Aurora Kinases: A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.Aurora Kinase B: An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. It mediates proper CHROMOSOME SEGREGATION and contractile ring function during CYTOKINESIS.Aurora Kinase A: An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION.Aurora Kinase C: Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. It is found primarily in GERM CELLS in the TESTIS, and may mediate CHROMOSOME SEGREGATION during SPERMATOGENESIS.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Protein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.RNA Interference: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Mitosis: A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.Aneugens: Agents which affect CELL DIVISION and the MITOTIC SPINDLE APPARATUS resulting in the loss or gain of whole CHROMOSOMES, thereby inducing an ANEUPLOIDY.Protein Kinase Inhibitors: Agents that inhibit PROTEIN KINASES.PiperazinesOrganophosphates: Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.Protein Kinase C: An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.Period Circadian Proteins: Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.Phosphatidylinositol 3-Kinases: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.Cryptochromes: Flavoproteins that function as circadian rhythm signaling proteins in ANIMALS and as blue-light photoreceptors in PLANTS. They are structurally-related to DNA PHOTOLYASES and it is believed that both classes of proteins may have originated from an earlier protein that played a role in protecting primitive organisms from the cyclical exposure to UV LIGHT.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Health Facility Merger: The combining of administrative and organizational resources of two or more health care facilities.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Library Services: Services offered to the library user. They include reference and circulation.Cell Line, Tumor: A cell line derived from cultured tumor cells.Xenograft Model Antitumor Assays: In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Drug Evaluation, Preclinical: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.ras Proteins: Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Proto-Oncogene Proteins B-raf: A raf kinase subclass found at high levels in neuronal tissue. The B-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Kinetochores: Large multiprotein complexes that bind the centromeres of the chromosomes to the microtubules of the mitotic spindle during metaphase in the cell cycle.Spindle Apparatus: A microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.Centrosome: The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).Cyclooctanes: A group of compounds with an 8-carbon ring. They may be saturated or unsaturated.Tetrahydronaphthalenes: Partially saturated 1,2,3,4-tetrahydronaphthalene compounds.Polycyclic Compounds: Compounds consisting of two or more fused ring structures.MuseumsSchisandra: A plant genus of the family SCHISANDRACEAE. Members contain schisandrins (Russian) which are also called gomisins (Japanese) or wuweizins (Chinese). The compounds in this genus are very similar to those in the related KADSURA and medicinal usage is very similar. It is sometimes adulterated with KADSURA.Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. (1/1165)

We earlier isolated cDNAs encoding novel human protein kinases AIK and AIK2 sharing high amino acid sequence identities with Drosophila Aurora and Saccharomyces cerevisiae Ipl1 kinases whose mutations cause abnormal chromosome segregation. In the present study, a third human cDNA (AIK3) highly homologous to aurora/IPL1 was isolated, and the nucleotide sequence was determined. This cDNA encodes 309 amino acids with a predicted molecular mass of 35.9 kDa. C-terminal kinase domain of AIK3 protein shares high amino acid sequence identities with those of Aurora/Ipl1 family protein kinases including human AIK, human AIK2, Xenopus pEg2, Drosophila Aurora, and yeast Ipl1, whereas the N-terminal domain of AIK3 protein shares little homology with any other Aurora/Ipl1 family members. AIK3 gene was assigned to human chromosome 19q13.43, which is a frequently deleted or rearranged region in several tumor tissues, by fluorescence in situ hybridization, somatic cell hybrid panel, and radiation hybrid cell panel. Northern blot analyses revealed that AIK3 expression was limited to testis. The expression levels of AIK3 in several cancer cell lines were elevated severalfold compared with normal fibroblasts. In HeLa cells, the endogenous AIK3 protein level is low in G1/S, accumulates during G2/M, and reduces after mitosis. Immunofluorescence studies using a specific antibody have shown that AIK3 is localized to centrosome during mitosis from anaphase to cytokinesis. These results suggest that AIK3 may play a role(s) in centrosome function at later stages of mitosis.  (+info)

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. (2/1165)

Chromosome segregation depends on kinetochores, the structures that mediate chromosome attachment to the mitotic spindle. We isolated mutants in IPL1, which encodes a protein kinase, in a screen for budding yeast mutants that have defects in sister chromatid separation and segregation. Cytological tests show that ipl1 mutants can separate sister chromatids but are defective in chromosome segregation. Kinetochores assembled in extracts from ipl1 mutants show altered binding to microtubules. Ipl1p phosphorylates the kinetochore component Ndc10p in vitro and we propose that Ipl1p regulates kinetochore function via Ndc10p phosphorylation. Ipl1p localizes to the mitotic spindle and its levels are regulated during the cell cycle. This pattern of localization and regulation is similar to that of Ipl1p homologs in higher eukaryotes, such as the human aurora2 protein. Because aurora2 has been implicated in oncogenesis, defects in kinetochore function may contribute to genetic instability in human tumors.  (+info)

Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. (3/1165)

Ark1p (actin regulating kinase 1) was identified as a yeast protein that binds to Sla2p, an evolutionarily conserved cortical actin cytoskeleton protein. Ark1p and a second yeast protein, Prk1p, contain NH2-terminal kinase domains that are 70% identical. Together with six other putative kinases from a number of organisms, these proteins define a new protein kinase family that we have named the Ark family. Lack of both Ark1p and Prk1p resulted in the formation of large cytoplasmic actin clumps and severe defects in cell growth. These defects were rescued by wild-type, but not by kinase-dead versions of the proteins. Elevated levels of either Ark1p or Prk1p caused a number of actin and cell morphological defects that were not observed when the kinase-dead versions were overexpressed instead. Ark1p and Prk1p were shown to localize to actin cortical patches, making these two kinases the first signaling proteins demonstrated to be patch components. These results suggest that Ark1p and Prk1p may be downstream effectors of signaling pathways that control actin patch organization and function. Furthermore, results of double-mutant analyses suggest that Ark1p and Prk1p function in overlapping but distinct pathways that regulate the cortical actin cytoskeleton.  (+info)

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. (4/1165)

A centrosomal serine/threonine kinase, AIK1(3)/breast tumor amplified kinase/aurora2, which was recently identified as an oncogene, shows high amino acid identity with chromosome segregation kinases, fly Aurora, and yeast Ipl1. Immunohistochemical analyses of invasive ductal adenocarcinomas of the breast revealed that overexpression of AIK1 was observed in 94% of the cases, irrespective of the histopathological type, whereas the protein was not detected in normal ductal and lobular cells. Benign breast lesions including fibrocystic disease and fibroadenoma (epithelial components) displayed weakly detectable AIK1 expression in part of the lesions. This is the first immunohistochemical report of AIK1 expression in primary human breast carcinomas. Although the physiological function(s) of AIK1 kinase during cell division remains to be determined, the markedly high positivity of AIK1 staining in the cancer lesions suggested a possible involvement of its overexpression in the tumorigenesis of some of breast cancer cells.  (+info)

The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5. (5/1165)

We have previously reported on the cloning of XlEg5, a Xenopus laevis kinesin-related protein from the bimC family (Le Guellec, R., Paris, J., Couturier, A., Roghi, C., and Philippe, M. (1991) Mol. Cell. Biol. 11, 3395-3408) as well as pEg2, an Aurora-related serine/threonine kinase (Roghi, C., Giet, R., Uzbekov, R., Morin, N., Chartrain, I., Le Guellec, R., Couturier, A., Doree, M., Philippe, M., and Prigent, C. (1998) J. Cell Sci. 111, 557-572). Inhibition of either XlEg5 or pEg2 activity during mitosis in Xenopus egg extract led to monopolar spindle formation. Here, we report that in Xenopus XL2 cells, pEg2 and XlEg5 are both confined to separated centrosomes in prophase, and then to the microtubule spindle poles. We also show that pEg2 co-immunoprecipitates with XlEg5 from egg extracts and XL2 cell lysates. Both proteins can directly interact in vitro, but also through the two-hybrid system. Furthermore immunoprecipitated pEg2 were found to remain active when bound to the beads and phosphorylate XlEg5 present in the precipitate. Two-dimensional mapping of XlEg5 tryptic peptides phosphorylated in vivo first confirmed that XlEg5 was phosphorylated by p34(cdc2) and next revealed that in vitro pEg2 kinase phosphorylated XlEg5 on the same stalk domain serine residue that was phosphorylated in metabolically labeled XL2 cells. The kinesin-related XlEg5 is to our knowledge the first in vivo substrate ever reported for an Aurora-related kinase.  (+info)

Stu-7/air-2 is a C. elegans aurora homologue essential for chromosome segregation during embryonic and post-embryonic development. (6/1165)

We have isolated a new sterile uncoordinated C. elegans mutant, stu-7, which is defective in post-embryonic cell divisions in a regionally-specific fashion. The anterior of the worm is relatively unaffected whereas the mid-body and/or posterior are markedly thin, often resulting in worms having a central 'waist'. We have cloned stu-7 and found that it encodes a member of the recently expanding aurora sub-family of serine/threonine kinases. Elimination of maternal as well as zygotic stu-7 expression reveals that stu-7 is essential for mitosis from the first embryonic cell cycle onwards and is required for chromosome segregation though not for centrosome separation or for setting up a bipolar spindle. Multicopy expression of stu-7 also causes mitotic defects, suggesting that the level of this protein must be tightly controlled in order to maintain genetic stability during development.  (+info)

Cdc20 associates with the kinase aurora2/Aik. (7/1165)

Cdc20/fizzy family proteins are involved in activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent proteolysis of cell cycle regulatory proteins such as anaphase inhibitors and mitotic cyclins, leading to chromosome segregation and exit from mitosis. Previous work has shown that human Cdc20 (hCdc20/p55CDC) associates with one or more kinases. We report here that Cdc20-associated myelin basic protein kinase activity peaks sharply in early M phase (embryonic cells) or in G2 phase (somatic cells). In HeLa cells, Cdc20 is associated with the kinase aurora2/Aik. Aurora2/Aik is a member of the aurora/Ipl1 family of kinases that, like Cdc20, previously has been shown to be localized at mitotic spindle poles and is involved in regulating chromosome segregation and maintaining genomic stability. The demonstration that Cdc20 is associated with aurora2/Aik suggests that some function of Cdc20 is carried out or regulated through its association with aurora2/Aik.  (+info)

Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. (8/1165)

The conserved Ipl1 protein kinase is essential for proper chromosome segregation and thus cell viability in the budding yeast Saccharomyces cerevisiae. Its human homologue has been implicated in the tumorigenesis of diverse forms of cancer. We show here that sister chromatids that have separated from each other are not properly segregated to opposite poles of ipl1-2 cells. Failures in chromosome segregation are often associated with abnormal distribution of the spindle pole-associated Nuf2-GFP protein, thus suggesting a link between potential spindle pole defects and chromosome missegregation in ipl1 mutant cells. A small fraction of ipl1-2 cells also appears to be defective in nuclear migration or bipolar spindle formation. Ipl1 associates, probably directly, with the novel and essential Sli15 protein in vivo, and both proteins are localized to the mitotic spindle. Conditional sli15 mutant cells have cytological phenotypes very similar to those of ipl1 cells, and the ipl1-2 mutation exhibits synthetic lethal genetic interaction with sli15 mutations. sli15 mutant phenotype, like ipl1 mutant phenotype, is partially suppressed by perturbations that reduce protein phosphatase 1 function. These genetic and biochemical studies indicate that Sli15 associates with Ipl1 to promote its function in chromosome segregation.  (+info)

*Aurora kinase

As mentioned above, there are three classes of aurora kinases: Aurora A (a.k.a. Aurora 2) functions during prophase of mitosis ... Aurora kinases are serine/threonine kinases that are essential for cell proliferation. The enzyme helps the dividing cell ... Aurora inhibitor Bolanos-Garcia V M. Aurora kinases. The International Journal of Biochemistry & Cell Biology 37 (2005) 1572- ... Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. Journal of Cell ...

*Aurora A kinase

The human genome contains three members the Aurora kinase family: Aurora A kinase, Aurora B kinase and Aurora C kinase. The ... Aurora A and Aurora B kinases play important roles in mitosis. The Aurora A kinase is associated with centrosome maturation and ... Aurora A phosphorylation directs the cytoplasmic polyadenylation translation of mRNA's, like the MAP kinase kinase kinase ... contain orthologues only to Aurora A and Aurora B. In all studied species, the three Aurora mitotic kinases localize to the ...

*Aurora B kinase

... has been shown to interact with: BARD1, BIRC5, and CDCA8 TACC1. Abnormally elevated levels of Aurora B kinase ... Phosphorylation of CENP-A at serine 7 by Aurora A kinase recruits Aurora B to the centromere. Aurora B, itself, can also ... The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to ... In 1998, Aurora kinase B was identified in humans by a polymerase chain reaction screen for kinases that are overexpressed in ...

*Spindle checkpoint

... strong interest has shifted towards the aurora kinase proteins. The kinase gene Aurora A when amplified acts as an oncogene ... The localization of MAD2 and BubR1 to the kinetochore may also be dependent on the Aurora B kinase. Cells lacking Aurora B fail ... Aurora-B/Ipl1 kinase of the chromosomal passenger complex functions as the tensions sensor in improper kinetochore attachments ... The Aurora-B/Ipl1 kinase is also critical in correcting merotelic attachments, where one kinetochore is simultaneously attached ...

*Multipolar spindles

Aurora kinase has two forms which are designated Aurora kinase A and Aurora kinase B. These proteins play a key role in mitosis ... In some human cancers, the expression and kinase activity of Aurora kinases have been up-regulated and has been looked into as ... A possible causes of multipolar spindle formation involve regulation of protein kinase family known as Aurora kinase. ... Jingyan Fu, Fu (26 January 2007). "Roles of Aurora Kinases in Mitosis and Tumorigenesis". Molecular Cancer Research. 5 (1): 1- ...

*Sapacitabine

"Cyclin Dependent Kinase (CDK) and Aurora Kinase (AK) inhibitors , Cyclacel R&D for anticancer drugs acting on cell cycle". www. ...

*Spindle apparatus

Aurora kinases are required for proper spindle assembly and separation. Aurora A associates with centrosomes and is believed to ... Spindle assembly is largely regulated by phosphorylation events catalyzed by mitotic kinases. Cyclin dependent kinase complexes ... with many of these proteins serving as Aurora and Polo-like kinase substrates. In a properly formed mitotic spindle, bi- ... Polo-like kinase, also known as PLK, especially PLK1 has important roles in the spindle maintenance by regulating microtubule ...

*Phragmoplast

"Arabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation". The Plant Cell. 23 (11): 4013-4024. doi: ... Another midline-localized protein, "two-in-on" (TIO), is a putative kinase and is also required for cytokinesis as shown by ... "Microtubule-Associated Kinase-like Protein RUNKEL Needed for Cell Plate Expansion in Arabidopsis Cytokinesis". Current Biology ... Oh, Sung Aeong; Bourdon, Valérie; Dickinson, Hugh G.; Twell, David; Park, Soon Ki (2014-03-01). "Arabidopsis Fused kinase TWO- ...

*N-Myc

"Drugging MYCN through an Allosteric Transition in Aurora Kinase A". Cancer Cell. 26: 414-27. doi:10.1016/j.ccr.2014.07.015. PMC ... N-Myc is also stabilized by aurora A which protects it from degradation. Drugs that target this interaction are under ... development, and are designed to change the conformation of aurora A. Conformational change in Aurora A leads to release of N- ... "Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma". Cancer Cell. 15 (1): 67-78. doi:10.1016/j. ...

*NEDD9

"NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of ... Interaction of NEDD9 with Aurora A kinase may also play a role in tumor invasion. NEDD9 binds to and regulates acetylation of ... NEDD9 binds directly to the Aurora-A mitotic kinase at the centrosome, and promotes its activity, allowing cells to enter ... Other phosphorylation events in this region are imposed by the kinase Aurora-A, which phosphorylates residue S296, for ...

*K562 cells

The problem with K562 cells, and many other cancer cell types, is an overabundance of Aurora kinases. These kinases play a role ... However, the overabundance of Aurora kinases allows for uncontrolled cellular division, resulting in cancer. Inhibiting these ... This gene targets the cyclin-dependent kinase inhibitor, p21, and causes cell differentiation, cell cycle arrest in G1, and ...

*Said Sebti

Other kinases that have interested Sebti include Rho-associated kinase and Aurora kinase. STAT3. In 2003 the Sebti lab ... May 30, 2014). "Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation". Oncotarget. 5 (10): ... Kinases. Sebti's work on the kinase Akt led to his interest in Triciribine. ... October 1, 2012). "RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor ...

*NDC80

"Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model". ... Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH (Dec 2002). "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is ... Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH (Dec 2002). "Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is ... and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". ...

*Aurora inhibitor

There are three mammalian aurora kinase genes, encoding aurora A, B and C. Intense investigation has focused on aurora A and B ... Aurora-B (Serine/threonine-protein kinase 12, AIK2, AIM1, ARK2, STK12) Aurora-C (Serine/threonine-protein kinase 13, AIE2, AIK3 ... Aurora kinases, so named because the scattered mitotic spindles generated by mutant forms resemble the Aurora Borealis, have ... Targeting Aurora Kinases for the Treatment of Prostate Cancer. Cancer Res. (2006) 66: pp.4996-5002. Hua Yang et al., Aurora-A ...

*NUF2

2004). "Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model". ... "Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1". Chromosoma. 113 (1): 1-15. ...

*Mir-17 microRNA precursor family

He S, Yang S, Deng G, Liu M, Zhu H, Zhang W, Yan S, Quan L, Bai J, Xu N (2010). "Aurora kinase A induces miR-17-92 cluster ... "miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat ...

*BI811283

Aurora B kinase is produced in all dividing cells in normal tissue however; the levels of Aurora B kinase are abnormally raised ... The Aurora B kinase protein (also known as STK12) is one of a family of proteins that plays an essential role in the alignment ... Inhibition of Aurora B kinase by BI 811283 in cancer cells leads to the formation of cells with severely abnormal numbers of ... BI 811283 may be active in a range of malignancies that are known to have raised levels of Aurora B kinase including; non-small ...

*Fam158a

"Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression". Blood. 114 (13): 2699-708. ...

*Patient derived xenograft

December 2012). "Inhibiting aurora kinases reduces tumor growth and suppresses tumor recurrence after chemotherapy in patient- ... Utilizing PDX triple negative breast cancer models, scientists found that aurora kinase inhibitors slows tumor growth rate and ...

*HIST1H3F

2000). "Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and ...

*HIST1H3B

2000). "Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and ... Goto H, Yasui Y, Nigg EA, Inagaki M (2002). "Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic ... "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase". Nucleic Acids Res. 31 (3): 878-85. ...

*Biorientation

estimate that about 90% of chromosomes require correction of the kinetochore-microtubule attachments (using Aurora kinase ) ... which are then often corrected prior to anaphase onset by a system which uses protein kinase to affect kinetochore microtubules ...

*CDCA8

... has been shown to interact with INCENP, Survivin and Aurora B kinase. GRCh38: Ensembl release 89: ENSG00000134690 - ... "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung ...

*Cyclacel

CYC116, an Aurora kinase and VEGFR2 inhibitor, is in a Phase 1 trial in patients with solid tumors. Cyclacel Pharmaceuticals' ... the mitotic kinases, Polo and Aurora, enzymes that act in the mitosis phase of the cell cycle. Three product candidates are ... Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 studies for the treatment of ...

*Epithelial-mesenchymal transition

Brachyury, Axl, MEK, and Aurora kinase A are molecular drivers of these programs, and inhibitors are currently in clinical ... Silmitasertib (CX-4945) is a small molecule inhibitor of protein kinase CK2, which has been supported to be linked with TGF-β ... The phosphatidylinositol 3' kinase (PI3K)/AKT axis, Hedgehog signaling pathway, nuclear factor-kappaB and Activating ... Another small molecule inhibitor Galunisertib (LY2157299) is a potent TGF-β type I receptor kinase inhibitor that was ...

*DSN1

"Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore". J. Biol. Chem. 283 (39): ...
Recently, Aurora kinases (A, B, and C/serine threonine kinases) gained much attention due to their implication in several types of cancers. Aurora kinases are involved in multiple functions in mitosis. Aurora A is involved in mitotic entry, separation of centriole pairs, accurate bipolar spindle assembly, alignment of metaphase chromosomes and completion of cytokinesis. Aurora B is a chromosomal passenger protein involved in the regulation of chromosomal orientation, and regulating the association between kinetochores and microtubules, and cytokinesis. Aurora C exhibits similar functions to those assigned to Aurora B and is required for cytokinesis. The above mentioned functions are directly involved in maintaining genomic stability. The relation between Aurora kinases overexpression and transformation has been reported in many cancers. Aurora A was shown to overexpress in colorectal, renal, melanoma, and breast cancers. Mainly Aurora B was shown to overexpress in colorectal cancer. Aurora B was ...
Aurora B kinase is essential for faithful chromosome segregation during mitosis. During (pro)metaphase, Aurora B is concentrated at the inner centromere by the kinases Haspin and Bub1. However, how Haspin and Bub1 collaborate to control Aurora B activity at centromeres remains unclear. Here, we show that either Haspin or Bub1 activity is sufficient to recruit Aurora B to a distinct chromosomal locus. Moreover, we identified a small, Bub1 kinase-dependent Aurora B pool that supported faithful chromosome segregation in otherwise unchallenged cells. Joined inhibition of Haspin and Bub1 activities fully abolished Aurora B accumulation at centromeres. While this impaired the correction of erroneous KT-MT attachments, it did not compromise the mitotic checkpoint, nor the phosphorylation of the Aurora B kinetochore substrates Hec1, Dsn1, and Knl1. This suggests that Aurora B substrates at the kinetochore are not phosphorylated by centromere-localized pools of Aurora B, and calls for a reevaluation of ...
Whether aurora A or aurora B is the better anticancer drug target is a matter of debate (8). At least two groups have directly addressed this question in the laboratory. Warner et al. (36) compared the effects of aurora A and aurora B antisense oligonucleotides in pancreatic cancer cells and found that aurora A-targeted therapy may be preferable to aurora B targeting, as shown by mitotic arrest and the rapid induction of apoptosis. Girdler et al. (37) compared the effects of RNA interference and small molecules targeting aurora A versus aurora B in colon cancer cells and found that the cells tested were extremely sensitive to aurora B inhibition. Interestingly, dual inhibition of aurora A and B results in phenotypes identical to inactivation of aurora B alone (28). Using RNA interference experiments, Yang et al. (38) showed that inactivation of aurora B indeed bypasses the requirement for aurora A and leads to polyploidy, indicating that aurora B is responsible for mitotic arrest in the absence ...
Aurora B kinase is a protein that functions in the attachment of the mitotic spindle to the centromere. Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004).[supplied by OMIM] In cancerous cells, over-expression of these enzymes causes unequal distribution of genetic information, creating aneuploid cells, a hallmark of cancer. In 1998, Aurora kinase B was identified in humans by a polymerase chain reaction screen for kinases that are overexpressed in cancers. In the same year, rat Aurora kinase B was identified in a screen designed to find kinases that altered S. cerevisiae proliferation when overexpressed. The expression and activity of Aurora B are regulated ...
Aurora kinases play distinct roles during mitosis, with Aurora A being essential for centrosome maturation and spindle assembly and Aurora B functioning at kinetochores in chromosome attachment and at the end of mitosis in cytokinesis (reviewed in refs. 3, 4).. Inhibition of Aurora kinases is emerging as a new strategy for anticancer therapy, and several small-molecule inhibitors have entered clinical trials. In this report, we describe the biochemical and pharmacologic activity profile of PHA-739358, a spectrum-selective small-molecule kinase inhibitor, which was identified during a screen for inhibitors of Aurora kinases. In most of the cell lines tested, cells fail to divide, resulting in polyploidy without a strong impact on the timing of mitosis (data not shown) and finally leading to a reduction in viability. In some cell lines, an increased apoptosis was seen. This speaks for a dominant Aurora B kinase-related mechanism of action for inhibition because Aurora A inhibition would rather ...
We have characterised the role played by the aurora-related kinase Ark1 in regulating mitotic progression in fission yeast. In contrast to metazoans, where aurora A is required for spindle formation and aurora B required for both chromosome condensation and cytokinesis, a single aurora kinase, Ark1, is required for mitosis in S. pombe. The phenotypes arising in cells that lack Ark1 suggest that this single kinase is performing functions that are related to the functions of each of the two isoforms in higher systems. The spindle formation defects of ark1.Δ1 cells resemble the consequences of perturbing aurora A function in Drosophila and Xenopus (Glover et al., 1995; Roghi et al., 1998), while the lack of chromosome resolution during anaphase resembles aurora B deficiencies in C. elegans and Drosophila (Adams et al., 2001b; Giet and Glover, 2001; Kaitna et al., 2000; Severson et al., 2000b). Although we failed to detect a requirement for Ark1 during cytokinesis, it remains a possibility that, ...
Background: It is known that aurora B, a chromosomal passenger protein responsible for the proper progression of mitosis and cytokinesis, is overexpressed throughout the cell cycle in cancer cells. Overexpression of aurora B produced multinuclearity and induced aggressive metastasis, suggesting that overexpressed aurora B has multiple functions in cancer development. However, the detailed dynamics and functions of overexpressed aurora B are poorly understood. Results: We overexpressed GFP fused aurora B kinase in normal rat kidney epithelial cells. Using spinning disk confocal microscopy, we found that overexpressed aurora B-GFP was predominantly localized in the nucleus and along the cortex as a dot-like or short filamentous structure during interphase. Time-lapse imaging revealed that a cytoplasmic fraction of overexpressed aurora B-GFP was incorporated into the nucleus after cell division. Immunofluorescence showed that the nuclear fraction of overexpressed aurora B did not induce ectopic ...
Successful cell division requires that chromosomes attach to opposite poles of the mitotic spindle (bi-orientation). Aurora B kinase regulates chromosome-spindle attachments by phosphorylating kinetochore substrates that bind microtubules. Centromere tension stabilizes bi-oriented attachments, but how physical forces are translated into signaling at individual centromeres is unknown. Using fluorescence resonance energy transfer-based biosensors to measure localized phosphorylation dynamics in living cells, we found that phosphorylation of an Aurora B substrate at the kinetochore depended on its distance from the kinase at the inner centromere. Furthermore, repositioning Aurora B closer to the kinetochore prevented stabilization of bi-oriented attachments and activated the spindle checkpoint. Thus, centromere tension can be sensed by increased spatial separation of Aurora B from kinetochore substrates, which reduces phosphorylation and stabilizes kinetochore microtubules.. ...
SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A); 1 nM (Aurora B / incenp); 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP 3A4 and PDE3 inhibition. In vitro, SAR156497 displayed high antiproliferative activity on a large panel of tumor cell lines without correlation with any particular genetic signature or Aurora kinases expression. It induced significant modulation of Aurora A and Aurora B biomarkers (p-Aurora A and pHH3, respectively) and cell polyploidy, as expected from Aurora A/B inhibitors. In vivo efficacy has been demonstrated on relevant tumor models, but unfortunately, SAR156497 displayed a narrow therapeutic window.
Background: Aurora kinases are promising targets for cancer chemotherapy. Many reports have been published that some cancers overexpress Aurora kinases, which correlates with tumor grade and poor prognosis. Hence Aurora kinases were considered key genes for cancerogenesis and progression. Many Aurora kinase inhibitors(AKI,s) are in various phases of pre-clinical and clinical development and promising anticancer effects have been reported. Tumor resistance remains one of the major problems in chemotherapy.. Objectives: Our work is mainly aimed at identification of potential resistance mechanisms towards CYC116 (new small molecule pan Aurora kinase inhibitor) and ZM447439. The main aims include generation and selection of resistant tumor cell clones, characterization of resistance, cross resistance with other AKI,s and multidrug resistance. Further characterization of the resistant clones included cell cycle analysis, expression and DNA sequencing of Aurora kinases, cellular target inhibition, and ...
Aurora Kinase A Pipeline Review H2 Market 2019. Aurora Kinase A Pipeline Review H2 Market Size by Types, Applications, Major Regions and Major Manufacturers including the capacity, production, price, revenue, cost, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies.
The Aurora family of serine-threonine kinases are essential regulators of cell division in mammalian cells. Aurora-A and -B expression and kinase activity is elevated in a variety of human cancers and is associated with high proliferation rates and poor prognosis. AMG 900 is a highly potent and selective pan-aurora kinase inhibitor that has entered clinical evaluation in adult patients with advanced cancers. In mice, oral administration of AMG 900 blocks the phosphorylation of histone H3 on serine-10 (p-Histone H3), a proximal substrate of aurora-B and inhibits the growth of multiple human tumor xenografts, including multidrug-resistant models. In order to establish a preclinical pharmacokinetic-pharmacodynamic (PK-PD) relationship for AMG 900 that could be translated to the clinic, we used flow cytometry and laser scanning cytometry detection platforms to assess the effects on p-Histone H3 inhibition in terms of sensitivity, precision, and specificity, in human tumor xenografts in conjunction with
TY - JOUR. T1 - Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. AU - Katsha, Ahmed. AU - Soutto, Mohammed. AU - Sehdev, Vikas. AU - Peng, Dunfa. AU - Washington, M. Kay. AU - Piazuelo, M. Blanca. AU - Tantawy, Mohammed N.. AU - Manning, H. Charles. AU - Lu, Pengcheng. AU - Shyr, Yu. AU - Ecsedy, Jeffrey. AU - Belkhiri, Abbes. AU - El-Rifai, Wael. PY - 2013/1/1. Y1 - 2013/1/1. N2 - Background & Aims Chronic inflammation contributes to the pathogenesis of gastric tumorigenesis. The aurora kinase A (AURKA) gene is frequently amplified and overexpressed in gastrointestinal cancers. We investigated the roles of AURKA in inflammation and gastric tumorigenesis. Methods We used quantitative real-time reverse transcription polymerase chain reaction, immunofluorescence, immunohistochemistry, luciferase reporter, immunoblot, co-immunoprecipitation, and in vitro kinase assays to analyze AGS and MKN28 gastric cancer cells. We also analyzed Tff1-/- mice, growth of ...
The purpose of this study is to assess the safety and tolerability of MK-0457(VX-680), an Aurora kinase inhibitor, in participants with advanced solid tumors. Bioavailability of the oral formulation will also be assessed. The primary study hypothesis is that administration of MK-0457 is sufficiently safe and tolerated to permit further study ...
OUTLINE: This is an open-label, dose-escalation, multicenter study.. Patients receive Aurora kinase inhibitor AT9283 (AT9283) IV over 24 hours on days 1 and 8 . Treatment repeats every 3 weeks in the absence of disease progression or unacceptable toxicity.. Cohorts of 3-6 patients receive escalating doses of AT9283 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which at least 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. The dose preceding the MTD is the recommended phase II dose (RPTD). Up to 8 additional patients are treated at the RPTD.. Patients treated at the RPTD undergo skin and tumor tissue biopsy and blood collection at baseline and on days 2 and/or 3. Samples are examined by pharmacokinetic and pharmacodynamic analysis, including immunohistochemistry, immunocytochemistry, western blotting, immunoenzyme techniques, flow cytometry, and reverse transcriptase-polymerase chain reaction, for biological markers.. After completion of ...
The IUPHAR/BPS Guide to Pharmacology. aurora kinase inhibitor III ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
This study looks at how well cisplatin and gemcitabine hydrochloride, with or without ATR kinase inhibitor VX-970 works in treating patients with urothelial cancer that has spread to other places in the body. Drugs used in chemotherapy, such as cisplatin and gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. ATR kinase inhibitor VX-970 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known if cisplatin and gemcitabine hydrochloride work better alone or with ATR kinase inhibitor VX-970 in treating patients with urothelial cancer. ...
Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. Find all the information about Hesperadin for cell signaling research.
Although the MAPK pathway is frequently deregulated in cancer, inhibitors targeting RAF or MEK have so far shown clinical activity only in BRAF- and NRAS-mutant melanoma. Improvements in efficacy may be possible by combining inhibition of mitogenic signal transduction with inhibition of cell-cycle progression. We have studied the preclinical pharmacology of BI 847325, an ATP-competitive dual inhibitor of MEK and Aurora kinases. Potent inhibition of MEK1/2 and Aurora A/B kinases by BI 847325 was demonstrated in enzymatic and cellular assays. Equipotent effects were observed in BRAF-mutant cells, whereas in KRAS-mutant cells, MEK inhibition required higher concentrations than Aurora kinase inhibition. Daily oral administration of BI 847325 at 10 mg/kg showed efficacy in both BRAF- and KRAS-mutant xenograft models. Biomarker analysis suggested that this effect was primarily due to inhibition of MEK in BRAF-mutant models but of Aurora kinase in KRAS-mutant models. Inhibition of both MEK and Aurora ...
Aurora A (serine/threonine kinase 6) is overexpressed in many pre-invasive and invasive breast carcinomas. High expression of Aurora A is strongly associated with decreased survival in patients with breast cancer, but the molecular mechanisms that underlie Aurora-A-associated malignancy are poorly understood. Here, Kavita Shah and co-workers (p. 2711) use a new chemical genetic approach to identify the pleckstrin-homology-like domain protein PHLDA1 as a putative Aurora A target. The authors confirm previous reports that PHLDA1 is frequently downregulated in primary breast cancers and, in addition, show that PHLDA1 downregulation is associated with oestrogen receptor expression in breast carcinoma. Aurora A directly phosphorylates PHLDA1, which leads to its degradation, but PHLDA1 also negatively regulates Aurora A, thereby setting up a feedback loop. Finally, they show that PHLDA1 upregulation and Aurora A inhibition act synergistically to promote cell death, and that PHLDA1 strongly inhibits ...
At the outset of this work, the existence of a second aurora-like gene in Drosophila, aurora B, was already known (previously named ial; Reich et al. 1999), but there were no known mutations at the locus and the enzyme had not been localized within cells. The proximity of other genes made the prospect of generating such mutations by classical genetic means somewhat daunting and although a model system for the targeted disruption of genes has recently been developed (Rong and Golic 2000), this is also a time-consuming and not yet widely used procedure. In several organisms dsRNAi has offered opportunities for studying the genetic basis of many aspects of cell biology in the absence of mutations in the genes directing these activities. This has been perhaps best demonstrated in C. elegans, where the technique is most widely used (Hunter 1999, Hunter 2000). A simple system for dsRNAi in cultured Drosophila cells not only offers the means of eliminating specific gene expression (Caplen et al. 2000; ...
Once the dose levels reached 190 mg/m2, tests on skin biopsies showed that the drug was inhibiting the aurora B protein - in other words it was beginning to do what we expected it to.. "The aurora B protein is responsible for phosphorylating histone H3 - a protein involved in the structure of chromatin (the strands of DNA that make up chromosomes) in cells. Inhibition of aurora B results in the inhibition of phosphorylation of histone H3, thereby blocking that step in cell division. This study shows, for the first time, that the aurora kinase inhibitor PHA-739358 inhibits phosphorylation of histone H3 in the skin of patients, and therewith provides a proof for its (or one of its) mechanisms of action.". The researchers are continuing to recruit patients in order to define the safety of the drug and the recommended dose for subsequent studies. However, they believe the results so far are promising.. "The clinical trial has proved the concept that inhibition of the aurora protein disrupts an ...
5648 The Aurora family of serine/threonine kinases (Aurora A, Aurora B, and Aurora C) plays a key role in cells orderly progression through mitosis. Elevated expression levels of Aurora kinases have been detected in a high percentage of melanoma, colon, breast, ovarian, gastric, and pancreatic tumors, and in a subset of these tumors the AURKA locus (20q13) is amplified. SNS-314, a novel aminothiazole-derived urea, is a selective inhibitor of Aurora kinases A, B, and C with IC50 values in the low nanomolar range. SNS-314 potently inhibits cell proliferation and induces polyploidy (, 4N DNA) in a diverse panel of human cancer cell lines. In the present study we investigated the pharmacodynamic effects and in vivo activity of SNS-314 in human tumor xenograft models. SNS-314 displayed potent anti-tumor activity in HCT-116 (colon), PC-3 (prostate), CALU-6 (NSCLC) and MDA-MB-231 (breast) models. Tumor growth inhibition in these xenograft models ranged from 67.5 to 96.6% on a bi-weekly administration ...
ributed cell populations in G0 G1, S and G2 M phases. In contrast, OE33 and markedly OE19 and EPC hTERT cells selleck compound had a high G0 G1 phase population, with reduced S and G2 M phase populations. Aurora kinases in normal esophageal epithelial cells and esophageal cancer cells For Aurora A, fluorescence in situ hybridization revealed chromosome 20 polysomy with concomitantly elevated Aurora A gene copy num bers in OE21, OE33 and OE19 cells and an Aurora A gene amplification with up to nine Aurora A gene copies in Kyse 410 cells. In view of their Aurora A gene amplification, Kyse 410 cells also showed highest Aur ora A mRNA and high protein expression. In contrast, OE21, OE33 and OE19 cells exhibited lower Aurora A mRNA expression, despite chromosome 20 polysomy.. Still, high Aurora A protein expression was seen in OE33, but not OE21 and OE19 cells. Active Aurora A was hardly detectable in Inhibitors,Modulators,Libraries immunoblot analysis, but weak Aur ora A phosphoT288 levels were seen ...
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...[T]he [M.D. Anderson Cancer Center & Baylor College of Medicine] researchers concluded that [Aurora kinase] AK inhibition [produced by MK-0457] significantly reduces ovarian cancer tumor burden and cell proliferation, and increases tumor cell apoptosis in preclinical ovarian cancer mouse models. The researchers noted that the role of Aurora kinase inhibition in ovarian cancer merits further…
Full text for this publication is not currently held within this repository. Alternative links are provided below where available. ...
We present an analysis of flickering (2-10 Hz) auroras observed with a state-of-the-art multispectral imaging system, Auroral Structure and Kinetics, located in Tromso, Norway. Short (1-2 s) periods of flickering aurora have been identified in which the frequency of the brightness oscillations decreases or increases smoothly over time. To the authors knowledge this is the first detailed analysis of such "chirps" in flickering aurora or field-aligned bursts. We have found that the electron precipitation energy is strongly anticorrelated with the flickering frequency during all identified chirps. This result is consistent with the theory that flickering aurora is caused by the resonance interaction between electromagnetic ion cyclotron waves and precipitating electrons and that the wave parallel phase velocity is the primary factor determining the electron acceleration produced by this mechanism. Other current theories known to the authors cannot completely explain our observations.. ...
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References for Abcams Recombinant Human Aurora A protein (ab86846). Please let us know if you have used this product in your publication
AMG 900 is a potent and selective, orally available small molecule aurora kinase inhibitor. Buy Aurora Kinase inhibitor AMG 900 from AbMole BioScience.
ZM447439 does not prevent localization of Aurora B to centromeres. Immunofluorescence images of prometaphase DLD-1 cells stained to detect Aurora B (green), Sur
10 Feb 2016. In one of the first efforts to date to apply nanotechnology to targeted cancer therapeutics, researchers have created a nanoparticle formulation of a cancer drug that is both effective and nontoxic -- qualities harder to achieve with the free drug.. Their nanoparticle creation releases the potent but toxic targeted cancer drug directly to tumours, while sparing healthy tissue.. The findings in rodents with human tumours have helped launch clinical trials of the nanoparticle-encapsulated version of the drug, which are currently underway.. Aurora kinase inhibitors are molecularly targeted agents that disrupt cancers cell cycle.. While effective, the inhibitors have proven highly toxic to patients and have stalled in late-stage trials.. Development of several other targeted cancer drugs has been abandoned because of unacceptable toxicity.. To improve drug safety and efficacy, Susan Ashton and colleagues designed polymeric nanoparticles called Accurins to deliver an Aurora kinase B ...
We previously reported that phosphorylation of myosin II-interacting guanine nucleotide exchange aspect (MyoGEF) by polo-like kinase 1 (Plk1) promotes the localization of MyoGEF towards the central spindle and boosts MyoGEF activity toward RhoA during mitosis. that aurora B colocalizes with MyoGEF on the central midbody and spindle during cytokinesis. Suppression of aurora B activity by an aurora B inhibitor disrupts the localization of MyoGEF towards the central spindle. Furthermore T544A mutation inhibits the localization of MyoGEF towards the cleavage furrow and reduces MyoGEF activity toward RhoA during mitosis. Used together our outcomes claim that aurora B coordinates with Plk1 to modify MyoGEF activation and localization hence adding to the legislation of cytokinesis. translated Myc-aurora B was synthesized using the TNT SP6 quick-coupled transcription/translation program (Promega Madison WI) based on the manufacturers guidelines. Coimmunoprecipitation Assays Coimmunoprecipitation assays ...
También conocida como Aurora Boreal o Aurora Austral. Es un espectáculo natural de luz visible en los cielos nocturnos próximos a los polos. Las auroras están causadas por las partículas cargadas en el viento solar que chocan con los átomos de la atmósfera y provocan la emisión de luz. El color depende del tipo de átomo con el que colisionan: luz verde si son átomos de oxígeno, y roja si se trata de átomos de nitrógeno.. ...
The spectacular aurora borealis displays that light up the northern nights could be powered by a gigantic "slinky" effect in Earth s magnetic field lines, according to research performed at the University of Minnesota. Earth s magnetic field resemble a slinky in that when "wiggled," it undulates in waves that travel down the field lines at speeds up to 25 million miles per hour. These waves can pass energy to electrons, accelerating them along the magnetic field lines toward Earth. When the electrons hit atoms in the atmosphere, the atoms become excited and produce the colors of the aurora. Using electric and magnetic field data and images from NASA s POLAR satellite, the researchers showed that energy from such waves is sufficient to power auroras and that statistically, the waves occur in the same locations as auroras--in a ring around the poles. The work will be published in the Jan. 17 issue of Science. ...
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system. This system configures binary tools and library paths for you in a very flexible way. Read more about it in Lunarc documentation here: http://lunarc-documentation.readthedocs.io/en/latest/aurora_modules/ If you are in need of a module that is not installed, please check this list: https://github.com/hpcugent/easybuild-easyconfigs/tree/master/easybuild/easyconfigs If the software you need is in the list but NOT in Aurora, report to Florido, and he will coordinate with Lunarc to provide such software. If that module does not exist in the system nor in the above list, you will have to build it and configure yourself. Read more about it in the Custom software paragraph. ...
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Mitogen-activated protein kinase (MAPK)-triggered protein kinase 2 (MAPKAPK2) mediates multiple p38 MAPK-dependent inflammatory responses. at Ser-58. Computational modeling and calculation of theoretical binding energies predicted that both phosphorylation at Ser-58 and mutation of Ser-58 to Asp (S58D) jeopardized the ability of 14-3-3 to dimerize. Experimentally, S58D mutation significantly impaired both 14-3-3 dimerization and binding to Raf-1. These data suggest that MAPKAPK2-mediated phosphorylation regulates 14-3-3 functions, and this MAPKAPK2 activity may symbolize a novel pathway mediating p38 MAPK-dependent swelling. A diverse group of cellular responses are elicited by activation of a highly conserved family of mitogen-activated protein kinase (MAPK) signaling pathways, which includes extracellular signal-regulated kinases (ERKs), c-jun N-terminal kinases (JNKs), ERK5, and p38 MAPKs. A large body of evidence shows that p38 MAPK activity is critical to immune and inflammatory responses. ...
We describe a novel clinical phenotype associating T- and B-cell lymphopenia intermittent neutropenia and atrial septal flaws in 3 associates of the consanguineous kindred. with the STK4 ortholog DAF16 protects against cell loss of life induced by oxidative tension. Furthermore when DAF16 cannot perform the phosphorylation function living from the worms is normally measurably decreased. 19 Surprisingly Stk4-deficient mice experienced progressive loss of B and T cells because of excessive apoptosis. 20-22 STK4 could also possess a protective function maintaining cellular viability Thus. STK4 phosphorylates transcription elements within the FOXO family members including FOXO3 and FOXO1 within a stress-response pathway.19 21 STK4 participates in a number of other pathways. Binding of RASSF1A and NORE1A to STK4 homodimers inhibits STK4 kinase activity.20 23 Binding of RAPL to STK4 is vital for lymphocytes to polarize and adhere24 and potentially to regulate proper egress from thymus.22 Our ...
Address correspondence to P.J. Donovan, Kimmel Cancer Center, Thomas Jefferson University, 705 BLSB, 233 South Tenth St., Philadelphia, PA 19107. Tel.: (215) 503-1121. Fax: (215) 923-4153. E-mail: pdonovan{at}lac.jci.tju.edu ...
Nitric oxide (Zero) is certainly essential in the regulations of bone fragments remodeling, whereas high concentration of Zero promotes cell death of osteoblast. in dosage- and time-dependent way. SNP elevated phrase amounts of g62, ATG7, LC3-II and Beclin-1, as regular autophagic indicators and increased acidic autophagolysosomal vacuoles, discovered by acridine tangerine discoloration. Nevertheless, pretreatment with 3-methyladenine (3MA), the particular inhibitor for autophagy, reduced cell viability, whereas elevated the cleavage of PARP and caspase-3 in the SNP-treated MC3Testosterone levels3-Age1 cells. AMP-activated proteins kinase (AMPK), a main autophagy regulatory kinase, was turned on in SNP-treated MC3Testosterone levels3-Age1 cells. In addition, pretreatment with substance C, an inhibitor of AMPK, reduced cell viability, whereas elevated the accurate amount of apoptotic cells, cleaved PARP and caspase-3 amounts likened to those of SNP-treated MC3Testosterone levels3-Age1 cells. Used ...
The short isoform of ErbB3-binding protein 1 (Ebp1), p42, is considered to be a potent tumor suppressor in a true number of human cancers, although the mechanism by which it exerts this tumor-suppressive activity is unclear. amounts by relating g85 to HSP70/CHIP-mediated proteasomal destruction. Therefore, g42 features as an essential growth suppressor in human being tumor cells through adverse legislation of the balance of g85 subunit. Our data offer a fresh understanding into the system of deregulation of PI3E in growth cells, confirming HSP70/CHIP as a book Elizabeth3 ubiquitin ligase for g85 subunit. Outcomes The g42 particularly interacts with g85 regulatory subunit of PI3E Growth suppressors normally control cell development by Vanoxerine 2HCl mediating mitogenic signaling,20 and our research possess demonstrated that overexpression of g42 forbids Akt service, whereas g48 enhances Akt kinase activity.2, 21 In an work to determine how g42 features while a development suppressor, we ...
How can we prevent mass killings like Aurora? - AP News: AURORA, Colo. (AP) - On the morning of the latest .12/12/2017 19:16:42PM EST.
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Aurora - posted in Virus, Spyware, Malware Removal: Aurora is making my computer life a misery.Here is my Hijack file... I hope you are able to help. I have run adaware and spybot, to no avail. Ive tried following the advice youve offered to other sufferers, but the file names are different in each case and I dont want to delete anything crucial. Thanks, Moggo... btw, I hope you know the geeks2go is very popular over here in England as well as in The States.Logfile of HijackThis v1.99.1Sca...
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Bella Aurora Labs celebrates World Science Day by announcing the opening of its new cell culture laboratory. According to the Director of Research and Deve
AURORA -- At least 12 people were killed and 38 more injured in a mass shooting during a midnight screening of The Dark Knight Rises at an Aurora movie theater Friday. Go to this story for live, continuous updates.
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AURORA, Colo. -- The families of those slain at an Aurora movie theater in July recently received an invitation from Cinemark to attend the companys reopening of that same theater later this month.
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ZM 447439 | Aurora B inhibitor | ZM447439 | CAS [331771-20-1] | Axon 1541 | Axon Ligand™ with >99% purity available from supplier Axon Medchem, prime source of life science reagents for your research
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https://reecesrainbow.org/wp-content/uploads/Aurora-1.jpg 640 354 Michelle Zoromski https://reecesrainbow.org/wp-content/uploads/officialrrlogo350web.png Michelle Zoromski2014-11-04 14:35:382017-04-12 17:47:49Aurora ...
Xenografts were removed, minced into 1 mm pieces, and dissociated, 0. 8 unitsml Dispase, and 100 unitsml penicillin JNJ-7706621 Aurora Kinase inhibitor strepto
Javier Pinilla-Ibarz, MD, PhD, and Naval Daver, MD, describe some of the emerging therapies for chronic myeloid leukemia, such as aurora kinase inhibitors, and how treatment discontinuation is becoming a reality.
Ilorasertib, also know as ABT-348, is a novel, potent and orally bioavailable inhibitor of the Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases and is currently in Phase I clinical trials. ABT-348 has nanomolar potency (IC50) for inhibiting binding and cellular auto-phosphorylation of Aurora B (7 and 13 nM), C (1 and 13 nM) and A (120 and 189 nM). Based upon its unique spectrum of activity, ABT 348 was evaluated and found effective in representative solid tumor (HT1080 and MiaPaCa, tumor stasis) and hematological malignancy (RS4;11, regression) xenografts. These results provide the rationale for clinical assessment of ABT-348 as a therapeutic agent in the treatment of cancer.
helps the cell to divide successfully, even if it takes slightly longer", Gerlich explains.. Aurora B delays cell division until chromosome bridges resolve. The researchers identified the already known enzyme Aurora B as an important player in the process. "We noticed that Aurora B ...
Auroral events have been thin on the ground for a while here in Australia, but the South Pole Station All Sky Imager is back on line and has been capturing polar auroras for us to enjoy. Check out the Near-real time images ...
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If you happen to be reasonably close to one of the Earths magnetic poles, the next time theres a particularly intense aurora, go outside. Get as far as y
The aforementioned "Aurora??" range is based on our proprietary blend of refined vegetable extracts, which are fully biodegradable and have a very low order of oral toxicity. The bottle comes with a Child Safety Cap as well as a spout to enable the consumer to fill all manner of systems easily. ?This range of coolants is recommended for use in systems where an environmentally friendly product is preferred. It also contains non-toxic (GRAS) multi-metal inhibitors, formulated to protect the water cooling equipment and associated systems against corrosion, scale and biological fouling. This prolongs equipment life and thermal efficiency ...
MK 5108 | Aurora A Inhibitor | VX 689 | MK5108 | VX689 | CAS [1010085-13-8] | Axon 1961 | Axon Ligand™ with >98% purity available from supplier Axon Medchem, prime source of life science reagents for your research
Find information about Aurora University paramedic certificate. Whether you are considering an associates degree (CNA, LVN, or LPN), or a bachelor of science in nursing (RN), you will find many doors opening after graduation.
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CNNs Randi Kaye tells the story of survivors who lived through the gunfire in the Aurora, Colorado, movie theater. Katie and Caleb Medley are high school sweethearts who had their first baby, Hugo, this morning. Both were caught in the attack.
CNNs Randi Kaye tells the story of survivors who lived through the gunfire in the Aurora, Colorado, movie theater. Katie and Caleb Medley are high school sweethearts who had their first baby, Hugo, this morning. Both were caught in the attack.
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Recent releases in Mobile have including a lot of code changes in the Aurora channel. We plan to start doing less of this in the future and the future is now. The Aurora merge is on June 4 and we need to plan to have as much Fx15 feature work landed as possible. Yes, we still plan to do some work while in Aurora, but we have to start cutting back. Lets try to get some of the larger chunks of new features reviewed and landed this week. Make sure we can disable/backout features that wont make it fully in Aurora ...
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a very quick internet search on how people photograph the aurora was quickly put into practice outside our cabin at Saltjern when it started early -- a pretty impressive display and my first encounter with the phenomenon but as usual I was left thinking I could have mad a better job of the ...
Learn more about Treatments for Asthma at Medical Center of Aurora Main Page Risk Factors Symptoms ...
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Case opinion for US 9th Circuit SANCHEZ v. Aurora, on behalf of themselves and all others similarly situated, Defendant.. Read the Courts full decision on FindLaw.
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A young woman shot in the brain during Saturdays deadly massacre in Aurora, Colorado has made what is being called a miracle recovery that doctors say is due to a cranial birth defect.
TY - JOUR. T1 - Aurora B-INCENP localization at centromeres/inner kinetochores is required for chromosome bi-orientation in budding yeast. AU - García-Rodríguez, Luis J.. AU - Kasciukovic, Taciana. AU - Denninger, Viola. AU - Tanaka, Tomoyuki. N1 - Funding: ERC (322682) and Wellcome Trust (096535/Z/11/Z).. PY - 2019/5/6. Y1 - 2019/5/6. N2 - For proper chromosome segregation in mitosis, sister kinetochores must interact with microtubules from opposite spindle poles (chromosome bi-orientation) [1, 2]. To promote bi-orientation, Aurora B kinase disrupts aberrant kinetochore-microtubule interactions [3-6]. It has long been debated how Aurora B halts this action when bi-orientation is established and tension is applied across sister kinetochores. A popular explanation for it is that, upon bi-orientation, sister kinetochores are pulled in opposite directions, stretching the outer kinetochores [7, 8] and moving Aurora B substrates away from Aurora-B-localizing sites at centromeres (spatial separation ...
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The chromosomal passenger complex (CPC) localizes to centromeres in early mitosis to activate its subunit Aurora B kinase. However, it is unclear whether centromeric CPC localization contributes to CPC functions beyond Aurora B activation. Here, we show that an activated CPC that cannot localize to centromeres supports functional assembly of the outer kinetochore but is unable to correct errors in kinetochore-microtubule attachment in Xenopus egg extracts. We find that CPC has two distinct roles at centromeres: one to selectively phosphorylate Ndc80 to regulate attachment and a second, conserved kinase-independent role in the proper composition of inner kinetochore proteins. Although a fully assembled inner kinetochore is not required for outer kinetochore assembly, we find it is essential to recruit tension indicators, such as BubR1 and 3F3/2, to erroneous attachments. We conclude centromeric CPC is necessary for tension-dependent removal of erroneous attachments and for the kinetochore ...
Local resource for real-ear testing in Aurora, CO. Includes detailed information on local businesses that provide access to real-ear testing, audiologists, hearing loss treatment, tinnitus treatment, and hearing aids, as well as advice and content on hearing loss, conditions of the ear, and hearing problems.
Artificial Intelligence Software Will Help Hospital Manage Medical Staff More Effectively SAN MATEO, CA, October 19, 2010 - Stottler Henke Associates, Inc. today announced that Massachusetts General Hospital will use its Aurora software to schedule clinical rotations, on-call shifts, and clinic hours for its medical residency program. The Aurora software solution will reduce the time and effort needed to generate efficient schedules that support the hospitals complex staffing needs and comply with complex and changing rules and constraints.. As the original and largest teaching hospital of Harvard Medical School, Mass General offers residency programs in more than a dozen clinical departments and interdisciplinary areas. Initially, Aurora will support the hospitals Internal Medicine residency program. Scheduling these residents is complex and labor-intensive because the schedules must satisfy the hospitals staffing requirements, special requests, and clinical rotation rules that ensure that ...
Two closely connected mechanisms safeguard the fidelity of chromosome segregation in eukaryotic cells. The mitotic checkpoint monitors the attachment of kinetochores to microtubules and delays anaphase onset until all sister kinetochores have become attached to opposite poles. In addition, an error correction mechanism destabilizes erroneous attachments that do not lead to tension at sister kinetochores. Aurora B kinase, the catalytic subunit of the CPC (chromosomal passenger complex), acts as a sensor and effector in both pathways. In this review we focus on a poorly understood but important aspect of mitotic control: what prevents the mitotic checkpoint from springing into action when sister centromeres are split and tension is suddenly lost at anaphase onset? Recent work has shown that disjunction of sister chromatids, in principle, engages the mitotic checkpoint, and probably also the error correction mechanism, with potentially catastrophic consequences for cell division. Eukaryotic cells ...
In conclusion, we propose that the mitotic spindle protein She1 functions as an MT cross-linking protein to maintain proper spindle stability during metaphase (Fig. 6 H). There are three major lines of evidence supporting this conclusion: (1) she1-ΔN89 and she1-ΔN126 cells display dynein-independent spindle defects, (2) She1 cross-links MTs in vitro, and (3) the she1-ΔN126 spindle phenotype is complemented by inactivation of Ipl1/Aurora B or by overexpression of she1-ΔN126. The latter shows that premature loading of Ipl1/Aurora B in metaphase inhibits the spindle stabilization effect of she1-ΔN126. Furthermore, we show that this novel activity of She1 is negatively regulated by Ipl1/CPC translocation during anaphase.. Recent work suggested that, during the establishment of a functional metaphase spindle midzone (Hepperla et al., 2014), passive cross-linking proteins are required to maintain proper bundling within the spindle once ipMTs are aligned along the spindle axis by kinesin-14 ...
AURORA , Vintage Theatres production of "August: Osage County" is the very definition of ambitious local theater.. The Pulitzer-Prize-winning play features 13 characters, numerous storylines running parallel to one another and enough family dysfunction to fill a season of a Maury Povich-hosted television show. It takes a herculean effort from cast and crew to make it all work.. The story centers around the Weston clans impromptu reunion after the disappearance of its patriarch Beverly. Their gathering is like several tornadoes of resentment and combative family ties colliding into a perfect storm that leaves nothing standing. Clocking in at three-plus hours, the audience gets the brewing storm, its destructive force and the shell-shocked aftermath.. At its best, Vintages incarnation of "August: Osage County" is the perfect example of why local theater should never shy away from a challenging show. It can make the audience erupt in laughter one moment and then squirm in their seats the next as ...

aurora kinase | PNASaurora kinase | PNAS

Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic ... A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X ... Activation loop phosphorylation of a protein kinase is a molecular marker of organelle size that dynamically reports flagellar ...
more infohttps://www.pnas.org/keyword/aurora-kinase

Aurora kinase B - DrugBankAurora kinase B - DrugBank

Aurora kinase B. Q96GD4. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. Pharmacological action?. ... Aurora kinase B. Kind. protein. Organism. Humans. Polypeptides. Name. UniProt ID. ...
more infohttps://www.drugbank.ca/bio_entities/BE0003404

Aurora Kinase B ELISA Kits | Biocompare.comAurora Kinase B ELISA Kits | Biocompare.com

Compare Aurora Kinase B ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and ... Aurora Kinase B ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for ... Your search returned 58 Aurora Kinase B ELISA ELISA Kit across 7 suppliers. ... Mouse/Human/Rat Phospho-AURKB / Aurora-B (Thr232) ELISA Kit (Cell-Based Phosphorylation ELISA) ...
more infohttps://www.biocompare.com/pfu/110627/soids/2-93946/ELISA_Kit/ELISA_Aurora_Kinase_B

Aurora Kinase InhibitorsAurora Kinase Inhibitors

The human aurora kinase family comprises three members: Aurora A, B and C (AURKA, AURKB and AURKC). Aurora A is important in ... Aurora kinases are a highly conserved family of enzymes which add phospho-groups to Serine/Threonine residues of substrate ... The involvement of these kinases in cell division and deregulated expression of aurora A and B in tumor cells (often resulting ... BioVision proudly offers several aurora kinase inhibitors including the ones mentioned above and more. ...
more infohttps://www.biovision.com/products/signal-transduction/protein-kinases/protein-kinase-inhibitors/aurora-kinase-inhibitors.html

Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways.  - PubMed - NCBIAurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways. - PubMed - NCBI

B kinase with putative anti-tumoral activity. Inhibitors of aurora kinases were shown to induce apoptosis in vitro and in vivo ... Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways.. Li M1, Jung A, Ganswindt U, Marini P, Friedl A ... ZM447439 (ZM) is a potent and selective inhibitor of aurora-A and - ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/19686703?dopt=Abstract

Hesperadin | ≥99%(HPLC) | Selleck | Aurora Kinase inhibitor
		
		
			
				
			
			
				
			
		
		
			
			
				
			
		
		
			
		...Hesperadin | ≥99%(HPLC) | Selleck | Aurora Kinase inhibitor ...

Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. Find all ... The Aurora B kinase assay:. For the Aurora B kinase assay, HeLa cells are lysed in a buffer containing 50 mM NaCl. The whole ... less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. Phase 2. ... Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, ...
more infohttps://www.selleckchem.com/products/Hesperadin.html

Produktübersicht anti-Aurora Kinase C AntikörperProduktübersicht anti-Aurora Kinase C Antikörper

Ausgesuchte Qualitäts-Hersteller für Aurora Kinase C Antikörper. Hier bestellen. ... Monoklonale und polyklonale Aurora Kinase C Antikörper für viele Methoden. ... aurora kinase C , ARK-3 , aurora 3 , aurora-related kinase 3 , aurora/IPL1-related kinase 3 , aurora/IPL1/EG2 protein 2 , ... serine/threonine-protein kinase aurora-C , aurora B , aurora/Ipl1/Eg2 protein 1 , serine/threonine kinase 13 (aurora/IPL-like) ...
more infohttp://www.antikoerper-online.de/zellzyklus-pathway-13/aurora-kinase-c-antibody-6377/

Aurora Kinases as Anticancer Drug Targets | Clinical Cancer ResearchAurora Kinases as Anticancer Drug Targets | Clinical Cancer Research

Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase. FEBS Lett 2005;579:3385-91. ... Aurora-C kinase is a novel chromosomal passenger protein that can complement aurora-B kinase function in mitotic cells. Cell ... Aurora Kinases. The aurora family comprises three related kinases that share the highest degree of sequence homology in their ... that aurora kinases are appropriate drug targets; and that inhibitors of these particular aurora kinases can add to the cancer ...
more infohttp://clincancerres.aacrjournals.org/content/14/6/1639.long

R547 - Aurora Kinases as Druggable Targets in Cancer TherapyR547 - Aurora Kinases as Druggable Targets in Cancer Therapy

Aurora Kinases as Druggable Targets in Cancer Therapy » Blog Archives Menu Not Found. Skip to content *Home ...
more infohttp://www.exposed-skin-care.net/tag/r547/

KILLER - Aurora Kinases as Druggable Targets in Cancer TherapyKILLER - Aurora Kinases as Druggable Targets in Cancer Therapy

Aurora Kinases as Druggable Targets in Cancer Therapy » Blog Archives Menu Not Found. Skip to content *Home ...
more infohttp://www.exposed-skin-care.net/tag/killer/

MLN8054 | Aurora Kinase inhibitor | Read Reviews & Product Use Citations
		
	MLN8054 | Aurora Kinase inhibitor | Read Reviews & Product Use Citations

Aurora A (IC50 = 0.004 uM) over Aurora B (IC50 = 0.172 uM). Find all the information about MLN8054 for cell signaling research. ... Aurora Kinase Inhibitors with Unique Features. * Pan Aurora Kinase Inhibitors. Danusertib (PHA-739358) : Pan-Aurora kinase ... less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. Phase 2. ... Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, ...
more infohttps://www.selleckchem.com/products/MLN8054.html

Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma.  - PubMed - NCBIInhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma. - PubMed - NCBI

... aurora kinase inhibitors as a promising therapeutic option in myeloma can be tailoredly given to patients expressing aurora-A, ... Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma.. Hose D1, Rème T, Meissner T, Moreaux J, ... A1) Inhibition of proliferation of 20 myeloma cell lines by the pan-Aurora-kinase inhibitor VX680 in graded concentrations vs. ... Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/19171872

AURKA Enzyme Human Recombinant | Aurora Kinase A | ProSpecAURKA Enzyme Human Recombinant | Aurora Kinase A | ProSpec

Aurora kinase A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase, Aurora-A, Aurora- ... AURKA (Aurora Kinase A) belongs to the mitotic serine/threonine kinases family. AURKA is a cell cycle-regulated kinase which ... related kinase 1, hARK1, AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6, STK7, STK15, AURORA2, MGC34538. ...
more infohttps://www.prospecbio.com/aurka_human

Aurora Kinase A and Ninein Interacting Protein (AUNIP) AntikörperAurora Kinase A and Ninein Interacting Protein (AUNIP) Antikörper

Weitere Produktkategorien zu Aurora Kinase A and Ninein Interacting Protein Antikörper * 24 anti-Aurora Kinase A and Ninein ... Weitere Antikörper gegen Aurora Kinase A and Ninein Interacting Protein Interaktionspartner. Mouse (Murine) Aurora Kinase A and ... Top anti-Aurora Kinase A and Ninein Interacting Protein Antikörper auf antikoerper-online.de. Showing 10 out of 24 products:. ... Human Aurora Kinase A and Ninein Interacting Protein (AUNIP) Interaktionspartner * AIBp (zeige APOA1BP Antikörper) may not only ...
more infohttps://www.antikoerper-online.de/abstract/Aurora+Kinase+A+and+Ninein+Interacting+Protein+

Millennium Starts Pivotal Trial of Its Aurora Kinase Drug MLN8237 in PTCL | BioWorldMillennium Starts Pivotal Trial of Its Aurora Kinase Drug MLN8237 in PTCL | BioWorld

Aurora kinase inhibition is a new mechanism of action. It helps to create the structure that separates chromosomes in cells, an ... Like most Aurora kinases, those compounds dont distinguish between the A and B forms. According to Niculescu, MLN8237s ... There are no approved Aurora kinases on the market; however, there are others in development, including AT9283 from Cancer ... Millennium Starts Pivotal Trial of Its Aurora Kinase Drug MLN8237 in PTCL ...
more infohttp://www.bioworld.com/content/millennium-starts-pivotal-trial-its-aurora-kinase-drug-mln8237-ptcl

Archive ouverte HAL - Inhibition of Aurora-kinases for tailored risk adapted treatment of multiple myeloma.Archive ouverte HAL - Inhibition of Aurora-kinases for tailored risk adapted treatment of multiple myeloma.

The effect of the clinical Aurora-kinase inhibitor VX680 on proliferation of 20 human-myeloma-cell-lines and survival of 5 ... We found Aurora-A and -B to be expressed at varying frequencies in primary myeloma-cells of different patient-cohorts, Aurora-C ... In conclusion, using gene expression profiling, Aurora-kinase inhibitors as promising therapeutic option for newly-diagnosed ... absent Aurora-A expression show a significantly higher proliferation rate, but neither a higher absolute number of chromosomal ...
more infohttps://hal.archives-ouvertes.fr/inserm-00368414

Aurora kinase - WikipediaAurora kinase - Wikipedia

As mentioned above, there are three classes of aurora kinases: Aurora A (a.k.a. Aurora 2) functions during prophase of mitosis ... Aurora kinases are serine/threonine kinases that are essential for cell proliferation. The enzyme helps the dividing cell ... Aurora inhibitor Bolanos-Garcia V M. Aurora kinases. The International Journal of Biochemistry & Cell Biology 37 (2005) 1572- ... Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. Journal of Cell ...
more infohttps://en.wikipedia.org/wiki/Aurora_kinase

Arabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation | Plant CellArabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation | Plant Cell

2008). Dictyostelium Aurora kinase has properties of both Aurora A and Aurora B kinases. Eukaryot. Cell 7: 894-905. ... 2010). A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells. J. Cell Sci. ... Aurora kinases function as key regulators of mitosis. Yeasts have a single Aurora kinase, whereas metazoans and land plants ... 2009). Aurora-C kinase supports mitotic progression in the absence of Aurora-B. Cell Cycle 8: 2984-2994. ...
more infohttp://www.plantcell.org/content/23/11/4013

Aurora Kinase 2  - 製品情報: Leica BiosystemsAurora Kinase 2 - 製品情報: Leica Biosystems

Aurora Kinase 2, also known as AurkA, STK15, BTAK, ARK1 and AIK1, localizes to interphase and mitotic centrosomes and to the ... Aurora Kinase 1 and 2 encode cell cycle-regulated serine/threonine kinases that are involved in microtubule spindle activities ... Aurora Kinase 2 Primary Antibodies Aurora Kinase 2 Novocastra. *製品情報 ... This suggests that Aurora Kinase 2 can behave as a dominant negative mutant and inhibit other aurora kinases. When inactive ...
more infohttps://www.leicabiosystems.com/jp/ihc-ish-fish/immunohistochemistry-ihc-antibodies-novocastra-reagents/primary-antibodies/products/aurora-kinase-2/

Global Aurora Kinase C Market Research Report 2018 - RnR Market ResearchGlobal Aurora Kinase C Market Research Report 2018 - RnR Market Research

Global Aurora Kinase C Market Research Report 2018 is a market research report available at US $2900 for a Single User PDF ... Aurora Kinase C (Aurora 3 or Aurora/IPL1 Related Kinase 3 or Aurora/IPL1/Eg2 Protein 2 or Serine/Threonine Protein Kinase 13 or ... United States Aurora Kinase C Market Report 2017. United States Aurora Kinase C Market Report 2018. Global Aurora Kinase C ... 1 Aurora Kinase C Market Overview. 1.1 Product Overview and Scope of Aurora Kinase C. 1.2 Aurora Kinase C Segment by Type ( ...
more infohttp://www.rnrmarketresearch.com/global-aurora-kinase-c-market-research-report-2018-market-report.html

Regulation of embryonic and induced pluripotency by aurora kinase-p53 signalingRegulation of embryonic and induced pluripotency by aurora kinase-p53 signaling

... Lee, Dung Fang; Su, Jie; Ang, Yen Sin; ... Depletion of one such molecule, aurora kinase A (Aurka), resulted in compromised self-renewal and consequent differentiation. ... Depletion of one such molecule, aurora kinase A (Aurka), resulted in compromised self-renewal and consequent differentiation. ... Depletion of one such molecule, aurora kinase A (Aurka), resulted in compromised self-renewal and consequent differentiation. ...
more infohttps://lup.lub.lu.se/search/publication/f85d84c7-bfab-43a6-80be-9a348cad9d88

Deregulated Expression of Aurora Kinases Is Not a Prognostic Biomarker in Papillary Thyroid Cancer PatientsDeregulated Expression of Aurora Kinases Is Not a Prognostic Biomarker in Papillary Thyroid Cancer Patients

The data reported here demonstrate that the expression of Aurora kinases is deregulated in the majority of PTC tissues, likely ... In particular, Aurora-A and Aurora-B mRNA levels were altered, respectively, in 55 (63.2%) and 79 (90.8%) out of the 87 PTC ... The analysis of Aurora-A and Aurora-B mRNA levels in PTC tissues, compared to normal matched tissues, revealed that their ... In thyroid cancer tissues a deregulated expression of Aurora kinases has been also demonstrated, butno information regarding ...
more infohttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121514

Phase 1 Study Of Aurora Kinase Inhibitor PF-03814735 In Patients With Advanced Solid Tumors - Tabular View - ClinicalTrials.govPhase 1 Study Of Aurora Kinase Inhibitor PF-03814735 In Patients With Advanced Solid Tumors - Tabular View - ClinicalTrials.gov

Phase 1 Study Of Aurora Kinase Inhibitor PF-03814735 In Patients With Advanced Solid Tumors. The safety and scientific validity ... Phase I, open-label, multicentre, dose-escalation, pharmacokinetic and pharmacodynamic trial of the oral aurora kinase ... Phase 1 Study Of Aurora Kinase Inhibitor PF-03814735 In Patients With Advanced Solid Tumors. ... Pharmacokinetic And Pharmacodynamic Trial Of The Oral Single Agent Aurora Kinase Inhibitor PF-03814735 In Patients With ...
more infohttps://clinicaltrials.gov/ct2/show/record/NCT00424632

Aurora kinase A localises to mitochondria to control organelle dynamics and energy production | eLifeAurora kinase A localises to mitochondria to control organelle dynamics and energy production | eLife

Aurora A kinase negatively regulates Rho-kinase by phosphorylation in vivo * W Moon ... A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma * G Görgün ... Aurora A localizes to the mitochondria during interphase, it is active as a kinase in this organelle, and its depletion results ... Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation * X ...
more infohttps://elifesciences.org/articles/38111

The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo | Molecular Cancer...The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo | Molecular Cancer...

The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Amir Faisal, ... The Aurora kinases regulate key stages of mitosis including centrosome maturation, spindle assembly, chromosome segregation and ... The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo ... The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo ...
more infohttp://mct.aacrjournals.org/content/early/2011/08/31/1535-7163.MCT-11-0333
  • Aurora A expression in tumors is often associated with gene amplification, genetic instability, poor histologic differentiation, and poor prognosis. (aacrjournals.org)
  • Aurora B is frequently expressed at high levels in a variety of tumors, often coincidently with aurora A, and expression level has also been associated with increased genetic instability and clinical outcome. (aacrjournals.org)
  • Hesperadin potently inhibits Aurora B with IC50 of 250 nM in a cell-free assay. (selleckchem.com)
  • Hesperadin inhibits the ability of immunoprecipitated Aurora B to phosphorylate histone H3 with IC50 of 250 nM and markedly reduces the activity of other kinases (AMPK, Lck, MKK1, MAPKAP-K1, CHK1, and PHK) at a concentration of 1 μM. (selleckchem.com)
  • Aurora B activity was inhibited in tumour tissue, but clinical or metabolic antitumour activity was limited. (sigmaaldrich.com)
  • Three Aurora kinases have been identified in mammalian cells to date. (wikipedia.org)
  • Intriguingly, abolishment of Aurora A through RNAi interference results in different mutant phenotypes in different organisms and cell types. (wikipedia.org)
  • Hesperadin and nocodazole treatment in HeLa cells abolishes kinetochore localization of BubR1 and diminishes the intensity of Bub1 at kinetochores, suggesting that Aurora B function is required for efficient kinetochore recruitment of BubR1 and Bub1, which in turn might be necessary for prolonged checkpoint signaling. (selleckchem.com)
  • Shown are the blots of 10 cell lines for Aurora-A and -B with β-actin as loading control and HELA cells as positive control, respectively. (nih.gov)
  • HeLa cell line: immunohistochemical staining for Aurora Kinase using NCL-L-AK2. (leicabiosystems.com)
  • Aurora Kinase 2 is reported to be expressed at high levels in testis and various proliferating cell lines, including HeLa cells. (leicabiosystems.com)
  • Further, aurora kinase gene polymorphisms are associated with increased risk or early onset of cancer. (aacrjournals.org)
  • To validate gene expression data, quantitative real-time PCR for Aurora-A, -B, -C in (A1) 10 myeloma cell lines (HMCL) and (A2) 10 primary myeloma cells (pMMC) was performed. (nih.gov)
  • Here, we characterize a viable double knockdown mutant in Arabidopsis thaliana group α Aurora (AUR) kinases, AUR1 and AUR2 , ( aur1-2 aur2-2 ), with a primary defect in lateral root formation and outgrowth. (plantcell.org)
  • Genetic instability and cellular proliferation have been associated with aurora kinase expression in several cancer entities, including multiple myeloma. (nih.gov)
  • Myeloma cell samples with detectable versus absent aurora-A expression show a significantly higher proliferation rate, but neither a higher absolute number of chromosomal aberrations (aneuploidy), nor of subclonal aberrations (chromosomal instability). (nih.gov)
  • Complementation assays showed that the Arabidopsis α group Aurora kinases are functionally divergent from the single β group member AUR3 and that AUR1 functions in division plane orientation prior to cytokinesis. (plantcell.org)
  • γ-tubulins, the base structure from which centrosomal microtubules polymerize, are also recruited by Aurora A. Without Aurora A the centrosome does not accumulate the quantity of γ-tubulin that normal centrosomes recruit prior to entering anaphase. (wikipedia.org)
  • More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. (wikipedia.org)
  • Therefore, the expression of aurora-A, -B, and -C was determined by Affymetrix DNA microarrays in 784 samples including 2 independent sets of 233 and 345 CD138-purified myeloma cells from previously untreated patients. (nih.gov)
  • Presence of aurora-A expression delineates significantly inferior event-free and overall survival in 2 independent cohorts of patients undergoing high-dose chemotherapy, independent from conventional prognostic factors. (nih.gov)
  • Presence of Aurora-A expression delineates significantly inferior event-free and overall-survival in two independent cohorts of patients undergoing high-dose chemotherapy, independent of conventional prognostic factors, i.e. serum-beta2-microglobulin or ISS-stage. (archives-ouvertes.fr)
  • The expression of aurora C in cancer is less well studied. (aacrjournals.org)
  • C) Intracytoplasmatic expression of Aurora-A and -B as determined by flow cytometry. (nih.gov)
  • In thyroid cancer tissues a deregulated expression of Aurora kinases has been also demonstrated, butno information regarding its possible prognostic role in differentiated thyroid cancer is available. (plos.org)
  • The analysis of Aurora-A and Aurora-B mRNA levels in PTC tissues, compared to normal matched tissues, revealed that their expression was either up- or down-regulatedin the majority of cancer tissues. (plos.org)
  • The expression of both Aurora genes was not affected by the BRAF V600E mutation. (plos.org)
  • Univariate, multivariate and Kaplan-Mayer analyses documented the lack of association between Aurora-A or Aurora-B expression and clinicopathological parameterssuch as gender, age, tumor size, histology, TNM stage, lymph node metastasis and BRAF status as well asdisease recurrences or disease-free interval. (plos.org)
  • Aurora kinases are strongly expressed in a broad range of cancer types. (aacrjournals.org)
  • A recent study shows that MLN8054 sensitizes androgen-resistant prostate cancer to radiation by inhibiting Aurora A kinase, which is associated with sustained DNA double-strand breaks. (selleckchem.com)