ATP Citrate (pro-S)-Lyase

Citric Acid

Citrates

Citrate (si)-Synthase

Acetate-CoA Ligase

Coenzyme A

Lyases

Malate Dehydrogenase

Acetyl Coenzyme A

Acetyl-CoA Carboxylase

Liver

Fatty Acid Synthases

Oxo-Acid-Lyases

Kinetics

Polysaccharide-Lyases

Rats, Inbred Strains

Adenylosuccinate Lyase

citrate (pro-3S)-lyase) ligase

List of MeSH codes (D08)

List of EC numbers (EC 4)

List of enzymes

List of EC numbers (EC 2)

Succinic acid

List of EC numbers (EC 6)

List of EC numbers (EC 3)

Amino acid synthesis

Morpheein

Enzyme5

• An enzyme that, in the presence of ATP and COENZYME A , catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP , and ORTHOPHOSPHATE . (nih.gov)
• The activities of hepatic enzymes--glucose-6-phosphate dehydrogenase, malic enzyme and citrate cleavage enzyme--were stimulated at least twofold by restriction and refeeding when compared to ad libitum feeding. (tamu.edu)
• An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. (lookformedical.com)
• It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC 4.1.3.7. (lookformedical.com)
• HCA inhibits ATP citrate lyase an enzyme involved in fatty acid synthesis. (nih.gov)

Bempedoic acid3

• Bempedoic acid (ETC-1002) is a small molecule intended to lower LDL-C in hypercholesterolemic patients, and has been previously shown to modulate both ATP-citrate lyase (ACL) and AMP-activated protein kinase (AMPK) activity in rodents. (nih.gov)
• The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects. (bvsalud.org)
• SIGNIFICANCE STATEMENT This study characterizes the disposition and metabolism of bempedoic acid , an inhibitor of ATP citrate lyase for hypercholesterolemia . (bvsalud.org)

Cleavage1

• Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible formation of succinyl-CoA from succinate and CoA with the concomitant cleavage of ATP to ADP (EC 6.2.1.5) or GTP to GDP (EC 6.2.1.4) and orthophosphate. (lookformedical.com)

ACLY4

• ATP-citrate lyase (ACLY) catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, coupled with the hydrolysis of ATP. (rcsb.org)
• The pro-S carboxylate is free to react, providing insight into the stereospecificity of ACLY. (rcsb.org)
• Comparisons of the nucleotide-binding site of SCSs with the similar structure in ACLY indicates that this is the ATP-binding site of ACLY. (rcsb.org)
• ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and acetylation reactions. (nih.gov)

Inhibition1

• Furthermore, pharmacological inhibition of mTORC1, using rapamycin or its analogs (rapalogs), can mimic the pro-longevity effects of DR. Conversely, nutritional amino acid overload has been tightly linked to aging and diseases, such as cancer, type 2 diabetes and obesity. (biomed.news)

Citrato1

• Enzima que, en presencia de ATP y COENZIMA A, cataliza la escisión del citrato para dar lugar a acetil CoA, oxalacetato, ADP y ORTOFOSFATO. (bvsalud.org)

Metabolic2

• The growing field of immunometabolism has taught us how metabolic cellular reactions and processes not only provide a means to generate ATP and biosynthetic precursors, but are also a way of controlling immunity and inflammation. (nature.com)
• 1 Pro-inflammatory signals will induce a metabolic switch in both myeloid and lymphoid cells, resulting in upregulation of aerobic glycolysis in a manner similar to the Warburg effect described in cancer cells. (nature.com)

Activity2

• stranded DNA and rRNA to poly(A) with a wide range like a DNA glycosylase/apurinic (ap) lyase, an addi- of activity and specificity (Barbieri et al. (nih.gov)
• lase/ap lyase activity. (nih.gov)

Presence1

• The crystals were grown in the presence of tartrate or the substrate, citrate, and the structure revealed the citrate-binding site. (rcsb.org)

Role1

• 10. ATP Citrate Lyase and LncRNA NONMMUT010685 Play Crucial Role in Nonalcoholic Fatty Liver Disease Based on Analysis of Microarray Data. (nih.gov)

Effects1

• 13. Histone deacetylase inhibitor suberoylanilide hydroxamic acid suppresses the pro-oncogenic effects induced by hepatitis B virus pre-S2 mutant oncoprotein and represents a potential chemopreventive agent in high-risk chronic HBV patients. (nih.gov)

Catalyzes the cleavage of citrate2

• This effect is specially attributed to (-)-hydroxycitric acid (HCA) inhibiting the enzyme ATP-dependent citrate lyase, which catalyzes the cleavage of citrate to oxaloacetate and acetyl-CoA. (nih.gov)
• An enzyme that, in the presence of ATP and COENZYME A , catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP , and ORTHOPHOSPHATE . (nih.gov)

Colorectal cancer1

• 15. Bax is necessary for PGC1α pro-apoptotic effect in colorectal cancer cells. (nih.gov)