Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.Benzimidazoles: Compounds with a BENZENE fused to IMIDAZOLES.TetrazolesCaptopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Angiotensin II Type 1 Receptor Blockers: Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.1-Sarcosine-8-Isoleucine Angiotensin II: An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR.Tachycardia, Ectopic Atrial: Abnormally rapid heartbeats originating from one or more automatic foci (nonsinus pacemakers) in the HEART ATRIUM but away from the SINOATRIAL NODE. Unlike the reentry mechanism, automatic tachycardia speeds up and slows down gradually. The episode is characterized by a HEART RATE between 135 to less than 200 beats per minute and lasting 30 seconds or longer.Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.Tachycardia, Supraventricular: A generic expression for any tachycardia that originates above the BUNDLE OF HIS.Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Catheter Ablation: Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.Aortic Valve Stenosis: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.Heart Valve Prosthesis Implantation: Surgical insertion of synthetic material to repair injured or diseased heart valves.Ventricular Remodeling: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.Aortic Valve: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.Heart Atria: The chambers of the heart, to which the BLOOD returns from the circulation.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.Sick Sinus Syndrome: A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Pacemaker, Artificial: A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).Arrhythmia, Sinus: Irregular HEART RATE caused by abnormal function of the SINOATRIAL NODE. It is characterized by a greater than 10% change between the maximum and the minimum sinus cycle length or 120 milliseconds.Sinoatrial Node: The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).Asymptomatic Diseases: Diseases that do not exhibit symptoms.Pulmonary Veins: The veins that return the oxygenated blood from the lungs to the left atrium of the heart.Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.National Institute of General Medical Sciences (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic biomedical research that is not targeted to specific diseases and funds studies on genes, proteins, and cells, as well as on fundamental processes like communication within and between cells and metabolism. It was established in 1962.Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Atmosphere: The gaseous envelope surrounding a planet or similar body. (From Random House Unabridged Dictionary, 2d ed)Endoplasmic Reticulum: A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Membrane Potential, Mitochondrial: The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.Endoplasmic Reticulum Stress: Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.Venturicidins: Toxic substances isolated from various strains of Streptomyces. They are 20-membered macrolides that inhibit oxidative phosphorylation and mitochondrial ATPases. Venturicidins A and B are glycosides. Used mainly as tools in the study of mitochondrial function.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Rhodospirillaceae: A family of phototrophic bacteria, in the order Rhodospirillales, isolated from stagnant water and mud.Hydroponics: A technique for growing plants in culture solutions rather than in soil. The roots are immersed in an aerated solution containing the correct proportions of essential mineral salts. (From Concise Dictionary of Biology, 1990)Musa: A plant genus of the family Musaceae, order Zingiberales, subclass Zingiberidae, class Liliopsida.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Connexin 43: A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.Connexins: A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.JNK Mitogen-Activated Protein Kinases: A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.Gap Junctions: Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.Mitogen-Activated Protein Kinases: A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Atrial Appendage: Ear-shaped appendage of either atrium of the heart. (Dorland, 28th ed)Echocardiography, Transesophageal: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.Atrial Function, Left: The hemodynamic and electrophysiological action of the LEFT ATRIUM.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Thromboembolism: Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.
Pre-procedural prediction of termination of persistent atrial fibrillation by catheter ablation as an indicator of reverse remodeling of the left atrium. (1/11)BACKGROUND: The pre-procedural prediction of atrial fibrillation (AF) termination by catheter ablation in patients with persistent AF has not been evaluated fully. The aim of this study was to evaluate the pre-procedural predictors of persistent AF termination by ablation associated with the possibility of reverse remodeling of the left atrium (LA). METHODS AND RESULTS: Seventy consecutive patients (mean age, 62+/-8 years) with persistent or long-standing persistent AF underwent ablation. They were divided into 2 groups: those with AF terminated by ablation (n=14; group 1) and those with AF terminated by cardioversion after ablation (n=56; group 2). The left atrial appendage (LAA) contraction velocity determined on transesophageal echocardiography was significantly decreased in group 2 as compared to group 1 (P<0.001). Kaplan-Meier analysis showed that the group 1 patients had a higher AF-free survival rate than those in group 2 during 12+/-4.1 months of follow-up (P=0.048). The LA reverse remodeling ratio, given as the volume difference between before and 3 months after ablation in group 1, was significantly greater after ablation than that in group 2 (25.8+/-13% vs. 15.0+/-15%, P=0.015). Multivariate logistic regression analysis indicated that the LAA contraction velocity was an independent predictor of persistent AF termination by ablation (P=0.018). CONCLUSIONS: The LAA contraction velocity was the only non-invasive pre-procedural predictor of persistent AF termination by ablation, indicating the possibility of reverse remodeling of the LA. (+info)
Changes in microRNAs expression are involved in age-related atrial structural remodeling and atrial fibrillation. (2/11)BACKGROUND: Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been implicated in the aging process and in the regulation of extracellular matrix proteins. However, their role in age-related cardiac remodeling and atrial fibrillation (AF) was not well understood. The present study was designed to decipher molecular mechanisms underlying age-related atrial structural remodeling and AF. METHODS: Three groups of dogs were studied: adult and aged dogs in sinus rhythm and with persistent AF induced by rapid atrial pacing. The expressions of microRNAs were measured by quantitative real-time polymerase chain reaction. Pathohistological and ultrastructural changes were tested by light and electron microscopy. Apoptosis index of myocytes was detected by TUNEL. RESULTS: Samples of atrial tissue showed the abnormal pathohistological and ultrastructural changes, the accelerated fibrosis, and apoptosis with aging and/or in AF dogs. Compared to the adult group, the expressions of microRNAs-21 and -29 were significantly increased, whereas the expressions of microRNAs-1 and -133 showed obvious downregulation tendency in the aged group. Compared to the aged group, the expressions of microRNAs-1, -21, and -29 was significantly increased in the old group in AF; contrastingly, the expressions of microRNA-133 showed obvious downregulation tendency. CONCLUSION: These multiple aberrantly expressed microRNAs may be responsible for modulating the transition from adaptation to pathological atrial remodeling with aging and/or in AF. (+info)
An Angiotensin receptor blocker prevents arrhythmogenic left atrial remodeling in a rat post myocardial infarction induced heart failure model. (3/11)(+info)
Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing. (4/11)(+info)
MicroRNAs in pulmonary arterial remodeling. (5/11)(+info)
Left atrial endocardial fibrosis and intra-atrial thrombosis - landmarks of left atrial remodeling in rats with spontaneous atrial tachyarrhythmias. (6/11)INTRODUCTION: Histological abnormalities are common findings in the left atria (LA) of atrial fibrillation (AF) patients. We aimed to assess LA histological abnormalities in our model of spontaneous atrial tachyarrhythmias in rats. MATERIALS AND METHODS: LA sampling was performed in 12 spontaneously hypertensive rats (SHRs) and eight age-matched Wistar-Kyoto (WKY) rats. Tissue sections were stained with Masson's trichrome and Hematoxylin-Eosin-Safran and examined with a light microscope. A 0 to 3 scoring system was used to quantify the severity of LA structural abnormalities. LA von Willebrand factor (vWF) content was also assessed using immunohistochemical staining. RESULTS: In six of the eight SHRs, LA fibrosis, inflammatory infiltrates, and myocyte necrosis of varying grades of severity were observed. The most frequent feature was endocardial fibrosis, which was observed in six SHRs and in none of the WKY rats. Intra-atrial thrombosis was found in three SHRs and in none of the WKY rats. The intensity of vWF-related fluorescence was higher in the atrial endocardium of SHRs compared to age-matched WKY rats. CONCLUSIONS: Our findings reinforce the role of LA structural abnormalities in atrial arrhythmogenicity. However, two SHRs did not present LA histological abnormalities despite the presence of arrhythmias. This finding suggests that the LA remodeling-atrial tachyarrhythmia relationship could be highly nonlinear and that atrial fibrosis is more likely to be a facilitator of atrial arrhythmogenicity, rather than a prerequisite. We also provide evidence that intra-atrial thrombosis accompanies LA structural remodeling in arrhythmic rats. Increased endocardial platelet adhesion molecule vWF could contribute to this increased thrombogenicity. (+info)
Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation. (7/11)(+info)
Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing. (8/11)(+info)
AF is very rare in children so it would be no surprise if theres not much out there. If you want this question to remain open, you should edit it and add some of the information youve found so far because MedSci requires questions to demonstrate at least some level of prior research. - Carey Gregory♦ Nov 9 18 at 19:49 ...
Tokyo ― Terumo Corporation (TSE: 4543 Section 1) announced CE marking for the commercial sale of the Iberis™ Renal Sympathetic Denervation System, which the company has consigned product development to Shanghai AngioCare Medical Technology Co., Ltd. (hereinafter AngioCare) (Representative: Philip Wang), a Chinese company in renal sympathetic denervation technology for resistant hypertension treatment.. In December, 2012, Terumo formed a strategic alliance with AngioCare. Furthermore, the company has consigned product development to AngioCare and acquired the exclusive distribution rights for its renal sympathetic denervation technology on the global market.. Sales of Iberis in Europe will be commenced with its launch at the worlds leading cardiovascular intervention course, EuroPCR to be held in France in May, 2013.. Terumo aims to expand its renal sympathetic denervation business by launching Iberis in Asian and Latin American countries where the CE marked product is allowed for ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
REnal SympathetiC Denervation to sUpprEss Tachyarrhythmias in ICD Recipients - Full Text View - ClinicalTrials.gov
The objective of this trial is to determine the efficacy and safety of adjunctive catheter-based renal sympathetic denervation (RSDN) in the primary prevention of ICD therapy in patients with ischemic or non-ischemic ventricular dysfunction, who are to receive an ICD for either i) secondary prevention, or ii) primary prevention + inducible VT by programmed ventricular stimulation at the time of ICD implantation. These patients will be randomized to ICD alone or ICD + RSDN ...
REnal SympathetiC Denervation to sUpprEss Tachyarrhythmias in ICD Recipients - Full Text View - ClinicalTrials.gov
The objective of this trial is to determine the efficacy and safety of adjunctive catheter-based renal sympathetic denervation (RSDN) in the primary prevention of ICD therapy in patients with ischemic or non-ischemic ventricular dysfunction, who are to receive an ICD for either i) secondary prevention, or ii) primary prevention + inducible VT by programmed ventricular stimulation at the time of ICD implantation. These patients will be randomized to ICD alone or ICD + RSDN ...
Acupuncture Points location, description, functions, picture, acupuncture point chart. Look for specific acupuncture points and their uses. See pictures, charts and learn common uses and location.
Measurement of funny current (I(f)) channel mRNA in human atrial tissue: Correlation with left atrial filling pressure and...
TY - JOUR. T1 - Measurement of funny current (I(f)) channel mRNA in human atrial tissue. T2 - Correlation with left atrial filling pressure and atrial fibrillation. AU - Lai, Ling Ping. AU - Su, Ming Jai. AU - Lin, Jiunn Lee. AU - Tsai, Chang Her. AU - Lin, Fang Yue. AU - Chen, Yih Sharng. AU - Hwang, Juey Jen. AU - Stephen Huang, Shoei K.. AU - Tseng, Yung Zu. AU - Lien, Wen Pin. PY - 1999/1/1. Y1 - 1999/1/1. N2 - Introduction: The funny current (I(f)) contributes to phase IV spontaneous depolarization in cardiac pacemaker tissue. Enhanced I(f) activity in myocardial tissue may lead to increased automaticity and therefore tachyarrhythmia. We measured the amount of I(f) activity in the messenger ribonucleic acid (mRNA) in human atrial tissue and correlated the mRNA amount to left atrial filling pressure and atrial fibrillation (AF). Methods and Results: A total of 34 patients undergoing open heart surgery were included (15 men and 19 women, aged 55 ± 10 years). Atrial tissue was obtained from ...
This MATLAB function displays the vectors specified by U and V, where U contains the x components as relative coordinates, and V contains the y components as relative coordinates.
Full nutritional breakdown of the calories in Microwave Peanut Brittle based on the calories and nutrition in each ingredient, including Peanuts, dry-roasted, Granulated Sugar, Light Corn Syrup, Butter, salted, Vanilla Extract and the other ingredients in this recipe.
Endokardfibrosen: Klinik, Therapie, Pathologie. | Annals of Internal Medicine | American College of Physicians
In this monograph Dr. Wenger has reviewed some 800 cases of endocardial fibro-elastosis from the literature and has reported 40 cases of his own. The result of his labors is a useful collection of data and references dealing with this poorly understood disorder. The author distinguishes five "types" of endocardial fibrotic change and divides his material therefore into these five major categories: (1) Endocardial fibro-elastosis, (2) Endomyocardial fibrosis, (3) Endocarditis parietalis fibroplastica, (4) Endocardial changes in the carcinoid syndrome, and (5) Secondary patchy endocardial fibrosis of the adult.. Irrespective of the validity of this division, these headings allow the author ...
Doppler flow measurement using surface integration of velocity vectors (SIVV) : in vitro validation.
Blood flow measurement using an improved surface integration of velocity vectors (SIVV) technique was tested in in vitro phantoms. SIVV was compared with true flow (12-116 mL/s) in a steady-state model using two angles of insonation (45 degrees and 60 degrees ) and two vessel sizes (internal diameter = 11 and 19 mm). Repeatability of the method was tested at various flow rates for each angle of insonation and vessel. In a univentricular pulsatile model, SIVV flow measured at the mitral inlet was compared to true flow (29-61 mL/s). Correlation was excellent for the 19-mm vessel (r(2)= 0.99). There was a systematic bias but close limits of agreement (mean +/- 2 SD = -24.1% +/- 7.6% at 45 degrees; +16.4% +/- 11.0% at 60 degrees ). Using the 11-mm vessel, a quadratic relationship was demonstrated between between SIVV and true flow (r(2) = 0.98-0.99), regardless of the angle of insonation. In the pulsatile system, good agreement and correlation were shown (r(2) = 0.94, mean +/- 2 SD = -4.7 +/- ...
US5310562A - Composition and method for reparation and prevention of fibrotic lesions - Google Patents
In a preferred embodiment, drugs having heretofore unknown pharmacological properties which are useful in the medicinal therapy of fibrotic disease for the reparation and prevention of fibrotic lesional tissues, such drugs including as the active ingredient 5-methyl-1-phenyl-2-(1H)-pyridone. The pharmaceutical composition of this invention is novel as an anti-fibrotic drug, namely, as an agent for treating fibrosis. Any existing compounds have not been shown to be effective for the reparation and prevention of fibrotic lesions.
You are definitely on the right track. You can continue by first combining terms on the velocity so that you have the results in the form ai+bj+ck. The rate at which work is being done at any time is equal to the force F dotted with the velocity vector. Evaluate this dot product, and then integrate with respect to t. What is the formula for the change in KE in terms of the initial and the final velocity ...
Renal Sympathetic Denervation | Medical Microwave Ablation Technology and Devices | Symple Surgical Inc., (SSI) | Northern...
Symple Surgical Inc., (SSI) is a developer of novel ablation technologies using controlled Microwave Energy. Symple Surgical innovation is for the treatment of resistant hypertension via renal sympathetic denervation. The DirectAblate Catheter delivers microwave energy to the depth-specific location of the sympathetic nerves while minimizing thermal exposure to non-targeted areas. Offices located in Northern California and Flagstaff, AZ.
Velocity and Acceleration of a particle around a circle | Physics Forums - The Fusion of Science and Community
well, I found an equation of a= (v^2)/2 i, which gave an acceleration of a = 8 m/s i. I dont understand how this equation was derived. Although, now that I have actually thought about this, the acceleration vector around a curve or a circle always points toward the center of the circle and the velocity vector is always tangent to the point on the curve, so I understand how the acceleration vector is i and the velocity vector is j for x=-2,y=0. The only problem I have is the equation I came across ...
A method of controlling scar formation in humans by applying a force to tissue in an amount to create a wound; applying a lathyrogenic agent to the wound; forming the wound into a predetermined stationary or moveable beneficial configuration; and maintaining the wound in the predetermined configuration and in contact with lathyrogenic agent during healing.
Session VI - Recognizing Grey - controversial and ambiguous issues in cardiology. Chairpersons: J. J. Bax (Leiden, NL). B. Khandheria (Milwaukee, WI USA). 11:00 a.m. K. Narkiewicz (Gdańsk, PL). Hidden mechanisms of arterial hypertension. 11:30 a.m. J. J. Bax (Leiden, NL). Imaging to select patients for TAVI. 12:00 p.m. S. Q. Allaqaband (Milwaukee, WI USA). Interventions in structural heart disease. 12:30 p.m. F. Mahfoud (Homburg, D). Renal sympathetic denervation: should we go beyond resistant hypertension?. 01:00 p.m. M. Miglinas (Vilnius, LT). Blood pressure lowering and target organ protection: coherent or diverging effects?. 01:30 p.m. Concluding Remarks. Remigijus Zaliunas (Kaunas, LT). Rimvydas Slapikas (Kaunas, LT). Germanas Marinskis (Vilnius, LT). Zaneta Petrulioniene (Vilnius, LT ...
carbon dioxide angiography, chronic kidney disease (CKD), contrast nephropathy, renal sympathetic denervation, uncontrolled hypertension Background
Definition and Overview A keloid is a skin disorder subsequent from an abnormal or unnecessary development of scar tissue after a deep injury or wound has healed. It is a dermal fibrotic lesion ...
Study Flashcards On 6-04 msk/derm/vasc at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Identification of discrete surfaces. A: whole cardiac mesh [including atrial tissue] produced from Tetgen showing the tagged tetrahedral elements: myocardium (g
Severe Renal Artery Stenosis After Renal Sympathetic Denervation | JACC: Cardiovascular Interventions
Since 2012, several cases of renal stenosis after renal denervation have been reported, demonstrating a wide spectrum of clinical presentation, but presenting recurrent hypertension as most relevant finding (1).. In the previous trials HTN-1 (Symplicity Renal Denervation in Patient With Refractory Hypertension) (2) and EnligHTN-I (Safety and Efficacy of Study of Renal Artery Ablation in Resistant Hypertension Patients) (3), renal artery stenosis had been attributed mainly to pre-existing artery stenosis worsening and not to a de novo procedure-related adverse event. The increasing reports of the last call into question the safety of this procedure and point to this complication as a possible cause of therapy ineffectiveness. ...
The Role of Fibroblasts in Complex Fractionated Electrograms During Persistent/Permanent Atrial Fibrillation | Circulation...
Methods and Results: We used a human atrial tissue model in heart failure and simulated propagation and spiral wave reentry with and without regionally proliferated fibroblasts. Coupling of fibroblasts to atrial myocytes resulted in shorter action potential duration, slower conduction velocity, and lower excitability. Consequently, heterogeneous fibroblast proliferation in the myocardial sheet resulted in frequent spiral wave breakups, and the bipolar electrograms recorded at the fibroblast proliferation area exhibited CFAEs. The simulations demonstrated that ablation targeting such fibroblast-derived CFAEs terminated AF, resulting from the ablation site transiently pinning the spiral wave and then pushing it out of the fibroblast proliferation area. CFAEs could not be attributed to collagen accumulation alone.. ...
Coarctation of the aorta is a narrowing of the descending aorta, which is typically located at the insertion of the ductus arteriosus just distal to the left subclavian artery (). This defect generally results in left ventricular pressure overload.Th
23] Mandache E, Gherghiceanu M, Macarie C, et al., Telocytes in human isolated atrial amyloidosis: ultrastructural remodelling ... tissue homoeostasis and remodelling/renewal . Figure 9. Human mammary gland stroma: TEM; original magnification 9,100x. A: ...
"Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling". The Journal of ... Ablation of sarcolipin increases atrial Ca2+ transient amplitudes and enhanced atrial contractility. Furthermore, atria from ... "Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility". Proceedings of the National ...
"Increased Ca buffering underpins remodelling of Ca(2+) handling in old sheep atrial myocytes". The Journal of Physiology. 595 ( ... Calcium buffering within atrial myocytes is affected by ageing in large animal models, elevating sarcoplasmic reticulum calcium ... content, which could potentially contribute towards a tendency to atrial fibrillation. Neuroscience portal Calcium channel ...
"Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure". ... "Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice". The Journal of Clinical Investigation. 120 ( ...
"Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovasc. Res. 83 (3): ...
This suggests that budiodarone may promote atrial re-modelling to improve malfunctioning ion channels that once potentiated ... in patients with paroxysmal atrial fibrillation and pacemakers with atrial fibrillation data logging capabilities [abstract]. ... Amiodarone to prevent recurrence of atrial fibrillation. N Engl J Med. 2000;342:913-920 Singh, B.N., et al. Amiodarone versus ... A decrease in heart rate reduces the risk of atrial fibrillation. Preliminary trials of budiodarone have administered the drug ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4: 129-37. doi:10.1159/000381543. PMC ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4: 129-37. doi:10.1159/000381543. PMC ...
2009). "Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovasc Res. ... of miR-590 by nicotine has been found to play a key part in the generation of atrial fibrosis by atrial structural remodelling ...
"Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs". ... In a porcine model of left atrial remodeling following mitral regurgitation, VLC-2 was shown to be upregulated. Human ALC-2 is ... Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans ... In a canine model of atrial fibrillation, decreased atrial contractility was associated with decreased ALC-2 and myosin binding ...
pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ... Throughout life, the cardiac collagen skeleton is remodeled. Where collagen is diminished by age, calcium is often deposited, ... venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... The AV node is the only electrical conduit from the atria to the ventricles through the cardiac skeleton, which is why atrial ...
The recently remodeled atrium looks better than ever with its new and spacious gardens that are home to different types of ... Its pink stone facade has a tower composed of three bodies; there are cross atrial figures of the Passion of the Christ and of ...
... selectively increases atrial refractory period by 22% in dogs with atrial tachycardia induced electrical remodeling. ... During atrial fibrillation this process becomes chaotic and the atrial depolarization occurs faster than it should causing the ... A recognized atrial selective drug target is Kv1.5, which is found in atria but not in ventricles. Kv1.5 carries the ultra ... Atrial Fibrillation (AF) is an arrhythmia that occurs in 1-2% of the general population. AF is linked to several cardiac causes ...
It is also believed that angiotensin directly affects cardiac remodeling, and blocking its activity can thereby slow the ... Glucocorticoids induce a potent diuresis in heart failure because they could improve renal responsiveness to atrial natriuretic ... It is also thought that catecholamines and other sympathomimetics have an effect on cardiac remodeling, and blocking their ... These commonly involve surgical left ventricular remodeling. The aim of the procedures is to reduce the ventricle diameter ( ...
One reason for this may be that once the heart has undergone atrial remodeling as in the case of chronic atrial fibrillation ... AF therefore have an increased chance of success with an ablation since their heart has not undergone atrial remodeling yet. ... Risks of catheter ablation for atrial fibrillation include, but are not limited to: stroke, esophageal injury and death. ... Long-term single procedure efficacy of catheter ablation of atrial fibrillation. J Interv Card Electrophysiol (2006) 15:145-155 ...
For example, MMP9 appears to be involved in the remodeling associated with malignant glioma neovascularization. It is also a ... MMP9 levels increase with the progression of idiopathic atrial fibrillation. MMP9 has been found to be associated with the ... Gelatinase B plays a central role in tumor progression, from angiogenesis, to stromal remodeling, and ultimately metastasis. ... which are key effectors of ECM remodeling. MMP9, along with elastase, appears to be a regulatory factor in neutrophil migration ...
"2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial ... Left ventricular hypertrophy and left ventricular remodeling Diminished coronary flow reserve and silent myocardial ischemia ... often termed diastolic heart failure Atrial fibrillation, other cardiac arrhythmias, or sudden cardiac death Heart failure can ... hypertrophy in athletes Congestive heart failure or heart failure with normal ejection fraction due to other causes Atrial ...
These thickenings will go on to fuse and remodel to eventually form the valves and septa of the mature adult heart. Endocardial ... Upon sectioning of the heart the atrioventricular endocardial cushions can be observed in the lumen of the atrial canal as two ... A problem in endocardial cushion development or remodeling is thought to be associated with atrioventricular septal defect. The ... As heart development continues this tube undergoes conformational changes and remodeling to eventually form the four-chambered ...
... , also called atrial natriuretic peptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene. ... Corin-mediated ANP production in the pregnant uterus promotes spiral artery remodeling and trophoblast invasion. CORIN ... Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt- ... Wu F, Yan W, Pan J, Morser J, Wu Q (May 2002). "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes". The ...
Working on sino atrial node cells by inhibiting T-type calcium channel activation, Efonidipine prolongs the late phase-4 ... By reducing synthesis and secretion of aldosterone, Efonidipine prevents hypertrophy and remodeling of cardiac myocytes. ... depolarization of the sino atrial node action potential and suppresses an elevated HR. The negative chronotropic effect of ...
Veno-occlusive remodelling. This theory proposes how high pulmonary venous pressures may lead to the capillary rupture ... pulmonary infection or atrial fibrillation, inflammation, longer distances, longer duration of exercise, hard surfaces, ... Other histopathologic findings include fibrosis, bronchial artery neovascularization, venous remodeling, bronchiolitis, ... with the venous remodeling leading to regional vascular congestion and hemorrhage, hemosiderin accumulation, fibrosis, and ...
One reason for this may be that once the heart has undergone atrial remodeling as in the case of chronic atrial fibrillation ... AF therefore have an increased chance of success with an ablation since their heart has not undergone atrial remodeling yet. ... For atrial fibrillation, several experienced teams of electrophysiologists in US heart centers claim they can achieve up to a ... Risks of catheter ablation for atrial fibrillation include, but are not limited to: stroke, esophageal injury, pulmonary vein ...
However, atrial natriuretic peptide is thought to be cardio-protective. Remodeling of the heart is evaluated by performing an ... Physiological remodeling is reversible while pathological remodeling is mostly irreversible. Remodeling of the ventricles under ... In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of ... This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling ...
"Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy". Nature. 484 (7393): 246-50. Bibcode: ... These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood ... ANP is secreted in response to: Stretching of the atrial wall, via Atrial volume receptors Increased Sympathetic stimulation of ... ANP is also called atrial natriuretic factor (ANF), atrial natriuretic hormone (ANH), cardionatrine, cardiodilatin (CDD), and ...
... reducing atrial contractility and potentially contributing to atrial fibrillation. Structural changes in T-tubules can lead ... as some suggest that T-tubule remodelling might be reversed through the use of interval training. ... T-tubules are found in both atrial and ventricular cardiac muscle cells (cardiomyocytes), in which they develop in the first ... in 2009 an extensive T-tubule network in atrial cardiac muscle cells was observed. Ongoing research focusses on the ...
The difference between aortic and right atrial pressure accounts for blood flow in the circulation. When the left ventricle ... and then undergo a significant remodelling to form the final asymmetrical structure of the great arteries, with the 3rd ...
For atrial fibrillation, 120 to 200 joules for biphasic devices and 200 joules for monophasic devices For atrial flutter, 50 to ... They also decrease cardiac oxygen demand and can prevent cardiac remodeling. Not all beta blockers are the same; some are ... including atrial fibrillation and atrial flutter. It is also used in the emergent treatment of wide complex tachycardias, ... It has been shown to be effective in acute cardioversion of recent-onset atrial fibrillation and atrial flutter. Class IV drugs ...
Atrial stretch induced by increased atrial pressure may precipitate atrial fibrillation through some effect on atrial ... Thus, it is possible that the elevation of atrial pressure might cause electrical remodeling by the upregulation of atrial AT1 ... However, long-term rapid atrial pacing might be necessary to examine the time course of atrial electrical remodeling and the ... Therefore, we continued rapid atrial pacing for 3 hours, which was enough to evaluate acute atrial electrical remodeling. In ...
... and such a remodeling has also been called atrial tachycardia remodeling.1,2,42,43 Atrial tachycardia remodeling is suggested ... Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to ... Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial- tachycardia remodeling in dogs. ... Background-A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated ...
Left atrial (LA) enlargement is a common finding in hypertensive patients (pts), however little information is available on LA ... OBJECTIVES: Left atrial (LA) enlargement is a common finding in hypertensive patients (pts), however little information is ... hypertension showed a more marked increased of LA volumes compared to gestational hypertension due to a remodeling of atrial ...
... causes tachycardia-induced atrial electrical remodeling, contributing to the progressive nature of the arrhythmia. Ventricular ... dysfunction due to a rapid response to AF can cause structural remodeling, but whether ... OBJECTIVE: Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling, contributing to the progressive ... Atrial tissue from 1-week atrial-tachypaced dogs with ventricular rate control similarly showed upregulation of alpha SMA ...
... levels predict left atrial reverse remodeling after catheter ablation in patients with atrial fibrillation (AF) ... HealthDay News - Preprocedural serum atrial natriuretic peptide (ANP) levels predict left atrial reverse remodeling after ... "In this study, 47% of the patients exhibited left atrial reverse remodeling after RFCA for AF, with a concomitant improvement ... before RFCA and maintenance of sinus rhythm during follow-up were independent predictors of left atrial reverse remodeling ( ...
... cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial ... either of atrial or of ventricular origin, remains a major challenge. Sudden ... Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias. ... The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden ...
Measurement of left atrial (LA) volume by the biplane area-length method where A2Ch and A4Ch refer to the LA area in the two- ... Background Left atrial (LA) size is an adverse prognostic marker. Aortic stenosis results in increased filling pressures with ... progressive left atrial enlargement and dysfunction. Intervention for aortic stenosis results in LV reverse remodelling, ...
Atrial Fibrillation. Atrial Remodeling. Vascular Diseases. Cardiovascular Diseases. Arrhythmias, Cardiac. Heart Diseases. ... Structural Remodeling (left atrial volume, left. *ventricular mass, left ventricular diastolic function. Evaluated at ... Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and ... Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension, Permanent ...
Atrial natriuretic peptide (ANP) reduces pulmonary vascular resistance and attenuates hypoxia-induced pulmonary hypertension in ... Measurement: pulmonary hypertension, right ventricular hypertrophy, and pulmonary arterial and alveolar remodeling were ... to test the hypothesis that ANP modulates the pulmonary vascular and alveolar remodeling response to normobaric hypoxic stress ... resulting in pulmonary vascular remodeling characterized by hyperplasia of pulmonary arterial smooth muscle cells (PASMCs) and ...
Defining biological markers of atrial remodelling would help identify patients at high risk who would benefit most from ... Biomarkers of atrial fibrillation progression would be helpful for following patients that present with asymptomatic atrial ... Notably, the roles of such markers in the pathophysiology of atrial fibrillation must be determined. Some markers may indicate ... Although a number of markers have been reported as potential predictors of paroxysmal atrial fibrillation progression towards ...
Atrial fibrillation begets atrial fibrillation: autonomic mechanism for atrial electrical remodeling induced by short-term ... seem to play a more relevant role for atrial electrical remodeling during AF. Atrial electrical remodeling results mainly from ... Renal Sympathetic Denervation Provides Ventricular Rate Control But Does Not Prevent Atrial Electrical Remodeling During Atrial ... Renal Sympathetic Denervation Provides Ventricular Rate Control But Does Not Prevent Atrial Electrical Remodeling During Atrial ...
1999) Promotion of atrial fibrillation by heart failure in dogs Atrial remodeling of a different sort. Circulation, 100, 87-95 ... 1999) Promotion of atrial fibrillation by heart failure in dogs: Atrial remodeling of a different sort. Circulation, 100, 87-95 ... symptomatic atrial fibrillation and heart failure. Randomized studies and observational data suggest that atrial fibrillation ... TITLE: Atrial fibrillation ablation in patients with heart failure review. AUTHORS: Mohammad I. Amin, Laurence D. Sterns, ...
Whether increased MMP activity directly contributes to atrial remodeling and AF in the setting of HF remains unclear. The ... play a role in extracellular remodeling, and recent studies have demonstrated increased atrial MMP activity in HF. ... The SAVP-MMPi dogs had significantly smaller increases in atrial myocyte cross sectional area, collagen area fraction, and MMP- ... current study examined the effects of MMP inhibition on atrial structural remodeling and AF vulnerability during HF progression ...
Background The contribution of progressive left atrial (LA) enlargement to elevated pulmonary capillary wedge pressure (PCWP) ... Association of echocardiographic atrial size and atrial fibrosis in a sequential model of congestive heart failure and atrial ... Effects of quinapril on left atrial structural remodeling and arterial stiffness. Am J Cardiol. 2006;97(6):916-20.CrossRef ... Contribution of the left atrial remodeling to the elevated pulmonary capillary wedge pressure in patients with WHO Group II ...
Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation. 1999;100:87-95. ... Electrical remodeling of the human atrium: similar effects in patients with chronic atrial fibrillation and atrial flutter. J ... Reverse atrial electrical remodelling following atrial defibrillation as determined by signal-averaged ECG. Can J Cardiol. 2004 ... Relevance of Electrical Remodeling in Human Atrial FibrillationClinical Perspective. Results of the Asymptomatic Atrial ...
... worlds leading medical scientists to share in a highly interactive environment the most recent advances in the field of atrial ... ionic remodeling and atrial fibrosis. Atrial fibrosis itself adds back to this, and results in persistent atrial fibrillation. ... Impact of atrial remodeling on AF outcomes 2013-10-01 Marking the very first presentation of the 2015 AF Symposium, Prashanthan ... Left atrial pressure and pulmonary artery pressure increased, and left atrial size increased, although the animals were too big ...
Nattel S, Burstein B, Dobrev D. Atrial remodelling and atrial fibrillation: mechanisms and implications. Circ Arrhythmia ... ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes; Cardiovasc Res. 2007 Oct 26; [ ... Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circ ... ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res. 2008; 77: 35- ...
Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs ... Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation. Publication. ... atrial fibrillation, mitochondria, MCU, Ru360, SS31 Persistent URL. dx.doi.org/10.3390/cells8101202, hdl.handle.net/1765/122262 ... Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation. Cells, 8(10). ...
Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation: Data of the RACE II ( ... Is lenient rate control associated with more adverse cardiac remodeling than strict rate control in patients with atrial ... Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation: Data of the RACE II ( ... It is possible that adverse remodeling would have occurred in this group if the resting rate had been closer to 110 bpm, ...
... remodeling and fibrosis in paroxysmal atrial fibrillation (AF) using speckle tracking echocardiography (STE) based on the ... This study aimed to evaluate left atrial (LA) ... Assessment of left atrial remodeling in paroxysmal atrial ... Hong J, Gu X, An P, Luo T, Lv Q, Kang J, He Y, Hu R, Liu X, Ma C (2013) Left atrial functional remodeling in lone atrial ... Li D, Fareh S, Leung TK, Nattel S (1999) Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a ...
Atrial Heterogeneous Autonomic Neural Remodeling in Rabbits with Experimental Atrial Fibrillation and the Effect of ... inducibility of atrial fibrillation (AF), and changes of atrial autonomic neural remodeling (ANR) by rosuvastatin intervention ... Persistent rapid atrial pacing can lead to heterogeneous ANR in different parts of the rabbit atrium and may cause AF, which ... The sympathetic and parasympathetic nerves of left atrium, right atrium, and atrial septum labeled with tyrosine hydroxylase ( ...
... induced atrial structural and electrical remodeling and contributes to AF perpetuation. BACKGROUND Galectin-3 (Gal-3) mediates ... The Gal-3 inhibitor GM-CT-01 (GMCT) reduced both Gal-3 and TGF-β1-induced sheep atrial fibroblast migration and proliferation ... and also mitigated atrial dilatation, myocyte hypertrophy, fibrosis, and the expected increase in dominant frequency of ... intracardiac serum Gal-3 levels were greater in persistent than paroxysmal AF and independently predicted atrial ...
RAA = right atrial appendage; RAFW = right atrial free wall; LAA = left atrial appendage; LAFW = left atrial free wall. ... of the right atrial appendage and intra-atrial conduction time (CT) from the right atrial appendage to the lower right atrial ... 1999) Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation 100:87-95. ... 2002) Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure. Cardiovasc Res ...
LA electrical and structural remodeling leads to rhythm disorders such as atrial ectopic beats and atrial fibrillation (AF) (18 ... 2013) Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing ... Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial ... left atrial volume index. LVMI. left ventricular mass index. PAC. premature atrial contractions. proBNP. pro-brain natriuretic ...
Electrical Remodeling of the Human Atrium: Similar Effects in Patients With Chronic Atrial Fibrillation and Atrial Flutter ... Electrical Remodeling of the Human Atrium: Similar Effects in Patients With Chronic Atrial Fibrillation and Atrial Flutter ... Electrical Remodeling of the Human Atrium: Similar Effects in Patients With Chronic Atrial Fibrillation and Atrial Flutter ... and atrial flutter in patients lead to electrical remodeling of the human atrial myocardium, manifested by an abnormal relation ...
VentricularFibrosisRapid atrialAblationSustained atrial fibrillationArrhythmiaMyocytesConductionMechanismsPersistentFlutterSubstrate of atrial fibrillationAbstractExtracellular matrixElectrophysiologicalPulmonaryChronicAmerican College ofNatriuretic peptideParoxysmalMechanism for Atrial FibrillationInducibility of atrial fibrillationCharacterized in atrial fibrillationSeptumHeart FailureRisk of Atrial FibrillationElectrical remodeling inducPathophysiology of atrial fibrillationMyocardial infarctionCardiac surgeryAcuteMethodsConclusionsRight atrial ap
- Pedersen et al 6 observed that ACEI reduced the incidence of atrial fibrillation in patients with left ventricular dysfunction after acute myocardial infarction, but they did not show the underlying mechanism of their finding. (ahajournals.org)
- Ventricular dysfunction due to a rapid response to AF can cause structural remodeling, but whether AF itself directly promotes atrial fibrosis is controversial. (biomedsearch.com)
- The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. (frontiersin.org)
- Measurement: pulmonary hypertension, right ventricular hypertrophy, and pulmonary arterial and alveolar remodeling were assessed. (ovid.com)
- The effect of modulation of the autonomic nervous system by RDN on atrial electrophysiology and ventricular rate control during atrial fibrillation (AF) is unknown. (ahajournals.org)
- Subsequently, we investigated the effect of RDN on AF-induced shortening of atrial effective refractory period, AF inducibility, and ventricular rate control during AF maintained by rapid atrial pacing in 12 pigs undergoing RDN (n=7) or sham procedure (n=5). (ahajournals.org)
- Atrial fibrilla- tion ablation is relatively safe and may result in improvement of left ventricular function and quality of life. (scirp.org)
- Going back to Dr Nattel's work with substrates in AF, he continued: "This is the ventricular pacing model of heart failure, where they were able to show that in the atria there is an increased amount of atrial fibrosis associated with conduction heterogeneity, and increase of the duration of atrial fibrillation. (afsymposium.com)
- Although connexin changes are important for the ventricular arrhythmic substrate in congestive heart failure (CHF), connexin alterations during CHF-related atrial arrhythmogenic remodeling have received limited attention. (ahajournals.org)
- Left ventricular (LV) end-diastolic pressure and atrial refractory periods increased with CHF and normalized on CHF recovery. (ahajournals.org)
- 2 The atria of dogs with ventricular tachypacing-induced CHF are characterized by structural remodeling, conduction abnormalities and the ability to sustain AF. (ahajournals.org)
- We previously noted that the cessation of ventricular tachypacing, which is followed by the reversal of CHF, dissociates atrial size and function changes from structural remodeling and AF sustainability. (ahajournals.org)
- Atrial fibrillation (AF) often occurs in Brugada syndrome (BrS), and BrS patients with spontaneous AF often experience ventricular fibrillation (VF) attacks. (cdc.gov)
- Left atrial volume index (LAVI) was measured by the modified Simpson method at left ventricular end-systole using echocardiography. (cdc.gov)
- The role of the protease cathepsin A for the progression of left ventricular remote remodeling and atrial cardiomyopathy in ischemic cardiomyopathy is unknown. (onlinejacc.org)
- In rats with ventricular ischemia and reperfusion, cathepsin A is up-regulated in the left ventricular and atrial tissue remote from the infarcted area. (onlinejacc.org)
- Pharmacological inhibition of cathepsin A protease activity by SAR significantly reduces remote ventricular remodeling and atrial extracellular matrix remodeling, represented by fibrosis formation and connexin 43 lateralization. (onlinejacc.org)
- Prevention of ventricular remote remodeling and atrial cardiomyopathy by SAR increased ventricular viable myocardium and atrial emptying function reducing susceptibility to atrial fibrillation. (onlinejacc.org)
- Remote ventricular and atrial extracellular matrix remodeling may represent a promising target for pharmacological atrial fibrillation upstream therapy following myocardial infarction. (onlinejacc.org)
- After myocardial infarction, remote ventricular remodeling and atrial cardiomyopathy progress despite successful revascularization. (onlinejacc.org)
- In a rat model of ventricular ischemia/reperfusion, pharmacological inhibition of the protease activity of cathepsin A initiated at the time point of reperfusion prevented extracellular matrix remodeling in the atrium and the ventricle remote from the infarcted area. (onlinejacc.org)
- This scenario was associated with preservation of more viable ventricular myocardium and the prevention of an arrhythmogenic and functional substrate for atrial fibrillation. (onlinejacc.org)
- Remote ventricular extracellular matrix remodeling and atrial cardiomyopathy may represent a promising target for pharmacological atrial fibrillation upstream therapy following myocardial infarction. (onlinejacc.org)
- Time course of right ventricular remodeling after percutaneous atrial septal defect closure: assessment of regional deformation properties with two-dimensional strain and strain rate imaging. (docphin.com)
- Eroglu E, Cakal SD, Cakal B, Dundar C, Alici G, Ozkan B, Yazicioglu MV, Tigen K, Esen AM. Time course of right ventricular remodeling after percutaneous atrial septal defect closure: assessment of regional deformation properties with two-dimensional strain and strain rate imaging. (docphin.com)
- Quantitative assessment of the right ventricular (RV) function in atrial septal defect (ASD) patients before and after closure remains difficult. (docphin.com)
- An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. (google.es)
- The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling. (google.es)
- 3 The method of claim 1 further comprising changing the ventricular pacing site in accordance with activity level measurements reflective of metabolic demand so that the pacing site is alternated between one designed to produce hemodynamically more effective contractions when metabolic needs of the body are great to one designed for remodeling reversal when metabolic needs are less. (google.es)
- 4 . The method of claim 1 further comprising delivering pacing pulses to a plurality of ventricular sites as defined by a specified pulse output configuration and in accordance with a defined pulse output sequence which begins after the AV pacing delay interval following an atrial sense or pace. (google.es)
- Furthermore, the morphologic repercussions of NVAF, including left atrium dilation and left ventricular systolic dysfunction, as well as the presence of left atrial appendage stasis indicators, could also help refine the risk stratification. (bioportfolio.com)
- At later stages, the remodeling process proceeds to left ventricular dysfunction with the clinical consequence of the heart failure syndrome. (hindawi.com)
- Data show that nearly half of 239 glycosylation-associated genes (glycogenes) were significantly differentially expressed among neonatal and adult atrial and ventricular myocytes. (pnas.org)
- Cardiomyocyte electrical signaling was compared in control and ST8sia2 (−/−) neonatal atrial and ventricular myocytes. (pnas.org)
- A recent work showed that variable sialic acid levels attached to a single Na v isoform, Na v 1.5, were responsible for differences in channel gating observed among neonatal and adult atrial and ventricular cardiomyocytes ( 15 ). (pnas.org)
- As AF contributes to pathologic atrial and ventricular remodeling, restoration of sinus rhythm can slow or, in some cases, reverse atrial dilatation and left ventricular dysfunction. (medscape.com)
- The majority are characterized by spontaneous beating, displaying a broad range of depolarization-repolarization patterns, suggesting mixed populations of atrial and ventricular myocytes. (ptglab.com)
- Atrial and ventricular cardiomyocytes form the muscular walls of the heart (the myocardium). (ptglab.com)
- Atrial myocytes have a different ultrastructure compared to ventricular myocytes. (ptglab.com)
- The highly homogeneous atrial- and ventricular-like myocytes are extremely valuable for drug safety, cardiac evaluation, and cell therapies for heart infarction. (ptglab.com)
- Differential gene expression patterns displayed in atrial and ventricular cardiomyocytes. (ptglab.com)
- Therefore, while there are available and effective therapies for commonly occurring disorders of atrial cardiomyocytes such as atrial fibrillation, loss of ventricular cardiomyocytes resulting from myocardial infarction cannot be effectively treated. (ptglab.com)
- Recent studies show that the activation of Notch signa-ling in zebrafish atria in response to ventricle ablation is crucial for the reprogramming of atrial cardiomyocyte into ventricular cardiomyocytes. (ptglab.com)
- This study shows that zebrafish heart regeneration can be achieved by transdifferentiation of differentiated atrial cardiomyocytes into ventricular cardiomyocytes (4). (ptglab.com)
- A proper understanding of the molecular and functional differences between atrial and ventricular cardiomyocytes helps to define new strategies not only for embryonic stem cells (ESCs) applications but also to provide cellular models for the study of genetic atrial- or ventricular-related diseases (5). (ptglab.com)
- The programmed differentiation of atrial- and ventricular-like myocytes may be used to develop safe cell sources for individual treatment and personalized cardiac repair. (ptglab.com)
- Similarly, few evidence exists on right ventricular remodeling after bilateral lung transplantation for patients with pulmonary arterial hypertension (PAH). (stanford.edu)
- Objectives This study sought to evaluate the prognostic significance of left ventricular late gadolinium enhancement (LV-LGE) incidentally found in atrial fibrillation (AF) patients who undergo ablation therapy. (onlinejacc.org)
- 10 , 11 As several studies have demonstrated increased left ventricular mass and increased left atrium size in athletes, 12 it is possible that high BP may be a contributing factor 13 , 14 that may also link to the increased risk of atrial fibrillation in endurance athletes. (bmj.com)
- Since the phenotypic expression of HCM is variable, and not uncommonly includes patients with mild and localised left ventricular hypertrophy, the differential diagnosis with physiological remodelling of athlete's heart not uncommonly arises. (bmj.com)
- In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of the heart. (wikipedia.org)
- Ultimately, ventricular remodeling may result in diminished contractile (systolic) function and reduced stroke volume. (wikipedia.org)
- The term "reverse remodeling" in cardiology implies an improvement in ventricular mechanics and function following a remote injury or pathological process. (wikipedia.org)
- Dr Nattel's work has kindly demonstrated the central role of atrial fibrosis in the mechanistic method of this substrate for atrial fibrillation. (afsymposium.com)
- Whether it is with ageing, heart failure, hypertension or mitral regurgitation, these result in atrial stretch, ionic remodeling and atrial fibrosis. (afsymposium.com)
- Atrial fibrosis itself adds back to this, and results in persistent atrial fibrillation. (afsymposium.com)
- There is clear evidence to suggest that AF feeds back on itself to remodel this process, and there is even a suggestion that it may induce further atrial fibrosis. (afsymposium.com)
- He added: "We have now evaluated a number of conditions, both in the clinic and in the preclinical scenario, and it seems fairly uniform that the substrate that predisposes to atrial fibrillation is structural changes, be they interstitial fibrosis,low-voltage and scarring - the result is abnormal conduction. (afsymposium.com)
- This study aimed to evaluate left atrial (LA) remodeling and fibrosis in paroxysmal atrial fibrillation (AF) using speckle tracking echocardiography (STE) based on the findings with radiofrequency catheter ablation (RFCA) so as to predict atrial remodeling prior to ablation. (springer.com)
- (1) observed that the activation of angiotensin-converting enzyme (ACE)-dependent extracellular signal-regulated kinases (Erk1/Erk2) was involved in the mechanism of the development of atrial fibrosis in patients with AF. (onlinejacc.org)
- It is well known that architectural alterations of the atria, including atrial dilation and tissue fibrosis, are associated with atrial dysfunction (5,6) . (onlinejacc.org)
- (6) reported that electrical heterogeneity probably due to atrial fibrosis might play a critical role in the induction and promotion of AF in an arrhythmogenic substrate in the canine heart failure model. (onlinejacc.org)
- Recent data show that interstitial fibrosis can predispose to atrial conduction impairment and AF induction. (elsevier.com)
- We also describe the activation of bioactive molecules in both clinical studies and animal models to modulate MMPs and TIMPs and their effects on atrial fibrosis in AF. (elsevier.com)
- 11,12 Both structural (particularly tissue fibrosis) and connexin remodeling could contribute to CHF-associated AF. (ahajournals.org)
- However, other procedures modifying the substrate of AF, such as complex fractionated atrial electrogram ablation 3 or posterior wall debulking, 4 are required to obtain satisfying results for persistent AF patients with massive left atrial structural remodelling (LASRM) caused by massive atrial fibrosis. (bmj.com)
- Since atrial fibrosis is one of the main factors determining AF relapse after catheter ablation, evaluating atrial fibrosis in AF subjects is now of increasing importance for AF ablation strategies. (bmj.com)
- w14-16 Late gadolinium enhancement (LGE) MRI has recently been proved to be a powerful tool for detecting atrial fibrosis. (bmj.com)
- This article discusses the efficacy and implications of LGE-MRI assessment of atrial fibrosis in AF. (bmj.com)
- A manuscript on this study is now in review and should establish the scientific basis and technical feasibility of carrying out MRI-based studies of patients with AF, which CARMA has shown represent increased fibrosis in the atrial 2 and are predictive of treatment success 3,4 . (utah.edu)
- In transgenic mouse models, the activation of TGF-β1 promotes atrial fibrosis and the development of AF [ 9 ]. (plos.org)
- On the other hand, the inhibition of TGF-β1 by pirfenidone (PFD) can significantly reduce the extent of atrial fibrosis [ 10 ]. (plos.org)
- Methods and Results -In 24 dogs, the atrial effective refractory period (AERP) was measured before, during, and after rapid atrial pacing. (ahajournals.org)
- Rapid atrial pacing at 800 bpm was maintained for 180 minutes. (ahajournals.org)
- Conclusions -The inhibition of endogenous Ang II prevented AERP shortening during rapid atrial pacing. (ahajournals.org)
- Recent studies in animal models and humans have shown that atrial fibrillation induced by rapid atrial pacing itself produces shortening of the atrial effective refractory period (AERP) and reverses the normal physiological rate adaptation of refractoriness. (ahajournals.org)
- This study investigated the hypothesis that rapid atrial cardiomyocyte activation produces factors that influence atrial fibroblast proliferation and secretory functions. (biomedsearch.com)
- Persistent rapid atrial pacing can lead to heterogeneous ANR in different parts of the rabbit atrium and may cause AF, which can be reversed by rosuvastatin. (ovid.com)
- We previously reported that the blockade of angiotensin II (Ang II) prevented the electrical remodeling induced by short-term rapid atrial pacing (4) . (onlinejacc.org)
- 5 AF induces electrical remodelling primarily due to a very rapid atrial rate and associated tachycardia induced atrial remodelling. (bmj.com)
- HealthDay News - Preprocedural serum atrial natriuretic peptide (ANP) levels predict left atrial reverse remodeling after catheter ablation in patients with atrial fibrillation (AF), according to a study published online March 23 in JACC: Clinical Electrophysiology . (empr.com)
- Atrial fibrillation ablation, since it allows for therapy without the need for toxic medication, has the potential to become mainstream treatment in patients with drug refractory, symptomatic atrial fibrillation and heart failure. (scirp.org)
- Randomized studies and observational data suggest that atrial fibrillation ablation provides superior rhythm control to anti-arrhythmic drugs. (scirp.org)
- This review focuses on atrial fibrillation ablation in patients with congestive heart failure, and summarizes the results of available literature. (scirp.org)
- STE enables a noninvasive method to evaluate LA remodeling prior ablation. (springer.com)
- Nademanee K, Lockwood E, Oketani N, Gidney B (2010) Catheter ablation of atrial fibrillation guided by complex fractionated atrial electrogram mapping of atrial fibrillation substrate. (springer.com)
- Morris DA, Parwani A, Huemer M, Wutzler A, Bekfani T, Attanasio P, Friedrich K, Kuhnle Y, Haverkamp W, Boldt LH (2013) Clinical significance of the assessment of the systolic and diastolic myocardial function of the left atrium in patients with paroxysmal atrial fibrillation and low CHADS(2) index treated with catheter ablation therapy. (springer.com)
- Mirza M, Caracciolo G, Khan U, Mori N, Saha SK, Srivathsan K, Altemose G, Scott L, Sengupta P, Jahangir A (2011) Left atrial reservoir function predicts atrial fibrillation recurrence after catheter ablation: a two-dimensional speckle strain study. (springer.com)
- Plasma galectin-3 predicts clinical outcomes after catheter ablation in persistent atrial fibrillation patients without structural heart disease. (semanticscholar.org)
- Impact of biomarkers of inflammation and extracellular matrix turnover on the outcome of atrial fibrillation ablation: importance of matrix metalloproteinase-2 as a predictor of atrial fibrillation recurrence. (semanticscholar.org)
- While understanding left atrial wall thickness around PVs (PVWT) prior to catheter ablation is important, its clinical implications are not known. (yonsei.ac.kr)
- We assessed the effects of catheter ablation of PVCs on parameters of LV diastolic function and LA remodeling. (elsevier.com)
- We also compared the changes in the left atrial volumes and left atrial volume index (LAVI) after PVC ablation. (elsevier.com)
- Conclusion: Catheter ablation of PVCs improved LV diastolic function and resulted in left atrial reverse remodeling. (elsevier.com)
- PR Interval Associated Genes, Atrial Remodeling and Rhythm Outcome of Catheter Ablation of Atrial Fibrillation-A Gene-Based Analysis of GWAS Data. (cdc.gov)
- PR interval prolongation has recently been shown to associate with advanced left atrial remodeling and atrial fibrillation (AF) recurrence after catheter ablation. (cdc.gov)
- While different genome-wide association studies (GWAS) have implicated 13 loci to associate with the PR interval as an AF endophenotype their subsequent associations with AF remodeling and response to catheter ablation are unknown. (cdc.gov)
- Here, we perform a gene-based analysis of GWAS data to test the hypothesis that PR interval candidate genes also associate with left atrial remodeling and arrhythmia recurrence following AF catheter ablation. (cdc.gov)
- Of those, ITGA9 and SOX5 were significantly associated with left atrial low voltage areas and left atrial diameter and subsequently with AF recurrence after radiofrequency catheter ablation. (cdc.gov)
- This study suggests contributions of ITGA9 and SOX5 to AF remodeling expressed as PR interval prolongation, low voltage areas and left atrial dilatation and subsequently to response to catheter ablation. (cdc.gov)
- The use of ablation in the treatment of atrial fibrillation has captured the greatest attention in journals and at national meetings, and it is a major focus of this book. (springer.com)
- This guidance provides FDA's recommendations on clinical trial designs for surgical ablation devices intended for the treatment of atrial fibrillation (AF). (fda.gov)
- 9. Electrophysiological ablation for atrial tachycardia within 6 months of the operation. (bioportfolio.com)
- Dr. Vivek Reddy's talk at AF2017 highlighted advances in mapping and ablation of atrial. (afsymposium.com)
- The atrial effective refractory period and AF/AFL inducibility at baseline and after anterior right ganglionated plexi ablation were determined during left stellate ganglion stimulation or left renal sympathetic nerve stimulation in beagle dogs with or without PAH. (ahajournals.org)
- Ablation involves destroying targeted regions of the atria with the goal of either isolating triggers of spurious electrical activity or functionally separating the atrial wall into small enough segments that the putative mechanism of the arrhythmia can no longer be sustained. (utah.edu)
- In a growing number of centers, pre-ablation cardiac magnetic resonance (CMR) is performed to determine if patients are reasonable candidates for ablation therapy (4) and to provide 3-dimensional (3D) left atrial and pulmonary venous anatomy to help guide catheter navigation (5) . (onlinejacc.org)
- The purpose of this study is to determine whether irbesartan will reduce the rate of recurrent atrial high rate episodes and the development of clinical sustained atrial fibrillation in patients with hypertension and permanent pacemaker. (clinicaltrials.gov)
- OBJECTIVES To determine whether Gal-3 mediates sustained atrial fibrillation (AF)-induced atrial structural and electrical remodeling and contributes to AF perpetuation. (semanticscholar.org)
- Ausma J, Wijffels M, Thone F, Wouters L, Allessie M, Borgers M. Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. (medscape.com)
- OBJECTIVE: Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling, contributing to the progressive nature of the arrhythmia. (biomedsearch.com)
- Although a number of markers have been reported as potential predictors of paroxysmal atrial fibrillation progression towards persistent arrhythmia, their usefulness and clinical value need further validation. (scirp.org)
- Pharmacological therapy for atrial fibrillation in the heart failure population remains limited due to sub-optimal drug efficacy and a likely increased mortality due to pro-arrhythmia. (scirp.org)
- Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs electrical activation of the atria, rendering them increasingly permissive to the arrhythmia. (eur.nl)
- Postoperative atrial fibrillation (AF) is the most common arrhythmia following cardiac surgery with extracorporeal circulation. (frontiersin.org)
- Atrial fibrillation (AF) is the most common arrhythmia affecting patients after general thoracic surgery. (frontiersin.org)
- Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia in clinical practice, with a prevalence of 0.4-1% in the US population. (bmj.com)
- In recent years, growing evidence suggests an association between obstructive sleep apnea (OSA), a common sleep breathing disorder which is increasing in prevalence as the obesity epidemic surges, and atrial fibrillation (AF), the most common cardiac arrhythmia. (hindawi.com)
- Atrial fibrillation is a complex arrhythmia and its precise mechanisms remain unclear. (fda.gov)
- Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting approximately 1% of the population. (kit.edu)
- Atrial fibrillation (AF) is the most common cardiac arrhythmia and a source of significant morbidity and mortality [ 1 ]. (omicsonline.org)
- Atrial arrhythmia, which includes atrial fibrillation (AF) and atrial flutter (AFL), is common in patients with pulmonary arterial hypertension (PAH), who often have increased sympathetic nerve activity. (ahajournals.org)
- The CIBC Center continues to work in close collaboration with Dr. Nassir Marrouche and his team at the Comprehensive Arrhythmia Research and Management (CARMA) Center to advance the state of technology used for the monitoring and treatment of Atrial Fibrillation (AF). (utah.edu)
- Atrial fibrillation (AF) is the most common sustained arrhythmia and can result in heart failure (1) , stroke (2) , and death (3) . (onlinejacc.org)
- Atrial fibrillation (AF) is the most common sustained arrhythmia with debilitating consequences such as stroke and heart failure. (plos.org)
- Atrial fibrillation (AF) is the most common sustained arrhythmia disease. (jci.org)
- Transverse t-tubules are a common feature in large mammalian atrial myocytes including human. (kompetenznetz-vorhofflimmern.de)
- Objective: To determine the mechanisms underlying electrophysiological effects of palmitic (PA), stearic (SA) and oleic (OA) FFAs on sheep atrial myocytes. (umn.edu)
- Methods: We used electrophysiological techniques, numerical simulations, biochemistry and optical imaging to examine the effects of acutely (≤ 15 min), short-term (4-6 hour) or 24-hour application of individual FFAs (10 μM) on isolated ovine left atrial myocytes (LAMs). (umn.edu)
- Results: Acute and short-term incubation in FFAs resulted in no differences in passive or active properties of isolated left atrial myocytes (LAMs). (umn.edu)
- Conclusions: SA disrupts t-tubular architecture and remodels properties of membrane ionic currents in sheep atrial myocytes, with potential implications in arrhythmogenesis. (umn.edu)
- The perpetuation of AF and continuous electrophysiological disturbance (electrical remodelling) in atrial myocytes ultimately cause cell apoptosis, and then fibrotic tissue replaces the dead atrial myocytes. (bmj.com)
- Action potential waveforms and gating of less sialylated voltage-gated Na + channels were altered consistently in ST8sia2 (−/−) atrial myocytes. (pnas.org)
- In this issue of the JCI , Greiser and coworkers discovered that atrial remodeling in response to sustained tachycardia silences Ca 2+ signaling in isolated rabbit and human atrial myocytes. (jci.org)
- Besides, reduced expression of V1 mysoin and L-type calcium channels on cardiac myocytes are also thought to cause cardiac remodelling. (wikipedia.org)
- The AF duration, atrial effective refractory period (AERP) at four sites in the RA, and intra-atrial conduction time (CT) from the RA appendage to the other three sites were measured every week. (onlinejacc.org)
- CHF causes atrial connexin changes, but these are not essential for CHF-related conduction disturbances and AF promotion, which are rather related primarily to fibrotic interruption of muscle bundle continuity. (ahajournals.org)
- We therefore exploited CHF reversal to assess the reversibility of atrial connexin alterations and evaluate their contribution to CHF-related conduction disturbances and AF maintenance. (ahajournals.org)
- Nowadays echocardiography is the mainstream technique for detecting LASRM which may cause left atrial (LA) volume expansion and atrial conduction slowing and heterogeneity. (bmj.com)
- Intra-atrial conduction time (CT) was defined as the interval from the stimulus at the high right atrium to atrial deflection at the distal portion of the coronary sinus. (cdc.gov)
- These findings are consistent with recent observations that AF per se may cause ECM remodeling, and have potentially important consequences for understanding and preventing the mechanisms underlying AF progression. (biomedsearch.com)
- Marking the very first presentation of the 2015 AF Symposium, Prashanthan Sanders from the Royal Adelaide Hospital, Australia, kickstarted proceedings on Thursday morning with an exploration of the mechanisms of atrial remodeling and their impact of AF outcomes. (afsymposium.com)
- Considering previous observations, we hypothesized that structural abnormalities caused by an activated renin-angiotensin system during chronic atrial activation might participate in the mechanisms of AF maintenance. (onlinejacc.org)
- Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. (semanticscholar.org)
- Background: Atrial electrical remodeling (AER) is one of the mechanisms by which atrial fibrillation (AF) begets AF. (elsevier.com)
- Lin, CS & Pan, CH 2008, ' Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation ', Cellular and Molecular Life Sciences , vol. 65, no. 10, pp. 1489-1508. (elsevier.com)
- Congestive heart failure (CHF) predisposes to atrial fibrillation (AF), although the underlying mechanisms remain incompletely understood. (ahajournals.org)
- Here, we review the diverse transcriptional, post-transcriptional, post-translational and epigenetic mechanisms contributing to regulating the expression, distribution and remodeling of cardiac K + channels under physiological and pathological conditions. (pubmedcentralcanada.ca)
- Here, the factors contributing to the diverse properties and functional roles of myocardial K + channels are reviewed, and the molecular mechanisms contributing to the physiological regulation and pathological remodeling of myocardial K + channels are discussed. (pubmedcentralcanada.ca)
- However, the underlying regulatory mechanisms of atrial remodeling remain unclear. (nctu.edu.tw)
- The present review outlines the molecular and biochemical mechanisms which play a role in muscular atrophy, hypertrophy, and remodeling. (degruyter.com)
- This so-called myocardial remodeling initially enables compensatory mechanisms to maintain cardiac function despite the persisting pathologic stimuli. (hindawi.com)
- Dr Fabritz's main interests are in molecular and translational cardiology, mechanisms of heart disease, cardiomyopathies and arrhythmias, sudden death, and atrial fibrillation. (nature.com)
- We know that AF is a progressive disease that most patients go from paroxysmal to persistent, and then to permanent atrial fibrillation," he began. (afsymposium.com)
- If an individual has a few risk factors, the incidence of persistent atrial fibrillation is much lower than if you have a greater number of risk factors, in which case it is more likely that these individuals will progress to persistent atrial fibrillation. (afsymposium.com)
- Lenient rate control does not promote adverse cardiac remodeling in patients with persistent AF. (acc.org)
- Effects of persistent atrial fibrillation on serum galectin-3 levels. (semanticscholar.org)
- Experimental studies in goats and isolated human atrial tissue have shown that prolonged AF leads to persistent shortening of atrial refractoriness, a phenomenon referred to as electrical remodeling and which helps to explain why AF begets AF. (onlinejacc.org)
- We investigated the concentrations of IL-33, its soluble ST2 receptors, and high-sensitivity C-reactive protein levels (hsCRP) in the sera of 92 patients with persistent atrial fibrillation, and 68 controls. (omicsonline.org)
- Electrophysiological characteristics of the human atria after cardioversion of persistent atrial fibrillation. (medscape.com)
- atrial septal defects , atrioseptal defects congenital anomalies in which there is persistent patency of the atrial septum, owing to failure of the ostium primum or ostium secundum. (thefreedictionary.com)
- Using monophasic action potential recordings at two right atrial sites simultaneously, we determined in 7 patients with chronic AF and 13 with chronic atrial flutter (3 weeks to 3 years in duration) the relation between paced cycle length and APD at 90% repolarization (APD90) 15 to 30 min after conversion to sinus rhythm. (onlinejacc.org)
- There were no significant differences between patients with cardioversion from atrial flutter and those with cardioversion from AF. (onlinejacc.org)
- APD90 at a steady state cycle length of 600 ms showed no significant correlation with the duration of previous AF or atrial flutter. (onlinejacc.org)
- AF and atrial flutter lead to marked, quantitatively similar decreases in the right atrial APD during steady state pacing and extrastimulation a considerable time after cardioversion. (onlinejacc.org)
- These data confirm that both AF and atrial flutter lead to electrical remodeling in the human atrium, with a preponderance at longer cycle lengths. (onlinejacc.org)
- heart , atrial fibrillation (AF) and atrial flutter (Aflut), occur frequently after most types of cardiac surgeries. (bioportfolio.com)
- Voltage maps of the atria demonstrated large areas of low voltage, increased areas of scarring and a more complex electrogram in a patient with heart failure, when compared to control… This has become what is a common feature for the substrate of atrial fibrillation. (afsymposium.com)
- Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins. (semanticscholar.org)
- Hypoxic stress upsets the balance in the normal relationships between mitogenic and growth inhibiting pathways in lung, resulting in pulmonary vascular remodeling characterized by hyperplasia of pulmonary arterial smooth muscle cells (PASMCs) and fibroblasts and enhanced deposition of extracellular matrix. (ovid.com)
- BACKGROUND Galectin-3 (Gal-3) mediates extracellular matrix remodeling in heart failure, but its role in AF progression remains unexplored. (semanticscholar.org)
- The interplay between cardiac matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of MMPs (TIMPs), is thought to be critical in atrial extracellular matrix (ECM) metabolism. (elsevier.com)
- However, LV remodeling due to structural and functional changes in the extracellular matrix (ECM) often progresses even following successful revascularization and is the most common reason for heart failure after myocardial infarction (3,4) . (onlinejacc.org)
- Myocardial remodeling is a complex and heterogeneous process involving cardiac myocyte alterations, activation of fibroblasts, and transdifferentiation to myofibroblasts (MyoFb) as well as a dynamic functional and structural reorganization of the cardiac extracellular matrix (cECM) [ 2 , 4 - 6 ]. (hindawi.com)
- Atrial natriuretic peptide (ANP) reduces pulmonary vascular resistance and attenuates hypoxia-induced pulmonary hypertension in vivo and PASMC proliferation and collagen synthesis in vitro. (ovid.com)
- The current study utilized an ANP null mouse model (Nppa−/−) to test the hypothesis that ANP modulates the pulmonary vascular and alveolar remodeling response to normobaric hypoxic stress. (ovid.com)
- The contribution of progressive left atrial (LA) enlargement to elevated pulmonary capillary wedge pressure (PCWP) in patients with WHO Group II pulmonary hypertension (PH) has not been well studied. (springer.com)
- PURPOSE: Circumferential pulmonary (PV) vein isolation (CPVI) is the most important treatment strategy for atrial fibrillation (AF). (yonsei.ac.kr)
- 11 With respect to repetitive activity in small atrial areas, however, Mandapati et al 12 demonstrated in healthy sheep hearts that repetitive reentry in the posterior left atrium near or at pulmonary vein ostia can produce microreentrant sources for AF. (ahajournals.org)
- She is currently working on studies on cardiac remodeling pulmonary hypertension with the goal of understanding the influence of inflammation and finding early biomarkers of remodeling. (stanford.edu)
- PhD, Universite Paris Sud - Paris Saclay (France), Right Heart Remodeling in Pulmonary Hypertension: from deep phenotyping to proteomics profiling. (stanford.edu)
- Pathologic pressure mismatches between the pulmonary and systemic circulation guide compensatory remodeling of the left and right ventricles. (wikipedia.org)
- Atrial Remodeling in Pregnant Hypertensive Women: Comparison between Chronic and Gestational Hypertension. (biomedsearch.com)
- CONCLUSION: Patients with chronic hypertension showed a more marked increased of LA volumes compared to gestational hypertension due to a remodeling of atrial shape as effect of chronic overload. (biomedsearch.com)
- Hoit BD, Shao Y, Gabel M. Left atrial systolic and diastolic function accompanying chronic rapid pacing-induced atrial failure. (springer.com)
- Objectives The purpose of the present study was to evaluate the effect of angiotensin II type 1 receptor (AT1R) antagonist on chronic structural remodeling in atrial fibrillation (AF). (onlinejacc.org)
- However, the effect of candesartan on chronic structural remodeling in AF is unclear. (onlinejacc.org)
- Chronic hypertension, congenital heart disease with intracardiac shunting, and valvular heart disease may also lead to remodeling. (wikipedia.org)
- 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. (medscape.com)
- ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation). (medscape.com)
- In 2014, the American Heart Association/American College of Cardiology/Heart Rhythm Society (AHA/ACC/HRS) released updated guidelines for the management of patients with atrial fibrillation (AF). (medscape.com)
- In addition, there is a greater inducibility of atrial fibrillation. (afsymposium.com)
- The study aimed to observe the effects of pacing on the atrial effective refractory period (AERP), inducibility of atrial fibrillation (AF), and changes of atrial autonomic neural remodeling (ANR) by rosuvastatin intervention on the acute model of rapid-pacing-induced AF. (ovid.com)
- The sympathetic and parasympathetic nerves of left atrium, right atrium, and atrial septum labeled with tyrosine hydroxylase (TH) and choline acetyl transferase (ChAT) were detected by immunohistochemistry and Western blot. (ovid.com)
- Segments included 4 regions around each PV, and the LA posterior wall and inter-atrial septum. (biomedcentral.com)
- 1999) Promotion of atrial fibrillation by heart failure in dogs Atrial remodeling of a different sort. (scirp.org)
- Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. (springer.com)
- The cardiac atria are chambers of active remodeling and dynamic collagen turnover during evolving heart failure. (springer.com)
- It is possible that adverse remodeling would have occurred in this group if the resting rate had been closer to 110 bpm, particularly in patients with heart failure. (acc.org)
- Background: Epicardial adiposity and plasma levels of free fatty acids (FFAs) are elevated in atrial fibrillation, heart failure and obesity, with potentially detrimental effects on myocardial function. (umn.edu)
- Model of minimum degree of complexity of ionic and structural remodeling that enhances the initiation and maintenance of atrial fibrillation in 2 common AF conditions (heart failure and aging). (ahajournals.org)
- Patients with Atrial Fibrillation (AF) have an excessive risk of arterial thromboembolic disease and heart failure, resulting in higher rates of cardiovascular and all-cause mortality in this population. (bioportfolio.com)
- In nearly all cardiac pathologies including hypertrophy, heart failure, and long QT syndrome (LQTS), at least one type of remodeling occurs ( 3 , 6 ). (pnas.org)
- By maintaining the atrial contribution to cardiac output, symptoms of heart failure and overall quality of life can improve. (medscape.com)
- Evidence of postoperative right heart remodeling are contrasted according to the studies and determinants of right heart failure are still unclear. (stanford.edu)
- A common scenario for remodeling is after myocardial infarction. (wikipedia.org)
- The initial remodeling phase after a myocardial infarction results in repair of the necrotic area and myocardial scarring that may, to some extent, be considered beneficial since there is an improvement in or maintenance of LV function and cardiac output. (wikipedia.org)
- Methods and Results- The miRNA transcriptome was analyzed by microarray and verified by real-time reverse-transcription polymerase chain reaction with left atrial samples from dogs with AF established by right atrial tachypacing for 8 weeks and from human atrial samples from AF patients with rheumatic heart disease. (ahajournals.org)
- METHODS: Cultured canine atrial fibroblasts were treated with medium from rapidly-paced atrial cardiomyocytes, non-paced cardiomyocytes and cardiomyocyte-pacing medium only, and analyzed by [(3)H]thymidine incorporation, Western blot and real-time RT-PCR. (biomedsearch.com)
- A pacing lead introduced into the femoral vein was placed in the right atrial appendage to measure the AERP. (ahajournals.org)
- To minimize confounding effects caused by electrode polarization, all refractory period measurements were made with the pacing lead, which was not used for high-frequency pacing and was positively affixed to the right atrial appendage. (ahajournals.org)