A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.
Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.
Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.
Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.
A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release.
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.
Androstanes and androstane derivatives which are substituted in any position with one or more hydroxyl groups.
The synapse between a neuron and a muscle.
Drugs that interrupt transmission at the skeletal neuromuscular junction by causing sustained depolarization of the motor end plate. These agents are primarily used as adjuvants in surgical anesthesia to cause skeletal muscle relaxation.
Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.
The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.
Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.
A major nerve of the upper extremity. In humans, the fibers of the ulnar nerve originate in the lower cervical and upper thoracic spinal cord (usually C7 to T1), travel via the medial cord of the brachial plexus, and supply sensory and motor innervation to parts of the hand and forearm.
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
The period of emergence from general anesthesia, where different elements of consciousness return at different rates.
A mixture of isomeric tritolyl phosphates. Used in the sterilization of certain surgical instruments and in many industrial processes.
A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
The first digit on the radial side of the hand which in humans lies opposite the other four.
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.

Influence of atracurium on the diaphragm mean action potential conduction velocity in canines. (1/168)

BACKGROUND: It has been shown that progressive neuromuscular blockade (NMB) affects the electromyogram power spectrum and compound muscle action potential duration in skeletal muscle. These measures are linked to the mean muscle action potential conduction velocity (APCV), but no studies have confirmed a relation between the mean APCV and NMB. The aim of this study was to determine whether diaphragm mean APCV is affected by NMB. METHODS: The effects of NMB on diaphragm mean APCV were evaluated in five mongrel dogs. Progressive NMB was induced by slow intravenous infusion of atracurium. During spontaneous breathing, the diaphragm mean APCV was determined by electromyogram signals, in the time and frequency domains. The magnitude of NMB was quantified by the amplitude of the compound muscle action potential and by changes in muscle shortening during supramaximal stimulation of the phrenic nerve. RESULTS: Progressive NMB was associated with a decrease in diaphragm mean APCV. At approximately 70% reduction in the compound muscle action potential amplitude, diaphragm mean APCV had decreased more than 20%. Recovery after NMB was characterized by a restoration of the mean APCV to control values. CONCLUSION: This study shows that progressive NMB paralyzes motor units within the diaphragm in an orderly manner, and the blockade first affects muscle fibers with high APCV before it affects fibers with lower APCV.  (+info)

The infusion rate of mivacurium or atracurium for cesarean section compared with gynecological procedures. (2/168)

Mivacurium is mainly metabolized by plasma cholinesterase, whereas atracurium is removed by Hofman elimination. The purpose of this study was to compare the infusion rate of atracurium and mivacurium in maintaining surgical relaxation, and to compare their recovery indices between parturients and non-pregnant women. Muscle relaxation was maintained by the continuous infusion of relaxants to retain the first response of train-of-four (TOF) at 5% of control. When mivacurium was used, Bolus-T5 (duration from the end of mivacurium bolus injection to 5% single twitch recovery) was measured. After discontinuing the infusion, the recovery index was measured. The infusion rate of mivacurium, not atracurium, was significantly lower in parturients and Bolus-T5 of parturients was significantly longer than that of non-pregnant women. There was no significant difference in the recovery indices of both relaxants. The authors concluded that the infusion rate of mivacurium in maintaining muscle relaxation in parturients should be reduced compared to the rate in non-pregnant women and measuring Bolus-T5 may be helpful in determining the infusion rate to maintain muscle relaxation.  (+info)

Comparison of a new piezoelectric train-of-four neuromuscular monitor, the ParaGraph, and the Relaxometer mechanomyograph. (3/168)

The ParaGraph is a new device for monitoring neuromuscular function using a piezoelectric motion sensor. In 20 patients, monitoring of neuromuscular block produced by cisatracurium 0.1 mg kg-1 was compared using the ParaGraph and a Relaxometer 2 mechanomyograph. The ParaGraph was quick to set up, and easy to operate and interpret. There were no significant differences in the time to 100% depression of T1/T0, time to 25% recovery of T1/T0 or time to recovery of T1/T0 from 25% to 75%, measured by the two monitors. When the difference between the two monitors was plotted against the average of the two measurements, the limits of agreement for T1/T0 (-42.95, +53.98%) and the train-of-four ratio, T4/T1 (-0.28, +0.21) were too wide to allow the values given by the two monitors for individual patients to be used interchangeably.  (+info)

Cisatracurium neuromuscular block at the adductor pollicis and the laryngeal adductor muscles in humans. (4/168)

We have compared the dose-response relationship (n = 30) and time course of neuromuscular block (n = 20) of cisatracurium at the laryngeal adductor and the adductor pollicis muscles. ED95 values for cisatracurium were 66.8 (95% confidence interval 61.3-72.3) micrograms kg-1 at the larynx and 45.2 (42.1-48.3) micrograms kg-1 at the adductor pollicis muscle (P < 0.0001). After administration of cisatracurium 0.1 mg kg-1, onset time was 2.7 (2.2-3.2) min at the larynx and 3.9 (3.0-4.8) min at the adductor pollicis (P < 0.0001). Time to 95% recovery of the first twitch of the TOF was 26.9 (20.1-33.7) min and 45.6 (39.7-51.5) min, respectively (P < 0.0001). We found that the laryngeal adductors were more resistant to the action of cisatracurium than the adductor pollicis muscle, but onset and recovery were faster at the larynx.  (+info)

A comparison of continuous infusion of vecuronium and atracurium in midline and paramedian laparotomies. (5/168)

This was a study to compare continuous intravenous infusion of atracurium with continuous intravenous infusion of vecuronium for intraoperative muscle relaxation in 62 ASA I / II patients. Scheduled for laparotomies and pelvic surgeries under general anaesthesia. They were randomly allocated in two groups to receive either vecuronium infusion of 50 microg/kg/hour following a bolus dose of 0.1 microg/kg, or atracurium infusion of 400 microg/kg/hour following a bolus dose of 0.5 microg/kg. The mean infusion dose of atracurium was 478 +/- 44.11 microg/kg/hour and that of vecuronium was 63.2 +/- 74 microg/kg/hour for adequate muscle relaxation. The depth of neuromuscular blockade was monitored by using peripheral nerve stimulator so that only one twitch of train of four was present, resistance to ventilation, surgical relaxation and haemodynamic changes. Vecuronium infusions produced more haemodynamic stability than atracurium infusions. Vecuronium produced lesser change in systolic blood pressure (mean change of 3. 46 +/- 3.33%) from baseline values as compared to atracurium (mean change of 5.81 +/- 3.73%) from baseline values ( p < 0.01) which was statistically significant. The difference in mean pulse rate change from baseline value in the atracurium group (4.78 +/- 2.745%) was less than that in the vecuronium group (5.99 +/- 2.67%), which was not statistically significant. Spontaneous recovery was faster with vecuronium (540.94 +/- 76.46 seconds) as compared to atracurium (596. 33 +/- 72.48 seconds). 84.4% of patients who received vecuronium fell within good to very good category of muscle relaxation as compared to 63.3% in atracurium group. There were no cost benefits when either agents were used in infusion form.  (+info)

The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium. (6/168)

BACKGROUND: Residual neuromuscular block caused by vecuronium alters pharyngeal function and impairs airway protection. The primary objectives of this investigation were to radiographically evaluate the swallowing act and to record the incidence of and the mechanism behind pharyngeal dysfunction during partial neuromuscular block. The secondary objective was to evaluate the effect of atracurium on pharyngeal function. METHODS: Twenty healthy volunteers were studied while awake during liquid-contrast bolus swallowing. The incidence of pharyngeal dysfunction was studied by fluoroscopy. The initiation of the swallowing process, the pharyngeal coordination, and the bolus transit time were evaluated. Simultaneous manometry was used to document pressure changes at the tongue base, the pharyngeal constrictor muscles, and the upper esophageal sphincter. After control recordings, an intravenous infusion of atracurium was administered to obtain train-of-four ratios (T4/T1) of 0.60, 0.70, and 0.80, followed by recovery to a train-of-four ratio of more than 0.90. RESULTS: The incidence of pharyngeal dysfunction was 6% during the control recordings and increased (P < 0.05) to 28%, 17%, and 20% at train-of-four ratios 0.60, 0.70, and 0.80, respectively. After recovery to a train-of-four ratio of more than 0.90, the incidence was 13%. Pharyngeal dysfunction occurred in 74 of 444 swallows, the majority (80%) resulting in laryngeal penetration. The initiation of the swallowing reflex was impaired during partial paralysis (P = 0.0081). The pharyngeal coordination was impaired at train-of-four ratios of 0.60 and 0.70 (P < 0.01). A marked reduction in the upper esophageal sphincter resting tone was found, as well as a reduced contraction force in the pharyngeal constrictor muscles. The bolus transit time did not change significantly. CONCLUSION: Partial neuromuscular paralysis caused by atracurium is associated with a four- to fivefold increase in the incidence of misdirected swallowing. The mechanism behind the pharyngeal dysfunction is a delayed initiation of the swallowing reflex, impaired pharyngeal muscle function, and impaired coordination. The majority of misdirected swallows resulted in penetration of bolus to the larynx.  (+info)

Dose requirements of infusions of cisatracurium or rocuronium during hypothermic cardiopulmonary bypass. (7/168)

We investigated the influence of mild hypothermic cardiopulmonary bypass (CPB) on the dose requirements of cisatracurium or rocuronium used as a continuous infusion. We studied eight patients given cisatracurium and nine given rocuronium. They were ASA class III and IV and scheduled for elective coronary artery bypass grafting. Neuromuscular transmission was monitored electromyographically. After recovery of T1/T0 to 10%, a cisatracurium infusion or a rocuronium infusion was started at a rate of 1.5 or 10 micrograms kg-1 min-1, respectively, and adjusted to maintain T1/T0 at 15%. Infusion rate and duration were recorded before, during and after CPB in each patient and the mean infusion rates were calculated. One-way ANOVA showed a statistically significant difference between the cisatracurium infusion rates before, during and after CPB: A T1/T0 of 15% could be achieved with a mean infusion rate of 1.1, 0.75 and 0.98 micrograms kg-1 min-1 before, during and after CPB, respectively. There was no significant difference between the rocuronium infusion rates before, during and after CPB. The mean rocuronium infusion rate required to maintain T1/T0 at 15% throughout the procedure was 4.1 micrograms kg-1 min-1. Cisatracurium infusion rates should be halved during CPB. Even after CPB, requirements are reduced. The same tendency occurs with rocuronium, but the changes in infusion rate were not statistically significant.  (+info)

Preanesthetic train-of-four fade predicts the atracurium requirement of myasthenia gravis patients. (8/168)

BACKGROUND: The most sensitive diagnostic criterion of myasthenia gravis is a decrement in the muscular response to repetitive stimulation. The authors hypothesized that myasthenia gravis patients who show a train-of-four ratio (T4/T1) < 0.9 in the preanesthetic period will have increased sensitivity to nondepolarizing neuromuscular blocking agents compared with myasthenia gravis patients with preanesthetic T4/T1 > or = 0.9. METHODS: After institutional review board approval was obtained, 20 electrophysiologically documented myasthenia gravis patients were studied. Current pyridostigmine therapy was continued until the morning of surgery. Before induction of anesthesia, neuromuscular transmission was recorded from the hypothenar muscles using electromyography with train-of-four stimulation of the ulnar nerve. According to the T4/T1 ratio, patients were assigned to the "normal" group (T4/T1 > or = 0.9) or the "decrement" group (T4/T1 < 0.9). After induction of intravenous anesthesia, the effective dose to achieve a 95% neuromuscular blockade (ED95) for atracurium was assessed with a cumulative bolus technique. Postoperatively, pyridostigmine was titrated to obtain a T4/T1 > 0.75 and to treat residual myasthenic symptoms. RESULTS: In 14 patients, preanesthetic T4/T1 was > or = 0.9 (normal), whereas 6 patients presented with T4/T1 < 0.9 (decrement). Decrement patients had a lower ED95 of 0.07 +/- 0.03 mg/kg atracurium (mean +/- SD) compared with normal patients with an ED95 of 0.24 +/- 0.11 mg/kg atracurium (P = 0.002). All patients were extubated within 30 min after surgery. Postoperative pyridostigmine infusion did not differ significantly between groups. CONCLUSIONS: The requirement for atracurium is significantly reduced in myasthenia gravis patients with a T4/T1 ratio < 0.9 before anesthesia. This study indicates that routine neuromuscular monitoring in myasthenia gravis patients should be extended into the preinduction period to identify patients who require less atracurium.  (+info)

Dennis M. Fisher, P. Claver Canfell, Mark R. Fahey, Judith I. Rosen, Stephen M. Rupp, Lewls B. Sheiner, Ronald D. Miller; Elimination of Atracurium in Humans: Contribution of Hofmann Elimination and Ester Hydrolysis versus Organ-based Elimination. Anesthesiology 1986;65(1):6-12. Download citation file:. ...
Serious and fatal adverse reactions including gasping syndrome can occur in neonates and infants treated with benzyl alcohol-preserved drugs, including Cisatracurium Besylate Injection (10 mL multiple-dose vials). This warning is not applicable to the 5 mL and 20 mL Cisatracurium Besylate Injection single-dose vials because these vials do not contain benzyl alcohol. The gasping syndrome is characterized by central nervous system depression, metabolic acidosis, and gasping respirations.. When prescribing the 10 mL multiple-dose Cisatracurium Besylate Injection vials in infants consider the combined daily metabolic load of benzyl alcohol from all sources including Cisatracurium Besylate Injection (multiple-dose vials contain 9 mg of benzyl alcohol per mL) and other drugs containing benzyl alcohol. The minimum amount of benzyl alcohol at which serious adverse reactions may occur is not known [see Use in Specific Populations (8.4)].. The use of 10 mL Cisatracurium Besylate Injection ...
A prospective, randomized, double-blind study was performed in 40 patients (ASA class I-III) treated with atracurium to ascertain whether histamine release caused hemodynamic or cutaneous changes. The treated group of 20 patients was premedicated with the H1 antagonist dimetindene (0.2 mg/kg) and the H2 antagonist ranitidine (1.25 mg/kg); the control group of 20 patients received saline. Six minutes after the induction of anesthesia with thiopental/fentanyl, patients received atracurium 0.5 mg/kg over 5 s. Plasma histamine levels were measured fluorometrically 5 min after administration of thiopental/fentanyl and 2 and 5 min after atracurium. Arterial blood pressure and heart rate were recorded every 2 min. Histamine levels (0.24 ng/mL) did not change significantly after thiopental/fentanyl. In the control group, 2 min after injection of atracurium, plasma histamine levels were 0.76 +/- 0.76 ng/mL, and in the antihistamine-treated group, 0.39 +/- 0.24 ng/mL (P , 0.05 control versus treated), ...
The Hofmann rearrangement is the organic reaction of a primary amide to a primary amine with one fewer carbon atom. The reaction is named after its discoverer - August Wilhelm von Hofmann. This reaction is also sometimes called the Hofmann degradation, and should not be confused with the Hofmann elimination. The reaction of bromine with sodium hydroxide forms sodium hypobromite in situ, which transforms the primary amide into an intermediate isocyanate. The formation of an intermediate nitrene is not possible because it implies also the formation of an hydroxamic acid as a byproduct, which has never been observed. The intermediate isocyanate is hydrolyzed to a primary amine, giving off carbon dioxide. Base abstracts an acidic N-H proton, yielding an anion. The anion reacts with bromine in an α-substitution reaction to give an N-bromoamide. Base abstraction of the remaining amide proton gives a bromoamide anion. The bromoamide anion rearranges as the R group attached to the carbonyl carbon ...
Administration of atracurium in dogs undergoing laparoscopic ovariectomy with a standardised ventilation pattern did not result in clinically important differences in selected
Hofmann S, Everaars J, Schweiger O, Frenzel M, Bannehr L, Cord AF (2017) Modelling patterns of pollinator species richness and diversity using satellite image texture. PLOS ONE [https://doi.org/10.1371/journal.pone.0185591]. Zimmermann A, Knecht H, Haesler R, Zissel G, Gaede K, Hofmann S, Nebel A, Mueller-Quernheim J, Schreiber S, Fischer A (in press) Atopobium and Fusobacterium as novel candidates for sarcoidosis associated microbiota. European Respiratory Journal 50: 1600746 [doi: 10.1183/13993003.00746-2016]. Hofmann S, Stöck M, Zheng Y, Ficetola GF, Li J, Scheidt U, Schmidt J (2017) Molecular Phylogenies indicate a Paleo-Tibetan Origin of Himalayan Lazy Toads (Scutiger). Scientific Reports 7:3308; press release in Englisch, Deutsch and Koreanisch [https://doi:10.1038/s41598-017-03395-4].. Hofmann S, Fritzsche P, Miehe G (2016) First record of Elaphe dione from high altitude in Western Sichuan reveals high intraspecific differentiation. Salamandra 52:273-277.. Mohapatra P, Schulz KD, ...
Product Overview: Cisatracurium Besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration. Cisatracurium Besylate acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors ...
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A 7-month-old, 7-kg infant received 6 mg cisatracurium intravenously after induction of anesthesia with nitrous oxide and halothane. There was no change in heart rate, noninvasive blood pressure obtained with the cuff on the upper arm, or skin color, but when the surgery was concluded, neuromuscular block persisted to the extent that no posttetanic count could be elicited. The infant received midazolam and mechanical ventilation in the recovery room. One hundred minutes after the dose of 0.86 mg/kg cisatracurium, a very slight response of the adductor pollicis to stimulation of the ulnar nerve with 2 Hz, a train-of-four (TOF) every 60 s was documented by the Datex neuromuscular transmission monitor electromyogram in the uncalibrated mode. One hundred and ten minutes after the bolus of cisatracurium, four responses to the TOF were recorded. At this time, the patients diaphragm, fingers, and toes were moving spontaneously. Propofol was administered by infusion to produce immobility. During the ...
Find information on Atracurium (Tracrium) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Both overfeeding and underfeeding of intensive care unit (ICU) patients are associated with worse outcomes. A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomena. Several factors that influence EE have been studied previously. However, the effect of neuromuscular blocking agents on EE, which conceptually would lower EE, has not been extensively investigated. We studied a cohort of adult critically ill patients requiring invasive mechanical ventilation and treatment with continuous infusion of cisatracurium for at least 12 h. The study aimed to quantify the effect of cisatracurium infusion on EE (primary endpoint). EE was estimated based on ventilator-derived VCO2 (EE in kcal/day = VCO2 × 8.19). A subgroup analysis of septic and non-septic patients was performed. Furthermore, the effects of body temperature and sepsis on EE were evaluated. A secondary endpoint was hypercaloric feeding (| 110% of EE) after cisatracurium infusion. In total, 122 patients
I'm so excited to share this episode with George Hofmann. We talk more about George's book, Resilience: Handling Anxiety in a Time of Crisis, his personal story and the tools that have helped him manage his bipolar over the year. We explore the possible relationship between depression, anxiety and being a Highly Sensitive Person, along with the stigma often associated with mental illness. Finally, we touch upon the benefits, but also the difficulties that often come with mindfulness and meditation practises.More about George...George Hofmann has managed to overcome the worst of bipolar disorder by adding practices in focused attention to the usual therapies of medicine and talk. He works to show others with anxiety, depression and bipolar disorder how to do the same. George has conducted workshops on meditation, movement and meaningful work for individuals, families, support groups, churches, healthcare professionals and corporations. He is the author of the book Resilience: Handling
I Have Something to Tell You by Regan Hofmann - For ten years, Regan Hofmann lived a double life. To the world, she was a woman from Princeton who went to prep...
Professional guide for Cisatracurium Besylate. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Cisatracurium Besylate reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).
Intraoperative Course. I. Monitoring requirements. 1. What electrocardiogram leads will you monitor? Explain.. 2. Could the Dinamap, pulse oximetry, and end-tidal CO2 take the place of an arterial catheter?. 3. If an arterial catheter is used, are pulse oximetry and end-tidal oximetry necessary?. II. Choices and management of anesthesia. 1. Would you use etomidate for induction? Explain.. 2. What is your choice for induction? Explain your rationale.. 3. What steps will you take to prevent the hypertensive response to laryngoscopy and intubation?. 4. Why is this important?. 5. Would halothane be a good choice for maintenance? Explain.. 6. Is narcotic only anesthesia preferred? Explain.. 7. Compare the circulatory effects of these drugs.. 8. Relate these choices to postoperative planning.. III. Management of muscle relaxation. 1. Would an atracurium infusion be your choice?. 2. What would determine dose requirements?. 3. How will you monitor effect?. 4. When will you reverse paralysis, and how ...
View Untitled by Hans Hofmann sold at Abstract by Nature: Paintings from the 1950s to the Present on . Learn more about the piece and artist, and its final selling price.
Hofmann, W., Baumert, A., & Schmitt, M. (2005). Heute haben wir Hitler im Kino gesehen: Evaluation der Wirkung des Films der Untergang auf Schüler und Schülerinnen der neunten und zehnten Klasse [Today we saw Hitler at the cinema: Evaluation of the effects of the film Der Untergang (downfall) on ninth and tenth grade students]. Zeitschrift für Medienpsychologie, 17, 132-146. doi:10.1026/1617-6383.17.4.132 ...
Hofmann, W., Baumert, A., & Schmitt, M. (2005). Heute haben wir Hitler im Kino gesehen: Evaluation der Wirkung des Films der Untergang auf Schüler und Schülerinnen der neunten und zehnten Klasse [Today we saw Hitler at the cinema: Evaluation of the effects of the film Der Untergang (downfall) on ninth and tenth grade students]. Zeitschrift für Medienpsychologie, 17, 132-146. doi:10.1026/1617-6383.17.4.132 ...
Dr. Hofmann first synthesized the compound in 1938, while researching ergot derivatives as a chemist for Sandoz Pharmaceuticals in Basel. The substance was tested on lab animals with no interesting results, so like hundreds of ...
Chimera, 1959, Reproduction Oil Painting original hand painted by Hans Hofmann. Affordable art for anyone - Museum Quality - FREE Shipping.
Unveiled at Autopromotec 2015 - Bologna - the renewed series geodyna wheel balancers Hofmann, with touchscreen monitor and automatic non-contact data entry.. ...
This study investigated optimal dose of combination of Rocuronium and Cisatracurium through monitoring neuromuscular relaxation during surgery.
Artacil 100mg/ml Injection is used in the treatment of Skeletal muscle relaxation during surgery. View Artacil 100mg/ml Injection uses, composition, side-effects, price, substitutes, drug interactions, precautions, warnings, expert advice and buy online at best price on 365chemist.com
Our custom labels are of the highest quality - clear, crisp and easy to read. They come in a range of colours and sizes, and are produced to meet the demands of harsh environments or temperature extremes.
Thesis, English, Comparison of Kinemyography with Electromyography Neuromuscular Monitoring in Pediatric Patients Receiving Cisatracurium or Rocuronium during General Anesthesia for Abdel Aziz Mohammed Abdel Rahmn
Find information on Cisatracurium (Nimbex) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Meine wissenschaftlichen Publikationen findest Du hier: https://www.ncbi.nlm.nih.gov/pubmed/?term=sachse-seeboth+c. 1. Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters. Matthaei J, Tzvetkov MV, Gal V, Sachse-Seeboth C, Sehrt D, Hjelmborg JB, Hofmann U, Schwab M, Kerb R, Brockmöller J. Genome Med. 2016 Nov 8;8(1):119.. 2. Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2. Matthaei J, Tzvetkov MV, Strube J, Sehrt D, Sachse-Seeboth C, Hjelmborg JB, Möller S, Halekoh U, Hofmann U, Schwab M, Kerb R, Brockmöller J. Clin Pharmacol Ther. 2016 Dec;100(6):606-616. doi: 10.1002/cpt.444. Epub 2016 Sep 23.. 3. Heritability of metoprolol and torsemide pharmacokinetics. Matthaei J, Brockmöller J, Tzvetkov MV, Sehrt D, Sachse-Seeboth C, Hjelmborg JB, Möller S, Halekoh U, Hofmann U, Schwab M, ...
The herbs boosted her milk production to a couple of ounces per day. Hofmann froze her milk in the hope that shed be able to share it with a baby some day.. After four months, Hofmann added domperidome to her daily routine of pumping and herbs. This medication has long been used to treat stomach disorders but had the side effect of causing lactation. After adding domperidome, Hofmanns milk production ballooned to upwards of 10 ounces per day.. The only thing that is missing when you induce lactation is that you dont get the colostrum in the first couple of days. Other than that, my breast milk is the same as anyone else that has given birth, Hofmann said. ...
The papers of painter, teacher, and writer Hans Hofmann measure 29.92 linear feet and 5.00 GB and date from circa 1904 to 2011, with the bulk of the materials dating from 1945 to 2000. The majority of the papers were created after 1932 and document Hofmanns life and professional career after settling in the United States. Among his papers are personal and professional correspondence; records of his schools in Munich, New York City, and Provincetown, Mass.; writings and notes; financial records; photographs; printed matter; estate records; and a small number of personal papers of his second wife, Renate Schmitz Hofmann. Hofmanns personal papers are augmented by a large selection of printed matter, including exhibition catalogs, articles, news clippings, and monographs about Hofmann and modern art, as well as documentary projects including Tina Dickeys compilation of oral histories and records of Hofmanns students, and research materials, sound and video recordings, digital material, and ...
In Reply:-We thank Drs. Donati and Plaud for pointing out the error in Figure 2in our published study. [1] Unfortunately, this calculation error not only escaped our attention, but also the attention of the reviewers. However, this error does not change our conclusions. The isobolographic analysis still demonstrates a synergistic interaction with respect to the neuromuscular blocking activity of the rocuronium and cisatracurium combination (Figure 1). The experimentally determined ED50(and 95% confidence interval) for the combination was 36.8 (35-38)[micro sign]g/kg for rocuronium and 8.7 (8.3-9.1)[micro sign]g/kg for cisatracurium. The theoretic additive ED50(and 95% confidence interval) was calculated to be 55.5 (53.3-57.7)[micro sign]g/kg for rocuronium and 13.1 (12.6-13.6)[micro sign]g/kg for cisatracurium. The confidence intervals of these points do not overlap, and the results of a Student t test for potency ratio were significant (P , 0.001), indicating synergism. The fractional ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
April 19, 1943, Hoffmann performed a self-experiment to determine the true effects of LSD, intentionally ingesting 0.25 milligrams (250 micrograms) of the substance, an amount he predicted to be a threshold dose (an actual threshold dose is 20 micrograms).[7] Less than an hour later, Hofmann experienced sudden and intense changes in perception. He asked his laboratory assistant to escort him home and, as use of motor vehicles was prohibited because of wartime restrictions, they had to make the journey on a bicycle. On the way, Hoffmans condition rapidly deteriorated as he struggled with feelings of anxiety, alternating in his beliefs that the next-door neighbor was a malevolent witch, that he was going insane, and that the LSD had poisoned him. When the house doctor arrived, however, he could detect no physical abnormalities, save for a pair of incredibly dilated pupils. Hofmann was reassured, and soon his terror began to give way to a sense of good fortune and enjoyment, as he later wrote... ...
Entry level: Reliable command of morphology and syntax to the extent taught in Rubenbauer / Hofmann (H. Rubenbauer / J. B. Hofmann / R. Heine, Lateinische Grammatik, Bamberg and München, any edition). Extensive vocabulary (R. Vischer, Lateinische Wortkunde, Stuttgart, any edtion: all words marked by a triangle, a black dot or numbers 1-4). ...
Dr. Jonathan Reiner, Cheneys cardiologist, asked Dr. Lewis Hofmann, Cheneys White House physician, to arrange for the potassium test to be repeated tonight (see (Late Afternoon) September 11, 2001). Consequently, while he is accompanying Cheney as the vice president is being flown by helicopter to Camp David (see Shortly After 10:00 p.m. September 11, 2001), Hofmann passes Cheney a note, informing him that he needs to provide another sample of blood. Cheney, though, refuses to do so. Not tonight, Lew, you can have it in the morning, he says. Whether he is aware of the results of the test on his blood sample from this morning and the possible danger he is in are unstated ...
There are currents of influence on the contemporary art scene so pervasive that, in retrospect, they seem to define an entire era. For a good many artists and critics who came of age in the heyday of the Abstract Expressionist movement in the 1940s and 1950s, the principal influences were those of...
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Lukas Hofmann: Bio. Download PDF Portfolio here.. [email protected] In the course of collecting some information to write this bio, we let out one of the Black beauty stick insects, Peruphasma schultei. Pinny legs, one by one, up his Kenzo sweater, juice-pink vestigial wings. As if to propose an axiom to start speaking about the work again, he says, It looks so nice on the sweater. But we could always say that - this sweater looks nice on you or you look nice on that sweater.. Although Hofmann {*93} works mainly in the field of performance, his artistic practice reaches out to various other fields and media: he relates to the artistic milieu as well as the world of fashion, where he is occasionally active as a stylist and model, and he is also busy as a curator.. As an artist who grew up in Prague during the 90s and who is now staging performances across the countries of an increasingly unstable European Union, contingency and informality are reoccurring elements in the narrative of ...
The Horse is a beautiful book that gets right to the heart of these stunning animals, exploring everything from their behavior within a herd, to the myths and legends we associate with them, and their striking physicality. It concludes with sections on their varied colors and markings, and a charming chapter on their : Parragon, Incorporated.
davical_https is a Docker image for a DAViCal server based on Debian 10 (davical, awl, php, apache, postgresql, perl). DAViCal is a server for shared calendars implementing the CalDAV protocol. The calendars are stored in the iCalendar format ...
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Thanks & regards, Avinash Joshi On 1/31/08, Frank.Hofmann at sun.com ,Frank.Hofmann at sun.com, wrote: , On Thu, 31 Jan 2008, Antonello Cruz wrote: , , , James Carlson wrote: , ,, Seeing those submitters go to the relevant community or project , ,, mailing list with a proposed patch (or better yet a pointer to a , ,, webrev) would be greatly preferred, and if we can gently guide them , ,, there when they mistakenly post changes here, thatd be good. , , Quick question: Do the contributors have access to the tools to generate , , webrevs? , , If youve got a full opensolaris source tree, youll find it in: , , usr/src/tools/scripts/webrev.sh , , FrankH. , _______________________________________________ , request-sponsor mailing list , request-sponsor at opensolaris.org , -- Sent from Gmail for mobile , mobile.google.com Thanks & Regards, Avinash Joshi AM106IT015 Department of Information Technology Amrita School of Engineering Amrita Vishwa Vidyapeetham Amritapuri Campus Clappana P.O., Kollam 690 ...
If there is anything funnier than the tight-fisted and terminally ungallant Brecht, it is surely the fuming, violently aroused Fuegi, remorselessly tracking the couple through an evening: but one should ask oneself if it would have made the blindest bit of difference to his curmudgeonliness if Bies skirts had been looser, the champagne had been cold. Brecht had urbanely tipped the waiter and the two had had it away at her aunts. The answer, obviously, is no. Always first there is Fuegis rancour.. Fuegis besetting rage at Brecht regularly leads him into inconsistency. All his leitmotifs - money, for instance - are stunningly badly handled. Another obsession is with Brechts wardrobe and particularly his spectacles, but I defy any reader to say whether it is because they are cheap or expensive or cheap-looking. He simply has it in for Brecht, and it shows: If he had made a lot of money from Threepenny, it did not look to her as if he had invested any of it into clothes: his suit was shabby, ...
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Cleanliness is one the biggest draws of living with cats. So, if you start to detect a bad odor from your cat, you need to take notice. In most cases, foul feline smells are a sign that something is seriously wrong. ...
This book offers a comprehensive survey of basic elements of nuclear dynamics at low energies and discusses similarities to mesoscopic systems. It addresses systems with finite excitations of their internal degrees of freedom, so that their collective motion exhibits features typical for transport processes in small and isolated systems.
Professor for Protein Crystallography, Ruhr-University Bochum - Geciteerd door 4.105 - Structural Biology - Biophysics - Protein Biochemistry - Photosynthesis
OBJECTIVES. The objectives of this study were the evaluation of the intraoperatory analgesia of remifentanil in dogs, comparing with fentanyl and a placebo solution, and the study of the hemodynamic and respiratory response and the patient recovery after two hours of anesthesia.. MATERIALS. Seven beagles dogs ASA I were anesthetized three times. All dogs were anaesthetized with medetomidine (10 mcg/kg IV), propofol (3 mg/kg IV, sevoflurane and atracurium (150 mcg/kg IV every 30 minutes. Three different analgesic protocols were evaluated: RMF: (remifentanil: 0,5 mcg/kg IV + 0,25 mcg/kg/min. FEN (2 mcg/kg IV + 0,1 mcg/kg/min IV). PCB (glucosade fluid infusion). In all cases the following postanesthetic analgesic protocol was used: morphine (0,2 mg/kg IM) and meloxicam (0,2 mg/kg IV) 20 minutes before the end of the procedure. Several cardiovascular and respiratory variables were studied every 5 minutes. Pain response was observed evaluated with a pinch with a forceps in the back paws. Recovery ...
Literature References: Prepn: Hofmann, Ber. 10, 213 (1877); Maximoff, US 2053095 (1935 to Azodal Co.). Prepn of salt: DE 562392 (1933 to Chem.-Pharm. Fabrik Hubold & Bartsch). See also Colour Index vol. 4 (3rd ed., 1971) p 4019; H. J. Conns Biological Stains, R. D. Lillie, Ed. (Williams & Wilkins, Baltimore, 9th ed., 1977) p 87. ...
Purpose: To compare the laryngeal mask airway (LMA) insertion conditions produced by propofol and a thiopental - low dose atracurium combination. Methods: In a randomized controlled double blind study, 120 premedicated patients were allocated into four groups. After pre-oxygenation, anesthesia was induced as follows: 1 μg · kg-1 fentanyl, 2.5 mg · kg-1 propofol (group I); 1 μg · kg-1 fentanyl, 5 mg · kg-1 thiopental (group II); 1 μg · kg-1 fentanyl, 5 mg · kg-1 thiopental, 0,05 mg · kg-1 or 0.1 mg · kg-1 atracurium (groups III and IV respectively). The LMA was inserted by a blinded anesthesiologist who also assessed the following insertion conditions on a three point scale; jaw relaxation, biting, gagging, coughing, presence of laryngospasm, adequacy of airway patency, number of attempts at insertion and overall insertion conditions. Results: There was no difference in insertion conditions between groups I, III and IV. Group II produced the worst overall conditions (P , 0.05). There ...
en] We studied the effects of intravenous ephedrine on the onset time and the intubating conditions 2 min after a bolus dose of cisatracurium (0.15 mg kg-1). Thirty patients anaesthetized with sufentanil and propofol were randomly divided in 2 groups to receive either ephedrine (70 micrograms.kg-1) or saline, 5 s before propofol. Cisatracurium was administered after loss of consciousness. Neuromuscular block was assessed at the adductor pollicis using accelography. Tracheal intubation was performed 2 min after cisatracurium injection and rated as excellent, good, poor or bad. At intubation, neuromuscular block (% height of control T1) was greater in patients receiving ephedrine (36.1 +/- 25.8% vs 57.9 +/- 25.1%) (mean +/- SD). The frequency of excellent intubating conditions was higher after ephedrine (86.6%) than after saline (40.0%). The onset time of cisatracurium was shorter after ephedrine (167 +/- 64.8 s vs 234.9 +/- 63.1 s). Thus, a low dose of ephedrine given before induction of ...
Background: Given the importance of the effect of muscle relaxants on the extubation time in coronary artery bypass grafting (CABG) patients, we sought to assess the difference in time to extubation and intensive care unit (ICU) length of stay between the primary bolus doses of Pancuronium and Cisatracurium without using the maintenance dose of them during surgery.Methods: This double blind clinical trial divided 110 patients into two equal groups receiving either Cisatracurium or Pancuronium. The patients surgical and cardiopulmonary bypass variables were evaluated, and the extubation time and ICU length of stay were compared between the two groups.Results: There was no difference between the two groups regarding the depth of anesthesia, train-offour (TOF) scores at the beginning of anesthesia, and the surgical and cardiopulmonary bypass variables. However, the Cisatracurium patients were extubated earlier and had a shorter ICU length of stay than the Pancuronium patients.Conclusion: An
Dr. R. Jeffrey Hofmann, a board certified ophthalmologist, specializes in ophthalmic plastic and reconstructive surgery including laser and cosmetic surgery. He has been a fellow of the American Society of Ophthalmic Plastic and Reconstructive Surgery since 1987 (see www.ASOPRS.org). Dr. Hofmann is a full-time staff member at Rhode Island Hospital, Miriam Hospital, and Hasbro Childrens Hospital, as well as Director of the Oculoplastic Surgery Clinic at the Veterans Administration Hospital in Providence. He is a Clinical Assistant Professor of Surgery at Browns Warren Alpert School of Medicine at Brown University and teaches medical students and residents.. Dr. Hofmann graduated summa cum laude from Tulane University, and went on to receive his medical degree with distinction - Alpha Omega Alpha - from Tulane University School of Medicine. He interned at Barnes Hospital in St. Louis, MO, and completed his residency in Ophthalmology at Washington University in St. Louis. He then pursued ...
In this provocative collection of short stories, Karen Hofmann creates characters who struggle to connect or disconnect from entanglements and relationships. With ironic accuracy and sensuous imagery, Hofmann considers a range of human foibles: a newlywed couple who transform into feral beasts during the hardships of a remote research expedition; backbiting faculty members who strip down during a post-conference BBQ; an heretical nun who explores the possibility of a new life by imaginatively excavating the fossils of BCs Burgess Shale; and an ambitious bylaw officer determined to make her mark on the citys streets.. In Echolocation, Karen Hofmann has found new ways to sound the depths of the human heart ...
THE man who synthesised LSD and became the first person to ever have an acid trip has died at the age of 102.. Swiss scientist Albert Hofmann died of a heart attack at his home in Basel yesterday, a friend and colleague said.. Dr Hofmann was working as a chemist in Basel when he synthesised lysergic acid diethylamide.. On April 19, 1943, he took the substance before cycling home. That day has become known among aficionados as Bicycle Day as it was while he was riding home that he experienced the most intense symptoms brought on by the drug. Dr Hofmann was also the first person to synthesise psilocybin, the active constituent of magic mushrooms. He also discovered the hallucinogenic principles of Ololiuqui (Morning Glory), lysergic acid amide and lysergic acid hydroxyethylamide. He disapproved of the appropriation of LSD by the youth movements of the 1960s, but regretted that its potential uses had not been explored ...
Artacil (50 mg) 10mg/1ml - 5ml Injection (Atracurium) drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. It is manufactured by Neon Laboratories Limited.
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Intraoperative Course. I. Selection of monitoring. 1. How will you assess the adequacy of renal perfusion during surgery? Explain.. 2. Is a pulmonary artery catheter necessary? Explain.. 3. After placement of a pulmonary artery catheter, pulmonary artery pressure is 55/32 mmHg, and the pulmonary artery occlusion pressure is 28 mmHg. What is your interpretation?. 4. Would you want additional information? Explain.. 5. What is your treatment?. II. Choice of anesthetic agents. 1. Is ketamine appropriate for induction? Explain.. 2. What is your choice for induction? Explain.. 3. What is your choice for maintenance? Give reasons.. 4. How do you control hypertension at the time of clamping?. 5. Does heart failure or renal insufficiency affect your selection of agents? Explain.. III. Management of muscle relaxation. 1. Is atracurium an appropriate muscle relaxant in this patient? Explain.. No. Atracurium is intermediate-acting, and is not significantly metabolized by the kidneys or the liver, as it is ...
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In chemistry, you dont solve things like that; you just recall the right class of reactions (Hofmann elimination in this case) and apply that knowledge. You can hardly expect to rediscover that from the first principles. Knowledge about other classes of organic compounds and their behavior in the presence of a base is not particularly helpful either. It is not until much later that those seemingly random pieces of data start to fit into a bigger picture.. As for the mechanism, it is all there in your second picture. Indeed, that $\ce{OH-}$ would readily snatch a proton from an ammonium cation $\ce{NH4+}$, only there is no ammonium, it is a substituted ammonium, and we dont have any H linked directly to N. So we go for the next best thing and grab a proton from some carbon in $\beta$ position, simultaneously with the formation of a double bond.. Note the reversed regiochemical preferences as compared to Zaitsev-type elimination, which has a different mechanism, usually involving the appearance ...
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General anesthesia is a drug-induced reversible state where neuromuscular blockade (NMB), hypnosis, and analgesia (jointly denoted by depth of anesthesia - DoA) are guaranteed. This thesis concerns mathematical modeling and feedback control of the effect of the muscle relaxants atracurium and rocuronium, the hypnotic propofol, and the analgesic remifentanil. It is motivated by the need to reduce incidences of awareness and overdose-related post-operative complications that occur in standard clinical practice. A major challenge for identification in closed-loop is the poor excitation provided by the feedback signal. This applies to the case of drugs administered in closed-loop. As a result, the standard models for the effect of anesthetics appear to be over-parameterized. This deteriorates the result of system identification and prevents individualized control.. In the first part of the thesis, minimally parameterized models for the single-input single-output NMB and the multiple-input ...
SEATTLE (AP) - Though Genette Hofmann is still using her brain, last month she donated a bit of it - to science.Hofmann needed the surgery - her Seattle surgeon was looking deep into her brain, where he found the trigger for the epileptic seizures that had disrupted her life for 30 years. But to get there, he teased out a bit of healthy tissue the size of a lima bean, and with her blessing quickly sent it to some researchers, who were eager to study brain cells while they were still alive.Thats how Hofmann joined a long line of epilepsy patients whove helped scientists reveal basic secrets of the brain - knowledge that could pay off in better ways to measure consciousness in brain-injury patients and new treatme
So how do you measure stress in a sea urchin? Stress in a cold-blooded, living-in-the-ocean kind of organism is something that threatens its physiological integrity, Hofmann explains. It messes up the way that it works. To understand exactly how stressful low pHs levels can be, she asks a number of questions of her tanks full of sea urchin larvae, whose developing skeletons are visible under a microscope: How are you doing in there? Are you building your skeleton? Are you making your body? And as she asks those questions, she also wants to know the costs: Are you having to use more of your energy to develop because its hard to deal with these low pHs? To find out, Hofmann photographs them under a microscope and measures their skeletons.. What we find, Hofmann explains, is that the larvae that develop in low pH or high CO2 as compared to standard conditions tend to be smaller at any given time. The CO2 causes a developmental delay. We cant quite tell if theyre going to be smaller ...
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Dave Grohl was really easy to talk to and I liked hanging out in the studio with him, I got to play on a track on their record and Pat Smear their guitarist gave me a ...
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Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Atomic scale defects are central to the mechanical, physical and failure properties of almost all structural alloys. These defects may, for example, be introduced by mechanical deformation, chemical changes or irradiation.. Felix is interested in characterising these defects and understanding the dramatic changes to material behaviour they may cause. To probe their structure and properties he uses a wide range of experimental techniques, concentrating in particular on X-ray diffraction. The short wavelength of X-rays, similar to the distance between atoms in many metals, makes them ideal for probing crystal lattice defects.. These experiments are combined with models that cover a wide range of length scales, from considering single atoms to macroscopic components. Two main topics he is currently working on are armour materials for future fusion reactors, and focussed ion beam machining for the manufacture of micro-mechanical systems.. ...
PubMed comprises more than 27 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
D.A. Bardwell, C.S. Adjiman, Y.A. Arnautova, E. Bartashevich, S.X.M. Boerrigter, D.E. Braun, A.J. Cruz-Cabeza, G.M. Day, R.G. Della Valle, G.R. Desiraju, B.P. van Eijck, J.C. Facelli, M.B. Ferraro, D. Grillo, M. Habgood, D.W.M. Hofmann, F. Hofmann, K.V.J. Jose, P.G. Karamertzanis, A.V. Kazantsev, J. Kendrick, L.N. Kuleshova, F.J.J. Leusen, A.V. Maleev, A.J. Misquitta, S. Mohamed, R.J. Needs, M.A. Neumann, D. Nikylov, A.M. Orendt, R. Pal, C.C. Pantelides, C.J. Pickard, L.S. Price, S.L. Price, H.A. Scheraga, J. van de Streek, T.S. Thakur, S. Tiwari, E. Venuti, I.K. ...
But I wouldnt mess mixing in another unknown (ethanol) into the already messy Hoffmann rearrangement reaction of phthalimide. This is why I wrote that Id aim for nice, clean isatoic anhydride from the rearrangement. (It is a useful compound in itself.) Then, in a second step Id have the anhydride react with the methanol (or ethanol). This step is really high-yielding and clean, yield is reportedly around 90% with MeOH, somewhat lower with EtOH - if my memory is right. ...
The stunning new building at St. Michael, which is at least 10 times the size of the old building, is a musicians dream: traditional cruciform plan, all hard surfaces (no carpet), organ and choir high at the west end of the nave. Our work involved moving the parishs old organ to the new building, separating the pipes into two sections to fit around the new window, building new enclosures and oak casework, rebuilding the console to conform more closely to AGO standards, adding several ranks of pipes, and rescaling and revoicing the old pipes to suit the new location and acoustics.. Traditions and experience have their own value. The organ in St. Michaels old building, by Herman Boettcher & Sons, showed the same fine attention to woodworking detail, use of quality new components, and clever and economical reuse of old material as some of the organs of Otto Hofmann, one of my mentors and models. Mr. Hofmann, a peer of Mr. Boettcher and a founding member and past president of the International ...
Environmental psychologist, interested in how the (built and natural) environment affects human behaviour and wellbeing, and in the design and evaluation of public participation in urban planning.
Interestingly enough, I was thinking about Hofmann a few days ago when I was biking through my beautiful neighborhood, taking in the glory of all the floral colors and every shade of green. I laughed to myself that it was like I was celebrating centenarian Hofmann -- who was still living the last I had read -- by reenacting Bicycle Day. I made a mental note to follow up on him later, though I forgot. As it turns out, that happened to be the day he died ...
I suppose what I was afraid of was that the sleek monumentality of such a book as a Collected Poems would somehow countermand and extinguish the scrappiness, the impurity, the profane improvisatoriness (the wax flowers, the trick with the river, the medias res of the embalmed corpse) of what seems to me Lowells greatest and most living work. That the fascinating equivocation between process and product, between hard and soft, would be upset. That this particular open book, so long in the making, would no longer provide the insect with any sort of bearable habitat.. The Collected Poems is a large and handsome production, especially where the page layout is concerned. Its pale Cambridge blue jacket is rather unexpected, and the Life Studies-era photograph of a slightly worried-looking Lowell in preppy clothes - collar and tie and sleeveless sweater - twisted half-upright in what looks like a deckchair, against a background of slumped books on shelves, sends the wrong message to, as it were, a ...
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... atracurium. Atracurium itself was invented at Strathclyde University and licensed to Burroughs Wellcome Co., Research Triangle ... To address this issue, a program was initiated to investigate the individual isomer constituents of atracurium to identify and ... Stiller RL, Cook DR, Chakravorti S (1985). "In vitro degradation of atracurium in human plasma". Br J Anaesth. 57 (11): 1085- ... now part of GlaxoSmithKline) by combining the name "atracurium" with "cis" [hence cisatracurium] because the molecule is one of ...
Fodale V, Santamaria LB (July 2002). "Laudanosine, an atracurium and cisatracurium metabolite". Eur J Anaesthesiol. 19 (7): 466 ... Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite of atracurium and cisatracurium. Laudanosine decreases ... to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium. ...
The orientation of the two O atoms in the bridge is to the THIQ side of the carbonyl C=O group, whereas in atracurium the O ... Unlike the potency of the cis-cis isomer of atracurium (also known as 51W89 and eventually produced as the drug cisatracurium ... Atracurium's groups are "reversed ester" linkages. This makes ester hydrolysis degradation by plasma cholinesterase more ... Having ten methoxy -OCH3 groups, mivacurium is a more potent neuromuscular blocking drug than atracurium (which has eight), but ...
Scientists later developed atracurium, vecurnoium, rocuronium, suxamethonium and pancuronium. Gallamine triethiodide is ... atracurium and cisatracurium. The choice among these NMBA depends on availability, cost and patient parameters that affect drug ...
... may increase the neuromuscular blocking activities of atracurium besilate. "chlortetracycline , C22H23ClN2O8 ...
"Anaphylaxis Is More Common with Rocuronium and Succinylcholine than with Atracurium". Anesthesiology. 122 (1): 39-45. doi: ...
"Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium". Anesth Analg. 80 (5): ...
... and Heart Rate after Rapid Paralysis with Atracurium in Cats". Can Anaesth Soc J. 32 (6): 618-621. doi:10.1007/BF03011408. PMID ...
Thus if full sedation alone is ineffective, people may be paralyzed with drugs such as atracurium. Paralysis allows the ...
The nondepolarizing muscle relaxants pancuronium, cisatracurium, atracurium, mivacurium, vecuronium and rocuronium also do not ...
Benzylisoquinolines, such as atracurium and tubocurarine, the other major group of neuromuscular blocking agents Ted Lin; Tim ...
Mouw RJ, Klumper F, Hermans J, Brandenburg HC, Kanhai HH (1999). "Effect of atracurium or pancuronium on the anemic fetus ...
Anaphylaxis Non-depolarizing muscle relaxants Histamine release e.g. Atracurium and Mivacurium Anaphylaxis Another potentially ... Decamethonium Non-depolarizing muscle relaxants Short acting Mivacurium Rapacuronium Intermediate acting Atracurium ...
Agonists are gyrase inhibitors like ciprofloxacin and non-depolarizing neuromuscular blocking agents like atracurium as well as ...
Cis-atracurium is very similar to atracurium except it is more potent and has a weaker tendency to cause histamine release. ... Mivacurium, atracurium, and doxacurium have greater N-N distance and molecular length than d-tubocurarine even when bent. To ... Atracurium, the resulting molecule, breaks down spontaneously in the body to inactive compounds and being especially useful in ... In the development of atracurium the main idea was to make use of Hofmann elimination of the muscle relaxant in vivo. When ...
A muscle relaxant such as atracurium would be administered after this, though this would not strictly be a part of coinduction ...
... atracurium, and cisatracurium. Succinylcholine is a widely used muscle relaxant drug which acts by activating, instead of ...
Unlike the pH- and temperature-dependent chemodegradation seen with atracurium and cisatracurium, the inactivation of ... of successful predecessor bistetrahydroisoquinolinium neuromuscular blocking drugs development projects such as atracurium ( ...
The molecular formula C65H82N2O18S2 (molar mass: 1243.49 g/mol) may refer to: Atracurium besilate Cisatracurium besilate This ...
The group held that the Syrian Interim Government was responsible for the accidental injection of atracurium besilate into 75 ...
... atracurium MeSH D03.438.531.085.077 - bicuculline MeSH D03.438.531.085.666 - papaverine MeSH D03.438.531.085.666.850 - ...
Mumps vaccine Varicella vaccine Atracurium Neostigmine Suxamethonium Vecuronium Pyridostigmineα Vecuroniumα Aciclovir ...
Additionally, the use of nondepolarizing neuromusclar blocking agents (NMBA), such as doxacurium or atracurium, have been ...
Atozine Oral atracurium besilate (INN) atreleuton (INN) atriciguat (INN) Atridox atrimustine (INN) atrinositol (INN) Atrohist ...
... atracurium besilate) Trelegy (fluticasone furoate, umeclidinium, and vilanterol inhalation powder) Treximet (sumatriptan and ...
M03AA04 Dimethyltubocurarine M03AB01 Suxamethonium M03AC01 Pancuronium M03AC02 Gallamine M03AC03 Vecuronium M03AC04 Atracurium ...
The molecular formula C21H27NO4 (molar mass: 357.44 g/mol) may refer to: Laudanosine, a toxic metabolite of atracurium and ...
Lei-Dab7 N-methyl-laudanosine N-Me-bicuculline Pancuronium Atracurium 1-ethyl-1H-benzo[d]imidazol-2(3H)-on 6,7-dichloro-3-( ...
Atracurium is available as a generic medication. Atracurium is a medication used in addition to other medications in to provide ... Atracurium besilate, also known as atracurium besylate, is a medication used in addition to other medications to provide ... Dewar first named this compound "33A74" before its eventual emergence in the clinic as atracurium. Atracurium was the ... and came to be known as atracurium. "Atracurium Besylate". The American Society of Health-System Pharmacists. Archived from the ...
"Comparative evaluation of atracurium dosed on ideal body weight vs. total body weight in morbidly obese patients". British ...
Atracurium is available as a generic medication. Atracurium is a medication used in addition to other medications in to provide ... Atracurium besilate, also known as atracurium besylate, is a medication used in addition to other medications to provide ... Dewar first named this compound "33A74" before its eventual emergence in the clinic as atracurium. Atracurium was the ... and came to be known as atracurium. "Atracurium Besylate". The American Society of Health-System Pharmacists. Archived from the ...
Learn about drug interactions between atropine iv and atracurium iv and use the RxList drug interaction checker to check drug ... All generic drug interactions for atracurium iv (lists will include brand and generic names): ...
... atracurium), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, ... encoded search term (atracurium (Tracrium)) and atracurium (Tracrium) What to Read Next on Medscape ... atracurium intravenous NO MONOGRAPH AVAILABLE AT THIS TIME USES: Consult your pharmacist. HOW TO USE: Consult your pharmacist. ... atracurium decreases levels of clozapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/ ...
A formulation for preparing Atracurium Besylate 10-mg/mL Injection, Preserved. Includes ingredients, method of preparation, ... Atracurium Besylate 10-mg/mL Injection, Preserved. Allen Loyd V Jr Jul/Aug 2014. 322. Buy. ... Abstract: A formulation for preparing Atracurium Besylate 10-mg/mL Injection, Preserved. Includes ingredients, method of ... Related Keywords: Loyd V. Allen, Jr., PhD, RPh, atracurium besylate, formulation, compounded sterile preparations, parenteral ...
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Atracurium is not considered suitable for operations of long duration. It can cause hypotension secondary to histamine release ...
Atracurium besylate, mixture of isomers 64228-81-5 from AK Scientific, in San Francisco, California ... Atracurium antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on ...
She was well-stabilized after general anesthesia and within the seconds of giving injection atracurium; she had difficulty in ... However, the incidence of anaphylaxis due to atracurium is very rare (,1/10,000) according to UK Summary of Product ... The patient was diagnosed with anaphylaxis with angioedema due to atracurium and was promptly managed in operation theater. She ... Sharma Jyoti, Verma Savita, Gupta M C. Atracurium-induced anaphylaxis and angioedema: a case report. International Journal of ...
Competitively inhibits the action of acetylcholine on postsynaptic nicotinic receptors, preventing acetylcholine-mediated muscle contraction ...
Find information on Atracurium (Tracrium) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... atracurium is a sample topic from the Daviss Drug Guide. To view other topics, please log in or purchase a subscription. ... "Atracurium." Daviss Drug Guide, 18th ed., F.A. Davis Company, 2023. Nursing Central Redesign, nursing.unboundmedicine.com/ ... nursingcentral/view/Davis-Drug-Guide/109671/all/atracurium. Vallerand AHA, Sanoski CAC, Quiring CC. Atracurium. Daviss Drug ...
Atracurium is a neuromuscular-blocking agent, used as an adjuvant in anesthesia. ...
Mathematically equivalent hydraulic analogue for teaching the pharmcokinetics and pharmacodynamics of atracurium. Journal of ... Mathematically equivalent hydraulic analogue for teaching the pharmcokinetics and pharmacodynamics of atracurium. / Nikkelen, A ... title = "Mathematically equivalent hydraulic analogue for teaching the pharmcokinetics and pharmacodynamics of atracurium", ... Mathematically equivalent hydraulic analogue for teaching the pharmcokinetics and pharmacodynamics of atracurium. ...
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Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
  • A formulation for preparing Atracurium Besylate 10-mg/mL Injection, Preserved. (ijpc.com)
  • COMPOSITION FOR ATRAPURE 2.5MG INJECTION Atracurium(2.5mg)FOOD INTERACTION FOR ATRAPURE INJECTION :It is better to take Atrapure 2.5mg injection empty stomach (1 hour before food or 2 hours after food). (dheerhealthcaredrugs.com)
  • Atracurium Besilate Injection is indicated as an adjunct to general anaesthesia during surgery to relax skeletal muscles, and to facilitate endotracheal intubation and mechanical ventilation. (cphi-online.com)
  • Atracurium Besylate Injection is made available in a gradation of packaging options, in order to facilitate safer deliveries. (skyhealthpharma.in)
  • Atracurium Besylate Injection is a skeletal muscle relaxant that is used in combination with anesthesia to assist endotracheal intubation and to calm skeletal muscles during surgery or mechanical breathing. (sriyalifescience.com)
  • Generic atracurium besylate injection is available. (sriyalifescience.com)
  • Only intravenous injections should be used to give Atracurium Besilate Injection. (sriyalifescience.com)
  • Atracurium Besilate Injection should not be administered intramuscularly due to the risk of tissue irritation and the lack of clinical evidence to support this practice. (sriyalifescience.com)
  • Atracurium Besilate Injection, like other neuromuscular blocking medications, requires monitoring of neuromuscular function in order to tailor dose needs. (sriyalifescience.com)
  • Our range of products include rocuronium bromide injection(10mg) mycuronium, ascorbic acid injection 250 mg/ml, vecuronium bromide for injection ( for export), rocuronium bromide injection (for export), cerebroprotein hydrolysate injection and atracurium besylate injection. (mayabiotech.co.in)
  • Atracurium besylate injection is available in generic form. (wellnesspharmaindia.com)
  • Elimination: atracurium, vecuronium, mivacurium. (myastheniagravis.cz)
  • Neuromuscular blocking drugs, such as vecuronium [7] and atracurium, [8] have also been added to the local anesthetic mixture and have been shown to improve the quality of peribulbar anesthesia. (saudija.org)
  • Evaluation of cumulative properties of three new nondepolarizing neuromuscular blocking drugs BW A444U, atracurium and vecuronium. (cornell.edu)
  • Some of the most common drugs include available drugs (such as propofol, etomidate, and fentanyl), local anesthetics (such as lidocaine and bupivacaine), and neuromuscular blocking agents (such as atracurium and vecuronium). (dentist-tulsa.com)
  • Dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation in humans[J]. Journal of Zhejiang University Science B, 2005, 6(9): 869-872. (zju.edu.cn)
  • Objective: To compare the dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation (OLT) in humans. (zju.edu.cn)
  • Methods: Twenty male patients undergoing liver transplantation were randomly assigned to two comparable groups of 10 patients each to receive a continuous infusion of rocuronium or atracurium under intravenous balanced anesthesia. (zju.edu.cn)
  • Conclusions: This study showed that the exclusion of the liver from the circulation results in the significantly reduced requirement of rocuronium while the requirement of atracurium was not changed, which suggests that the liver is of major importance in the clearance of rocuronium . (zju.edu.cn)
  • Examples of muscle relaxants used during surgical procedures include succinylcholine (Anectine, Sucostrin), atracurium (Tracrium), and pancuronium (Pavulon). (butalbitalacetaminophen.com)
  • In such cases, atracurium, cisatracurim , and succinylcholine should still have activity and may be considered. (pharmacytimes.com)
  • All patients will be induced with propofol 2 mg / kg , atracurium 0.5mg/kg and fentanyl 1μg/kg, then the patients will be intubated by appropriate size of endotracheal tube volume control ventilation (VCV) 5-7 ml/kg and respiratory rate will be adjusted to keep and PaCO2 levels between 30-35 mmHg using (G.E-Datex-Ohmeda, Avance CS2, USA) anesthesia machine. (centerwatch.com)
  • Sufentanil (0.2 μg/kg) propofol (2 mg/kg), atracurium (1 mg/kg) and midazolam (2 mg) were used for anesthesia induction. (medscape.com)
  • Anesthesia will be maintained with isoflurane 1 MAC with 50% oxygen in air, with the goal of keeping the BIS measurement between (40-60), and atracurium top-ups of 0.1mg/kg will be given every 30 minutes for neuromuscular blockade.Then the block will be conducted after general anesthesia by an expert anesthesiologist who is different from the anesthesiologist who provided anesthesia to the patient. (centerwatch.com)
  • Then sufentanil (0.1 μg/kg), atracurium (0.5 mg/kg) and sevoflurane (1-3%) were used to maintain anesthesia during surgery. (medscape.com)
  • Atracurium is in the neuromuscular-blocker family of medications and is of the non-depolarizing type. (wikipedia.org)
  • Pipecuronium bromide is an aminosteroidal competitive neuromuscular blocker (see Atracurium). (pocketdrugguide.com)
  • Atracurium besilate, also known as atracurium besylate, is a medication used in addition to other medications to provide skeletal muscle relaxation during surgery or mechanical ventilation. (wikipedia.org)
  • Because atracurium undergoes Hofmann elimination as a primary route of chemodegradation, one of the major metabolites from this process is laudanosine, a tertiary amino alkaloid reported to be a modest CNS stimulant with epileptogenic activity and cardiovascular effects such a hypotension and bradycardia. (wikipedia.org)
  • Elimination of atracurium in humans: Contribution of Hofmann elimination and ester hydrolysis versus organ-based elimination. (zju.edu.cn)
  • After the child was adequately anesthetized, atracurium 0.5mg/kg i.v was given to facilitate tracheal intubation. (ispub.com)
  • Both groups received 0.5mg.kg -1 atracurium to facilitate intubation and maintain muscle relaxation. (ipmj.net)
  • Bolus doses of atracurium were given to maintain only 2or 3 responses of TOF. (ispub.com)
  • The therapeutic efficacy of Atracurium can be increased when used in combination with Azlocillin. (drugbank.com)
  • Indeed, because laudanosine is cleared primarily via renal excretion, a cat study modelling anephric patients went so far as to corroborate that EEG changes, when observed, were evident only at plasma concentrations 8 to 10 times greater than those observed in humans during infusions of atracurium. (wikipedia.org)
  • amikacin increases effects of atracurium by pharmacodynamic synergism. (medscape.com)
  • amphotericin B deoxycholate increases effects of atracurium by pharmacodynamic synergism. (medscape.com)
  • huperzine A increases and atracurium decreases cholinergic effects/transmission. (medscape.com)
  • Nasotracheal intubation was done with a size 4 uncuffed endotracheal tube with flexible endoscopic guidance, and after confirmation of correct position of the endotracheal tube, muscle relaxation was achieved with atracurium (Artacil-100, 0.9 % /10 mg /10 ml, Neon Laboratories Ltd, India). (springeropen.com)
  • A continuous infusion of atracurium with constant rate can provide stable neuromuscular blockade during the three stages of OLT. (zju.edu.cn)
  • Assess respiratory status continuously throughout therapy with atracurium. (unboundmedicine.com)
  • Atracurium antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. (aksci.com)
  • 28 September 2014 - A World Health Organization (WHO) assessment of the cause of the death of 15 children in rural Idleb, northern Syria, has concluded that the most likely cause of the event was the incorrect use of a drug called Atracurium as a diluent for measles/rubella vaccine. (who.int)
  • Administration of anticholinesterase agents (neostigmine, pyridostigmine) may be used to antagonize the action of atracurium once the patient has demonstrated some spontaneous recovery from neuromuscular block. (unboundmedicine.com)
  • May enhance the action of neuromuscular blocking agents (e.g. atracurium). (medicscientist.com)
  • At simultaneous application with atrakury besylate the effects of atracurium besylate are prolonged. (lekarstwo.ru)