chemdiv.com)
  • The three mammalian Aurora kinases (A, B and C) play essential roles cell division, by regulating mitosis and the cell cycle. (guidetopharmacology.org)
  • 6. Fu J, Bian M, Jiang Q, Zhang C. (2007) Roles of Aurora kinases in mitosis and tumorigenesis. (guidetopharmacology.org)
  • We herein describe the characterization of EmPlk1, encoded by the gene emplk1 , which displays significant homologies to members of the Plk1 sub-family of Polo-like kinases that regulate mitosis in eukaryotic cells. (plos.org)
  • Familia de serina-treonina cinasas implicadas en la regulación de la MITOSIS. (bvsalud.org)
  • CDK11p58 kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis. (univ-rennes.fr)
Protein kinase1
  • Protein kinase C epsilon is important in modulating organic-dust-induced airway inflammation. (cdc.gov)
Mammalian2
  • Unanchored dendrogram of mammalian protein kinases. (kinase.com)
  • Anchored dendrogram of mammalian protein kinases. (kinase.com)
AURKB7
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Aurora Kinase B(AURKB). (afsbio.com)
  • Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Aurora Kinase B(AURKB). (afsbio.com)
  • After TMB substrate solution is added, only those wells that contain Aurora Kinase B(AURKB), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (afsbio.com)
  • The concentration of Aurora Kinase B(AURKB) in the samples is then determined by comparing the OD of the samples to the standard curve. (afsbio.com)
  • DysregulatedAurora kinase B (AurkB) expression, stemming from genomic amplification, increased gene transcription or overexpressionof its allosteric activators, is capable of initiating and sustaining malignant phenotypes. (who.int)
  • The haploinsufficient tumor suppressor Tip60 acetylates two highly conserved lysine residues within the kinasedomain of AurkB which not only impinges the protein stability but also its kinase activity. (who.int)
  • Downstream analyses show that all of the compounds that induce tetraploid senescence inhibit Aurora kinase B (AURKB). (sgul.ac.uk)
Vitro3
  • CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. (csnpharm.com)
  • Next, Mid1p "N-term" and "Middle" domains were mapped to yield six potential phospho-sites (S167, S328, S331, S332, S523 and S531), which were utilized to confirm the in vitro phosphorylation by the aurora kinase Ark1p. (bl.uk)
  • CHIR 99021 is a small organic molecule that inhibits GSK3α and GSK3β by competing for their ATP-binding sites.In vitro kinase assays reveal that CHIR 99021 specifically inhibits GSK3β (IC50=~5 nM) and GSK3α (IC50=~10 nM), with little effect on other kinases[2]. (dcchemicals.com)
Phosphatidylinositol 3-kina1
  • Many well-characterized mitogens [e.g. insulin-like growth factor (IGF),platelet-derived growth factor] signal through receptor tyrosine kinases(RTKs) that lead to activation of the Ras-MAPK and phosphatidylinositol-3-kinase (PI3K) pathways( Marshall, 1995 ). (biologists.com)
Mitotic kinase2
  • Here, we report a novel interaction between the mitotic kinase, Aurora A, and the glycolytic enzyme, pyruvate kinase M2 (PKM2), in the interphase of the cell cycle. (jbc.org)
  • A GFP fusion with the mitotic kinase Aurora-A labels centrosomes during the division of an SOP cell. (oeaw.ac.at)
Phosphorylation4
  • Recent molecular studies have revealed the existence of multiple, distinct mechanisms of Aurora A activation, each occurring at specific subcellular locations, optimized for cellular context, and primed by signaling events including phosphorylation and oxidation. (rupress.org)
  • Aurora B kinase is thought to be responsible for the phosphorylation of H-3. (elsevier.com)
  • We found Aurora A-mediated phosphorylation of PKM2 at threonine 45. (jbc.org)
  • Aurora A-dependent CENP-A phosphorylation at inner centromeres protects bioriented chromosomes against cohesion fatigue. (univ-rennes.fr)
Oncogenic1
  • Bose Arnab, Sudevan Surabhi, Rao Vinay J, Shima Hiroki, Trivedi Arun Kumar, Igarashi Kazuhiko, Kundu Tapas K. Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase. (who.int)
Pathways3
  • To expedite the identification of strategies to override the resistance imposed by the T315I mutation, several strategies have been pursued, including the exploitation of BCR-ABL1 kinase sites distant from the ATP-binding pocket to cripple the kinase activity of the enzyme and inhibiting signaling pathways downstream from BCR-ABL1. (aacrjournals.org)
  • The marked dependence of BCR-ABL1 -positive cells on BCR-ABL1 kinase spurred the design of agents aiming at blocking the activity of this enzyme and its downstream signaling pathways. (aacrjournals.org)
  • Neuronal precursor cells in the developing cerebellum require activity of the sonic hedgehog (Shh) and phosphoinositide-3-kinase (PI3K) pathways for growth and survival. (biologists.com)
AURKC1
  • Function of aurora kinase C (AURKC) in human reproduction]. (cdc.gov)
Cyclin3
  • Inactivation of Aurora kinases and Cyclin-dependent kinases 4/6 allows" by Vural Tagal, Uttam K. Tambar et al. (mdanderson.org)
  • ALS remarkably arrested PANC-1 and BxPC-3 cells in G 2 /M phase via regulating the expression of cyclin-dependent kinases 1 and 2, cyclin B1, cyclin D1, p21 Waf1/Cip1, p27 Kip1, and p53. (dovepress.com)
  • The potential genes underlying the differential effects of G‑SCs and P‑SCs on bone invasion in OSCC were evaluated using a microarray, which indicated that cyclin‑dependent kinase 1, insulin, aurora kinase A, cyclin B1 and DNA topoisomerase II alpha underlaid these differential effects. (spandidos-publications.com)
Inhibit1
  • It was evident that key Drowsiness and liver toxicity escalation t limited to the level necessary to adequately inhibit Aurora kinase A. Based on these results, the development of MLN8054 MLN8237 abandoned in favor. (mirnainhibitors.com)
Apoptosis3
  • DUOXA1 knockdown (using a DUOXA1 shRNA construct) resulted in enhanced differentiation compared to cells subjected to a control shRNA and subjecting DUOXA1 overexpressing cells to siRNAs targeting DUOX1 or apoptosis signal-regulating kinase 1 (ASK1) rescued the PRKCA phenotype. (researchensemble.com)
  • We further show that a common regulator of apoptosis apoptosis signal-regulating kinase 1 (ASK1) is usually a downstream target of Balaglitazone DUOXA1-mediated H2O2 production and that knockdown of either DUOX1 or ASK1 rescues the DUOXA1 overexpression phenotype. (researchensemble.com)
  • An intracellular-signaling kinase that plays a role in regulating APOPTOSIS . (nih.gov)
Vivo1
  • BCR-ABL1 kinase has been shown to play a pivotal role in vivo in the development and maintenance of BCR-ABL1 -mediated leukemogenesis in several experimental models ( 1 - 3 ). (aacrjournals.org)
Spindle assembly1
  • 4. Ducat D, Zheng Y. (2004) Aurora kinases in spindle assembly and chromosome segregation. (guidetopharmacology.org)
Kinetochore1
  • The aurora B kinase promotes inner and outer kinetochore interactions in budding yeast. (ox.ac.uk)
Therapeutic1
  • Journal Article] A novel therapeutic combination targeting sequentially Aurora B and Bcl-xL in hepatocellular carcinoma. (nii.ac.jp)
Complexes1
  • Crystal structures of active Src kinase domain complexes. (mpg.de)
Mutations3
  • These results notwithstanding, a subset of patients receiving imatinib therapy develop resistance to imatinib, which are frequently associated with single-point mutations within the kinase domain of BCR-ABL1 . (aacrjournals.org)
  • More than 100 different ABL kinase point mutations have been reported in patients with imatinib-resistant CML ( 8 - 13 ). (aacrjournals.org)
  • These mutations impair imatinib binding either by changing the identity of residues with which imatinib makes direct contact within the kinase domain (e.g. (aacrjournals.org)
Recombinant1
  • A recombinant protein made to an N-terminal region of the human Aurora A protein (within residues 50-200). (novusbio.com)
Gene2
  • Overexpression or gene amplification of Aurora kinases has been clarified in a number of cancers. (chemdiv.com)
  • Dec 07): An updated table (Excel) includes Gene IDs, refseq accessions, HGNC names and improved sequences for some kinases. (kinase.com)
Compounds1
  • ChemDiv's Aurora A-B Kinases Targeted Library contains 10,000 compounds. (chemdiv.com)
Yeast2
  • The classification, annotation and sequences of human, fly, worm and yeast kinases may now be explored through our KinBase database. (kinase.com)
  • In the fission yeast Schizosaccharomyces pombe (S. pombe) the anillin Mid1p, aurora Ark1p and the ESCRT family of proteins are involved in regulating specification of division site, mitotic entry and establishment of the final separation, respectively. (bl.uk)
MedlinePlus: Genes
MedlinePlus: Genes (medlineplus.gov)
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,... (medscape.com)
Tension directly stabilizes reconstituted kinetochore-microtubule attachments | Nature
Tension directly stabilizes reconstituted kinetochore-microtubule attachments | Nature (nature.com)
Targeted Cancer Therapy: Recent Developments in Targeted Cancer Treatment, Cancer Genetic and Epigenetic Changes, Ten Hallmarks...
Targeted Cancer Therapy: Recent Developments in Targeted Cancer Treatment, Cancer Genetic and Epigenetic Changes, Ten Hallmarks... (medscape.com)
Macrozoospermia: MedlinePlus Genetics
Macrozoospermia: MedlinePlus Genetics (medlineplus.gov)
Therapeutic Options Against BCR-ABL1 T315I-Positive Chronic Myelogenous Leukemia | Clinical Cancer Research | American...
Therapeutic Options Against BCR-ABL1 T315I-Positive Chronic Myelogenous Leukemia | Clinical Cancer Research | American... (aacrjournals.org)
Congress Looks to Review Patent Examiner Goals | Patently-O
Congress Looks to Review Patent Examiner Goals | Patently-O (patentlyo.com)
Aberrant RAG-mediated recombination contributes to multiple structural rearrangements in lymphoid blast crisis of chronic...
Aberrant RAG-mediated recombination contributes to multiple structural rearrangements in lymphoid blast crisis of chronic... (nature.com)
Investigation of bone invasion and underlying mechanisms of oral cancer using a cell line‑derived xenograft model
Investigation of bone invasion and underlying mechanisms of oral cancer using a cell line‑derived xenograft model (spandidos-publications.com)
Structural basis for microtubule recognition by the human kinetochore Ska complex | Nature Communications
Structural basis for microtubule recognition by the human kinetochore Ska complex | Nature Communications (nature.com)
BindingDB PrimarySearch_ki
BindingDB PrimarySearch_ki (bindingdb.org)
(emedicine.medscape.com)
Detecting Kinase Activity Across the Kinome
Detecting Kinase Activity Across the Kinome (promega.com)
BindingDB PrimarySearch_ki
BindingDB PrimarySearch_ki (bindingdb.org)
Leof, E. B.<...
Leof, E. B.<... (mayoclinic.pure.elsevier.com)
81e Congrès de l'ACFAS | Domaine 102 - Cancer
81e Congrès de l'ACFAS | Domaine 102 - Cancer (acfas.ca)
Internal Medicine - Research output - Mayo Clinic
Internal Medicine - Research output - Mayo Clinic (mayoclinic.pure.elsevier.com)
Aurora A kinase activation: Different means to different ends | Journal of Cell Biology | Rockefeller University Press
Aurora A kinase activation: Different means to different ends | Journal of Cell Biology | Rockefeller University Press (rupress.org)
Publications | Max Planck Institute of Biochemistry
Publications | Max Planck Institute of Biochemistry (biochem.mpg.de)
Whole Chromosome Instability induces senescence and promotes SASP | Scientific Reports
Whole Chromosome Instability induces senescence and promotes SASP | Scientific Reports (nature.com)
Cancers | Free Full-Text | Neuroendocrine Lung Cancer Mouse Models: An Overview
Cancers | Free Full-Text | Neuroendocrine Lung Cancer Mouse Models: An Overview (mdpi.com)
Plasmodium falciparumencodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti...
Plasmodium falciparumencodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti... (bmcbiol.biomedcentral.com)
Find Research outputs - Discovery - the University of Dundee Research Portal
Find Research outputs - Discovery - the University of Dundee Research Portal (discovery.dundee.ac.uk)
Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression | Journal of...
Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression | Journal of... (journals.biologists.com)
WikiGenes - ZW10 - zw10 kinetochore protein
WikiGenes - ZW10 - zw10 kinetochore protein (wikigenes.org)
PUB - Publikationen an der Universität Bielefeld
PUB - Publikationen an der Universität Bielefeld (pub.uni-bielefeld.de)
Recombinant Mouse EGF-containing fibulin-like extracellular matrix protein 1 (Efemp1) | CSB-MP007450MO | Cusabio
Recombinant Mouse EGF-containing fibulin-like extracellular matrix protein 1 (Efemp1) | CSB-MP007450MO | Cusabio (joplink.net)
Results for 'Other secreted molecules' | Abcam: antibodies, proteins, kits...
Results for 'Other secreted molecules' | Abcam: antibodies, proteins, kits... (abcam.com)