AU Rich Elements: RNA sequences composed of ADENINE NUCLEOTIDES and URACIL NUCLEOTIDES, that are located in the 3'UNTRANSLATED REGIONS of MESSENGER RNA molecules that are rapidly degraded. They are also known as AREs.Hu Paraneoplastic Encephalomyelitis Antigens: A family of RNA-binding proteins that are homologues of ELAV protein, Drosophila. They were initially identified in humans as the targets of autoantibodies in patients with PARANEOPLASTIC ENCEPHALOMYELITIS. They are thought to regulate GENE EXPRESSION at the post-transcriptional level.RNA Stability: The extent to which an RNA molecule retains its structural integrity and resists degradation by RNASE, and base-catalyzed HYDROLYSIS, under changing in vivo or in vitro conditions.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)3' Untranslated Regions: The sequence at the 3' end of messenger RNA that does not code for product. This region contains transcription and translation regulating sequences.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Tristetraprolin: A ZINC FINGER MOTIF containing transcription factor that was originally identified as one of the IMMEDIATE-EARLY PROTEINS. It shuttles between the CYTOPLASM and the CELL NUCLEUS and is involved in destabilization of mRNAs for TUMOR NECROSIS FACTOR-ALPHA.Heterogeneous-Nuclear Ribonucleoprotein D: A heterogeneous-nuclear ribonucleoprotein that has specificity for AU-rich elements found in the 3'-region of mRNA and may play a role in RNA stability. Several isoforms of hnRNP D protein have been found to occur due to alternative mRNA splicing (RNA SPLICING).p38 Mitogen-Activated Protein Kinases: A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.Mitogen-Activated Protein Kinases: A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).Poly(A)-Binding Proteins: Proteins that bind to the 3' polyadenylated region of MRNA. When complexed with RNA the proteins serve an array of functions such as stabilizing the 3' end of RNA, promoting poly(A) synthesis and stimulating mRNA translation.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.RNA-Binding Proteins: Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.Silencer Elements, Transcriptional: Nucleic acid sequences that are involved in the negative regulation of GENETIC TRANSCRIPTION by chromatin silencing.Furin: A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.Cyclin D2: A cyclin D subtype which is regulated by GATA4 TRANSCRIPTION FACTOR. Experiments using KNOCKOUT MICE suggest a role for cyclin D2 in granulosa cell proliferation and gonadal development.Cyclin D3: A broadly expressed type D cyclin. Experiments using KNOCKOUT MICE suggest a role for cyclin D3 in LYMPHOCYTE development.Cyclin A: A cyclin subtype that has specificity for CDC2 PROTEIN KINASE and CYCLIN-DEPENDENT KINASE 2. It plays a role in progression of the CELL CYCLE through G1/S and G2/M phase transitions.Cyclin D: A cyclin subtype that is specific for CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. Unlike most cyclins, cyclin D expression is not cyclical, but rather it is expressed in response to proliferative signals. Cyclin D may therefore play a role in cellular responses to mitogenic signals.Cyclin E: A 50-kDa protein that complexes with CYCLIN-DEPENDENT KINASE 2 in the late G1 phase of the cell cycle.Eels: Common name for an order (Anguilliformes) of voracious, elongate, snakelike teleost fishes.Smegmamorpha: Group of fish under the superorder Acanthopterygii, separate from the PERCIFORMES, which includes swamp eels, mullets, sticklebacks, seahorses, spiny eels, rainbowfishes, and KILLIFISHES. The name is derived from the six taxa which comprise the group. (From http://www.nanfa.org/articles/Elassoma/elassoma.htm, 8/4/2000)Glutamate Dehydrogenase: An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2.Gnathostomiasis: Infections with nematodes of the genus GNATHOSTOMA, superfamily THELAZIOIDEA. Gnathostomiasis is a food-borne zoonosis caused by eating undercooked or raw fish or meat.Oncorhynchus mykiss: A large stout-bodied, sometimes anadromous, TROUT found in still and flowing waters of the Pacific coast from southern California to Alaska. It has a greenish back, a whitish belly, and pink, red, or lavender stripes on the sides, with usually a sprinkling of black dots. It is highly regarded as a sport and food fish. Its former name was Salmo gairdneri. The sea-run rainbow trouts are often called steelheads. Redband trouts refer to interior populations of rainbows.Salmo salar: A commercially important species of SALMON in the family SALMONIDAE, order SALMONIFORMES, which occurs in the North Atlantic.Ammonia: A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.Exosome Multienzyme Ribonuclease Complex: An intracellular ribonucleolytic protein complex that participates in POSTRANSCRIPTIONAL RNA PROCESSING and RNA DEGRADATION.Olivopontocerebellar Atrophies: A group of inherited and sporadic disorders which share progressive ataxia in combination with atrophy of the CEREBELLUM; PONS; and inferior olivary nuclei. Additional clinical features may include MUSCLE RIGIDITY; NYSTAGMUS, PATHOLOGIC; RETINAL DEGENERATION; MUSCLE SPASTICITY; DEMENTIA; URINARY INCONTINENCE; and OPHTHALMOPLEGIA. The familial form has an earlier onset (second decade) and may feature spinal cord atrophy. The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. (From Adams et al., Principles of Neurology, 6th ed, p1085)Exoribonucleases: A family of enzymes that catalyze the exonucleolytic cleavage of RNA. It includes EC 3.1.13.-, EC 3.1.14.-, EC 3.1.15.-, and EC 3.1.16.-. EC 3.1.-Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Exosomes: A type of extracellular vesicle, containing RNA and proteins, that is secreted into the extracellular space by EXOCYTOSIS when MULTIVESICULAR BODIES fuse with the PLASMA MEMBRANE.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Saudi ArabiaNigeria: A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.5' Untranslated Regions: The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.Untranslated Regions: The parts of the messenger RNA sequence that do not code for product, i.e. the 5' UNTRANSLATED REGIONS and 3' UNTRANSLATED REGIONS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Alcohol-Related Disorders: Disorders related to or resulting from abuse or mis-use of alcohol.Legal Guardians: A legal concept for individuals who are designated to act on behalf of persons who are considered incapable of acting in their own behalf, e.g., minors and persons found to be not mentally competent.Aversive Therapy: A treatment that suppresses undesirable behavior by simultaneously exposing the subject to unpleasant consequences.RNA: A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Sirtuin 1: A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.Alternative Splicing: A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.RNA Splicing: The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.Sirtuins: A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.

Perspectives on the ARE as it turns 25 years old. (1/25)

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Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1. (2/25)

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Multilevel regulation of HIF-1 signaling by TTP. (3/25)

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dTIS11 Protein-dependent polysomal deadenylation is the key step in AU-rich element-mediated mRNA decay in Drosophila cells. (4/25)

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AU-rich elements in the 3'-UTR regulate the stability of the 141 amino acid isoform of parathyroid hormone-related protein mRNA. (5/25)

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AUF1/hnRNP D is a novel protein partner of the EBER1 noncoding RNA of Epstein-Barr virus. (6/25)

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The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation. (7/25)

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The ribosome binding site of a mini-ORF protects a T3SS mRNA from degradation by RNase E. (8/25)

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Selective mRNA turnover is an important mechanism of eukaryotic gene regulation. The expression of proto‐oncogenes, lymphokines and cytokines is usually transient, requiring rapid mRNA removal through destabilization following the cessation of transcription. AU‐rich elements (AREs) located in their 3′ untranslated regions (3′ UTRs) comprise a major class of cis‐elements that target these mRNAs for rapid degradation (Caput et al., 1986; Shaw and Kamen, 1986; for reviews, see Belasco and Brawerman, 1993; Chen and Shyu, 1995). Loss of this negative regulatory control conferred by AREs has been shown to be associated with transforming phenotypes (Miller et al., 1984; Meijlink et al., 1985; Lee,W. et al., 1988). Besides mRNAs, small nuclear RNAs (snRNAs) can also be targeted by AREs for rapid degradation, presumably through similar decay pathway(s) (Fan et al., 1997). ARE‐mediated decay may also be differentially regulated. For instance, in a monocyte tumor cell line, c‐fos mRNA is ...
Complete information for SMG6 gene (Protein Coding), SMG6, Nonsense Mediated MRNA Decay Factor, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
We found significant enrichment for Pumilio targets only in classes with zygotic decay contributions (classes IV and V; Figure 8a), consistent with its proposed role in zygotic decay activities [46]. The minor enrichment in Pumilio targets within the stable mRNA class (class I) was statistically insignificant.. Smaug targets were significantly enriched in classes III and V, both of which show maternal decay activities, while no enrichment is seen in the exclusively zygotic decay class IV (Figure 8b). These observations are in line with the maternal origin of Smaug [28]. Given that Smaug had been shown to be an important, maternally provided mRNA decay factor [43, 74], the absence of significant (P = 0.42) enrichment of its targets within the maternal decay only class (II) was somewhat unexpected. The maximum enrichment (13-fold) of Smaug targets was detected in the mixed decay class (V). A plausible explanation for these observations might be that Smaug requires additional, zygotic decay ...
TELO2 interacting protein 1 is a human homolog of the S. pombe Tel2 interacting protein 1, and is encoded by the TTI1 gene. It is part of the TTT complex that is required to stabilize the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. This complex regulates the response to DNA damage caused by radiation or DNA cross-linking agents. TTI1 also promotes the assembly, stabilizes, and maintains the activity of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2; these complexes are responsible for regulating cell growth and survival in response to nutrient and hormonal signals. TTI1 is also known as Tel2 interacting protein 1 homolog (S. pombe); Tel2 interacting protein 1 homolog, KIAA0406, and smg-10 homolog, nonsense mediated mRNA decay factor (SMG10).. ...
TELO2 interacting protein 1 is a human homolog of the S. pombe Tel2 interacting protein 1, and is encoded by the TTI1 gene. It is part of the TTT complex that is required to stabilize the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. This complex regulates the response to DNA damage caused by radiation or DNA cross-linking agents. TTI1 also promotes the assembly, stabilizes, and maintains the activity of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2; these complexes are responsible for regulating cell growth and survival in response to nutrient and hormonal signals. TTI1 is also known as Tel2 interacting protein 1 homolog (S. pombe); Tel2 interacting protein 1 homolog, KIAA0406, and smg-10 homolog, nonsense mediated mRNA decay factor (SMG10).. ...
The antitumor activities of cytolytic T lymphocytes and natural killer cells are being increasingly investigated and exploited in cancer immunotherapy. One mechanism by which these cells recognize tumor cells is by engagement of NKG2D, an activating receptor on cytolytic T lymphocytes and natural killer cells, by MICA/B and ULBP family stress antigens.. In a study reported in Science Translational Medicine, Vantourout and colleagues showed that activation of EGFR is responsible for surface upregulation of NKG2D ligands in human epithelial cells in response to ultraviolet irradiation, osmotic shock, oxidative stress, and growth factor exposure. EGFR activation results in intracellular relocalization of adenylate-uridylate (AU)-rich element RNA-binding protein 1 (AUF1); AUF1 proteins normally destabilize NKG2D ligand mRNAs by targeting an AU-rich element that is conserved in the 3′ ends of most human, but not murine, NKG2D ligand genes. NKG2D ligand expression was positively correlated with EGFR ...
Many genes are essential for early development and, as their inactivation leads to early embryonic lethality, this precludes further investigation of their functions in late embryonic and postnatal development. The cKO strategy overcomes this obstacle and allows for dissection of gene function in a cell lineage-specific and temporally controlled fashion. In this study, we employed an SC-specific Cre line (i.e. Amh-Cre) to inactivate Upf2 exclusively in SCs at ∼E12.5 so that the role of Upf2 in SC development could be delineated. The dual-fluorescent reporter (Rosa26mTmG) line allows for easy and convenient determination of the onset of Cre activity when crossed with a specific Cre deletor line (Wu et al., 2012). Using this method, we detected Cre activity in Amh-Cre males at ∼E12.5, which is ∼2 days earlier than in an alternative Amh-Cre line (∼E14.5) (Gao et al., 2006; Kim et al., 2010). At E12.5, SC specification has completed and the testis cord has just become morphologically ...
Figure 7. siRNA-mediated depletion of 4E-T affects mRNA turnover. HeLa cells were transfected with siRNA against 4E-T or a control (Ctrl) siRNA (4AIII inverted). Protein and RNA were harvested for use in Western (C and D) and Northern (A, B, and E) analysis, respectively. (A and B) HeLa cells were transfected with siRNA against 4E-T or with control siRNA and later cotransfected with pTet-β-globin or pTet-β-globin c-fos or GM-CSF ARE and pTet Off. Cells were treated with doxycycline (1 μg/ml) ∼72 h after transfection to block transcription. Total RNA was isolated at 0.5, 2, 3, and 4 h for β-globin/GM-CSF ARE assays (A) and 0.5, 1.5, 3, and 6 h for β-globin/c-fos ARE assays (B) and analyzed by Northern blot. GAPDH served as a loading control. mRNA half-lives were calculated from Northern blots and normalized against GAPDH levels. (C) Protein extracts were collected at 6 h after treatment with doxycycline (1 μg/ml) from cells that were transfected with the reporter plasmid and pTetOff and ...
Non-stop decay is a cellular mechanism of mRNA surveillance to detect mRNA molecules lacking a stop codon and prevent these mRNAs from translation. The non-stop decay pathway releases ribosomes that have reached the far 3 end of an mRNA and guides the mRNA to the exosome complex, or to RNase R in bacteria for selective degradation. In contrast to NMD, polypeptides do not release from the ribosome, and thus, NSD seems to involve mRNA decay factors distinct from NMD. Non-stop decay is a cellular pathway that identifies and degrades aberrant mRNA transcripts that do not contain a proper stop codons. Stop codons are signals in messenger RNA that signal for synthesis of proteins to end. Aberrant transcripts are identified during translation when the ribosome translates into the poly A tail at the 3 end of mRNA. A non-stop transcript can occur when point mutations damage the normal stop codon. Moreover, some transcriptions are more likely to preserve low scale of gene expression in a particular ...
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TY - JOUR. T1 - How Can Animal Disease Risks be Better Managed?. AU - Carpenter, Tim. AU - Rich, Karl M.. PY - 2012/8/1. Y1 - 2012/8/1. N2 - Livestock farming is imbued with a variety of disease-related risks. The threat of disease, and actions taken (or not taken) to mitigate it, can impact both the broader livestock sector and potentially society at large if the disease is what is termed zoonotic i.e. impacting both animal and human health alike. Understanding the nature of these risks is crucial to improve policymaking and requires multidisciplinary toolkits. In this article we identify various frameworks from economics and epidemiology to analyze the impact of animal disease risks in livestock environments. From this, we examine the policy responses implemented to better manage risk, and conclude by identifying the current gaps in the decision process related to risk and uncertainty, which is a reflection of imperfect knowledge. Recent advances in our modeling frameworks have helped ...
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Adenylate-uridylate-rich elements (AU-rich elements; AREs) are found in the 3 untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors, and cytokines. AREs are one of the most common determinants of RNA stability in mammalian cells. AREs are defined as a region with frequent adenine and uridine bases in a mRNA. They usually target the mRNA for rapid degradation. ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines, and transcription inhibitors. These observations suggest that AREs play a critical role in the regulation of gene transcription during cell growth and differentiation, and the immune response. AREs have been divided into three classes with different sequences. The best characterised adenylate uridylate (AU)-rich Elements have a core sequence of AUUUA within U-rich sequences (for example WWWU(AUUUA)UUUW where W is A or U). This lies within a 50-150 ...
In inflammation, the post-transcriptional regulation of transiently expressed genes provides a potential therapeutic target. Tristetraprolin (TTP) is of the factors regulating decay of cytokine mRNAs. The aim of the present ...
TY - GEN. T1 - Photoporation and cell transfection using a violet diode laser. AU - Paterson, L.. AU - Agate, B.. AU - Comrie, M.. AU - Ferguson, R.. AU - Lake, T. K.. AU - Morris, J. E.. AU - Carruthers, A. E.. AU - Brown, C. T.A.. AU - Sibbett, W.. AU - Bryant, P. E.. AU - Gunn-Moore, F.. AU - Riches, A. C.. AU - Dholakia, K.. PY - 2005/10/31. Y1 - 2005/10/31. N2 - Stable transfection of Chinese hamster ovary (CHO-K1) cells is achieved by photoporation with a violet diode laser. This represents the simplest method of laser-assisted cell poration reported to date.. AB - Stable transfection of Chinese hamster ovary (CHO-K1) cells is achieved by photoporation with a violet diode laser. This represents the simplest method of laser-assisted cell poration reported to date.. UR - http://www.scopus.com/inward/record.url?scp=27144453767&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=27144453767&partnerID=8YFLogxK. M3 - Conference contribution. AN - SCOPUS:27144453767. SN - ...
Pillar II capital buffers include risks that are not sufficiently captured under Pillar I capital requirements taking into account institution-specific factors such as business model, activities, size, risk profile and risk appetite, and stress testing results. DTIs are responsible for developing and implementing internal capital targets and developing strategies to achieve those internal targets. OSFIs approach to assessing the adequacy of Pillar II capital buffers established by DTIs is outlined in guideline E-19 Internal Capital Adequacy Assessment Process and guideline E-18 Stress Testing.. Capital buffers are built-up during normal times to provide an institution with additional flexibility in times of stress. As noted in a statement by the Superintendent on April 3, 2020, regarding measures taken to support the resilience of financial institutions, OSFI considers that measured declines in bank capital ratios are acceptable in the current circumstances and entirely consistent with the ...
Nahrungsmittelallergien sind Erkrankungen, die durch immunologisch vermittelte, entzündliche Reaktionen auf Nahrungsmittelproteine bei individuellen Personen zustande kommen. Es werden IgE-vermittelte
TY - JOUR. T1 - Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?. AU - Sigal, N. H.. AU - Dumont, F.. AU - Durette, P.. AU - Siekierka, John. AU - Peterson, L.. AU - Rich, D. H.. AU - Dunlap, B. E.. AU - Staruch, M. J.. AU - Melino, M. R.. AU - Koprak, S. L.. AU - Williams, D.. AU - Witzel, B.. AU - Pisano, J. M.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - In this report we have approached two questions relating to the mechanism of action of cyclosporin A (CsA). First, we address whether the major cytosolic protein for CsA, cyclophilin, is directly involved in mediating the immunosuppressive activity of this drug, and, in particular, whether inhibition of this proteins peptidyl-prolyl cis-trans isomerase (PPIase) activity results in inhibition of murine T cell activation. Second, we ask whether the nephrotoxicity observed with CsA is related to inhibition of PPIase-dependent pathways in cells other than lymphocytes. Using a series of 61 cyclosporin ...
Expression of IL17A and IL22 mRNA (Fig. 4 B), and frequencies of IL17A- and IL22-producing CD4 T or γδ T cells (Fig. 4, C and D) within peripheral LN or skin were found to be completely dependent on both IL23p19 and TNF signaling. Similarly, TNF mRNA levels within skin lesions were reduced in the absence of IL23, IL17A, and TNFR expression (Fig. 4 B). No impact was observed on numbers of TNF-producing cells at this site of inflammation (unpublished data), suggesting that other cell types, such as myeloid cells, constitute the source of this cytokine. Regarding IFN-γ production, both mRNA levels and CD4+ T cells proportions were comparable between groups (Fig. 4 B and not depicted).. Absence of TTP also leads to myeloid hyperplasia, characterized by increased proportions of F4/80+ macrophages and GR1+ neutrophils in the BM and the spleen (Taylor et al., 1996), accompanied by a slight reduction in B cell numbers in these lymphoid organs. This spontaneous granulocyte hyperplasia was recently ...
Sigma-Aldrich offers abstracts and full-text articles by [Sandrine Chamboredon, Delphine Ciais, Agnès Desroches-Castan, Pierre Savi, Françoise Bono, Jean-Jacques Feige, Nadia Cherradi].
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Die Entwicklung einer Lungenfibrose durch direkte radioaktive Strahleneinwirkung auf das periphere Lungengewebe konnte histo-pathologisch und funktionsanalytisch sowohl tierexperimentell [1, 8, 20,...
CFCA PAPER NO Property and financial matters upon the breakdown of de facto relationships Rachel Carson Reforms introduced in 2009 to the Family Law Act 1975 (Cth) have meant that most samesex
AU-rich element decayEdit. The presence of AU-rich elements in some mammalian mRNAs tends to destabilize those transcripts ... Chen, C.Y.A.; Shyu, A.B. (1995), "AU-rich elements: characterization and importance in mRNA degradation", Trends in Biochemical ... AU-rich elements also regulate the biosynthesis of proto-oncogenic transcription factors like c-Jun and c-Fos.[29] ... Rapid mRNA degradation via AU-rich elements is a critical mechanism for preventing the overproduction of potent cytokines such ...
... is a database of AU-rich elements (ARE) in vertebrate mRNA 3'-untranslated regions (UTRs). AU-rich elements are ... AU-rich elements Gruber, Andreas R; Fallmann Jörg; Kratochvill Franz; Kovarik Pavel; Hofacker Ivo L (Jan 2011). "AREsite: a ... database for the comprehensive investigation of AU-rich elements". Nucleic Acids Res. England. 39 (Database issue): D66-9. doi: ...
One group of elements in the 3'-UTR that can help destabilize an mRNA transcript are the AU-rich elements (AREs). These ... UTR contains many alternative AU-rich elements and polyadenylation signals. These cis- and trans-acting elements, along with ... The element that controls this process is called the CPE which is AU-rich and located in the 3'-UTR as well. The CPE generally ... In addition to containing MREs, the 3'-UTR also often contains AU-rich elements (AREs), which are 50 to 150 bp in length and ...
MicroRNA-223 selectively targets distinct populations of transcripts harboring AU-rich elements. More specifically, it was ...
A number of such elements have been called AU-rich elements (AREs). It is now known that AREs are binding sites for RNA-binding ... "Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU ... Bakheet T, Frevel M, Williams BR, Greer W, Khabar KS (January 2001). "ARED: human AU-rich element-containing mRNA database ... "Protein expression is increased by a class III AU-rich element and tethered CUG-BP1". Biochem. Biophys. Res. Commun. 347 (3): ...
2007). "Human and yeast zeta-crystallins bind AU-rich elements in RNA". Cell. Mol. Life Sci. 64 (11): 1419-27. doi:10.1007/ ...
Mammalian mRNAs contain AU-rich elements (AREs) within their three prime untranslated regions. In yeast, 3-prime-to-5-prime ... Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (November 2001). "AU ... 2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451-64. doi:10.1016/S0092-8674 ...
For example, miR16 contains a sequence complementary to the AU-rich element found in the 3'UTR of many unstable mRNAs, such as ... "Involvement of microRNA in AU-rich element-mediated mRNA instability". Cell. 120 (5): 623-34. doi:10.1016/j.cell.2004.12.038. ... Some of the G-rich pre-miRNAs can potentially adopt the G-quadruplex structure as an alternative to the canonical stem-loop ... These proteins have three highly positively charged regions, termed AT hooks, that bind the minor groove of AT-rich DNA ...
"The Herpesvirus saimiri small nuclear RNAs recruit AU-rich element-binding proteins but do not alter host AU-rich element- ... "The Herpesvirus saimiri small nuclear RNAs recruit AU-rich element-binding proteins but do not alter host AU-rich element- ... Fan XC, Myer VE, Steitz JA (October 1997). "AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation ...
This protein binds to AU rich elements in FOS and IL3/interleukin-3 mRNAs. Microarray analysis of GEO profiles were conducted ...
... is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory ... a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154-66. doi:10.1074/jbc. ...
This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. One of its best-known functions is ... Chen CY, Xu N, Shyu AB (2002). "Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization ... 2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol ... 2002). "Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the ...
Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA". J. Biol. Chem. 275 ( ... TTP binds to AU-rich elements (AREs) in the 3'-untranslated regions (UTRs) of the mRNAs of some cytokines and promotes their ... non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs". J. Biol. ... Lai WS, Stumpo DJ, Blackshear PJ (1990). "Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein". J ...
"A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements". EMBO J. 20 (5): 1134-43. doi: ... "Tristetraprolin and Its Family Members Can Promote the Cell-Free Deadenylation of AU-Rich Element-Containing mRNAs by Poly(A) ... 2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451-64. doi:10.1016/S0092-8674 ...
2002). "The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements". EMBO J. 21 (1-2): 165 ... 2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451-64. doi:10.1016/S0092-8674 ...
CCCH and CCHC zinc fingers bind to an AU-rich RNA element. Different from CCHH zinc figure, the shape of the protein is the ...
UTR of TNFα contains an AU-rich element (ARE). TNF is primarily produced as a 233-amino acid-long type II transmembrane protein ... Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF alpha/NF-kappa B signal ...
In the cytoplasm, the exosome interacts with AU rich element (ARE) binding proteins (e.g. KRSP and TTP), which can promote or ... Several proteins that stabilize or destabilize mRNA molecules through binding to AU-rich elements in the 3' untranslated region ... Lin, WJ; Duffy, A; Chen, CY (2007). "Localization of AU-rich element-containing mRNA in cytoplasmic granules containing exosome ... 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451-64. doi:10.1016/S0092-8674 ...
HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half- ... Wang X, Tanaka Hall TM (2001). "Structural basis for recognition of AU-rich element RNA by the HuD protein". Nat. Struct. Biol ... 2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol ...
This article describes a work or element of fiction in a primarily in-universe style. Please help rewrite it to explain the ... Alternate forms of naquadah include liquid naquadah, used to power Goa'uld staff weapons,[9] and heavy liquid naquadah, used to ... is rich in neutronium, which leads it to be targeted by the Replicators.[18] The nanite Asurans are also based on neutronium, ... Fictional materials and elements [edit]. *Hoffan drug A drug made by the Hoffans, which prevents the individual from being fed ...
Pioli PA, Hamilton BJ, Connolly JE, Brewer G, Rigby WF (September 2002). "Lactate dehydrogenase is an AU-rich element-binding ... Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a protein ... "Entrez Gene: HNRPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)". Mazan-Mamczarz K ... AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue". Mol. Carcinog. 28 (2): 76-83. ...
Pioli PA, Hamilton BJ, Connolly JE, Brewer G, Rigby WF (September 2002). "Lactate dehydrogenase is an AU-rich element-binding ...
The presence of AU-rich elements in some mammalian mRNAs tends to destabilize those transcripts through the action of cellular ... Rapid mRNA degradation via AU-rich elements is a critical mechanism for preventing the overproduction of potent cytokines such ... AU-rich elements also regulate the biosynthesis of proto-oncogenic transcription factors like c-Jun and c-Fos. Eukaryotic ... "AU-rich elements: characterization and importance in mRNA degradation", Trends in Biochemical Sciences, 20 (11): 465-470, doi: ...
2006). "Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay". Mol. Cell. Biol. 26 ( ... Far upstream element-binding protein 2 is a protein that in humans is encoded by the KHSRP gene. GRCh38: Ensembl release 89: ... 2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451-64. doi:10.1016/S0092-8674 ... Davis-Smyth T, Duncan RC, Zheng T, Michelotti G, Levens D (Jan 1997). "The far upstream element-binding proteins comprise an ...
... functions in AU-rich element-mediated mRNA decay". Molecular and Cellular Biology. 28 (17): 5223-37. doi:10.1128/MCB.00431-08. ...
Alcoser SY, Hara M, Bell GI, Ehrmann DA (2004). "Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal ...
Eaton, Richard M. (1993). The Rise of Islam and the Bengal Frontier, 1204-1760. University of California. ISBN 978-0-520-20507- ... Chatterji, SK (1921). "Bengali Phonetics". Bulletin of the School of Oriental and African Studies. 2: 1. doi:10.1017/ ... Language is an important element of Bengali identity and binds together a culturally diverse region. ... Volume 18 of London Oriental and African Language Library. John Benjamins Publishing. ISBN 9027273138. ...
HuR binds to AU-rich elements which are scattered throughout the 3' UTR and are thought to be negative regulators of transcript ... Café-au-lait spots are the most common sign of NF1, but other symptoms include lisch nodules, cutaneous neurofibromas, ... Although no core promoter element has been found, consensus binding sequences have been identified in the 5' UTR for several ... Aberrant splicing may also occur due to mutations within a splicing regulatory element. Intronic mutations that fall outside of ...
Architectural Elements, LLC. Bucher. Wellington*. Lykos. 2(d). Refusal Affirmed. DESIGNER DOORS BY AUTUMNWOOD (and design) (" ... 8,946,768 to RICHARD BLANCHARD of Los Altos, CA for SYSTEMS, CIRCUITS, DEVICES, AND METHODS WITH BIDIRECTIONAL BIPOLAR ... 8,945,075 to SAIED SABETI of Hocking, AU for MEDICAL DEVICE appearing in the Official Gazette of February 03, 2015 should be ... 8,945,204 to DAVID HARTLEY of Wannanup, AU for FENESTRATED STENT GRAFTS appearing in the Official Gazette of February 03, 2015 ...
AU-rich elements Pillars link to original 1986 Cell publication discovering AU-rich elements mRNA Translational blockade by AU- ... rich elements Brief introduction to mRNA regulatory elements ARED: AU-rich element database Transterm page for AU-Rich Element ... Adenylate-uridylate-rich elements (AU-rich elements; AREs) are found in the 3 untranslated region (UTR) of many messenger RNAs ... The best characterised adenylate uridylate (AU)-rich Elements have a core sequence of AUUUA within U-rich sequences (for ...
Involvement of microRNA in AU-rich element-mediated mRNA instability.. Jing Q1, Huang S, Guth S, Zarubin T, Motoyama A, Chen J ... AU-rich elements (AREs) in the 3 untranslated region (UTR) of unstable mRNAs dictate their degradation. An RNAi-based screen ...
AU-Rich Elements Regulate Drosophila Gene Expression Fatima Cairrao, Anason S. Halees, Khalid S. A. Khabar, Dominique Morello, ... AU-Rich Elements Regulate Drosophila Gene Expression Fatima Cairrao, Anason S. Halees, Khalid S. A. Khabar, Dominique Morello, ... AU-Rich Elements Regulate Drosophila Gene Expression Fatima Cairrao, Anason S. Halees, Khalid S. A. Khabar, Dominique Morello, ... AU-Rich Elements Regulate Drosophila Gene Expression Message Subject (Your Name) has forwarded a page to you from Molecular and ...
Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can ... zinc finger proteins has recently been shown to promote the turnover of certain mRNAs containing class II AU-rich elements ( ...
AU-rich element RNA binding protein 1, 37kDa)), Authors: Carsten Sekulla, Bogusz Trojanowicz, Cuong Hoang-Vu. Published in: ... heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA-binding protein 1, 37kD). ... HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)). Written. 2009-11. Carsten ... Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element.. ...
The Protein Zfand5 Binds and Stabilizes mRNAs with AU-rich Elements in Their 3 prime Untranslated Regions ...
The most common cis element responsible for rapid mRNA decay in mammalian cells is the AU-rich element (ARE) present within the ... Tethering KSRP, a Decay-Promoting AU-Rich Element-Binding Protein, to mRNAs Elicits mRNA Decay. Chu-Fang Chou, Alok Mulky, ... Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element. Genes Dev. 13: ... AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20:465-470. ...
Helfer, Stephanie; Schott, Johanna; Stoecklin, Georg; Förstemann, Klaus (2012): AU-rich element-mediated mRNA decay can occur ... AU-rich elements (AREs) are regulatory sequences located in the 3 untranslated region of many short-lived mRNAs. AREs are ... Thus, this sequence cannot serve as link between the miRNA and the AU-rich element mediated silencing pathways. Taken together ... Furthermore, the Drosophila miRNA originally proposed to recognize AU-rich elements, miR-289, is not detectably expressed in ...
AU-Rich Element RNA Binding Protein 1, 37kDa) (HNRNPD) Protein (His tag). Spezies: Human. Quelle: Escherichia coli (E. coli). ... AU-Rich Element RNA Binding Protein 1,... Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, ... AU-Rich Element RNA Binding Protein 1, 37kDa) Protein * 115 anti-Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA ... AU-Rich Element RNA Binding Protein 1, 37kDa) (HNRNPD) Hintergrund Binds with high affinity to RNA molecules that contain AU- ...
Although SLC4A4 is normally devoid of AU-rich elements (AREs), a 3′ UTR motif that mediates post-transcriptional control of a ... AU-rich elements are among the most important regulatory elements that post-transcriptionally control the expression of many ... Sequence variations affecting AU-rich element function and disease. Front Biosci (Landmark Ed). 2012;17:1846-60.View Article ... Hallmarks of cancer and AU-rich elements. Wiley Interdiscip Rev RNA. 2017;8:e1368.View ArticleGoogle Scholar. ...
Thus, the presence of adenylate- and uridylate-rich (AU-rich) elements (AREs) has been described in the 3-untranslated regions ... Thus, the presence of adenylate- and uridylate-rich (AU-rich) elements (AREs) has been described in the 3-untranslated regions ... Thus, the presence of adenylate- and uridylate-rich (AU-rich) elements (AREs) has been described in the 3-untranslated regions ... Thus, the presence of adenylate- and uridylate-rich (AU-rich) elements (AREs) has been described in the 3-untranslated regions ...
AU-rich element decayEdit. The presence of AU-rich elements in some mammalian mRNAs tends to destabilize those transcripts ... Chen, C.Y.A.; Shyu, A.B. (1995), "AU-rich elements: characterization and importance in mRNA degradation", Trends in Biochemical ... AU-rich elements also regulate the biosynthesis of proto-oncogenic transcription factors like c-Jun and c-Fos.[29] ... Rapid mRNA degradation via AU-rich elements is a critical mechanism for preventing the overproduction of potent cytokines such ...
AU-rich element. BDGP. Berkeley Drosophila genome project. BSED. binding site enrichment detection ... H.J. Bussemaker, H. Li, E.D. Siggia: Regulatory element detection using correlation with expression, Nat. Genet. 27, 167-171 ( ...
AU-rich elements (AREs) found in the 3′ untranslated region are the best characterized signals that target a variety of short- ... AU-rich elements (AREs) located in the 3′ untranslated region target the mRNAs encoding many protooncoproteins, cytokines, and ...
AU-rich elements (AREs) in 3-untranslated regions of mRNAs confer instability. They target mRNAs for rapid deadenylation and ... AU-rich elements (AREs) in 3-untranslated regions of mRNAs confer instability. They target mRNAs for rapid deadenylation and ... p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements ... p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements ...
T1 - Functionally Different AU- and G-rich cis-Elements Confer Developmentally Regulated mRNA Stability in Trypanosoma cruzi by ... Functionally Different AU- and G-rich cis-Elements Confer Developmentally Regulated mRNA Stability in Trypanosoma cruzi by ... Functionally Different AU- and G-rich cis-Elements Confer Developmentally Regulated mRNA Stability in Trypanosoma cruzi by ... Functionally Different AU- and G-rich cis-Elements Confer Developmentally Regulated mRNA Stability in Trypanosoma cruzi by ...
Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystemRNA elements rich in adenine ... The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. Mukherjee D, et al. EMBO J, ... AU-rich element binding IBA Inferred from Biological aspect of Ancestor. more info ... The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements, possibly by direct binding of ...
The AU-rich element (ARE) is an important instability determinant for a large number of early-response-gene mRNAs. AREs also ... The AU-rich element (ARE) is an important instability determinant for a large number of early-response-gene mRNAs. AREs also ... Identification of a novel AU-rich-element-binding protein which is related to AUF1 ... Identification of a novel AU-rich-element-binding protein which is related to AUF1 ...
The mRNAs regulated by p38 share common AU-rich elements (ARE) present in their 3-untranslated regions. AREs act as mRNA ... The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation ... The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation ... The mRNAs regulated by p38 share common AU-rich elements (ARE) present in their 3-untranslated regions. AREs act as mRNA ...
AU-rich elements. ATP. adenosine 5-triphosphate. BDH2. 3-hydroxybutyrate dehydrogenase, type 2 ...
AU-rich element. Introduction. Metabolites of arachadonic acid participate in normal and aberrant growth responses, including ... The Translational Silencer TIA-1 Binds the COX-2 AU-Rich Element.. Best characterized for their ability to mediate rapid mRNA ... AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors. Biochem. Soc. ... mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor ...
AREsite: a database for the comprehensive investigation of AU-rich elements. Nucleic Acids Res. 39(Database issue): D66-D69. ... TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev. 21: 719-735. ... AU-rich element-mediated mRNA decay can occur independently of the miRNA machinery in mouse embryonic fibroblasts and ... Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated ...
AU-rich element. Cyto. cytoplasmic protein extracts. eIF2. eukaryotic translation initiation factor 2. GCN2. general control ... Nutritional control of mRNA stability is mediated by a conserved AU-rich element that binds the cytoplasmic shuttling protein ... Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis ... binding of tristetraprolin-related zinc finger proteins to AU-rich elements and destabilization of mRNA. J. Biol. Chem. 275: ...
1997) The Elav-like RNA binding proteins bind to AU-rich elements and to the poly(A) of mRNA. Nucleic Acids Res 25:3564-3569. ... 1995) AU-rich elements: characterization and importance in mRNA degradation. Trends Biol Sci 20:465-470. ... 1998) RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J 17:3461-3470. ... These U-rich elements were originally described by Shaw and Kamen (1986), who found that they direct the rapid turnover of mRNA ...
  • AREsite-a database for ARE containing genes-has recently been developed with the aim to provide detailed bioinformatic characterization of AU-rich elements. (wikipedia.org)
  • Lots of genes, including inflammatory cytokines and cancer-causing oncogenes, have these AU-rich elements built in. (scripps.edu)
  • To understand the mechanisms regulating COX-2 expression, we examined its posttranscriptional regulation mediated through the AU-rich element (ARE) within the COX-2 mRNA 3′-untranslated region (3′UTR). (rupress.org)
  • We previously identified an AU-rich element (ARE) within the 3′ untranslated region (3′UTR) of COX-2 mRNA that confers posttranscriptional regulation by controlling both mRNA decay and protein translation ( 4 , 5 ). (rupress.org)
  • By targeting the Rev response element of human immunodeficiency virus type 1 by using Rev-KSRP fusion protein, we degraded viral mRNA, resulting in a dramatic reduction of viral replication. (asm.org)
  • Professor Richard Eccleston is a political scientist and the founding Director of the Institute for the Study of Social Change who specialises in tax and budget politics. (edu.au)
  • Richard Eccleston is Professor of Political Science and founding Director of the Institute for the Study of Social Change at the University of Tasmania. (edu.au)
  • Exons 3-6 encode the rest of the first RBD, the N-terminal half of the second RBD, the C-terminal half of the second RBD and the glutamine rich region, respectively. (atlasgeneticsoncology.org)
  • The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets. (nih.gov)
  • We have developed methods which enable us to identify en masse , in vivo targets of RBPs such as HuR from cell lines and now for the first time, solid tissues as well. (aacrjournals.org)
  • This technique, in which no cross linking is used, allows one to en masse identify different in vivo mRNA targets which different RBPs interact with. (aacrjournals.org)
  • To assess whether structural elements of ARE2197 could explain this unique binding ability, we performed whole-transcript SHAPE-MaP (selective 2' hydroxyl acylation by primer extension-mutational profiling) of the full-length mLHR mRNA. (sigmaaldrich.com)
  • The structure of the third double-stranded RNA-binding domain (dsRBD) of Loqs has been solved, and specific structural elements have been defined that interact with Dcr1. (sdbonline.org)
  • Thus, ARE and GRE are functionally different cis-elements, which might regulate mucin expression throughout the parasite life cycle. (elsevier.com)
  • The ability of this cis-acting mRNA element to regulate COX-2 protein levels and associated prostaglandin synthesis was observed in cells maintaining low to undetectable COX-2 levels ( 4 ). (rupress.org)