An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.
A thioglucose derivative used as an antirheumatic and experimentally to produce obesity in animals.
A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.
A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
Unstable isotopes of selenium that decay or disintegrate emitting radiation. Se atoms with atomic weights 70-73, 75, 79, 81, and 83-85 are radioactive selenium isotopes.
Inorganic compounds that contain gold as an integral part of the molecule.
The deliberate and methodical practice of finding new applications for existing drugs.
A FLAVOPROTEIN enzyme that catalyzes the oxidation of THIOREDOXINS to thioredoxin disulfide in the presence of NADP+. It was formerly listed as EC 1.6.4.5
The cause of TETANUS in humans and domestic animals. It is a common inhabitant of human and horse intestines as well as soil. Two components make up its potent exotoxin activity, a neurotoxin and a hemolytic toxin.

Does sulphasalazine cause drug induced systemic lupus erythematosus? No effect evident in a prospective randomised trial of 200 rheumatoid patients treated with sulphasalazine or auranofin over five years. (1/105)

BACKGROUND: Sulphasalazine (SSZ) has been reported to cause drug induced systemic lupus erythematosus (SLE), but diagnosis of this complication in the context of rheumatoid arthritis (RA) is difficult. OBJECTIVE: To determine prospectively: (1) if patients become seropositive for antinuclear antibodies (ANA) during prolonged treatment with SSZ without clinical evidence of SLE; (2) if ANA positive patients develop more adverse reactions than ANA negative patients; (3) if drug induced SLE was identified in this cohort. METHODS: 200 patients enrolled in a randomised prospective trial of SSZ and auranofin (AUR) were followed up for five years. Baseline and annual ANA results were collected along with information on drug toxicity and reasons for discontinuation of treatment. RESULTS: Over five years 24 patients stopped taking SSZ and 49 AUR because of side effects. Of the features common to SLE, rash developed in nine SSZ patients and 11 AUR treated patients and mouth ulcers in three and four patients respectively. Six SSZ treated patients and three treated with AUR developed leucopenia, which promptly resolved with drug withdrawal. No adverse event was ascribed to drug induced SLE. Of the 72 SSZ treated patients who were ANA negative or weakly positive at outset, 14 (19%) became strongly ANA positive compared with 11 (14%) of 80 AUR patients. Patients ANA positive at baseline or who became ANA positive were not more likely to develop drug toxicity or to withdraw from treatment than those ANA negative throughout. CONCLUSION: ANA positivity is common in patients with RA, but the presence or development of ANA did not increase the likelihood of withdrawing from treatment. No case of drug induced SLE was seen over five years in this study.  (+info)

Effects of anti-rheumatic gold salts on NF-kappa B mobilization and tumour necrosis factor-alpha (TNF-alpha)-induced neutrophil-dependent cytotoxicity for human endothelial cells. (2/105)

We have previously shown that the gold-containing disease-modifying anti-rheumatic drugs, auranofin (AF) and gold sodium aurothiomalate (GSTM) reduce human umbilical vein endothelial cell (HUVEC) adhesion molecule expression and neutrophil (PMN) adherence. AF diminishes E-selectin and intercellular adhesion molecule-1 (ICAM-1) on cytokine-activated HUVEC, while GSTM decreases only E-selectin. Since tight adhesion is critical for PMN to damage EC, we tested whether these drugs modulated human PMN-mediated injury to TNF-alpha-activated HUVEC in vitro (as measured by 51Cr release). Here we show that TNF-alpha caused a prominent PMN-mediated cytotoxicity that was dose-dependently reduced when AF and GSTM were added to the assay system. We also found that a potent inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC) in a dose-dependent manner impaired TNF-alpha-induced cytotoxicity, indicating a role of NF-kappaB activation in cytokine-induced endothelial injury. To examine the effects of AF and GSTM on TNF-alpha-induced NF-kappaB activation this was measured in HUVEC nuclear extracts by an electrophoretic mobility shift assay. AF, but not GSTM, decreased TNF-alpha-induced NF-kappaB activation in HUVEC. Thus, in this in vitro model of vasculitis, AF and GSTM dose dependently reduced TNF-alpha-mediated neutrophil-dependent cytotoxicity for HUVEC, and AF, but not GSTM, inhibited NF-kappaB mobilization, thereby providing possible mechanisms for effects of AF and GSTM.  (+info)

Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase. (3/105)

Gold compounds are used in the treatment of rheumatoid arthritis. NF-kappa B is a transcription factor implicated in the expression of many inflammatory genes. NF-kappa B is activated by signal-induced phosphorylation and subsequent degradation of inhibitory I kappa B (inhibitory protein that dissociates from NF-kappa B) proteins, and a multisubunit I kappa B kinase (IKK) has been identified previously. We tested the effect of various gold compounds on the activation of NF-kappa B and IKK in LPS-stimulated RAW 264.7 mouse macrophages. A lipophilic gold compound, auranofin, suppressed the LPS-induced increase of nuclear kappa B-binding activity, degradation of I kappa B proteins, and IKK activation. Auranofin also blocked IKK activation induced by TNF and PMA/ionomycin, suggesting that the target of auranofin action is common among these diverse signal pathways. In vitro IKK activity was suppressed by addition of hydrophilic gold compounds, such as aurothiomalate, aurothioglucose, and AuCl3. Other thiol-reactive metal ions such as zinc and copper also inhibited IKK activity in vitro, and induction of IKK in LPS-stimulated macrophages. In vitro IKK activity required the presence of reducing agent and was blocked by addition of thiol group-reactive agents. Two catalytic subunits of IKK complex, IKK alpha and IKK beta, were both inhibited by these thiol-modifying agents, suggesting the presence of a cysteine sulfhydryl group in these subunits, which is critical for enzyme activity. The antiinflammatory activity of gold compounds in the treatment of rheumatoid arthritis may depend on modification of this thiol group by gold.  (+info)

Aggressive treatment in early rheumatoid arthritis: a randomised controlled trial. On behalf of the Rheumatic Research Foundation Utrecht, The Netherlands. (4/105)

OBJECTIVES: To compare three therapeutic strategies using slow acting antirheumatic drugs (SAARDs) in early rheumatoid arthritis (RA), for their disease modifying properties, toxicity, and lag time until treatment effect. METHODS: Patients with recent onset RA from six hospitals were randomly assigned to immediate initiation of one of three treatment strategies: (I) a "mild SAARD with a long lag time" (hydroxychloroquine, if necessary replaced by auranofin); (II) a "potent SAARD with a long lag time" (intramuscular gold, if necessary replaced by D-penicillamine); (III) a "potent SAARD with a short lag time" (methotrexate, if necessary replaced by sulfasalazine). Comparisons included two years of follow up. RESULTS: All SAARD strategies reduced mean disease activity. A greater percentage of patients improved clinically with strategies II and III than with strategy I: percentages of patients improved on joint score with strategies II and III (79% and 82%, respectively), which was statistically different from strategy I (66%). The same was true for remission percentages: 31% and 24% v 16%, respectively). Longitudinal analysis showed significantly less disability with strategy III, and a lower erythrocyte sedimentation rate with strategy II than with strategy I. In addition, radiological damage after one and two years, was significantly lower in strategies II and III (at two years median scores were 11 and 10 v 14 in strategy I, p<0.05). Toxicity was increased in strategy II compared with the other strategies. CONCLUSION: Strategy III, comprising methotrexate or sulfasalazine, produced the best results weighing effectiveness and toxicity. Strategy I (hydroxychloroquine or auranofin) was slightly less effective, and strategy II (intramuscular gold or D-penicillamine) was associated with increased toxicity.  (+info)

Inhibition of interleukin-12 production by auranofin, an anti-rheumatic gold compound, deviates CD4(+) T cells from the Th1 to the Th2 pathway. (5/105)

1. Interleukin-12 (IL-12) may play a central role in the development and progression of rheumatoid arthritis by driving the immune response towards T helper 1 (Th1) type responses characterized by high IFN-gamma and low IL-4 production. In this study we investigated the effect of auranofin (AF), an anti-rheumatic gold compound, on IL-12 production in mouse macrophages and dendritic cells, and studied whether AF-mediated inhibition of IL-12 production could regulate a cytokine profile of antigen (Ag)-primed CD4(+) Th cells. 2. Treatment with AF significantly inhibited IL-12 production in lipopolysaccharide (LPS)-stimulated macrophages and also in CD40L-stimulated dendritic cells. AF-pretreated macrophages reduced their ability to induce IFN-gamma and increased the ability to induce IL-4 in Ag-primed CD4(+) T cells. AF did not influence the cell surface expression of the class II MHC molecule and the costimulatory molecules CD80 and CD86. 3. Addition of recombinant IL-12 to cultures of AF-pretreated macrophages and CD4(+) T cells restored IFN-gamma production in Ag-primed CD4(+) T cells. 4. The in vivo administration of AF resulted in the inhibition of IL-12 production by macrophages stimulated in vitro with LPS or heat-killed Listeria monocytogenes (HKL), leading to the inhibition of Th1 cytokine profile (decreased IFN-gamma and increased IL-4 production) in Ag-primed CD4(+) T cells. 5. These findings may explain some known effects of AF including anti-rheumatic effects and the inhibition of encephalitogenicity, and point to a possible therapeutic use of AF in the Th1-mediated immune diseases such as autoimmune diseases.  (+info)

Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative. (6/105)

1 Gold(I)-thiolate drugs are compounds that specifically interact with thiol and/or selenol groups and are essentially utilized in the treatment of rheumatoid arthritis. 2 Considering the importance of thiol groups in regulating mitochondrial membrane permeability, the effects of auranofin (S-triethylphosphinegold(I)-2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranoside) , a second-generation gold drug, were studied on mitochondria isolated from rat liver. 3 Auranofin, at submicromolar concentrations, was able to induce the mitochondrial membrane permeability transition observed as swelling and loss of membrane potential. Both events are completely inhibited by cyclosporin A, the specific inhibitor of mitochondrial permeability transition. Calcium ions and energization by succinate are required for the occurrence of permeability transition. 4 By interacting with the active site selenol group, auranofin results as an extremely potent inhibitor of mitochondrial thioredoxin reductase, both isolated and in its mitochondrial environment. 5 It is concluded that auranofin, in the presence of calcium ions, is a highly efficient inducer of mitochondrial membrane permeability transition, potentially referable to its inhibition of mitochondrial thioredoxin reductase.  (+info)

Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit. (7/105)

Antirheumatic gold compounds have been shown to inhibit NF-kappaB activation by blocking IkappaB kinase (IKK) activity. To examine the possible inhibitory mechanism of gold compounds, we expressed wild type and mutant forms of IKKalpha and beta subunits in COS-7 cells and determined the effect of gold on the activity of these enzymes both in vivo and in vitro. Substitution of Cys-179 of IKKbeta with alanine (C179A) rendered the enzyme to become resistant to inhibition by a gold compound auranofin, however, similar protective effect was not observed with an equivalent level of IKKalpha (C178A) mutant expressed in the cells. Auranofin inhibited constitutively active IKKalpha and beta and variants; IKKalpha (S176E, S180E) or IKKbeta (S177E, S181E), suggesting that gold directly cause inhibition of activated enzyme. The different inhibitory effect of auranofin on IKKalpha (C178A) and IKKbeta (C179A) mutants indicates that gold could inhibit the two subunits of IKK in a different mode, and the inhibition of NF-kappaB and IKK activation induced by inflammatory signals in gold-treated cells appears through its interaction with Cys-179 of IKKbeta.  (+info)

Prospective trial comparing the use of sulphasalazine and auranofin as second line drugs in patients with rheumatoid arthritis. (8/105)

Two hundred patients with rheumatoid arthritis were studied in a prospective open trial comparing treatment with sulphasalazine and auranofin in patients with active disease over 12 months. The two drugs improved many parameters of disease activity at 12, 24, and 48 weeks. At 12 weeks, the group treated with sulphasalazine had a lower platelet count (Mann-Whitney U test), erythrocyte sedimentation rate, and articular index, with a greater decrease in erythrocyte sedimentation rate (Students t test) and C reactive protein between 0 and 12 weeks. There were no significant differences between sulphasalazine and auranofin treatment after 24 and 48 weeks. Life table analysis showed no significant differences in the rate of side effects which caused treatment to be stopped. Sulphasalazine works more rapidly, may be a more effective disease modifying antirheumatic drug, and is as well tolerated as auranofin.  (+info)

Auranofin is a medication that contains gold and is used in the treatment of rheumatoid arthritis. It belongs to a class of drugs called gold-containing compounds, which are used to reduce inflammation and joint damage caused by rheumatoid arthritis.

Auranofin works by inhibiting certain enzymes that play a role in the inflammatory response, which can help to reduce swelling, pain, and stiffness in the joints. It is taken orally, usually in the form of a tablet, and is typically prescribed for use in combination with other medications used to treat rheumatoid arthritis.

It's important to note that auranofin can have serious side effects, including kidney damage, mouth sores, and skin rashes, and it should only be used under the close supervision of a healthcare provider. Additionally, regular monitoring of blood and urine tests is necessary while taking this medication to ensure that it is not causing any harmful effects on the body.

Aurothioglucose is a gold-containing medication that has been used in the treatment of rheumatoid arthritis. It works by modulating the immune system and reducing inflammation in the joints. The medication is administered via injection, usually into a muscle (intramuscularly).

The use of aurothioglucose has declined in recent years due to the availability of newer and more effective medications for rheumatoid arthritis. Additionally, aurothioglucose can have significant side effects, including kidney damage, skin reactions, and blood disorders. It is important to be monitored by a healthcare provider while taking this medication to ensure that it is safe and effective for use.

Gold sodium thiomalate is a disease-modifying antirheumatic drug (DMARD) that contains gold, which can help reduce pain, swelling, and stiffness in joints caused by rheumatoid arthritis. It works by possibly inhibiting certain enzymes involved in inflammation and modulating the immune system's response to reduce tissue damage.

This medication is given as an intramuscular injection and requires medical supervision due to its potential side effects, including kidney and liver problems, skin rashes, mouth sores, and changes in blood cell counts. Regular monitoring of blood and urine tests is necessary during treatment with gold sodium thiomalate.

It's important to note that the use of this medication has declined over time due to the availability of newer and more effective treatments for rheumatoid arthritis, as well as its potential side effects.

I believe there may be some confusion in your question. Gold is typically a chemical element with the symbol Au and atomic number 79. It is a dense, soft, malleable, and ductile metal. It is one of the least reactive chemical elements and is solid under standard conditions.

However, if you are referring to "Gold" in the context of medical terminology, it may refer to:

1. Gold salts: These are a group of compounds that contain gold and are used in medicine for their anti-inflammatory properties. They have been used in the treatment of rheumatoid arthritis, although they have largely been replaced by newer drugs with fewer side effects.
2. Gold implants: In some cases, a small amount of gold may be surgically implanted into the eye to treat conditions such as age-related macular degeneration or diabetic retinopathy. The gold helps to hold the retina in place and can improve vision in some patients.
3. Gold thread embedment: This is an alternative therapy used in traditional Chinese medicine, where gold threads are embedded into the skin or acupuncture points for therapeutic purposes. However, there is limited scientific evidence to support its effectiveness.

I hope this information helps! If you have any further questions, please let me know.

Selenium radioisotopes are unstable forms of the element selenium that emit radiation as they decay into more stable forms. These isotopes can be produced through various nuclear reactions, such as irradiating a stable selenium target with protons or alpha particles. Some examples of selenium radioisotopes include selenium-75, selenium-79, and selenium-81.

Selenium-75 is commonly used in medical imaging to study the function of the thyroid gland, as it accumulates in this gland and can be detected using a gamma camera. Selenium-79 and selenium-81 have potential uses in cancer treatment, as they can be incorporated into compounds that selectively target and destroy cancer cells. However, more research is needed to fully understand the potential benefits and risks of using these radioisotopes in medical treatments.

It's important to note that handling and using radioisotopes requires special training and precautions, as they can be dangerous if not handled properly. Exposure to radiation from radioisotopes can increase the risk of cancer and other health problems, so it's essential to use them only under controlled conditions and with appropriate safety measures in place.

Gold compounds refer to chemical combinations in which gold atoms are bonded with other elements. In the context of medicine, particularly in the field of rheumatology, gold compounds have been used as disease-modifying antirheumatic drugs (DMARDs) for the treatment of conditions such as rheumatoid arthritis.

The most commonly used gold compound is auranofin, which contains gold in the +1 oxidation state. Auranofin is an oral medication that can help reduce inflammation and slow down joint damage caused by rheumatoid arthritis. It works by inhibiting certain enzymes involved in the inflammatory response.

Other gold compounds, such as sodium aurothiomalate and gold thioglucose, are administered parenterally (usually intramuscularly) and contain gold in the +3 oxidation state. These medications also have anti-inflammatory properties and can help alleviate symptoms of rheumatoid arthritis.

It is important to note that the use of gold compounds as a treatment for rheumatoid arthritis has declined over time due to their side effects, which may include kidney damage, skin reactions, mouth ulcers, and bone marrow suppression. They are generally reserved for patients who have not responded well to other DMARDs or biologic agents.

Drug repositioning, also known as drug repurposing or therapeutic switching, refers to the process of discovering new uses for approved or investigational drugs that are outside the scope of their original medical indication. This strategy leverages existing knowledge about a drug's safety, efficacy, and pharmacological properties to expedite development and reduce costs compared to de novo drug discovery. By finding new therapeutic applications for existing drugs, drug repositioning can provide faster and more cost-effective treatment options for various diseases, including neglected and rare disorders.

Thioredoxin-disulfide reductase (Txnrd, TrxR) is an enzyme that belongs to the pyridine nucleotide-disulfide oxidoreductase family. It plays a crucial role in maintaining the intracellular redox balance by reducing disulfide bonds in proteins and keeping them in their reduced state. This enzyme utilizes NADPH as an electron donor to reduce thioredoxin (Trx), which then transfers its electrons to various target proteins, thereby regulating their activity, protein folding, and antioxidant defense mechanisms.

Txnrd is essential for several cellular processes, including DNA synthesis, gene expression, signal transduction, and protection against oxidative stress. Dysregulation of Txnrd has been implicated in various pathological conditions, such as cancer, neurodegenerative diseases, and inflammatory disorders. Therefore, understanding the function and regulation of this enzyme is of great interest for developing novel therapeutic strategies.

'Clostridium tetani' is a gram-positive, spore-forming, anaerobic bacterium that is the causative agent of tetanus. The bacteria are commonly found in soil, dust, and manure, and can contaminate wounds, leading to the production of a potent neurotoxin called tetanospasmin. This toxin causes muscle spasms and stiffness, particularly in the jaw and neck muscles, as well as autonomic nervous system dysfunction, which can be life-threatening. Tetanus is preventable through vaccination with the tetanus toxoid vaccine.

Preliminary results show that auranofin contributed to a decrease in the viral reservoir. Auranofin has been identified in a ... were treated with auranofin, the PKCι inhibitor auranofin inhibited KP tumor growth and sensitized these tumors to α-PD-1. The ... Auranofin is a gold salt classified by the World Health Organization as an antirheumatic agent. It has the brand name Ridaura. ... Drug-screening reveals auranofin induces apoptosis in ovarian cancer cells in vitro. When mice with Protein kinase Cι (PKCι)- ...
Compounds containing metal ions can be used as medicine, such as lithium compounds and auranofin. Metal compounds and ions can ... Kean WF, Hart L, Buchanan WW (May 1997). "Auranofin". British Journal of Rheumatology. 36 (5): 560-572. doi:10.1093/ ...
Auranofin, a chelate complex of gold, is used in the treatment of rheumatoid arthritis, and penicillamine, which forms chelate ... Kean WF, Hart L, Buchanan WW (May 1997). "Auranofin". British Journal of Rheumatology. 36 (5): 560-72. doi:10.1093/rheumatology ...
Auranofin Shaw, III C. F. (1999). "Gold-Based Therapeutic Agents". Chemical Reviews. 99 (9): 2589-600. doi:10.1021/cr980431o. ... It was recently discontinued from the US market along with sodium aurothiomalate leaving only Auranofin as the only gold salt ... Only one gold drug remains in active clinical use for this purpose in the United States: auranofin although sodium ... In the United Kingdom, only sodium aurothiomalate and auranofin were used recently. In 2001, aurothioglucose was withdrawn from ...
Beck RK (2002). "Auranofin and Aurothioglucose side effects & overdose". Drug Reference for EMS Providers. pp. 164-165. " ... "Auranofin complete list of warnings, precautions and reactions". Drugs.com. "Aurothioglucose Suspension adverse effects". ... Auranofin (UK & US) Aurothioglucose (Gold thioglucose) (US) Shaw CF (September 1999). "Gold-based therapeutic agents". Chemical ...
Gold antiarthritic drugs, e.g. auranofin have been commercialized. Carbon monoxide-releasing molecules are metal complexes have ...
"Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis". Proceedings of the National ...
Emoxypine Pirisudanol Sulbutiamine Lemmel EM (May 1993). "Comparison of pyritinol and auranofin in the treatment of rheumatoid ...
Along with an orally-administered gold salt, auranofin, it is one of only two gold compounds currently employed in modern ... Iqbal MS, Saeed M, Taqi SG (2008). "Erythrocyte membrane gold levels after treatment with auranofin and sodium aurothiomalate ... It was recently discontinued from the US market along with aurothioglucose leaving only auranofin as the only gold salt on the ... auranofin and penicillamine in the treatment of patients with rheumatoid arthritis". British Journal of Rheumatology. 37 (9): ...
Auranofin Aurothioglucose Gold salts Sodium aurothiomalate Shaw III CF (September 1999). "Gold-based therapeutic agents". ...
In 2017, auranofin completed phase I clinical trials against Entamoeba histolytica and Giardia The Barrios Lab in the ... Through a high-throughput drug screen, they found that auranofin, which is commonly used for rheumatoid arthritis, targets TrxR ... "Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent". Antimicrobial Agents and Chemotherapy. 61 (1): ...
April 2015). "Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis". Proceedings of the ... such as auranofin or Ebselen.) This is especially true for Mycobacterium Haemophilum, and could be used for antibiotic ...
The compound is a common ligand in organometallic chemistry, such as in auranofin. It is a pyramidal molecule with approximate ...
Sodium aurothiomalate, auranofin, and cyclosporin are less commonly used due to more common adverse effects. However, ... and auranofin. Additionally, rituximab and tocilizumab are monoclonal antibodies and are also DMARDs. Use of tocilizumab is ...
In 2017 she demonstrated that taking Auranofin whilst on RAPTA-T enhances the activity of the anti-cancer drug. She teaches ...
... * treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, ... auranofin inhibits thioredoxin reductase, captopril inhibits angiotensin converting enzyme, celecoxib blocks cyclooxygenase-2, ...
It has also been shown to reduce both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin ... "Glutaredoxin 2 reduces both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin and 4- ...
QM01BA99 Combinations M01CA03 Oxycinchophen M01CB01 Sodium aurothiomalate M01CB02 Sodium aurothiosulfate M01CB03 Auranofin ...
... sodium aurothiomalate and auranofin). These drugs have been explored as a means to help to reduce the pain and swelling of ...
... auranofin MeSH D02.691.675.500 - gold sodium thiomalate MeSH D02.691.750.100 - alkylmercury compounds MeSH D02.691.750.100.229 ...
... auranofin, acetaminophen, nimesulide, paraquat, ethoxyquin, diesel exhaust particles, silica, nanotubes, 15-deoxy-Δ12,14 ...
Atrosept Atrovent Attenuvax Augmentin Auralgan auranofin (INN) Aureomycin Aurexis (Inhibitex) Aurodex Aurolate ...
... platinum containing anticancer agents gold salts such as auranofin - anti-inflammatory for treatment of arthritis silver ...
Auranofin, Buthionine Sulfoximine and Suppressive Antiretroviral Therapy Induce Post-Therapy Control of Viremia in Chronically ...
Auranofin) 2-(1-Aziridinyl)ethanol Aziridyl benzoquinone Azobenzene 11H-Benz[bc]aceanthrylene Benz[l]aceanthrylene Benz[a] ...
Preliminary results show that auranofin contributed to a decrease in the viral reservoir. Auranofin has been identified in a ... were treated with auranofin, the PKCι inhibitor auranofin inhibited KP tumor growth and sensitized these tumors to α-PD-1. The ... Auranofin is a gold salt classified by the World Health Organization as an antirheumatic agent. It has the brand name Ridaura. ... Drug-screening reveals auranofin induces apoptosis in ovarian cancer cells in vitro. When mice with Protein kinase Cι (PKCι)- ...
Auranofin: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking auranofin,. *tell your doctor and pharmacist if you are allergic to auranofin or any other drugs. ... If you become pregnant while taking auranofin, call your doctor. You should not try to become pregnant while taking auranofin ... Auranofin may cause an upset stomach. Take auranofin after meals or a light snack. ...
They tested two drugs called auranofin and palbociclib to stop mesothelioma from spreading in a patients body. The team is ...
ព័ត៌មានឱសថត្រូវបានរៀបរៀងដោយ អ៊ីម៉ាតុគឹ មេឌីក (ខេមបូឌា) ដោយផ្អែកលើប្រភពព័ត៌មានខាងក្រោម។ សម្រាប់ព័ត៌មានលម្អិត សូមស្វែងរកនៅក្នុងក្រដាសព័ត៌មាននៃឱសថនីមួយៗ ឬ សាកសួរទៅកាន់ក្រុមហ៊ុនឱសថឬតំណាងចែកចាយនៃឱសថនីមួយៗ។. ប្រភពព័ត៌មាន៖. - ក្រដាសព័ត៌មាននៃឱសថសម្រាប់អ្នកជំនាញវេជ្ជសាស្ត្រដែលប្រើប្រាស់នៅប្រទេសជប៉ុន (Pharmaceutical and Medical Devices Agency, Pmda): https://www.pmda.go.jp. - ...
Find information on Auranofin (Ridaura) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... "Auranofin." Daviss Drug Guide, 18th ed., F.A. Davis Company, 2023. Emergency Central, emergency.unboundmedicine.com/emergency/ ... view/Davis-Drug-Guide/51082/all/auranofin. Vallerand AHA, Sanoski CAC, Quiring CC. Auranofin. Daviss Drug Guide. F.A. Davis ... Vallerand, A. H., Sanoski, C. A., & Quiring, C. (2023). Auranofin. In Daviss Drug Guide (18th ed.). F.A. Davis Company. https ...
auranofin Submit Updates Laplantine et al., The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry ... Auranofin has been reported as potentially beneficial for treatment of COVID-19. We have not reviewed these studies. See all ...
Biocompatible Nanoparticle Technology Being Used to Develop Cancer Therapies & Rapid Diagnostics. ...
Effect of auranofin treatment on aberrant splenic interleukin production in adjuvant arthritic rats. J C Lee; J C Lee ... J C Lee, M J Dimartino, B J Votta, N Hanna; Effect of auranofin treatment on aberrant splenic interleukin production in ... In contrast, auranofin administered to normal rats, in the same dosing regimen, did not affect interleukin production. ... Therapeutic administration of auranofin to AA rats with established disease resulted in normalization of IL-1 production ...
Chemical Compound Auranofin analogue , Compound overview, Drug targets, Compound forms, Similar compounds , canSAR.ai ...
... auranofin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, ... encoded search term (auranofin (Ridaura)) and auranofin (Ridaura) What to Read Next on Medscape ...
2022-RA-980-ESGO Auranofin as a potential anticancer drug in epithelial ovarian cancer ... 2022-RA-980-ESGO Auranofin as a potential anticancer drug in epithelial ovarian cancer ...
Dive into the research topics of Review of auranofin, an oral chrysotherapeutic agent. Together they form a unique ...
Inhibition of selenoprotein synthesis is not the mechanism by which auranofin inhibits growth of Clostridioides difficile * ...
gold (Auranofin, Ridaura, Myochrysine). *chlorambucil (Leukeran). *cyclcophosphamide (Cytoxan). *Biological response modifiers ...
Gynecomastia is a benign enlargement of the male breast resulting from a proliferation of the glandular component of the breast (see the image below). Gynecomastia is defined clinically by the presence of a rubbery or firm mass extending concentrically from the nipples.
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above. ...
If you are using this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress. Your dose of this medicine might need to be changed for a short time while you have extra stress. Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor right away if you have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness. This medicine may cause you to get more infections than usual. Avoid people who are sick or have infections and wash your hands often. If you are exposed to chickenpox or measles, tell your doctor right away. If you start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away. Check with your doctor right away ...
keywords = "Auranofin, CA-125, Gold, Ovarian cancer",. author = "Aminah Jatoi and {Radecki Breitkopf}, Carmen and Foster, { ... A mixed-methods feasibility trial of protein kinase C iota inhibition with auranofin in asymptomatic ovarian cancer patients. ... Dive into the research topics of A mixed-methods feasibility trial of protein kinase C iota inhibition with auranofin in ... The median progression-free survival was 2.8 months (95% CI: 1.3-3.8); auranofin was well tolerated. One patient had baseline ...
Auranofin. Ridaura. Antiarthritic. Gold Compound. Azatadine. Optimine. Antihistamine. Back to top of Photosensitizing ...
Overall, Auranofin should prevent SARS-CoV-2 infection and inflammatory damages, offering new opportunities as a repurposable ... First, it inhibits a raft-dependent endocytic pathway involved in SARS-CoV-2 entry into host cells; Second, Auranofin alters ... Among these, we show that Auranofin prevents post-translational modifications of NF-κB effectors and their recruitment into ... The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling. ...
Bladder cancer remains a very challenging disease to treat with the high rates of recurrence and progression associated with current therapies. Although the association between bladder cancer pathology and circRNAs remains undetermined, circRNAs signatures may be useful as prognostic and predictive factors and clinical tools for assessing disease state and outcome. This study investigates if these circRNAs can be used as biomarkers for bladder cancer diagnosis. Using bioinformatics method to analysis GEO databases (GSE37815, GSE39093, GSE97239, and GSE92675) for differentially expressed RNAs in bladder cancer and normal bladder tissues were screened from. The related volcanic maps and the interaction network maps of differentially expressed RNAs were drawn, and the mRNA-miRNA and miRNA-circRNA interaction were predicted to establish mRNA-miRNA-circRNA competitive endogenous RNA (ceRNA) network. The differential circRNAs related to prognosis of bladder cancer patients were screened based on the ...
Auranofina. Aurotioglucosa. Busulfan. Capecitabina. Carbamazepina. Carboplatino. Carmustina. Ceftizoxima. Clorambucil. ...
Auranofin) More information View prices Rifadin and/or alternatives (Rifampin) More information View prices ...
Auranofina. Aurothioglucosa. Butabarbital. Carbenicilina. Dalteparina. Denileukina. Diclofenac. Dicloxacilina. Dimenhidrinato. ...
Auranofin (Ridaura) 2. Salts 3. Doxorubicin (Adriamycin) 4. Penicillamine (Cuprimine) 5. tiotropium (Spiriva) ...
auranofin. Monitor Closely (1)auranofin decreases effects of sipuleucel-T by pharmacodynamic antagonism. Modify Therapy/Monitor ... auranofin. auranofin decreases effects of sipuleucel-T by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. ...
Arthritis drug auranofin improves diabetes symptoms in mice. Baylor College of Medicine researchers discovered that the ... rheumatoid arthritis drug auranofin can potentially be repurposed to improve diabetes-associated... ...
Speciation Analysis Highlights the Interactions of Auranofin with the Cytoskeleton Proteins of Lung Cancer Cells by Monika ... A wound healing test confirmed their regulation by auranofin as cell migration decreased by 40% while the cell cycle was not ... Auranofin showed better affinity toward proteins than DNA, RNA, and hydrophilic small molecular weight compounds. It can bind ... were exposed to the clinically established gold drug auranofin at concentrations close to the half-maximal inhibitory drug ...
Bioconjugation of the gold drug auranofin to human ferritin yields a potent cytotoxin. JOURNAL OF DRUG DELIVERY SCIENCE AND ... NMR reveals the metabolic changes induced by auranofin in A2780 cancer cells: Evidence for glutathione dysregulation. DALTON ...
  • The brand name Ridaura was coined from the phrase Remission-Inducing Drug + Auranofin. (wikipedia.org)
  • The Mayo clinic is running a clinical trial to research the effects of auranofin and sirolimus on squamous, ras mutated lung adenocarcinoma, and small cell lung cancer. (wikipedia.org)
  • In this study we investigated the altered production of interleukins in arthritic rats and evaluated the effects of auranofin treatment on disease progression and aberrant interleukin production. (aai.org)
  • Auranofin is used to treat rheumatoid arthritis. (wikipedia.org)
  • Auranofin is used, with rest and nondrug therapy, to treat rheumatoid arthritis. (medlineplus.gov)
  • A handout on this topic is available at http://familydoctor.org/familydoctor/en/diseases-conditions/rheumatoid-arthritis.html . (aafp.org)
  • Carol's research looked at combining the cancer drug vermurafenib with auranofin, a gold containing compound previously used for treating rheumatoid arthritis. (pmscienceprizes.org.nz)
  • Subjects were taken off their immuno- suppressive and disease-modifying drugs consisting of methotrexate, 6-mercaptopurine, azathioprine, or auranofin and few 0.1 mg of solubilized type II collagen daily for 1 month and then switched to 0.5 mg for the next 2 months (15). (bronsonvitamins.com)
  • tell your doctor and pharmacist if you are allergic to auranofin or any other drugs. (medlineplus.gov)
  • They tested two drugs called auranofin and palbociclib to stop mesothelioma from spreading in a patient's body. (survivingmesothelioma.com)
  • Drug-screening reveals auranofin induces apoptosis in ovarian cancer cells in vitro. (wikipedia.org)
  • A triethylphosphine gold(i)thioglucose complex (Auranofin) is now in clinical use as an antiarthritic drug, while four-coordinate chelated gold(i) diphosphine complexes such as [Au(DPPE) 2 ]Cl may have a future in the fight against cancer. (chemistryworld.com)
  • Auranofin has been identified in a high-throughput drug screen as 10 times more potent than metronidazole against Entamoeba histolytica, the protozoan agent of human amebiasis. (wikipedia.org)
  • You should not try to become pregnant while taking auranofin or for at least 6 months after discontinuing the drug because it stays in the body for a long time. (medlineplus.gov)
  • Taken together, these results suggest that disease-associated abnormalities in interleukin production may be mediated by different mechanisms with differential sensitivity to the effects of the disease-modifying drug auranofin. (aai.org)
  • The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling. (bvsalud.org)
  • Overall, Auranofin should prevent SARS-CoV-2 infection and inflammatory damages, offering new opportunities as a repurposable drug candidate to treat COVID-19. (bvsalud.org)
  • Auranofin is a gold salt classified by the World Health Organization as an antirheumatic agent. (wikipedia.org)
  • A detailed exploration of the association between inflammation and diabetes revealed the potential of auranofin. (bcm.edu)
  • Auranofin is a safer treatment compared to the more common injectable gold thiolates (gold sodium thiomalate and gold thioglucose), but meta-analysis of 66 clinical trials concluded that it is somewhat less effective. (wikipedia.org)
  • Auranofin protected mice from an otherwise lethal infection with methicillin-resistant S. aureus (MRSA). (wikipedia.org)
  • Among these, we show that Auranofin prevents post-translational modifications of NF-κB effectors and their recruitment into activating complexes in response to SARS-CoV-2 infection or cytokine stimulation. (bvsalud.org)
  • In addition, we demonstrate that Auranofin counteracts several steps of SARS-CoV-2 infection. (bvsalud.org)
  • Auranofin is under investigation as a means of reducing the viral reservoir of HIV that lies latent in the body's T-cells despite treatment with antiretroviral therapy. (wikipedia.org)
  • When mice with Protein kinase Cι (PKCι)-dependent KP adenocarcinoma tumors that exhibited resistance to anti-PD-1 antibody therapy (α-PD-1) were treated with auranofin, the PKCι inhibitor auranofin inhibited KP tumor growth and sensitized these tumors to α-PD-1. (wikipedia.org)
  • Effect of auranofin treatment on aberrant splenic interleukin production in adjuvant arthritic rats. (aai.org)
  • Prophylactic treatment of AA rats with auranofin resulted in a slight reduction in paw edema, a complete normalization of the depressed IL-2 production, and a reduction of the elevated IL-1 production, but had no effect on the depressed IL-3 production. (aai.org)
  • Auranofin may be useful in the prevention and control of Acanthamoeba infections, and in the treatment of primary amoebic meningoencephalitis, caused by pathogenic free-living amoebae Acanthamoeba spp. (wikipedia.org)
  • Auranofin has been reported as potentially beneficial for treatment of COVID-19. (c19early.org)
  • Preliminary results show that auranofin contributed to a decrease in the viral reservoir. (wikipedia.org)
  • However, this observation was not true for auranofin, which increased HMOX1 expression up to 10-fold at high doses. (globalwomenshealthacademy.org)
  • Since the potential anticancer activity of auranofin was discovered, gold compounds have attracted interest with a view to developing anticancer agents that follow cytotoxic mechanisms other than cisplatin. (mdpi.com)
  • 10. Potential Anticancer Activity of Auranofin. (nih.gov)
  • Auranofin is used to treat rheumatoid arthritis. (wikipedia.org)
  • Auranofin is used, with rest and nondrug therapy, to treat rheumatoid arthritis. (medlineplus.gov)
  • We found one drug, auranofin, an oral gold-containing compound approved by the FDA in 1985 to treat rheumatoid arthritis, had an IC50 significantly lower for Entamoeba and equivalent for Giardia to metronidazole. (grantome.com)
  • Auranofin is currently approved for the treatment of rheumatoid arthritis and has been shown to display anti-cancer activity. (nih.gov)
  • The findings support the repurposing of the rheumatoid arthritis medication auranofin for diabetic treatment. (texasbeyond.com)
  • Researchers at Baylor College of Medicine and other institutions revealed that the rheumatoid arthritis medication auranofin might be repurposed to treat diabetes-related symptoms. (texasbeyond.com)
  • We computationally screened a small-molecule dataset and found auranofin, an FDA-approved medication used to treat rheumatoid arthritis, an inflammatory illness," said first and co-corresponding author Dr. Aaron R. Cox, a Baylor professor of medicine-endocrinology, diabetes, and metabolism. (texasbeyond.com)
  • Recently, auranofin, an anti-inflammatory drug, was shown to have therapeutic potential in a number of diseases in addition to rheumatoid arthritis. (nih.gov)
  • Early in the 20th century, Auranofin and gold sodium thiomalate, two drugs with colloidal gold, were used by physicians to treat various ailments, most frequently rheumatoid arthritis (GST). (healthsaf.com)
  • When mice with Protein kinase Cι (PKCι)-dependent KP adenocarcinoma tumors that exhibited resistance to anti-PD-1 antibody therapy (α-PD-1) were treated with auranofin, the PKCι inhibitor auranofin inhibited KP tumor growth and sensitized these tumors to α-PD-1. (wikipedia.org)
  • 7. Auranofin, a thioredoxin reductase inhibitor, causes platelet death through calcium overload. (nih.gov)
  • 16. Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species. (nih.gov)
  • E) Viabilities, dependant on total protein content material, of monocultured A549 cells subjected to the indicated concentrations of 17-AAG, cotreated using the NQO1 inhibitor dicoumarol (10?M) and/or the TXNRD1 inhibitor auranofin (50?nM), for 4?times. (bioxorio.com)
  • While addition from the TXNRD1 inhibitor auranofin induced a moderate increase in success in cells treated with 17-AAG, the hereditary knockout of nearly rescued the lethality, recommending this is the primary NRF2 focus on gene in charge of the rate of metabolism of 17-AAG towards the stronger 17-AAGH2 (Fig. 7G). (bioxorio.com)
  • Drug-screening reveals auranofin induces apoptosis in ovarian cancer cells in vitro. (wikipedia.org)
  • 18. Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species. (nih.gov)
  • Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. (rush.edu)
  • Using an in vitro assay against primary lymphocytes from patients with CLL, auranofin was identified as a drug repurposing candidate for the treatment of CLL. (nih.gov)
  • Subchronic administration of auranofin reduced amyloid-β plaque pathology in a transgenic APP NL-G-F/NL-G-F mouse model. (nih.gov)
  • Most importantly, oral auranofin was effective in vitro and in vivo against E. histolytica and both metronidazole-sensitive and resistan strains of Giardia. (grantome.com)
  • In addition, auranofin may prove to be a future broad spectrum antiparasitic drug as in vitro efficacy has also been demonstrated against Cryptosporidium, Trichomonas, toxoplasmosis, T. brucei, filariasis, and schistosomiasis. (grantome.com)
  • Auranofin is also used sometimes for psoriatic arthritis. (medlineplus.gov)
  • 1. ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines. (nih.gov)
  • Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst. (nih.gov)
  • Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells. (salonmarocainnantes.fr)
  • Surprisingly, no data regarding the effects of auranofin on cognitive deficits in AD mice or the influence of auranofin on Aβ pathology and neuroinflammatory processes are available. (nih.gov)
  • 13. Selective inhibition of endogenous antioxidants with Auranofin causes mitochondrial oxidative stress which can be countered by selenium supplementation. (nih.gov)
  • The Mayo clinic is running a clinical trial to research the effects of auranofin and sirolimus on squamous, ras mutated lung adenocarcinoma, and small cell lung cancer. (wikipedia.org)
  • Auranofin is a gold salt classified by the World Health Organization as an antirheumatic agent. (wikipedia.org)
  • Auranofin protected mice from an otherwise lethal infection with methicillin-resistant S. aureus (MRSA). (wikipedia.org)
  • If you become pregnant while taking auranofin, call your doctor. (medlineplus.gov)
  • Below are the most recent publications written about "Auranofin" by people in Profiles. (rush.edu)
  • Auranofin may cause side effects. (medlineplus.gov)
  • The data demonstrated that auranofin significantly decreased Aβ deposition in the hippocampus and the number of Aβ plaques in the cingulate cortex, but it did not have memory-enhancing effects or induce changes in the expression of the studied proteins. (nih.gov)
  • Our current results highlight the importance of considering further pre-clinical research to investigate the possible beneficial effects of auranofin on the other pathological aspects of AD. (nih.gov)
  • The damaging effects of auranofin on 4T1 Murine mammary carinoma cells. (lafayette.edu)
  • In a cell-based screen, auranofin showed potent activity against replicating and non-replicating M. tuberculosis as well as other gram-positive bacteria. (wikipedia.org)
  • Preliminary results show that auranofin contributed to a decrease in the viral reservoir. (wikipedia.org)
  • In patients on 6 mg auranofin/day, mean steady state blood-gold concentrations were 0.68 ±0.45 mcg/mL (n=63 patients). (nih.gov)
  • Some patients receiving auranofin have noticed changes in the taste of certain foods. (mayoclinic.org)
  • Although Auranofin can be taken orally, Auranofin is often more effective than GST because GST needs to be injected intramuscularly. (healthsaf.com)
  • A human study testing auranofin and other investigational treatments is ongoing in Brazil. (wikipedia.org)
  • We have demonstrated that auranofin inhibits human microglia- and astrocyte-mediated neurotoxicity. (nih.gov)
  • Thus, studies of the pharmacokinetics of auranofin have involved measurement of gold concentrations. (nih.gov)
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking auranofin. (medlineplus.gov)
  • If you notice any other taste changes while you are taking auranofin, it is not necessary to check with your doctor unless you find this effect especially bothersome. (mayoclinic.org)
  • Auranofin is rapidly metabolized and intact auranofin has never been detected in the blood. (nih.gov)