An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.
A thioglucose derivative used as an antirheumatic and experimentally to produce obesity in animals.
A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.
A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
Unstable isotopes of selenium that decay or disintegrate emitting radiation. Se atoms with atomic weights 70-73, 75, 79, 81, and 83-85 are radioactive selenium isotopes.
Inorganic compounds that contain gold as an integral part of the molecule.
The deliberate and methodical practice of finding new applications for existing drugs.
A FLAVOPROTEIN enzyme that catalyzes the oxidation of THIOREDOXINS to thioredoxin disulfide in the presence of NADP+. It was formerly listed as EC 1.6.4.5
The cause of TETANUS in humans and domestic animals. It is a common inhabitant of human and horse intestines as well as soil. Two components make up its potent exotoxin activity, a neurotoxin and a hemolytic toxin.
Insurance designed to compensate persons who lose wages because of illness or injury; insurance providing periodic payments that partially replace lost wages, salary, or other income when the insured is unable to work because of illness, injury, or disease. Individual and group disability insurance are two types of such coverage. (From Facts on File Dictionary of Health Care Management, 1988, p207)
An independent agency within the Executive Branch of the United States Government. It administers a national social insurance program whereby employees, employers, and the self-employed pay contributions into pooled trust funds. Part of the contributions go into a separate hospital insurance trust fund for workers at age 65 to provide help with medical expenses. Other programs include the supplemental social security income program for the aged, blind, and disabled and the Old Age Survivors and Disability Insurance Program. It became an independent agency March 31, 1995. It had previously been part of the Department of Health, Education, and Welfare, later the Department of Health and Human Services. (From United States Government Manual, 1994-95)
Government sponsored social insurance programs.
Gram-negative rods isolated from human urine and feces.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Tumors or cancer of the LUNG.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Benign or malignant neoplasms of the FALLOPIAN TUBES. They are uncommon. If they develop, they may be located in the wall or within the lumen as a growth attached to the wall by a stalk.
Tumors or cancer of the PERITONEUM.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.
A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.

Does sulphasalazine cause drug induced systemic lupus erythematosus? No effect evident in a prospective randomised trial of 200 rheumatoid patients treated with sulphasalazine or auranofin over five years. (1/105)

BACKGROUND: Sulphasalazine (SSZ) has been reported to cause drug induced systemic lupus erythematosus (SLE), but diagnosis of this complication in the context of rheumatoid arthritis (RA) is difficult. OBJECTIVE: To determine prospectively: (1) if patients become seropositive for antinuclear antibodies (ANA) during prolonged treatment with SSZ without clinical evidence of SLE; (2) if ANA positive patients develop more adverse reactions than ANA negative patients; (3) if drug induced SLE was identified in this cohort. METHODS: 200 patients enrolled in a randomised prospective trial of SSZ and auranofin (AUR) were followed up for five years. Baseline and annual ANA results were collected along with information on drug toxicity and reasons for discontinuation of treatment. RESULTS: Over five years 24 patients stopped taking SSZ and 49 AUR because of side effects. Of the features common to SLE, rash developed in nine SSZ patients and 11 AUR treated patients and mouth ulcers in three and four patients respectively. Six SSZ treated patients and three treated with AUR developed leucopenia, which promptly resolved with drug withdrawal. No adverse event was ascribed to drug induced SLE. Of the 72 SSZ treated patients who were ANA negative or weakly positive at outset, 14 (19%) became strongly ANA positive compared with 11 (14%) of 80 AUR patients. Patients ANA positive at baseline or who became ANA positive were not more likely to develop drug toxicity or to withdraw from treatment than those ANA negative throughout. CONCLUSION: ANA positivity is common in patients with RA, but the presence or development of ANA did not increase the likelihood of withdrawing from treatment. No case of drug induced SLE was seen over five years in this study.  (+info)

Effects of anti-rheumatic gold salts on NF-kappa B mobilization and tumour necrosis factor-alpha (TNF-alpha)-induced neutrophil-dependent cytotoxicity for human endothelial cells. (2/105)

We have previously shown that the gold-containing disease-modifying anti-rheumatic drugs, auranofin (AF) and gold sodium aurothiomalate (GSTM) reduce human umbilical vein endothelial cell (HUVEC) adhesion molecule expression and neutrophil (PMN) adherence. AF diminishes E-selectin and intercellular adhesion molecule-1 (ICAM-1) on cytokine-activated HUVEC, while GSTM decreases only E-selectin. Since tight adhesion is critical for PMN to damage EC, we tested whether these drugs modulated human PMN-mediated injury to TNF-alpha-activated HUVEC in vitro (as measured by 51Cr release). Here we show that TNF-alpha caused a prominent PMN-mediated cytotoxicity that was dose-dependently reduced when AF and GSTM were added to the assay system. We also found that a potent inhibitor of NF-kappaB, pyrrolidine dithiocarbamate (PDTC) in a dose-dependent manner impaired TNF-alpha-induced cytotoxicity, indicating a role of NF-kappaB activation in cytokine-induced endothelial injury. To examine the effects of AF and GSTM on TNF-alpha-induced NF-kappaB activation this was measured in HUVEC nuclear extracts by an electrophoretic mobility shift assay. AF, but not GSTM, decreased TNF-alpha-induced NF-kappaB activation in HUVEC. Thus, in this in vitro model of vasculitis, AF and GSTM dose dependently reduced TNF-alpha-mediated neutrophil-dependent cytotoxicity for HUVEC, and AF, but not GSTM, inhibited NF-kappaB mobilization, thereby providing possible mechanisms for effects of AF and GSTM.  (+info)

Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase. (3/105)

Gold compounds are used in the treatment of rheumatoid arthritis. NF-kappa B is a transcription factor implicated in the expression of many inflammatory genes. NF-kappa B is activated by signal-induced phosphorylation and subsequent degradation of inhibitory I kappa B (inhibitory protein that dissociates from NF-kappa B) proteins, and a multisubunit I kappa B kinase (IKK) has been identified previously. We tested the effect of various gold compounds on the activation of NF-kappa B and IKK in LPS-stimulated RAW 264.7 mouse macrophages. A lipophilic gold compound, auranofin, suppressed the LPS-induced increase of nuclear kappa B-binding activity, degradation of I kappa B proteins, and IKK activation. Auranofin also blocked IKK activation induced by TNF and PMA/ionomycin, suggesting that the target of auranofin action is common among these diverse signal pathways. In vitro IKK activity was suppressed by addition of hydrophilic gold compounds, such as aurothiomalate, aurothioglucose, and AuCl3. Other thiol-reactive metal ions such as zinc and copper also inhibited IKK activity in vitro, and induction of IKK in LPS-stimulated macrophages. In vitro IKK activity required the presence of reducing agent and was blocked by addition of thiol group-reactive agents. Two catalytic subunits of IKK complex, IKK alpha and IKK beta, were both inhibited by these thiol-modifying agents, suggesting the presence of a cysteine sulfhydryl group in these subunits, which is critical for enzyme activity. The antiinflammatory activity of gold compounds in the treatment of rheumatoid arthritis may depend on modification of this thiol group by gold.  (+info)

Aggressive treatment in early rheumatoid arthritis: a randomised controlled trial. On behalf of the Rheumatic Research Foundation Utrecht, The Netherlands. (4/105)

OBJECTIVES: To compare three therapeutic strategies using slow acting antirheumatic drugs (SAARDs) in early rheumatoid arthritis (RA), for their disease modifying properties, toxicity, and lag time until treatment effect. METHODS: Patients with recent onset RA from six hospitals were randomly assigned to immediate initiation of one of three treatment strategies: (I) a "mild SAARD with a long lag time" (hydroxychloroquine, if necessary replaced by auranofin); (II) a "potent SAARD with a long lag time" (intramuscular gold, if necessary replaced by D-penicillamine); (III) a "potent SAARD with a short lag time" (methotrexate, if necessary replaced by sulfasalazine). Comparisons included two years of follow up. RESULTS: All SAARD strategies reduced mean disease activity. A greater percentage of patients improved clinically with strategies II and III than with strategy I: percentages of patients improved on joint score with strategies II and III (79% and 82%, respectively), which was statistically different from strategy I (66%). The same was true for remission percentages: 31% and 24% v 16%, respectively). Longitudinal analysis showed significantly less disability with strategy III, and a lower erythrocyte sedimentation rate with strategy II than with strategy I. In addition, radiological damage after one and two years, was significantly lower in strategies II and III (at two years median scores were 11 and 10 v 14 in strategy I, p<0.05). Toxicity was increased in strategy II compared with the other strategies. CONCLUSION: Strategy III, comprising methotrexate or sulfasalazine, produced the best results weighing effectiveness and toxicity. Strategy I (hydroxychloroquine or auranofin) was slightly less effective, and strategy II (intramuscular gold or D-penicillamine) was associated with increased toxicity.  (+info)

Inhibition of interleukin-12 production by auranofin, an anti-rheumatic gold compound, deviates CD4(+) T cells from the Th1 to the Th2 pathway. (5/105)

1. Interleukin-12 (IL-12) may play a central role in the development and progression of rheumatoid arthritis by driving the immune response towards T helper 1 (Th1) type responses characterized by high IFN-gamma and low IL-4 production. In this study we investigated the effect of auranofin (AF), an anti-rheumatic gold compound, on IL-12 production in mouse macrophages and dendritic cells, and studied whether AF-mediated inhibition of IL-12 production could regulate a cytokine profile of antigen (Ag)-primed CD4(+) Th cells. 2. Treatment with AF significantly inhibited IL-12 production in lipopolysaccharide (LPS)-stimulated macrophages and also in CD40L-stimulated dendritic cells. AF-pretreated macrophages reduced their ability to induce IFN-gamma and increased the ability to induce IL-4 in Ag-primed CD4(+) T cells. AF did not influence the cell surface expression of the class II MHC molecule and the costimulatory molecules CD80 and CD86. 3. Addition of recombinant IL-12 to cultures of AF-pretreated macrophages and CD4(+) T cells restored IFN-gamma production in Ag-primed CD4(+) T cells. 4. The in vivo administration of AF resulted in the inhibition of IL-12 production by macrophages stimulated in vitro with LPS or heat-killed Listeria monocytogenes (HKL), leading to the inhibition of Th1 cytokine profile (decreased IFN-gamma and increased IL-4 production) in Ag-primed CD4(+) T cells. 5. These findings may explain some known effects of AF including anti-rheumatic effects and the inhibition of encephalitogenicity, and point to a possible therapeutic use of AF in the Th1-mediated immune diseases such as autoimmune diseases.  (+info)

Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative. (6/105)

1 Gold(I)-thiolate drugs are compounds that specifically interact with thiol and/or selenol groups and are essentially utilized in the treatment of rheumatoid arthritis. 2 Considering the importance of thiol groups in regulating mitochondrial membrane permeability, the effects of auranofin (S-triethylphosphinegold(I)-2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranoside) , a second-generation gold drug, were studied on mitochondria isolated from rat liver. 3 Auranofin, at submicromolar concentrations, was able to induce the mitochondrial membrane permeability transition observed as swelling and loss of membrane potential. Both events are completely inhibited by cyclosporin A, the specific inhibitor of mitochondrial permeability transition. Calcium ions and energization by succinate are required for the occurrence of permeability transition. 4 By interacting with the active site selenol group, auranofin results as an extremely potent inhibitor of mitochondrial thioredoxin reductase, both isolated and in its mitochondrial environment. 5 It is concluded that auranofin, in the presence of calcium ions, is a highly efficient inducer of mitochondrial membrane permeability transition, potentially referable to its inhibition of mitochondrial thioredoxin reductase.  (+info)

Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit. (7/105)

Antirheumatic gold compounds have been shown to inhibit NF-kappaB activation by blocking IkappaB kinase (IKK) activity. To examine the possible inhibitory mechanism of gold compounds, we expressed wild type and mutant forms of IKKalpha and beta subunits in COS-7 cells and determined the effect of gold on the activity of these enzymes both in vivo and in vitro. Substitution of Cys-179 of IKKbeta with alanine (C179A) rendered the enzyme to become resistant to inhibition by a gold compound auranofin, however, similar protective effect was not observed with an equivalent level of IKKalpha (C178A) mutant expressed in the cells. Auranofin inhibited constitutively active IKKalpha and beta and variants; IKKalpha (S176E, S180E) or IKKbeta (S177E, S181E), suggesting that gold directly cause inhibition of activated enzyme. The different inhibitory effect of auranofin on IKKalpha (C178A) and IKKbeta (C179A) mutants indicates that gold could inhibit the two subunits of IKK in a different mode, and the inhibition of NF-kappaB and IKK activation induced by inflammatory signals in gold-treated cells appears through its interaction with Cys-179 of IKKbeta.  (+info)

Prospective trial comparing the use of sulphasalazine and auranofin as second line drugs in patients with rheumatoid arthritis. (8/105)

Two hundred patients with rheumatoid arthritis were studied in a prospective open trial comparing treatment with sulphasalazine and auranofin in patients with active disease over 12 months. The two drugs improved many parameters of disease activity at 12, 24, and 48 weeks. At 12 weeks, the group treated with sulphasalazine had a lower platelet count (Mann-Whitney U test), erythrocyte sedimentation rate, and articular index, with a greater decrease in erythrocyte sedimentation rate (Students t test) and C reactive protein between 0 and 12 weeks. There were no significant differences between sulphasalazine and auranofin treatment after 24 and 48 weeks. Life table analysis showed no significant differences in the rate of side effects which caused treatment to be stopped. Sulphasalazine works more rapidly, may be a more effective disease modifying antirheumatic drug, and is as well tolerated as auranofin.  (+info)

Auranofin is a thiol-reactive gold (I)-containing compound with potential asa chemotherapeutic. Auranofin has the capacity to selectively inhibit endogenous antioxidant enzymes thioredoxin reductase (TrxR) and glutathione peroxidase (GPx), resulting in oxidative stress and the initiation of a pro-apoptotic cascade. The effect of Auranofin exposure on TrxR and GPx, and the potential for cellular protection through selenium supplementation was examined in the non-cancerous human cell line Swan-71. Auranofin exposure resulted in a concentration dependent differential inhibition of selenoprotein antioxidants. Significant inhibition of TrxR was observed at 20nM Auranofin with inhibition of GPx from 10µM. Significant increases in reactive oxygen species (ROS) were associated with antioxidant inhibition at Auranofin concentrations of 100nM (TrxR inhibition) and 10µM (TrxR and GPx inhibition), respectively. Evaluation of mitochondrial respiration demonstrated significant reductions in routine and ...
TY - JOUR. T1 - Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension. AU - Lewis, Mark G.. AU - Dafonseca, Sandrina. AU - Chomont, Nicolas. AU - Palamara, Anna T.. AU - Tardugno, Maria. AU - Mai, Antonello. AU - Collins, Matt. AU - Wagner, Wendeline L.. AU - Yalley-Ogunro, Jake. AU - Greenhouse, Jack. AU - Chirullo, Barbara. AU - Norelli, Sandro. AU - Garaci, Enrico. AU - Savarino, Andrea. PY - 2011/7/17. Y1 - 2011/7/17. N2 - Objectives: A small pool of long-lived memory CD4 T cells harboring the retroviral genome is one main obstacle to HIV eradication. We tested the impact of the gold compound, auranofin, on phenotype and viability of CD4 + T cells in vitro, and on persistence of lentiviral reservoir cells in vivo. Design: In-vitro and in-vivo study. The pro-differentiating effect of auranofin was investigated in human primary CD4 + T cells, and its capacity to deplete the viral DNA (vDNA) reservoir was tested ...
Clostridioides difficile is the leading cause of nosocomial infections and a worldwide urgent public health threat. Without doubt, there is an urgent need for new effective anticlostridial agents due to the increasing incidence and severity of C. difficile infection (CDI). The aim of the present study is to investigate the in vivo efficacy of auranofin (rheumatoid arthritis FDA-approved drug) in a CDI mouse model and establish an adequate dosage for treatment. The effects of increased C. difficile inoculum, and pre-exposure to simulated gastric intestinal fluid (SGF) and simulated intestinal fluid (SIF), on the antibacterial activity of auranofin were investigated. Auranofins in vitro antibacterial activity was stable in the presence of high bacterial inoculum size compared to vancomycin and fidaxomicin. Moreover, it maintained its anti-C. difficile activity after being exposed to SGF and SIF. Upon testing in a CDI mouse model, auranofin at low clinically achievable doses (0.125 mg/kg and 0.25 ...
PRIMARY OBJECTIVES:. I. To demonstrate the feasibility of conducting a 10-patient pilot study in asymptomatic ovarian cancer patients with cancer antigen (CA 125) elevation.. SECONDARY OBJECTIVES:. I. To explore whether oral gold therapy either stabilizes or lowers the CA 125 level and maintains patients in an asymptomatic state and to provide descriptive data on tumor response and duration of response.. II. To acquire qualitative data on patients perceptions of learning of CA 125 elevation.. III. To explore whether immunohistochemical staining for PKC iota expression in resected tumor samples appears to be associated with clinical outcomes with auranofin.. OUTLINE:. Patients receive auranofin orally (PO) twice daily (BID) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed up every 6 months for 2 years. ...
High-field proton NMR spectroscopic analysis of urine and plasma has been employed to study the biochemical effects and nephrotoxic action of an intramuscular dose of auranofin in rats. Auranofin induced a characteristic profile of proximal tubular damage as evidenced by aminoaciduria, lactic aciduria and increased urinary acetate concentrations. In addition, ethanol was detectable in both urine and plasma obtained from auranofin-treated rats. Auranofin-mediated elevations in the plasma and urine concentrations of 3-D-hydroxybutyrate indicated an increased utilisation of fats for fuel in rats treated with this novel therapeutic agent.. ...
TY - JOUR. T1 - Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition. AU - Caroli, Antonia. AU - Simeoni, Silvia. AU - Lepore, Rosalba. AU - Tramontano, Anna. AU - Via, Allegra. N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUK-I1-012-43 Acknowledgements: We thank the members of the Fondazione Roma Research Unit led by Prof. Maurizio Brunori for useful discussions and Prof. Arthur Lesk for critically reading the manuscript. This work was partially supported by Award number KUK-I1-012-43 made by King Abdullah University of Science and Technology (KAUST), FIRB Proteomica, Ministery of Health Grant Contract No. Onc_Ord 25/07, Fondazione Roma and the IIT SEED project. This publication acknowledges KAUST support, but has no KAUST affiliated authors.. PY - 2012/1. Y1 - 2012/1. N2 - Schistosoma mansoni and Plasmodium falciparum are pathogen parasites that spend part of their ...
Professional guide for Auranofin. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.. ...
Both amebiasis and giardiasis are currently treated with the antibiotic metronidazole, which has side effects that include nausea, vomiting, dizziness and headache.. The new drug, auranofin, has been used as a twice-daily oral therapy for adults with rheumatoid arthritis since 1985, and has been shown to be safe at that dosage. The researchers laboratory studies indicated that auranofin would be about ten times more potent than the current treatment for dysentery, meaning it could be given at low dose, and on a one-time or limited basis.. This is a drug that you can find in every country, said Debnath, a postdoctoral fellow at UCSF who led the research and is first author on the paper. Based on the dosage were seeing in the lab, this treatment could be sold at about $2.50 per dose, or lower. That cost savings could make a big difference to the people who need it the most. International Collaboration. The research stemmed from a joint effort among several labs at UCSF that are affiliated ...
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market. ...
Small cell lung cancer (SCLC) is a highly lethal malignancy with the 5-year survival rate of less than 7%. Chemotherapy-resistance is a major challenge for SCLC treatment in clinic. In the study, we...
Through the exceptional capabilities and caring spirit of its people, Vanderbilt will lead in improving the healthcare of individuals and communities regionally, nationally and internationally. We will combine our transformative learning programs and compelling discoveries to provide distinctive personalized care ...
The goals of this TRND project are to develop a treatment for CLL and to develop a novel paradigm for repurposing drugs for rare diseases.
The Georgia State University researchers explained that Auranofin also dramatically reduced the expression of cytokines - signaling proteins that draw immune cells to the site of infection- caused by SARS-CoV-2. Normally, the immune system works by fighting off invading pathogens and repairing damage to the bodys tissues.. But many coronavirus-infected patients who die do so because of something called a cytokine storm, in which the bodys immune response spirals out of control, killing healthy tissue and leading to organ failure.. According to Kumar, the research seems to indicate that the drug not only could inhibit the replication of SARS-CoV-2, mitigating the infection, but also reduce the associated lung damage that often leads to severe respiratory distress and even death.. Precious metal has been used in medicine since ancient times, and more recently, scientists have explored gold compounds as effective treatments for HIV, cancer, neurodegenerative disorders and parasitic and ...
2YAU: A Gold-Containing Drug Against Parasitic Polyamine Metabolism: The X-Ray Structure of Trypanothione Reductase from Leishmania Infantum in Complex with Auranofin Reveals a Dual Mechanism of Enzyme Inhibition.
Purpose:Cancer cells (relative to normal cells) demonstrate increased steady-state levels of hydroperoxides that are compensated for by increased glucose and hydroperoxide metabolism. The current study determined if inhibitors of glucose and hydroperoxide metabolism could induce chemo-radio-sensitization by enhancing oxidative stress in lung cancer cells. Experimental Design:A549 and NCI-H292 human lung carcinoma cells were treated with 2-Deoxy-D-glucose (2DG) combined with carboplatin (carbo) + ionizing radiation (IR). Lung cancer cells were further sensitized with inhibitors of glutathione- and thioredoxin-dependent metabolism [buthionine sulfoximine (BSO) and auranofin (Au), respectively] in vitro and in vivo. Results:When 2DG was combined with carbo+IR, clonogenic cell killing was enhanced in A549 and NCI-H292 cells and this combination was more effective than paclitaxel+carbo+IR. The thiol antioxidant (N-acetylcysteine, NAC) was capable of protecting cancer cells from 2DG+carbo-induced cell ...
Results from the trial have been presented on a number of previous occasions, including at AIDS 2018, CROI 2019, and the 2019 HIV Persistence Workshop (see abstract OP 8.6 in the abstract book and the report from NATAP). [5, 6, 7, 8]. Results from participants who received auranofin were also the subject of a published paper last year. Overall, declines in HIV DNA levels (a surrogate measure of the HIV reservoir) were found to be greatest among recipients of the multiple interventions in group six. [9]. The original study design did not include an analytical treatment interruption (ATI), but the protocol was later revised and 25 of the participants underwent an ATI approximately 2.5 years after the end of the 48-week study period (during which the interventions were administered).. The presentation at last years HIV Persistence Workshop reported that two participants in group six and one in group three displayed undetectable HIV viral loads after the ATI. However, after around 16 weeks the two ...
Title: Protein Targets for Anticancer Gold Compounds: Mechanistic Inferences. VOLUME: 11 ISSUE: 10. Author(s):Chiara Gabbiani and Luigi Messori. Affiliation:MetMed Lab, Department of Chemistry, University of Florence, via della Lastruccia, 3, 50019 Sesto Fiorentino, Florence, Italy.. Keywords:Gold compounds, cancer, proteins, metal-protein adducts, phosphine complexes, antiproliferative properties, dithiocarbamate complexes, thiosugar ligand, X-ray diffraction, cytochrome c. Abstract: Gold compounds form an interesting class of antiproliferative agents of potential pharmacological use in cancer treatment. Indeed, a number of gold compounds, either gold(III) or gold(I), were recently described and characterised that manifested remarkable cytotoxic properties in vitro against cultured cancer cells; for some of them encouraging in vivo results were also reported toward a few relevant animal models of cancer. The molecular mechanisms through which gold compounds exert their biological effects are ...
In recent years, gold compounds have gained more and more attentions in the design of new metal anticancer drugs. Numerous researches have reported that gold compounds, in addition to their widely studied cytotoxic antitumor effects, also reverse tumor immune escape and directly facilitate the functions of immune cells, leading to enhanced anticancer effects. This review mainly summarizes our current understandings of antitumor effects of gold drugs and their relationships with various aspects of antitumor immunity, including innate immunity, adaptive immunity, immunogenic cell death, and immune checkpoints, as well as their roles in adverse effects. Some recent examples of anticancer gold compounds are highlighted. The property of gold compounds is expected to combine with anticancer immunotherapy, such as immune checkpoint inhibitors, to develop new anticancer therapeutic strategies.
Gold compounds have been employed for the treatment of rheumatoid arthritis (RA) since Forestier pioneered their use for this purpose in 1929. Subsequent randomized trials confirmed the effectiveness of gold in RA (seebelow). Gold has also been used
Shop Thioredoxin/glutathione peroxidase ELISA Kit, Recombinant Protein and Thioredoxin/glutathione peroxidase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Cancer stem cells (CSCs) exhibit lower intracellular reactive oxygen species (ROS) levels than non-CSCs, which may be due to the increased expression of free radical scavenging systems. Exogenous agents may be useful to increase ROS and selectively kill CSCs by oxidative stress. Here we tested a combination approach to increase ROS as an effective strategy to eradicate breast CSCs and metastases. Buthionine sulfoximine (BSO) and auranofin (AU) were used to deplete glutathione (GSH) and inhibit thioredoxin reductase (TR), respectively, while mitochondrial-targeted decyltriphenylphosphonium (dTPP) was used to elevate ROS levels. In vitro clonogenicity assays using SUM159 cells showed that treatment with dTPP alone resulted in ,30% survival, while AU+BSO, BSO+dTPP and AU+BSO+dTPP all resulted in ,1% survival. These effects were reversible with N-acetylcysteine pre-treatment. The Aldefluor+ (CSC) population was also measured following drug treatment in vitro. dTPP or AU treatment alone resulted in ...
...A team of researchers from UCSF and UC San Diego has identified an app...Based on these results the team has received Orphan Drug Status for t...The findings which showed that auranofin inhibited growth of the para...The combination of an off-patent drug and decades of clinical safety d...,Lab,tests,show,arthritis,drug,effective,against,global,parasite,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
We prefer compounds that require metabolic activation, although standards that are active in themselves will be accepted if they have otherwise valuable properties. We require knowing the active metabolite, and we prefer compounds where the metabolite is stable and can be independently tested in order to verify the mechanism of toxicity as well as of metabolic activation in the test cell line ...
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Rick and Parker reveal that theres bad blood in the most intense conversation yet. Parker admits that his feud with Tony is often worse than whats portrayed on the show. Then, Rick and his crew lighten the mood with wild tales of life on the claim.
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Date:. May 20, 2012. Source:. University of California, San Diego Health Sciences. Summary:. An existing drug has been found to be effective against Entamoeba histolytica. This parasite causes amebic dysentery and liver abscesses and results in the death of more than 70,000 people worldwide each year.. Research by a collaborative group of scientists from UC San Diego School of Medicine, UC San Francisco and Wake Forest School of Medicine has led to identification of an existing drug that is effective against Entamoeba histolytica. This parasite causes amebic dysentery and liver abscesses and results in the death of more than 70,000 people worldwide each year.. Using a high-throughput screen for drugs developed by the research team, they discovered that auranofin -- a drug approved by the US Food and Drug Administration 25 years ago for rheumatoid arthritis -- is very effective in targeting an enzyme that protects amebae from oxygen attack (thus enhancing sensitivity of the amebae to reactive ...
To find new solutions to this problem, a Purdue University researcher has developed a new method of drug repurposing, which helps to identify three drugs, auranofin, ebselen, and 5-fluoro-2-deoxyuridine (FdUrd), as potent antimicrobial agents against Gram-positive pathogens such as MRSA. Although these drugs had other FDA approved indications, expanding their use to antimicrobial therapy would increase medication options for infections. Since these drugs are either FDA-approved drugs or clinically safe molecules that have an established pharmacokinetic and safety profile, it will significantly reduce the time and cost required to bring these drugs to clinical trials. Furthermore, they have greater oral bioavailability, potent bacterial killing activity, very low frequency of resistance, suppression of bacterial virulence factors and toxin production, potent anti-biofilm activity, and good penetration and killing of intracellular MRSA. These drugs can be used as antimicrobial medicines in ...
Comment: The publication reports results that were obtained using a mouse model. The News Release states that a Phase I clinical trial is under way at the Mayo Clinic, but this trial isnt mentioned in the full text of the publication in Cancer Research. According to MedicineNet.com, aurothiomalate is a gold-containing chemical (salt) used in treating rheumatoid arthritis ...
Among the twenty gold-based compounds Benoit Bertrand synthesized, two of them presented interesting selective toxicity for cancer cells compared to healthy cells and tissues and deserve further investigations as potential anticancer drugs. Currently, platinum-based compounds are present in the majority of the chemotherapeutic cocktails. However, despite their clinical success, platinum-based drugs present several limitations including numerous and severe side effects. A strategy envisaged to overcome these limitations is the replacement of platinum by other transition metals. Among the different metals tested over the years, gold compounds have been shown to be promising as they can overcome resistance to cisplatin due to their different modes of action. In his thesis, Bertrand presents the synthesis of different types of gold-based complexes including gold(I)-N-heterocyclic carbenes (NHC), (C^N) cyclometalated gold(III) complexes as well as heterobimetallic complexes bearing a gold(I)-NHC ...
Buy Atmel ATMEGA1281-16AUR at Win Source. Source ATMEGA1281-16AUR Price,Find ATMEGA1281-16AUR Datasheet ,Check ATMEGA1281-16AUR In stock & RFQ from online electronic stores.
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Low-density lipoprotein is recognized as a primary vascular risk factor. However, recent data favor apolipoprotein (apo)B and apoA-I as risk factors with higher predictive values than conventional lipids. We investigated how leisure-time physical activity relates to the serum apoB/apoA-I ratio in...
PRIMARY OBJECTIVES: I. To determine the maximally tolerated dose (MTD) of ATM (gold sodium thiomalate) plus sirolimus. SECONDARY OBJECTIVES: I. To describe the adverse event profile associated with this treatment combination. II. To preliminarily evaluate the response rate, time to progression, progression-free survival and overall survival of patients treated with this treatment combination. TERTIARY OBJECTIVES: I. To evaluate tumor biomarkers of protein kinase C (PKCι) and mammalian Target Of Rapamycin (mTOR) signaling activity as predictors of response to ATM/sirolimus therapy. II. To evaluate the use of surrogate biomarkers of PKCι and mTOR inhibition in peripheral blood lymphocytes (PBLs) to monitor response to ATM/sirolimus therapy. OUTLINE: This is a dose-escalation study. Patients receive sirolimus orally (PO) once daily (QD) on days 1-28 and gold sodium thiomalate intramuscularly (IM) on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression or ...
Physician reviewed gold sodium thiomalate patient information - includes gold sodium thiomalate description, dosage and directions.
Medscape - Rheumatoid arthritis dosing for Aurothiomalate sodium, Myochrysine (gold sodium thiomalate), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
Looking for gold sodium chloride? Find out information about gold sodium chloride. sodium gold chloride Explanation of gold sodium chloride
0137] The at least one used anti-inflammatory, antiproliferative, antiangiogenic, antirestenotic (anti-restenosis), antineoplastic, antimigrative and/or antithrombogenic active agent is preferably selected from the group comprising or consisting of: abciximab, acemetacin, acetylvismione B, aclarubicin, ademetionine, adriamycin, aescin, afromosone, akagerine, aldesleukin, amidorone, aminoglutethimide, amsacrine, anakinra, anastrozole, anemonin, anopterine, antimycotics, antithrombotics, apocymarin, argatroban, aristolactam-All, aristolochic acid, ascomycin, asparaginase, aspirin, atorvastatin, auranofin, azathioprine, azithromycin, baccatin, bafilomycin, basiliximab, bendamustine, benzocaine, berberine, betulin, betulinic acid, bilobol, bisparthenolidine, bleomycin, bombrestatin, Boswellic acids and its derivatives, bruceanol A, B and C, bryophyllin A, busulfan, antithrombin, bivalirudin, cadherins, camptothecin, capecitabine, o-carbamoyl-phenoxyacetic acid, carboplatin, carmustine, celecoxib, ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Sodium aurothiomalate (INN, known in the United States as gold sodium thiomalate) is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Along with an orally-administered gold salt, auranofin, it is one of only two gold compounds currently employed in modern medicine. It is primarily given once or twice weekly by intramuscular injection for moderate-severe rheumatoid arthritis although it has also proven itself effective in treating tuberculosis. Its most common side effects are digestive (mostly dyspepsia, mouth swelling, nausea, vomiting and taste disturbance), vasomotor (mostly flushing, fainting, dizziness, sweating, weakness, palpitations, shortness of breath and blurred vision) or dermatologic (usually itchiness, rash, local irritation near to the injection site and hair loss) in nature, although conjunctivitis, blood dyscrasias, kidney damage, joint pain, muscle aches/pains and liver dysfunction are also common. Less commonly, it can cause GI bleeds, dry mucous ...
Schistosomiasis is a tropical disease associated with high morbidity and mortality, currently affecting over 200 million people worldwide. Praziquantel is the only drug used to treat the disease, and with its increased use the probability of developing drug resistance has grown significantly. The Schistosoma parasites can survive for up to decades in the human host due in part to a unique set of antioxidant enzymes that continuously degrade the reactive oxygen species produced by the hosts innate immune response. Two principal components of this defense system have been recently identified in S. mansoni as thioredoxin/glutathione reductase (TGR) and peroxiredoxin (Prx) and as such these enzymes present attractive new targets for anti-schistosomiasis drug development. Inhibition of TGR/Prx activity was screened in a dual-enzyme format with reducing equivalents being transferred from NADPH to glutathione via a TGR-catalyzed reaction and then to hydrogen peroxide via a Prx-catalyzed step. A fully ...
Gold Flotation Production Line. Process Introduction. The flotation meth od is a widel y used technique for the recovery of gold from gold-containing copper ores, base metal ores, copper-nickel ores, platinum group ores and many other ores where other processes are not applicable. Flotation is also used for the removal of interfering impurities before hydrometallurgical treatment, for ...
This statistic displays the top anti-rheumatics worldwide by revenue in 2016 and a projection for 2022. The drug Enbrel from Pfizer, Amgen, and Takeda is expected to generate domr 5.3 billion U.S. dollars in revenue in 2022. Anti-rheumatic drugs is used to treat and slow the progress of rheumatoid arthritis. Rheumatoid arthritis is an autoimmune disease that principlally attacks the joints but also impacts tissues and organs.
Inel din aur cu diamante (INOYD0014666). Material: Aur. Culoare aur: Alb. Tip piatra: Diamante si safir. Vezi mai multe detalii pe site.
I feel like i can see a second line, but Im not very sure. Can anyone tweak this for me please and give me your thoughts? Thank you
Elephant specific information, if available, is in blue.. Chemistry - A water soluble gold salt, aurothioglucose contains approximately 50% gold. It is practically insoluble in alcohol and insoluble in vegetable oils. The commercial product is a 5% (50 mg/ml) suspension in sesame oil, 2% aluminum monostearate, and propylparaben is added as a preservative.. Storage/Stability/Compatibility - Protect from light and store between 15-30° C; avoid freezing. A five year expiration date is assigned after manufacture. Do not mix with any other compound when injecting.. Pharmacology - Aurothioglucose has anti-inflammatory, antirheumatic, immunomodulating, and antimicrobial (in vitro) effects. The exact mechanisms for these actions are not well understood. Gold is taken up by macrophages where it inhibits phagocytosis and may inhibit lysoso-mal enzyme activity. Gold also inhibits the release of histamine, and the production of prostaglandins. While gold does have antimicrobial effects in vitro, it is not ...
REFERENCESK. Kitamura (1981) Therapeutic Effect of Pyritinol on Sequelae of Head Injuries J Int Med Res 9, 215-21.. G. Dalle Ore et al (1980) The Influence of the Administration of Pyritinol on the Clinical Course of Traumatic Coma, J Neuroserg Sci 24, 1-8.. E.M. Lemmel (1993) Comparison of Pyritinol and Auranofin in the Treatment of Rheumatoid Arthritis Br J Rheumatol 32, 375-82.. I. Hindmarch et al (1990) Psychpharmacalogical Effects of Pyritinol in Normal Volunteers Neuropsychobiol 24, 159-64.. A. Pavlik & J. Pilar (1989) Protection of Cell Proteins Against Free-Radical Attack by Nootropic Drugs: Scavenger Effects of Pyritinol Confirmed by Electron Spin Resonance Spectroscopy Nueropharmacol 28, 557-61.. S. Hoyer et al (1977) Effect of Pyritinol-HCL on Blood Flow and Oxidative Metabolism of the Brain in Patients with Dementia Arzneim Forsch/Drug Res 27, 671-74.. J. Elferink & B. de Koster (1993) Differential Stimulation of Neutrophil Functions by Pyritinol Int J Immunopharmac 15, ...
Gold, Chemical Element - uses, elements, examples, metal ... , Gold has been called the most beautiful of all chemical elements. Its beauty has made it ... Roman historian Pliny the Elder ( A.D. 23-79), for example, describes gold-mining locations. ... The most common compounds of gold are the tellurides.. Gold (Au) - Chemical properties, Health and Environmental ... , The most common gold compounds are auric chloride (AuCl3) and chlorauric acid ... comes from gravels and quarts veins or is associated with pyrites deposits.. Gold - Wikipedia , Gold is a chemical element with the symbol Au (from Latin: aurum) and atomic number 79, ... Less commonly, it occurs in minerals as gold compounds, often with tellurium (gold tellurides). Gold is resistant to most ... A good example is Au(CN)2, which is the soluble form of gold encountered in mining. The binary gold halides .... What are the elements and compounds of gold being mined ... , 22 Oct 2019 ... When we mine gold, we are mining GOLD: it is ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Gold-containing preparations which improve the adhesiveness, guarantee an esthetic appearance, and should make possible a saving in gold consumption are needed for the production of intermediate layers for the facings of fired on alloys in the dental art with ceramic compositions. This is accomplished with preparation that contain 50 to 94% gold powder having a particle size |30μ, 5-40% binder made of organic solvent and resin components are 1-20% of a metal powder whose particle size is greater than of the gold powder used and whose melting temperature is above that of gold.
A teenage girl who thought she was just lazy has overcome leukaemia after recognising her lethargic symptoms in a character in a Cameron Diaz film.. Alex Cooper, 17, was stunned after she noticed she was suffering the same symptoms as a character dying from cancer while watching the film My Sisters Keeper.. The film is about a young girl who is brought into the world to be a genetic match for her older sister, who suffers from acute promyelocytic leukaemia.. Alex had been suffering fatigue, numerous headaches, her stomach had swollen and she noticed bruises appearing all over her body.. She had originally put her symptoms down to being a lazy teenager and didnt tell anyone because she was worried about making a fuss.. But thanks to the information in the film the academically-gifted teenager, who is aiming to study at Cambridge, finally realised she needed to see a specialist.. Alex, of Bredgar, Kent, went to see her GP in October 2010 and was diagnosed with chronic myeloid leukaemia ...
A teenage girl who thought she was just lazy has overcome leukaemia after recognising her lethargic symptoms in a character in a Cameron Diaz film.. Alex Cooper, 17, was stunned after she noticed she was suffering the same symptoms as a character dying from cancer while watching the film My Sisters Keeper.. The film is about a young girl who is brought into the world to be a genetic match for her older sister, who suffers from acute promyelocytic leukaemia.. Alex had been suffering fatigue, numerous headaches, her stomach had swollen and she noticed bruises appearing all over her body.. She had originally put her symptoms down to being a lazy teenager and didnt tell anyone because she was worried about making a fuss.. But thanks to the information in the film the academically-gifted teenager, who is aiming to study at Cambridge, finally realised she needed to see a specialist.. Alex, of Bredgar, Kent, went to see her GP in October 2010 and was diagnosed with chronic myeloid leukaemia ...
Arthrisoothe Gold Tablets- joint supplements for dogs with arthritis, joint pain and stiffness. This natural pain relief remedy contains glucosamine, chondroitin, MSM and more.
usr/bin/php ,?php # Run this script by providing it with the top path of AUR. # In that path you should see a file lib/aur.inc # # This will remove files which belong to deleted packages. # # ex: php cleanup dev/aur/web # $dir = $argv[1]; if (empty($dir)) { echo Please specify AUR directory.\n; exit; } set_include_path(get_include_path() . PATH_SEPARATOR . $dir/lib); include(config.inc); include(aur.inc); include(pkgfuncs.inc); exec(ls . INCOMING_DIR, $files); $count = 0; foreach ($files as $pkgname) { if (!package_exists($pkgname)) { echo Removing . INCOMING_DIR . $pkgname\n; system(rm -r . INCOMING_DIR . $pkgname); $count++; } } echo \nRemoved $count directories.\n ...
usr/bin/php ,?php # Run this script by providing it with the top path of AUR. # In that path you should see a file lib/aur.inc # # This will remove files which belong to deleted packages. # # ex: php cleanup dev/aur/web # $dir = $argv[1]; if (empty($dir)) { echo Please specify AUR directory.\n; exit; } set_include_path(get_include_path() . PATH_SEPARATOR . $dir/lib); include(config.inc); include(aur.inc); include(pkgfuncs.inc); exec(ls . INCOMING_DIR, $files); $count = 0; foreach ($files as $pkgname) { if (!package_exists($pkgname)) { echo Removing . INCOMING_DIR . $pkgname\n; system(rm -r . INCOMING_DIR . $pkgname); $count++; } } echo \nRemoved $count directories.\n ...
In this episode of Dialing for Doctors (aka, Tales of Telehell), we consider a growing subset of telehealth seekers connecting from their cars. This has happened several times and it always catches me surprise. While Ive had live televideo visits with patients walking the dog, waking up in bed, and from the waiting room of another doctors office, consults in cars is about the nuttiest. What is the patients role in telehealth? Read Post ...
Bratara din aur tennis cu diamante (BRCRD0017101). Material: Aur. Culoare aur: Alb. Tip piatra: Diamante negre. Vezi mai multe detalii pe site.
[QUOTE=pjarpi]loved your post...but if bhabho change...what will be left in DABH...she is the one who is making the stroy interesting for viewers...[/QUOTE] True indeed...but after a while the intense level of emotional attyachar becomes a bit overwhelming. Maybe the CVs can focus on developing ... | Page: 2 | 3403798 | Diya Aur Baati Hum Forum
In Gulabo Sitabo, Fatima Mahal is both, a character and the set it is the stage that carries, encases and showcases its cast of characters
Harta Romaniei, pesteri, manastiri, Ghid on-line pentru Romania. Va oferim idei de trasee turistice, informatii despre pesteri, manastiri, harta Romaniei in detaliu ...
Compounds containing metal ions can be used as medicine, such as lithium compounds and auranofin. Metal compounds and ions can ... Kean, W. F.; Hart, L.; Buchanan, W. W. (1997). "Auranofin". British Journal of Rheumatology. 36 (5): 560-572. doi:10.1093/ ...
Auranofin, a chelate complex of gold, is used in the treatment of rheumatoid arthritis, and penicillamine, which forms chelate ... Kean WF, Hart L, Buchanan WW (May 1997). "Auranofin". British Journal of Rheumatology. 36 (5): 560-72. doi:10.1093/rheumatology ...
Auranofin Shaw, III C. F. (1999). "Gold-Based Therapeutic Agents". Chemical Reviews. 99 (9): 2589-600. doi:10.1021/cr980431o. ... It was recently discontinued from the US market along with sodium aurothiomalate leaving only Auranofin as the only gold salt ... Only one gold drug remains in active clinical use for this purpose in the United States: auranofin although sodium ... In the United Kingdom, only sodium aurothiomalate and auranofin were used recently. In 2001, aurothioglucose was withdrawn from ...
Beck RK (2002). "Auranofin and Aurothioglucose side effects & overdose". Drug Reference for EMS Providers. pp. 164-165. " ... "Auranofin complete list of warnings, precautions and reactions". Drugs.com. "Aurothioglucose Suspension adverse effects". ... Auranofin (UK & US) Aurothioglucose (Gold thioglucose) (US) Disodium aurothiomalate Sodium aurothiosulfate (Gold sodium ...
Gold antiarthritic drugs, e.g. auranofin have been commercialized. Carbon monoxide-releasing molecules are metal complexes have ...
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
Along with an orally-administered gold salt, auranofin, it is one of only two gold compounds currently employed in modern ... Iqbal MS, Saeed M, Taqi SG (2008). "Erythrocyte membrane gold levels after treatment with auranofin and sodium aurothiomalate ... It was recently discontinued from the US market along with aurothioglucose leaving only auranofin as the only gold salt on the ... auranofin and penicillamine in the treatment of patients with rheumatoid arthritis". British Journal of Rheumatology. 37 (9): ...
Auranofin Aurothioglucose Gold salts Sodium aurothiomalate Shaw III CF (September 1999). "Gold-based therapeutic agents". ...
April 2015). "Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis". Proceedings of the ... such as auranofin or Ebselen.) This is especially true for Mycobacterium Haemophilum, and could be used for antibiotic ...
The compound is a common ligand in organometallic chemistry, such as in auranofin. It is a pyramidal molecule with approximate ...
In 2017 she demonstrated that taking Auranofin whilst on RAPTA-T enhances the activity of the anti-cancer drug. She teaches ...
... auranofin inhibits thioredoxin reductase, captopril inhibits angiotensin converting enzyme, celecoxib blocks cyclooxygenase-2, ... auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide. ...
It has also been shown to reduce both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin ... "Glutaredoxin 2 reduces both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin and 4- ...
QM01BA99 Combinations M01CA03 Oxycinchophen M01CB01 Sodium aurothiomalate M01CB02 Sodium aurothiosulfate M01CB03 Auranofin ...
Auranofin) 2-(1-Aziridinyl)ethanol Aziridyl benzoquinone Azobenzene 11H-Benz[bc]aceanthrylene Benz[l]aceanthrylene Benz[a] ...
... auranofin, acetaminophen, nimesulide, paraquat, ethoxyquin, diesel exhaust particles, silica, nanotubes, 15-deoxy-Δ12,14 ...
Atrosept Atrovent Attenuvax Augmentin Auralgan auranofin (INN) Aureomycin Aurexis (Inhibitex) Aurodex Aurolate ...
... platinum containing anticancer agents gold salts such as auranofin - anti-inflammatory for treatment of arthritis silver ...
Auranofin, Buthionine Sulfoximine and Suppressive Antiretroviral Therapy Induce Post-Therapy Control of Viremia in Chronically ...
Drug-screening reveals auranofin induces apoptosis in ovarian cancer cells in vitro. Auranofin may inhibit replication of SARS- ... Preliminary results show that auranofin contributed to a decrease in the viral reservoir. Auranofin has been identified in a ... Auranofin is a gold salt classified by the World Health Organization as an antirheumatic agent. It has the brand name Ridaura. ... Auranofin protected mice from an otherwise lethal infection with methicillin-resistant S. aureus (MRSA). The drug acts in a ...
Auranofin) 2-(1-Aziridinyl)ethanol Aziridyl benzoquinone Azobenzene 11H-Benz[bc]aceanthrylene Benz[l]aceanthrylene Benz[a] ...
gold salts (sodium aurothiomalate, auranofin) (seldom used today). unknown. csDMARD. hydroxychloroquine (anti-malarial). TNF- ...
... is a S-glycosyl compound (CHEBI:35275) auranofin (CHEBI:2922) is a gold coordination entity (CHEBI:33971 ... auranofin (CHEBI:2922) has role antirheumatic drug (CHEBI:35842) auranofin (CHEBI:2922) has role EC 1.8.1.9 (thioredoxin ... CHEBI:2922 - auranofin. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ... auranofin (CHEBI:2922) has role immunosuppressive agent (CHEBI:35705) ...
Drug-screening reveals auranofin induces apoptosis in ovarian cancer cells in vitro. Auranofin may inhibit replication of SARS- ... Preliminary results show that auranofin contributed to a decrease in the viral reservoir. Auranofin has been identified in a ... Auranofin is a gold salt classified by the World Health Organization as an antirheumatic agent. It has the brand name Ridaura. ... Auranofin protected mice from an otherwise lethal infection with methicillin-resistant S. aureus (MRSA). The drug acts in a ...
Auranofin: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking auranofin,. *tell your doctor and pharmacist if you are allergic to auranofin or any other drugs. ... If you become pregnant while taking auranofin, call your doctor. You should not try to become pregnant while taking auranofin ... Auranofin may cause an upset stomach. Take auranofin after meals or a light snack. ...
Professional guide for Auranofin. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions ... Auranofin contains gold and, like other gold-containing drugs, can cause gold toxicity, signs of which include: Fall in ... Like other gold preparations, auranofin is only indicated for use in selected patients with active rheumatoid arthritis. ... The results of recommended laboratory work should be reviewed before writing each auranofin prescription. In addition, the ...
Auranofin is an FDA-approved gold salt compound that is used to control inflammation and is already known to inhibit the ... Tags: Arthritis, Auranofin, Bacteria, Blood, C. Diff, chemical reaction, Clostridium Difficile, Compound, Diarrhea, Fluoride, ... The key discovery occurred when the team found that the gold drug Auranofin, used to treat arthritis, impacted seleniums ...
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically ...
... could have a major impact on an ovarian cancer cells sensitivity to treatment using the anti-rheumatic drug auranofin, ... Auranofin is currently undergoing trials for repurposing to treat recurrent epithelial ovarian cancer, which makes up around 90 ... It showed that IGROV1 cells exhibited a more fluidised membrane compared to OVCAR5, were more sensitive to auranofin induced ... Membrane fluidity influences sensitivity of ovarian cancer cell lines to auranofin. University of Plymouth ...
Auranofin is an oral gold compound used for the treatment of rheumatoid arthritis (RA). The use of auranofin has declined in ... Auranofin for the treatment of rheumatoid arthritis. The objective of this review was to evaluate the short-term efficacy of ... Auranofin may be most appropriate for those patients with early and mild disease who are more likely to respond to less potent ... Auranofin appears to have a small clinically and statistically significant benefit on the disease activity of patients with RA ...
... could have a major impact on an ovarian cancer cells sensitivity to treatment using the anti-rheumatic drug auranofin, ... Auranofin is currently undergoing trials for repurposing to treat recurrent epithelial ovarian cancer, which makes up around 90 ... New research has shown that increased fluidity within the cell membrane can enhance the ability of auranofin to induce ... It showed that IGROV1 cells exhibited a more fluidised membrane compared to OVCAR5, were more sensitive to auranofin induced ...
AURANOFIN (au RANE oh fin) is a gold compound. It is used to treat rheumatoid arthritis when other medicines have not worked. ... Generic Name: auranofin. It is used to treat rheumatoid arthritis when other medicines have not worked ... an unusual or allergic reaction to auranofin, gold compounds, other medicines, foods, dyes, or preservatives ...
Auranofin: A New Drug for Rheumatoid Arthritis HERBERT R. DYER, M.D. ... Abruzzos (1) editorial on auranofin oral gold is most interesting. The implication that nonrheumatologists regularly treat, ... Auranofin: A New Drug for Rheumatoid Arthritis. Ann Intern Med. 1987;106:631-632. doi: https://doi.org/10.7326/0003-4819-106-4- ...
Auranofin treatment in early rheumatoid arthritis may postpone early retirement. Results from a 2-year double blind trial.. ...
The Kinetics and Mechanism of the Reaction Between Serum Albumin and Auranofin (and its Isopropyl Analogue) In Vitro. ...
Ament on auranofin medication: Medication headache....a type of frequent or daily headache. Im not positive though. Need to ... Auranofin (Definition) Auranofin is an arthritis therapy which is a kind of pain medication. ...Read more ...
... What is this medicine?. AURANOFIN (au RANE oh fin) is a gold compound. It is used to treat rheumatoid ... an unusual or allergic reaction to auranofin, gold compounds, other medicines, foods, dyes, or preservatives ...
The primary purpose of this study is to find out what effects (good or bad) the drugs auranofin and sirolimus have on patients ... PKCι & mTOR Inhibition With Auranofin+Sirolimus for Squamous Cell Lung Cancer. * Print details ... with lung cancer; to find out if auranofin and sirolimus can stop or slow the growth of the lung cancer; to learn more about ...
Auranofin) drug information & product resources from MPR including dosage information, educational materials, & patient ...
Experimental: Treatment (auranofin) Patients receive auranofin PO BID on days 1-28. Courses repeat every 28 days in the absence ... Auranofin in Treating Patients With Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer. The safety and ... Patients receive auranofin orally (PO) twice daily (BID) on days 1-28. Courses repeat every 28 days in the absence of disease ... Drug Information available for: Auranofin Genetic and Rare Diseases Information Center resources: Ovarian Cancer Fallopian Tube ...
Effect of auranofin treatment on aberrant splenic interleukin production in adjuvant arthritic rats.. J C Lee, M J Dimartino, B ... In contrast, auranofin administered to normal rats, in the same dosing regimen, did not affect interleukin production. ... Therapeutic administration of auranofin to AA rats with established disease resulted in normalization of IL-1 production ... Prophylactic treatment of AA rats with auranofin resulted in a slight reduction in paw edema, a complete normalization of the ...
Auranofin had no inhibitory effect on the activity of the catalytic domain of constitutively active PMT in vitro, demonstrating ... The amount of endogenous substrate levels modified by PMT in cells pretreated with auranofin was reduced compared to cells ... This was demonstrated by the strong inhibitory effect of the pharmacological TrxR inhibitor auranofin, which inhibited the ... and that the drug auranofin can serve as an efficient inhibitor, which might be a starting point for novel therapeutic options ...
Experimental: Treatment (auranofin and sirolimus) Patients receive auranofin PO on days 1-28 and sirolimus PO on days 1-28 ( ... Sirolimus and Auranofin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer or Small Cell Lung Cancer. ... Drug: Auranofin Drug: Sirolimus Other: Laboratory Biomarker Analysis Other: Pharmacological Study Phase 1 Phase 2 ... MTD of auranofin (Phase I) [ Time Frame: 28 days ]. The number and severity of all adverse events (overall and by dose level) ...
Auranofin induced a sustained increase of [Ca2+]i in a concentration and time dependent manner. The use of different blockers ... We investigate the effects of Auranofin in inducing cell death by apoptosis and whether these changes are correlated to changes ... Auranofin, a transition metal complex is used for the treatment of rheumatoid arthritis but is also an effective anti-cancer ... of calcium channels did not reveal the source for the rise of [Ca2+]i. Overall, elevation of [Ca2+]i by Auranofin might be ...
Auranofin or D-Penicillamine in the Treatment of Rheumatoid Arthritis MARC C. HOCHBERG, M.D., M.P.H. ... Auranofin: A New Drug for Rheumatoid Arthritis Annals of Internal Medicine; 105 (2): 274-276 ... Auranofin or D-Penicillamine in the Treatment of Rheumatoid Arthritis. Ann Intern Med. ;105:528-535. doi: 10.7326/0003-4819-105 ... Ninety patients were entered into a randomized, controlled, double-blind trial lasting 12 months to compare auranofin (6 mg/d ...
Auranofin for Chronic Lymphocytic Leukemia. Approximately 15,000 people in the United States are diagnosed each year with a ... Auranofin was previously approved by the Food and Drug Administration (FDA) as a treatment for rheumatoid arthritis. The goals ... The arthritis drug auranofin was identified as a potent, selective cytotoxic agent. A cooperative research and development ... The IND was cleared by the FDA, and auranofin underwent Phase I-IIa clinical trials in patients at three sites (NIH, the ...
Get up-to-date information on Auranofin side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about ... Auranofin is a gold-containing compound. The exact mechanism of auranofin is not understood, but it relieves symptoms of ... "RIDAURA (auranofin) capsule," DailyMed: Current Medication Information; U.S. National Library of Medicine. "Auranofin," Medline ... Serious side effects have been reported with auranofin. See the "Auranofin Precautions" section. ...
Auranofin Illinois EPA list. Keith list. Colborn list. Benbrook list. Danish Inert list. EU list. Not Listed. Not Listed. Not ... Auranofin WHO Acute Hazard. TRI Acute Hazard. Material Safety Data Sheets. Acute rating from U.S. EPA product label. U.S. NTP ... Auranofin IARC Carcinogens. U.S. NTP Carcinogens. California Prop 65 Known Carcinogens. U.S. EPA Carcinogens. TRI Carcinogen. ... Auranofin CA Prop 65 Developmental Toxin. U.S. TRI Developmental Toxin. CA Prop 65 Female Reproductive Toxin. CA Prop 65 Male ...
Auranofin causes loss of viability of CD19+B-CLL cells. Our findings in Fig. 1A demonstrate that exposure to auranofin for 24 ... Auranofin perturbs biologic networks of genes in CLL cells. We also determined the effects of auranofin treatment on gene ... Auranofin-induced ROS increases ER stress, which contributes to auranofin lethality in CLL cells. Increased ROS levels and ... cell viability values significantly less in ZAP70+ auranofin-treated cells than ZAP70− auranofin-treated cells (P , 0.05). D, ...
Auranofin (AF) (Ridaura®) is approved for use in treating rheumatoid arthritis but it exhibited preclinical efficacy in CLL ... Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic ... Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic ... Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic ...
Auranofin appears to inhibit the growth and initiate apoptosis in canine lymphoma cells in vitro at clinically achievable ... The orally available gold complex auranofin (AF) has been used in humans, primarily as an antirheumatic/immunomodulatory agent ... Auranofin: repurposing an old drug for a golden new age. Drugs R D. 2015;15:13-20.View ArticlePubMedPubMed CentralGoogle ... Auranofin is an agent that has approved by the US FDA for decades for the treatment of rheumatoid arthritis in humans, and has ...
Auranofin blocks the uptake of selenium and results in the accumulation of the auranofin-selenide adduct in the culture medium ... Auranofin disrupts selenium metabolism in Clostridium difficile by forming a stable Au-Se adduct J Biol Inorg Chem. 2009 May;14 ... Auranofin potently inhibits the growth of C. difficile but does not similarly affect other clostridia that do not utilize ... Moreover, auranofin inhibits the incorporation of radioisotope selenium ((75)Se) in selenoproteins in both Escherichia coli, ...
  • Auranofin (AF) (Ridaura®) is approved for use in treating rheumatoid arthritis but it exhibited preclinical efficacy in CLL cells. (aacrjournals.org)
  • The oral gold compound 2,3,4,6-tetra-o-acetyl-1-thio-β-D-glucopyrano- sato-S-(triethyl-phosphine) gold, manufactured under the drug name auranofin (AF, Ridaura®), was developed in the 1980s as a potential antirheumatic agent. (biomedcentral.com)
  • Auranofin (ridaura) contains a medical form of gold and fights rheumatoid arthritis by reducing inflammation. (onlymedics.com)
  • What is Ridaura (Auranofin) prescribed for? (mydrugcenter.com)
  • RIDAURA® Pharmascience Auranofin Antirheumatic Agent Action And Clinical Pharmacology: Auranofin is a gold preparation and therefore has the potential for serious gold toxicity. (rxmed.com)
  • Ridaura contains auranofin, a synthetic gold compound. (nps.org.au)
  • Auranofin is used to treat rheumatoid arthritis. (wikipedia.org)
  • Auranofin is used, with rest and nondrug therapy, to treat rheumatoid arthritis. (medlineplus.gov)
  • Like other gold preparations, auranofin is only indicated for use in selected patients with active rheumatoid arthritis. (drugs.com)
  • Auranofin is an oral gold compound used for the treatment of rheumatoid arthritis (RA). (cochrane.org)
  • Suarez-Almazor ME, Spooner C, Belseck E, Shea B. Auranofin versus placebo in rheumatoid arthritis. (cochrane.org)
  • Auranofin treatment in early rheumatoid arthritis may postpone early retirement. (nih.gov)
  • Auranofin, a transition metal complex is used for the treatment of rheumatoid arthritis but is also an effective anti-cancer drug. (mdpi.com)
  • Ninety patients were entered into a randomized, controlled, double-blind trial lasting 12 months to compare auranofin (6 mg/d), and D-penicillamine (250 mg/d for 4 weeks, 500 mg/d for 4 weeks, then 750 mg/d thereafter) in the treatment of rheumatoid arthritis. (annals.org)
  • These results suggest that in the dosage regimen used, auranofin is safer than D-penicillamine but that D-penicillamine tends to show greater clinical effectiveness in patients with rheumatoid arthritis. (annals.org)
  • Auranofin was previously approved by the Food and Drug Administration (FDA) as a treatment for rheumatoid arthritis. (nih.gov)
  • Auranofin treats rheumatoid arthritis. (rxwiki.com)
  • Auranofin is a prescription medication used to treat symptoms of rheumatoid arthritis. (rxwiki.com)
  • The exact mechanism of auranofin is not understood, but it relieves symptoms of rheumatoid arthritis including painful, swollen, and tender joints. (rxwiki.com)
  • Auranofin is a prescription medication used to treat symptoms of rheumatoid arthritis, including including painful, swollen, and tender joints and morning stiffness. (rxwiki.com)
  • This screen identified auranofin, a US Food and Drug Administration (FDA)-approved drug used therapeutically for rheumatoid arthritis, as a sensitizer of cisplatin. (springer.com)
  • Auranofin, an oral anti-rheumatic drug, has been used for many years in the treatment of rheumatoid arthritis (RA). (up.ac.za)
  • Auranofin is a drug that is approved for the treatment of rheumatoid arthritis but is being investigated for potential therapeutic application in a number of other diseases including cancer, neurodegenerative disorders. (medchemexpress.com)
  • Auranofin has been prescribed to patients with rheumatoid arthritis since 1985. (onlymedics.com)
  • The gold compound auranofin, long used for rheumatoid arthritis, might turn out to be the best treatment yet for amoebic dysentery. (expressmeds-canada.com)
  • Auranofin is an antirheumatic agent, prescribed for rheumatoid arthritis. (medindia.net)
  • The aim of the present study is to investigate the in vivo efficacy of auranofin (rheumatoid arthritis FDA-approved drug) in a CDI mouse model and establish an adequate dosage for treatment. (vt.edu)
  • We found one drug, auranofin, an oral gold-containing compound approved by the FDA in 1985 to treat rheumatoid arthritis, had an IC50 significantly lower for Entamoeba and equivalent for Giardia to metronidazole. (grantome.com)
  • A drug called auranofin, approved for the treatment of rheumatoid arthritis, effectively inhibits severe acute respiratory syndrome coronavirus (SARS-CoV-2) in laboratory conditions, as described in a new study by Georgia State University researchers. (news-medical.net)
  • Drug-screening reveals auranofin induces apoptosis in ovarian cancer cells in vitro. (wikipedia.org)
  • We investigate the effects of Auranofin in inducing cell death by apoptosis and whether these changes are correlated to changes of intracellular calcium concentration ([Ca 2+ ] i ) in breast cancer cells (MCF-7). (mdpi.com)
  • Auranofin appears to inhibit the growth and initiate apoptosis in canine lymphoma cells in vitro at clinically achievable concentrations. (biomedcentral.com)
  • Further study validated that auranofin synergistically enhanced the anti-tumor activity of cisplatin in chemo-resistant SCLC cells, which was accompanied by the enhanced induction of cell cycle arrest and apoptosis. (springer.com)
  • Auranofin induces apoptosis in cells through a Bax/Bak-dependent mechanism associated with selective disruption of mitochondrial redox homeostasis in conjunction with oxidation of Prx3 [1] . (medchemexpress.com)
  • Auranofin treatment activates the pro-apoptotic caspase-3, increases protein levels of apoptosis-inducing proteins Bax and Bim and reduces the expression of the anti-apoptotic mediator Bcl-2 in SKOV3 cells [2] . (medchemexpress.com)
  • Auranofin inhibits the cell growth and induction of mitochondrial apoptosis in PC3 human prostate cancer cells. (medchemexpress.com)
  • The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. (medchemexpress.com)
  • Auranofin promotes mitochondrial apoptosis by inducing annexin A5 expression and translocation in human prostate cancer cells. (medchemexpress.com)
  • In conclusion, our data demonstrated that combined treatment with R428 and auranofin synergistically induced apoptosis in human breast cancer cells and may thus serve as a novel and valuable approach for cancer therapy. (biomolther.org)
  • Previous report showed that auranofin induced apoptosis by enhancement of annexin A5 expression in PC-3 cells . (bvsalud.org)
  • To understand the role of annexin A5 in auranofin -mediated apoptosis , we performed microarray data analysis to study annexin A5 -controlled gene expression in annexin A5 knockdown PC-3 cells . (bvsalud.org)
  • Treatment with auranofin decreased PAI-2 and increased annexin A5 expression as well as promoting apoptosis . (bvsalud.org)
  • Furthermore, auranofin -induced apoptosis was recovered by annexin A5 siRNA but it was promoted by PAI-2 siRNA . (bvsalud.org)
  • Taken together, our study suggests that induction of annexin A5 by auranofin may enhance apoptosis through suppression of PAI-2 expression in PC-3 cells . (bvsalud.org)
  • Auranofin had no inhibitory effect on the activity of the catalytic domain of constitutively active PMT in vitro, demonstrating that auranofin did not directly inhibit PMT activity, but interferes with the mode of action of PMT in cells. (mdpi.com)
  • In this work we have identified, using mass spectrometry, a stable complex formed upon reaction of auranofin (a gold-containing drug) with selenide in vitro. (nih.gov)
  • Most importantly, oral auranofin was effective in vitro and in vivo against E. histolytica and both metronidazole-sensitive and resistan strains of Giardia. (grantome.com)
  • In addition, auranofin may prove to be a future broad spectrum antiparasitic drug as in vitro efficacy has also been demonstrated against Cryptosporidium, Trichomonas, toxoplasmosis, T. brucei, filariasis, and schistosomiasis. (grantome.com)
  • We tested the impact of the gold compound, auranofin, on phenotype and viability of CD4 + T cells in vitro, and on persistence of lentiviral reservoir cells in vivo. (elsevier.com)
  • Auranofin potently inhibits the growth of C. difficile but does not similarly affect other clostridia that do not utilize selenoproteins to obtain energy. (nih.gov)
  • Moreover, auranofin inhibits the incorporation of radioisotope selenium ((75)Se) in selenoproteins in both Escherichia coli, the prokaryotic model for selenoprotein synthesis, and C. difficile without impacting total protein synthesis. (nih.gov)
  • On the basis of these results, we propose that formation of this complex and the subsequent deficiency in available selenium for selenoprotein synthesis is the mechanism by which auranofin inhibits C. difficile growth. (nih.gov)
  • Auranofin inhibits proliferation and survival of SKOV3 cells in a dose- and time-dependent manner. (medchemexpress.com)
  • Treatment with auranofin significantly inhibits cell viability with an IC 50 value of 2.5 μM after 24 h [3] . (medchemexpress.com)
  • Increased fluidity in cell membranes could have a major impact on an ovarian cancer cell's sensitivity to treatment using the anti-rheumatic drug auranofin, research led by Plymouth University suggests. (eurekalert.org)
  • Auranofin (SKF-39162) is a thioredoxin reductase ( TrxR ) inhibitor with an IC 50 of 0.2 μM. (medchemexpress.com)
  • Auranofin has the capacity to selectively inhibit endogenous antioxidant enzymes thioredoxin reductase (TrxR) and glutathione peroxidase (GPx), resulting in oxidative stress and the initiation of a pro-apoptotic cascade. (edu.au)
  • In this study we investigated the altered production of interleukins in arthritic rats and evaluated the effects of auranofin treatment on disease progression and aberrant interleukin production. (jimmunol.org)
  • Over the past decades, studies have demonstrated the anti-proliferative activity of Auranofin at very low concentrations [ 6 , 7 ]. (mdpi.com)
  • The effects of increased C. difficile inoculum, and pre-exposure to simulated gastric intestinal fluid (SGF) and simulated intestinal fluid (SIF), on the antibacterial activity of auranofin were investigated. (vt.edu)
  • Significantly, the anti-leishmanial activity of auranofin transferred to cell-based amastigote assays as well as in vivo murine models. (uportu.pt)
  • This was demonstrated by the strong inhibitory effect of the pharmacological TrxR inhibitor auranofin, which inhibited the intoxication of target cells with PMT, as determined by analyzing the PMT-catalyzed deamidation of GTP-binding proteins (G-proteins) in the cytosol of cells. (mdpi.com)
  • The well-characterized TrxR inhibitor auranofin, which is FDA-approved and currently in clinical trials against leukemia and a number of solid cancers, displayed effects comparable with MJ25 on cells and led to eradication of cultured melanoma cells at low micromolar concentrations. (oncotarget.com)
  • AURANOFIN (au RANE oh fin) is a gold compound. (aarp.org)
  • Preliminary results show that auranofin contributed to a decrease in the viral reservoir. (wikipedia.org)
  • Our results show that auranofin appears to be efficacious in the short-term treatment of patients with RA (6 months), and has a small but clinically and statistically significant benefit on the disease activity of these patients. (cochrane.org)
  • Auranofin is also used sometimes for psoriatic arthritis. (medlineplus.gov)
  • The key discovery occurred when the team found that the gold drug Auranofin, used to treat arthritis, impacted selenium's metabolism process. (news-medical.net)
  • The arthritis drug auranofin was identified as a potent, selective cytotoxic agent. (nih.gov)
  • In addition, whereas traditional chemotherapy can be quite toxic, auranofin has received previous regulatory approval and was demonstrated to be reasonably safe and effective in the treatment of arthritis. (nih.gov)
  • Auranofin, a cheap drug, which is already prescribed for arthritis, could fight amoebic dysentery, according to researchers in the US. (bellenews.com)
  • Auranofin, a common and cheap drug currently used for arthritis, could help fight against parasitic organisms responsible for amoebic dysentery, according to US researchers. (onlymedics.com)
  • An inexpensive arthritis drug called auranofin has been shown in lab and animal tests to kill the parasites that cause amoebic dysentery and giardiasis, and human trials are expected to start soon. (expressmeds-canada.com)
  • Researchers in California found that auranofin, an oral therapy for arthritis that has been around since 1985, is highly effective against the parasite Entamoeba histolytica. (expressmeds-canada.com)
  • After developing a new rapid drug screening technique, the scientists discovered that a gold-containing drug called auranofin may be effective in treating amebiasis. (expressmeds-canada.com)
  • Patients receive auranofin orally (PO) twice daily (BID) on days 1-28. (clinicaltrials.gov)
  • Patients receive auranofin orally (PO) on days 1-28 and sirolimus PO on days 1-28 (days 8-28 of course 1). (clinicaltrials.gov)
  • Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53. (medchemexpress.com)
  • Auranofin-mediated inhibition of STAT3 phosphorylation was recovered by pretreatment with antioxidants containing thiol groups. (nih.gov)
  • Auranofin exposure resulted in a concentration dependent differential inhibition of selenoprotein antioxidants. (edu.au)
  • Significant inhibition of TrxR was observed at 20nM Auranofin with inhibition of GPx from 10µM. (edu.au)
  • Significant increases in reactive oxygen species (ROS) were associated with antioxidant inhibition at Auranofin concentrations of 100nM (TrxR inhibition) and 10µM (TrxR and GPx inhibition), respectively. (edu.au)
  • Here, we examined the cell growth inhibition mediated by R428 and auranofin individually as well as in combination in the human breast cancer cell lines MCF-7 and MDAMB- 231 to identify new advanced combination treatments for human breast cancer. (biomolther.org)
  • Substitution of Cys-179 of IKK beta with alanine (C179A) rendered the enzyme to become resistant to inhibition by a gold compound auranofin , however, similar protective effect was not observed with an equivalent level of IKK alpha (C178A) mutant expressed in the cells . (bvsalud.org)
  • The different inhibitory effect of auranofin on IKK alpha (C178A) and IKK beta (C179A) mutants indicates that gold could inhibit the two subunits of IKK in a different mode, and the inhibition of NF- kB and IKK activation induced by inflammatory signals in gold -treated cells appears through its interaction with Cys-179 of IKK beta . (bvsalud.org)
  • SmTGR, an essential enzyme of the S. mansoni ROS detoxification machinery, is known to be inhibited by Auranofin although the inhibition mechanism has not been completely clarified. (edu.sa)
  • Effect of auranofin treatment on aberrant splenic interleukin production in adjuvant arthritic rats. (jimmunol.org)
  • The effect of Auranofin exposure on TrxR and GPx, and the potential for cellular protection through selenium supplementation was examined in the non-cancerous human cell line Swan-71. (edu.au)
  • The pro-differentiating effect of auranofin was investigated in human primary CD4 + T cells, and its capacity to deplete the viral DNA (vDNA) reservoir was tested in a pilot study involving six SIVmac251-infected macaques with viral loads stably suppressed by antiretroviral therapy (ART) (tenofovir/emtricitabine/raltegravir). (elsevier.com)
  • Addition of selenium in the form of selenite or L-selenocysteine to the growth medium significantly reduces the inhibitory action of auranofin on the growth of C. difficile. (nih.gov)
  • The synergistic action of auranofin and cisplatin was through ROS overproduction, thereby leading to mitochondrial dysfunction and DNA damage. (springer.com)
  • In conclusion, the results show that TrxR is crucial for the mode of action of PMT in mammalian cells, and that the drug auranofin can serve as an efficient inhibitor, which might be a starting point for novel therapeutic options against toxin-associated diseases. (mdpi.com)
  • Physicians planning to use auranofin should be experienced with chrysotherapy and should thoroughly familiarize themselves with the toxicity and benefits of auranofin. (drugs.com)
  • Much of the problems related to the toxicity related to auranofin are due to its lipophilicity. (up.ac.za)
  • All compounds including auranofin were tested against normal cells to determine its toxicity as well as its anti-inflammatory activity. (up.ac.za)
  • Three novel auranofin derivatives were compared to auranofin with regards to lipophilicity, toxicity and anti-inflammatory properties The lipophilicity of the three compounds were compared to auranofin using the octanol-water partition coefficient method. (up.ac.za)
  • All three novel compounds proved less toxicity at comparable concentrations in primary porcine hepatocytes and in fibroblast proliferation, Asa-fin and Mpta-fin proved less toxic than Auranofin. (up.ac.za)
  • The full study - Linking genotoxicity and cytotoxicity with membrane fluidity: a comparative study in ovarian cancer cell lines following exposure to auranofin by Oommen, Dodd, Yiannakis, Moyeed and Jha - is published in Mutation Research - Genetic Toxicology and Environmental Mutagenesis, doi 10.1016/j.mrgentox.2016.09.003. (plymouth.ac.uk)
  • The cytotoxicity of these novel gold compounds Asa-fin, Mpta-fin and Pta-fin were compared to auranofin using primary porcine hepatocytes and chicken embryo fibroblasts cultures. (up.ac.za)
  • It showed that IGROV1 cells exhibited a more fluidised membrane compared to OVCAR5, were more sensitive to auranofin induced cytotoxicity and exhibited an increased number of DNA double strand breaks upon auranofin treatment. (eurekalert.org)
  • Cytotoxicity of Auranofin was evaluated using MTS assay and the Trypan blue dye exclusion method. (mdpi.com)
  • This is not a complete list of auranofin drug interactions. (rxwiki.com)
  • Auranofin may inhibit replication of SARS-CoV-2, the virus responsible for causing COVID-19 in cell culture. (wikipedia.org)
  • Auranofin is an FDA-approved gold salt compound that is used to control inflammation and is already known to inhibit the activity of certain selenoproteins. (news-medical.net)
  • Auranofin is a safer treatment compared to the more common injectable gold thiolates (gold sodium thiomalate and gold thioglucose), but meta-analysis of 66 clinical trials concluded that it is somewhat less effective. (wikipedia.org)
  • Auranofin is under investigation as a means of reducing the viral reservoir of HIV that lies latent in the body's T-cells despite treatment with antiretroviral therapy. (wikipedia.org)
  • Immunosuppressive therapy, such as auranofin, may be an effective treatment for epithelial ovarian, primary peritoneal, or fallopian tube cancer. (clinicaltrials.gov)
  • Prophylactic treatment of AA rats with auranofin resulted in a slight reduction in paw edema, a complete normalization of the depressed IL-2 production, and a reduction of the elevated IL-1 production, but had no effect on the depressed IL-3 production. (jimmunol.org)
  • This phase I/II trial studies the side effects and best dose of auranofin when given together with sirolimus and to see how well it works in treating patients with lung cancer that has spread or other places in the body and cannot be cured or controlled by treatment or has come back after a period of time during which the cancer could not be detected. (clinicaltrials.gov)
  • I. To establish the maximum tolerated dose of auranofin plus sirolimus after at least one line of platinum based chemotherapy for lung cancer (squamous, ras-mutated adenocarcinoma, or small cell lung cancer) patients with no acceptable standard treatment options. (clinicaltrials.gov)
  • The goals of this TRND project are to develop auranofin as a treatment for refractory CLL and to develop a novel collaborative paradigm that is broadly applicable to repurposing drugs for rare diseases. (nih.gov)
  • Furthermore, in vivo study demonstrated that the combination treatment of auranofin and cisplatin dramatically inhibited tumor growth in SCLC. (springer.com)
  • It showed that auranofin was much better than the current treatment, metronidazole, at killing Entamoeba histolytica. (bellenews.com)
  • Although auranofin has to date only been tested in animal models of amoebic disease, this means that there is now a potential alternative treatment for individual cases where metronidazole fails to cure the infection or in the event resistance to metronidazole emerge as a clinical problem in the future. (bellenews.com)
  • Treatment of neutrophils with auranofin and the three compounds showed that auranofin, Asa-fin and Mpta-fin had a biphasic activity on hydrogen peroxide production with higher concentrations decreasing hydrogen peroxide production, possibly leading to the anti-inflammatory action of these drugs. (up.ac.za)
  • Treatment of neutrophils with auranofin and the three experimental compounds showed a decrease in CR3 expression on resting and stimulated neutrophils, however the effect was more marked in stimulated neutrophils. (up.ac.za)
  • Studies on animals demonstrated that Auranofin was 10 times more effective than the existing treatment, metronidazole, at killing Entamoeba histolytica. (onlymedics.com)
  • Based on these findings, we will test the hypothesis that oral auranofin is effective treatment of amebiasis and giardiasis. (grantome.com)
  • Our proposed clinical trial is a Phase IIa, 2 parallel arms, randomized, controlled, double blinded, superiority treatment study comparing short course auranofin (5 days for Giardia and 7 days for Entamoeba) to placebo for treatment of amebiasis and giardiasis in adults. (grantome.com)
  • A proof-of-concept clinical trial assessing the safety of the coordinated undermining of survival paths by 9 repurposed drugs (aprepitant, auranofin, captopril, celecoxib, disulfiram, itraconazole, minocycline, ritonavir and sertraline) combined with metronomic temozolomide (CUSP9v3 treatment protocol) for recurrent glioblastoma. (clinicaltrials.gov)
  • Auranofin treatment at concentrations of 10μM and higher concentrations resulted in a ∼68% decrease in cellular viability and was associated with elevations in pro-apoptotic markers cytochrome c flux control factor (FCFc) at concentration of 100nM and mitochondrial Bax at 10μM. (edu.au)
  • Auranofin has been developed as antirheumatic drugs , which is currently under clinical development for the treatment of chronic lymphocytic leukemia . (bvsalud.org)
  • Auranofin is usually given when other medications have been tried without successful treatment of symptoms. (everydayhealth.com)
  • In the pilot study in vivo, auranofin transiently decreased the cell-associated vDNA reservoir in peripheral blood. (elsevier.com)
  • Auranofin has been identified in a high-throughput drug screen as 10 times more potent than metronidazole against Entamoeba histolytica, the protozoan agent of human amebiasis. (wikipedia.org)
  • In a cell-based screen, auranofin showed potent activity against replicating and non-replicating M. tuberculosis as well as other gram-positive bacteria. (wikipedia.org)
  • Auranofin may be most appropriate for those patients with early and mild disease who are more likely to respond to less potent (and less toxic) therapies. (cochrane.org)
  • In our studies in animal models, auranofin was ten times more potent against this parasite than metronidazole. (expressmeds-canada.com)
  • We identified the Food and Drug Administration-approved drug auranofin, a known inhibitor of Leishmania promastigote growth, as a potent cytotoxic anti-leishmanial agent and inducer of apoptotic-like death in promastigotes. (uportu.pt)
  • Seleem said that through his research and studies he has identified two drugs, auranofin and ebselen, as a potent antimicrobial agent that is capable of killing intracellular Methicillin-resistant Staphylococcus aureus (MRSA), a bacterium responsible for several difficult-to-treat infections in humans. (purdue.edu)
  • tell your doctor and pharmacist if you are allergic to auranofin or any other drugs. (medlineplus.gov)
  • Here, we used computational and docking techniques to investigate the molecular mechanism of interaction between SmTGR and Auranofin. (edu.sa)
  • OUTLINE: This is a phase I, dose-escalation study of auranofin followed by a phase II study. (clinicaltrials.gov)
  • Cells are treated with auranofin (0, 50, 100, 200 and 400 nM) for 72 h for the dose-dependent response assay and 100 nM of auranofin is added into the wells for 0, 24, 72 and 120 h for the time-dependent response assay. (medchemexpress.com)
  • High-field proton NMR spectroscopic analysis of urine and plasma has been employed to study the biochemical effects and nephrotoxic action of an intramuscular dose of auranofin in rats. (kingston.ac.uk)
  • The orally available gold complex auranofin (AF) has been used in humans, primarily as an antirheumatic/immunomodulatory agent. (biomedcentral.com)
  • Auranofin is a lipophilic gold compound with anti-inflammatory and immunosuppressive properties. (medchemexpress.com)
  • Auranofin appears to have a small clinically and statistically significant benefit on the disease activity of patients with RA. (cochrane.org)
  • This pilot clinical trial studies auranofin in treating patients with epithelial ovarian, primary peritoneal, or fallopian tube cancer. (clinicaltrials.gov)
  • The IND was cleared by the FDA, and auranofin underwent Phase I-IIa clinical trials in patients at three sites (NIH, the University of Kansas and Ohio State University). (nih.gov)
  • Therefore, our study provides a rational basis for further clinical study to test whether auranofin could enhance the sensitivity of cisplatin-based therapy in SCLC patients. (springer.com)
  • Because initial studies show auranofin is also active against cysts, we will follow the proportion of patients with sustained cure at 28 days and determine relapse or re-infection by genotyping of strains. (grantome.com)
  • Now new research, published in Mutation Research - Genetic Toxicology and Environmental Mutagenesis , has shown that increased fluidity within the cell membrane can enhance the ability of auranofin to induce increased DNA damage and cellular oxidation in these cells. (eurekalert.org)
  • Previous research has shown that chemo-resistant cancer cells demonstrate greater rigidity of the cell membrane, with the current study suggesting that greater uptake of auranofin could be influenced by increased membrane fluidity. (eurekalert.org)
  • The amount of endogenous substrate levels modified by PMT in cells pretreated with auranofin was reduced compared to cells treated with PMT alone. (mdpi.com)
  • Working with the NCATS Chemical Genomics Center, the lead investigator found that the drug auranofin selectively kills CLL cells. (nih.gov)
  • PCK1-KO hepatoma cells are treated with Auranofin, Sorafenib or Auranofin+Sorafenib as and the proteins are isolated and analyzed by western blotting. (medchemexpress.com)
  • Isobologram analyses of these cells indicated a clear synergism between R428 and auranofin with a combination index value of 0.73. (biomolther.org)
  • Results: In naïve, central memory and transitional memory CD4 + T cells, auranofin induced both phenotype changes and cell death which were more pronounced in the memory compartment. (elsevier.com)
  • Auranofin can lower blood cells that help your body fight infections. (everydayhealth.com)
  • Auranofin is currently undergoing trials for repurposing to treat recurrent epithelial ovarian cancer, which makes up around 90 per cent of diagnosed ovarian cancers. (eurekalert.org)
  • Therapeutic administration of auranofin to AA rats with established disease resulted in normalization of IL-1 production without affecting the suppressed IL-2 and IL-3 levels. (jimmunol.org)
  • The development strategy for repurposing the therapeutic use of auranofin for CLL capitalizes on available preclinical and clinical experience with a known, previously approved, therapeutic drug to accelerate clinical testing of the same drug for a new medical indication (CLL). (nih.gov)
  • Auranofin-mediated elevations in the plasma and urine concentrations of 3-D-hydroxybutyrate indicated an increased utilisation of fats for fuel in rats treated with this novel therapeutic agent. (kingston.ac.uk)
  • Standing in the field: Auranofin seems to be a recognised potential therapeutic drug in the field, as its application has already been investigated in many other diseases (including cancer, neurodegenerative disorders, HIV/AIDS, parasitic, bacterial and viral infections). (ox.ac.uk)
  • Auranofin is a gold salt classified by the World Health Organization as an antirheumatic agent. (wikipedia.org)
  • In contrast, auranofin administered to normal rats, in the same dosing regimen, did not affect interleukin production. (jimmunol.org)
  • In addition, ethanol was detectable in both urine and plasma obtained from auranofin-treated rats. (kingston.ac.uk)
  • Auranofin and Asa-fin decreased hydrogen peroxide and superoxide production. (up.ac.za)
  • Because auranofin has already been approved for use in humans, we can save years of expensive development. (bellenews.com)
  • The work presented in this paper is particularly useful as it identifies an existing drug, auranofin, that has already been tested and approved for use in humans, which seems to be at least as effective as metronidazole. (bellenews.com)
  • Auranofin blocks the uptake of selenium and results in the accumulation of the auranofin-selenide adduct in the culture medium. (nih.gov)
  • Auranofin induced a characteristic profile of proximal tubular damage as evidenced by aminoaciduria, lactic aciduria and increased urinary acetate concentrations. (kingston.ac.uk)
  • Taken together, these results suggest that disease-associated abnormalities in interleukin production may be mediated by different mechanisms with differential sensitivity to the effects of the disease-modifying drug auranofin. (jimmunol.org)
  • See the "Auranofin Precautions" section. (rxwiki.com)
  • Evaluation of mitochondrial respiration demonstrated significant reductions in routine and maximal respiration at both 100nM and 10μM Auranofin. (edu.au)
  • Our data showed that combination therapy with R428 and auranofin markedly inhibited cancer cell proliferation. (biomolther.org)
  • As a partnership, TLC has decided to close the ongoing CLL clinical trial evaluating auranofin. (nih.gov)