Atracurium: A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.Neuromuscular Nondepolarizing Agents: Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.Neuromuscular Blocking Agents: Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.Vecuronium Bromide: Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.Pancuronium: A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release.Isoquinolines: A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.Succinylcholine: A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.Androstanols: Androstanes and androstane derivatives which are substituted in any position with one or more hydroxyl groups.Neuromuscular Junction: The synapse between a neuron and a muscle.Neuromuscular Depolarizing Agents: Drugs that interrupt transmission at the skeletal neuromuscular junction by causing sustained depolarization of the motor end plate. These agents are primarily used as adjuvants in surgical anesthesia to cause skeletal muscle relaxation.Anesthesia, General: Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.Neuromuscular Blockade: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.Enflurane: An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.Anesthesia, Inhalation: Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.Anesthesia, IntratrachealOpium: The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.Ulnar Nerve: A major nerve of the upper extremity. In humans, the fibers of the ulnar nerve originate in the lower cervical and upper thoracic spinal cord (usually C7 to T1), travel via the medial cord of the brachial plexus, and supply sensory and motor innervation to parts of the hand and forearm.Halothane: A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)Anesthesia Recovery Period: The period of emergence from general anesthesia, where different elements of consciousness return at different rates.Tritolyl Phosphates: A mixture of isomeric tritolyl phosphates. Used in the sterilization of certain surgical instruments and in many industrial processes.Glycopyrrolate: A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.Thumb: The first digit on the radial side of the hand which in humans lies opposite the other four.Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.Nerve Block: Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Histamine Release: The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.Thiopental: A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.Ranitidine: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.Dimethindene: A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.Radiation ProtectionHydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.EstersAnesthesiology: A specialty concerned with the study of anesthetics and anesthesia.Gestalt Therapy: A form of psychotherapy with emphasis on the interplay of organism and environment. Basic to this therapy is the development of awareness and maturity, as well as self-confidence.Laryngeal Masks: A type of oropharyngeal airway that provides an alternative to endotracheal intubation and standard mask anesthesia in certain patients. It is introduced into the hypopharynx to form a seal around the larynx thus permitting spontaneous or positive pressure ventilation without penetration of the larynx or esophagus. It is used in place of a facemask in routine anesthesia. The advantages over standard mask anesthesia are better airway control, minimal anesthetic gas leakage, a secure airway during patient transport to the recovery area, and minimal postoperative problems.Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.Laryngismus: A disorder in which the adductor muscles of the VOCAL CORDS exhibit increased activity leading to laryngeal spasm. Laryngismus causes closure of the VOCAL FOLDS and airflow obstruction during inspiration.Intubation, Intratracheal: A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.Anesthetics, Intravenous: Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)Ondansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.Congenital Abnormalities: Malformations of organs or body parts during development in utero.Antiemetics: Drugs used to prevent NAUSEA or VOMITING.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.Western Australia: A state in western Australia. Its capital is Perth. It was first visited by the Dutch in 1616 but the English took possession in 1791 and permanent colonization began in 1829. It was a penal settlement 1850-1888, became part of the colonial government in 1886, and was granted self government in 1890. (From Webster's New Geographical Dictionary, 1988, p1329)Cephaelis: A plant genus of the family RUBIACEAE, order Rubiales, subclass Asteridae. Cephaelis ipecacuanha is the source of IPECAC.

Influence of atracurium on the diaphragm mean action potential conduction velocity in canines. (1/168)

BACKGROUND: It has been shown that progressive neuromuscular blockade (NMB) affects the electromyogram power spectrum and compound muscle action potential duration in skeletal muscle. These measures are linked to the mean muscle action potential conduction velocity (APCV), but no studies have confirmed a relation between the mean APCV and NMB. The aim of this study was to determine whether diaphragm mean APCV is affected by NMB. METHODS: The effects of NMB on diaphragm mean APCV were evaluated in five mongrel dogs. Progressive NMB was induced by slow intravenous infusion of atracurium. During spontaneous breathing, the diaphragm mean APCV was determined by electromyogram signals, in the time and frequency domains. The magnitude of NMB was quantified by the amplitude of the compound muscle action potential and by changes in muscle shortening during supramaximal stimulation of the phrenic nerve. RESULTS: Progressive NMB was associated with a decrease in diaphragm mean APCV. At approximately 70% reduction in the compound muscle action potential amplitude, diaphragm mean APCV had decreased more than 20%. Recovery after NMB was characterized by a restoration of the mean APCV to control values. CONCLUSION: This study shows that progressive NMB paralyzes motor units within the diaphragm in an orderly manner, and the blockade first affects muscle fibers with high APCV before it affects fibers with lower APCV.  (+info)

The infusion rate of mivacurium or atracurium for cesarean section compared with gynecological procedures. (2/168)

Mivacurium is mainly metabolized by plasma cholinesterase, whereas atracurium is removed by Hofman elimination. The purpose of this study was to compare the infusion rate of atracurium and mivacurium in maintaining surgical relaxation, and to compare their recovery indices between parturients and non-pregnant women. Muscle relaxation was maintained by the continuous infusion of relaxants to retain the first response of train-of-four (TOF) at 5% of control. When mivacurium was used, Bolus-T5 (duration from the end of mivacurium bolus injection to 5% single twitch recovery) was measured. After discontinuing the infusion, the recovery index was measured. The infusion rate of mivacurium, not atracurium, was significantly lower in parturients and Bolus-T5 of parturients was significantly longer than that of non-pregnant women. There was no significant difference in the recovery indices of both relaxants. The authors concluded that the infusion rate of mivacurium in maintaining muscle relaxation in parturients should be reduced compared to the rate in non-pregnant women and measuring Bolus-T5 may be helpful in determining the infusion rate to maintain muscle relaxation.  (+info)

Comparison of a new piezoelectric train-of-four neuromuscular monitor, the ParaGraph, and the Relaxometer mechanomyograph. (3/168)

The ParaGraph is a new device for monitoring neuromuscular function using a piezoelectric motion sensor. In 20 patients, monitoring of neuromuscular block produced by cisatracurium 0.1 mg kg-1 was compared using the ParaGraph and a Relaxometer 2 mechanomyograph. The ParaGraph was quick to set up, and easy to operate and interpret. There were no significant differences in the time to 100% depression of T1/T0, time to 25% recovery of T1/T0 or time to recovery of T1/T0 from 25% to 75%, measured by the two monitors. When the difference between the two monitors was plotted against the average of the two measurements, the limits of agreement for T1/T0 (-42.95, +53.98%) and the train-of-four ratio, T4/T1 (-0.28, +0.21) were too wide to allow the values given by the two monitors for individual patients to be used interchangeably.  (+info)

Cisatracurium neuromuscular block at the adductor pollicis and the laryngeal adductor muscles in humans. (4/168)

We have compared the dose-response relationship (n = 30) and time course of neuromuscular block (n = 20) of cisatracurium at the laryngeal adductor and the adductor pollicis muscles. ED95 values for cisatracurium were 66.8 (95% confidence interval 61.3-72.3) micrograms kg-1 at the larynx and 45.2 (42.1-48.3) micrograms kg-1 at the adductor pollicis muscle (P < 0.0001). After administration of cisatracurium 0.1 mg kg-1, onset time was 2.7 (2.2-3.2) min at the larynx and 3.9 (3.0-4.8) min at the adductor pollicis (P < 0.0001). Time to 95% recovery of the first twitch of the TOF was 26.9 (20.1-33.7) min and 45.6 (39.7-51.5) min, respectively (P < 0.0001). We found that the laryngeal adductors were more resistant to the action of cisatracurium than the adductor pollicis muscle, but onset and recovery were faster at the larynx.  (+info)

A comparison of continuous infusion of vecuronium and atracurium in midline and paramedian laparotomies. (5/168)

This was a study to compare continuous intravenous infusion of atracurium with continuous intravenous infusion of vecuronium for intraoperative muscle relaxation in 62 ASA I / II patients. Scheduled for laparotomies and pelvic surgeries under general anaesthesia. They were randomly allocated in two groups to receive either vecuronium infusion of 50 microg/kg/hour following a bolus dose of 0.1 microg/kg, or atracurium infusion of 400 microg/kg/hour following a bolus dose of 0.5 microg/kg. The mean infusion dose of atracurium was 478 +/- 44.11 microg/kg/hour and that of vecuronium was 63.2 +/- 74 microg/kg/hour for adequate muscle relaxation. The depth of neuromuscular blockade was monitored by using peripheral nerve stimulator so that only one twitch of train of four was present, resistance to ventilation, surgical relaxation and haemodynamic changes. Vecuronium infusions produced more haemodynamic stability than atracurium infusions. Vecuronium produced lesser change in systolic blood pressure (mean change of 3. 46 +/- 3.33%) from baseline values as compared to atracurium (mean change of 5.81 +/- 3.73%) from baseline values ( p < 0.01) which was statistically significant. The difference in mean pulse rate change from baseline value in the atracurium group (4.78 +/- 2.745%) was less than that in the vecuronium group (5.99 +/- 2.67%), which was not statistically significant. Spontaneous recovery was faster with vecuronium (540.94 +/- 76.46 seconds) as compared to atracurium (596. 33 +/- 72.48 seconds). 84.4% of patients who received vecuronium fell within good to very good category of muscle relaxation as compared to 63.3% in atracurium group. There were no cost benefits when either agents were used in infusion form.  (+info)

The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium. (6/168)

BACKGROUND: Residual neuromuscular block caused by vecuronium alters pharyngeal function and impairs airway protection. The primary objectives of this investigation were to radiographically evaluate the swallowing act and to record the incidence of and the mechanism behind pharyngeal dysfunction during partial neuromuscular block. The secondary objective was to evaluate the effect of atracurium on pharyngeal function. METHODS: Twenty healthy volunteers were studied while awake during liquid-contrast bolus swallowing. The incidence of pharyngeal dysfunction was studied by fluoroscopy. The initiation of the swallowing process, the pharyngeal coordination, and the bolus transit time were evaluated. Simultaneous manometry was used to document pressure changes at the tongue base, the pharyngeal constrictor muscles, and the upper esophageal sphincter. After control recordings, an intravenous infusion of atracurium was administered to obtain train-of-four ratios (T4/T1) of 0.60, 0.70, and 0.80, followed by recovery to a train-of-four ratio of more than 0.90. RESULTS: The incidence of pharyngeal dysfunction was 6% during the control recordings and increased (P < 0.05) to 28%, 17%, and 20% at train-of-four ratios 0.60, 0.70, and 0.80, respectively. After recovery to a train-of-four ratio of more than 0.90, the incidence was 13%. Pharyngeal dysfunction occurred in 74 of 444 swallows, the majority (80%) resulting in laryngeal penetration. The initiation of the swallowing reflex was impaired during partial paralysis (P = 0.0081). The pharyngeal coordination was impaired at train-of-four ratios of 0.60 and 0.70 (P < 0.01). A marked reduction in the upper esophageal sphincter resting tone was found, as well as a reduced contraction force in the pharyngeal constrictor muscles. The bolus transit time did not change significantly. CONCLUSION: Partial neuromuscular paralysis caused by atracurium is associated with a four- to fivefold increase in the incidence of misdirected swallowing. The mechanism behind the pharyngeal dysfunction is a delayed initiation of the swallowing reflex, impaired pharyngeal muscle function, and impaired coordination. The majority of misdirected swallows resulted in penetration of bolus to the larynx.  (+info)

Dose requirements of infusions of cisatracurium or rocuronium during hypothermic cardiopulmonary bypass. (7/168)

We investigated the influence of mild hypothermic cardiopulmonary bypass (CPB) on the dose requirements of cisatracurium or rocuronium used as a continuous infusion. We studied eight patients given cisatracurium and nine given rocuronium. They were ASA class III and IV and scheduled for elective coronary artery bypass grafting. Neuromuscular transmission was monitored electromyographically. After recovery of T1/T0 to 10%, a cisatracurium infusion or a rocuronium infusion was started at a rate of 1.5 or 10 micrograms kg-1 min-1, respectively, and adjusted to maintain T1/T0 at 15%. Infusion rate and duration were recorded before, during and after CPB in each patient and the mean infusion rates were calculated. One-way ANOVA showed a statistically significant difference between the cisatracurium infusion rates before, during and after CPB: A T1/T0 of 15% could be achieved with a mean infusion rate of 1.1, 0.75 and 0.98 micrograms kg-1 min-1 before, during and after CPB, respectively. There was no significant difference between the rocuronium infusion rates before, during and after CPB. The mean rocuronium infusion rate required to maintain T1/T0 at 15% throughout the procedure was 4.1 micrograms kg-1 min-1. Cisatracurium infusion rates should be halved during CPB. Even after CPB, requirements are reduced. The same tendency occurs with rocuronium, but the changes in infusion rate were not statistically significant.  (+info)

Preanesthetic train-of-four fade predicts the atracurium requirement of myasthenia gravis patients. (8/168)

BACKGROUND: The most sensitive diagnostic criterion of myasthenia gravis is a decrement in the muscular response to repetitive stimulation. The authors hypothesized that myasthenia gravis patients who show a train-of-four ratio (T4/T1) < 0.9 in the preanesthetic period will have increased sensitivity to nondepolarizing neuromuscular blocking agents compared with myasthenia gravis patients with preanesthetic T4/T1 > or = 0.9. METHODS: After institutional review board approval was obtained, 20 electrophysiologically documented myasthenia gravis patients were studied. Current pyridostigmine therapy was continued until the morning of surgery. Before induction of anesthesia, neuromuscular transmission was recorded from the hypothenar muscles using electromyography with train-of-four stimulation of the ulnar nerve. According to the T4/T1 ratio, patients were assigned to the "normal" group (T4/T1 > or = 0.9) or the "decrement" group (T4/T1 < 0.9). After induction of intravenous anesthesia, the effective dose to achieve a 95% neuromuscular blockade (ED95) for atracurium was assessed with a cumulative bolus technique. Postoperatively, pyridostigmine was titrated to obtain a T4/T1 > 0.75 and to treat residual myasthenic symptoms. RESULTS: In 14 patients, preanesthetic T4/T1 was > or = 0.9 (normal), whereas 6 patients presented with T4/T1 < 0.9 (decrement). Decrement patients had a lower ED95 of 0.07 +/- 0.03 mg/kg atracurium (mean +/- SD) compared with normal patients with an ED95 of 0.24 +/- 0.11 mg/kg atracurium (P = 0.002). All patients were extubated within 30 min after surgery. Postoperative pyridostigmine infusion did not differ significantly between groups. CONCLUSIONS: The requirement for atracurium is significantly reduced in myasthenia gravis patients with a T4/T1 ratio < 0.9 before anesthesia. This study indicates that routine neuromuscular monitoring in myasthenia gravis patients should be extended into the preinduction period to identify patients who require less atracurium.  (+info)

Dennis M. Fisher, P. Claver Canfell, Mark R. Fahey, Judith I. Rosen, Stephen M. Rupp, Lewls B. Sheiner, Ronald D. Miller; Elimination of Atracurium in Humans: Contribution of Hofmann Elimination and Ester Hydrolysis versus Organ-based Elimination. Anesthesiology 1986;65(1):6-12. Download citation file:. ...
A prospective, randomized, double-blind study was performed in 40 patients (ASA class I-III) treated with atracurium to ascertain whether histamine release caused hemodynamic or cutaneous changes. The treated group of 20 patients was premedicated with the H1 antagonist dimetindene (0.2 mg/kg) and the H2 antagonist ranitidine (1.25 mg/kg); the control group of 20 patients received saline. Six minutes after the induction of anesthesia with thiopental/fentanyl, patients received atracurium 0.5 mg/kg over 5 s. Plasma histamine levels were measured fluorometrically 5 min after administration of thiopental/fentanyl and 2 and 5 min after atracurium. Arterial blood pressure and heart rate were recorded every 2 min. Histamine levels (0.24 ng/mL) did not change significantly after thiopental/fentanyl. In the control group, 2 min after injection of atracurium, plasma histamine levels were 0.76 +/- 0.76 ng/mL, and in the antihistamine-treated group, 0.39 +/- 0.24 ng/mL (P , 0.05 control versus treated), ...
The Hofmann rearrangement is the organic reaction of a primary amide to a primary amine with one fewer carbon atom. The reaction is named after its discoverer - August Wilhelm von Hofmann. This reaction is also sometimes called the Hofmann degradation, and should not be confused with the Hofmann elimination. The reaction of bromine with sodium hydroxide forms sodium hypobromite in situ, which transforms the primary amide into an intermediate isocyanate. The formation of an intermediate nitrene is not possible because it implies also the formation of an hydroxamic acid as a byproduct, which has never been observed. The intermediate isocyanate is hydrolyzed to a primary amine, giving off carbon dioxide. Base abstracts an acidic N-H proton, yielding an anion. The anion reacts with bromine in an α-substitution reaction to give an N-bromoamide. Base abstraction of the remaining amide proton gives a bromoamide anion. The bromoamide anion rearranges as the R group attached to the carbonyl carbon ...
Administration of atracurium in dogs undergoing laparoscopic ovariectomy with a standardised ventilation pattern did not result in clinically important differences in selected
Hofmann S, Everaars J, Schweiger O, Frenzel M, Bannehr L, Cord AF (2017) Modelling patterns of pollinator species richness and diversity using satellite image texture. PLOS ONE [https://doi.org/10.1371/journal.pone.0185591]. Zimmermann A, Knecht H, Haesler R, Zissel G, Gaede K, Hofmann S, Nebel A, Mueller-Quernheim J, Schreiber S, Fischer A (in press) Atopobium and Fusobacterium as novel candidates for sarcoidosis associated microbiota. European Respiratory Journal 50: 1600746 [doi: 10.1183/13993003.00746-2016]. Hofmann S, Stöck M, Zheng Y, Ficetola GF, Li J, Scheidt U, Schmidt J (2017) Molecular Phylogenies indicate a Paleo-Tibetan Origin of Himalayan Lazy Toads (Scutiger). Scientific Reports 7:3308; press release in Englisch, Deutsch and Koreanisch [https://doi:10.1038/s41598-017-03395-4].. Hofmann S, Fritzsche P, Miehe G (2016) First record of Elaphe dione from high altitude in Western Sichuan reveals high intraspecific differentiation. Salamandra 52:273-277.. Mohapatra P, Schulz KD, ...
A 7-month-old, 7-kg infant received 6 mg cisatracurium intravenously after induction of anesthesia with nitrous oxide and halothane. There was no change in heart rate, noninvasive blood pressure obtained with the cuff on the upper arm, or skin color, but when the surgery was concluded, neuromuscular block persisted to the extent that no posttetanic count could be elicited. The infant received midazolam and mechanical ventilation in the recovery room. One hundred minutes after the dose of 0.86 mg/kg cisatracurium, a very slight response of the adductor pollicis to stimulation of the ulnar nerve with 2 Hz, a train-of-four (TOF) every 60 s was documented by the Datex neuromuscular transmission monitor electromyogram in the uncalibrated mode. One hundred and ten minutes after the bolus of cisatracurium, four responses to the TOF were recorded. At this time, the patients diaphragm, fingers, and toes were moving spontaneously. Propofol was administered by infusion to produce immobility. During the ...
Both overfeeding and underfeeding of intensive care unit (ICU) patients are associated with worse outcomes. A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomena. Several factors that influence EE have been studied previously. However, the effect of neuromuscular blocking agents on EE, which conceptually would lower EE, has not been extensively investigated. We studied a cohort of adult critically ill patients requiring invasive mechanical ventilation and treatment with continuous infusion of cisatracurium for at least 12 h. The study aimed to quantify the effect of cisatracurium infusion on EE (primary endpoint). EE was estimated based on ventilator-derived VCO2 (EE in kcal/day = VCO2 × 8.19). A subgroup analysis of septic and non-septic patients was performed. Furthermore, the effects of body temperature and sepsis on EE were evaluated. A secondary endpoint was hypercaloric feeding (| 110% of EE) after cisatracurium infusion. In total, 122 patients
I Have Something to Tell You by Regan Hofmann - For ten years, Regan Hofmann lived a double life. To the world, she was a woman from Princeton who went to prep...
Professional guide for Cisatracurium Besylate. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Cisatracurium Besylate reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).
Intraoperative Course. I. Monitoring requirements. 1. What electrocardiogram leads will you monitor? Explain.. 2. Could the Dinamap, pulse oximetry, and end-tidal CO2 take the place of an arterial catheter?. 3. If an arterial catheter is used, are pulse oximetry and end-tidal oximetry necessary?. II. Choices and management of anesthesia. 1. Would you use etomidate for induction? Explain.. 2. What is your choice for induction? Explain your rationale.. 3. What steps will you take to prevent the hypertensive response to laryngoscopy and intubation?. 4. Why is this important?. 5. Would halothane be a good choice for maintenance? Explain.. 6. Is narcotic only anesthesia preferred? Explain.. 7. Compare the circulatory effects of these drugs.. 8. Relate these choices to postoperative planning.. III. Management of muscle relaxation. 1. Would an atracurium infusion be your choice?. 2. What would determine dose requirements?. 3. How will you monitor effect?. 4. When will you reverse paralysis, and how ...
Hofmann, W., Baumert, A., & Schmitt, M. (2005). Heute haben wir Hitler im Kino gesehen: Evaluation der Wirkung des Films der Untergang auf Schüler und Schülerinnen der neunten und zehnten Klasse [Today we saw Hitler at the cinema: Evaluation of the effects of the film "Der Untergang" (downfall) on ninth and tenth grade students]. Zeitschrift für Medienpsychologie, 17, 132-146. doi:10.1026/1617-6383.17.4.132 ...
Hofmann, W., Baumert, A., & Schmitt, M. (2005). Heute haben wir Hitler im Kino gesehen: Evaluation der Wirkung des Films der Untergang auf Schüler und Schülerinnen der neunten und zehnten Klasse [Today we saw Hitler at the cinema: Evaluation of the effects of the film "Der Untergang" (downfall) on ninth and tenth grade students]. Zeitschrift für Medienpsychologie, 17, 132-146. doi:10.1026/1617-6383.17.4.132 ...
Dr. Hofmann first synthesized the compound in 1938, while researching ergot derivatives as a chemist for Sandoz Pharmaceuticals in Basel. The substance was tested on lab animals with no interesting results, so like hundreds of ...
Unveiled at Autopromotec 2015 - Bologna - the renewed series geodyna wheel balancers Hofmann, with touchscreen monitor and automatic non-contact data entry.. ...
This study investigated optimal dose of combination of Rocuronium and Cisatracurium through monitoring neuromuscular relaxation during surgery.
Thesis, English, Comparison of Kinemyography with Electromyography Neuromuscular Monitoring in Pediatric Patients Receiving Cisatracurium or Rocuronium during General Anesthesia for Abdel Aziz Mohammed Abdel Rahmn
The herbs boosted her milk production to a couple of ounces per day. Hofmann froze her milk in the hope that shed be able to share it with a baby some day.. After four months, Hofmann added domperidome to her daily routine of pumping and herbs. This medication has long been used to treat stomach disorders but had the side effect of causing lactation. After adding domperidome, Hofmanns milk production ballooned to upwards of 10 ounces per day.. "The only thing that is missing when you induce lactation is that you dont get the colostrum in the first couple of days. Other than that, my breast milk is the same as anyone else that has given birth," Hofmann said. ...
April 19, 1943, Hoffmann performed a self-experiment to determine the true effects of LSD, intentionally ingesting 0.25 milligrams (250 micrograms) of the substance, an amount he predicted to be a threshold dose (an actual threshold dose is 20 micrograms).[7] Less than an hour later, Hofmann experienced sudden and intense changes in perception. He asked his laboratory assistant to escort him home and, as use of motor vehicles was prohibited because of wartime restrictions, they had to make the journey on a bicycle. On the way, Hoffmans condition rapidly deteriorated as he struggled with feelings of anxiety, alternating in his beliefs that the next-door neighbor was a malevolent witch, that he was going insane, and that the LSD had poisoned him. When the house doctor arrived, however, he could detect no physical abnormalities, save for a pair of incredibly dilated pupils. Hofmann was reassured, and soon his terror began to give way to a sense of good fortune and enjoyment, as he later wrote... ...
Dr. Jonathan Reiner, Cheneys cardiologist, asked Dr. Lewis Hofmann, Cheneys White House physician, to arrange for the potassium test to be repeated tonight (see (Late Afternoon) September 11, 2001). Consequently, while he is accompanying Cheney as the vice president is being flown by helicopter to Camp David (see Shortly After 10:00 p.m. September 11, 2001), Hofmann passes Cheney a note, informing him that he needs to provide another sample of blood. Cheney, though, refuses to do so. "Not tonight, Lew, you can have it in the morning," he says. Whether he is aware of the results of the test on his blood sample from this morning and the possible danger he is in are unstated ...
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Thanks & regards, Avinash Joshi On 1/31/08, Frank.Hofmann at sun.com ,Frank.Hofmann at sun.com, wrote: , On Thu, 31 Jan 2008, Antonello Cruz wrote: , , , James Carlson wrote: , ,, Seeing those submitters go to the relevant community or project , ,, mailing list with a proposed patch (or better yet a pointer to a , ,, webrev) would be greatly preferred, and if we can gently guide them , ,, there when they mistakenly post changes here, thatd be good. , , Quick question: Do the contributors have access to the tools to generate , , webrevs? , , If youve got a full opensolaris source tree, youll find it in: , , usr/src/tools/scripts/webrev.sh , , FrankH. , _______________________________________________ , request-sponsor mailing list , request-sponsor at opensolaris.org , -- Sent from Gmail for mobile , mobile.google.com Thanks & Regards, Avinash Joshi AM106IT015 Department of Information Technology Amrita School of Engineering Amrita Vishwa Vidyapeetham Amritapuri Campus Clappana P.O., Kollam 690 ...
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This book offers a comprehensive survey of basic elements of nuclear dynamics at low energies and discusses similarities to mesoscopic systems. It addresses systems with finite excitations of their internal degrees of freedom, so that their collective motion exhibits features typical for transport processes in small and isolated systems.
Cleanliness is one the biggest draws of living with cats. So, if you start to detect a bad odor from your cat, you need to take notice. In most cases, foul feline smells are a sign that something is seriously wrong. ...
OBJECTIVES. The objectives of this study were the evaluation of the intraoperatory analgesia of remifentanil in dogs, comparing with fentanyl and a placebo solution, and the study of the hemodynamic and respiratory response and the patient recovery after two hours of anesthesia.. MATERIALS. Seven beagles dogs ASA I were anesthetized three times. All dogs were anaesthetized with medetomidine (10 mcg/kg IV), propofol (3 mg/kg IV, sevoflurane and atracurium (150 mcg/kg IV every 30 minutes. Three different analgesic protocols were evaluated: RMF: (remifentanil: 0,5 mcg/kg IV + 0,25 mcg/kg/min. FEN (2 mcg/kg IV + 0,1 mcg/kg/min IV). PCB (glucosade fluid infusion). In all cases the following postanesthetic analgesic protocol was used: morphine (0,2 mg/kg IM) and meloxicam (0,2 mg/kg IV) 20 minutes before the end of the procedure. Several cardiovascular and respiratory variables were studied every 5 minutes. Pain response was observed evaluated with a pinch with a forceps in the back paws. Recovery ...
Literature References: Prepn: Hofmann, Ber. 10, 213 (1877); Maximoff, US 2053095 (1935 to Azodal Co.). Prepn of salt: DE 562392 (1933 to Chem.-Pharm. Fabrik Hubold & Bartsch). See also Colour Index vol. 4 (3rd ed., 1971) p 4019; H. J. Conns Biological Stains, R. D. Lillie, Ed. (Williams & Wilkins, Baltimore, 9th ed., 1977) p 87. ...
Rintoul, S. R. , Sparrow, M. , Meredith, M. P. , Wadley, V. , Speer, K. , Hofmann, E. , Summerhayes, C. , Urban, E. , Bellerby, R. , Ackley, S. , Alverson, K. , Ansorge, I. , Aoki, S. , Azzolini, R. , Beal, L. , Belbeoch, M. , Bergamasco, A. , Biuw, M. , Boehme, L. , Budillon, G. , Campos, L. , Carlson, D. , Cavanagh, R. , Charpentier, E. , Chul Shin, H. , Coffin, M. , Constable, A. , Costa, D. , Cronin, M. , De Baar, H. , De Broyer, C. , De Bruin, T. , De Santis, L. , Butler, E. , Dexter, P. , Drinkwater, M. , England, M. , Fahrbach, E. , Fanta, E. , Fedak, M. , Finney, K. , Fischer, A. , Frew, R. , Garzoli, S. , Gernandt, H. , Gladyshev, S. , Gomis, D. , Gordon, A. , Gunn, J. , Gutt, J. , Haas, C. , Hall, J. , Heywood, K. , Hill, K. , Hindell, M. , Hood, M. , Hoppema, M. , Hosie, G. , Howard, W. , Joiris, C. , Kaleschke, L. , Kang, S. H. , Kennicutt, M. , Klepikov, A. , Lembke-Jene, L. , Lovenduski, N. , Lytle, V. , Mathieu, P. P. , Moltmann, T. , Morrow, R. , Muelbert, M. , Murphy, E. , ...
Direct analysis of underivatized amino acids in plant extracts by LC-MS-MS. In: M.A. Alterman, P. Hunziker (Eds.) Amino Acid Analysis, Humana Press, New York, 2012, 317 - 328, ISBN 978-1-61779-444-5.. N.D. Jablonowski, A. Linden, S. Köppchen, B. Thiele, D. Hofmann, W. Mittelstaedt, T. Pütz, P. Burauel ...
Sotillo E., Barrett D., Black K., Bagashev A., Oldridge D., Wu G., Sussman R., Lanauze C., Gazzara M, Martinez N., Ruella M., Harrington C., Chung E., Perazzelli J., Hofmann T., Maude S., Raman P., Barrera A., Gill S., Lacey S., Melenhorst J., Allman D., Jacoby E., Fry T., Mackall C., Barash Y., Lynch K., Maris J, Grupp S.,Thomas-Tikhonenko A.: Convergence of acquired mutations and alternative splicing of CD19 enables resistance to CART-19 immunotherapy. Cancer Discovery 5(12): 1282-95, December 2015 Notes: Contribution: Dr. Barash lab detected novel splicing variations in patients RNASeq, predicted splice regulator using the labs algorithms. This led to the main result of identifying SRFS3 expression as promoting CART19 escape and relapse ...
Kislinger T, Tanji N, Wendt T, Qu W, Lu Y, Ferran LJ, Taguchi A, Olson K, Bucciarelli L, Goova M, Hofmann MA, Cataldegirmen G, DAgati V, Pischetsrieder M, Stern DM, Schmidt AM ...
With leading local representatives and TUM President Thomas F. Hofmann in attendance, scientists from the Technical University of Munich (TUM) presented their trailblazing work on robot assistants at the User and Research Center for Geriatronics in Garmisch-Partenkirchen. In times of demographic change and an ageing population, their work is bringing technical support systems for dignified and autonomous living in old age within reach. The aim is to establish a "geriatronics campus" as an international reference center. It will bring together under one roof modern research and teaching with new nursing care and residential concepts for the third and fourth stages of ageing. ...
The Eagles seem incapable of putting anybody away early. Maybe that will change, maybe some day, but as the evidence mounts, it does not seem likely. They are a good offense, but mistake-prone. They are a stingy defense, but make few big plays. The result is agony. Get used to it -- and double up on the prescription for nitroglycerin pills during the bye week. - Rich Hofmann, Philadelphia Daily News
The Eagles seem incapable of putting anybody away early. Maybe that will change, maybe some day, but as the evidence mounts, it does not seem likely. They are a good offense, but mistake-prone. They are a stingy defense, but make few big plays. The result is agony. Get used to it -- and double up on the prescription for nitroglycerin pills during the bye week. - Rich Hofmann, Philadelphia Daily News
These transporters are proteins of from 420 to 573 amino acids which are highly hydrophobic and which probably contain about 10 transmembrane regions. As signature patterns, we selected two conserved regions. The first pattern is located in the N-terminal section and seems to include a hydrophilic region between two transmembrane regions. The second pattern is located in the C-terminal section. Expert(s) to contact by email: Hofmann K ...
Purpose: To compare the laryngeal mask airway (LMA) insertion conditions produced by propofol and a thiopental - low dose atracurium combination. Methods: In a randomized controlled double blind study, 120 premedicated patients were allocated into four groups. After pre-oxygenation, anesthesia was induced as follows: 1 μg · kg-1 fentanyl, 2.5 mg · kg-1 propofol (group I); 1 μg · kg-1 fentanyl, 5 mg · kg-1 thiopental (group II); 1 μg · kg-1 fentanyl, 5 mg · kg-1 thiopental, 0,05 mg · kg-1 or 0.1 mg · kg-1 atracurium (groups III and IV respectively). The LMA was inserted by a blinded anesthesiologist who also assessed the following insertion conditions on a three point scale; jaw relaxation, biting, gagging, coughing, presence of laryngospasm, adequacy of airway patency, number of attempts at insertion and overall insertion conditions. Results: There was no difference in insertion conditions between groups I, III and IV. Group II produced the worst overall conditions (P , 0.05). There ...
en] We studied the effects of intravenous ephedrine on the onset time and the intubating conditions 2 min after a bolus dose of cisatracurium (0.15 mg kg-1). Thirty patients anaesthetized with sufentanil and propofol were randomly divided in 2 groups to receive either ephedrine (70 micrograms.kg-1) or saline, 5 s before propofol. Cisatracurium was administered after loss of consciousness. Neuromuscular block was assessed at the adductor pollicis using accelography. Tracheal intubation was performed 2 min after cisatracurium injection and rated as excellent, good, poor or bad. At intubation, neuromuscular block (% height of control T1) was greater in patients receiving ephedrine (36.1 +/- 25.8% vs 57.9 +/- 25.1%) (mean +/- SD). The frequency of excellent intubating conditions was higher after ephedrine (86.6%) than after saline (40.0%). The onset time of cisatracurium was shorter after ephedrine (167 +/- 64.8 s vs 234.9 +/- 63.1 s). Thus, a low dose of ephedrine given before induction of ...
Dr. R. Jeffrey Hofmann, a board certified ophthalmologist, specializes in ophthalmic plastic and reconstructive surgery including laser and cosmetic surgery. He has been a fellow of the American Society of Ophthalmic Plastic and Reconstructive Surgery since 1987 (see www.ASOPRS.org). Dr. Hofmann is a full-time staff member at Rhode Island Hospital, Miriam Hospital, and Hasbro Childrens Hospital, as well as Director of the Oculoplastic Surgery Clinic at the Veterans Administration Hospital in Providence. He is a Clinical Assistant Professor of Surgery at Browns Warren Alpert School of Medicine at Brown University and teaches medical students and residents.. Dr. Hofmann graduated summa cum laude from Tulane University, and went on to receive his medical degree with distinction - Alpha Omega Alpha - from Tulane University School of Medicine. He interned at Barnes Hospital in St. Louis, MO, and completed his residency in Ophthalmology at Washington University in St. Louis. He then pursued ...
THE man who synthesised LSD and became the first person to ever have an acid trip has died at the age of 102.. Swiss scientist Albert Hofmann died of a heart attack at his home in Basel yesterday, a friend and colleague said.. Dr Hofmann was working as a chemist in Basel when he synthesised lysergic acid diethylamide.. On April 19, 1943, he took the substance before cycling home. That day has become known among aficionados as "Bicycle Day" as it was while he was riding home that he experienced the most intense symptoms brought on by the drug. Dr Hofmann was also the first person to synthesise psilocybin, the active constituent of "magic mushrooms". He also discovered the hallucinogenic principles of Ololiuqui (Morning Glory), lysergic acid amide and lysergic acid hydroxyethylamide. He disapproved of the appropriation of LSD by the youth movements of the 1960s, but regretted that its potential uses had not been explored ...
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Intraoperative Course. I. Selection of monitoring. 1. How will you assess the adequacy of renal perfusion during surgery? Explain.. 2. Is a pulmonary artery catheter necessary? Explain.. 3. After placement of a pulmonary artery catheter, pulmonary artery pressure is 55/32 mmHg, and the pulmonary artery occlusion pressure is 28 mmHg. What is your interpretation?. 4. Would you want additional information? Explain.. 5. What is your treatment?. II. Choice of anesthetic agents. 1. Is ketamine appropriate for induction? Explain.. 2. What is your choice for induction? Explain.. 3. What is your choice for maintenance? Give reasons.. 4. How do you control hypertension at the time of clamping?. 5. Does heart failure or renal insufficiency affect your selection of agents? Explain.. III. Management of muscle relaxation. 1. Is atracurium an appropriate muscle relaxant in this patient? Explain.. No. Atracurium is intermediate-acting, and is not significantly metabolized by the kidneys or the liver, as it is ...
Buy Gene Expression Profiling by Microarrays by Wolf Karsten Hofmann (9780521853965) from Boomerang Books, Australias Online Independent Bookstore
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General anesthesia is a drug-induced reversible state where neuromuscular blockade (NMB), hypnosis, and analgesia (jointly denoted by depth of anesthesia - DoA) are guaranteed. This thesis concerns mathematical modeling and feedback control of the effect of the muscle relaxants atracurium and rocuronium, the hypnotic propofol, and the analgesic remifentanil. It is motivated by the need to reduce incidences of awareness and overdose-related post-operative complications that occur in standard clinical practice. A major challenge for identification in closed-loop is the poor excitation provided by the feedback signal. This applies to the case of drugs administered in closed-loop. As a result, the standard models for the effect of anesthetics appear to be over-parameterized. This deteriorates the result of system identification and prevents individualized control.. In the first part of the thesis, minimally parameterized models for the single-input single-output NMB and the multiple-input ...
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Dave Grohl was really easy to talk to and I liked hanging out in the studio with him, I got to play on a track on their record and Pat Smear their guitarist gave me a ...
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Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
PubMed comprises more than 27 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
D.A. Bardwell, C.S. Adjiman, Y.A. Arnautova, E. Bartashevich, S.X.M. Boerrigter, D.E. Braun, A.J. Cruz-Cabeza, G.M. Day, R.G. Della Valle, G.R. Desiraju, B.P. van Eijck, J.C. Facelli, M.B. Ferraro, D. Grillo, M. Habgood, D.W.M. Hofmann, F. Hofmann, K.V.J. Jose, P.G. Karamertzanis, A.V. Kazantsev, J. Kendrick, L.N. Kuleshova, F.J.J. Leusen, A.V. Maleev, A.J. Misquitta, S. Mohamed, R.J. Needs, M.A. Neumann, D. Nikylov, A.M. Orendt, R. Pal, C.C. Pantelides, C.J. Pickard, L.S. Price, S.L. Price, H.A. Scheraga, J. van de Streek, T.S. Thakur, S. Tiwari, E. Venuti, I.K. ...
The stunning new building at St. Michael, which is at least 10 times the size of the old building, is a musicians dream: traditional cruciform plan, all hard surfaces (no carpet), organ and choir high at the west end of the nave. Our work involved moving the parishs old organ to the new building, separating the pipes into two sections to fit around the new window, building new enclosures and oak casework, rebuilding the console to conform more closely to AGO standards, adding several ranks of pipes, and rescaling and revoicing the old pipes to suit the new location and acoustics.. Traditions and experience have their own value. The organ in St. Michaels old building, by Herman Boettcher & Sons, showed the same fine attention to woodworking detail, use of quality new components, and clever and economical reuse of old material as some of the organs of Otto Hofmann, one of my mentors and models. Mr. Hofmann, a peer of Mr. Boettcher and a founding member and past president of the International ...
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I suppose what I was afraid of was that the sleek monumentality of such a book as a Collected Poems would somehow countermand and extinguish the scrappiness, the impurity, the profane improvisatoriness (the wax flowers, the trick with the river, the medias res of the embalmed corpse) of what seems to me Lowells greatest and most living work. That the fascinating equivocation between process and product, between hard and soft, would be upset. That this particular open book, so long in the making, would no longer provide the insect with any sort of bearable habitat.. The Collected Poems is a large and handsome production, especially where the page layout is concerned. Its pale Cambridge blue jacket is rather unexpected, and the Life Studies-era photograph of a slightly worried-looking Lowell in preppy clothes - collar and tie and sleeveless sweater - twisted half-upright in what looks like a deckchair, against a background of slumped books on shelves, sends the wrong message to, as it were, a ...
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TY - JOUR. T1 - Measurement of the total hadronic cross section in tagged reactions. AU - Aihara, H.. AU - Alston-Garnjost, M.. AU - Avery, R. E.. AU - Barker, A. R.. AU - Bauer, D. A.. AU - Bay, A.. AU - Belcinski, R.. AU - Bingham, H. H.. AU - Bloom, E. D.. AU - Buchanan, C. D.. AU - Caldwell, D. O.. AU - Chao, H. Y.. AU - Chun, S. B.. AU - Clark, A. R.. AU - Cowan, G. D.. AU - Crane, D. A.. AU - Dahl, O. I.. AU - Daoudi, M.. AU - Derby, K. A.. AU - Eastman, J. J.. AU - Eberhard, P. H.. AU - Edberg, T. K.. AU - Eisner, A. M.. AU - Erne, F. C.. AU - Fairfield, K. H.. AU - Fridman, A.. AU - Godfrey, G.. AU - Hauptman, J. M.. AU - Ho, C.. AU - Hofmann, W.. AU - Kamae, T.. AU - Kenney, R. W.. AU - Khacheryan, S.. AU - Kofler, R. R.. AU - Lambert, D. J.. AU - Langeveld, W. G J. AU - Layter, J. G.. AU - Lin, W. T.. AU - Linde, F. L.. AU - Loken, S. C.. AU - Lu, A.. AU - Lynch, G. R.. AU - Lys, J. E.. AU - Madaras, R. J.. AU - Magnuson, B. D.. AU - Marsiske, H.. AU - Masek, G. E.. AU - Mathis, L. ...
Mataix-Cols, D., De La Cruz, L. F., Monzani, B., Rosenfield, D., Andersson, E., Pérez-Vigil, A., Frumento, P., De Kleine, R. A., Difede, J. A., Dunlop, B. W., Farrell, L. J., Geller, D., Gerardi, M., Guastella, A. J., Hofmann, S. G., Hendriks, G. J., Kushner, M. G., Lee, F. S., Lenze, E. J., Levinson, C. A. & 21 others, McConnell, H., Otto, M. W., Plag, J., Pollack, M. H., Ressler, K. J., Rodebaugh, T. L., Rothbaum, B. O., Scheeringa, M. S., Siewert-Siegmund, A., Smits, J. A. J., Storch, E. A., Ströhle, A., Tart, C. D., Tolin, D. F., Van Minnen, A., Waters, A. M., Weems, C. F., Wilhelm, S., Wyka, K., Davis, M. & Rück, C., May 2017, In : JAMA psychiatry. 74, 5, p. 501-510 10 p.. Research output: Contribution to journal › Review article ...
Ucar, A.; Gupta, S. K.; Fiedler, J.; Erikci, E.; Kardasinski, M.; Batkai, S.; Dangwal, S.; Kumarswarmy, R.; Bang, C.; Holzmann, A. et al.; Remke, J.; Caprio, M.; Jentzsch, C.; Engelhardt, S.; Geisendorf, S.; Glas, C.; Hofmann, T. G.; Nessling, M.; Richter, K.; Schiffer, M.; Carrier, L.; Napp, L. C.; Bauersachs, J.; Chowdhury, K.; Thum, T.: The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nature Communications 3, 1078 (2012 ...
Ucar, A.; Gupta, S. K.; Fiedler, J.; Erikci, E.; Kardasinski, M.; Batkai, S.; Dangwal, S.; Kumarswarmy, R.; Bang, C.; Holzmann, A. et al.; Remke, J.; Caprio, M.; Jentzsch, C.; Engelhardt, S.; Geisendorf, S.; Glas, C.; Hofmann, T. G.; Nessling, M.; Richter, K.; Schiffer, M.; Carrier, L.; Napp, L. C.; Bauersachs, J.; Chowdhury, K.; Thum, T.: The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nature Communications 3 (2012 ...
Sansone, S.A., Rocca-Serra, P., Field, D., Maguire, E., Taylor, C., Hofmann, O., Fang, H., Neumann, S., Tong, W., Amaral-Zettler, L., Begley, K., Booth, T., Bougueleret, L., Burns, G., Chapman, B., Clark, T., Coleman, L.A., Copeland, J., Das, S., de Daruvar, A., de Matos, P., Dix, I., Edmunds, S., Evelo, C.T., Forster, M.J., Gaudet, P., Gilbert, J., Goble, C., Griffin, J.L., Jacob, D., Kleinjans, J. Harland, L., Haug, K., Hermjakob, H., Ho Sui, S.J., Laederach, A., Liang, S., Marshall, S., McGrath, A., Merrill, E., Reilly, D., Roux, M., Shamu, C.E., Shang, C.A., Steinbeck, C., Trefethen, A., Williams-Jones, B., Wolstencroft, K., Xenarios, I., and Hide, W. (2012) Toward interoperable bioscience data. Nat Genet. 44:121-126. doi:10.1038/ng.1054 PMID:22281772 PMCID:PMC3428019 ...
Dall, P.; Hekele, A.; Ikenberg, H.; Göppinger, A.; Bauknecht, T.; Pfleiderer, A.; Moll, J.; Hofmann, M.; Ponta, H.; Herrlich, P ...
McMaster, M. L., Berndt, S. I., Zhang, J., Slager, S. L., Li, S. A., Vajdic, C. M., Smedby, K. E., Yan, H., Birmann, B. M., Brown, E. E., Smith, A., Kleinstern, G., Fansler, M. M., Mayr, C., Zhu, B., Chung, C. C., Park, J. H., Burdette, L., Hicks, B. D., Hutchinson, A. & 61 others, Teras, L. R., Adami, H. O., Bracci, P. M., McKay, J., Monnereau, A., Link, B. K., Vermeulen, R. C. H., Ansell, S. M., Maria, A., Diver, W. R., Melbye, M., Ojesina, A. I., Kraft, P., Boffetta, P., Clavel, J., Giovannucci, E., Besson, C. M., Canzian, F., Travis, R. C., Vineis, P., Weiderpass, E., Montalvan, R., Wang, Z., Yeager, M., Becker, N., Benavente, Y., Brennan, P., Foretova, L., Maynadie, M., Nieters, A., de Sanjose, S., Staines, A., Conde, L., Riby, J., Glimelius, B., Hjalgrim, H., Pradhan, N., Feldman, A. L., Novak, A. J., Lawrence, C., Bassig, B. A., Lan, Q., Zheng, T., North, K. E., Tinker, L. F., Cozen, W., Severson, R. K., Hofmann, J. N., Zhang, Y., Jackson, R. D., Morton, L. M., Purdue, M. P., Chatterjee, ...
Gaia Collaboration; Brown, A. G. A. et al. (inc. Bernstein, H. -H.; Stampa, U.; Sagristà Sellés, T.; Mantelet, G.; Löffler, W.; Lenhardt, H.; Hofmann, W.; Brüsemeister, T.; Jordan, S.; Hauser, M.; Altmann, M.; Mercier, E.; Els, S. G.; Grebel, E. K.; Biermann, M.; Bastian, U. ...
IN BRIEF: Nancy R. Hofmann [email protected] Plant development and responses to the environment hinge on the ability to target proteins to different areas…
In February 2017, Jennifer Hofmann, HR staff member at Sonova travelled to Blantyre, Malawi, as a Hear The World volunteer. The aim of her trip was to train the new clinic manager, Mirriam, in a variety of computer programs, answer questions about clinic
Fenske S, Mader R, Scharr A, Paparizos C, Cao-Ehlker X, Michalakis S, Shaltiel L, Weidinger M, Stieber J, Feil S, Feil R, Hofmann F, Wahl-Schott C, Biel M. HCN3 contributes to the ventricular action potential waveform in the murine heart. Circ Res 109:1015-1023, 2011 ...
SIR FREDERICK ABEL (1827-1902), English chemist, was born in London on the 17th of July 1827. After studying chemistry for six years under A. W. von Hofmann at the Royal College of Chemistry (established in London in 1845), he became professor of chemistry at the Royal Military Academy in 1851, and three years later was appointed chemist to the War Department and chemical referee to the government. During his tenure of this office, which lasted until 1888, he carried out a large amount of work in connexion with the chemistry of explosives.. ...
Braig M, Pällmann N, Preukschas M, Steinemann D, Hofmann W, Gompf A, Streichert T, Braunschweig T, Copland M, Rudolph KL, Bokemeyer C, Koschmieder S, Schuppert A, Balabanov S, Brümmendorf ...
The only realistic way to attack the problem of how to predict effects in the future is to understand the present. Accordingly, we focus on a specific problem at a specific site to see how well we can "put it all together". As an example, let us imagine compiling our "best" assessment of the biology of the individual life stages of a given species of, say a copepod. Let us further construct the "best" model of the transport phenomena (advection plus mixing) at a site of limited extent, perhaps a coastal site. Then, given the observed physical forcing(s) plus the observed level(s) of predators upon the copepod stages (and prey items in the copepod diet) can we make a prediction about the concentration and distribution of the copepod population as the individuals progress through their life history? Recent work of this kind in the South Atlantic Bight (Hofmann, 1988) suggests that, so long as the time horizon is not too long, we may be closer to this specific goal than ever before.. Such attempts ...
Jimcor Agencies has appointed Christopher Hofmann to the position of branch manager of the Plymouth Meeting, Penn., office.Hofman brings with him over 15
Voglreiter, P., Hofmann, M., Ebner, C., Schmalstieg, D., Sequeiros, R. B., Portugaller, H. R., Fuetterer, J., Moche, M. & Steinberger, M., 1 Sep 2016, Proceedings EUROGRAPHICS Workshop on Visual Computing in Biology and Medicine (VCBM). Bergen, Norway: Eurographics - European Association for Computer Graphics. Publikation: Beitrag in Buch/Bericht/Konferenzband › Beitrag in einem Konferenzband ...
Dolan, Eimear B.; Hofmann, Björn; de Vaal, M. Hamman; Bellavia, Gabriella; Straino, Stefania; Kovarova, Lenka; Pravda, Martin; Velebny, Vladimir; Daro, Dorothee; Braun, Nathalie; Monahan, David S.; Levey, Ruth E.; ONeill, Hugh; Hinderer, Svenja; Greensmith, Robert; Monaghan, Michael G.; Schenke-Layland, Katja; Dockery, Peter; Murphy, Bruce P.; Kelly, Helena M.; Wildhirt, Stephen; Duffy, Garry P. (Elsevier, 2019-05-15) ...
Angelika Bierhaus, Stephan Schiekofer, Markus Schwaninger, Martin Andrassy, Per M. Humpert, Jiang Chen, Mei Hong, Thomas Luther, Thomas Henle, Ingrid Klöting, Michael Morcos, Marion Hofmann, Hans Tritschler, Bernd Weigle, Michael Kasper, Mark Smith, George Perry, Ann-Marie Schmidt, David M. Stern, Hans-Ulrich Häring, Erwin Schleicher and Peter P. Nawroth ...
Naumann N, Schwaab J, Metzgeroth G, Jawhar M, Haferlach C, Göhring G, Schlegelberger B, Dietz CT, Schnittger S, Lotfi S, Gärtner M, Dang TA, Hofmann WK, Cross NC, Reiter A, Fabarius ...
P. Mair, E. Hofmann, K. Gruber, R. Hatzinger & A. Zeileis (2015). Motivation, Values, and Work Design as Drivers of Participation in the R Open Source Project. Proceedings of the National Academy of Sciences of the United States of Ame, 112 (48), 14788. doi: 10.1073/pnas.1506047112 [go to publishers site] ...
A gang of obviously very clever people have discovered a rare new element to stand proudly alongside Hydrogen, Barium and Krypton. Now, it needs a name. Sigurd Hofmann (one of the few newsworthy people youll see named
Bröker, B.; Hofmann, O. T.; Rangger, G. M.; Frank, P.; Blum, R. P.; Rieger, R.; Venema, L.; Vollmer, A.; Müllen, K.; Rabe, J. P. et al.; Winkler, A.; Rudolf, P.; Zojer, E.; Koch, N.: Density-Dependent Reorientation and Rehybridization of Chemisorbed Conjugated Molecules for Controlling Interface Electronic Structure. Physical Review Letters 104 (24), 246805 (2010 ...
Ludwig M. Heindl; Tanja N. Hofmann; Harald L. J. Knorr; Carmen Rummelt; Falk Schrödl; Ursula Schlötzer-Schrehardt; Leonard M. Holbach; Gottfried O. H. Naumann; Friedrich E. Kruse; Claus ...
Import Export (2007) review. Director: Ulrich Seidl. Starring: Ekateryna Rak, Paul Hofmann, Michael Thomas, Natalja Epureanu, Brigitte Kren, Lidiya Oleksandrivna Savka, Petra Morzé, Georg Friedrich, Peter Linduska, Christina York
Altered neuronal responses and regulation of neurotrophic proteins in the medial septum following fimbria-fornix transection in CNTF- and LIF-deficient mice. Eur J Neurosci 24:2223-2232. Schubert KO, Naumann T, Schnell O, Zhi Q, Steup A, Hofmann H-D, Kirsch M (2005 ...
1. Abarenkov, K.; Adams, R.I.; Irinyi, L.; Agan, A.; Ambrosio, E.; Antonelli, A.; Bahram, M.; Bengtsson-Palme, J.; Bok, G.; Cangren, P.; Coimbra, V.; Coleine, C.; Gustafsson, C.; He, J.; Hofmann, T.; Kristiansson, E.; Larsson, E.; Larsson, T.; Liu, Y.; Martinsson, S. ... Nilsson, R.H. (2016). Annotating public fungal ITS sequences from the built environment according to the MIxS-Built Environment standard - a report from a May 23-24, 2016 workshop (Gothenburg, Sweden). MycoKeys, 16, 1−15, 10.3897/mycokeys.16.10000.. 2. Abdalla, Mohamed; Hastings, Astley; Truu, Jaak; Espenberg, Mikk; Mander, Ülo; Smith, Pete (2016). Emissions of methane from northern peatlands: a review of management impacts and implications for future management options. Ecology and Evolution, 1−23, ece3.2469.. 3. Andréassian, Vazken; Mander, Ülo; Pae, Taavi (2016). The Budyko hypothesis before Budyko: The hydrological legacy of Evald Oldekop. Journal of Hydrology, 535, 386−391, 10.1016/j.jhydrol.2016.02.002.. 4. Angel ...
Do You Want To Burn Fat And Build Muscle? Discover How To Get In The Best Shape Of Your Life Without Ever Stepping Foot Into A Gym... Are you looking to
en] BACKGROUND AND OBJECTIVE: Residual muscle paralysis remains a concern for anaesthesiologists. This study investigated the recovery from neuromuscular block (NMB) after an intubation dose of cisatracurium (C) or rocuronium (R) in 32 patients undergoing lumbar disc surgery. METHODS: Anaesthesia was induced with propofol and sufentanil, and maintained with sevoflurane in nitrous oxide/oxygen. Patients were randomised to receive twice the ED95 of either cisatracurium (GC) or rocuronium (GR) before tracheal intubation. After placement in prone position, neuromuscular transmission was monitored at the wrist by accelerometry. NMB was antagonised when the TOF ratio (TOFR) was , 0.75 at muscle closure. The time from muscle relaxant to muscle closure, and to TOFR of 0.25 and of 0.50 were recorded. Data were analysed using Students t-tests, chi-squared tests and two-way mixed-designed ANOVAs. The prediction probability (Pk) of the times from muscle relaxant to muscle closure, and to TOFR of 0.25 for ...
Cadila Pharmaceuticals is a one of the foremost pharma companies in synthesizing APIs. We are bulk drug manufacturer of Amlodipine Besylate. The CAS number of Amlodipine Besylate is 88150-42-9.. Amlodipine is used to treat high blood pressure. Lowering high blood pressure helps to prevent heart attack, strokes and kidney problems. Amlodipine Besylate is a calcium channel blocker drug. It relaxes blood vessels so blood can flow easily. It is also used to prevent certain types of chest pain.. Cadila Pharmaceuticals Limited is one of the top USFDA approved pharmaceutical companies based in India. It is respected as a best Active Pharmaceutical Ingredients (APIs) manufacturing company in India. One of our core expertises is to synthesize APIs of the highest quality at inexpensive price.. We are major Amlodipine Besylate manufacturer and supplier. We export Amlodipine Besylate to Asian countries like; Japan, China, Georgia, Singapore, Malaysia, Vietnam, South Korea etc., and Middle East countries ...
Gantacurium chloride (formerly recognized as GW280430A and as AV430A) is a new experimental neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Gantacurium is not yet available for widespread clinical use: it is currently undergoing Phase III clinical development. Gantacurium represents the third generation of tetrahydroisoquinolinium (THIQ) neuromuscular blocking drugs in a long lineage of compounds invented by medicinal chemists and scientists at Burroughs Wellcome Co., Research Triangle Park, North Carolina. Unlike all other clinically used tetrahydroisoquinolinium agents except cisatracurium, gantacurium is a stereo- and regioselective single isomer. And unlike any other traditional symmetrical predecessors in the family of bisbenzyltetrahydroisoquinolinium ...
This is a multicenter, randomized, controlled, observer-blinded, dose-response study to evaluate the efficacy in tracheal intubation and safety of gantacurium chloride for injection in healthy adult patients undergoing surgery with general anesthesia.. Gantacurium chloride for injection (previously referred to as AV430A) is a new, investigational non-depolarizing ultra-short acting neuromuscular blocking agent (NMB). Preliminary results in animals and healthy human subjects (Phase 1 studies in adult volunteers) suggest that gantacurium chloride for injection may provide a useful adjunct to general anesthesia by permitting rapid intubation. This Phase 2 study will provide more definitive information on the ultra-short acting profile of the compound by determining the quality of intubation in patients, at 60 seconds, as assessed by a blinded intubator. In addition, the safety of the compound will be assessed. In this study, the efficacy and safety of gantacurium chloride for injection will also be ...
Patient Information Amlodipine Besylate and Benazepril Hydrochloride Capsules, 2.5 mg/10 mg, 5 mg/10 mg, 5 mg/20 mg, 10 mg/20 mg Read this Patient Information leaflet before you start taking amlodipine besylate and benazepril hydrochloride capsules and each time you get a refill. There may be new information. This leaflet does not replace talking with your doctor. If you have any questions, ask your doctor or pharmacist.. What is the most important information I should know about amlodipine besylate and benazepril hydrochloride capsules? Amlodipine besylate and benazepril hydrochloride capsules can harm an unborn baby and even cause death. If you get pregnant, stop taking amlodipine besylate and benazepril hydrochloride capsules. Call your doctor right away. Talk to your doctor about other ways to lower your blood pressure if you plan to become pregnant.. What is amlodipine besylate and benazepril hydrochloride capsules? Amlodipine besylate and benazepril hydrochloride capsules contains two ...
The Chugaev Reaction: Harold R. Synthesis of Peptides with Mixed Anhydrides: Noel F. Desulfurization with Raney Nickel: George R. The Beckmann Rearrangement: L. The Demjanov and Tiffeneau-Demjanov Ring oxazoles: Peter A. Arylation of Unsaturated Compounds by Diazonium Salts: Christian S. The Favorskii download Progress in Wall Turbulence: Understanding and Modeling: Proceedings of the WALLTURB International Workshop held in Lille, France, April 21 23, 2009 2011 of Haloketones: Andrew S. Olefins from Amines: The Hofmann Elimination Reaction and Amine Oxide Pyrolysis: Arthur C. The Coupling of Diazonium Salts with Aliphatic Carbon Atoms: Stanley J. The Japp-Klingemann Reaction: Robert R. The Michael Reaction: Ernst D. The home of geostrategic people with Sodium Amide: K. The Gattermann Synthesis of Aldehydes: William E. The Baeyer-Villiger Oxidation of Aldehydes and Ketones: C. The Alkylation of Esters and Nitriles: Arthur C. The way of Halogens with Silver Salts of Carboxylic Acids: C. The Pschorr
Cetirizine was not mutagenic in the Ames test, and not clastogenic in the human lymphocyte assay, the mouse lymphoma assay, and in vivo micronucleus test in rats Label. Jump to section. Cetirizine may decrease the excretion rate of Allopurinol which could result in a higher serum level. The risk or severity of adverse effects can be increased when Cetirizine is combined with Atracurium besylate. Cetirizine may decrease the excretion rate of Ixazomib which could result in a higher serum level. Carboplatin may decrease the excretion rate of Cetirizine which could result in a higher serum level.. ...
Présentations du médicament AMLODIPINE ALMUS. AMLODIPINE ALMUS 5 mg: gélule ; boîte de Sur ordonnance (Liste I) - Remboursable à 65 % - Prix: 4,82 €. AMLODIPINE ALMUS 5 mg: gélule ; boîte de Sur ordonnance (Liste I) - Remboursable à 65 % - Prix: 13,45 €. AMLODIPINE ALMUS AMLODIPINE MYLAN (Inhibiteur calcique): fiche médicament du Vidal de la famille précisant la composition, la posologie, les interactions possibles, les effets indésirables éventuels.. Am or pm suspensie amlodipine lijek besy 5mg a ace hemmer. Besylate kidneys side effects exists side effects of coming off norvasc treatment cancer dosage for dogs. Besylate hypothyroid positive effects amlodipine amlodipine 5 mg eureka mg ingredients 10 mg eureka besylate off label use. Besylate uneconomical buy without prescription using. Amlodipine Cor Vidal. Amlodipine is needed to treat hypertension (high blood pressure) and to work angina (chest cane). Amlodipine may also be used for amlodipine 5 mg eureka other ...
Was taking Atenolol for about 10 years then around 3 years ago started on Amlodipine Besylate about ... over 184/90 to116/69 pulse 120 at rest to 54,reduced Amlodipine to 0 over a week BP now more stable ...
Listing your company for AMLODIPINE BESYLATE allows buyers to find your information through our directory pages which appear in the top positions when a search is conducted in Google, Yahoo!, MSN etc ...
... (marketed by King Pharmaceuticals under the brand name Skelaxin) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. Skelaxin is available in an 800 mg scored tablet. Possible side effects include nausea, vomiting, drowsiness and CNS side effects, such as dizziness, headache, and irritability. The metabolism of metaxalone involves the liver cytochrome P450 system. Based on the information in the labeling, patients receiving metaxalone therapy and physicians prescribing metaxalone are directed to take precaution when coadministering it with other medications involving the P450 system.[1][2] Because of potential for side effects, this drug is considered high risk in the elderly. As of 2015[update] the ...
While botulinum toxin is generally considered safe in a clinical setting, there can be serious side effects from its use. The use of botulinum toxin A in cerebral palsy children is safe in the upper and lower limb muscles.[5][6] Most commonly, botulinum toxin can be injected into the wrong muscle group or with time spread from the injection site, causing temporary paralysis of unintended muscles. Side effects from cosmetic use generally result from unintended paralysis of facial muscles. These include partial facial paralysis, muscle weakness, and trouble swallowing. Side effects are not limited to direct paralysis however, and can also include headaches, flu-like symptoms, and allergic reactions.[41] Just as cosmetic treatments only last a number of months, paralysis side-effects can have the same durations.[citation needed] At least in some cases, these effects are reported to dissipate in the weeks after treatment.[citation needed] Bruising at the site of injection is not a side effect of the ...
... is a centrally acting muscle relaxant. It can be used as an antidote for strychnine poisoning. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index. It is especially dangerous and potentially fatal in combination with alcohol and other depressants.[1] Mephenesin was used by Bernard Ludwig and Frank Berger to synthesize meprobamate, the first tranquilizer to see widespread clinical use. Mephenesin is no longer available in North America but is used in France, Italy and a few other countries.[2] Its use has largely been replaced by the related drug methocarbamol, which is better absorbed.[3] Mephenesin may be an NMDA receptor antagonist.[4] ...
Because of the enhancement of inhibition in the CNS, most spasmolytic agents have the side effects of sedation, drowsiness and may cause dependence with long-term use. Several of these agents also have abuse potential, and their prescription is strictly controlled.[22][23][24] The benzodiazepines, such as diazepam, interact with the GABAA receptor in the central nervous system. While it can be used in patients with muscle spasm of almost any origin, it produces sedation in most individuals at the doses required to reduce muscle tone.[5] Baclofen is considered to be at least as effective as diazepam in reducing spasticity, and causes much less sedation. It acts as a GABA agonist at GABAB receptors in the brain and spinal cord, resulting in hyperpolarization of neurons expressing this receptor, most likely due to increased potassium ion conductance. Baclofen also inhibits neural function presynaptically, by reducing calcium ion influx, and thereby reducing the release of excitatory ...
Atracurium. *Barbiturates (e.g., pentobarbital, sodium thiopental). *BNC-210. *Bungarotoxins (e.g., α-bungarotoxin, κ- ...
The usual dose of 350 mg is unlikely to engender prominent side effects other than somnolence, and mild to significant euphoria or dysphoria, but the euphoria is generally short-lived due to the fast metabolism of carisoprodol into meprobamate and other metabolites; the euphoria derived is, according to new research, most likely due to carisoprodol's inherent, potent anxiolytic effects that are far stronger than those produced by its primary metabolite, meprobamate, which is often misblamed for the drug-seeking associated with carisoprodol, as carisoprodol itself is responsible for the significantly more intense CNS effects than meprobamate alone. Carisoprodol has a unique mechanism of action, qualitatively different from that of meprobamate (Miltown). The medication is well-tolerated and without adverse effects in the majority of patients for whom it is indicated. In some patients, however, and/or early in therapy, carisoprodol can have the full spectrum of sedative side effects and can impair ...
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
... atracurium. Atracurium itself was invented at Strathclyde University and licensed to Burroughs Wellcome Co., Research Triangle ... Unlike the parent, atracurium, cisatracurium affords a much better pharmacological profile with respect to eliciting histamine ... To address this issue, a program was initiated to investigate the individual isomer constituents of atracurium to identify and ... Stiller RL, Cook DR, Chakravorti S (1985). "In vitro degradation of atracurium in human plasma". Br J Anaesth. 57 (11): 1085- ...
Fodale V, Santamaria LB (July 2002). "Laudanosine, an atracurium and cisatracurium metabolite". Eur J Anaesthesiol. 19 (7): 466 ... Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite of atracurium and cisatracurium. Laudanosine decreases ... to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium. ...
The orientation of the two O atoms in the bridge is to the THIQ side of the carbonyl C=O group, whereas in Atracurium the O ... Unlike the potency of the cis-cis isomer of Atracurium (also known as 51W89 and eventually marketed as the drug cisatracurium ... Atracurium's groups are "reversed ester" linkages. This makes ester hydrolysis degradation by plasma cholinesterase more ... Having ten methoxy -OCH3 groups, mivacurium is a more potent neuromuscular blocking drug than Atracurium, which has eight, but ...
... may increase the neuromuscular blocking activities of atracurium besilate. "chlortetracycline , C22H23ClN2O8 ...
... atracurium, and cisatracurium. Succinylcholine is a widely used muscle relaxant drug which acts by activating, instead of ...
"Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium". Anesth Analg. 80: 1007- ...
Anaphylaxis Non-depolarizing Muscle Relaxants Histamine release e.g. Atracurium & Mivacurium Anaphylaxis Another potentially ... Decamethonium Non-depolarizing muscle relaxants Short acting Mivacurium Rapacuronium Intermediate acting Atracurium ...
Thus if full sedation alone is ineffective, patients may be paralyzed with drugs such as atracurium. Paralysis allows the ...
The nondepolarizing muscle relaxants pancuronium, cisatracurium, atracurium, mivacurium, vecuronium and rocuronium also do not ...
Benzylisoquinolines, such as atracurium and tubocurarine, the other major group of neuromuscular blocking agents Ted Lin; Tim ...
Mouw RJ, Klumper F, Hermans J, Brandenburg HC, Kanhai HH (1999). "Effect of atracurium or pancuronium on the anemic fetus ...
"Comparative evaluation of atracurium dosed on ideal body weight vs. total body weight in morbidly obese patients". British ...
A muscle relaxant such as atracurium would be administered after this, though this would not strictly be a part of coinduction ...
Unlike the pH- and temperature-dependent chemodegradation seen with atracurium and cisatracurium, the inactivation of ... of successful predecessor bistetrahydroisoquinolinium neuromuscular blocking drugs development projects such as atracurium ( ...
The molecular formula C21H27NO4 (molar mass: 357.44 g/mol) may refer to: Laudanosine, a toxic metabolite of atracurium and ...
... atracurium besilate) Treximet (sumatriptan and naproxen sodium) Trimovate (clobetasone butyrate) Trobalt (retigabine) Tykerb ( ...
... atracurium MeSH D03.438.531.085.077 --- bicuculline MeSH D03.438.531.085.666 --- papaverine MeSH D03.438.531.085.666.850 --- ...
... vaccine Tetanus vaccine Tick-borne encephalitis vaccine Typhoid vaccine Varicella vaccine Yellow fever vaccine Atracurium ...
Atracurium besilate/povidone iodine. Anaphylactic reactions and contact allergy: 3 case reports ...
A list of US medications equivalent to Atracurium Besylate-DBL is available on the Drugs.com website. ... Atracurium Besylate-DBL is a medicine available in a number of countries worldwide. ... Ingredient matches for Atracurium Besylate-DBL. Atracurium. Atracurium Besilate is reported as an ingredient of Atracurium ... Atracurium Besylate-DBL. Atracurium Besylate-DBL may be available in the countries listed below. ...
A list of US medications equivalent to Atracurium Besylate Bedford is available on the Drugs.com website. ... Atracurium Besylate Bedford is a medicine available in a number of countries worldwide. ... Ingredient matches for Atracurium Besylate Bedford. Atracurium. Atracurium Besilate is reported as an ingredient of Atracurium ...
Atracurium Besylate Injection: Generic equivalent of Tracrium. New approved drug details including side effects, uses and ... Atracurium Besylate Injection. The following drug information is obtained from various newswires, published medical journal ... Preserved and unpreserved forms of Atracurium Besylate Injection, an intermediate duration muscle relaxant, have been approved ...
Atracurium Besylate) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related ... TRACRIUM Injection, 10 mg atracurium besylate in each mL. 5-mL Single-Use Vial (50 mg atracurium besylate per vial). Tray of 10 ... TRACRIUM (atracurium besylate) Injection is a sterile, nonpyrogenic aqueous solution. Each mL contains 10 mg atracurium ... TRACRIUM (atracurium besylate) should be administered intravenously. DO NOT GIVE TRACRIUM (atracurium besylate) BY ...
Patient information for ATRACURIUM BESILATE 10MG/ML SOLUTION FOR INJECTION Including dosage instructions and possible side ... ATRACURIUM BESILATE 10MG/ML SOLUTION FOR INJECTION. Active substance(s): ATRACURIUM BESILATE / ATRACURIUM BESILATE / ATRACURIUM ... Atracurium Hospira 10 mg/ml, solution injectable. Ireland. Atracurium Besilate 10 mg/ml Solution for Injection. Portugal. ... Atracurium Hospira 10 mg/ml, solution injectable. Ireland. Atracurium Besilate 10 mg/ml Solution for Injection. Portugal. ...
Atracurium Besylate Injection official prescribing information for healthcare professionals. Includes: indications, dosage, ... How is Atracurium Besylate Injection Supplied. Atracurium Besylate Injection, USP, each mL containing 10 mg atracurium besylate ... No atracurium dosage adjustments are required for patients with renal disease.. An initial atracurium besylate dose of 0.3 to ... Atracurium is potentiated by isoflurane or enflurane anesthesia. The same initial atracurium besylate dose of 0.4 to 0.5 mg/kg ...
Dewar first named this compound "33A74" before its eventual emergence in the clinic as atracurium. Atracurium was the ... and came to be known as atracurium. "Atracurium Besylate". The American Society of Health-System Pharmacists. Archived from the ... Atracurium is available as a generic medication. The wholesale cost in the developing world is about 1.69 to 1.87 USD per dose ... Atracurium is in the neuromuscular-blocker family of medications and is of the non-depolarizing type. It works by blocking the ...
Atracurium should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in ... Atracurium. Drug Summary. 1996 Full text (in our servers) *Spigset O. Anaesthetic agents and excretion in breast milk. Acta ... Pharmacokinetics of atracurium besylate in healthy patients (after a single i.v. bolus dose). Br J Anaesth. 1983 Abstract ... Atracurium should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in ...
Atracurium is classified as an intermediate-duration non-depolarizing neuromuscular-blocking agent. ... Atracurium besylate[1] is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing ... This may occur if atracurium is injected immediately after thiopentone. Respiratory effects In standard doses, atracurium ... Histamine release may occur with doses of atracurium greater than 0.6 mg/kg. Histamine may also be released if atracurium ...
Atracurium besilate/thiopental sodium. Hand oedema and cyanosis following accidental arterial injection: case report ...
DYNAMICS OF ATRACURIUM INFUSION You will receive an email whenever this article is corrected, updated, or cited in the ... J. Ebert, J. Proctor; DYNAMICS OF ATRACURIUM INFUSION. Anesthesiology 1984;61(3):A292. ...
atracurium ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
Atracurium besylate Density MSDS Formula Use,If You also need to Atracurium besylate Other information,welcome to contact us. ... ChemicalBook provide Chemical industry users with Atracurium besylate Boiling point Melting point, ... Atracurium Dibesylate;Tracur;Wellcome 33A74;ATRACURIUM BESILATE;ATRACURIUM BESYLATE. ... Atracurium besylate Usage And Synthesis. Skeletal muscle relaxant for anesthesia. Atracurium Besilate is a kind of skeletal ...
Unlike atracurium and five other available component isomers in the atracurium mixture, cisatracurium does not produce ... One was equipotent and the three "R-series" isomers were more potent than atracurium. All six isomers and atracurium were ... Bolus intravenous administration of each of the five isomers of atracurium and atracurium itself produced decreases in arterial ... of the atracurium mixture, as a neuromuscular blocking agent that was 1.5 times more potent than atracurium, had neuromuscular ...
Neuromuscular Effects of Atracurium in Infants and Children N. Goudsouzian, M.D.; L. M. P. Liu, M.D.; M. Gionfriddo, B.A.; G. D ... Neuromuscular Effects of Atracurium in Infants and Children You will receive an email whenever this article is corrected, ... Neuromuscular Effects of Atracurium in Infants and Children. Anesthesiology 1 1985, Vol.62, 75-79. doi: ... N. Goudsouzian, L. M. P. Liu, M. Gionfriddo, G. D. Rudd; Neuromuscular Effects of Atracurium in Infants and Children. ...
... experienced further anaphylaxis on reexposure to atracurium despite negative skin tests to atracurium. Anaphylaxis to NMBD ... Third, one of these patients (patient 9) with negative skin tests had systemic mastocytosis and received atracurium. In this ... Anaphylaxis Incidence with Rocuronium, Succinylcholine, and Atracurium: How Risk Communication Can Influence Behavior. ... Pascale Dewachter, Claudie Mouton-Faivre; Anaphylaxis Incidence with Rocuronium, Succinylcholine, and Atracurium: How Risk ...
The generic ingredient in ATRACURIUM BESYLATE PRESERVATIVE FREE is atracurium besylate. There are sixteen drug master file ... NDA 074633 describes ATRACURIUM BESYLATE PRESERVATIVE FREE, which is a drug marketed by Aurobindo Pharma Ltd, Baxter Hlthcare, ... Additional details are available on the ATRACURIUM BESYLATE PRESERVATIVE FREE profile page. ...
Importance of the Level of Paralysis Recovery for a Rapid Antagonism of Atracurium Meeting Abstracts with Moderate Doses of ... Importance of the Level of Paralysis Recovery for a Rapid Antagonism of Atracurium Meeting Abstracts with Moderate Doses of ... Importance of the Level of Paralysis Recovery for a Rapid Antagonism of Atracurium Meeting Abstracts with Moderate Doses of ... Importance of the Level of Paralysis Recovery for a Rapid Antagonism of Atracurium Meeting Abstracts with Moderate Doses of ...
Atracurium and vecuronium caused a 100% depression of the TH of the adductor pollicis and geniohyoid muscle. No significant ... The return of the T4 0.7 of the thumb was achieved at 54 plus/minus 8 and 52 plus/minus 11 min after atracurium and vecuronium ... In one patient receiving atracurium, the recovery of the TH90 of the geniohyoid was delayed by 8 min as compared to that of the ... A singe dose of 0.5 mg *symbol* kg sup -1 atracurium was administered intravenously over 20 s to eight patients, and 0.1 mg * ...
... in the atracurium and cisatracurium groups, respectively (P = .72). ICU length or stay was 18 d (IQR 8-34 d) in the atracurium ... 166 for atracurium (data for atracurium and cisatracurium from Lexicomp Online, Lexi-Drugs, www.lexi.com, Accessed December 2, ... Comparison of Cisatracurium Versus Atracurium in Early ARDS. Leanne Moore, Charles Joseph Kramer, Sophie Delcoix-Lopes, Ariel M ... Comparison of Cisatracurium Versus Atracurium in Early ARDS. Leanne Moore, Charles Joseph Kramer, Sophie Delcoix-Lopes, Ariel M ...
Systemic Vascular Responses to Atracurium during Enflurane-Nitrous-Oxide Anesthesia in Humans. Anesthesiology 3 1983, Vol.58, ... John C. Hilgenberg, Robert K. Stoelting, William A. Harris; Systemic Vascular Responses to Atracurium during Enflurane-Nitrous- ... Systemic Vascular Responses to Atracurium during Enflurane-Nitrous-Oxide Anesthesia in Humans ... Systemic Vascular Responses to Atracurium during Enflurane-Nitrous-Oxide Anesthesia in Humans ...
The aim of this randomised trial was to assess the effect of urethral infusion of atracurium besylate in dogs and cats with ... Effect of urethral infusion of atracurium besylate on manual bladder expression in dogs and cats with spinal cord injuries: a ... Effect of urethral infusion of atracurium besylate on manual bladder expression in dogs and cats with spinal cord injuries: a ... Urethral infusion of atracurium facilitates manual bladder expression in dogs and cats with urinary retention secondary to ...
In the control group, 2 min after injection of atracurium, plasma histamine levels were 0.76 +/- 0.76 ng/mL, and in the ... Six minutes after the induction of anesthesia with thiopental/fentanyl, patients received atracurium 0.5 mg/kg over 5 s. Plasma ... A prospective, randomized, double-blind study was performed in 40 patients (ASA class I-III) treated with atracurium to ... A prospective, randomized, double-blind study was performed in 40 patients (ASA class I-III) treated with atracurium to ...
... atracurium explanation free. What is atracurium? Meaning of atracurium medical term. What does atracurium mean? ... Looking for online definition of atracurium in the Medical Dictionary? ... atracurium. Also found in: Dictionary, Wikipedia. atracurium. [at″rah-cūr´e-um] a neuromuscular blocking agent of intermediate ... Atracurium , definition of atracurium by Medical dictionary https://medical-dictionary.thefreedictionary.com/atracurium ...
  • Having ten methoxy -OCH3 groups, mivacurium is a more potent neuromuscular blocking drug than Atracurium, which has eight, but is less potent than Doxacurium, which has twelve. (wikipedia.org)
  • In this case, moderate features including hypotension and rash associated with an increased tryptase level and negative skin tests to atracurium rather suggest nonallergic immediate hypersensitivity. (asahq.org)
  • Pharmacokinetics of atracurium during continuous infusion. (springer.com)
  • The aim of this randomised trial was to assess the effect of urethral infusion of atracurium besylate in dogs and cats with signs of urinary retention secondary to lesions affecting spinal cord segments T3-L3. (bmj.com)
  • Animals were subsequently treated in a blinded fashion by the same operator with urethral infusion of 2-4 ml of either a solution of 0.5 mg/ml of atracurium (treatment group) or placebo (control group) and, after five minutes, a second attempt was made to induce bladder emptying by manual compression and a post-treatment score assigned. (bmj.com)
  • Urethral infusion of atracurium facilitates manual bladder expression in dogs and cats with urinary retention secondary to spinal cord injuries. (bmj.com)
  • Atracurium besylate was first synthesized in 1974 by George H. Dewar, [ 2 ] a pharmacist and a medicinal chemistry doctoral candidate in John B. Stenlake's medicinal chemistry research group in the Department of Pharmacy at Strathclyde University , Scotland . (netlibrary.cc)
  • Atracurium ist als Zusatz zur allgemeinen Anästhesie indiziert, um Muskelrelaxation während chirurgischer Eingriffe oder mechanischer Beatmung zu erzeugen und auch die endotracheale Intubation zu erleichtern. (china-sinoway.com)
  • After stabilisation, atracurium 0.4 mg/kg (ATR group, n = 20) or saline 0.04 ml/kg (SAL group, n = 20) was administered intravenously. (1library.net)
  • This study was undertaken to determine the neuromuscular blocking profiles, the effects on the autonomic nervous system, and the potential of atracurium and the six available isomers to produce cardiovascular effects in anesthetized cats. (asahq.org)
  • Bronchospasm has been reported on occasion with the use of atracurium. (wikipedia.org)
  • Assess respiratory status continuously throughout therapy with atracurium. (drugguide.com)
  • Influence of atracurium on selected cardiovascular and respiratory variables and surgical times in dogs undergoing laparoscopic ovariectomy with a standardised ventilation pattern P. Rauser, M. Crha, A. Sivkova, J. Zapletalova, N. Korytarova Small Animal Clinic, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic ABSTRACT: Respiratory and cardiovascular changes in normocapnic dogs undergoing laparoscopic ovariectomy are described in this report. (1library.net)
  • Administration of atracurium in dogs undergoing laparoscopic ovariectomy with a standardised ventilation pattern did not result in clinically important differences in selected cardiovascular and respiratory variables and surgical times in comparison with non-relaxed dogs. (1library.net)