Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
A series of actions, sometimes symbolic actions which may be associated with a behavior pattern, and are often indispensable to its performance.
The chambers of the heart, to which the BLOOD returns from the circulation.
Reflex contraction of a muscle in response to stretching, which stimulates muscle proprioceptors.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The act or practice of killing for reasons of mercy, i.e., in order to release a person or animal from incurable disease, intolerable suffering, or undignified death. (from Beauchamp and Walters, Contemporary Issues in Bioethics, 5th ed)
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Long-term maintenance hemodialysis in the home.
Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure.
'Water softening' is a water treatment process that reduces the hardness of water by removing calcium, magnesium, and certain other metal cations (such as iron and manganese) through the use of ion-exchange resins or other methods like nanofiltration or reverse osmosis.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Portable peritoneal dialysis using the continuous (24 hours a day, 7 days a week) presence of peritoneal dialysis solution in the peritoneal cavity except for periods of drainage and instillation of fresh solution.
Facilities which provide nursing supervision and limited medical care to persons who do not require hospitalization.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The hollow, muscular organ that maintains the circulation of the blood.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).

Pre-procedural prediction of termination of persistent atrial fibrillation by catheter ablation as an indicator of reverse remodeling of the left atrium. (1/11)

BACKGROUND: The pre-procedural prediction of atrial fibrillation (AF) termination by catheter ablation in patients with persistent AF has not been evaluated fully. The aim of this study was to evaluate the pre-procedural predictors of persistent AF termination by ablation associated with the possibility of reverse remodeling of the left atrium (LA). METHODS AND RESULTS: Seventy consecutive patients (mean age, 62+/-8 years) with persistent or long-standing persistent AF underwent ablation. They were divided into 2 groups: those with AF terminated by ablation (n=14; group 1) and those with AF terminated by cardioversion after ablation (n=56; group 2). The left atrial appendage (LAA) contraction velocity determined on transesophageal echocardiography was significantly decreased in group 2 as compared to group 1 (P<0.001). Kaplan-Meier analysis showed that the group 1 patients had a higher AF-free survival rate than those in group 2 during 12+/-4.1 months of follow-up (P=0.048). The LA reverse remodeling ratio, given as the volume difference between before and 3 months after ablation in group 1, was significantly greater after ablation than that in group 2 (25.8+/-13% vs. 15.0+/-15%, P=0.015). Multivariate logistic regression analysis indicated that the LAA contraction velocity was an independent predictor of persistent AF termination by ablation (P=0.018). CONCLUSIONS: The LAA contraction velocity was the only non-invasive pre-procedural predictor of persistent AF termination by ablation, indicating the possibility of reverse remodeling of the LA.  (+info)

Changes in microRNAs expression are involved in age-related atrial structural remodeling and atrial fibrillation. (2/11)

BACKGROUND: Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been implicated in the aging process and in the regulation of extracellular matrix proteins. However, their role in age-related cardiac remodeling and atrial fibrillation (AF) was not well understood. The present study was designed to decipher molecular mechanisms underlying age-related atrial structural remodeling and AF. METHODS: Three groups of dogs were studied: adult and aged dogs in sinus rhythm and with persistent AF induced by rapid atrial pacing. The expressions of microRNAs were measured by quantitative real-time polymerase chain reaction. Pathohistological and ultrastructural changes were tested by light and electron microscopy. Apoptosis index of myocytes was detected by TUNEL. RESULTS: Samples of atrial tissue showed the abnormal pathohistological and ultrastructural changes, the accelerated fibrosis, and apoptosis with aging and/or in AF dogs. Compared to the adult group, the expressions of microRNAs-21 and -29 were significantly increased, whereas the expressions of microRNAs-1 and -133 showed obvious downregulation tendency in the aged group. Compared to the aged group, the expressions of microRNAs-1, -21, and -29 was significantly increased in the old group in AF; contrastingly, the expressions of microRNA-133 showed obvious downregulation tendency. CONCLUSION: These multiple aberrantly expressed microRNAs may be responsible for modulating the transition from adaptation to pathological atrial remodeling with aging and/or in AF.  (+info)

An Angiotensin receptor blocker prevents arrhythmogenic left atrial remodeling in a rat post myocardial infarction induced heart failure model. (3/11)


Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing. (4/11)


MicroRNAs in pulmonary arterial remodeling. (5/11)


Left atrial endocardial fibrosis and intra-atrial thrombosis - landmarks of left atrial remodeling in rats with spontaneous atrial tachyarrhythmias. (6/11)

INTRODUCTION: Histological abnormalities are common findings in the left atria (LA) of atrial fibrillation (AF) patients. We aimed to assess LA histological abnormalities in our model of spontaneous atrial tachyarrhythmias in rats. MATERIALS AND METHODS: LA sampling was performed in 12 spontaneously hypertensive rats (SHRs) and eight age-matched Wistar-Kyoto (WKY) rats. Tissue sections were stained with Masson's trichrome and Hematoxylin-Eosin-Safran and examined with a light microscope. A 0 to 3 scoring system was used to quantify the severity of LA structural abnormalities. LA von Willebrand factor (vWF) content was also assessed using immunohistochemical staining. RESULTS: In six of the eight SHRs, LA fibrosis, inflammatory infiltrates, and myocyte necrosis of varying grades of severity were observed. The most frequent feature was endocardial fibrosis, which was observed in six SHRs and in none of the WKY rats. Intra-atrial thrombosis was found in three SHRs and in none of the WKY rats. The intensity of vWF-related fluorescence was higher in the atrial endocardium of SHRs compared to age-matched WKY rats. CONCLUSIONS: Our findings reinforce the role of LA structural abnormalities in atrial arrhythmogenicity. However, two SHRs did not present LA histological abnormalities despite the presence of arrhythmias. This finding suggests that the LA remodeling-atrial tachyarrhythmia relationship could be highly nonlinear and that atrial fibrosis is more likely to be a facilitator of atrial arrhythmogenicity, rather than a prerequisite. We also provide evidence that intra-atrial thrombosis accompanies LA structural remodeling in arrhythmic rats. Increased endocardial platelet adhesion molecule vWF could contribute to this increased thrombogenicity.  (+info)

Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation. (7/11)


Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing. (8/11)


Atrial fibrillation (A-tre-al fi-bru-la'shun) is a type of abnormal heart rhythm characterized by rapid and irregular beating of the atria, the upper chambers of the heart. In this condition, the electrical signals that coordinate heartbeats don't function properly, causing the atria to quiver instead of contracting effectively. As a result, blood may not be pumped efficiently into the ventricles, which can lead to blood clots, stroke, and other complications. Atrial fibrillation is a common type of arrhythmia and can cause symptoms such as palpitations, shortness of breath, fatigue, and dizziness. It can be caused by various factors, including heart disease, high blood pressure, age, and genetics. Treatment options include medications, electrical cardioversion, and surgical procedures to restore normal heart rhythm.

I'm not aware of a specific medical definition for "ceremonial behavior." However, in general, ceremonial behaviors are actions or rituals that are performed in a formal, ritualistic manner, often as part of a cultural, religious, or social tradition. These behaviors can serve various purposes, such as marking important life events, expressing shared values and beliefs, or reinforcing social bonds.

In some cases, ceremonial behaviors may have health implications. For example, participation in cultural or religious rituals can provide a sense of community and support, which can have positive effects on mental health. Additionally, certain ceremonial practices, such as meditation or prayer, may have direct physiological effects that contribute to stress reduction and relaxation.

However, it's important to note that the term "ceremonial behavior" is not a medical diagnosis or clinical concept, and its meaning can vary depending on the context in which it is used.

The heart atria are the upper chambers of the heart that receive blood from the veins and deliver it to the lower chambers, or ventricles. There are two atria in the heart: the right atrium receives oxygen-poor blood from the body and pumps it into the right ventricle, which then sends it to the lungs to be oxygenated; and the left atrium receives oxygen-rich blood from the lungs and pumps it into the left ventricle, which then sends it out to the rest of the body. The atria contract before the ventricles during each heartbeat, helping to fill the ventricles with blood and prepare them for contraction.

A stretch reflex, also known as myotatic reflex, is a rapid muscle contraction in response to stretching within the muscle itself. It is a type of reflex that helps to maintain muscle tone, protect muscles and tendons from injury, and assists in coordinating movements.

The stretch reflex is mediated by the stretch (or length) receptors called muscle spindles, which are located within the muscle fibers. When a muscle is stretched suddenly or rapidly, the muscle spindles detect the change in muscle length and activate a rapid motor neuron response, leading to muscle contraction. This reflex helps to stabilize the joint and prevent further stretching or injury.

The most common example of a stretch reflex is the knee-jerk reflex (also known as the patellar reflex), which is elicited by tapping the patellar tendon just below the knee, causing the quadriceps muscle to stretch and contract. This results in a quick extension of the lower leg. Other examples of stretch reflexes include the ankle jerk reflex (Achilles reflex) and the biceps reflex.

Heart failure is a pathophysiological state in which the heart is unable to pump sufficient blood to meet the metabolic demands of the body or do so only at the expense of elevated filling pressures. It can be caused by various cardiac disorders, including coronary artery disease, hypertension, valvular heart disease, cardiomyopathy, and arrhythmias. Symptoms may include shortness of breath, fatigue, and fluid retention. Heart failure is often classified based on the ejection fraction (EF), which is the percentage of blood that is pumped out of the left ventricle during each contraction. A reduced EF (less than 40%) is indicative of heart failure with reduced ejection fraction (HFrEF), while a preserved EF (greater than or equal to 50%) is indicative of heart failure with preserved ejection fraction (HFpEF). There is also a category of heart failure with mid-range ejection fraction (HFmrEF) for those with an EF between 40-49%.

Active euthanasia is the deliberate act of causing the death of a patient, at their voluntary and competent request, in order to relieve them from suffering from an incurable illness or condition. It is also known as physician-assisted suicide or doctor-assisted dying. This practice is regulated and legal in some countries, such as the Netherlands, Belgium, and Canada, under strict conditions and regulations. In contrast, passive euthanasia refers to the withholding or withdrawing of life-sustaining treatments, allowing the natural course of the disease to take its place, which is generally more accepted and less controversial than active euthanasia.

Cardiac arrhythmias are abnormal heart rhythms that result from disturbances in the electrical conduction system of the heart. The heart's normal rhythm is controlled by an electrical signal that originates in the sinoatrial (SA) node, located in the right atrium. This signal travels through the atrioventricular (AV) node and into the ventricles, causing them to contract and pump blood throughout the body.

An arrhythmia occurs when there is a disruption in this electrical pathway or when the heart's natural pacemaker produces an abnormal rhythm. This can cause the heart to beat too fast (tachycardia), too slow (bradycardia), or irregularly.

There are several types of cardiac arrhythmias, including:

1. Atrial fibrillation: A rapid and irregular heartbeat that starts in the atria (the upper chambers of the heart).
2. Atrial flutter: A rapid but regular heartbeat that starts in the atria.
3. Supraventricular tachycardia (SVT): A rapid heartbeat that starts above the ventricles, usually in the atria or AV node.
4. Ventricular tachycardia: A rapid and potentially life-threatening heart rhythm that originates in the ventricles.
5. Ventricular fibrillation: A chaotic and disorganized electrical activity in the ventricles, which can be fatal if not treated immediately.
6. Heart block: A delay or interruption in the conduction of electrical signals from the atria to the ventricles.

Cardiac arrhythmias can cause various symptoms, such as palpitations, dizziness, shortness of breath, chest pain, and fatigue. In some cases, they may not cause any symptoms and go unnoticed. However, if left untreated, certain types of arrhythmias can lead to serious complications, including stroke, heart failure, or even sudden cardiac death.

Treatment for cardiac arrhythmias depends on the type, severity, and underlying causes. Options may include lifestyle changes, medications, cardioversion (electrical shock therapy), catheter ablation, implantable devices such as pacemakers or defibrillators, and surgery. It is essential to consult a healthcare professional for proper evaluation and management of cardiac arrhythmias.

Home hemodialysis is a type of renal replacement therapy that can be performed at the patient's residence. It involves the use of a home hemodialysis machine, which pumps the patient's blood through a dialyzer to remove waste products and excess fluids. The cleaned blood is then returned back to the patient's body.

In home hemodialysis, patients or their caregivers are trained to perform the procedure themselves, typically with the help of a healthcare professional who visits their home. This allows for greater flexibility in scheduling treatments, which can be done more frequently (e.g., five to six times per week) and for longer durations than traditional in-center hemodialysis.

Home hemodialysis has been shown to have several potential benefits over in-center hemodialysis, including improved blood pressure control, better phosphate management, reduced need for medication, and potentially slower progression of kidney disease. However, it also requires a significant commitment from the patient or caregiver, as well as investment in home modifications and equipment.

Peritoneal dialysis is a type of renal replacement therapy used to treat patients with severe kidney dysfunction or end-stage renal disease. It is a process that utilizes the peritoneum, a membranous sac lining the abdominal cavity, as a natural semipermeable membrane for filtering waste products, excess fluids, and electrolytes from the bloodstream.

In peritoneal dialysis, a sterile dialysate solution is infused into the peritoneal cavity via a permanently implanted catheter. The dialysate contains various substances such as glucose or other osmotic agents, electrolytes, and buffer solutions that facilitate the diffusion of waste products and fluids from the blood vessels surrounding the peritoneum into the dialysate.

There are two primary types of peritoneal dialysis: continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD). CAPD is performed manually, several times a day, while APD is carried out using a cycler machine overnight.

Peritoneal dialysis offers certain advantages over hemodialysis, such as better preservation of residual renal function, fewer dietary restrictions, and greater flexibility in scheduling treatments. However, it also has potential complications, including peritonitis (inflammation of the peritoneum), catheter-related infections, fluid imbalances, and membrane failure over time.

Water softening is not a medical term, but rather a process used in water treatment. It refers to the removal of minerals such as calcium, magnesium, and certain iron compounds that make water "hard." These minerals can cause scaling and other problems when water is heated or used in appliances and plumbing systems.

In a medical context, softened water may have implications for skin health, as hard water can leave deposits on the skin that can lead to dryness and irritation. However, there is no specific medical definition associated with 'water softening.'

Renal dialysis is a medical procedure that is used to artificially remove waste products, toxins, and excess fluids from the blood when the kidneys are no longer able to perform these functions effectively. This process is also known as hemodialysis.

During renal dialysis, the patient's blood is circulated through a special machine called a dialyzer or an artificial kidney, which contains a semi-permeable membrane that filters out waste products and excess fluids from the blood. The cleaned blood is then returned to the patient's body.

Renal dialysis is typically recommended for patients with advanced kidney disease or kidney failure, such as those with end-stage renal disease (ESRD). It is a life-sustaining treatment that helps to maintain the balance of fluids and electrolytes in the body, prevent the buildup of waste products and toxins, and control blood pressure.

There are two main types of renal dialysis: hemodialysis and peritoneal dialysis. Hemodialysis is the most common type and involves using a dialyzer to filter the blood outside the body. Peritoneal dialysis, on the other hand, involves placing a catheter in the abdomen and using the lining of the abdomen (peritoneum) as a natural filter to remove waste products and excess fluids from the body.

Overall, renal dialysis is an essential treatment option for patients with kidney failure, helping them to maintain their quality of life and prolong their survival.

Chronic kidney failure, also known as chronic kidney disease (CKD) stage 5 or end-stage renal disease (ESRD), is a permanent loss of kidney function that occurs gradually over a period of months to years. It is defined as a glomerular filtration rate (GFR) of less than 15 ml/min, which means the kidneys are filtering waste and excess fluids at less than 15% of their normal capacity.

CKD can be caused by various underlying conditions such as diabetes, hypertension, glomerulonephritis, polycystic kidney disease, and recurrent kidney infections. Over time, the damage to the kidneys can lead to a buildup of waste products and fluids in the body, which can cause a range of symptoms including fatigue, weakness, shortness of breath, nausea, vomiting, and confusion.

Treatment for chronic kidney failure typically involves managing the underlying condition, making lifestyle changes such as following a healthy diet, and receiving supportive care such as dialysis or a kidney transplant to replace lost kidney function.

Peritoneal dialysis, continuous ambulatory (CAPD), is a type of renal replacement therapy used to treat patients with end-stage kidney disease. It is a form of peritoneal dialysis that is performed continuously, without the need for machines or hospitalization. CAPD uses the patient's own peritoneum, a thin membrane that lines the abdominal cavity, as a natural filter to remove waste products and excess fluids from the bloodstream.

In CAPD, a sterile dialysis solution is introduced into the peritoneal cavity through a permanent catheter implanted in the patient's abdomen. The solution remains in the peritoneal cavity for a dwell time of several hours, during which diffusion occurs across the peritoneal membrane, allowing waste products and excess fluids to move from the bloodstream into the dialysis solution.

After the dwell time, the used dialysis solution is drained from the peritoneal cavity and discarded, and a fresh batch of dialysis solution is introduced. This process is typically repeated four to five times a day, with each exchange taking about 30 minutes to complete. Patients can perform CAPD exchanges while going about their daily activities, making it a convenient and flexible treatment option for many patients with end-stage kidney disease.

Overall, CAPD is a highly effective form of dialysis that offers several advantages over other types of renal replacement therapy, including improved quality of life, better preservation of residual kidney function, and lower costs. However, it does require careful attention to sterile technique and regular monitoring to ensure proper functioning of the peritoneal membrane and adequate clearance of waste products and fluids.

A nursing home, also known as a skilled nursing facility, is a type of residential healthcare facility that provides round-the-clock care and assistance to individuals who require a high level of medical care and support with activities of daily living. Nursing homes are designed for people who cannot be cared for at home or in an assisted living facility due to their complex medical needs, mobility limitations, or cognitive impairments.

Nursing homes provide a range of services, including:

1. Skilled nursing care: Registered nurses and licensed practical nurses provide 24-hour medical care and monitoring for residents with chronic illnesses, disabilities, or those recovering from surgery or illness.
2. Rehabilitation services: Physical, occupational, and speech therapists help residents regain strength, mobility, and communication skills after an injury, illness, or surgery.
3. Personal care: Certified nursing assistants (CNAs) help residents with activities of daily living, such as bathing, dressing, grooming, and using the bathroom.
4. Meals and nutrition: Nursing homes provide three meals a day, plus snacks, and accommodate special dietary needs.
5. Social activities: Recreational programs and social events are organized to help residents stay active and engaged with their peers.
6. Hospice care: Some nursing homes offer end-of-life care for residents who require palliative or comfort measures.
7. Secure environments: For residents with memory impairments, specialized units called memory care or Alzheimer's units provide a secure and structured environment to help maintain their safety and well-being.

When selecting a nursing home, it is essential to consider factors such as the quality of care, staff-to-resident ratio, cleanliness, and overall atmosphere to ensure the best possible experience for the resident.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Myocardial infarction (MI), also known as a heart attack, is a medical condition characterized by the death of a segment of heart muscle (myocardium) due to the interruption of its blood supply. This interruption is most commonly caused by the blockage of a coronary artery by a blood clot formed on the top of an atherosclerotic plaque, which is a buildup of cholesterol and other substances in the inner lining of the artery.

The lack of oxygen and nutrients supply to the heart muscle tissue results in damage or death of the cardiac cells, causing the affected area to become necrotic. The extent and severity of the MI depend on the size of the affected area, the duration of the occlusion, and the presence of collateral circulation.

Symptoms of a myocardial infarction may include chest pain or discomfort, shortness of breath, nausea, lightheadedness, and sweating. Immediate medical attention is necessary to restore blood flow to the affected area and prevent further damage to the heart muscle. Treatment options for MI include medications, such as thrombolytics, antiplatelet agents, and pain relievers, as well as procedures such as percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG).

In medical terms, the heart is a muscular organ located in the thoracic cavity that functions as a pump to circulate blood throughout the body. It's responsible for delivering oxygen and nutrients to the tissues and removing carbon dioxide and other wastes. The human heart is divided into four chambers: two atria on the top and two ventricles on the bottom. The right side of the heart receives deoxygenated blood from the body and pumps it to the lungs, while the left side receives oxygenated blood from the lungs and pumps it out to the rest of the body. The heart's rhythmic contractions and relaxations are regulated by a complex electrical conduction system.

Congenital heart defects (CHDs) are structural abnormalities in the heart that are present at birth. They can affect any part of the heart's structure, including the walls of the heart, the valves inside the heart, and the major blood vessels that lead to and from the heart.

Congenital heart defects can range from mild to severe and can cause various symptoms depending on the type and severity of the defect. Some common symptoms of CHDs include cyanosis (a bluish tint to the skin, lips, and fingernails), shortness of breath, fatigue, poor feeding, and slow growth in infants and children.

There are many different types of congenital heart defects, including:

1. Septal defects: These are holes in the walls that separate the four chambers of the heart. The two most common septal defects are atrial septal defect (ASD) and ventricular septal defect (VSD).
2. Valve abnormalities: These include narrowed or leaky valves, which can affect blood flow through the heart.
3. Obstruction defects: These occur when blood flow is blocked or restricted due to narrowing or absence of a part of the heart's structure. Examples include pulmonary stenosis and coarctation of the aorta.
4. Cyanotic heart defects: These cause a lack of oxygen in the blood, leading to cyanosis. Examples include tetralogy of Fallot and transposition of the great arteries.

The causes of congenital heart defects are not fully understood, but genetic factors and environmental influences during pregnancy may play a role. Some CHDs can be detected before birth through prenatal testing, while others may not be diagnosed until after birth or later in childhood. Treatment for CHDs may include medication, surgery, or other interventions to improve blood flow and oxygenation of the body's tissues.

The myocardium is the middle layer of the heart wall, composed of specialized cardiac muscle cells that are responsible for pumping blood throughout the body. It forms the thickest part of the heart wall and is divided into two sections: the left ventricle, which pumps oxygenated blood to the rest of the body, and the right ventricle, which pumps deoxygenated blood to the lungs.

The myocardium contains several types of cells, including cardiac muscle fibers, connective tissue, nerves, and blood vessels. The muscle fibers are arranged in a highly organized pattern that allows them to contract in a coordinated manner, generating the force necessary to pump blood through the heart and circulatory system.

Damage to the myocardium can occur due to various factors such as ischemia (reduced blood flow), infection, inflammation, or genetic disorders. This damage can lead to several cardiac conditions, including heart failure, arrhythmias, and cardiomyopathy.

The heart ventricles are the two lower chambers of the heart that receive blood from the atria and pump it to the lungs or the rest of the body. The right ventricle pumps deoxygenated blood to the lungs, while the left ventricle pumps oxygenated blood to the rest of the body. Both ventricles have thick, muscular walls to generate the pressure necessary to pump blood through the circulatory system.

Heart valve diseases are a group of conditions that affect the function of one or more of the heart's four valves (tricuspid, pulmonic, mitral, and aortic). These valves are responsible for controlling the direction and flow of blood through the heart. Heart valve diseases can cause the valves to become narrowed (stenosis), leaky (regurgitation or insufficiency), or improperly closed (prolapse), leading to disrupted blood flow within the heart and potentially causing symptoms such as shortness of breath, fatigue, chest pain, and irregular heart rhythms. The causes of heart valve diseases can include congenital defects, age-related degenerative changes, infections, rheumatic heart disease, and high blood pressure. Treatment options may include medications, surgical repair or replacement of the affected valve(s), or transcatheter procedures.

However, atrial natriuretic peptide is thought to be cardio-protective. Remodeling of the heart is evaluated by performing an ... Physiological remodeling is reversible while pathological remodeling is mostly irreversible. Remodeling of the ventricles under ... In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of ... This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling ...
Mandache, E.; Gherghiceanu, M.; Macarie, C.; Kostin, S.; Popescu, L. M. (December 2010). "Telocytes in human isolated atrial ... tissue homoeostasis and remodelling/renewal. Figure 9. Human mammary gland stroma: TEM; original magnification 9,100x. A: ... amyloidosis: ultrastructural remodelling". Journal of Cellular and Molecular Medicine. 14 (12): 2739-2747. doi:10.1111/j.1582- ...
"Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling". The Journal of ... Ablation of sarcolipin increases atrial Ca2+ transient amplitudes and enhanced atrial contractility. Furthermore, atria from ... "Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility". Proceedings of the National ...
October 2012). "Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction ... November 2010). "Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice". The Journal of Clinical ...
ANP also acts in the heart to prevent cardiac hypertrophy and to regulate vascular remodeling and energy metabolism. NPPA ... Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac ... These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood ... ANP is secreted in response to: Stretching of the atrial wall, via Atrial volume receptors Increased Sympathetic stimulation of ...
The atrial remodeling that includes the pathologic changes described above has been referred to as atrial myopathy. There are ... which leads to atrial remodeling and fibrosis, with loss of atrial muscle mass. This process occurs gradually, and experimental ... left atrial volume, size, and left ventricular hypertrophy, characteristic of chronic hypertension. All atrial remodeling is ... This form of atrial fibrillation occurs in people of all ages but is most common in the elderly, in those with other atrial ...
... selectively increases atrial refractory period by 22% in dogs with atrial tachycardia induced electrical remodeling. ... During atrial fibrillation, this process becomes chaotic and the atrial depolarization occurs faster than it should causing the ... A recognized atrial selective drug target is Kv1.5, which is found in atria but not in ventricles. Kv1.5 carries the ultra ... Atrial fibrillation (AF) is an arrhythmia that occurs in 1-2% of the general population. AF is linked to several cardiac causes ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European thyroid journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ... It is usually calculated as left atrial volume index in terms of body surface area. The left atrial volume is commonly measured ... "Left Atrial Volume Index Is Associated With Cardioembolic Stroke and Atrial Fibrillation Detection After Embolic Stroke of ... The resulting index is referred to as left atrial volume index (LAVI): L A V I = A L B S A {\displaystyle LAVI={\frac {{A}_{L ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ... Probably as a consequence of non-thyroidal illness syndrome, SPINA-GD predicts mortality in trauma and postoperative atrial ... Correlations were also shown to age, total atrial conduction time, and concentrations of 3,5-diiodothyronine and B-type ...
... of miR-590 by nicotine has been found to play a key part in the generation of atrial fibrosis by atrial structural remodelling ... "Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovascular Research. ...
"Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovasc. Res. 83 (3): ... Torella D (2011). "MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo ...
"Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs". ... In a porcine model of left atrial remodeling following mitral regurgitation, VLC-2 was shown to be upregulated. Human ALC-2 is ... Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans ... In a canine model of atrial fibrillation, decreased atrial contractility was associated with decreased ALC-2 and myosin binding ...
A study showed a significant association of a specific polymorphism of the EDN2 gene with increased incidence of atrial ... Overall, the evidence suggests that ET-2 could modulate vascular tone, tissue morphology and remodelling. Since reports of ... December 2007). "A985G polymorphism of the endothelin-2 gene and atrial fibrillation in patients with hypertrophic ...
One reason for this may be that once the heart has undergone atrial remodeling as in the case of chronic atrial fibrillation ... AF therefore have an increased chance of success with an ablation since their heart has not undergone atrial remodeling yet.[ ... After 12 months, participants receiving catheter ablation were more likely to be free of atrial fibrillation, and less likely ... November 2016). "Efficacy and safety of ablation for people with non-paroxysmal atrial fibrillation". The Cochrane Database of ...
This is why atrial fibrillation almost never degrades to ventricular fibrillation. In youth, this collagen structure is free of ... Throughout life, the cardiac collagen skeleton is remodeled. Where collagen is diminished by age, calcium is often deposited, ... The AV node is the only electrical conduit from the atria to the ventricles through the cardiac skeleton, which is why atrial ...
The recently remodeled atrium looks better than ever with its new and spacious gardens that are home to different types of ... Its pink stone facade has a tower composed of three bodies; there are cross atrial figures of the Passion of the Christ and of ...
These thickenings will go on to fuse and remodel to eventually form the valves and septa of the mature adult heart. A problem ... Upon sectioning of the heart the atrioventricular endocardial cushions can be observed in the lumen of the atrial canal as two ... As heart development continues, this tube undergoes remodeling to eventually form the four-chambered heart. The endocardial ... in endocardial cushion development or remodeling is thought to be associated with atrioventricular septal defect. Endocardial ...
"2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial ... Left ventricular hypertrophy and left ventricular remodeling Diminished coronary flow reserve and silent myocardial ischemia ... often termed diastolic heart failure Atrial fibrillation, other cardiac arrhythmias, or sudden cardiac death Heart failure can ... hypertrophy in athletes Congestive heart failure or heart failure with normal ejection fraction due to other causes Atrial ...
It is also believed that angiotensin directly affects cardiac remodeling, and blocking its activity can thereby slow the ... Glucocorticoids induce a potent diuresis in heart failure because they could improve renal responsiveness to atrial natriuretic ... It is also thought that catecholamines and other sympathomimetics have an effect on cardiac remodeling, and blocking their ... These commonly involve surgical left ventricular remodeling. The aim of the procedures is to reduce the ventricle diameter ( ...
In vascular remodeling, Pcsk6 was found to induce smooth muscle cell migration in response to PDGFB by activating MMP14. When ... Pcsk6 KO mice was shown to develop salt-sensitive hypertension due to failure of pro-corin activation crucial to atrial ... "PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling". Circulation Research. 126 (5): ...
This suggests that budiodarone may promote atrial re-modelling to improve malfunctioning ion channels that once potentiated ... In addition to reductions in atrial fibrillation burden, similar dose-dependent reductions in the number of atrial fibrillation ... "Amiodarone to prevent recurrence of atrial fibrillation. Canadian Trial of Atrial Fibrillation Investigators". The New England ... in patients with paroxysmal atrial fibrillation and pacemakers with atrial fibrillation data logging capabilities. Heart Rhythm ...
For example, MMP9 appears to be involved in the remodeling associated with malignant glioma neovascularization. It is also a ... MMP9 levels increase with the progression of idiopathic atrial fibrillation. MMP9 has been found to be associated with the ... Gelatinase B plays a central role in tumor progression, from angiogenesis, to stromal remodeling, and ultimately metastasis. ... which are key effectors of ECM remodeling. MMP9, along with elastase, appears to be a regulatory factor in neutrophil migration ...
Intermittent use of a short-course glucagon-like peptide-1 receptor agonist therapy limits adverse cardiac remodeling via ... Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass. JCI ... "Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass". JCI ...
Other intrinsic causes include inherited ion channel dysfunctions, remodeling diseases such as heart failure and atrial ... or remodeling of the sinus node while extrinsic causes can create or worsen underlying atrial arrhythmias. Intrinsic causes ... or tachycardia-bradycardia syndrome presenting as various atrial arrhythmias such as atrial fibrillation, flutter, tachycardia ... Drago F, Silvetti MS, Grutter G, De Santis A (1 July 2006). "Long term management of atrial arrhythmias in young patients with ...
... , also called atrial natriuretic peptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene. ... Corin-mediated ANP production in the pregnant uterus promotes spiral artery remodeling and trophoblast invasion. CORIN ... Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt- ... Wu F, Yan W, Pan J, Morser J, Wu Q (May 2002). "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes". The ...
Working on sino atrial node cells by inhibiting T-type calcium channel activation, Efonidipine prolongs the late phase-4 ... By reducing synthesis and secretion of aldosterone, Efonidipine prevents hypertrophy and remodeling of cardiac myocytes. ... depolarization of the sino atrial node action potential and suppresses an elevated HR. The negative chronotropic effect of ...
It also interacts with other genes, such as GATA4 and NKX2-5, and the BAF chromatin-remodeling complex to drive and repress ... Mice that only had one working copy of TBX5 were born with morphological problems such as enlarged hearts, atrial and ventral ... Cardiac defects include ventral and atrial septation and problems with the conduction system. Several transcript variants ...
... congenital heart disease such as atrial septal defect, and ischemic heart disease. In addition, a right bundle branch block may ... Causes for incomplete right bundle branch block are exercise-induced right ventricular remodeling, increased RV free wall ...
During atrial fibrillation atrial remodeling takes place. Atrial remodeling refers to changes in the atria, including ... The aim of this thesis was to investigate this atrial remodeling. The focus is on remodeling caused by stretch (mimicking these ... First, different aspects of structural atrial remodeling are reviewed with a special focus on stretch and its contribution to ... Atrial fibrillation is the most common cardiac arrhythmia. Risk factors for atrial fibrillation include older age, hypertension ...
Left Atrial Remodeling Not Found After 1 Year of Nocturnal HD While left ventricular mass has been shown to regress with ...
AF was maintained electrically (x1 week) in dogs by right-atrial (RA) tachypacing. ACMs isolated from AF-dogs showed increased ... Here, we examined the effects of AF-associated remodeling on Ca2+-related action-potential (AP) dynamics and consequences for ... alters atrial-cardiomyocyte (ACM) Ca2+-handling, promoting ectopic-beat formation. ... Altered calcium-handling produces reentry-promoting action potential alternans in atrial fibrillation-remodeled hearts.. Apr 15 ...
Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model ... Dive into the research topics of Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro- ...
Left atrial (LA) size is often used as a surrogate marker of LA function in clinical practice, with larger atria thought to ... Melenovsky V, Hwang SJ, Redfield MM, Zakeri R, Lin G, Borlaug BA: Left atrial remodeling and function in advanced heart failure ... Left Atrial Phasic Function Remodeling During Its Enlargement: a Two-dimensional Speckle-tracking Echocardiography Study ... Park JJ, Park JH, Hwang IC, Park JB, Cho GY, Marwick TH: Left Atrial Strain as a Predictor of New-Onset Atrial Fibrillation in ...
Atrial reverse remodelling was defined as a a parts per thousand yen10% reduction in left atrial volume index at 6-month follow ... Atrial reverse remodelling was defined as a a parts per thousand yen10% reduction in left atrial volume index at 6-month follow ... Atrial reverse remodelling was defined as a a parts per thousand yen10% reduction in left atrial volume index at 6-month follow ... Atrial reverse remodelling was defined as a a parts per thousand yen10% reduction in left atrial volume index at 6-month follow ...
Arterial hypertension as the risk factor of the worse left atrial remodeling in patients undergoing pulmonary vein isolation. ...
... of the role of miR-31-dependent reduction in dystrophin and nNOS on atrial-fibrillation-induced electrical remodelling in man ... of the role of miR-31-dependent reduction in dystrophin and nNOS on atrial-fibrillation-induced electrical remodelling in man ...
title = "MicroRNA-133 suppresses ZFHX3-dependent atrial remodelling and arrhythmia",. abstract = "Aim: Atrial fibrillation (AF ... Cheng, WL, Kao, YH, Chao, TF, Lin, YK, Chen, SA & Chen, YJ 2019, MicroRNA-133 suppresses ZFHX3-dependent atrial remodelling ... MicroRNA-133 suppresses ZFHX3-dependent atrial remodelling and arrhythmia. Wan Li Cheng, Yu Hsun Kao, Tze Fan Chao, Yung Kuo ... MicroRNA-133 suppresses ZFHX3-dependent atrial remodelling and arrhythmia. / Cheng, Wan Li; Kao, Yu Hsun; Chao, Tze Fan et al. ...
Predictors and prognostic value of left atrial remodelling after acute myocardial infarction ... Predictors and prognostic value of left atrial remodelling after acute myocardial infarction ... Predictors and prognostic value of left atrial remodelling after acute myocardial infarction ...
Patients with complete progression of AER, from paroxysmal AF episodes to electrically remodelled persistent AF, were used to ... Atrial activation rate (AAR) was quantified as the frequency of the dominant peak in the signal spectrum of AF episodes with ... is a transitional period associated with the progression and long-term maintenance of atrial fibrillation (AF). We aimed to ... Atrial fibrillation. , Atrial fibrillation progression. , Electrical remodeling. , Implantable cardioverter-defibrillator. , ...
Atrial fibrillation is the most common type of cardiac arrhythmia, and is responsible for substantial morbidity and mortality ... This Review focuses on the mechanistic rationale for the development of new anti-atrial fibrillation drugs, on the molecular ... Dobrev and colleagues discuss the rationale for developing new anti-atrial fibrillation drugs, the molecular and structural ... efforts have been invested in developing novel treatments that target the underlying molecular determinants of atrial ...
Backgrounds: Alterations in the atrial structure and function associated with aging result in electric remodeling of the left ... T1 - The extent of complex fractionated atrial electrograms in the left atrium reflects age-related electrical remodeling in ... N2 - Backgrounds: Alterations in the atrial structure and function associated with aging result in electric remodeling of the ... AB - Backgrounds: Alterations in the atrial structure and function associated with aging result in electric remodeling of the ...
Morphologic remodeling of pulmonary veins and left atrium after catheter ablation of atrial fibrillation: Insight from long- ... Dive into the research topics of Morphologic remodeling of pulmonary veins and left atrium after catheter ablation of atrial ...
Further, multiple microRNAs (miRNAs) are reported to be involved in atrial remodeling and AF pathogenesis, so we investigated ... 47%, odds ratio 2.12, p = 4.9 × 10−26). Corrected sinus node recovery time (CSRT) was longer and left atrial volume index (LAVI ... These findings strongly implicate rs6817105 minor allele in sinus node dysfunction and left atrial enlargement. ... on chromosome 4q25 with atrial fibrillation (AF), but phenotype alterations conferred by this SNP have not been described. We ...
... excess uric acid may have a link to remodeling of the left atrium. ... These studies point to associations between UA levels and left atrial remodeling and the risk for AF. Chao and colleagues ... The association between hyperuricemia, left atrial size and new-onset atrial fibrillation. Int J Cardiol. 2013;168:4027-4032. ... and increased left atrial size. The association with increased left atrial size persisted after multivariable adjustment. In ...
However, atrial natriuretic peptide is thought to be cardio-protective. Remodeling of the heart is evaluated by performing an ... Physiological remodeling is reversible while pathological remodeling is mostly irreversible. Remodeling of the ventricles under ... In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of ... This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling ...
Histological validation of atrial structural remodelling in patients with atrial fibrillat Histological validation of atrial ... Fibrilação Atrial; Remodelamento Atrial; Ablação por Cateter; Humanos; Feminino; Pessoa de Meia-Idade; Idoso; Fibrilação Atrial ... This study aimed to histologically validate atrial structural remodelling associated with atrial fibrillation. METHODS AND ... Histological correlates of atrial structural remodelling were fibrosis, increased intercellular space, myofibrillar loss, and ...
Detection of Atrial Fibrillation After Central Retinal Artery Occlusion  Mac Grory, Brian; Landman, Sean R; Ziegler, Paul D; ... How the remodeled retinal circuit affects visual processing following rod rescue is not known. To address this question, we ... It is not known whether rescued neurons and the remodeled circuit will establish communication to regain normal function. We ... Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional ...
Right atrial dilatation was found in 34, left atrial dilatation in 36 and bi-atrial dilatation in 31 patients. Patients with a ... A longer duration of atrial fibrillation predisposes to atrial dilatation, left ventricular dysfunction, and functional atrio- ... A history of atrial fibrillation of over 6 months was associated with enlarged atria, reduced left ventricular shortening ... In this study we sought to examine the relationship between right atrial dilatation and left ventricular function in patients ...
Human atrial fibrillation is not associated with remodeling of ryanodine receptor clusters. Frontiers in Cell & Developmental ... Measurement of exhaled nitric oxide fails to predict left atrial pressure assessed by E/e ratio in elderly patients. BJGP Open ... Cardiac fibrosis in right atrial tissue is not different in male Pasifika and Pākehā cardiac surgery patients in Aotearoa. ... effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism, 319, ...
Insufficient leaflet remodeling in patients with atrial fibrillation. Circulation 2017;10.doi:10.1161/CIRCIMAGING.116.005451 ... Proportionate SMR refers to the situation where the extent of EROA or RV is expected based on the degree of LV remodelling or ... Left ventricular reverse remodelling predicts long-term outcomes in patients with functional mitral regurgitation undergoing ... between the magnitude of reduction in mitral regurgitation severity and left ventricular and left atrial reverse remodeling ...
Atrial fibrillation (AF) has strong associations with other cardiovascular diseases, such as heart failure, coronary artery ... Regional left atrial interstitial remodeling in patients with chronic atrial fibrillation undergoing mitral-valve surgery. ... Shi Y, Li D, Tardif JC, Nattel S. Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive ... As AF contributes to pathologic atrial and ventricular remodeling, restoration of sinus rhythm can slow or, in some cases, ...
Atrial fibrillation is associated with electrical and structural remodeling; thus early intervention with a rhythm control ... Atrial fibrillation. Lancet 2012;126:860-5.. *Olshansky B, Rosenfeld LE, Warner AL, et al. The Atrial Fibrillation Follow-up ... Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European ... Keywords: Anti-Arrhythmia Agents, Anticoagulants, Aspirin, Atrial Fibrillation, Benzimidazoles, Catheter Ablation, ...
... oxidase activation on mitochondrial dysfunction and ventricular remodeling in the diabetic mouse model. Hyperglycemia-induced ... thereby reducing ventricular remodeling and the incidence of DCM. ... Rac1 expression can improve diabetes-related atrial remodeling ... Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the ... Activation of NADPH oxidase mediates mitochondrial oxidative stress and atrial remodeling in diabetic rabbits. Life Sci. 2021, ...
Early intervention is essential to decrease the electrical, contractile, and structural atrial remodeling that occurs during AF ... CHADS2 Score for Stroke Risk Assessment in Atrial Fibrillation * International Normalized Ratio (INR) Targets: Atrial ... Atrial fibrillation (AF), the most common cardiac arrhythmia, is often associated with other cardiovascular (CV) diseases, ... When Should Anticoagulation for Stroke be Initiated in Patients With Atrial Fibrillation? 0.25 CME / CE / ABIM MOC Credits ...
Experimental study for the mechanisms of atrial remodeling. Cardiovascular Imaging: Intravascular ultrasound evaluation of ... Therapeutic effect of catheter ablation and implantable cardioverter defibrillator for treatment of patients with atrial or ...
Left atrial remodeling in response to aortic valve replacement: pathophysiology and myocardial strain analysis ... Left atrial myocardial intrinsic function remodeling response to repair of primary mitral regurgitation ... Left atrial strain by speckle tracking predicts atrial fibrosis in patients undergoing heart transplantation ... Left atrial stiffness predicts cardiac events in patients with heart failure and reduced ejection fraction: The impact of ...
A septal bulge depicts more advanced cardiac impairment in patients with hypertension: the case of atrial remodelling Author(s ... Impact of anatomical reverse remodelling in the design of optimal quadripolar pacing leads: A computational study Author(s): ... Detection of focal source and arrhythmogenic substrate from body surface potentials to guide atrial fibrillation ablation ... Association of Systolic Blood Pressure Elevation With Disproportionate Left Ventricular Remodeling in Very Preterm-Born Young ...
4. Nattel S, Burstein B, Dobrev D. Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications. Circ Arrhythm ... Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via ... Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by over-expression of ... 2. Corradi D, Callegari S, Maestri R, Benussi S, Alfieri O. Structural remodeling in atrial fibril- ation. Nat Clin Pract ...
  • Maximal left atrial volume measured echocardiographically in population-based studies is an independent determinant of cardiovascular events, including atrial fibrillation, congestive heart failure, and stroke. (medscape.com)
  • It is well known that angiotensin-converting enzyme (ACE) inhibitors and angiotensin-II type I receptor blockers (ARBs) are not only effective in treating hypertension but also in reducing the morbidity and mortality in various disease conditions including atrial fibrillation (AF), 1 coronary artery disease (CAD), 2 and congestive heart failure (CHF). (jafib.com)
  • Abhayaratna and coworkers prospectively studied 574 adults older than 65 (mean age 74±6) in sinus rhythm without a history of atrial arrhythmia, stroke, valvular or congenital heart disease that were referred for a clinically indicated echocardiogram. (medscape.com)
  • the prevalence of hypertension, diabetes, heart failure, prior myocardial infarction and the use of cardioactive medications were similar in those with and without atrial arrhythmia. (medscape.com)
  • The maximum LA volume (47±17 vs. 40±14 ml/m 2 ) and minimum LA volume (29±3 vs. 21±9 ml/m 2 ) were greater and the LA emptying index was less (38± 12% vs. 49± 11%), and grade II-IV diastolic dysfunction was more common (37 vs. 19%) in those with than without a first atrial arrhythmia. (medscape.com)
  • After correcting for age, LA emptying fraction = 49% (HR 6.5) and LA maximum volume = 38 ml/m 2 (HR 2.0) predicted atrial arrhythmia, and both were independent predictors in a multivariable analysis that controlled for baseline clinical variables, LV ejection fraction and diastolic dysfunction. (medscape.com)
  • They speculate that abnormal reservoir function (functional or mechanical remodeling) represents a more advanced stage of atrial remodeling than atrial size alone (structural remodeling), and that the remodeling process is a determinant of atrial arrhythmia, independent from clinical risk factors and LV function. (medscape.com)
  • Recognition of electrical remodeling as a phenomenon provides new opportunities for development of novel arrhythmia control and prevention strategies before persistent changes occur. (nih.gov)
  • However, if often causes disease of the myocardium, such as heart failure, linked to the severity of DMR, and ventricular or atrial dysfunction or arrhythmia. (nih.gov)
  • The changes in left atrial (LA) size and function are related to the occurrence of arrhythmia. (researchsquare.com)
  • The exclusion criteria in both groups included cardiovascular disease, such as history of atrial arrhythmia, hypertrophic cardiomyopathy, and severe valvular disease, and poor image quality for myocardial speckle tracing analysis. (researchsquare.com)
  • Atrial fibrillation is the most common type of cardiac arrhythmia. (nih.gov)
  • Atrial fibrillation represents the most common arrhythmia leading to increased morbidity and mortality, yet, current treatment strategies have proven inadequate. (nih.gov)
  • Segment of an ECG showing atrial fibrillation, a rapid arrhythmia of the heart. (medscape.com)
  • PURPOSE The objective of this initiative is to elucidate mechanisms responsible for functional, molecular, and structural myocardial changes due to electrical remodeling and leading to arrhythmias. (nih.gov)
  • Our simulations complement and extend previous studies aimed at understanding key factors by which decreases in [K + ] o can produce effects that are known to promote atrial arrhythmias in human hearts. (frontiersin.org)
  • Atrial fibrillation (AF) is one of the most common arrhythmias and associated with heart failure [ 1 - 4 ]. (hindawi.com)
  • Experimental and clinical evidence suggests that mechanical stress leads to myocardial inflammation, fibrosis, and remodeling that creates the electrophysiological substrate responsible for SCA/SCD and other serious ventricular arrhythmias. (nih.gov)
  • Lower heart rate is associated with preservation of energy substrate in the myocardium, allowing reverse remodeling, and may result in fewer arrhythmias. (medpagetoday.com)
  • Atrial fibrillation is one of the most common arrhythmias, affecting between 3 and 6 million adults in the US. (msdmanuals.com)
  • 3] Dynamic analysis of cardiac rhythms for discriminating atrial fibrillation from lethal ventricular arrhythmias . (nih.gov)
  • [ 6 ] The patients were followed for 1.9±1.2 years for the development of electrocardiographically-confirmed atrial fibrillation or flutter using questionnaires and review of medical records. (medscape.com)
  • Influence of left ventricular remodeling on atrial fibrillation recurrence and cardiovascular hospitalizations in patients undergoing rhythm-control therapy. (nih.gov)
  • Post-cardioversion time Course of Atrial Remodeling Markers and their Association with Recurrence in Subjects with Long-standing, Persistent Atrial Fibrillation. (bvsalud.org)
  • Activation of the renin - angiotensin - aldosterone axis with elevation of inflammatory markers and the resulting fibrosis play a very important role in atrial remodeling in patients with atrial fibrillation (AF), which is associated with post- cardioversion recurrence . (bvsalud.org)
  • 5. Left atrial strain for predicting recurrence in patients with non-valvular atrial fibrillation after catheter ablation: a single-center two-dimensional speckle tracking retrospective study. (nih.gov)
  • The primary endpoints were defined as a new development and/or recurrence of atrial fibrillation (AF). (jafib.com)
  • I coordinate studies on electrical, contractile, and structural remodeling in heart failure and atrial fibrillation. (maastrichtuniversity.nl)
  • miRNAs play a variety of roles in atrial fibrillation, including regulation of electrical remodeling and modulation of structural remodeling of cardiac tissue. (hindawi.com)
  • Therefore, in the first part of the thesis, we studied early hypertension-induced structural and functional (Ca2+ handling) remodeling of left ventricular (LV) myocytes and nuclei. (uni-marburg.de)
  • In the second part of the thesis, we studied structural and functional nuclear remodeling in advanced hypertension. (uni-marburg.de)
  • It had been suggested that omega-3 fatty acids and vitamin D might prevent Afib due to their electrophysiologic effects on atrial structural and electrical remodeling. (medpagetoday.com)
  • Therefore, the goal of the study is to directly test the hypotheses that inhibition of the soluble epoxide hydrolase enzyme can result in an increase in the levels of epoxyeicosatrienoic acids, leading to the attenuation of atrial structural and electric remodeling and the prevention of atrial fibrillation.For the first time, we report findings that inhibition of soluble epoxide hydrolase reduces inflammation, oxidative stress, atrial structural, and electric remodeling. (nih.gov)
  • Proarrhythmic atrial structural and molecular remodeling with advancing age. (escardio.org)
  • Using the American Society of Echocardiography (ASE) criteria, patients were divided into 4 categories: 1) normal geometry, 2) concentric remodeling, 3) eccentric hypertrophy, and 4) concentric hypertrophy. (nih.gov)
  • ECG gated Echocardiography with measurement of atrial electromechanical coupling (PA), left atrial intra-AEMD over a period of 1 year from July 2017 to July 2018 in Mansoura specialized medical hospital. (scirp.org)
  • Determining electromechanical intervals as the atrial conduction interval with transthoracic echocardiography is a simple, easy bedside method to be evaluated. (scirp.org)
  • The whole patients were assessed by way of thorough records taking, medical examination, twelve lead surface (ECG), ECG gated echocardiography with assessment of atrial electromechanical coupling (PA), left atrial intra-AEMD over a period of 1 year from July 2017 to July 2018 in department of cardiovascular medicine, Faculty of Medicine, Mansoura University. (scirp.org)
  • 8. Interaction effect of hypertension and obesity on left atrial phasic function: a three-dimensional echocardiography study. (nih.gov)
  • 13. Left atrial reservoir strain is an outstanding predictor of adverse cardiovascular outcomes in patients undergoing maintenance hemodialysis: Assessment via three-dimensional speckle tracking echocardiography. (nih.gov)
  • 18. Real-time three-dimensional echocardiography of left atrial volume and function in patients with severe multi-vessel coronary artery disease. (nih.gov)
  • The present study was designed to measure LA conventional echocardiography and LA strain and strain rate parameters in patients with paroxysmal atrial fibrillation, then to analyze the difference between stroke/ transient ischemic attack (TIA) and non-stroke/TIA patients, and to explore relationship between the impaired deformability of LA and stroke/TIA events and its predictive value for stroke/TIA events. (researchsquare.com)
  • The study enrolled 365 consecutive patients (222 were male, 58.95±10.52 years old) who underwent pre-procedural transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) before radiofrequency catheter ablation (RFCA) for symptomatic drug-refractory paroxysmal AF in Beijing Anzhen Hospital Atrial fibrillation center, Capital Medical University from January 2017 to June 2020. (researchsquare.com)
  • A common scenario for remodeling is after myocardial infarction. (wikipedia.org)
  • The initial remodeling phase after a myocardial infarction results in repair of the necrotic area and myocardial scarring that may, to some extent, be considered beneficial since there is an improvement in or maintenance of LV function and cardiac output. (wikipedia.org)
  • MVP can lead to excessive mechanical stress on the ventricles and the atria, and possibly to myocardial inflammation, fibrosis, and remodeling. (nih.gov)
  • Here, we assessed the medium-term electrophysiologic remodeling after intra-myocardial GH administration in (n = 33) rats. (researchgate.net)
  • Growth hormone, currently under evaluation for the prevention of left ventricular remodeling post-myocardial infarction, displays antiarrhythmic properties in the acute setting. (researchgate.net)
  • Dysregulation of miR1 has been associated with various heart diseases, where a significant reduction (>75%) in miR1 expression has been observed in patient hearts with atrial fibrillation or acute myocardial infarction. (cdc.gov)
  • 1-6 The impact of physical activity on the risk of atrial fibrillation (AF) appears to be more complex. (bmj.com)
  • The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis. (cdc.gov)
  • There are many causes of atrial fibrillation (AF), but it shares a strong association with other cardiovascular diseases. (nih.gov)
  • Identify the etiology of atrial fibrillation. (nih.gov)
  • Indeed, reservoir function calculated using atrial strain and strain rates during ventricular systole (measures of atrial distensibility and reservoir capacity, respectively) were reduced in patients with atrial fibrillation compared with controls and predicted independently the maintenance of sinus rhythm after cardioversion. (medscape.com)
  • This activity describes the evaluation, diagnosis, and management of atrial fibrillation and highlights the role of team-based interprofessional care for affected patients. (nih.gov)
  • It is associated with atrial remodeling that finally leads to atrial fibrillation (AF). (scirp.org)
  • Although rate control is important to stabilizing patients with AF, restoring sinus rhythm can slow or reverse the atrial and ventricular remodeling that leads to atrial dilation and left ventricular dysfunction. (medscape.com)
  • Especially interested on investigating novel therapeutic approaches to achieve functional recovery through enhancing the reparative processes of the of the damaged myocardium and reversal of adverse heart remodeling. (biomedcentral.com)
  • Main research topics are: Adaptation processes of excitation-contraction coupling in ventricular and atrial myocardium, cellular and integrated action of antiarrhythmic drugs, and the development of substrates for the perpetuation of atrial fibrillation. (maastrichtuniversity.nl)
  • This was a cross-sectional study in patients with idiopathic atrial fibrillation. (revespcardiol.org)
  • Myocytes were isolated enzymatically from the right atrial appendage of 40 consenting patients who were in sinus rhythm. (gla.ac.uk)
  • 11-13 patients) was not associated with any significant changes in atrial cell electrophysiology. (gla.ac.uk)
  • BACKGROUND: Atrial fibrillation (AF) patients with left ventricular hypertrophy (LVH) and diastolic dysfunction may derive benefit from being in sinus rhythm but no data are available to support this strategy in them. (nih.gov)
  • We sought to investigate effect of left ventricular remodeling on cardiovascular outcomes in AF patients undergoing rhythm control strategy. (nih.gov)
  • Ventriculoatrial remodeling in patients with recurrent atrial fibrillation and diastolic dysfunction: does gender matter? (rudn.ru)
  • among them, 221 (61%) were in sinus rhythm and had no prior atrial fibrillation (AF), and 144 patients (39%) had a history of AF. (rug.nl)
  • Cox regression analysis revealed that patients with no atrial and no ventricular reverse remodelling had the worst outcome (hazard ratio 3.1, 95% confidence interval 1.4-7.1, P = 0.006). (rug.nl)
  • Outcome in patients with only atrial reverse remodelling was comparable with outcome in patients with both atrial and ventricular reverse remodelling (hazard ratio 2.0, 95% confidence interval 0.7-5.6, P = 0.21). (rug.nl)
  • Patients without atrial and ventricular reverse remodelling have the worst outcome. (rug.nl)
  • Patients with only atrial reverse remodelling have improved left ventricular diastolic filling during follow-up and demonstrate a comparable outcome with patients with both atrial and ventricular reverse remodelling. (rug.nl)
  • abstract = "To study the prognostic effect of atrial reverse remodelling on outcome of cardiac resynchronization therapy (CRT).Patients receiving a CRT device in the University Medical Centre Groningen were included. (rug.nl)
  • Other anatomic considerations in evaluating patients prior to PMBV include exclusion of left atrial thrombus and severe mitral regurgitation , both of which are contraindications to the procedure (see Contraindications section below). (medscape.com)
  • Increased AEMDs can be used as indicators to differentiate patients with recent onset atrial fibrillation from controls without recent onset AF or to expect the occurrence of recent attack of AF as in studies [1]. (scirp.org)
  • 1. Four-dimensional quantification on left atrial volume-strain in coronary heart disease patients without regional wall motion abnormalities: Correlation with the severity of coronary stenosis. (nih.gov)
  • 2. Echocardiographic evaluation of left atrial strain for predicting iron overload in pediatric patients with β-thalassemia with preserved ejection fraction. (nih.gov)
  • 4. Correlation of left atrial strain with left ventricular end-diastolic pressure in patients with normal left ventricular ejection fraction. (nih.gov)
  • 9. Left atrial reservoir strain combined with E/E' as a better single measure to predict elevated LV filling pressures in patients with coronary artery disease. (nih.gov)
  • 17. Decreased left atrial function in obesity patients without known cardiovascular disease. (nih.gov)
  • Approximately in half of the patients after coronary artery bypass surgery, atrial fibrillation (AF) is developed. (nature.com)
  • First, patients with AF may require a higher heart rate to counteract the diminished stroke volume due to the loss of atrial kick. (medpagetoday.com)
  • Aim: Peri-procedural thromboembolic (TE) and hemorrhagic events are complications of major concern for patients undergoing cryoballoon (CB) ablation for atrial fibrillation (AF). (researchgate.net)
  • Although atrial fibrillation may be a permanent disease, various treatments and risk modifying strategies have been developed to help reduce the risk of stroke in patients that remain in atrial fibrillation. (nih.gov)
  • Explain the interprofessional team strategies for improving care coordination and communication regarding the management of patients with atrial fibrillation. (nih.gov)
  • Stroke is a kind of serious complication in patients with atrial fibrillation (AF). (researchsquare.com)
  • When Should Anticoagulation for Stroke be Initiated in Patients With Atrial Fibrillation? (medscape.com)
  • Atrial fibrillation tends to occur in patients with an underlying heart disorder. (msdmanuals.com)
  • Permanent atrial fibrillation cannot be converted to sinus rhythm (the term also includes patients for whom a decision has been made not to attempt conversion to sinus rhythm). (msdmanuals.com)
  • She is now pursuing research interests in treating inflammation and obesity to help manage atrial fibrillation, while training in clinical cardiology. (biomedcentral.com)
  • Any condition that leads to inflammation, stress, damage, or ischemia affecting the anatomy of the heart can result in the development of atrial fibrillation. (nih.gov)
  • Following, Vennela worked as a PhD research fellow at Imperial College London running a multi-centre randomised controlled trial comparing ablation strategies in non-paroxysmal atrial fibrillation, which was funded by National Institute of Health Research (NIHR). (biomedcentral.com)
  • We utilized the patch clamp technique to characterize the electrical remodelling associated with enhanced TRPC3 expression in cardiac myocytes. (biomedcentral.com)
  • Besides, reduced expression of V1 myosin and L-type calcium channels on cardiac myocytes are also thought to cause cardiac remodeling. (wikipedia.org)
  • Michael Haude, MD, PhD. Percutaneous Coronary Sinus-Based Mitral Valve Annuloplasty in Atrial Functional Mitral Regurgitation. (cardiacdimensions.com)
  • Transcatheter indirect mitral annuloplasty induces annular and left atrial remodelling in secondary mitral regurgitation. (cardiacdimensions.com)
  • Implications for post-coronary artery bypass grafting atrial fibrillation occurrence. (escardio.org)
  • abstract = "Prevalence rates of atrial fibrillation (AF) and obstructive sleep apnea (OSA) are rising on a global scale. (edu.au)
  • Studies of atrial fibrillation (AF) due to atrial tachycardia have provided insights into the remodeling mechanisms by which "AF begets AF" but have not elucidated the substrate that initially supports AF before remodeling occurs. (nih.gov)
  • A progressive shift in intracellular [Na + ] i causes a change in the outward electrogenic current generated by the Na + /K + pump, thereby modifying V r and AP repolarization and changing the human atrial electrophysiological substrate. (frontiersin.org)
  • Atrial fibrillation substrate mapping with decrement evoked potential mapping. (escardio.org)
  • Risk factors for atrial fibrillation include advanced age, high blood pressure, underlying heart and lung disease, congenital heart disease, and increased alcohol consumption. (nih.gov)
  • Workman, A.J. , Kane, K.A. , Russell, J.A. , Norrie, J. and Rankin, A.C. (2003) Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling. (gla.ac.uk)
  • The importance of atrial compliance and reservoir function in normal physiology is well documented: the dissipation of energy stored in the left atrium during ventricular systole acts a restorative force during early diastolic LV filling, and atrial compliance is an important determinant of atrial systolic shortening and cardiac performance. (medscape.com)
  • Left atrial pressure is determined by the transvalvular gradient, which is a function of both orifice area and diastolic filling time. (medscape.com)
  • We aimed to investigate electrophysiological changes in human atrial cells associated with chronic treatment with β-blockers and other cardiovascular-acting drugs. (gla.ac.uk)
  • The aim of this study was to clarify how dysfunctional EAT promotes maladaptive heart remodeling in cardiovascular disease (CVD) through ST2 production associated with exchange protein directly activated by cAMP (EPAC) proteins. (uni-regensburg.de)
  • Chronic hypertension, congenital heart disease with intracardiac shunting, and valvular heart disease may also lead to remodeling. (wikipedia.org)
  • Genomic contributors to atrial electroanatomical remodeling and atrial fibrillation progression: Pathway enrichment analysis of GWAS data. (cdc.gov)
  • We hypothesized that maladaptive remodeling of nuclear structure and nuclear Ca2+ signaling might occur early in hypertension triggering initiation and progression of hypertrophy, and in advanced hypertension contributing to the transition from compensated hypertrophy to heart failure. (uni-marburg.de)
  • The observed remodeling of nuclear Ca2+ handling might represent an early event in hypertension that contributes to initiation and progression of pathological hypertrophy in hypertensive heart disease. (uni-marburg.de)
  • Our results suggest a pivotal role of TRPC channels in cardiac electrical remodelling associated with maladaptive hypertrophy. (biomedcentral.com)
  • 0.0001) protein imbalance associated with maladaptive remodeling. (uni-regensburg.de)
  • To study the prognostic effect of atrial reverse remodelling on outcome of cardiac resynchronization therapy (CRT). (rug.nl)
  • Action potential-clamp experiments as well as mathematical modelling attempts were performed to delineate the consequences of TRPC3 overexpression and to analyze the mechanisms of TRPC3-mediated electrical remodelling in the heart. (biomedcentral.com)
  • Ninety-nine subjects with long-standing, persistent, non-valvular atrial fibrillation who underwent successful electrical cardioversion were included, with a 6 month follow up. (bvsalud.org)
  • Electrical remodeling represents a persistent alteration in cardiac characteristics after a temporary, abnormal heart rhythm change. (nih.gov)
  • For instance, electrical remodeling accounts for the maintained shortening of atrial refractoriness after transient heart rate increases. (nih.gov)
  • Atrial electromechanical coupling delays are the time intervals between the electrical depolarization of the atria and start of atrial mechanical activity. (scirp.org)
  • Prolonged Atrial electromechanical delay reflects the electrical remodeling of the left atrium, which is important for maintenance of AF [2]. (scirp.org)
  • In atrial fibrillation, the atria do not contract, and the atrioventricular (AV) conduction system is bombarded with many electrical stimuli, causing inconsistent impulse transmission and an irregularly irregular ventricular rate, which is usually in the tachycardia rate range. (msdmanuals.com)
  • We have used mathematical models of the human atrial action potential (AP) to explore the electrophysiological mechanisms that underlie changes in resting potential (V r ) and the AP following decreases in plasma K + , [K + ] o , that were selected to mimic clinical hypokalemia. (frontiersin.org)
  • In 2003, he defended his thesis "Mechanisms of Atrial Paralysis in Atrial Fibrillation" at Maastricht University. (maastrichtuniversity.nl)
  • Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. (nih.gov)
  • Activation of the renin-angiotensin-system seems to be involved in atrial enlargement, with release of atrial and brain natriuretic peptides. (revespcardiol.org)
  • The aim of this study was to evaluate the relationship between ambulatory blood pressure and levels of natriuretic peptides, with left atrial size in normotensives with idiopathic atrial fibrillation. (revespcardiol.org)
  • The following measurements were recorded during the course of the study: office and 24-h ambulatory blood pressure, atrial and brain natriuretic peptides, plasma renin, aldosterone, and angiotensin-converting enzyme. (revespcardiol.org)
  • However, atrial natriuretic peptide is thought to be cardio-protective. (wikipedia.org)
  • 3. Prognostic Value of Left Atrial Strain in Aortic Stenosis: A Competing Risk Analysis. (nih.gov)
  • 6. Impact of different degrees of left ventricular strain on left atrial mechanics in heart failure with preserved ejection fraction. (nih.gov)
  • 10. The novel left atrial strain parameters in diagnosing of heart failure with preserved ejection fraction. (nih.gov)
  • Our group has demonstrated a reduction in the LV global longitudinal strain in strength athletes, which was analyzed using the non-invasive pressure-strain loop area, LV remodeling, and subclinical changes in LV systolic function[3]. (researchsquare.com)
  • Success of CRT was defined as ventricular reverse remodelling with a reduction in left ventricular end-systolic volume of a parts per thousand yen15% at 6-month follow-up. (rug.nl)
  • Ultimately, ventricular remodeling may result in diminished contractile (systolic) function and reduced stroke volume. (wikipedia.org)
  • Both EPAC2 and ST2 expression were directly related to maladaptive heart remodeling indices, suggesting EAT measurements could be useful in the early assessment of CVD complications. (uni-regensburg.de)
  • Initially, hypertrophy is beneficial, but chronic activation of neurohormonal mediators and altered Ca2+ signaling ultimately lead to maladaptive alterations in gene expression and progressive cardiac remodeling, which eventually becomes detrimental and impairs cardiac function. (uni-marburg.de)
  • however, CHF dogs had a substantial increase in the heterogeneity of conduction during atrial pacing (heterogeneity index in CHF dogs, 2. (nih.gov)
  • Besides, the cardiac interstitium which consisted of largely Type I and Type III collagen fibres are also involved in cardiac remodeling. (wikipedia.org)
  • Two important Ca2+-dependent signaling pathways involved in cardiac remodeling are the Ca2+/calmodulin-dependent protein phosphatase calcineurin (CaN)-NFAT-GATA4/6 and the Ca2+/calmodulin-dependent protein kinase II (CaMKII)-HDAC-MEF2 pathway. (uni-marburg.de)
  • Atrial conductivity abnormalities were evaluated by simple non-invasive strategies with the use of electrocardiography and tissue Doppler imaging (TDI) as in previous studies [8] [9]. (scirp.org)
  • In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of the heart. (wikipedia.org)
  • This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling). (wikipedia.org)
  • Over time, however, as the heart undergoes ongoing remodeling, it becomes less elliptical and more spherical. (wikipedia.org)
  • Remodeling of the heart is evaluated by performing an echocardiogram. (wikipedia.org)
  • With exercise, heart rate and cardiac output increase, leading to an increase in left atrial and pulmonary arterial pressures. (medscape.com)
  • Mild reduction, with MVA measuring 2.0-2.5 cm 2 , results in elevated left atrial pressures when blood flow or heart rate is increased. (medscape.com)
  • Does left atrial volume affect exercise capacity of heart transplant recipients? (uc.edu)
  • LA remodeling is an integral part of the "athlete's heart" that is often ignored. (researchsquare.com)
  • CONCLUSIONS: miR1 deficiency acts as a primary etiological factor in inducing cardiac remodeling via disrupting heart regulatory homeostasis. (cdc.gov)
  • Long-term changes in the electrophysiological parameters and/or anatomical structures of the HEART ATRIA that result from prolonged changes in atrial rate, often associated with ATRIAL FIBRILLATION or long periods of intense EXERCISE . (bvsalud.org)
  • 1] Mitochondrial ROS drive sudden cardiac death and chronic proteome remodeling in heart failure . (nih.gov)
  • Neither fish oil nor vitamin D supplementation worked in the long-term primary prevention of atrial fibrillation (Afib), according to the VITAL Rhythm study. (medpagetoday.com)