Aurora Kinase C
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. They are involved in many aspects of cell division, including centrosome duplication, SPINDLE APPARATUS formation, chromosome alignment, attachment to the spindle, checkpoint activation, and CYTOKINESIS.
Aurora Kinase A
Aurora Kinase B
Protein Kinase C
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. (1/30)Our previous studies showed that Aie1 (aurora-C), is a novel testis kinase belonging to the aurora kinase family (). In this report, we describe a testis zinc finger protein (Tzfp) that binds to the upstream flanking sequence of the Aie1 gene. The mouse Tzfp gene, mapped to chromosome 7 B2-B3, encodes a 465-amino acid transcription factor containing a conserved N-terminal BTB/POZ domain and three C-terminal PLZF-like C(2)H(2) zinc fingers. The zinc finger domain of Tzfp binds to the TGTACAGTGT motif (Tzfp binding site, termed tbs) located at the upstream flanking sequence of the Aie1 gene by gel mobility shift, DNase I footprinting, and competition analyses. When the C-terminal zinc fingers of Tzfp were fused to the transactivation domain of VP16, the chimera activated transcription of a reporter construct containing multiple copies of the tbs. In contrast, the same chimera did not activate the reporter gene when an essential nucleotide fifth C was mutated to A at the tbs. Furthermore, we showed that the N-terminal BTB/POZ domain of TZFP has a repressor activity. Taken together, our results indicate that Tzfp recognizes a sequence-specific motif (tbs) and may play a role in the regulation of the genes carrying the tbs. (+info)
On the role of aurora-A in centrosome function. (2/30)Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. Works in various organisms have revealed that the kinase is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability. Aurora kinases are found in all organisms in which their function has been conserved throughout evolution, namely the control of chromosome segregation. In human, aurora-A has focused a lot of attention, since its overexpression has been found to be correlated with the grade of various solid tumours. Ectopic kinase overexpression in any culture cell line leads to polyploidy and centrosome amplification. However, overexpression of aurora-A in particular cell lines such as NIH3T3 is sufficient to induce growth on soft agar. Those transformed cells form tumours when implanted in immunodeficient mice, indicating that the kinase is an oncogene. (+info)
Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. (3/30)A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. The human Aurora paralogues Aurora-A, Aurora-B, and Aurora-C have a highly conserved catalytic domain. Extensive studies on the role of Aurora-A and Aurora-B have revealed distinct localizations and functions in regulating mitotic processes, whereas little is known about Aurora-C. The present study shows that human Aurora-C is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), which are known passenger proteins. We show that INCENP binds and activates Aurora-C in vivo and in vitro. Furthermore, Aurora-C co-expressed with INCENP elicits the phosphorylation of endogenous histone H3 in mammalian cells, even though this phosphorylation is not sufficient to establish chromosome condensation in interphase cells. We therefore suggest that Aurora-C is a novel chromosomal passenger protein that cooperates with Aurora-B to regulate mitotic chromosome dynamics in mammalian cells. (+info)
Evolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugs. (4/30)BACKGROUND: As key regulators of mitotic chromosome segregation, the Aurora family of serine/threonine kinases play an important role in cell division. Abnormalities in Aurora kinases have been strongly linked with cancer, which has lead to the recent development of new classes of anti-cancer drugs that specifically target the ATP-binding domain of these kinases. From an evolutionary perspective, the species distribution of the Aurora kinase family is complex. Mammals uniquely have three Aurora kinases, Aurora-A, Aurora-B, and Aurora-C, while for other metazoans, including the frog, fruitfly and nematode, only Aurora-A and Aurora-B kinases are known. The fungi have a single Aurora-like homolog. Based on the tacit assumption of orthology to human counterparts, model organism studies have been central to the functional characterization of Aurora kinases. However, the ortholog and paralog relationships of these kinases across various species have not been rigorously examined. Here, we present comprehensive evolutionary analyses of the Aurora kinase family. RESULTS: Phylogenetic trees suggest that all three vertebrate Auroras evolved from a single urochordate ancestor. Specifically, Aurora-A is an orthologous lineage in cold-blooded vertebrates and mammals, while structurally similar Aurora-B and Aurora-C evolved more recently in mammals from a duplication of an ancestral Aurora-B/C gene found in cold-blooded vertebrates. All so-called Aurora-A and Aurora-B kinases of non-chordates are ancestral to the clade of chordate Auroras and, therefore, are not strictly orthologous to vertebrate counterparts. Comparisons of human Aurora-B and Aurora-C sequences to the resolved 3D structure of human Aurora-A lends further support to the evolutionary scenario that vertebrate Aurora-B and Aurora-C are closely related paralogs. Of the 26 residues lining the ATP-binding active site, only three were variant and all were specific to Aurora-A. CONCLUSIONS: In this study, we found that invertebrate Aurora-A and Aurora-B kinases are highly divergent protein families from their chordate counterparts. Furthermore, while the Aurora-A family is ubiquitous among all vertebrates, the Aurora-B and Aurora-C families in humans arose from a gene duplication event in mammals. These findings show the importance of understanding evolutionary relationships in the interpretation and transference of knowledge from studies of model organism systems to human cellular biology. In addition, given the important role of Aurora kinases in cancer, evolutionary analysis and comparisons of ATP-binding domains suggest a rationale for designing dual action anti-tumor drugs that inhibit both Aurora-B and Aurora-C kinases. (+info)
Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. (5/30)Human Aurora kinases have three gene family members: Aurora-A, Aurora-B, and Aurora-C. It is not yet established what the specificity of these kinases are and what signals relayed by their reactions. Therefore, we employed small pool expression screening to search for downstream substrates of Aurora-A. Interestingly, all of the identified Aurora-A substrates were resistant to serve as substrates for Aurora-B or Aurora-C, suggesting that these Aurora family members may have distinct substrate specificity for propagation of diverse signaling pathways, even though they share a conserved catalytic kinase domain. Of the candidate substrates, Aurora-A could increase the functional activity of RalA. Mutational analysis revealed that RalA-Ser194 was the phosphorylation site for Aurora-A. Ectopic expression of V23RalA-WT could enhance collagen I-induced cell migration and anchorage-independent growth in Madin-Darby canine kidney (MDCK) Aurora-A stable cell lines. In contrast, overexpression of V23RalA-S194A in MDCK Aurora-A-stable cell lines abolished the intrinsic migration and transformation abilities of Aurora-A. To our knowledge, this is the first systematic search for the downstream substrates of Aurora-A kinase. Moreover, these results support the notion that Aurora-A may act in concert with V23RalA through protein phosphorylation on Ser194 to promote collagen I-induced cell motility and anchorage-independent growth in MDCK epithelial cells. (+info)
The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression. (6/30)Aurora-C is the third member of the aurora serine/threonine kinase family and was found only in mammals. Because Aurora-C is overexpressed in many different types of cancer cells we decided to analyze the consequences of Aurora-C overexpression in human cells. We first investigated the subcellular localization of overexpressed GFP-Aurora-C in mitosis and interphase in HeLa cells. As expected, during mitosis, we found that Aurora-C mimics Aurora-B. Surprisingly, in few interphase cells, we found that Aurora-C localized to the centrosome, like Aurora-A. We then examined the phenotype generated by Aurora-C overexpression. Basically it looked similar to the phenotypes observed after overexpression of the other Aurora kinases. We observed an augmentation of polyploid cells containing more than two centrosomes. More interestingly this phenotype was aggravated in the absence of a functional p53. Although the physiological function of Aurora-C in somatic cells remains to be clarified, our results, just like for the two other Aurora kinases, raised the question of a role of Aurora-C in the development and progression of cancer especially in the presence of mutated p53. (+info)
Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis. (7/30)Aurora-C was first identified during screening for kinases expressed in mouse sperm and eggs. Herein, we report for the first time the precise subcellular localization of endogenous Aurora-C during male meiotic division. The localization of Aurora-C was analyzed by immunofluorescence staining on chromosome spreads of mouse spermatocytes or in squashed seminiferous tubules. Aurora-C was first detected at clusters of chromocenters in diplotene spermatocytes and was concentrated at centromeres in metaphase I and II. Interestingly, Aurora-C was also found along the chromosome axes, including both the regions of centromeres and the chromosome arms in diakinesis. During the anaphase I/telophase I and anaphase II/telophase II transitions, Aurora-C was relocalized to the spindle midzone and midbody. A similar distribution pattern was also observed for Aurora-B during male meiotic divisions. Surprisingly, we detected no Aurora-C in mitotic spermatogonia. Furthermore, immunoprecipitation analyses revealed that INCENP associated with Aurora-C in the male testis. We propose that INCENP recruits Aurora-C (or some other factor(s) recruit INCENP and Aurora-C) to meiotic chromosomes, while Aurora-C may either work alone or cooperate with Aurora-B to regulate chromosome segregation during male meiosis. (+info)
The human cumulus--oocyte complex gene-expression profile. (8/30)BACKGROUND: The understanding of the mechanisms regulating human oocyte maturation is still rudimentary. We have identified transcripts differentially expressed between immature and mature oocytes and cumulus cells. METHODS: Using oligonucleotide microarrays, genome-wide gene expression was studied in pooled immature and mature oocytes or cumulus cells from patients who underwent IVF. RESULTS: In addition to known genes, such as DAZL, BMP15 or GDF9, oocytes up-regulated 1514 genes. We show that PTTG3 and AURKC are respectively the securin and the Aurora kinase preferentially expressed during oocyte meiosis. Strikingly, oocytes overexpressed previously unreported growth factors such as TNFSF13/APRIL, FGF9, FGF14 and IL4 and transcription factors including OTX2, SOX15 and SOX30. Conversely, cumulus cells, in addition to known genes such as LHCGR or BMPR2, overexpressed cell-to-cell signalling genes including TNFSF11/RANKL, numerous complement components, semaphorins (SEMA3A, SEMA6A and SEMA6D) and CD genes such as CD200. We also identified 52 genes progressively increasing during oocyte maturation, including CDC25A and SOCS7. CONCLUSION: The identification of genes that were up- and down-regulated during oocyte maturation greatly improves our understanding of oocyte biology and will provide new markers that signal viable and competent oocytes. Furthermore, genes found expressed in cumulus cells are potential markers of granulosa cell tumours. (+info)
... there are three classes of aurora kinases in multicellular organisms, including humans: Aurora A (a.k.a. Aurora 2) functions ... Aurora kinases are serine/threonine kinases that are essential for cell proliferation. They are phosphotransferase enzymes that ... Aurora inhibitor Bolanos-Garcia V M. Aurora kinases. The International Journal of Biochemistry & Cell Biology 37 (2005) 1572- ... Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. Journal of Cell ...
Aurora kinase B
Aurora kinase Aurora A kinase Aurora C kinase INCENP Spindle assembly checkpoint GRCh38: Ensembl release 89: ENSG00000178999 - ... Phosphorylation of CENP-A at serine 7 by Aurora A kinase recruits Aurora B to the centromere. Aurora B, itself, can also ... The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to ... Aurora B kinase has been shown to interact with: BARD1, BIRC5, and CDCA8 TACC1. FBXL2. Abnormally elevated levels of Aurora B ...
Aurora kinase C
Although yeast contain only one Aurora kinase and C. elegans and Drosophila contain only two, mammals have three Aurora kinases ... "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells". Cell ... "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells". Cell ... Aurora kinase C, also Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene. This gene ...
Aurora kinase A
The human genome contains three members of the aurora kinase family: Aurora kinase A, Aurora kinase B and Aurora C kinase. The ... Aurora A and Aurora B kinases play important roles in mitosis. The Aurora kinase A is associated with centrosome maturation and ... Aurora A phosphorylation directs the cytoplasmic polyadenylation translation of mRNA's, like the MAP kinase kinase kinase ... contain orthologues only to Aurora A and Aurora B. In all studied species, the three Aurora mitotic kinases localize to the ...
Aurora kinase inhibitors are a putative drug class for treating cancer. The Aurora kinase enzymes could be potential targets ... There are three mammalian aurora kinase genes, encoding aurora A, B and C. Intense investigation has focused on aurora A and B ... Aurora-B (Serine/threonine-protein kinase 12, AIK2, AIM1, ARK2, STK12) Aurora-C (Serine/threonine-protein kinase 13, AIE2, AIK3 ... Aurora kinases, so named because the scattered mitotic spindles generated by mutant forms resemble the Aurora Borealis, have ...
... works as an inhibitor, attaching to the active sites of Aurora A and Aurora B kinases. Hauf, Silke; Cole, Richard W ... Hesperadin is an aurora kinase inhibitor. The small molecule inhibits chromosome alignment and segregation by limiting the ... function of mitotic kinases Aurora B and Aurora A. Hesperadin causes cells to enter anaphase much faster, sometimes before the ... Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms". Molecular Microbiology. 72 (2): 442- ...
This process is associated with Aurora B Protein Kinase. When Aurora B's function is disrupted, MCAK ability to locate ... Andrews PD, Ovechkina Y, Morrice N, Wagenbach M, Duncan K, Wordeman L, Swedlow JR (February 2004). "Aurora B regulates MCAK at ... There are other environments in which MCAK's function is impaired, absent impact on its associated kinase. For example, alpha- ...
"Cyclin Dependent Kinase (CDK) and Aurora Kinase (AK) inhibitors , Cyclacel R&D for anticancer drugs acting on cell cycle". www. ...
... strong interest has shifted towards the aurora kinase proteins. The kinase gene Aurora A when amplified acts as an oncogene ... The localization of MAD2 and BubR1 to the kinetochore may also be dependent on the Aurora B kinase. Cells lacking Aurora B fail ... Aurora-B/Ipl1 kinase of the chromosomal passenger complex functions as the tensions sensor in improper kinetochore attachments ... The Aurora-B/Ipl1 kinase is also critical in correcting merotelic attachments, where one kinetochore is simultaneously attached ...
Midbody (cell biology)
MKLP1 TEX14 CEP55 Aurora Kinase B Paweletz N (January 2001). "Walther Flemming: pioneer of mitosis research". Nature Reviews. ...
"NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of ... Interaction of NEDD9 with Aurora A kinase may also play a role in tumor invasion. NEDD9 binds to and regulates acetylation of ... NEDD9 binds directly to the Aurora-A mitotic kinase at the centrosome, and promotes its activity, allowing cells to enter ... Other phosphorylation events in this region are imposed by the kinase Aurora-A, which phosphorylates residue S296, for ...
Other kinases that have interested Sebti include Rho-associated kinase and Aurora kinase. STAT3. In 2003 the Sebti lab ... May 30, 2014). "Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation". Oncotarget. 5 (10): ... Kinases. Sebti's work on the kinase Akt led to his interest in Triciribine. ... October 1, 2012). "RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor ...
Aurora kinase has two forms which are designated Aurora kinase A and Aurora kinase B. These proteins play a key role in mitosis ... In some human cancers, the expression and kinase activity of Aurora kinases have been up-regulated and has been looked into as ... A possible causes of multipolar spindle formation involve regulation of protein kinase family known as Aurora kinase. ... Jingyan Fu, Fu (26 January 2007). "Roles of Aurora Kinases in Mitosis and Tumorigenesis". Molecular Cancer Research. 5 (1): 1- ...
The CAS family member NEDD9 has also been shown to interact directly with AURKA (encoding Aurora-A kinase) to regulate cell ... it is possible that CASS4 may similarly interact with aurora-A kinase. CASS4 signaling may contribute to platelet activation ... "The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome". Nature ... These include association with FAK and Src family kinases at focal adhesions to transmit integrin-initiated signals to ...
"Drugging MYCN through an Allosteric Transition in Aurora Kinase A." Cancer Cell. 26 (3): 414-27. doi:10.1016/j.ccr.2014.07.015 ... N-Myc is also stabilized by aurora A which protects it from degradation. Drugs that target this interaction are under ... development, and are designed to change the conformation of aurora A. Conformational change in Aurora A leads to release of N- ... "Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma". Cancer Cell. 15 (1): 67-78. doi:10.1016/j. ...
Aurora B is a kinase active in late metaphase, and has been shown to function as a checkpoint for the proper attachments of ... Cimini, Daniela; Wan, Xiaohu; Hirel, Christophe B.; Salmon, E.D. (2006-09-05). "Aurora Kinase Promotes Turnover of Kinetochore ... When Aurora B was partially inhibited by a small molecule drug, Cimini et al. observed lagging chromatids at increasing ... "The Ska complex promotes Aurora B activity to ensure chromosome biorientation". The Journal of Cell Biology. 215 (1): 77-93. ...
"Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcinoma". Anticancer Research. 26 (5A): 3585-93 ...
... is also important in activating and recruiting Aurora A kinase, a kinase responsible for phosphorylating TPX2 and ... In the presence of nuclear import factor importin α, TPX2 is bound and prevented from binding Aurora A kinase, though it is ... TPX2 recruits and activates Aurora A kinase by utilizing its short 43 amino acid long amino-terminal sequence to bind the ... Notably, this recognition between TPX2 and Aurora A is analogous to that between the cAMP-dependent protein kinase (cAPK) ...
"Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells". J. Biol. Chem. 278 (1): 486-90. doi:10.1074/ ... Survivin has been shown to interact with: Aurora B kinase, CDCA8, Caspase 3, Caspase 7, Diablo homolog and INCENP. GRCh38: ...
Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase. Expression of DGL7 is found in cancer and stem ... 2005). "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A". Mol. ... Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY (July 2005). "Phosphorylation and stabilization of HURP by Aurora-A: ... implication of HURP as a transforming target of Aurora-A". Mol. Cell. Biol. 25 (14): 5789-800. doi:10.1128/MCB.25.14.5789- ...
2005). "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase". Genes Cells. 9 (5): 383-97. doi:10.1111/ ... 2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene. 24 (12): 2076-86. doi: ... Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene. This gene encodes a serine/ ... It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle ...
... has been shown to interact with INCENP, Survivin and Aurora B kinase. GRCh38: Ensembl release 89: ENSG00000134690 - ... "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung ...
Aurora kinases are required for proper spindle assembly and separation. Aurora A associates with centrosomes and is believed to ... Spindle assembly is largely regulated by phosphorylation events catalyzed by mitotic kinases. Cyclin dependent kinase complexes ... with many of these proteins serving as Aurora and Polo-like kinase substrates. In a properly formed mitotic spindle, bi- ... Polo-like kinase, also known as PLK, especially PLK1 has important roles in the spindle maintenance by regulating microtubule ...
"Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore". J. Biol. Chem. 283 (39): ...
... has been shown to interact with: Aurora A kinase, CD29 NME3, Protein SET, RAR-related orphan receptor alpha, RAR-related ... "The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1". Nucleic Acids Res. 30 (24): 5465-75 ... Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. It is thought to be a metastasis ... Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) ...
Mir-17 microRNA precursor family
He S, Yang S, Deng G, Liu M, Zhu H, Zhang W, Yan S, Quan L, Bai J, Xu N (2010). "Aurora kinase A induces miR-17-92 cluster ... "miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat ...
... (MLN8237) is an orally available selective aurora A kinase inhibitor developed by Takeda. It was investigated as a ... a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas". Journal of ... Protein kinase inhibitors, Benzoic acids, Fluoroarenes, Abandoned drugs, Takeda Pharmaceutical Company brands, Chloroarenes, ...
"Arabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation". The Plant Cell. 23 (11): 4013-4024. doi: ... Another midline-localized protein, "two-in-on" (TIO), is a putative kinase and is also required for cytokinesis as shown by ... Oh, Sung Aeong; Bourdon, Valérie; Dickinson, Hugh G.; Twell, David; Park, Soon Ki (2014-03-01). "Arabidopsis Fused kinase TWO- ... The essential mechanism of MAPK cascade for phragmoplast expansion is suppressed by cyclin dependent kinase (CDK) activity ...
G2-M DNA damage checkpoint
"Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry". Science. 320 (5883): 1655-1658 ... This loop is further amplified indirectly through the coordinated interaction of the Aurora A kinase and the Bora cofactor. ... pathways which activate the Chk2 and Chk1 kinases, respectively. These kinases act upstream of Cdc25 and Wee1, the direct ... The main rad3 effector is the kinase Chk1, which is required for the G2-M arrest in response to DNA-damaging agents. Chk1 is an ...
Cell cycle checkpoint
Seki A, Coppinger JA, Jang CY, Yates JR, Fang G (June 2008). "Bora and the kinase Aurora a cooperatively activate the kinase ... These kinases phosphorylate and activate the effector kinases Chk2 and Chk1, respectively, which in turn phosphorylate the ... The G1 phase cyclin-dependent kinase works together with S phase cyclin-dependent kinase targeting p27 for degradation. In turn ... The cell is once more examined for sites of DNA damage or incomplete replication, and the kinases ATR and ATM are recruited to ...
... and for his contributions to the understanding of the role of the kinase Aurora B, Mps1 and Haspin in mitosis. In 2008, the ... Santaguida, S; Vernieri, C; Villa, F; Ciliberto, A; Musacchio, A (Apr 20, 2011). "Evidence that Aurora B is implicated in ... "Mechanism of Aurora B activation by INCENP and inhibition by hesperadin". Molecular Cell. 18 (3): 379-91. doi:10.1016/j.molcel. ... "A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B." (PDF). The Journal of Cell Biology. 199 (2 ...
Wirtz-Peitz F, Nishimura T, Knoblich JA (October 2008). "Linking cell cycle to asymmetric division: Aurora-A phosphorylates the ... 1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". ... atypical protein kinase C). In the sensory organ precursor (SOP) cell, the PAR proteins localize to the posterior pole of the ...
Shugoshin N terminal protein domain
Shugoshin is a crucial target of Bub1 kinase that plays a central role in the cohesion of chromosomes during cell division. The ... "Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres". Genes Dev. 21 (4): 420-35. ...
Aurora, R; Rose GD (1998). "Helix Capping". Protein Science. 7 (1): 21-38. doi:10.1002/pro.5560070103. PMC 2143812. PMID ... SPXX or STXX are frequently found at DNA-binding sites and also that they are recognized as substrates by some protein kinases ...
Kinesin-like protein KIF11
Bishop JD, Han Z, Schumacher JM (2005). "The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for ... Rapley J, Nicolas M, Groen A, Regue L, Bertran MT, Caelles C, Avruch J, Roig J (2008). "The NIMA-family kinase Nek6 ... Blangy A, Arnaud L, Nigg EA (1997). "Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor ... "Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase". J Biol Chem. 283 ...
Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN (2008). "The endothelial- ... suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon ...
Alegado, Rosanna A.; Chin, Chui-Yoke; Monack, Denise M.; Tan, Man-Wah (October 2011). "The two-component sensor kinase KdpD is ... Kahanamoku, Sara; Alegado, Rosie 'Anolani; Kagawa-Viviani, Aurora; Kamelamela, Katie Leimomi; Kamai, Brittany; Walkowicz, ...
... and Aurora kinases are responsible for this phosphorylation.  The phosphorylation of downstream targets of Plks and Aurora ... "Figure 1". Aurora-A: the maker and breaker of spindle poles. Journal of Cell Science. Archived from the original on 11 May 2012 ... "CDK2 cyclin dependent kinase 2 [Homo sapiens (human)]". Gene - NCBI. Retrieved 1 December 2019. Hinchcliffe EH, Li C, Thompson ... The mis-expression of genes such as p53, BRCA1, Mdm2, Aurora-A and survivin causes an increase in the amount of centrosomes ...
The centralspindlin cluster formation is promoted by phosphorylation of MLKP1 by Aurora B, a component of CPC. In short, the ... Petronczki M, Glotzer M, Kraut N, Peters JM (May 2007). "Polo-like kinase 1 triggers the initiation of cytokinesis in human ... Second, RhoA promotes myosin II activation by the kinase ROCK, which activates myosin II directly by phosphorylation of the ...
Aurora C, Aurora B, CaMKKβ. The inhibition of these kinases in biochemical reactions in vitro does not necessarily indicate ... SU6656 was initially identified as a Src kinase inhibitor by virtue of its ability to reverse an effect that an activated ... SU6656 has been used primarily as a research tool to investigate the function of Src family kinases in cellular signal ... SU6656 is a Src family kinase inhibitor developed by the biotechnology company SUGEN Inc (a subsidiary of Pharmacia) in 2000. ...
... role in the spindle checkpoint during mitosis thus interacts with spindle assembly proteins Aurora A kinase and Aurora B kinase ... Checkpoint kinases (Chks) are protein kinases that are involved in cell cycle control. Two checkpoint kinase subtypes have been ... WEE1 kinase and PLK1 are also targeted by Chk1 to induce cell cycle arrest. Phosphorylation of WEE1 kinase inhibits cdk1 which ... Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by ...
Claire E. Eyers
Byrne DP, Vonderach M, Ferries S, Brownridge PJ, Eyers CE, Eyers PA (2016). "cAMP-dependent protein kinase (PKA) complexes ... "Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by ... protein kinase complexes and glycan conformation, and several highly-accessed reviews on the subject of ion ... at the University of Dundee where she was awarded a PhD in 2002 for her work on stress-activated protein kinases with Sir ...
Aurora B kinase, and kinesin-8". The Journal of Cell Biology. 191 (4): 795-808. doi:10.1083/jcb.201006028. PMC 2983061. PMID ... The phosphorylation of the protein targets of M-Cdks (Mitotic Cyclin-dependent Kinases) drives spindle assembly, chromosome ... Telophase is primarily driven by the dephosphorylation of mitotic cyclin-dependent kinase (Cdk) substrates. ... microtubule-stabilizer-specific kinases, and plus-end directed microtubule depolymerases, respectively. These effectors are ...
This led to genetic studies that allowed him to discover and name the Polo and Aurora protein kinases, required for the ... In Cambridge he discovered the second main Aurora B kinase required for cells to progress through metaphase and used genetic ... Over the past decade he has uncovered the major steps of centriole duplication by demonstrating that Polo-like-kinase 4 (Plk4) ... Remarkably, the localisation and function of Polo kinase at the centrosome, the kinetochore and the central spindle in ...
He discovered the "chromosomal passenger complex" of INCENP, Aurora B kinase, Survivin and Borealin - a major regulator of ...
Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment. JUB (gene) has been ... Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H (2003). "Aurora-A and an interacting ... Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2 ... Protein Ajuba Influences Interleukin-1-Induced NF-κB Activation by Affecting the Assembly and Activity of the Protein Kinase Cζ ...
Bcr-Abl tyrosine-kinase inhibitor
Unlike other T315I targeting inhibitors in development, ponatinib does not target Aurora kinases, which clearly distinguishes ... At first it was believed that bosutinib was a selective Src kinase inhibitor but now it is known that its kinase inhibition ... Since dasatinib is an inhibitor of Src family kinases, it can overcome resistance due to Src family kinase activation. Because ... particularly the Src family kinases. The Src family kinases have been implicated in Bcr-Abl signaling and mediate imatinib ...
"Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation". Nature Cell Biology. ... "14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective ...
... wanted to apply Aurora's assay expertise to its programs in kinase inhibitors and caspase inhibitors, and wanted access to ... which created Aurora Discovery from it. Aurora Discovery eventually changed its name to Aurora Biotechnologies, and in 2009 was ... In 2001, Aurora was acquired by Vertex Pharmaceuticals for $592 million in stock. Vertex wanted access to Aurora's insight into ... Vertex retained Aurora's drug discovery facility and staff in San Diego; ivacaftor was discovered there in 2005. "Aurora ...
Garikapati Narahari Sastry
Badrinarayan, Preethi; Sastry, G. Narahari (2014). "Specificity Rendering 'Hot-Spots' for Aurora Kinase Inhibitor Design: The ... Badrinarayan, Preethi; Sastry, G. Narahari (2011). "Sequence, Structure, and Active Site Analyses of p38 MAP Kinase: Exploiting ...
... a new interaction partner for human serine/threonine kinase aurora-B". Biochemical and Biophysical Research Communications. 336 ...
Guangzhou is | Aurora kinase B
Aurora kinase members of the family are highly connected and cons | Her2 Signaling
Aurora kinase family members are really related and conserved serine threonine kinases very important for proliferating cells ... Danusertib , a potent inhibitor of all Aurora kinases, would be the very first Aurora inhibitor which entered the clinic . In ... Aurora kinase members of the family are highly connected and cons. Posted on April 28, 2013. by her26451 ... Like a complementary method PI3K Inhibitors to monitoring inhibition of Aurora A and B kinase exercise by Western blot, we ...
Background & seeks Chronic liver disease is characterized by fibrosis that - The Aurora Kinases in Cancer therapy
Background & seeks Chronic liver disease is characterized by fibrosis that may progress to cirrhosis. Results Nod2 deficiency protected mice from cholestatic but not toxin-induced liver injury and fibrosis. Most notably the hepatic bile acid concentration was lower in Nod2?/? mice than wild type mice following bile duct ligation for Rabbit polyclonal to APE1. 3 weeks. In contrast to wild type mice Nod2?/? mice had increased urinary excretion of bile acids including sulfated bile acids and an upregulation of the bile acid efflux Glycitein transporters MRP2 and MRP4 in tubular epithelial cells of the kidney. MRP2 and MRP4 were downregulated by IL-1β Glycitein in a Nod2 dependent fashion. Conclusions Our findings indicate that Nod2 deficiency protects mice from cholestatic liver injury and fibrosis through enhancing renal excretion of bile acids that in turn contributes to decreased concentration of bile acids in the hepatocyte. results IL-1β treatment resulted in a marked reduction of MRP2 and ...
Philip William Jordan, Ph.D., Joint Appointment in Cell Biology | Johns Hopkins Medicine
Wellard S, Schindler K and Jordan PW (2020) Aurora B and Aurora C kinases regulate synaptonemal complex disassembly in male ... Meiosis; Structural maintenance of chromosomes; SMC5; SMC6;Polo-like kinase; PLK; Aurora kinase; AURK; Chromosome segregation; ... kinases and Aurora kinases. We use mouse as a model organism to study consequences of gene mutation and chromosome ... Our lab studies the importance of Structural Maintenance of Chromosomes (SMC) complexes and cell cycle kinases, particularly ...
Myc, Aurora Kinase A, and mutant p53 <sup>R172H</sup> co-operate in a mouse model of metastatic skin...
Myc, Aurora Kinase A, and mutant p53 R172H co-operate in a mouse model of metastatic skin carcinoma. / Torchia, E. C.; Caulin, ... Myc, Aurora Kinase A, and mutant p53 R172H co-operate in a mouse model of metastatic skin carcinoma. Oncogene. 2012 May;31(21): ... Myc, Aurora Kinase A, and mutant p53 R172H co-operate in a mouse model of metastatic skin carcinoma. In: Oncogene. 2012 ; Vol. ... Torchia, E. C., Caulin, C., Acin, S., Terzian, T., Kubick, B. J., Box, N. F., & Roop, D. R. (2012). Myc, Aurora Kinase A, and ...
... aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora- and Ipl1-like midbody-associated protein 1; aurora-1; aurora ... aurora-related kinase 2; aurora/IPL1-related kinase 2; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12 ... serine/threonine-protein kinase aurora-B. Background. This gene encodes a member of the aurora kinase subfamily of serine/ ... aurora kinase B (AURKB). Target Class. Kinase. Family. Other. Official Symbol. AURKB. Entrez Gene ID. 9212. Species. Human. ...
AURKC gene: MedlinePlus Genetics
The AURKC gene provides instructions for making a protein called aurora kinase C. Learn about this gene and related health ... The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population. Hum Mol ... Aurora kinase C helps the two dividing cells separate from each other and ensures that these cells each contain a complete set ... A lack of aurora kinase C blocks cell division in sperm cells. As a result, sperm cells have extra chromosomes, usually four ...
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein | eLife
The structural basis of the multi-step allosteric activation of Aurora B kinase Dario Segura-Peña, Oda Hovet ... Nikolina ... The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not ... The structural basis of the multi-step allosteric activation of Aurora B kinase ... Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. ...
Indole-5-carboxaldehyde 98 1196-69-6
Scott Nicholas Furlan, MD
Publications 2016 | FAMRI
Aurora kinase targeting in lung cancer reduces KRAS-induced transformation. Mol Cancer. 2016;15:12. ... Gefitinib, an EGFR Tyrosine Kinase inhibitor, Prevents Smoke-Mediated Ciliated Airway Epithelial Cell Loss and Promotes Their ... A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma. Sci Rep. 2016;6 ... activated kinase 6 (PAK6) in non-small cell lung cancer cells. Oncotarget. 2016;7(38):61229-61245. ...
The canonical α-SNAP is essential for gametophytic... | proLékaře.cz
Článek Aurora kinase A is essential for meiosis in mouse oocytes Článek Pathways and signatures of mutagenesis at targeted DNA ... 7. Takatsuka H, Umeda-Hara C, Umeda M (2015) Cyclin-dependent kinase-activating kinases CDKD;1 and CDKD;3 are essential for ... 2018) AGC1.5 Kinase Phosphorylates RopGEFs to Control Pollen Tube Growth. Molecular Plant 11: 1198-1209. doi: 10.1016/j.molp. ... 2008) Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic ...
Active Research Projects
The Rockefeller University » Paul Nurse
... and another that inhibits Aurora protein kinase. The latter compound has been used to demonstrate that the various functions of ... his studies have led to the co-discovery of cyclin-dependent kinase as the key regulator molecule controlling S phase and ... this kinase are triggered by different levels of activity. More recently, the researchers identified a drug inhibiting the AAA+ ...
Germ Cell Determinant Transmission, Segregation, and Function in the Zebrafish Embryo | IntechOpen
Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules - Kölner UniversitätsPublikationsServer
UBASH3B interacts with ubiquitylated Aurora B, one of the main kinases regulating chromosome segregation, and controls its ... Importantly, targeting Aurora B to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation ... Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules. Dev. Cell, 36 (1). S. 63 - 79. ... UBASH3B is a limiting factor in this pathway and is sufficient to localize Aurora B to microtubules prior to anaphase. ...
SMC4 Antibody (NBP1-86635): Novus Biologicals
Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint | Biology Open | The Company of...
Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe ... and Aurora B activation (Wang et al., 2010). The CPC consists of Aurora B kinase and its regulatory proteins, Survivin, INCENP ... Direct inhibition of SAC kinases, such as MPS1 (Santaguida et al., 2010), Aurora B (Hauf et al., 2003; Santaguida et al., 2011 ... Cell-Cycle, PLK1, Aurora B, MPS1, Haspin, Spindle assembly checkpoint, Kinase inhibitors ...
AdipoGen Life Sciences
Novel Inhibitor of Aurora A Kinase. Tripolin B. Anticancer and Trypanocidal Compound. Asperphenamate ... Tumor-specific Pyruvate Kinase M2 Inhibitor Shikonin. NEW Potent Netrin-1 Blocking Antibody anti-Netrin-1 (human), mAb (rec.) ( ... Potent FLT3 Tyrosine Kinase Inhibitor. Sunitinib Malate - BULK Available!. New Human APRIL Blocking Antibody. anti-APRIL (human ... Potent Antiproliferative Multi-kinase Inhibitor Jak/Src Inhibitor 1 [Debio 0617B] . hydrochloride. ...
New Gene Therapy Developed That Could Be Effective Against Many Types of Cancer
Dynamics of Fundamental Cellular Processes by Live Cell and Tissue Imaging - Research Outputs - Discovery - the University...
FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning. Fulcher, L. J., He, Z., Mei, L., ... Aurora B switches relative strength of kinetochore-microtubule attachment modes for error correction. Doodhi, H., Kasciukovic, ... The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms. Fulcher, L., Bozatzi, P., Tachie-Menson, T., Wu, K ...
Immunohistochemistry - Page 6 | DADOSPDF
Find OHSU Grants - Oregon Health & Science University
OPUS Würzburg | Search
... to p53 mediated G1 arrest after failed cytokinesis were analyzed by using a chemical inhibitor of the mitotic kinase Aurora B. ... Although p38 was required for the G1 cell cycle arrest after mitotic failures, long-term co-inhibition of p38 and Aurora B ... It could be shown that MAP3K4 activates the downstream stress kinase p38b to induce the p53 mediated cell cycle arrest of ... Partial inhibition of Aurora B demonstrated that chromosome missegregation also activates the MAP3K4-p38-p53 pathway, ...
Pesquisa | Portal Regional da BVS
Aurora B kinase plays essential roles in mitosis. Its protein levels increase before the onset of mitosis and sharply decrease ... Aurora B also executes important functions in interphase. Abnormal modulation of Aurora B in interphase leads to cell cycle ... In order for USP13 to exert its stabilizing effect on Aurora B, their association is promoted by the Aurora B-mediated ... Non-V600 mutations can either increase or impair BRAF kinase activity. However, impaired BRAF kinases can still activate the ...
- Like a complementary method PI3K Inhibitors to monitoring inhibition of Aurora A and B kinase exercise by Western blot, we explored the identification of transcriptional biomarkers modulated by Danusertib therapy in TP wt or mutant cell lines. (her2signaling.com)
- Finally, the kinase domains of PIKKs have been the target of numerous efforts in the development of specific inhibitors. (elifesciences.org)
- Nevertheless, the high conservation of the PIKK kinase domain has complicated efforts to develop inhibitors specifically targeting only a selected member of this family of enzymes. (elifesciences.org)
- Tyrosine kinase inhibitors (TKI) targeting the epidermal growth factor receptor (EGFR) have significantly prolonged survival in EGFR-mutant non-small cell lung cancer patients. (bvsalud.org)
- Moreover, this compound 15b showed good selectivity for cancer cells over healthy lung epithelial cells and provides additive effects with food and drug administration (FDA) approved EGFR-tyrosine kinase inhibitors (TKIs), as proven by the co-administration of 15b with Afatinib. (bvsalud.org)
- Non-small cell lung cancer (NSCLC) patients harboring activating mutations in epidermal growth factor receptor (EGFR) are sensitive to therapy with EGFR tyrosine kinase inhibitors (TKI). (bvsalud.org)
- In vitro and in vivo remedy of different pan JAK inhibitor tumor cell lines with Danusertib resulted in sizeable antiproliferative action coupled to modulation of Aurora biomarkers, which include inhibition of histone H phosphorylation, the Aurora B substrate, and of Aurora A autophosphorylation. (her2signaling.com)
- 2008) Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic cell cycle progression during Arabidopsis gametogenesis. (prolekare.cz)
- 2012) Genetic framework of cyclin-dependent kinase function in Arabidopsis. (prolekare.cz)
- 7. Takatsuka H, Umeda-Hara C, Umeda M (2015) Cyclin-dependent kinase-activating kinases CDKD;1 and CDKD;3 are essential for preserving mitotic activity in Arabidopsis thaliana. (prolekare.cz)
- A double-blind, randomized, placebo-controlled trial of adjunctive ganaxolone treatment in children and young adults with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) followed by long-term open-label treatment. (cookchildrens.org)
- Using the fission yeast Schizosaccharomyces pombe as a model system, his studies have led to the co-discovery of cyclin-dependent kinase as the key regulator molecule controlling S phase and mitosis-findings that have had implications for understanding reproduction, development, and cancer. (rockefeller.edu)
- Our lab studies the importance of Structural Maintenance of Chromosomes (SMC) complexes and cell cycle kinases, particularly Polo-like (PLK) kinases and Aurora kinases. (hopkinsmedicine.org)
- These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. (discoverx.com)
- Aurora kinase C helps the two dividing cells separate from each other and ensures that these cells each contain a complete set of chromosomes. (medlineplus.gov)
- The AURKC gene provides instructions for making a protein called aurora kinase C. This protein regulates certain events during cell division. (medlineplus.gov)
- This study uses CryoEM and biochemical studies to uncover a new and potentially important conformational off-state of a key regulatory multi-subunit protein kinase, SMG1. (elifesciences.org)
- all active PIKKs are Ser-Thr protein kinases. (elifesciences.org)
- These large, multidomain enzymes share an overall similar architecture: a C-terminal catalytic module (comprising the so-called FAT, kinase, and FATC domains) and an N-terminal α-solenoid (that typically serves as a protein-protein interaction module). (elifesciences.org)
- Several chemical drugs and their targets have been identified and characterized, including a chemical that inhibits fatty acid synthase and reduces nuclear membrane growth, and another that inhibits Aurora protein kinase. (rockefeller.edu)
- UBASH3B interacts with ubiquitylated Aurora B, one of the main kinases regulating chromosome segregation, and controls its subcellular localization but not protein levels. (uni-koeln.de)
- Familia de serina-treonina cinasas implicadas en la regulación de la MITOSIS. (bvsalud.org)
- Importantly, targeting Aurora B to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells. (uni-koeln.de)
- Function of aurora kinase C (AURKC) in human reproduction]. (cdc.gov)
- Here, we investigated the combined inhibition of polo-like kinase 1 (PLK1) and EGFR in TKI-sensitive EGFR-mutant NSCLC cells. (bvsalud.org)
- In addition, we found that c-Cbl, a ubiquitin ligase of EGFR, is a direct phosphorylation target of PLK1 and PLK1 impacts the stability of c-Cbl in a kinase-dependent manner. (bvsalud.org)
- Our results explain the specific inhibition of SMG1 by an ATP-competitive small molecule, provide insights into regulation of its kinase activity within the NMD pathway, and expand the understanding of PIKK regulatory mechanisms in general. (elifesciences.org)
- The PI3K-related kinase (PIKK) SMG1 monitors the progression of metazoan nonsense-mediated mRNA decay (NMD) by phosphorylating the RNA helicase UPF1. (elifesciences.org)
- UBASH3B is a limiting factor in this pathway and is sufficient to localize Aurora B to microtubules prior to anaphase. (uni-koeln.de)
- The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population. (medlineplus.gov)
- Wellard S, Schindler K and Jordan PW (2020) Aurora B and Aurora C kinases regulate synaptonemal complex disassembly in male mice and humans. (hopkinsmedicine.org)
- SMG1 is a member of the phosphatidylinositol-3-kinase-related kinase (PIKK) family, which also includes the ATM, ATR, DNA-PKc, and mTOR kinases ( Keith and Schreiber, 1995 ). (elifesciences.org)
- Intervienen en muchos aspectos de la división celular como la duplicación del centrosoma, la formación del HUSO ACROMÁTICO, el alineamiento de los cromosomas, su unión al huso, la activación regulada ("checkpoint activation") y la CITOCINESIS. (bvsalud.org)
- A lack of aurora kinase C blocks cell division in sperm cells. (medlineplus.gov)
- The latter compound has been used to demonstrate that the various functions of this kinase are triggered by different levels of activity. (rockefeller.edu)
- Identification of a new recurrent aurora kinase C mutation in both European and African men with macrozoospermia. (medlineplus.gov)
- 2020), we show that the SMG1 insertion domain can exert an autoinhibitory function by directly blocking the substrate-binding path as well as overall access to the SMG1 kinase active site. (elifesciences.org)
- Moreover, GOF p53 SCCs showed preferential amplification of Myc with a corresponding increase in its expression and deregulation of Aurora Kinase A. Fluorescent in situ hybridization confirmed amplification of Myc in primary GOF p53 SCCs and its retention in metastatic tumors. (arizona.edu)
- Aurora kinase C is most abundant in male testes, which are the male reproductive organs in which sperm are produced and stored. (medlineplus.gov)
- Loss of primary cilia in cells deficient for the tumor suppressor von Hippel Lindau (VHL) arise from elevated Aurora Kinase A (AURKA) levels. (nih.gov)
- Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. (nih.gov)
- However, the creation of second-generation, highly selective Aurora kinase inhibitors has increased the enthusiasm for targeting these proteins in leukemia. (nih.gov)
- Both Aurora-A and Aurora-B proteins physically interact with the H3 tail and efficiently phosphorylate Ser10 both in vitro and in vivo, even if Aurora-A appears to be a better H3 kinase than Aurora-B. Since Aurora-A and Aurora-B are known to be overexpressed in a variety of human cancers, our findings provide an attractive link between cell transformation, chromatin modifications and a specific kinase system. (nih.gov)
- The first generation of Aurora kinase inhibitors did not fare well in clinical trials, owing to poor efficacy and high toxicity. (nih.gov)
- At prophase and metaphase, Aurora-A is highly localized in the centrosomic region and in the spindle poles while Aurora-B is present in the centromeric region concurrent with H3 phosphorylation, to then translocate by cytokinesis to the midbody region. (nih.gov)
- During the G(2) phase, the Aurora-A kinase is coexpressed while the Aurora-B kinase colocalizes with phosphorylated histone H3. (nih.gov)
- 15. Tyrosine kinase inhibitors as a first-line treatment in patients with newly diagnosed chronic myeloid leukemia in chronic phase: A mixed- treatment comparison. (nih.gov)