Auditory Pathways
Inferior Colliculi
Auditory Diseases, Central
Evoked Potentials, Auditory, Brain Stem
Cochlear Nucleus
Auditory Perception
Cochlear Nerve
Evoked Potentials, Auditory
Auditory Cortex
Olivary Nucleus
Vestibulocochlear Nerve
Auditory Perceptual Disorders
Tinnitus
Hearing
Ear
Brain Stem
Geniculate Bodies
Cochlea
Audiometry, Evoked Response
Sound
Pitch Perception
Audiometry, Pure-Tone
Cochlear Microphonic Potentials
Cochlear Implantation
Event-Related Potentials, P300
Loudness Perception
Gryllidae
Psychoacoustics
Neurons
Functional Laterality
Hearing Loss, Sensorineural
Thalamus
Cochlear Implants
Audiometry
Gerbillinae
Sound Spectrography
Cats
Brain Mapping
Action Potentials
Speech Perception
Chiroptera
Models, Neurological
Electrophysiology
Neural Inhibition
Magnetic Resonance Imaging
Neuronal Plasticity
Synapses
Adaptation, Physiological
Synaptic Transmission
Electroencephalography
Brain
The functional anatomy of the normal human auditory system: responses to 0.5 and 4.0 kHz tones at varied intensities. (1/1597)
Most functional imaging studies of the auditory system have employed complex stimuli. We used positron emission tomography to map neural responses to 0.5 and 4.0 kHz sine-wave tones presented to the right ear at 30, 50, 70 and 90 dB HL and found activation in a complex neural network of elements traditionally associated with the auditory system as well as non-traditional sites such as the posterior cingulate cortex. Cingulate activity was maximal at low stimulus intensities, suggesting that it may function as a gain control center. In the right temporal lobe, the location of the maximal response varied with the intensity, but not with the frequency of the stimuli. In the left temporal lobe, there was evidence for tonotopic organization: a site lateral to the left primary auditory cortex was activated equally by both tones while a second site in primary auditory cortex was more responsive to the higher frequency. Infratentorial activations were contralateral to the stimulated ear and included the lateral cerebellum, the lateral pontine tegmentum, the midbrain and the medial geniculate. Contrary to predictions based on cochlear membrane mechanics, at each intensity, 4.0 kHz stimuli were more potent activators of the brain than the 0.5 kHz stimuli. (+info)Desynchronizing responses to correlated noise: A mechanism for binaural masking level differences at the inferior colliculus. (2/1597)
We examined the adequacy of decorrelation of the responses to dichotic noise as an explanation for the binaural masking level difference (BMLD). The responses of 48 low-frequency neurons in the inferior colliculus of anesthetized guinea pigs were recorded to binaurally presented noise with various degrees of interaural correlation and to interaurally correlated noise in the presence of 500-Hz tones in either zero or pi interaural phase. In response to fully correlated noise, neurons' responses were modulated with interaural delay, showing quasiperiodic noise delay functions (NDFs) with a central peak and side peaks, separated by intervals roughly equivalent to the period of the neuron's best frequency. For noise with zero interaural correlation (independent noises presented to each ear), neurons were insensitive to the interaural delay. Their NDFs were unmodulated, with the majority showing a level of activity approximately equal to the mean of the peaks and troughs of the NDF obtained with fully correlated noise. Partial decorrelation of the noise resulted in NDFs that were, in general, intermediate between the fully correlated and fully decorrelated noise. Presenting 500-Hz tones simultaneously with fully correlated noise also had the effect of demodulating the NDFs. In the case of tones with zero interaural phase, this demodulation appeared to be a saturation process, raising the discharge at all noise delays to that at the largest peak in the NDF. In the majority of neurons, presenting the tones in pi phase had a similar effect on the NDFs to decorrelating the noise; the response was demodulated toward the mean of the peaks and troughs of the NDF. Thus the effect of added tones on the responses of delay-sensitive inferior colliculus neurons to noise could be accounted for by a desynchronizing effect. This result is entirely consistent with cross-correlation models of the BMLD. However, in some neurons, the effects of an added tone on the NDF appeared more extreme than the effect of decorrelating the noise, suggesting the possibility of additional inhibitory influences. (+info)Coding of sound envelopes by inhibitory rebound in neurons of the superior olivary complex in the unanesthetized rabbit. (3/1597)
Most natural sounds (e.g., speech) are complex and have amplitude envelopes that fluctuate rapidly. A number of studies have examined the neural coding of envelopes, but little attention has been paid to the superior olivary complex (SOC), a constellation of nuclei that receive information from the cochlear nucleus. We studied two classes of predominantly monaural neurons: those that displayed a sustained response to tone bursts and those that gave only a response to the tone offset. Our results demonstrate that the off neurons in the SOC can encode the pattern of amplitude-modulated sounds with high synchrony that is superior to sustained neurons. The upper cutoff frequency and highest modulation frequency at which significant synchrony was present were, on average, slightly higher for off neurons compared with sustained neurons. Finally, most sustained and off neurons encoded the level of pure tones over a wider range of intensities than those reported for auditory nerve fibers and cochlear nucleus neurons. A traditional view of inhibition is that it attenuates or terminates neural activity. Although this holds true for off neurons, the robust discharge when inhibition is released adds a new dimension. For simple sounds (i.e., pure tones), the off response can code a wide range of sound levels. For complex sounds, the off response becomes entrained to each modulation, resulting in a precise temporal coding of the envelope. (+info)The superior olivary nucleus and its influence on nucleus laminaris: a source of inhibitory feedback for coincidence detection in the avian auditory brainstem. (4/1597)
Located in the ventrolateral region of the avian brainstem, the superior olivary nucleus (SON) receives inputs from nucleus angularis (NA) and nucleus laminaris (NL) and projects back to NA, NL, and nucleus magnocellularis (NM). The reciprocal connections between the SON and NL are of particular interest because they constitute a feedback circuit for coincidence detection. In the present study, the chick SON was investigated. In vivo tracing studies show that the SON projects predominantly to the ipsilateral NM, NL, and NA. In vitro whole-cell recording reveals single-cell morphology, firing properties, and postsynaptic responses. SON neurons are morphologically and physiologically suited for temporal integration; their firing patterns do not reflect the temporal structure of their excitatory inputs. Of most interest, direct stimulation of the SON evokes long-lasting inhibition in NL neurons. The inhibition blocks both intrinsic spike generation and orthodromically evoked activity in NL neurons and can be eliminated by bicuculline methiodide, a potent antagonist for GABAA receptor-mediated neurotransmission. These results strongly suggest that the SON provides GABAergic inhibitory feedback to laminaris neurons. We discuss a mechanism whereby SON-evoked GABAergic inhibition can influence the coding of interaural time differences for sound localization in the avian auditory brainstem. (+info)Early visual experience shapes the representation of auditory space in the forebrain gaze fields of the barn owl. (5/1597)
Auditory spatial information is processed in parallel forebrain and midbrain pathways. Sensory experience early in life has been shown to exert a powerful influence on the representation of auditory space in the midbrain space-processing pathway. The goal of this study was to determine whether early experience also shapes the representation of auditory space in the forebrain. Owls were raised wearing prismatic spectacles that shifted the visual field in the horizontal plane. This manipulation altered the relationship between interaural time differences (ITDs), the principal cue used for azimuthal localization, and locations of auditory stimuli in the visual field. Extracellular recordings were used to characterize ITD tuning in the auditory archistriatum (AAr), a subdivision of the forebrain gaze fields, in normal and prism-reared owls. Prism rearing altered the representation of ITD in the AAr. In prism-reared owls, unit tuning for ITD was shifted in the adaptive direction, according to the direction of the optical displacement imposed by the spectacles. Changes in ITD tuning involved the acquisition of unit responses to adaptive ITD values and, to a lesser extent, the elimination of responses to nonadaptive (previously normal) ITD values. Shifts in ITD tuning in the AAr were similar to shifts in ITD tuning observed in the optic tectum of the same owls. This experience-based adjustment of binaural tuning in the AAr helps to maintain mutual registry between the forebrain and midbrain representations of auditory space and may help to ensure consistent behavioral responses to auditory stimuli. (+info)Auditory perception: does practice make perfect? (6/1597)
Recent studies have shown that adult humans can learn to localize sounds relatively accurately when provided with altered localization cues. These experiments provide further evidence for experience-dependent plasticity in the mature brain. (+info)Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems. (7/1597)
Thyroid hormone is an important epigenetic factor in brain development, acting by modulating rates of gene expression. The active form of thyroid hormone, 3,5,3'-triiodothyronine (T3) is produced in part by the thyroid gland but also after 5'-deiodination of thyroxine (T4) in target tissues. In brain, approximately 80% of T3 is formed locally from T4 through the activity of the 5'-deiodinase type 2 (D2), an enzyme that is expressed mostly by glial cells, tanycytes in the third ventricle, and astrocytes throughout the brain. D2 activity is an important point of control of thyroid hormone action because it increases in situations of low T4, thus preserving brain T3 concentrations. In this work, we have studied the expression of D2 by quantitative in situ hybridization in hypothyroid animals during postnatal development. Our hypothesis was that those regions that are most dependent on thyroid hormone should present selective increases of D2 as a protection against hypothyroidism. D2 mRNA concentration was increased severalfold over normal levels in relay nuclei and cortical targets of the primary somatosensory and auditory pathways. The results suggest that these pathways are specifically protected against thyroid failure and that T3 has a role in the development of these structures. At the cellular level, expression was observed mainly in glial cells, although some interneurons of the cerebral cortex were also labeled. Therefore, the T3 target cells, mostly neurons, are dependent on local astrocytes for T3 supply. (+info)Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. (8/1597)
The common occurrence of hearing loss in both humans and mice, and the anatomical and functional similarities of their inner ears, attest to the potential of mice being used as models to study inherited hearing loss. A large-scale, auditory screening project is being undertaken at The Jackson Laboratory (TJL) to identify mice with inherited hearing disorders. To assess hearing sensitivity, at least five mice from each inbred strain had auditory brainstem response (ABR) thresholds determined. Thus far, we have screened 80 inbred strains of mice; 60 of them exhibited homogeneous ABR threshold values not significantly different from those of the control strain CBA/CaJ. This large database establishes a reliable reference for normal hearing mouse strains. The following 16 inbred strains exhibited significantly elevated ABR thresholds before the age of 3 months: 129/J, 129/ReJ, 129/SvJ, A/J, ALR/LtJ, ALS/LtJ, BUB/BnJ, C57BLKS/J, C57BR/cdJ, C57L/J, DBA/2J, I/LnJ, MA/MyJ, NOD/LtJ, NOR/LtJ, and SKH2/J. These hearing impaired strains may serve as models for some forms of human non-syndromic hearing loss and aid in the identification of the underlying genes. (+info)Some examples of central auditory diseases include:
1. Central auditory processing disorder (CAPD): A condition where the brain has difficulty processing sounds, leading to difficulties with speech and language development, reading, and social interactions.
2. Auditory neuropathy spectrum disorder (ANSD): A condition that affects the transmission of sound from the inner ear to the brain, leading to difficulties with hearing and understanding speech.
3. Chronic suppurative otitis media (CSOM): A condition that causes chronic inflammation and infection of the middle ear, which can lead to hearing loss and difficulty processing sound.
4. Meniere's disease: A condition that affects the inner ear and causes vertigo, tinnitus, and hearing loss.
5. Acoustic neuroma: A benign tumor that grows on the nerve that connects the inner ear to the brain, leading to hearing loss, tinnitus, and balance difficulties.
6. Stroke or traumatic brain injury: These conditions can damage the auditory system and cause hearing loss or difficulty understanding speech.
7. Cochlear implant complications: Complications related to the surgical implantation of a cochlear implant, such as infection or device malfunction, can affect the central auditory system.
8. Chronic tinnitus: A condition characterized by persistent ringing or other sounds in the ears that can lead to hearing loss and difficulty understanding speech.
9. Ototoxicity: Exposure to certain medications or chemicals can damage the inner ear and cause hearing loss or tinnitus.
10. Meningitis or encephalitis: Infections of the brain and its membranes can affect the auditory system and cause hearing loss, tinnitus, and balance difficulties.
These are just a few examples of central auditory diseases. The diagnosis and treatment of these conditions typically involve a team of healthcare professionals, including otolaryngologists (ENT specialists), neurologists, audiologists, and speech-language pathologists.
There are several subtypes of APD, including:
1. Auditory Processing Disorder (APD): A disorder characterized by difficulty processing auditory information due to a deficit in the brain's ability to process speech and language.
2. Central Auditory Processing Disorder (CAPD): A subtype of APD that is caused by a problem in the central nervous system, rather than in the inner ear.
3. Developmental Auditory Perceptual Disorder (DAPD): A disorder that affects children and adolescents, characterized by difficulty with auditory perception and processing.
4. Auditory Memory Deficit: A subtype of APD that is characterized by difficulty with auditory memory and recall.
5. Auditory Discrimination Deficit: A subtype of APD that is characterized by difficulty with distinguishing between similar sounds.
APD can be caused by a variety of factors, including genetics, premature birth, infections during pregnancy or childhood, and head trauma. Treatment for APD typically involves a combination of behavioral therapies, such as auditory training and speech therapy, as well as assistive listening devices and technology.
In addition to the subtypes listed above, there are also several related conditions that may be classified as APD, including:
1. Auditory-Verbal Processing Disorder (AVPD): A disorder characterized by difficulty with auditory processing and language development.
2. Language Processing Deficit: A subtype of APD that is characterized by difficulty with language comprehension and processing.
3. Attention Deficit Hyperactivity Disorder (ADHD): A neurodevelopmental disorder that can also affect auditory perception and processing.
4. Autism Spectrum Disorder (ASD): A neurodevelopmental disorder that can also affect auditory perception and processing, as well as social communication and behavior.
5. Central Auditory Processing Disorder (CAPD): A type of APD that is characterized by difficulty with central auditory processing, including the ability to understand speech in noisy environments.
There is no cure for tinnitus, but there are several treatment options available to help manage the condition. These include sound therapy, which involves exposing the ear to soothing sounds to mask the tinnitus, and counseling, which can help individuals cope with the emotional effects of tinnitus. Other treatments may include medications to relieve anxiety or depression, relaxation techniques, and lifestyle changes such as avoiding loud noises and taking steps to reduce stress.
It is important for individuals who experience tinnitus to seek medical attention if the condition persists or worsens over time, as it can be a symptom of an underlying medical condition that requires treatment. A healthcare professional can evaluate the individual's hearing and overall health to determine the cause of the tinnitus and develop an appropriate treatment plan.
There are several types of deafness, including:
1. Conductive hearing loss: This type of deafness is caused by problems with the middle ear, including the eardrum or the bones of the middle ear. It can be treated with hearing aids or surgery.
2. Sensorineural hearing loss: This type of deafness is caused by damage to the inner ear or auditory nerve. It is typically permanent and cannot be treated with medication or surgery.
3. Mixed hearing loss: This type of deafness is a combination of conductive and sensorineural hearing loss.
4. Auditory processing disorder (APD): This is a condition in which the brain has difficulty processing sounds, even though the ears are functioning normally.
5. Tinnitus: This is a condition characterized by ringing or other sounds in the ears when there is no external source of sound. It can be a symptom of deafness or a separate condition.
There are several ways to diagnose deafness, including:
1. Hearing tests: These can be done in a doctor's office or at a hearing aid center. They involve listening to sounds through headphones and responding to them.
2. Imaging tests: These can include X-rays, CT scans, or MRI scans to look for any physical abnormalities in the ear or brain.
3. Auditory brainstem response (ABR) testing: This is a test that measures the electrical activity of the brain in response to sound. It can be used to diagnose hearing loss in infants and young children.
4. Otoacoustic emissions (OAE) testing: This is a test that measures the sounds produced by the inner ear in response to sound. It can be used to diagnose hearing loss in infants and young children.
There are several ways to treat deafness, including:
1. Hearing aids: These are devices that amplify sound and can be worn in or behind the ear. They can help improve hearing for people with mild to severe hearing loss.
2. Cochlear implants: These are devices that are implanted in the inner ear and can bypass damaged hair cells to directly stimulate the auditory nerve. They can help restore hearing for people with severe to profound hearing loss.
3. Speech therapy: This can help people with hearing loss improve their communication skills, such as speaking and listening.
4. Assistive technology: This can include devices such as captioned phones, alerting systems, and assistive listening devices that can help people with hearing loss communicate more effectively.
5. Medications: There are several medications available that can help treat deafness, such as antibiotics for bacterial infections or steroids to reduce inflammation.
6. Surgery: In some cases, surgery may be necessary to treat deafness, such as when there is a blockage in the ear or when a tumor is present.
7. Stem cell therapy: This is a relatively new area of research that involves using stem cells to repair damaged hair cells in the inner ear. It has shown promising results in some studies.
8. Gene therapy: This involves using genes to repair or replace damaged or missing genes that can cause deafness. It is still an experimental area of research, but it has shown promise in some studies.
9. Implantable devices: These are devices that are implanted in the inner ear and can help restore hearing by bypassing damaged hair cells. Examples include cochlear implants and auditory brainstem implants.
10. Binaural hearing: This involves using a combination of hearing aids and technology to improve hearing in both ears, which can help improve speech recognition and reduce the risk of falls.
It's important to note that the best treatment for deafness will depend on the underlying cause of the condition, as well as the individual's age, overall health, and personal preferences. It's important to work with a healthcare professional to determine the best course of treatment.
This type of hearing loss cannot be treated with medication or surgery, and it is usually permanent. However, there are various assistive devices and technology available to help individuals with sensorineural hearing loss communicate more effectively, such as hearing aids, cochlear implants, and FM systems.
There are several causes of sensorineural hearing loss, including:
1. Exposure to loud noises: Prolonged exposure to loud noises can damage the hair cells in the inner ear and cause permanent hearing loss.
2. Age: Sensorineural hearing loss is a common condition that affects many people as they age. It is estimated that one-third of people between the ages of 65 and 74 have some degree of hearing loss, and nearly half of those over the age of 75 have significant hearing loss.
3. Genetics: Some cases of sensorineural hearing loss are inherited and run in families.
4. Viral infections: Certain viral infections, such as meningitis or encephalitis, can damage the inner ear and cause permanent hearing loss.
5. Trauma to the head or ear: A head injury or a traumatic injury to the ear can cause sensorineural hearing loss.
6. Tumors: Certain types of tumors, such as acoustic neuroma, can cause sensorineural hearing loss by affecting the auditory nerve.
7. Ototoxicity: Certain medications, such as certain antibiotics, chemotherapy drugs, and aspirin at high doses, can be harmful to the inner ear and cause permanent hearing loss.
It is important to note that sensorineural hearing loss cannot be cured, but there are many resources available to help individuals with this condition communicate more effectively and improve their quality of life.
Cochlear nucleus
Stria vascularis of cochlear duct
Animal echolocation
Optogenetics
Channelrhodopsin
Spiral ganglion
Auditory system
Feature detection (nervous system)
Cat intelligence
Aage Møller
Northern saw-whet owl
Mriganka Sur
Sensitivity and specificity
Sense
HVC (avian brain region)
Sarah Pallas
Anna Wang Roe
Up from Dragons
Cartilage conduction
Cerebellopontine angle syndrome
KCNQ4
Prestin
Transverse temporal gyrus
Pejvakin
Inhibitory postsynaptic potential
Binaural fusion
Reproduction and vocalization in midshipman fish
Columella (auditory system)
Auditory brainstem response
Evolutionary neuroscience
Psychology of religion
CLINT1
Jack Pettigrew
Psychological stress and sleep
Listener fatigue
Computational audiology
Speech shadowing
Visual learning
Effects of cannabis
Coffin-Lowry syndrome
Brachium colliculi
Acoustic reflex
Motion perception
Efference copy
Stroop effect
Macropsia
Superior temporal gyrus
Bioarchaeology
Brain-computer interface
Temnospondyli
Apperceptive agnosia
Vasyl Moroz
Craniopagus twins
Environment and intelligence
Risk factors of schizophrenia
Illinois State University College of Arts and Sciences
Synaptic noise
Orville Hungerford
Temporal envelope and fine structure
Olivocochlear system
Constructing noise-invariant representations of sound in the auditory pathway
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MeSH Browser
Cortex9
- We measured these forms of adaptation by presenting complex synthetic and natural sounds, recording neuronal responses in the inferior colliculus and primary fields of the auditory cortex of anaesthetized ferrets, and comparing these responses with a sophisticated model of the auditory nerve. (nih.gov)
- This suggests that the increase in adaptation to sound statistics from auditory nerve to midbrain to cortex is an important stage in the construction of noise-invariant sound representations in the higher auditory brain. (nih.gov)
- This was accompanied by reduced neural responses to gaps in auditory cortex , the auditory periphery, and auditory brainstem . (bvsalud.org)
- The auditory cortex (AC) sends long-range projections to virtually all subcortical auditory structures. (nih.gov)
- Layer 5 corticocollicular neurons are concentrated in primary AC, while layer 6 corticocollicular neurons emanate from broad auditory and limbic areas in the temporal cortex. (nih.gov)
- Responses of primary auditory cortex (A1) neurons to frequency-modulated (FM) tones are heterogenic in awake cats. (actapress.com)
- NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM , beginning at the hair cells of the ORGAN OF CORTI , continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX . (nih.gov)
- connection with auditory cortex and may be associated with disabling consequences usually requiring rehabilitation. (who.int)
- Dissociation of Unit Activity and Gamma Oscillations during Vocalization in Primate Auditory Cortex. (duke.edu)
Nerve6
- Central hearing loss results from damage to the auditory nerve itself, or the brain pathways that lead to the nerve. (medlineplus.gov)
- This test uses patches, called electrodes, to see how the auditory nerve reacts to sound. (medlineplus.gov)
- The model consists of seven blocks: the basilar membrane (BM), the inner hair cell (IHC), the primary auditory nerve (AN), the ventral cochlear nucleus (VCN), the inferior colliculus (IC), the medial geniculate body (MGB), and the A1 neuron. (actapress.com)
- in the cochlear, auditory nerve, neural pathway or their type and severity of hearing loss. (who.int)
- This computerized test evaluates how well sounds travel along the hearing nerve pathways from the ear to the brainstem. (uthsc.edu)
- The Auditory Brainstem Response (ABR) evaluation may be ordered for older children or adults following a traditional hearing test battery to further access the auditory nerve and the pathways along the brainstem. (uthsc.edu)
Neural Pathways1
- Ribbon synapses are specialized neuron connections found in ocular and auditory neural pathways, and their health is critical to the function of retinal photoreceptors in the eye, as well as hair cells in the ear. (nih.gov)
Brainstem response2
- The auditory brainstem response (ABR) is an objective measure of the overall auditory transduction process. (bmj.com)
- The Auditory Brainstem Response (ABR) evaluation is commonly used for infants and toddlers, or anyone who cannot cooperate with traditional hearing testing, to accurately measure hearing status. (uthsc.edu)
Dual pathway model2
- Lateralization of auditory language functions: A dynamic dual pathway model. (mpg.de)
- Assessing the auditory dual-pathway model in humans. (bvsalud.org)
Neurons4
- Cochlear outer hair cells (OHCs) are known to uniquely participate in auditory processing through their electromotility, and like inner hair cells, are also capable of releasing vesicular glutamate onto spiral ganglion (SG) neurons: in this case, onto the sparse Type II SG neurons. (nih.gov)
- To explain the FM responses of A1 neurons, we developed an auditory model with a multichannel neural pathway. (actapress.com)
- Here, we show that in zebrafish, less precipitous threats elicit a delayed escape, characterized by flexible trajectories, which are driven by a cluster of 38 prepontine neurons that are completely separate from the fast escape pathway. (nih.gov)
- Whereas neurons that initiate rapid escapes receive direct auditory input and drive motor neurons, input and output pathways for delayed escapes are indirect, facilitating integration of cross-modal sensory information. (nih.gov)
Otoacoustic3
- The otoacoustic emissions (OAEs) test is another objective measure of the auditory pathway, which detects responses of the outer hair cells (OHCs) to environmental sound. (bmj.com)
- Similar to findings among young adults, children with HIV in Tanzania were found to have lower distortion product otoacoustic emissions (DPOAEs) and auditory brainstem responses (ABR) wave V amplitudes, compared with children without HIV. (ajmc.com)
- Despite having clinically normal hearing, research shows that children living with HIV (CLWH) in Tanzania have lower distortion product otoacoustic emissions (DPOAEs) and lower auditory brainstem responses (ABR) wave V amplitudes, compared with children without HIV. (ajmc.com)
Signals5
- Early-Life Stress Impairs Perception and Neural Encoding of Rapid Signals in the Auditory Pathway. (bvsalud.org)
- However, the circuits by which conspecific auditory signals are perceived, processed, and stored in long- term memory have not been well documented. (elsevierpure.com)
- We have documented two points at which the vocal motor pathway may pick up auditory signals: the HVC-shelf interface and a projection from clHV to the nucleus interfacialis (NIf), which projects to HVC. (elsevierpure.com)
- This model can be used to convert acoustical signals into electrical stimuli as part of an auditory brain-machine interface for individuals with severe hearing impairments. (actapress.com)
- Pathway-Specific Asymmetries between ON and OFF Visual Signals. (duke.edu)
Stimulation2
- Here we investigated the extent of neuronal adaptation to the mean and contrast of auditory stimulation as one ascends the auditory pathway. (nih.gov)
- Here, we recorded neuronal activity in the ventral intermediate nucleus as well as the ventral oral anterior, and posterior nuclei of the motor thalamus in 25 patients with parkinsonian ( n = 6) and non-parkinsonian tremors ( n = 19) prior to insertion of deep brain stimulation electrodes while they performed an auditory oddball task. (nature.com)
Thalamus2
- By using injections of different kinds of neuroanatomical tracers (biotinylated dextran amines, rhodamine-linked dextran amines, biocytin, fluorogold, and rhodamine-linked latex beads), we have shown that, as in other avian groups, the neostriatal field L complex in caudal telencephalon is the primary forebrain relay for pathways originating in the auditory thalamus, i.e., the nucleus ovoidalis complex (Ov). (elsevierpure.com)
- The current study demonstrated that ascending information to the motor thalamus can be suppressed during auditory attending tasks, providing indirect evidence for the searchlight hypothesis in humans. (nature.com)
Responses2
- Here, we demonstrate that ELS degrades sensory responses to rapid variations in sound at multiple levels of the auditory pathway , and concurrently impairs perception of these rapidly-varying sounds . (bvsalud.org)
- The magnitude of these differences was small, but results suggest an early and consistent association between HIV infection or treatment and outer hair cell and auditory brainstem responses in children as young as 3 years," the study authors said. (ajmc.com)
Inhibition1
- Inhibition was specific to auditory attention as incorrect counting or wrist flicking to the deviant tones did not produce such inhibition. (nature.com)
Cochlear synaptopathy2
- Cochlear synaptopathy produced by exposure to noise levels that cause only transient auditory threshold elevations is a condition that affects many people and is believed to contribute to poor speech discrimination in noisy environments. (jneurosci.org)
- In Chrna9 KO ears, noise exposure produced permanent auditory threshold elevations together with cochlear synaptopathy. (jneurosci.org)
Peripheral1
- Hearing loss can occur after ingestion of certain drugs due to their effects on the peripheral auditory system or central nervous system. (cdc.gov)
Ototoxic2
- The mechanisms of action of ototoxic substances may involve the entire organ, specific cells within the organ, components of specific cells, or individual biochemical pathways. (cdc.gov)
- Drugs and other substances that alter hearing or equilibrium by acting primarily at the level of the brain stem or the central auditory pathways are considered to be neurotoxic and not strictly ototoxic (Hawkins 1976). (cdc.gov)
Inferior1
- 17. Decreased integrity of the fronto-temporal fibers of the left inferior occipito-frontal fasciculus associated with auditory verbal hallucinations in schizophrenia. (nih.gov)
Perception1
- In particular, the perception and auditory cortical (ACx) encoding of temporally-varying sounds both mature gradually, even into adolescence , providing an extended postnatal window of susceptibility. (bvsalud.org)
Selective1
- The neurophysiology of selective attention in visual and auditory systems has been studied in animal models but not with single unit recordings in human. (nature.com)
Ears1
- Providing both ears with early input ensures the auditory pathways are supported to maximise a child's development. (cochlear.com)
System10
- Identifying behaviorally relevant sounds in the presence of background noise is one of the most important and poorly understood challenges faced by the auditory system. (nih.gov)
- An elegant solution to this problem would be for the auditory system to represent sounds in a noise-invariant fashion. (nih.gov)
- Hearing loss can happen when any part of the ear or auditory (hearing) system is not working in the usual way. (cdc.gov)
- These data represent the most complete survey to date of auditory pathways in the adult male zebra finch brain, and of their projections to motor stations of the song system. (elsevierpure.com)
- His laboratory investigates these mechanisms using excitatory and inhibitory brainstem pathways in the mammalian sound localization system. (nih.gov)
- Evidence for Layer-Specific Connectional Heterogeneity in the Mouse Auditory Corticocollicular System. (nih.gov)
- For patients with single-sided Ménière's disease and profound sensorineural hearing loss the simultaneous labyrinthectomy and cochlear implantation are efficient method for the treatment of vertigo as well as the rehabilitation of the auditory system. (hindawi.com)
- For this reason, this study examines the success of simultaneous labyrinthectomy for the therapy of vertigo and cochlear implantation for the rehabilitation of the auditory system. (hindawi.com)
- The Language Power-Lock System employs an integrated switchback method to engage the learner through visual, auditory, and psychomotor pathways. (greateracadianaregion.net)
- Since then, considerable progress toward understanding the effects of certain environmental and occupational chemicals on the auditory system and their interactions with noise has been made (Fechter et al. (cdc.gov)
Circuits1
- In particular, no evidence exists of direct connections between auditory and vocal motor pathways, and two newly identified centers for auditory processing, caudomedial neostriatum (Ncm) and caudomedial hyperstriatum ventrale (cmHV), have no documented place among known auditory circuits. (elsevierpure.com)
Brain4
- Sequential effects of propofol on functional brain activation induced by auditory language processing: An event-related functional magnetic resonance imaging study. (mpg.de)
- Auditory brain stem response (ABR) test. (medlineplus.gov)
- These pathways conduct sound from the inner ear to the brain. (uthsc.edu)
- In addition to the NIH Director's New Innovator Award, his lab is supported by the Searle Scholars Program, The Pew Scholars Program in the Biomedical Sciences, The Kathryn W. Davis Aging Brain Scholars Program and an NIH Pathway to Independence Award. (nih.gov)
Adult1
- Our goal was to describe anatomically the auditory pathways in adult zebra finch males and, specifically, to show the projections by which Ncm and vocal motor centers may receive auditory input. (elsevierpure.com)
Audiology1
- The units you select once you are enrolled will ensure you are on the paediatric pathway and receive an MSc in Audiology (Paediatric) on successful completion. (manchester.ac.uk)
Model1
- To examine the effects of ELS on temporal processing , we developed a model of ELS in the Mongolian gerbil , a well-established model for auditory processing . (bvsalud.org)
Processes2
- In this seminar, Dr. Kandler will focus on the processes and mechanisms that occur during the topographic refinement of an inhibitory, GABA/glycinergic pathway (MNTB-LSO pathway). (nih.gov)
- This Funding Opportunity Announcement (FOA) supersedes the previous National Institute on Deafness and Other Communication Disorders (NIDCD) program announcement, "Proteomics in Auditory Developmental and Disease Processes" (PA-06-366). (nih.gov)
Drugs1
- In the developed nations, and in some developing ones, the prescription of these drugs will trigger "ototoxicity monitoring" of patients to allow early detection of auditory effects and, when necessary, audiologic interventions to address the hearing impairment (AAA 2009). (cdc.gov)
Patients4
- 5. Microstructural alterations of the arcuate fasciculus in schizophrenia patients with frequent auditory verbal hallucinations. (nih.gov)
- 12. Integrity of the arcuate fasciculus in patients with schizophrenia with auditory verbal hallucinations: A DTI-tractography study. (nih.gov)
- 13. Independent contribution of individual white matter pathways to language function in pediatric epilepsy patients. (nih.gov)
- 15. Local Alterations of Left Arcuate Fasciculus and Transcallosal White Matter Microstructure in Schizophrenia Patients with Medication-resistant Auditory Verbal Hallucinations: A Pilot Study. (nih.gov)
Hearing3
- Since a hearing defect might occur at any place along the auditory pathway, it would seem reasonable to expect to be able to differentiate types of NSRHL based on the location where the auditory process is disrupted. (bmj.com)
- Pure tone audiometry has been the standard method used to measure hearing threshold but, since it subjectively tests the overall integrity of the auditory pathway, it gives only limited information about where that pathway is failing. (bmj.com)
- This type of hearing loss has been defined as auditory neuropathy (AN). (bmj.com)
Response1
- The majority of attendees accepted the terminology used in 2-year studies for describing the strength of response in p53+/- and Hras2 models where the altered gene is in a pathway leading to a carcinogenic outcome. (nih.gov)
Early1
- This commercially available program combines advanced psychoacoustic techniques with the improvisational art of Ostad Elahi (1895-1974) to encourage active listening (a central component of mindfulness practice) by targeting early auditory information processing pathways. (brunel.ac.uk)
Found1
- 3- 6 A good review of auditory tests can be found in Hood. (bmj.com)
Function1
- The researchers called these differences subtle but significant, and warrant tracking auditory function and development outcomes in CLWH. (ajmc.com)
Addition1
- In addition, Elahi's fingering and striking technique convey the auditory impression of simultaneous dissonance and consonance, creating polyphonic effects. (brunel.ac.uk)
Effects1
- The specificity of the effects could not be explained by auditory confounds. (frontiersin.org)
Critical1
- Auditory information is critical for vocal imitation and other elements of social life in songbirds. (elsevierpure.com)
Complex1
- Parts of the field L complex are connected among themselves and to Ncm, cmHV, and caudolateral HV (clHV) through a complex web of largely reciprocal pathways. (elsevierpure.com)