A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
Cell surface proteins that bind ATRIAL NATRIURETIC FACTOR with high affinity and trigger intracellular changes influencing the behavior of cells. They contain intrinsic guanylyl cyclase activity.
Endogenous or exogenous chemicals that regulate the WATER-ELECTROLYTE BALANCE in the body. They consist of peptides and non-peptide compounds.
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
Sodium excretion by URINATION.
A PEPTIDE of 22 amino acids, derived mainly from cells of VASCULAR ENDOTHELIUM. It is also found in the BRAIN, major endocrine glands, and other tissues. It shares structural homology with ATRIAL NATRIURETIC FACTOR. It has vasorelaxant activity thus is important in the regulation of vascular tone and blood flow. Several high molecular weight forms containing the 22 amino acids have been identified.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
The chambers of the heart, to which the BLOOD returns from the circulation.
Peptides that regulate the WATER-ELECTROLYTE BALANCE in the body, also known as natriuretic peptide hormones. Several have been sequenced (ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; C-TYPE NATRIURETIC PEPTIDE).
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
The hemodynamic and electrophysiological action of the HEART ATRIA.
The hollow, muscular organ that maintains the circulation of the blood.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
A ubiquitous sodium salt that is commonly used to season food.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
The circulation of the BLOOD through the vessels of the KIDNEY.
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Sense of awareness of self and of the environment.
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.
General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
Agents that promote the excretion of urine through their effects on kidney function.
Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.
Refers to animals in the period of time just after birth.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The main trunk of the systemic arteries.
The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.
Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate.
Elements of limited time intervals, contributing to particular results or situations.
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
Hypertension due to RENAL ARTERY OBSTRUCTION or compression.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
The process by which fetal Rh+ erythrocytes enter the circulation of an Rh- mother, causing her to produce IMMUNOGLOBULIN G antibodies, which can cross the placenta and destroy the erythrocytes of Rh+ fetuses. Rh isoimmunization can also be caused by BLOOD TRANSFUSION with mismatched blood.
A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The nonstriated involuntary muscle tissue of blood vessels.
Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
The active metabolite of ENALAPRIL and a potent intravenously administered angiotensin-converting enzyme inhibitor. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion.
A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
The quantity of volume or surface area of CELLS.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
Contractile activity of the MYOCARDIUM.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.
Discharge of URINE, liquid waste processed by the KIDNEY, from the body.
The measurement of an organ in volume, mass, or heaviness.
The functional units of the kidney, consisting of the glomerulus and the attached tubule.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
Tapping fluid from the subarachnoid space in the lumbar region, usually between the third and fourth lumbar vertebrae.
The rate dynamics in chemical or physical systems.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.
Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.

A low-affinity serum response element allows other transcription factors to activate inducible gene expression in cardiac myocytes. (1/2854)

Hypertrophic growth of cardiac muscle cells is induced by a variety of physiological and pathological stimuli and is associated with a number of changes, including activation of genes such as atrial natriuretic factor. We found that two serum response element (SRE)-like DNA elements, one of which does not meet the consensus sequence and binds serum response factor (SRF) with low affinity, regulate the activity of this promoter. Surprisingly, the ability to induce the promoter by two different physiologic stimuli, as well as various activated transcription factors, including SRF-VP16, was primarily dependent upon the nonconsensus rather than the consensus SRE. This SRE controls the induction of gene expression via an unusual mechanism in that it is required to allow some, but not all, active transcription factors at unrelated sites on the promoter to stimulate gene expression. Thus, in addition to regulation of SRF activity by growth stimuli, regulation of a low-affinity SRE element controls inducible gene expression by modulating the ability of other transcription factors to stimulate the transcription machinery.  (+info)

Low calorie diet enhances renal, hemodynamic, and humoral effects of exogenous atrial natriuretic peptide in obese hypertensives. (2/2854)

The expression of the natriuretic peptide clearance receptor is abundant in human and rat adipose tissue, where it is specifically inhibited by fasting. In obese hypertensives, plasma atrial natriuretic peptide (ANP) levels were found to be lower than in obese normotensives. Therefore, the increased adipose mass might influence ANP levels and/or its biological activity. The aim of the present study was to evaluate whether the humoral, hemodynamic, and renal effects of exogenous ANP in obese hypertensives might be enhanced by a very low calorie diet. Eight obese hypertensives received a bolus injection of ANP (0.6 mg/kg) after 2 weeks of a normal calorie/normal sodium diet, and blood pressure (BP), heart rate, ANP, cGMP, plasma renin activity, and aldosterone were evaluated for 2 hours before and after the injection. Diuresis and natriuresis were measured every 30 minutes. The patients then started a low calorie/normal sodium diet (510 kcal/150 mmol/d) for 4 days, and then the ANP injection protocol was repeated. The low calorie diet induced a slight weight loss (from 90.6+/-1.1 to 87. 7+/-1.2 kg; P<0.01), which was accompanied by increase of cGMP excretion (from 146.0+/-10.1 to 154.5+/-9.5 nmol/24 h; P<0.05) together with a reduction of BP (P<0.01 versus basal levels). ANP injection after diet was followed by an increase of ANP levels similar to that observed before diet, but plasma cGMP, diuresis, and natriuresis increased significantly only after diet. Similarly, the decrease of BP after ANP administration was significantly higher after diet (change in mean arterial pressure, -6.4+/-0.7 versus -4. 0+/-0.6 mm Hg; P<0.05) as well as that of aldosterone (P<0.01). These data show that a low calorie diet enhances the humoral, renal, and hemodynamic effects of ANP in obese hypertensives and confirm the importance of caloric intake in modulating the biological activity of ANP, suggesting that the natriuretic peptide system can play a role in the acute changes of natriuresis and diuresis associated with caloric restriction.  (+info)

Peri-operative changes in echocardiographic measurements and plasma atrial and brain natriuretic peptide concentrations in 3 dogs with patent ductus arteriosus. (3/2854)

Peri-operative changes in echocardiographic measurements and plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were investigated for 1 month in 3 dogs with patent ductus arteriosus (PDA). Post-operative left ventricular end-diastolic dimention and fractional shortening decreased in all cases. Pre-operatively increased plasma ANP concentrations reduced dramatically after the operation. Peri-operative changes in plasma BNP levels had slightly S-shaped curves in all cases. These observations suggest that post-operative responsiveness of ANP and cardiac function are rapid in comparison with cardiac morphological changes, and BNP has a different pathophysiological significance from ANP in dogs with PDA.  (+info)

Sperm chemotaxis. (4/2854)

Communication between spermatozoa and egg before contact by chemotaxis appears to be prevalent throughout the animal kingdom. In non-mammalian species, sperm chemotaxis to factors secreted from the egg is well documented. In mammals, sperm chemotaxis to follicular factors in vitro has been established in humans and mice. The attractants of female origin in non-mammalian species are heat-stable peptides or proteins of various sizes, or other small molecules, depending on the species. Species specificity of the attractants in non-mammalian species may vary from high species specificity, through specificity to families with no specificity within a family, to absence of specificity. The mammalian sperm attractants have not been identified but they appear to be heat-stable peptides. The claim that progesterone is the attractant for human spermatozoa has failed to be substantiated, neither have claims for other mammalian sperm attractants been verified. The molecular mechanism of sperm chemotaxis is not known. Models involving modulation of the intracellular Ca2+ concentration have been proposed for both mammalian and non-mammalian sperm chemotaxis. The physiological role of sperm chemotaxis in non-mammalian species appears to differ from that in mammals. In non-mammalian species, sperm chemotaxis strives to bring as many spermatozoa as possible to the egg. However, in mammals, the role appears to be recruitment of a selective population of capacitated ('ripe') spermatozoa to fertilize the egg.  (+info)

Physiological variability of fluid-regulation hormones in young women. (5/2854)

We tested the physiological reliability of plasma renin activity (PRA) and plasma concentrations of arginine vasopressin (P[AVP]), aldosterone (P[ALD]), and atrial natriuretic peptide (P[ANP]) in the early follicular phase and midluteal phases over the course of two menstrual cycles (n = 9 women, ages 25 +/- 1 yr). The reliability (Cronbach's alpha >/=0.80) of these hormones within a given phase of the cycle was tested 1) at rest, 2) after 2.5 h of dehydrating exercise, and 3) during a rehydration period. The mean hormone concentrations were similar within both the early follicular and midluteal phase tests; and the mean concentrations of P[ALD] and PRA for the three test conditions were significantly greater during the midluteal compared with the early follicular phase. Although Cronbach's alpha for resting and recovery P[ANP] were high (0.80 and 0.87, respectively), the resting and rehydration values for P[AVP], P[ALD], and PRA were variable between trials for the follicular (alpha from 0.49 to 0.55) and the luteal phase (alpha from 0.25 to 0. 66). Physiological reliability was better after dehydration for P[AVP] and PRA but remained low for P[ALD]. Although resting and recovery P[AVP], P[ALD], and PRA were not consistent within a given menstrual phase, the differences in the concentrations of these hormones between the different menstrual phases far exceeded the variability within the phases, indicating that the low within-phase reliability does not prevent the detection of menstrual phase-related differences in these hormonal variables.  (+info)

Cardiovascular, endocrine, and renal effects of urodilatin in normal humans. (6/2854)

Effects of urodilatin (5, 10, 20, and 40 ng. kg-1. min-1) infused over 2 h on separate study days were studied in eight normal subjects with use of a randomized, double-blind protocol. All doses decreased renal plasma flow (hippurate clearance, 13-37%) and increased fractional Li+ clearance (7-22%) and urinary Na+ excretion (by 30, 76, 136, and 99% at 5, 10, 20, and 40 ng. kg-1. min-1, respectively). Glomerular filtration rate did not increase significantly with any dose. The two lowest doses decreased cardiac output (7 and 16%) and stroke volume (10 and 20%) without changing mean arterial blood pressure and heart rate. The two highest doses elicited larger decreases in stroke volume (17 and 21%) but also decreased blood pressure (6 and 14%) and increased heart rate (15 and 38%), such that cardiac output remained unchanged. Hematocrit and plasma protein concentration increased with the three highest doses. The renin-angiotensin-aldosterone system was inhibited by the three lowest doses but activated by the hypotensive dose of 40 ng. kg-1. min-1. Plasma vasopressin increased by factors of up to 5 during infusion of the three highest doses. Atrial natriuretic peptide immunoreactivity (including urodilatin) and plasma cGMP increased dose dependently. The urinary excretion rate of albumin was elevated up to 15-fold (37 +/- 17 micrograms/min). Use of a newly developed assay revealed that baseline urinary urodilatin excretion rate was low (<10 pg/min) and that fractional excretion of urodilatin remained below 0.1%. The results indicate that even moderately natriuretic doses of urodilatin exert protracted effects on systemic hemodynamic, endocrine, and renal functions, including decreases in cardiac output and renal blood flow, without changes in arterial pressure or glomerular filtration rate, and that filtered urodilatin is almost completely removed by the renal tubules.  (+info)

Second messenger production in avian medullary nephron segments in response to peptide hormones. (7/2854)

We examined the sites of peptide hormone activation within medullary nephron segments of the house sparrow (Passer domesticus) kidney by measuring rates of hormone-induced generation of cyclic nucleotide second messenger. Thin descending limbs, thick ascending limbs, and collecting ducts had baseline activity of adenylyl cyclase that resulted in cAMP accumulation of 207 +/- 56, 147 +/- 31, and 151 +/- 41 fmol. mm-1. 30 min-1, respectively. In all segments, this activity increased 10- to 20-fold in response to forskolin. Activity of adenylyl cyclase in the thin descending limb was stimulated approximately twofold by parathyroid hormone (PTH) but not by any of the other hormones tested [arginine vasotocin (AVT), glucagon, atrial natriuretic peptide (ANP), or isoproterenol, each at 10(-6) M]. Thick ascending limb was stimulated two- to threefold by both AVT and PTH; however, glucagon and isoproterenol had no effect, and ANP stimulated neither cAMP nor cGMP accumulation. Adenylyl cyclase activity in the collecting duct was stimulated fourfold by AVT but not by the other hormones; likewise, ANP did not stimulate cGMP accumulation in this segment. These data support a tubular action of AVT and PTH in the avian renal medulla.  (+info)

cGMP-dependent and -independent inhibition of a K+ conductance by natriuretic peptides: molecular and functional studies in human proximal tubule cells. (8/2854)

In immortalized human kidney epithelial (IHKE-1) cells derived from proximal tubules, two natriuretic peptide receptors (NPR) were identified. In addition to NPR-A, which is bound by atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and urodilatin (URO), a novel form of NPR-B that might be bound by C-type natriuretic peptide (CNP) was identified using PCR. This novel splice variant of NPR-B (NPR-Bi) was also found in human kidney. Whereas ANP, BNP, and URO increased intracellular cGMP levels in IHKE-1 cells in a concentration-dependent manner, CNP had no effect on cGMP levels. To determine the physiologic responses to these agonists in IHKE-1 cells, the membrane voltage (Vm) was monitored using the slow whole-cell patch-clamp technique. ANP (10 nM), BNP (10 nM), and URO (16 nM) depolarized these cells by 3 to 4 mV (n = 47, 7, and 16, respectively), an effect that could be mimicked by 0.1 mM 8-Br-cGMP (n = 15). The effects of ANP and 8-Br-cGMP were not additive (n = 4). CNP (10 nM) also depolarized these cells, by 3+/-1 mV (n = 28), despite the absence of an increase in cellular cGMP levels, indicating a cGMP-independent mechanism. In the presence of CNP, 8-Br-cGMP further depolarized Vm significantly, by 1.6+/-0.3 mV (n = 5). The depolarizations by ANP were completely abolished in the presence of Ba2+ (1 mM, n = 4) and thus can be related to inhibition of a K+ conductance in the luminal membrane of IHKE-1 cells. The depolarizations attributable to CNP were completely blocked when genistein (10 microM, n = 6), an inhibitor of tyrosine kinases, was present. These findings indicate that natriuretic peptides regulate electrogenic transport processes via cGMP-dependent and -independent pathways that influence the Vm of IHKE-1 cells.  (+info)

1. The effect of a α-human atrial natriuretic peptide (1-28) (ANP) on human vasculature was investigated in vivo and in vitro. Possible involvement of vascular dopamine receptors and the renin-angiotensin system in the response to ANP was also studied in vivo.. 2. Forearm blood blow was measured by venous occlusion plethysmography. Isolated human blood vessels were studied using conventional organ bath techniques.. 3. ANP (0.1-1 μg/min, intra-arterially) produced a dose-dependent increase in forearm blood flow, corresponding to a 163% increase in net forearm blood flow in the study arm. This action of ANP was not antagonized by (R)-sulpiride (100 μg/min, intra-arterially), a selective vascular dopamine receptor antagonist, or 50 mg of oral captopril, an inhibitor of angiotensin-converting enzyme.. 4. ANP (1 nmol/l-1 μmol/l) produced concentration-dependent relaxation of isolated human arteries, including brachial artery, but was without effect on isolated human saphenous vein.. 5. ANP ...
TY - GEN. T1 - Acute hyperglycaemia causes elevation of plasma atrial natriuretic peptide concentrations in type 1 diabetes subjects. AU - McKenna, K. AU - Smith, D. AU - Tormey, William. AU - Thompson, CJ. PY - 1999. Y1 - 1999. M3 - Conference contribution. VL - 48. SP - A139-A139. BT - Unknown Host Publication. PB - John Wiley & Sons, Inc.. T2 - DIABETES. Y2 - 1 January 1999. ER - ...
The administration of exogenous atrial natriuretic peptide (ANP) resulted in numerous physiological responses, including a rapid natriuresis and diuresis as well as a reduction in arterial blood pressure. In order to provide a continuous supply of ANP, we used gene transfer approach to investigate the role of ANP in hypertensive rats and in normotensive animals with chronic heart failure. The human ANP gene placed under the control of RSV or CMV promoter with a 4F2 enhancer was incorporated into replication-deficient adenovirus. Expression of human ANP in cell culture or in rats was identified by RT-PCR Southern blot analysis and/or a radioimmunassay for human ANP. The results showed that a single injection of the ANP gene results in: 1) prolonged reduction of blood pressure in spontaneously hypertensive rats (SHR) and Dahl- salt sensitive (DSS) rats on a high salt diet, 2) increases in renal blood flow, glomerular filtration rate, sodium output, urine excretion and urinary cGMP levels, ...
alpha-Human atrial natriuretic peptide, a 28-amino-acid-residue peptide, was rapidly hydrolysed by pig kidney microvillar membranes in vitro, with a t1/2 of 8 min, comparable with the rate observed with angiotensins II and III. The products of hydrolysis were analysed by h.p.l.c., the pattern obtained with membranes being similar to that with purified endopeptidase-24.11 (EC No hydrolysis by peptidyl dipeptidase A (angiotensin I converting enzyme, EC was observed. The contribution of the various microvillar membrane peptidases was assessed by including specific inhibitors. Phosphoramidon, an inhibitor of endopeptidase-24.11, caused 80-100% suppression of the products. Captopril and amastatin (inhibitors of peptidyl dipeptidase A and aminopeptidases respectively) had no significant effect. Hydrolysis at an undefined site within the disulphide-linked ring occurred rapidly, followed by hydrolysis at other sites, including the Ser25--Phe26 bond. ...
Elevated plasma natriuretic peptide levels after AMI (acute myocardial infarction) are associated with adverse outcome. The aim of the present study was to examine the relationship of plasma N-ANP (N-terminal pro-atrial natriuretic peptide) and N-BNP (N-terminal pro-B-type natriuretic peptide) with mortality and heart failure following AMI. We studied 403 patients with AMI. Blood was sampled for measurement of N-ANP and N-BNP on a single occasion between 72 and 96 h after symptom onset. Natriuretic peptide levels were related to all-cause mortality and heart failure episodes. During follow up (median, 462 days; range 5-764), 43 (10.7%), 25 (6.2%) and 49 (12.2%) patients suffered death, heart failure hospitalization and outpatient heart failure respectively. Only N-BNP (P,0.0005), N-ANP (P=0.005) and previous AMI (P=0.016) were independently predictive of death. N-BNP, but not N-ANP, predicted 30-day mortality. N-ANP, but not N-BNP, predicted mortality after 30 days. N-BNP was the better ...
TY - JOUR. T1 - Atrial natriuretic polypeptide (ANP) in human ventricle increased gene expression of ANP in dilated cardiomyopathy. AU - Saito, Yoshihiko. AU - Nakao, Kazuwa. AU - Arai, Hiroshi. AU - Sugawara, Akira. AU - Morii, Narito. AU - Yamada, Takayuki. AU - Itoh, Hiroshi. AU - Shiono, Shozo. AU - Mukoyama, Masashi. AU - Obata, Kenji. AU - Yasue, Hirofumi. AU - Ohkubo, Hiroaki. AU - Nakanishi, Shigetada. AU - Imura, Hiroo. PY - 1987/10/14. Y1 - 1987/10/14. N2 - Tissue levels of atrial natriuretic polypeptide (ANP) messenger RNA (ANPmRNA) and ANP in the human atrium and ventricle were measured simultaneously by the blot hybridization technique and the specific radioimmunoassay for ANP. Hearts were obtained from two patients without cardiac complications and from a patient with dilated cardiomyopathy (DCM) at autopsy. Total RNA extracted from ventricles contained a hydridizing RNA band of the same size as atrial ANPmRNA in both control and DCM hearts. The ANPmRNA level in the control ...
Previous studies have shown that atrial natriuretic factor, a powerful vasorelaxant of precontracted vessels, inhibits the secretion of aldosterone stimulated by angiotensin II, adrenocorticotropic hormone, and potassium. We now report the presence of specific binding sites for atrial natriuretic factor in rat blood vessels (mesenteric and renal arteries) and adrenal capsules. Radioiodinated synthetic atrial natriuretic factor bound to a single class of high-affinity (KD = 0.1 nM) low-capacity receptors in a particulate fraction from blood vessels and adrenals. Unrelated peptides did not displace atrial natriuretic factor. Fragments of atrial natriuretic factor displaced the labeled ligand with decreasing potency after cleavage at the N-terminal. The cleavage of the C-terminal tyrosine did not decrease the potency of atrial natriuretic factor, but further cleavage at the C-terminal dramatically reduced the affinity of the resulting peptides. The potency of the atrial natriuretic factor fragments ...
1. The effects of the infusion of a low dose (2 pmol min−1 kg−1 for 3 h) of human atrial natriuretic peptide (hANP) were studied in seven healthy volunteers undergoing a water diuresis. Lithium clearance was used to monitor proximal tubular function.. 2. hANP increased urine flow rate, sodium, calcium and magnesium excretion without significant changes in potassium and phosphate excretion, heart rate or blood pressure.. 3. hANP caused a small change in fractional lithium clearance, and larger changes in distal nephron handling of sodium and water.. 4. Plasma renin activity tended to decrease during the infusion of hANP, while plasma aldosterone concentration decreased during and increased after stopping the infusion of hANP.. 5. The data suggest that hANP inhibits the reabsorption of sodium and water by an action on distal segments of the nephron and perhaps the proximal tubule. Inhibition of renin and aldosterone secretion may contribute to the natriuresis. ...
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species ...
Plasma atrial natriuretic peptide in essential hypertension: effects of changes in dietary sodium. Sagnella, Giuseppe A.; Markandu, Nirmala D.; Buckley, Martin G.; Singer, Donald R.J.; Sugden, A. Louise; Shore, Angela C.; MacGregor, Graham A. // British Medical Journal (Clinical Research Edition);8/15/1987, Vol. 295 Issue 6595, p417 Examines the plasma atrial natriuretic peptide in essential hypertension. Effects of changes in dietary intake on plasma atrial peptides; Occurrence of change in plasma concentration of atrial peptide values during the transfer from normal to high sodium diet; Correlation between the fall in... ...
1. To study the anti-hypertensive effects of atrial natriuretic peptide (ANP), eight patients with mild to moderate essential hypertension, on no treatment, were infused with α-human ANP (102-126) (37 pmol min−1 kg−1) or placebo for 60 min and observed for a further 4 h on the fifth day of low and high sodium diets in a randomized, cross-over study.. 2. Plasma ANP levels increased over 30-fold into the high pathophysiological range during ANP infusion, but had returned to control values by 60 min after the end of infusion. With ANP infusion, there was a large decrease in supine blood pressure which was similar on both the low and high sodium intakes and was maximal 20-40 min after completion of the infusion. These reductions in blood pressure were sustained for a further 4 h after the end of ANP infusion and for 3 h after plasma ANP levels had returned to control values.. 3. Maximal urinary sodium excretion increased 10-fold on the low sodium diet (negative sodium balance 20 mmol) and ...
[Effects of female sex hormones on atrial natriuretic factor gene expression in rats].: To clarify the effects of female sex hormones on ANF gene expression, em
We investigated the hemodynamic effect of synthetic atrial natriuretic factor Auriculin A (ANF) and its influence on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits anesthetized with alpha-chloralose and urethane. The neural mechanisms underlying these effects were also studied. In the intact animal, a 45-minute constant infusion of ANF (2 micrograms/kg prime, 0.2 microgram/kg/min) significantly reduced mean blood pressure and increased mean perfusion pressure, while heart rate did not change. Comparable data were obtained with lower (0.5 microgram/kg + 0.05 microgram/kg/min; 1 microgram/kg + 0.1 microgram/kg/min) or higher (4 micrograms/kg + 0.4 microgram/kg/min; 8 micrograms/kg + 0.8 microgram/kg/min) doses of ANF. In addition, ANF enhanced bradycardic reflex responses to phenylephrine i.v. bolus administration, while it did not change baroreflex-mediated responses to nitroglycerin i.v. bolus ...
Definition of atrial natriuretic factor in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is atrial natriuretic factor? Meaning of atrial natriuretic factor as a finance term. What does atrial natriuretic factor mean in finance?
To explore whether pathophysiological plasma levels of atrial natriuretic peptide (ANP) actually involve sodium excretion in spontaneously hypertensive rats (SHR), we examined the in vivo and ex vivo effects of ANP and an endopeptidase inhibitor, thiorphan, on urinary sodium excretion and the elimination rate of ANP. We found the following: 1) The basal plasma ANP level was higher in 16-week-old SHR than in Wistar-Kyoto (WKY) rats (109 +/- 10 [SEM] versus 63 +/- 4 pg/ml, p less than 0.001). Thiorphan (30 mg/kg i.v.) significantly increased plasma ANP by 60% in both SHR and WKY rats. However, increases in urinary sodium excretion (+290% versus +130%, p less than 0.05) and cyclic GMP (+160% versus +60%, p less than 0.05) were greater in SHR than in WKY rats. Urinary excretion of ANP was markedly increased by thiorphan, and its increase was greater in SHR than in WKY rats. 2) The thiorphan-induced natriuresis was substantially attenuated by antiserum for ANP but not by a bradykinin receptor ...
Renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury and a frequent occurrence in critically ill patients. Renal IRI releases proinflammatory cytokines within the kidney that induce crosstalk between the kidney and other organ systems. Atrial natriuretic peptide (ANP) has anti-inflammatory as well as natriuretic effects and serves important functions as a regulator of blood pressure, fluid homeostasis, and inflammation. The objective of the present study was to elucidate whether ANP post-treatment attenuates kidney-lung-heart crosstalk in a rat model of renal IRI. In experiment I, a rat model of unilateral renal IRI with mechanical ventilation was prepared by clamping the left renal pedicle for 30 min. Five minutes after clamping, saline or ANP (0.2 μg/kg/min) was infused. The hemodynamics, arterial blood gases, and plasma concentrations of lactate and potassium were measured at baseline and at 1, 2, and 3 h after declamping. The mRNA expression and localization of tumor
METHODS AND RESULTS Twenty patients with acute right ventricular infarction were examined who underwent reperfusion therapy on admission. These patients had proximal occlusion of the dominant right coronary artery involving the right atrial branches: 9 patients with successful reperfusion (SRP group) and the remaining 11 patients with unsuccessful reperfusion (URP group). Within 24 hours after the onset of infarction, a volume loading test was performed after reperfusion therapy with measurements for plasma ANP levels and hemodynamics. Before the volume loading test, the plasma ANP level and mean right atrial pressure were similar between these two groups. However, in the URP group, percent increase in ANP in response to volume loading was strikingly smaller (URP, 45 +/- 18% versus SRP, 133 +/- 25%; P , .01) despite similar percent increase in mean right atrial pressure (URP, 100 +/- 46% versus SRP, 86 +/- 23%). The peak ANP level occurred significantly later in the URP group (69 +/- 16 hours) ...
In response to a high salt intake, salt-sensitive hypertensive individuals retain more sodium and manifest a rise in blood pressure greater than that in salt-resistant individuals. In this study, we tested whether salt sensitivity might be related at least in part to reduced secretion of atrial natriuretic peptide (ANP) or to abnormal nitric oxide production. We measured plasma ANP and NO2+NO3 in 7 normotensive individuals and 13 salt- sensitive and 14 salt-resistant blacks with essential hypertension under conditions of low (10 mEq/d) and high (250 mEq/d) salt intake. To evaluate possible racial differences in ANP secretion, we also measured plasma ANP in 6 salt-sensitive and 8 salt-resistant hypertensive whites during low and high salt intakes. Under low salt conditions, plasma ANP levels were not different in normotensive control subjects and salt-sensitive and salt-resistant hypertensive blacks. During high salt intake, plasma ANP levels did not change in control subjects and salt-resistant ...
A 75-year-old Japanese man was hospitalized for hypokalemia. Levels of plasma adrenocorticotropic hormone (ACTH) and free cortisol in urine were elevated to 220 pg/mL (normal, 9 to 52 pg/mL) and 793 mg/d (normal, 30 to 100 mg/d), respectively. Blood concentration of corticotropin-releasing factor was 13.8 pg/mL (normal, ,40 pg/mL). Chest radiographs and computed tomographic examinations showed an enlarged thymic gland and normal-sized adrenal glands. Venous samplings in the superior and inferior vena cava at several levels showed markedly increased plasma atrial natriuretic peptide concentrations near the thymic tumor (from 120 to 620 pg/mL). By contrast, plasma ACTH concentrations were constant at all sites sampled. Pathologic study results were compatible with carcinoid. Immunohistochemical staining for atrial natriuretic peptides and ACTH in the dissected tumor tissue showed several cells to be positively stained for the peptides. No ACTH-containing cells were detected. After the tumor was ...
TY - JOUR. T1 - Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension. AU - Campese, Vito M.. AU - Tawadrous, Medhat. AU - Bigazzi, Roberto. AU - Bianchi, Stefano. AU - Mann, Amardeep S.. AU - Oparil, Suzanne. AU - Raij, Leopoldo. PY - 1996/9. Y1 - 1996/9. N2 - In response to a high salt intake, salt-sensitive hypertensive individuals retain more sodium and manifest a rise in blood pressure greater than that in salt-resistant individuals. In this study, we tested whether salt sensitivity might be related at least in part to reduced secretion of atrial natriuretic peptide (ANP) or to abnormal nitric oxide production. We measured plasma ANP and NO2+NO3 in 7 normotensive individuals and 13 salt- sensitive and 14 salt-resistant blacks with essential hypertension under conditions of low (10 mEq/d) and high (250 mEq/d) salt intake. To evaluate possible racial differences in ANP secretion, we also measured plasma ANP in 6 salt-sensitive and 8 salt-resistant hypertensive ...
TY - JOUR. T1 - Exertional Changes in Circulating Cardiac Natriuretic Peptides in Patients with Suggested Coronary Artery Disease. AU - Bergeron, Sébastien. AU - Møller, Jacob E.. AU - Bailey, Kent R.. AU - Chen, Horng H.. AU - Burnett, John C.. AU - Pellikka, Patricia A.. PY - 2006/6/1. Y1 - 2006/6/1. N2 - Background: We measured plasma brain natriuretic peptide (BNP) and N-terminal atrial natriuretic peptide (ANP) levels before and after exercise stress testing and correlated results with echocardiographic evidence of ischemia. Methods: Sixty patients with left ventricular ejection fraction greater than 50% referred for clinically indicated exercise echocardiogram were studied. Peptides were measured at rest and 5 minutes after symptom-limited exercise. Results: Echocardiography was positive for ischemia in 19 (32%). With exercise, ANP level increased in all 60 patients (median at rest 2501 [799-6440]-3167 [977-8563] pg/mL after exercise [P , .0001]). BNP increased in 54 patients (90%) (19 ...
TY - JOUR. T1 - Atrial natriuretic peptide in hypothyroidism. AU - Zimmerman, R. S.. AU - Gharib, H.. AU - Zimmerman, D.. AU - Heublein, D.. AU - Burnett, J. C.. PY - 1987/2. Y1 - 1987/2. N2 - The effect of hypothyroidism on circulating levels of atrial natriuretic peptide (ANP) was studied in 11 hypothyroid patients (aged 11-65 yr; mean, 31 yr) and 13 normal subjects (aged 28-39 yr; mean, 32 yr). Plasma ANP was 32 ± 9 (±sd) pg/ml in normal subjects and 20 ± 5 pg/ml in the hypothyroid patients (P , 0.005). In 7 hypothyroid patients, plasma ANP levels were measured after 10-14 weeks of l-T4 therapy. ANP increased from 22 ± 5 to 46 ± 18 pg/ml (P , 0.02), along with an increase in mean serum T4 from 0.6 ± 0.5 to 8.1 ± 2.5 μg/dl (P , 0.001). Thus, hypothyroidism is characterized by decreased circulating levels of ANP which are reversed by l-T4 therapy.. AB - The effect of hypothyroidism on circulating levels of atrial natriuretic peptide (ANP) was studied in 11 hypothyroid patients (aged ...
The aim of the present study was to determine whether left atrial size--a likely indicator of atrial stretching--correlates with the plasma concentration of atrial natriuretic peptide and whether this relation is different in patients in sinus rhythm and in those with atrial fibrillation. Arterial plasma concentrations of immunoreactive atrial natriuretic peptide (ir-ANP), adrenaline, noradrenaline, aldosterone, and vasopressin were measured in 13 patients in sinus rhythm without apparent heart failure and in 13 patients in atrial fibrillation. The two groups were matched for left atrial diameter and the ratio of the left atrial diameter to the diameter of the aortic root (assessed by echocardiography). There were no significant differences in age, heart rate, blood pressure, or left ventricular end diastolic diameter between the two groups. Left atrial diameters varied from 33 to 60 mm. The mean (SD) plasma concentration of ir-ANP was significantly higher (35 (21) pmol/l) in the patients with ...
SWISS-MODEL Template Library (SMTL) entry for 7brj.1. Atrial Natriuretic Peptide Receptor complexed with deletion mutant of human Atrial Natriuretic Peptide[7-28]
The influence of physiological cardiac hypertrophy on the concentration of plasma atrial natriuretic peptide was studied in six male athletes and six normally active, matched control men. They were examined by echocardiography during a graded exercise test on a bicycle ergometer. Plasma atrial natriuretic peptide was measured at rest, at each workload until exhaustion, and 15 and 30 minutes after the exercise test. Echocardiography showed that the athletes had a significantly larger left atrium, left ventricular end diastolic diameter, left ventricular posterior wall, interventricular septum, left ventricular ejection fraction, and left ventricular mass than the controls. The athletes performed significantly more work than the control group--325 W v 277 W. The plasma concentration of atrial natriuretic peptide rose by a mean factor of 2.76 (range 1.78-4.28) in all men from rest to maximum exercise. There were no differences between the athletes and the controls in the concentrations of plasma ...
Synonyms for Atrial natriuretic peptide in Free Thesaurus. Antonyms for Atrial natriuretic peptide. 4 words related to peptide: amide, fibrinopeptide, polypeptide, endorphin. What are synonyms for Atrial natriuretic peptide?
The effects of acute volume expansion and acute salt loading on the plasma levels of immunoreactive atrial natriuretic peptides (ir-ANPs) were investigated in conscious adult (16 weeks) Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Basal plasma concentrations of ir-ANPs were similar (108 +/- 9 pg/ml and 105 +/- 8 pg/ml, respectively) in hypertensive and normotensive rats. In both strains mean arterial pressure, heart rate and plasma catecholamines were unaltered by acute volume expansion but significantly elevated by acute salt loading. However, both acute volume expansion and acute salt loading increased plasma concentrations of ir-ANPs similarily in SHR and WKY rats, independent of blood pressure or plasma catecholamine levels. Our findings show that chronic hypertension in SHR does not result in changes in basal or VOL- and SAL-stimulated levels of circulating ir-ANPs.
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திறன்மிகு நாள விரிப்பியான (Vasodilator) இதயியச் சோடியச்சிறுநீர்மைப் புரதக்கூறு [Atrial natriuretic peptide; (ANP), atrial natriuretic factor; (ANF), atrial natriuretic hormone; (ANH), Cardionatrine, Cardiodilatine; (CDD), atriopeptin], இதயத்தசைச் செல்களால் சுரக்கப்படும் புரதக்கூற்று இயக்குநீராகும்[2][3][4]. இப்புரதக்கூறானது உடலின் நீர், சோடியம், பொட்டாசியம், கொழுப்புத் திசுக்களில் உள்ள கொழுப்பு ஆகியவற்றின் சமநிலையைக் கட்டுபடுத்துவதில் ஈடுபட்டுள்ளது; இரத்தத்தின் கன அளவு ...
The clinical significance of cardiac Natriuretic Peptides (cNP) plasma levels has been shown to differ in obese and non-obese subjects. Recent lines of evidence suggest important metabolic effects of the cNP system, which has been shown to activate lipolysis, enhance lipid oxidation and mitochondrial respiration. Clinically, these properties lead to browning of white adipose tissue and to increased muscular oxidative capacity. In patients without heart disease higher cNP concentrations were observed in lean, insulin-sensitive subjects, while obese and type-2 diabetics may display reduced cNP levels.
Occurrence of a novel cardiac natriuretic peptide in rats.: We established a specific radioimmunoassay for the ring structure of iso-ANP and detected iso-ANP[
TY - JOUR. T1 - Atrial natriuretic factor modulates whole kidney tubuloglomerular feedback. AU - Margulies, K. B.. AU - Burnett, John C Jr.. PY - 1990. Y1 - 1990. N2 - Increases in sodium delivery to the distal nephron reduce glomerular filtration rate (GFR) via tubuloglomerular feedback (TGF). Central volume expansion and pharmacological concentrations of atrial natriuretic factor (ANF) are known to attenuate this response. To test the hypothesis that whole kidney TGF is attenuated by pathophysiological concentrations of ANF, hypertonic saline was given intrarenally in five dogs receiving an intravenous infusion of synthetic ANF at 20 ng·kg-1·min-1. To examine whole kidney TGF responses in heart failure, six additional dogs with acute congestive heart failure induced by rapid ventricular pacing also received intrarenal hypertonic saline. Seven sham-paced dogs served as controls. An isolated increase in circulating ANF from 26 ± 3 to 342 ± 23 pg/ml abolished the whole kidney GFR response to ...
BACKGROUND: Natriuretic peptides are currently used in the diagnosis and follow-up of patients with Chronic Heart Failure (CHF). However, it is unknown whether there are different influences of age on atrial natriuretic peptide (ANP)/N-terminal-ANP (NT-ANP) or B-type natriuretic peptide (BNP)/N-terminal-proBNP (NT-proBNP). AIMS: To compare the influence of age and gender on plasma levels of ANP/NT-ANP and BNP/NT-proBNP in CHF patients. METHODS AND RESULTS: Natriuretic peptides were measured in 311 CHF patients (68+/-8 years, 76% males, left ventricular ejection fraction (LVEF) 0.23+/-0.08). All natriuretic peptides were significantly related to age (p,0.05) on multivariate regression analysis, with partial correlation coefficients of 0.18, 0.29, 0.28 and 0.25 for ANP, NT-ANP, BNP and NT-proBNP, respectively. The relative increase of both BNP/NT-proBNP were more pronounced than of ANP/NT-ANP (p,0.01). Furthermore, the relative increase of BNP with age was markedly larger than of NT-proBNP ...
The role of atrial natriuretic factor (ANF) in modulating volume and circulatory homeostasis remains uncertain, and there has been as yet no systematic analysis of the factors promoting ANF release in humans. Since immersion in water to the neck provides a volume stimulus identical to that induced by 2 litres of saline, without plasma compositional change, immersion to the neck was used to assess the ANF response to acute central blood-volume expansion. Using a radio-immunoassay that reliably detected ANF in human plasma extracts, more than 80% of plasma immunoreactive (ir) ANF was shown to elute as a single peak on reverse-phase high performance liquid chromatography, with a retention time identical to that of the synthetic 28-residue alpha-human (alpha-h) ANF. The response of plasma irANF to 3 h of immersion in water to the neck was evaluated in four sodium-replete normal subjects; the immersion produced a prompt and marked increase in irANF in each subject, and recovery was associated with a prompt
BACKGROUND--Plasma levels of atrial natriuretic peptide (ANP) are elevated in patients with chronic obstructive pulmonary disease (COPD) and may have a role in preventing oedema formation in these patients. METHODS--Plasma ANP levels were measured in 60 patients with COPD and these measurements were related to pulmonary haemodynamics, response to treatment during exacerbations, and clinical patterns of the stable disease. RESULTS--Plasma ANP levels did not correlate significantly with right atrial or pulmonary arterial pressures but did correlate significantly with both the right ventricular end diastolic volume and right ventricular wall volume measured by magnetic resonance imaging. Oxygen (2 1/min by nasal prongs for 30 minutes) did not change the mean pulmonary arterial pressure or the level of plasma ANP. In 20 patients with an acute exacerbation of COPD plasma ANP levels were higher in those with oedema (302 (185) pg/ml) than in those without oedema (87 (43) pg/ml). Oxygen given for one ...
Title:The Emerging Role of Atrial Natriuretic Peptide in Psychiatry. VOLUME: 28 ISSUE: 1. Author(s):Donatella Marazziti, Filippo Maria Barberi, Federico Mucci*, Alessandra Maglio, Valerio DellOste and Liliana DellOsso. Affiliation:Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa. Keywords:Atrial natriuretic peptide, depression, anxiety disorder, post-traumatic stress disorder, schizophrenia, alcohol abuse, ANP.. Abstract:Introduction: Atrial natriuretic peptide ...
TY - JOUR. T1 - Physiological features of edematous dogs unresponsive to atrial natriuretic peptide. AU - Maher, Elizabeth. AU - Cernacek, Peter. AU - Levy, Mortimer. PY - 1990. Y1 - 1990. N2 - Sodium-retaining cirrhotic and chronic caval dogs with ascites show a heterogeneous natriuretic response to atrial natriuretic factor (ANF) infusions such that half will increase their urinary excretion of sodium and half will show no natriuretic response whatsoever. In these studies we have examined several physiological variables that might discriminate between these two experimental populations. We studied 22 caval dogs (11 natriuretic responders, 11 nonresponders) and 19 cirrhotic dogs (9 responders, 10 nonresponders). After an infusion of rat ANP-(1-28), 125 ng·kg-1·min-1, differences in glomerular filtration rate, blood pressure, or urinary excretion of guanosine 3,5-cyclic monophosphate (cGMP) could not differentiate between the two types of dogs. When the left kidney of nonresponding dogs in ...
The physiological actions of the atrial peptide system are discussed in relation to its potential role in the aetiology and treatment of hypertension and congestive heart failure (CHF). Atrial natriuretic factor (ANF) exerts marked natriuretic, diure
To evaluate the role of calcium in volume-induced secretion of atrial natriuretic factor (ANF), effects of verapamil and endothelin-1 (ET-1), both known to influence free intracellular calcium, were studied during saline infusion in seven conscious instrumented dogs. Fifteen minutes after intravenous injection of placebo or verapamil (0.25 mg/kg) or during continuous ET-1 infusion (at 5 ng.kg-1.min-1), saline (10% body wt) was infused during 40 min. Saline produced a rise (P less than 0.001) of plasma ANF from 28.1 +/- 6.3 to 50.4 +/- 12.9 pM after placebo, from 30.2 +/- 6.1 to 51.1 +/- 8.5 pM after verapamil, and from 31.2 +/- 6.1 to 81.0 +/- 12.9 pM with ET-1. This increase was comparable after placebo and verapamil, but was 80% greater with ET-1 (P less than 0.02). Plasma ET-1, unchanged after placebo, rose (P less than 0.001) from 1.7 +/- 0.5 to 38.3 +/- 9.2 pM with ET-1. In the three experiments, heart rate and left atrial pressure (LAP) increased (P less than 0.001) similarly. The linear ...
Learn in-depth information on Atrial Natriuretic Peptide Blood Test, on why the laboratory test is performed, specimen collected, the significance of the results, and its use in diagnosing medical conditions.
N2 - *Atrial natriuretic factor (ANP) has shown over recent decades to play an emerging role in the regulation of coronary blood flow as well as systemic blood pressure. The common polymorphism in the atrial natriuretic peptide precursor gene (NPPA), +2238 T/C, was in the previous studies associated with hypertension as well as other cardiovascular conditions. The purpose of the study was to identify the possible relationship between the +2238 T/C polymorphism and restenosis in coronary arteries stented due to the coronary artery disease (CAD ...
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BACKGROUND: The natriuretic peptides are counterregulatory hormones involved in volume homeostasis and cardiovascular remodeling. The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established.. METHODS: We prospectively studied 3346 persons without heart failure. Using proportional-hazards regression, we examined the relations of plasma B-type natriuretic peptide and N-terminal pro-atrial natriuretic peptide to the risk of death from any cause, a first major cardiovascular event, heart failure, atrial fibrillation, stroke or transient ischemic attack, and coronary heart disease.. RESULTS: During a mean follow-up of 5.2 years, 119 participants died and 79 had a first cardiovascular event. After adjustment for cardiovascular risk factors, each increment of 1 SD in log B-type natriuretic peptide levels was associated with a 27 percent increase in the risk of death (P=0.009), a 28 percent increase in the risk of a first cardiovascular ...
TY - JOUR. T1 - Comparative effects of atrial natriuretic peptide and brain natriuretic peptide on the aldosterone and pressor responses to angiotensin II in man. AU - Cargill, Robert I.. AU - Struthers, Allan D.. AU - Lipworth, Brian J.. PY - 1995. Y1 - 1995. N2 - 1. Atrial natriuretic peptide and brain natriuretic peptide have similar vasodilator and natriuretic properties, although little information is available regarding their relative effects as antagonists of the renin-angiotensin-aldosterone system. We have therefore compared how atrial natriuretic peptide and brain natriuretic peptide affect the systemic pressor and aldosterone responses to angiotensin II in eight male subjects. 2. Each subject was studied on three separate occasions, when they received a 60-min infusion of placebo, atrial natriuretic peptide (10 pmol min-1 kg-1) or brain natriuretic peptide (10 pmol min-1 kg-1), with a concomitant infusion of angiotensin II (6 ng min-1 kg-1) given for the final 30 min of the infusion ...
TY - JOUR. T1 - Atrial natriuretic factor inhibits Na-K-Cl cotransport in teleost intestine. AU - OGrady, S. M.. AU - Field, M.. AU - Nash, N. T.. AU - Rao, M. C.. PY - 1985/1/1. Y1 - 1985/1/1. N2 - Addition of atrial natriuretic factor (ANF) to the contraluminal side of the intestinal mucosa of a marine teleost, the winter flounder Pseudopleuronectes americanus, inhibits short-circuit current, net transepithelial fluxes of Na and Cl, and the unidirectional influx of Rb across the brush border membrane. This action of ANF is closely mimicked by addition of 8-bromo-guanosine 3,5-cyclic monophosphate (8-BrcGMP). In contrast to the intestine, the opercular epithelium of the flounder did not respond to the in vitro addition of either ANF or 8-BrcGMP. Because intestinal salt and water absorption diminishes when marine fish enter water of lower salinity, ANF may be an important hormonal regulator through which euryhaline fish adapt to varying salinities.. AB - Addition of atrial natriuretic factor ...
Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene. The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP). Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control. Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA). GRCh38: Ensembl release 89: ENSG00000163273 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000026241 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Entrez Gene: ...
TY - JOUR. T1 - Hemodynamic and renal excretory effects of human brain natriuretic peptide infusion in patients with congestive heart failure. T2 - A double-blind, placebo-controlled, randomized crossover trial. AU - Marcus, Lee S.. AU - Hart, Douglas. AU - Packer, Milton. AU - Yushak, Madeline. AU - Medina, Norma. AU - Danziger, Robert S.. AU - Heitjan, Daniel F.. AU - Katz, Stuart D.. PY - 1996. Y1 - 1996. N2 - Background: The pharmacological effects of infusion of human brain natriuretic peptide (hBNP) in patients with severe congestive heart failure have not been characterized previously. Methods and Results: Twenty patients with severe congestive heart failure were randomized in a double-blind, placebo-controlled, crossover trial to receive incremental 90-minute infusions of hBMP (0.003, 0.01, 0.03, and 0.1 μg/kg per minute) or placebo on 2 consecutive days. At the highest completed dose of the hBNP, mean pulmonary artery pressure decreased from 38.3±1.6 to 25.9±1.7 mm Hg; mean pulmonary ...
Frossard et al. (1997) studied an insertion/deletion (I/D) dimorphism located in the second intron of the human atrial natriuretic factor (ANF) gene among 232 UAE nationals (112 normotensives and 120 hypertensives) from the Abu Dhabi Emirate, with a view to evaluating the value of this marker in relation to hypertension. Results reveal that genotype frequencies of this I/D marker occur in Hardy-Weinberg proportions (respective genotype frequencies in the overall sample population are: II, 51%; ID, 42%; DD, 7%). No association, however, was evidenced between this dimorphic site and clinical diagnosis of essential hypertension. This suggests that: 1) this I/D dimorphism is not a useful marker to study the relationship between the ANF gene and hypertension in the UAE; and 2) variations of the ANF gene that may be in linkage disequilibrium with this marker do not play a major role in the determination of hypertension in this Arab population. Obineche et al. (2002) carried out a case-controlled study ...
TY - JOUR. T1 - C-type natriuretic peptide/guanylate cyclase B system in ATDC5 cells, a chondrogenic cell line. AU - Suda, Michio. AU - Tanaka, Kiyoshi. AU - Yasoda, Akihiro. AU - Komatsu, Yasato. AU - Chusho, Hideki. AU - Miura, Masako. AU - Tamura, Naohisa. AU - Ogawa, Yoshihiro. AU - Nakao, Kazuwa. PY - 2002/12/1. Y1 - 2002/12/1. N2 - Natriuretic peptides constitute a family of three structurally related peptides: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Particulate guanylate cyclases, GC-A, and GC-B, are the receptors for these peptides to mediate their action. ANP and BNP possess high affinities for GC-A, and CNP is the preferred ligand for GC-B. In this article, we report our study of the expression and possible role(s) of natriuretic peptides in ATDC5 cells, which represent a chondrogenic cell line. ATDC5 cells produced cyclic guanosine monophosphate (cGMP) in response to natriuretic peptides. CNP was far more potent than ANP ...
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
The measurement of natriuretic peptides for the diagnosis of heart failure has been a major breakthrough in cardiology (1)(2). B-Type natriuretic peptide (BNP) is synthesized as preproBNP mainly in the ventricular myocardium. On ventricular myocyte stretch, preproBNP is enzymatically cleaved to proBNP and released in the form of the hormonally active BNP and the inactive N-terminal proBNP (NT-proBNP). Both BNP and NT-proBNP have been shown to reflect heart failure severity (1), but studies on their sensitivity and specificity for different degrees of heart failure produced conflicting results (3)(4)(5)(6). Both BNP and NT-proBNP can be used for the diagnosis of heart failure, but there are important differences between the two tests, particularly regarding influence of age and renal function (1). In addition to glomerular filtration, BNP is eliminated from plasma mainly through natriuretic peptide receptors and degraded by neutral endopeptidases (7)(8)(9). In contrast, NT-proBNP possibly is ...
TY - JOUR. T1 - Rat brain natriuretic peptide. T2 - Isolation from rat heart and tissue distribution. AU - Nakao, Kazuwa. AU - Itoh, Hiroshi. AU - Kambayashi, Yoshikazu. AU - Hosoda, Kiminori. AU - Saito, Yoshihiko. AU - Yamada, Takayuki. AU - Mukoyama, Masashi. AU - Arai, Hiroshi. AU - Shirakami, Gotaro. AU - Suga, Shin Ichi. AU - Jougasaki, Michihisa. AU - Ogawa, Yoshihiro. AU - Inouye, Ken. AU - Imura, Hiroo. PY - 1990/6. Y1 - 1990/6. N2 - We have isolated a cardiac natriuretic peptide of 5, 000 d from atrial tissues from 500 rats and determined its amino acid sequence. The 5, 000 d atrial natriuretic factor was elucidated to be a 45 amino acid peptide with the sequence of S-Q-D-S-A-F-R-I-Q-K-R-L-R-N-S-K-M-A-H-S-S-S-C-F-G-Q-K-I-D-R-I-G-A-V-S-R-L-G-C-D-G-L-R-L-F by sequencing the native peptide and its lysyl endopeptidase digests. The sequence of this peptide was identical to the amino acid sequence (51-95) of the rat brain natriuretic peptide precursor deduced from the complementary DNA ...
Brain natriuretic peptide (BNP) was originally identified in extracts of porcine brain. However, in humans, it is produced mainly in the cardiac ventricles in response to excessive stretching of heart muscle cells (cardiomyocytes); high concentrations of BNP in the blood are a marker of heart failure. BNP is also known as natriuretic peptide B, gamma-brain natriuretic peptide, and GC-B. The release of BNP is controlled by calcium ions. BNP binds to and activates the atrial natriuretic factor receptors NPRA and NPRB, similar to atrial natriuretic peptide (ANP) but with much lower affinity. Both BNP and ANP cause a net decrease in blood volume, which lowers the bodys blood pressure. Recombinant BNP is used to treat decompensated heart failure.. ...
Brain natriuretic peptide (BNP) was originally identified in extracts of porcine brain. However, in humans, it is produced mainly in the cardiac ventricles in response to excessive stretching of heart muscle cells (cardiomyocytes); high concentrations of BNP in the blood are a marker of heart failure. BNP is also known as natriuretic peptide B, gamma-brain natriuretic peptide, and GC-B. The release of BNP is controlled by calcium ions. BNP binds to and activates the atrial natriuretic factor receptors NPRA and NPRB, similar to atrial natriuretic peptide (ANP) but with much lower affinity. Both BNP and ANP cause a net decrease in blood volume, which lowers the bodys blood pressure. Recombinant BNP is used to treat decompensated heart failure.. ...
BACKGROUND: In mammalian follicles, oocytes are arrested at the diplotene stage of prophase I until meiotic resumption following the LH surge. Recently, C-type natriuretic peptide (CNP), encoded by natriuretic peptide precursor type C (NPPC) was found to suppress mouse oocyte maturation by promoting cyclic guanosine 5-monophospate (cGMP) production in cumulus cells. However, regulation of NPPC/CNP expression during the pre-ovulatory period and their regulation by the LH surge have not been investigated.. METHODS AND RESULTS: Based on genome-wide analysis of DNA microarray data sets using samples from periovulatory ovaries, we found increases in NPPC transcripts in granulosa cells during pre-ovulatory follicle growth in mice and a rapid decline induced by the pre-ovulatory LH/hCG stimulation. Treatment of pre-ovulatory animals with hCG decreased ovarian CNP content. In isolated ovarian cells, NPPC mRNA was predominantly expressed in mural granulosa cells exhibiting similar regulation following ...
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Brain natriuretic peptide (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume. BNP is named as such because it was originally identified in extracts of pig brain. The 32-amino acid polypeptide BNP is secreted attached to a 76-amino acid N-terminal fragment in the prohormone called NT-proBNP (BNPT), which is biologically inactive. Once released, BNP binds to and activates the atrial natriuretic factor receptor NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better targets than ANP for diagnostic blood testing. The physiologic actions of BNP are similar to those of ANP and include decrease in systemic vascular resistance and central venous pressure as well as ...
TY - JOUR. T1 - Atrial natriuretic peptide inhibits angiotensin II-stimulated proliferation in fetal cardiomyocytes. AU - OTierney, P. F.. AU - Chattergoon, N. N.. AU - Louey, S.. AU - Giraud, G. D.. AU - Thornburg, K. L.. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2010/8. Y1 - 2010/8. N2 - The role of atrial natriuretic peptide (ANP) in regulating fetal cardiac growth is poorly understood. Angiotensin II (Ang II) stimulates proliferation in fetal sheep cardiomyocytes when growth is dependent on the activity of the mitogen-activated protein kinase (MAPK) and phosphoinositol-3-kinase (PI3K) pathways. We hypothesized that ANP would suppress near-term fetal cardiomyocyte proliferation in vitro and inhibit both the MAPK and PI3K pathways. Forty-eight hour 5-bromodeoxyuridine (BrdU) uptake (used as an index of proliferation) was measured in cardiomyocytes isolated from fetal sheep (135 day gestational age) in response to 100 nmAng IIwith orwithoutANP(0.003-100 nm) or 1 ...
Results: ET-1 levels were significantly higher in primary hypertension (9.93 ± 1.73 pg/ml) and renal hypertension (10.77 ± 1.50 pg/ml) in comparison to controls (4.03 ± 0.97 pg/ml), (p , 0.001, p , 0.001, respectively). NT-pro ANP concentrations in primary hypertension (71.03 ± 10.02 pg/ml), and renal hypertension (84.78 ± 6.44 pg/ml) were significantly higher than in the control group (29.62 ± 5.56 pg/ml) (p , 0.001, p , 0.001, respectively). TNF-α concentrations in primary hypertension (8.36 ± 1.60 pg/ml) and renal hypertension (7.35 ± 0.93 pg/ml) significantly exceeded concentrations in controls (4.49 ± 0.93 pg/ml), (p , 0.001, p , 0.001, respectively). ET-1 and NT-pro ANP concentrations in renal hypertension significantly exceeded those in primary hypertension (p = 0.049, p , 0.001, respectively) while TNF-α levels in renal hypertension were significantly lower than in primary hypertension (p = 0.046 ...
Natriuretic Peptides: Peptides that regulate the WATER-ELECTROLYTE BALANCE in the body, also known as natriuretic peptide hormones. Several have been sequenced (ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; C-TYPE NATRIURETIC PEPTIDE).
Hypoxic-ischaemic brain injury at birth is associated with 1-3/1000 cases of moderate to severe encephalopathy. Previously, we have shown that connexin 43 hemichannel blockade, with a specific mimetic peptide, reduced the occurrence of seizures, improved recovery of EEG power and sleep state cycling, and improved cell survival following global cerebral ischaemia. In the present study, we examined the dose response for intracerebroventricular mimetic peptide infusion (50 µmol/kg/h for 1 h, followed by 50 µmol/kg/24 h (low dose) or 50 µmol/kg/h for 25 h (high dose) or vehicle only (control group), starting 90 min after the end of ischaemia), following global cerebral ischaemia, induced by 30 min bilateral carotid artery occlusion, in near-term fetal sheep (128 ± 1 days gestation). Both peptide infusion groups were associated with a transient significant increase in EEG power between 2-12 h after ischaemia. The ischaemia-low dose group showed a significant recovery of EEG power from day five compared
Previous studies have shown that natriuretic peptide levels correlate inversely with GFR in chronic kidney disease (16,17). Investigators have postulated that higher filling pressures and wall stress play an important role in this cardiorenal link. However, in our patients with renal failure (75% acute), natriuretic peptide levels were massively elevated and could not be explained on the basis of higher filling pressures, wall stress, or depressed cardiac function. Moreover, natriuretic peptide levels ,1,000 pg/ml (BNP) and 10,000 pg/ml (NT-proBNP) were more specific for a GFR ,60 (BNP, 92%; NT-proBNP, 100%) than for a PCWP ,18 mm Hg (BNP, 42%; NT-proBNP, 60%).. To our knowledge, this study is the first to document such natriuretic peptide-hemodynamic dissociations in the setting of renal failure and suggests that renal function has a more direct effect on circulating natriuretic peptide levels than previously recognized. Moreover, the present study highlights the important limitations of these ...
Background Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor. Objective To investigate breed variation in plasma concentrations of pro-atrial natriuretic peptide 31-67 (proANP 31-67) and N-terminal B-type natriuretic peptide (NT-proBNP) in healthy dogs. Animals 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project. Methods Absence of cardiovascular disease or other clinically relevant organ-related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31-67 and NT-proBNP were measured by commercially available ELISA assays. Results Overall significant breed differences were found in proANP 31-67 (P,.0001) and NT-proBNP (P,.0001) concentrations. Pair-wise comparisons between breeds ...
Cardiac atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) modulate blood pressure and volume by activation of the receptor guanylyl cyclase-A (GC-A) and subsequent intracellular cGMP formation. Here we report what we believe to be a novel function of these peptides as paracrine regulators of vascular regeneration. In mice with systemic deletion of the GC-A gene, vascular regeneration in response to critical hind limb ischemia was severely impaired. Similar attenuation of ischemic angiogenesis was observed in mice with conditional, endothelial cell-restricted GC-A deletion (here termed EC GC-A KO mice). In contrast, smooth muscle cell-restricted GC-A ablation did not affect ischemic neovascularization. Immunohistochemistry and RT-PCR revealed BNP expression in activated satellite cells within the ischemic muscle, suggesting that local BNP elicits protective endothelial effects. Since within the heart, BNP is mainly induced in cardiomyocytes by mechanical load, we investigated ...
We have shown by Boydens chamber method that FCS and PDGF-BB potently stimulate the migration of SMCs. It appears reasonable that FCS induces SMC migration, since blood serum contains numerous growth and migration factors for vascular cells.29 30 Among these factors in serum, PDGF is known to have important roles in the development of atherosclerosis not only as a mitogen but also as a chemoattractant.2 We have confirmed the previous reports3 31 that PDGF-BB, as well as FCS, potently stimulates the migration of SMCs.. Second, we have shown that the natriuretic peptide family, especially CNP, inhibits the migration of SMCs stimulated with FCS and PDGF-BB in a concentration-dependent manner. In addition, when PDGF-BB-induced migration was separated into chemotactic and chemokinetic activities,32 natriuretic peptides strongly suppressed the chemotactic effect of PDGF-BB and modestly suppressed the chemokinetic effect of PDGF-BB. The suppression of the chemotactic effect of PDGF-BB by CNP-22 was ...
Because the thymus expresses the natriuretic peptides (NP) as well as their respective receptors, an involvement of NP in the physiology of this organ has been suggested. To evaluate functional aspects of NP in the thymus, we looked for thymic cells bearing NP receptors (Npr). Furthermore, the regulation of Npr expression by activation of cells and the influence of NP on the proliferation of thymocytes was studied. Expression of receptor messenger RNAs CmRNAs) was examined by PCR and Northern blot. Existence of functional Npr was confirmed by measurement of cGMP, the second messenger of NP. Proliferation of thymocytes upon concanavalin A (Con A) stimulation was analyzed by incorporation of [Hlthymidine. We report here that thymocytes express mRNAs for the three Npr, namely Npra, Nprb, and Nprc and that activation of Npra and Nprb increases cGMP levels. Stimulation of thymocytes with Con A (1 pg/ml, 48 h) resulted in an increase of mRNA coding for Npra, the receptor specific for atria1 ...
Medical term atrial natriuretic factor (ANF) 心房钠尿因子; 心房利尿钠因子 and its variants in English, Simplified Chinese, Traditional Chinese and Pinyin with audio pronunciation. 规范医学术语词汇
Atrial natriuretic peptides (ANP) have recently been identified in both heart and CNS. These peptides possess potent natriuretic, diuretic, and vasorelaxant activities, and are all apparently derived from a single prohormone. Specific ANP binding sites have been characterized in the adrenal zona glomerulosa and kidney cortex, and one study reported ANP binding sites in the CNS. However, a detailed examination of the localization of ANP binding sites throughout the brain has not been reported. In this study, quantitative autoradiography was employed to examine the distribution of ANP receptors in the rat CNS. The binding of (3-125I-iodotyrosyl28) rat ANP-28 to binding sites in the rat CNS was saturable, specific for ANP-related peptides, and displayed high affinity (Kd = 600 pM). When the relative concentrations of ANP binding sites were determined throughout the rat brain, the highest levels of ANP binding were localized to the circumventricular organs, including the area postrema and ...
Mark A. Oyama, Adrian Boswood, David J. Connolly, Stephen J. Ettinger, Philip R. Fox, Sonya G. Gordon, John E. Rush, D. David Sisson, Rebecca L. Stepien, Gerhard Wess, Faiez Zannad, Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease, Journal of the American Veterinary Medical Association, 2013, 243, 1, ...
Results With EA TEA, plasma proANP decreased following induction of anesthesia to the end of surgery (13%; 113±68 to 99±49 pmol/L; p=0.026), but that was not the case in the LA group (3%; 97±44 to 94±49 pmol/L; p=0.565) despite equal fluid balance (+1584±582 vs +1560±563 mL; p=0.888). Accordingly, the EA group required excessive treatment with vasopressors to maintain MAP ,60 mm Hg during surgery (2.7±2 vs 1.6±1.4 ephedrine boluses; p=0.033 and infusion of phenylephrine for 216±86 vs 58±91 min; p,0.001). Plasma proANP and fluid balance were correlated only for EA patients (r=0.44; 95% CI 0.04 to 0.91; p=0.033). ...
Principal Investigator:YAMAMOTO Tadashi, Project Period (FY):1991 - 1992, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Experimental pathology
Background: Chagas disease (CD) affects around 18 million people in Latin America. To determine the diagnostic and prognostic value of natriuretic peptides in patients with CD, we measured atrial (ANP) and brain natriuretic peptide (BNP), and compared the findings with other dilated cardiomyopathies (DCM). Methods: Blood samples were obtained from 111 CD patients, 62 patients with DCM due to other causes, and 43 gender- and age-matched healthy subjects. The CD and DCM patients were subdivided according to their NYHA classification. Natriuretic peptide concentrations were determined by immunoradiometric assays. Results: ANP and more pronounced BNP levels were increased in CD and DCM patients in relation to the NYHA class. Circulating BNP concentrations were higher in CD patients in NYHA classes I-II than in the corresponding DCM patients (p = 0.020). Importantly, ANP and BNP were already significantly elevated in CD patients without systolic ventricular dysfunction (p ≤ 0.001). In CD patients,
In the present study, blood samples were obtained at a single standardized time point, ie, in the morning on the third day of hospitalization. Because of the differences in release and metabolic clearance patterns of the natriuretic peptides, the timing of blood sampling is a crucial issue that may have affected the results of the study. Whether the relative prognostic value of the natriuretic peptides would have differed from the present results had another day of blood collection been selected remains speculative. Until larger studies have been conducted that compare the prognostic value of the natriuretic peptides in blood samples collected at multiple time points in the acute and subacute phase, our data should not be extrapolated to other time points of blood collection. However, the choice of day 3 was based on the following rationale. First, we wanted to choose a time point, based on available data in the literature, that would provide optimal reproducibility. In agreement with the ...
Relationship between natriuretic peptides and echocardiography parameters in patients with poorly regulated type 2 diabetes Magnus Dencker1, Martin Stagmo2, Mozhgan Dorkhan31Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Sciences, 2Division of Cardiology, 3Division of Diabetes and Endocrinology, Malmö University Hospital, Malmö, SwedenAbstract: This study evaluated the relationship between natriuretic peptide levels and a wide range of echocardiography parameters in a population of thirty-three patients with poorly regulated type 2 diabetes, and no known heart failure. Natriuretic peptides brain natriuretic peptide (BNP) and N-terminal prohormone BNP (NT-proBNP) were measured. Transthoracic echocardiography was performed and cardiac volumes and ejection fraction were measured. Doppler and tissue Doppler were measured and diastolic function was stratified according to recent guidelines. Very few echocardiography parameters were correlated with BNP or NT-proBNP levels.
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013 ...
Figure 1: Bradykinin metabolism and its relationship with two other vasoactive mediators: angiotensin and natriuretic peptides. ACE, angiotensin-converting enzyme; AI, angiotensin I; AII, angiotensin II; ANP, atrial natriuretic peptide; APP, aminopeptidase P; AT1, angiotensin II type I receptor; AT2, angiotensin II type II receptor; BK, bradykinin; BNP, brain natriuretic peptide; CNP, C-natruretic peptide; NEP, neutral endopeptidase 24.11; NPR-A, natriuretic peptide receptor type A; NPR-B, natriuretic peptide receptor type B ...
Salt-sensitive hypertension is a major risk factor for cardiovascular morbidity. Humans and mice with glucocorticoid receptor haploinsufficiency (GR+/−) are hypertensive, which in mice reflects activation of the renin-angiotensin-aldosterone system. Furthermore, glucocorticoid receptor (GR) gene polymorphisms associate with increased cardiovascular disease risk. Here we investigated the effect of dietary salt intake on blood pressure, heart and kidney in GR+/− mice. Adult male GR+/− mice and wild-type (WT) littermates were fed a sodium-enriched (3%Na+) or standard chow diet (0.3%Na+) for one week, after which mice were anaesthetised for measurement of blood pressure and sodium excretion. Separate cohorts were killed by decapitation and kidneys and hearts taken for histology and mRNA quantification. Cardiac atrial natriuretic peptide (ANP) mRNA levels were elevated in GR+/− mice and were markedly augmented following sodium-enriched diet [Chow:WT 100±7%, GR+/−146±8%; Sodium:WT 157±7%, ...
BACKGROUND: Previous research found precursor levels of the atrial natriuretic peptide (MR-proANP) to be promising prognostic markers. This study aims to validate these findings and describe patterns of MR-proANP in a large cohort of patients with lower respiratory tract infections. METHODS: We conducted a multicenter prospective cohort study, and measured MR-proANP in patients with lower respiratory tract infections on admission, and days 3, 5 and 7. The prognostic value of MR-proANP for predicting 30-day and 180-day mortalities was evaluated. We stratified MR-proANP levels a priori into quartiles, and compared it with severity of illness using the pneumonia severity index. RESULTS: A total of 1359 patients, including 925 with community-acquired pneumonia, were enrolled. The mortality risk at days 30 and 180 significantly increased with increasing MR-proANP quartiles ( 158-311 pmol/L, and ,311 pmol/L). This was true for low-risk, as well as high-risk subjects (pneumonia severity index classes ...
... this work led to his discovery and isolation of atrial natriuretic peptide (ANP) alternately known as atrial natriuretic factor ... "Tissue fractionation studies on the relationship between an atrial natriuretic factor and specific atrial granules". Canadian ... de Bold, A. J. (1982). "Atrial natriuretic factor of the rat heart. Studies on isolation and properties". Proceedings of the ... de Bold, AJ (1985). "Atrial natriuretic factor: a hormone produced by the heart". Science. 230 (4727): 767-70. Bibcode:1985Sci ...
Hynynen, M.; Ilmarinen, R., Tikkanen, I., Fyhrquist, F. (1993). "Plasma atrial natriuretic factor during cold-induced diuresis ...
Effects on renal hemodynamics and atrial natriuretic factor". Gastroenterology. 101 (4): 1060-7. doi:10.1016/0016-5085(91)90734 ... including atrial natriuretic factor, prostacyclin, thromboxane A2, and endotoxin. In addition to this, it has been observed ... Three independent risk factors for the development of HRS in cirrhotics have been identified: liver size, plasma renin activity ... 1993). "Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites". Gastroenterology. ...
March 1994). "Atrial natriuretic factor in hypertensive and normotensive diabetic patients". Diabetes Care. 17 (3): 195-200. ... there are no changes in perfusion or in atrial natriuretic peptide levels up until the very late stages of the disease, when ... Abordo EA, Thornalley PJ (August 1997). "Synthesis and secretion of tumour necrosis factor-alpha by human monocytic THP-1 cells ... several factors have been implicated in the pathogenesis of the disease. Etiologically, four main causes are responsible for ...
Wyss, DF; Lahm, HW; Manneberg, M; Labhardt, AM (February 1991). "Anantin--a peptide antagonist of the atrial natriuretic factor ... a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of ...
The atrioventricular canal signaling cascade involves the atrial natriuretic factor gene (ANF). This gene is one of the first ... T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans. ... T-box factor and NK2-homeobox factor binding element are involved in the repression of the atrioventricular canal without ... The molecule Tbx-2 is a transcription factor in the T box transcription factor family. Tbx2 helps form the outflow tract and ...
Kim TG, Chen J, Sadoshima J, Lee Y (2005). "Jumonji represses atrial natriuretic factor gene expression by inhibiting ... "Nitric oxide induces gene expression of jumonji and retinoblastoma 2 protein while reducing expression of atrial natriuretic ... Jarid2 (jumonji, AT rich interactive domain 2) is a protein coding gene that functions as a putative transcription factor. ... and atrial enlargement. Homozygous mutants of Jarid2 are found to die soon after birth. Overexpression of the mouse Jarid2 gene ...
Böhlen LM, de Courten M, Hafezi F, Shaw S, Riesen W, Weidmann P (June 1994). "Insulin sensitivity and atrial natriuretic factor ... c-Fos and Fra1 are both components of the transcription factor AP-1, and in the year 2000, Hafezi and his colleagues presented ...
2004). "ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells". ... 2004). "Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells ...
"Left atrial function and atrial natriuretic factor/cyclic guanosine monophosphate changes in DDD and VVI pacing modes". Am. J. ... "Total sympathetic activity and atrial natriuretic factor levels in VVI and DDD pacing with different atrioventricular delays ... and decreased left atrial total emptying fraction associated with ventricular pacing. The loss of physiologic timing of atrial ... Atrial contraction against a closed tricuspid valve can cause pulsation in the neck and abdomen, headache, cough, and jaw pain ...
Rosenzweig, Anthony; Seidman, Christine E. (1991). "Atrial Natriuretic Factor and Related Peptide Hormones". Annual Review of ... Anaritide (also known as human atrial natriuretic peptide [102-126]) is a synthetic analogue of atrial natriuretic peptide (ANP ... human atrial natriuretic factor [102-126]) infusion in the anesthetized guinea pig". Pulmonary Pharmacology. 1 (3): 119-123. ... Zietse, Robert; Schalekamp, Maarten A. (November 1988). "Effect of synthetic human atrial natriuretic peptide (102-126) in ...
"Time course of human atrial natriuretic factor release during cardiopulmonary bypass in mitral valve and coronary artery ... "Effects of prolonged infusions of atrial natriuretic peptide and isoproterenol on the mechanical and endocrine function of ... "Tumor Necrosis Factor-α Receptor 1 Is a Major Predictor of Mortality and New-Onset Heart Failure in Patients With Acute ... "Bradycardia and atrial fibrillation in patients with stable coronary artery disease treated with ivabradine: an analysis from ...
... which encodes the precursor of cardiodilatin-related peptide and atrial natriuretic factor. NPPA-AS1 is alternatively spliced. ... Long noncoding RNA Annilo T, Kepp K, Laan M (2009). "Natural antisense transcript of natriuretic peptide precursor A (NPPA): ...
... for natriuretic factors such as atrial natriuretic factor (ANF). GC-C (GUCY2C): for guanylin and uroguanylin. GC-D (GUCY2D) GC- ...
Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene ... Assisted by several other initiation factors (eIF1 and eIF1A, eIF5, eIF3, polyA binding protein) it is recruited to the 5′ end ... which leads atrial septal defect in the heart. The ability of the Kozak sequence to start translation can result in novel ... "A mutation in the Kozak sequence of GATA4 hampers translation in a family with atrial septal defects". American Journal of ...
Peptide hormones such as the atrial natriuretic factor activate membrane-bound GC, while soluble GC (sGC) is typically ...
A stimulant, atrial natriuretic factor (ANF) increases cGMP production in the kidneys, which increases function of the ... and also suggests that additional research be conducted to identify the upstream and downstream factors in CNGC-mediated signal ...
Examples are Aβ, IAPP, Atrial natriuretic factor (in isolated atrial amyloidosis), and Calcitonin (in medullary carcinoma of ... These proteins can become irregular due to genetic effects, as well as through acquired environmental factors. The four most ... In people who have inflammation caused by AA amyloidosis, tumour necrosis factor (TNF)-alpha inhibitors such as infliximab and ... Historical classification systems were based on clinical factors. Until the early 1970s, the idea of a single amyloid substance ...
They also contain neurons with receptors for angiotensin, atrial natriuretic factor, endothelin and relaxin, each of which ... Estrogen receptor (ER) has been shown to transactivate other transcription factors in this manner, despite the absence of an ... Releasing hormones (also called releasing factors) are produced in hypothalamic nuclei then transported along axons to either ... and from low-pressure atrial volume receptors, is mediated by others. In the rat, stimulation of the vagina also causes ...
R J Winquist, E P Faison, S A Waldman, K Schwartz, F Murad, and R M Rapoport (1984) Atrial natriuretic factor elicits an ... He is known for his work in atrial natriuretic factor intracellular signaling through guanylate cyclase (GC), and the relation ... His most cited articles are: SA Waldman, RM Rapoport, F Murad (1984) Atrial natriuretic factor selectively activates ... Experimental Therapeutics His early career was devoted to characterize the receptor-mediated responses to atrial natriuretic ...
Serum levels of tumor necrosis factor alpha, brain and atrial natriuretic peptide, and angiotensin-converting enzyme 2 have ...
... agonist taurine atrial natriuretic factor (ANF) tumor necrosis factor-alpha (TNF-alpha) GABA. While neurotransmission is ... The definition of a gliotransmitter is not only defined by its presence in glial cells, but is determined by other factors, ... Rivera, EJ; Goldin, A; Fulmer, N; Tavares, R; Wands, JR; de la Monte, SM (2005). "Insulin and insulin-like growth factor ...
... atrial natriuretic factor - atrial natriuretic factor receptor - Avogadro constant - axon B cell - bacteria - bacterial ... transforming growth factor - transforming growth factor alpha - transforming growth factor beta - transforming growth factor ... peptide elongation factor - peptide elongation factor tu - peptide fragment - peptide initiation factor - peptide receptor - ... nerve growth factor - nerve growth factor receptor - nerve tissue protein - nerve tissue protein S 100 - nervous system - ...
... a component of the EarthScope USArray project Atrial natriuretic peptide, or atrial natriuretic factor, a hormone America Needs ... or anti-nuclear factor in blood Array Network Facility, ...
Serine/threonine-specific protein kinase, as in bone morphogenetic protein Guanylate cyclase, as in atrial natriuretic factor ... Examples of the enzymatic activity include: Receptor tyrosine kinase, as in fibroblast growth factor receptor. Most enzyme- ... Alexander SP, Mathie A, Peters JA (February 2007). "Catalytic receptors: Natriuretic peptide family". Br. J. Pharmacol. 150 ...
... such as atrial natriuretic factor eventually leading to left ventricular hypertrophy which often progresses to heart failure. ... Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former ... "The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts". J. Mol. Cell ... Zhou J, Tan T, Tian Y, Zheng B, Ou JH, Huang EJ, Yen TS (July 2011). "Krüppel-like factor 15 activates hepatitis B virus gene ...
... natriuretic peptides MeSH D06.472.699.584.500 - atrial natriuretic factor MeSH D06.472.699.584.625 - natriuretic peptide, brain ... epidermal growth factor MeSH D06.472.317.400 - gastric inhibitory polypeptide MeSH D06.472.317.410 - gastrin-releasing peptide ... thymic factor, circulating MeSH D06.472.910.800 - thymopoietins MeSH D06.472.910.800.850 - thymopentin MeSH D06.472.910.850 - ... MeSH D06.472.699.584.750 - natriuretic peptide, c-type MeSH D06.472.699.587 - pancreatic polypeptide MeSH D06.472.699.590 - ...
... atrial natriuretic factor MeSH D08.811.520.650.800 - phosphatidylinositol diacylglycerol-lyase MeSH D08.811.600.075 - ... factor viia MeSH D08.811.277.656.300.760.310 - factor ixa MeSH D08.811.277.656.300.760.315 - factor xa MeSH D08.811.277.656. ... complement factor b MeSH D08.811.277.656.300.760.200 - complement factor d MeSH D08.811.277.656.300.760.210 - complement factor ... 300.760.320 - factor xia MeSH D08.811.277.656.300.760.324 - factor xiia MeSH D08.811.277.656.300.760.353 - furin MeSH D08.811. ...
Serine/threonine-specific protein kinase, as in bone morphogenetic protein Guanylate cyclase, as in atrial natriuretic factor ... Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact ... fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its ... The mating factor peptide may bind to a cell surface receptor on other yeast cells and induce them to prepare for mating. Cell ...
Silencer Element-Neuron-Restrictive Silencer Factor System Regulates Basal and Endothelin 1-Inducible Atrial Natriuretic ... Current research has linked RE1/NRSE activity with the regulation of the expression of the atrial natriuretic peptide (ANP) ... "Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its ... The best example of this is the Neuronal-Restrictive Silencer Factor (NRSF) that is produced by the REST gene. The REST gene ...
... such as atrial natriuretic peptide (ANP) for the former[48] and transforming growth factor-β (TGF-β) for the latter.[49] Also, ... Endothelial cells are responsible for releasing vasoconstriction and vasodilator factors, thus modifying tone. Vascular tone is ... influence of cell and culture-related factors on Caco-2 cell functional characteristics". Cell Biology and Toxicology. 21 (1): ...
Vesely DL, Chiou S, Douglass MA, McCormick MT, Rodriguez-Paz G, Schocken DD (March 1996). "Atrial natriuretic peptides ... Besides aging, there are no major risk factors known for BPPV, although previous episodes of head trauma, or the inner ear ... Proposed mechanisms linking the two are genetic factors and vascular damage to the labyrinth. Although BPPV can occur at any ...
... and atrial natriuretic peptide. Some are intended to treat heart failure. Sacubitril/valsartan (Entresto/LCZ696), which has ... Declining neprilysin activity with increasing age may also be explained by oxidative damage, known to be a causative factor in ... and atrial natriuretic peptide. Associations have been observed between neprilysin expression and various types of cancer; ... Venugopal J (2003). "Pharmacological modulation of the natriuretic peptide system". Expert Opinion on Therapeutic Patents. 13 ( ...
They include the chemokine CCL20, atrial natriuretic peptide (ANP), specific odorants, natriuretic peptide type C (NPPC), and ... Sperm attraction to a follicular factor(s) correlates with human egg fertilizability. Proc. Natl. Acad. Sci. U.S.A. 88, 2840- ... Zamir, N., Riven-Kreitman, R., Manor, M., Makler, A., Blumberg, S., Ralt, D. and Eisenbach, M. (1993) Atrial natriuretic ... Kong, N., Xu, X., Zhang, Y., Wang, Y., Hao, X., Zhao, Y., Qiao, J., Xia, G. and Zhang, M. (2017) Natriuretic peptide type C ...
Beever R (July 2009). "Far-infrared saunas for treatment of cardiovascular risk factors: summary of published evidence". ... left atrial diameter, systolic blood pressure, or diastolic blood pressure. The review also rated the quality of evidence for ... was associated with a significant reduction in brain natriuretic peptide (BNP - a marker of heart failure progression) and ...
"Glucocorticoids improve renal responsiveness to atrial natriuretic peptide by up-regulating natriuretic peptide receptor-A ... The major mechanism for this immunosuppression is through inhibition of nuclear factor kappa-light-chain-enhancer of activated ... to assist in the normalization of extracellular fluid volume by regulating body's action to atrial natriuretic peptide (ANP). ... Inhibition of this transcription factor, therefore, blunts the capacity of the immune system to mount a response. ...
Age ≥ 65 years? Yes (+1) ≥ 3 Risk Factors for CAD*? Yes (+1) Known CAD (stenosis ≥ 50%)? Yes (+1) ASA Use in Past 7d? Yes (+1) ... History of atrial fibrillation? Yes (+1) Coronary artery disease? Yes (+1) eGFR < 60 ml/min/1.73*m2? Yes (+1) Urine albumin-to- ... and Elevated N-Terminal Prohormone Brain Natriuretic Peptide. TRANSLATE-TIMI 70 is a phase 2b trial testing multiple doses of ... SEPIA-ACS-TIMI 42 evaluated the efficacy and safety of otamixaban, a direct factor Xa inhibitor, in patients with non-ST- ...
adrenocorticotropic hormone (ACTH) adropin amylin angiotensin atrial natriuretic peptide (ANP) calcitonin cholecystokinin (CCK ... Some peptide/protein hormones (angiotensin II, basic fibroblast growth factor-2, parathyroid hormone-related protein) also ...
There are three distinct atrial natriuretic factor receptors identified so far in mammals: natriuretic peptide receptors 1, 2, ... An atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide. NPRA and NPRB are linked to guanylyl ... Atrial+Natriuretic+Factor+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... where vascular smooth muscle will bind ANP released as a result of increasing right atrial pressure and will cause the walls of ...
Hypertension is a risk factor for all clinical manifestations of atherosclerosis since it is a risk factor for atherosclerosis ... Wachtell K, Devereux RB, Lyle PA, Okin PM, Gerdts E (December 2008). "The left atrium, atrial fibrillation, and the risk of ... Parekh N, Maisel AS (March 2009). "Utility of B-natriuretic peptide in the evaluation of left ventricular diastolic function ... Besides diabetes, other factors that may also increase high blood pressure include obesity, insulin resistance and high ...
This causes heart muscle cells to secrete the hormone atrial natriuretic peptide (ANP) into the blood. This acts on the kidneys ... The partial pressure of carbon dioxide is more of a deciding factor in the monitoring of pH. However, at high altitude (above ... However, the compensating mechanisms eventually wear out or are disrupted by a new complicating factor (such as the advent of a ... Thus, nutrients have become the limiting factor, and plankton levels have actually fallen over the past 50 years, not risen. As ...
Abnormal atrial natriuretic peptide (ANP) levels Elevated cholesterol Premature atrial contractions are typically diagnosed ... Healy, Jeff (2003). "Atrial fibrillation: hypertension as a causative agent, risk factor for complications, and potential ... Premature atrial contraction (PAC), also known as atrial premature complexes (APC) or atrial premature beats (APB), are a ... Often, hypertension goes hand in hand with various atrial fibrillations including premature atrial contractions (PACs). ...
... as well as hyponatremia due to overproduction of antidiuretic hormone or atrial natriuretic peptide. Around a third of people ... Vaping may be a risk factor for lung cancer, but less than that of cigarettes, and further research is necessary due to the ... It is one of the factors affecting both the prognosis and the potential treatment of lung cancer. SCLC is typically staged with ... These cases are often caused by a combination of genetic factors and exposure to radon gas, asbestos, second-hand smoke, or ...
... and atrial natriuretic peptide, among others. Filtration, which takes place at the renal corpuscle, is the process by which ... The two factors work together to return the plasma osmolality to its normal levels. Various calculations and methods are used ... "Normal kidney size and its influencing factors - a 64-slice MDCT study of 1.040 asymptomatic patients". BMC Urology. 9 (1): 19 ...
Atrial contraction is responsible for around 20% of the total filling blood volume. (In atrial fibrillation, this additional 20 ... There are particular factors unique to HFpEF that must be accounted for with therapy. Unfortunately, currently available ... Ability to perform daily tasks, hemodynamic status, kidney function, electrolyte balance, and serum natriuretic peptide levels ... Left atrial and pulmonary venous pressure increases in HFpEF due to diastolic insufficiency thus increasing pulmonary artery ...
In atrial fibrillation, electrical activity in the atrium is severely disturbed and is therefore not a reliable basis for the ... a factor associated with a poor prognosis. The guidelines issued by the European Society of Cardiology (ESC) in 2016, mention ... and brain natriuretic peptide (BNP) levels. Mortality rates were significantly lower than predicted at year 1, and lower than ... This also applies to other diseases involving severe disturbance in electrical atrial sensing. Requests have been raised in ...
For example:[citation needed] Natriuretic peptide - Both B-type natriuretic peptide (BNP) and N-terminal Pro BNP can be applied ... The most common type of cardiac arrhythmia is atrial fibrillation.[citation needed] Many anti-arrhythmic drugs have side ... Primary prevention of atherosclerosis is controlling the risk factors: healthy eating, exercise, treatment for hypertension and ... MUZYKA, BRIAN C. (1999). "Atrial Fibrillation and ITS Relationship to Dental Care". The Journal of the American Dental ...
"Atrial Natriuretic Factor". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. Z. * 0-9 ...
Karthikeyan G, Singhi S. Atrial natriuretic factor and neonatal body fluid homeostasis. Indian Journal of Pediatrics. 1997 Nov- ...
Effect of atrial natriuretic factor on arterial baroreceptor contrc of heart rate and blood pressure in conscious rats. In: ... Effect of atrial natriuretic factor on arterial baroreceptor contrc of heart rate and blood pressure in conscious rats. / ... The effects of atrial natriuretic factor (ANF) on arterial baroreceptor control of heart rate and of blood pressure were ... Effect of atrial natriuretic factor on arterial baroreceptor contrc of heart rate and blood pressure in conscious rats. ...
"Atrial Natriuretic Factor". Getting a G--RRP on regulated exocytosis in the heart.. A study by Rybkin et al. (see p. 527) ... The low-molecular-weight GTP-binding protein RhoA mediates hypertrophic growth and atrial natriuretic factor (ANF) gene ... p38 Mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a ... Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt.. This study ...
Atrial Natriuretic Factor * Guanylate Cyclase * Receptors, Atrial Natriuretic Factor * atrial natriuretic factor receptor A ... Atrial natriuretic peptide (ANP) is released from the heart in response to atrial stretch and is thought to mediate its ... Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide Nature. 1995 Nov 2; ... natriuretic and vaso-relaxant effects through the guanylyl cyclase-A receptor (GC-A). Here we report that disruption of the GC- ...
Brands, M. W. ; Freeman, R. H. / Aldosterone and renin inhibition by atrial natriuretic factor in potassium-loaded rats. In: ... Aldosterone and renin inhibition by atrial natriuretic factor in potassium-loaded rats. / Brands, M. W.; Freeman, R. H. ... Brands, M. W., & Freeman, R. H. (1989). Aldosterone and renin inhibition by atrial natriuretic factor in potassium-loaded rats ... Brands, MW & Freeman, RH 1989, Aldosterone and renin inhibition by atrial natriuretic factor in potassium-loaded rats, ...
The precursor protein is atrial natriuretic factor (ANF), a hormone controlling salt and water homeostasis that is synthesized ... 36] Imaging and some biomarkers like N-terminal pro-brain natriuretic peptide (NT-proBNP), B-type natriuretic peptide (BNP), ... Tumor necrosis factor-alpha (TNF-alpha) is also thought to be involved in amyloid deposition. [29] Aggressive use of newer ... Isolated atrial amyloidosis and the importance of molecular classification. Proc (Bayl Univ Med Cent). 2013 Oct. 26(4):387-9. [ ...
Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac ... ANP is also called atrial natriuretic factor (ANF), atrial natriuretic hormone (ANH), cardionatrine, cardiodilatin (CDD), and ... Atrial+Natriuretic+Factor at the US National Library of Medicine Medical Subject Headings (MeSH) Human NPPA genome location and ... Later, the substance was purified from heart tissue by several groups and named atrial natriuretic factor (ANF) or ANP. ANP is ...
Atrial Natriuretic Factor [‎1]‎. Attitude of Health Personnel [‎18]‎. Attitude to Death [‎8]‎. ...
Atrial natriuretic peptide inhibits transforming growth factor β-induced Smad signaling and myofibroblast transformation in ... This study tested the hypothesis that activation of atrial natriuretic peptide (ANP)/cGMP/protein kinase G signaling inhibits ... We postulate that this process contributes to the antifibrogenic effects of the natriuretic peptide in heart. © 2008 American ... transforming growth factor (TGF)-β1-induced extracellular matrix expression in cardiac fibroblasts and defined the specific ...
1. Plasma concentration and atrial content of atrial natriuretic factor (ANF) were measured in rats with chronic renal failure ... Atrial natriuretic factor in chronic renal failure: studies in man and the rat.. ... Atrial Natriuretic Factor.blood. Body Weight. Creatinine.blood. Hematocrit. Humans. Kidney Failure, Chronic.metabolism. Male. ... 2. Plasma ANF was higher, and atrial ANF content lower in rats with renal failure when compared with sham-operated controls. 3 ...
Tag Archives: Atrial Natriuretic Factor 1-29) General Rationale Increased activity of Ca2+/calmodulin-dependent protein kinase ... em P /em 0.05 ** Atrial Natriuretic Factor (1-29), chicken manufacture em P /em 0.01 versus corresponding sham, ### em P /em ... Open Atrial Natriuretic Factor (1-29), chicken manufacture up in another window Figure 5 Increased CaMKII phosphorylation of ... from the S2808 site on RyR2 trended to improve both in S2814A and WT mice within the later on phases Atrial Natriuretic Factor ...
... atrial natriuretic factor in the fetus was immunoneutralized by an intravenous bolus injection of an atrial natriuretic factor ... atrial natriuretic factor in the fetus was immunoneutralized by an intravenous bolus injection of an atrial natriuretic factor ... atrial natriuretic factor in the fetus was immunoneutralized by an intravenous bolus injection of an atrial natriuretic factor ... atrial natriuretic factor in the fetus was immunoneutralized by an intravenous bolus injection of an atrial natriuretic factor ...
Receptors, Atrial Natriuretic Factor / genetics * Receptors, Atrial Natriuretic Factor / metabolism * Repressor Proteins / ...
The precursor protein is atrial natriuretic factor (ANF), a hormone controlling salt and water homeostasis that is synthesized ... 36] Imaging and some biomarkers like N-terminal pro-brain natriuretic peptide (NT-proBNP), B-type natriuretic peptide (BNP), ... Tumor necrosis factor-alpha (TNF-alpha) is also thought to be involved in amyloid deposition. [29] Aggressive use of newer ... Isolated atrial amyloidosis and the importance of molecular classification. Proc (Bayl Univ Med Cent). 2013 Oct. 26(4):387-9. [ ...
Atrial natriuretic factor (1). * BLK+PAK1 + PAK2 + PAK3+ROR gamma+MAP4K6+alpha Tubulin+CaMKII+PHKG2+MAP4K5+MAP4K3/GLK (1). ...
Dive into the research topics of Mechanism for decrease in cardiac output with atrial natriuretic peptide in dogs. Together ... Mechanism for decrease in cardiac output with atrial natriuretic peptide in dogs. ... Atrial Natriuretic Factor 100% * Atrial Pressure 21% * Blood Circulation 21% * Blood Pressure 11% ...
Atrial Natriuretic Factor (ANF). *Atrial wall stretches with increased Blood Volumes and releases ANF ... Factors stimulating Granular cell Renin release. *Sympathetic System stimulation (Beta 1 Adrenergic Receptors) ... Blood Flow is impacted by normal secondary factors. *Lung inspiration (and negative chest pressure) increases venous return ... CCS Symptom Severity in Atrial Fibrillation Scale Central Venous Pressure CHAD Score CHADS2-VASc Score Chest Wall Pain ...
102000002723 Atrial Natriuretic Factor Human genes 0.000 description 1 * 101800001288 Atrial natriuretic factor Proteins 0.000 ... NPL 54: McDonough, P. M. & Glembotski, C. C. Induction of atrial natriuretic factor and myosin light chain-2 gene expression in ... 101800001866 Atrial natriuretic peptide Proteins 0.000 description 1 * 238000000846 Bartletts test Methods 0.000 description 1 ... 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 description 1 * 241000269370 Xenopus ,genus, ...
Renal perfusion appears to be protected by vasodilators, including prostaglandins E2 and I2 and atrial natriuretic factor. ... Increased resistance across the sinusoidal vascular bed of the liver is caused by fixed factors and dynamic factors. Two thirds ... may become activated into collagen-forming cells by a variety of paracrine factors. Such factors may be released by hepatocytes ... Clarification of risk factors for abdominal operations in patients with hepatic cirrhosis. Ann Surg. 1984 Jun. 199(6):648-55. [ ...
atrial natriuretic factor (1) * blood pressure (1) * body mass index procedure (1) ... The Atrial Natriuretic Peptide Genetic Variant rs5068 Is Associated With a Favorable Cardiometabolic Phenotype in a ...
Atrial natriu-retic factor. Sodium excretion by kidneys, BP. Monocytes and macrop-hages ...
Atrial natriuretic factor production during upright exercise. Cardiology 1990;77:433-442. ... Factors influencing P̄pa during exercise. P̄pa during exercise is affected by workload. According to studies in which subjects ... We considered factors that might have an impact on P̄pa, such as posture, workload, age, geographic origin and sex. We found ... Kessler R, Faller M, Fourgaut G, et al. Predictive factors of hospitalization for acute exacerbation in a series of 64 patients ...
More studies needed to look at dopamine, mannitol, atrial natriuretic peptide, growth factors, and pentoxifylline for treatment ... Risk Factors. *Decreased renal perfusion due to medication effects: NSAIDs, angiotensin-converting enzyme (ACE) inhibitors, ... Risk factors for prerenal disease: hypovolemia, hypotension, and third space sequestration (e.g., heart failure and cirrhosis) ... Additional risk factors: male sex, elderly, those with comorbid conditions, mechanical ventilation, multiorgan dysfunction/ ...
Atrial natriuretic factor release in postoperative cardiothoracic surgical patients. Ashcroft, G. P., Entwisle, S. J., Campbell ... ENHANCEMENT OF THE EXPRESSION OF EOSINOPHIL IGE RECEPTOR (FC-EPSILON-R2) AND ITS FUNCTION BY PLATELET-ACTIVATING FACTOR. Walsh ...
AAC abdominal aortic constriction, TMZ trimetazidine, ANF atrial natriuretic factor, MHC-β β myosin heavy chain; n = 4~6 per ... for subsequent analysis of the mRNA levels of myocardial hypertrophy-related genes including atrial natriuretic factor (ANF) ... The results of early studies indicated that NPY is an important neurohormonal factor that may function as a key regulator of ... Therefore, we chose 7 days of AAC as the main exposure factor. The changes in myocardial metabolism remodeling and potential ...
atrial natriuretic factor receptor A Medicine & Life Sciences 32% * atrial natriuretic factor receptor B Medicine & Life ... Natriuretic peptide receptors A (NPR-A) and B (NPR-B) mediate most effects of natriuretic peptides by synthesizing cGMP. ATP ... N2 - Natriuretic peptide receptors A (NPR-A) and B (NPR-B) mediate most effects of natriuretic peptides by synthesizing cGMP. ... AB - Natriuretic peptide receptors A (NPR-A) and B (NPR-B) mediate most effects of natriuretic peptides by synthesizing cGMP. ...
... the role of urinary 5-hydroxyindoleacetic acid excretion and plasma levels of atrial natriuretic peptide, transforming growth ... Prognostic Factors. Factors that determine the clinical course and outcome of patients with GI carcinoid tumors are complex and ... Various therapies targeting vascular endothelial growth factor (VEGF), platelet-derived growth factor receptor, and mammalian ... the role of urinary 5-hydroxyindoleacetic acid excretion and plasma levels of atrial natriuretic peptide, transforming growth ...
  • NPPA variants affect plasma ANP concentrations, blood pressure levels, and cardiovascular diseases such as atrial fibrillation (AF). (wikipedia.org)
  • The most common precipitating factors are supraventricular tachycardias in children and atrial fibrillation in adults. (aerzteblatt.de)
  • Recent studies have shown that the causal significance of atrial fibrillation in otherwise unexplained LVSD is underappreciated. (aerzteblatt.de)
  • What is striking in more recent treatment studies is that approximately one third of patients with atrial fibrillation and systolic heart failure exhibited primarily idiopathic LVSD and that arrhythmia-induced cardiomyopathy, or a relevant component of this disease, was detected in 58% 88% of cases ( 11 , 12 ). (aerzteblatt.de)
  • Atrial fibrillation can be circumvented with expanded padding techniques, albeit at higher radiation exposure. (pearls4peers.com)
  • OSA is detrimental to the function of endothelial cells, the specialized cells that line arteries, and OSA-related cardiovascular disease includes high blood pressure, heart attack, stroke, congestive heart failure, arrhythmia and atrial fibrillation. (healthdoc13.com)
  • Aside from hypertension (70.6 percent of women vs. 65.5 percent of men) and clinically significant valvular disease (5.3 vs. 4.6 percent), women were less likely to have a history of major cardiovascular comorbid conditions such as atrial fibrillation (32.6 vs. 36.4 percent), previous myocardial infarction (30.0 vs. 45.4 percent) and stroke (7.4 vs. 8.0 percent). (acc.org)
  • Mutations in this gene have been associated with atrial fibrillation familial type 6. (abbexa.com)
  • AZALEA - A phase 2b, multicenter, randomized, active-controlled study to evaluate the safety and tolerability of two blinded doses of the novel factor XI inhibitor abelacimab compared with open-label rivaroxaban in patients with atrial fibrillation. (timi.org)
  • Why is atrial fibrillation dangerous? (bornpottytrained.com)
  • Atrial fibrillation (AF) - This is a definition of heart rate above 150 per minute, while the pathological focus of excitation is in the atria. (bornpottytrained.com)
  • Atrial fibrillation is based on cyclic impulse transmission. (bornpottytrained.com)
  • Thromboembolism , often expressed as a stroke, may be the first sign of atrial fibrillation in those patients who have not complained or have experienced rare paroxysm attacks. (bornpottytrained.com)
  • Children can also develop atrial fibrillation. (bornpottytrained.com)
  • A large number of such foci contributes to clinically unfavorable atrial fibrillation. (bornpottytrained.com)
  • Atrial fibrillation is one of the most common arrhythmias. (bornpottytrained.com)
  • She reported a recent hospitalization 1 month prior, in March 2020, for new onset atrial fibrillation requiring cardioversion. (infectiousdiseaseadvisor.com)
  • Given Mrs B's symptoms and history of ILD, histoplasmosis, Sjögren syndrome, and atrial fibrillation, blood work and imaging were obtained. (infectiousdiseaseadvisor.com)
  • Available imaging included a recent chest radiograph performed at the time of her hospitalization for atrial fibrillation and a chest computed tomography (CT) scan obtained during the current evaluation (Figure). (infectiousdiseaseadvisor.com)
  • Atrial fibrillation (AF) is the most prevalent cardiac rhythm abnormality and is a major cause of morbidity and mortality. (edu.es)
  • Direct oral anticoagulants (DOACs) are considered advantageous compared with vitamin K antagonists in eligible atrial fibrillation patients, but the efficacy and the safety of DOACs are not well defined in the morbidly obese population. (cardiovascmed.ch)
  • We report the case of a 59-year-old woman (160 cm, 188 kg, body mass index 73.5 kg/m²) with multiple comorbidities including non-valvular atrial fibrillation, who was anticoagulated with apixaban 5 mg twice a day and who was admitted to our hospital because of acute renal failure. (cardiovascmed.ch)
  • Direct oral anticoagulants (DOACs) are considered advantageous compared with vitamin K antagonists in eligible atrial fibrillation patients [1]. (cardiovascmed.ch)
  • A recent meta-analysis showed that, compared with warfarin therapy, the use of DOACs was not associated with a higher event rate of stroke or systemic embolism in morbidly obese patients with atrial fibrillation, but with a significantly lower rate of major bleeding [2]. (cardiovascmed.ch)
  • Because of her non-valvular atrial fibrillation (CHA2DS-VASCc-Score 3), she was anticoagulated with apixaban 5 mg twice a day. (cardiovascmed.ch)
  • Atrial fibrillation (AF) is the most common arrhythmia in clinical practice, with an estimated prevalence of 0.4% to 1% in the general population, increasing with age to 8% in those above 80 years. (bmj.com)
  • Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia in clinical practice. (bmj.com)
  • A Novel Temperature-Controlled Radiofrequency Catheter Ablation System Used to Treat Patients With Paroxysmal Atrial Fibrillation. (academic-accelerator.com)
  • Objective This study reports the relationship between the postoperative oxidative stress level changes and newly onset atrial fibrillation in valvular patients. (academic-accelerator.com)
  • OBJECTIVE To compare the performance of the CHADS VASc, POAF, and HATCH scoring systems to predict new-onset atrial fibrillation after cardiac surgery. (academic-accelerator.com)
  • Postoperative atrial fibrillation is associated with higher scores on predictive indices. (academic-accelerator.com)
  • Aim: To analyse the effectiveness and safety of DOAC (direct oral anticoagulants) in non-valvular atrial fibrillation (NVAF) patients attending clinical practice. (academic-accelerator.com)
  • In the updated guide on NOAC use in patients with non-valvular atrial fibrillation, the European Heart Rhythm Association recommends against the use of the antiepileptic drug, levetiracetam, due to potential P-glycoprotein-mediated drug-drug interaction (DDI). (academic-accelerator.com)
  • BACKGROUND/PURPOSE Experience in procedures combining left atrial appendage (LAA) closure (LAAC) and catheter ablation (CA) was scarce in Chinese nonvalvular atrial fibrillation (AF) patients with high risks for stroke and bleeding. (academic-accelerator.com)
  • Combination of left atrial appendage closure and catheter ablation in a single procedure for patients with atrial fibrillation: Multicenter experience. (academic-accelerator.com)
  • This was a multicenter, prospective, observational study that assessed the characteristics of patients with Nonvalvular Atrial Fibrillation (NVAF) admitted to internal medicine units in Galicia, Spain, as well as the antithrombotic treatment prescribed prior to hospital admission. (academic-accelerator.com)
  • confirmation of atrial fibrillation by instrumental diagnostic methods. (academic-accelerator.com)
  • Natriuretic peptides (ANP, BNP, and CNP) are a family of hormone/paracrine factors that are structurally related. (wikipedia.org)
  • ANP is secreted in response to: Stretching of the atrial wall, via Atrial volume receptors Increased Sympathetic stimulation of β-adrenoceptors Increased sodium concentration (hypernatremia), though sodium concentration is not the direct stimulus for increased ANP secretion Endothelin, a potent vasoconstrictor Three types of atrial natriuretic peptide receptors have been identified on which natriuretic peptides act. (wikipedia.org)
  • Natriuretic peptide receptors A (NPR-A) and B (NPR-B) mediate most effects of natriuretic peptides by synthesizing cGMP. (umn.edu)
  • Circulating natriuretic peptides such as atrial natriuretic peptide (ANP) counterbalance the effects of hypertension and inhibit cardiac hypertrophy by activating cGMP-dependent protein kinase (PKG). (elsevier.com)
  • Umbilical vessels lack innervations, thus endothelial cells must play a role in the control of blood flow.The aim of this study was to investigate in human umbilical cord the expression of five peptides that could beinvolved in the regulation of vascular tone: Orphanin FQ, Oxytocin, Atrial Natriuretic Peptide (ANP), endothelialNitric Oxide Synthase (eNOS) and inducible Nitric Oxide Synthase (iNOS). (unipa.it)
  • Natriuretic peptides elaborated by atrial myocytes promote marked renal sodium and water excretion as a mechanism for fluid and electrolyte balance. (okstate.edu)
  • Natriuretic peptides. (cocites.com)
  • Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions. (cocites.com)
  • Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. (cocites.com)
  • Natriuretic peptides in cardiovascular diseases: current use and perspectives. (cocites.com)
  • Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. (cocites.com)
  • The natriuretic peptides (NPs) comprise a family of structurally related but genetically distinct hormones that regulate a variety of physiological processes such as cardiac growth, blood pressure, axonal path-finding and endochondral ossification leading to the formation of vertebrae and long bones. (mdc-berlin.de)
  • Peptides had been redissolved in 20 d of 5% Epidermal Growth Factor Receptor Peptide (985-996) formic acidity for liquefied chromatography-tandem mass spectrometry (LC-MS/Master of science) evaluation. (clarkfrancis.com)
  • Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. (abbexa.com)
  • This is a peptidase that degrades natriuretic peptides, bradykinin, and adromedullin. (palocedrofeed.com)
  • Seven patients with chronic heart failure were treated in single-blind crossover fashion with placebo and 10 mg, 50 mg, and 200 mg doses of the neutral endopeptidase inhibitor candoxatril to determine the effects of candoxatril on the elimination kinetics of exogenously infused atrial natriuretic peptide (ANP). (dundee.ac.uk)
  • These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood volume. (wikipedia.org)
  • They are all cell surface receptors and designated: guanylyl cyclase-A (GC-A) also known as natriuretic peptide receptor-A (NPRA/ANPA) or NPR1 guanylyl cyclase-B (GC-B) also known as natriuretic peptide receptor-B (NPRB/ANPB) or NPR2 natriuretic peptide clearance receptor (NPRC/ANPC) or NPR3 NPR-A and NPR-B have a single membrane-spanning segment with an extracellular domain that binds the ligand. (wikipedia.org)
  • Antos, LK & Potter, LR 2007, ' Adenine nucleotides decrease the apparent K m of endogenous natriuretic peptide receptors for GTP ', American Journal of Physiology - Endocrinology and Metabolism , vol. 293, no. 6, pp. (umn.edu)
  • Natriuretic peptide binding to type I receptors (NPRA and NPRB) activates their intrinsic guanylyl cyclase activity, resulting in a rapid increase in cytosolic cGMP that subsequently activates PKG. (elsevier.com)
  • The biological actions of NP are mediated by natriuretic peptide receptors (NPRs) -A, -B and -C that are located on the cell surface. (mdc-berlin.de)
  • Estrogen can bind to classic estrogen receptors (ER), ERα and ERβ, which act as ligand-gated transcription factors that bind to DNA with the help of co-activators and co-repressors and alter DNA transcription (see [ 2 ] for more details). (biomedcentral.com)
  • CONCLUSIONS: These results indicate that vessel dilator has significant beneficial diuretic, natriuretic, and hemodynamic properties in humans with congestive heart failure. (duke.edu)
  • Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that in humans is encoded by the NPPA gene. (wikipedia.org)
  • Finally, the choroid plexus produces the growth factor IGF-II and a number of transport proteins, most importantly transthyretin, that might regulate hormone transport from blood to brain. (lu.se)
  • Atrial natriuretic peptide (ANP), a hormone secreted from mammalian atria, regulates the homoeostatic balance of body fluid and blood pressure1-3. (springernature.com)
  • Atrial natriuretic factor: a hormone produced by the heart. (cocites.com)
  • Background: The natriuretic hormone peptide (NHP) 99-126 , a C-terminal peptide of pro-atrial natriuretic factor (proANF), induces bronchodilatory effects in people with asthma. (rais.is)
  • 30 minutes of moderate-to-intense aerobic exercise, like running (when you reach 70% of your maximum heart rate) has been shown to increase brain-derived neurotrophic factor (BDNF) and a peptide hormone called atrial natriuretic peptide (ANP), both of which can reduce anxiety and cognitive function while improving mood. (brightbellyhealth.com)
  • Proliferation and differentiation of cartilage cells (i.e., chondrocytes) as studied mostly in culture, is regulated by various endocrine, paracrine, and autocrine agents such as growth hormone, insulin-like growth factor-I (IGF-I), transforming growth factor (TGE-beta), and vitamin D metabolites (1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol). (agri.gov.il)
  • Avian chondrocyte proliferation is enhanced by agents which use adenosine 3':5'-cyclic monophosphate as a second messenger, such as parathyroid hormone or prostaglandin-E2, and is depressed by guanosine 3':5'-cyclic monophosphate agonists, such as atrial natriuretic peptide. (agri.gov.il)
  • Atrial natriuretic factor in chronic renal failure: studies in man and the rat. (austin.org.au)
  • 1. Plasma concentration and atrial content of atrial natriuretic factor (ANF) were measured in rats with chronic renal failure induced by subtotal nephrectomy. (austin.org.au)
  • 2. Plasma ANF was higher, and atrial ANF content lower in rats with renal failure when compared with sham-operated controls. (austin.org.au)
  • The purpose of the present study was to determine whether endogenous atrial natriuretic factor participates in the maintenance of normal vascular pressure and renal function in ovine fetuses at 128 to 130 days' gestation. (elsevier.com)
  • Cheung, CY 1991, ' Role of endogenous atrial natriuretic factor in the regulation of fetal cardiovascular and renal function ', American journal of obstetrics and gynecology , vol. 165, no. 4, pp. 1558-1567. (elsevier.com)
  • discuss the factors leading to the development of renal disease associated with chronic low-level cadmium exposure. (cdc.gov)
  • In the kidney, endothelin may function as a paracrine-autocrine factor in the regulation of renal blood flow, glomerular hemodynamics, and sodium and water homeostasis. (elsevier.com)
  • This review highlights recent research that supports an important role for endothelin as a locally produced vasoactive and natriuretic peptide in the regulation of renal hemodynamic and excretory functions. (elsevier.com)
  • Of the non-cardiac factors that play a role in the development of AF, hyperthyroidism, chronic renal disease, diabetes mellitus, chronic obstructive pulmonary disease, and obesity are distinguished. (bornpottytrained.com)
  • We report on a 59-year-old woman patient (160 cm, 188 kg, body mass index [BMI] 73.5 kg/m²) with a history of arterial hypertension, obesity hypoventilation syndrome, heart failure with preserved ejection fraction, lymphoedema, chronic ulcers, chronic alcoholism partially weaned and atrial disease associated with high-grade conductive disorders treated with a pacemaker, who was admitted to our hospital because of acute renal failure. (cardiovascmed.ch)
  • Current models suggest that growth factors or vasoactive agents produced by cardiac nonmuscle cells or by myocytes themselves in response to hemodynamic stress stimulate the expression of various genes, leading to myocyte hypertrophy. (humpath.com)
  • Natriuretic peptide (NP) genes are expressed in kidney. (elsevier.com)
  • After transfection of miR-130a-3p mimics, the expression of hypertrophic marker genes, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and β-myosin heavy chain (β-MHC), and the cell surface area were notably down-regulated compared with the control group (mimics N.C. + NE group). (bvsalud.org)
  • In order to test whether tissue lineage is organized by mechanisms at the level or chromatin structure, three cardiac phenotype-conferring genes (atrial natriuretic factor, myosin light chain-1-ventricular and α-tropomyosin) have been assessed for DNase 1 sensitivity in nuclei prepared from tissues of the developing guinea pig. (edu.au)
  • Binding of the Notch ligands Delta or Jagged to the Notch receptor instigates proteolytic cleavage which releases the Notch intracellular domain (N-IC) [ 8 ] which activates the transcription factor CBF-1 which, in turn, controls target genes such as Hes-1 [ 9 ]. (biomedcentral.com)
  • Ear drops?AutoPap: Computer-assisted cytology interpretation system?AV: Aortic valve?AV: Atrioventricular?A-V: Arteriovenous?AVERT: Atorvastatin Versus Revascularization treatment?AVID: ?AVM: Arteriovenous Malformation?AVNRT: AV nodal reentry tachycardia?AVP: Arginine vasopressin?AVR: Aortic valve replacement?AVR: Augmented V lead, right arm (ECG)?AVRT: ?AVS: Arteriovenous shunt?AWS: Alcohol withdrawal syndrome?AXR: Abdominal X ray?AZF: Azoospermia factor genes?AZT: Azidothymidine (zidovudine)?B & O: Belladonna and opium?B Bx. (kuwaitpharmacy.com)
  • For example, both of these TFs are required to fully activate mechanical stretch-responsive genes such as atrial natriuretic peptide and brain natriuretic peptide (BNP). (helsinki.fi)
  • The idiopathic AF has been associated with mutations in genes encoding both the a- and b-subunits of the voltage-gated Na+ (SCN5A, SCN1B and SCNB2) and K+ channels [KCNA5, KCNQ1, KCNE2, KCNJ2, KCNJ8 and KCNH2], producing an inhomogeneous shortening of atrial APD and refrectoriness (Chen et al. (edu.es)
  • Atrial natriuretic peptide (ANP) is released from the heart in response to atrial stretch and is thought to mediate its natriuretic and vaso-relaxant effects through the guanylyl cyclase-A receptor (GC-A). Here we report that disruption of the GC-A gene results in chronic elevations of blood pressure in mice on a normal salt diet. (nih.gov)
  • Office 2010 Crack.Association between serum estradiol levels and the natriuretic peptide response to atrial stretch. (hhinst.com)
  • This study was performed to clarify the role of estradiol levels in the endocrine modulation of hemodynamic function and the natriuretic peptide response to atrial stretch, both of which are important for the maintenance of homeostasis. (hhinst.com)
  • Although the mechanisms underlying the association between atrial distension and estradiol levels are unclear, this finding suggests that estradiol could modulate the ANP and BNP response to atrial stretch without changing the baseline BP. (hhinst.com)
  • Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes. (glembotskilab.org)
  • The low-molecular-weight GTP-binding protein RhoA mediates hypertrophic growth and atrial natriuretic factor (ANF) gene expression in neonatal rat ventricular myocytes. (glembotskilab.org)
  • Collaborative roles for c-Jun N-terminal kinase, c-Jun, serum response factor, and Sp1 in calcium-regulated myocardial gene expression. (glembotskilab.org)
  • Combinatorial actions of transcription factors in multiprotein complexes dictate gene expression profiles in cardiac development and disease. (elsevier.com)
  • Adapting to such challenges requires metabolic rearrangement, partially mediated by transcription factor control over gene expression. (carleton.ca)
  • This study was designed to determine the effects of synthetic rat atrial natriuretic factor (ANF) on plasma renin activity (PRA) and aldosterone secretion in separate groups of normal and potassium-loaded anesthetized rats. (elsevier.com)
  • Brands, MW & Freeman, RH 1989, ' Aldosterone and renin inhibition by atrial natriuretic factor in potassium-loaded rats ', American Journal of Physiology - Regulatory Integrative and Comparative Physiology , vol. 257, no. 6, pp. 26/6. (elsevier.com)
  • Freeman, R. H. / Aldosterone and renin inhibition by atrial natriuretic factor in potassium-loaded rats . (elsevier.com)
  • Such pressor effects have been linked to depressed blood and tissue levels of atrial natriuretic peptide, increased blood levels of aldosterone, and retention of sodium and water (ATSDR 1999). (cdc.gov)
  • In addition, endothelin stimulates the renin-angiotensin-aldosterone system and atrial natriuretic peptide release and inhibits arginine vasopressin-mediated water reabsorption in the inner medullary collecting duct. (elsevier.com)
  • These results suggest that polyamines are one of the cellular factors involved in regulation of ANP secretion in cultured cardiocytes. (utmb.edu)
  • This particular CellML model describes the control of atrial natriuretic peptide secretion by the left and right atria of the heart. (cellml.org)
  • In the following investigation, we have studied the role of polyamines in the regulation of atrial natriuretic peptide (ANP) using ventricular cardiocytes which in culture synthesize and secrete ANP. (utmb.edu)
  • Significant increases were found in patients with a ventricular septal defect, tricuspid valve atresia, patent ductus arteriosus, and atrial septal defect but not in those with pulmonary valve stenosis or tetralogy of Fallot. (aap.org)
  • Patients were included if they were >18 years old, had NYHA functional class II-IV HF, left ventricular ejection fraction (LVEF) ≤35 percent, elevated natriuretic peptide levels and were taking an angiotensin-converting enzyme (ACE) inhibitor or angiotensin-receptor blocker (ARB), beta-blocker (unless contraindicated or not tolerated) and mineralocorticoid receptor antagonists (MRAs), if indicated. (acc.org)
  • Zhang, D.M. and Lin Y.F. Functional Modulation of Sarcolemmal K ATP Channels by Atrial Natriuretic Peptide-Elicited Intracellular Signaling in Adult Rabbit Ventricular Cardiomyocytes . (ucdavis.edu)
  • First of all, a possible cardiac arrest, since with increased atrial contractility, ventricular activity also suffers. (bornpottytrained.com)
  • The main predictors included in the nomogram were pulse pressure, red blood cell count, left ventricular end-diastolic dimension, levels of N-terminal pro b-type natriuretic peptide, medical history, in-hospital worsening heart failure, and use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. (nature.com)
  • Uncoordinated regulation of atrial natriuretic factor and brain natriuretic peptide in lipopolysaccharide-treated rats. (phoenixbiotech.net)
  • The Hairy-related transcription factor (HRT) family of basic helix-loop-helix proteins is composed of transcriptional repressors highly expressed in the cardiovascular system. (elsevier.com)
  • The study found that when traditional risk factors for cardiovascular disease were considered, participants who slept less than six hours were 27 percent more likely to have atherosclerosis throughout the body compared with those who slept seven to eight hours. (acc.org)
  • However, the mechanisms underlying the initiation of AF in patients below 60 years of age, in whom no cardiovascular disease or any other known causal factor is present, remain to be clarified. (bmj.com)
  • However, in a subset of patients with AF younger than 60 years, routine evaluation including physical examination, laboratory tests including thyroid function, echocardiography and exercise stress testing does not reveal any cardiovascular disease or any other known causal factor. (bmj.com)
  • Although benefits of regular exercise on reduction of the risks of cardiovascular diseases have been demonstrated, 7 , 8 there is growing evidence that long-term endurance exercise may increase the risk of developing AF and atrial flutter (AFl) in middle-aged populations. (bmj.com)
  • Plasma natriuretic peptide levels and the risk of cardiovascular events and death. (vanderbilt.edu)
  • Plasma levels of epinephrine, norepinephrine, renin, C-terminal-pro-arginine-vasopressin (CT-proAVP), C-terminal-endothelin-1 and mid-regional-fragment of pro-atrial-natriuretic-peptide (MR-proANP) were analysed. (lu.se)
  • In response to atrial natriuretic factor antiserum injection, plasma angiotensin II concentrations were increased, whereas plasma arginine vasopressin concentrations were unchanged. (elsevier.com)
  • A potential role for the transcription factor ATF6. (glembotskilab.org)
  • 7 ] Although the cellular origin of NETs of the GI tract is uncertain, consistent expression of cytokeratins in NETs and the expression of the caudal-related homeodomain protein 2 (CdX2 protein), an intestinal transcription factor in endocrine tumors of the small intestine, suggests an origin from an epithelial precursor cell. (cancer.gov)
  • Genetic variation in the atrial natriuretic peptide transcription factor GATA4 modulates amygdala responsiveness in alcohol dependence. (cdc.gov)
  • Here, we have shown that HRT proteins inhibit cardiac gene transcription by interfering with GATA transcription factors that are implicated in cardiac development and hypertrophy. (elsevier.com)
  • Here, involvement of the nuclear factor of activated T-cells (NFAT) transcription factors, isoforms c1-c4, was analyzed in liver and skeletal muscle over freeze/thaw and anoxia/re-oxygenation cycles. (carleton.ca)
  • Transcription factors are pivotal regulators of gene transcription, and many diseases are associated with the deregulation of transcriptional networks. (helsinki.fi)
  • In the heart, the transcription factors GATA4 and NKX2-5 are required for cardiogenesis. (helsinki.fi)
  • Modulation of cardiac transcription factor (TF) networks by chemical entities represents another viable option for therapeutic interventions. (helsinki.fi)
  • Induced nephron progenitors are derived from adult human cells in tissue culture through transcription factor reprogramming with inducible piggyBac transposons. (vumc.org)
  • These results suggest that endogenous atrial natriuretic factor is involved in the maintenance of arterial pressure and urinary excretion in the ovine fetus. (elsevier.com)
  • The protein biomarkers are analysed in various cancerous organs for example glycoprotein CA-125, VEGF(vascular endothelial growth factor), transferrin, apolipoprotein A1 level and transthyretin levels, carcinogenic embryogenic antigen (CEA) in ovarian cancer, prostate-specific antigen, prostate acid phosphatases, and serum acid phosphatases in prostate cancer. (edubirdie.com)
  • In vitro human thyroid follicular cells have been shown to secrete vascular endothelial growth factors (VEGFs). (endocrine-abstracts.org)
  • Stabilization of the B-type natriuretic peptide mRNA in cardiac myocytes by alpha-adrenergic receptor activation: potential roles for protein kinase C and mitogen-activated protein kinase. (glembotskilab.org)
  • In cardiac myocytes, B-type natriuretic peptide (BNP) expression is induced with the rapid kinetics of a primary response gene. (glembotskilab.org)
  • Using a knock-in (KI) rat model, researchers found an AF-associated human variant in NPPA caused inflammation, fibroblast activation, atrial fibrosis, and AF in KI rats. (wikipedia.org)
  • A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. (cocites.com)
  • Later, the substance was purified from heart tissue by several groups and named atrial natriuretic factor (ANF) or ANP. (wikipedia.org)
  • Tissue levels of atrial natriuretic polypeptide (ANP) messenger RNA (ANPmRNA) and ANP in the human atrium and ventricle were measured simultaneously by the blot hybridization technique and the specific radioimmunoassay for ANP. (elsevier.com)
  • ANP mRNA concentration was determined using a competitive quantitative RT-PCR method in kidneys and Northern blot in atrial tissue. (elsevier.com)
  • Estrogen-mediated changes in another organ could, via secreted factors or other similar mechanisms, lead to changes in cardiac tissue. (biomedcentral.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (hiv-pharmacogenomics.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8) in serum, plasma, tissue homogenates and other biological fluids. (hiv-pharmacogenomics.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (hiv-pharmacogenomics.org)
  • Due to the effects of various factors (heart attack, ischemia, infection) in the muscle tissue of the heart, areas with a disturbed conductive system are formed. (bornpottytrained.com)
  • SGLT-2 inhibitors are a novel class of antidiabetic drugs which produce glycosuric and natriuretic effects by inhibiting glucose and sodium reabsorption from the proximal convoluted tubules [ 10 ]. (biomedcentral.com)
  • The heart's atria secrete atrial natriuretic peptide, which stimulates urinary sodium excretion. (pharmacy180.com)
  • The "Guyton Curves" describe the relationship between right atrial pressures and cardiac output, and they form a foundation for understanding the physiology of circulation. (cellml.org)
  • 01) but not with the right atrial size or the mean right atrial pressure. (aap.org)
  • The reason for this is congenital malformations - one ventricle, atrial septal defect, surgery associated with valve repair. (bornpottytrained.com)
  • The rheological properties of plasma and blood cells are markedly influenced by the surrounding milieu: physicochemical factors, metabolism and hormones. (iospress.com)
  • ANP is one of a family of nine structurally similar natriuretic hormones: seven are atrial in origin. (wikipedia.org)
  • Nocturnal urine production by the kidneys is based upon several factors including fluid intake and production of certain hormones. (healthdoc13.com)
  • In the high-dose group, plasma atrial natriuretic factor concentration was significantly reduced by 65 ± 14 pg/ml from basal levels of 165 ± 12 pg/ml within 10 minutes and remained reduced for the 90-minute period after the injection. (elsevier.com)
  • Urine flow rate was suppressed for as long as plasma atrial natriuretic factor concentrations were reduced. (elsevier.com)
  • We also measured heart rate variability (n = 23) and resting venous plasma norepinephrine (n = 24), epinephrine (n = 24), and atrial natriuretic peptide (ANP) (n = 14). (uea.ac.uk)
  • The plasma level of human α-atrial natriuretic peptide was measured in healthy children and patients, 1 month to 15 years of age, with congenital heart diseases. (aap.org)
  • The natriuretic peptide response to atrial distension was evaluated by the increase in plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) during atrial distension. (hhinst.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Canine Transforming Growth Factor Beta 2 (TGFb2) in samples from serum, plasma or other biological fluids. (scalegen.com)
  • Determination of Genetic Factors Associated with Response to Osteopathic Manipulative Treatment (OMT) in Individuals with Chronic Lower Back Pain (CLBP). (tdl.org)
  • Using multivariate analysis, the factors significantly associated with acute kidney injury were age, diabetes, preoperative chronic kidney disease and emergent surgery. (who.int)
  • These findings indicate that human α-atrial natriuretic peptide is released into the circulation in response to chronic atrial expansion in patients with congenital heart disease and may have an important role in volume homeostasis. (aap.org)
  • Differential effects of protein kinase C, Ras, and Raf-1 kinase on the induction of the cardiac B-type natriuretic peptide gene through a critical promoter-proximal M-CAT element. (glembotskilab.org)
  • A member of the natriuretic peptide gene family, NPPA encodes an important cardiac signaling molecule known as atrial natriuretic peptide/factor (ANP). (wikipedia.org)
  • In the heart, there are at least two groups of signals: mechanical triggers, such as stretch, and trophic triggers, such as polypeptide growth factors (IGF-1) and vasoactive agents (angiotensin II, α-adrenergic agonists). (humpath.com)
  • The discovery of a natriuretic factor (one that promotes kidney excretion of salt and water) was first reported by Adolfo José de Bold in 1981 when rat atrial extracts were found to contain a substance that increased salt and urine output in the kidney. (wikipedia.org)
  • Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. (cocites.com)
  • GARDEN is a phase 2 trial testing the effect of ponsegromab, a novel monoclonal antibody directed against growth differentiation factor (GDF)-15, on health status and physical activity in patients with heart failure and elevated circulating GDF-15 concentrations. (timi.org)
  • Let your doctor know if you have any risk factors for heart failure. (healthyheartworld.com)
  • For example, there may be a continuum from typical idiopathic PAH (IPAH) (Group 1), through atypical IPAH, to PH due to heart failure with preserved ejection fraction (HFpEF) (Group 2), on which patients have a declining precapillary component, an increasing risk factor profile, and may have declining efficacy and increasing side effects of targeted PAH therapy. (emjreviews.com)
  • p38 Mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element. (glembotskilab.org)
  • mid-regional pro-adrenomedullin (MR-proADM), mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, high-sensitivity cardiac troponin T (hs-cTnT), ST2, galectin-3, cystatin C, combined free light chains (cFLC) and high sensitivity C-reactive protein (hsCRP). (ox.ac.uk)
  • Increased expression of nerve growth factor (NGF) has been found in the myocardium suffered from ischemia and reperfusion (I/R). The pro-survival activity of NGF on ischemic heart has been supposed to be mediated by phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. (medsci.org)
  • The protein encoded by this gene belongs to the natriuretic peptide family. (abbexa.com)
  • This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. (abbexa.com)
  • Chai, Y. and Lin, Y.F. Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: Involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction . (ucdavis.edu)
  • Circulating atrial natriuretic factor in the fetus was immunoneutralized by an intravenous bolus injection of an atrial natriuretic factor antiserum at a dilution of 1:2000 (low dose, n = 7) or 1:400 (high dose, n = 6). (elsevier.com)
  • ANP is closely related to BNP (brain natriuretic peptide) and CNP (C-type natriuretic peptide), which all share a similar amino acid ring structure. (wikipedia.org)
  • We report here identification in porcine brain of a novel peptide of 26 amino-acid residues, eliciting a pharmacological spectrum very similar to that of ANP, such as natriuretic-diuretic, hypotensive and chick rectum relaxant activities. (springernature.com)
  • Thus, we have designated the peptide 'brain natriuretic peptide' (BNP). (springernature.com)
  • Nerve growth factor (NGF) is one of the representative members of the neurotrophin family, which includes brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5). (medsci.org)
  • The expression of brain natriuretic peptide(BNP), β-myosin heavy chain(β-MHC), cystathionase (CSE), miRNA-133a, calcineurin (CaN) were detected by qRT-PCR. (bvsalud.org)
  • GOLDILOX is a Phase IIB, Randomized, Double-Blinded, Placebo-Controlled Trial To Evaluate the Efficacy and Safety of MEDI6570 (a fully human monoclonal antibody against LOX-1) in Participants with a Prior Myocardial Infarction, Persistent Inflammation, and Elevated N-Terminal Prohormone Brain Natriuretic Peptide. (timi.org)
  • Atrial natriuretic factor (ANF)-RFP fluorescence expression (red) is driven by muscle-specific MEf2-Gal4. (umaryland.edu)
  • This Ca ++ release was accompanied by an increase in the production of NO. Also, overexpression of pNHP 73-102 , but not pVAX control, in phorbol myristate acetate-activated A549 cells resulted in a significant decrease in expression of a cotransfected nuclear factorκB (NFκB)-luciferase reporter. (rais.is)
  • The expression of atrial natriuretic peptide receptor in the mouse inner ear labyrinth. (nel.edu)
  • Long L, Tang Y, Xia Q, Xia Z, Liu J. The expression of atrial natriuretic peptide receptor in the mouse inner ear labyrinth. (nel.edu)
  • Enzyme-linked receptor · atrial natriuretic factor · npr1 · npr2. (luckweaver.com)
  • The NPPA gene is expressed primarily in atrial myocytes and consists of 2 introns and three exons, with translation of this gene yielding a high molecular mass 151 amino acid polypeptide known as preproANP. (wikipedia.org)
  • GH significantly increased mean insulin-like growth factor I levels from 105 +/- 11 to 304 +/- 45 micrograms/L during low dose treatment (P = 0.006) and 400 +/- 76 micrograms/L during high dose treatment (P = 0.004). (garvan.org.au)
  • After 10-min of atrial distension, serum estradiol levels were significantly lower in women than in men (1.0 +/- 0.3 vs. 2.4 +/- 0.4 pg/ml). (hhinst.com)
  • Influence of hypothermic cardiopulmonary bypass on atrial natriuretic factor levels. (uchicago.edu)
  • Anoxia activated NFATc4 in liver, leading to increased atrial natriuretic peptide levels. (carleton.ca)
  • Mean BP, pulse rate, and ANP and BNP levels did not change in response to 10-min of atrial distension. (hhinst.com)
  • Atriopeptidase specifically degrades atrial natriuretic factor. (eaglebio.com)
  • Genetic factors may play an important role in the development of essential hypertension. (muaawin.org)
  • Fibroblast growth factor 2 (FGF2) prevents apoptosis and stimulates proliferation of metanephric mesenchymal cells (MMCs). (nii.ac.jp)
  • PTTG is tumourigenic in vivo and transactivates fibroblast growth factor-2 (FGF-2). (endocrine-abstracts.org)
  • Similarly, in a cohort study of 1269 consecutive patients with atrial flutter, arrhythmia-induced cardiomyopathy was diagnosed in 56% (103/184) of cases in the subgroup with LVSD after ablation ( 13 ). (aerzteblatt.de)
  • Recent studies suggest that long-term endurance exercise may increase the incidence of AF and atrial flutter (AFl) in this population. (bmj.com)
  • Libera o de Fator Natriur tico Atrial por distens o atrial e taquicardia: 1) Vasodilata o arterial e venosa (via GMPc), 2) Inibe a libera o de noradrenalina, 3) Aumenta a sensibilidade dos baroreceptores, 4) Inibe a forma o de renina, 5) Impede a sede, secre o de aldosterona e vasopressina pela angiotensina II e 6) Natriurese e diurese. (ufc.br)
  • Using arterial tonometry, we examined the association between dynamic changes of BP and endocrine factors. (hhinst.com)
  • HRT proteins inhibited GATA-dependent transcriptional activation of cardiac gene promoters such as the atrial natriuretic factor (ANF) promoter. (elsevier.com)
  • In H9C2 cells, GRK2 overexpression increased atrial natriuretic factor (ANF) activity and enhanced phenylephrine-induced ANF response, and this is associated with an increase of NFkappaB transcriptional activity. (cnr.it)
  • It may be due to the effects of multiple other confounding factors like genetic, ecological, and lifestyle variables. (jaypeejournals.com)
  • It also calculates a multiplier factor for controlling the resistance of the afferent arterioles (AAR) of the kidneys. (cellml.org)