A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
Cell surface proteins that bind ATRIAL NATRIURETIC FACTOR with high affinity and trigger intracellular changes influencing the behavior of cells. They contain intrinsic guanylyl cyclase activity.
Endogenous or exogenous chemicals that regulate the WATER-ELECTROLYTE BALANCE in the body. They consist of peptides and non-peptide compounds.
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
Sodium excretion by URINATION.
A PEPTIDE of 22 amino acids, derived mainly from cells of VASCULAR ENDOTHELIUM. It is also found in the BRAIN, major endocrine glands, and other tissues. It shares structural homology with ATRIAL NATRIURETIC FACTOR. It has vasorelaxant activity thus is important in the regulation of vascular tone and blood flow. Several high molecular weight forms containing the 22 amino acids have been identified.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
The chambers of the heart, to which the BLOOD returns from the circulation.
Peptides that regulate the WATER-ELECTROLYTE BALANCE in the body, also known as natriuretic peptide hormones. Several have been sequenced (ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; C-TYPE NATRIURETIC PEPTIDE).
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
The hemodynamic and electrophysiological action of the HEART ATRIA.
The hollow, muscular organ that maintains the circulation of the blood.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
A ubiquitous sodium salt that is commonly used to season food.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
The circulation of the BLOOD through the vessels of the KIDNEY.
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Sense of awareness of self and of the environment.
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.
General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
Agents that promote the excretion of urine through their effects on kidney function.
Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.
Refers to animals in the period of time just after birth.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The main trunk of the systemic arteries.
The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.
Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate.
Elements of limited time intervals, contributing to particular results or situations.
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
Hypertension due to RENAL ARTERY OBSTRUCTION or compression.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
The process by which fetal Rh+ erythrocytes enter the circulation of an Rh- mother, causing her to produce IMMUNOGLOBULIN G antibodies, which can cross the placenta and destroy the erythrocytes of Rh+ fetuses. Rh isoimmunization can also be caused by BLOOD TRANSFUSION with mismatched blood.
A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The nonstriated involuntary muscle tissue of blood vessels.
Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
The active metabolite of ENALAPRIL and a potent intravenously administered angiotensin-converting enzyme inhibitor. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion.
A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
The quantity of volume or surface area of CELLS.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
Contractile activity of the MYOCARDIUM.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.
Discharge of URINE, liquid waste processed by the KIDNEY, from the body.
The measurement of an organ in volume, mass, or heaviness.
The functional units of the kidney, consisting of the glomerulus and the attached tubule.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
Tapping fluid from the subarachnoid space in the lumbar region, usually between the third and fourth lumbar vertebrae.
The rate dynamics in chemical or physical systems.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.
Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.

A low-affinity serum response element allows other transcription factors to activate inducible gene expression in cardiac myocytes. (1/2854)

Hypertrophic growth of cardiac muscle cells is induced by a variety of physiological and pathological stimuli and is associated with a number of changes, including activation of genes such as atrial natriuretic factor. We found that two serum response element (SRE)-like DNA elements, one of which does not meet the consensus sequence and binds serum response factor (SRF) with low affinity, regulate the activity of this promoter. Surprisingly, the ability to induce the promoter by two different physiologic stimuli, as well as various activated transcription factors, including SRF-VP16, was primarily dependent upon the nonconsensus rather than the consensus SRE. This SRE controls the induction of gene expression via an unusual mechanism in that it is required to allow some, but not all, active transcription factors at unrelated sites on the promoter to stimulate gene expression. Thus, in addition to regulation of SRF activity by growth stimuli, regulation of a low-affinity SRE element controls inducible gene expression by modulating the ability of other transcription factors to stimulate the transcription machinery.  (+info)

Low calorie diet enhances renal, hemodynamic, and humoral effects of exogenous atrial natriuretic peptide in obese hypertensives. (2/2854)

The expression of the natriuretic peptide clearance receptor is abundant in human and rat adipose tissue, where it is specifically inhibited by fasting. In obese hypertensives, plasma atrial natriuretic peptide (ANP) levels were found to be lower than in obese normotensives. Therefore, the increased adipose mass might influence ANP levels and/or its biological activity. The aim of the present study was to evaluate whether the humoral, hemodynamic, and renal effects of exogenous ANP in obese hypertensives might be enhanced by a very low calorie diet. Eight obese hypertensives received a bolus injection of ANP (0.6 mg/kg) after 2 weeks of a normal calorie/normal sodium diet, and blood pressure (BP), heart rate, ANP, cGMP, plasma renin activity, and aldosterone were evaluated for 2 hours before and after the injection. Diuresis and natriuresis were measured every 30 minutes. The patients then started a low calorie/normal sodium diet (510 kcal/150 mmol/d) for 4 days, and then the ANP injection protocol was repeated. The low calorie diet induced a slight weight loss (from 90.6+/-1.1 to 87. 7+/-1.2 kg; P<0.01), which was accompanied by increase of cGMP excretion (from 146.0+/-10.1 to 154.5+/-9.5 nmol/24 h; P<0.05) together with a reduction of BP (P<0.01 versus basal levels). ANP injection after diet was followed by an increase of ANP levels similar to that observed before diet, but plasma cGMP, diuresis, and natriuresis increased significantly only after diet. Similarly, the decrease of BP after ANP administration was significantly higher after diet (change in mean arterial pressure, -6.4+/-0.7 versus -4. 0+/-0.6 mm Hg; P<0.05) as well as that of aldosterone (P<0.01). These data show that a low calorie diet enhances the humoral, renal, and hemodynamic effects of ANP in obese hypertensives and confirm the importance of caloric intake in modulating the biological activity of ANP, suggesting that the natriuretic peptide system can play a role in the acute changes of natriuresis and diuresis associated with caloric restriction.  (+info)

Peri-operative changes in echocardiographic measurements and plasma atrial and brain natriuretic peptide concentrations in 3 dogs with patent ductus arteriosus. (3/2854)

Peri-operative changes in echocardiographic measurements and plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were investigated for 1 month in 3 dogs with patent ductus arteriosus (PDA). Post-operative left ventricular end-diastolic dimention and fractional shortening decreased in all cases. Pre-operatively increased plasma ANP concentrations reduced dramatically after the operation. Peri-operative changes in plasma BNP levels had slightly S-shaped curves in all cases. These observations suggest that post-operative responsiveness of ANP and cardiac function are rapid in comparison with cardiac morphological changes, and BNP has a different pathophysiological significance from ANP in dogs with PDA.  (+info)

Sperm chemotaxis. (4/2854)

Communication between spermatozoa and egg before contact by chemotaxis appears to be prevalent throughout the animal kingdom. In non-mammalian species, sperm chemotaxis to factors secreted from the egg is well documented. In mammals, sperm chemotaxis to follicular factors in vitro has been established in humans and mice. The attractants of female origin in non-mammalian species are heat-stable peptides or proteins of various sizes, or other small molecules, depending on the species. Species specificity of the attractants in non-mammalian species may vary from high species specificity, through specificity to families with no specificity within a family, to absence of specificity. The mammalian sperm attractants have not been identified but they appear to be heat-stable peptides. The claim that progesterone is the attractant for human spermatozoa has failed to be substantiated, neither have claims for other mammalian sperm attractants been verified. The molecular mechanism of sperm chemotaxis is not known. Models involving modulation of the intracellular Ca2+ concentration have been proposed for both mammalian and non-mammalian sperm chemotaxis. The physiological role of sperm chemotaxis in non-mammalian species appears to differ from that in mammals. In non-mammalian species, sperm chemotaxis strives to bring as many spermatozoa as possible to the egg. However, in mammals, the role appears to be recruitment of a selective population of capacitated ('ripe') spermatozoa to fertilize the egg.  (+info)

Physiological variability of fluid-regulation hormones in young women. (5/2854)

We tested the physiological reliability of plasma renin activity (PRA) and plasma concentrations of arginine vasopressin (P[AVP]), aldosterone (P[ALD]), and atrial natriuretic peptide (P[ANP]) in the early follicular phase and midluteal phases over the course of two menstrual cycles (n = 9 women, ages 25 +/- 1 yr). The reliability (Cronbach's alpha >/=0.80) of these hormones within a given phase of the cycle was tested 1) at rest, 2) after 2.5 h of dehydrating exercise, and 3) during a rehydration period. The mean hormone concentrations were similar within both the early follicular and midluteal phase tests; and the mean concentrations of P[ALD] and PRA for the three test conditions were significantly greater during the midluteal compared with the early follicular phase. Although Cronbach's alpha for resting and recovery P[ANP] were high (0.80 and 0.87, respectively), the resting and rehydration values for P[AVP], P[ALD], and PRA were variable between trials for the follicular (alpha from 0.49 to 0.55) and the luteal phase (alpha from 0.25 to 0. 66). Physiological reliability was better after dehydration for P[AVP] and PRA but remained low for P[ALD]. Although resting and recovery P[AVP], P[ALD], and PRA were not consistent within a given menstrual phase, the differences in the concentrations of these hormones between the different menstrual phases far exceeded the variability within the phases, indicating that the low within-phase reliability does not prevent the detection of menstrual phase-related differences in these hormonal variables.  (+info)

Cardiovascular, endocrine, and renal effects of urodilatin in normal humans. (6/2854)

Effects of urodilatin (5, 10, 20, and 40 ng. kg-1. min-1) infused over 2 h on separate study days were studied in eight normal subjects with use of a randomized, double-blind protocol. All doses decreased renal plasma flow (hippurate clearance, 13-37%) and increased fractional Li+ clearance (7-22%) and urinary Na+ excretion (by 30, 76, 136, and 99% at 5, 10, 20, and 40 ng. kg-1. min-1, respectively). Glomerular filtration rate did not increase significantly with any dose. The two lowest doses decreased cardiac output (7 and 16%) and stroke volume (10 and 20%) without changing mean arterial blood pressure and heart rate. The two highest doses elicited larger decreases in stroke volume (17 and 21%) but also decreased blood pressure (6 and 14%) and increased heart rate (15 and 38%), such that cardiac output remained unchanged. Hematocrit and plasma protein concentration increased with the three highest doses. The renin-angiotensin-aldosterone system was inhibited by the three lowest doses but activated by the hypotensive dose of 40 ng. kg-1. min-1. Plasma vasopressin increased by factors of up to 5 during infusion of the three highest doses. Atrial natriuretic peptide immunoreactivity (including urodilatin) and plasma cGMP increased dose dependently. The urinary excretion rate of albumin was elevated up to 15-fold (37 +/- 17 micrograms/min). Use of a newly developed assay revealed that baseline urinary urodilatin excretion rate was low (<10 pg/min) and that fractional excretion of urodilatin remained below 0.1%. The results indicate that even moderately natriuretic doses of urodilatin exert protracted effects on systemic hemodynamic, endocrine, and renal functions, including decreases in cardiac output and renal blood flow, without changes in arterial pressure or glomerular filtration rate, and that filtered urodilatin is almost completely removed by the renal tubules.  (+info)

Second messenger production in avian medullary nephron segments in response to peptide hormones. (7/2854)

We examined the sites of peptide hormone activation within medullary nephron segments of the house sparrow (Passer domesticus) kidney by measuring rates of hormone-induced generation of cyclic nucleotide second messenger. Thin descending limbs, thick ascending limbs, and collecting ducts had baseline activity of adenylyl cyclase that resulted in cAMP accumulation of 207 +/- 56, 147 +/- 31, and 151 +/- 41 fmol. mm-1. 30 min-1, respectively. In all segments, this activity increased 10- to 20-fold in response to forskolin. Activity of adenylyl cyclase in the thin descending limb was stimulated approximately twofold by parathyroid hormone (PTH) but not by any of the other hormones tested [arginine vasotocin (AVT), glucagon, atrial natriuretic peptide (ANP), or isoproterenol, each at 10(-6) M]. Thick ascending limb was stimulated two- to threefold by both AVT and PTH; however, glucagon and isoproterenol had no effect, and ANP stimulated neither cAMP nor cGMP accumulation. Adenylyl cyclase activity in the collecting duct was stimulated fourfold by AVT but not by the other hormones; likewise, ANP did not stimulate cGMP accumulation in this segment. These data support a tubular action of AVT and PTH in the avian renal medulla.  (+info)

cGMP-dependent and -independent inhibition of a K+ conductance by natriuretic peptides: molecular and functional studies in human proximal tubule cells. (8/2854)

In immortalized human kidney epithelial (IHKE-1) cells derived from proximal tubules, two natriuretic peptide receptors (NPR) were identified. In addition to NPR-A, which is bound by atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and urodilatin (URO), a novel form of NPR-B that might be bound by C-type natriuretic peptide (CNP) was identified using PCR. This novel splice variant of NPR-B (NPR-Bi) was also found in human kidney. Whereas ANP, BNP, and URO increased intracellular cGMP levels in IHKE-1 cells in a concentration-dependent manner, CNP had no effect on cGMP levels. To determine the physiologic responses to these agonists in IHKE-1 cells, the membrane voltage (Vm) was monitored using the slow whole-cell patch-clamp technique. ANP (10 nM), BNP (10 nM), and URO (16 nM) depolarized these cells by 3 to 4 mV (n = 47, 7, and 16, respectively), an effect that could be mimicked by 0.1 mM 8-Br-cGMP (n = 15). The effects of ANP and 8-Br-cGMP were not additive (n = 4). CNP (10 nM) also depolarized these cells, by 3+/-1 mV (n = 28), despite the absence of an increase in cellular cGMP levels, indicating a cGMP-independent mechanism. In the presence of CNP, 8-Br-cGMP further depolarized Vm significantly, by 1.6+/-0.3 mV (n = 5). The depolarizations by ANP were completely abolished in the presence of Ba2+ (1 mM, n = 4) and thus can be related to inhibition of a K+ conductance in the luminal membrane of IHKE-1 cells. The depolarizations attributable to CNP were completely blocked when genistein (10 microM, n = 6), an inhibitor of tyrosine kinases, was present. These findings indicate that natriuretic peptides regulate electrogenic transport processes via cGMP-dependent and -independent pathways that influence the Vm of IHKE-1 cells.  (+info)

1. The effect of a α-human atrial natriuretic peptide (1-28) (ANP) on human vasculature was investigated in vivo and in vitro. Possible involvement of vascular dopamine receptors and the renin-angiotensin system in the response to ANP was also studied in vivo.. 2. Forearm blood blow was measured by venous occlusion plethysmography. Isolated human blood vessels were studied using conventional organ bath techniques.. 3. ANP (0.1-1 μg/min, intra-arterially) produced a dose-dependent increase in forearm blood flow, corresponding to a 163% increase in net forearm blood flow in the study arm. This action of ANP was not antagonized by (R)-sulpiride (100 μg/min, intra-arterially), a selective vascular dopamine receptor antagonist, or 50 mg of oral captopril, an inhibitor of angiotensin-converting enzyme.. 4. ANP (1 nmol/l-1 μmol/l) produced concentration-dependent relaxation of isolated human arteries, including brachial artery, but was without effect on isolated human saphenous vein.. 5. ANP ...
TY - GEN. T1 - Acute hyperglycaemia causes elevation of plasma atrial natriuretic peptide concentrations in type 1 diabetes subjects. AU - McKenna, K. AU - Smith, D. AU - Tormey, William. AU - Thompson, CJ. PY - 1999. Y1 - 1999. M3 - Conference contribution. VL - 48. SP - A139-A139. BT - Unknown Host Publication. PB - John Wiley & Sons, Inc.. T2 - DIABETES. Y2 - 1 January 1999. ER - ...
The administration of exogenous atrial natriuretic peptide (ANP) resulted in numerous physiological responses, including a rapid natriuresis and diuresis as well as a reduction in arterial blood pressure. In order to provide a continuous supply of ANP, we used gene transfer approach to investigate the role of ANP in hypertensive rats and in normotensive animals with chronic heart failure. The human ANP gene placed under the control of RSV or CMV promoter with a 4F2 enhancer was incorporated into replication-deficient adenovirus. Expression of human ANP in cell culture or in rats was identified by RT-PCR Southern blot analysis and/or a radioimmunassay for human ANP. The results showed that a single injection of the ANP gene results in: 1) prolonged reduction of blood pressure in spontaneously hypertensive rats (SHR) and Dahl- salt sensitive (DSS) rats on a high salt diet, 2) increases in renal blood flow, glomerular filtration rate, sodium output, urine excretion and urinary cGMP levels, ...
alpha-Human atrial natriuretic peptide, a 28-amino-acid-residue peptide, was rapidly hydrolysed by pig kidney microvillar membranes in vitro, with a t1/2 of 8 min, comparable with the rate observed with angiotensins II and III. The products of hydrolysis were analysed by h.p.l.c., the pattern obtained with membranes being similar to that with purified endopeptidase-24.11 (EC 3.4.24.11). No hydrolysis by peptidyl dipeptidase A (angiotensin I converting enzyme, EC 3.4.15.1) was observed. The contribution of the various microvillar membrane peptidases was assessed by including specific inhibitors. Phosphoramidon, an inhibitor of endopeptidase-24.11, caused 80-100% suppression of the products. Captopril and amastatin (inhibitors of peptidyl dipeptidase A and aminopeptidases respectively) had no significant effect. Hydrolysis at an undefined site within the disulphide-linked ring occurred rapidly, followed by hydrolysis at other sites, including the Ser25--Phe26 bond. ...
Elevated plasma natriuretic peptide levels after AMI (acute myocardial infarction) are associated with adverse outcome. The aim of the present study was to examine the relationship of plasma N-ANP (N-terminal pro-atrial natriuretic peptide) and N-BNP (N-terminal pro-B-type natriuretic peptide) with mortality and heart failure following AMI. We studied 403 patients with AMI. Blood was sampled for measurement of N-ANP and N-BNP on a single occasion between 72 and 96 h after symptom onset. Natriuretic peptide levels were related to all-cause mortality and heart failure episodes. During follow up (median, 462 days; range 5-764), 43 (10.7%), 25 (6.2%) and 49 (12.2%) patients suffered death, heart failure hospitalization and outpatient heart failure respectively. Only N-BNP (P,0.0005), N-ANP (P=0.005) and previous AMI (P=0.016) were independently predictive of death. N-BNP, but not N-ANP, predicted 30-day mortality. N-ANP, but not N-BNP, predicted mortality after 30 days. N-BNP was the better ...
TY - JOUR. T1 - Atrial natriuretic polypeptide (ANP) in human ventricle increased gene expression of ANP in dilated cardiomyopathy. AU - Saito, Yoshihiko. AU - Nakao, Kazuwa. AU - Arai, Hiroshi. AU - Sugawara, Akira. AU - Morii, Narito. AU - Yamada, Takayuki. AU - Itoh, Hiroshi. AU - Shiono, Shozo. AU - Mukoyama, Masashi. AU - Obata, Kenji. AU - Yasue, Hirofumi. AU - Ohkubo, Hiroaki. AU - Nakanishi, Shigetada. AU - Imura, Hiroo. PY - 1987/10/14. Y1 - 1987/10/14. N2 - Tissue levels of atrial natriuretic polypeptide (ANP) messenger RNA (ANPmRNA) and ANP in the human atrium and ventricle were measured simultaneously by the blot hybridization technique and the specific radioimmunoassay for ANP. Hearts were obtained from two patients without cardiac complications and from a patient with dilated cardiomyopathy (DCM) at autopsy. Total RNA extracted from ventricles contained a hydridizing RNA band of the same size as atrial ANPmRNA in both control and DCM hearts. The ANPmRNA level in the control ...
Previous studies have shown that atrial natriuretic factor, a powerful vasorelaxant of precontracted vessels, inhibits the secretion of aldosterone stimulated by angiotensin II, adrenocorticotropic hormone, and potassium. We now report the presence of specific binding sites for atrial natriuretic factor in rat blood vessels (mesenteric and renal arteries) and adrenal capsules. Radioiodinated synthetic atrial natriuretic factor bound to a single class of high-affinity (KD = 0.1 nM) low-capacity receptors in a particulate fraction from blood vessels and adrenals. Unrelated peptides did not displace atrial natriuretic factor. Fragments of atrial natriuretic factor displaced the labeled ligand with decreasing potency after cleavage at the N-terminal. The cleavage of the C-terminal tyrosine did not decrease the potency of atrial natriuretic factor, but further cleavage at the C-terminal dramatically reduced the affinity of the resulting peptides. The potency of the atrial natriuretic factor fragments ...
1. The effects of the infusion of a low dose (2 pmol min−1 kg−1 for 3 h) of human atrial natriuretic peptide (hANP) were studied in seven healthy volunteers undergoing a water diuresis. Lithium clearance was used to monitor proximal tubular function.. 2. hANP increased urine flow rate, sodium, calcium and magnesium excretion without significant changes in potassium and phosphate excretion, heart rate or blood pressure.. 3. hANP caused a small change in fractional lithium clearance, and larger changes in distal nephron handling of sodium and water.. 4. Plasma renin activity tended to decrease during the infusion of hANP, while plasma aldosterone concentration decreased during and increased after stopping the infusion of hANP.. 5. The data suggest that hANP inhibits the reabsorption of sodium and water by an action on distal segments of the nephron and perhaps the proximal tubule. Inhibition of renin and aldosterone secretion may contribute to the natriuresis. ...
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human N-Terminal Pro-Atrial Natriuretic Peptide (NT-ProANP) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species ...
Plasma atrial natriuretic peptide in essential hypertension: effects of changes in dietary sodium. Sagnella, Giuseppe A.; Markandu, Nirmala D.; Buckley, Martin G.; Singer, Donald R.J.; Sugden, A. Louise; Shore, Angela C.; MacGregor, Graham A. // British Medical Journal (Clinical Research Edition);8/15/1987, Vol. 295 Issue 6595, p417 Examines the plasma atrial natriuretic peptide in essential hypertension. Effects of changes in dietary intake on plasma atrial peptides; Occurrence of change in plasma concentration of atrial peptide values during the transfer from normal to high sodium diet; Correlation between the fall in... ...
1. To study the anti-hypertensive effects of atrial natriuretic peptide (ANP), eight patients with mild to moderate essential hypertension, on no treatment, were infused with α-human ANP (102-126) (37 pmol min−1 kg−1) or placebo for 60 min and observed for a further 4 h on the fifth day of low and high sodium diets in a randomized, cross-over study.. 2. Plasma ANP levels increased over 30-fold into the high pathophysiological range during ANP infusion, but had returned to control values by 60 min after the end of infusion. With ANP infusion, there was a large decrease in supine blood pressure which was similar on both the low and high sodium intakes and was maximal 20-40 min after completion of the infusion. These reductions in blood pressure were sustained for a further 4 h after the end of ANP infusion and for 3 h after plasma ANP levels had returned to control values.. 3. Maximal urinary sodium excretion increased 10-fold on the low sodium diet (negative sodium balance 20 mmol) and ...
[Effects of female sex hormones on atrial natriuretic factor gene expression in rats].: To clarify the effects of female sex hormones on ANF gene expression, em
We investigated the hemodynamic effect of synthetic atrial natriuretic factor Auriculin A (ANF) and its influence on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits anesthetized with alpha-chloralose and urethane. The neural mechanisms underlying these effects were also studied. In the intact animal, a 45-minute constant infusion of ANF (2 micrograms/kg prime, 0.2 microgram/kg/min) significantly reduced mean blood pressure and increased mean perfusion pressure, while heart rate did not change. Comparable data were obtained with lower (0.5 microgram/kg + 0.05 microgram/kg/min; 1 microgram/kg + 0.1 microgram/kg/min) or higher (4 micrograms/kg + 0.4 microgram/kg/min; 8 micrograms/kg + 0.8 microgram/kg/min) doses of ANF. In addition, ANF enhanced bradycardic reflex responses to phenylephrine i.v. bolus administration, while it did not change baroreflex-mediated responses to nitroglycerin i.v. bolus ...
Definition of atrial natriuretic factor in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is atrial natriuretic factor? Meaning of atrial natriuretic factor as a finance term. What does atrial natriuretic factor mean in finance?
To explore whether pathophysiological plasma levels of atrial natriuretic peptide (ANP) actually involve sodium excretion in spontaneously hypertensive rats (SHR), we examined the in vivo and ex vivo effects of ANP and an endopeptidase inhibitor, thiorphan, on urinary sodium excretion and the elimination rate of ANP. We found the following: 1) The basal plasma ANP level was higher in 16-week-old SHR than in Wistar-Kyoto (WKY) rats (109 +/- 10 [SEM] versus 63 +/- 4 pg/ml, p less than 0.001). Thiorphan (30 mg/kg i.v.) significantly increased plasma ANP by 60% in both SHR and WKY rats. However, increases in urinary sodium excretion (+290% versus +130%, p less than 0.05) and cyclic GMP (+160% versus +60%, p less than 0.05) were greater in SHR than in WKY rats. Urinary excretion of ANP was markedly increased by thiorphan, and its increase was greater in SHR than in WKY rats. 2) The thiorphan-induced natriuresis was substantially attenuated by antiserum for ANP but not by a bradykinin receptor ...
Renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury and a frequent occurrence in critically ill patients. Renal IRI releases proinflammatory cytokines within the kidney that induce crosstalk between the kidney and other organ systems. Atrial natriuretic peptide (ANP) has anti-inflammatory as well as natriuretic effects and serves important functions as a regulator of blood pressure, fluid homeostasis, and inflammation. The objective of the present study was to elucidate whether ANP post-treatment attenuates kidney-lung-heart crosstalk in a rat model of renal IRI. In experiment I, a rat model of unilateral renal IRI with mechanical ventilation was prepared by clamping the left renal pedicle for 30 min. Five minutes after clamping, saline or ANP (0.2 μg/kg/min) was infused. The hemodynamics, arterial blood gases, and plasma concentrations of lactate and potassium were measured at baseline and at 1, 2, and 3 h after declamping. The mRNA expression and localization of tumor
METHODS AND RESULTS Twenty patients with acute right ventricular infarction were examined who underwent reperfusion therapy on admission. These patients had proximal occlusion of the dominant right coronary artery involving the right atrial branches: 9 patients with successful reperfusion (SRP group) and the remaining 11 patients with unsuccessful reperfusion (URP group). Within 24 hours after the onset of infarction, a volume loading test was performed after reperfusion therapy with measurements for plasma ANP levels and hemodynamics. Before the volume loading test, the plasma ANP level and mean right atrial pressure were similar between these two groups. However, in the URP group, percent increase in ANP in response to volume loading was strikingly smaller (URP, 45 +/- 18% versus SRP, 133 +/- 25%; P , .01) despite similar percent increase in mean right atrial pressure (URP, 100 +/- 46% versus SRP, 86 +/- 23%). The peak ANP level occurred significantly later in the URP group (69 +/- 16 hours) ...
In response to a high salt intake, salt-sensitive hypertensive individuals retain more sodium and manifest a rise in blood pressure greater than that in salt-resistant individuals. In this study, we tested whether salt sensitivity might be related at least in part to reduced secretion of atrial natriuretic peptide (ANP) or to abnormal nitric oxide production. We measured plasma ANP and NO2+NO3 in 7 normotensive individuals and 13 salt- sensitive and 14 salt-resistant blacks with essential hypertension under conditions of low (10 mEq/d) and high (250 mEq/d) salt intake. To evaluate possible racial differences in ANP secretion, we also measured plasma ANP in 6 salt-sensitive and 8 salt-resistant hypertensive whites during low and high salt intakes. Under low salt conditions, plasma ANP levels were not different in normotensive control subjects and salt-sensitive and salt-resistant hypertensive blacks. During high salt intake, plasma ANP levels did not change in control subjects and salt-resistant ...
A 75-year-old Japanese man was hospitalized for hypokalemia. Levels of plasma adrenocorticotropic hormone (ACTH) and free cortisol in urine were elevated to 220 pg/mL (normal, 9 to 52 pg/mL) and 793 mg/d (normal, 30 to 100 mg/d), respectively. Blood concentration of corticotropin-releasing factor was 13.8 pg/mL (normal, ,40 pg/mL). Chest radiographs and computed tomographic examinations showed an enlarged thymic gland and normal-sized adrenal glands. Venous samplings in the superior and inferior vena cava at several levels showed markedly increased plasma atrial natriuretic peptide concentrations near the thymic tumor (from 120 to 620 pg/mL). By contrast, plasma ACTH concentrations were constant at all sites sampled. Pathologic study results were compatible with carcinoid. Immunohistochemical staining for atrial natriuretic peptides and ACTH in the dissected tumor tissue showed several cells to be positively stained for the peptides. No ACTH-containing cells were detected. After the tumor was ...
TY - JOUR. T1 - Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension. AU - Campese, Vito M.. AU - Tawadrous, Medhat. AU - Bigazzi, Roberto. AU - Bianchi, Stefano. AU - Mann, Amardeep S.. AU - Oparil, Suzanne. AU - Raij, Leopoldo. PY - 1996/9. Y1 - 1996/9. N2 - In response to a high salt intake, salt-sensitive hypertensive individuals retain more sodium and manifest a rise in blood pressure greater than that in salt-resistant individuals. In this study, we tested whether salt sensitivity might be related at least in part to reduced secretion of atrial natriuretic peptide (ANP) or to abnormal nitric oxide production. We measured plasma ANP and NO2+NO3 in 7 normotensive individuals and 13 salt- sensitive and 14 salt-resistant blacks with essential hypertension under conditions of low (10 mEq/d) and high (250 mEq/d) salt intake. To evaluate possible racial differences in ANP secretion, we also measured plasma ANP in 6 salt-sensitive and 8 salt-resistant hypertensive ...
TY - JOUR. T1 - Exertional Changes in Circulating Cardiac Natriuretic Peptides in Patients with Suggested Coronary Artery Disease. AU - Bergeron, Sébastien. AU - Møller, Jacob E.. AU - Bailey, Kent R.. AU - Chen, Horng H.. AU - Burnett, John C.. AU - Pellikka, Patricia A.. PY - 2006/6/1. Y1 - 2006/6/1. N2 - Background: We measured plasma brain natriuretic peptide (BNP) and N-terminal atrial natriuretic peptide (ANP) levels before and after exercise stress testing and correlated results with echocardiographic evidence of ischemia. Methods: Sixty patients with left ventricular ejection fraction greater than 50% referred for clinically indicated exercise echocardiogram were studied. Peptides were measured at rest and 5 minutes after symptom-limited exercise. Results: Echocardiography was positive for ischemia in 19 (32%). With exercise, ANP level increased in all 60 patients (median at rest 2501 [799-6440]-3167 [977-8563] pg/mL after exercise [P , .0001]). BNP increased in 54 patients (90%) (19 ...
TY - JOUR. T1 - Atrial natriuretic peptide in hypothyroidism. AU - Zimmerman, R. S.. AU - Gharib, H.. AU - Zimmerman, D.. AU - Heublein, D.. AU - Burnett, J. C.. PY - 1987/2. Y1 - 1987/2. N2 - The effect of hypothyroidism on circulating levels of atrial natriuretic peptide (ANP) was studied in 11 hypothyroid patients (aged 11-65 yr; mean, 31 yr) and 13 normal subjects (aged 28-39 yr; mean, 32 yr). Plasma ANP was 32 ± 9 (±sd) pg/ml in normal subjects and 20 ± 5 pg/ml in the hypothyroid patients (P , 0.005). In 7 hypothyroid patients, plasma ANP levels were measured after 10-14 weeks of l-T4 therapy. ANP increased from 22 ± 5 to 46 ± 18 pg/ml (P , 0.02), along with an increase in mean serum T4 from 0.6 ± 0.5 to 8.1 ± 2.5 μg/dl (P , 0.001). Thus, hypothyroidism is characterized by decreased circulating levels of ANP which are reversed by l-T4 therapy.. AB - The effect of hypothyroidism on circulating levels of atrial natriuretic peptide (ANP) was studied in 11 hypothyroid patients (aged ...
The aim of the present study was to determine whether left atrial size--a likely indicator of atrial stretching--correlates with the plasma concentration of atrial natriuretic peptide and whether this relation is different in patients in sinus rhythm and in those with atrial fibrillation. Arterial plasma concentrations of immunoreactive atrial natriuretic peptide (ir-ANP), adrenaline, noradrenaline, aldosterone, and vasopressin were measured in 13 patients in sinus rhythm without apparent heart failure and in 13 patients in atrial fibrillation. The two groups were matched for left atrial diameter and the ratio of the left atrial diameter to the diameter of the aortic root (assessed by echocardiography). There were no significant differences in age, heart rate, blood pressure, or left ventricular end diastolic diameter between the two groups. Left atrial diameters varied from 33 to 60 mm. The mean (SD) plasma concentration of ir-ANP was significantly higher (35 (21) pmol/l) in the patients with ...
SWISS-MODEL Template Library (SMTL) entry for 7brj.1. Atrial Natriuretic Peptide Receptor complexed with deletion mutant of human Atrial Natriuretic Peptide[7-28]
The influence of physiological cardiac hypertrophy on the concentration of plasma atrial natriuretic peptide was studied in six male athletes and six normally active, matched control men. They were examined by echocardiography during a graded exercise test on a bicycle ergometer. Plasma atrial natriuretic peptide was measured at rest, at each workload until exhaustion, and 15 and 30 minutes after the exercise test. Echocardiography showed that the athletes had a significantly larger left atrium, left ventricular end diastolic diameter, left ventricular posterior wall, interventricular septum, left ventricular ejection fraction, and left ventricular mass than the controls. The athletes performed significantly more work than the control group--325 W v 277 W. The plasma concentration of atrial natriuretic peptide rose by a mean factor of 2.76 (range 1.78-4.28) in all men from rest to maximum exercise. There were no differences between the athletes and the controls in the concentrations of plasma ...
Synonyms for Atrial natriuretic peptide in Free Thesaurus. Antonyms for Atrial natriuretic peptide. 4 words related to peptide: amide, fibrinopeptide, polypeptide, endorphin. What are synonyms for Atrial natriuretic peptide?
The effects of acute volume expansion and acute salt loading on the plasma levels of immunoreactive atrial natriuretic peptides (ir-ANPs) were investigated in conscious adult (16 weeks) Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Basal plasma concentrations of ir-ANPs were similar (108 +/- 9 pg/ml and 105 +/- 8 pg/ml, respectively) in hypertensive and normotensive rats. In both strains mean arterial pressure, heart rate and plasma catecholamines were unaltered by acute volume expansion but significantly elevated by acute salt loading. However, both acute volume expansion and acute salt loading increased plasma concentrations of ir-ANPs similarily in SHR and WKY rats, independent of blood pressure or plasma catecholamine levels. Our findings show that chronic hypertension in SHR does not result in changes in basal or VOL- and SAL-stimulated levels of circulating ir-ANPs.
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திறன்மிகு நாள விரிப்பியான (Vasodilator) இதயியச் சோடியச்சிறுநீர்மைப் புரதக்கூறு [Atrial natriuretic peptide; (ANP), atrial natriuretic factor; (ANF), atrial natriuretic hormone; (ANH), Cardionatrine, Cardiodilatine; (CDD), atriopeptin], இதயத்தசைச் செல்களால் சுரக்கப்படும் புரதக்கூற்று இயக்குநீராகும்[2][3][4]. இப்புரதக்கூறானது உடலின் நீர், சோடியம், பொட்டாசியம், கொழுப்புத் திசுக்களில் உள்ள கொழுப்பு ஆகியவற்றின் சமநிலையைக் கட்டுபடுத்துவதில் ஈடுபட்டுள்ளது; இரத்தத்தின் கன அளவு ...
The clinical significance of cardiac Natriuretic Peptides (cNP) plasma levels has been shown to differ in obese and non-obese subjects. Recent lines of evidence suggest important metabolic effects of the cNP system, which has been shown to activate lipolysis, enhance lipid oxidation and mitochondrial respiration. Clinically, these properties lead to browning of white adipose tissue and to increased muscular oxidative capacity. In patients without heart disease higher cNP concentrations were observed in lean, insulin-sensitive subjects, while obese and type-2 diabetics may display reduced cNP levels.
Occurrence of a novel cardiac natriuretic peptide in rats.: We established a specific radioimmunoassay for the ring structure of iso-ANP and detected iso-ANP[
TY - JOUR. T1 - Atrial natriuretic factor modulates whole kidney tubuloglomerular feedback. AU - Margulies, K. B.. AU - Burnett, John C Jr.. PY - 1990. Y1 - 1990. N2 - Increases in sodium delivery to the distal nephron reduce glomerular filtration rate (GFR) via tubuloglomerular feedback (TGF). Central volume expansion and pharmacological concentrations of atrial natriuretic factor (ANF) are known to attenuate this response. To test the hypothesis that whole kidney TGF is attenuated by pathophysiological concentrations of ANF, hypertonic saline was given intrarenally in five dogs receiving an intravenous infusion of synthetic ANF at 20 ng·kg-1·min-1. To examine whole kidney TGF responses in heart failure, six additional dogs with acute congestive heart failure induced by rapid ventricular pacing also received intrarenal hypertonic saline. Seven sham-paced dogs served as controls. An isolated increase in circulating ANF from 26 ± 3 to 342 ± 23 pg/ml abolished the whole kidney GFR response to ...
BACKGROUND: Natriuretic peptides are currently used in the diagnosis and follow-up of patients with Chronic Heart Failure (CHF). However, it is unknown whether there are different influences of age on atrial natriuretic peptide (ANP)/N-terminal-ANP (NT-ANP) or B-type natriuretic peptide (BNP)/N-terminal-proBNP (NT-proBNP). AIMS: To compare the influence of age and gender on plasma levels of ANP/NT-ANP and BNP/NT-proBNP in CHF patients. METHODS AND RESULTS: Natriuretic peptides were measured in 311 CHF patients (68+/-8 years, 76% males, left ventricular ejection fraction (LVEF) 0.23+/-0.08). All natriuretic peptides were significantly related to age (p,0.05) on multivariate regression analysis, with partial correlation coefficients of 0.18, 0.29, 0.28 and 0.25 for ANP, NT-ANP, BNP and NT-proBNP, respectively. The relative increase of both BNP/NT-proBNP were more pronounced than of ANP/NT-ANP (p,0.01). Furthermore, the relative increase of BNP with age was markedly larger than of NT-proBNP ...
The role of atrial natriuretic factor (ANF) in modulating volume and circulatory homeostasis remains uncertain, and there has been as yet no systematic analysis of the factors promoting ANF release in humans. Since immersion in water to the neck provides a volume stimulus identical to that induced by 2 litres of saline, without plasma compositional change, immersion to the neck was used to assess the ANF response to acute central blood-volume expansion. Using a radio-immunoassay that reliably detected ANF in human plasma extracts, more than 80% of plasma immunoreactive (ir) ANF was shown to elute as a single peak on reverse-phase high performance liquid chromatography, with a retention time identical to that of the synthetic 28-residue alpha-human (alpha-h) ANF. The response of plasma irANF to 3 h of immersion in water to the neck was evaluated in four sodium-replete normal subjects; the immersion produced a prompt and marked increase in irANF in each subject, and recovery was associated with a prompt
BACKGROUND--Plasma levels of atrial natriuretic peptide (ANP) are elevated in patients with chronic obstructive pulmonary disease (COPD) and may have a role in preventing oedema formation in these patients. METHODS--Plasma ANP levels were measured in 60 patients with COPD and these measurements were related to pulmonary haemodynamics, response to treatment during exacerbations, and clinical patterns of the stable disease. RESULTS--Plasma ANP levels did not correlate significantly with right atrial or pulmonary arterial pressures but did correlate significantly with both the right ventricular end diastolic volume and right ventricular wall volume measured by magnetic resonance imaging. Oxygen (2 1/min by nasal prongs for 30 minutes) did not change the mean pulmonary arterial pressure or the level of plasma ANP. In 20 patients with an acute exacerbation of COPD plasma ANP levels were higher in those with oedema (302 (185) pg/ml) than in those without oedema (87 (43) pg/ml). Oxygen given for one ...
Title:The Emerging Role of Atrial Natriuretic Peptide in Psychiatry. VOLUME: 28 ISSUE: 1. Author(s):Donatella Marazziti, Filippo Maria Barberi, Federico Mucci*, Alessandra Maglio, Valerio DellOste and Liliana DellOsso. Affiliation:Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Pisa. Keywords:Atrial natriuretic peptide, depression, anxiety disorder, post-traumatic stress disorder, schizophrenia, alcohol abuse, ANP.. Abstract:Introduction: Atrial natriuretic peptide ...
TY - JOUR. T1 - Physiological features of edematous dogs unresponsive to atrial natriuretic peptide. AU - Maher, Elizabeth. AU - Cernacek, Peter. AU - Levy, Mortimer. PY - 1990. Y1 - 1990. N2 - Sodium-retaining cirrhotic and chronic caval dogs with ascites show a heterogeneous natriuretic response to atrial natriuretic factor (ANF) infusions such that half will increase their urinary excretion of sodium and half will show no natriuretic response whatsoever. In these studies we have examined several physiological variables that might discriminate between these two experimental populations. We studied 22 caval dogs (11 natriuretic responders, 11 nonresponders) and 19 cirrhotic dogs (9 responders, 10 nonresponders). After an infusion of rat ANP-(1-28), 125 ng·kg-1·min-1, differences in glomerular filtration rate, blood pressure, or urinary excretion of guanosine 3,5-cyclic monophosphate (cGMP) could not differentiate between the two types of dogs. When the left kidney of nonresponding dogs in ...
The physiological actions of the atrial peptide system are discussed in relation to its potential role in the aetiology and treatment of hypertension and congestive heart failure (CHF). Atrial natriuretic factor (ANF) exerts marked natriuretic, diure
To evaluate the role of calcium in volume-induced secretion of atrial natriuretic factor (ANF), effects of verapamil and endothelin-1 (ET-1), both known to influence free intracellular calcium, were studied during saline infusion in seven conscious instrumented dogs. Fifteen minutes after intravenous injection of placebo or verapamil (0.25 mg/kg) or during continuous ET-1 infusion (at 5 ng.kg-1.min-1), saline (10% body wt) was infused during 40 min. Saline produced a rise (P less than 0.001) of plasma ANF from 28.1 +/- 6.3 to 50.4 +/- 12.9 pM after placebo, from 30.2 +/- 6.1 to 51.1 +/- 8.5 pM after verapamil, and from 31.2 +/- 6.1 to 81.0 +/- 12.9 pM with ET-1. This increase was comparable after placebo and verapamil, but was 80% greater with ET-1 (P less than 0.02). Plasma ET-1, unchanged after placebo, rose (P less than 0.001) from 1.7 +/- 0.5 to 38.3 +/- 9.2 pM with ET-1. In the three experiments, heart rate and left atrial pressure (LAP) increased (P less than 0.001) similarly. The linear ...
Learn in-depth information on Atrial Natriuretic Peptide Blood Test, on why the laboratory test is performed, specimen collected, the significance of the results, and its use in diagnosing medical conditions.
N2 - *Atrial natriuretic factor (ANP) has shown over recent decades to play an emerging role in the regulation of coronary blood flow as well as systemic blood pressure. The common polymorphism in the atrial natriuretic peptide precursor gene (NPPA), +2238 T/C, was in the previous studies associated with hypertension as well as other cardiovascular conditions. The purpose of the study was to identify the possible relationship between the +2238 T/C polymorphism and restenosis in coronary arteries stented due to the coronary artery disease (CAD ...
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BACKGROUND: The natriuretic peptides are counterregulatory hormones involved in volume homeostasis and cardiovascular remodeling. The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established.. METHODS: We prospectively studied 3346 persons without heart failure. Using proportional-hazards regression, we examined the relations of plasma B-type natriuretic peptide and N-terminal pro-atrial natriuretic peptide to the risk of death from any cause, a first major cardiovascular event, heart failure, atrial fibrillation, stroke or transient ischemic attack, and coronary heart disease.. RESULTS: During a mean follow-up of 5.2 years, 119 participants died and 79 had a first cardiovascular event. After adjustment for cardiovascular risk factors, each increment of 1 SD in log B-type natriuretic peptide levels was associated with a 27 percent increase in the risk of death (P=0.009), a 28 percent increase in the risk of a first cardiovascular ...
TY - JOUR. T1 - Comparative effects of atrial natriuretic peptide and brain natriuretic peptide on the aldosterone and pressor responses to angiotensin II in man. AU - Cargill, Robert I.. AU - Struthers, Allan D.. AU - Lipworth, Brian J.. PY - 1995. Y1 - 1995. N2 - 1. Atrial natriuretic peptide and brain natriuretic peptide have similar vasodilator and natriuretic properties, although little information is available regarding their relative effects as antagonists of the renin-angiotensin-aldosterone system. We have therefore compared how atrial natriuretic peptide and brain natriuretic peptide affect the systemic pressor and aldosterone responses to angiotensin II in eight male subjects. 2. Each subject was studied on three separate occasions, when they received a 60-min infusion of placebo, atrial natriuretic peptide (10 pmol min-1 kg-1) or brain natriuretic peptide (10 pmol min-1 kg-1), with a concomitant infusion of angiotensin II (6 ng min-1 kg-1) given for the final 30 min of the infusion ...
TY - JOUR. T1 - Atrial natriuretic factor inhibits Na-K-Cl cotransport in teleost intestine. AU - OGrady, S. M.. AU - Field, M.. AU - Nash, N. T.. AU - Rao, M. C.. PY - 1985/1/1. Y1 - 1985/1/1. N2 - Addition of atrial natriuretic factor (ANF) to the contraluminal side of the intestinal mucosa of a marine teleost, the winter flounder Pseudopleuronectes americanus, inhibits short-circuit current, net transepithelial fluxes of Na and Cl, and the unidirectional influx of Rb across the brush border membrane. This action of ANF is closely mimicked by addition of 8-bromo-guanosine 3,5-cyclic monophosphate (8-BrcGMP). In contrast to the intestine, the opercular epithelium of the flounder did not respond to the in vitro addition of either ANF or 8-BrcGMP. Because intestinal salt and water absorption diminishes when marine fish enter water of lower salinity, ANF may be an important hormonal regulator through which euryhaline fish adapt to varying salinities.. AB - Addition of atrial natriuretic factor ...
Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene. The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP). Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control. Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA). GRCh38: Ensembl release 89: ENSG00000163273 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000026241 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Entrez Gene: ...
TY - JOUR. T1 - Hemodynamic and renal excretory effects of human brain natriuretic peptide infusion in patients with congestive heart failure. T2 - A double-blind, placebo-controlled, randomized crossover trial. AU - Marcus, Lee S.. AU - Hart, Douglas. AU - Packer, Milton. AU - Yushak, Madeline. AU - Medina, Norma. AU - Danziger, Robert S.. AU - Heitjan, Daniel F.. AU - Katz, Stuart D.. PY - 1996. Y1 - 1996. N2 - Background: The pharmacological effects of infusion of human brain natriuretic peptide (hBNP) in patients with severe congestive heart failure have not been characterized previously. Methods and Results: Twenty patients with severe congestive heart failure were randomized in a double-blind, placebo-controlled, crossover trial to receive incremental 90-minute infusions of hBMP (0.003, 0.01, 0.03, and 0.1 μg/kg per minute) or placebo on 2 consecutive days. At the highest completed dose of the hBNP, mean pulmonary artery pressure decreased from 38.3±1.6 to 25.9±1.7 mm Hg; mean pulmonary ...
Frossard et al. (1997) studied an insertion/deletion (I/D) dimorphism located in the second intron of the human atrial natriuretic factor (ANF) gene among 232 UAE nationals (112 normotensives and 120 hypertensives) from the Abu Dhabi Emirate, with a view to evaluating the value of this marker in relation to hypertension. Results reveal that genotype frequencies of this I/D marker occur in Hardy-Weinberg proportions (respective genotype frequencies in the overall sample population are: II, 51%; ID, 42%; DD, 7%). No association, however, was evidenced between this dimorphic site and clinical diagnosis of essential hypertension. This suggests that: 1) this I/D dimorphism is not a useful marker to study the relationship between the ANF gene and hypertension in the UAE; and 2) variations of the ANF gene that may be in linkage disequilibrium with this marker do not play a major role in the determination of hypertension in this Arab population. Obineche et al. (2002) carried out a case-controlled study ...
TY - JOUR. T1 - C-type natriuretic peptide/guanylate cyclase B system in ATDC5 cells, a chondrogenic cell line. AU - Suda, Michio. AU - Tanaka, Kiyoshi. AU - Yasoda, Akihiro. AU - Komatsu, Yasato. AU - Chusho, Hideki. AU - Miura, Masako. AU - Tamura, Naohisa. AU - Ogawa, Yoshihiro. AU - Nakao, Kazuwa. PY - 2002/12/1. Y1 - 2002/12/1. N2 - Natriuretic peptides constitute a family of three structurally related peptides: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Particulate guanylate cyclases, GC-A, and GC-B, are the receptors for these peptides to mediate their action. ANP and BNP possess high affinities for GC-A, and CNP is the preferred ligand for GC-B. In this article, we report our study of the expression and possible role(s) of natriuretic peptides in ATDC5 cells, which represent a chondrogenic cell line. ATDC5 cells produced cyclic guanosine monophosphate (cGMP) in response to natriuretic peptides. CNP was far more potent than ANP ...
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
The measurement of natriuretic peptides for the diagnosis of heart failure has been a major breakthrough in cardiology (1)(2). B-Type natriuretic peptide (BNP) is synthesized as preproBNP mainly in the ventricular myocardium. On ventricular myocyte stretch, preproBNP is enzymatically cleaved to proBNP and released in the form of the hormonally active BNP and the inactive N-terminal proBNP (NT-proBNP). Both BNP and NT-proBNP have been shown to reflect heart failure severity (1), but studies on their sensitivity and specificity for different degrees of heart failure produced conflicting results (3)(4)(5)(6). Both BNP and NT-proBNP can be used for the diagnosis of heart failure, but there are important differences between the two tests, particularly regarding influence of age and renal function (1). In addition to glomerular filtration, BNP is eliminated from plasma mainly through natriuretic peptide receptors and degraded by neutral endopeptidases (7)(8)(9). In contrast, NT-proBNP possibly is ...
TY - JOUR. T1 - Rat brain natriuretic peptide. T2 - Isolation from rat heart and tissue distribution. AU - Nakao, Kazuwa. AU - Itoh, Hiroshi. AU - Kambayashi, Yoshikazu. AU - Hosoda, Kiminori. AU - Saito, Yoshihiko. AU - Yamada, Takayuki. AU - Mukoyama, Masashi. AU - Arai, Hiroshi. AU - Shirakami, Gotaro. AU - Suga, Shin Ichi. AU - Jougasaki, Michihisa. AU - Ogawa, Yoshihiro. AU - Inouye, Ken. AU - Imura, Hiroo. PY - 1990/6. Y1 - 1990/6. N2 - We have isolated a cardiac natriuretic peptide of 5, 000 d from atrial tissues from 500 rats and determined its amino acid sequence. The 5, 000 d atrial natriuretic factor was elucidated to be a 45 amino acid peptide with the sequence of S-Q-D-S-A-F-R-I-Q-K-R-L-R-N-S-K-M-A-H-S-S-S-C-F-G-Q-K-I-D-R-I-G-A-V-S-R-L-G-C-D-G-L-R-L-F by sequencing the native peptide and its lysyl endopeptidase digests. The sequence of this peptide was identical to the amino acid sequence (51-95) of the rat brain natriuretic peptide precursor deduced from the complementary DNA ...
Brain natriuretic peptide (BNP) was originally identified in extracts of porcine brain. However, in humans, it is produced mainly in the cardiac ventricles in response to excessive stretching of heart muscle cells (cardiomyocytes); high concentrations of BNP in the blood are a marker of heart failure. BNP is also known as natriuretic peptide B, gamma-brain natriuretic peptide, and GC-B. The release of BNP is controlled by calcium ions. BNP binds to and activates the atrial natriuretic factor receptors NPRA and NPRB, similar to atrial natriuretic peptide (ANP) but with much lower affinity. Both BNP and ANP cause a net decrease in blood volume, which lowers the bodys blood pressure. Recombinant BNP is used to treat decompensated heart failure.. ...
Brain natriuretic peptide (BNP) was originally identified in extracts of porcine brain. However, in humans, it is produced mainly in the cardiac ventricles in response to excessive stretching of heart muscle cells (cardiomyocytes); high concentrations of BNP in the blood are a marker of heart failure. BNP is also known as natriuretic peptide B, gamma-brain natriuretic peptide, and GC-B. The release of BNP is controlled by calcium ions. BNP binds to and activates the atrial natriuretic factor receptors NPRA and NPRB, similar to atrial natriuretic peptide (ANP) but with much lower affinity. Both BNP and ANP cause a net decrease in blood volume, which lowers the bodys blood pressure. Recombinant BNP is used to treat decompensated heart failure.. ...
BACKGROUND: In mammalian follicles, oocytes are arrested at the diplotene stage of prophase I until meiotic resumption following the LH surge. Recently, C-type natriuretic peptide (CNP), encoded by natriuretic peptide precursor type C (NPPC) was found to suppress mouse oocyte maturation by promoting cyclic guanosine 5-monophospate (cGMP) production in cumulus cells. However, regulation of NPPC/CNP expression during the pre-ovulatory period and their regulation by the LH surge have not been investigated.. METHODS AND RESULTS: Based on genome-wide analysis of DNA microarray data sets using samples from periovulatory ovaries, we found increases in NPPC transcripts in granulosa cells during pre-ovulatory follicle growth in mice and a rapid decline induced by the pre-ovulatory LH/hCG stimulation. Treatment of pre-ovulatory animals with hCG decreased ovarian CNP content. In isolated ovarian cells, NPPC mRNA was predominantly expressed in mural granulosa cells exhibiting similar regulation following ...
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Brain natriuretic peptide (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume. BNP is named as such because it was originally identified in extracts of pig brain. The 32-amino acid polypeptide BNP is secreted attached to a 76-amino acid N-terminal fragment in the prohormone called NT-proBNP (BNPT), which is biologically inactive. Once released, BNP binds to and activates the atrial natriuretic factor receptor NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better targets than ANP for diagnostic blood testing. The physiologic actions of BNP are similar to those of ANP and include decrease in systemic vascular resistance and central venous pressure as well as ...
TY - JOUR. T1 - Atrial natriuretic peptide inhibits angiotensin II-stimulated proliferation in fetal cardiomyocytes. AU - OTierney, P. F.. AU - Chattergoon, N. N.. AU - Louey, S.. AU - Giraud, G. D.. AU - Thornburg, K. L.. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2010/8. Y1 - 2010/8. N2 - The role of atrial natriuretic peptide (ANP) in regulating fetal cardiac growth is poorly understood. Angiotensin II (Ang II) stimulates proliferation in fetal sheep cardiomyocytes when growth is dependent on the activity of the mitogen-activated protein kinase (MAPK) and phosphoinositol-3-kinase (PI3K) pathways. We hypothesized that ANP would suppress near-term fetal cardiomyocyte proliferation in vitro and inhibit both the MAPK and PI3K pathways. Forty-eight hour 5-bromodeoxyuridine (BrdU) uptake (used as an index of proliferation) was measured in cardiomyocytes isolated from fetal sheep (135 day gestational age) in response to 100 nmAng IIwith orwithoutANP(0.003-100 nm) or 1 ...
Results: ET-1 levels were significantly higher in primary hypertension (9.93 ± 1.73 pg/ml) and renal hypertension (10.77 ± 1.50 pg/ml) in comparison to controls (4.03 ± 0.97 pg/ml), (p , 0.001, p , 0.001, respectively). NT-pro ANP concentrations in primary hypertension (71.03 ± 10.02 pg/ml), and renal hypertension (84.78 ± 6.44 pg/ml) were significantly higher than in the control group (29.62 ± 5.56 pg/ml) (p , 0.001, p , 0.001, respectively). TNF-α concentrations in primary hypertension (8.36 ± 1.60 pg/ml) and renal hypertension (7.35 ± 0.93 pg/ml) significantly exceeded concentrations in controls (4.49 ± 0.93 pg/ml), (p , 0.001, p , 0.001, respectively). ET-1 and NT-pro ANP concentrations in renal hypertension significantly exceeded those in primary hypertension (p = 0.049, p , 0.001, respectively) while TNF-α levels in renal hypertension were significantly lower than in primary hypertension (p = 0.046 ...
Natriuretic Peptides: Peptides that regulate the WATER-ELECTROLYTE BALANCE in the body, also known as natriuretic peptide hormones. Several have been sequenced (ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; C-TYPE NATRIURETIC PEPTIDE).
Hypoxic-ischaemic brain injury at birth is associated with 1-3/1000 cases of moderate to severe encephalopathy. Previously, we have shown that connexin 43 hemichannel blockade, with a specific mimetic peptide, reduced the occurrence of seizures, improved recovery of EEG power and sleep state cycling, and improved cell survival following global cerebral ischaemia. In the present study, we examined the dose response for intracerebroventricular mimetic peptide infusion (50 µmol/kg/h for 1 h, followed by 50 µmol/kg/24 h (low dose) or 50 µmol/kg/h for 25 h (high dose) or vehicle only (control group), starting 90 min after the end of ischaemia), following global cerebral ischaemia, induced by 30 min bilateral carotid artery occlusion, in near-term fetal sheep (128 ± 1 days gestation). Both peptide infusion groups were associated with a transient significant increase in EEG power between 2-12 h after ischaemia. The ischaemia-low dose group showed a significant recovery of EEG power from day five compared
Previous studies have shown that natriuretic peptide levels correlate inversely with GFR in chronic kidney disease (16,17). Investigators have postulated that higher filling pressures and wall stress play an important role in this cardiorenal link. However, in our patients with renal failure (75% acute), natriuretic peptide levels were massively elevated and could not be explained on the basis of higher filling pressures, wall stress, or depressed cardiac function. Moreover, natriuretic peptide levels ,1,000 pg/ml (BNP) and 10,000 pg/ml (NT-proBNP) were more specific for a GFR ,60 (BNP, 92%; NT-proBNP, 100%) than for a PCWP ,18 mm Hg (BNP, 42%; NT-proBNP, 60%).. To our knowledge, this study is the first to document such natriuretic peptide-hemodynamic dissociations in the setting of renal failure and suggests that renal function has a more direct effect on circulating natriuretic peptide levels than previously recognized. Moreover, the present study highlights the important limitations of these ...
Background Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor. Objective To investigate breed variation in plasma concentrations of pro-atrial natriuretic peptide 31-67 (proANP 31-67) and N-terminal B-type natriuretic peptide (NT-proBNP) in healthy dogs. Animals 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project. Methods Absence of cardiovascular disease or other clinically relevant organ-related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31-67 and NT-proBNP were measured by commercially available ELISA assays. Results Overall significant breed differences were found in proANP 31-67 (P,.0001) and NT-proBNP (P,.0001) concentrations. Pair-wise comparisons between breeds ...
Cardiac atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) modulate blood pressure and volume by activation of the receptor guanylyl cyclase-A (GC-A) and subsequent intracellular cGMP formation. Here we report what we believe to be a novel function of these peptides as paracrine regulators of vascular regeneration. In mice with systemic deletion of the GC-A gene, vascular regeneration in response to critical hind limb ischemia was severely impaired. Similar attenuation of ischemic angiogenesis was observed in mice with conditional, endothelial cell-restricted GC-A deletion (here termed EC GC-A KO mice). In contrast, smooth muscle cell-restricted GC-A ablation did not affect ischemic neovascularization. Immunohistochemistry and RT-PCR revealed BNP expression in activated satellite cells within the ischemic muscle, suggesting that local BNP elicits protective endothelial effects. Since within the heart, BNP is mainly induced in cardiomyocytes by mechanical load, we investigated ...
We have shown by Boydens chamber method that FCS and PDGF-BB potently stimulate the migration of SMCs. It appears reasonable that FCS induces SMC migration, since blood serum contains numerous growth and migration factors for vascular cells.29 30 Among these factors in serum, PDGF is known to have important roles in the development of atherosclerosis not only as a mitogen but also as a chemoattractant.2 We have confirmed the previous reports3 31 that PDGF-BB, as well as FCS, potently stimulates the migration of SMCs.. Second, we have shown that the natriuretic peptide family, especially CNP, inhibits the migration of SMCs stimulated with FCS and PDGF-BB in a concentration-dependent manner. In addition, when PDGF-BB-induced migration was separated into chemotactic and chemokinetic activities,32 natriuretic peptides strongly suppressed the chemotactic effect of PDGF-BB and modestly suppressed the chemokinetic effect of PDGF-BB. The suppression of the chemotactic effect of PDGF-BB by CNP-22 was ...
Because the thymus expresses the natriuretic peptides (NP) as well as their respective receptors, an involvement of NP in the physiology of this organ has been suggested. To evaluate functional aspects of NP in the thymus, we looked for thymic cells bearing NP receptors (Npr). Furthermore, the regulation of Npr expression by activation of cells and the influence of NP on the proliferation of thymocytes was studied. Expression of receptor messenger RNAs CmRNAs) was examined by PCR and Northern blot. Existence of functional Npr was confirmed by measurement of cGMP, the second messenger of NP. Proliferation of thymocytes upon concanavalin A (Con A) stimulation was analyzed by incorporation of [Hlthymidine. We report here that thymocytes express mRNAs for the three Npr, namely Npra, Nprb, and Nprc and that activation of Npra and Nprb increases cGMP levels. Stimulation of thymocytes with Con A (1 pg/ml, 48 h) resulted in an increase of mRNA coding for Npra, the receptor specific for atria1 ...
Medical term atrial natriuretic factor (ANF) 心房钠尿因子; 心房利尿钠因子 and its variants in English, Simplified Chinese, Traditional Chinese and Pinyin with audio pronunciation. 规范医学术语词汇
Atrial natriuretic peptides (ANP) have recently been identified in both heart and CNS. These peptides possess potent natriuretic, diuretic, and vasorelaxant activities, and are all apparently derived from a single prohormone. Specific ANP binding sites have been characterized in the adrenal zona glomerulosa and kidney cortex, and one study reported ANP binding sites in the CNS. However, a detailed examination of the localization of ANP binding sites throughout the brain has not been reported. In this study, quantitative autoradiography was employed to examine the distribution of ANP receptors in the rat CNS. The binding of (3-125I-iodotyrosyl28) rat ANP-28 to binding sites in the rat CNS was saturable, specific for ANP-related peptides, and displayed high affinity (Kd = 600 pM). When the relative concentrations of ANP binding sites were determined throughout the rat brain, the highest levels of ANP binding were localized to the circumventricular organs, including the area postrema and ...
Mark A. Oyama, Adrian Boswood, David J. Connolly, Stephen J. Ettinger, Philip R. Fox, Sonya G. Gordon, John E. Rush, D. David Sisson, Rebecca L. Stepien, Gerhard Wess, Faiez Zannad, Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease, Journal of the American Veterinary Medical Association, 2013, 243, 1, ...
Results With EA TEA, plasma proANP decreased following induction of anesthesia to the end of surgery (13%; 113±68 to 99±49 pmol/L; p=0.026), but that was not the case in the LA group (3%; 97±44 to 94±49 pmol/L; p=0.565) despite equal fluid balance (+1584±582 vs +1560±563 mL; p=0.888). Accordingly, the EA group required excessive treatment with vasopressors to maintain MAP ,60 mm Hg during surgery (2.7±2 vs 1.6±1.4 ephedrine boluses; p=0.033 and infusion of phenylephrine for 216±86 vs 58±91 min; p,0.001). Plasma proANP and fluid balance were correlated only for EA patients (r=0.44; 95% CI 0.04 to 0.91; p=0.033). ...
Principal Investigator:YAMAMOTO Tadashi, Project Period (FY):1991 - 1992, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Experimental pathology
Background: Chagas disease (CD) affects around 18 million people in Latin America. To determine the diagnostic and prognostic value of natriuretic peptides in patients with CD, we measured atrial (ANP) and brain natriuretic peptide (BNP), and compared the findings with other dilated cardiomyopathies (DCM). Methods: Blood samples were obtained from 111 CD patients, 62 patients with DCM due to other causes, and 43 gender- and age-matched healthy subjects. The CD and DCM patients were subdivided according to their NYHA classification. Natriuretic peptide concentrations were determined by immunoradiometric assays. Results: ANP and more pronounced BNP levels were increased in CD and DCM patients in relation to the NYHA class. Circulating BNP concentrations were higher in CD patients in NYHA classes I-II than in the corresponding DCM patients (p = 0.020). Importantly, ANP and BNP were already significantly elevated in CD patients without systolic ventricular dysfunction (p ≤ 0.001). In CD patients,
In the present study, blood samples were obtained at a single standardized time point, ie, in the morning on the third day of hospitalization. Because of the differences in release and metabolic clearance patterns of the natriuretic peptides, the timing of blood sampling is a crucial issue that may have affected the results of the study. Whether the relative prognostic value of the natriuretic peptides would have differed from the present results had another day of blood collection been selected remains speculative. Until larger studies have been conducted that compare the prognostic value of the natriuretic peptides in blood samples collected at multiple time points in the acute and subacute phase, our data should not be extrapolated to other time points of blood collection. However, the choice of day 3 was based on the following rationale. First, we wanted to choose a time point, based on available data in the literature, that would provide optimal reproducibility. In agreement with the ...
Relationship between natriuretic peptides and echocardiography parameters in patients with poorly regulated type 2 diabetes Magnus Dencker1, Martin Stagmo2, Mozhgan Dorkhan31Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Sciences, 2Division of Cardiology, 3Division of Diabetes and Endocrinology, Malmö University Hospital, Malmö, SwedenAbstract: This study evaluated the relationship between natriuretic peptide levels and a wide range of echocardiography parameters in a population of thirty-three patients with poorly regulated type 2 diabetes, and no known heart failure. Natriuretic peptides brain natriuretic peptide (BNP) and N-terminal prohormone BNP (NT-proBNP) were measured. Transthoracic echocardiography was performed and cardiac volumes and ejection fraction were measured. Doppler and tissue Doppler were measured and diastolic function was stratified according to recent guidelines. Very few echocardiography parameters were correlated with BNP or NT-proBNP levels.
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013 ...
Figure 1: Bradykinin metabolism and its relationship with two other vasoactive mediators: angiotensin and natriuretic peptides. ACE, angiotensin-converting enzyme; AI, angiotensin I; AII, angiotensin II; ANP, atrial natriuretic peptide; APP, aminopeptidase P; AT1, angiotensin II type I receptor; AT2, angiotensin II type II receptor; BK, bradykinin; BNP, brain natriuretic peptide; CNP, C-natruretic peptide; NEP, neutral endopeptidase 24.11; NPR-A, natriuretic peptide receptor type A; NPR-B, natriuretic peptide receptor type B ...
Salt-sensitive hypertension is a major risk factor for cardiovascular morbidity. Humans and mice with glucocorticoid receptor haploinsufficiency (GR+/−) are hypertensive, which in mice reflects activation of the renin-angiotensin-aldosterone system. Furthermore, glucocorticoid receptor (GR) gene polymorphisms associate with increased cardiovascular disease risk. Here we investigated the effect of dietary salt intake on blood pressure, heart and kidney in GR+/− mice. Adult male GR+/− mice and wild-type (WT) littermates were fed a sodium-enriched (3%Na+) or standard chow diet (0.3%Na+) for one week, after which mice were anaesthetised for measurement of blood pressure and sodium excretion. Separate cohorts were killed by decapitation and kidneys and hearts taken for histology and mRNA quantification. Cardiac atrial natriuretic peptide (ANP) mRNA levels were elevated in GR+/− mice and were markedly augmented following sodium-enriched diet [Chow:WT 100±7%, GR+/−146±8%; Sodium:WT 157±7%, ...
BACKGROUND: Previous research found precursor levels of the atrial natriuretic peptide (MR-proANP) to be promising prognostic markers. This study aims to validate these findings and describe patterns of MR-proANP in a large cohort of patients with lower respiratory tract infections. METHODS: We conducted a multicenter prospective cohort study, and measured MR-proANP in patients with lower respiratory tract infections on admission, and days 3, 5 and 7. The prognostic value of MR-proANP for predicting 30-day and 180-day mortalities was evaluated. We stratified MR-proANP levels a priori into quartiles, and compared it with severity of illness using the pneumonia severity index. RESULTS: A total of 1359 patients, including 925 with community-acquired pneumonia, were enrolled. The mortality risk at days 30 and 180 significantly increased with increasing MR-proANP quartiles ( 158-311 pmol/L, and ,311 pmol/L). This was true for low-risk, as well as high-risk subjects (pneumonia severity index classes ...
Hynynen, M.; Ilmarinen, R., Tikkanen, I., Fyhrquist, F. (1993). "Plasma atrial natriuretic factor during cold-induced diuresis ...
Effects on renal hemodynamics and atrial natriuretic factor". Gastroenterology. 101 (4): 1060-7. doi:10.1016/0016-5085(91)90734 ... including atrial natriuretic factor, prostacyclin, thromboxane A2, and endotoxin. In addition to this, it has been observed ... Three independent risk factors for the development of HRS in cirrhotics have been identified: liver size, plasma renin activity ... 1993). "Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites". Gastroenterology. ...
March 1994). "Atrial natriuretic factor in hypertensive and normotensive diabetic patients". Diabetes Care. 17 (3): 195-200. ... there are no changes in perfusion or in atrial natriuretic peptide levels up until the very late stages of the disease, when ... Abordo EA, Thornalley PJ (August 1997). "Synthesis and secretion of tumour necrosis factor-alpha by human monocytic THP-1 cells ... several factors have been implicated in the pathogenesis of the disease. Etiologically, four main causes are responsible for ...
1985) Atrial natriuretic factor: a hormone produced by the heart. Science 230: 767-770 (doi:10.1126/science.2932797 PMID ... In 1980, this work led to his discovery and isolation of atrial natriuretic peptide (ANP), a polypeptide hormone secreted by ... 1983) The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties. Biochem Biophys Res Commun ... best known for his discovery of atrial natriuretic peptide, a polypeptide hormone secreted by heart muscle cells. Born in ...
Wyss, DF; Lahm, HW; Manneberg, M; Labhardt, AM (February 1991). "Anantin--a peptide antagonist of the atrial natriuretic factor ... a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of ...
The atrioventricular canal signaling cascade involves the atrial natriuretic factor gene (ANF). This gene is one of the first ... T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans. ... T-box factor and NK2-homeobox factor binding element are involved in the repression of the atrioventricular canal without ... The molecule Tbx-2 is a transcription factor in the T box transcription factor family. Tbx2 helps form the outflow tract and ...
Kim TG, Chen J, Sadoshima J, Lee Y (2005). "Jumonji represses atrial natriuretic factor gene expression by inhibiting ... "Nitric oxide induces gene expression of jumonji and retinoblastoma 2 protein while reducing expression of atrial natriuretic ... Jarid2 (jumonji, AT rich interactive domain 2) is a protein coding gene that functions as a putative transcription factor. ... and atrial enlargement. Homozygous mutants of Jarid2 are found to die soon after birth. Overexpression of the mouse Jarid2 gene ...
Böhlen LM, de Courten M, Hafezi F, Shaw S, Riesen W, Weidmann P (June 1994). "Insulin sensitivity and atrial natriuretic factor ... c-Fos and Fra1 are both components of the transcription factor AP-1, and in the year 2000, Hafezi and his colleagues presented ...
2004). "ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells". ... 2004). "Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells ...
"Left atrial function and atrial natriuretic factor/cyclic guanosine monophosphate changes in DDD and VVI pacing modes". Am. J. ... "Total sympathetic activity and atrial natriuretic factor levels in VVI and DDD pacing with different atrioventricular delays ... and decreased left atrial total emptying fraction associated with ventricular pacing. The loss of physiologic timing of atrial ... Atrial contraction against a closed tricuspid valve can cause pulsation in the neck and abdomen, headache, cough, and jaw pain ...
Effects on renal hemodynamics and atrial natriuretic factor". Gastroenterology. 101 (4): 1060-7. doi:10.1016/0016-5085(91)90734 ... including atrial natriuretic factor,[16] prostacyclin, thromboxane A2,[17] and endotoxin.[4] In addition to this, it has been ... 1993). "Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites". Gastroenterology. ... which is mediated by factors released by liver disease.[4][12] Nitric oxide,[13] prostaglandins,[2][14] and other vasoactive ...
... which encodes the precursor of cardiodilatin-related peptide and atrial natriuretic factor. NPPA-AS1 is alternatively spliced. ... Long noncoding RNA Annilo T, Kepp K, Laan M (2009). "Natural antisense transcript of natriuretic peptide precursor A (NPPA): ...
Atrial natriuretic peptide; (ANP), atrial natriuretic factor; (ANF), atrial natriuretic hormone; (ANH), Cardionatrine, ... He XL, Dukkipati A, Garcia KC (2006). "Structural determinants of natriuretic peptide receptor specificity and degeneracy.". J ... இதயம்: சோடியச்சிறுநீர்மைப் புரதக்கூறு (Natriuretic peptide) (இதயியச் சோடியச்சிறுநீர்மைப் புரதக்கூறு (ANP), மூளைசார் ... Potter LR, Yoder AR, Flora DR, Antos LK, Dickey DM (2009). "Natriuretic peptides: their structures, receptors, physiologic ...
... for natriuretic factors such as atrial natriuretic factor (ANF). GC-C (GUCY2C): for guanylin and uroguanylin. GC-D (GUCY2D) GC- ...
... "p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene". The Journal ... Transcription factor GATA-5 is a protein that in humans is encoded by the GATA5 gene. The protein encoded by this gene is a ... The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for ... Gata5 is a transcription factor. Gata5 regulates the proper development of the heart. Early in embryo development, Gata5 helps ...
Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene ... Assisted by several other initiation factors (eIF1 and eIF1A, eIF5, eIF3, polyA binding protein) it is recruited to the 5′ end ... which leads atrial septal defect in the heart. The ability of the Kozak sequence to start translation can result in novel ... "A mutation in the Kozak sequence of GATA4 hampers translation in a family with atrial septal defects". American Journal of ...
Peptide hormones such as the atrial natriuretic factor activate membrane-bound GC, while soluble GC (sGC) is typically ...
A stimulant, atrial natriuretic factor (ANF) increases cGMP production in the kidneys, which increases function of the ... and also suggests that additional research be conducted to identify the upstream and downstream factors in CNGC-mediated signal ...
Examples are Aβ, IAPP, Atrial natriuretic factor (in isolated atrial amyloidosis), and Calcitonin (in medullary carcinoma of ... Historical classification systems were based on clinical factors. Until the early 1970s, the idea of a single amyloid substance ... caused by amyloid deposition in the blood vessels and reduced activity of thrombin and factor X, two clotting proteins that ...
They also contain neurons with receptors for angiotensin, atrial natriuretic factor, endothelin and relaxin, each of which ... Estrogen receptor (ER) has been shown to transactivate other transcription factors in this manner, despite the absence of an ... Releasing hormones (also called releasing factors) are produced in hypothalamic nuclei then transported along axons to either ... and from low-pressure atrial volume receptors, is mediated by others. In the rat, stimulation of the vagina also causes ...
R J Winquist, E P Faison, S A Waldman, K Schwartz, F Murad, and R M Rapoport (1984) Atrial natriuretic factor elicits an ... He is known for his work in atrial natriuretic factor intracellular signaling through guanylate cyclase (GC), and the relation ... His most cited articles are: SA Waldman, RM Rapoport, F Murad (1984) Atrial natriuretic factor selectively activates ... Experimental Therapeutics His early career was devoted to characterize the receptor-mediated responses to atrial natriuretic ...
Silencer Element-Neuron-Restrictive Silencer Factor System Regulates Basal and Endothelin 1-Inducible Atrial Natriuretic ... See also: Atrial natriuretic peptide. REST/NRSF in conjunction with RE1/NRSE also acts outside the nervous system as regulators ... Current research has linked RE1/NRSE activity with the regulation of the expression of the atrial natriuretic peptide (ANP) ... "Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its ...
... atrial natriuretic factor - atrial natriuretic factor receptor - Avogadro's number - axon - B cell - bacteria - bacterial ... transforming growth factor - transforming growth factor alpha - transforming growth factor beta - transforming growth factor ... peptide elongation factor - peptide elongation factor tu - peptide fragment - peptide initiation factor - peptide receptor - ... nerve growth factor - nerve growth factor receptor - nerve tissue protein - nerve tissue protein S 100 - nervous system - ...
Serine/threonine-specific protein kinase, as in bone morphogenetic protein Guanylate cyclase, as in atrial natriuretic factor ... Examples of the enzymatic activity include: Receptor tyrosine kinase, as in fibroblast growth factor receptor. Most enzyme- ... Alexander SP, Mathie A, Peters JA (February 2007). "Catalytic receptors: Natriuretic peptide family". Br. J. Pharmacol. 150 ...
... such as atrial natriuretic factor eventually leading to left ventricular hypertrophy which often progresses to heart failure. ... Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former ... "The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts". J. Mol. Cell ... Zhou J, Tan T, Tian Y, Zheng B, Ou JH, Huang EJ, Yen TS (July 2011). "Krüppel-like factor 15 activates hepatitis B virus gene ...
... natriuretic peptides MeSH D06.472.699.584.500 - atrial natriuretic factor MeSH D06.472.699.584.625 - natriuretic peptide, brain ... epidermal growth factor MeSH D06.472.317.400 - gastric inhibitory polypeptide MeSH D06.472.317.410 - gastrin-releasing peptide ... thymic factor, circulating MeSH D06.472.910.800 - thymopoietins MeSH D06.472.910.800.850 - thymopentin MeSH D06.472.910.850 - ... MeSH D06.472.699.584.750 - natriuretic peptide, c-type MeSH D06.472.699.587 - pancreatic polypeptide MeSH D06.472.699.590 - ...
... atrial natriuretic factor MeSH D08.811.520.650.800 - phosphatidylinositol diacylglycerol-lyase MeSH D08.811.600.075 - ... factor viia MeSH D08.811.277.656.300.760.310 - factor ixa MeSH D08.811.277.656.300.760.315 - factor xa MeSH D08.811.277.656. ... complement factor b MeSH D08.811.277.656.300.760.200 - complement factor d MeSH D08.811.277.656.300.760.210 - complement factor ... 300.760.320 - factor xia MeSH D08.811.277.656.300.760.324 - factor xiia MeSH D08.811.277.656.300.760.353 - furin MeSH D08.811. ...
... a component of the EarthScope USArray project Atrial natriuretic peptide, or atrial natriuretic factor, a hormone America Needs ... or anti-nuclear factor in blood Array Network Facility, ...
Serum levels of tumor necrosis factor alpha, brain and atrial natriuretic peptide, and angiotensin-converting enzyme 2, markers ...
Silencer Element-Neuron-Restrictive Silencer Factor System Regulates Basal and Endothelin 1-Inducible Atrial Natriuretic ... Current research has linked RE1/NRSE activity with the regulation of the expression of the atrial natriuretic peptide (ANP) ... "Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its ... The best example of this is the Neuronal-Restrictive Silencer Factor (NRSF) that is produced by the REST gene. The REST gene ...
This causes heart muscle cells to secrete the hormone atrial natriuretic peptide (ANP) into the blood. This acts on the kidneys ... The partial pressure of carbon dioxide is more of a deciding factor in the monitoring of pH.[37] However, at high altitude ( ... However, the compensating mechanisms eventually wear out or are disrupted by a new complicating factor (such as the advent of a ... However, warming has exacerbated droughts, making water the actual limiting factor on land. When sunlight is plentiful and the ...
péptida atrial-natriurétik (atrial-natriuretic peptide, ANP, ogé atriopéptin). *kalsitonin. *kolésistokinin (CCK) ... faktor pertumbuhan (growth factor). Rujukan[édit , édit sumber]. *Hormone, Wikipédia édisi basa Inggris per 17 Nopémber 2005 ...
Atrial-natriuretic peptide (ANP) Cardiac myocytes. *Brain natriuretic peptide (BNP) Cardiac myocytes ... Insulin-like growth factor (IGF) (mainly) Hepatocytes. *Angiotensinogen Hepatocytes. *Thrombopoietin Hepatocytes. *Pancreas ...
Atrial-natriuretic peptide (ANP). *Áicsin Auxin. *Azadirachtin A - C35H44O16 ...
... and atrial natriuretic peptide, among others. The kidneys excrete a variety of waste products produced by metabolism into the ... The two factors work together to return the plasma osmolality to its normal levels. ... "Normal kidney size and its influencing factors - a 64-slice MDCT study of 1.040 asymptomatic patients". BMC Urology. 9 (1): 19 ...
Peptide hormones such as the atrial natriuretic factor activate membrane-bound GC, while soluble GC (sGC) is typically ...
... can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A ... and individual patient factors such as the likelihood of relapse and the duration of corticosteroid treatment. Gradual ... "Glucocorticoids improve renal responsiveness to atrial natriuretic peptide by up-regulating natriuretic peptide receptor-A ...
... a reduction in the brain natriuretic peptide (BNP) and in the atrial natriuretic peptide (ANP). GDF11 also causes an increase ... transforming growth factor beta receptor binding. • growth factor activity. • GO:0001948 protein binding. ... Growth differentiation factor 11 (GDF11) also known as bone morphogenetic protein 11 (BMP-11) is a protein that in humans is ... "Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy". Cell. 153 (4): 828-39 ...
Examples include the heart (atrial natriuretic peptide); gastrointestinal tract organs (gastrin, secretin, and others); the ... It may act directly, or indirectly via insulin-like growth factors (IGFs). GH mobilizes fats, stimulates protein synthesis, and ... Dysfunction in the adrenal gland could be due to primary or secondary factors and can result in hypercortisolism or ...
growth factor binding. • peptide hormone binding. • protein binding. • cytokine receptor activity. • proline-rich region ... insulin-like growth factor receptor signaling pathway. • multicellular organism metabolic process. • JAK-STAT cascade. • JAK- ... Atrial natriuretic factor *NPR3. *Calcitonin. *Cholecystokinin *A. *B. *VIP. Opioid receptors. *Delta ...
Risk factors for kidney disease include diabetes, high blood pressure, family history, older age, ethnic group and smoking. For ... Atrial natriuretic peptide. *Renin. *Erythropoietin. *Calcitriol. *Prostaglandins. Fluid balance. Body water: Intracellular ...
Atrial natriuretic peptide receptor. References[edit]. *^ a b c GRCh38: Ensembl release 89: ENSG00000113389 - Ensembl, May 2017 ... 1yk0: structure of natriuretic peptide receptor-C complexed with atrial natriuretic peptide ... Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3, is an atrial ... 2004). "Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans". Stroke. 35 (4): 814-8. doi: ...
Insulin and IAPP are regulated by similar factors since they share a common regulatory promoter motif.[11] The IAPP promoter is ... Natriuretic peptides (ANP, BNP, CNP, urodilatin). *Nesfatin-1. *Neuromedin B. *Neuromedin N ... AANF/Isolated atrial. Brain. *Familial amyloid neuropathy. *ACys+ABri/Cerebral amyloid angiopathy ... In particular, the impaired processing of proIAPP that occurs at the N-terminal cleavage site is a key factor in the initiation ...
Wandering pacemaker · Ectopic pacemaker/Ectopic beat · Parasystole · Multifocal atrial tachycardia · Pacemaker syndrome ... Wang TJ, Larson MG, Levy D; एवं अन्य (2004). "Plasma natriuretic peptide levels and the risk of cardiovascular events and death ... स्रोत: www.americanheart.org, www.world-heart-federation.org/cardiovascular-health/cardiovascular-disease-risk-factors/) ... "Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The ...
It has been recently seen that intrarenal sodium handling abnormality is related to Atrial Natriuretic Peptide resistance is ... Factors associated with a poorer prognosis in these cases include level of proteinuria, blood pressure control and kidney ... Hyperlipidaemia is caused by two factors: *Hypoproteinemia stimulates protein synthesis in the liver, resulting in the ...
... atrial natriuretic peptide, brain natriuretic peptide, and cortisol.[2] ... "Fat-specific protein 27 inhibits lipolysis by facilitating the inhibitory effect of transcription factor Egr1 on transcription ...
Atrial natriuretic factor *NPR3. *Calcitonin. *Cholecystokinin *A. *B. *VIP. Opioid receptors. *Delta ...
Atrial natriuretic peptide inhibits AVP secretion, in part by inhibiting Angiotensin II-induced stimulation of AVP secretion.[ ... Vasoconstriction, gluconeogenesis, platelet aggregation, and release of factor VIII and von Willebrand factor; social ... "Angiotensin II-stimulated secretion of arginine vasopressin is inhibited by atrial natriuretic peptide in humans". American ... Many factors influence the secretion of vasopressin: *Ethanol (alcohol) reduces the calcium-dependent secretion of AVP by ...
Epigenetic Downregulation of Atrial Natriuretic Peptide but not Vasopressin mRNA Expression in Females with Eating Disorders is ... Treatment and triggering factors". Acta Psychiatrica Scandinavica. Supplementum. 361: 44-9. PMID 2291425.. ... Lindberg L, Hjern A (2003). "Risk factors for anorexia nervosa: a national cohort study". The International Journal of Eating ... Lee H, Oh JY, Sung YA, Chung H, Cho WY (2009). "The prevalence and risk factors for glucose intolerance in young Korean women ...
positive regulation of CREB transcription factor activity. • opioid receptor signaling pathway. • immune response. • ... cellular response to growth factor stimulus. • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide ... "Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of ...
They also contain neurons with receptors for angiotensin, atrial natriuretic factor, endothelin and relaxin, each of which ... Estrogen receptor (ER) has been shown to transactivate other transcription factors in this manner, despite the absence of an ... Releasing hormones (also called releasing factors) are produced in hypothalamic nuclei then transported along axons to either ... and from low-pressure atrial volume receptors, is mediated by others. In the rat, stimulation of the vagina also causes ...
"Meta-analysis of B type natriuretic peptide and N-terminal pro B natriuretic peptide in the diagnosis of clinical heart failure ... It is now used in only a small number of people with refractory symptoms, who are in atrial fibrillation and/or who have ... October 2003). "Aldosterone stimulates epidermal growth factor receptor expression". J. Biol. Chem. 278 (44): 43060-66. doi: ... An elevated B-type natriuretic peptide (BNP) is a specific test indicative of heart failure. Additionally, BNP can be used to ...
... and other growth factors. ... Atrial natriuretic factor *NPR3. *Calcitonin. *Cholecystokinin ...
This receptor is now most commonly referred to as the opioid growth factor receptor (OGFr).[30][31] ... Zagon IS, Verderame MF, McLaughlin PJ (February 2002). "The biology of the opioid growth factor receptor (OGFr)". Brain Res. ... and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans". Brain Res. 856 (1-2): 75-83. doi:10.1016/ ... belongs to a family of transcription factors and is positioned in the nucleus of the neuron. When the PKA is activated, it ...
Atrial natriuretic peptide receptor. *Aurein. *Autophagy-related protein 101. *Auxiliary Activity family 9 ... Azoospermia factor. B. *BAALC. *Bacillus haemolytic enterotoxin. *Bacterial binding protein-dependent transporter ...
It has been shown that PDE2 lowers cAMP through increased cGMP caused by atrial natriuretic peptide (ANP) resulting in ... It has been speculated that tumor necrosis factor-alpha (TNFα) might regulate the function of PDE2 in endothelial cells and ... "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood. 105 (9 ... "cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes". J. Clin. ...
... has exactly the opposite function of the atrial natriuretic hormone secreted by the heart.[4] ... Interrelationship of regulatory factors". Am J Med. 53 (5): 595-605. doi:10.1016/0002-9343(72)90156-8. PMID 4342886.. ... Depending on cause and other factors, hyperaldosteronism can be treated by surgery and/or medically, such as by aldosterone ... Aldosterone synthesis is stimulated by several factors: *increase in the plasma concentration of angiotensin III, a metabolite ...
Attenuated forearm vasodilator response to atrial natriuretic factor in the elderly.. T L Jansen, P Smits, A C Tan, T Thien ... Attenuated forearm vasodilator response to atrial natriuretic factor in the elderly.. T L Jansen, P Smits, A C Tan and T Thien ... Attenuated forearm vasodilator response to atrial natriuretic factor in the elderly.. T L Jansen, P Smits, A C Tan and T Thien ... Atrial natriuretic factor was infused at six increasing dose steps into the brachial artery from 0.001 up to 0.3 microgram/min/ ...
Atrial natriuretic factor plays a significant role in body fluid homeostasis.. E H Blaine ... Atrial natriuretic factor (ANF) is a hormone with the physiological characteristics of a regulator of body fluid volume. It is ... Apparently other factors such as renal perfusion pressure, volume status, and renal nerve activity are important in determining ... the natriuretic response to a given level of peptide. We hypothesize that the role played by ANF in volume regulation is highly ...
Atrial natriuretic factor (ANF) exerts marked natriuretic, diure ... The physiological actions of the atrial peptide system are ... Atrial natriuretic factor (ANF) exerts marked natriuretic, diuretic and vasodilatory effects and has been demonstrated to ... Atrial Natriuretic Factor / metabolism, physiology*. Heart Failure / metabolism, physiopathology*. Humans. Hypertension / ... Cardiovascular and neurohormonal effects of atrial natriuretic peptide in conscious dog.... 2533478 - Response to atrial ...
The effects of synthetic atrial natriuretic factor on renin secretion were examined in anesthetized dogs with either a single ... Atrial Natriuretic Factor / pharmacology*. Blood Pressure / drug effects. Creatinine / metabolism. Denervation. Dogs. Female. ... In dogs with a single filtering kidney (Series 1, n = 6), a priming dose of atrial natriuretic factor (2 micrograms/kg, i.v.) ... The effects of synthetic atrial natriuretic factor on renin secretion were examined in anesthetized dogs with either a single ...
... Kidney Int. 1992 May;41(5):1115-33. doi: 10.1038/ki. ... This leads us to hypothesize that ANF is a "natriuretic" hormone with physiological significance. The primary function in ... humans is to regulate sodium homeostasis in response to changes in intravascular volume (cardiac atrial stretch). Induction of ...
Changes in atrial natriuretic factor and plasma renin activity in dogs infected with Trypanosoma brucei.. Ndungu JM1, Wright ... a marked reduction in the plasma concentration of atrial natriuretic factor (ANF) occurred in the terminal stage of the disease ...
What is atrial natriuretic factor? Meaning of atrial natriuretic factor as a finance term. What does atrial natriuretic factor ... Definition of atrial natriuretic factor in the Financial Dictionary - by Free online English dictionary and encyclopedia. ... Atrial natriuretic factor financial definition of atrial natriuretic factor https://financial-dictionary.thefreedictionary.com/ ... factor. (redirected from atrial natriuretic factor). Also found in: Dictionary, Thesaurus, Medical, Legal, Acronyms, ...
atrial natriuretic factor endothelin atrial natriuretic factor receptor guanylate cyclase endothelin receptor protein kinase C ... Inagami T: Atrial natriuretic factor. J Biol Chem 264: 3043-3046, 1989Google Scholar ... Rosenzweig A, Seidman CE: Atrial natriuretic factor and related hormones. Annu Rev Biochem 60: 229-255, 1991Google Scholar ... Interaction of atrial natriuretic factor and endothelin-1 signals through receptor guanylate cyclase in pulmonary artery ...
Browsing by Subject "Atrial Natriuretic Factor". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y ...
... for C-terminal atrial natriuretic factor (42% ± 6%) than for N-terminal atrial natriuretic factor (28% ± 4%), there were no ... N-terminal atrial natriuretic factor plasma levels in these vessels were 3031 ± 756 fmol/ml, 2264 ± 661 fmol/ml and 1618 ± 496 ... Plasma concentrations (mean ± S.E.M.) of C-terminal atrial natriuretic factor were 55.0 ± 6.1 fmol/ml, 31.2 ± 4.0 fmol/ml and ... Mesenteric, hepatic and splanchnic extraction of C-terminal and N-terminal atrial natriuretic factor was investigated in male ...
Effect of Atrial Natriuretic Factor on Bronchomotor Tone in the Normal Human Airway G. Hulks; G. Hulks ... G. Hulks, A. G. Jardine, J. M. C. Connell, N. C. Thomson; Effect of Atrial Natriuretic Factor on Bronchomotor Tone in the ... 1. Asthmatic patients bronchodilate in response to infused atrial natriuretic factor. We wished to determine whether the ... 5. It is concluded that pharmacological, but not pathophysiological, elevations of plasma atrial natriuretic factor may ...
Unrelated peptides did not displace atrial natriuretic factor. Fragments of atrial natriuretic factor displaced the labeled ... Vascular and adrenal receptors for atrial natriuretic factor in the rat.. E L Schiffrin, L Chartier, G Thibault, J St-Louis, M ... Vascular and adrenal receptors for atrial natriuretic factor in the rat.. E L Schiffrin, L Chartier, G Thibault, J St-Louis, M ... Vascular and adrenal receptors for atrial natriuretic factor in the rat.. E L Schiffrin, L Chartier, G Thibault, J St-Louis, M ...
Atrial Natriuretic Factor Guanylate Cyclase and C Type Receptor Mrnas in the Rat Heart. DJ Nunez, MJ Brown ... Atrial Natriuretic Factor Guanylate Cyclase and C Type Receptor Mrnas in the Rat Heart ... Atrial Natriuretic Factor Guanylate Cyclase and C Type Receptor Mrnas in the Rat Heart ... Atrial Natriuretic Factor Guanylate Cyclase and C Type Receptor Mrnas in the Rat Heart ...
... Ganga, M ; ... We report here that the atrial natriuretic factor ( ANF) promoter is a target of PITX2. PITX2A, PITX2B, and PITX2C isoforms ... We report here that the atrial natriuretic factor ( ANF) promoter is a target of PITX2. PITX2A, PITX2B, and PITX2C isoforms ... We report here that the atrial natriuretic factor ( ANF) promoter is a target of PITX2. PITX2A, PITX2B, and PITX2C isoforms ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
What is atrial natriuretic factor? Meaning of atrial natriuretic factor medical term. What does atrial natriuretic factor mean? ... Looking for online definition of atrial natriuretic factor in the Medical Dictionary? atrial natriuretic factor explanation ... Atrial Natriuretic Peptide. Synonym/acronym: Atrial natriuretic hormone, atrial natriuretic factor, ANF, ANH, APN. ... stable factor factor VII, one of the coagulation factors.. Stuart factor (Stuart-Prower factor) factor X, one of the ...
Atrial Natriuretic Factor Content of Brain Nuclei in Deoxycorticosterone Acetate-Salt Hypertension in the Rat. Helmut Geiger, ... Atrial Natriuretic Factor Content of Brain Nuclei in Deoxycorticosterone Acetate-Salt Hypertension in the Rat ... Atrial Natriuretic Factor Content of Brain Nuclei in Deoxycorticosterone Acetate-Salt Hypertension in the Rat ... Atrial Natriuretic Factor Content of Brain Nuclei in Deoxycorticosterone Acetate-Salt Hypertension in the Rat ...
Contrasting plasma atrial natriuretic factor concentrations during comparable natriuresis with infusions of atrial natriuretic ... The presence of atrial-natriuretic-factor receptors of ANF-R2 subtype in rat platelets. Coupling to adenylate cyclase/cyclic ... The effect of atrial natriuretic factor (ANF) on adenylate cyclase activity was studied in rat platelet membranes. ANF-(99-126 ... Differential internalization and processing of atrial-natriuretic-factor B and C receptor in PC12 cells Biochem J (June, 1991) ...
We evaluated the effect of NEP inhibition with SCH 39370 on the inactivation of atrial natriuretic factor (ANF) and on ... SCH 39370, a neutral metalloendopeptidase inhibitor, potentiates biological responses to atrial natriuretic factor and lowers ... SCH 39370, a neutral metalloendopeptidase inhibitor, potentiates biological responses to atrial natriuretic factor and lowers ... SCH 39370, a neutral metalloendopeptidase inhibitor, potentiates biological responses to atrial natriuretic factor and lowers ...
Atrial natriuretic factor (ANF) levels are elevated in rats bearing rejecting heart-lung allografts ... Circulating levels of atrial natriuretic factor and the response to synthetic atrial natriuretic factor auriculin b in patients ... Right atrial area raa pressure rap and heart rate hr predict plasma atrial natriuretic factor anf levels in children. ... Elevated left atrial pressure in conscious dogs increases plasma levels of atrial natriuretic factor like immunoreactivity. ...
The atrial natriuretic factor (ANF) receptor has been solubilized from bovine adrenal zona glomerulosa membranes with the ... Molecular characterization of the solubilized atrial natriuretic factor receptor from bovine adrenal zona glomerulosa.. S ... Molecular characterization of the solubilized atrial natriuretic factor receptor from bovine adrenal zona glomerulosa.. S ... Molecular characterization of the solubilized atrial natriuretic factor receptor from bovine adrenal zona glomerulosa.. S ...
Abstract 023: Development Of Molecular Beacons Targeting Atrial Natriuretic Factor Mrna For Live Cell Sorting. Brian Wile, ... Atrial natriuretic factor (ANF) is expressed significantly more in working cardiomyocytes than nodal cardiomyocytes. We ... Abstract 023: Development Of Molecular Beacons Targeting Atrial Natriuretic Factor Mrna For Live Cell Sorting ... Abstract 023: Development Of Molecular Beacons Targeting Atrial Natriuretic Factor Mrna For Live Cell Sorting ...
... has been proposed to be a site of atrial natriuretic factor (ANF) action. We carried out experiments in isolated perfused ... The inner medullary collecting duct (IMCD) has been proposed to be a site of atrial natriuretic factor (ANF) action. We carried ... Atrial Natriuretic Factor Inhibits Vasopressin-Stimulated Osmotic Water Permeability in Rat Inner Medullary Collecting Duct ... Atrial Natriuretic Factor Inhibits Vasopressin-Stimulated Osmotic Water Permeability in Rat Inner Medullary Collecting Duct ...
The effect that several substances may have on ANF release by atrial slices and on its tissular content was investigated. alpha ... Mechanisms of release of atrial natriuretic factor. I. Effect of several agonists and steroids on its release by atrial minces ... The effect that several substances may have on ANF release by atrial slices and on its tissular content was investigated. alpha ...
In order to determine whether there is a relationship between genetically determined salt-induced hypertension and atrial ... natriuretic factor (ANF), a radio-immunoassay for ANF was applied to the determination of immunoreactive ANF in plasma, atrium ... Increased Concentration of Plasma Immunoreactive Atrial Natriuretic Factor in Dahl Salt Sensitive Rats with Sodium Chloride- ... whether there is a relationship between genetically determined salt-induced hypertension and atrial natriuretic factor (ANF), a ...
apparatus, angiotensin II, aldosterone, renin, atrial natriuretic factor. Knowledge goals: List an example of an ... Unformatted text preview: apparatus, angiotensin II, aldosterone, renin, atrial natriuretic factor. Knowledge goals: List an ...
Atrial natriuretic factor ANF stimulates the release of -MSH from frog neurointermediate lobes in vitro Interaction with ... Atrial natriuretic factor stimulates renal dopamine uptake mediated by natriuretic peptide-type A receptor. Regulatory Peptides ... atrial natriuretic factor anf stimulates the release of alpha msh from frog neurointermediate lobes in vitro interaction with ... Atrial natriuretic factor (ANF) stimulates the release of alpha-MSH from frog neurointermediate lobes in vitro. Interaction ...
The effect of a 20-min infusion of atrial natriuretic factor (ANF) 99-126, 0.4 jxg/kg per min, on both urinary albumin and [ ... The effect of atrial natriuretic factor on urinary albumin and β2-microglobulin excretion in man ... The effect of atrial natriuretic factor on urinary albumin and β2-microglobulin excretion in man. Journal of Hypertension, 6(10 ...
An ampouled preparation of human atrial natriuretic factor, ANF-(99-126), was evaluated by 23 laboratories in 10 countries for ... Volemic status influences the response of plasma atrial natriuretic factor to positive airway pressure.. *P Beuret, F Feihl, J ... An ampouled preparation of human atrial natriuretic factor, ANF-(99-126), was evaluated by 23 laboratories in 10 countries for ... International collaborative study of the proposed international standard for atrial natriuretic factor on behalf of the AHA/ISH ...
  • Brenner BM, Ballermann BJ, Gunning ME, Zeidel ML: Diverse biological activities of atrial natriuretic peptides. (springer.com)
  • Leitman DC, Murad F: Comparison of binding and cyclic GMP accumulation by atrial natriuretic peptides in endothelial cells. (springer.com)
  • Unrelated peptides did not displace atrial natriuretic factor. (ahajournals.org)
  • The cleavage of the C-terminal tyrosine did not decrease the potency of atrial natriuretic factor, but further cleavage at the C-terminal dramatically reduced the affinity of the resulting peptides. (ahajournals.org)
  • Measurement and significance of circulating natriuretic peptides in cardiovascular disease. (semanticscholar.org)
  • These results suggest the existence of a central regulation exerted by natriuretic peptides on circulating ANF levels. (conicet.gov.ar)
  • Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. (novusbio.com)
  • The inhibitory effect of ANP on glutamate release is reversed by selectively activating protein kinase A. These results demonstrate strong presynaptic inhibition by natriuretic peptides in the brain and suggest important physiological and behavioral roles of PDE2A in modulating neurotransmitter release by negative crosstalk between cGMP-signaling and cyclic adenosine monophosphate-signaling pathways. (pnas.org)
  • In addition to GPCRs, a unique family of receptors known as membrane guanylyl cyclases (GCs) can be activated by neuropeptides such as natriuretic peptides to catalyze the intracellular production of cyclic guanosine monophosphate (cGMP) ( 2 , 3 ). (pnas.org)
  • Both natriuretic peptides and their receptors are expressed in several discrete brain areas ( 10 ⇓ ⇓ - 13 ), but it remains unclear how ANP affects behaviors and modulates synaptic transmission in the brain. (pnas.org)
  • Ten well-documented reviews on topics in the genetics, biochemistry, metabolism, cellular actions, system (cardiovascular and renal) actions, and roles in edematous states and hypertension of atrial natriuretic peptides. (annals.org)
  • A brief non-inclusive review on natriuretic peptides (NP), their receptors, and their main functional properties is presented. (scielo.br)
  • A SURPRISING SET of diversified functional properties of natriuretic peptides is being unveiled since their discovery and chemical characterization in the early 80s. (scielo.br)
  • Studies in the past decades further advanced the knowledge of the broad scope of the homeostatic role of natriuretic peptides. (scielo.br)
  • Thus, natriuretic peptides were shown not only to inhibit the renin-angiotensin-aldosterone system but also to affect many other actions of hormones, paracrines/ autocrines, cytokines and growth factors. (scielo.br)
  • Natriuretic peptides (ANP, BNP, and CNP) are a family of hormone/paracrine factors that are structurally related. (wikipedia.org)
  • ANP is secreted in response to: Stretching of the atrial wall, via Atrial volume receptors Increased Sympathetic stimulation of β-adrenoceptors Increased sodium concentration (hypernatremia), though sodium concentration is not the direct stimulus for increased ANP secretion Endothelin, a potent vasoconstrictor Three types of atrial natriuretic peptide receptors have been identified on which natriuretic peptides act. (wikipedia.org)
  • All natriuretic peptides are bound by the NPR-C.[citation needed] Maintenance of the ECF volume (space), and its subcompartment the vascular space, is crucial for survival. (wikipedia.org)
  • CNP-22 had the most potent inhibitory effect compared with other natriuretic peptides. (ahajournals.org)
  • When PDGF-BB-induced migration was separated into chemotactic and chemokinetic activities, the chemotactic component was strongly inhibited by these natriuretic peptides. (ahajournals.org)
  • Such inhibition by these natriuretic peptides was paralleled by an increase in the cellular level of cyclic GMP. (ahajournals.org)
  • These results suggest that natriuretic peptides, especially CNP-22, inhibit FCS- or PDGF-BB-stimulated SMC migration at least in part through a cyclic GMP-dependent process. (ahajournals.org)
  • Natriuretic peptides are a family of hormones involved in the control of fluid balance. (ahajournals.org)
  • In addition to their vasorelaxant and natriuretic effects, these natriuretic peptides have previously been shown to be able to inhibit serum- and PDGF-induced mitogenesis. (ahajournals.org)
  • Peptides that regulate the WATER-ELECTROLYTE BALANCE in the body, also known as natriuretic peptide hormones. (curehunter.com)
  • Recent studies have identified additional modes of action of the natriuretic peptides that may also confer cardioprotective benefits, especially in heart disease. (curehunter.com)
  • Natriuretic Peptides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Natriuretic Peptides" by people in Harvard Catalyst Profiles by year, and whether "Natriuretic Peptides" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Natriuretic Peptides" by people in Profiles. (harvard.edu)
  • D'Elia E, Iacovoni A, Vaduganathan M, Lorini FL, Perlini S, Senni M. Neprilysin inhibition in heart failure: mechanisms and substrates beyond modulating natriuretic peptides. (harvard.edu)
  • Beyond Natriuretic Peptides for Diagnosis and Management of Heart Failure. (harvard.edu)
  • Peptides of natriuretic-diuretic activity have been identified and implicated in the control of extracellular fluid volume and electrolyte homeostasis. (cags.org.ae)
  • Data involving natriuretic peptides provides the primary evidence that fluid retention in the form of increased intravascular volume is a cardiovascular risk factor. (jabfm.org)
  • While abnormally elevated levels of natriuretic peptides imply a diagnosis of heart failure, even when natriuretic peptide levels fall within the normal range, higher than average levels of BNP and ANP predict a number of adverse cardiovascular events: death from any cause, first major cardiovascular event, heart failure, atrial fibrillation, and stroke or transient ischemic attack, but not coronary heart disease. (jabfm.org)
  • 7 8 9 10 11 The relationship between these natriuretic peptides and survival is believed to be based mainly on their reflection of increased LV filling pressure secondary to LV dysfunction. (ahajournals.org)
  • Recent experimental studies have highlighted the potential role of the natriuretic peptides and aldosterone in mediating salt sensitivity. (pubmedcentralcanada.ca)
  • Binding of these natriuretic peptides to NPRA leads to activation of the particulate guanylate cyclase (pGC) catalytic domain which generates cGMP-dependent second messenger signaling cascade. (springer.com)
  • Mahinrad S, de Craen AJ, Yasar S, van Heemst D, Sabayan B. Natriuretic peptides in the central nervous system: Novel targets for cognitive impairment. (springer.com)
  • Moro C, Lafontan M. Natriuretic peptides and cGMP signaling control of energy homeostasis. (springer.com)
  • Using optogenetic stimulation and electrophysiological recordings, we show that both ANP and brain natriuretic peptide profoundly block glutamate release from MHb neurons. (pnas.org)
  • Another member of the membrane GC family, GC-A (also named NPR-A), is the receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), and its activation reduces blood pressure and volume in the cardiovascular system ( 7 ⇓ - 9 ). (pnas.org)
  • ANP is closely related to BNP (brain natriuretic peptide) and CNP (C-type natriuretic peptide), which all share a similar amino acid ring structure. (wikipedia.org)
  • These proteins mapped to select biological pathways such as endoplasmic reticulum stress response, cytoskeletal remodeling, and apoptosis and included known biomarkers of HF ( e.g. brain natriuretic peptide/atrial natriuretic factor and angiotensin-converting enzyme) and other indicators of presymptomatic functional impairment. (mcponline.org)
  • Echocardiographic characteristics and brain natriuretic peptide levels in cor pulmonale patients. (ebscohost.com)
  • An abstract of the article "Echocardiographic characteristics and brain natriuretic peptide levels in cor pulmonale patients," by N. Flessas and colleagues is presented. (ebscohost.com)
  • Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted by the myocytes of the atria and ventricles in response to stretch and pressure. (jabfm.org)
  • Previous data suggest that plasma brain natriuretic peptide (BNP) may increase proportionally more than plasma ANP after AMI and in chronic heart failure. (ahajournals.org)
  • Pandey KN, Pavlov SN, Inagami T: Identification and characterization of three distinct atrial natriuretic factor receptors. (springer.com)
  • Vascular and adrenal receptors for atrial natriuretic factor in the rat. (ahajournals.org)
  • Radioiodinated synthetic atrial natriuretic factor bound to a single class of high-affinity (KD = 0.1 nM) low-capacity receptors in a particulate fraction from blood vessels and adrenals. (ahajournals.org)
  • Our results suggest that these binding sites mediate the biological actions of atrial natriuretic factor in blood vessels and the adrenal, and that both receptors have similar specificities. (ahajournals.org)
  • The presence of atrial-natriuretic-factor receptors of ANF-R2 subtype in rat platelets. (portlandpress.com)
  • Atrial natriuretic factor (ANF) and C-type natriuretic peptide (CNP) receptors have been described in encephalic areas and nuclei related to the regulation of cardiovascular as well as sodium and water homeostasis. (conicet.gov.ar)
  • Influence of right and left atrial receptors on plasma concentrations of ADH and renin. (springer.com)
  • Atrial receptors and renal function. (springer.com)
  • Evidence of the atrial location of receptors influencing urine flow. (springer.com)
  • The possible role of cardiac atrial stress receptors in the induction of changes in urine flow. (springer.com)
  • This could be explained by exhaustion of cardiac stores of ANP & impaired responsiveness, of atrial stretch receptors in diabetes. (bu.edu.eg)
  • Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. (uniprot.org)
  • Atrial natriuretic factor receptors and signal transduction mechanisms. (stonel.info)
  • Atrial natriuretic factor (ANF) has been shown to bind to specific receptors on vascular smooth muscle cells (VSMC) and to cause an increase in intracellular cyclic (GMP (cGMP) content. (elsevier.com)
  • These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood volume. (wikipedia.org)
  • They are all cell surface receptors and designated: guanylyl cyclase-A (GC-A) also known as natriuretic peptide receptor-A (NPRA/ANPA) or NPR1 guanylyl cyclase-B (GC-B) also known as natriuretic peptide receptor-B (NPRB/ANPB) or NPR2 natriuretic peptide clearance receptor (NPRC/ANPC) or NPR3 NPR-A and NPR-B have a single membrane-spanning segment with an extracellular domain that binds the ligand. (wikipedia.org)
  • abstract = "Addition of atrial natriuretic factor (ANF) to the contraluminal side of the intestinal mucosa of a marine teleost, the winter flounder Pseudopleuronectes americanus, inhibits short-circuit current, net transepithelial fluxes of Na and Cl, and the unidirectional influx of Rb across the brush border membrane. (umn.edu)
  • Apparently other factors such as renal perfusion pressure, volume status, and renal nerve activity are important in determining the natriuretic response to a given level of peptide. (ahajournals.org)
  • Renal mechanisms for suppression of renin secretion by atrial natriuretic factor. (biomedsearch.com)
  • Renal blood flow remained significantly elevated (p less than 0.05) throughout the infusion, in contrast to renal blood flow in Series I. Similar results were obtained in a third series of dogs (n = 6) with a single denervated nonfiltering kidney, during sustained intrarenal arterial infusions of atrial natriuretic factor. (biomedsearch.com)
  • These results suggest that an increase in the sodium load delivered to the macula suppression of renin secretion by atrial natriuretic factor is mediated through its interactions with the two intrarenal receptor mechanisms, the renal vascular receptor and the macula densa. (biomedsearch.com)
  • We now report the presence of specific binding sites for atrial natriuretic factor in rat blood vessels (mesenteric and renal arteries) and adrenal capsules. (ahajournals.org)
  • Circulating prouroguanylin is processed to its active natriuretic form exclusively within the renal tubules. (semanticscholar.org)
  • To determine whether the renal responses to atrial natriuretic factor (ANF) are altered in the diabetic state, the diuretic and natriuretic responses to ANF (0.25 μg·kg -1 ·min -1 , i.v.) were measured in streptozotocin (STZ) induced diabetic (DIA) rats. (nebraska.edu)
  • Patel, KP & Zhang, PL 1990, ' Attenuated renal responses to atrial natriuretic factor in streptozotocin-induced diabetic rats ', Canadian journal of physiology and pharmacology , vol. 68, no. 3, pp. 425-430. (nebraska.edu)
  • The purpose of the present study was to determine whether endogenous atrial natriuretic factor participates in the maintenance of normal vascular pressure and renal function in ovine fetuses at 128 to 130 days' gestation. (elsevier.com)
  • Cheung, CY 1991, ' Role of endogenous atrial natriuretic factor in the regulation of fetal cardiovascular and renal function ', American journal of obstetrics and gynecology , vol. 165, no. 4, pp. 1558-1567. (elsevier.com)
  • Renal actions of synthetic Dendroaspis natriuretic peptide. (ebscohost.com)
  • Aldosterone and atrial natriuretic peptide (ANP) are both involved in renal sodium handling 7 , 8 and experimental studies strongly support important opposing roles for these hormones in BP regulation. (pubmedcentralcanada.ca)
  • Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and urodilatin (URO) represent a family of cardiac, vascular, and renal-derived hormones that play an essential role on the regulation of blood pressure, intravascular volume, and electrolyte homeostasis in all mammals. (springer.com)
  • Fernández BE, Correa AH, Choi MR. Atrial natriuretic factor stimulates renal dopamine uptake mediated by natriuretic peptide-type A receptor. (springer.com)
  • The primary function in humans is to regulate sodium homeostasis in response to changes in intravascular volume (cardiac atrial stretch). (nih.gov)
  • Cardiac myocytes store the 126-amino acid precursor of atrial natriuretic factor (pro-ANF), yet the mature, bioactive 28-amino acid peptide, ANF-(99-126), and the resulting N-terminal product, ANF-(1-98), are the forms of the hormone that are released by the heart and found in the circulation. (semanticscholar.org)
  • The concentration of calcium in heart muscle cells depends on many factors, such as the action of humoral substances, cardiac nerve activity, heart rate, and resting length of the myocardial fibers. (springer.com)
  • Plasma atrial natriuretic peptide (ANP) values in cardiac disease. (springer.com)
  • Using a conditional Hrt2 null allele, we show that cardiomyocyte-specific deletion of Hrt2 in mice results in ectopic activation of atrial genes in ventricular myocardium with an associated impairment of cardiac contractility and a unique distortion in morphology of the right ventricular chamber. (pnas.org)
  • Consistent with the atrialization of ventricular gene expression in Hrt2 mutant mice, forced expression of Hrt2 in atrial cardiomyocytes is sufficient to repress atrial cardiac genes. (pnas.org)
  • These findings reveal a ventricular myocardial cell-autonomous function for Hrt2 in the suppression of atrial cell identity and the maintenance of postnatal cardiac function. (pnas.org)
  • Atrial and ventricular cardiomyocytes, for example, display distinct gene expression patterns, contractile properties, and hormonal responses required for coordinated cardiac contractility. (pnas.org)
  • During embryogenesis, Hrt2 is expressed in the ventricular myocardium, but not in the atrial myocardium, and in the cardiac outflow tract and aortic arch arteries ( 5 , 9 ). (pnas.org)
  • Extracorporeal circulation inbluence on plasma atrial natriuretic peptide concentration in cardiac surgery patients' Chest. (nii.ac.jp)
  • Atrial natriuretic peptide (ANP) or atrial natriuretic factor (ANF) is a natriuretic peptide hormone secreted from the cardiac atria that in humans is encoded by the NPPA gene. (wikipedia.org)
  • Following stimulation of atrial cells, proANP is released and rapidly converted to the 28-amino-acid C-terminal mature ANP on the cell surface by the cardiac transmembrane serine protease corin. (wikipedia.org)
  • Myocardial hypertrophy is defined as a thickening of the myocardium, which results in a decrease in the size of the chamber of the heart, including the left and right ventricles, and is an important risk factor for subsequent cardiac morbidity and mortality. (scielo.br)
  • The cardiac natriuretic peptide system is activated after AMI. (ahajournals.org)
  • In this report, we present data from a cohort of 131 patients with documented AMI and a median follow-up time of 1293 days, and we compare the merit of these three members of the cardiac natriuretic peptide family as indicators of LV dysfunction, defined as LV ejection fraction ≤45%, and long-term survival after AMI. (ahajournals.org)
  • Kilić A, Bubikat A, Gassner B, Baba HA, Kuhn M. Local actions of atrial natriuretic peptide counteract angiotensin II stimulated cardiac remodeling. (springer.com)
  • A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy. (springer.com)
  • Margulies, KB & Burnett, JCJ 1990, ' Atrial natriuretic factor modulates whole kidney tubuloglomerular feedback ', American Journal of Physiology - Regulatory Integrative and Comparative Physiology , vol. 259, no. 1 28-1. (elsevier.com)
  • Atrial natriuretic factor: implications in congestive heart failure and hypertension. (biomedsearch.com)
  • The physiological actions of the atrial peptide system are discussed in relation to its potential role in the aetiology and treatment of hypertension and congestive heart failure (CHF). (biomedsearch.com)
  • 1. The influence of deoxycorticosterone acetate (DOCA)-salt hypertension on brain atrial natriuretic factor (ANF) in rats was investigated to elucidate the role of central ANF in a renin-independent model of experimental hypertension. (clinsci.org)
  • In order to determine whether there is a relationship between genetically determined salt-induced hypertension and atrial natriuretic factor (ANF), a radio-immunoassay for ANF was applied to the determination of immunoreactive ANF in plasma, atrium, hypothalamus and pons of Dahl salt-sensitive (S) and -resistant (R) rats which were fed high- or low-salt diet for 7 weeks. (ovid.com)
  • The common polymorphism in the atrial natriuretic peptide precursor gene (NPPA), +2238 T/C, was in the previous studies associated with hypertension as well as other cardiovascular conditions. (muni.cz)
  • A growing body of evidence suggests that obstructive sleep apnea is a major contributing factor in the development of essential hypertension. (aafp.org)
  • Plasma atrial natriuretic peptide in essential hypertension: effects of changes in dietary sodium. (ebscohost.com)
  • Examines the plasma atrial natriuretic peptide in essential hypertension. (ebscohost.com)
  • 1997) studied an insertion/deletion (I/D) dimorphism located in the second intron of the human atrial natriuretic factor (ANF) gene among 232 UAE nationals (112 normotensives and 120 hypertensives) from the Abu Dhabi Emirate, with a view to evaluating the value of this marker in relation to hypertension. (cags.org.ae)
  • Background: Studies evaluating the association between the atrial natriuretic peptide (ANP) genetic polymorphism and the risk of essential hypertension (EH) have reported inconsistent results. (mendeley.com)
  • The aim of this meta-analysis was to provide a more reliable estimation of the possible relationship between the atrial natriuretic peptide genetic polymorphism and the risk of essential hypertension (EH). (mendeley.com)
  • Conversely, the ANP T1766C gene polymorphism may be associated with the risk of essential hypertension, and the 1766C allele may be a protective factor against EH. (mendeley.com)
  • Nakayama T, Soma M, Takahashi Y, Rehemudula D, Kanmatsuse K, Furuya K. Functional deletion mutation of the 5'-flanking region of type A human natriuretic peptide receptor gene and its association with essential hypertension and left ventricular hypertrophy in the Japanese. (springer.com)
  • This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. (novusbio.com)
  • There are multiple forms of these so-called atrial natriuretic polypeptides (ANP), ranging in molecular weight from 3,000 to 13,000, and it has been suggested that all may derive from the same precursor. (cags.org.ae)
  • The cDNA of the natriuretic peptide precursor A gene encodes gamma-ANP, a polypeptide of 13,000 MW, whose C-terminal 28 amino acids are processed as alpha-ANP. (cags.org.ae)
  • Atrial natriuretic factor (ANF) appears to be synthesized as a large precursor, atrial pronatriodilatin. (cags.org.ae)
  • Atrial natriuretic factor (ANF) is a hormone with the physiological characteristics of a regulator of body fluid volume. (ahajournals.org)
  • Immunoreactive atrial natriuretic hormone levels increase in deoxycorticosterone acetate-treated pig. (biomedsearch.com)
  • This leads us to hypothesize that ANF is a "natriuretic" hormone with physiological significance. (nih.gov)
  • The hormone is known as Atrial Natriuretic Factor and was first discovered in 1981 by Adolfo de Bold, then at Queen's University (Kingston, Ont. (thefreedictionary.com)
  • Secreted by the heart, the hormone -- calledatrial natriuretic peptide (ANP) or atrial natriuretic factor -- can act as a diuretic, influencing fluid movement. (thefreedictionary.com)
  • The endothelial cell has a unique intrinsic feature: it produces a most potent vasopressor peptide hormone, endothelin (ET-1), yet it also contains a signaling system of an equally potent hypotensive hormone, atrial natriuretic factor (ANF). (springer.com)
  • Previous studies have shown that atrial natriuretic factor, a powerful vasorelaxant of precontracted vessels, inhibits the secretion of aldosterone stimulated by angiotensin II, adrenocorticotropic hormone, and potassium. (ahajournals.org)
  • Plasma levels of atrial natriuretic factor (α-ANF), aldosterone, and antidiuretic hormone (ADH) and urinary sodium excretion were measured before anesthesia, after sternotomy but before CPB, at 15 and 30 minutes of CPB, and at 15 and 30 minutes after discontinuation of CPB. (elsevier.com)
  • the myoendocrine cells in the atria of the mammalian heart synthesize and secrete a hormone called atrial natriuretic peptide (ANP), which causes natriuresis and diuresis. (springer.com)
  • Atrial natriuretic factor-a circulating hormone stimulated by volume loading. (springer.com)
  • The heart peptide hormone atrial natriuretic peptide (ANP) regulates blood pressure by stimulating guanylyl cyclase-A to produce cyclic guanosine monophosphate (cGMP). (pnas.org)
  • The atrial natriuretic factor (ANF) has been identified as a hormone that is involved in the regulation of water and electrolyte homeostasis and blood pressure. (elsevier.com)
  • Atrial natriuretic peptide (ANP), the most intensely studied member of the natriuretic peptide family, was initially thought to be exclusively a hormone that directly regulates salt excretion, induces vasorelaxation, and consequently participates in blood pressure-volume homeostasis. (scielo.br)
  • Proper glycosylation and phosphorylation of the type A natriuretic peptide receptor are required for hormone-stimulated guanylyl cyclase activity. (springer.com)
  • HPLC and Hormone Purification: Application to Atrial Natriuretic Factor 13. (routledge.com)
  • Samarel, Allen M. / Contractile activity modulates atrial natriuretic factor gene expression in neonatal rat ventricular myocytes . (elsevier.com)
  • The protein encoded by this gene belongs to the natriuretic peptide family. (novusbio.com)
  • Mutations in this gene have been associated with atrial fibrillation familial type 6. (novusbio.com)
  • The NPPA gene is expressed primarily in atrial myocytes and consists of 2 introns and three exons, with translation of this gene yielding a high molecular mass 151 amino acid polypeptide known as preproANP. (wikipedia.org)
  • 2002) carried out a case-controlled study on a group of 151 UAE nationals (62 normotensives with and without left ventricular hypertrophy and 89 hypertensives, also with and without left ventricular hypertrophy) with a view to evaluate the value of an insertion/deletion (I/D) dimorphism located in the second intron of the human atrial natriuretic factor gene in relation to left ventricular hypertrophy. (cags.org.ae)
  • The atrial natriuretic factor (ANF) gene is initially expressed throughout the myocardial layer of the heart, but during subsequent development, expression becomes limited to the atrial chambers. (elsevier.com)
  • We propose that the NKE and proximal GATA elements serve as crucial binding sites for assembly of a repressor complex that is required for atrial-specific expression of the ANF gene. (elsevier.com)
  • The mRNA levels of β-myosin heavy chain and atrial natriuretic factor were determined by real-time PCR to evaluate the presence of fetal phenotypes of gene expression. (scielo.br)
  • The natriuresis after CPB appears to be strongly associated with increased α-ANF, present for at least the first 30 minutes after CPB, which could reflect α-ANF release resulting from atrial distention during volume loading. (elsevier.com)
  • Relationships among natriuresis, atrial natriuretic peptide and insulin in insulin-dependent diabetes. (ebscohost.com)
  • B‐type natriuretic peptide (BNP), a member of the natriuretic peptide (NP) family, plays a critical role in the regulation of circulatory volume status, plasma renin‐aldosterone concentrations, natriuresis, and ultimately the maintenance of blood pressure (BP) levels. (ahajournals.org)
  • Plasma concentrations (mean ± S.E.M.) of C-terminal atrial natriuretic factor were 55.0 ± 6.1 fmol/ml, 31.2 ± 4.0 fmol/ml and 23.5 ± 3.3 fmol/ml (n = 12) in the abdominal aorta, the portal vein and the hepatic vein, respectively. (uni-muenchen.de)
  • No significant difference was seen in atrial concentrations of ANF between S and R rats. (ovid.com)
  • Central volume expansion and pharmacological concentrations of atrial natriuretic factor (ANF) are known to attenuate this response. (elsevier.com)
  • Atrial natriuretic peptide concentrations in plasma of children with congenital heart and pulmonary diseases. (springer.com)
  • Values tended to peak on the 3rd and 4th postoperative days in all groups, although significantly elevated postoperative ANF concentrations occurred only in the coronary artery bypass group where the levels increased by a factor of 3.2 (95% CI: 1.3 to 7.5). (elsevier.com)
  • Urine flow rate was suppressed for as long as plasma atrial natriuretic factor concentrations were reduced. (elsevier.com)
  • In response to atrial natriuretic factor antiserum injection, plasma angiotensin II concentrations were increased, whereas plasma arginine vasopressin concentrations were unchanged. (elsevier.com)
  • The aim of the study was to evaluate serum concentrations of biomarkers of inflammation and endothelial function: tumour necrosis factor alpha (TNF-α), endothelin-1 (ET-1), and N-terminal fragment of pro-atrial natriuretic peptide (NTpro-ANP) in hypertensive and normotensive children. (viamedica.pl)
  • Atrial natriuretic peptide concentrations in pre-eclampsia. (ebscohost.com)
  • Reduced circulating natriuretic peptide concentrations are independently associated with insulin resistance and type 2 diabetes, while increased natriuretic peptide levels appear to be protective. (ebscohost.com)
  • The calculated forearm spillover of the second messenger of atrial natriuretic factor, cyclic guanosine monophosphate, significantly increased from baseline values of 1.2 +/- 1.1 and 0.7 +/- 0.5 pmol/min/100 ml in young and elderly subjects, respectively, up to 23.2 +/- 5.0 and 30.5 +/- 7.0 pmol/min/100 ml during the highest dose of atrial natriuretic factor (both p less than 0.01 versus baseline). (ahajournals.org)
  • In dogs with a single filtering kidney (Series 1, n = 6), a priming dose of atrial natriuretic factor (2 micrograms/kg, i.v.) followed by sustained intravenous infusions at doses of 200 and 400 ng/kg/min for 20 minutes each produced striking decrements (p less than 0.05) in renin secretion, from 1083 +/- 322 to 205 +/- 120 and 286 +/- 168 ng of angiotensin I per minute. (biomedsearch.com)
  • The effect of atrial natriuretic factor (ANF) on adenylate cyclase activity was studied in rat platelet membranes. (portlandpress.com)
  • McMurray, J. , Seidelin, P. H. , Howey, J. E.A. , Balfour, D. J. and Struthers, A. D. (1988) The effect of atrial natriuretic factor on urinary albumin and β2-microglobulin excretion in man. (gla.ac.uk)
  • The venorelaxant effect of atrial natriuretic factor in man was studied using the dorsal hand vein technique. (ox.ac.uk)
  • SCH 39370, a neutral metalloendopeptidase inhibitor, potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats. (aspetjournals.org)
  • Photoaffinity labelling of atrial natriuretic factor (ANF)-R1 receptor by underivatized 125 I-ANF. (portlandpress.com)
  • Kinetic analysis of internalization, recycling and redistribution of atrial natriuretic factor-receptor complex in cultured vascular smooth-muscle cells. (portlandpress.com)
  • Molecular characterization of the solubilized atrial natriuretic factor receptor from bovine adrenal zona glomerulosa. (aspetjournals.org)
  • The atrial natriuretic factor (ANF) receptor has been solubilized from bovine adrenal zona glomerulosa membranes with the nonionic detergent octyl-beta-D-glucoside. (aspetjournals.org)
  • Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). (uniprot.org)
  • Vasoconstrictorーinduced heterologous downーregulation of vascular atrial natriuretic peptide receptor' Eur.J.Pharmacol. (nii.ac.jp)
  • Binding of a natriuretic peptide induces a conformational change in the receptor that causes receptor dimerization and activation. (wikipedia.org)
  • Expressions of natriuretic peptide receptor-B (NPRB) and apoptosis-related genes in retina, including Bcl-xL, BAX, and μ-calpain, were analyzed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). (arvojournals.org)
  • Most of the biological actions of ANP, BNP, and URO are mediated by activation of the natriuretic peptide receptor type A (NPRA), also designated as guanylyl cyclase-A/ natriuretic peptide receptor type A (GC-A/NPRA). (springer.com)
  • Alexander MR, Knowles JW, Nishikimi T, Maeda N. Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A-/-apolipoprotein E-/- mice. (springer.com)
  • Natriuretic peptide receptor A inhibition suppresses gastric cancer development through reactive oxygen species-mediated G2/M cell cycle arrest and cell death. (springer.com)
  • Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling. (springer.com)
  • Guanylyl cyclase/atrial natriuretic peptide receptor-A: role in the pathophysiology of cardiovascular regulation. (springer.com)
  • Endocytosis and trafficking of natriuretic peptide receptor-A: potential role of short sequence motif. (springer.com)
  • CNP, which was first identified in the porcine brain, is the most recently identified member of the natriuretic peptide family. (ahajournals.org)
  • Immunoreactive atrial natriuretic factor (ANF) levels were measured preoperatively and for 5 days postoperatively in 22 patients undergoing cardiothoracic surgery. (elsevier.com)
  • Examines the concentration of plasma immunoreactive atrial natriuretic peptide in pre-eclampsia. (ebscohost.com)
  • Plasma acidification increases atrial natriuretic peptide as measured by radioimmunoassay. (semanticscholar.org)
  • Radioimmunoassay of atrial natriuretic factor: human plasma levels. (springer.com)
  • Measurement of atrial natriuretic peptide in bovine plasma and urine by radioimmunoassay' Jpn.J.Vet.Sci. (nii.ac.jp)
  • Fasting blood sample was also taken from each individual and the serum was separated and the atrial natriuretic factor [peptide] was assayed by a competitive radioimmunoassay . (bvsalud.org)
  • Mesenteric, hepatic and splanchnic extraction of C-terminal and N-terminal atrial natriuretic factor was investigated in male Sprague-Dawley rats. (uni-muenchen.de)
  • We evaluated the effect of NEP inhibition with SCH 39370 on the inactivation of atrial natriuretic factor (ANF) and on cardiovascular function in rats. (aspetjournals.org)
  • The hypotensive response to injection of ANF (30 micrograms/kg i.v.) in spontaneously hypertensive rats (-38 +/- 6 mm Hg vs. -13 +/- 2 mm Hg in the control) and the diuretic and natriuretic responses to ANF in normal rats were potentiated by SCH 39370 (30 mg/kg s.c.), respectively. (aspetjournals.org)
  • Atrial natriuretic factor (ANF) levels measured 6 days after transplantation revealed a significantly (p less than .005) higher mean ANF concentration in rats bearing a rejecting heart-lung allograft (642 +/- 148.0 pg/ml) compared to rats bearing a heart-lung allograft not undergoing rejection (200.8 +/- 13.07 pg/ml). (eurekamag.com)
  • Concomitant administration of ghrelin with MI treated rats of this study appeared to show a considerable protection of the atrial tissues . (bvsalud.org)
  • Recent reports have described modulation of atrial natriuretic factor (ANF) secretion by atrial stretch, increased Na + concentration, and a variety of hormones and neurotransmitters. (elsevier.com)
  • Rosenzweig A, Seidman CE: Atrial natriuretic factor and related hormones. (springer.com)
  • Effects of female sex hormones on atrial natriuretic factor g. (mysciencework.com)
  • ANP is one of a family of nine structurally similar natriuretic hormones: seven are atrial in origin. (wikipedia.org)
  • 2. Changes in airway resistance, as determined by specific airway conductance, were measured in eight normal subjects in response to intravenous infusion of atrial natriuretic factor at doses of 0.5, 2 and 10 pmol rnin −1 kg −1 . (portlandpress.com)
  • Circulating atrial natriuretic factor in the fetus was immunoneutralized by an intravenous bolus injection of an atrial natriuretic factor antiserum at a dilution of 1:2000 (low dose, n = 7) or 1:400 (high dose, n = 6). (elsevier.com)
  • Primary aldosteronism and thyroid disorders in atrial fibrillation: A Swedish nationwide case-control study. (medscape.com)
  • In dogs with a single denervated nonfiltering kidney (Series 2, n = 6), infusion of atrial natriuretic factor at these doses also produced marked inhibition (p less than 0.05) of renin secretion, from 311 +/- 98 to 72 +/- 22 and 91 +/- 37 ng of angiotensin I per minute. (biomedsearch.com)
  • However, early studies already demonstrated that ANP, in addition to its natriuretic, vasoactive and blood pressure lowering effects, is a powerful inhibitor of the renin-angiotensin-aldosterone system (2-4). (scielo.br)
  • When beagle dogs were infected with Trypanosoma brucei, a marked reduction in the plasma concentration of atrial natriuretic factor (ANF) occurred in the terminal stage of the disease during weeks 3 and 4. (nih.gov)
  • In the high-dose group, plasma atrial natriuretic factor concentration was significantly reduced by 65 ± 14 pg/ml from basal levels of 165 ± 12 pg/ml within 10 minutes and remained reduced for the 90-minute period after the injection. (elsevier.com)
  • Increase in the concentration of atrial natriuretic peptide. (ebscohost.com)
  • Atrial myocytes after myocardial infarction is often associated with subsequent heart failure , which could lead to a fatal outcome . (bvsalud.org)
  • Background Elevated plasma levels of atrial natriuretic peptide (ANP) and the N-terminal fragment of the ANP prohormone (N-ANP) are associated with decreased left ventricular function and decreased long-term survival after acute myocardial infarction (AMI). (ahajournals.org)
  • The effects of synthetic atrial natriuretic factor on renin secretion were examined in anesthetized dogs with either a single filtering kidney or a single denervated nonfiltering kidney. (biomedsearch.com)
  • Four-hour infusions of synthetic atrial natriuretic peptide in normal volunteers. (biomedsearch.com)
  • Brefeldin A defines distinct pathways for atrial natriuretic factor secretion in neonatal rat atrial and ventricular myocytes. (semanticscholar.org)
  • The basic helix-loop-helix transcriptional repressor Hairy-related transcription factor 2 (Hrt2) is expressed in ventricular, but not atrial, cardiomyocytes, and in endothelial and vascular smooth muscle cells. (pnas.org)
  • Release of atriopeptin in the rat by vasoconstrictors or water immersion correlates with changes in right atrial pressure. (springer.com)
  • The potency of the atrial natriuretic factor fragments in the radioligand assay was in proportion to their potency to inhibit aldosterone secretion by isolated rat glomerulosa cells. (ahajournals.org)
  • We evaluated 1575 non-hypertensive Framingham Offspring cohort participants (mean age 55±9 years, 58% women) who underwent routine measurements of circulating aldosterone and N-terminal proatrial natriuretic peptide (NT-ANP) and assessment of dietary sodium intake. (pubmedcentralcanada.ca)
  • The cosecretional maturation of atrial natriuretic factor by primary atrial myocytes. (semanticscholar.org)
  • Acid prohormone sequence determines size, shape, and docking of secretory vesicles in atrial myocytes. (semanticscholar.org)
  • 18 19 20 21 22 However, the role of the natriuretic peptide family on SMC migration remains to be clarified. (ahajournals.org)
  • They include agents like vascular endothelial growth factor (VEGF) and blood vessel fibroblastic growth factor (bFGF). (thefreedictionary.com)
  • Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. (nii.ac.jp)
  • The dose-response curves of forearm blood flow and of forearm vascular resistance after increasing infusion rates of atrial natriuretic factor were shifted to the right in the elderly when compared with the young subjects. (ahajournals.org)
  • 3. No significant effect was observed on specific airway conductance at any rate of infusion despite maximum mean (sem) plasma levels of 597 (62) pg of atrial natriuretic factor/ml in peripheral venous blood. (portlandpress.com)
  • The effect of a 20-min infusion of atrial natriuretic factor (ANF) 99-126, 0.4 jxg/kg per min, on both urinary albumin and [beta];2-microglobulin excretion was examined in nine normal male subjects during stable water diuresis. (gla.ac.uk)
  • To evaluate the role of calcium in volume-induced secretion of atrial natriuretic factor (ANF), effects of verapamil and endothelin-1 (ET-1), both known to influence free intracellular calcium, were studied during saline infusion in seven conscious instrumented dogs. (uclouvain.be)
  • Examines the release of atrial natriuretic factor after pericardiocentesis for malignant pericardial infusion. (ebscohost.com)
  • Sensitivity" to salt, characterized by a pressor BP response with greater intake of dietary salt (sodium chloride), has been identified as an important contributing factor to the development of high BP in some individuals. (pubmedcentralcanada.ca)
  • In the three experiments, heart rate and left atrial pressure (LAP) increased (P less than 0.001) similarly. (uclouvain.be)
  • Estimation of mean left atrial pressure from transesophageal pulsed Doppler echocardiography of pulmonary venous flow. (ahajournals.org)
  • Vodovar N, Mebazaa A, Januzzi JL, Murtagh G, Stough WG, Adams KF, Zannad F. Evolution of natriuretic peptide biomarkers in heart failure: Implications for clinical care and clinical trials. (harvard.edu)
  • Observations in vitro and in heart failure patients suggest that atrial natriuretic peptide. (ebscohost.com)
  • Background Elevated B‐type natriuretic peptide ( BNP ) levels are associated with heart failure and increased mortality in the general population. (ahajournals.org)
  • Díez J. Chronic heart failure as a state of reduced effectiveness of the natriuretic peptide system: implications for therapy. (springer.com)
  • Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP). (semanticscholar.org)
  • Synthesis of atrial natriuretic polypeptide in human failing hearts. (nii.ac.jp)
  • Prevalence of Cardiovascular Disease and Its Risk Factors in Primary Aldosteronism: A Multicenter Study in Japan. (medscape.com)
  • The discovery of a natriuretic factor (one that promotes kidney excretion of salt and water) was first reported by de Bold in 1981 when rat atrial extracts were found to contain a substance that increased salt and urine output in the kidney. (wikipedia.org)
  • O'Donnell, ME & Owen, NE 1986, ' Role of cyclic GMP in atrial natriuretic factor stimulation of Na + ,K + ,Cl - cotransport in vascular smooth muscle cells ', Journal of Biological Chemistry , vol. 261, no. 33, pp. 15461-15466. (elsevier.com)
  • Because natriuretic peptide levels reflect intravascular volume and pressure, it is hypothesized that when patients are prescribed medications that promote fluid retention-such as non-selective nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors-monitoring natriuretic peptide levels before and after initiating the medication may allow these medications to be used more safely. (jabfm.org)
  • These factors may also contribute to the regulation of ANP secretion. (springer.com)
  • N2 - *Atrial natriuretic factor (ANP) has shown over recent decades to play an emerging role in the regulation of coronary blood flow as well as systemic blood pressure. (muni.cz)
  • Atrial natriuretic peptide (ANP) is involved in the regulation of basal blood pressure,blood flow, and vascular tone. (nii.ac.jp)