An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
Analogs and derivatives of atropine.
One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3....) that are characterized by their cellular actions, pharmacology, and molecular biology.
Compounds containing the hexamethylenebis(trimethylammonium) cation. Members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Various salts of a quaternary ammonium oxime that reconstitute inactivated acetylcholinesterase, especially at the neuromuscular junction, and may cause neuromuscular blockade. They are used as antidotes to organophosphorus poisoning as chlorides, iodides, methanesulfonates (mesylates), or other salts.
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.
The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.
The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
Agents affecting the function of, or mimicking the actions of, the autonomic nervous system and thereby having an effect on such processes as respiration, circulation, digestion, body temperature regulation, certain endocrine gland secretions, etc.
Use of electric potential or currents to elicit biological responses.
Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.
A group of compounds that are derivatives of beta-methylacetylcholine (methacholine).
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.
Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate.
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. They are an important component of therapy in agricultural, industrial, and military poisonings by organophosphates and sulfonates.
Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.
A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.
Agents counteracting or neutralizing the action of POISONS.
An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.
The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
The motor activity of the GASTROINTESTINAL TRACT.
Nerve fibers liberating acetylcholine at the synapse after an impulse.
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Bethanechol compounds are drugs that stimulate the muscarinic receptors in the body, particularly in the smooth muscles of the bladder and the pupils of the eye, to increase urine flow and dilate the pupils, respectively.
Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
A non-hydrolyzed muscarinic agonist used as a research tool.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The discharge of saliva from the SALIVARY GLANDS that keeps the mouth tissues moist and aids in digestion.
Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
Drugs administered before an anesthetic to decrease a patient's anxiety and control the effects of that anesthetic.
A high-affinity muscarinic antagonist commonly used as a tool in animal and tissue studies.
Drugs that bind to and activate cholinergic receptors.
An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.
Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists.
Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery.
A toxic alkaloid found in Amanita muscaria (fly fungus) and other fungi of the Inocybe species. It is the first parasympathomimetic substance ever studied and causes profound parasympathetic activation that may end in convulsions and death. The specific antidote is atropine.
An organophosphorus insecticide that inhibits ACETYLCHOLINESTERASE.
N-methyl-8-azabicyclo[3.2.1]octanes best known for the ones found in PLANTS.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
That phase of a muscle twitch during which a muscle returns to a resting position.
An organophosphorus compound that inhibits cholinesterase. It causes seizures and has been used as a chemical warfare agent.
Bretylium compounds are a class of drugs used in the medical field to treat certain types of heart arrhythmias by blocking the influx of calcium ions into cardiac cells.
A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
A subclass of muscarinic receptor that mediates cholinergic-induced contraction in a variety of SMOOTH MUSCLES.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).
An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)
The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.
A histamine H2 receptor antagonist that is used as an anti-ulcer agent.
A selective nicotinic cholinergic agonist used as a research tool. DMPP activates nicotinic receptors in autonomic ganglia but has little effect at the neuromuscular junction.
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
A specific subtype of muscarinic receptor found in the lower BRAIN, the HEART and in SMOOTH MUSCLE-containing organs. Although present in smooth muscle the M2 muscarinic receptor appears not to be involved in contractile responses.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
The superior portion of the body of the stomach above the level of the cardiac notch.
A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.
A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.
A specific subtype of muscarinic receptor that has a high affinity for the drug PIRENZEPINE. It is found in the peripheral GANGLIA where it signals a variety of physiological functions such as GASTRIC ACID secretion and BRONCHOCONSTRICTION. This subtype of muscarinic receptor is also found in neuronal tissues including the CEREBRAL CORTEX and HIPPOCAMPUS where it mediates the process of MEMORY and LEARNING.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
The major nerves supplying sympathetic innervation to the abdomen. The greater, lesser, and lowest (or smallest) splanchnic nerves are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses. The lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia.
Alkaloids, mainly tropanes, elaborated by plants of the family Solanaceae, including Atropa, Hyoscyamus, Mandragora, Nicotiana, Solanum, etc. Some act as cholinergic antagonists; most are very toxic; many are used medicinally.
Benzilates are esters of benzilic acid that are used as preservatives in medical products to prevent microbial growth.
The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.
A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.

Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus. (1/2794)

The effects of metrifonate, a second generation cholinesterase inhibitor, were examined on CA1 pyramidal neurons from hippocampal slices of young and aging rabbits using current-clamp, intracellular recording techniques. Bath perfusion of metrifonate (10-200 microM) dose-dependently decreased both postburst afterhyperpolarization (AHP) and spike frequency adaptation (accommodation) in neurons from young and aging rabbits (AHP: p < 0.002, young; p < 0.050, aging; accommodation: p < 0.024, young; p < 0.001, aging). These reductions were mediated by muscarinic cholinergic transmission, because they were blocked by addition of atropine (1 microM) to the perfusate. The effects of chronic metrifonate treatment (12 mg/kg for 3 weeks) on CA1 neurons of aging rabbits were also examined ex vivo. Neurons from aging rabbits chronically treated with metrifonate had significantly reduced spike frequency accommodation, compared with vehicle-treated rabbits. Chronic metrifonate treatment did not result in a desensitization to metrifonate ex vivo, because bath perfusion of metrifonate (50 microM) significantly decreased the AHP and accommodation in neurons from both chronically metrifonate- and vehicle-treated aging rabbits. We propose that the facilitating effect of chronic metrifonate treatment on acquisition of hippocampus-dependent tasks such as trace eyeblink conditioning by aging subjects may be caused by this increased excitability of CA1 pyramidal neurons.  (+info)

Indirect evidence for cholinergic inhibition of intestinal bicarbonate absorption in humans. (2/2794)

BACKGROUND: The aim of the study was to test the hypothesis that in the fasting state, proximal intestinal HCO3- absorption, which depends on villus Na+/H+ exchanger activity, is tonically inhibited by a cholinergic atropine sensitive mechanism. SUBJECTS: The experiments were performed in 34 healthy volunteers and in eight patients with intestinal villus atrophy. METHODS: HCO3- absorption was measured with a modified triple lumen perfusion technique in the distal duodenum, the most proximal portion of the small intestine. The study was designed to compensate for the inhibitory effects of atropine on intestinal motor activity. RESULTS: Atropine had three effects on HCO3- transport: it reduced HCO3- concentration at the proximal aspiration site, it displaced the relation between HCO3- concentration and HCO3- absorption to the left, and it induced a significant acidification of the perfusate at the distal aspiration site. The magnitude of the stimulatory effect on HCO3- absorption was similar to the difference between patients with intestinal villus atrophy and healthy controls. CONCLUSION: The data suggest that, in the fasting state, duodenal HCO3- absorption, which depends on villus Na+/H+ exchanger activity, may be tonically inhibited by an atropine sensitive cholinergic mechanism.  (+info)

Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo. (3/2794)

In five fasting, conscious dogs, we compared the prokinetic action of two selective 5-hydroxytryptamine-4 (5-HT4) receptor agonists with low affinity for 5-HT3 receptors ML10302 (2-piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate) and SR59768 (2-[(3S)-3-hydroxypiperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate) in the duodenum and jejunum, using cisapride as a reference compound. Heart rate and rate-corrected QT (QTc) also were monitored to assess whether or not the cardiac effects of cisapride are shared by other 5-HT4 receptor agonists. Both ML10302 and SR59768 dose-dependently stimulated spike activity in the duodenum with similar potencies (dose range, 3-300 nmol/kg i.v.; ED50 values: 24 and 23 nmol/kg i.v., respectively), mimicking the effect of cisapride (30-3000 nmol/kg i.v.). The maximal effect was achieved with the dose of 100 nmol/kg i.v. for both compounds. Similar findings were obtained in the jejunum. Atropine and GR125487 (1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl-methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate, selective 5-HT4 receptor antagonist), at doses having no effect per se, antagonized intestinal prokinesia by maximal doses of ML10302 and SR59768. Neither ML10302 nor SR59768 had any effect on heart rate or QTc at any of the doses tested, whereas cisapride, at the highest dose (3000 nmol/kg), induced tachycardia and lengthened the QTC (p <.01). In conclusion, ML10302 and SR59768 share with cisapride a similar prokinetic action in the canine duodenum and jejunum in vivo. This effect is mediated by pathways involving activation of 5-HT4 and muscarinic receptors. Unlike cisapride, which induces tachycardia and prolongs the QTc by a mechanism probably unrelated to 5-HT4 receptor activation, ML10302 and SR59768 are devoid of cardiac effects in this model.  (+info)

Neuroregulation by vasoactive intestinal peptide (VIP) of mucus secretion in ferret trachea: activation of BK(Ca) channels and inhibition of neurotransmitter release. (4/2794)

1. The aims of this study were to determine: (1) whether vasoactive intestinal peptide (VIP) regulates cholinergic and 'sensory-efferent' (tachykininergic) 35SO4 labelled mucus output in ferret trachea in vitro, using a VIP antibody, (2) the class of potassium (K+) channel involved in VIP-regulation of cholinergic neural secretion using glibenclamide (an ATP-sensitive K+ (K(ATP)) channel inhibitor), iberiotoxin (a large conductance calcium activated K+ (BK(ca)) channel blocker), and apamin (a small conductance K(ca) (SK(ca)) channel blocker), and (3) the effect of VIP on cholinergic neurotransmission using [3H]-choline overflow as a marker for acetylcholine (ACh) release. 2. Exogenous VIP (1 and 10 microM) alone increased 35SO4 output by up to 53% above baseline, but suppressed (by up to 80% at 1 microM) cholinergic and tachykininergic neural secretion without altering secretion induced by ACh or substance P (1 microM each). Endogenous VIP accounted for the minor increase in non-adrenergic, non-cholinergic (NANC), non-tachykininergic neural secretion, which was compatible with the secretory response of exogenous VIP. 3. Iberiotoxin (3 microM), but not apamin (1 microM) or glibenclamide (0.1 microM), reversed the inhibition by VIP (10 nM) of cholinergic neural secretion. 4. Both endogenous VIP (by use of the VIP antibody; 1:500 dilution) and exogenous VIP (0.1 microM), the latter by 34%, inhibited ACh release from cholinergic nerve terminals and this suppression was completely reversed by iberiotoxin (0.1 microM). 5. We conclude that, in ferret trachea in vitro, endogenous VIP has dual activity whereby its small direct stimulatory action on mucus secretion is secondary to its marked regulation of cholinergic and tachykininergic neurogenic mucus secretion. Regulation is via inhibition of neurotransmitter release, consequent upon opening of BK(Ca) channels. In the context of neurogenic mucus secretion, we propose that VIP joins NO as a neurotransmitter of i-NANC nerves in ferret trachea.  (+info)

Anaphylactic bronchoconstriction in BP2 mice: interactions between serotonin and acetylcholine. (5/2794)

1. Immunized BP2 mice developed an acute bronchoconstriction in vivo and airway muscle contraction in vitro in response to ovalbumin (OA) and these contractions were dose dependent. 2. Methysergide or atropine inhibited OA-induced bronchoconstriction in vivo and airway muscle contraction in vitro. 3. Neostigmine potentiated the OA-induced bronchoconstriction in vivo and airway muscle contraction in vitro of BP2 mice. This potentiation was markedly reduced by the administration of methysergide or atropine and when the two antagonists were administered together, the responses were completely inhibited. 4. Neostigmine also potentiated the serotonin (5-HT)- and acetylcholine (ACh)-induced bronchoconstriction and this potentiation was significantly reversed by atropine. 5. These results indicate that OA provokes a bronchoconstriction in immunized BP2 mice by stimulating the release of 5-HT, which in turn acts via the cholinergic mediator, ACh.  (+info)

Mixed agonist-antagonist properties of clozapine at different human cloned muscarinic receptor subtypes expressed in Chinese hamster ovary cells. (6/2794)

We recently reported that clozapine behaves as a partial agonist at the cloned human m4 muscarinic receptor subtype. In the present study, we investigated whether the drug could elicit similar effects at the cloned human m1, m2, and m3 muscarinic receptor subtypes expressed in the Chinese hamster ovary (CHO) cells. Clozapine elicited a concentration-dependent stimulation of [3H]inositol phosphates accumulation in CHO cells expressing either the m1 or the m3 receptor subtype. Moreover, clozapine inhibited forskolin-stimulated cyclic AMP accumulation and enhanced [35S] GTP gamma S binding to membrane G proteins in CHO cells expressing the m2 receptor. These agonist effects of clozapine were antagonized by atropine. The intrinsic activity of clozapine was lower than that of the full cholinergic agonist carbachol, and, when the compounds were combined, clozapine potently reduced the receptor responses to carbachol. These data indicate that clozapine behaves as a partial agonist at different muscarinic receptor subtypes and may provide new hints for understanding the receptor mechanisms underlying the antipsychotic efficacy of the drug.  (+info)

Wavelet transform to quantify heart rate variability and to assess its instantaneous changes. (7/2794)

Heart rate variability is a recognized parameter for assessing autonomous nervous system activity. Fourier transform, the most commonly used method to analyze variability, does not offer an easy assessment of its dynamics because of limitations inherent in its stationary hypothesis. Conversely, wavelet transform allows analysis of nonstationary signals. We compared the respective yields of Fourier and wavelet transforms in analyzing heart rate variability during dynamic changes in autonomous nervous system balance induced by atropine and propranolol. Fourier and wavelet transforms were applied to sequences of heart rate intervals in six subjects receiving increasing doses of atropine and propranolol. At the lowest doses of atropine administered, heart rate variability increased, followed by a progressive decrease with higher doses. With the first dose of propranolol, there was a significant increase in heart rate variability, which progressively disappeared after the last dose. Wavelet transform gave significantly better quantitative analysis of heart rate variability than did Fourier transform during autonomous nervous system adaptations induced by both agents and provided novel temporally localized information.  (+info)

Assessment of cardiac sympathetic regulation by respiratory-related arterial pressure variability in the rat. (8/2794)

1. Mechanical ventilation evokes a corresponding arterial pressure variability (APV) which is decreased by beta-adrenoceptor antagonism. Therefore, in this study we set out to determine whether the respiratory-related APV can be used to assess cardiac sympathetic tone. 2. Computer-generated broad-band mechanical ventilation (0-3 Hz) was applied to Sprague-Dawley rats that had been anaesthetized with ketamine and paralysed with pancuronium. APV and its relationship to lung volume variability (LVV-APV) was systematically quantified with auto- or cross-spectral frequency domain analysis. 3. APV and LVV-APV transfer magnitudes between 0.5 and 1.5 Hz showed dose-dependent suppression by propranolol from 0.01 to 1 mg kg-1, while the static value of arterial pressure remained unchanged. Stroke volume variability, assessed by the use of a pulse contour method, exhibited a similar pattern of suppression by propranolol. In contrast, heart rate variability was not lowered with propranolol. 4. The effect of propranolol on respiratory-related APV persisted even in the presence of combined alpha-adrenoceptor and muscarinic receptor blockade by phentolamine and atropine. 5. The frequency range of 0.5-1.0 Hz was optimal for LVV-APV transfer magnitude to correlate with cardiac sympathetic tone. 6. We conclude that respiratory-related APV may provide a valid assessment of cardiac sympathetic regulation which is independent of parasympathetic and vascular sympathetic influences in ketamine-anaesthetized and positive pressure-ventilated rats.  (+info)

Atropine is a medication that is used to treat a variety of conditions, including bradycardia (slow heart rate), poisoning by certain drugs or toxins, and certain types of eye surgery. It is also used to treat symptoms of certain medical conditions, such as motion sickness and irritable bowel syndrome. Atropine works by blocking the action of acetylcholine, a neurotransmitter that is involved in many bodily functions, including muscle contractions, heart rate, and digestion. This can cause a number of side effects, including dry mouth, blurred vision, and difficulty urinating. Atropine is available in a variety of forms, including tablets, injections, and eye drops. It is important to follow the instructions of your healthcare provider when taking atropine, as the dosage and duration of treatment will depend on the specific condition being treated.

Atropine derivatives are a group of drugs that are derived from the alkaloid atropine, which is found in the plant Atropa belladonna. Atropine is a potent anticholinergic drug that blocks the action of acetylcholine, a neurotransmitter that plays a key role in many bodily functions, including muscle contraction, digestion, and the regulation of heart rate and blood pressure. Atropine derivatives are used to treat a variety of conditions, including motion sickness, bradycardia (slow heart rate), and certain types of poisoning. They are also used as a medication to dilate the pupils of the eye and to treat certain types of glaucoma. Some common examples of atropine derivatives include atropine sulfate, diphenhydramine, and scopolamine. Atropine derivatives can have a number of side effects, including dry mouth, blurred vision, dizziness, and confusion. They can also cause more serious side effects, such as arrhythmias (irregular heartbeats) and delirium. As with any medication, it is important to use atropine derivatives only under the guidance of a healthcare professional.

Receptors, Muscarinic are a type of cell surface receptors that are activated by the neurotransmitter acetylcholine. They are found in various tissues throughout the body, including the heart, lungs, digestive system, and central nervous system. There are five subtypes of muscarinic receptors, designated M1 through M5, each with different properties and functions. Activation of muscarinic receptors can produce a wide range of effects, including contraction of smooth muscle, stimulation of glandular secretion, and modulation of neurotransmitter release. In the medical field, muscarinic receptors are important targets for the treatment of various conditions, including asthma, irritable bowel syndrome, and certain types of heart disease. Drugs that interact with muscarinic receptors are often referred to as muscarinic agonists or antagonists, depending on whether they stimulate or block the activity of the receptors.

Hexamethonium compounds are a class of drugs that are used in the medical field as muscle relaxants. They work by blocking the action of acetylcholine, a neurotransmitter that triggers muscle contractions. This results in a decrease in muscle tone and relaxation of the muscles. Hexamethonium compounds are often used to treat conditions such as muscle spasms, urinary retention, and certain types of pain. They are also used as a diagnostic tool to test the function of the autonomic nervous system. However, hexamethonium compounds can have serious side effects, including dry mouth, blurred vision, dizziness, and difficulty breathing. They can also cause a condition called malignant hyperthermia, which is a potentially life-threatening reaction to certain anesthetic drugs. As a result, the use of hexamethonium compounds is generally reserved for cases where other treatments are not effective or are not available. They are also used with caution in patients with certain medical conditions, such as heart disease or respiratory problems.

Acetylcholine is a neurotransmitter that plays a crucial role in the transmission of signals between neurons in the nervous system. It is synthesized from the amino acid choline and is stored in vesicles within nerve cells. When an electrical signal reaches the end of a nerve cell, it triggers the release of acetylcholine into the synaptic cleft, the small gap between the nerve cell and the next cell it communicates with. Acetylcholine then binds to receptors on the surface of the receiving cell, causing a change in its electrical activity. Acetylcholine is involved in a wide range of bodily functions, including muscle movement, memory, and learning. It is also important for the regulation of the autonomic nervous system, which controls involuntary bodily functions such as heart rate and digestion. In the medical field, acetylcholine is used as a diagnostic tool to study the function of the nervous system, particularly in conditions such as Alzheimer's disease and myasthenia gravis. It is also used as a therapeutic agent in the treatment of certain conditions, such as glaucoma and myasthenia gravis, by increasing the activity of the affected nerves.

Pralidoxime compounds are a class of drugs used in the treatment of organophosphate poisoning. Organophosphate poisoning occurs when a person ingests or comes into contact with a chemical compound containing a phosphorus atom bonded to an oxygen atom, which inhibits the activity of an enzyme called acetylcholinesterase. This leads to an accumulation of acetylcholine in the body, which can cause symptoms such as muscle twitching, difficulty breathing, and even death. Pralidoxime compounds work by restoring the activity of acetylcholinesterase by chelating with the phosphorylated enzyme, allowing it to break down acetylcholine and return to its normal function. This helps to reverse the symptoms of organophosphate poisoning and prevent further damage to the body. Pralidoxime compounds are typically administered intravenously or intramuscularly, and may be given in combination with atropine, another medication used to treat organophosphate poisoning. It is important to note that pralidoxime compounds are not effective for all types of organophosphate poisoning, and their use should be determined by a healthcare professional based on the specific circumstances of the poisoning.

Physostigmine is a medication that is used to treat a variety of conditions, including glaucoma, myasthenia gravis, and Alzheimer's disease. It is a natural alkaloid that is derived from the plant Physostigma venenosum, which is found in the rainforests of Southeast Asia. Physostigmine works by increasing the activity of the neurotransmitter acetylcholine in the brain and muscles, which can help to improve muscle strength and coordination, as well as improve memory and cognitive function. It is usually administered as an injection or a tablet, and it can cause side effects such as nausea, vomiting, and dizziness.

Carbachol is a medication that is used in the medical field to treat certain conditions such as glaucoma, irritable bowel syndrome, and urinary incontinence. It is a cholinergic agonist, which means that it works by stimulating the action of a neurotransmitter called acetylcholine in the body. Acetylcholine is involved in a wide range of bodily functions, including muscle contraction, digestion, and the regulation of the heart rate and blood pressure. By stimulating the action of acetylcholine, carbachol can help to relax muscles, increase the production of digestive juices, and slow down the heart rate and blood pressure. It is usually administered as an eye drop for glaucoma, as a suppository for irritable bowel syndrome, or as an injection for urinary incontinence.

Pirenzepine is a medication that is used to treat symptoms of peptic ulcers, such as stomach pain and heartburn. It works by blocking the action of a chemical called acetylcholine, which helps to relax the muscles in the stomach and intestines. This can help to reduce the amount of acid that is produced in the stomach, which can help to relieve symptoms of peptic ulcers. Pirenzepine is available in both tablet and capsule form and is usually taken once or twice a day, with or without food. It is important to follow the instructions of your healthcare provider when taking pirenzepine, as it can cause side effects such as dizziness, headache, and constipation.

Neostigmine is a medication that is used to treat certain muscle disorders, such as myasthenia gravis, and to reverse the effects of certain medications that cause muscle weakness, such as neuromuscular blockers used during surgery. It works by increasing the activity of a neurotransmitter called acetylcholine, which helps to improve muscle strength and coordination. Neostigmine is available in both injectable and oral forms, and is typically administered by a healthcare professional. It can cause side effects such as nausea, vomiting, diarrhea, and muscle cramps.

Autonomic agents are computer programs that are designed to perform tasks without human intervention. In the medical field, autonomic agents are often used to automate routine tasks such as patient monitoring, data collection, and analysis. These agents can be programmed to perform specific tasks, such as monitoring a patient's vital signs or analyzing medical images, and can be used to improve the efficiency and accuracy of medical care. Autonomic agents can also be used to provide real-time alerts to medical staff when certain conditions are detected, allowing for prompt intervention and treatment.

Organophosphate poisoning is a type of poisoning that occurs when a person is exposed to organophosphate chemicals. These chemicals are commonly used as pesticides, herbicides, and insecticides. They work by inhibiting the activity of an enzyme called acetylcholinesterase, which is responsible for breaking down a neurotransmitter called acetylcholine in the body. When acetylcholine levels become too high, it can cause overstimulation of the nervous system, leading to symptoms such as muscle twitching, difficulty breathing, and even death. Treatment for organophosphate poisoning typically involves supportive care, such as oxygen therapy and medications to counteract the effects of the poison. In severe cases, hospitalization may be necessary.

Methacholine compounds are a class of drugs that are used to test the function of the bronchial muscles in the lungs. They work by stimulating the muscarinic receptors in the airways, which can cause the muscles to contract and narrow the airways. This can be useful in diagnosing conditions such as asthma, chronic obstructive pulmonary disease (COPD), and other lung diseases that involve inflammation or narrowing of the airways. Methacholine compounds are typically administered as a nebulized solution or as an aerosol, and the response to the drug is measured by observing changes in lung function, such as changes in lung volume or air flow.

Propranolol is a medication that belongs to a class of drugs called beta blockers. It is primarily used to treat high blood pressure, angina (chest pain), and certain types of tremors, including essential tremor and tremors caused by medications. Propranolol can also be used to treat other conditions, such as anxiety disorders, certain types of heart rhythm disorders, and migraine headaches. It works by blocking the effects of adrenaline (a hormone that can cause the heart to beat faster and the blood vessels to narrow) on the heart and blood vessels. Propranolol is available in both oral and injectable forms, and it is usually taken once or twice a day.

Guanethidine is a medication that is used to treat high blood pressure (hypertension) and pheochromocytoma, a rare tumor of the adrenal gland. It works by blocking the production of norepinephrine, a hormone that causes blood vessels to narrow and blood pressure to rise. Guanethidine is typically taken by mouth and is usually given in combination with other medications to treat hypertension. It may also be used to treat other conditions, such as Raynaud's disease, which is a condition that causes the blood vessels in the fingers and toes to narrow, leading to pain and discoloration. Guanethidine can cause side effects, such as dizziness, headache, and low blood pressure, and should be used with caution in people with certain medical conditions, such as heart disease or diabetes.

Glycopyrrolate is a medication that is used to treat certain conditions related to the muscles of the eyes, such as spasms or overactivity. It is also used to treat certain types of muscle spasms in the body, such as those that occur in the urinary tract or the intestines. Glycopyrrolate works by blocking the action of acetylcholine, a chemical that is involved in muscle contraction. This helps to relax the muscles and reduce spasms or overactivity. It is available in both oral and injectable forms and is typically used on an as-needed basis.

Phentolamine is a medication that is used to treat a variety of conditions, including high blood pressure, Raynaud's disease, and erectile dysfunction. It is a non-selective alpha-adrenergic antagonist, which means that it blocks the action of certain hormones and neurotransmitters that cause blood vessels to constrict. This can help to relax blood vessels and improve blood flow to the affected area. Phentolamine is available in both oral and injectable forms, and it is usually given as a short-acting medication. It is important to note that phentolamine can cause side effects, including dizziness, headache, and rapid heartbeat, and it should only be used under the supervision of a healthcare professional.

Cholinesterase reactivators are medications that are used to reverse the effects of cholinesterase inhibitors, which are drugs that block the enzyme cholinesterase. Cholinesterase is an enzyme that breaks down the neurotransmitter acetylcholine, which is important for muscle movement and other bodily functions. When cholinesterase is blocked, acetylcholine builds up in the body, leading to symptoms such as muscle weakness, tremors, and difficulty breathing. Cholinesterase reactivators work by restoring the activity of cholinesterase, allowing the enzyme to break down the excess acetylcholine and alleviate the symptoms of cholinesterase inhibitor poisoning. There are several different types of cholinesterase reactivators, including pralidoxime, obidoxime, and edrophonium. These medications are typically administered intravenously or intramuscularly in the case of severe poisoning. It is important to note that cholinesterase reactivators are not effective against all types of cholinesterase inhibitors, and they may not be able to reverse the effects of certain types of poisoning.

Cholinesterase inhibitors are a class of drugs that are used to treat certain neurological conditions, such as Alzheimer's disease and myasthenia gravis. These drugs work by inhibiting the enzyme cholinesterase, which breaks down the neurotransmitter acetylcholine in the brain. By inhibiting this enzyme, cholinesterase inhibitors help to increase the levels of acetylcholine in the brain, which can improve cognitive function and muscle control in people with these conditions. There are several different types of cholinesterase inhibitors, including donepezil, rivastigmine, and galantamine. These drugs are usually taken orally and are generally well-tolerated, although they can cause side effects such as nausea, diarrhea, and headache.

Bethanechol is a medication that is used to treat urinary retention, a condition in which a person is unable to empty their bladder completely. It works by stimulating the muscles in the bladder and urinary tract to contract, which helps to empty the bladder. Bethanechol is usually given as an injection or a suppository, and it is typically used in people who are unable to urinate due to surgery, injury, or certain medical conditions. It is important to note that bethanechol can cause side effects, such as nausea, vomiting, and diarrhea, and it should only be used under the supervision of a healthcare provider.

In the medical field, an antidote is a substance that is used to counteract or neutralize the effects of a toxic substance or poison. Antidotes are typically administered to individuals who have ingested, inhaled, or been exposed to a harmful substance in order to prevent or treat the harmful effects of the poison. Antidotes can be used to treat a wide range of toxic substances, including drugs, chemicals, and biological agents. For example, activated charcoal is often used as an antidote to treat poisoning from certain drugs, while atropine is used to counteract the effects of nerve gas poisoning. It is important to note that not all toxic substances have an antidote, and in some cases, the best course of treatment may be supportive care rather than the administration of an antidote. Additionally, some antidotes can themselves be harmful if administered in the wrong dosage or to the wrong individual, so it is important for healthcare professionals to be trained in the proper use of antidotes.

Tetrodotoxin (TTX) is a potent neurotoxin that is produced by certain species of marine animals, including pufferfish, cone snails, and some species of sea slugs. TTX is a colorless, odorless, and tasteless compound that is highly toxic to humans and other animals. In the medical field, TTX is primarily used as a research tool to study the function of voltage-gated sodium channels, which are essential for the transmission of nerve impulses. TTX blocks these channels, leading to a loss of electrical activity in nerve cells and muscles. TTX has also been used in the treatment of certain medical conditions, such as chronic pain and epilepsy. However, its use in humans is limited due to its toxicity and the difficulty in administering it safely. In addition to its medical uses, TTX has also been used as a pesticide and a tool for controlling invasive species. However, its use as a pesticide is controversial due to its potential toxicity to non-target organisms and its persistence in the environment.

Cholinergic fibers are a type of nerve fiber that release the neurotransmitter acetylcholine (ACh) at their terminals. These fibers are primarily involved in the transmission of signals within the nervous system and play a crucial role in many physiological processes, including muscle contraction, glandular secretion, and regulation of the autonomic nervous system. Cholinergic fibers can be found throughout the body, including in the central nervous system (CNS), peripheral nervous system (PNS), and enteric nervous system (ENS). In the CNS, cholinergic fibers are involved in learning, memory, and attention, as well as in the regulation of mood and behavior. In the PNS, cholinergic fibers are involved in the control of smooth muscle, cardiac muscle, and glandular secretion. In the ENS, cholinergic fibers are involved in the regulation of gut motility and secretion. Disruptions in cholinergic signaling have been implicated in a number of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. As such, cholinergic fibers are an important area of research in the field of neuroscience and have potential therapeutic applications in the treatment of these disorders.

The autonomic nervous system (ANS) is a part of the peripheral nervous system that controls involuntary bodily functions, such as heart rate, breathing, digestion, and blood pressure. It is responsible for maintaining homeostasis, or a stable internal environment, in the body. The ANS is divided into two branches: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS). The SNS is responsible for the "fight or flight" response, which prepares the body for action in response to a perceived threat. The PNS, on the other hand, is responsible for the "rest and digest" response, which helps the body to relax and conserve energy. The ANS communicates with the central nervous system (CNS) through a series of ganglia (clusters of nerve cells) and nerves. The ANS is an important part of the body's overall functioning and plays a critical role in maintaining health and wellness.

Bethanechol compounds are a class of drugs that are used to stimulate the contractions of smooth muscles in the body. They are primarily used to treat conditions such as urinary retention, constipation, and gastrointestinal disorders. Bethanechol works by activating muscarinic receptors in the smooth muscles, which leads to increased muscle contractions. It is available in both oral and injectable forms.

Bradycardia is a medical condition characterized by a slow heart rate, which is defined as a resting heart rate of less than 60 beats per minute (bpm). The normal resting heart rate for adults is typically between 60 and 100 bpm. Bradycardia can be classified as sinus bradycardia, which is a slow heart rate that originates from the sinoatrial node, or as non-sinus bradycardia, which is a slow heart rate that originates from another part of the heart. Bradycardia can be asymptomatic or may cause symptoms such as dizziness, fainting, shortness of breath, chest pain, or palpitations. It can be caused by a variety of factors, including electrolyte imbalances, medications, heart disease, thyroid disorders, and certain genetic conditions. Treatment for bradycardia depends on the underlying cause and the severity of symptoms. In some cases, no treatment may be necessary, while in others, medications, a pacemaker, or other medical procedures may be recommended.

Oxotremorine is a medication that is used to treat Parkinson's disease and other movement disorders. It is a type of anticholinergic drug that works by blocking the action of acetylcholine, a neurotransmitter that is involved in muscle movement and other bodily functions. Oxotremorine is typically administered as a tablet or injection and is used to reduce tremors, stiffness, and other symptoms of Parkinson's disease. It can also be used to treat other conditions, such as dystonia and Huntington's disease. However, oxotremorine can cause side effects, such as dry mouth, blurred vision, and dizziness, and should be used with caution.

Receptors, cholinergic are a type of protein found on the surface of cells in the body that bind to and respond to the neurotransmitter acetylcholine. These receptors play a role in many physiological processes, including muscle contraction, heart rate, and the regulation of the autonomic nervous system. They are also involved in the transmission of signals between neurons in the central nervous system and between neurons and muscles. In the medical field, cholinergic receptors are important targets for drugs used to treat a variety of conditions, including Alzheimer's disease, myasthenia gravis, and certain types of depression.

Quinuclidinyl Benzilate is a chemical compound that is used as a chemical weapon. It is a nerve agent that works by blocking the transmission of nerve impulses, leading to muscle paralysis and respiratory failure. It is classified as a Schedule 1 substance under the Chemical Weapons Convention and is illegal to possess or use. In the medical field, it is not used for any therapeutic purpose and exposure to it can be extremely dangerous and potentially lethal.

Cholinergic agonists are drugs that stimulate the activity of the cholinergic system, which is a group of neurons and receptors that use the neurotransmitter acetylcholine to transmit signals in the body. These drugs can be used to treat a variety of conditions, including Alzheimer's disease, myasthenia gravis, glaucoma, and urinary incontinence. There are several different types of cholinergic agonists, including muscarinic agonists, which stimulate muscarinic receptors, and nicotinic agonists, which stimulate nicotinic receptors. Muscarinic agonists are often used to treat conditions such as glaucoma, as they can help to increase the production of aqueous humor in the eye, which can help to reduce pressure inside the eye. Nicotinic agonists are often used to treat conditions such as Alzheimer's disease, as they can help to improve memory and cognitive function. Cholinergic agonists can be administered in a variety of ways, including orally, intravenously, and topically. They can also be given as injections or as eye drops. Some cholinergic agonists are available over-the-counter, while others require a prescription from a healthcare provider. It is important to follow the instructions provided by your healthcare provider when taking cholinergic agonists, as they can have side effects and may interact with other medications you are taking.

Scopolamine hydrobromide is a medication that is used to treat motion sickness, nausea, and vomiting. It is a type of anticholinergic medication that works by blocking the action of acetylcholine, a neurotransmitter that is involved in muscle contraction and the regulation of the digestive system. Scopolamine hydrobromide is available in various forms, including tablets, patches, and injections, and is typically used to treat conditions such as motion sickness, postoperative nausea and vomiting, and morning sickness. It is important to note that scopolamine hydrobromide can cause side effects, such as dry mouth, blurred vision, and dizziness, and should only be used under the guidance of a healthcare professional.

Cholinergic agents are drugs that affect the cholinergic system, which is a group of neurons and receptors that use the neurotransmitter acetylcholine to transmit signals. These agents can either increase or decrease the activity of the cholinergic system, depending on the specific drug and the receptors it targets. There are several types of cholinergic agents, including: 1. Acetylcholinesterase inhibitors: These drugs prevent the breakdown of acetylcholine, allowing it to remain in the synaptic cleft for a longer period of time and increasing its effects. Examples include donepezil, rivastigmine, and galantamine, which are used to treat Alzheimer's disease. 2. Nicotinic receptor agonists: These drugs bind to nicotinic acetylcholine receptors and activate them, leading to a variety of effects depending on the specific receptors involved. Examples include nicotine, which is used as a smoking cessation aid, and cytisine, which is being studied as a potential treatment for obesity. 3. Muscarinic receptor antagonists: These drugs block the effects of acetylcholine at muscarinic receptors, leading to a decrease in cholinergic activity. Examples include atropine and scopolamine, which are used as anticholinergics to treat conditions such as motion sickness and to reduce the risk of bleeding during surgery. Cholinergic agents are used to treat a variety of conditions, including Alzheimer's disease, Parkinson's disease, myasthenia gravis, and glaucoma. They can also be used to treat certain side effects of other medications, such as dry mouth and constipation.

Cholinergic Antagonists are a class of drugs that block the action of acetylcholine, a neurotransmitter that plays a crucial role in various bodily functions. These drugs are used to treat a variety of conditions, including glaucoma, myasthenia gravis, and Alzheimer's disease. Cholinergic Antagonists work by binding to receptors on the surface of cells that are sensitive to acetylcholine, preventing the neurotransmitter from binding to the receptors and triggering a response. This can result in a decrease in muscle activity, pupil dilation, and other effects that are mediated by acetylcholine. There are several different types of Cholinergic Antagonists, including muscarinic antagonists, which block the action of acetylcholine at muscarinic receptors, and nicotinic antagonists, which block the action of acetylcholine at nicotinic receptors. Some examples of Cholinergic Antagonists include atropine, scopolamine, and memantine.

Muscarine is a naturally occurring alkaloid that is found in certain mushrooms, such as the fly agaric (Amanita muscaria) and the death cap mushroom (Amanita phalloides). It is also found in some species of snails, particularly those in the genus Conus. In the medical field, muscarine has been studied for its potential therapeutic effects. It is a muscarinic acetylcholine receptor agonist, which means that it binds to and activates these receptors in the body. Muscarinic receptors are found in many different parts of the body, including the brain, heart, lungs, and digestive system. Muscarine has been studied for its potential use in the treatment of a variety of conditions, including Alzheimer's disease, Parkinson's disease, and glaucoma. It has also been used as a research tool to study the effects of muscarinic receptors on various physiological processes. However, it is important to note that muscarine is a potent toxin and can be dangerous if ingested in large quantities. Ingestion of muscarine-containing mushrooms can cause symptoms such as nausea, vomiting, hallucinations, and in severe cases, death. Therefore, it is important to exercise caution when handling and consuming mushrooms, and to seek medical attention immediately if you suspect that you have ingested a toxic mushroom.

Dichlorvos is an organophosphate insecticide that is commonly used to control pests such as cockroaches, ants, and flies. It works by inhibiting the enzyme acetylcholinesterase, which is responsible for breaking down the neurotransmitter acetylcholine in the nervous system. When acetylcholinesterase is inhibited, acetylcholine builds up in the nervous system, leading to overstimulation and eventually paralysis and death of the insect. In the medical field, dichlorvos is not typically used for human treatment, as it can be toxic to humans and other animals. Exposure to dichlorvos can cause symptoms such as nausea, vomiting, dizziness, and difficulty breathing. In severe cases, it can lead to seizures, coma, and death. However, dichlorvos is sometimes used as a pesticide in hospitals and other healthcare facilities to control pests that may pose a risk to patients and staff.

In the medical field, Tropanes are a class of organic compounds that are derived from the alkaloid tropine. They are known for their ability to interact with the cholinergic system in the brain, which can lead to a range of effects on the central nervous system. Some of the most well-known tropane compounds include atropine, scopolamine, and hyoscyamine. These compounds are often used as medications to treat a variety of conditions, including motion sickness, glaucoma, and overactive bladder. They can also be used as muscle relaxants and as sedatives. However, tropane compounds can also have side effects, including dry mouth, blurred vision, dizziness, and confusion. In some cases, they can also be toxic in high doses, and they may interact with other medications or medical conditions. As a result, tropane compounds are typically used with caution and under the supervision of a healthcare professional.

Histamine is a chemical substance that is produced by certain cells in the body, including immune cells and cells in the digestive system. It plays a role in a variety of physiological processes, including the contraction of smooth muscles, the dilation of blood vessels, and the stimulation of nerve endings. In the medical field, histamine is often used as a diagnostic tool to help identify conditions such as allergies, asthma, and certain types of infections. It is also used as a treatment for certain conditions, such as allergic reactions and certain types of digestive disorders.

In the medical field, "cats" typically refers to Felis catus, which is the scientific name for the domestic cat. Cats are commonly kept as pets and are known for their agility, playful behavior, and affectionate nature. In veterinary medicine, cats are commonly treated for a variety of health conditions, including respiratory infections, urinary tract infections, gastrointestinal issues, and dental problems. Cats can also be used in medical research to study various diseases and conditions, such as cancer, heart disease, and neurological disorders. In some cases, the term "cats" may also refer to a group of animals used in medical research or testing. For example, cats may be used to study the effects of certain drugs or treatments on the immune system or to test new vaccines.

Pentolinium tartrate is a medication that is used to treat high blood pressure. It is a diuretic, which means that it helps the body to get rid of excess fluid by increasing the amount of urine that is produced. Pentolinium tartrate works by blocking the action of certain hormones in the body that help to regulate the amount of fluid that is retained. This can help to lower blood pressure and reduce the risk of complications associated with high blood pressure, such as heart attack and stroke.

Soman is a nerve agent that was first synthesized in 1944 by German chemists. It is a colorless, odorless, and tasteless liquid that is highly toxic and can be absorbed through the skin, eyes, and respiratory system. Soman is classified as a Schedule 1 controlled substance under the United States Controlled Substances Act and is illegal to possess, manufacture, or distribute without a valid prescription. In the medical field, soman is primarily used for research purposes to study the effects of nerve agents on the human body. It is also used in some military and law enforcement training exercises to simulate the effects of nerve agents and to test the effectiveness of protective gear and antidotes. However, the use of soman in these contexts is highly regulated and requires strict safety protocols to prevent accidental exposure.

Bretylium compounds are a class of drugs that are used in the medical field to treat certain types of heart arrhythmias, such as atrial fibrillation and ventricular tachycardia. These drugs work by blocking the influx of certain ions, such as sodium and calcium, into cardiac muscle cells, which can help to stabilize the heart rhythm and prevent further arrhythmias from occurring. Bretylium compounds are typically administered intravenously and are used as a last resort when other treatments have failed or are not appropriate. They can cause a number of side effects, including nausea, vomiting, and low blood pressure, and may interact with other medications that are being taken.

Mecamylamine is a medication that is used to treat high blood pressure and to prevent chest pain (angina) in people with heart disease. It works by relaxing blood vessels and decreasing the workload on the heart. Mecamylamine is usually taken by mouth, but it can also be given as an injection. It is not recommended for use in people with certain heart conditions, such as sick sinus syndrome or second- or third-degree heart block. Side effects of mecamylamine may include dizziness, headache, and nausea.

The Muscarinic M3 receptor is a type of protein receptor found in the cells of various organs and tissues in the body. It is a subtype of the muscarinic acetylcholine receptor, which is activated by the neurotransmitter acetylcholine. The M3 receptor is primarily located in the smooth muscle cells of the heart, as well as in the glands and smooth muscles of the respiratory, gastrointestinal, and urinary systems. Activation of the M3 receptor can cause a variety of physiological effects, including contraction of smooth muscle cells, secretion of glandular secretions, and changes in heart rate and blood pressure. In the medical field, the M3 receptor is an important target for the development of drugs used to treat a variety of conditions, including asthma, irritable bowel syndrome, overactive bladder, and certain types of heart disease. Drugs that target the M3 receptor are known as muscarinic M3 receptor antagonists or antagonists.

Norepinephrine, also known as noradrenaline, is a neurotransmitter and hormone that plays a crucial role in the body's "fight or flight" response. It is produced by the adrenal glands and is also found in certain neurons in the brain and spinal cord. In the medical field, norepinephrine is often used as a medication to treat low blood pressure, shock, and heart failure. It works by constricting blood vessels and increasing heart rate, which helps to raise blood pressure and improve blood flow to vital organs. Norepinephrine is also used to treat certain types of depression, as it can help to increase feelings of alertness and energy. However, it is important to note that norepinephrine can have side effects, including rapid heartbeat, high blood pressure, and anxiety, and should only be used under the supervision of a healthcare professional.

Vasoactive Intestinal Peptide (VIP) is a hormone that is produced by the cells of the gastrointestinal tract, as well as by neurons in the brain and other parts of the body. It is a polypeptide hormone, which means that it is made up of chains of amino acids. VIP has a number of effects on the body, including: 1. Relaxing smooth muscle: VIP can cause the muscles in blood vessels to relax, which can lead to a decrease in blood pressure. 2. Increasing the production of insulin: VIP can stimulate the pancreas to produce more insulin, which is a hormone that helps to regulate blood sugar levels. 3. Regulating the digestive system: VIP can stimulate the production of digestive enzymes and the movement of food through the digestive tract. 4. Modulating the immune system: VIP can help to regulate the immune system and reduce inflammation. VIP is also involved in a number of other physiological processes, including the regulation of heart rate and the contraction of the uterus during childbirth. It is sometimes used as a medication to treat conditions such as irritable bowel syndrome and certain types of diarrhea.

Methysergide is a medication that belongs to a class of drugs called ergot alkaloids. It is primarily used to treat migraines and cluster headaches, as well as to prevent nausea and vomiting caused by chemotherapy or surgery. Methysergide works by constricting blood vessels in the brain and reducing inflammation, which can help to alleviate the symptoms of migraines and cluster headaches. It can also help to prevent nausea and vomiting by blocking the action of certain chemicals in the brain that trigger these symptoms. Methysergide is available in both oral and injectable forms, and is typically taken on an as-needed basis for the treatment of migraines and cluster headaches. However, it is important to note that methysergide can have side effects, including nausea, dizziness, and chest pain, and should only be used under the supervision of a healthcare professional.

Metiamide is a medication that is used to treat ulcers in the stomach and duodenum (the first part of the small intestine). It works by reducing the amount of acid that is produced by the stomach, which can help to heal ulcers and prevent them from coming back. Metiamide is usually taken in combination with other medications, such as antibiotics and antacids, to treat ulcers caused by the bacteria Helicobacter pylori. It is available in tablet form and is usually taken once or twice a day, with or without food. Side effects of metiamide may include headache, dizziness, nausea, and diarrhea.

Dimethylphenylpiperazinium iodide is a medication that is used to treat certain types of infections caused by bacteria. It is a type of antibiotic that works by stopping the growth of bacteria. It is usually given by injection into a vein or muscle. Dimethylphenylpiperazinium iodide is not effective against all types of bacteria, and it may not work for everyone. It is important to follow your healthcare provider's instructions carefully when using this medication.

Substance P is a neuropeptide that is involved in the transmission of pain signals in the nervous system. It is a small protein that is produced by sensory neurons in the peripheral nervous system and is released into the spinal cord and brain when these neurons are activated by noxious stimuli such as injury or inflammation. Substance P acts on specific receptors on nerve cells in the spinal cord and brain, triggering the release of other neurotransmitters and hormones that contribute to the perception of pain. It is also involved in other physiological processes, such as regulating blood pressure and heart rate. In the medical field, substance P is often studied in the context of pain management and the development of new pain medications. It is also used as a diagnostic tool in certain conditions, such as inflammatory bowel disease and irritable bowel syndrome, where it may be present in higher levels in the body.

Phenoxybenzamine is a medication that is used to treat high blood pressure (hypertension) and symptoms of an overactive bladder, such as urinary urgency and frequency. It works by relaxing blood vessels and reducing the amount of noradrenaline (a hormone that causes blood vessels to constrict) in the body. This helps to lower blood pressure and improve bladder control. Phenoxybenzamine is usually taken by mouth, and the dosage and duration of treatment will depend on the individual's condition and response to the medication. It is important to follow the instructions of a healthcare provider when taking phenoxybenzamine.

In the medical field, "Receptor, Muscarinic M2" refers to a type of protein receptor found on the surface of cells in the body that is activated by the neurotransmitter acetylcholine. The M2 muscarinic receptor is one of five subtypes of muscarinic receptors, which are named based on their sensitivity to the muscarinic agonist carbachol. The M2 muscarinic receptor is primarily found in the heart, smooth muscle, and glands, and plays a role in regulating a variety of physiological processes, including heart rate, bronchoconstriction, and secretion of saliva and other fluids. Activation of the M2 receptor can produce a range of effects, including relaxation of smooth muscle, slowing of the heart rate, and increased secretion of saliva and other fluids. In the context of medical research and drug development, the M2 muscarinic receptor is an important target for the treatment of a variety of conditions, including asthma, chronic obstructive pulmonary disease (COPD), and certain types of heart disease. Drugs that target the M2 receptor, such as ipratropium bromide and tiotropium bromide, are commonly used to treat these conditions by relaxing bronchial smooth muscle and reducing airway inflammation.

Blood pressure is the force exerted by the blood against the walls of the blood vessels as the heart pumps blood through the body. It is measured in millimeters of mercury (mmHg) and is typically expressed as two numbers: systolic pressure (the pressure when the heart beats) and diastolic pressure (the pressure when the heart is at rest between beats). Normal blood pressure is considered to be below 120/80 mmHg, while high blood pressure (hypertension) is defined as a systolic pressure of 140 mmHg or higher and/or a diastolic pressure of 90 mmHg or higher. High blood pressure is a major risk factor for heart disease, stroke, and other health problems.

Pilocarpine is a medication that is used to treat glaucoma, a condition that can lead to vision loss and blindness. It is also used to treat symptoms of dry eye, such as burning, itching, and redness. Pilocarpine works by increasing the production of tears, which helps to keep the eyes lubricated and reduce dryness. It is available in both eye drops and oral tablets. Pilocarpine can cause side effects such as blurred vision, eye irritation, and increased saliva production. It is important to follow the instructions of your healthcare provider when using pilocarpine and to report any side effects to them.

N-Methylscopolamine is a medication that is used to treat certain types of muscle spasms, such as those that occur in the urinary tract or gastrointestinal tract. It is also used to treat certain types of tremors and to relax muscles during surgery. N-Methylscopolamine works by blocking the action of acetylcholine, a chemical that is involved in muscle contraction. This helps to relax the muscles and reduce spasms. It is available as a tablet, a patch, and an oral solution. Side effects of N-Methylscopolamine may include dry mouth, blurred vision, dizziness, and difficulty urinating. It is important to follow the instructions of your healthcare provider when using this medication.

Tachykinins are a group of neuropeptides that are involved in various physiological processes, including the regulation of smooth muscle contraction, neurotransmission, and the release of other hormones. They are primarily produced in the gastrointestinal tract, respiratory system, and central nervous system. The most well-known tachykinins are substance P, neurokinin A (NKA), and neurokinin B (NKB). These peptides bind to specific receptors on the surface of cells, triggering a cascade of intracellular signaling events that ultimately lead to the desired physiological response. Tachykinins play a role in a variety of medical conditions, including inflammatory bowel disease, irritable bowel syndrome, chronic pain, and asthma. They are also involved in the regulation of the immune system and have been studied as potential therapeutic targets for a range of diseases.

Metipranolol is a medication that belongs to a class of drugs called beta blockers. It is used to treat a variety of medical conditions, including high blood pressure, angina (chest pain), and tremors caused by certain neurological disorders. Metipranolol works by blocking the effects of adrenaline (a hormone that causes the body's "fight or flight" response) on the heart and blood vessels, which can help to lower blood pressure and reduce the workload on the heart. It is available in both oral and injectable forms and is typically taken once or twice a day. Like all medications, metipranolol can cause side effects, including dizziness, fatigue, and nausea. It is important to follow your healthcare provider's instructions carefully when taking this medication.

Adjuvants, anesthesia are substances that are used to enhance the effectiveness of an anesthetic agent. They are typically used in conjunction with the anesthetic to provide a more complete and effective block of pain and other sensations during surgery or other medical procedures. There are several different types of adjuvants that can be used with anesthesia, including opioids, non-opioid analgesics, and local anesthetics. Opioids, such as morphine or fentanyl, are used to provide pain relief and sedation during surgery. Non-opioid analgesics, such as acetaminophen or ibuprofen, can also be used to provide pain relief. Local anesthetics, such as lidocaine or bupivacaine, are used to numb a specific area of the body before surgery or other procedures. Adjuvants can be administered in a variety of ways, including intravenously, orally, or topically. They are typically used in combination with an anesthetic agent to provide a more complete and effective block of pain and other sensations during surgery or other medical procedures.

The Muscarinic M1 receptor is a type of protein receptor found in the cells of various organs and tissues in the body. It is a subtype of the muscarinic acetylcholine receptor family, which is activated by the neurotransmitter acetylcholine. The M1 receptor is primarily located in the central nervous system, where it plays a role in regulating various functions such as cognition, mood, and movement. It is also found in the heart, smooth muscle, and glands, where it regulates processes such as heart rate, muscle contraction, and glandular secretion. Activation of the M1 receptor can produce a range of effects, depending on the tissue and organ in which it is located. For example, activation of the M1 receptor in the heart can cause the heart to beat faster and stronger, while activation in the smooth muscle of the airways can cause bronchodilation, or widening of the airways. In the medical field, the M1 receptor is an important target for the development of drugs used to treat a variety of conditions, including asthma, Alzheimer's disease, and Parkinson's disease.

Solanaceous alkaloids are a group of naturally occurring alkaloids that are found in plants of the Solanaceae family, which includes tomatoes, potatoes, peppers, and eggplants. These alkaloids have a wide range of pharmacological effects and are used in the treatment of various medical conditions. Some of the most well-known solanaceous alkaloids include atropine, scopolamine, and nicotine. Atropine is a potent anticholinergic drug that is used to treat conditions such as glaucoma, irritable bowel syndrome, and motion sickness. Scopolamine is a sedative that is used to treat motion sickness and to prevent nausea and vomiting during surgery. Nicotine is a stimulant that is used to treat conditions such as smoking cessation and Parkinson's disease. Solanaceous alkaloids can also have toxic effects when consumed in large quantities, and some species of the Solanaceae family, such as the nightshade plant, are known to be poisonous. As a result, it is important to use caution when handling and consuming plants from this family, and to seek medical attention if you experience any adverse effects after consuming them.

Benzilates are esters of benzoic acid and alcohols. They are commonly used as preservatives in pharmaceuticals and personal care products, as well as in food and beverages. In the medical field, benzilates are used as antiseptics and disinfectants to prevent the growth of microorganisms on surfaces and in solutions. They are also used as intermediates in the synthesis of other chemicals. Some benzilates have been reported to have potential toxic effects, including skin irritation and sensitization, and may cause allergic reactions in some individuals.

Dicyclomine is a medication that is used to treat symptoms of irritable bowel syndrome (IBS) and peptic ulcers. It works by blocking the action of acetylcholine, a chemical that helps to relax the muscles in the digestive tract. This can help to reduce cramping and abdominal pain, as well as improve bowel movements. Dicyclomine is available in tablet and capsule form and is usually taken three to four times a day. It may cause side effects such as dry mouth, blurred vision, and dizziness.

Injections of atropine are used in the treatment of symptomatic or unstable bradycardia. Atropine was previously included in ... Atropine or diphenhydramine can be used to treat muscarine intoxication.[medical citation needed] Atropine has been observed to ... atropine is poisonous.[medical citation needed] Atropine is sometimes added to potentially addictive drugs, particularly ... Even though atropine has not been officially indicated for either of these purposes by the FDA, it has been used by physicians ...
Atropine is the third album released by the black metal band Velvet Cacoon. It features a completely dark ambient sound. CD ...
"Atropine". pubchem.ncbi.nlm.nih.gov. Retrieved 2021-08-08. Richards, John R.; Garber, Dariush; Laurin, Erik G.; Albertson, ... out by the ingestion and processing of drugs such as cocaine or atropine. This section discusses target heart rates for healthy ...
"Atropine". The American Society of Health-System Pharmacists. Archived from the original on 2015-07-12. Retrieved Aug 13, 2015 ...
In the 1850s, atropine was used as antispasmodic in asthma treatment and as morphine antidote for its mydriatic effect. Bezold ... Combined use with atropine increases the risk of severe hypertension. Alzheimer's disease e.g. rivastigmine and donepezil. May ... Atropine decreases the absorption of levodopa. Preventing travel sickness, relieve stomach cramps or spasms, e.g. hyoscine. ... Shutt LE, Bowes JB (May 1979). "Atropine and hyoscine". Anaesthesia. 34 (5): 476-90. doi:10.1111/j.1365-2044.1979.tb06327.x. ...
Geiger; Hesse (1833). "Fortgesetzte Versuche über Atropin" [Continued experiments on atropine]. Annalen der Pharmacie (in ... The effects of atropine on the central nervous system include memory disruption, which may lead to severe confusion. The major ... "Atropine Eye Drops". Archived from the original on 8 July 2008. Retrieved 2008-07-08. Wood, George Bacon (1867). A Treatise on ... 3.6, "History of Atropine as a poison". Robert S. Holzman, MD (July 1998). "The Legacy of Atropos". Anesthesiology. 89 (1): 241 ...
Varghese, S.; Vettath, N.; Iyer, K.; Puliyel, J. M.; Puliyel, M. M. (1990). "Ocular atropine induced psychosis--is there a ... Bergman, K. R.; Pearson, C.; Waltz, G. W.; Evans R. III (1980). "Atropine-induced psychosis. An unusual complication of therapy ... Prednisone and other corticosteroids Isotretinoin Anticholinergic drugs atropine scopolamine antidepressants L-dopa ... with inhaled atropine sulfate". Chest. 78 (6): 891-893. doi:10.1378/chest.78.6.891. PMID 7449475. ...
It is mainly known for the other alkaloids derived from it, which include atropine and cocaine, among others. Tropane alkaloids ... "Atropine content of plants". USDA, ARS, National Genetic Resources Program. Phytochemical and Ethnobotanical Databases. [Online ...
The antidote is atropine. T-1123 is a quaternary ammonium ion. A phenyl carbamate ester is bonded in the meta position to the ...
Atropine is an alkaloid first found in Atropa belladonna, a member of the nightshade family. While atropine was first isolated ... Overdosing of atropine may lead to atropine poisoning which results in side effects such as blurred vision, nausea, lack of ... "Atropine Side Effects Center". "Resveratrol: MedlinePlus Supplements". medlineplus.gov. Retrieved 2020-04-07. Vang O, Ahmad N, ... Currently atropine is administered intravenously to treat bradycardia and as an antidote to organophosphate poisoning. ...
Active ingredients are listed as: phenobarbital (16.2 mg), hyoscyamine sulfate (0.1037 mg), atropine sulfate (0.0194 mg), and ... compared Donnatal® tablets (hyoscyamine sulfate - 0.1037 mg; atropine sulfate - 0.0194 mg; scopolamine hydrobromide - 0.0065 mg ... and phenobarbital - 16.2 mg) to belladonna alkaloids alone (hyoscyamine sulfate - 0.1037 mg; atropine sulfate - 0.0194 mg; ...
An emergency antidote is atropine. Diazinon was developed in 1952 by the Swiss company Ciba-Geigy (now Novartis) to replace the ... Geller, Robert J.; Lopez, Gaylord P.; Cutler, Stephen; Lin, Diana; Bachman, George F.; Gorman, Susan E. (2003). "Atropine ... including the antidotes atropine and oxime. Gastric Lavage[citation needed] Patients that continue to improve over the first 4 ... availability as an antidote for nerve agent casualties: Validated rapid reformulation of high-concentration atropine from bulk ...
The specific antidote is atropine. Inducing vomiting to remove mushroom contents is also prudent due to the speed of onset of ...
"Atnaa Atropine And Pralidoxime Chloride Auto-Injector- atropine and pralidoxime chloride kit". DailyMed. 22 March 2017. ... The ATNAA provides atropine and pralidoxime chloride in a single delivery system, although the two drugs are separate within ... "Duodote- atropine and pralidoxime chloride kit". DailyMed. 22 October 2018. Retrieved 27 May 2020. FDA approval process "ATNAA ... "Atropine mixture with pralidoxime chloride". Drug Information Portal. U.S. National Library of Medicine. Portal: Medicine ( ...
Atropine is a parasympathetic blocker. The common premedication dose for atropine is 0.01-0.02 mg/kg. With standard intravenous ... Atropine is a muscarinic receptor antagonist, thus blocking the vagal response. The dose is 10 mcg/kg. It has quick onset of ... Atropine may also be used as a premedication agent in pediatrics to prevent bradycardia caused by hypoxia, laryngoscopy, and ... Atropine - The process of intubation can cause massive stimulation to vagus nerve, causing bradycardia (low heart rate). The ...
Atropine is administered for bradycardia. It acts on the vagus nerve so it's not effective in heart transplant patients as the ...
... bottles of Valium and atropine; several driver's licenses; a blue hooded parka; and underwear too small to fit Gacy. They also ...
... atropine, hyoscyamine, scopolamine, etc.) Anticonvulsants (topiramate, carbamazepine, lamotrigine, etc.) Antihistamines ( ...
The specific antidote is atropine. List of deadly fungi Carluccio A (2003). The Complete Mushroom Book. Quadrille. ISBN 1-84400 ...
The systematic name is atropine acylhydrolase. Other names in common use include tropine esterase, atropinase, and atropine ... Moog P, Krisch K (1974). "[The purification and characterization of atropine esterase from rabbit liver microsomes (author's ... The enzyme tropinesterase (EC 3.1.1.10) catalyzes the reaction atropine + H2O ⇌ {\displaystyle \rightleftharpoons } tropine + ...
The most common is called Atropine. Indirect-acting antagonist- drugs that inhibit the release/production of neurotransmitters ...
"Atropine - Myasthenia-gravis medicines and drugs". NHS Choices. 2014. Archived from the original on 12 July 2015. Retrieved 11 ... Another medication used for MG, atropine, can reduce the muscarinic side effects of acetylcholinesterase inhibitors. ...
The US Army has funded studies of the use of galantamine along with atropine in the treatment of a number of nerve agents, ... Increasing the dose of galantamine from 5 to 8 mg/kg decreased the dose of atropine needed to protect experimental animals from ... The use of a fast-acting peripheral anticholinergic drug such as atropine can block the receptors where acetylcholine acts to ... In the treatment of nerve agent poisoning, atropine is most often administered along with a Hagedorn oxime such as pralidoxime ...
"Atropine and bradycardia after myocardial infarction". Kounis NG, Chopra RK. Ann Intern Med 1974; 81: 117-8. "Oxytetracycline- ...
The mydriatic of choice is atropine. In the periods between acute attacks, no therapy has been shown to be beneficial. Horses ...
... treatment to speed it may include atropine. The corticosteroid medication methylprednisolone has been studied for use in SCI ...
Paton, W.D.M.; Rang, H.P. (1965). "The Uptake of Atropine and Related Drugs by Intestinal Smooth Muscle of the Guinea-Pig in ... Clark, A.J. (1926). "The antagonism of acetyl choline by atropine". Journal of Physiology. 61 (4): 547-546. doi:10.1113/ ...
Pharmacological treatments as; gabapentin, pregabalin, neostigmine/atropine, methylxanthines, and triptans. Minimally invasive ... "Addition of Neostigmine and Atropine to Conventional Management of Postdural Puncture Headache: A Randomized Controlled Trial ...
Atropine can be given when children produce a vagal response, evidenced by bradycardia, in response to intubation. Some ... Pretreatment includes 100% oxygen, lidocaine, and atropine. 100% oxygen should be administered for 3 to 5 minutes. The time ...
This pathway will be inhibited by atropine. Gastrin is transferred from a specific type of G cell in the gastric epithelium to ... which is of particular importance because the administration of atropine will not block the vagal stimulation of the G cells, ...
Atropine Ophthalmic: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before using atropine eye drops or eye ointment,. *tell your doctor and pharmacist if you are allergic to atropine, belladonna ... Atropine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *eye irritation and ... Atropine comes as a solution (liquid) to instill in the eyes and an eye ointment to apply to the eyes. The drops are usually ...
Atropine Ophthalmic Atropine Care 1% ... Isopto® Atropine ... Ophthalmic atropine is used before eye examinations to dilate ( ... Wen L, Fong A, Goon YY, Tan D. Atropine for the treatment of childhood myopia: changes after stopping atropine 0.01%, 0.1% and ... Atropine has been added to diphenoxylate tablets to cause ... and pharmacist if you are allergic to diphenoxylate, atropine, ... They are: Atropine Diphenoxylate (an opioid) ... Medicines with these names contain atropine and diphenoxylate: Lofene Logen ...
Although low-dose atropine has shown promise for myopia control in children, the responses to treatment vary widely. In the Low ... Although low-dose atropine has shown promise for myopia control in children, the responses to treatment vary widely. In the Low ... Although age and atropine concentration were significant risk factors for SE progression and AL elongation, there was no ... All concentrations of atropine were well tolerated, regardless of age. The mean accommodation amplitude de-creased with age, ...
Will atropine cause permanent dry mouth? My dog was put under while her ears where checked and cleaned. She was given atropine ... Atropine is removed from the body by the liver and kidneys. Since it took so long for your dog to recover from the drugs that ... Both the loss of balance and dry mouth that you describe are potential side effects of atropine administration. These effects ...
Atropine Ophthalmic Ointment 3.5gm. $39.08 Prescription items are NON-RETURNABLE and NON REFUNDABLE Atropine Sulfate Ophthalmic ... Prescription items are NON-RETURNABLE and NON REFUNDABLE Atropine Sulfate Ophthalmic Atropine Ophthalmic Ointment 1% is a ... Usage: Atropine should be instilled as directed by your veterinarian. Do not touch the dropper or tube opening to any surface, ... Benefits: Atropine is used to controls pain due to corneal and uveal disease. For use: Dogs, cats & horses Strength/Size: 1% ...
Solution; Oral; Atropine Sulfate 0.025 mg; Diphenoxylate Hydrochloride 2.5 mg / 5 ml*Tablets; Oral; Atropine Sulfate 0.025 mg; ... A03BA01 - Atropine*A07DA01 - Diphenoxylate*S01FA01 - Atropine. Pharmaceutical companies: manufacturers, researchers, developers ...
Clinical findings against which to titrate atropine dosage. Preferred routes of administration of atropine. Type of ... cholinesterase inhibitor toxicity that may require extremely high doses of atropine. ... Describing Mechanism by which atropine counters the effects of the cholinergic toxidrome. ... Diagnostic Use: The "Atropine Challenge". A number of authors have recommended the "atropine challenge" as an aid to diagnosis. ...
... atropine-pralidoxime), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation ... encoded search term (atropine/pralidoxime (ATNAA%2C DuoDote)) and atropine/pralidoxime (ATNAA, DuoDote) What to Read Next on ... atropine IV/IM. Monitor Closely (1)atropine IV/IM and pralidoxime both decrease cholinergic effects/transmission. Use Caution/ ... atropine decreases levels of droperidol by pharmacodynamic antagonism. Use Caution/Monitor.. atropine decreases levels of ...
Atropine or atropine sulfate carries FDA indications for anti-sialagogue/anti-vagal effect, organophosphate/muscarinic ... Atropine acts as a competitive, reversible antagonist of muscarinic receptors: an anticholinergic drug. This activity outlines ...
The study group used a placebo for one year followed by half a year of atropine 0.01%, while the control group used atropine ... Atropine 0.01% was able to alleviate hyperopia most noticeably in the temporal retina. Photo: Joseph W. Sowka, OD, and Alan G. ... Atropine has been used for over 100 years as an effective treatment in myopia control, although optimal dosage recommendations ... The effect of atropine 0.01% eyedrops on relative peripheral refraction in myopic children. Eye. January 29, 2022. [Epub ahead ...
Generic equivalents for Atropine Sulfate... What are generics?. Atropine Sulfate 1% Drops ...
Each mL contains atropine sulfate, 0.1 mg; ... ATROPINE SULFATE (UNII: 03J5ZE7KA5) (ATROPINE - UNII:7C0697DR9I) ATROPINE ... Diacerein or atropine was applied to the MFD ... Atropine and diacerein suppressed levels of the myopia-related TGF-ß1 and MMP- ... ATROPINE SULFATE INJ. USP is supplied in the following dosage forms. NDC 51662-1378-1 ATROPINE SULFATE INJ. USP (0.1 mg/mL) 1 ... Atropine Derivatives - Preferred Concept UI. M0001936. Scope note. Analogs and derivatives of atropine. .... ...
Is Atropine a Viable Treatment for Childhood Myopia Atropine has been shown to effectively slow down progressive myopia. This ... Atropine for Myopia Management Videos. Atropine Drops: A Solution to Childhood Myopia ... Atropine for Myopia Management. How can atropine eye drops slow down the progression of my childs myopia? ... What is Atropine Treatment for Nearsightedness in Children? In addition to other available options for treating childhood ...
... atropine is not indicated. Intravenous (IV) atropine indications include patients with hypersalivation, bronchial secretions, ... If Atropine is given slowly (or in low doses) to correct a bradycardia, it could paradoxically accentuate the parasympathetic ... Atropine is only useful to counter muscarinic effects (pralidoxime and benzodiazepines act on the others). Remember 2-PAM ... Remember that Atropine is in part of a competitive landscape with Acetylcholine (ACH) - the main neurotransmitter of the ...
Control myopia progression in children with atropine eye drops. Schedule an appointment at Scott Eye Care. Learn about ... Low-dose atropine eye drops is an effective approach to slowing the progression of myopia in children who are 5 to 15 years of ...
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Atropine IV is also used to prevent bradycardic effects of neostigmine when used to reverse the effects of competitive muscle ... 1 mg atropine sulfate in 1 ml ampoule (1 mg/ml) for SC, IM, IV injection ...
Atropine. Health and Medicine Reference Covering Thousands of Diseases and Prescription Drugs. ... Atropine. Atropine is a tropane alkaloid extracted from the deadly nightshade (Atropa belladonna) and other plants of the ... Forty-day-old rats were given varying doses (0.0, 7.5, or 15.0 mg/kg/5 ml) of atropine sulfate or atropine methylnitrate and ... Military Implications of Atropine Hypersensitivity. Atropine hypersensitivity is a rarely reported condition. However, in the ...
... but in the end he failed because of Lu atropine lower blood pressure Ming, this atropine lower blood pressure time he used it ... You must atropine lower blood pressure know that the shield that was as light as nothing in the hands of Man Niu and Lu Yu was ... As for atropine lower blood pressure the swords outside, most of them are broken swords, or the sword soul inside is too fierce ... Atropine Lower Blood Pressure ?. After Lin Fei finished speaking, Han Yuanshan and several elders couldnt wait to enter the ...
Atropine ophthalmic. *View full drug information. This agent acts at parasympathetic sites in smooth muscle to block the ...
Mix the chloroform with the liniment of atropine.. The British Pharmaceutical Codex, 1911, was published by direction of the ... Liniment of Atropine. to 100.00. ,. to 20 fl. ounces. ... Related entry: Atropine Sulphate. Chloroform. 12.50. ,. 2 ½ fl ... Linimentum Arnicae, B.P.C. Liniment of Arnica. up Linimentum Atropinae, B.P.C. Liniment of Atropine. › ... Linimentum Atropinae cum Chloroformo, B.P.C. Liniment of Atropine with Chloroform.. ...
Atropine Injection Veterinary for horses, cows, sheep, dogs & cats. ... Atropine. Atropine Injection veterinary 10 mg/ml. Atropine Injection Veterinary for horses, cows, sheep, dogs & cats. ... Atropine is included in the World Health Organization List of Essential Medicines. Atropine Injection veterinary 10 mg/ml is a ... Atropine Injection veterinary 10 mg/ml is often given with several anesthetic agents to prevent a slow heart rate. It is also ...
Atropine - A Cure For Short-sightedness?. by Nikhil Jain February 24, 2023. Day after day myopia is affecting more number of ...
LOMOTIL medication page for healthcare professionals to search for scientific information on Pfizer medications. Also find the prescibing information, announcements, resources, and channels to connect with Pfizer Medical Information.
In such situations, it is suggested by eye doctors that parents turn to Atropine - a form of weekly eye drops treatment - that ...
PMD is one of the leading distributors of pharmaceutical products in the Lebanese market. Established in Beirut in 1993, chaired by Dr. Ghassan Al-Amine, President of Lebanese order of Pharmacists.. ...
Atropine sulphate drops are known to decrease salivary secretion due to their muscarinic antagonistic activity. The present ... The Impact of Sublingual Atropine Eyedrops on Salivary Flow in 7-17 Year Old Children during Routine Dental Procedures: A ... Case group was given atropine sulphate drops sublingually in a dose dependent manner and control group received distilled water ... Clinical relevance: The duration of effect of atropine drops, the route of administration, and reversibility of effect in ...
Atropine. Name. Atropine 1mg/1ml solution for injection ampoules. Preferred name basis. BAN - British Approved Name. ... Atropine 1mg/1ml solution for injection ampoules (Alliance Healthcare (Distribution) Ltd). *Atropine 1mg/1ml solution for ... Home / Virtual products: At / Atropine 1mg/1ml solution for injection ampoules. Atropine 1mg/1ml solution for injection ... Atropine sulfate. Form & Route. solutioninjection.intravenous. solutioninjection.subcutaneous. solutioninjection.intramuscular ...
Atropine. TPF Noob!. Joined. Nov 9, 2007. Messages. 128. Reaction score. 0. Location. Sweden Can others edit my Photos. Photos ...
  • Atropine or atropine sulfate carries FDA indications for anti-sialagogue/anti-vagal effect, organophosphate/muscarinic poisoning, and bradycardia. (drugbank.com)
  • Generic equivalents for Atropine Sulfate . (drugmartdirect.com)
  • It is generally available as a sulfate salt and oral atropine is only available in combination products. (sharkvet.com)
  • Atropine sulfate blocks the muscarinic effects of acetylcholine that cause bronchorrhoea, hypersalivation, bronchoconstriction and bradycardia, thereby reducing these effects. (who.int)
  • Patients were categorized by age (4-6 years, 7-9 years, and 10-12 years) and were assigned randomly to receive atropine 0.05%, 0.025%, 0.01%, or placebo. (aao.org)
  • Atropine 0.01% was able to alleviate hyperopia most noticeably in the temporal retina. (reviewofoptometry.com)
  • The study group used a placebo for one year followed by half a year of atropine 0.01%, while the control group used atropine 0.01% for one year and then switched to placebo eye drops for half a year. (reviewofoptometry.com)
  • They concluded that in children with myopia, "Atropine 0.01% eye drops and cycloplegia had more of an effect on temporal relative peripheral refractions. (reviewofoptometry.com)
  • The effect of atropine 0.01% eyedrops on relative peripheral refraction in myopic children. (reviewofoptometry.com)
  • Evaluation of the Levels of Low-dose Topical Atropine (0.01%) in Aqueous and Vitreous Humor in Human Eyes. (bvsalud.org)
  • This is the first human study that confirmed penetration of 0.01% topical atropine in aqueous and vitreous humor in live human eyes . (bvsalud.org)
  • The purpose of this study was to evaluate penetration of low- dose atropine 0.01% in aqueous and vitreous humor . (bvsalud.org)
  • One drop of 0.01% atropine was put in the eye to be operated. (bvsalud.org)
  • Measurable concentration of low- dose topical atropine (0.01%) was noted in aqueous and vitreous humor after instillation of a single drop of low- dose atropine . (bvsalud.org)
  • How can atropine eye drops slow down the progression of my child's myopia? (amplifyeye.care)
  • In addition to other available options for treating childhood myopia , one increasingly popular way to slow the progression is the use of low concentration atropine drops. (amplifyeye.care)
  • Are low dose atropine drops a cure for slowing progression in childhood nearsightedness? (amplifyeye.care)
  • Low-dose atropine eye drops is an effective approach to slowing the progression of myopia in children who are 5 to 15 years of age. (scotteye.com)
  • In such situations, it is suggested by eye doctors that parents turn to Atropine - a form of weekly eye drops treatment - that complements spectacle and contact lens usage in children. (myopia.com.sg)
  • Atropine sulphate drops are known to decrease salivary secretion due to their muscarinic antagonistic activity. (sysrevpharm.org)
  • The present study was undertaken to quantitatively assess decrease in salivary secretion in children post administration of atropine sulphate drops sublingually, during routine dental procedures. (sysrevpharm.org)
  • Case group was given atropine sulphate drops sublingually in a dose dependent manner and control group received distilled water in a similarly calculated dose. (sysrevpharm.org)
  • The duration of effect of atropine drops, the route of administration, and reversibility of effect in children can be interpreted as adopting the said drug as an adjunct to conventional saliva control measures. (sysrevpharm.org)
  • In atropine-induced mydriasis, the mechanism of action involves blocking the contraction of the circular pupillary sphincter muscle (which is normally stimulated by acetylcholine release), thereby allowing the radial pupillary dilator muscle to contract and dilate the pupil. (the-medical-dictionary.com)
  • Ophthalmic atropine is used before eye examinations to dilate (open) the pupil, the black part of the eye through which you see. (medlineplus.gov)
  • you should know that your vision may be blurred during your treatment with atropine ophthalmic ointment. (medlineplus.gov)
  • Atropine Injection veterinary 10 mg/ml is relatively inexpensive and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal, and ophthalmic methods. (sharkvet.com)
  • Type of cholinesterase inhibitor toxicity that may require extremely high doses of atropine. (cdc.gov)
  • 2002) Thus, even when given sufficient doses of atropine, patients may need artificial ventilation, sometimes for weeks. (cdc.gov)
  • Some cases of mild to moderate poisonings may improve with these doses of atropine. (cdc.gov)
  • One author suggest avoiding large doses of pre-mixed atropine containing alcohol preservatives in children out of concern that alcohol toxicity could complicate the situation. (cdc.gov)
  • If Atropine is given slowly (or in low doses) to correct a bradycardia, it could paradoxically accentuate the parasympathetic actions of ACH - so therefore ACH would be considered the victor and thus the heart rate would continue to be slow or potentially get worse. (passwithpass.com)
  • Atropine is incapacitating at doses of 10 to 20 mg per person. (manifestingpsychic.com)
  • Medicines with these names contain atropine and diphenoxylate: Lofene Logen Lomanate Lomotil Lonox Other medicines may also contain atropine and diphenoxylate. (nih.gov)
  • Remember that Atropine is in part of a competitive landscape with Acetylcholine (ACH) - the main neurotransmitter of the parasympathetic nervous system. (passwithpass.com)
  • Generally, atropine lowers the "rest and digest" activity of all muscles and glands regulated by the parasympathetic nervous system. (the-medical-dictionary.com)
  • The main action of the parasympathetic nervous system is to stimulate the M2 muscarinic receptor in the heart, but atropine inhibits this action. (the-medical-dictionary.com)
  • Atropine lives in your protocol for various ailments including symptomatic bradycardia and for rarer occurrences of organophosphate poisoning. (passwithpass.com)
  • Intravenous (IV) atropine indications include patients with hypersalivation, bronchial secretions, or bradycardia. (passwithpass.com)
  • If the bradycardia is persistent and the patient is symptomatic with signs of AMS, hypotension, or signs of shock, give Atropine in a 1 mg bolus (repeat to a 3 mg max if necessary) If this is ineffective consider TCP and/or vasopressors. (passwithpass.com)
  • Injections of atropine are used in the treatment of bradycardia (an extremely low heart rate) and asystole, which is a condition of pulseless electrical activity (PEA) in cardiac arrest. (the-medical-dictionary.com)
  • If the patient is symptomatic, standard advanced cardiac life support (ACLS) guidelines for bradycardia, including the use of atropine and transcutaneous pacing, are indicated. (medscape.com)
  • tell your doctor and pharmacist if you are allergic to atropine, belladonna, or any other drugs. (medlineplus.gov)
  • Atropine Injection veterinary 10 mg/ml is a muscarinic antagonist that is used to treat poisoning by muscarinic agents, including organophosphates and other drugs. (sharkvet.com)
  • He was intubated and initially received 8 mg of atropine to control his secretions. (cdc.gov)
  • Automatic injectors: the U.S. Armed Forces uses autoinjectors, containing 2 mg of atropine. (cdc.gov)
  • These atropine autoinjectors are packaged with a 2-PAM autoinjector, called Mark I kits. (cdc.gov)
  • Troops who are likely to be attacked with chemical weapons often carry autoinjectors with atropine and obidoxime which can be quickly injected into the thigh. (the-medical-dictionary.com)
  • Troops who are likely to be attacked with chemical weapons often carry autoinjectors with atropine and an oxime, for rapid injection into the muscles of the thigh. (manifestingpsychic.com)
  • Although age and atropine concentration were significant risk factors for SE progression and AL elongation, there was no interaction between the two, indicating that they influence myopia progression inde-pendently. (aao.org)
  • They noted that this atropine concentration was able to alleviate relative hyperopia in the temporal retina and the hyperopic shift before cycloplegia. (reviewofoptometry.com)
  • In addition to low concentration atropine for myopia, many children will still require the corrective measures of prescription glasses or contact lenses to achieve optimal vision improvement. (amplifyeye.care)
  • Atropine is only useful to counter muscarinic effects (pralidoxime and benzodiazepines act on the others). (passwithpass.com)
  • Atropine is a tropane alkaloid extracted from the deadly nightshade ( Atropa belladonna ) and other plants of the family Solanaceae. (the-medical-dictionary.com)
  • Per AHA, Atropine should only be considered a temporizing measure while awaiting a transcutaneous pacemaker for patients with symptomatic high-degree AV block. (passwithpass.com)
  • Except for the use of atropine in selected cases of transient AV block, permanent cardiac pacing has replaced medical interventions in the treatment of patients with symptomatic, otherwise untreatable, AV block. (medscape.com)
  • Symptomatic patients should be treated with atropine and transcutaneous pacing. (medscape.com)
  • Atropine works by competitively occupying muscarinic receptor sites, thus reducing the effects of excessive acetylcholine on these sites brought about by cholinesterase inhibition. (cdc.gov)
  • This occurs because atropine is a competitive inhibitor of the muscarinic acetylcholine receptors. (the-medical-dictionary.com)
  • By blocking the action of acetylcholine at muscarinic receptors, atropine also serves as an antidote for poisoning by organophosphate insecticides and nerve gases. (the-medical-dictionary.com)
  • Atropine Injection veterinary 10 mg/ml is a competitive, reversible antagonist of muscarinic receptors that blocks the effects of acetylcholine and other choline esters. (sharkvet.com)
  • However, by blocking the action of acetylcholine at muscarinic receptors, atropine also serves as a treatment for poisoning by organophosphate insecticides and nerve agents, such as tabun (GA), sarin (GB), soman (GD), and VX. (manifestingpsychic.com)
  • Atropine Injection veterinary 10 mg/ml is often given with several anesthetic agents to prevent a slow heart rate. (sharkvet.com)
  • Atropine Injection veterinary 10 mg/ml should not be used in animals known to be hypersensitive or sensitive to the drug. (sharkvet.com)
  • Topical atropine is used as a cycloplegic, to temporarily paralyze accommodation, and as a mydriatic, to dilate the pupils. (the-medical-dictionary.com)
  • Cisapride (Propulsid)Belladonna contains atropine. (nih.gov)
  • All concentrations of atropine were well tolerated, regardless of age. (aao.org)
  • Treat with high concentrations of humidified oxygen en route to the hospital. (medscape.com)
  • Although low-dose atropine has shown promise for myopia control in children, the responses to treatment vary widely. (aao.org)
  • These results suggest that among the factors studied, age was the only predictor of response to atropine treatment. (aao.org)
  • Atropine has been used for over 100 years as an effective treatment in myopia control, although optimal dosage recommendations are still being debated and studied. (reviewofoptometry.com)
  • What is Atropine Treatment for Nearsightedness in Children? (amplifyeye.care)
  • Atropine treatment is relatively simple. (amplifyeye.care)
  • Additional treatment included a continuous atropine infusion of 9 mg per hour for 5 days and a pralidoxime infusion (500 mg per hour) to a total of 26 g before ventilatory support could be discontinued. (cdc.gov)
  • In the second year, those initially given placebo received 0.05% atropine. (aao.org)
  • If there are local symptoms just in the eyes or respiratory tract, atropine is not indicated. (passwithpass.com)
  • Atropine may cause side effects. (medlineplus.gov)
  • Atropine can reduce the effects of cisapride. (nih.gov)
  • Both the loss of balance and dry mouth that you describe are potential side effects of atropine administration. (vetinfo.com)
  • Mechanism by which atropine counters the effects of the cholinergic toxidrome. (cdc.gov)
  • Clinical findings against which to titrate atropine dosage. (cdc.gov)
  • After an initial dose of 2 mg atropine, her clinical status improved rapidly. (cdc.gov)
  • Atropine degrades slowly, typically wearing off in 2 to 3 days, so tropicamide is generally preferred as a mydriatic. (the-medical-dictionary.com)
  • Atropine acts as a competitive, reversible antagonist of muscarinic receptors: an anticholinergic drug. (drugbank.com)
  • Symptoms typically resolved rapidly with atropine therapy. (cdc.gov)
  • Atropine should be used with caution in animals that have rapid heart rates or if kidney, heart, or liver function is impaired. (sharkvet.com)
  • However, atropine should be administered with caution in patients with suspected myocardial ischemia, as ventricular dysrhythmias can occur in this situation. (medscape.com)
  • Patients with infranodal second-degree AV block are unlikely to benefit from atropine. (medscape.com)
  • In addition, in patients who have denervated hearts (eg, patients who have undergone a cardiac transplant), atropine is also not likely to be effective. (medscape.com)
  • Preferred routes of administration of atropine. (cdc.gov)
  • Two experiments investigated the mechanism for changes in measures of behavioral arousal inhibition in rats following administration of atropine. (the-medical-dictionary.com)
  • The goal of atropine administration is to improve conduction through the AVN by reducing vagal tone via atropine-induced receptor blockade. (medscape.com)
  • Atropine was injected 45 minutes later at 75 micrograms/kilogram intravenously (iv) and caused the mean pressure to return to control levels. (cdc.gov)
  • At that time, in addition to collecting atropine lower blood pressure all kinds of rare and even extinct natural treasures on the mainland, they can also comprehend the profound meaning of the true law of ice. (sc-celje.si)
  • Atropine comes as a solution (liquid) to instill in the eyes and an eye ointment to apply to the eyes. (medlineplus.gov)
  • Atropine is not thought to have significant effect on nicotinic receptors, and thus does not counteract fasciculations, weakness, or flaccid paralysis. (cdc.gov)
  • Therefore, atropine can be used to reduce the effect of ACh. (the-medical-dictionary.com)
  • It has been suggested that when these physiological changes do not occur with this dose (sometimes referred to as an atropine challenge ), this is indicative of cholinesterase inhibitor toxicity. (cdc.gov)