Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Compounds with a BENZENE fused to IMIDAZOLES.
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.
An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR.
Abnormally rapid heartbeats originating from one or more automatic foci (nonsinus pacemakers) in the HEART ATRIUM but away from the SINOATRIAL NODE. Unlike the reentry mechanism, automatic tachycardia speeds up and slows down gradually. The episode is characterized by a HEART RATE between 135 to less than 200 beats per minute and lasting 30 seconds or longer.
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
A generic expression for any tachycardia that originates above the BUNDLE OF HIS.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.
A series of actions, sometimes symbolic actions which may be associated with a behavior pattern, and are often indispensable to its performance.
The chambers of the heart, to which the BLOOD returns from the circulation.
Reflex contraction of a muscle in response to stretching, which stimulates muscle proprioceptors.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The act or practice of killing for reasons of mercy, i.e., in order to release a person or animal from incurable disease, intolerable suffering, or undignified death. (from Beauchamp and Walters, Contemporary Issues in Bioethics, 5th ed)
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.
A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).
Irregular HEART RATE caused by abnormal function of the SINOATRIAL NODE. It is characterized by a greater than 10% change between the maximum and the minimum sinus cycle length or 120 milliseconds.
The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).
Diseases that do not exhibit symptoms.
The veins that return the oxygenated blood from the lungs to the left atrium of the heart.
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic biomedical research that is not targeted to specific diseases and funds studies on genes, proteins, and cells, as well as on fundamental processes like communication within and between cells and metabolism. It was established in 1962.
Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The gaseous envelope surrounding a planet or similar body. (From Random House Unabridged Dictionary, 2d ed)
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.

Pre-procedural prediction of termination of persistent atrial fibrillation by catheter ablation as an indicator of reverse remodeling of the left atrium. (1/11)

BACKGROUND: The pre-procedural prediction of atrial fibrillation (AF) termination by catheter ablation in patients with persistent AF has not been evaluated fully. The aim of this study was to evaluate the pre-procedural predictors of persistent AF termination by ablation associated with the possibility of reverse remodeling of the left atrium (LA). METHODS AND RESULTS: Seventy consecutive patients (mean age, 62+/-8 years) with persistent or long-standing persistent AF underwent ablation. They were divided into 2 groups: those with AF terminated by ablation (n=14; group 1) and those with AF terminated by cardioversion after ablation (n=56; group 2). The left atrial appendage (LAA) contraction velocity determined on transesophageal echocardiography was significantly decreased in group 2 as compared to group 1 (P<0.001). Kaplan-Meier analysis showed that the group 1 patients had a higher AF-free survival rate than those in group 2 during 12+/-4.1 months of follow-up (P=0.048). The LA reverse remodeling ratio, given as the volume difference between before and 3 months after ablation in group 1, was significantly greater after ablation than that in group 2 (25.8+/-13% vs. 15.0+/-15%, P=0.015). Multivariate logistic regression analysis indicated that the LAA contraction velocity was an independent predictor of persistent AF termination by ablation (P=0.018). CONCLUSIONS: The LAA contraction velocity was the only non-invasive pre-procedural predictor of persistent AF termination by ablation, indicating the possibility of reverse remodeling of the LA.  (+info)

Changes in microRNAs expression are involved in age-related atrial structural remodeling and atrial fibrillation. (2/11)

BACKGROUND: Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been implicated in the aging process and in the regulation of extracellular matrix proteins. However, their role in age-related cardiac remodeling and atrial fibrillation (AF) was not well understood. The present study was designed to decipher molecular mechanisms underlying age-related atrial structural remodeling and AF. METHODS: Three groups of dogs were studied: adult and aged dogs in sinus rhythm and with persistent AF induced by rapid atrial pacing. The expressions of microRNAs were measured by quantitative real-time polymerase chain reaction. Pathohistological and ultrastructural changes were tested by light and electron microscopy. Apoptosis index of myocytes was detected by TUNEL. RESULTS: Samples of atrial tissue showed the abnormal pathohistological and ultrastructural changes, the accelerated fibrosis, and apoptosis with aging and/or in AF dogs. Compared to the adult group, the expressions of microRNAs-21 and -29 were significantly increased, whereas the expressions of microRNAs-1 and -133 showed obvious downregulation tendency in the aged group. Compared to the aged group, the expressions of microRNAs-1, -21, and -29 was significantly increased in the old group in AF; contrastingly, the expressions of microRNA-133 showed obvious downregulation tendency. CONCLUSION: These multiple aberrantly expressed microRNAs may be responsible for modulating the transition from adaptation to pathological atrial remodeling with aging and/or in AF.  (+info)

An Angiotensin receptor blocker prevents arrhythmogenic left atrial remodeling in a rat post myocardial infarction induced heart failure model. (3/11)

 (+info)

Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing. (4/11)

 (+info)

MicroRNAs in pulmonary arterial remodeling. (5/11)

 (+info)

Left atrial endocardial fibrosis and intra-atrial thrombosis - landmarks of left atrial remodeling in rats with spontaneous atrial tachyarrhythmias. (6/11)

INTRODUCTION: Histological abnormalities are common findings in the left atria (LA) of atrial fibrillation (AF) patients. We aimed to assess LA histological abnormalities in our model of spontaneous atrial tachyarrhythmias in rats. MATERIALS AND METHODS: LA sampling was performed in 12 spontaneously hypertensive rats (SHRs) and eight age-matched Wistar-Kyoto (WKY) rats. Tissue sections were stained with Masson's trichrome and Hematoxylin-Eosin-Safran and examined with a light microscope. A 0 to 3 scoring system was used to quantify the severity of LA structural abnormalities. LA von Willebrand factor (vWF) content was also assessed using immunohistochemical staining. RESULTS: In six of the eight SHRs, LA fibrosis, inflammatory infiltrates, and myocyte necrosis of varying grades of severity were observed. The most frequent feature was endocardial fibrosis, which was observed in six SHRs and in none of the WKY rats. Intra-atrial thrombosis was found in three SHRs and in none of the WKY rats. The intensity of vWF-related fluorescence was higher in the atrial endocardium of SHRs compared to age-matched WKY rats. CONCLUSIONS: Our findings reinforce the role of LA structural abnormalities in atrial arrhythmogenicity. However, two SHRs did not present LA histological abnormalities despite the presence of arrhythmias. This finding suggests that the LA remodeling-atrial tachyarrhythmia relationship could be highly nonlinear and that atrial fibrosis is more likely to be a facilitator of atrial arrhythmogenicity, rather than a prerequisite. We also provide evidence that intra-atrial thrombosis accompanies LA structural remodeling in arrhythmic rats. Increased endocardial platelet adhesion molecule vWF could contribute to this increased thrombogenicity.  (+info)

Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation. (7/11)

 (+info)

Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing. (8/11)

 (+info)

AF is very rare in children so it would be no surprise if theres not much out there. If you want this question to remain open, you should edit it and add some of the information youve found so far because MedSci requires questions to demonstrate at least some level of prior research. - Carey Gregory♦ Nov 9 18 at 19:49 ...
TY - JOUR. T1 - Localization of atrial natriuretic peptide in normal human atrial tissue by immunoelectron microscopy. AU - Wei, Chi Ming. AU - Hukee, Margaret. AU - McGregor, Christopher G.A.. AU - Burnett, John C.. PY - 1993/12/1. Y1 - 1993/12/1. N2 - The study shows that atrial matriuretic peptide (ANP) is localized to secretory granules in normal human atrial tissue. This extends our understanding to the normal human of the biology of atrial regulation of this significant peptide of cardiac origin.. AB - The study shows that atrial matriuretic peptide (ANP) is localized to secretory granules in normal human atrial tissue. This extends our understanding to the normal human of the biology of atrial regulation of this significant peptide of cardiac origin.. UR - http://www.scopus.com/inward/record.url?scp=0027705543&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027705543&partnerID=8YFLogxK. M3 - Conference article. AN - SCOPUS:0027705543. SP - 316. EP - 317. JO - ...
Tokyo ― Terumo Corporation (TSE: 4543 Section 1) announced CE marking for the commercial sale of the Iberis™ Renal Sympathetic Denervation System, which the company has consigned product development to Shanghai AngioCare Medical Technology Co., Ltd. (hereinafter AngioCare) (Representative: Philip Wang), a Chinese company in renal sympathetic denervation technology for resistant hypertension treatment.. In December, 2012, Terumo formed a strategic alliance with AngioCare. Furthermore, the company has consigned product development to AngioCare and acquired the exclusive distribution rights for its renal sympathetic denervation technology on the global market.. Sales of Iberis in Europe will be commenced with its launch at the worlds leading cardiovascular intervention course, EuroPCR to be held in France in May, 2013.. Terumo aims to expand its renal sympathetic denervation business by launching Iberis in Asian and Latin American countries where the CE marked product is allowed for ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
The objective of this trial is to determine the efficacy and safety of adjunctive catheter-based renal sympathetic denervation (RSDN) in the primary prevention of ICD therapy in patients with ischemic or non-ischemic ventricular dysfunction, who are to receive an ICD for either i) secondary prevention, or ii) primary prevention + inducible VT by programmed ventricular stimulation at the time of ICD implantation. These patients will be randomized to ICD alone or ICD + RSDN ...
The objective of this trial is to determine the efficacy and safety of adjunctive catheter-based renal sympathetic denervation (RSDN) in the primary prevention of ICD therapy in patients with ischemic or non-ischemic ventricular dysfunction, who are to receive an ICD for either i) secondary prevention, or ii) primary prevention + inducible VT by programmed ventricular stimulation at the time of ICD implantation. These patients will be randomized to ICD alone or ICD + RSDN ...
Acupuncture Points location, description, functions, picture, acupuncture point chart. Look for specific acupuncture points and their uses. See pictures, charts and learn common uses and location.
TY - JOUR. T1 - Measurement of funny current (I(f)) channel mRNA in human atrial tissue. T2 - Correlation with left atrial filling pressure and atrial fibrillation. AU - Lai, Ling Ping. AU - Su, Ming Jai. AU - Lin, Jiunn Lee. AU - Tsai, Chang Her. AU - Lin, Fang Yue. AU - Chen, Yih Sharng. AU - Hwang, Juey Jen. AU - Stephen Huang, Shoei K.. AU - Tseng, Yung Zu. AU - Lien, Wen Pin. PY - 1999/1/1. Y1 - 1999/1/1. N2 - Introduction: The funny current (I(f)) contributes to phase IV spontaneous depolarization in cardiac pacemaker tissue. Enhanced I(f) activity in myocardial tissue may lead to increased automaticity and therefore tachyarrhythmia. We measured the amount of I(f) activity in the messenger ribonucleic acid (mRNA) in human atrial tissue and correlated the mRNA amount to left atrial filling pressure and atrial fibrillation (AF). Methods and Results: A total of 34 patients undergoing open heart surgery were included (15 men and 19 women, aged 55 ± 10 years). Atrial tissue was obtained from ...
This MATLAB function displays the vectors specified by U and V, where U contains the x components as relative coordinates, and V contains the y components as relative coordinates.
Full nutritional breakdown of the calories in Microwave Peanut Brittle based on the calories and nutrition in each ingredient, including Peanuts, dry-roasted, Granulated Sugar, Light Corn Syrup, Butter, salted, Vanilla Extract and the other ingredients in this recipe.
In this monograph Dr. Wenger has reviewed some 800 cases of endocardial fibro-elastosis from the literature and has reported 40 cases of his own. The result of his labors is a useful collection of data and references dealing with this poorly understood disorder. The author distinguishes five types of endocardial fibrotic change and divides his material therefore into these five major categories: (1) Endocardial fibro-elastosis, (2) Endomyocardial fibrosis, (3) Endocarditis parietalis fibroplastica, (4) Endocardial changes in the carcinoid syndrome, and (5) Secondary patchy endocardial fibrosis of the adult.. Irrespective of the validity of this division, these headings allow the author ...
Blood flow measurement using an improved surface integration of velocity vectors (SIVV) technique was tested in in vitro phantoms. SIVV was compared with true flow (12-116 mL/s) in a steady-state model using two angles of insonation (45 degrees and 60 degrees ) and two vessel sizes (internal diameter = 11 and 19 mm). Repeatability of the method was tested at various flow rates for each angle of insonation and vessel. In a univentricular pulsatile model, SIVV flow measured at the mitral inlet was compared to true flow (29-61 mL/s). Correlation was excellent for the 19-mm vessel (r(2)= 0.99). There was a systematic bias but close limits of agreement (mean +/- 2 SD = -24.1% +/- 7.6% at 45 degrees; +16.4% +/- 11.0% at 60 degrees ). Using the 11-mm vessel, a quadratic relationship was demonstrated between between SIVV and true flow (r(2) = 0.98-0.99), regardless of the angle of insonation. In the pulsatile system, good agreement and correlation were shown (r(2) = 0.94, mean +/- 2 SD = -4.7 +/- ...
In a preferred embodiment, drugs having heretofore unknown pharmacological properties which are useful in the medicinal therapy of fibrotic disease for the reparation and prevention of fibrotic lesional tissues, such drugs including as the active ingredient 5-methyl-1-phenyl-2-(1H)-pyridone. The pharmaceutical composition of this invention is novel as an anti-fibrotic drug, namely, as an agent for treating fibrosis. Any existing compounds have not been shown to be effective for the reparation and prevention of fibrotic lesions.
You are definitely on the right track. You can continue by first combining terms on the velocity so that you have the results in the form ai+bj+ck. The rate at which work is being done at any time is equal to the force F dotted with the velocity vector. Evaluate this dot product, and then integrate with respect to t. What is the formula for the change in KE in terms of the initial and the final velocity ...
Symple Surgical Inc., (SSI) is a developer of novel ablation technologies using controlled Microwave Energy. Symple Surgical innovation is for the treatment of resistant hypertension via renal sympathetic denervation. The DirectAblate Catheter delivers microwave energy to the depth-specific location of the sympathetic nerves while minimizing thermal exposure to non-targeted areas. Offices located in Northern California and Flagstaff, AZ.
TY - JOUR. T1 - Assessment of brachial artery mechanics using velocity vector imaging does not predict arteriovenous fistula failure; A feasibility study. AU - MacDonald, Conor James. AU - Ross, Rose. AU - Houston, John Graeme. PY - 2020/4/10. Y1 - 2020/4/10. N2 - Strain measurements by US have been suggested as a method of assessing arterial elasticity prior to arterio venous fistula creation. This pilot study sought to develop an imaging protocol to measure strain in the brachial artery via velocity vector imaging (VVI) and determine if differences in strain could be observed between a healthy group and a group with end-stage renal disease (ESRD), and if VVI measurements were associated with arterio-venous fistula malfunction. 40 healthy volunteers and 33 patients with ESRD were included in this study. All participants underwent US assessment of brachial artery strain via VVI. Peak velocity, strain, strain-rate and velocity were assessed. Patients with and without AVF failure at 3-months were ...
well, I found an equation of a= (v^2)/2 i, which gave an acceleration of a = 8 m/s i. I dont understand how this equation was derived. Although, now that I have actually thought about this, the acceleration vector around a curve or a circle always points toward the center of the circle and the velocity vector is always tangent to the point on the curve, so I understand how the acceleration vector is i and the velocity vector is j for x=-2,y=0. The only problem I have is the equation I came across ...
A method of controlling scar formation in humans by applying a force to tissue in an amount to create a wound; applying a lathyrogenic agent to the wound; forming the wound into a predetermined stationary or moveable beneficial configuration; and maintaining the wound in the predetermined configuration and in contact with lathyrogenic agent during healing.
Session VI - Recognizing Grey - controversial and ambiguous issues in cardiology. Chairpersons: J. J. Bax (Leiden, NL). B. Khandheria (Milwaukee, WI USA). 11:00 a.m. K. Narkiewicz (Gdańsk, PL). Hidden mechanisms of arterial hypertension. 11:30 a.m. J. J. Bax (Leiden, NL). Imaging to select patients for TAVI. 12:00 p.m. S. Q. Allaqaband (Milwaukee, WI USA). Interventions in structural heart disease. 12:30 p.m. F. Mahfoud (Homburg, D). Renal sympathetic denervation: should we go beyond resistant hypertension?. 01:00 p.m. M. Miglinas (Vilnius, LT). Blood pressure lowering and target organ protection: coherent or diverging effects?. 01:30 p.m. Concluding Remarks. Remigijus Zaliunas (Kaunas, LT). Rimvydas Slapikas (Kaunas, LT). Germanas Marinskis (Vilnius, LT). Zaneta Petrulioniene (Vilnius, LT ...
carbon dioxide angiography, chronic kidney disease (CKD), contrast nephropathy, renal sympathetic denervation, uncontrolled hypertension Background
Definition and Overview A keloid is a skin disorder subsequent from an abnormal or unnecessary development of scar tissue after a deep injury or wound has healed. It is a dermal fibrotic lesion ...
Study Flashcards On 6-04 msk/derm/vasc at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Identification of discrete surfaces. A: whole cardiac mesh [including atrial tissue] produced from Tetgen showing the tagged tetrahedral elements: myocardium (g
Since 2012, several cases of renal stenosis after renal denervation have been reported, demonstrating a wide spectrum of clinical presentation, but presenting recurrent hypertension as most relevant finding (1).. In the previous trials HTN-1 (Symplicity Renal Denervation in Patient With Refractory Hypertension) (2) and EnligHTN-I (Safety and Efficacy of Study of Renal Artery Ablation in Resistant Hypertension Patients) (3), renal artery stenosis had been attributed mainly to pre-existing artery stenosis worsening and not to a de novo procedure-related adverse event. The increasing reports of the last call into question the safety of this procedure and point to this complication as a possible cause of therapy ineffectiveness. ...
Methods and Results: We used a human atrial tissue model in heart failure and simulated propagation and spiral wave reentry with and without regionally proliferated fibroblasts. Coupling of fibroblasts to atrial myocytes resulted in shorter action potential duration, slower conduction velocity, and lower excitability. Consequently, heterogeneous fibroblast proliferation in the myocardial sheet resulted in frequent spiral wave breakups, and the bipolar electrograms recorded at the fibroblast proliferation area exhibited CFAEs. The simulations demonstrated that ablation targeting such fibroblast-derived CFAEs terminated AF, resulting from the ablation site transiently pinning the spiral wave and then pushing it out of the fibroblast proliferation area. CFAEs could not be attributed to collagen accumulation alone.. ...
Coarctation of the aorta is a narrowing of the descending aorta, which is typically located at the insertion of the ductus arteriosus just distal to the left subclavian artery (). This defect generally results in left ventricular pressure overload.Th
"Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs". ... In a porcine model of left atrial remodeling following mitral regurgitation, VLC-2 was shown to be upregulated. Human ALC-2 is ... Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans ... In a canine model of atrial fibrillation, decreased atrial contractility was associated with decreased ALC-2 and myosin binding ...
These thickenings will go on to fuse and remodel to eventually form the valves and septa of the mature adult heart. A problem ... Upon sectioning of the heart the atrioventricular endocardial cushions can be observed in the lumen of the atrial canal as two ... As heart development continues, this tube undergoes remodeling to eventually form the four-chambered heart. The endocardial ... in endocardial cushion development or remodeling is thought to be associated with atrioventricular septal defect. Endocardial ...
"Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy". Nature. 484 (7393): 246-50. Bibcode: ... Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac ... These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood ... ANP is secreted in response to: Stretching of the atrial wall, via Atrial volume receptors Increased Sympathetic stimulation of ...
"Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovasc. Res. 83 (3): ...
pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ... Throughout life, the cardiac collagen skeleton is remodeled. Where collagen is diminished by age, calcium is often deposited, ... venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... The AV node is the only electrical conduit from the atria to the ventricles through the cardiac skeleton, which is why atrial ...
Atrial septostomy. Balloon septostomy. creation of septal defect in heart Blalock-Hanlon procedure. shunt from heart chamber to ... They also decrease cardiac oxygen demand and can prevent cardiac remodeling. Not all beta blockers are the same; some are ... including atrial fibrillation and atrial flutter. It is also used in the emergent treatment of wide complex tachycardias, ... It has been shown to be effective in acute cardioversion of recent-onset atrial fibrillation and atrial flutter. ...
... which leads to atrial remodeling and fibrosis, with loss of atrial muscle mass. This process occurs gradually, and experimental ... Valvular atrial fibrillation refers to atrial fibrillation attributable to moderate to severe mitral valve stenosis or atrial ... left atrial volume, size, and left ventricular hypertrophy, characteristic of chronic hypertension. All atrial remodeling is ... 193,300 with atrial flutter (2015)[10]. Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm (arrhythmia) ...
Veno-occlusive remodelling[edit]. This theory proposes how high pulmonary venous pressures may lead to the capillary rupture ... pulmonary infection or atrial fibrillation, inflammation, longer distances, longer duration of exercise, hard surfaces, ... Other histopathologic findings include fibrosis, bronchial artery neovascularization, venous remodeling, bronchiolitis, ... with the venous remodeling leading to regional vascular congestion and hemorrhage, hemosiderin accumulation, fibrosis, and ...
... and remodeling after repeated challenge". American Journal of Respiratory Cell and Molecular Biology. 35 (3): 366-77. doi: ... "Pirfenidone prevents the development of a vulnerable substrate for atrial fibrillation in a canine model of heart failure". ...
One reason for this may be that once the heart has undergone atrial remodeling as in the case of chronic atrial fibrillation ... AF therefore have an increased chance of success with an ablation since their heart has not undergone atrial remodeling yet. ... For atrial fibrillation, several experienced teams of electrophysiologists in US heart centers claim they can achieve up to a ... Risks of catheter ablation for atrial fibrillation include, but are not limited to: stroke, esophageal injury, pulmonary vein ...
... reducing atrial contractility and potentially contributing to atrial fibrillation.[25] Structural changes in T-tubules can lead ... as some suggest that T-tubule remodelling might be reversed through the use of interval training.[5] ... T-tubules are found in both atrial and ventricular cardiac muscle cells (cardiomyocytes), in which they develop in the first ... in 2009 an extensive T-tubule network in atrial cardiac muscle cells was observed.[25] Ongoing research focusses on the ...
This process is commonly called remodelling. However, osteoporosis is essentially the result of a lack of new bone formation in ... since it is the only gene known to be associated with bone abnormalities and atrial fibrillation, both of which are side ... Parfitt AM (1994). "Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human ... Frost HM (1963). Bone Remodeling Dynamics. Springfield, IL: Charles C. Thomas. Owen M; Friedenstein AJ (1988). "Stromal stem ...
These effects directly act together to increase blood pressure and are opposed by atrial natriuretic peptide (ANP). ... implications in cardiovascular remodeling". Current Opinion in Nephrology and Hypertension. 17 (2): 168-73. doi:10.1097/MNH. ... it may be involved in remodeling or vascular tone; and in the brain, where it is largely independent of the circulatory RAS, it ...
Central venous pressure, which is a good approximation of right atrial pressure,[35] which is a major determinant of right ... In the longer term a process termed remodeling also contributes to changing the caliber of small blood vessels and influencing ... Mulvany, Michael J. (2012). "Small artery remodelling in hypertension". Basic & Clinical Pharmacology & Toxicology. 110 (1): 49 ... Tkachenko BI, Evlakhov VI, Poyasov IZ (2002). "Independence of changes in right atrial pressure and central venous pressure". ...
Left atrial dimension. LA. Range 24 - 40 mm[16] Fractional shortening (FS) is the fraction of any diastolic dimension that is ... pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ... venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... dimensions and relaxation in patients with atrial fibrillation". European Heart Journal. Suppl A: 149-56. PMID 7274225.. ...
A simplified form of this equation assumes right atrial pressure is approximately 0: CO ≈ MAP/TPR. The ideal blood pressure in ... RAP = right atrial pressure (in mmHg), the average pressure of blood as it returns to the heart ...
However, as the atrial baroreceptors increase their rate of firing and as they stretch due to the increased blood pressure, the ... There is a similar reflex, called the atrial reflex or Bainbridge reflex, associated with varying rates of blood flow to the ... This is important mainly in patients with atrial fibrillation, in whom heart beats are irregular and stroke volume is largely ...
Practical Guide to Catheter Ablation of Atrial Fibrillation (2nd ed.). Wiley-Blackwell. pp. 65-73. ISBN 9781118658505.. .mw- ... "Ablation therapy for atrial fibrillation (AF): past, present and future". Cardiovascular research. 54 (2): 337-46. PMID ...
... is the passage of fluid through the circulatory system or lymphatic system to an organ or a tissue,[1] usually referring to the delivery of blood to a capillary bed in tissue. Perfusion is measured as the rate at which blood is delivered to tissue,[2] or volume of blood per unit time (blood flow) per unit tissue mass. The SI unit is m3/(s·kg), although for human organs perfusion is typically reported in ml/min/g.[3] The word is derived from the French verb "perfuser" meaning to "pour over or through".[4] All animal tissues require an adequate blood supply for health and life. Poor perfusion (malperfusion), that is, ischemia, causes health problems, as seen in cardiovascular disease, including coronary artery disease, cerebrovascular disease, peripheral artery disease, and many other conditions. Tests verifying that adequate perfusion exists are a part of a patient's assessment process that are performed by medical or emergency personnel. The most common methods include evaluating a ...
Atrial fibrillation and atrial flutter without rapid ventricular response. *Premature atrial contraction (PACs) and premature ... Atrial septostomy. Balloon septostomy. creation of septal defect in heart Blalock-Hanlon procedure. shunt from heart chamber to ... can indicate an ectopic atrial pacemaker. If the P wave is of unusually long duration, it may represent atrial enlargement. ... Atrial depolarization spreads from the SA node towards the AV node, and from the right atrium to the left atrium. The P wave is ...
displaystyle {\frac {80\cdot (mean\ arterial\ pressure-mean\ right\ atrial\ pressure)}{cardiac\ output}}}. where mean arterial ... As an example: If Systolic pressure: 120 mmHg, Diastolic pressure: 80 mmHg, Right atrial mean pressure: 3 mmHg, Cardiac output ... and the pressure downstream from the occlusion is measured in order to approximately sample the left atrial pressure.[4] ...
The mechanism that leads to vasoconstriction results from the increased concentration of calcium (Ca2+ ions) within vascular smooth muscle cells.[2] However, the specific mechanisms for generating an increased intracellular concentration of calcium depends on the vasoconstrictor. Smooth muscle cells are capable of generating action potentials, but this mechanism is rarely utilized for contraction in the vasculature. Hormonal or pharmacokinetic components are more physiologically relevant. Two common stimuli for eliciting smooth muscle contraction are circulating epinephrine and activation of the sympathetic nervous system (through release of norepinephrine) that directly innervates the muscle. These compounds interact with cell surface adrenergic receptors. Such stimuli result in a signal transduction cascade that leads to increased intracellular calcium from the sarcoplasmic reticulum through IP3-mediated calcium release, as well as enhanced calcium entry across the sarcolemma through calcium ...
... is the study of the cardiovascular system, specifically addressing the physiology of the heart ("cardio") and blood vessels ("vascular"). These subjects are sometimes addressed separately, under the names cardiac physiology and circulatory physiology.[1] Although the different aspects of cardiovascular physiology are closely interrelated, the subject is still usually divided into several subtopics. ...
Intracellular calcium (Ca2+) concentration exhibits periodic oscillations in vascular smooth muscle cells. This is thought to result from Ca2+ release from intracellular stores, due to inositol triphosphate and ryanodine-sensitive channel activation. This activation has been shown to result in either Ca2+ "sparks", highly localized calcium increases, or "waves", global Ca2+ increase that propagates the length of the cell.[3] To allow vasomotion to occur, synchronization must occur between the individual oscillations, resulting in global calcium synchronization and vessel tone oscillation.[4] Gap junctions are thought to play a large role in this synchronization, as application of gap junction blockers has been shown to abolish vasomotion, indicating a critical role.[5] Due to regional variations in gap junction distribution and coupling (homocellular vs. heterocellular) several hypotheses have been suggested to account for vasomotion occurrence. The "classic" mechanism of vasomotion generation ...
pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ... Further development will include the septa and valves formation and remodelling of the heart chambers. By the end of the fifth ... venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... A fourth heart sound S4 is referred to as an atrial gallop and is produced by the sound of blood being forced into a stiff ...
For the treatment of atrial fibrillation, it is a problem that the prolongation of the ERP by these agents also affects the ...
... coming from pig small intestine submucosa are being used to repair "atrial septal defects" (ASD), "patent ... Bonnans C, Chou J, Werb Z (December 2014). "Remodelling the extracellular matrix in development and disease". Nature Reviews. ... Although the mechanism of action by which extracellular matrix promotes constructive remodeling of tissue is still unknown, ... "Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling". ...
The P wave in the ECG represents atrial depolarization, which results in atrial contraction, or atrial systole. ... atrial rhythm if the rate is ≤100) or multifocal atrial tachycardia if the rate is over 100.[6] This appears particularly ... Atrial repolarization[edit]. This occurs a mean of 320 ms after the end of the P wave, with a duration of 2-3 times that of the ... Peaked P waves (, 0.25 mV) suggest right atrial enlargement, cor pulmonale, (P pulmonale rhythm),[1] but have a low predictive ...
Atrial systole[edit]. Main article: Systole § Atrial systole. Atrial systole is the contracting of cardiac muscle cells of both ... such as caused by atrial fibrillation, atrial flutter, or heart block. Atrial kick may also be degraded by any deterioration in ... 2b Inflow: (Ventricular filling with Atrial systole#) open. closed. • ventricles relaxed and expanded; atrial contraction ( ... the atrial systole applies contraction pressure to 'topping-off' the blood volumes sent to both ventricles; this atrial kick ...
... causing structural remodelling of the heart over the long term. Many of these remodelling effects seem to be mediated by ... It is now used in only a small number of people with refractory symptoms, who are in atrial fibrillation and/or who have ... atrial fibrillation, valvular heart disease, excess alcohol use, infection, and cardiomyopathy of an unknown cause.[2][3] These ... people with coexisting atrial fibrillation, a prior embolic event, or conditions which increase the risk of an embolic event ...
The difference between aortic and right atrial pressure accounts for blood flow in the circulation.[16] When the left ventricle ... and then undergo a significant remodelling[11] to form the final asymmetrical structure of the great arteries, with the 3rd ...
With support from collagen, atrial fibrillation should never deteriorate to ventricular fibrillation. Collagen is layered in ... Collagenase, the enzyme involved in collagen breakdown and remodeling. *Hypermobility syndrome. *MMP inhibitors ...
Meinertz T, Willems S (December 2008). "[Treatment of atrial fibrillation in every days practice]" [Treatment of atrial ... and abnormal cardiac tissue remodeling, all of which decrease the efficiency of cardiac contraction and contribute to the low ... and prolonged atrial refractory periods. Sotalol, in particular, has additional antiarrhythmic properties and prolongs action ...
Atrial fibrillation, other cardiac arrhythmias, or sudden cardiac death[5]. Heart failure can develop insidiously over time or ... Left ventricular hypertrophy and left ventricular remodeling[5]. *Diminished coronary flow reserve and silent myocardial ... Atrial fibrillation or other disorders of cardiac rhythm due to other causes ... "2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial ...
Atrial fibrillation - Atrial flutter - Premature contraction (Atrial, Ventricular) - Sick sinus syndrome. ... Ventricular remodeling. Dalerayan[mag-edit , alilan ya ing pikuwanan]. *↑ (2004) The World Health Report 2004 - Changing ...
Atrial *Septum primum. *Foramen secundum. *Primary interatrial foramen. *Septum secundum. *Foramen ovale ...
... and more recently as management of atrial fibrillation. The term is often used in the context of laser ablation, a process in ... laser is used to remodel the cornea refractive properties to correct refraction errors, such as astigmatism, myopia, and ...
See also: Atrial natriuretic peptide. REST/NRSF in conjunction with RE1/NRSE also acts outside the nervous system as regulators ... Current research has linked RE1/NRSE activity with the regulation of the expression of the atrial natriuretic peptide (ANP) ... Neuron-Restrictive Silencer Element-Neuron-Restrictive Silencer Factor System Regulates Basal and Endothelin 1-Inducible Atrial ...
Tan NY, Leong YY, Lang SS, Htoon ZM, Young SM, Sundar G (May 2017). "Radiologic Parameters of Orbital Bone Remodeling in ... George H. W. Bush, former U.S. president, developed new atrial fibrillation and was diagnosed in 1991 with hyperthyroidism due ... and progressive remodeling of the orbital walls.[21][22][23] Other distinctive features of TAO include lid retraction, ... atrial fibrillation), which may lead to stroke. If the eyes are proptotic (bulging) enough that the lids do not close ...
Central venous pressure/right atrial pressure → Right ventricular pressure → Pulmonary artery pressure → Pulmonary wedge ... pressure/left atrial pressure → Left ventricular pressure → Aortic pressure. Other. *Ventricular remodeling ...
... coming from pig small intestine submucosa are being used to repair "atrial septal defects" (ASD), "patent ... Although the mechanism of action by which extracellular matrix promotes constructive remodeling of tissue is still unknown, ... "Remodelling the extracellular matrix in development and disease". Nature Reviews. Molecular Cell Biology. 15 (12): 786-801. ... "Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling" ...
blood vessel remodeling. • cellular response to hypoxia. • heart valve development. • cellular response to estrogen stimulus. • ... atrial septum development. • regulation of heart rate. • DNA damage response, signal transduction by p53 class mediator ...
"Radiologic Parameters of Orbital Bone Remodeling in Thyroid Eye DiseaseOrbital Bone Remodeling in Thyroid Eye Disease". ... George H. W. Bush, former U.S. president, developed new atrial fibrillation and was diagnosed in 1991 with hyperthyroidism due ... and progressive remodeling of the orbital walls.[19][20][21] Other distinctive features of TAO include lid retraction, ... atrial fibrillation), which may lead to stroke. If the eyes are proptotic (bulging) enough that the lids do not close ...
Sullivan ML, Martinez CM, Gallagher EJ (1999). "Atrial fibrillation and anabolic steroids". The Journal of emergency medicine. ... increased bone remodeling and growth, and stimulation of bone marrow, which increases the production of red blood cells. ...
Atrial stretch induced by increased atrial pressure may precipitate atrial fibrillation through some effect on atrial ... Thus, it is possible that the elevation of atrial pressure might cause electrical remodeling by the upregulation of atrial AT1 ... However, long-term rapid atrial pacing might be necessary to examine the time course of atrial electrical remodeling and the ... Therefore, we continued rapid atrial pacing for 3 hours, which was enough to evaluate acute atrial electrical remodeling. In ...
... and such a remodeling has also been called atrial tachycardia remodeling.1,2,42,43 Atrial tachycardia remodeling is suggested ... Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to ... Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial- tachycardia remodeling in dogs. ... Background-A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated ...
During atrial fibrillation atrial remodeling takes place. Atrial remodeling refers to changes in the atria, including ... The aim of this thesis was to investigate this atrial remodeling. The focus is on remodeling caused by stretch (mimicking these ... First, different aspects of structural atrial remodeling are reviewed with a special focus on stretch and its contribution to ... Atrial fibrillation is the most common cardiac arrhythmia. Risk factors for atrial fibrillation include older age, hypertension ...
Left atrial (LA) enlargement is a common finding in hypertensive patients (pts), however little information is available on LA ... OBJECTIVES: Left atrial (LA) enlargement is a common finding in hypertensive patients (pts), however little information is ... hypertension showed a more marked increased of LA volumes compared to gestational hypertension due to a remodeling of atrial ...
... causes tachycardia-induced atrial electrical remodeling, contributing to the progressive nature of the arrhythmia. Ventricular ... dysfunction due to a rapid response to AF can cause structural remodeling, but whether ... OBJECTIVE: Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling, contributing to the progressive ... Atrial tissue from 1-week atrial-tachypaced dogs with ventricular rate control similarly showed upregulation of alpha SMA ...
... levels predict left atrial reverse remodeling after catheter ablation in patients with atrial fibrillation (AF) ... HealthDay News - Preprocedural serum atrial natriuretic peptide (ANP) levels predict left atrial reverse remodeling after ... "In this study, 47% of the patients exhibited left atrial reverse remodeling after RFCA for AF, with a concomitant improvement ... before RFCA and maintenance of sinus rhythm during follow-up were independent predictors of left atrial reverse remodeling ( ...
... cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial ... either of atrial or of ventricular origin, remains a major challenge. Sudden ... Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias. ... The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden ...
Thrombin promotes premature ageing and senescence of atrial ECs and may pave the way to deleterious remodeling of atrial tissue ... pro-fibrotic and pro-remodeling responses. Hence, targeting thrombin and/or angiotensin systems may efficiently prevent atrial ... Atrial endothelial senescence was induced by thrombin at clinically relevant concentrations. Thrombin induced the up-regulation ... We examined the potential of thrombin to promote premature atrial endothelial cells (ECs) senescence. Methods and Results: ...
Measurement of left atrial (LA) volume by the biplane area-length method where A2Ch and A4Ch refer to the LA area in the two- ... Background Left atrial (LA) size is an adverse prognostic marker. Aortic stenosis results in increased filling pressures with ... progressive left atrial enlargement and dysfunction. Intervention for aortic stenosis results in LV reverse remodelling, ...
... few data are available describing factors influencing changes in left atrial (LA) structure.Methods and Results-Maximum LA ... Background-Although contributors to remodeling of the left ventricle (LV) have been well studied in general population cohorts ... Background-Although contributors to remodeling of the left ventricle (LV) have been well studied in general population cohorts ... Associations of changes in LA volume (ΔLAV) with traditional risk factors, biomarkers, LV geometry, and remodeling by cardiac ...
Atrial Fibrillation. Atrial Remodeling. Vascular Diseases. Cardiovascular Diseases. Arrhythmias, Cardiac. Heart Diseases. ... Structural Remodeling (left atrial volume, left. *ventricular mass, left ventricular diastolic function. Evaluated at ... Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and ... Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension, Permanent ...
Atrial natriuretic peptide (ANP) reduces pulmonary vascular resistance and attenuates hypoxia-induced pulmonary hypertension in ... Measurement: pulmonary hypertension, right ventricular hypertrophy, and pulmonary arterial and alveolar remodeling were ... to test the hypothesis that ANP modulates the pulmonary vascular and alveolar remodeling response to normobaric hypoxic stress ... resulting in pulmonary vascular remodeling characterized by hyperplasia of pulmonary arterial smooth muscle cells (PASMCs) and ...
Defining biological markers of atrial remodelling would help identify patients at high risk who would benefit most from ... Biomarkers of atrial fibrillation progression would be helpful for following patients that present with asymptomatic atrial ... Notably, the roles of such markers in the pathophysiology of atrial fibrillation must be determined. Some markers may indicate ... Although a number of markers have been reported as potential predictors of paroxysmal atrial fibrillation progression towards ...
Atrial fibrillation begets atrial fibrillation: autonomic mechanism for atrial electrical remodeling induced by short-term ... seem to play a more relevant role for atrial electrical remodeling during AF. Atrial electrical remodeling results mainly from ... Renal Sympathetic Denervation Provides Ventricular Rate Control But Does Not Prevent Atrial Electrical Remodeling During Atrial ... Renal Sympathetic Denervation Provides Ventricular Rate Control But Does Not Prevent Atrial Electrical Remodeling During Atrial ...
1999) Promotion of atrial fibrillation by heart failure in dogs Atrial remodeling of a different sort. Circulation, 100, 87-95 ... 1999) Promotion of atrial fibrillation by heart failure in dogs: Atrial remodeling of a different sort. Circulation, 100, 87-95 ... symptomatic atrial fibrillation and heart failure. Randomized studies and observational data suggest that atrial fibrillation ... TITLE: Atrial fibrillation ablation in patients with heart failure review. AUTHORS: Mohammad I. Amin, Laurence D. Sterns, ...
Whether increased MMP activity directly contributes to atrial remodeling and AF in the setting of HF remains unclear. The ... play a role in extracellular remodeling, and recent studies have demonstrated increased atrial MMP activity in HF. ... The SAVP-MMPi dogs had significantly smaller increases in atrial myocyte cross sectional area, collagen area fraction, and MMP- ... current study examined the effects of MMP inhibition on atrial structural remodeling and AF vulnerability during HF progression ...
Background The contribution of progressive left atrial (LA) enlargement to elevated pulmonary capillary wedge pressure (PCWP) ... Association of echocardiographic atrial size and atrial fibrosis in a sequential model of congestive heart failure and atrial ... Effects of quinapril on left atrial structural remodeling and arterial stiffness. Am J Cardiol. 2006;97(6):916-20.CrossRef ... Contribution of the left atrial remodeling to the elevated pulmonary capillary wedge pressure in patients with WHO Group II ...
Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation. 1999;100:87-95. ... Electrical remodeling of the human atrium: similar effects in patients with chronic atrial fibrillation and atrial flutter. J ... Reverse atrial electrical remodelling following atrial defibrillation as determined by signal-averaged ECG. Can J Cardiol. 2004 ... Relevance of Electrical Remodeling in Human Atrial FibrillationClinical Perspective. Results of the Asymptomatic Atrial ...
... worlds leading medical scientists to share in a highly interactive environment the most recent advances in the field of atrial ... ionic remodeling and atrial fibrosis. Atrial fibrosis itself adds back to this, and results in persistent atrial fibrillation. ... Impact of atrial remodeling on AF outcomes 2013-10-01 Marking the very first presentation of the 2015 AF Symposium, Prashanthan ... Left atrial pressure and pulmonary artery pressure increased, and left atrial size increased, although the animals were too big ...
Nattel S, Burstein B, Dobrev D. Atrial remodelling and atrial fibrillation: mechanisms and implications. Circ Arrhythmia ... ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes; Cardiovasc Res. 2007 Oct 26; [ ... Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circ ... ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res. 2008; 77: 35- ...
Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs ... Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation. Publication. ... atrial fibrillation, mitochondria, MCU, Ru360, SS31 Persistent URL. dx.doi.org/10.3390/cells8101202, hdl.handle.net/1765/122262 ... Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation. Cells, 8(10). ...
Left atrial remodelling in patients with successful percutaneous mitral valvuloplasty: determinants and impact on long-term ... Left atrial remodelling in patients with successful percutaneous mitral valvuloplasty: determinants and impact on long-term ... Background Left atrial (LA) volume is an independent prognosticator in various cardiac diseases. The authors assessed the ... the presence of atrial fibrillation and post-PMV LA volume. On multiple regression analysis, pre-PMV LA volume and percentage ...
Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation: Data of the RACE II ( ... Is lenient rate control associated with more adverse cardiac remodeling than strict rate control in patients with atrial ... Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation: Data of the RACE II ( ... It is possible that adverse remodeling would have occurred in this group if the resting rate had been closer to 110 bpm, ...
... remodeling and fibrosis in paroxysmal atrial fibrillation (AF) using speckle tracking echocardiography (STE) based on the ... This study aimed to evaluate left atrial (LA) ... Assessment of left atrial remodeling in paroxysmal atrial ... Hong J, Gu X, An P, Luo T, Lv Q, Kang J, He Y, Hu R, Liu X, Ma C (2013) Left atrial functional remodeling in lone atrial ... Li D, Fareh S, Leung TK, Nattel S (1999) Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a ...
... induced atrial structural and electrical remodeling and contributes to AF perpetuation. BACKGROUND Galectin-3 (Gal-3) mediates ... The Gal-3 inhibitor GM-CT-01 (GMCT) reduced both Gal-3 and TGF-β1-induced sheep atrial fibroblast migration and proliferation ... and also mitigated atrial dilatation, myocyte hypertrophy, fibrosis, and the expected increase in dominant frequency of ... intracardiac serum Gal-3 levels were greater in persistent than paroxysmal AF and independently predicted atrial ...
RAA = right atrial appendage; RAFW = right atrial free wall; LAA = left atrial appendage; LAFW = left atrial free wall. ... of the right atrial appendage and intra-atrial conduction time (CT) from the right atrial appendage to the lower right atrial ... 1999) Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation 100:87-95. ... 2002) Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure. Cardiovasc Res ...
Serial monitoring of reverse left-atrial remodeling after pulmonary vein isolation in patients with atrial fibrillation: A ... Download PDF Serial monitoring of reverse left-atrial remodeling after pulmonary vein isolation in patients with atrial ... Serial monitoring of reverse left-atrial remodeling after pulmonary vein isolation in patients with atrial fibrillation: A ... PURPOSE: To prospectively determine the impact of sinus rhythm restoration on left-atrial (LA) volumes and function assessed by ...
LA electrical and structural remodeling leads to rhythm disorders such as atrial ectopic beats and atrial fibrillation (AF) (18 ... 2013) Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing ... Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial ... left atrial volume index. LVMI. left ventricular mass index. PAC. premature atrial contractions. proBNP. pro-brain natriuretic ...
Electrical Remodeling of the Human Atrium: Similar Effects in Patients With Chronic Atrial Fibrillation and Atrial Flutter ... Electrical Remodeling of the Human Atrium: Similar Effects in Patients With Chronic Atrial Fibrillation and Atrial Flutter ... Electrical Remodeling of the Human Atrium: Similar Effects in Patients With Chronic Atrial Fibrillation and Atrial Flutter ... and atrial flutter in patients lead to electrical remodeling of the human atrial myocardium, manifested by an abnormal relation ...
We sought to determine the link between atrial fibrillation (AF) and plasma CatK levels and to investigate the expression of ... Angiotensin type 1 receptor antagonist appears to be effective in alleviating atrial fibrosis in a rabbit AF model, partly ... CatK was correlated with ICTP concentration and left atrial diameter in all subjects. In rabbits, superoxide production, CatK ... activity, fibrosis, and the levels of atrial tissue angiotensin II, angiotensin type 1 receptor, gp91phox, phospho-p38 mitogen- ...
  • Pedersen et al 6 observed that ACEI reduced the incidence of atrial fibrillation in patients with left ventricular dysfunction after acute myocardial infarction, but they did not show the underlying mechanism of their finding. (ahajournals.org)
  • Ventricular dysfunction due to a rapid response to AF can cause structural remodeling, but whether AF itself directly promotes atrial fibrosis is controversial. (biomedsearch.com)
  • The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. (frontiersin.org)
  • Measurement: pulmonary hypertension, right ventricular hypertrophy, and pulmonary arterial and alveolar remodeling were assessed. (ovid.com)
  • The effect of modulation of the autonomic nervous system by RDN on atrial electrophysiology and ventricular rate control during atrial fibrillation (AF) is unknown. (ahajournals.org)
  • Subsequently, we investigated the effect of RDN on AF-induced shortening of atrial effective refractory period, AF inducibility, and ventricular rate control during AF maintained by rapid atrial pacing in 12 pigs undergoing RDN (n=7) or sham procedure (n=5). (ahajournals.org)
  • Atrial fibrilla- tion ablation is relatively safe and may result in improvement of left ventricular function and quality of life. (scirp.org)
  • Going back to Dr Nattel's work with substrates in AF, he continued: "This is the ventricular pacing model of heart failure, where they were able to show that in the atria there is an increased amount of atrial fibrosis associated with conduction heterogeneity, and increase of the duration of atrial fibrillation. (afsymposium.com)
  • Most are distinguished by spontaneous beating, exhibiting a wide range of depolarization-repolarization patterns, potentially indicating mixed populations of atrial and ventricular myocytes . (news-medical.net)
  • Which is more important: atrial or ventricular myocytes? (news-medical.net)
  • The muscular walls of the heart, also known as the myocardium, are formed from atrial and ventricular cardiomyocytes. (news-medical.net)
  • Differences can be seen in atrial myocyte ultrastructure when compared to ventricular myocytes. (news-medical.net)
  • Atrial and ventricular cardiomyocytes have differential gene expression patterns concerning, for example, transcription factors, structural proteins, and ion channels. (news-medical.net)
  • Additionally, they exhibit specific functions, as seen in Table 1, and highly homogeneous atrial- and ventricular-like myocytes are very helpful for drug safety, cardiac evaluation, and heart infarction cell therapies. (news-medical.net)
  • Differential gene expression pattern displays in atrial and ventricular cardiomyocytes. (news-medical.net)
  • Although there are effective therapies available for common disorders of atrial cardiomyocytes, like atrial fibrillation, loss of ventricular cardiomyocytes as a result of myocardial infarction is unable to be successfully treated. (news-medical.net)
  • Recent research using the atria of zebrafish suggests that the activation of Notch signa-ling as a response to ventricle ablation is essential for the reprogramming of atrial cardiomyocytes into ventricular cardiomyocytes. (news-medical.net)
  • It is proposed from this study that heart regeneration in zebrafish can be attained by transdifferentiation of differentiated atrial cardiomyocytes into ventricular cardiomyocytes. (news-medical.net)
  • A detailed understanding of the molecular and functional variances between atrial and ventricular cardiomyocytes is helpful in defining novel techniques for applications of embryonic stem cells (ESCs), as well as providing cellular models for research into genetic atrial- or ventricular-related diseases. (news-medical.net)
  • It is possible to use the programmed differentiation of atrial- and ventricular-like myocytes for the development of safe cell sources for individual treatment and cardiac repair that is personalized. (news-medical.net)
  • An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. (google.es)
  • The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling. (google.es)
  • 3 The method of claim 1 further comprising changing the ventricular pacing site in accordance with activity level measurements reflective of metabolic demand so that the pacing site is alternated between one designed to produce hemodynamically more effective contractions when metabolic needs of the body are great to one designed for remodeling reversal when metabolic needs are less. (google.es)
  • 4 . The method of claim 1 further comprising delivering pacing pulses to a plurality of ventricular sites as defined by a specified pulse output configuration and in accordance with a defined pulse output sequence which begins after the AV pacing delay interval following an atrial sense or pace. (google.es)
  • Although connexin changes are important for the ventricular arrhythmic substrate in congestive heart failure (CHF), connexin alterations during CHF-related atrial arrhythmogenic remodeling have received limited attention. (ahajournals.org)
  • Left ventricular (LV) end-diastolic pressure and atrial refractory periods increased with CHF and normalized on CHF recovery. (ahajournals.org)
  • 2 The atria of dogs with ventricular tachypacing-induced CHF are characterized by structural remodeling, conduction abnormalities and the ability to sustain AF. (ahajournals.org)
  • We previously noted that the cessation of ventricular tachypacing, which is followed by the reversal of CHF, dissociates atrial size and function changes from structural remodeling and AF sustainability. (ahajournals.org)
  • Methods and Results: Freshly isolated left atrial fibroblasts were obtained from controls and dogs with CHF (ventricular tachypacing). (fujita-hu.ac.jp)
  • At later stages, the remodeling process proceeds to left ventricular dysfunction with the clinical consequence of the heart failure syndrome. (hindawi.com)
  • Atrial fibrillation (AF) often occurs in Brugada syndrome (BrS), and BrS patients with spontaneous AF often experience ventricular fibrillation (VF) attacks. (cdc.gov)
  • Left atrial volume index (LAVI) was measured by the modified Simpson method at left ventricular end-systole using echocardiography. (cdc.gov)
  • The role of the protease cathepsin A for the progression of left ventricular remote remodeling and atrial cardiomyopathy in ischemic cardiomyopathy is unknown. (onlinejacc.org)
  • In rats with ventricular ischemia and reperfusion, cathepsin A is up-regulated in the left ventricular and atrial tissue remote from the infarcted area. (onlinejacc.org)
  • Pharmacological inhibition of cathepsin A protease activity by SAR significantly reduces remote ventricular remodeling and atrial extracellular matrix remodeling, represented by fibrosis formation and connexin 43 lateralization. (onlinejacc.org)
  • Prevention of ventricular remote remodeling and atrial cardiomyopathy by SAR increased ventricular viable myocardium and atrial emptying function reducing susceptibility to atrial fibrillation. (onlinejacc.org)
  • Remote ventricular and atrial extracellular matrix remodeling may represent a promising target for pharmacological atrial fibrillation upstream therapy following myocardial infarction. (onlinejacc.org)
  • After myocardial infarction, remote ventricular remodeling and atrial cardiomyopathy progress despite successful revascularization. (onlinejacc.org)
  • In a rat model of ventricular ischemia/reperfusion, pharmacological inhibition of the protease activity of cathepsin A initiated at the time point of reperfusion prevented extracellular matrix remodeling in the atrium and the ventricle remote from the infarcted area. (onlinejacc.org)
  • This scenario was associated with preservation of more viable ventricular myocardium and the prevention of an arrhythmogenic and functional substrate for atrial fibrillation. (onlinejacc.org)
  • Remote ventricular extracellular matrix remodeling and atrial cardiomyopathy may represent a promising target for pharmacological atrial fibrillation upstream therapy following myocardial infarction. (onlinejacc.org)
  • Time course of right ventricular remodeling after percutaneous atrial septal defect closure: assessment of regional deformation properties with two-dimensional strain and strain rate imaging. (docphin.com)
  • Eroglu E, Cakal SD, Cakal B, Dundar C, Alici G, Ozkan B, Yazicioglu MV, Tigen K, Esen AM. Time course of right ventricular remodeling after percutaneous atrial septal defect closure: assessment of regional deformation properties with two-dimensional strain and strain rate imaging. (docphin.com)
  • Quantitative assessment of the right ventricular (RV) function in atrial septal defect (ASD) patients before and after closure remains difficult. (docphin.com)
  • Results: Preoperative left atrial dilation was associated with left ventricular hypertrophy and increased filling pressure. (elsevier.com)
  • Preoperative left atrial volume index was associated with persistent abnormalities in left ventricular filling pressure and left ventricular mass index at 1 year after surgery. (elsevier.com)
  • Aetna considers the Batista ventricular remodeling procedure, also known as partial left ventriculectomy, experimental and investigational because its effectiveness has not been established. (aetna.com)
  • The ventricular remodeling operation (also known as the Batista procedure, partial left ventriculectomy, heart reduction surgery, and wedge resection of the heart) has been proposed as a surgical procedure to replace or postpone heart transplantation in patients with dilated non-ischemic cardiomyopathy. (aetna.com)
  • Ventricular Remodeling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Ventricular Remodeling" by people in Harvard Catalyst Profiles by year, and whether "Ventricular Remodeling" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Ventricular Remodeling" by people in Profiles. (harvard.edu)
  • Insulin Resistance Modifies the Effects of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction (from the OMEGA-REMODEL Randomized Clinical Trial). (harvard.edu)
  • Coronary Microvascular Dysfunction, Left Ventricular Remodeling, and Clinical Outcomes in Patients With Chronic Kidney Impairment. (harvard.edu)
  • Furthermore, the morphologic repercussions of NVAF, including left atrium dilation and left ventricular systolic dysfunction, as well as the presence of left atrial appendage stasis indicators, could also help refine the risk stratification. (bioportfolio.com)
  • These compensatory mechanisms include neurohormonal activation, increased contractility, vasoconstriction, and ventricular hypertrophy and remodeling. (medscape.com)
  • Natriuretic peptides counteract vasoconstriction and are released upon atrial or ventricular stretch. (medscape.com)
  • Since the phenotypic expression of HCM is variable, and not uncommonly includes patients with mild and localised left ventricular hypertrophy, the differential diagnosis with physiological remodelling of athlete's heart not uncommonly arises. (bmj.com)
  • This substitution resulted in atrial myocytes that contract and relax more forcefully and quickly, resulting in atrial cardiomyocytes that behave as ventricular cardiomyocytes. (wikipedia.org)
  • Atrial fibrillation is the most common cardiac arrhythmia. (rug.nl)
  • Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling. (biomedsearch.com)
  • Associations of changes in LA volume (ΔLAV) with traditional risk factors, biomarkers, LV geometry, and remodeling by cardiac magnetic resonance imaging and detailed measurements of global and regional adiposity (by magnetic resonance imaging and dual-energy x ray absorptiometry) were assessed using multivariable linear regression. (ovid.com)
  • AHRE are felt to be a precursor to AF, and may be both the result and a cause of changs in the atrial electrophysiology, and structure (known as cardiac remodeling)that are associated with the development of AF. (clinicaltrials.gov)
  • The cardiac atria are chambers of active remodeling and dynamic collagen turnover during evolving heart failure. (springer.com)
  • Background Left atrial (LA) volume is an independent prognosticator in various cardiac diseases. (bmj.com)
  • Is lenient rate control associated with more adverse cardiac remodeling than strict rate control in patients with atrial fibrillation (AF)? (acc.org)
  • Lenient rate control does not promote adverse cardiac remodeling in patients with persistent AF. (acc.org)
  • PURPOSE: To prospectively determine the impact of sinus rhythm restoration on left-atrial (LA) volumes and function assessed by cardiac magnetic resonance (CMR) imaging within the first year after pulmonary vein isolation (PVI). (uzh.ch)
  • These data suggest that there is a direct, partly BP-independent effect of RDN on cardiac remodeling and occurrence of premature atrial contractions. (onlinejacc.org)
  • Cardiac pressure overload results in cardiac remodeling including myocardial hypertrophy, diastolic dysfunction, and left atrial (LA) enlargement. (onlinejacc.org)
  • Cathepsin-L contributes to cardiac repair and remodelling post-infarction. (semanticscholar.org)
  • Postoperative atrial fibrillation (AF) is the most common arrhythmia following cardiac surgery with extracorporeal circulation. (frontiersin.org)
  • Reactive oxygen species (ROS)-derived effects could result in lipid peroxidation, protein carbonylation, or DNA oxidation of cardiac tissue, thus leading to functional and structural myocardial remodeling. (frontiersin.org)
  • The interplay between cardiac matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of MMPs (TIMPs), is thought to be critical in atrial extracellular matrix (ECM) metabolism. (elsevier.com)
  • A system and method for managing and inhibiting cardiac remodeling in MI patients. (google.com)
  • 2. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 1 , wherein the pulse is excitatory. (google.com)
  • 4. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 1 , wherein a compromised area of cardiac tissue has stem cells deposited thereon. (google.com)
  • 5. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 4 , wherein the LV and RV electrodes are located so as to electrically stimulate the compromised area of cardiac tissue on which stem cells have been deposited. (google.com)
  • The uncertainty concerning the onset and the extent of cardiac remodeling in response to intensive training hinders medical evaluation by physician. (clinicaltrials.gov)
  • A better knowledge of the physiology of cardiac adaptation to training will enable physicians to correctly determine whether observed patterns of cardiac remodeling are physiological or pathological. (clinicaltrials.gov)
  • This prospective study proposes to assess in a trained-athlete population the cardiac remodeling in response to intensive exercise training. (clinicaltrials.gov)
  • Maladaptive remodeling of K + channels associated with cardiac and systemic diseases results in impaired repolarization and increased propensity for arrhythmias. (pubmedcentralcanada.ca)
  • Here, we review the diverse transcriptional, post-transcriptional, post-translational and epigenetic mechanisms contributing to regulating the expression, distribution and remodeling of cardiac K + channels under physiological and pathological conditions. (pubmedcentralcanada.ca)
  • Rationale: Fibroblasts are involved in cardiac arrhythmogenesis and contribute to the atrial fibrillation substrate in congestive heart failure (CHF) by generating tissue fibrosis. (fujita-hu.ac.jp)
  • Fibronectin containing the extra domain A (ED-A + Fn) was proven to serve as a valuable biomarker for cardiac remodeling. (hindawi.com)
  • This so-called myocardial remodeling initially enables compensatory mechanisms to maintain cardiac function despite the persisting pathologic stimuli. (hindawi.com)
  • Myocardial remodeling is a complex and heterogeneous process involving cardiac myocyte alterations, activation of fibroblasts, and transdifferentiation to myofibroblasts (MyoFb) as well as a dynamic functional and structural reorganization of the cardiac extracellular matrix (cECM) [ 2 , 4 - 6 ]. (hindawi.com)
  • The study aimed to investigate the intermediate-term effects of transcatheter atrial septal defect (ASD) closure on cardiac remodeling in children and adult patients. (erciyes.edu.tr)
  • In recent years, growing evidence suggests an association between obstructive sleep apnea (OSA), a common sleep breathing disorder which is increasing in prevalence as the obesity epidemic surges, and atrial fibrillation (AF), the most common cardiac arrhythmia. (hindawi.com)
  • Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that in humans is encoded by the NPPA gene. (wikipedia.org)
  • Following stimulation of atrial cells, proANP is released and rapidly converted to the 28-amino-acid C-terminal mature ANP on the cell surface by the cardiac transmembrane serine protease corin. (wikipedia.org)
  • Here we report an integrated omics approach, incorporating measurements of transcript abundance, protein abundance, and protein turnover to map the landscape of proteome remodeling in a mouse model of pathological cardiac hypertrophy. (nih.gov)
  • Circulating microRNAs may reflect or influence pathological cardiac remodeling and contribute to atrial fibrillation (AF). (bvsalud.org)
  • Left atrial size is a known risk factor providing prognostic information in several cardiac conditions. (elsevier.com)
  • Cine cardiac magnetic resonance (cine-CMR) provides excellent endocardial delineation, enabling accurate quantification of left atrial (LA) chamber size. (biomedcentral.com)
  • Each chapter deals with a different aspect of Atrial Fibrillation and was authored by internationally recognized experts in the evolving field of cardiac electrophysiology. (springer.com)
  • Because Atrial Fibrillation is so prevalent and affects all areas of medicine, the information in this book will be useful to cardiologists, cardiac surgeons, researchers, and all those in the medical field. (springer.com)
  • heart , atrial fibrillation (AF) and atrial flutter (Aflut), occur frequently after most types of cardiac surgeries. (bioportfolio.com)
  • This study will be a retrospective cohort analysis of all patients that underwent elective cardiac surgeries between 2000-2005 at Emory University Hospital, Crawford Long Hospital, or the Atlanta Veterans Affairs Medical Center to evaluate the relationship of pre-operative TZD use to the incidence of post-operative atrial arrhythmias. (bioportfolio.com)
  • Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting approximately 1% of the population. (kit.edu)
  • Atrial fibrillation (AF) is the most common cardiac arrhythmia and a source of significant morbidity and mortality [ 1 ]. (omicsonline.org)
  • Cardiac inflammatory disorders such as myocarditis, pericarditis, and cardiac surgery frequently are accompanied by atrial fibrillation [ 5 ]. (omicsonline.org)
  • The purpose of this study is to determine whether irbesartan will reduce the rate of recurrent atrial high rate episodes and the development of clinical sustained atrial fibrillation in patients with hypertension and permanent pacemaker. (clinicaltrials.gov)
  • OBJECTIVES To determine whether Gal-3 mediates sustained atrial fibrillation (AF)-induced atrial structural and electrical remodeling and contributes to AF perpetuation. (semanticscholar.org)
  • therefore neonatal rat atrial myocytes were subjected to cyclical stretch. (rug.nl)
  • Transverse t-tubules are a common feature in large mammalian atrial myocytes including human. (kompetenznetz-vorhofflimmern.de)
  • Objective: To determine the mechanisms underlying electrophysiological effects of palmitic (PA), stearic (SA) and oleic (OA) FFAs on sheep atrial myocytes. (umn.edu)
  • Methods: We used electrophysiological techniques, numerical simulations, biochemistry and optical imaging to examine the effects of acutely (≤ 15 min), short-term (4-6 hour) or 24-hour application of individual FFAs (10 μM) on isolated ovine left atrial myocytes (LAMs). (umn.edu)
  • Results: Acute and short-term incubation in FFAs resulted in no differences in passive or active properties of isolated left atrial myocytes (LAMs). (umn.edu)
  • Conclusions: SA disrupts t-tubular architecture and remodels properties of membrane ionic currents in sheep atrial myocytes, with potential implications in arrhythmogenesis. (umn.edu)
  • The influences of pioglitazone on AngII-induced L-type calcium channel (ICa-L) α1c expression and current density were evaluated in atrial myocytes (HL-1). (qxmd.com)
  • Pioglitazone improves potassium channel remodeling induced by angiotensin II in atrial myocytes. (qxmd.com)
  • The NPPA gene is expressed primarily in atrial myocytes and consists of 2 introns and three exons, with translation of this gene yielding a high molecular mass 151 amino acid polypeptide known as preproANP. (wikipedia.org)
  • The arrangement of atrial myocytes was disordered and the collagen volume fraction of the atrium tissue was elevated in the DM group compared with the control group , and improved by allopurinol . (bvsalud.org)
  • Dr Nattel's work has kindly demonstrated the central role of atrial fibrosis in the mechanistic method of this substrate for atrial fibrillation. (afsymposium.com)
  • Whether it is with ageing, heart failure, hypertension or mitral regurgitation, these result in atrial stretch, ionic remodeling and atrial fibrosis. (afsymposium.com)
  • Atrial fibrosis itself adds back to this, and results in persistent atrial fibrillation. (afsymposium.com)
  • There is clear evidence to suggest that AF feeds back on itself to remodel this process, and there is even a suggestion that it may induce further atrial fibrosis. (afsymposium.com)
  • He added: "We have now evaluated a number of conditions, both in the clinic and in the preclinical scenario, and it seems fairly uniform that the substrate that predisposes to atrial fibrillation is structural changes, be they interstitial fibrosis,low-voltage and scarring - the result is abnormal conduction. (afsymposium.com)
  • This study aimed to evaluate left atrial (LA) remodeling and fibrosis in paroxysmal atrial fibrillation (AF) using speckle tracking echocardiography (STE) based on the findings with radiofrequency catheter ablation (RFCA) so as to predict atrial remodeling prior to ablation. (springer.com)
  • (1) observed that the activation of angiotensin-converting enzyme (ACE)-dependent extracellular signal-regulated kinases (Erk1/Erk2) was involved in the mechanism of the development of atrial fibrosis in patients with AF. (onlinejacc.org)
  • It is well known that architectural alterations of the atria, including atrial dilation and tissue fibrosis, are associated with atrial dysfunction (5,6) . (onlinejacc.org)
  • (6) reported that electrical heterogeneity probably due to atrial fibrosis might play a critical role in the induction and promotion of AF in an arrhythmogenic substrate in the canine heart failure model. (onlinejacc.org)
  • Recent data show that interstitial fibrosis can predispose to atrial conduction impairment and AF induction. (elsevier.com)
  • We also describe the activation of bioactive molecules in both clinical studies and animal models to modulate MMPs and TIMPs and their effects on atrial fibrosis in AF. (elsevier.com)
  • Similar to observations seen in animals exposed to WNT-974, deletion of the collagen VI subunit, COL6A1 , has been shown to decrease aberrant remodeling and fibrosis in infarcted heart tissue. (nih.gov)
  • 11,12 Both structural (particularly tissue fibrosis) and connexin remodeling could contribute to CHF-associated AF. (ahajournals.org)
  • Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure. (qxmd.com)
  • Aims Left atrial (LA) fibrosis caused by various pathological stimuli is a common finding. (elsevier.com)
  • OBJECTIVE: Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling, contributing to the progressive nature of the arrhythmia. (biomedsearch.com)
  • Although a number of markers have been reported as potential predictors of paroxysmal atrial fibrillation progression towards persistent arrhythmia, their usefulness and clinical value need further validation. (scirp.org)
  • Pharmacological therapy for atrial fibrillation in the heart failure population remains limited due to sub-optimal drug efficacy and a likely increased mortality due to pro-arrhythmia. (scirp.org)
  • Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs electrical activation of the atria, rendering them increasingly permissive to the arrhythmia. (eur.nl)
  • Atrial fibrillation (AF) is the most common arrhythmia affecting patients after general thoracic surgery. (frontiersin.org)
  • Atrial fibrillation (AF) is a common arrhythmia which is associated with higher risk of stroke , heart failure and all-cause mortality . (bvsalud.org)
  • Here, we perform a gene-based analysis of GWAS data to test the hypothesis that PR interval candidate genes also associate with left atrial remodeling and arrhythmia recurrence following AF catheter ablation. (cdc.gov)
  • Atrial fibrillation is the most common arrhythmia in patients visiting a primary care practice. (aafp.org)
  • Persistent atrial fibrillation is defined by persistence of the arrhythmia until cardioversion is performed. (aafp.org)
  • Atrial fibrillation is a complex arrhythmia and its precise mechanisms remain unclear. (fda.gov)
  • Atrial fibrillation (AF) is a highly prevalent condition associated with pronounced morbidity, mortality, and socioeconomic burden, accounting for more hospitalization days than any other arrhythmias. (ahajournals.org)
  • Patients with permanent pacemakers have a high risk of atrial fibrillation (AF), particularly those with hypertension, sinus node dysfunction, and those with short episodes of atrial arrhythmias, known as atrial high-rate episodes (AHRE). (clinicaltrials.gov)
  • It may be prudent to abort both types of arrhythmias early to prevent electrical remodeling. (onlinejacc.org)
  • Five of six patients experienced resolution of their preclosure arrhythmias, whereas the remaining patient continued to have paroxysmal atrial fibrillation. (erciyes.edu.tr)
  • Cine-CMR quantified LA diameter provides a simple measure of atrial remodeling that correlates well with LA area, yielding similar predictive value for stratifying MR as well as longitudinal risk for atrial arrhythmias. (biomedcentral.com)
  • Post-operative atrial arrhythmias seem to be related to the degree of inflammation and oxidative stress induced during surgery. (bioportfolio.com)
  • 2-4) Our group and others have shown that atrial arrhythmias are associated with increased oxidative stress. (bioportfolio.com)
  • Dr Fabritz's main interests are in molecular and translational cardiology, mechanisms of heart disease, cardiomyopathies and arrhythmias, sudden death, and atrial fibrillation. (nature.com)
  • This study sought to determine whether chronic atrial fibrillation (AF) and atrial flutter in patients lead to electrical remodeling of the human atrial myocardium, manifested by an abnormal relation between atrial cycle length and action potential duration (APD). (onlinejacc.org)
  • Transcatheter ASD closure can reverse electrical and mechanical changes in atrial myocardium, resulting in a subsequent reduction in P maximum and P dispersion times. (erciyes.edu.tr)
  • Thus, if the refractory period of the atrial myocardium is short (i.e., faster recovery) or if the conduction time is so slow that the tissue can recover before the wavelet arrives, atrial fibrillation can develop. (aafp.org)
  • These findings are consistent with recent observations that AF per se may cause ECM remodeling, and have potentially important consequences for understanding and preventing the mechanisms underlying AF progression. (biomedsearch.com)
  • Marking the very first presentation of the 2015 AF Symposium, Prashanthan Sanders from the Royal Adelaide Hospital, Australia, kickstarted proceedings on Thursday morning with an exploration of the mechanisms of atrial remodeling and their impact of AF outcomes. (afsymposium.com)
  • Considering previous observations, we hypothesized that structural abnormalities caused by an activated renin-angiotensin system during chronic atrial activation might participate in the mechanisms of AF maintenance. (onlinejacc.org)
  • Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. (semanticscholar.org)
  • Background: Atrial electrical remodeling (AER) is one of the mechanisms by which atrial fibrillation (AF) begets AF. (elsevier.com)
  • Lin, CS & Pan, CH 2008, ' Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation ', Cellular and Molecular Life Sciences , vol. 65, no. 10, pp. 1489-1508. (elsevier.com)
  • Here, the factors contributing to the diverse properties and functional roles of myocardial K + channels are reviewed, and the molecular mechanisms contributing to the physiological regulation and pathological remodeling of myocardial K + channels are discussed. (pubmedcentralcanada.ca)
  • The present review outlines the molecular and biochemical mechanisms which play a role in muscular atrophy, hypertrophy, and remodeling. (degruyter.com)
  • Congestive heart failure (CHF) predisposes to atrial fibrillation (AF), although the underlying mechanisms remain incompletely understood. (ahajournals.org)
  • However, the underlying regulatory mechanisms of atrial remodeling remain unclear. (elsevier.com)
  • Complicated mechanisms are involved in atrial remodeling , of which CaMKII may be a key node signal. (bvsalud.org)
  • Methods and Results -In 24 dogs, the atrial effective refractory period (AERP) was measured before, during, and after rapid atrial pacing. (ahajournals.org)
  • Rapid atrial pacing at 800 bpm was maintained for 180 minutes. (ahajournals.org)
  • Conclusions -The inhibition of endogenous Ang II prevented AERP shortening during rapid atrial pacing. (ahajournals.org)
  • Recent studies in animal models and humans have shown that atrial fibrillation induced by rapid atrial pacing itself produces shortening of the atrial effective refractory period (AERP) and reverses the normal physiological rate adaptation of refractoriness. (ahajournals.org)
  • This study investigated the hypothesis that rapid atrial cardiomyocyte activation produces factors that influence atrial fibroblast proliferation and secretory functions. (biomedsearch.com)
  • We previously reported that the blockade of angiotensin II (Ang II) prevented the electrical remodeling induced by short-term rapid atrial pacing (4) . (onlinejacc.org)
  • The AF duration, atrial effective refractory period (AERP) at four sites in the RA, and intra-atrial conduction time (CT) from the RA appendage to the other three sites were measured every week. (onlinejacc.org)
  • CHF causes atrial connexin changes, but these are not essential for CHF-related conduction disturbances and AF promotion, which are rather related primarily to fibrotic interruption of muscle bundle continuity. (ahajournals.org)
  • We therefore exploited CHF reversal to assess the reversibility of atrial connexin alterations and evaluate their contribution to CHF-related conduction disturbances and AF maintenance. (ahajournals.org)
  • Intra-atrial conduction time (CT) was defined as the interval from the stimulus at the high right atrium to atrial deflection at the distal portion of the coronary sinus. (cdc.gov)
  • The surface ECG lead II, intracardiac electrograms, right atrial pressure, and blood pressure were continuously monitored and recorded at a paper speed of 100 mm/s (San Ei 8 MI4). (ahajournals.org)
  • A pacing lead introduced into the femoral vein was placed in the right atrial appendage to measure the AERP. (ahajournals.org)
  • To minimize confounding effects caused by electrode polarization, all refractory period measurements were made with the pacing lead, which was not used for high-frequency pacing and was positively affixed to the right atrial appendage. (ahajournals.org)
  • Methods and Results- The miRNA transcriptome was analyzed by microarray and verified by real-time reverse-transcription polymerase chain reaction with left atrial samples from dogs with AF established by right atrial tachypacing for 8 weeks and from human atrial samples from AF patients with rheumatic heart disease. (ahajournals.org)
  • Using monophasic action potential recordings at two right atrial sites simultaneously, we determined in 7 patients with chronic AF and 13 with chronic atrial flutter (3 weeks to 3 years in duration) the relation between paced cycle length and APD at 90% repolarization (APD90) 15 to 30 min after conversion to sinus rhythm. (onlinejacc.org)
  • AF and atrial flutter lead to marked, quantitatively similar decreases in the right atrial APD during steady state pacing and extrastimulation a considerable time after cardioversion. (onlinejacc.org)
  • Table 1 shows correlations between high scar score and right atrial enlargement, but no other analyzed variables. (biomedcentral.com)
  • There were no significant differences between patients with cardioversion from atrial flutter and those with cardioversion from AF. (onlinejacc.org)
  • APD90 at a steady state cycle length of 600 ms showed no significant correlation with the duration of previous AF or atrial flutter. (onlinejacc.org)
  • These data confirm that both AF and atrial flutter lead to electrical remodeling in the human atrium, with a preponderance at longer cycle lengths. (onlinejacc.org)
  • Clinical follow-up was performed via medical record review, with atrial fibrillation (AF) or flutter (AFl) verified based on physician documentation. (biomedcentral.com)
  • however, little is known about how they affect atrial pathophysiology or electrophysiology. (ahajournals.org)
  • It is important to determine which Ang II formation pathway (ACE or chymase) is more closely related to atrial electrophysiology. (ahajournals.org)
  • 1 - 5 A characteristic of both clinical and experimental AF is the alteration of electrophysiology that promotes persistent AF even in the absence of progressive underlying heart disease, so-called atrial remodeling or "AF begets AF. (ahajournals.org)
  • HealthDay News - Preprocedural serum atrial natriuretic peptide (ANP) levels predict left atrial reverse remodeling after catheter ablation in patients with atrial fibrillation (AF), according to a study published online March 23 in JACC: Clinical Electrophysiology . (empr.com)
  • The aim of this work is to integrate the effects of dronedarone into a model of atrial electrophysiology. (kit.edu)
  • These results indicate for the first time that Ang II may be involved in the mechanism of atrial electrical remodeling and that the blockade of Ang II may lead to the better therapeutic management of human atrial fibrillation. (ahajournals.org)
  • We know that AF is a progressive disease that most patients go from paroxysmal to persistent, and then to permanent atrial fibrillation," he began. (afsymposium.com)
  • If an individual has a few risk factors, the incidence of persistent atrial fibrillation is much lower than if you have a greater number of risk factors, in which case it is more likely that these individuals will progress to persistent atrial fibrillation. (afsymposium.com)
  • Effects of persistent atrial fibrillation on serum galectin-3 levels. (semanticscholar.org)
  • Plasma galectin-3 predicts clinical outcomes after catheter ablation in persistent atrial fibrillation patients without structural heart disease. (semanticscholar.org)
  • Experimental studies in goats and isolated human atrial tissue have shown that prolonged AF leads to persistent shortening of atrial refractoriness, a phenomenon referred to as electrical remodeling and which helps to explain why AF begets AF. (onlinejacc.org)
  • Thus, cardioversion is used only in cases of acute and chronic persistent atrial fibrillation and not in cases previously demonstrated to be refractory. (aafp.org)
  • We investigated the concentrations of IL-33, its soluble ST2 receptors, and high-sensitivity C-reactive protein levels (hsCRP) in the sera of 92 patients with persistent atrial fibrillation, and 68 controls. (omicsonline.org)
  • However, the pathophysiological role of tissue Ang II in atrial electrical remodeling has not been investigated. (ahajournals.org)
  • Methods and Results: Primary ECs were isolated from porcine atrial tissue. (mdpi.com)
  • Enhanced expression levels of vascular cell adhesion molecule (VCAM)-1, tissue factor, transforming growth factor (TGF)-β and MMP-2 and 9 characterized the senescence-associated secretory phenotype of atrial ECs. (mdpi.com)
  • Conclusions: Thrombin promotes premature ageing and senescence of atrial ECs and may pave the way to deleterious remodeling of atrial tissue by a local up-regulation of the angiotensin system and by promoting pro-inflammatory, pro-thrombotic, pro-fibrotic and pro-remodeling responses. (mdpi.com)
  • We demonstrate that WNT-974 can improve the recovery of heart function after left anterior descending coronary artery ligation by mitigating adverse remodeling of infarcted tissue. (nih.gov)
  • The effects of pioglitazone on AngII-induced connective tissue growth factor (CTGF) expression and cell proliferation were assessed in primary-cultured mouse atrial fibroblasts. (qxmd.com)
  • Later, the substance was purified from heart tissue by several groups and named atrial natriuretic factor (ANF) or ANP. (wikipedia.org)
  • maintaining the tissue growth member in the left atrial appendage with a locking element, the locking element including multiple fingers that collapse directly dependent upon proximally moving the threaded pusher member relative to the tissue growth member. (google.es)
  • 7. The method according to claim 6 , wherein pushing the tissue growth member over the tether further comprises positioning the catheter within the left atrial appendage and deploying the tissue growth member from the catheter while slidably coupled with the tether. (google.es)
  • In the course of chronic AF (cAF), electrical remodeling modifies the properties of the affected atrial tissue. (kit.edu)
  • Finally, a comparison of both agents and their impact on healthy and electrically remodeled tissue shall be carried out. (kit.edu)
  • The electrophysiologic mechanism for atrial fibrillation appears to be multiple wavelets of reentry. (aafp.org)
  • There is increasing evidence that inflammation is a relevant player in structural atrial remodeling that represents the main mechanism for atrial fibrillation (AF) persistence. (omicsonline.org)
  • Until the results of several large-scale randomized clinical trials are available, the decision to choose cardioversion or maintenance of sinus rhythm must be individualized, based on relief of symptoms and reduction of the morbidity and mortality associated with atrial fibrillation. (aafp.org)
  • Hypoxic stress upsets the balance in the normal relationships between mitogenic and growth inhibiting pathways in lung, resulting in pulmonary vascular remodeling characterized by hyperplasia of pulmonary arterial smooth muscle cells (PASMCs) and fibroblasts and enhanced deposition of extracellular matrix. (ovid.com)
  • BACKGROUND Galectin-3 (Gal-3) mediates extracellular matrix remodeling in heart failure, but its role in AF progression remains unexplored. (semanticscholar.org)
  • Impact of biomarkers of inflammation and extracellular matrix turnover on the outcome of atrial fibrillation ablation: importance of matrix metalloproteinase-2 as a predictor of atrial fibrillation recurrence. (semanticscholar.org)
  • However, LV remodeling due to structural and functional changes in the extracellular matrix (ECM) often progresses even following successful revascularization and is the most common reason for heart failure after myocardial infarction (3,4) . (onlinejacc.org)
  • Aortic stenosis results in increased filling pressures with progressive left atrial enlargement and dysfunction. (bmj.com)
  • Atrial biopsies from AF patients display mitochondrial dysfunction, evidenced by aberrant ATP levels, upregulation of a mitochondrial stress chaperone and fragmentation of the mitochondrial network. (eur.nl)
  • The pathophysiological role of mitochondrial dysfunction is substantiated by the attenuation of AF remodeling by preventing an increased mitochondrial Ca2+-influx through partial blocking or downregulation of the mitochondrial calcium uniporter, and by SS31, a compound that improves bioenergetics in mitochondria. (eur.nl)
  • Atrial fibrillation inducibility and duration were higher and longer only in the LVH group (P = 0.002, 0.079, respectively), and isolated LV diastolic dysfunction and elevated LV pressure were observed. (elsevier.com)
  • Morris DA, Parwani A, Huemer M, Wutzler A, Bekfani T, Attanasio P, Friedrich K, Kuhnle Y, Haverkamp W, Boldt LH (2013) Clinical significance of the assessment of the systolic and diastolic myocardial function of the left atrium in patients with paroxysmal atrial fibrillation and low CHADS(2) index treated with catheter ablation therapy. (springer.com)
  • age: 57±10years) with paroxysmal or non-paroxysmal atrial fibrillation were studied serially using CMR at baseline and at 1-, 3-, 6- and 12-month intervals following PVI. (uzh.ch)
  • Paroxysmal atrial fibrillation is defined as recurrent episodes of spontaneously terminating atrial fibrillation. (aafp.org)
  • First, different aspects of structural atrial remodeling are reviewed with a special focus on stretch and its contribution to structural remodeling. (rug.nl)
  • Nademanee K, Lockwood E, Oketani N, Gidney B (2010) Catheter ablation of atrial fibrillation guided by complex fractionated atrial electrogram mapping of atrial fibrillation substrate. (springer.com)
  • Mirza M, Caracciolo G, Khan U, Mori N, Saha SK, Srivathsan K, Altemose G, Scott L, Sengupta P, Jahangir A (2011) Left atrial reservoir function predicts atrial fibrillation recurrence after catheter ablation: a two-dimensional speckle strain study. (springer.com)
  • While understanding left atrial wall thickness around PVs (PVWT) prior to catheter ablation is important, its clinical implications are not known. (yonsei.ac.kr)
  • We assessed the effects of catheter ablation of PVCs on parameters of LV diastolic function and LA remodeling. (elsevier.com)
  • Conclusion: Catheter ablation of PVCs improved LV diastolic function and resulted in left atrial reverse remodeling. (elsevier.com)
  • PR Interval Associated Genes, Atrial Remodeling and Rhythm Outcome of Catheter Ablation of Atrial Fibrillation-A Gene-Based Analysis of GWAS Data. (cdc.gov)
  • PR interval prolongation has recently been shown to associate with advanced left atrial remodeling and atrial fibrillation (AF) recurrence after catheter ablation. (cdc.gov)
  • While different genome-wide association studies (GWAS) have implicated 13 loci to associate with the PR interval as an AF endophenotype their subsequent associations with AF remodeling and response to catheter ablation are unknown. (cdc.gov)
  • Of those, ITGA9 and SOX5 were significantly associated with left atrial low voltage areas and left atrial diameter and subsequently with AF recurrence after radiofrequency catheter ablation. (cdc.gov)
  • This study suggests contributions of ITGA9 and SOX5 to AF remodeling expressed as PR interval prolongation, low voltage areas and left atrial dilatation and subsequently to response to catheter ablation. (cdc.gov)
  • Hoit BD, Shao Y, Gabel M. Left atrial systolic and diastolic function accompanying chronic rapid pacing-induced atrial failure. (springer.com)
  • patients with subsequent relapse of atrial fibrillation, however, exhibited no significant change of LA diastolic and systolic volumes or LA ejection fraction. (uzh.ch)
  • CONCLUSION: Restoration of sinus rhythm led to a significant and progressive decrease of left-atrial diastolic and systolic volumes during one year following pulmonary vein isolation. (uzh.ch)
  • Background: Epicardial adiposity and plasma levels of free fatty acids (FFAs) are elevated in atrial fibrillation, heart failure and obesity, with potentially detrimental effects on myocardial function. (umn.edu)
  • At the molecular level, angiotensin II, transforming growth factor-β1, inflammation and oxidative stress are particularly important for ECM dysregulation and atrial fibrotic remodeling in AF. (elsevier.com)
  • These data indicate xanthine oxidase inhibition can reduce oxidative stress and ameliorate atrial electrical remodeling . (bvsalud.org)
  • Our group and others have shown that atrial abnormal heart beats are associated with increased oxidative stress. (bioportfolio.com)
  • In addition, the effects of thrombin on atrial fibroblasts and remodeling are studied. (rug.nl)
  • METHODS: Cultured canine atrial fibroblasts were treated with medium from rapidly-paced atrial cardiomyocytes, non-paced cardiomyocytes and cardiomyocyte-pacing medium only, and analyzed by [(3)H]thymidine incorporation, Western blot and real-time RT-PCR. (biomedsearch.com)
  • Pioglitazone attenuated AngII-induced CTGF expression and proliferation in atrial fibroblasts, and pioglitazone also inhibited the expression or phosphorylation of AngII-induced transforming growth factor-β1 (TGF-β1), tumor necrosis factor receptor associated factor 6 (TRAF6), TGF-β-associated kinase 1 (TAK1) and Smad2/3. (qxmd.com)
  • Besides, pioglitazone inhibited AngII-induced production of AngII type I receptor (AT1R) and downregulation of PPAR-γ in both atrial fibroblasts and HL-1 cells. (qxmd.com)
  • In conclusion, Pioglitazone suppresses AngII-induced CTGF expression and proliferation in atrial fibroblasts, which might be at least in part related with its inhibitory effects on TGF-β1/Smad2/3 and TGF-β1/TRAF6/TAK1 signaling pathways. (qxmd.com)
  • Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts. (qxmd.com)
  • Pioglitazone inhibits angiotensin II-induced atrial fibroblasts proliferation via NF-κB/TGF-β1/TRIF/TRAF6 pathway. (qxmd.com)
  • After excluding significant mitral regurgitation, LA enlargement was also associated with increased V-wave amplitude, indicative of decreased atrial compliance. (springer.com)
  • Multivariate analysis showed that LA volume increase at 10 years after PMV was independently related to the post-PMV mitral valve area, the echo score, the presence of atrial fibrillation and post-PMV LA volume. (bmj.com)
  • Left atrial enlargement associated with mitral regurgitation (MR) predicts a poor prognosis. (elsevier.com)
  • Using samples obtained during valve replacement surgery in patients with mitral valve prolapse (MVP), we set out to define inter-chamber differences, the intersect of proteomic data with genetic or genomic datasets, and the impact of left atrial dilation on the proteome of patients with no history of atrial fibrillation (AF). (regionh.dk)
  • In a porcine model of left atrial remodeling following mitral regurgitation, VLC-2 was shown to be upregulated. (wikipedia.org)
  • In this study, 47% of the patients exhibited left atrial reverse remodeling after RFCA for AF, with a concomitant improvement in serum ANP, BNP, and hs-CRP levels," the authors write. (empr.com)
  • Atrial natriuretic peptide (ANP) reduces pulmonary vascular resistance and attenuates hypoxia-induced pulmonary hypertension in vivo and PASMC proliferation and collagen synthesis in vitro. (ovid.com)
  • Previous studies in a hypertensive animal model of stroke and in humans showed that mutations of the atrial natriuretic peptide (ANP) gene are associated with increased risk of stroke. (mdc-berlin.de)
  • The discovery of a natriuretic factor (one that promotes kidney excretion of salt and water) was first reported by de Bold in 1981 when rat atrial extracts were found to contain a substance that increased salt and urine output in the kidney. (wikipedia.org)
  • ANP is one of a family of nine structurally similar natriuretic hormones: seven are atrial in origin. (wikipedia.org)
  • ANP is secreted in response to: Stretching of the atrial wall, via Atrial volume receptors Increased Sympathetic stimulation of β-adrenoceptors Increased sodium concentration (hypernatremia), though sodium concentration is not the direct stimulus for increased ANP secretion Endothelin, a potent vasoconstrictor Three types of atrial natriuretic peptide receptors have been identified on which natriuretic peptides act. (wikipedia.org)
  • Conclusions- miR-328 contributes to the adverse atrial electric remodeling in AF through targeting L-type Ca 2+ channel genes. (ahajournals.org)
  • Conclusions- Left atrial dilatation in the population is more common in black and Hispanic than in white individuals and is associated with parallel changes in the LV. (ovid.com)
  • Conclusions Candesartan can prevent the promotion of AF by suppressing the development of structural remodeling. (onlinejacc.org)
  • Conclusions: CHF upregulates fibroblast KCNJ2 expression and currents, thereby hyperpolarizing RMP, increasing Ca 2+ entry, and enhancing atrial fibroblast proliferation. (fujita-hu.ac.jp)
  • Conclusions: Larger LAA volume predicts recurrence after ablation of AF in patients with enlarged LA. These finding suggests that LAA is an important substrate of AF in remodeled LA. (elsevier.com)
  • Conclusions: In patients with symptomatic severe aortic valve stenosis undergoing aortic valve replacement, left atrial volume provides important prognostic information beyond standard risk factors. (elsevier.com)
  • Methods Before and 6 months after RDN, BP, HR, LV mass, left atrial volume index (LAVI), diastolic function (echocardiography), and premature atrial contractions (PAC) (Holter electrocardiogram) were assessed in 66 patients with resistant hypertension. (onlinejacc.org)
  • however, the effect on diastolic function and left atrial (LA) remodeling is unclear. (elsevier.com)
  • Background- A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated with profound reduction of L-type Ca 2+ current and shortening of the action potential duration. (ahajournals.org)
  • Dobrev D. Prevention of atrial fibrillation complications with antiarrhythmic drugs: a still unmet need in the clinical practice. (kompetenznetz-vorhofflimmern.de)
  • Here, we examined mitochondrial function in experimental model systems for AF (tachypaced HL-1 atrial cardiomyocytes and Drosophila melanogaster) and validated findings in clinical AF. (eur.nl)
  • Hypothesis: Different alterations of volume between left atrium (LA) and appendage (LAA) can predict clinical outcome of ablation of atrial fibrillation (AF). (elsevier.com)
  • The authors concluded that PLV could provide structural remodeling of the heart that might result in temporary improvement in clinical compensation. (aetna.com)
  • This guidance provides FDA's recommendations on clinical trial designs for surgical ablation devices intended for the treatment of atrial fibrillation (AF). (fda.gov)
  • Atrial Remodeling in Pregnant Hypertensive Women: Comparison between Chronic and Gestational Hypertension. (biomedsearch.com)
  • CONCLUSION: Patients with chronic hypertension showed a more marked increased of LA volumes compared to gestational hypertension due to a remodeling of atrial shape as effect of chronic overload. (biomedsearch.com)
  • Objectives The purpose of the present study was to evaluate the effect of angiotensin II type 1 receptor (AT1R) antagonist on chronic structural remodeling in atrial fibrillation (AF). (onlinejacc.org)
  • However, the effect of candesartan on chronic structural remodeling in AF is unclear. (onlinejacc.org)
  • Atrial fibrillation may be divided into acute and chronic forms. (aafp.org)
  • The chronic hemodynamic stresses on the heart lead to remodeling. (medscape.com)
  • Electrical, contractile and structural remodeling have been characterized in atrial fibrillation (AF), and the latter is considered to be the major contributor to AF persistence. (elsevier.com)
  • Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. (springer.com)
  • Hence, targeting thrombin and/or angiotensin systems may efficiently prevent atrial endothelial senescence. (mdpi.com)
  • Several studies have shown that activation of the renin-angiotensin system is associated with the mechanism of atrial fibrillation (AF) (1-3) . (onlinejacc.org)
  • They also showed the down-regulation of atrial angiotensin II type 1 receptor (AT1R) and the up-regulation of AT2R in AF patients (2) . (onlinejacc.org)
  • RAAS hyperactivity may be attenuated pharmacologically with angiotensin II receptor blockers (ARB) which in systemic hypertension with LV hypertrophy has been associated with reverse remodelling. (clinicaltrials.gov)
  • The hypothesis is that in patients undergoing AVR for symptomatic AVS, 12 months post operative blockade of the angiotensin II receptor will accelerate LV and LA reverse remodelling, reduce filling pressures and suppress neurohormonal activation compared with conventional therapy. (clinicaltrials.gov)
  • It has been demonstrated that atrial remodeling contributes toward atrial fibrillation (AF) maintenance and angiotensin II (AngII) is involved in the pathogenesis of atrial remodeling. (qxmd.com)
  • Atrial remodeling refers to changes in the atria, including structural changes such as an increase in atrial size. (rug.nl)
  • Therefore, in the present study, we examined the inhibitory effects of an AT 1 receptor antagonist, candesartan, or an ACEI, captopril, on the atrial electrical remodeling induced by rapid pacing in a dog model. (ahajournals.org)
  • Moreover, in a porcine model of atrial fibrillation, VLC-2 mRNA expression showed the greatest change, being upregulated 9.4-fold and 7.3-fold in left and right atria, respectively. (wikipedia.org)
  • In a canine model of atrial fibrillation, decreased atrial contractility was associated with decreased ALC-2 and myosin binding protein C phosphorylation. (wikipedia.org)
  • Atrial fibrillation ablation, since it allows for therapy without the need for toxic medication, has the potential to become mainstream treatment in patients with drug refractory, symptomatic atrial fibrillation and heart failure. (scirp.org)
  • The use of ablation in the treatment of atrial fibrillation has captured the greatest attention in journals and at national meetings, and it is a major focus of this book. (springer.com)
  • Advancements in the treatment and prevention of Atrial Fibrillation are presented in this important new book. (springer.com)
  • Dabigatran (Pradaxa) is an orally administered direct thrombin inhibitor labeled for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. (aafp.org)
  • Dabigatran is superior to warfarin for stroke prevention in patients with atrial fibrillation, with similar rates of major bleeding. (aafp.org)
  • Home / Test Division / Reference Database / 2000 to 2009 / 2008 / Matrix metalloproteinase inhibition attenuates atrial remodeling and vulnerability to. (umn.edu)
  • Alpha(1)-adrenergic stimulation by phenylephrine in atrial muscle strips showed an 80% increase in ALC-2 phosphorylation coordinate with enhanced contractile force, which was inhibited by both Rho kinase and myosin light chain kinase inhibition. (wikipedia.org)
  • 3 Atrial fibrillation also can decrease exercise tolerance and has been associated with tachycardia-induced cardiomyopathy. (aafp.org)
  • Processes that increase atrial size, such as valvular heart disease, ischemic heart disease and dilated cardiomyopathy, provide a greater surface area for the development of multiple reentrant wavelets. (aafp.org)
  • Atrial Fibrillation-Mediated Cardiomyopathy. (harvard.edu)
  • However, the difference of atrial remodelling via haemodynamic change in diverse cardiomyopathy has not been elucidated. (elsevier.com)
  • in dilated cardiomyopathy, this change was concomitant with enhanced sensitivity of atrial fibers to calcium. (wikipedia.org)