Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Compounds with a BENZENE fused to IMIDAZOLES.
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.
An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR.
Abnormally rapid heartbeats originating from one or more automatic foci (nonsinus pacemakers) in the HEART ATRIUM but away from the SINOATRIAL NODE. Unlike the reentry mechanism, automatic tachycardia speeds up and slows down gradually. The episode is characterized by a HEART RATE between 135 to less than 200 beats per minute and lasting 30 seconds or longer.
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.
A generic expression for any tachycardia that originates above the BUNDLE OF HIS.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.
A series of actions, sometimes symbolic actions which may be associated with a behavior pattern, and are often indispensable to its performance.
The chambers of the heart, to which the BLOOD returns from the circulation.
Reflex contraction of a muscle in response to stretching, which stimulates muscle proprioceptors.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The act or practice of killing for reasons of mercy, i.e., in order to release a person or animal from incurable disease, intolerable suffering, or undignified death. (from Beauchamp and Walters, Contemporary Issues in Bioethics, 5th ed)
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.
A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).
Irregular HEART RATE caused by abnormal function of the SINOATRIAL NODE. It is characterized by a greater than 10% change between the maximum and the minimum sinus cycle length or 120 milliseconds.
The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).
Diseases that do not exhibit symptoms.
The veins that return the oxygenated blood from the lungs to the left atrium of the heart.
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic biomedical research that is not targeted to specific diseases and funds studies on genes, proteins, and cells, as well as on fundamental processes like communication within and between cells and metabolism. It was established in 1962.
Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The gaseous envelope surrounding a planet or similar body. (From Random House Unabridged Dictionary, 2d ed)
Long-term maintenance hemodialysis in the home.
Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Portable peritoneal dialysis using the continuous (24 hours a day, 7 days a week) presence of peritoneal dialysis solution in the peritoneal cavity except for periods of drainage and instillation of fresh solution.
Facilities which provide nursing supervision and limited medical care to persons who do not require hospitalization.
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.

Pre-procedural prediction of termination of persistent atrial fibrillation by catheter ablation as an indicator of reverse remodeling of the left atrium. (1/11)

BACKGROUND: The pre-procedural prediction of atrial fibrillation (AF) termination by catheter ablation in patients with persistent AF has not been evaluated fully. The aim of this study was to evaluate the pre-procedural predictors of persistent AF termination by ablation associated with the possibility of reverse remodeling of the left atrium (LA). METHODS AND RESULTS: Seventy consecutive patients (mean age, 62+/-8 years) with persistent or long-standing persistent AF underwent ablation. They were divided into 2 groups: those with AF terminated by ablation (n=14; group 1) and those with AF terminated by cardioversion after ablation (n=56; group 2). The left atrial appendage (LAA) contraction velocity determined on transesophageal echocardiography was significantly decreased in group 2 as compared to group 1 (P<0.001). Kaplan-Meier analysis showed that the group 1 patients had a higher AF-free survival rate than those in group 2 during 12+/-4.1 months of follow-up (P=0.048). The LA reverse remodeling ratio, given as the volume difference between before and 3 months after ablation in group 1, was significantly greater after ablation than that in group 2 (25.8+/-13% vs. 15.0+/-15%, P=0.015). Multivariate logistic regression analysis indicated that the LAA contraction velocity was an independent predictor of persistent AF termination by ablation (P=0.018). CONCLUSIONS: The LAA contraction velocity was the only non-invasive pre-procedural predictor of persistent AF termination by ablation, indicating the possibility of reverse remodeling of the LA.  (+info)

Changes in microRNAs expression are involved in age-related atrial structural remodeling and atrial fibrillation. (2/11)

BACKGROUND: Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been implicated in the aging process and in the regulation of extracellular matrix proteins. However, their role in age-related cardiac remodeling and atrial fibrillation (AF) was not well understood. The present study was designed to decipher molecular mechanisms underlying age-related atrial structural remodeling and AF. METHODS: Three groups of dogs were studied: adult and aged dogs in sinus rhythm and with persistent AF induced by rapid atrial pacing. The expressions of microRNAs were measured by quantitative real-time polymerase chain reaction. Pathohistological and ultrastructural changes were tested by light and electron microscopy. Apoptosis index of myocytes was detected by TUNEL. RESULTS: Samples of atrial tissue showed the abnormal pathohistological and ultrastructural changes, the accelerated fibrosis, and apoptosis with aging and/or in AF dogs. Compared to the adult group, the expressions of microRNAs-21 and -29 were significantly increased, whereas the expressions of microRNAs-1 and -133 showed obvious downregulation tendency in the aged group. Compared to the aged group, the expressions of microRNAs-1, -21, and -29 was significantly increased in the old group in AF; contrastingly, the expressions of microRNA-133 showed obvious downregulation tendency. CONCLUSION: These multiple aberrantly expressed microRNAs may be responsible for modulating the transition from adaptation to pathological atrial remodeling with aging and/or in AF.  (+info)

An Angiotensin receptor blocker prevents arrhythmogenic left atrial remodeling in a rat post myocardial infarction induced heart failure model. (3/11)

 (+info)

Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing. (4/11)

 (+info)

MicroRNAs in pulmonary arterial remodeling. (5/11)

 (+info)

Left atrial endocardial fibrosis and intra-atrial thrombosis - landmarks of left atrial remodeling in rats with spontaneous atrial tachyarrhythmias. (6/11)

INTRODUCTION: Histological abnormalities are common findings in the left atria (LA) of atrial fibrillation (AF) patients. We aimed to assess LA histological abnormalities in our model of spontaneous atrial tachyarrhythmias in rats. MATERIALS AND METHODS: LA sampling was performed in 12 spontaneously hypertensive rats (SHRs) and eight age-matched Wistar-Kyoto (WKY) rats. Tissue sections were stained with Masson's trichrome and Hematoxylin-Eosin-Safran and examined with a light microscope. A 0 to 3 scoring system was used to quantify the severity of LA structural abnormalities. LA von Willebrand factor (vWF) content was also assessed using immunohistochemical staining. RESULTS: In six of the eight SHRs, LA fibrosis, inflammatory infiltrates, and myocyte necrosis of varying grades of severity were observed. The most frequent feature was endocardial fibrosis, which was observed in six SHRs and in none of the WKY rats. Intra-atrial thrombosis was found in three SHRs and in none of the WKY rats. The intensity of vWF-related fluorescence was higher in the atrial endocardium of SHRs compared to age-matched WKY rats. CONCLUSIONS: Our findings reinforce the role of LA structural abnormalities in atrial arrhythmogenicity. However, two SHRs did not present LA histological abnormalities despite the presence of arrhythmias. This finding suggests that the LA remodeling-atrial tachyarrhythmia relationship could be highly nonlinear and that atrial fibrosis is more likely to be a facilitator of atrial arrhythmogenicity, rather than a prerequisite. We also provide evidence that intra-atrial thrombosis accompanies LA structural remodeling in arrhythmic rats. Increased endocardial platelet adhesion molecule vWF could contribute to this increased thrombogenicity.  (+info)

Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation. (7/11)

 (+info)

Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing. (8/11)

 (+info)

AF is very rare in children so it would be no surprise if theres not much out there. If you want this question to remain open, you should edit it and add some of the information youve found so far because MedSci requires questions to demonstrate at least some level of prior research. - Carey Gregory♦ Nov 9 18 at 19:49 ...
TY - JOUR. T1 - Localization of atrial natriuretic peptide in normal human atrial tissue by immunoelectron microscopy. AU - Wei, Chi Ming. AU - Hukee, Margaret. AU - McGregor, Christopher G.A.. AU - Burnett, John C.. PY - 1993/12/1. Y1 - 1993/12/1. N2 - The study shows that atrial matriuretic peptide (ANP) is localized to secretory granules in normal human atrial tissue. This extends our understanding to the normal human of the biology of atrial regulation of this significant peptide of cardiac origin.. AB - The study shows that atrial matriuretic peptide (ANP) is localized to secretory granules in normal human atrial tissue. This extends our understanding to the normal human of the biology of atrial regulation of this significant peptide of cardiac origin.. UR - http://www.scopus.com/inward/record.url?scp=0027705543&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027705543&partnerID=8YFLogxK. M3 - Conference article. AN - SCOPUS:0027705543. SP - 316. EP - 317. JO - ...
Schlatzer, Christian; Kohler, Malcolm (2016). Apnoea-associated intrathoracic pressure swings create a dynamic arrhythmogenic atrial substrate during sleep: authors reply. Europace, 18(3):469.2-470. ...
Tokyo ― Terumo Corporation (TSE: 4543 Section 1) announced CE marking for the commercial sale of the Iberis™ Renal Sympathetic Denervation System, which the company has consigned product development to Shanghai AngioCare Medical Technology Co., Ltd. (hereinafter AngioCare) (Representative: Philip Wang), a Chinese company in renal sympathetic denervation technology for resistant hypertension treatment.. In December, 2012, Terumo formed a strategic alliance with AngioCare. Furthermore, the company has consigned product development to AngioCare and acquired the exclusive distribution rights for its renal sympathetic denervation technology on the global market.. Sales of Iberis in Europe will be commenced with its launch at the worlds leading cardiovascular intervention course, EuroPCR to be held in France in May, 2013.. Terumo aims to expand its renal sympathetic denervation business by launching Iberis in Asian and Latin American countries where the CE marked product is allowed for ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
The objective of this trial is to determine the efficacy and safety of adjunctive catheter-based renal sympathetic denervation (RSDN) in the primary prevention of ICD therapy in patients with ischemic or non-ischemic ventricular dysfunction, who are to receive an ICD for either i) secondary prevention, or ii) primary prevention + inducible VT by programmed ventricular stimulation at the time of ICD implantation. These patients will be randomized to ICD alone or ICD + RSDN ...
The objective of this trial is to determine the efficacy and safety of adjunctive catheter-based renal sympathetic denervation (RSDN) in the primary prevention of ICD therapy in patients with ischemic or non-ischemic ventricular dysfunction, who are to receive an ICD for either i) secondary prevention, or ii) primary prevention + inducible VT by programmed ventricular stimulation at the time of ICD implantation. These patients will be randomized to ICD alone or ICD + RSDN ...
Acupuncture Points location, description, functions, picture, acupuncture point chart. Look for specific acupuncture points and their uses. See pictures, charts and learn common uses and location.
TY - JOUR. T1 - Measurement of funny current (I(f)) channel mRNA in human atrial tissue. T2 - Correlation with left atrial filling pressure and atrial fibrillation. AU - Lai, Ling Ping. AU - Su, Ming Jai. AU - Lin, Jiunn Lee. AU - Tsai, Chang Her. AU - Lin, Fang Yue. AU - Chen, Yih Sharng. AU - Hwang, Juey Jen. AU - Stephen Huang, Shoei K.. AU - Tseng, Yung Zu. AU - Lien, Wen Pin. PY - 1999/1/1. Y1 - 1999/1/1. N2 - Introduction: The funny current (I(f)) contributes to phase IV spontaneous depolarization in cardiac pacemaker tissue. Enhanced I(f) activity in myocardial tissue may lead to increased automaticity and therefore tachyarrhythmia. We measured the amount of I(f) activity in the messenger ribonucleic acid (mRNA) in human atrial tissue and correlated the mRNA amount to left atrial filling pressure and atrial fibrillation (AF). Methods and Results: A total of 34 patients undergoing open heart surgery were included (15 men and 19 women, aged 55 ± 10 years). Atrial tissue was obtained from ...
This MATLAB function displays the vectors specified by U and V, where U contains the x components as relative coordinates, and V contains the y components as relative coordinates.
Full nutritional breakdown of the calories in Microwave Peanut Brittle based on the calories and nutrition in each ingredient, including Peanuts, dry-roasted, Granulated Sugar, Light Corn Syrup, Butter, salted, Vanilla Extract and the other ingredients in this recipe.
In this monograph Dr. Wenger has reviewed some 800 cases of endocardial fibro-elastosis from the literature and has reported 40 cases of his own. The result of his labors is a useful collection of data and references dealing with this poorly understood disorder. The author distinguishes five types of endocardial fibrotic change and divides his material therefore into these five major categories: (1) Endocardial fibro-elastosis, (2) Endomyocardial fibrosis, (3) Endocarditis parietalis fibroplastica, (4) Endocardial changes in the carcinoid syndrome, and (5) Secondary patchy endocardial fibrosis of the adult.. Irrespective of the validity of this division, these headings allow the author ...
Blood flow measurement using an improved surface integration of velocity vectors (SIVV) technique was tested in in vitro phantoms. SIVV was compared with true flow (12-116 mL/s) in a steady-state model using two angles of insonation (45 degrees and 60 degrees ) and two vessel sizes (internal diameter = 11 and 19 mm). Repeatability of the method was tested at various flow rates for each angle of insonation and vessel. In a univentricular pulsatile model, SIVV flow measured at the mitral inlet was compared to true flow (29-61 mL/s). Correlation was excellent for the 19-mm vessel (r(2)= 0.99). There was a systematic bias but close limits of agreement (mean +/- 2 SD = -24.1% +/- 7.6% at 45 degrees; +16.4% +/- 11.0% at 60 degrees ). Using the 11-mm vessel, a quadratic relationship was demonstrated between between SIVV and true flow (r(2) = 0.98-0.99), regardless of the angle of insonation. In the pulsatile system, good agreement and correlation were shown (r(2) = 0.94, mean +/- 2 SD = -4.7 +/- ...
In a preferred embodiment, drugs having heretofore unknown pharmacological properties which are useful in the medicinal therapy of fibrotic disease for the reparation and prevention of fibrotic lesional tissues, such drugs including as the active ingredient 5-methyl-1-phenyl-2-(1H)-pyridone. The pharmaceutical composition of this invention is novel as an anti-fibrotic drug, namely, as an agent for treating fibrosis. Any existing compounds have not been shown to be effective for the reparation and prevention of fibrotic lesions.
You are definitely on the right track. You can continue by first combining terms on the velocity so that you have the results in the form ai+bj+ck. The rate at which work is being done at any time is equal to the force F dotted with the velocity vector. Evaluate this dot product, and then integrate with respect to t. What is the formula for the change in KE in terms of the initial and the final velocity ...
Symple Surgical Inc., (SSI) is a developer of novel ablation technologies using controlled Microwave Energy. Symple Surgical innovation is for the treatment of resistant hypertension via renal sympathetic denervation. The DirectAblate Catheter delivers microwave energy to the depth-specific location of the sympathetic nerves while minimizing thermal exposure to non-targeted areas. Offices located in Northern California and Flagstaff, AZ.
TY - JOUR. T1 - Assessment of brachial artery mechanics using velocity vector imaging does not predict arteriovenous fistula failure; A feasibility study. AU - MacDonald, Conor James. AU - Ross, Rose. AU - Houston, John Graeme. PY - 2020/4/10. Y1 - 2020/4/10. N2 - Strain measurements by US have been suggested as a method of assessing arterial elasticity prior to arterio venous fistula creation. This pilot study sought to develop an imaging protocol to measure strain in the brachial artery via velocity vector imaging (VVI) and determine if differences in strain could be observed between a healthy group and a group with end-stage renal disease (ESRD), and if VVI measurements were associated with arterio-venous fistula malfunction. 40 healthy volunteers and 33 patients with ESRD were included in this study. All participants underwent US assessment of brachial artery strain via VVI. Peak velocity, strain, strain-rate and velocity were assessed. Patients with and without AVF failure at 3-months were ...
well, I found an equation of a= (v^2)/2 i, which gave an acceleration of a = 8 m/s i. I dont understand how this equation was derived. Although, now that I have actually thought about this, the acceleration vector around a curve or a circle always points toward the center of the circle and the velocity vector is always tangent to the point on the curve, so I understand how the acceleration vector is i and the velocity vector is j for x=-2,y=0. The only problem I have is the equation I came across ...
A method of controlling scar formation in humans by applying a force to tissue in an amount to create a wound; applying a lathyrogenic agent to the wound; forming the wound into a predetermined stationary or moveable beneficial configuration; and maintaining the wound in the predetermined configuration and in contact with lathyrogenic agent during healing.
Session VI - Recognizing Grey - controversial and ambiguous issues in cardiology. Chairpersons: J. J. Bax (Leiden, NL). B. Khandheria (Milwaukee, WI USA). 11:00 a.m. K. Narkiewicz (Gdańsk, PL). Hidden mechanisms of arterial hypertension. 11:30 a.m. J. J. Bax (Leiden, NL). Imaging to select patients for TAVI. 12:00 p.m. S. Q. Allaqaband (Milwaukee, WI USA). Interventions in structural heart disease. 12:30 p.m. F. Mahfoud (Homburg, D). Renal sympathetic denervation: should we go beyond resistant hypertension?. 01:00 p.m. M. Miglinas (Vilnius, LT). Blood pressure lowering and target organ protection: coherent or diverging effects?. 01:30 p.m. Concluding Remarks. Remigijus Zaliunas (Kaunas, LT). Rimvydas Slapikas (Kaunas, LT). Germanas Marinskis (Vilnius, LT). Zaneta Petrulioniene (Vilnius, LT ...
carbon dioxide angiography, chronic kidney disease (CKD), contrast nephropathy, renal sympathetic denervation, uncontrolled hypertension Background
Definition and Overview A keloid is a skin disorder subsequent from an abnormal or unnecessary development of scar tissue after a deep injury or wound has healed. It is a dermal fibrotic lesion ...
Study Flashcards On 6-04 msk/derm/vasc at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Identification of discrete surfaces. A: whole cardiac mesh [including atrial tissue] produced from Tetgen showing the tagged tetrahedral elements: myocardium (g
Since 2012, several cases of renal stenosis after renal denervation have been reported, demonstrating a wide spectrum of clinical presentation, but presenting recurrent hypertension as most relevant finding (1).. In the previous trials HTN-1 (Symplicity Renal Denervation in Patient With Refractory Hypertension) (2) and EnligHTN-I (Safety and Efficacy of Study of Renal Artery Ablation in Resistant Hypertension Patients) (3), renal artery stenosis had been attributed mainly to pre-existing artery stenosis worsening and not to a de novo procedure-related adverse event. The increasing reports of the last call into question the safety of this procedure and point to this complication as a possible cause of therapy ineffectiveness. ...
Methods and Results: We used a human atrial tissue model in heart failure and simulated propagation and spiral wave reentry with and without regionally proliferated fibroblasts. Coupling of fibroblasts to atrial myocytes resulted in shorter action potential duration, slower conduction velocity, and lower excitability. Consequently, heterogeneous fibroblast proliferation in the myocardial sheet resulted in frequent spiral wave breakups, and the bipolar electrograms recorded at the fibroblast proliferation area exhibited CFAEs. The simulations demonstrated that ablation targeting such fibroblast-derived CFAEs terminated AF, resulting from the ablation site transiently pinning the spiral wave and then pushing it out of the fibroblast proliferation area. CFAEs could not be attributed to collagen accumulation alone.. ...
Coarctation of the aorta is a narrowing of the descending aorta, which is typically located at the insertion of the ductus arteriosus just distal to the left subclavian artery (). This defect generally results in left ventricular pressure overload.Th
Mandache, E.; Gherghiceanu, M.; Macarie, C.; Kostin, S.; Popescu, L. M. (December 2010). "Telocytes in human isolated atrial ... tissue homoeostasis and remodelling/renewal. Figure 9. Human mammary gland stroma: TEM; original magnification 9,100x. A: ... amyloidosis: ultrastructural remodelling". Journal of Cellular and Molecular Medicine. 14 (12): 2739-2747. doi:10.1111/j.1582- ...
"Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling". The Journal of ... Ablation of sarcolipin increases atrial Ca2+ transient amplitudes and enhanced atrial contractility. Furthermore, atria from ... "Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility". Proceedings of the National ...
"Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovasc. Res. 83 (3): ...
October 2012). "Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction ... November 2010). "Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice". The Journal of Clinical ...
... selectively increases atrial refractory period by 22% in dogs with atrial tachycardia induced electrical remodeling. ... During atrial fibrillation this process becomes chaotic and the atrial depolarization occurs faster than it should causing the ... A recognized atrial selective drug target is Kv1.5, which is found in atria but not in ventricles. Kv1.5 carries the ultra ... Atrial fibrillation (AF) is an arrhythmia that occurs in 1-2% of the general population. AF is linked to several cardiac causes ...
This suggests that budiodarone may promote atrial re-modelling to improve malfunctioning ion channels that once potentiated ... "Amiodarone to prevent recurrence of atrial fibrillation. Canadian Trial of Atrial Fibrillation Investigators". The New England ... in patients with paroxysmal atrial fibrillation and pacemakers with atrial fibrillation data logging capabilities. Heart Rhythm ... A decrease in heart rate reduces the risk of atrial fibrillation. Preliminary trials of budiodarone have administered the drug ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ... Probably as a consequence of non-thyroidal illness syndrome, SPINA-GD predicts mortality in trauma and postoperative atrial ... Correlations were also shown to age, total atrial conduction time, and concentrations of 3,5-diiodothyronine and B-type ...
... of miR-590 by nicotine has been found to play a key part in the generation of atrial fibrosis by atrial structural remodelling ... "Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovascular Research. ...
pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ... Throughout life, the cardiac collagen skeleton is remodeled. Where collagen is diminished by age, calcium is often deposited, ... venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... The AV node is the only electrical conduit from the atria to the ventricles through the cardiac skeleton, which is why atrial ...
"Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs". ... In a porcine model of left atrial remodeling following mitral regurgitation, VLC-2 was shown to be upregulated. Human ALC-2 is ... Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans ... In a canine model of atrial fibrillation, decreased atrial contractility was associated with decreased ALC-2 and myosin binding ...
The recently remodeled atrium looks better than ever with its new and spacious gardens that are home to different types of ... Its pink stone facade has a tower composed of three bodies; there are cross atrial figures of the Passion of the Christ and of ...
A study showed a significant association of a specific polymorphism of the EDN2 gene with increased incidence of atrial ... Overall, the evidence suggests that ET-2 could modulate vascular tone, tissue morphology and remodelling. Since reports of ... December 2007). "A985G polymorphism of the endothelin-2 gene and atrial fibrillation in patients with hypertrophic ...
Atrial septostomy. Balloon septostomy. creation of septal defect in heart Blalock-Hanlon procedure. shunt from heart chamber to ... They also decrease cardiac oxygen demand and can prevent cardiac remodeling. Not all beta blockers are the same; some are ... including atrial fibrillation and atrial flutter. It is also used in the emergent treatment of wide complex tachycardias, ... It has been shown to be effective in acute cardioversion of recent-onset atrial fibrillation and atrial flutter. ...
Atrial septostomy is a surgical procedure that creates a communication between the right and left atria. It relieves pressure ... Importantly, right ventricular remodeling is associated with increased apoptosis; this is in contrast to pulmonary vascular ... This combination of vessel occlusion and vascular remodeling once again increases the resistance to blood flow and so the ... The mechanisms involved in this narrowing process include vasoconstriction, thrombosis, and vascular remodeling (excessive ...
One reason for this may be that once the heart has undergone atrial remodeling as in the case of chronic atrial fibrillation ... AF therefore have an increased chance of success with an ablation since their heart has not undergone atrial remodeling yet.[ ... For atrial flutter, single procedure success is 88% to 95% (95% CI) and multiple procedure success is 95% to 99% (95% CI). For ... For atrial fibrillation, several experienced teams of electrophysiologists in US heart centers claim they can achieve up to a ...
It is also believed that angiotensin directly affects cardiac remodeling, and blocking its activity can thereby slow the ... Glucocorticoids induce a potent diuresis in heart failure because they could improve renal responsiveness to atrial natriuretic ... It is also thought that catecholamines and other sympathomimetics have an effect on cardiac remodeling, and blocking their ... These commonly involve surgical left ventricular remodeling. The aim of the procedures is to reduce the ventricle diameter ( ...
... which leads to atrial remodeling and fibrosis, with loss of atrial muscle mass. This process occurs gradually, and experimental ... Valvular atrial fibrillation refers to atrial fibrillation attributable to moderate to severe mitral valve stenosis or atrial ... left atrial volume, size, and left ventricular hypertrophy, characteristic of chronic hypertension. All atrial remodeling is ... 193,300 with atrial flutter (2015)[10]. Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm (arrhythmia) ...
In vascular remodeling, Pcsk6 was found to induce smooth muscle cell migration in response to PDGFB by activating MMP14. When ... Pcsk6 KO mice was shown to develop salt-sensitive hypertension due to failure of pro-corin activation crucial to atrial ... "PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling". Circulation Research. 126 (5): ...
"2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial ... Left ventricular hypertrophy and left ventricular remodeling Diminished coronary flow reserve and silent myocardial ischemia ... often termed diastolic heart failure Atrial fibrillation, other cardiac arrhythmias, or sudden cardiac death Heart failure can ... hypertrophy in athletes Congestive heart failure or heart failure with normal ejection fraction due to other causes Atrial ...
These thickenings will go on to fuse and remodel to eventually form the valves and septa of the mature adult heart. A problem ... Upon sectioning of the heart the atrioventricular endocardial cushions can be observed in the lumen of the atrial canal as two ... As heart development continues, this tube undergoes remodeling to eventually form the four-chambered heart. The endocardial ... in endocardial cushion development or remodeling is thought to be associated with atrioventricular septal defect. Endocardial ...
Veno-occlusive remodelling[edit]. This theory proposes how high pulmonary venous pressures may lead to the capillary rupture ... pulmonary infection or atrial fibrillation, inflammation, longer distances, longer duration of exercise, hard surfaces, ... Other histopathologic findings include fibrosis, bronchial artery neovascularization, venous remodeling, bronchiolitis, ... with the venous remodeling leading to regional vascular congestion and hemorrhage, hemosiderin accumulation, fibrosis, and ...
For example, MMP9 appears to be involved in the remodeling associated with malignant glioma neovascularization. It is also a ... MMP9 levels increase with the progression of idiopathic atrial fibrillation. MMP9 has been found to be associated with the ... Gelatinase B plays a central role in tumor progression, from angiogenesis, to stromal remodeling, and ultimately metastasis. ... which are key effectors of ECM remodeling. MMP9, along with elastase, appears to be a regulatory factor in neutrophil migration ...
One reason for this may be that once the heart has undergone atrial remodeling as in the case of chronic atrial fibrillation ... AF therefore have an increased chance of success with an ablation since their heart has not undergone atrial remodeling yet. ... For atrial fibrillation, several experienced teams of electrophysiologists in US heart centers claim they can achieve up to a ... Risks of catheter ablation for atrial fibrillation include, but are not limited to: stroke, esophageal injury, pulmonary vein ...
... , also called atrial natriuretic peptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene. ... Corin-mediated ANP production in the pregnant uterus promotes spiral artery remodeling and trophoblast invasion. CORIN ... Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt- ... Wu F, Yan W, Pan J, Morser J, Wu Q (May 2002). "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes". The ...
Working on sino atrial node cells by inhibiting T-type calcium channel activation, Efonidipine prolongs the late phase-4 ... By reducing synthesis and secretion of aldosterone, Efonidipine prevents hypertrophy and remodeling of cardiac myocytes. ... depolarization of the sino atrial node action potential and suppresses an elevated HR. The negative chronotropic effect of ...
However, atrial natriuretic peptide is thought to be cardio-protective. Remodeling of the heart is evaluated by performing an ... Physiological remodeling is reversible while pathological remodeling is mostly irreversible. Remodeling of the ventricles under ... In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of ... This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling ...
The difference between aortic and right atrial pressure accounts for blood flow in the circulation.[16] When the left ventricle ... and then undergo a significant remodelling[11] to form the final asymmetrical structure of the great arteries, with the 3rd ...
Central venous pressure, which is a good approximation of right atrial pressure,[35] which is a major determinant of right ... In the longer term a process termed remodeling also contributes to changing the caliber of small blood vessels and influencing ... Mulvany, Michael J. (2012). "Small artery remodelling in hypertension". Basic & Clinical Pharmacology & Toxicology. 110 (1): 49 ... Tkachenko BI, Evlakhov VI, Poyasov IZ (2002). "Independence of changes in right atrial pressure and central venous pressure". ...
Left atrial dimension. LA. Range 24 - 40 mm[16] Fractional shortening (FS) is the fraction of any diastolic dimension that is ... pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ... venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... dimensions and relaxation in patients with atrial fibrillation". European Heart Journal. Suppl A: 149-56. PMID 7274225.. ...
A simplified form of this equation assumes right atrial pressure is approximately 0: CO ≈ MAP/TPR. The ideal blood pressure in ... RAP = right atrial pressure (in mmHg), the average pressure of blood as it returns to the heart ...
However, as the atrial baroreceptors increase their rate of firing and as they stretch due to the increased blood pressure, the ... There is a similar reflex, called the atrial reflex or Bainbridge reflex, associated with varying rates of blood flow to the ... This is important mainly in patients with atrial fibrillation, in whom heart beats are irregular and stroke volume is largely ...
With support from collagen, atrial fibrillation should never deteriorate to ventricular fibrillation. Collagen is layered in ... Collagenase, the enzyme involved in collagen breakdown and remodeling. *Hypermobility syndrome. *MMP inhibitors ...
Meinertz T, Willems S (December 2008). "[Treatment of atrial fibrillation in every days practice]" [Treatment of atrial ... and abnormal cardiac tissue remodeling, all of which decrease the efficiency of cardiac contraction and contribute to the low ... and prolonged atrial refractory periods. Sotalol, in particular, has additional antiarrhythmic properties and prolongs action ...
Atrial fibrillation - Atrial flutter - Premature contraction (Atrial, Ventricular) - Sick sinus syndrome. ... Ventricular remodeling. Dalerayan[mag-edit , alilan ya ing pikuwanan]. *↑ (2004) The World Health Report 2004 - Changing ...
Atrial *Septum primum. *Foramen secundum. *Primary interatrial foramen. *Septum secundum. *Foramen ovale ...
Practical Guide to Catheter Ablation of Atrial Fibrillation (2nd ed.). Wiley-Blackwell. pp. 65-73. ISBN 9781118658505.. .mw- ... "Ablation therapy for atrial fibrillation (AF): past, present and future". Cardiovascular research. 54 (2): 337-46. PMID ...
... and more recently as management of atrial fibrillation. The term is often used in the context of laser ablation, a process in ... laser is used to remodel the cornea refractive properties to correct refraction errors, such as astigmatism, myopia, and ...
... is the passage of fluid through the circulatory system or lymphatic system to an organ or a tissue,[1] usually referring to the delivery of blood to a capillary bed in tissue. Perfusion is measured as the rate at which blood is delivered to tissue,[2] or volume of blood per unit time (blood flow) per unit tissue mass. The SI unit is m3/(s·kg), although for human organs perfusion is typically reported in ml/min/g.[3] The word is derived from the French verb "perfuser" meaning to "pour over or through".[4] All animal tissues require an adequate blood supply for health and life. Poor perfusion (malperfusion), that is, ischemia, causes health problems, as seen in cardiovascular disease, including coronary artery disease, cerebrovascular disease, peripheral artery disease, and many other conditions. Tests verifying that adequate perfusion exists are a part of a patient's assessment process that are performed by medical or emergency personnel. The most common methods include evaluating a ...
See also: Atrial natriuretic peptide. REST/NRSF in conjunction with RE1/NRSE also acts outside the nervous system as regulators ... Current research has linked RE1/NRSE activity with the regulation of the expression of the atrial natriuretic peptide (ANP) ... Neuron-Restrictive Silencer Element-Neuron-Restrictive Silencer Factor System Regulates Basal and Endothelin 1-Inducible Atrial ...
... reducing atrial contractility and potentially contributing to atrial fibrillation.[25] Structural changes in T-tubules can lead ... as some suggest that T-tubule remodelling might be reversed through the use of interval training.[5] ... T-tubules are found in both atrial and ventricular cardiac muscle cells (cardiomyocytes), in which they develop in the first ... in 2009 an extensive T-tubule network in atrial cardiac muscle cells was observed.[25] Ongoing research focusses on the ...
Tan NY, Leong YY, Lang SS, Htoon ZM, Young SM, Sundar G (May 2017). "Radiologic Parameters of Orbital Bone Remodeling in ... George H. W. Bush, former U.S. president, developed new atrial fibrillation and was diagnosed in 1991 with hyperthyroidism due ... and progressive remodeling of the orbital walls.[21][22][23] Other distinctive features of TAO include lid retraction, ... atrial fibrillation), which may lead to stroke. If the eyes are proptotic (bulging) enough that the lids do not close ...
is the hematocrit; at that time, as during acceleration of the blood flow occurs a sharp decrease in the longitudinal resistance with small relaxation times. However, multiple factors affect blood resistivity. Erythrocyte aggregation occurs at low shear rates and implies that to all vessels (with the exception of large veins) the effect of aggregation is irrelevant. The interior of a blood vessel includes a near-wall layer of plasma (referred to as lubricant), the size of which strictly depends on Reynold's criterion and the shear rate of the flowing blood. Given that the thickness of this layer in all blood vessels (except capillaries) is less than 5 microns, and the resistivity of the plasma is two times less than in blood, then according to the scheme of parallel insertion, the contribution of this layer to the resistivity is negligible. By reducing the speed of blood flow profiles the dependence of Ht on the radius of the vessel becomes more elongated. However, at normal values of Ht, the ...
... coming from pig small intestine submucosa are being used to repair "atrial septal defects" (ASD), "patent ... Although the mechanism of action by which extracellular matrix promotes constructive remodeling of tissue is still unknown, ... "Remodelling the extracellular matrix in development and disease". Nature Reviews. Molecular Cell Biology. 15 (12): 786-801. ...
Central venous pressure/right atrial pressure → Right ventricular pressure → Pulmonary artery pressure → Pulmonary wedge ... pressure/left atrial pressure → Left ventricular pressure → Aortic pressure. Other. *Ventricular remodeling ...
... coming from pig small intestine submucosa are being used to repair "atrial septal defects" (ASD), "patent ... Although the mechanism of action by which extracellular matrix promotes constructive remodeling of tissue is still unknown, ... "Remodelling the extracellular matrix in development and disease". Nature Reviews. Molecular Cell Biology. 15 (12): 786-801. ... "Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling" ...
blood vessel remodeling. • cellular response to hypoxia. • heart valve development. • cellular response to estrogen stimulus. • ... atrial septum development. • regulation of heart rate. • DNA damage response, signal transduction by p53 class mediator ...
Atrial systole[edit]. Main article: Systole § Atrial systole. Atrial systole is the contracting of cardiac muscle cells of both ... such as caused by atrial fibrillation, atrial flutter, or heart block. Atrial kick may also be degraded by any deterioration in ... 2b Inflow: (Ventricular filling with Atrial systole#) open. closed. • ventricles relaxed and expanded; atrial contraction ( ... the atrial systole applies contraction pressure to 'topping-off' the blood volumes sent to both ventricles; this atrial kick ...
Atrial fibrillation and atrial flutter without rapid ventricular response. *Premature atrial contraction (PACs) and premature ... Atrial septostomy. Balloon septostomy. creation of septal defect in heart Blalock-Hanlon procedure. shunt from heart chamber to ... can indicate an ectopic atrial pacemaker. If the P wave is of unusually long duration, it may represent atrial enlargement. ... Atrial depolarization spreads from the SA node towards the AV node, and from the right atrium to the left atrium. The P wave is ...
"Radiologic Parameters of Orbital Bone Remodeling in Thyroid Eye DiseaseOrbital Bone Remodeling in Thyroid Eye Disease". ... George H. W. Bush, former U.S. president, developed new atrial fibrillation and was diagnosed in 1991 with hyperthyroidism due ... and progressive remodeling of the orbital walls.[19][20][21] Other distinctive features of TAO include lid retraction, ... atrial fibrillation), which may lead to stroke. If the eyes are proptotic (bulging) enough that the lids do not close ...
displaystyle {\frac {80\cdot (mean\ arterial\ pressure-mean\ right\ atrial\ pressure)}{cardiac\ output}}}. where mean arterial ... As an example: If Systolic pressure: 120 mmHg, Diastolic pressure: 80 mmHg, Right atrial mean pressure: 3 mmHg, Cardiac output ... and the pressure downstream from the occlusion is measured in order to approximately sample the left atrial pressure.[4] ...
The mechanism that leads to vasoconstriction results from the increased concentration of calcium (Ca2+ ions) within vascular smooth muscle cells.[2] However, the specific mechanisms for generating an increased intracellular concentration of calcium depends on the vasoconstrictor. Smooth muscle cells are capable of generating action potentials, but this mechanism is rarely utilized for contraction in the vasculature. Hormonal or pharmacokinetic components are more physiologically relevant. Two common stimuli for eliciting smooth muscle contraction are circulating epinephrine and activation of the sympathetic nervous system (through release of norepinephrine) that directly innervates the muscle. These compounds interact with cell surface adrenergic receptors. Such stimuli result in a signal transduction cascade that leads to increased intracellular calcium from the sarcoplasmic reticulum through IP3-mediated calcium release, as well as enhanced calcium entry across the sarcolemma through calcium ...
... is the study of the cardiovascular system, specifically addressing the physiology of the heart ("cardio") and blood vessels ("vascular"). These subjects are sometimes addressed separately, under the names cardiac physiology and circulatory physiology.[1] Although the different aspects of cardiovascular physiology are closely interrelated, the subject is still usually divided into several subtopics. ...
Atrial stretch induced by increased atrial pressure may precipitate atrial fibrillation through some effect on atrial ... Thus, it is possible that the elevation of atrial pressure might cause electrical remodeling by the upregulation of atrial AT1 ... However, long-term rapid atrial pacing might be necessary to examine the time course of atrial electrical remodeling and the ... Therefore, we continued rapid atrial pacing for 3 hours, which was enough to evaluate acute atrial electrical remodeling. In ...
Electrical Remodeling in Persistent Atrial Fibrillation May Be Mediated by Changes in the IKATP Channel *Taku Asano, MD, ... CONCLUSIONS: These data indicate that the electrical remodeling that occurs after cardioversion is at least partially mediated ...
... and such a remodeling has also been called atrial tachycardia remodeling.1,2,42,43 Atrial tachycardia remodeling is suggested ... Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to ... Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial- tachycardia remodeling in dogs. ... Background-A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated ...
During atrial fibrillation atrial remodeling takes place. Atrial remodeling refers to changes in the atria, including ... The aim of this thesis was to investigate this atrial remodeling. The focus is on remodeling caused by stretch (mimicking these ... First, different aspects of structural atrial remodeling are reviewed with a special focus on stretch and its contribution to ... Atrial fibrillation is the most common cardiac arrhythmia. Risk factors for atrial fibrillation include older age, hypertension ...
Left atrial (LA) enlargement is a common finding in hypertensive patients (pts), however little information is available on LA ... OBJECTIVES: Left atrial (LA) enlargement is a common finding in hypertensive patients (pts), however little information is ... hypertension showed a more marked increased of LA volumes compared to gestational hypertension due to a remodeling of atrial ...
... causes tachycardia-induced atrial electrical remodeling, contributing to the progressive nature of the arrhythmia. Ventricular ... dysfunction due to a rapid response to AF can cause structural remodeling, but whether ... OBJECTIVE: Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling, contributing to the progressive ... Atrial tissue from 1-week atrial-tachypaced dogs with ventricular rate control similarly showed upregulation of alpha SMA ...
... levels predict left atrial reverse remodeling after catheter ablation in patients with atrial fibrillation (AF) ... HealthDay News - Preprocedural serum atrial natriuretic peptide (ANP) levels predict left atrial reverse remodeling after ... "In this study, 47% of the patients exhibited left atrial reverse remodeling after RFCA for AF, with a concomitant improvement ... before RFCA and maintenance of sinus rhythm during follow-up were independent predictors of left atrial reverse remodeling ( ...
... cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial ... either of atrial or of ventricular origin, remains a major challenge. Sudden ... Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias. ... The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden ...
Thrombin promotes premature ageing and senescence of atrial ECs and may pave the way to deleterious remodeling of atrial tissue ... pro-fibrotic and pro-remodeling responses. Hence, targeting thrombin and/or angiotensin systems may efficiently prevent atrial ... Atrial endothelial senescence was induced by thrombin at clinically relevant concentrations. Thrombin induced the up-regulation ... We examined the potential of thrombin to promote premature atrial endothelial cells (ECs) senescence. Methods and Results: ...
Measurement of left atrial (LA) volume by the biplane area-length method where A2Ch and A4Ch refer to the LA area in the two- ... Background Left atrial (LA) size is an adverse prognostic marker. Aortic stenosis results in increased filling pressures with ... progressive left atrial enlargement and dysfunction. Intervention for aortic stenosis results in LV reverse remodelling, ...
... few data are available describing factors influencing changes in left atrial (LA) structure.Methods and Results-Maximum LA ... Background-Although contributors to remodeling of the left ventricle (LV) have been well studied in general population cohorts ... Background-Although contributors to remodeling of the left ventricle (LV) have been well studied in general population cohorts ... Associations of changes in LA volume (ΔLAV) with traditional risk factors, biomarkers, LV geometry, and remodeling by cardiac ...
Atrial Fibrillation. Atrial Remodeling. Vascular Diseases. Cardiovascular Diseases. Arrhythmias, Cardiac. Heart Diseases. ... Structural Remodeling (left atrial volume, left. *ventricular mass, left ventricular diastolic function. Evaluated at ... Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and ... Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension, Permanent ...
Atrial natriuretic peptide (ANP) reduces pulmonary vascular resistance and attenuates hypoxia-induced pulmonary hypertension in ... Measurement: pulmonary hypertension, right ventricular hypertrophy, and pulmonary arterial and alveolar remodeling were ... to test the hypothesis that ANP modulates the pulmonary vascular and alveolar remodeling response to normobaric hypoxic stress ... resulting in pulmonary vascular remodeling characterized by hyperplasia of pulmonary arterial smooth muscle cells (PASMCs) and ...
Defining biological markers of atrial remodelling would help identify patients at high risk who would benefit most from ... Biomarkers of atrial fibrillation progression would be helpful for following patients that present with asymptomatic atrial ... Notably, the roles of such markers in the pathophysiology of atrial fibrillation must be determined. Some markers may indicate ... Although a number of markers have been reported as potential predictors of paroxysmal atrial fibrillation progression towards ...
Atrial fibrillation begets atrial fibrillation: autonomic mechanism for atrial electrical remodeling induced by short-term ... seem to play a more relevant role for atrial electrical remodeling during AF. Atrial electrical remodeling results mainly from ... Renal Sympathetic Denervation Provides Ventricular Rate Control But Does Not Prevent Atrial Electrical Remodeling During Atrial ... Renal Sympathetic Denervation Provides Ventricular Rate Control But Does Not Prevent Atrial Electrical Remodeling During Atrial ...
1999) Promotion of atrial fibrillation by heart failure in dogs Atrial remodeling of a different sort. Circulation, 100, 87-95 ... 1999) Promotion of atrial fibrillation by heart failure in dogs: Atrial remodeling of a different sort. Circulation, 100, 87-95 ... symptomatic atrial fibrillation and heart failure. Randomized studies and observational data suggest that atrial fibrillation ... TITLE: Atrial fibrillation ablation in patients with heart failure review. AUTHORS: Mohammad I. Amin, Laurence D. Sterns, ...
Whether increased MMP activity directly contributes to atrial remodeling and AF in the setting of HF remains unclear. The ... play a role in extracellular remodeling, and recent studies have demonstrated increased atrial MMP activity in HF. ... The SAVP-MMPi dogs had significantly smaller increases in atrial myocyte cross sectional area, collagen area fraction, and MMP- ... current study examined the effects of MMP inhibition on atrial structural remodeling and AF vulnerability during HF progression ...
Background The contribution of progressive left atrial (LA) enlargement to elevated pulmonary capillary wedge pressure (PCWP) ... Association of echocardiographic atrial size and atrial fibrosis in a sequential model of congestive heart failure and atrial ... Effects of quinapril on left atrial structural remodeling and arterial stiffness. Am J Cardiol. 2006;97(6):916-20.CrossRef ... Contribution of the left atrial remodeling to the elevated pulmonary capillary wedge pressure in patients with WHO Group II ...
Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation. 1999;100:87-95. ... Electrical remodeling of the human atrium: similar effects in patients with chronic atrial fibrillation and atrial flutter. J ... Reverse atrial electrical remodelling following atrial defibrillation as determined by signal-averaged ECG. Can J Cardiol. 2004 ... Relevance of Electrical Remodeling in Human Atrial FibrillationClinical Perspective. Results of the Asymptomatic Atrial ...
... worlds leading medical scientists to share in a highly interactive environment the most recent advances in the field of atrial ... ionic remodeling and atrial fibrosis. Atrial fibrosis itself adds back to this, and results in persistent atrial fibrillation. ... Impact of atrial remodeling on AF outcomes 2013-10-01 Marking the very first presentation of the 2015 AF Symposium, Prashanthan ... Left atrial pressure and pulmonary artery pressure increased, and left atrial size increased, although the animals were too big ...
Left Atrial Remodeling Not Found After 1 Year of Nocturnal HD While left ventricular mass has been shown to regress with ...
Nattel S, Burstein B, Dobrev D. Atrial remodelling and atrial fibrillation: mechanisms and implications. Circ Arrhythmia ... ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes; Cardiovasc Res. 2007 Oct 26; [ ... Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circ ... ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res. 2008; 77: 35- ...
Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs ... Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation. Publication. ... atrial fibrillation, mitochondria, MCU, Ru360, SS31 Persistent URL. dx.doi.org/10.3390/cells8101202, hdl.handle.net/1765/122262 ... Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation. Cells, 8(10). ...
Left atrial remodelling in patients with successful percutaneous mitral valvuloplasty: determinants and impact on long-term ... Left atrial remodelling in patients with successful percutaneous mitral valvuloplasty: determinants and impact on long-term ... Background Left atrial (LA) volume is an independent prognosticator in various cardiac diseases. The authors assessed the ... the presence of atrial fibrillation and post-PMV LA volume. On multiple regression analysis, pre-PMV LA volume and percentage ...
Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation: Data of the RACE II ( ... Is lenient rate control associated with more adverse cardiac remodeling than strict rate control in patients with atrial ... Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation: Data of the RACE II ( ... It is possible that adverse remodeling would have occurred in this group if the resting rate had been closer to 110 bpm, ...
... remodeling and fibrosis in paroxysmal atrial fibrillation (AF) using speckle tracking echocardiography (STE) based on the ... This study aimed to evaluate left atrial (LA) ... Assessment of left atrial remodeling in paroxysmal atrial ... Hong J, Gu X, An P, Luo T, Lv Q, Kang J, He Y, Hu R, Liu X, Ma C (2013) Left atrial functional remodeling in lone atrial ... Li D, Fareh S, Leung TK, Nattel S (1999) Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a ...
Gap Junction Remodelling in Atrial Myocardium of Patients with Chronic Atrial Fibrillation-Relevance to Clinical Course Riyaz A ... Gap Junction Remodelling in Atrial Myocardium of Patients with Chronic Atrial Fibrillation-Relevance to Clinical Course. Clin ...
... induced atrial structural and electrical remodeling and contributes to AF perpetuation. BACKGROUND Galectin-3 (Gal-3) mediates ... The Gal-3 inhibitor GM-CT-01 (GMCT) reduced both Gal-3 and TGF-β1-induced sheep atrial fibroblast migration and proliferation ... and also mitigated atrial dilatation, myocyte hypertrophy, fibrosis, and the expected increase in dominant frequency of ... intracardiac serum Gal-3 levels were greater in persistent than paroxysmal AF and independently predicted atrial ...
RAA = right atrial appendage; RAFW = right atrial free wall; LAA = left atrial appendage; LAFW = left atrial free wall. ... of the right atrial appendage and intra-atrial conduction time (CT) from the right atrial appendage to the lower right atrial ... 1999) Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation 100:87-95. ... 2002) Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure. Cardiovasc Res ...
Serial monitoring of reverse left-atrial remodeling after pulmonary vein isolation in patients with atrial fibrillation: A ... Download PDF Serial monitoring of reverse left-atrial remodeling after pulmonary vein isolation in patients with atrial ... Serial monitoring of reverse left-atrial remodeling after pulmonary vein isolation in patients with atrial fibrillation: A ... PURPOSE: To prospectively determine the impact of sinus rhythm restoration on left-atrial (LA) volumes and function assessed by ...
  • Atrial fibrillation is the most common cardiac arrhythmia. (rug.nl)
  • Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling. (biomedsearch.com)
  • The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. (frontiersin.org)
  • Associations of changes in LA volume (ΔLAV) with traditional risk factors, biomarkers, LV geometry, and remodeling by cardiac magnetic resonance imaging and detailed measurements of global and regional adiposity (by magnetic resonance imaging and dual-energy x ray absorptiometry) were assessed using multivariable linear regression. (ovid.com)
  • AHRE are felt to be a precursor to AF, and may be both the result and a cause of changs in the atrial electrophysiology, and structure (known as cardiac remodeling)that are associated with the development of AF. (clinicaltrials.gov)
  • The cardiac atria are chambers of active remodeling and dynamic collagen turnover during evolving heart failure. (springer.com)
  • Background Left atrial (LA) volume is an independent prognosticator in various cardiac diseases. (bmj.com)
  • Is lenient rate control associated with more adverse cardiac remodeling than strict rate control in patients with atrial fibrillation (AF)? (acc.org)
  • Lenient rate control does not promote adverse cardiac remodeling in patients with persistent AF. (acc.org)
  • PURPOSE: To prospectively determine the impact of sinus rhythm restoration on left-atrial (LA) volumes and function assessed by cardiac magnetic resonance (CMR) imaging within the first year after pulmonary vein isolation (PVI). (uzh.ch)
  • These data suggest that there is a direct, partly BP-independent effect of RDN on cardiac remodeling and occurrence of premature atrial contractions. (onlinejacc.org)
  • Cardiac pressure overload results in cardiac remodeling including myocardial hypertrophy, diastolic dysfunction, and left atrial (LA) enlargement. (onlinejacc.org)
  • Cathepsin-L contributes to cardiac repair and remodelling post-infarction. (semanticscholar.org)
  • Additionally, they exhibit specific functions, as seen in Table 1, and highly homogeneous atrial- and ventricular-like myocytes are very helpful for drug safety, cardiac evaluation, and heart infarction cell therapies. (news-medical.net)
  • It is possible to use the programmed differentiation of atrial- and ventricular-like myocytes for the development of safe cell sources for individual treatment and cardiac repair that is personalized. (news-medical.net)
  • Postoperative atrial fibrillation (AF) is the most common arrhythmia following cardiac surgery with extracorporeal circulation. (frontiersin.org)
  • Reactive oxygen species (ROS)-derived effects could result in lipid peroxidation, protein carbonylation, or DNA oxidation of cardiac tissue, thus leading to functional and structural myocardial remodeling. (frontiersin.org)
  • The interplay between cardiac matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of MMPs (TIMPs), is thought to be critical in atrial extracellular matrix (ECM) metabolism. (elsevier.com)
  • A system and method for managing and inhibiting cardiac remodeling in MI patients. (google.com)
  • 2. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 1 , wherein the pulse is excitatory. (google.com)
  • 4. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 1 , wherein a compromised area of cardiac tissue has stem cells deposited thereon. (google.com)
  • 5. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 4 , wherein the LV and RV electrodes are located so as to electrically stimulate the compromised area of cardiac tissue on which stem cells have been deposited. (google.com)
  • The uncertainty concerning the onset and the extent of cardiac remodeling in response to intensive training hinders medical evaluation by physician. (clinicaltrials.gov)
  • A better knowledge of the physiology of cardiac adaptation to training will enable physicians to correctly determine whether observed patterns of cardiac remodeling are physiological or pathological. (clinicaltrials.gov)
  • This prospective study proposes to assess in a trained-athlete population the cardiac remodeling in response to intensive exercise training. (clinicaltrials.gov)
  • Rationale: Fibroblasts are involved in cardiac arrhythmogenesis and contribute to the atrial fibrillation substrate in congestive heart failure (CHF) by generating tissue fibrosis. (fujita-hu.ac.jp)
  • Maladaptive remodeling of K + channels associated with cardiac and systemic diseases results in impaired repolarization and increased propensity for arrhythmias. (pubmedcentralcanada.ca)
  • Here, we review the diverse transcriptional, post-transcriptional, post-translational and epigenetic mechanisms contributing to regulating the expression, distribution and remodeling of cardiac K + channels under physiological and pathological conditions. (pubmedcentralcanada.ca)
  • The study aimed to investigate the intermediate-term effects of transcatheter atrial septal defect (ASD) closure on cardiac remodeling in children and adult patients. (erciyes.edu.tr)
  • In recent years, growing evidence suggests an association between obstructive sleep apnea (OSA), a common sleep breathing disorder which is increasing in prevalence as the obesity epidemic surges, and atrial fibrillation (AF), the most common cardiac arrhythmia. (hindawi.com)
  • However, their role in age-related cardiac remodeling and atrial fibrillation (AF) was not well understood. (bvsalud.org)
  • AF progression is driven by abnormalities in electrical impulse formation and contractile function due to structural remodeling of cardiac tissue. (vumc.nl)
  • Circulating microRNAs may reflect or influence pathological cardiac remodeling and contribute to atrial fibrillation (AF). (bvsalud.org)
  • Left atrial size is a known risk factor providing prognostic information in several cardiac conditions. (elsevier.com)
  • Cine cardiac magnetic resonance (cine-CMR) provides excellent endocardial delineation, enabling accurate quantification of left atrial (LA) chamber size. (biomedcentral.com)
  • Fibronectin containing the extra domain A (ED-A + Fn) was proven to serve as a valuable biomarker for cardiac remodeling. (hindawi.com)
  • This so-called myocardial remodeling initially enables compensatory mechanisms to maintain cardiac function despite the persisting pathologic stimuli. (hindawi.com)
  • Myocardial remodeling is a complex and heterogeneous process involving cardiac myocyte alterations, activation of fibroblasts, and transdifferentiation to myofibroblasts (MyoFb) as well as a dynamic functional and structural reorganization of the cardiac extracellular matrix (cECM) [ 2 , 4 - 6 ]. (hindawi.com)
  • Each chapter deals with a different aspect of Atrial Fibrillation and was authored by internationally recognized experts in the evolving field of cardiac electrophysiology. (springer.com)
  • Because Atrial Fibrillation is so prevalent and affects all areas of medicine, the information in this book will be useful to cardiologists, cardiac surgeons, researchers, and all those in the medical field. (springer.com)
  • heart , atrial fibrillation (AF) and atrial flutter (Aflut), occur frequently after most types of cardiac surgeries. (bioportfolio.com)
  • This study will be a retrospective cohort analysis of all patients that underwent elective cardiac surgeries between 2000-2005 at Emory University Hospital, Crawford Long Hospital, or the Atlanta Veterans Affairs Medical Center to evaluate the relationship of pre-operative TZD use to the incidence of post-operative atrial arrhythmias. (bioportfolio.com)
  • Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting approximately 1% of the population. (kit.edu)
  • In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of the heart. (wikipedia.org)
  • The cardiac myocyte is the major cell involved in remodeling. (wikipedia.org)
  • The initial remodeling phase after a myocardial infarction results in repair of the necrotic area and myocardial scarring that may, to some extent, be considered beneficial since there is an improvement in or maintenance of LV function and cardiac output. (wikipedia.org)
  • Besides, reduced expression of V1 mysoin and L-type calcium channels on cardiac myocytes are also thought to cause cardiac remodelling. (wikipedia.org)
  • Besides, the cardiac interstitium which consisted of largely Type I and Type III collagen fibres are also involved in cardiac remodeling. (wikipedia.org)
  • Other factors such as high blood pressure, activation of sympathetic system which releases norepinephrine, activation of renin-angiotensin system which releases renin and anti-diuretic hormones are important contributors of cardiac remodelling. (wikipedia.org)
  • Pedersen et al 6 observed that ACEI reduced the incidence of atrial fibrillation in patients with left ventricular dysfunction after acute myocardial infarction, but they did not show the underlying mechanism of their finding. (ahajournals.org)
  • Ventricular dysfunction due to a rapid response to AF can cause structural remodeling, but whether AF itself directly promotes atrial fibrosis is controversial. (biomedsearch.com)
  • Measurement: pulmonary hypertension, right ventricular hypertrophy, and pulmonary arterial and alveolar remodeling were assessed. (ovid.com)
  • The effect of modulation of the autonomic nervous system by RDN on atrial electrophysiology and ventricular rate control during atrial fibrillation (AF) is unknown. (ahajournals.org)
  • Subsequently, we investigated the effect of RDN on AF-induced shortening of atrial effective refractory period, AF inducibility, and ventricular rate control during AF maintained by rapid atrial pacing in 12 pigs undergoing RDN (n=7) or sham procedure (n=5). (ahajournals.org)
  • Atrial fibrilla- tion ablation is relatively safe and may result in improvement of left ventricular function and quality of life. (scirp.org)
  • Going back to Dr Nattel's work with substrates in AF, he continued: "This is the ventricular pacing model of heart failure, where they were able to show that in the atria there is an increased amount of atrial fibrosis associated with conduction heterogeneity, and increase of the duration of atrial fibrillation. (afsymposium.com)
  • Key Results: Whilst ventricular parameters and functions were unchanged in cancer patients pre- and post-chemotherapy, strain and strain rate of left atrial reservoir function and conduit function were decreased at 3 months post-chemotherapy vs pre-chemotherapy. (authorea.com)
  • Doxorubicin-induced atrial dilatation and susceptibility to AF occurred in mice prior to onset of ventricular dysfunction. (authorea.com)
  • Most are distinguished by spontaneous beating, exhibiting a wide range of depolarization-repolarization patterns, potentially indicating mixed populations of atrial and ventricular myocytes . (news-medical.net)
  • Which is more important: atrial or ventricular myocytes? (news-medical.net)
  • The muscular walls of the heart, also known as the myocardium, are formed from atrial and ventricular cardiomyocytes. (news-medical.net)
  • Differences can be seen in atrial myocyte ultrastructure when compared to ventricular myocytes. (news-medical.net)
  • Atrial and ventricular cardiomyocytes have differential gene expression patterns concerning, for example, transcription factors, structural proteins, and ion channels. (news-medical.net)
  • Differential gene expression pattern displays in atrial and ventricular cardiomyocytes. (news-medical.net)
  • Although there are effective therapies available for common disorders of atrial cardiomyocytes, like atrial fibrillation, loss of ventricular cardiomyocytes as a result of myocardial infarction is unable to be successfully treated. (news-medical.net)
  • Recent research using the atria of zebrafish suggests that the activation of Notch signa-ling as a response to ventricle ablation is essential for the reprogramming of atrial cardiomyocytes into ventricular cardiomyocytes. (news-medical.net)
  • It is proposed from this study that heart regeneration in zebrafish can be attained by transdifferentiation of differentiated atrial cardiomyocytes into ventricular cardiomyocytes. (news-medical.net)
  • A detailed understanding of the molecular and functional variances between atrial and ventricular cardiomyocytes is helpful in defining novel techniques for applications of embryonic stem cells (ESCs), as well as providing cellular models for research into genetic atrial- or ventricular-related diseases. (news-medical.net)
  • Although connexin changes are important for the ventricular arrhythmic substrate in congestive heart failure (CHF), connexin alterations during CHF-related atrial arrhythmogenic remodeling have received limited attention. (ahajournals.org)
  • Left ventricular (LV) end-diastolic pressure and atrial refractory periods increased with CHF and normalized on CHF recovery. (ahajournals.org)
  • 2 The atria of dogs with ventricular tachypacing-induced CHF are characterized by structural remodeling, conduction abnormalities and the ability to sustain AF. (ahajournals.org)
  • We previously noted that the cessation of ventricular tachypacing, which is followed by the reversal of CHF, dissociates atrial size and function changes from structural remodeling and AF sustainability. (ahajournals.org)
  • Methods and Results: Freshly isolated left atrial fibroblasts were obtained from controls and dogs with CHF (ventricular tachypacing). (fujita-hu.ac.jp)
  • Atrial fibrillation (AF) often occurs in Brugada syndrome (BrS), and BrS patients with spontaneous AF often experience ventricular fibrillation (VF) attacks. (cdc.gov)
  • Left atrial volume index (LAVI) was measured by the modified Simpson method at left ventricular end-systole using echocardiography. (cdc.gov)
  • An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. (google.es)
  • The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling. (google.es)
  • 3 The method of claim 1 further comprising changing the ventricular pacing site in accordance with activity level measurements reflective of metabolic demand so that the pacing site is alternated between one designed to produce hemodynamically more effective contractions when metabolic needs of the body are great to one designed for remodeling reversal when metabolic needs are less. (google.es)
  • 4 . The method of claim 1 further comprising delivering pacing pulses to a plurality of ventricular sites as defined by a specified pulse output configuration and in accordance with a defined pulse output sequence which begins after the AV pacing delay interval following an atrial sense or pace. (google.es)
  • The role of the protease cathepsin A for the progression of left ventricular remote remodeling and atrial cardiomyopathy in ischemic cardiomyopathy is unknown. (onlinejacc.org)
  • In rats with ventricular ischemia and reperfusion, cathepsin A is up-regulated in the left ventricular and atrial tissue remote from the infarcted area. (onlinejacc.org)
  • Pharmacological inhibition of cathepsin A protease activity by SAR significantly reduces remote ventricular remodeling and atrial extracellular matrix remodeling, represented by fibrosis formation and connexin 43 lateralization. (onlinejacc.org)
  • Prevention of ventricular remote remodeling and atrial cardiomyopathy by SAR increased ventricular viable myocardium and atrial emptying function reducing susceptibility to atrial fibrillation. (onlinejacc.org)
  • Remote ventricular and atrial extracellular matrix remodeling may represent a promising target for pharmacological atrial fibrillation upstream therapy following myocardial infarction. (onlinejacc.org)
  • After myocardial infarction, remote ventricular remodeling and atrial cardiomyopathy progress despite successful revascularization. (onlinejacc.org)
  • In a rat model of ventricular ischemia/reperfusion, pharmacological inhibition of the protease activity of cathepsin A initiated at the time point of reperfusion prevented extracellular matrix remodeling in the atrium and the ventricle remote from the infarcted area. (onlinejacc.org)
  • This scenario was associated with preservation of more viable ventricular myocardium and the prevention of an arrhythmogenic and functional substrate for atrial fibrillation. (onlinejacc.org)
  • Remote ventricular extracellular matrix remodeling and atrial cardiomyopathy may represent a promising target for pharmacological atrial fibrillation upstream therapy following myocardial infarction. (onlinejacc.org)
  • Pizzale S., Gollob M.H., Gow R., Birnie D.H. Sudden death in a young man with catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation. (pmarchive.ru)
  • Time course of right ventricular remodeling after percutaneous atrial septal defect closure: assessment of regional deformation properties with two-dimensional strain and strain rate imaging. (docphin.com)
  • Eroglu E, Cakal SD, Cakal B, Dundar C, Alici G, Ozkan B, Yazicioglu MV, Tigen K, Esen AM. Time course of right ventricular remodeling after percutaneous atrial septal defect closure: assessment of regional deformation properties with two-dimensional strain and strain rate imaging. (docphin.com)
  • Quantitative assessment of the right ventricular (RV) function in atrial septal defect (ASD) patients before and after closure remains difficult. (docphin.com)
  • Results: Preoperative left atrial dilation was associated with left ventricular hypertrophy and increased filling pressure. (elsevier.com)
  • Preoperative left atrial volume index was associated with persistent abnormalities in left ventricular filling pressure and left ventricular mass index at 1 year after surgery. (elsevier.com)
  • At later stages, the remodeling process proceeds to left ventricular dysfunction with the clinical consequence of the heart failure syndrome. (hindawi.com)
  • Furthermore, the morphologic repercussions of NVAF, including left atrium dilation and left ventricular systolic dysfunction, as well as the presence of left atrial appendage stasis indicators, could also help refine the risk stratification. (bioportfolio.com)
  • Aetna considers the Batista ventricular remodeling procedure, also known as partial left ventriculectomy, experimental and investigational because its effectiveness has not been established. (aetna.com)
  • The ventricular remodeling operation (also known as the Batista procedure, partial left ventriculectomy, heart reduction surgery, and wedge resection of the heart) has been proposed as a surgical procedure to replace or postpone heart transplantation in patients with dilated non-ischemic cardiomyopathy. (aetna.com)
  • Ventricular Remodeling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Ventricular Remodeling" by people in Harvard Catalyst Profiles by year, and whether "Ventricular Remodeling" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Ventricular Remodeling" by people in Profiles. (harvard.edu)
  • Insulin Resistance Modifies the Effects of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction (from the OMEGA-REMODEL Randomized Clinical Trial). (harvard.edu)
  • Coronary Microvascular Dysfunction, Left Ventricular Remodeling, and Clinical Outcomes in Patients With Chronic Kidney Impairment. (harvard.edu)
  • These compensatory mechanisms include neurohormonal activation, increased contractility, vasoconstriction, and ventricular hypertrophy and remodeling. (medscape.com)
  • Natriuretic peptides counteract vasoconstriction and are released upon atrial or ventricular stretch. (medscape.com)
  • Ultimately, ventricular remodeling may result in diminished contractile (systolic) function and reduced stroke volume. (wikipedia.org)
  • The term "reverse remodeling" in cardiology implies an improvement in ventricular mechanics and function following a remote injury or pathological process. (wikipedia.org)
  • The purpose of this study is to determine whether irbesartan will reduce the rate of recurrent atrial high rate episodes and the development of clinical sustained atrial fibrillation in patients with hypertension and permanent pacemaker. (clinicaltrials.gov)
  • OBJECTIVES To determine whether Gal-3 mediates sustained atrial fibrillation (AF)-induced atrial structural and electrical remodeling and contributes to AF perpetuation. (semanticscholar.org)
  • HealthDay News - Preprocedural serum atrial natriuretic peptide (ANP) levels predict left atrial reverse remodeling after catheter ablation in patients with atrial fibrillation (AF), according to a study published online March 23 in JACC: Clinical Electrophysiology . (empr.com)
  • This study aimed to evaluate left atrial (LA) remodeling and fibrosis in paroxysmal atrial fibrillation (AF) using speckle tracking echocardiography (STE) based on the findings with radiofrequency catheter ablation (RFCA) so as to predict atrial remodeling prior to ablation. (springer.com)
  • Nademanee K, Lockwood E, Oketani N, Gidney B (2010) Catheter ablation of atrial fibrillation guided by complex fractionated atrial electrogram mapping of atrial fibrillation substrate. (springer.com)
  • Morris DA, Parwani A, Huemer M, Wutzler A, Bekfani T, Attanasio P, Friedrich K, Kuhnle Y, Haverkamp W, Boldt LH (2013) Clinical significance of the assessment of the systolic and diastolic myocardial function of the left atrium in patients with paroxysmal atrial fibrillation and low CHADS(2) index treated with catheter ablation therapy. (springer.com)
  • Mirza M, Caracciolo G, Khan U, Mori N, Saha SK, Srivathsan K, Altemose G, Scott L, Sengupta P, Jahangir A (2011) Left atrial reservoir function predicts atrial fibrillation recurrence after catheter ablation: a two-dimensional speckle strain study. (springer.com)
  • Plasma galectin-3 predicts clinical outcomes after catheter ablation in persistent atrial fibrillation patients without structural heart disease. (semanticscholar.org)
  • While understanding left atrial wall thickness around PVs (PVWT) prior to catheter ablation is important, its clinical implications are not known. (yonsei.ac.kr)
  • We assessed the effects of catheter ablation of PVCs on parameters of LV diastolic function and LA remodeling. (elsevier.com)
  • Conclusion: Catheter ablation of PVCs improved LV diastolic function and resulted in left atrial reverse remodeling. (elsevier.com)
  • Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients. (elsevier.com)
  • PR Interval Associated Genes, Atrial Remodeling and Rhythm Outcome of Catheter Ablation of Atrial Fibrillation-A Gene-Based Analysis of GWAS Data. (cdc.gov)
  • PR interval prolongation has recently been shown to associate with advanced left atrial remodeling and atrial fibrillation (AF) recurrence after catheter ablation. (cdc.gov)
  • While different genome-wide association studies (GWAS) have implicated 13 loci to associate with the PR interval as an AF endophenotype their subsequent associations with AF remodeling and response to catheter ablation are unknown. (cdc.gov)
  • Here, we perform a gene-based analysis of GWAS data to test the hypothesis that PR interval candidate genes also associate with left atrial remodeling and arrhythmia recurrence following AF catheter ablation. (cdc.gov)
  • Of those, ITGA9 and SOX5 were significantly associated with left atrial low voltage areas and left atrial diameter and subsequently with AF recurrence after radiofrequency catheter ablation. (cdc.gov)
  • This study suggests contributions of ITGA9 and SOX5 to AF remodeling expressed as PR interval prolongation, low voltage areas and left atrial dilatation and subsequently to response to catheter ablation. (cdc.gov)
  • Dr Nattel's work has kindly demonstrated the central role of atrial fibrosis in the mechanistic method of this substrate for atrial fibrillation. (afsymposium.com)
  • Whether it is with ageing, heart failure, hypertension or mitral regurgitation, these result in atrial stretch, ionic remodeling and atrial fibrosis. (afsymposium.com)
  • Atrial fibrosis itself adds back to this, and results in persistent atrial fibrillation. (afsymposium.com)
  • There is clear evidence to suggest that AF feeds back on itself to remodel this process, and there is even a suggestion that it may induce further atrial fibrosis. (afsymposium.com)
  • He added: "We have now evaluated a number of conditions, both in the clinic and in the preclinical scenario, and it seems fairly uniform that the substrate that predisposes to atrial fibrillation is structural changes, be they interstitial fibrosis,low-voltage and scarring - the result is abnormal conduction. (afsymposium.com)
  • (1) observed that the activation of angiotensin-converting enzyme (ACE)-dependent extracellular signal-regulated kinases (Erk1/Erk2) was involved in the mechanism of the development of atrial fibrosis in patients with AF. (onlinejacc.org)
  • It is well known that architectural alterations of the atria, including atrial dilation and tissue fibrosis, are associated with atrial dysfunction (5,6) . (onlinejacc.org)
  • (6) reported that electrical heterogeneity probably due to atrial fibrosis might play a critical role in the induction and promotion of AF in an arrhythmogenic substrate in the canine heart failure model. (onlinejacc.org)
  • Recent data show that interstitial fibrosis can predispose to atrial conduction impairment and AF induction. (elsevier.com)
  • We also describe the activation of bioactive molecules in both clinical studies and animal models to modulate MMPs and TIMPs and their effects on atrial fibrosis in AF. (elsevier.com)
  • Similar to observations seen in animals exposed to WNT-974, deletion of the collagen VI subunit, COL6A1 , has been shown to decrease aberrant remodeling and fibrosis in infarcted heart tissue. (nih.gov)
  • 11,12 Both structural (particularly tissue fibrosis) and connexin remodeling could contribute to CHF-associated AF. (ahajournals.org)
  • Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure. (qxmd.com)
  • Samples of atrial tissue showed the abnormal pathohistological and ultrastructural changes, the accelerated fibrosis , and apoptosis with aging and/or in AF dogs . (bvsalud.org)
  • Aims Left atrial (LA) fibrosis caused by various pathological stimuli is a common finding. (elsevier.com)
  • This study sought to determine whether chronic atrial fibrillation (AF) and atrial flutter in patients lead to electrical remodeling of the human atrial myocardium, manifested by an abnormal relation between atrial cycle length and action potential duration (APD). (onlinejacc.org)
  • Transcatheter ASD closure can reverse electrical and mechanical changes in atrial myocardium, resulting in a subsequent reduction in P maximum and P dispersion times. (erciyes.edu.tr)
  • Thus, if the refractory period of the atrial myocardium is short (i.e., faster recovery) or if the conduction time is so slow that the tissue can recover before the wavelet arrives, atrial fibrillation can develop. (aafp.org)
  • Atrial remodeling refers to changes in the atria, including structural changes such as an increase in atrial size. (rug.nl)
  • First, different aspects of structural atrial remodeling are reviewed with a special focus on stretch and its contribution to structural remodeling. (rug.nl)
  • In addition, this group of patients also affords the ability to evaluate the recurrence of AHRE on the progression of structural and electrical remodeling. (clinicaltrials.gov)
  • Atrial fibrillation is a heterogeneous disorder that is usually characterized by paroxysmal onset, particularly in patients without structural heart disease. (scirp.org)
  • Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs electrical activation of the atria, rendering them increasingly permissive to the arrhythmia. (eur.nl)
  • Objectives The purpose of the present study was to evaluate the effect of angiotensin II type 1 receptor (AT1R) antagonist on chronic structural remodeling in atrial fibrillation (AF). (onlinejacc.org)
  • However, the effect of candesartan on chronic structural remodeling in AF is unclear. (onlinejacc.org)
  • Conclusions Candesartan can prevent the promotion of AF by suppressing the development of structural remodeling. (onlinejacc.org)
  • However, the effects of these drugs on long-term atrial electrophysiologic and structural remodeling are still unclear. (onlinejacc.org)
  • Considering previous observations, we hypothesized that structural abnormalities caused by an activated renin-angiotensin system during chronic atrial activation might participate in the mechanisms of AF maintenance. (onlinejacc.org)
  • Doxorubicin-induced AF was via inducing structural remodeling (i.e. cardiomyocyte death, hypotrophy and vacuolization) and electrical remodeling (i.e. reduction and redistribution of connexin 43) in the atrium, which was effectively prevented by dexrazoxane. (authorea.com)
  • Electrical, contractile and structural remodeling have been characterized in atrial fibrillation (AF), and the latter is considered to be the major contributor to AF persistence. (elsevier.com)
  • Remodeling-induced fibroblast KCNJ2 expression changes may play a role in atrial fibrillation promoting fibroblast remodeling and structural/arrhythmic consequences. (fujita-hu.ac.jp)
  • In the present study we investigated the regulating effects of PPAR-γ agonist on AngII-induced atrial structural and electrical remodeling in vitro cellular models. (qxmd.com)
  • Atrial vulnerability providing a substrate for AF is known to be enhanced in BrS, but there are no data on atrial structural attributes. (cdc.gov)
  • The objective of this study was to assess atrial electrophysiological and structural characteristics in BrS and their relationships with gene mutations. (cdc.gov)
  • Both atrial vulnerability and structural remodeling are enhanced in high-risk patients with BrS, even in those without AF. (cdc.gov)
  • To investigate an association between left atrial (LA) structural and P wave dispersion (PWD) during sinus rhythm, and electrical remodeling in cryptogenic stroke (CS) patients . (bvsalud.org)
  • The present study was designed to decipher molecular mechanisms underlying age-related atrial structural remodeling and AF. (bvsalud.org)
  • However, LV remodeling due to structural and functional changes in the extracellular matrix (ECM) often progresses even following successful revascularization and is the most common reason for heart failure after myocardial infarction (3,4) . (onlinejacc.org)
  • Previous reports indicate that structural remodeling is rooted in derailment of protein homeostasis (proteostasis). (vumc.nl)
  • Whether these compounds also accelerate reversibility from structural remodeling in tachypaced cardiomyocytes is unknown. (vumc.nl)
  • Objective: To investigate whether the potent HSP inducer GGA*-59 restores structural remodeling and contractile dysfunction in tachypaced cardiomyocytes and explore the underlying mechanisms. (vumc.nl)
  • Conclusions: Our results imply that the HSP inducer GGA*-59 and recombinant HSPB1 accelerate recovery from TP-induced structural remodeling and contractile dysfunction in HL-1 cardiomyocytes. (vumc.nl)
  • Objectives This study hypothesized that left atrial structural remodeling (LA-TR) correlates with exercise capacity (EC) in a cohort of patients with atrial fibrillation (AF). (onlinejacc.org)
  • Model of minimum degree of complexity of ionic and structural remodeling that enhances the initiation and maintenance of atrial fibrillation in 2 common AF conditions (heart failure and aging). (ahajournals.org)
  • The authors concluded that PLV could provide structural remodeling of the heart that might result in temporary improvement in clinical compensation. (aetna.com)
  • The AF duration, atrial effective refractory period (AERP) at four sites in the RA, and intra-atrial conduction time (CT) from the RA appendage to the other three sites were measured every week. (onlinejacc.org)
  • CHF causes atrial connexin changes, but these are not essential for CHF-related conduction disturbances and AF promotion, which are rather related primarily to fibrotic interruption of muscle bundle continuity. (ahajournals.org)
  • We therefore exploited CHF reversal to assess the reversibility of atrial connexin alterations and evaluate their contribution to CHF-related conduction disturbances and AF maintenance. (ahajournals.org)
  • Intra-atrial conduction time (CT) was defined as the interval from the stimulus at the high right atrium to atrial deflection at the distal portion of the coronary sinus. (cdc.gov)
  • BACKGROUND: Rate-dependent conduction velocity (CV) slowing is associated with atrial fibrillation (AF) initiation and reentry mechanisms. (ucl.ac.uk)
  • Methods and Results -In 24 dogs, the atrial effective refractory period (AERP) was measured before, during, and after rapid atrial pacing. (ahajournals.org)
  • Rapid atrial pacing at 800 bpm was maintained for 180 minutes. (ahajournals.org)
  • Conclusions -The inhibition of endogenous Ang II prevented AERP shortening during rapid atrial pacing. (ahajournals.org)
  • Recent studies in animal models and humans have shown that atrial fibrillation induced by rapid atrial pacing itself produces shortening of the atrial effective refractory period (AERP) and reverses the normal physiological rate adaptation of refractoriness. (ahajournals.org)
  • This study investigated the hypothesis that rapid atrial cardiomyocyte activation produces factors that influence atrial fibroblast proliferation and secretory functions. (biomedsearch.com)
  • We previously reported that the blockade of angiotensin II (Ang II) prevented the electrical remodeling induced by short-term rapid atrial pacing (4) . (onlinejacc.org)
  • Three groups of dogs were studied adult and aged dogs in sinus rhythm and with persistent AF induced by rapid atrial pacing. (bvsalud.org)
  • Marking the very first presentation of the 2015 AF Symposium, Prashanthan Sanders from the Royal Adelaide Hospital, Australia, kickstarted proceedings on Thursday morning with an exploration of the mechanisms of atrial remodeling and their impact of AF outcomes. (afsymposium.com)
  • Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. (semanticscholar.org)
  • Lin, CS & Pan, CH 2008, ' Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation ', Cellular and Molecular Life Sciences , vol. 65, no. 10, pp. 1489-1508. (elsevier.com)
  • However, the underlying regulatory mechanisms of atrial remodeling remain unclear. (elsevier.com)
  • therefore neonatal rat atrial myocytes were subjected to cyclical stretch. (rug.nl)
  • Transverse t-tubules are a common feature in large mammalian atrial myocytes including human. (kompetenznetz-vorhofflimmern.de)
  • Objective: To determine the mechanisms underlying electrophysiological effects of palmitic (PA), stearic (SA) and oleic (OA) FFAs on sheep atrial myocytes. (umn.edu)
  • Methods: We used electrophysiological techniques, numerical simulations, biochemistry and optical imaging to examine the effects of acutely (≤ 15 min), short-term (4-6 hour) or 24-hour application of individual FFAs (10 μM) on isolated ovine left atrial myocytes (LAMs). (umn.edu)
  • Results: Acute and short-term incubation in FFAs resulted in no differences in passive or active properties of isolated left atrial myocytes (LAMs). (umn.edu)
  • Conclusions: SA disrupts t-tubular architecture and remodels properties of membrane ionic currents in sheep atrial myocytes, with potential implications in arrhythmogenesis. (umn.edu)
  • The influences of pioglitazone on AngII-induced L-type calcium channel (ICa-L) α1c expression and current density were evaluated in atrial myocytes (HL-1). (qxmd.com)
  • Pioglitazone improves potassium channel remodeling induced by angiotensin II in atrial myocytes. (qxmd.com)
  • The arrangement of atrial myocytes was disordered and the collagen volume fraction of the atrium tissue was elevated in the DM group compared with the control group , and improved by allopurinol . (bvsalud.org)
  • Atrial fibrillation (AF) is a highly prevalent condition associated with pronounced morbidity, mortality, and socioeconomic burden, accounting for more hospitalization days than any other arrhythmias. (ahajournals.org)
  • Patients with permanent pacemakers have a high risk of atrial fibrillation (AF), particularly those with hypertension, sinus node dysfunction, and those with short episodes of atrial arrhythmias, known as atrial high-rate episodes (AHRE). (clinicaltrials.gov)
  • It may be prudent to abort both types of arrhythmias early to prevent electrical remodeling. (onlinejacc.org)
  • Five of six patients experienced resolution of their preclosure arrhythmias, whereas the remaining patient continued to have paroxysmal atrial fibrillation. (erciyes.edu.tr)
  • Cine-CMR quantified LA diameter provides a simple measure of atrial remodeling that correlates well with LA area, yielding similar predictive value for stratifying MR as well as longitudinal risk for atrial arrhythmias. (biomedcentral.com)
  • Post-operative atrial arrhythmias seem to be related to the degree of inflammation and oxidative stress induced during surgery. (bioportfolio.com)
  • 2-4) Our group and others have shown that atrial arrhythmias are associated with increased oxidative stress. (bioportfolio.com)
  • OBJECTIVE: Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling, contributing to the progressive nature of the arrhythmia. (biomedsearch.com)
  • Although a number of markers have been reported as potential predictors of paroxysmal atrial fibrillation progression towards persistent arrhythmia, their usefulness and clinical value need further validation. (scirp.org)
  • Pharmacological therapy for atrial fibrillation in the heart failure population remains limited due to sub-optimal drug efficacy and a likely increased mortality due to pro-arrhythmia. (scirp.org)
  • Atrial fibrillation (AF) is the most common arrhythmia affecting patients after general thoracic surgery. (frontiersin.org)
  • Atrial fibrillation (AF) is a common arrhythmia which is associated with higher risk of stroke , heart failure and all-cause mortality . (bvsalud.org)
  • Atrial fibrillation is the most common arrhythmia in patients visiting a primary care practice. (aafp.org)
  • Persistent atrial fibrillation is defined by persistence of the arrhythmia until cardioversion is performed. (aafp.org)
  • Atrial fibrillation is a complex arrhythmia and its precise mechanisms remain unclear. (fda.gov)
  • We know that AF is a progressive disease that most patients go from paroxysmal to persistent, and then to permanent atrial fibrillation," he began. (afsymposium.com)
  • age: 57±10years) with paroxysmal or non-paroxysmal atrial fibrillation were studied serially using CMR at baseline and at 1-, 3-, 6- and 12-month intervals following PVI. (uzh.ch)
  • This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. (elsevier.com)
  • Paroxysmal atrial fibrillation is defined as recurrent episodes of spontaneously terminating atrial fibrillation. (aafp.org)
  • however, little is known about how they affect atrial pathophysiology or electrophysiology. (ahajournals.org)
  • It is important to determine which Ang II formation pathway (ACE or chymase) is more closely related to atrial electrophysiology. (ahajournals.org)
  • 1 - 5 A characteristic of both clinical and experimental AF is the alteration of electrophysiology that promotes persistent AF even in the absence of progressive underlying heart disease, so-called atrial remodeling or "AF begets AF. (ahajournals.org)
  • It is hypothesized that persistent atrial fibrillation-induced electrical remodeling (AFER) on atrial electrophysiology may be responsible for such impaired atrial mechanics. (bris.ac.uk)
  • The aim of this work is to integrate the effects of dronedarone into a model of atrial electrophysiology. (kit.edu)
  • Until the results of several large-scale randomized clinical trials are available, the decision to choose cardioversion or maintenance of sinus rhythm must be individualized, based on relief of symptoms and reduction of the morbidity and mortality associated with atrial fibrillation. (aafp.org)
  • ABSTRACT: Atrial fibrillation and heart failure often coexist in patients with advanced heart failure symptoms. (scirp.org)
  • abstract = "AIMS: Atrial stunning, a loss of atrial mechanical contraction, can occur following a successful cardioversion. (bris.ac.uk)
  • abstract = "Background: Atrial Fibrillation (AF) is the most common progressive tachyarrhythmia. (vumc.nl)
  • However, the pathophysiological role of tissue Ang II in atrial electrical remodeling has not been investigated. (ahajournals.org)
  • Methods and Results: Primary ECs were isolated from porcine atrial tissue. (mdpi.com)
  • Enhanced expression levels of vascular cell adhesion molecule (VCAM)-1, tissue factor, transforming growth factor (TGF)-β and MMP-2 and 9 characterized the senescence-associated secretory phenotype of atrial ECs. (mdpi.com)
  • Conclusions: Thrombin promotes premature ageing and senescence of atrial ECs and may pave the way to deleterious remodeling of atrial tissue by a local up-regulation of the angiotensin system and by promoting pro-inflammatory, pro-thrombotic, pro-fibrotic and pro-remodeling responses. (mdpi.com)
  • Experimental studies in goats and isolated human atrial tissue have shown that prolonged AF leads to persistent shortening of atrial refractoriness, a phenomenon referred to as electrical remodeling and which helps to explain why AF begets AF. (onlinejacc.org)
  • and (iii) AFER-AF condition for AF-remodeled tissue with re-entrant excitation waves (state 4). (bris.ac.uk)
  • We demonstrate that WNT-974 can improve the recovery of heart function after left anterior descending coronary artery ligation by mitigating adverse remodeling of infarcted tissue. (nih.gov)
  • The effects of pioglitazone on AngII-induced connective tissue growth factor (CTGF) expression and cell proliferation were assessed in primary-cultured mouse atrial fibroblasts. (qxmd.com)
  • miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. (pmarchive.ru)
  • maintaining the tissue growth member in the left atrial appendage with a locking element, the locking element including multiple fingers that collapse directly dependent upon proximally moving the threaded pusher member relative to the tissue growth member. (google.es)
  • 7. The method according to claim 6 , wherein pushing the tissue growth member over the tether further comprises positioning the catheter within the left atrial appendage and deploying the tissue growth member from the catheter while slidably coupled with the tether. (google.es)
  • In the course of chronic AF (cAF), electrical remodeling modifies the properties of the affected atrial tissue. (kit.edu)
  • Finally, a comparison of both agents and their impact on healthy and electrically remodeled tissue shall be carried out. (kit.edu)
  • Recent data show that TCs are completely different from FBs, using a quantitative proteomics approach, suggesting that TCs might play specific roles in mechanical sensing and mechanochemical conversion task, tissue homoeostasis and remodelling/renewal. (wikipedia.org)
  • If an individual has a few risk factors, the incidence of persistent atrial fibrillation is much lower than if you have a greater number of risk factors, in which case it is more likely that these individuals will progress to persistent atrial fibrillation. (afsymposium.com)
  • Effects of persistent atrial fibrillation on serum galectin-3 levels. (semanticscholar.org)
  • Thus, cardioversion is used only in cases of acute and chronic persistent atrial fibrillation and not in cases previously demonstrated to be refractory. (aafp.org)
  • Using monophasic action potential recordings at two right atrial sites simultaneously, we determined in 7 patients with chronic AF and 13 with chronic atrial flutter (3 weeks to 3 years in duration) the relation between paced cycle length and APD at 90% repolarization (APD90) 15 to 30 min after conversion to sinus rhythm. (onlinejacc.org)
  • There were no significant differences between patients with cardioversion from atrial flutter and those with cardioversion from AF. (onlinejacc.org)
  • APD90 at a steady state cycle length of 600 ms showed no significant correlation with the duration of previous AF or atrial flutter. (onlinejacc.org)
  • AF and atrial flutter lead to marked, quantitatively similar decreases in the right atrial APD during steady state pacing and extrastimulation a considerable time after cardioversion. (onlinejacc.org)
  • These data confirm that both AF and atrial flutter lead to electrical remodeling in the human atrium, with a preponderance at longer cycle lengths. (onlinejacc.org)
  • Clinical follow-up was performed via medical record review, with atrial fibrillation (AF) or flutter (AFl) verified based on physician documentation. (biomedcentral.com)
  • Background: Epicardial adiposity and plasma levels of free fatty acids (FFAs) are elevated in atrial fibrillation, heart failure and obesity, with potentially detrimental effects on myocardial function. (umn.edu)
  • Here, the factors contributing to the diverse properties and functional roles of myocardial K + channels are reviewed, and the molecular mechanisms contributing to the physiological regulation and pathological remodeling of myocardial K + channels are discussed. (pubmedcentralcanada.ca)
  • The review presents modern data on different molecules of microRNA involved in the regulation of myocardial remodeling processes in atrial fibrillation. (pmarchive.ru)
  • atrial fibrillation, microRNA, myocardial remodeling. (pmarchive.ru)
  • A common scenario for remodeling is after myocardial infarction. (wikipedia.org)
  • Impact of biomarkers of inflammation and extracellular matrix turnover on the outcome of atrial fibrillation ablation: importance of matrix metalloproteinase-2 as a predictor of atrial fibrillation recurrence. (semanticscholar.org)
  • Conclusions: Larger LAA volume predicts recurrence after ablation of AF in patients with enlarged LA. These finding suggests that LAA is an important substrate of AF in remodeled LA. (elsevier.com)
  • Arakelyan M.S., Poteshkina N.G., Mogutova P.A. Modern view on the problem of atrial fibrillation and its recurrence. (pmarchive.ru)
  • The surface ECG lead II, intracardiac electrograms, right atrial pressure, and blood pressure were continuously monitored and recorded at a paper speed of 100 mm/s (San Ei 8 MI4). (ahajournals.org)
  • A pacing lead introduced into the femoral vein was placed in the right atrial appendage to measure the AERP. (ahajournals.org)
  • To minimize confounding effects caused by electrode polarization, all refractory period measurements were made with the pacing lead, which was not used for high-frequency pacing and was positively affixed to the right atrial appendage. (ahajournals.org)
  • Methods and Results- The miRNA transcriptome was analyzed by microarray and verified by real-time reverse-transcription polymerase chain reaction with left atrial samples from dogs with AF established by right atrial tachypacing for 8 weeks and from human atrial samples from AF patients with rheumatic heart disease. (ahajournals.org)
  • Table 1 shows correlations between high scar score and right atrial enlargement, but no other analyzed variables. (biomedcentral.com)
  • This review focuses on atrial fibrillation ablation in patients with congestive heart failure, and summarizes the results of available literature. (scirp.org)
  • Congestive heart failure (CHF) predisposes to atrial fibrillation (AF), although the underlying mechanisms remain incompletely understood. (ahajournals.org)
  • METHODS AND RESULTS: A 3D electromechanical model of the human atria was developed to investigate the effects of AFER on atrial electro-mechanics. (bris.ac.uk)
  • Hypoxic stress upsets the balance in the normal relationships between mitogenic and growth inhibiting pathways in lung, resulting in pulmonary vascular remodeling characterized by hyperplasia of pulmonary arterial smooth muscle cells (PASMCs) and fibroblasts and enhanced deposition of extracellular matrix. (ovid.com)
  • BACKGROUND Galectin-3 (Gal-3) mediates extracellular matrix remodeling in heart failure, but its role in AF progression remains unexplored. (semanticscholar.org)
  • Aortic stenosis results in increased filling pressures with progressive left atrial enlargement and dysfunction. (bmj.com)
  • Atrial biopsies from AF patients display mitochondrial dysfunction, evidenced by aberrant ATP levels, upregulation of a mitochondrial stress chaperone and fragmentation of the mitochondrial network. (eur.nl)
  • The pathophysiological role of mitochondrial dysfunction is substantiated by the attenuation of AF remodeling by preventing an increased mitochondrial Ca2+-influx through partial blocking or downregulation of the mitochondrial calcium uniporter, and by SS31, a compound that improves bioenergetics in mitochondria. (eur.nl)
  • Atrial fibrillation inducibility and duration were higher and longer only in the LVH group (P = 0.002, 0.079, respectively), and isolated LV diastolic dysfunction and elevated LV pressure were observed. (elsevier.com)
  • Voltage maps of the atria demonstrated large areas of low voltage, increased areas of scarring and a more complex electrogram in a patient with heart failure, when compared to control… This has become what is a common feature for the substrate of atrial fibrillation. (afsymposium.com)
  • These results indicate for the first time that Ang II may be involved in the mechanism of atrial electrical remodeling and that the blockade of Ang II may lead to the better therapeutic management of human atrial fibrillation. (ahajournals.org)
  • CONCLUSIONS: These data indicate that the electrical remodeling that occurs after cardioversion is at least partially mediated by changes in KATP channel behavior. (doaj.org)
  • Conclusions- miR-328 contributes to the adverse atrial electric remodeling in AF through targeting L-type Ca 2+ channel genes. (ahajournals.org)
  • Conclusions- Left atrial dilatation in the population is more common in black and Hispanic than in white individuals and is associated with parallel changes in the LV. (ovid.com)
  • Conclusions and Implications: Clinically, we tested whether anthracycline-induced early atrial remodeling in patients could be detected by echocardiography. (authorea.com)
  • CONCLUSIONS: This study provides novel insights into understanding atrial electro-mechanics illustrating that AFER impairs atrial contraction due to reduced intracellular Ca2+ transients. (bris.ac.uk)
  • Conclusions: CHF upregulates fibroblast KCNJ2 expression and currents, thereby hyperpolarizing RMP, increasing Ca 2+ entry, and enhancing atrial fibroblast proliferation. (fujita-hu.ac.jp)
  • CONCLUSIONS: CV dynamics are determined largely by the extent of remodeling. (ucl.ac.uk)
  • Conclusions: In patients with symptomatic severe aortic valve stenosis undergoing aortic valve replacement, left atrial volume provides important prognostic information beyond standard risk factors. (elsevier.com)
  • In addition, the effects of thrombin on atrial fibroblasts and remodeling are studied. (rug.nl)
  • METHODS: Cultured canine atrial fibroblasts were treated with medium from rapidly-paced atrial cardiomyocytes, non-paced cardiomyocytes and cardiomyocyte-pacing medium only, and analyzed by [(3)H]thymidine incorporation, Western blot and real-time RT-PCR. (biomedsearch.com)
  • Pioglitazone attenuated AngII-induced CTGF expression and proliferation in atrial fibroblasts, and pioglitazone also inhibited the expression or phosphorylation of AngII-induced transforming growth factor-β1 (TGF-β1), tumor necrosis factor receptor associated factor 6 (TRAF6), TGF-β-associated kinase 1 (TAK1) and Smad2/3. (qxmd.com)
  • Besides, pioglitazone inhibited AngII-induced production of AngII type I receptor (AT1R) and downregulation of PPAR-γ in both atrial fibroblasts and HL-1 cells. (qxmd.com)
  • In conclusion, Pioglitazone suppresses AngII-induced CTGF expression and proliferation in atrial fibroblasts, which might be at least in part related with its inhibitory effects on TGF-β1/Smad2/3 and TGF-β1/TRAF6/TAK1 signaling pathways. (qxmd.com)
  • Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts. (qxmd.com)
  • Pioglitazone inhibits angiotensin II-induced atrial fibroblasts proliferation via NF-κB/TGF-β1/TRIF/TRAF6 pathway. (qxmd.com)
  • Atrial natriuretic peptide (ANP) reduces pulmonary vascular resistance and attenuates hypoxia-induced pulmonary hypertension in vivo and PASMC proliferation and collagen synthesis in vitro. (ovid.com)
  • Previous studies in a hypertensive animal model of stroke and in humans showed that mutations of the atrial natriuretic peptide (ANP) gene are associated with increased risk of stroke. (mdc-berlin.de)
  • However, atrial natriuretic peptide is thought to be cardio-protective. (wikipedia.org)
  • Hoit BD, Shao Y, Gabel M. Left atrial systolic and diastolic function accompanying chronic rapid pacing-induced atrial failure. (springer.com)
  • patients with subsequent relapse of atrial fibrillation, however, exhibited no significant change of LA diastolic and systolic volumes or LA ejection fraction. (uzh.ch)
  • CONCLUSION: Restoration of sinus rhythm led to a significant and progressive decrease of left-atrial diastolic and systolic volumes during one year following pulmonary vein isolation. (uzh.ch)
  • These multiple aberrantly expressed microRNAs may be responsible for modulating the transition from adaptation to pathological atrial remodeling with aging and/or in AF. (bvsalud.org)
  • This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling). (wikipedia.org)
  • Physiological remodeling is reversible while pathological remodeling is mostly irreversible. (wikipedia.org)
  • 7 8 9 10 This phenomenon of electrical remodeling increases the inducibility and stability of atrial fibrillation. (ahajournals.org)
  • Atrial tachypacing for 30 minutes increased AF inducibility and decreased AF cycle length. (ahajournals.org)
  • AF-induced atrial electrical remodeling, AF inducibility, and AF cycle length were not modified, but duration of AF episodes was shorter after RDN. (ahajournals.org)
  • In addition, there is a greater inducibility of atrial fibrillation. (afsymposium.com)
  • Mice were injected with doxorubicin or vehicle and the following parameters were determined: left atrial diameter, electrical transmission, AF inducibility. (authorea.com)
  • Atrial remodeling and AF inducibility were induced after doxorubicin injection, which can be inhibited by dexrazoxane. (authorea.com)
  • At 12 weeks after operation, atrial fibrillation (AF) inducibility and duration were assessed by in vivo burst transoesophageal pacing. (elsevier.com)
  • Pathologic pressure mismatches between the pulmonary and systemic circulation guide compensatory remodeling of the left and right ventricles. (wikipedia.org)
  • Background: Atrial electrical remodeling (AER) is one of the mechanisms by which atrial fibrillation (AF) begets AF. (elsevier.com)
  • At the molecular level, angiotensin II, transforming growth factor-β1, inflammation and oxidative stress are particularly important for ECM dysregulation and atrial fibrotic remodeling in AF. (elsevier.com)
  • These data indicate xanthine oxidase inhibition can reduce oxidative stress and ameliorate atrial electrical remodeling . (bvsalud.org)
  • Our group and others have shown that atrial abnormal heart beats are associated with increased oxidative stress. (bioportfolio.com)
  • Methods Before and 6 months after RDN, BP, HR, LV mass, left atrial volume index (LAVI), diastolic function (echocardiography), and premature atrial contractions (PAC) (Holter electrocardiogram) were assessed in 66 patients with resistant hypertension. (onlinejacc.org)
  • however, the effect on diastolic function and left atrial (LA) remodeling is unclear. (elsevier.com)
  • The same pacing protocols and measurements were performed in nine control patients with sinus rhythm and no overt atrial disease. (onlinejacc.org)
  • Unipolar electrograms were recorded with a 64-pole basket catheter during atrial pacing at four pacing intervals (PIs) during sinus rhythm. (ucl.ac.uk)
  • Although many patients with atrial fibrillation experience relief of symptoms with control of the heart rate, some patients require restoration of sinus rhythm. (aafp.org)
  • External direct current (DC) cardioversion is the most effective means of converting atrial fibrillation to sinus rhythm. (aafp.org)
  • 3 Atrial fibrillation also can decrease exercise tolerance and has been associated with tachycardia-induced cardiomyopathy. (aafp.org)
  • 9. Electrophysiological ablation for atrial tachycardia within 6 months of the operation. (bioportfolio.com)
  • Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. (springer.com)
  • Hence, targeting thrombin and/or angiotensin systems may efficiently prevent atrial endothelial senescence. (mdpi.com)
  • Several studies have shown that activation of the renin-angiotensin system is associated with the mechanism of atrial fibrillation (AF) (1-3) . (onlinejacc.org)
  • They also showed the down-regulation of atrial angiotensin II type 1 receptor (AT1R) and the up-regulation of AT2R in AF patients (2) . (onlinejacc.org)
  • RAAS hyperactivity may be attenuated pharmacologically with angiotensin II receptor blockers (ARB) which in systemic hypertension with LV hypertrophy has been associated with reverse remodelling. (clinicaltrials.gov)
  • The hypothesis is that in patients undergoing AVR for symptomatic AVS, 12 months post operative blockade of the angiotensin II receptor will accelerate LV and LA reverse remodelling, reduce filling pressures and suppress neurohormonal activation compared with conventional therapy. (clinicaltrials.gov)
  • It has been demonstrated that atrial remodeling contributes toward atrial fibrillation (AF) maintenance and angiotensin II (AngII) is involved in the pathogenesis of atrial remodeling. (qxmd.com)
  • Objective: One of the hemodynamic consequences of aortic valve stenosis is pressure overload leading to left atrial dilatation. (elsevier.com)
  • Therefore, in the present study, we examined the inhibitory effects of an AT 1 receptor antagonist, candesartan, or an ACEI, captopril, on the atrial electrical remodeling induced by rapid pacing in a dog model. (ahajournals.org)
  • Hypothesis: Different alterations of volume between left atrium (LA) and appendage (LAA) can predict clinical outcome of ablation of atrial fibrillation (AF). (elsevier.com)
  • The use of ablation in the treatment of atrial fibrillation has captured the greatest attention in journals and at national meetings, and it is a major focus of this book. (springer.com)
  • This guidance provides FDA's recommendations on clinical trial designs for surgical ablation devices intended for the treatment of atrial fibrillation (AF). (fda.gov)
  • The electrophysiologic mechanism for atrial fibrillation appears to be multiple wavelets of reentry. (aafp.org)
  • Notably, the roles of such markers in the pathophysiology of atrial fibrillation must be determined. (scirp.org)
  • Dobrev D. Is Altered Atrial microRNA-ome a Critical Contributor to Pathophysiology of Atrial Fibrillation? (kompetenznetz-vorhofflimmern.de)