Adenosine Triphosphate
Adenosine Triphosphatases
Endopeptidases
Neprilysin
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Serine Endopeptidases
Thiorphan
PHEX Phosphate Regulating Neutral Endopeptidase
A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
Protease Inhibitors
Cysteine Endopeptidases
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Substrate Specificity
Glycopeptides
Neurotensin
A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.
Lysostaphin
Aspartic Acid Endopeptidases
Base Sequence
Hydrogen-Ion Concentration
Binding Sites
Atrial Natriuretic Factor
Cells, Cultured
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Chromatography, High Pressure Liquid
Peptide Fragments
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Cathepsin B
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
Mutation
Protein Binding
Electrophoresis, Polyacrylamide Gel
Bradykinin
A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Substance P
Cloning, Molecular
Sequence Homology, Amino Acid
Carboxypeptidases
Cell Membrane
Enzyme Activation
Adenosine Diphosphate
Kidney
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Enkephalin, Leucine
ATP Synthetase Complexes
Rabbits
Aminopeptidases
Botulinum Toxins, Type A
Dose-Response Relationship, Drug
Flavobacterium
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Peptide Hydrolases
Thermolysin
Enzyme Inhibitors
Propionates
Protein Processing, Post-Translational
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Cattle
ATP-Dependent Endopeptidases
Phosphorylation
Membrane Proteins
Rats, Sprague-Dawley
Carboxypeptidases A
Carboxypeptidases that are primarily found the DIGESTIVE SYSTEM that catalyze the release of C-terminal amino acids. Carboxypeptidases A have little or no activity for hydrolysis of C-terminal ASPARTIC ACID; GLUTAMIC ACID; ARGININE; LYSINE; or PROLINE. This enzyme requires ZINC as a cofactor and was formerly listed as EC 3.4.2.1 and EC 3.4.12.2.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Transfection
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Amino Acids
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Chromatography, Gel
Angiotensin-Converting Enzyme Inhibitors
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Familial Hypophosphatemic Rickets
Models, Molecular
Peptidyl-Dipeptidase A
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.
Structure-Activity Relationship
Catalysis
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Models, Biological
Isoflurophate
Rats, Wistar
Magnesium
Transcription, Genetic
Leucyl Aminopeptidase
A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Kinins
A generic term used to describe a group of polypeptides with related chemical structures and pharmacological properties that are widely distributed in nature. These peptides are AUTACOIDS that act locally to produce pain, vasodilatation, increased vascular permeability, and the synthesis of prostaglandins. Thus, they comprise a subset of the large number of mediators that contribute to the inflammatory response. (From Goodman and Gilman's The Pharmacologic Basis of Therapeutics, 8th ed, p588)
Receptors, Purinergic P2
Mitochondrial Proton-Translocating ATPases
Cathepsin C
A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.
Aminocaproates
Temperature
Carrier Proteins
Mutagenesis, Site-Directed
Chromatography, Ion Exchange
Blotting, Western
DNA, Complementary
Enzyme Stability
DNA Primers
N-Acetylmuramoyl-L-alanine Amidase
Botulinum Toxins
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Neuropeptides
Cations, Divalent
Monoiodotyrosine
Tachykinins
A family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.
Castor Bean
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Guinea Pigs
Sodium
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Trypsin
Heterocyclic Compounds, 3-Ring
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Edetic Acid
Gene Expression Regulation
Mitochondrial ADP, ATP Translocases
A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.
Cytosol
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Gene Expression
Recombinant Fusion Proteins
Alanine
DNA-Binding Proteins
Cathepsins
Zinc
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Proline
Antigens, CD13
Saccharomyces cerevisiae
Streptomyces griseus
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Endopeptidase K
Promoter Regions, Genetic
Catalytic Domain
Endothelins
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
Tumor Cells, Cultured
Subcellular Fractions
Components of a cell produced by various separation techniques which, though they disrupt the delicate anatomy of a cell, preserve the structure and physiology of its functioning constituents for biochemical and ultrastructural analysis. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p163)
Thymopentin
Kell Blood-Group System
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Biological Transport
Cyclic GMP
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Immunoblotting
Plant Proteins
Peroxisomal proteostasis involves a Lon family protein that functions as protease and chaperone. (1/1)
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ATP-dependent Clp protease adaptor protein ClpS
Endopeptidase Clp Clp protease family Varshavsky A (August 2011). "The N-end rule pathway and regulation by proteolysis". ... the ATP-dependent Clp protease adaptor protein ClpS is a bacterial protein. In the bacterial cytosol, ATP-dependent protein ...
ATP-dependent Clp protease proteolytic subunit
This protein is an essential component to form the protein complex of Clp protease (Endopeptidase Clp). Enzyme ClpP is a highly ... ATP-dependent Clp protease proteolytic subunit (ClpP) is an enzyme that in humans is encoded by the CLPP gene. ... Wang J, Hartling JA, Flanagan JM (November 1997). "The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent ... "Entrez Gene: CLPP ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)". Katayama-Fujimura Y, ...
Clp protease family
Endopeptidase Clp ATP-dependent Clp protease proteolytic subunit Maurizi MR, Clark WP, Katayama Y, Rudikoff S, Pumphrey J, ... ClpP endopeptidase family, clan SK). ClpP is an ATP-dependent protease that cleaves a number of proteins, such as casein and ... April 2013). "Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered ... Bowers B, Gottesman S (July 1990). "Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp ...
Endopeptidase Clp
... (EC 3.4.21.92, endopeptidase Ti, caseinolytic protease, protease Ti, ATP-dependent Clp protease, ClpP, Clp ... Endopeptidase CLP protease family ATP-dependent Clp protease proteolytic subunit Gottesman S, Clark WP, Maurizi MR (May 1990 ... Maurizi MR, Thompson MW, Singh SK, Kim SH (1994). "Endopeptidase Clp: ATP-dependent Clp protease from Escherichia coli". ... "The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate". The ...
ClpX
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial is an enzyme that in humans is encoded by the CLPX gene ... Endopeptidase Clp). The knowledge of human ClpX protein are majorly based on the investigations on E. coli protein. The monomer ... ClpP2 ClpX is an ATP-dependent chaperone that can recognize protein substrates by binding to protein degradation tags. These ... ATP binding can stabilize the association between ClpX and ClpP ring structures. In Mycobacteria, the ClpXP protease is ...
Endopeptidase La
ATP-dependent serine proteinase, lon proteinase, protease La, proteinase La, ATP-dependent lon proteinase, ATP-dependent ... A heat-shock gene which encodes the ATP-dependent protease La". The Journal of Biological Chemistry. 263 (24): 11718-28. PMID ... Desautels M, Goldberg AL (October 1982). "Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of ... Larimore FS, Waxman L, Goldberg AL (April 1982). "Studies of the ATP-dependent proteolytic enzyme, protease La, from ...
CLPP
... may refer to: CLP protease family, a family of proteolytic enzymes Endopeptidase Clp, an enzyme complex ATP-dependent Clp ...
CLP
... may stand for: CLP protease family, a family of proteolytic enzymes Endopeptidase Clp, an enzyme complex ATP-dependent Clp ...
List of MeSH codes (D08)
... atp-dependent proteases MeSH D08.811.277.656.149.200 - endopeptidase clp MeSH D08.811.277.656.149.500 - protease la MeSH ... cyclin-dependent kinase 5 MeSH D08.811.913.696.620.682.700.200.067.900 - cyclin-dependent kinase 9 MeSH D08.811.913.696.620.682 ... cyclin-dependent kinase 4 MeSH D08.811.913.696.620.682.700.200.515 - cyclin-dependent kinase 6 MeSH D08.811.913.696.620.682. ... cyclin-dependent kinase 5 MeSH D08.811.913.696.620.682.700.646.500.750 - cyclin-dependent kinase 2 MeSH D08.811.913.696.620.682 ...
Proteasome
Later, the ATP-dependent proteolytic complex that was responsible for ubiquitin-dependent protein degradation was discovered ... Wilk S, Orlowski M (November 1980). "Cation-sensitive neutral endopeptidase: isolation and specificity of the bovine pituitary ... After a protein has been ubiquitinated, it is recognized by the 19S regulatory particle in an ATP-dependent binding step. The ... Ciehanover A, Hod Y, Hershko A (April 1978). "A heat-stable polypeptide component of an ATP-dependent proteolytic system from ...
RAD21
... is cleaved by several proteases including Separase and Calcium-dependent cysteine endopeptidase Calpain-1 during mitosis ... Opening of this interface is regulated by ATP-binding by the SMC subunits. This causes the ATPase head domains to dimerise and ... October 2015). "Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis". The Journal of Experimental ... Kosugi S, Hasebe M, Tomita M, Yanagawa H (June 2009). "Systematic identification of cell cycle-dependent yeast ...
Chromosome 14
... encoding enzyme ATP-dependent RNA helicase DDX24 DEGS2: encoding protein Delta(4)-desaturase, sphingolipid 2 DLGAP5: Disks ... encoding enzyme Probable O-sialoglycoprotein endopeptidase PAPOLA: encoding enzyme Poly(A) polymerase alpha PCNX: encoding ...
Glucagon-like peptide-1
Alongside glucose-dependent insulinotropic peptide (GIP), GLP-1 is an incretin; thus, it has the ability to decrease blood ... Neutral endopeptidase 24.11 (NEP 24.11) is a membrane-bound zinc metallopeptidase widely expressed in several tissues, but ... During the process, influx of glucose ensures sufficient ATP to sustain the stimulatory effect. Additionally, GLP-1 ensures the ... The most noteworthy effect of GLP-1 is its ability to promote insulin secretion in a glucose-dependent manner. As GLP-1 binds ...
Chromosome 2
ATP-binding cassette, subfamily A, members 5 and 8 ASXL2: Additional sex combs like 2, transcriptional regulator ATRAID: ... U12-dependent splicing) RPL37A: encoding protein 60S ribosomal protein L37a SATB2: Homeobox 2 SCARNA5: Small Cajal body- ... Prolyl endopeptidase-like PXDN: Peroxidasin homolog QPCT: Glutaminyl-peptide cyclotransferase RETSAT: All-trans-retinol 13,14- ... ATP-binding cassette, subfamily A (ABC1), member 12 ACTR1B: encoding protein Beta-centractin AGXT: alanine-glyoxylate ...
Protease
Only two ATP-dependent proteases are found in archaea: the membrane associated LonB protease and a soluble 20S proteosome ... endopeptidases, such as trypsin, chymotrypsin, pepsin, papain, elastase). Catalysis is achieved by one of two mechanisms: ... Zelisko A, Jackowski G (October 2004). "Senescence-dependent degradation of Lhcb3 is mediated by a thylakoid membrane-bound ...
SbtB protein
SbtB not only takes part in the binding process of ATP and ADP, but is also the first ever known protein to bind the nucleotide ... It acts as a post-translational regulator (inhibitor) of the SbtA protein (one of the three sodium-dependant bicarbonate (Na+/ ... "AmiGO 2: Term Details for "serine-type endopeptidase activity" (GO:0004252)". Amigo. Gene Ontology Consortium. Retrieved 2018- ... ScSbtB has shown to bind ATP, ADP and cAMP with dissociation constants (Kd) of 46, 19, and 11 μM respectively. The ring opened ...
Prostasomes
Brody I, Ronquist G, Gottfries A, Stegmayr B (1981). "Abnormal deficiency of both Mg2+ and Ca2+-dependent adenosine ... Ronquist G (1988). "Zinc ion stimulation of ATP cleavage by prostasomes from human seminal plasma". Urologia Internationalis. ... neutral endopeptidase, CD10); angiotensin converting enzyme (ACE, CD143); tissue factor TF (CD142, thromboplastin); decay ... ATP)". Biochimica et Biophysica Acta (BBA) - General Subjects. 1830 (10): 4604-10. doi:10.1016/j.bbagen.2013.05.019. PMID ...
SNARE (protein)
Then, the hexameric ATPase (of the AAA type) called NSF catalyzes the ATP-dependent unfolding of the SNARE proteins and ... The light chain has zinc-dependent endopeptidase or more specifically matrix metalloproteinase (MMP) activity through which ... The ATP hydrolysis-coupled dissociation of SNARE complexes is an energy investment that can be compared to "cocking the gun" so ... The light chain of BoNT acts as a metalloprotease on SNARE proteins that is dependent on Zn(II) ions, cleaving them and ...
List of EC numbers (EC 3)
Ste24 endopeptidase EC 3.4.24.85: S2P endopeptidase EC 3.4.24.86: ADAM 17 endopeptidase EC 3.4.24.87: ADAMTS13 endopeptidase EC ... ADP-dependent short-chain-acyl-CoA hydrolase EC 3.1.2.19: ADP-dependent medium-chain-acyl-CoA hydrolase EC 3.1.2.20: acyl-CoA ... phosphoribosyl-ATP diphosphatase EC 3.6.1.32: Now EC 3.6.4.1, myosin ATPase EC 3.6.1.33: Now EC 3.6.4.2, dynein ATPase EC 3.6. ... Ste24 endopeptidase EC 3.4.24.85: S2P endopeptidase EC 3.4.24.86: ADAM 17 endopeptidase EC 3.4.24.87: ADAMTS13 endopeptidase EC ...
PSMB10
... are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process ... "Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like ...
CLPP gene: MedlinePlus Genetics
ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog. *endopeptidase Clp. *PRLTS3. *putative ATP-dependent ... Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease. Am J Hum ... ClpXP, an ATP-powered unfolding and protein-degradation machine. Biochim Biophys Acta. 2012 Jan;1823(1):15-28. doi: 10.1016/j. ... ClpP: a distinctive family of cylindrical energy-dependent serine proteases. FEBS Lett. 2007 Jul 31;581(19):3749-57. doi: ...
TCDB » SEARCH
DeCS
ATP-dependent endopeptidases Descripteur en anglais: ATP-Dependent Endopeptidases Descripteur en espagnol: Endopeptidasas ATP- ... ATP-dependent endopeptidases - Concept préféré Concept UI. M0095032. Terme préféré. ATP-dependent endopeptidases ... endopeptidasas dependientes del ATP. Note dapplication:. Endoproteasas que contienen dominios centrales proteolíticos y ... Endoprotéases ATP-dépendantes. Code(s) darborescence:. D08.811.277.040.013.500.032.099. D08.811.277.040.025.024.032.099. ...
Physical and functional association of RNA polymerase II and the proteasome<...
Proteasome Endopeptidase Complex Medicine & Life Sciences 89% * ATP dependent 26S protease Medicine & Life Sciences 80% ... in a transcription-dependent fashion. The appearance of the proteasome on these inducible genes correlates with both the ... in a transcription-dependent fashion. The appearance of the proteasome on these inducible genes correlates with both the ... in a transcription-dependent fashion. The appearance of the proteasome on these inducible genes correlates with both the ...
Time-resolved multi-omics analysis reveals the role of nutrient stress-induced resource reallocation for TAG accumulation in...
In addition, ATP from substrate phosphorylation was presumed to be a critical factor regulation of the global resource ... Proteases involved in the UPS, such as proteasome complexes and endopeptidase complexes, are also ATP-dependent and are ... In addition, levels of other ATP-dependent enzymes, such as HK, PFK and ATP citrate lyase (ACL) that play important roles in ... Here, we found that UBA1 is ATP dependent [70]; therefore, when ATP decreased to a threshold level, it inhibits UBA1 activity ...
Seed Viewer - Organism
EC 3.4.21.- Serine endopeptidase (1). Proteolysis in bacteria, ATP-dependent (12). ... ATP-dependent@^ATP-dependent Clp protease ATP-binding subunit [email protected]^fig,[email protected]~Protein [email protected]^Protein ... ATP-dependent@^ATP-dependent Clp protease ATP-binding subunit [email protected]^fig,[email protected]~Protein [email protected]^Protein ... ATP-dependent@^ATP-dependent hsl protease ATP-binding subunit [email protected]^fig,[email protected]~Protein [email protected]^Protein ...
DeCS 2010 - Novos termos
Endopeptidases Dependentes de ATP. ATP-Dependent Endopeptidases. Endopeptidasas ATP-Dependientes. Histona Desacetilase 1. ... Cyclin-Dependent Kinase 3. Quinasa 3 Dependiente de la Ciclina. Quinase 8 Dependente de Ciclina. Cyclin-Dependent Kinase 8. ... Cyclin-Dependent Kinase 3. Quinasa 3 Dependiente de la Ciclina. Quinase 8 Dependente de Ciclina. Cyclin-Dependent Kinase 8. ... Cyclin-Dependent Kinase 8. Quinasa 8 Dependiente de la Ciclina. Subunidade 1 do Complexo Mediador. Mediator Complex Subunit 1. ...
Network Portal - Gene PA1801
Physiology - Division B - Fingerprint - University of Texas Southwestern Medical Center
"probe","sequence id","alias",...
NWMN 1897 - AureoWiki
Pesquisa | Portal Regional da BVS
Protein Concepts Dictionary
ENDOPEPTIDASE 5.0 ATP DEPENDENT PROTEASE 4.7 CYTOPLASM 3.5 SER PROTEASE 3.5 PROTEOLYSIS 3.5 HETEROCOMPLEX 3.5 ENZYME CATALYSIS ... ATP DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1.7 CYTOSOL 1.7 CHAPERON 1.7 ALPHA BETA HALF SANDWICH 1.5 PEPTIDE SUBSTRATE 1.2 ... ATP BINDING 7.4 PEPTIDASE 6.7 CLP PROTEASE 6.4 DEGRADATION 6.4 ANTIMICROBIAL 6.4 AGONIST 5.9 ZYMOGEN 5.9 WHOLE PROTEOME 5.9 ... ENDOPEPTIDASE CLP 13.9 CASEINOLYTIC PROTEASE 11.4 VIRULENCE FACTOR 11.4 REGULATION 11.4 CLP PROTEASE FAMILY 11.1 STRESS ...
Code System Concept
SMART: Pfam domain Peptidase M41
ATP-dependent peptidase activity (GO:0004176), metalloendopeptidase activity (GO:0004222), ATP binding (GO:0005524). ... This group of metallopeptidases belong to MEROPS peptidase family M41 (FtsH endopeptidase family, clan MA(E)). The predicted ... FtsH is an integral membrane protein, which seems to act as an ATP-dependent zinc metallopeptidase that binds one zinc ion. ... which is a putative ATP-dependent protease required for assembly of the mitochondrial respiratory chain and ATPase complexes. ...
Bio2Vec
Pre GI: CDS description
endopeptidase la (ATP-dependent protease la 1). NC_011969:4140000:4164738. NC_011969:4140000. Bacillus cereus Q1 chromosome, ... S16 family endopeptidase La. NC_016843:1:15748. NC_016843:1. Treponema pallidum subsp. pertenue str. Gauthier chromosome,. ... S16 family endopeptidase La. NC_021508:12543:15743. NC_021508:12543. Treponema pallidum subsp. pallidum SS14, complete genome. ... S16 family endopeptidase La. NC_016848:12548:15748. NC_016848:12548. Treponema pallidum subsp. pertenue str. CDC2 chromosome, ...
Albert Einstein College of Medicine - Grants
- Albert Einstein College of Medicine
Pesquisa | Portal Regional da BVS
In the present study, first, we found that GA could inhibit the proliferation of BmNPV in a dose-dependent manner and delay the ... Predominant downregulation of GOs represents serine-type endopeptidases, structural constituents of ribosomes and integral ... membrane components and differential upregulation of ATP binding, nucleus and translation, while up-regulation of nucleic acid ... Ingestion of a defensin from Capsicum annuum (CanDef-20) induced a dose-dependent reduction in larval and pupal mass, delayed ...
DeCS 2010 - Novos termos
Endopeptidases Dependentes de ATP. ATP-Dependent Endopeptidases. Endopeptidasas ATP-Dependientes. Histona Desacetilase 1. ... Cyclin-Dependent Kinase 3. Quinasa 3 Dependiente de la Ciclina. Quinase 8 Dependente de Ciclina. Cyclin-Dependent Kinase 8. ... Cyclin-Dependent Kinase 3. Quinasa 3 Dependiente de la Ciclina. Quinase 8 Dependente de Ciclina. Cyclin-Dependent Kinase 8. ... Cyclin-Dependent Kinase 8. Quinasa 8 Dependiente de la Ciclina. Subunidade 1 do Complexo Mediador. Mediator Complex Subunit 1. ...
DeCS 2010 - New terms
ATP-Dependent Endopeptidases. Endopeptidases Dependentes de ATP. Endopeptidasas ATP-Dependientes. Aspartic Acid Proteases. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 3. Quinase 3 Dependente de Ciclina. Quinasa 3 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ...
DeCS 2010 - Novos termos
Endopeptidases Dependentes de ATP. ATP-Dependent Endopeptidases. Endopeptidasas ATP-Dependientes. Histona Desacetilase 1. ... Cyclin-Dependent Kinase 3. Quinasa 3 Dependiente de la Ciclina. Quinase 8 Dependente de Ciclina. Cyclin-Dependent Kinase 8. ... Cyclin-Dependent Kinase 3. Quinasa 3 Dependiente de la Ciclina. Quinase 8 Dependente de Ciclina. Cyclin-Dependent Kinase 8. ... Cyclin-Dependent Kinase 8. Quinasa 8 Dependiente de la Ciclina. Subunidade 1 do Complexo Mediador. Mediator Complex Subunit 1. ...
DeCS 2010 - New terms
ATP-Dependent Endopeptidases. Endopeptidases Dependentes de ATP. Endopeptidasas ATP-Dependientes. Aspartic Acid Proteases. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 3. Quinase 3 Dependente de Ciclina. Quinasa 3 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ...
DeCS 2010 - New terms
ATP-Dependent Endopeptidases. Endopeptidases Dependentes de ATP. Endopeptidasas ATP-Dependientes. Aspartic Acid Proteases. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 3. Quinase 3 Dependente de Ciclina. Quinasa 3 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ...
DeCS 2010 - New terms
ATP-Dependent Endopeptidases. Endopeptidases Dependentes de ATP. Endopeptidasas ATP-Dependientes. Aspartic Acid Proteases. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 3. Quinase 3 Dependente de Ciclina. Quinasa 3 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ...
DeCS 2010 - New terms
ATP-Dependent Endopeptidases. Endopeptidases Dependentes de ATP. Endopeptidasas ATP-Dependientes. Aspartic Acid Proteases. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 3. Quinase 3 Dependente de Ciclina. Quinasa 3 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ...
DeCS 2010 - New terms
ATP-Dependent Endopeptidases. Endopeptidases Dependentes de ATP. Endopeptidasas ATP-Dependientes. Aspartic Acid Proteases. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 3. Quinase 3 Dependente de Ciclina. Quinasa 3 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ...
DeCS 2010 - New terms
ATP-Dependent Endopeptidases. Endopeptidases Dependentes de ATP. Endopeptidasas ATP-Dependientes. Aspartic Acid Proteases. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 3. Quinase 3 Dependente de Ciclina. Quinasa 3 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ...
DeCS 2010 - New terms
ATP-Dependent Endopeptidases. Endopeptidases Dependentes de ATP. Endopeptidasas ATP-Dependientes. Aspartic Acid Proteases. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 3. Quinase 3 Dependente de Ciclina. Quinasa 3 Dependiente de la Ciclina. ... Cyclin-Dependent Kinase 8. Quinase 8 Dependente de Ciclina. Quinasa 8 Dependiente de la Ciclina. ...
DeCS 2010 - Novos termos
Endopeptidases Dependentes de ATP. ATP-Dependent Endopeptidases. Endopeptidasas ATP-Dependientes. Histona Desacetilase 1. ... Cyclin-Dependent Kinase 3. Quinasa 3 Dependiente de la Ciclina. Quinase 8 Dependente de Ciclina. Cyclin-Dependent Kinase 8. ... Cyclin-Dependent Kinase 3. Quinasa 3 Dependiente de la Ciclina. Quinase 8 Dependente de Ciclina. Cyclin-Dependent Kinase 8. ... Cyclin-Dependent Kinase 8. Quinasa 8 Dependiente de la Ciclina. Subunidade 1 do Complexo Mediador. Mediator Complex Subunit 1. ...
SerinePutativeClpPInterproscanFtsHPhosphorylationExopeptidasePhosphateMembraneProtonReceptorTranscriptionHighly dependentDisplaysEssentialActivationProteaseMitochondrialSERINE ENDOPEPTIDASESComplexHydrolysisUbiquitinReduced ATP levelsProlylAdenosine TriphosphateNUCLEOTIDE BINDINGProteasesProteolyticEnzymesSynthasePathwayProteinsCellTiter-GloPost-TranslationalTransporterActivityReplicationInhibitorsRespirationRegulatorAssayProtein-degradationRenalNADPEscherichiaBiologicallyBindingDescriptorUptakeGeneCellularATPasesZincProcessAMPKPromotesPolymeraseEnzyme
Serine3
- ClpP: a distinctive family of cylindrical energy-dependent serine proteases. (medlineplus.gov)
- NS3 plays a central role in the flavivirus life cycle: the NS3 N-terminal serine protease together with its essential cofactor NS2B is involved in the processing of the polyprotein, whereas the NS3 C-terminal NTPase/helicase is responsible for ATP-dependent RNA strand separation during replication. (ox.ac.uk)
- Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. (paperbase.net)
Putative1
- This family includes the cell division protein FtsH, and the yeast mitochondrial respiratory chain complexes assembly protein, which is a putative ATP-dependent protease required for assembly of the mitochondrial respiratory chain and ATPase complexes. (embl.de)
ClpP1
- Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease. (medlineplus.gov)
Interproscan1
- phosphoenolpyruvate-dependent sugar phosphotransferase system [Interproscan]. (ntu.edu.sg)
FtsH2
- This group of metallopeptidases belong to MEROPS peptidase family M41 (FtsH endopeptidase family, clan MA(E)). The predicted active site residues for members of this family and thermolysin, the type example for clan MA, occur in the motif HEXXH. (embl.de)
- FtsH is an integral membrane protein, which seems to act as an ATP-dependent zinc metallopeptidase that binds one zinc ion. (embl.de)
Phosphorylation2
- In addition, ATP from substrate phosphorylation was presumed to be a critical factor regulation of the global resource allocation and fatty acids' synthesis rate. (biomedcentral.com)
- Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65. (paperbase.net)
Exopeptidase1
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17350041&query_hl=4&itool=pubmed_DocSum] Kiss AL, Hornung B, Rádi K, Gengeliczki Z, Sztáray B, Juhász T, Szeltner Z, Harmat V, Polgár L. "The acylaminoacyl peptidase from Aeropyrum pernix K1 thought to be an exopeptidase displays endopeptidase activity. (kenyon.edu)
Phosphate1
- Phosphate bonds of adenosine triphosphate (ATP) carry the energy required for all cellular functions. (medscape.com)
Membrane1
- Launch The purinergic P2X receptors (P2RXs) made up of seven associates in vertebrates, termed P2RX1-7, certainly are a category of ligand-gated membrane ion stations that open up in response towards the binding of extracellular ATP [1]. (exposed-skin-care.net)
Proton2
- La fonction primaire de ce nano-moteur est le transport actif (ATP-d pendant) de proton. (unis-neuro.com)
- Le couplage entre l hydrolyse de l ATP et le transport de proton par la V-ATPase joue un r le crucial dans l acidification des v sicules synaptiques et ainsi dans leur charge en neurotransmetteurs. (unis-neuro.com)
Receptor1
- ATP-gated P2X7 receptor (P2RX7) channel is normally an essential component for purinergic signaling and plays essential roles in the innate immune system response in mammals. (exposed-skin-care.net)
Transcription1
- We now find yet another intersection of these pathways by showing that the 26S proteasome associates with regions of the GAL1, GAL10, and HSP82 genes, including the 3′ ends, in a transcription-dependent fashion. (elsevier.com)
Highly dependent1
- Symptoms of hypophosphatemia are nonspecific and highly dependent on cause, duration, and severity. (medscape.com)
Displays1
- Obtainable literature has noted that seabream P2RX7 displays different agonist (ATP/BzATP)-evoked pharmacological replies from mammalian and zebrafish P2RX7s [19], recommending species distinctions of P2RX7 in agonist/antagonist actions may can be found in teleost. (exposed-skin-care.net)
Essential1
- A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens. (paperbase.net)
Activation1
- Furthermore, P2RX7 PF-03084014 needs at least a 100-flip higher ATP focus for activation than is necessary for various other P2XRs, and removal of divalent cations can boost its agonist strength [4]. (exposed-skin-care.net)
Protease3
- Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease. (medlineplus.gov)
- An ATP-dependent protease found in prokaryotes, CHLOROPLASTS , and MITOCHONDRIA . (bvsalud.org)
- The stress-induced ClpXP protease is a member of the ATP-dependent proteases, which are known to be responsible for more than 90% of all proteolysis in Escherichia coli. (unboundmedicine.com)
Mitochondrial3
- Peroxynitrite can inhibit the mitochondrial respiratory string, which implicates the participation of ATP reduction and eventually prospects to irreversible mobile harm20, 21. (acmbcb.org)
- It has been reported that genetically identical eukaryotic cells show significant cell-to-cell variability of cellular mitochondrial mass caused by inhomogeneous distribution of mitochondria during cell department [9] which presumably leads to differing [ATP]i between cells from the same inhabitants. (cancerhugs.com)
- Expression of nuclear and mitochondrial genes encoding ATP synthase is synchronized by disassembly of a multisynthetase complex. (cnrs.fr)
SERINE ENDOPEPTIDASES2
- The Deg/HtrA family of ATP-independent serine endopeptidases is present in nearly all organisms from bacteria to human and vascular plants. (biomedcentral.com)
- They are ATP-independent serine endopeptidases found in all domains of life, including Bacteria, Archaea and Eukarya. (biomedcentral.com)
Complex3
- EPR spectroscopy of surface mutants of the complex containing a covalently bound spin label at distinct positions demonstrates NADH-dependent conformational changes in both arms of the complex. (labome.org)
- Steuber J. The C-terminally truncated NuoL subunit (ND5 homologue) of the Na+-dependent complex I from Escherichia coli transports Na+. (labome.org)
- This particle recognizes the N-terminal signal-sequence of the nascent polypeptide chain and then transports it to the ER membrane where the complex, consisting of SRP, polypeptide chain and ribosome, is recognized by the ER membrane bound signal recognition particle receptor (SR). After this recognition the polypeptide chain is imported into the ER lumen via the SEC channel in an ATP dependent process. (tu-muenchen.de)
Hydrolysis3
- The interaction of this signal with 26S proteasomes is modulated by ATP hydrolysis. (nih.gov)
- In each hydrolysis step, ATP is required. (comprehensivephysiology.com)
- ATP hydrolysis activity and polymerization state of ribulose-1,5-bisphosphate carboxylase oxygenase activase. (usda.gov)
Ubiquitin3
- Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (nih.gov)
- The results suggest that Sem1, possibly hDSS1, is a novel subunit of the 26 S proteasome and plays a role in ubiquitin-dependent proteolysis. (labome.org)
- Hence the Ubiquitin-Activating Enzyme (UbA1 also called E1) initiates the ubiquitination cascade by catalyzing the ATP-dependent adenylation from the Ub C-terminus (stage I). The high-energy anhydride connection thus formed is normally attacked with the E1 energetic site cysteine (C632 in individual UbA1) developing a thioester connection between E1 and Ub (stage II). (schwitzbiotech.com)
Reduced ATP levels1
- Prolonged mitotic arrest results in mitophagy-dependent loss of mitochondria, accompanied by reduced ATP levels and the activation of AMPK. (sebbm.es)
Prolyl3
- prolyl endopeptidase [Sorangium cellulos. (virginia.edu)
- prolyl endopeptidase [Cupriavidus taiwan. (virginia.edu)
- Under normoxia, HIF1a is usually hydroxylated on many proline residues, within an oxygen-dependent response [38], by a family group of prolyl hydroxylases (PHDs). (welbourneprimary.com)
Adenosine Triphosphate1
- Phosphate bonds of adenosine triphosphate (ATP) carry the energy required for all cellular functions. (medscape.com)
NUCLEOTIDE BINDING1
- In order to gain a deeper understanding of the developing lung, we applied an activity-based chemoproteomics approach for the functional characterization of the xenometabolizing cytochrome P450 enzymes, active ATP and nucleotide binding enzymes, and serine hydrolases using a suite of activity-based probes (ABPs). (nih.gov)
Proteases1
- ClpP: a distinctive family of cylindrical energy-dependent serine proteases. (medlineplus.gov)
Proteolytic2
Enzymes1
- using our ATP-ABP, we characterized a wide range of ATPases and other active nucleotide- and nucleic acid-binding enzymes involved in multiple facets of cellular metabolism throughout development. (nih.gov)
Synthase2
- The sensor cyclic GMP-AMP synthase (cGAS) detects cytosolic DNA and synthesizes the second messenger 2′3′-cGAMP from ATP and GTP. (elifesciences.org)
- ATP synthase peripheral stalk subuni. (gsea-msigdb.org)
Pathway3
- As the ATP risk signal triggered IL-33 discharge from basal airway epithelial cells (10), the results supplied a pathway from APEC extension to elevated basal cell appearance and discharge of IL-33 to cause a sort 2 immune system response. (stemcellethics.net)
- Silencing of Velo led to constitutive expression of the IMD pathway dependent antimicrobial peptides (AMPs), and Escherichia coli stimulation further enhanced the AMP expression. (cnrs.fr)
- Epistatic analysis indicated that Velo knock-down mediated AMP upregulation is dependent on the canonical members of the IMD pathway. (cnrs.fr)
Proteins5
- 产品介绍】CLPP belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. (fortunebio-tech.com)
- DG may also activate Ca 2+ ‐ and phospholipid‐dependent protein kinase, leading to phosphorylation of membrane proteins. (comprehensivephysiology.com)
- A diverse family of proteins involved in ATP-dependent RNA or DNA. (systemsbiology.net)
- Mutations in the ATP-binding sites of individual Rpt proteins all reduced the affinity of 19S complexes for the ER, suggesting that the 19S base in the ATP-bound conformation docks at the Sec61 channel. (labome.org)
- Calcium-dependent proteins kinase 1 (CDPK1) represents a appealing medication focus on, as CDPK1 is probable descended in the place lineage of and therefore is normally absent from mammalian hosts (18,C21). (multicongress.org)
CellTiter-Glo1
- C) CellTiter-Glo (ATP-based) assay 48 hours +/- doxycyline as a measure of cell viability. (bioscinet.org)
Post-Translational1
- The post-translational import to the ER lumen is done by chaperons which guide the polypeptide chain to the SEC channel which is then imported in an ATP dependent process. (tu-muenchen.de)
Transporter2
- ABC transporter ATP-binding protein [Sin. (virginia.edu)
- sugar uptake ABC transporter ATP-binding. (virginia.edu)
Activity4
- CDPK1 activity is vital for microneme secretion, web host cell invasion, and egress of (18, 22, 23) and will end up being selectively targeted with a course of ATP-competitive substances, collectively called bumped kinase inhibitors (BKIs). (multicongress.org)
- Furthermore, the reduced amount of reporter activity of promoter due to DACH1 overexpression happened within a dosage-dependent way (Fig. (researchreport-digital.com)
- their energy production is derived largely from glycolysis DSP-0565 rather than oxidative phosphorylation, and low activity of the learn metabolic regulator AMP-dependent kinase (AMPK) reduces p53 levels and activates anabolic factors, such as acetyl CoA. (biogeology.org)
- Variation in metabolic activity results in fluctuation of [ATP]i. (cancerhugs.com)
Replication1
- evaluation shows that WRNIP1 binds to forked DNA that mimics stalled replication forks within an ATP-dependent way (Yoshimura et?al. (yearofevolution.org)
Inhibitors1
- Many TKIs are little molecules specifically concentrating on the MET kinase site, PR22 such as for example ATP-competitive inhibitors [28]. (welbourneprimary.com)
Respiration2
- Basal (D), optimum (E) ATP-dependent/oligomycin inhibitable (F) respiration and reserve capability (G) were computed in the OCR traces matching to each substrate as depicted in A-C. Beliefs will be the mean SE of observations created from 15C30 wells from two split tests. (sc-26196.com)
- Oxidative respiration is replaced by glycolysis owing to AMPK-dependent phosphorylation of PFKFB3 and increased production of this protein as a consequence of mitotic-specific translational activation of its mRNA. (sebbm.es)
Regulator2
- Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. (systemsbiology.net)
- They offer the proteasome framework, interact with regulatory things and elements, such as the 19S ATP-dependent regulator, and control the gain access to of protein into the catalytic holding chamber [19]. (cancerhugs.com)
Assay1
- An oxygen-dependent killing assay using hydrogen peroxide and paraquat (a superoxide anion generator) and a serum killing assay using murine serum demonstrated that all of the serovar Typhimurium Delta clpP and Delta clpX mutants were as resistant to these killing mechanisms as the wild-type strain. (unboundmedicine.com)
Protein-degradation1
- ClpXP, an ATP-powered unfolding and protein-degradation machine. (medlineplus.gov)
Renal2
- Zaiad Abassi, "Pulmonary and renal neutral endopeptidase EC3.4.24.11 in rats with experimental heart failure. (nih.gov)
- Renal kallikrein secretion is definitely accelerated by potassium and ATP-sensitive potassium (KATP) route blockers, such as for example PNU-37883A. (cell-signaling-pathways.com)
NADP1
- Examples include ATP, NAD, NADP and S-adenosylmethionine, as well as a number of vitamins, such as riboflavin (vitamin B1) and thiamine (vitamin B2). (guidetopharmacology.org)
Escherichia1
- Cell sorting enriches Escherichia coli mutants that rely on peptidoglycan endopeptidases to suppress highly aberrant morphologies. (uams.edu)
Biologically1
- We recently showed that peanut protein in household dust is usually positively correlated with household peanut consumption.16 In addition, we showed Iressa ic50 that peanut protein in dust activates basophils from children with peanut allergy in a dose-dependent manner and is thus biologically active.16 We hypothesized that peanut sensitization can occur through presentation of environmental peanut antigen through an impaired skin barrier to underlying antigen-presenting cells. (columbiagypsy.net)
Binding2
- RGD-dependent binding of TP508 to integrin alphavbeta3 mediates cell adhesion and induction of nitric oxide. (vanderbilt.edu)
- ATP binding cassette subfamily C mem. (gsea-msigdb.org)
Descriptor1
- Endopeptidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Uptake3
- ATP-dependent Ca-uptake by rat vas deferens smooth muscle microsomes: properties of oxalate stimulated and oxalate-independent Ca-uptake. (mcmaster.ca)
- In "white" cells light-dependent 0 2-uptake is also observed. (mpg.de)
- The FH null cells showed a substantial metabolic reorganization of their intracellular metabolic fluxes to fulfill their high ATP demand, as observed by a high rate of glucose uptake, increased glucose turnover via glycolysis, high production of glucose-derived lactate, and low entry of glucose carbon into the Krebs cycle. (biogeology.org)
Gene1
- Next we compared gene expression profiles of Foxp3+ Treg subsets (+) of different maturity (24lo, 24int, 24hi) and could identify a set of genes that were specifically up or downregulated in Foxp3+ Tregs, but not in Foxp3- conventional T cells, in a maturation-dependent manner. (gsea-msigdb.org)
Cellular2
- Cellular fitness is often measured by quantifying ATP levels (e.g. (cancerhugs.com)
- Due to its simple accessibility e.g. by an ATP-dependent luciferase-luciferin reaction [ATP]i has been a long-serving indicator of cellular viability. (cancerhugs.com)
ATPases1
- Rubin D, Glickman M, Larsen C, Dhruvakumar S, Finley D. Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. (labome.org)
Zinc1
- ATP-dependent zinc metalloprotease FTSH 7, chloroplastic OS=Oryza sativa subsp. (ntu.edu.sg)
Process1
- Vesicle budding from the tER is an ATP-dependent process. (nih.gov)
AMPK1
- En esas condiciones, una ruta molecular en la que intervienen AMPK y PFKFB3 induce la glucólisis y las células paradas en mitosis muestran unos requerimientos aumentados a la glucosa, una adición que puede tener implicaciones en terapia del cáncer. (sebbm.es)
Promotes1
- In summary, ATP promotes protein breakdown by the proteasome through multiple mechanisms, as reflected by the diverse phenotypes of the rpt mutants. (labome.org)
Polymerase2
- RNA-dependent RNA polymerase, SARS-CoV-like / Nonstructural protein 15, middle domain, alpha/betacoronavirus / Nonstructural protein 14, betacoronavirus / Coronavirus (CoV) Nsp15 N-terminal oligomerization domain profile. (pdbj.org)
- Coronavirus Nsp12 RNA-dependent RNA polymerase (RdRp) domain profile. (pdbj.org)
Enzyme1
- The enzyme degraded casein, but of the 11 synthetic endopeptidase substrates tested, only benzyloxycarbonyl-leucine-leucine-glutamic acid-beta-napthylamide was hydrolyzed at measurable rates. (usda.gov)