A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.
Cyclohexanecarboxylic acids are organic compounds consisting of a cyclohexane ring substituted with a carboxylic acid group, typically represented by the structural formula C6H11COOH.
A genus of the family ORTHOMYXOVIRUS causing HUMAN INFLUENZA and other diseases primarily in humans. In contrast to INFLUENZAVIRUS A, no distinct antigenic subtypes of hemagglutinin (HEMAGGLUTININS) and NEURAMINIDASE are recognized.
Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.
Protein factors uniquely required during the initiation phase of protein synthesis in GENETIC TRANSLATION.

Regeneration of renal proximal tubules after mercuric chloride injury is accompanied by increased binding of aminoacyl-transfer ribonucleic acid. (1/123)

Homogenates of rat kidney cortex obtained 1,3 or 14 days after a single injection of HgCl2 were used to prepare the post-microsomal pH5 supernatant fraction. The activity of this fraction for peptide synthesis from [14C]phenylalanyl-tRNA was significantly increased at 1 and 3 days, at which time the proximal tubules are regenerating [Cuppage & Tate (1967) Am. J. Pathol. 51, 405-429]. This increased activity could not be attributed to a decreased inhibitory activity, but was due to an increased aminoacyl-tRNA binding, i.e. elongation-factor-1 activity, in the supernatant fraction.  (+info)

Disposition of cosalane, a novel anti-HIV agent, in isolated perfused rat livers. (2/123)

Cosalane is a potent inhibitor of HIV replication with a broad range of activity. In this study, the hepatic disposition of cosalane was investigated with a noncirculating isolated perfused rat liver technique. When 6 microM cosalane was infused into livers from untreated rats, the drug was highly extracted by the liver (only 2. 5% of influent cosalane concentration appeared in the effluent perfusate). Pretreatment of rats with various inducers of cytochrome P-450 before perfusion neither altered the effluent cosalane concentration nor resulted in the appearance of detectable metabolites in the effluent perfusate or liver homogenates. Hepatic uptake of cosalane was negligible when the drug was infused in the presence of BSA, and infusion of albumin after cosalane resulted in a significant displacement of the drug into the effluent perfusate. Furthermore, permeabilization of perfused livers with digitonin significantly diminished effluent cosalane concentration while enhancing cosalane uptake by the liver. Based on our data, it appears that a significant proportion of cosalane does not penetrate the hepatocyte membrane and may accumulate in the lipid bilayer of the cell membrane. This finding supports the proposed mechanism explaining the antiviral effect of cosalane which stipulates that this compound appears to imbed perpendicularly in the lipid bilayer of the cell membrane and the viral envelope. Also, cosalane does not seem to be metabolized by the liver as evidenced by the lack of detectable metabolites in the effluent perfusate, liver homogenates, and liver microsomal incubations.  (+info)

Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. Nucleotide requirement and inhibitor profile. (3/123)

The present studies compared caspase activation under cell-free conditions in vitro and in etoposide-treated HL-60 leukemia cells in situ. Immunoblotting revealed that incubation of HL-60 cytosol at 30 degrees C in the presence of cytochrome c and ATP (or dATP) resulted in activation of procaspases-3, -6, and -7 but not -2 and -8. Although similar selectivity was observed in intact cells, affinity labeling revealed that the active caspase species generated in vitro and in situ differed in charge and abundance. ATP and dATP levels in intact HL-60 cells were higher than required for caspase activation in vitro and did not change before caspase activation in situ. Replacement of ATP with the poorly hydrolyzable analogs 5'-adenylyl methylenediphosphate, 5'-adenylyl imidodiphosphate, or 5'-adenylyl-O-(3-thiotriphos-phate) slowed caspase activation in vitro, suggesting that ATP hydrolysis is required. Caspase activation in vitro was insensitive to phosphatase and kinase inhibitors (okadaic acid, staurosporine, and genistein) but was inhibited by Zn(2+), aurintricarboxylic acid, and various protease inhibitors, including 3,4-dichloroisocoumarin, N(alpha)-p-tosyl-L-phenylalanine chloromethyl ketone, N(alpha)-p-tosyl-L-lysine chloromethyl ketone, and N-(N(alpha)-benzyloxycarbonylphenylalanyl)alanine fluoromethyl ketone, each of which inhibited recombinant caspases-3, -6, -7, and -9. Experiments with anti-neoepitope antiserum confirmed that these agents inhibited caspase-9 activation. Collectively, these results suggest that caspase-9 activation requires nucleotide hydrolysis and is inhibited by agents previously thought to affect apoptosis by other means.  (+info)

Isolation of rabbit reticulocyte initiation factors by means of heparin bound to sepharose. (4/123)

Passage of cell-free extracts of rabbit reticulocytes through heparin-Sepharose affinity columns results in the loss of the ability of the effluent to initiate protein synthesis. This is shown by the loss of response to added rabbit globin mRNA or to inhibitors of initiation of protein synthesis, such as heparin and aurin tricarboxylic acid, and by recovery of initiation activity by addition of protein retained and subsequently eluted from the columns. The effluent retains, however, the ability to elongate protein chains. Only 0.8% of the applied cell extract protein binds to heparin-Sepharose columns. This bound protein, which can be recovered by increasing the salt concentration of the eluting buffer, has initiation factor activity equal to that of a crude initiation factor preparation obtained from rabbit reticulocyte ribosomes by extraction with 0.5 M KCl. The protein patterns on polyacrylamide gels of the initiation factors prepared by either method are very similar and indicate a protein mixture, which may represent a complex. These data confirm that heparin interacts specifically with initiation factos, and indicate that heparin-Sepharose chromatography will simplify procedures for the preparation of initiation factors.  (+info)

Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. (5/123)

Bcl2 phosphorylation at Ser-70 may be required for the full and potent suppression of apoptosis in IL-3-dependent myeloid cells and can result from agonist activation of mitochondrial protein kinase C (PKC). Paradoxically, expression of exogenous Bcl2 can protect parental cells from apoptosis induced by the potent PKC inhibitor, staurosporine (stauro). High concentrations of stauro of up to 1 microM only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKC-mediated Bcl2 phosphorylation in vitro. These data indicate a role for a stauro-resistant Bcl2 kinase (SRK). We show that aurintricarboxylic acid (ATA), a nonpeptide activator of cellular MEK/mitogen-activated protein kinase (MAPK) kinase, can induce Ser-70 phosphorylation of Bcl2 and support survival of cells expressing wild-type but not the phosphorylation-incompetent S70A mutant Bcl2. A role for a MEK/MAPK as a responsible SRK was implicated because the highly specific MEK/MAPK inhibitor, PD98059, also can only partially inhibit IL-3-induced Bcl2 phosphorylation, whereas the combination of PD98059 and stauro completely blocks phosphorylation and synergistically enhances apoptosis. p44MAPK/extracellular signal-regulated kinase 1 (ERK1) and p42 MAPK/ERK2 are activated by IL-3, colocalize with mitochondrial Bcl2, and can directly phosphorylate Bcl2 on Ser-70 in a stauro-resistant manner both in vitro and in vivo. These findings suggest a role for the ERK1/2 kinases as SRKs. Thus, the SRKs can serve to functionally link the IL-3-stimulated proliferative and survival signaling pathways and, in a novel capacity, may explain how Bcl2 can suppress stauro-induced apoptosis. In addition, although the mechanism of regulation of Bcl2 by phosphorylation is not yet clear, our results indicate that phosphorylation may functionally stabilize the Bcl2-Bax heterodimerization.  (+info)

Pharmacokinetics, biliary excretion, and tissue distribution of novel anti-HIV agents, cosalane and dihydrocosalane, in Sprague-Dawley rats. (6/123)

Cosalane and dihydrocosalane are potent inhibitors of HIV replication with a broad range of activity. The purpose of this study was to investigate: 1) the pharmacokinetic disposition of both cosalane and dihydrocosalane in male Sprague-Dawley rats, and 2) biliary excretion, enterohepatic circulation, and tissue distribution of cosalane after i.v. and/or oral administration. Animals were administered i.v. (10 mg/kg) cosalane or dihydrocosalane through a jugular vein to obtain plasma profiles. Dose dependence of cosalane was studied over a dose range of 1.0 to 10 mg/kg. The extent of enterohepatic recycling, biliary excretion, and tissue distribution were studied after i.v. administration. Both cosalane and dihydrocosalane exhibited a biexponential disposition with very long half-lives of 749 +/- 216 and 1016 +/- 407 min, along with very large volumes of distribution 23.1 +/- 4.4 and 24.4 +/- 2. 5 liter/kg, respectively. Both cosalane (nondetectable) and dihydrocosalane (<1%) showed very poor oral bioavailability. The biliary and renal excretions of cosalane were found to be negligible with no detectable metabolites either in urine or bile. After oral administration, more than 87% of the cosalane dose was excreted in the feces as the parent compound. Also, cosalane was sequestered significantly in liver with quantifiable levels in all tissues tested, even 48 h after the dose was administered. Therefore it was concluded that the poor oral bioavailability of cosalane may be due to its poor enterocytic transport coupled with sequestration in liver parenchymal cell membrane layers.  (+info)

Relationship between different stages of the corpus luteum and the expression of the peroxisome proliferator-activated receptor gamma protein in bovine large lutein cells. (7/123)

Lutein cells produce progestins that support pregnancy. Steroidogenesis requires coordination of the anabolic and catabolic pathways of lipid metabolism. Peroxisome proliferator-activated receptors (PPAR) are transcription factors that are central in the regulation of lipid metabolism. Hence, they may play a role in regulation of the development and regression of the corpus luteum. The present study investigated the expression of PPAR-gamma, n during different stages of the corpus luteum. Lutein cells were isolated mechanically from non-pregnant and pregnant heifers on days 5, 12 and 20 of the oestrous cycle (n = 3 for each day). PPAR-gamma in single cells was analysed by flow cytometry. PPAR-gamma 1 and PPAR-gamma 2 isoforms were distinguished by immunoblotting. The cell cycle of the lutein cells was measured by the flow cytometric quantification of DNA in single cells, using propidium iodide staining after ethanol fixation and RNAse treatment, and by the detection of the proliferating cell nuclear antigen (PCNA). The response of the cells to PPAR-gamma agonist 15-deoxy-delta 12,14 prostaglandin J2 (15dPGJ2, 200 and 490 nmol l-1) with and without changing the cell cycle by the anti-apoptogenic drug aurintricarboxylic acid (ATA, 10 mumol l-1) was used as an in vitro model to study the relationship between the cell cycle and PPAR-gamma. The concentration of PPAR-gamma per cell from non-pregnant heifers was significantly higher on day 5 (3.40 +/- 0.30 fmol) compared with that on day 12 (1.34 +/- 0.18 fmol, P < 0.05) and day 20 (0.55 +/- 0.2 fmol, P < 0.05). In pregnant heifers, the concentration of PPAR-gamma was significantly (P < 0.01) higher than in non-pregnant heifers. A decrease in the PPAR-gamma 1 isoform relative to PPAR-gamma 2 was observed in cells on day 12 of the oestrous cycle compared with day 5. The cell cycle (S phase portion in cells on days 5, 12 and 20: 16 +/- 4%, 6 +/- 4% and 4 +/- 3%, respectively) and the portion of cells with PCNA correlated with the amount of PPAR-gamma in non-pregnant heifers. ATA promoted the S phase in cells of non-pregnant heifers (day 12) and the endogenous agonist of PPAR-gamma, 15dPGJ2, inhibited the response to ATA in a dose-dependent manner, indicating that PPAR-gamma plays a role in the arrest of the cell cycle in lutein cells to maintain their differentiated state.  (+info)

VIP-derived sequences modified by N-terminal stearyl moiety induce cell death: the human keratinocyte as a model. (8/123)

Vasoactive intestinal peptide (VIP) is a recognized growth factor affecting many cell types. We have previously developed a series of lipophilic VIP analogues containing an N-terminal covalently attached stearyl moiety. The current studies identified stearyl-Nle(17)-VIP and stearyl-Nle(17)-neurotensin(6-11)VIP(7-28), acting at microM concentrations, as cytotoxic to human keratinocytes. The core C-terminal active VIP-derived peptide, stearyl-Lys-Lys-Tyr-Leu-NH(2) (St-KKYL-NH(2)), was identified as being responsible for the observed cytotoxicity. Cytotoxicity coincided with marked reduction in intracellular cyclic GMP and was abolished by co-treatment with the endonuclease inhibitor, aurine-tricarboxylic acid, suggesting apoptotic mechanisms. Stearyl-VIP derivatives thus offer lead compounds for future drug development against hyperproliferative skin conditions.  (+info)

Aurintricarboxylic acid (ATA) is a polyphenolic compound with antioxidant and anti-inflammatory properties. Its chemical formula is C14H8O8. It is known to inhibit several enzymes, including lipoxygenases, cyclooxygenases, and phospholipases, and has been studied for its potential therapeutic effects in various diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. However, more research is needed to fully understand its mechanisms of action and clinical applications.

Cyclohexanecarboxylic acids are a type of organic compound that consists of a cyclohexane ring, which is a six-carbon saturated hydrocarbon, substituted with a carboxylic acid group (-COOH). This group contains a carbon atom double bonded to an oxygen atom and single bonded to a hydroxyl group (-OH).

The cyclohexane ring can be in various forms, including the chair, boat, or twist-boat conformations, depending on the orientation of its constituent atoms. The carboxylic acid group can ionize to form a carboxylate anion, which is negatively charged and has a deprotonated hydroxyl group.

Cyclohexanecarboxylic acids have various applications in industry and research, including as intermediates in the synthesis of other chemicals, solvents, and pharmaceuticals. They can also be found naturally in some plants and microorganisms.

Influenza Virus B is one of the two primary types of influenza viruses that cause seasonal flu in humans, with Influenza A being the other.

Influenza Virus B primarily infects humans and is generally associated with less severe illness compared to Influenza A. However, it can still cause significant respiratory disease, hospitalizations, and deaths, particularly among high-risk populations such as young children, older adults, pregnant women, and people with certain underlying medical conditions.

Influenza Virus B has only one known host - humans, while Influenza A can infect a variety of animals, including birds, pigs, and horses, making it more prone to mutations and the emergence of new strains.

Like Influenza A, Influenza Virus B also undergoes genetic changes over time, leading to the need for regular updates to the seasonal flu vaccine to ensure that it provides protection against the circulating strains.

Reticulocytes are immature red blood cells that still contain remnants of organelles, such as ribosomes and mitochondria, which are typically found in developing cells. These organelles are involved in the process of protein synthesis and energy production, respectively. Reticulocytes are released from the bone marrow into the bloodstream, where they continue to mature into fully developed red blood cells called erythrocytes.

Reticulocytes can be identified under a microscope by their staining characteristics, which reveal a network of fine filaments or granules known as the reticular apparatus. This apparatus is composed of residual ribosomal RNA and other proteins that have not yet been completely eliminated during the maturation process.

The percentage of reticulocytes in the blood can be used as a measure of bone marrow function and erythropoiesis, or red blood cell production. An increased reticulocyte count may indicate an appropriate response to blood loss, hemolysis, or other conditions that cause anemia, while a decreased count may suggest impaired bone marrow function or a deficiency in erythropoietin, the hormone responsible for stimulating red blood cell production.

Peptide initiation factors are a group of proteins involved in the process of protein synthesis in cells, specifically during the initial stage of elongation called initiation. In this phase, they assist in the assembly of the ribosome, an organelle composed of ribosomal RNA and proteins, at the start codon of a messenger RNA (mRNA) molecule. This marks the beginning of the translation process where the genetic information encoded in the mRNA is translated into a specific protein sequence.

There are three main peptide initiation factors in eukaryotic cells:

1. eIF-2 (eukaryotic Initiation Factor 2): This factor plays a crucial role in binding methionyl-tRNAi, the initiator tRNA, to the small ribosomal subunit. It does so by forming a complex with GTP and the methionyl-tRNAi, which then binds to the 40S ribosomal subunit. Once bound, eIF-2-GTP-Met-tRNAi recognizes the start codon (AUG) on the mRNA.

2. eIF-3: This is a large multiprotein complex that interacts with both the small and large ribosomal subunits and helps stabilize their interaction during initiation. It also plays a role in recruiting other initiation factors to the preinitiation complex.

3. eIF-4F: This factor is a heterotrimeric protein complex consisting of eIF-4A (an ATP-dependent RNA helicase), eIF-4E (which binds the m7G cap structure at the 5' end of most eukaryotic mRNAs), and eIF-4G (a scaffolding protein that bridges interactions between eIF-4A, eIF-4E, and other initiation factors). eIF-4F helps unwind secondary structures in the 5' untranslated region (5' UTR) of mRNAs, promoting efficient recruitment of the 43S preinitiation complex to the mRNA.

Together, these peptide initiation factors facilitate the recognition of the correct start codon and ensure efficient translation initiation in eukaryotic cells.

"Aurintricarboxylic acid". Sigma-Aldrich. "Aurintricarboxylic Acid". Reference.MD. Skidmore AF, Beebee TJ (October 1989). " ... Aurintricarboxylic acid can be prepared by the condensation of formaldehyde with salicylic acid in the presence of nitrite- ... Aurintricarboxylic acid (ATA) is a chemical compound that readily polymerizes in aqueous solution, forming a stable free ... Salicylic acids, Phenol dyes, Tricarboxylic acids, Enoic acids, Bis(4-hydroxyphenyl)methanes). ...
Low molecular weight components of the aurintricarboxylic acid complex have been shown to be non-toxic and orally effective. ... In August 2012, McGeer and his wife Edith founded Aurin Biotech Inc., following indications that the Aurintricarboxylic acid ( ...
... , the triammonium salt of aurintricarboxylic acid, is a dye often used to detect the presence of the aluminium ion in ... Aluminon is prepared by reacting sodium nitrite with salicylic acid, adding formaldehyde, then treating with ammonia. ...
... abscisic acid MeSH D02.241.223.268.070 - aurintricarboxylic acid MeSH D02.241.223.268.220 - chlorogenic acid MeSH D02.241. ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ... hexuronic acids MeSH D02.241.081.844.915.400.500 - iduronic acid MeSH D02.241.081.901.177 - aconitic acid MeSH D02.241.081.901. ...
"Aurintricarboxylic acid". Sigma-Aldrich. "Aurintricarboxylic Acid". Reference.MD. Skidmore AF, Beebee TJ (October 1989). " ... Aurintricarboxylic acid can be prepared by the condensation of formaldehyde with salicylic acid in the presence of nitrite- ... Aurintricarboxylic acid (ATA) is a chemical compound that readily polymerizes in aqueous solution, forming a stable free ... Salicylic acids, Phenol dyes, Tricarboxylic acids, Enoic acids, Bis(4-hydroxyphenyl)methanes). ...
In a study looking at Bluetongue Virus and African horse sickness virus, polyanionic aromatic compound aurintricarboxylic acid ... Inhibition of Orbivirus Replication by Aurintricarboxylic Acid. Int J Mol Sci. 2020 Oct 2. 21 (19):7294. [QxMD MEDLINE Link]. [ ...
For instance, aurintricarboxylic acid, an anionic polymer that has been proven to bind to viral proteins, including RdRp of ... recent epidemiologic studies have indicated that the nucleic acid test in stool samples for SARS-CoV-2 could return positive ( ...
Aurintricarboxylic Acid, Trisodium Salt 13186-45-3. 2-Piperidineethanol, 95% 1484-84-0. ... Oxidizing agents, strong acids.. Hazardous Decomposition Products:. Hydrogen chloride, nitrogen oxides, carbon monoxide, ... 4-Methyl-2-Oxopentanoic Acid, Sodium Salt, Hydrate, 98+% 332360-07-3. ...
Aurintricarboxylic acid inhibits influenza virus neuraminidase. Antiviral Research, 81(2): 123-31, 2009. ... Inhibition of enterovirus 71 replication and viral 3D polymerase by aurintricarboxylic acid. Journal of Antimicrobial ... Nucleic Acids Research, 37: 47-59, 2009.. 74. Hung HC, Tseng CP, Yang JM, Ju YW, Tseng SN, Chen YF, Chao YS, Hsieh HP, Shih SR ... Nucleic Acids Research, 39(2), 9633-9648, 2011.. 104. Chen GW, Tsao KC, Huang CG, Gong YN, Chang SC, Liu YC, Wu HH, Yang SL, ...
Hung HC, Tseng CP, Yang JM, Ju YW, Tseng SN, Chen YF, Chao YS, Hsieh HP, Shih SR, Hsu JT: Aurintricarboxylic acid inhibits ... Aurintricarboxylic acid inhibits influenza virus neuraminidase, Antiviral Research, 81(2):123-31. ... Nucleic Acids Research 2009, 37:W369-W375. * Chen YC, Lo YS, Hsu WC, Yang JM: 3D-partner: a web server to infer interacting ... Chang, K. M., Chen, S. H., Kuo, C. J., Chang, C. K., Guo, R. T., Yang, J. M., and Liang, P. H. (2012) Roles of amino acids in ...
Isolation of intact plant mitochondrial RNA using aurintricarboxylic acid. 1984.. Stern, David, Newton, K. J. ...
Inhibiting miRNA processing using Aurin-tricarboxylic acid (ATA), a small molecule inhibitor of the pri-miRNA processing enzyme ... Inhibiting miRNA processing using Aurin-tricarboxylic acid (ATA), a small molecule inhibitor of the pri-miRNA processing enzyme ... Molecular Therapy Nucleic Acids, 2019. 18: p. 413-431. doi: https://doi.org/10.1016/j.omtn.2019.09.007 (2019). ...
Russ . , 1939 , 12 , 1560- 1567 ) .- The transition point of aurintricarboxylic acid ( I ) is at p 13.1 . The absorption ... absorption absorption spectra Acad acid activation energy activity adsorbed alkali alloys Amer Anal analysis approx ation atoms ...
Specific interaction of aurintricarboxylic acid with the human immunodeficiency virusCD4 cell receptor. ... tracer studies demonstrating the synthesis de novo of various essential amino acids by aphids bearing Buchnera (Fig. ... 130 Arachidonic acid 33 Articular cartilage 22, 23, 128, 165-169, 171-173, 175, 177 Aspirin 92 Bone regeneration 64, 65, 89, 91 ...
Aurintricarboxylic acid (ATA) is a derivative of quinomethanes and a selective inhibitor of TWEAK/Fn14 pathway. In this study, ... Aurintricarboxylic acid protects isoproterenol induced left ventricular hypertrophy by modulating TWEAK signaling. ...
1 mM aurintricarboxylic acid, 10 mM dithiothreitol, 5 mM thiourea, 0.1% sodium deoxycholate, 1% tergitol NP-40, and 2% PVPP (w/ ... Glucan conversion rates of untreated biomass (A), heat-treated biomass (B), and heat-treated biomass followed by a mild acid ... Acid-soluble lignin was determined by reading absorbance at 205 nm on SmartSpec Plus spectrophotometer (Bio-Rad, Herculus, CA, ... The reaction was mixed for 30 s every 10 min for 2 h. An addition of 112 ml distilled water diluted the sulfuric acid to ...
1995) Aurintricarboxylic acid reduces platelet deposition in stenosed and endothelially injured rabbit carotid arteries more ...
Additional treatments with BAPTA-AM, n-propyl gallate, vitamin E, and with aurintricarboxylic acid partially protected against ... Additional treatments with BAPTA-AM, n-propyl gallate, vitamin E, and with aurintricarboxylic acid partially protected against ... Additional treatments with BAPTA-AM, n-propyl gallate, vitamin E, and with aurintricarboxylic acid partially protected against ... Additional treatments with BAPTA-AM, n-propyl gallate, vitamin E, and with aurintricarboxylic acid partially protected against ...
... aurintricarboxylic acid (ATA), quercetin, N-acetyl- l -cysteine (NAC), or 4-amino-2,4-pyrrolidinedicarboxylic acid (APDC; all ...
Additionally, using the developed ELISA nsP1 assay, the inhibitory effects of sinefungin, aurintricarboxylic acid (ATA) and ...
Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of ... Yi He, Adam Liwo, Harold A. Scheraga, Optimization of a Nucleic Acids united-RESidue 2-Point model (NARES-2P) with a maximum- ... Łukasz P. Haliński, Alan Puckowski, Piotr Stepnowski, Glycoalkaloid, phytosterol and fatty acid contents of raw and blanched ... 2. Substitution effect on spectral and acid-base properties in the ground and excited states, The Journal of Physical Chemistry ...
Tsi CJ, Chao Y, Chen CW, Lin WW: Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in ... Acid-induced Lung Injury: Role of Nuclear Factor-κB Anesthesiology (December 2003) ... and Nuclear Factor κB Are Involved in Hemin Inhibition of Type 2 Cationic Amino Acid Transporter Expression and l-Arginine ...
Cyclohexanecarboxylic Acids. *Abscisic Acid. *Aurintricarboxylic Acid. *Chlorogenic Acid. *Chorismic Acid. *Dicyclomine. * ... Abscisic Acid Monoammonium Salt, (R)-Isomer*Abscisic Acid Monoammonium Salt, (R)-Isomer ... "Abscisic Acid" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Abscisic Acid" by people in this website by year, and whether ...
3-tricarboxylic acid manufacturers and suppliers in China, we warmly welcome you to wholesale aminoacid compounds at low price ... aurintricarboxylic acid entre em contato conosco pelo preço. 2-hydroxypropane-1,2,3-tricarboxylic acid,9-methoxy-3-methyl-9- ... 1R,2S)-1-amino-propane-1,2,3-tricarboxylic acid. Synonyms. 2-Aminotricarballylsaeure; (1R,2S)-1-Amino-propan-1,2,3- ... 1R,2S)-1-amino-propane-1,2,3-tricarboxylic acid. Obter o preço mais recente > Preço fob contact us for price ...
these included zn(2+), aurintricarboxylic acid, polyribocytidylic acid, polyriboinosinic acid, phosphonoacetic acid, and the ... chemical agents reported to inhibit the growth of various ribonucleic acid and deoxyribonucleic acid viruses were tested ... cell growth was not impaired if the individual amino acids were replaced by 3 g/l of peptone in combination with 3 g/l lah and ... 2. whereas met and trp are forced to change due to a point mutation, other amino acids (ala, arg, gly, leu, pro and val) have a ...
Aristolochic acid, Aurintricarboxylic Acid, Bombesin, Free Base, Bungarotoxin, B, C6 Ceramide, Compound 48/80, D-erythro- ... Arachidonic Acid, Artemisinin, Artemisinin, ATP, ATX II, Aurintricarboxylic Acid, Bafilomycin A1, Baicalein, BAPTA, Barium, Bcl ... Arachidonic Acid, ATP, Aurintricarboxylic Acid, Baicalein, BAPTA AM, Bastadin 5, Berbamine, Bohemine, Bombesin Free Base, ... long chain carboxylic acids, carboxylic acids, acetate, bile acids, galanin, motilin, ghrelin, thyroid-stimulating hormone, ...
Isolation of intact plant mitochondrial RNA using aurintricarboxylic acid. by Mike Rezl , Feb 18, 2018 , Uncategorized ...
Aurintricarboxylic Acid/analogs & derivatives*; Aurintricarboxylic Acid/chemistry; Cell Line, Tumor; Cell Survival; Drug ...
Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid. J. Antimicrob. Chemother. 65, ... In this light, some studies reported on a toxic effect of BR, in the presence of transition metals, on nucleic acids (Asad et ... suggests that BR acts directly on the virion particles or on nucleic acids. ...
Aurintricarboxylic acid, for example, has good efficacy and has demonstrated antiviral activity at the both the genetic and ... Several drugs, such as aurintricarboxylic acid, mitoxantrone, tetrapyroles and distamycin, have demonstrated antiviral activity ...
Aurintricarboxylic acid inhibits influenza virus neuraminidase. Hung HC, Tseng CP, Yang JM, Ju YW, Tseng SN, Chen YF, Chao YS, ...
Aurintricarboxylic acid mitigates cigarette smoke extract induced oxidative stress and pulmonary inflammation. Devi K; Singh Y ... Ursolic Acid Protected Lung of Rats From Damage Induced by Cigarette Smoke Extract.. Lin L; Hou G; Han D; Kang J; Wang Q. Front ... 1. Ursolic acid attenuates cigarette smoke-induced emphysema in rats by regulating PERK and Nrf2 pathways.. Lin L; Yin Y; Hou G ... 3. Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats.. Lin L; ...
In a study looking at Bluetongue Virus and African horse sickness virus, polyanionic aromatic compound aurintricarboxylic acid ... Inhibition of Orbivirus Replication by Aurintricarboxylic Acid. Int J Mol Sci. 2020 Oct 2. 21 (19):7294. [QxMD MEDLINE Link]. [ ...
... and aurintricarboxylic acid (ATA) [66]) or alteration of 2′O-MTase activity by interfering with the binding of NSP16 to NSP10 ( ... Mycophenolic acid may inhibit viral nucleic acid synthesis [77], but it is advisable to combine it with an interferon since its ... salvianolic acid B, etc., have potential inhibitory effects on SARS-COV-2 Mpro, while gingerol, ginnol, ferulic acid, etc., ... Caffeic acid, which is related to the ethanol extract of Sambucus FormosanaNakai [156], has been confirmed to have a ...
Aurintricarboxylic Acid, Calcium (2:3) Salt Aurintricarboxylic Acid, Triammonium Salt Aurintricarboxylic Acid, Trisodium Salt ... Cyclohexanecarboxylic Acids [D02.241.223.268] * Abscisic Acid [D02.241.223.268.034] * Aurintricarboxylic Acid [D02.241.223.268. ... Aurin Tricarboxylic Acid Aurintricarboxylate Aurintricarboxylic Acid, Calcium (1:3) Salt ... Aurintricarboxylic Acid, Trisodium Salt Narrower Concept UI. M0330822. Registry Number. 13186-45-3. Terms. Aurintricarboxylic ...
Aurintricarboxylic Acid, Calcium (2:3) Salt Aurintricarboxylic Acid, Triammonium Salt Aurintricarboxylic Acid, Trisodium Salt ... Cyclohexanecarboxylic Acids [D02.241.223.268] * Abscisic Acid [D02.241.223.268.034] * Aurintricarboxylic Acid [D02.241.223.268. ... Aurin Tricarboxylic Acid Aurintricarboxylate Aurintricarboxylic Acid, Calcium (1:3) Salt ... Aurintricarboxylic Acid, Trisodium Salt Narrower Concept UI. M0330822. Registry Number. 13186-45-3. Terms. Aurintricarboxylic ...
Potent Inhibition of Zika Virus Replication by Aurintricarboxylic Acid. Anthony Muiko May 1, 2019 ...
List of Amino Acid Abbreviations and Acronyms in Scientific & Educational Category ... Aldehyde-thionine-periodic Acid Schiff. ATA. Aurintricarboxylic Acid. ATPA. 2-amino-3-Propanoic Acid. ... Deoxyribonucleic Acid-binding Peptide. DBP-PEG/DNA. Deoxyribonucleic Acid-binding Peptide-polyethylene Glycol/deoxyribonucleic ... Home / Scientific & Educational / Amino Acid Scientific & Educational >> Amino Acid Abbreviations. Look through 890 acronyms ...
Acid, Aurin Tricarboxylic Acid, Aurintricarboxylic Aurin Tricarboxylic Acid Aurintricarboxylic Acid, Trisodium Salt - Narrower ... Aurintricarboxylic Acid, Calcium (1:3) Salt. Aurintricarboxylic Acid, Calcium (2:3) Salt. Aurintricarboxylic Acid, Triammonium ... Acid, Aurin Tricarboxylic. Acid, Aurintricarboxylic. Aluminon. Ammonium Aurintricarboxylate. Aurin Tricarboxylic Acid. ... Aurintricarboxylic Acid, Calcium (1:3) Salt - Narrower Concept UI. M0330825. Preferred term. Aurintricarboxylic Acid, Calcium ( ...
Acs Aurintricarboxylic Acid Ammonium Salt B614. RNCC: 3 , RNVC: 2 , DAC: 6. ... Silicic Acid 13 Items Hydrochloric Acid,Technical 11 Items Sulfuric Acid,Electrolyte 15 Items What is a Cupric Sulfate Solution ...
7. Aurintricarboxylic acid inhibits influenza virus neuraminidase. Hung HC, Tseng CP, Yang JM, Ju YW, Tseng SN, Chen YF, Chao ...
CCN is inhibited by aurintricarboxylic acid, a nuclease inhibitor. The point of CCN cleavage on the DNA molecule is between the ...
We identified aurintricarboxylic acid (ATA) as a nanomolar-potency antagonist of P2X3 receptor-mediated responses. Two- ... Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X3 receptors. ... Bile acids are potent inhibitors of rat P2X2 receptors. Schmidt, Axel; Joussen, Sylvia; Hausmann, Ralf; Gründer, Stefan; ... Flufenamic acid (FFA) inhibited hP2X3R, rP2X3R, and hP2X7R (IC50 values of 221 µM, 264.1 µM, and â ¼900 µM, respectively), ...
Structural analysis of inhibition mechanisms of Aurintricarboxylic Acid on SARS-CoV polymerase and other proteins. YeeLeng Yap, ... We recently published experimental results that indicated Aurintricarboxylic Acid (ATA) could selectively inhibit SARS-CoV ...
AnimalsAntiviral AgentsAurintricarboxylic AcidChlorocebus aethiopsDrug Evaluation, PreclinicalEnzyme AssaysExoribonucleases ... We have screened a library of over 5000 commercial compounds and identified patulin and aurintricarboxylic acid (ATA) as ...
Hung HC, Tseng CP, Yang JM, Ju YW, Tseng SN, Chen YF, Chao YS, Hsieh HP, Shih SR, Hsu JT: Aurintricarboxylic acid inhibits ... Hung HC, Tseng CP, Yang JM, Ju YW, Tseng SN, Chen YF, Chao YS, Hsieh HP, Shih SR, Hsu JT: Aurintricarboxylic acid inhibits ... Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the ... and nonessential amino acid mixture [0.1 mM]) containing 2.5 μg/mL trypsin and 0.3% agarose. After incubation for 2-3 days at ...
AICD and its associated DNA fragmentation are completely inhibited by aurintricarboxylic acid, a known nuclease inhibitor. The ...
... other techniques demonstrated galectin9 has apparent Aurintricarboxylic acid Inhibitor diametrical opposite roles in immune ...
Acid N0000166663 Flufenamic Acid N0000166665 Abscisic Acid N0000166667 Aurintricarboxylic Acid N0000166668 Chorismic Acid ... acid N0000006508 Aspartic Acid N0000006517 Acetic Acid N0000006518 Citric Acid N0000006520 Lactic Acid N0000006661 Sorbic Acid ... 4-isoxazolepropionic Acid N0000167151 Kainic Acid N0000167159 Oxonic Acid N0000167233 Quinolinic Acid N0000167297 Lysergic Acid ... Teichoic Acids N0000182057 Lewis Acids N0000182116 Fibric Acids N0000006801 Bile Acids and Salts N0000011372 Amino Acids, ...
... and aurintricarboxylic acid (ATA), Biochemical Pharmacology, 10.1016/0006-2952(95)02435-2, 51:8, (1015-1020), Online ... Nakajoh M, Fukushima T, Suzuki T, Yamaya M, Nakayama K, Sekizawa K and Sasaki H (2003) Retinoic Acid Inhibits Elastase-Induced ... Parihar M, Dubey A, Javeri T and Prakash P (1996) Changes in lipid peroxidation, superoxide dismutase activity, ascorbic acid ... Roig-Pérez S, Cortadellas N, Moretó M and Ferrer R (2010) Intracellular Mechanisms Involved in Docosahexaenoic Acid-Induced ...
Aurintricarboxylic acid inhibits influenza virus neuraminidase. Hung, Hui-Chen; Tseng, Ching-Ping; Yang, Jinn-Moon; Ju, Yi-Wei ...
AURINTRICARBOXYLIC ACID RUNX1 Interaction Score: 0.06 Interaction Types & Directionality: n/a. Interaction Info: ...
Achromycin V Acid, Aurin Tricarboxylic,Acid, Aurin Tricarboxylic Acidin Pepsin,Acidin Pepsin Acids, Branched-Chain Amino,Acids ... Auriculin B Aurin Tricarboxylic Acid,Aurin Tricarboxylic Acid Autologous Fibrin Tissue Adhesive,Autologous Fibrin Tissue ... Branched chain amino acid Branched-Chain Amino Acids,Branched-Chain Amino Acids Branched-chain amino acid, NOS,Branched-chain ... Serum globulin level,Serum globulin level Short chain fatty acid, NOS,Short chain fatty acid, Short-Chain Fatty Acids,Short- ...
... also known as 6-HI or 6-hydroxyindol-3-yl-acetic acid, is an organic compound with the formula C8H7NO. It is an intermediate in ... 6-Hydroxyindole, also known as 6-HI or 6-hydroxyindol-3-yl-acetic acid, is an organic compound with the formula C8H7NO. It is ... It is used in the biosynthesis of several natural products, such as melatonin, serotonin, tryptophan, and kynurenic acid. ...
Aurintricarboxylic T003889Aurintricarboxylic Acid T003890Acid, Aurin Tricarboxylic T003890Aurin Tricarboxylic Acid ... Amino Acid T001797Amino Acid Sequences T001798Sequence, Amino Acid T001799Sequences, Amino Acid T001800Amino Acid Sequence ... Amino Acid T001786Activations, Amino Acid T001786Amino Acid Activation T001786Amino Acid Activations T001787Amino Acid ... D-Amino Acid T010491D Amino Acid Oxidase T010491D-Amino-Acid Oxidase T010491Oxidase, D-Amino-Acid T010492Acid Oxidase, dextro- ...
  • Aurintricarboxylic acid (ATA) is a chemical compound that readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. (wikipedia.org)
  • It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. (wikipedia.org)
  • Inhibiting miRNA processing using Aurin-tricarboxylic acid (ATA), a small molecule inhibitor of the pri-miRNA processing enzyme Drosha completely rescues TGF-β -mediated CFTR suppression suggesting an important role for miRNA mediated post-transcriptional gene silencing. (fiu.edu)
  • Aurintricarboxylic acid (ATA) is a derivative of quinomethanes and a selective inhibitor of TWEAK/Fn14 pathway. (bvsalud.org)
  • citation needed] Aurintricarboxylic acid and its ammonium salt shows antiviral activity in vitro against coronaviruses such as SARS, MERS and SARS-CoV-2, and while it is unlikely to have suitable properties to be developed as a medicine in its own right, it has proved useful in scientific research into novel antiviral drugs to combat these diseases. (wikipedia.org)
  • This graph shows the total number of publications written about "Abscisic Acid" by people in this website by year, and whether "Abscisic Acid" was a major or minor topic of these publications. (ouhsc.edu)
  • It has been discovered that using aurintricarboxylic acid against influenza-A post-infection has a strong protective effect by inhibiting the virus' ability to reproduce. (wikipedia.org)
  • Aurintricarboxylic acid (ATA) is a chemical compound that readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. (wikipedia.org)
  • Aurintricarboxylic acid can be prepared by the condensation of formaldehyde with salicylic acid in the presence of nitrite-containing sulfuric acid. (wikipedia.org)
  • citation needed] Aurintricarboxylic acid and its ammonium salt shows antiviral activity in vitro against coronaviruses such as SARS, MERS and SARS-CoV-2, and while it is unlikely to have suitable properties to be developed as a medicine in its own right, it has proved useful in scientific research into novel antiviral drugs to combat these diseases. (wikipedia.org)
  • We have screened a library of over 5000 commercial compounds and identified patulin and aurintricarboxylic acid (ATA) as inhibitors of nsp14 exoribonuclease in vitro. (figshare.com)