Pre-procedural prediction of termination of persistent atrial fibrillation by catheter ablation as an indicator of reverse remodeling of the left atrium. (1/11)
BACKGROUND: The pre-procedural prediction of atrial fibrillation (AF) termination by catheter ablation in patients with persistent AF has not been evaluated fully. The aim of this study was to evaluate the pre-procedural predictors of persistent AF termination by ablation associated with the possibility of reverse remodeling of the left atrium (LA). METHODS AND RESULTS: Seventy consecutive patients (mean age, 62+/-8 years) with persistent or long-standing persistent AF underwent ablation. They were divided into 2 groups: those with AF terminated by ablation (n=14; group 1) and those with AF terminated by cardioversion after ablation (n=56; group 2). The left atrial appendage (LAA) contraction velocity determined on transesophageal echocardiography was significantly decreased in group 2 as compared to group 1 (P<0.001). Kaplan-Meier analysis showed that the group 1 patients had a higher AF-free survival rate than those in group 2 during 12+/-4.1 months of follow-up (P=0.048). The LA reverse remodeling ratio, given as the volume difference between before and 3 months after ablation in group 1, was significantly greater after ablation than that in group 2 (25.8+/-13% vs. 15.0+/-15%, P=0.015). Multivariate logistic regression analysis indicated that the LAA contraction velocity was an independent predictor of persistent AF termination by ablation (P=0.018). CONCLUSIONS: The LAA contraction velocity was the only non-invasive pre-procedural predictor of persistent AF termination by ablation, indicating the possibility of reverse remodeling of the LA. (+info)Changes in microRNAs expression are involved in age-related atrial structural remodeling and atrial fibrillation. (2/11)
BACKGROUND: Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been implicated in the aging process and in the regulation of extracellular matrix proteins. However, their role in age-related cardiac remodeling and atrial fibrillation (AF) was not well understood. The present study was designed to decipher molecular mechanisms underlying age-related atrial structural remodeling and AF. METHODS: Three groups of dogs were studied: adult and aged dogs in sinus rhythm and with persistent AF induced by rapid atrial pacing. The expressions of microRNAs were measured by quantitative real-time polymerase chain reaction. Pathohistological and ultrastructural changes were tested by light and electron microscopy. Apoptosis index of myocytes was detected by TUNEL. RESULTS: Samples of atrial tissue showed the abnormal pathohistological and ultrastructural changes, the accelerated fibrosis, and apoptosis with aging and/or in AF dogs. Compared to the adult group, the expressions of microRNAs-21 and -29 were significantly increased, whereas the expressions of microRNAs-1 and -133 showed obvious downregulation tendency in the aged group. Compared to the aged group, the expressions of microRNAs-1, -21, and -29 was significantly increased in the old group in AF; contrastingly, the expressions of microRNA-133 showed obvious downregulation tendency. CONCLUSION: These multiple aberrantly expressed microRNAs may be responsible for modulating the transition from adaptation to pathological atrial remodeling with aging and/or in AF. (+info)An Angiotensin receptor blocker prevents arrhythmogenic left atrial remodeling in a rat post myocardial infarction induced heart failure model. (3/11)
(+info)Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing. (4/11)
(+info)MicroRNAs in pulmonary arterial remodeling. (5/11)
(+info)Left atrial endocardial fibrosis and intra-atrial thrombosis - landmarks of left atrial remodeling in rats with spontaneous atrial tachyarrhythmias. (6/11)
INTRODUCTION: Histological abnormalities are common findings in the left atria (LA) of atrial fibrillation (AF) patients. We aimed to assess LA histological abnormalities in our model of spontaneous atrial tachyarrhythmias in rats. MATERIALS AND METHODS: LA sampling was performed in 12 spontaneously hypertensive rats (SHRs) and eight age-matched Wistar-Kyoto (WKY) rats. Tissue sections were stained with Masson's trichrome and Hematoxylin-Eosin-Safran and examined with a light microscope. A 0 to 3 scoring system was used to quantify the severity of LA structural abnormalities. LA von Willebrand factor (vWF) content was also assessed using immunohistochemical staining. RESULTS: In six of the eight SHRs, LA fibrosis, inflammatory infiltrates, and myocyte necrosis of varying grades of severity were observed. The most frequent feature was endocardial fibrosis, which was observed in six SHRs and in none of the WKY rats. Intra-atrial thrombosis was found in three SHRs and in none of the WKY rats. The intensity of vWF-related fluorescence was higher in the atrial endocardium of SHRs compared to age-matched WKY rats. CONCLUSIONS: Our findings reinforce the role of LA structural abnormalities in atrial arrhythmogenicity. However, two SHRs did not present LA histological abnormalities despite the presence of arrhythmias. This finding suggests that the LA remodeling-atrial tachyarrhythmia relationship could be highly nonlinear and that atrial fibrosis is more likely to be a facilitator of atrial arrhythmogenicity, rather than a prerequisite. We also provide evidence that intra-atrial thrombosis accompanies LA structural remodeling in arrhythmic rats. Increased endocardial platelet adhesion molecule vWF could contribute to this increased thrombogenicity. (+info)Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation. (7/11)
(+info)Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing. (8/11)
(+info)
heart - Intra-atrial thrombosis epidemiology - Medical Sciences Stack Exchange
Localization of atrial natriuretic peptide in normal human atrial tissue by immunoelectron microscopy<...
Apnoea-associated intrathoracic pressure swings create a dynamic arrhythmogenic atrial substrate during sleep: authors reply ...
Terumo Granted CE Mark for Renal Sympathetic Denervation System
ENDOCARDIAL FIBROSIS | Heart
REnal SympathetiC Denervation to sUpprEss Tachyarrhythmias in ICD Recipients - Full Text View - ClinicalTrials.gov
REnal SympathetiC Denervation to sUpprEss Tachyarrhythmias in ICD Recipients - Full Text View - ClinicalTrials.gov
Acufinder.com - Ren 09 (CO 9)
Measurement of funny current (I(f)) channel mRNA in human atrial tissue: Correlation with left atrial filling pressure and...
Plot velocity vectors - MATLAB feather
Calories in Microwave Peanut Brittle - Calorie, Fat, Carb, Fiber, and Protein Info | SparkRecipes
Endokardfibrosen: Klinik, Therapie, Pathologie. | Annals of Internal Medicine | American College of Physicians
Doppler flow measurement using surface integration of velocity vectors (SIVV) : in vitro validation.
US5310562A - Composition and method for reparation and prevention of fibrotic lesions - Google Patents
Help with work and vector forces | Physics Forums - The Fusion of Science and Community
Renal Sympathetic Denervation | Medical Microwave Ablation Technology and Devices | Symple Surgical Inc., (SSI) | Northern...
Assessment of brachial artery mechanics using velocity vector imaging does not predict arteriovenous fistula failure; A...
Velocity and Acceleration of a particle around a circle | Physics Forums - The Fusion of Science and Community
Patent US5120322 - Method and apparatus for treatment of fibrotic lesions - Google Patents
Scientific Program
Carbon Dioxide And Kidney Disease 2019 • Kidney Treatment
Keloid Symptoms, Causes and Elimination of Keloid Scars
6-04 msk/derm/vasc Flashcards - Cram.com
Identification of discrete surfaces. A: whole cardiac m | Open-i
Severe Renal Artery Stenosis After Renal Sympathetic Denervation | JACC: Cardiovascular Interventions
The Role of Fibroblasts in Complex Fractionated Electrograms During Persistent/Permanent Atrial Fibrillation | Circulation...
Clinical manifestations and diagnosis of coarctation of the aorta
Telocyte
Mandache, E.; Gherghiceanu, M.; Macarie, C.; Kostin, S.; Popescu, L. M. (December 2010). "Telocytes in human isolated atrial ... tissue homoeostasis and remodelling/renewal. Figure 9. Human mammary gland stroma: TEM; original magnification 9,100x. A: ... amyloidosis: ultrastructural remodelling". Journal of Cellular and Molecular Medicine. 14 (12): 2739-2747. doi:10.1111/j.1582- ...
Ventricular remodeling
However, atrial natriuretic peptide is thought to be cardio-protective. Remodeling of the heart is evaluated by performing an ... Physiological remodeling is reversible while pathological remodeling is mostly irreversible. Remodeling of the ventricles under ... In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of ... This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling ...
Sarcolipin
"Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling". The Journal of ... Ablation of sarcolipin increases atrial Ca2+ transient amplitudes and enhanced atrial contractility. Furthermore, atria from ... "Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility". Proceedings of the National ...
MIRN21
October 2012). "Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction ... November 2010). "Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice". The Journal of Clinical ...
Atrial natriuretic peptide
ANP also acts in the heart to prevent cardiac hypertrophy and to regulate vascular remodeling and energy metabolism. NPPA ... Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac ... These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood ... ANP is secreted in response to: Stretching of the atrial wall, via Atrial volume receptors Increased Sympathetic stimulation of ...
Atrial fibrillation
The atrial remodeling that includes the pathologic changes described above has been referred to as atrial myopathy. There are ... which leads to atrial remodeling and fibrosis, with loss of atrial muscle mass. This process occurs gradually, and experimental ... left atrial volume, size, and left ventricular hypertrophy, characteristic of chronic hypertension. All atrial remodeling is ... This form of atrial fibrillation occurs in people of all ages but is most common in the elderly, in those with other atrial ...
XEN-D0101
... selectively increases atrial refractory period by 22% in dogs with atrial tachycardia induced electrical remodeling. ... During atrial fibrillation this process becomes chaotic and the atrial depolarization occurs faster than it should causing the ... A recognized atrial selective drug target is Kv1.5, which is found in atria but not in ventricles. Kv1.5 carries the ultra ... Atrial fibrillation (AF) is an arrhythmia that occurs in 1-2% of the general population. AF is linked to several cardiac causes ...
Left atrial volume
5-Diiodothyronine and Correlates with Atrial Remodeling". European thyroid journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ... It is usually calculated as left atrial volume index in terms of body surface area. The left atrial volume is commonly measured ... "Left Atrial Volume Index Is Associated With Cardioembolic Stroke and Atrial Fibrillation Detection After Embolic Stroke of ... The resulting index is referred to as left atrial volume index (LAVI): L A V I = A L B S A {\displaystyle LAVI={\frac {{A}_{L ...
3,5-Diiodothyronine
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ...
Euthyroid sick syndrome
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ...
Sum activity of peripheral deiodinases
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ... Probably as a consequence of non-thyroidal illness syndrome, SPINA-GD predicts mortality in trauma and postoperative atrial ... Correlations were also shown to age, total atrial conduction time, and concentrations of 3,5-diiodothyronine and B-type ...
Mir-590 microRNA precursor family
... of miR-590 by nicotine has been found to play a key part in the generation of atrial fibrosis by atrial structural remodelling ... "Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovascular Research. ...
Mir-133 microRNA precursor family
"Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovasc. Res. 83 (3): ... Torella D (2011). "MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo ...
MYL7
"Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs". ... In a porcine model of left atrial remodeling following mitral regurgitation, VLC-2 was shown to be upregulated. Human ALC-2 is ... Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans ... In a canine model of atrial fibrillation, decreased atrial contractility was associated with decreased ALC-2 and myosin binding ...
Ameca, Jalisco
The recently remodeled atrium looks better than ever with its new and spacious gardens that are home to different types of ... Its pink stone facade has a tower composed of three bodies; there are cross atrial figures of the Passion of the Christ and of ...
Endothelin 2
A study showed a significant association of a specific polymorphism of the EDN2 gene with increased incidence of atrial ... Overall, the evidence suggests that ET-2 could modulate vascular tone, tissue morphology and remodelling. Since reports of ... December 2007). "A985G polymorphism of the endothelin-2 gene and atrial fibrillation in patients with hypertrophic ...
PCSK6
In vascular remodeling, Pcsk6 was found to induce smooth muscle cell migration in response to PDGFB by activating MMP14. When ... Pcsk6 KO mice was shown to develop salt-sensitive hypertension due to failure of pro-corin activation crucial to atrial ... "PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling". Circulation Research. 126 (5): ...
Management of heart failure
It is also believed that angiotensin directly affects cardiac remodeling, and blocking its activity can thereby slow the ... Glucocorticoids induce a potent diuresis in heart failure because they could improve renal responsiveness to atrial natriuretic ... It is also thought that catecholamines and other sympathomimetics have an effect on cardiac remodeling, and blocking their ... These commonly involve surgical left ventricular remodeling. The aim of the procedures is to reduce the ventricle diameter ( ...
MMP9
For example, MMP9 appears to be involved in the remodeling associated with malignant glioma neovascularization. It is also a ... MMP9 levels increase with the progression of idiopathic atrial fibrillation. MMP9 has been found to be associated with the ... Gelatinase B plays a central role in tumor progression, from angiogenesis, to stromal remodeling, and ultimately metastasis. ... which are key effectors of ECM remodeling. MMP9, along with elastase, appears to be a regulatory factor in neutrophil migration ...
Roberta Gottlieb
Intermittent use of a short-course glucagon-like peptide-1 receptor agonist therapy limits adverse cardiac remodeling via ... Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass. JCI ... "Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypass". JCI ...
Catheter ablation
One reason for this may be that once the heart has undergone atrial remodeling as in the case of chronic atrial fibrillation ... AF therefore have an increased chance of success with an ablation since their heart has not undergone atrial remodeling yet.[ ... After 12 months, participants receiving catheter ablation were more likely to be free of atrial fibrillation, and less likely ... Keane, D; Ruskin, J (Fall 2002). "Pulmonary vein isolation for atrial fibrillation". Rev Cardiovasc Med. 3 (4): 167-175. PMID ...
Cardiac skeleton
This is why atrial fibrillation almost never degrades to ventricular fibrillation. In youth, this collagen structure is free of ... Throughout life, the cardiac collagen skeleton is remodeled. Where collagen is diminished by age, calcium is often deposited, ... The AV node is the only electrical conduit from the atria to the ventricles through the cardiac skeleton, which is why atrial ...
CORIN
... , also called atrial natriuretic peptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene. ... Corin-mediated ANP production in the pregnant uterus promotes spiral artery remodeling and trophoblast invasion. CORIN ... Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt- ... Wu F, Yan W, Pan J, Morser J, Wu Q (May 2002). "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes". The ...
Efonidipine
Working on sino atrial node cells by inhibiting T-type calcium channel activation, Efonidipine prolongs the late phase-4 ... By reducing synthesis and secretion of aldosterone, Efonidipine prevents hypertrophy and remodeling of cardiac myocytes. ... depolarization of the sino atrial node action potential and suppresses an elevated HR. The negative chronotropic effect of ...
Hypertensive heart disease
"2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial ... Left ventricular hypertrophy and left ventricular remodeling Diminished coronary flow reserve and silent myocardial ischemia ... often termed diastolic heart failure Atrial fibrillation, other cardiac arrhythmias, or sudden cardiac death Heart failure can ... hypertrophy in athletes Congestive heart failure or heart failure with normal ejection fraction due to other causes Atrial ...
Endocardial cushions
These thickenings will go on to fuse and remodel to eventually form the valves and septa of the mature adult heart. A problem ... Upon sectioning of the heart the atrioventricular endocardial cushions can be observed in the lumen of the atrial canal as two ... As heart development continues, this tube undergoes remodeling to eventually form the four-chambered heart. The endocardial ... in endocardial cushion development or remodeling is thought to be associated with atrioventricular septal defect. Endocardial ...
Budiodarone
This suggests that budiodarone may promote atrial re-modelling to improve malfunctioning ion channels that once potentiated ... In addition to reductions in atrial fibrillation burden, similar dose-dependent reductions in the number of atrial fibrillation ... "Amiodarone to prevent recurrence of atrial fibrillation. Canadian Trial of Atrial Fibrillation Investigators". The New England ... in patients with paroxysmal atrial fibrillation and pacemakers with atrial fibrillation data logging capabilities. Heart Rhythm ...
Sinus node dysfunction
Other intrinsic causes include inherited ion channel dysfunctions, remodeling diseases such as heart failure and atrial ... or remodeling of the sinus node while extrinsic causes can create or worsen underlying atrial arrhythmias. Intrinsic causes ... or tachycardia-bradycardia syndrome presenting as various atrial arrhythmias such as atrial fibrillation, flutter, tachycardia ... Drago F, Silvetti MS, Grutter G, De Santis A (1 July 2006). "Long term management of atrial arrhythmias in young patients with ...
Right bundle branch block
... congenital heart disease such as atrial septal defect, and ischemic heart disease. In addition, a right bundle branch block may ... Causes for incomplete right bundle branch block are exercise-induced right ventricular remodeling, increased RV free wall ...
T-tubule
Heart failure can also cause the near-complete loss of T-tubules from atrial cardiomyocytes, reducing atrial contractility and ... However, disordered T-tubule structure may not be permanent, as some suggest that T-tubule remodelling might be reversed ... They are found in ventricular muscle cells in most species, and in atrial muscle cells from large mammals. In cardiac muscle ... T-tubules are found in both atrial and ventricular cardiac muscle cells (cardiomyocytes), in which they develop in the first ...
Johann Bauersachs
Hannover Medical School Department of Cardiology and Angiology Interview about Atrial fibrillation (ARD 4.11. 2014, German ... left ventricular repair and remodelling following ischemia, and acute and chronic heart failure. Prof. Dr. Johann Bauersachs ...
Periodontal disease
Harada, Masahide; Van Wagoner, David R.; Nattel, Stanley (2015). "Role of Inflammation in Atrial Fibrillation Pathophysiology ... stimulating fibroblast proliferation and metalloproteinases activation favouring cardiac remodelling. Periodontal disease is ... IL-6 and IL-8 can lead to progression of atherosclerosis and the development and perpetuation of atrial fibrillation, as it is ...
Third-degree atrioventricular block
Pacemakers in this role are usually programmed to enforce a minimum heart rate and to record instances of atrial flutter and ... heart failure leads to prolongation of the PR interval and atrioventricular Junction enlargement and ion channel remodelling in ... As with other forms of heart block, secondary prevention may also include medicines to control blood pressure and atrial ... atrial fibrillation, two common secondary conditions that can accompany third-degree AV block. Since pacemaker correction of ...
Glucocorticoid
Liu C, Chen Y, Kang Y, Ni Z, Xiu H, Guan J, Liu K (Oct 2011). "Glucocorticoids improve renal responsiveness to atrial ... In addition, glucocorticoids are necessary for normal brain development, by initiating terminal maturation, remodeling axons ... to assist in the normalization of extracellular fluid volume by regulating body's action to atrial natriuretic peptide (ANP). ...
Exercise-induced pulmonary hemorrhage
Regional veno-occlusive remodeling, especially within the caudodorsal lung fields, contributes to the pathogenesis of EIPH, ... atrial fibrillation, or guttural pouch mycoses. EIPH reduces a horse's racing performance. Severe EIPH (epistaxis) shortens a ... Other histopathologic findings include fibrosis, bronchial artery neovascularization, venous remodeling, bronchiolitis, ... and remodelling components. The primary mechanism is likely to be high pulmonary vascular pressures with concurrent negative ...
List of MeSH codes (G09)
... atrial function MeSH G09.330.582.075.100 - atrial function, left MeSH G09.330.582.075.200 - atrial function, right MeSH G09.330 ... ventricular remodeling MeSH G09.772.765.060 - airway resistance MeSH G09.772.765.540 - lung compliance MeSH G09.772.765.600 - ...
Cardiac rhythm problems during spaceflight
Third, there is evidence of cardiac remodeling after long-duration flight as seen in Figure 5. Fourth, there are medications ... One crewmember during Apollo 15 experienced a 22-beat nodal bigeminal rhythm, which was followed by premature atrial beats. ... The investigators observed no change in the number of premature ventricular contractions of premature atrial contractions per ... Other heart rhythm problems, such as atrial fibrillation, can develop over time, necessitating periodic screening of ...
Dilated cardiomyopathy
The electrocardiogram often shows sinus tachycardia or atrial fibrillation, ventricular arrhythmias, left atrial enlargement, ... Pieske B (2004). "Reverse remodeling in heart failure - fact or fiction?". Eur Heart J Suppl. 6: D66-78. doi:10.1016/j.ehjsup. ... As a result, those with DCM are at increased risk of atrial fibrillation. Furthermore, stroke volume is decreased and a greater ... The concept of cardiac remodeling was initially developed to describe changes that occur in the days and months following ...
Christine P. Hendon
Since this remodelling results in shortening of the cervix, which is thought to result in preterm birth, Hendon sought to ... Since the composition of atrial tissue impacts disease pathology, diagnosis, and recovery, Hendon and her team developed an ... Hendon first found that collagen fiber dispersion and directionality had an impact on cervical remodelling and thus propensity ... Hendon helped to improve and guide ablation treatment of atrial fibrillation using a near-infrared spectroscopy (NIRS) guided ...
Graves' disease
Tan NY, Leong YY, Lang SS, Htoon ZM, Young SM, Sundar G (May 2017). "Radiologic Parameters of Orbital Bone Remodeling in ... George H. W. Bush, former U.S. president, developed new atrial fibrillation and was diagnosed in 1991 with hyperthyroidism due ... atrial fibrillation), which may lead to stroke. If the eyes are proptotic (bulging) enough that the lids do not close ... and progressive remodeling of the orbital walls. Other distinctive features of TAO include lid retraction, restrictive myopathy ...
Antiarrhythmic agent
"treatment of paroxysmal atrial fibrillation - General Practice Notebook". www.gpnotebook.co.uk. "protocol for management of ... molecules underlying longer term signalling processes affecting structural remodeling. It also allows for multiple drug targets ... With regard to management of atrial fibrillation, classes I and III are used in rhythm control as medical cardioversion agents ... results in slowed atrial-ventricular myocyte repolarization. Class III agents have the potential to prolong the QT interval of ...
Collateralization
... though structural remodeling continues by cell proliferation and synthesis of elastin and collagen over a period of up to six ... and atrial blood pressure, redirect ST elevation into less serious ST depression in ischemia, and prevent infarction and ... "Following an arterial occlusion outward remodeling of pre-existent inter-connecting arterioles occurs by proliferation of ...
Osteoporosis
In normal bone, matrix remodeling of bone is constant; up to 10% of all bone mass may be undergoing remodeling at any point in ... results from the National Registry of Atrial Fibrillation 2". Arch. Intern. Med. 166 (2): 241-246. doi:10.1001/archinte.166.2. ... so the intense remodeling causes these areas to degenerate most when the remodeling is imbalanced.[citation needed] Around the ... Bone Remodeling Dynamics. Springfield, IL: 1963. Wu S, Liu Y, Zhang L, Han Y, Lin Y, Deng HW (2013). "Genome-wide approaches ...
Pathophysiology of heart failure
... causing structural remodelling of the heart over the long term. Many of these remodelling effects seem to be mediated by ... early-to-atrial left ventricular filling ratio), the E (early left ventricular filling) deceleration time, and the isovolumic ... May 2007). "Angiotensin II type 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in ... or by pathological tachyarrhythmias such as atrial fibrillation with rapid ventricular response) may result in flash pulmonary ...
Heart failure with preserved ejection fraction
Atrial contraction is responsible for around 20% of the total filling blood volume. (In atrial fibrillation, this additional 20 ... Dilated ("remodeled") hearts have increased volume relative to the amount of diastolic pressure, and therefore have increased ( ... Left atrial and pulmonary venous pressure increases in HFpEF due to diastolic insufficiency thus increasing pulmonary artery ... First, ventricles are filled by a pressure gradient but near the end, atria contract (atrial kick) and force more blood to pass ...
Blood pressure
In the longer term a process termed remodeling also contributes to changing the caliber of small blood vessels and influencing ... Variants of venous pressure include: Central venous pressure, which is a good approximation of right atrial pressure, which is ... Tkachenko BI, Evlakhov VI, Poyasov IZ (2002). "Independence of changes in right atrial pressure and central venous pressure". ... Mulvany, Michael J. (2012). "Small artery remodelling in hypertension". Basic & Clinical Pharmacology & Toxicology. 110 (1): 49 ...
Cardiac contractility modulation
In atrial fibrillation, electrical activity in the atrium is severely disturbed and is therefore not a reliable basis for the ... Dec 2009). "Impact of cardiac contractility modulation on left ventricular global and regional function and remodeling". JACC ... This also applies to other diseases involving severe disturbance in electrical atrial sensing. Requests have been raised in ... first experience in heart failure patients with reduced ejection fraction and permanent atrial fibrillation". Europace. 16 (8 ...
Divya Nag
... for the Apple Heart Study InvestigatorsLarge-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation. N Engl J Med ... Cardiac Remodeling, Translational Therapies and Imaging Techniques, Molecular and Translational Medicine, Humana Press, pp. 485 ... "Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation". New England Journal of Medicine. 381 (20): 1909-1917. ...
TRPC
In addition, TRPC3 is upregulated in the atria of patients with atrial fibrillation (AF). TRPC3 regulates angiotensin II- ... cardiac growth and remodelling of the heart. TRPC channel's involvement in well studied signaling pathways and significance in ... contributing to pathological remodelling of the heart. TRPC1 channels are activated by receptors coupled to phospholipase C ( ...
Frontiers | Heart Rhythm Insights Into Structural Remodeling in Atrial Tissue: Timed Automata Approach
... fitting method used in the design of the hybrid automaton cycle follows the well-recognized physiological phases of the atrial ... fitting method used in design of the hybrid automaton cycle follows the physiologically well recognized phases of the atrial ... Nattel, S., Burstein, B., and Dobrev, D. (2008). Atrial remodeling and atrial fibrillation. Circulation 1, 62-73. doi: 10.1161/ ... Heart Rhythm Insights Into Structural Remodeling in Atrial Tissue: Timed Automata Approach. Danuta Makowiec1*, Joanna Wdowczyk2 ...
Dropbox - 2019 Inhibition of soluble TNFα prevents adverse atrial remodeling and atrial arrhythmia susceptibility induced in...
Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation...
T1 - Reappraisal of Atrial fibrillation. T2 - interaction between hyperCoagulability, Electrical remodelling and Vascular ... title = "Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular ... Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation ... Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation ...
Elevated plasma Ninjurin-1 levels in atrial fibrillation is associated with atrial remodeling and thromboembolic risk | BMC...
However, the role of plasma Ninj1 in atrial fibrillation (AF) has not been reported. The present study aimed to investigate the ... Also, the clinical characteristics, left atrial volume index (LAVI), CHA2DS2-VASc score, and HAS-BLED score were evaluated. ... associated with left atrial enlargement and thromboembolic risk in AF. ... Elevated plasma Ninjurin-1 levels in atrial fibrillation is associated with atrial remodeling and thromboembolic risk Doc Wire ...
Long-Term Results after Percutaneous Closure of Atrial Septal Defect: Cardiac Remodeling and Quality of Life
... Mangiafico S; ... Background: Atrial septal defect (ASD) represents a common congenital heart malformation, cause of right ventricle (RV) volume ... Background: Atrial septal defect (ASD) represents a common congenital heart malformation, cause of right ventricle (RV) volume ... Conclusions: Our data showed a great improvement in symptoms and positive cardiac remodeling after closure of ASD, more ...
Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the...
Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the ... Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the ... Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation : Data from the ... Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation : Data from the ...
ESC 365 - Left atrial remodelling after septal myectomy is associated with a reduced 5-year risk of atrial fibrillation in...
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation. | Clin Sci (Lond);136...
Fibrilação Atrial; Remodelamento Atrial; Masculino; Camundongos; Animais; Fibrilação Atrial/tratamento farmacológico; ... Atrial remodeling due to fibrosis and abnormal intracellular Ca2+ activities contributes to initiation and persistence of ... Fibrilação Atrial / Remodelamento Atrial Limite: Animais Idioma: Inglês Revista: Clin Sci (Lond) Ano de publicação: 2022 Tipo ... Fibrilação Atrial / Remodelamento Atrial Limite: Animais Idioma: Inglês Revista: Clin Sci (Lond) Ano de publicação: 2022 Tipo ...
Time Course of Ventricular Remodeling after Atrial Septal Defect Closure in Adult Patients - Congenital Heart International...
Time Course of Ventricular Remodeling after Atrial Septal Defect Closure in Adult Patients. ... Time Course of Ventricular Remodeling after Atrial Septal Defect Closure in Adult Patients. ... In light of this, cardiac chamber remodeling may be an important determinant of long-term outcomes. This is a single center ... Blanche Cupido (Cape Town, South Africa), section editor of ACHD Journal Watch: Atrial septal defects represent the most common ...
Atrial Fibrillation: Practice Essentials, Background, Pathophysiology
Atrial fibrillation (AF) has strong associations with other cardiovascular diseases, such as heart failure, coronary artery ... 5] Electrical remodeling is a consequence of high atrial rates and includes shortening of the refractory period of atrial ... and mass of atrial tissue. Increased atrial mass, shortened atrial refractory period, and delayed intra-atrial conduction ... Increased intra-atrial pressure results in atrial electrical and structural remodeling and predisposes to AF. The most common ...
Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure with Preserved Ejection Fraction<...
Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure with Preserved Ejection Fraction. ... Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure with Preserved Ejection Fraction ... Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure with Preserved Ejection Fraction ... Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure with Preserved Ejection Fraction ...
Atrial Fibrillation: Practice Essentials, Background, Pathophysiology
Atrial fibrillation (AF) has strong associations with other cardiovascular diseases, such as heart failure, coronary artery ... 5] Electrical remodeling is a consequence of high atrial rates and includes shortening of the refractory period of atrial ... and mass of atrial tissue. Increased atrial mass, shortened atrial refractory period, and delayed intra-atrial conduction ... Increased intra-atrial pressure results in atrial electrical and structural remodeling and predisposes to AF. The most common ...
Impact of Genotype on the Occurrence of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy - American Journal of...
Left atrial remodeling in hypertrophic cardiomyopathy and susceptibility markers for atrial fibrillation identified by ... Efficacy of catheter ablation for atrial fibrillation in hypertrophic cardiomyopathy: impact of age, atrial remodelling, and ... Effects of chronic atrial fibrillation on active and passive force generation in human atrial myofibrils. ... Ranolazine in the treatment of atrial fibrillation: results of the dose-ranging RAFFAELLO (Ranolazine in Atrial Fibrillation ...
P wave detection and delineation in the ECG based on the phase free stationary wavelet transform and using intracardiac atrial...
The early prognosis of cardiac afflictions such as atrial fibrillation and the response of a patient to a given treatment is ... Electrical remodeling in atrial fibrillation time course and mechanisms. Circulation 1996; 94: 2968-2974.10.1161/01.CIR.94.11. ... P-wave morphology during right atrial pacing before and after atrial flutter ablation - a new marker for success. Am J Cardiol ... P wave morphology in guiding the ablation strategy of focal atrial tachycardias and atrial flutter. Curr Cardiol Rev 2015: 103- ...
Targeted pharmacological reversal of electrical remodeling after cardioversion--rationale and design of the Flecainide Short...
Persistent atrial fibrillation (AF) causes relevant mortality and cardiovascular and noncardiovascular morbidity. Therefore, ... the atrial action potential can assist in the prevention of recurrent AF by promoting the reversal of electrical remodeling. ... "electrical remodeling" and "structural remodeling"). Underlying disease processes and parts of structural remodeling are not ... Electrical remodeling, in contrast, is reversed by a few weeks of maintenance of sinus rhythm under experimental conditions. ...
JCM | August-1 2021 - Browse Articles
Left Atrial Remodeling and Brain Natriuretic Peptide Levels Variation after Left Atrial Appendage Occlusion by Thibaut Pommier ... variation and left atrial remodeling after the left atrial appendage occlusion (LAAO) technique. Methods: Prospective study ... variation and left atrial remodeling after the left atrial appendage occlusion (LAAO) technique. Methods: Prospective study ... Reverse atrial remodeling (RAR) at 6 weeks was observed in six patients (14%). Despite no difference in BNP levels on admission ...
Aortic Root Remodelling, Debranching of Arch, Ascending Aorta Replacement (Lupiae) and CABGX3 Prior TEVAR for Type B Aortic...
Attach atrial and ventricular epicardial pacing wires.. Debranch the aortic arch and anastomosis with the Lupiae prosthesis. ... Remodeling the aortic root and preservation of the native aortic valve. Oper Tech Card Thorac Surg. 1996;1(1):44-56. ... Aortic Root Remodelling, Debranching of Arch, Ascending Aorta Replacement (Lupiae) and CABGX3 Prior TEVAR for Type B Aortic ... See the final image of debranching of the aortic arch, resuspension of the aortic valve, aortic root remodelling, replacement ...
Clinical Research - American Medical Women's Association
Sex Differences in Stroke Risk with Atrial Fibrillation. May 9, 2012. Sex Differences in Stroke Risk Among Older Patients With ... Female sex and estrogens influence cardiac remodeling and fibrosis in animal models and in men. Women adapt to pressure ... Sex Differences in Stroke Risk with Atrial Fibrillation. May 9, 2012. Sex Differences in Stroke Risk Among Older Patients With ... PhD Stroke is a serious complication associated with atrial fibrillation (AF). Women with AF are at higher risk of stroke ...
Manabu Kikuta - Articles - Scientific Research Publishing
Biatrial enlargement as a predictor for reablation of atrial fibrillation
Since left atrium remodeling was associated with atrial fibrillation and increased atrial volume, interstitial fibrosis, and ... Right atrial diameter and outcome of catheter ablation of atrial fibrillation. J Interv Card Electrophysiol. 2017;49(2):157-164 ... Progression of atrial fibrillation after a failed initial ablation procedure in patients with paroxysmal atrial fibrillation. ... Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: The ...
TOAST Subtypes of Ischemic Stroke and Its Risk Factors: A Hospital-Based Study at Cipto Mangunkusumo Hospital, Indonesia
... was the only variable that was related to SVD while in CE it was atrial fibrillation (OR 113,5; 95% CI 13,6-946,5).,i, ... while in CE subtypes was atrial fibrillation (60%;p<0,001). In multivariate analyses, hypertension (OR 3; 95% CI ... In addition, the risk of thromboembolism increases as atrial cardiopathy worsens due to structural remodeling of the atrium [37 ... Atrial fibrillation had significant association in cardioembolic subtype with p,0,001. However, the wide CI 95% of atrial ...
The Risk of Atrial Fibrillation Increases with Earlier Onset of Obesity: A Mendelian Randomization Study
Electrophysiological, Electroanatomical, and Structural Remodeling of the Atria as Consequences of Sustained Obesity. J Am Coll ... Levels of and Changes in Childhood Body Mass Index in Relation to Risk of Atrial Fibrillation and Atrial Flutter in Adulthood. ... Validation of Single Centre Pre-Mobile Atrial Fibrillation Apps for Continuous Monitoring of Atrial Fibrillation in a Real- ... Left atrial epicardial adiposity and atrial fibrillation. Circ Arrhythm Electrophysiol. 2010;3:230-6 ...
Find Research outputs
- The University of Aberdeen Research Portal
Table of Contents page: International Journal of Cardiology
Patients with persistent atrial fibrillation have electrically but not functionally remodeled atria even after sustained sinus ... Atrial signal characteristics during sinus rhythm differentiate subclasses of lone paroxysmal atrial fibrillation. *Raija ... A prospective, multicentre clinical trial to evaluate the BioSTAR bioabsorbable septal repair implant for the closure of atrial ... Feasibility of corticosteroid in the prevention of atrial fibrillation after cardiac surgery: A prospective, double-blind ...
Sulfide regulation of cardiovascular function in health and disease | Nature Reviews Cardiology
Decreased bioavailability of hydrogen sulfide links vascular endothelium and atrial remodeling in atrial fibrillation. Redox ... Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the ... Moreover, in the same study, 24-h rapid atrial pacing in a beagle model of atrial fibrillation (AF) increased atrial ... increases atrial superoxide levels and the frequency of atrial cell calcium sparks, slows atrial conduction velocity and ...
ROB S MACLEOD - Research - Faculty Profile - The University of Utah
Atrial Fibrillation Ablation Outcome Is Predicted by Left Atrial Remodeling on MRI. Circ A & E, Feb 1;7(1):23-30, 2014. ... Left Atrial Structural Remodeling Using DE-MRI Independently Predicts Strokes in Patients with Atrial Fibrillation. In Heart ... Left Atrial Struc- tural Remodeling Utilizing DE-MRI Predicts Early Recurrence of Atrial Fibrillation Follow- ing Ablation ... Left Atrial Wall Thickness and Its Relationship to Structural Remodeling and Recurrence Following Atrial Fibrillation Ablation ...
C-type Natriuretic Peptide Ameliorates Monocrotaline-induced Pulmonary Hypertension in Rats | American Journal of Respiratory...
... has been shown to act as a local regulator of vascular tone and remodeling. We investigated whether CNP ameliorates ... To investigate the acute hemodynamic effects of CNP and atrial natriuretic peptide, CNP (0.05 μg/kg/min) or atrial natriuretic ... C-type natriuretic peptide (CNP) has been shown to act as a local regulator of vascular tone and remodeling. We investigated ... Infusion of atrial natriuretic peptide significantly decreased RV systolic pressure and mean arterial pressure (Figure 6). ...
Tricuspid valve regurgitation: no longer the "forgotten valve"
... with more annular dilation and right atrial remodelling. Most frequently, this latter form of RV remodelling occurs in elderly ... From the apical four-chamber view, right atrial short-axis and long-axis dimensions can be assessed and the right atrial area ... In invasive testing, ventricularisation of the right atrial pressure tracing, in which the contour of the right atrial pressure ... Right atrial pressure can be estimated by measuring the inferior vena cava dimensions and respiratory variation in the ...
What Happens During Atrial Fibrillation? - Journalist PRO
Nevertheless, it is the cardiac remodeling that accounts for most of the mechanisms. Cardiac remodeling, specifically of atria ... Mechanisms Of Atrial Fibrillation Development. Besides, there are a wide variety of pathophysiological mechanisms of atrial ... About 15 to 20 percent of people who have strokes have atrial fibrillation. This clot risk is why patients with atrial ... On the other hand, atrial fibrillation might also come and go, which is what is called paroxysmal atrial fibrillation, however ...
Short-term melatonin supplementation decreases oxidative stress but does not affect left ventricular structure and function in...
Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs. Biochem Biophys Res ... AO was measured at the level of the aortic valve, whereas LA was measured in the left atrial dimension. Then the left atrial to ... Table 4 Cardiac function and left atrial size from Motion (M)-mode parameters of myxomatous mitral valve degenerative dogs pre ... Additionally, cardiac remodeling responds to many pathological factors [36,37,38]. Volume overload can cause cardiac wall ...
Undergoing atrial fibrillationAblationStructuralFibrosisRisk of atrial fibrillationDevelopment of atrial fibrillationVentricular RemodelingArrhythmiaAdverse atrialPatientsPersistentSeptal defectTissueParoxysmalPulmonaryEchocardiographicHypertrophic cardiomyopathyMyocardial infarctionMyocardiumFlutterSusceptibilityAtriumProgressionCardioversionTherapeuticSinus rhythmStrokeEchocardiographyDilationHypertensionVascularMicroRNAMitralThrombusChambers of the heartEnlargementRefractoryAntiarrhythmicSymptomsOccurrenceMethodsCoronaryPredictiveRight ventricle
Undergoing atrial fibrillation1
- The image on the right is a reconstructed 3-dimensional image of the right atrium in a patient undergoing atrial fibrillation ablation. (medscape.com)
Ablation12
- It represents the endocardial shell of the right atrium and is used as the template during left atrial ablation procedures. (medscape.com)
- We aimed to determine whether biatrial enlargement could predict reablation of atrial fibrillation after first ablation. (medsci.org)
- 519 consecutive patients with drug resistant atrial fibrillation [paroxysmal AF (PAF) 361, non-PAF 158] who underwent catheter ablation in Capital Medical University Xuanwu hospital between 2009 and 2014 were enrolled. (medsci.org)
- Anti-arrhythmic drugs or cardioversion were used to control the recurred atrial arrhythmia in patients with recurrence of atrial fibrillation after ablation. (medsci.org)
- Biatrial enlargement is an independent risk predictor for the reablation in atrial fibrillation patients after first ablation. (medsci.org)
- Risk factors have been identified to predict the recurrence of atrial fibrillation after ablation, such as left atrial enlargement (LAE), right atrium diameter (RAD), atrial tissue fibrosis, and low-voltage areas detected by high-density electroanatomical mapping in left atrium ( 7 , 8 , 9 , 10 , 11 ). (medsci.org)
- Blanking period after radiofrequency ablation for atrial fibrillation guided by ablation lesion maturation based on serial MR imaging. (utah.edu)
- Effective Ablation Settings That Predict Chronic Scar After Left Atrial Ablation. (utah.edu)
- He has pioneered a new circumferential ultrasound vein-ablation system to correct atrial fibrillation and performed the procedure on the world's first five patients. (jafib.com)
- Journal of Cardiovascular Electrophysiology , Heparin reversal with protamine sulfate is not required in atrial fibrillation ablation with suture hemostasis. (creighton.edu)
- Safety and Feasibility of RF Ablation for Atrial Fibrillation after Amulet Implantation and Device Electrical Characteristics. (creighton.edu)
- Protamine Reversal for Heparin is not Required Following Figure of Eight Stopcock Hemostasis after Atrial Fibrillation Ablation. (creighton.edu)
Structural11
- Structural modifications of the atrial tissue, caused by heart diseases and/or the normal aging process, influence the performance of the heart contraction. (frontiersin.org)
- Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation. (bvsalud.org)
- The cause of these type of afflictions is often a structural remodeling of the heart tissue and the electrophysiological properties of the atria [10]. (degruyter.com)
- Underlying disease processes and parts of structural remodeling are not always reversible. (nih.gov)
- Whereas primary/organic TR (caused by a structural abnormality) is relatively infrequent, secondary or functional TR (caused by dilatation of the tricuspid annulus and remodelling of the right ventricle and right atrium) is the predominant cause, and isolated TR, associated with atrial fibrillation, is an emerging entity. (escardio.org)
- Cardiac remodeling, specifically of atria, eventually results in electrical and structural changes in the heart that may lead to deranged rhythm in atrial fibrillation. (journalist-pro.com)
- The aim of this study was to determine the echocardiographic parameters associated with LA asymmetric structural remodeling (ASR) in patients with and without nonvalvular atrial fibrillation (AF). (jafib.com)
- Symmetric structural remodeling (SSR) was defined as all other cases. (jafib.com)
- Conclusion LA dilation is associated with asymmetrical structural remodeling. (jafib.com)
- 3. Sustained long-term endurance training produces a substrate for AF maintenance by a combination of structural and autonomic remodeling. (icm-mhi.org)
- Archives of the Turkish Society of Cardiology , Akkaya M, Marrouche N, Higuchi K, Koopmann M, Damal K, Kholmovski E, McGann C. The Degree of Left Atrial Structural Remodeling Impacts Left Ventricular Ejection Fraction in Patients with Atrial Fibrillation. (creighton.edu)
Fibrosis4
- Atrial remodeling due to fibrosis and abnormal intracellular Ca2+ activities contributes to initiation and persistence of atrial fibrillation (AF). (bvsalud.org)
- Furthermore, isorhamnetin strongly attenuated AngII-induced left atrial enlargement and atrial fibrosis . (bvsalud.org)
- Regions of High Dominant Frequency in Chronic Atrial Fibrillation Anchored to Areas of Atrial Fibrosis. (utah.edu)
- These factors include oxidative stress, systemic inflammation, autonomic imbalance, endocrine disorders, early electrical remodeling, such as shortened atrial Effective Refractory Period (ERP) and Action Potential Duration (APD) [6], and late mechanical remodeling, such as cardiac hypertrophy and myocardial fibrosis [7]. (heraldopenaccess.us)
Risk of atrial fibrillation1
- The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis. (cdc.gov)
Development of atrial fibrillation2
- BACKGROUND: The development of atrial fibrillation (AF) is a complex multifactorial process. (maastrichtuniversity.nl)
- There are also certain physiological mechanisms explanations regarding the development of atrial fibrillation. (journalist-pro.com)
Ventricular Remodeling3
- This is a single center study conducted at a tertiary cardiology unit in Korea aimed at assessing ventricular remodeling post-ASD repair by utilizing cardiac magnetic resonance imaging (CMR). (thechipnetwork.org)
- Although rate control is important to stabilizing patients with AF, restoring sinus rhythm can slow or reverse the atrial and ventricular remodeling that leads to atrial dilation and left ventricular dysfunction. (medscape.com)
- In the past decade, a series of experimental studies using models with cell type-specific MRs uncovered the cellular and molecular mechanisms underlying its detrimental effect on left ventricular remodeling. (cardiovascularpharmacology.org)
Arrhythmia8
- After 33.11±21.45months, 170 patients recurred atrial arrhythmia, and reablation were applied in 117 patients. (medsci.org)
- Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia ( 1 ). (medsci.org)
- Despite that anti-arrhythmic drugs or cardioversion were used to control the recurred atrial arrhythmia, almost 10% patients had to accept reablation due to atrial arrhythmias that refractory to anti-arrhythmic drugs ( 6 ). (medsci.org)
- Although untreated atrial fibrillation doubles the risk of deaths related to heart disease, and is associated with a five fold increased risk for stroke, many patients still are unaware that this type of cardiac arrhythmia is a serious condition. (journalist-pro.com)
- Dr. Natale also is the Senior Medical Director at Pacific Atrial Fib and Arrhythmia Center in San Francisco. (jafib.com)
- After cardiac surgery, postoperative atrial fibrillation (POAF) is the most common type of arrhythmia with an incidence ranging from 33% to 49% 1 . (jafib.com)
- Atrial Fibrillation (AF) is the most common sustained arrhythmia which affects quality of life drastically [1]. (heraldopenaccess.us)
- Segment of an ECG showing atrial fibrillation, a rapid arrhythmia of the heart. (medscape.com)
Adverse atrial1
- We constructed pathway analysis of microRNAs' predicted gene targets to identify molecular processes involved in adverse atrial remodeling in AF. (uthscsa.edu)
Patients14
- Conclusions: Our data showed a great improvement in symptoms and positive cardiac remodeling after closure of ASD, more effective in elderly patients compared to younger patients. (unict.it)
- None of the patients had atrial fibrillation documented prior to surgery. (thechipnetwork.org)
- In the year 2000, for example, the UK spent around 665 million in hospitalizations, drugs, and home care of patients with atrial fibrillation [38]. (degruyter.com)
- The trial uses daily transtelephonic electrocardiographic monitoring for all patients and will be conducted within the German Atrial Fibrillation Competence NETwork (AFNET) to facilitate inclusion of patients from electrophysiologically oriented cardiology centers, ordinary hospitals, and office-based physicians. (nih.gov)
- However, risk factors to predict the reablation in patients with recurrence of atrial fibrillation are still uncertain. (medsci.org)
- However, the predictive value of atrial enlargement of reablation in patients with recurrence of AF is still unknown. (medsci.org)
- In this study, we assessed biatrial enlargement as a predictor for reablation in atrial fibrillation patients. (medsci.org)
- This clot risk is why patients with atrial fibrillation are given blood thinners medication. (journalist-pro.com)
- History and physical examination are important for diagnosing and risk stratifying patients with atrial fibrillation. (journalist-pro.com)
- Question: What should patients know about the 2014 AHA/ACC/HRS Atrial Fibrillation Guidelines? (stopafib.org)
- Antithrombotic therapy in patients with non-valvular atrial fibrillation in Southern Sweden: A population-based cohort study. (lu.se)
- Concomitant use of dronedarone with dabigatran in patients with atrial fibrillation in clinical practice. (lu.se)
- The data accumulated by our laboratory indicate that, in patients with paroxysmal / persistent AF without atrial magnification, CPVA alone is associated with excellent results, while in patients with long-lasting / persistent or permanent AF and with dilated atria, further linear lesions are necessary to achieve the non-inducibility of arrhythmias. (af-ablation.org)
- Optimal substitution by levothyroxine (LT4) restores biochemical euthyroidism.In postmenopausal women and elderly patients with hypothyroidism and associated vascularcomorbidity, excessive LT4 substitution could lead to atrial rhythm disorders and osteoporosis. (ac.rs)
Persistent2
- Persistent atrial fibrillation (AF) causes relevant mortality and cardiovascular and noncardiovascular morbidity. (nih.gov)
- Background-During persistent atrial fibrillation (AF), waves with a focal spread of activation are frequently observed. (maastrichtuniversity.nl)
Septal defect1
- Background: Atrial septal defect (ASD) represents a common congenital heart malformation, cause of right ventricle (RV) volume overload, pulmonary hypertension, atrial arrhythmias, and paradoxical emboli. (unict.it)
Tissue4
- In the following, assuming that the cardiac tissue other than the right atrium works properly, we investigate relations between degradation in right atrial tissue modeled by hybrid automata and the resultant rhythm of heartbeats. (frontiersin.org)
- This approach will provide detailed insights into the main pathological alterations associated with AF in atrial tissue and thereby contribute to the development of individualised, mechanistically informed patient-tailored treatment for AF. (maastrichtuniversity.nl)
- AF induction and electrophysiological studies, Ca2+ imaging with isolated atrial myocytes and HL-1 cells , and action potential duration (APD) measurements using atrial tissue and HL-1 cells were performed. (bvsalud.org)
- Wound healing is an extremely complex process consists of hemostasis, inflammation, cell proliferation and scar tissue remodeling phases. (fabad.org.tr)
Paroxysmal1
- On the other hand, atrial fibrillation might also come and go, which is what is called paroxysmal atrial fibrillation, however, sometimes it does not go away at all. (journalist-pro.com)
Pulmonary5
- However, infusion of CNP significantly attenuated the development of pulmonary hypertension and vascular remodeling. (atsjournals.org)
- Infiltration of inflammatory cells, which release many cytokines and growth factors, contributes to the development of pulmonary vascular remodeling ( 6 - 8 ). (atsjournals.org)
- The CPVA consists of large circumferential lines of injury performed point by point, so as to allow the disconnection of all pulmonary veins (PV), vagal denervation and the non-inducibility of both AF and atrial tachycardia (AT) at the end of the procedure. (af-ablation.org)
- Based on these findings, the potential of MR antagonists has been evaluated in other cardiovascular diseases, including coronary artery disease, arterial hypertension, heart failure with preserved ejection fraction, pulmonary hypertension, atrial fibrillation, and heart valve disease. (cardiovascularpharmacology.org)
- Video 10-3-1: Two-dimensional multiplanar TEE image at 75° in the mid-esophagus, showing the left atrium, left atrial appendage, left ventricle, and left upper pulmonary vein. (mhmedical.com)
Echocardiographic3
- Objective The purpose of this study was to identify candidate plasma microRNAs that are associated with echocardiographic phenotypes of atrial remodeling, and incident and prevalent AF in a community-based cohort. (uthscsa.edu)
- Echocardiographic parameters that reflect LA reservoir function are best associated with asymmetrical remodeling. (jafib.com)
- The recent publication on Carillon in the European Journal of Heart Failure - Treating symptoms and reversing remodelling: clinical and echocardiographic 1-year outcomes with percutaneous mitral annuloplasty for mild to moderate secondary mitral regurgitation - was particularly enlightening. (cardiacdimensions.com)
Hypertrophic cardiomyopathy1
- Genes associated with hypertrophic cardiomyopathy (HC) are not uniformly expressed in the atrial myocardium. (ajconline.org)
Myocardial infarction2
Myocardium1
- Comparison of the above variables between adult (3 mo) and senescent (24 mo) rats revealed significant phenotypic remodeling of B-AR mRNA distribution throughout the myocardium. (cdc.gov)
Flutter1
- For instance, supraventricular arrhythmias such as ectopic beats, atrial flutter, and fibrillation are the most frequent cardiac arrhythmias [8] and a major cause of stroke [12]. (degruyter.com)
Susceptibility1
- Whether this may impact susceptibility to atrial fibrillation (AF) is unresolved. (ajconline.org)
Atrium2
- Extracellular potentials recorded from isolated SAN/atrial preparations showed that, in the older rats, the leading pacemaker site was located more towards the inferior vena cava (l±0.3 mm from junction of superior vena cava with atrium in young and 2A±OA mm in old) and the spontaneous cycle length (CL) was greater by 24 % (i.e. intrinsic 'heart rate' was 20 % slower). (bl.uk)
- Video 10-2-1: Two-dimensional TEE image at 0° at the mid-esophageal level showing the left atrium and the left atrial appendage. (mhmedical.com)
Progression2
Cardioversion4
- This treatment concept that we call "targeted pharmacological reversal of electrical remodeling" would limit both cost and drug-induced side effects of antiarrhythmic drug therapy after cardioversion. (nih.gov)
- The Flec-SL trial, ISECTN62728743, therefore tests the main hypothesis that targeted pharmacological reversal of electrical remodeling by short-term antiarrhythmic drug therapy for 4 weeks after cardioversion is not inferior to standard long-term antiarrhythmic drug therapy for the prevention of recurrent AF after cardioversion in a parallel group, randomized, multicenter, open, blinded end point analysis design. (nih.gov)
- ECG-derived markers of atrial remodelling failed to predict treatment response in acute cardioversion of AF with vernakalant. (lu.se)
- Video 1-1-11: Transesophageal echocardiogram demonstrating a left atrial thrombus in a patient prior to planned cardioversion. (mhmedical.com)
Therapeutic2
- The findings of the present study suggest that isorhamnetin prevents AngII-induced AF vulnerability and arrhythmogenic atrial remodeling , highlighting its therapeutic potential as an anti-arrhythmogenic pharmaceutical or dietary supplement . (bvsalud.org)
- Understanding the relationship between miRNAs and atrial fibrillation is critical to identifying the diagnostic markers, prognosis and therapeutic targets. (heraldopenaccess.us)
Sinus rhythm4
- The early prognosis of cardiac afflictions such as atrial fibrillation and the response of a patient to a given treatment is believed to improve if the P wave is carefully analyzed during sinus rhythm. (degruyter.com)
- Considering atrial fibrillation, the analysis of the P wave during sinus rhythm is suggested as an approach for risk stratification [1]. (degruyter.com)
- Electrical remodeling, in contrast, is reversed by a few weeks of maintenance of sinus rhythm under experimental conditions. (nih.gov)
- If you have a patient with first episode of afib, and you choose to leave that patient in afib, five years later there will be enough remodeling where you'll never have the chance to get that patient back to sinus rhythm. (stopafib.org)
Stroke1
- Background - Left atrial (LA) compliance and contractility influence left ventricular stroke volume. (elsevier.com)
Echocardiography2
- Standard 2D, PW Doppler and 2D speckle tracking echocardiography were performed to assess left atrial (LA) and ventricular (LV) function and their role in predicting post-operative atrial fibrillation (POAF). (jafib.com)
- RV reverse remodeling was assessed by echocardiography at a median of 11.3 months (interquartile range [IQR] 5.9-13.5) post-dismissal. (elsevier.com)
Dilation1
- Objectives Left atrial (LA) dilation can evolve into asymmetrical remodeling. (jafib.com)
Hypertension3
- Atrial fibrillation (AF) has strong associations with other cardiovascular diseases, such as heart failure, coronary artery disease (CAD), valvular heart disease, diabetes mellitus, and hypertension. (medscape.com)
- Exposure to these factors leads to altered hemodynamics of the venous system, described as ambulatory venous hypertension, therefore promoting microcirculatory changes, inflammatory responses, hypoxia, venous wall remodeling, and epigenetic variations. (mdpi.com)
- The goal of this study was to employ high-resolution DT-MRI and the SHR animal model to assess the transmural layer-specific remodeling of myocardial microstructure associated with hypertension. (osti.gov)
Vascular3
- C-type natriuretic peptide (CNP) has been shown to act as a local regulator of vascular tone and remodeling. (atsjournals.org)
- CNP binds to natriuretic peptide receptor B, which bears a guanylate cyclase, induces generation of cGMP ( 11 ), and acts as a local regulator of vascular tone and remodeling ( 12 ). (atsjournals.org)
- Obstructive sleep apnea (OSA) is characterized by intermittent airway obstruction and systemic hypoxia during sleep, which can contribute to an increase in reactive oxygen species, vascular remodeling, vasoconstriction and ultimately cardiovascular disease. (cdc.gov)
MicroRNA2
- AF-related atrial fibrotic remodeling results from a program of microRNA changes acting on cardiac fibroblasts. (icm-mhi.org)
- 3. Transient Receptor Potential 3 (TRPC3) channels regulate atrial fibroblast Ca2+-entry and contribute to the fibrotic AF substrate under the control of microRNA-26. (icm-mhi.org)
Mitral2
- Michael Haude, MD, PhD. Percutaneous Coronary Sinus-Based Mitral Valve Annuloplasty in Atrial Functional Mitral Regurgitation. (cardiacdimensions.com)
- Video 10-3-3: Three-dimensional live zoom image from the atrial perspective, showing the mitral valve (MV) and left atrial appendage (LAA) occluder device. (mhmedical.com)
Thrombus1
- This image shows thrombus attached near the apex of the left atrial appendage (LAA). (mhmedical.com)
Chambers of the heart1
- Generally, in atrial fibrillation, the electrical impulses in the top two chambers of the heart, called atria, fire chaotically when they should be regular and steady that cause them to twitch or quiver (fibrillation). (journalist-pro.com)
Enlargement1
- He was found to have constrictive physiology during cardiac catheterization, with cardiac MRI demonstrating hepatic vein dilatation, atrial enlargement and ventricular narrowing. (biomedcentral.com)
Refractory2
- Isorhamnetin decreased AF inducibility compared with the AngII group and restored AngII-induced atrial effective refractory period prolongation. (bvsalud.org)
- On top of that, tachycardia (rapid heartbeat) and shortening of the refractory period lead to electrical remodeling in the heart. (journalist-pro.com)
Antiarrhythmic2
- Antiarrhythmic drugs that prolong the atrial action potential can assist in the prevention of recurrent AF by promoting the reversal of electrical remodeling. (nih.gov)
- Some important contributions of Dr. Nattel's group have included the discovery of a novel atrial-specific K+ channel in the human heart, the cloning, characterization and functional analysis of novel K+-channel subunits, the delineation of the molecular and functional basis of atrial fibrillation and the identification of a variety of novel targets for antiarrhythmic drug therapy. (icm-mhi.org)
Symptoms1
- Concurrently, sometimes people do not experience any symptoms and atrial fibrillation gets detected when having an examination or check up. (journalist-pro.com)
Occurrence1
- Small-conductance Ca2+-dependent K+-channels participate in AF occurrence via regionally determined and remodeling-induced differences in atrial repolarization. (icm-mhi.org)
Methods1
- Methods We analyzed left atrial function index (LAFI) of 1788 Framingham Offspring 8 participants. (uthscsa.edu)
Coronary1
- Leon introduced a simple technique of aortic root remodeling without the handling of coronary ostia that involved the excision of most of the aortic root wall except around the coronary ostia (13). (ctsnet.org)
Predictive1
- P =.004) was predictive of early RV reverse remodeling. (elsevier.com)
Right ventricle1
- In the diagnosis for TR, an accurate evaluation of the complex tricuspid anatomy and remodelling of the right ventricle is pivotal. (escardio.org)
