Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.Benzimidazoles: Compounds with a BENZENE fused to IMIDAZOLES.TetrazolesCaptopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Angiotensin II Type 1 Receptor Blockers: Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.1-Sarcosine-8-Isoleucine Angiotensin II: An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR.Tachycardia, Ectopic Atrial: Abnormally rapid heartbeats originating from one or more automatic foci (nonsinus pacemakers) in the HEART ATRIUM but away from the SINOATRIAL NODE. Unlike the reentry mechanism, automatic tachycardia speeds up and slows down gradually. The episode is characterized by a HEART RATE between 135 to less than 200 beats per minute and lasting 30 seconds or longer.Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.Tachycardia, Supraventricular: A generic expression for any tachycardia that originates above the BUNDLE OF HIS.Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Catheter Ablation: Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.Aortic Valve Stenosis: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.Heart Valve Prosthesis Implantation: Surgical insertion of synthetic material to repair injured or diseased heart valves.Ventricular Remodeling: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.Aortic Valve: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.Heart Atria: The chambers of the heart, to which the BLOOD returns from the circulation.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.Sick Sinus Syndrome: A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Pacemaker, Artificial: A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).Arrhythmia, Sinus: Irregular HEART RATE caused by abnormal function of the SINOATRIAL NODE. It is characterized by a greater than 10% change between the maximum and the minimum sinus cycle length or 120 milliseconds.Sinoatrial Node: The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).Asymptomatic Diseases: Diseases that do not exhibit symptoms.Pulmonary Veins: The veins that return the oxygenated blood from the lungs to the left atrium of the heart.Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.National Institute of General Medical Sciences (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic biomedical research that is not targeted to specific diseases and funds studies on genes, proteins, and cells, as well as on fundamental processes like communication within and between cells and metabolism. It was established in 1962.Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Atmosphere: The gaseous envelope surrounding a planet or similar body. (From Random House Unabridged Dictionary, 2d ed)Endoplasmic Reticulum: A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Membrane Potential, Mitochondrial: The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.Endoplasmic Reticulum Stress: Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.Venturicidins: Toxic substances isolated from various strains of Streptomyces. They are 20-membered macrolides that inhibit oxidative phosphorylation and mitochondrial ATPases. Venturicidins A and B are glycosides. Used mainly as tools in the study of mitochondrial function.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Rhodospirillaceae: A family of phototrophic bacteria, in the order Rhodospirillales, isolated from stagnant water and mud.Hydroponics: A technique for growing plants in culture solutions rather than in soil. The roots are immersed in an aerated solution containing the correct proportions of essential mineral salts. (From Concise Dictionary of Biology, 1990)Musa: A plant genus of the family Musaceae, order Zingiberales, subclass Zingiberidae, class Liliopsida.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Connexin 43: A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.Connexins: A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.JNK Mitogen-Activated Protein Kinases: A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.Gap Junctions: Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.Mitogen-Activated Protein Kinases: A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Atrial Appendage: Ear-shaped appendage of either atrium of the heart. (Dorland, 28th ed)Echocardiography, Transesophageal: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.Atrial Function, Left: The hemodynamic and electrophysiological action of the LEFT ATRIUM.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Thromboembolism: Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.

Pre-procedural prediction of termination of persistent atrial fibrillation by catheter ablation as an indicator of reverse remodeling of the left atrium. (1/11)

BACKGROUND: The pre-procedural prediction of atrial fibrillation (AF) termination by catheter ablation in patients with persistent AF has not been evaluated fully. The aim of this study was to evaluate the pre-procedural predictors of persistent AF termination by ablation associated with the possibility of reverse remodeling of the left atrium (LA). METHODS AND RESULTS: Seventy consecutive patients (mean age, 62+/-8 years) with persistent or long-standing persistent AF underwent ablation. They were divided into 2 groups: those with AF terminated by ablation (n=14; group 1) and those with AF terminated by cardioversion after ablation (n=56; group 2). The left atrial appendage (LAA) contraction velocity determined on transesophageal echocardiography was significantly decreased in group 2 as compared to group 1 (P<0.001). Kaplan-Meier analysis showed that the group 1 patients had a higher AF-free survival rate than those in group 2 during 12+/-4.1 months of follow-up (P=0.048). The LA reverse remodeling ratio, given as the volume difference between before and 3 months after ablation in group 1, was significantly greater after ablation than that in group 2 (25.8+/-13% vs. 15.0+/-15%, P=0.015). Multivariate logistic regression analysis indicated that the LAA contraction velocity was an independent predictor of persistent AF termination by ablation (P=0.018). CONCLUSIONS: The LAA contraction velocity was the only non-invasive pre-procedural predictor of persistent AF termination by ablation, indicating the possibility of reverse remodeling of the LA.  (+info)

Changes in microRNAs expression are involved in age-related atrial structural remodeling and atrial fibrillation. (2/11)

BACKGROUND: Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been implicated in the aging process and in the regulation of extracellular matrix proteins. However, their role in age-related cardiac remodeling and atrial fibrillation (AF) was not well understood. The present study was designed to decipher molecular mechanisms underlying age-related atrial structural remodeling and AF. METHODS: Three groups of dogs were studied: adult and aged dogs in sinus rhythm and with persistent AF induced by rapid atrial pacing. The expressions of microRNAs were measured by quantitative real-time polymerase chain reaction. Pathohistological and ultrastructural changes were tested by light and electron microscopy. Apoptosis index of myocytes was detected by TUNEL. RESULTS: Samples of atrial tissue showed the abnormal pathohistological and ultrastructural changes, the accelerated fibrosis, and apoptosis with aging and/or in AF dogs. Compared to the adult group, the expressions of microRNAs-21 and -29 were significantly increased, whereas the expressions of microRNAs-1 and -133 showed obvious downregulation tendency in the aged group. Compared to the aged group, the expressions of microRNAs-1, -21, and -29 was significantly increased in the old group in AF; contrastingly, the expressions of microRNA-133 showed obvious downregulation tendency. CONCLUSION: These multiple aberrantly expressed microRNAs may be responsible for modulating the transition from adaptation to pathological atrial remodeling with aging and/or in AF.  (+info)

An Angiotensin receptor blocker prevents arrhythmogenic left atrial remodeling in a rat post myocardial infarction induced heart failure model. (3/11)

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Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing. (4/11)

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MicroRNAs in pulmonary arterial remodeling. (5/11)

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Left atrial endocardial fibrosis and intra-atrial thrombosis - landmarks of left atrial remodeling in rats with spontaneous atrial tachyarrhythmias. (6/11)

INTRODUCTION: Histological abnormalities are common findings in the left atria (LA) of atrial fibrillation (AF) patients. We aimed to assess LA histological abnormalities in our model of spontaneous atrial tachyarrhythmias in rats. MATERIALS AND METHODS: LA sampling was performed in 12 spontaneously hypertensive rats (SHRs) and eight age-matched Wistar-Kyoto (WKY) rats. Tissue sections were stained with Masson's trichrome and Hematoxylin-Eosin-Safran and examined with a light microscope. A 0 to 3 scoring system was used to quantify the severity of LA structural abnormalities. LA von Willebrand factor (vWF) content was also assessed using immunohistochemical staining. RESULTS: In six of the eight SHRs, LA fibrosis, inflammatory infiltrates, and myocyte necrosis of varying grades of severity were observed. The most frequent feature was endocardial fibrosis, which was observed in six SHRs and in none of the WKY rats. Intra-atrial thrombosis was found in three SHRs and in none of the WKY rats. The intensity of vWF-related fluorescence was higher in the atrial endocardium of SHRs compared to age-matched WKY rats. CONCLUSIONS: Our findings reinforce the role of LA structural abnormalities in atrial arrhythmogenicity. However, two SHRs did not present LA histological abnormalities despite the presence of arrhythmias. This finding suggests that the LA remodeling-atrial tachyarrhythmia relationship could be highly nonlinear and that atrial fibrosis is more likely to be a facilitator of atrial arrhythmogenicity, rather than a prerequisite. We also provide evidence that intra-atrial thrombosis accompanies LA structural remodeling in arrhythmic rats. Increased endocardial platelet adhesion molecule vWF could contribute to this increased thrombogenicity.  (+info)

Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation. (7/11)

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Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing. (8/11)

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AF is very rare in children so it would be no surprise if theres not much out there. If you want this question to remain open, you should edit it and add some of the information youve found so far because MedSci requires questions to demonstrate at least some level of prior research. - Carey Gregory♦ Nov 9 18 at 19:49 ...
Tokyo ― Terumo Corporation (TSE: 4543 Section 1) announced CE marking for the commercial sale of the Iberis™ Renal Sympathetic Denervation System, which the company has consigned product development to Shanghai AngioCare Medical Technology Co., Ltd. (hereinafter AngioCare) (Representative: Philip Wang), a Chinese company in renal sympathetic denervation technology for resistant hypertension treatment.. In December, 2012, Terumo formed a strategic alliance with AngioCare. Furthermore, the company has consigned product development to AngioCare and acquired the exclusive distribution rights for its renal sympathetic denervation technology on the global market.. Sales of Iberis in Europe will be commenced with its launch at the worlds leading cardiovascular intervention course, EuroPCR to be held in France in May, 2013.. Terumo aims to expand its renal sympathetic denervation business by launching Iberis in Asian and Latin American countries where the CE marked product is allowed for ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
The objective of this trial is to determine the efficacy and safety of adjunctive catheter-based renal sympathetic denervation (RSDN) in the primary prevention of ICD therapy in patients with ischemic or non-ischemic ventricular dysfunction, who are to receive an ICD for either i) secondary prevention, or ii) primary prevention + inducible VT by programmed ventricular stimulation at the time of ICD implantation. These patients will be randomized to ICD alone or ICD + RSDN ...
The objective of this trial is to determine the efficacy and safety of adjunctive catheter-based renal sympathetic denervation (RSDN) in the primary prevention of ICD therapy in patients with ischemic or non-ischemic ventricular dysfunction, who are to receive an ICD for either i) secondary prevention, or ii) primary prevention + inducible VT by programmed ventricular stimulation at the time of ICD implantation. These patients will be randomized to ICD alone or ICD + RSDN ...
Acupuncture Points location, description, functions, picture, acupuncture point chart. Look for specific acupuncture points and their uses. See pictures, charts and learn common uses and location.
TY - JOUR. T1 - Measurement of funny current (I(f)) channel mRNA in human atrial tissue. T2 - Correlation with left atrial filling pressure and atrial fibrillation. AU - Lai, Ling Ping. AU - Su, Ming Jai. AU - Lin, Jiunn Lee. AU - Tsai, Chang Her. AU - Lin, Fang Yue. AU - Chen, Yih Sharng. AU - Hwang, Juey Jen. AU - Stephen Huang, Shoei K.. AU - Tseng, Yung Zu. AU - Lien, Wen Pin. PY - 1999/1/1. Y1 - 1999/1/1. N2 - Introduction: The funny current (I(f)) contributes to phase IV spontaneous depolarization in cardiac pacemaker tissue. Enhanced I(f) activity in myocardial tissue may lead to increased automaticity and therefore tachyarrhythmia. We measured the amount of I(f) activity in the messenger ribonucleic acid (mRNA) in human atrial tissue and correlated the mRNA amount to left atrial filling pressure and atrial fibrillation (AF). Methods and Results: A total of 34 patients undergoing open heart surgery were included (15 men and 19 women, aged 55 ± 10 years). Atrial tissue was obtained from ...
This MATLAB function displays the vectors specified by U and V, where U contains the x components as relative coordinates, and V contains the y components as relative coordinates.
Full nutritional breakdown of the calories in Microwave Peanut Brittle based on the calories and nutrition in each ingredient, including Peanuts, dry-roasted, Granulated Sugar, Light Corn Syrup, Butter, salted, Vanilla Extract and the other ingredients in this recipe.
In this monograph Dr. Wenger has reviewed some 800 cases of endocardial fibro-elastosis from the literature and has reported 40 cases of his own. The result of his labors is a useful collection of data and references dealing with this poorly understood disorder. The author distinguishes five "types" of endocardial fibrotic change and divides his material therefore into these five major categories: (1) Endocardial fibro-elastosis, (2) Endomyocardial fibrosis, (3) Endocarditis parietalis fibroplastica, (4) Endocardial changes in the carcinoid syndrome, and (5) Secondary patchy endocardial fibrosis of the adult.. Irrespective of the validity of this division, these headings allow the author ...
Blood flow measurement using an improved surface integration of velocity vectors (SIVV) technique was tested in in vitro phantoms. SIVV was compared with true flow (12-116 mL/s) in a steady-state model using two angles of insonation (45 degrees and 60 degrees ) and two vessel sizes (internal diameter = 11 and 19 mm). Repeatability of the method was tested at various flow rates for each angle of insonation and vessel. In a univentricular pulsatile model, SIVV flow measured at the mitral inlet was compared to true flow (29-61 mL/s). Correlation was excellent for the 19-mm vessel (r(2)= 0.99). There was a systematic bias but close limits of agreement (mean +/- 2 SD = -24.1% +/- 7.6% at 45 degrees; +16.4% +/- 11.0% at 60 degrees ). Using the 11-mm vessel, a quadratic relationship was demonstrated between between SIVV and true flow (r(2) = 0.98-0.99), regardless of the angle of insonation. In the pulsatile system, good agreement and correlation were shown (r(2) = 0.94, mean +/- 2 SD = -4.7 +/- ...
In a preferred embodiment, drugs having heretofore unknown pharmacological properties which are useful in the medicinal therapy of fibrotic disease for the reparation and prevention of fibrotic lesional tissues, such drugs including as the active ingredient 5-methyl-1-phenyl-2-(1H)-pyridone. The pharmaceutical composition of this invention is novel as an anti-fibrotic drug, namely, as an agent for treating fibrosis. Any existing compounds have not been shown to be effective for the reparation and prevention of fibrotic lesions.
You are definitely on the right track. You can continue by first combining terms on the velocity so that you have the results in the form ai+bj+ck. The rate at which work is being done at any time is equal to the force F dotted with the velocity vector. Evaluate this dot product, and then integrate with respect to t. What is the formula for the change in KE in terms of the initial and the final velocity ...
Symple Surgical Inc., (SSI) is a developer of novel ablation technologies using controlled Microwave Energy. Symple Surgical innovation is for the treatment of resistant hypertension via renal sympathetic denervation. The DirectAblate Catheter delivers microwave energy to the depth-specific location of the sympathetic nerves while minimizing thermal exposure to non-targeted areas. Offices located in Northern California and Flagstaff, AZ.
well, I found an equation of a= (v^2)/2 i, which gave an acceleration of a = 8 m/s i. I dont understand how this equation was derived. Although, now that I have actually thought about this, the acceleration vector around a curve or a circle always points toward the center of the circle and the velocity vector is always tangent to the point on the curve, so I understand how the acceleration vector is i and the velocity vector is j for x=-2,y=0. The only problem I have is the equation I came across ...
A method of controlling scar formation in humans by applying a force to tissue in an amount to create a wound; applying a lathyrogenic agent to the wound; forming the wound into a predetermined stationary or moveable beneficial configuration; and maintaining the wound in the predetermined configuration and in contact with lathyrogenic agent during healing.
Session VI - Recognizing Grey - controversial and ambiguous issues in cardiology. Chairpersons: J. J. Bax (Leiden, NL). B. Khandheria (Milwaukee, WI USA). 11:00 a.m. K. Narkiewicz (Gdańsk, PL). Hidden mechanisms of arterial hypertension. 11:30 a.m. J. J. Bax (Leiden, NL). Imaging to select patients for TAVI. 12:00 p.m. S. Q. Allaqaband (Milwaukee, WI USA). Interventions in structural heart disease. 12:30 p.m. F. Mahfoud (Homburg, D). Renal sympathetic denervation: should we go beyond resistant hypertension?. 01:00 p.m. M. Miglinas (Vilnius, LT). Blood pressure lowering and target organ protection: coherent or diverging effects?. 01:30 p.m. Concluding Remarks. Remigijus Zaliunas (Kaunas, LT). Rimvydas Slapikas (Kaunas, LT). Germanas Marinskis (Vilnius, LT). Zaneta Petrulioniene (Vilnius, LT ...
carbon dioxide angiography, chronic kidney disease (CKD), contrast nephropathy, renal sympathetic denervation, uncontrolled hypertension Background
Definition and Overview A keloid is a skin disorder subsequent from an abnormal or unnecessary development of scar tissue after a deep injury or wound has healed. It is a dermal fibrotic lesion ...
Study Flashcards On 6-04 msk/derm/vasc at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Identification of discrete surfaces. A: whole cardiac mesh [including atrial tissue] produced from Tetgen showing the tagged tetrahedral elements: myocardium (g
Since 2012, several cases of renal stenosis after renal denervation have been reported, demonstrating a wide spectrum of clinical presentation, but presenting recurrent hypertension as most relevant finding (1).. In the previous trials HTN-1 (Symplicity Renal Denervation in Patient With Refractory Hypertension) (2) and EnligHTN-I (Safety and Efficacy of Study of Renal Artery Ablation in Resistant Hypertension Patients) (3), renal artery stenosis had been attributed mainly to pre-existing artery stenosis worsening and not to a de novo procedure-related adverse event. The increasing reports of the last call into question the safety of this procedure and point to this complication as a possible cause of therapy ineffectiveness. ...
Methods and Results: We used a human atrial tissue model in heart failure and simulated propagation and spiral wave reentry with and without regionally proliferated fibroblasts. Coupling of fibroblasts to atrial myocytes resulted in shorter action potential duration, slower conduction velocity, and lower excitability. Consequently, heterogeneous fibroblast proliferation in the myocardial sheet resulted in frequent spiral wave breakups, and the bipolar electrograms recorded at the fibroblast proliferation area exhibited CFAEs. The simulations demonstrated that ablation targeting such fibroblast-derived CFAEs terminated AF, resulting from the ablation site transiently pinning the spiral wave and then pushing it out of the fibroblast proliferation area. CFAEs could not be attributed to collagen accumulation alone.. ...
Coarctation of the aorta is a narrowing of the descending aorta, which is typically located at the insertion of the ductus arteriosus just distal to the left subclavian artery (). This defect generally results in left ventricular pressure overload.Th
23] Mandache E, Gherghiceanu M, Macarie C, et al., Telocytes in human isolated atrial amyloidosis: ultrastructural remodelling ... tissue homoeostasis and remodelling/renewal [29]. Figure 9. Human mammary gland stroma: TEM; original magnification 9,100x. A: ...
"Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling". The Journal of ... Ablation of sarcolipin increases atrial Ca2+ transient amplitudes and enhanced atrial contractility. Furthermore, atria from ... "Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility". Proceedings of the National ...
"Increased Ca buffering underpins remodelling of Ca(2+) handling in old sheep atrial myocytes". The Journal of Physiology. 595 ( ... Calcium buffering within atrial myocytes is affected by ageing in large animal models, elevating sarcoplasmic reticulum calcium ... content, which could potentially contribute towards a tendency to atrial fibrillation. Neuroscience portal Calcium channel ...
"Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure". ... "Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice". The Journal of Clinical Investigation. 120 ( ...
"Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovasc. Res. 83 (3): ...
This suggests that budiodarone may promote atrial re-modelling to improve malfunctioning ion channels that once potentiated ... in patients with paroxysmal atrial fibrillation and pacemakers with atrial fibrillation data logging capabilities [abstract]. ... Amiodarone to prevent recurrence of atrial fibrillation. N Engl J Med. 2000;342:913-920 Singh, B.N., et al. Amiodarone versus ... A decrease in heart rate reduces the risk of atrial fibrillation. Preliminary trials of budiodarone have administered the drug ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4 (2): 129-37. doi:10.1159/000381543. PMC ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4: 129-37. doi:10.1159/000381543. PMC ...
5-Diiodothyronine and Correlates with Atrial Remodeling". European Thyroid Journal. 4: 129-37. doi:10.1159/000381543. PMC ...
2009). "Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines". Cardiovasc Res. ... of miR-590 by nicotine has been found to play a key part in the generation of atrial fibrosis by atrial structural remodelling ...
"Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs". ... In a porcine model of left atrial remodeling following mitral regurgitation, VLC-2 was shown to be upregulated. Human ALC-2 is ... Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans ... In a canine model of atrial fibrillation, decreased atrial contractility was associated with decreased ALC-2 and myosin binding ...
pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and ... Throughout life, the cardiac collagen skeleton is remodeled. Where collagen is diminished by age, calcium is often deposited, ... venae cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve ... The AV node is the only electrical conduit from the atria to the ventricles through the cardiac skeleton, which is why atrial ...
The recently remodeled atrium looks better than ever with its new and spacious gardens that are home to different types of ... Its pink stone facade has a tower composed of three bodies; there are cross atrial figures of the Passion of the Christ and of ...
... selectively increases atrial refractory period by 22% in dogs with atrial tachycardia induced electrical remodeling. ... During atrial fibrillation this process becomes chaotic and the atrial depolarization occurs faster than it should causing the ... A recognized atrial selective drug target is Kv1.5, which is found in atria but not in ventricles. Kv1.5 carries the ultra ... Atrial Fibrillation (AF) is an arrhythmia that occurs in 1-2% of the general population. AF is linked to several cardiac causes ...
It is also believed that angiotensin directly affects cardiac remodeling, and blocking its activity can thereby slow the ... Glucocorticoids induce a potent diuresis in heart failure because they could improve renal responsiveness to atrial natriuretic ... It is also thought that catecholamines and other sympathomimetics have an effect on cardiac remodeling, and blocking their ... These commonly involve surgical left ventricular remodeling. The aim of the procedures is to reduce the ventricle diameter ( ...
One reason for this may be that once the heart has undergone atrial remodeling as in the case of chronic atrial fibrillation ... AF therefore have an increased chance of success with an ablation since their heart has not undergone atrial remodeling yet. ... Risks of catheter ablation for atrial fibrillation include, but are not limited to: stroke, esophageal injury and death. ... Long-term single procedure efficacy of catheter ablation of atrial fibrillation. J Interv Card Electrophysiol (2006) 15:145-155 ...
For example, MMP9 appears to be involved in the remodeling associated with malignant glioma neovascularization. It is also a ... MMP9 levels increase with the progression of idiopathic atrial fibrillation. MMP9 has been found to be associated with the ... Gelatinase B plays a central role in tumor progression, from angiogenesis, to stromal remodeling, and ultimately metastasis. ... which are key effectors of ECM remodeling. MMP9, along with elastase, appears to be a regulatory factor in neutrophil migration ...
"2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial ... Left ventricular hypertrophy and left ventricular remodeling Diminished coronary flow reserve and silent myocardial ischemia ... often termed diastolic heart failure Atrial fibrillation, other cardiac arrhythmias, or sudden cardiac death Heart failure can ... hypertrophy in athletes Congestive heart failure or heart failure with normal ejection fraction due to other causes Atrial ...
These thickenings will go on to fuse and remodel to eventually form the valves and septa of the mature adult heart. Endocardial ... Upon sectioning of the heart the atrioventricular endocardial cushions can be observed in the lumen of the atrial canal as two ... A problem in endocardial cushion development or remodeling is thought to be associated with atrioventricular septal defect. The ... As heart development continues this tube undergoes conformational changes and remodeling to eventually form the four-chambered ...
... , also called atrial natriuretic peptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene. ... Corin-mediated ANP production in the pregnant uterus promotes spiral artery remodeling and trophoblast invasion. CORIN ... Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt- ... Wu F, Yan W, Pan J, Morser J, Wu Q (May 2002). "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes". The ...
Working on sino atrial node cells by inhibiting T-type calcium channel activation, Efonidipine prolongs the late phase-4 ... By reducing synthesis and secretion of aldosterone, Efonidipine prevents hypertrophy and remodeling of cardiac myocytes. ... depolarization of the sino atrial node action potential and suppresses an elevated HR. The negative chronotropic effect of ...
Veno-occlusive remodelling[edit]. This theory proposes how high pulmonary venous pressures may lead to the capillary rupture ... pulmonary infection or atrial fibrillation, inflammation, longer distances, longer duration of exercise, hard surfaces, ... Other histopathologic findings include fibrosis, bronchial artery neovascularization, venous remodeling, bronchiolitis, ... with the venous remodeling leading to regional vascular congestion and hemorrhage, hemosiderin accumulation, fibrosis, and ...
One reason for this may be that once the heart has undergone atrial remodeling as in the case of chronic atrial fibrillation ... AF therefore have an increased chance of success with an ablation since their heart has not undergone atrial remodeling yet. ... For atrial fibrillation, several experienced teams of electrophysiologists in US heart centers claim they can achieve up to a ... Risks of catheter ablation for atrial fibrillation include, but are not limited to: stroke, esophageal injury, pulmonary vein ...
However, atrial natriuretic peptide is thought to be cardio-protective. Remodeling of the heart is evaluated by performing an ... Physiological remodeling is reversible while pathological remodeling is mostly irreversible. Remodeling of the ventricles under ... In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of ... This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling ...
"Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy". Nature. 484 (7393): 246-50. Bibcode: ... These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood ... ANP is secreted in response to: Stretching of the atrial wall, via Atrial volume receptors Increased Sympathetic stimulation of ... ANP is also called atrial natriuretic factor (ANF), atrial natriuretic hormone (ANH), cardionatrine, cardiodilatin (CDD), and ...
... reducing atrial contractility and potentially contributing to atrial fibrillation.[25] Structural changes in T-tubules can lead ... as some suggest that T-tubule remodelling might be reversed through the use of interval training.[5] ... T-tubules are found in both atrial and ventricular cardiac muscle cells (cardiomyocytes), in which they develop in the first ... in 2009 an extensive T-tubule network in atrial cardiac muscle cells was observed.[25] Ongoing research focusses on the ...
The difference between aortic and right atrial pressure accounts for blood flow in the circulation.[16] When the left ventricle ... and then undergo a significant remodelling[11] to form the final asymmetrical structure of the great arteries, with the 3rd ...
For atrial fibrillation, 120 to 200 joules for biphasic devices and 200 joules for monophasic devices For atrial flutter, 50 to ... They also decrease cardiac oxygen demand and can prevent cardiac remodeling. Not all beta blockers are the same; some are ... including atrial fibrillation and atrial flutter. It is also used in the emergent treatment of wide complex tachycardias, ... It has been shown to be effective in acute cardioversion of recent-onset atrial fibrillation and atrial flutter. Class IV drugs ...
Atrial stretch induced by increased atrial pressure may precipitate atrial fibrillation through some effect on atrial ... Thus, it is possible that the elevation of atrial pressure might cause electrical remodeling by the upregulation of atrial AT1 ... However, long-term rapid atrial pacing might be necessary to examine the time course of atrial electrical remodeling and the ... Therefore, we continued rapid atrial pacing for 3 hours, which was enough to evaluate acute atrial electrical remodeling. In ...
... and such a remodeling has also been called atrial tachycardia remodeling.1,2,42,43 Atrial tachycardia remodeling is suggested ... Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to ... Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial- tachycardia remodeling in dogs. ... Background-A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial electric remodeling associated ...
Left atrial (LA) enlargement is a common finding in hypertensive patients (pts), however little information is available on LA ... OBJECTIVES: Left atrial (LA) enlargement is a common finding in hypertensive patients (pts), however little information is ... hypertension showed a more marked increased of LA volumes compared to gestational hypertension due to a remodeling of atrial ...
... causes tachycardia-induced atrial electrical remodeling, contributing to the progressive nature of the arrhythmia. Ventricular ... dysfunction due to a rapid response to AF can cause structural remodeling, but whether ... OBJECTIVE: Atrial fibrillation (AF) causes tachycardia-induced atrial electrical remodeling, contributing to the progressive ... Atrial tissue from 1-week atrial-tachypaced dogs with ventricular rate control similarly showed upregulation of alpha SMA ...
... levels predict left atrial reverse remodeling after catheter ablation in patients with atrial fibrillation (AF) ... HealthDay News - Preprocedural serum atrial natriuretic peptide (ANP) levels predict left atrial reverse remodeling after ... "In this study, 47% of the patients exhibited left atrial reverse remodeling after RFCA for AF, with a concomitant improvement ... before RFCA and maintenance of sinus rhythm during follow-up were independent predictors of left atrial reverse remodeling ( ...
... cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial ... either of atrial or of ventricular origin, remains a major challenge. Sudden ... Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias. ... The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden ...
Measurement of left atrial (LA) volume by the biplane area-length method where A2Ch and A4Ch refer to the LA area in the two- ... Background Left atrial (LA) size is an adverse prognostic marker. Aortic stenosis results in increased filling pressures with ... progressive left atrial enlargement and dysfunction. Intervention for aortic stenosis results in LV reverse remodelling, ...
Atrial Fibrillation. Atrial Remodeling. Vascular Diseases. Cardiovascular Diseases. Arrhythmias, Cardiac. Heart Diseases. ... Structural Remodeling (left atrial volume, left. *ventricular mass, left ventricular diastolic function. Evaluated at ... Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and ... Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension, Permanent ...
Atrial natriuretic peptide (ANP) reduces pulmonary vascular resistance and attenuates hypoxia-induced pulmonary hypertension in ... Measurement: pulmonary hypertension, right ventricular hypertrophy, and pulmonary arterial and alveolar remodeling were ... to test the hypothesis that ANP modulates the pulmonary vascular and alveolar remodeling response to normobaric hypoxic stress ... resulting in pulmonary vascular remodeling characterized by hyperplasia of pulmonary arterial smooth muscle cells (PASMCs) and ...
Defining biological markers of atrial remodelling would help identify patients at high risk who would benefit most from ... Biomarkers of atrial fibrillation progression would be helpful for following patients that present with asymptomatic atrial ... Notably, the roles of such markers in the pathophysiology of atrial fibrillation must be determined. Some markers may indicate ... Although a number of markers have been reported as potential predictors of paroxysmal atrial fibrillation progression towards ...
Atrial fibrillation begets atrial fibrillation: autonomic mechanism for atrial electrical remodeling induced by short-term ... seem to play a more relevant role for atrial electrical remodeling during AF. Atrial electrical remodeling results mainly from ... Renal Sympathetic Denervation Provides Ventricular Rate Control But Does Not Prevent Atrial Electrical Remodeling During Atrial ... Renal Sympathetic Denervation Provides Ventricular Rate Control But Does Not Prevent Atrial Electrical Remodeling During Atrial ...
1999) Promotion of atrial fibrillation by heart failure in dogs Atrial remodeling of a different sort. Circulation, 100, 87-95 ... 1999) Promotion of atrial fibrillation by heart failure in dogs: Atrial remodeling of a different sort. Circulation, 100, 87-95 ... symptomatic atrial fibrillation and heart failure. Randomized studies and observational data suggest that atrial fibrillation ... TITLE: Atrial fibrillation ablation in patients with heart failure review. AUTHORS: Mohammad I. Amin, Laurence D. Sterns, ...
Whether increased MMP activity directly contributes to atrial remodeling and AF in the setting of HF remains unclear. The ... play a role in extracellular remodeling, and recent studies have demonstrated increased atrial MMP activity in HF. ... The SAVP-MMPi dogs had significantly smaller increases in atrial myocyte cross sectional area, collagen area fraction, and MMP- ... current study examined the effects of MMP inhibition on atrial structural remodeling and AF vulnerability during HF progression ...
Background The contribution of progressive left atrial (LA) enlargement to elevated pulmonary capillary wedge pressure (PCWP) ... Association of echocardiographic atrial size and atrial fibrosis in a sequential model of congestive heart failure and atrial ... Effects of quinapril on left atrial structural remodeling and arterial stiffness. Am J Cardiol. 2006;97(6):916-20.CrossRef ... Contribution of the left atrial remodeling to the elevated pulmonary capillary wedge pressure in patients with WHO Group II ...
Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation. 1999;100:87-95. ... Electrical remodeling of the human atrium: similar effects in patients with chronic atrial fibrillation and atrial flutter. J ... Reverse atrial electrical remodelling following atrial defibrillation as determined by signal-averaged ECG. Can J Cardiol. 2004 ... Relevance of Electrical Remodeling in Human Atrial FibrillationClinical Perspective. Results of the Asymptomatic Atrial ...
... worlds leading medical scientists to share in a highly interactive environment the most recent advances in the field of atrial ... ionic remodeling and atrial fibrosis. Atrial fibrosis itself adds back to this, and results in persistent atrial fibrillation. ... Impact of atrial remodeling on AF outcomes 2013-10-01 Marking the very first presentation of the 2015 AF Symposium, Prashanthan ... Left atrial pressure and pulmonary artery pressure increased, and left atrial size increased, although the animals were too big ...
Nattel S, Burstein B, Dobrev D. Atrial remodelling and atrial fibrillation: mechanisms and implications. Circ Arrhythmia ... ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes; Cardiovasc Res. 2007 Oct 26; [ ... Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circ ... ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res. 2008; 77: 35- ...
Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural remodeling which impairs ... Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation. Publication. ... atrial fibrillation, mitochondria, MCU, Ru360, SS31 Persistent URL. dx.doi.org/10.3390/cells8101202, hdl.handle.net/1765/122262 ... Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation. Cells, 8(10). ...
Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation: Data of the RACE II ( ... Is lenient rate control associated with more adverse cardiac remodeling than strict rate control in patients with atrial ... Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation: Data of the RACE II ( ... It is possible that adverse remodeling would have occurred in this group if the resting rate had been closer to 110 bpm, ...
... remodeling and fibrosis in paroxysmal atrial fibrillation (AF) using speckle tracking echocardiography (STE) based on the ... This study aimed to evaluate left atrial (LA) ... Assessment of left atrial remodeling in paroxysmal atrial ... Hong J, Gu X, An P, Luo T, Lv Q, Kang J, He Y, Hu R, Liu X, Ma C (2013) Left atrial functional remodeling in lone atrial ... Li D, Fareh S, Leung TK, Nattel S (1999) Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a ...
Atrial Heterogeneous Autonomic Neural Remodeling in Rabbits with Experimental Atrial Fibrillation and the Effect of ... inducibility of atrial fibrillation (AF), and changes of atrial autonomic neural remodeling (ANR) by rosuvastatin intervention ... Persistent rapid atrial pacing can lead to heterogeneous ANR in different parts of the rabbit atrium and may cause AF, which ... The sympathetic and parasympathetic nerves of left atrium, right atrium, and atrial septum labeled with tyrosine hydroxylase ( ...
... induced atrial structural and electrical remodeling and contributes to AF perpetuation. BACKGROUND Galectin-3 (Gal-3) mediates ... The Gal-3 inhibitor GM-CT-01 (GMCT) reduced both Gal-3 and TGF-β1-induced sheep atrial fibroblast migration and proliferation ... and also mitigated atrial dilatation, myocyte hypertrophy, fibrosis, and the expected increase in dominant frequency of ... intracardiac serum Gal-3 levels were greater in persistent than paroxysmal AF and independently predicted atrial ...
RAA = right atrial appendage; RAFW = right atrial free wall; LAA = left atrial appendage; LAFW = left atrial free wall. ... of the right atrial appendage and intra-atrial conduction time (CT) from the right atrial appendage to the lower right atrial ... 1999) Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation 100:87-95. ... 2002) Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure. Cardiovasc Res ...
LA electrical and structural remodeling leads to rhythm disorders such as atrial ectopic beats and atrial fibrillation (AF) (18 ... 2013) Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing ... Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial ... left atrial volume index. LVMI. left ventricular mass index. PAC. premature atrial contractions. proBNP. pro-brain natriuretic ...
Electrical Remodeling of the Human Atrium: Similar Effects in Patients With Chronic Atrial Fibrillation and Atrial Flutter ... Electrical Remodeling of the Human Atrium: Similar Effects in Patients With Chronic Atrial Fibrillation and Atrial Flutter ... Electrical Remodeling of the Human Atrium: Similar Effects in Patients With Chronic Atrial Fibrillation and Atrial Flutter ... and atrial flutter in patients lead to electrical remodeling of the human atrial myocardium, manifested by an abnormal relation ...
  • Transverse t-tubules are a common feature in large mammalian atrial myocytes including human. (kompetenznetz-vorhofflimmern.de)
  • Objective: To determine the mechanisms underlying electrophysiological effects of palmitic (PA), stearic (SA) and oleic (OA) FFAs on sheep atrial myocytes. (umn.edu)
  • Methods: We used electrophysiological techniques, numerical simulations, biochemistry and optical imaging to examine the effects of acutely (≤ 15 min), short-term (4-6 hour) or 24-hour application of individual FFAs (10 μM) on isolated ovine left atrial myocytes (LAMs). (umn.edu)
  • Results: Acute and short-term incubation in FFAs resulted in no differences in passive or active properties of isolated left atrial myocytes (LAMs). (umn.edu)
  • Conclusions: SA disrupts t-tubular architecture and remodels properties of membrane ionic currents in sheep atrial myocytes, with potential implications in arrhythmogenesis. (umn.edu)
  • The perpetuation of AF and continuous electrophysiological disturbance (electrical remodelling) in atrial myocytes ultimately cause cell apoptosis, and then fibrotic tissue replaces the dead atrial myocytes. (bmj.com)
  • Action potential waveforms and gating of less sialylated voltage-gated Na + channels were altered consistently in ST8sia2 (−/−) atrial myocytes. (pnas.org)
  • In this issue of the JCI , Greiser and coworkers discovered that atrial remodeling in response to sustained tachycardia silences Ca 2+ signaling in isolated rabbit and human atrial myocytes. (jci.org)
  • Besides, reduced expression of V1 mysoin and L-type calcium channels on cardiac myocytes are also thought to cause cardiac remodelling. (wikipedia.org)
  • The AF duration, atrial effective refractory period (AERP) at four sites in the RA, and intra-atrial conduction time (CT) from the RA appendage to the other three sites were measured every week. (onlinejacc.org)
  • CHF causes atrial connexin changes, but these are not essential for CHF-related conduction disturbances and AF promotion, which are rather related primarily to fibrotic interruption of muscle bundle continuity. (ahajournals.org)
  • We therefore exploited CHF reversal to assess the reversibility of atrial connexin alterations and evaluate their contribution to CHF-related conduction disturbances and AF maintenance. (ahajournals.org)
  • Nowadays echocardiography is the mainstream technique for detecting LASRM which may cause left atrial (LA) volume expansion and atrial conduction slowing and heterogeneity. (bmj.com)
  • Intra-atrial conduction time (CT) was defined as the interval from the stimulus at the high right atrium to atrial deflection at the distal portion of the coronary sinus. (cdc.gov)
  • Hypoxic stress upsets the balance in the normal relationships between mitogenic and growth inhibiting pathways in lung, resulting in pulmonary vascular remodeling characterized by hyperplasia of pulmonary arterial smooth muscle cells (PASMCs) and fibroblasts and enhanced deposition of extracellular matrix. (ovid.com)
  • BACKGROUND Galectin-3 (Gal-3) mediates extracellular matrix remodeling in heart failure, but its role in AF progression remains unexplored. (semanticscholar.org)
  • The interplay between cardiac matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of MMPs (TIMPs), is thought to be critical in atrial extracellular matrix (ECM) metabolism. (elsevier.com)
  • However, LV remodeling due to structural and functional changes in the extracellular matrix (ECM) often progresses even following successful revascularization and is the most common reason for heart failure after myocardial infarction (3,4) . (onlinejacc.org)
  • Myocardial remodeling is a complex and heterogeneous process involving cardiac myocyte alterations, activation of fibroblasts, and transdifferentiation to myofibroblasts (MyoFb) as well as a dynamic functional and structural reorganization of the cardiac extracellular matrix (cECM) [ 2 , 4 - 6 ]. (hindawi.com)
  • The objective of this study was to assess atrial electrophysiological and structural characteristics in BrS and their relationships with gene mutations. (cdc.gov)
  • Atrial natriuretic peptide (ANP) reduces pulmonary vascular resistance and attenuates hypoxia-induced pulmonary hypertension in vivo and PASMC proliferation and collagen synthesis in vitro. (ovid.com)
  • The current study utilized an ANP null mouse model (Nppa−/−) to test the hypothesis that ANP modulates the pulmonary vascular and alveolar remodeling response to normobaric hypoxic stress. (ovid.com)
  • The contribution of progressive left atrial (LA) enlargement to elevated pulmonary capillary wedge pressure (PCWP) in patients with WHO Group II pulmonary hypertension (PH) has not been well studied. (springer.com)
  • PURPOSE: Circumferential pulmonary (PV) vein isolation (CPVI) is the most important treatment strategy for atrial fibrillation (AF). (yonsei.ac.kr)
  • 11 With respect to repetitive activity in small atrial areas, however, Mandapati et al 12 demonstrated in healthy sheep hearts that repetitive reentry in the posterior left atrium near or at pulmonary vein ostia can produce microreentrant sources for AF. (ahajournals.org)
  • She is currently working on studies on cardiac remodeling pulmonary hypertension with the goal of understanding the influence of inflammation and finding early biomarkers of remodeling. (stanford.edu)
  • PhD, Universite Paris Sud - Paris Saclay (France), Right Heart Remodeling in Pulmonary Hypertension: from deep phenotyping to proteomics profiling. (stanford.edu)
  • Pathologic pressure mismatches between the pulmonary and systemic circulation guide compensatory remodeling of the left and right ventricles. (wikipedia.org)
  • 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. (medscape.com)
  • ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation). (medscape.com)
  • In 2014, the American Heart Association/American College of Cardiology/Heart Rhythm Society (AHA/ACC/HRS) released updated guidelines for the management of patients with atrial fibrillation (AF). (medscape.com)
  • The sympathetic and parasympathetic nerves of left atrium, right atrium, and atrial septum labeled with tyrosine hydroxylase (TH) and choline acetyl transferase (ChAT) were detected by immunohistochemistry and Western blot. (ovid.com)
  • Segments included 4 regions around each PV, and the LA posterior wall and inter-atrial septum. (biomedcentral.com)
  • Li J, Yang Y, Ng CY, Zhang Z, Liu T, Li G (2016) Association of Plasma Transforming Growth Factor-β1 Levels and the Risk of Atrial Fibrillation: A Meta-Analysis. (plos.org)
  • Methods and Results- The miRNA transcriptome was analyzed by microarray and verified by real-time reverse-transcription polymerase chain reaction with left atrial samples from dogs with AF established by right atrial tachypacing for 8 weeks and from human atrial samples from AF patients with rheumatic heart disease. (ahajournals.org)
  • METHODS: Cultured canine atrial fibroblasts were treated with medium from rapidly-paced atrial cardiomyocytes, non-paced cardiomyocytes and cardiomyocyte-pacing medium only, and analyzed by [(3)H]thymidine incorporation, Western blot and real-time RT-PCR. (biomedsearch.com)
  • A pacing lead introduced into the femoral vein was placed in the right atrial appendage to measure the AERP. (ahajournals.org)
  • To minimize confounding effects caused by electrode polarization, all refractory period measurements were made with the pacing lead, which was not used for high-frequency pacing and was positively affixed to the right atrial appendage. (ahajournals.org)