An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.
A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
Enzyme that catalyzes the first step of the tricarboxylic acid cycle (CITRIC ACID CYCLE). It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC 4.1.3.7.
An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.
A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.
An enzyme that catalyzes the conversion of (S)-malate and NAD+ to oxaloacetate and NADH. EC 1.1.1.37.
Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives.
Enzymes that catalyze the cleavage of a carbon-carbon bond of a 3-hydroxy acid. (Dorland, 28th ed) EC 4.1.3.
The rate dynamics in chemical or physical systems.
A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in polysaccharides leading to an unsaturated product and the elimination of an alcohol. EC 4.2.2.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
An enzyme that catalyzes reversibly the hydrolysis of acetyl-CoA to yield CoA and acetate. The enzyme is involved in the oxidation of fatty acids. EC 3.1.2.1.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
A genus of fleas in the family Pulicidae which includes the species that serves as the primary vector of BUBONIC PLAGUE, Xenopsylla cheopis.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
Substances used to destroy or inhibit the action of rats, mice, or other rodents.
Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.
The reduction or regulation of the population of noxious, destructive, or dangerous rodents through chemical, biological, or other means.
A plant genus of the family POACEAE that contains the Poa p Ia allergen and allergen C KBGP.
Glycosidic antibiotic from Streptomyces griseus used as a fluorescent stain of DNA and as an antineoplastic agent.
Cysts found in the jaws and arising from epithelium involved in tooth formation. They include follicular cysts (e.g., primordial cyst, dentigerous cyst, multilocular cyst), lateral periodontal cysts, and radicular cysts. They may become keratinized (odontogenic keratocysts). Follicular cysts may give rise to ameloblastomas and, in rare cases, undergo malignant transformation.
A region extending from the PONS & MEDULLA OBLONGATA through the MESENCEPHALON, characterized by a diversity of neurons of various sizes and shapes, arranged in different aggregations and enmeshed in a complicated fiber network.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Organized activities related to the storage, location, search, and retrieval of information.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Tumors or cancer of the human BREAST.
One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
An estrogen responsive cell line derived from a patient with metastatic human breast ADENOCARCINOMA (at the Michigan Cancer Foundation.)
A cell line derived from cultured tumor cells.
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
... atp citrate (pro-s)-lyase MeSH D08.811.913.050.350 - carnitine acyltransferases MeSH D08.811.913.050.350.170 - carnitine O- ... chondroitin lyases MeSH D08.811.520.241.700.350.500.500 - chondroitin abc lyase MeSH D08.811.520.241.700.512 - heparin lyase ... tyrosine phenol-lyase MeSH D08.811.520.232.300 - amidine-lyases MeSH D08.811.520.232.300.200 - adenylosuccinate lyase MeSH ... ammonia-lyases MeSH D08.811.520.232.400.200 - aspartate ammonia-lyase MeSH D08.811.520.232.400.350 - ethanolamine ammonia-lyase ...
... citrate (pro-3S)-lyase(acetyl form) The 3 substrates of this enzyme are ATP, acetate, and citrate (pro-3S)-lyase(thiol form), ... pro-3S)-lyase ligase (EC 6.2.1.22) is an enzyme that catalyzes the chemical reaction ATP + acetate + citrate (pro-3S)-lyase( ... pro-3S)-lyase(thiol-form) ligase (AMP-forming). Other names in common use include citrate lyase ligase, citrate lyase ... HS-citrate lyase ligase, and acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming). This enzyme participates in two- ...
... citrate (pro-3S)-lyase) ligase EC 6.2.1.23: Dicarboxylate-CoA ligase EC 6.2.1.24: Phytanate-CoA ligase EC 6.2.1.25: Benzoate- ... ATP synthase (EC 3.6.3.14) Kynureninase EC 3.7.1.3 EC 3.8.1.3 Haloacetate dehalogenase EC 3.9.1.1: Phosphoamidase EC 3.9.1.2: ... EC 4.3.1 Phenylalanine ammonia-lyase (EC 4.3.1.24) Category:EC 4.4.1 Cystathionine gamma-lyase Cystathionine beta-lyase ... Citrate-CoA ligase EC 6.2.1.19: Long-chain-fatty-acid-luciferin-component ligase EC 6.2.1.20: Long-chain-fatty-acid-(acyl- ...
... citrate (pro-3S)-lyase) ligase EC 6.2.1.23: dicarboxylate-CoA ligase EC 6.2.1.24: phytanate-CoA ligase EC 6.2.1.25: benzoate- ... ATP) EC 6.5.1.2: DNA ligase (NAD+) EC 6.5.1.3: RNA ligase (ATP) EC 6.5.1.4: RNA-3'-phosphate cyclase EC 6.6.1.1: magnesium ... citrate-CoA ligase EC 6.2.1.19: long-chain-fatty-acid-luciferin-component ligase EC 6.2.1.20: long-chain-fatty-acid-(acyl- ... ATP-hydrolysing)) ligase EC 6.3.4.11: biotin-(methylcrotonoyl-CoA-carboxylase) ligase EC 6.3.4.12: glutamate-methylamine ligase ...
... hydroxymethylglutaryl-CoA lyase EC 4.1.3.5: now EC 2.3.3.10 EC 4.1.3.6: citrate (pro-3S)-lyase EC 4.1.3.7: now EC 2.3.3.1 EC ... ATP-dependent NAD(P)H-hydrate dehydratase EC 4.2.1.94: scytalone dehydratase EC 4.2.1.95: kievitone hydratase EC 4.2.1.96: 4a- ... pectin lyase EC 4.2.2.11: poly(a-L-guluronate) lyase EC 4.2.2.12: xanthan lyase EC 4.2.2.13: exo-(1-4)-α-D-glucan lyase EC 4.2. ... pectate lyase EC 4.2.2.3: poly(b-D-mannuronate) lyase EC 4.2.2.4: chondroitin ABC lyase EC 4.2.2.5: chondroitin AC lyase EC 4.2 ...
Succinate is generated from succinyl-CoA by the enzyme succinyl-CoA synthetase in a GTP/ATP-producing step: Succinyl-CoA + NDP ... The pathway avoids the decarboxylation steps of the TCA cycle via the enzyme isocitrate lyase which cleaves isocitrate into ... including the pro-inflammatory cytokine interleukin-1β. Other inflammatory cytokines produced by activated macrophages such as ... which moves both dicarboxylate and citrate into the bloodstream. Extracellular succinate can act as a signaling molecule with ...
... citrate-(pro-3S)-lyase) S-acetyltransferase EC 2.3.1.50: serine C-palmitoyltransferase EC 2.3.1.51: 1-acylglycerol-3-phosphate ... ATP citrate synthase EC 2.3.3.9: malate synthase EC 2.3.3.10: hydroxymethylglutaryl-CoA synthase EC 2.3.3.11: 2- ... citrate (Si)-synthase EC 2.3.3.2: decylcitrate synthase EC 2.3.3.3: citrate (Re)-synthase EC 2.3.3.4: decylhomocitrate synthase ... protein-histidine pros-kinase EC 2.7.13.2: protein-histidine tele-kinase EC 2.7.13.3: histidine kinase EC 2.7.99.1: ...
In E. coli citrate synthase, the enzyme involved in the condensation reaction initiating the Citric Acid Cycle is strongly ... Aspartic acid is produced by the addition of ammonia to fumarate using a lyase. Annigan, Jan. "How Many Amino Acids Does the ... Phosphoribosyl-ATP converts to phosphoribosyl-AMP (PRAMP). His4 then catalyzes the formation of phosphoribosylformiminoAICAR- ... Met-Thr-Arg-Val-Gln-Phe-Lys-His-His-His-His-His-His-His-Pro-Asp This leader sequence is important for the regulation of ...
Functional Consequences of ATP- and dATP-Induced Oligomerization of the Large Subunit†". Biochemistry. 41 (2): 462-74. doi: ... Tong, E. K.; Duckworth, Harry W. (1975). "Quaternary structure of citrate synthase from Escherichia coli K 12". Biochemistry. ... of a Mutant Bacillus subtilis Adenylosuccinate Lyase Equivalent to a Mutant Enzyme Found in Human Adenylosuccinate Lyase ... Pro mutant human phenylalanine hydroxylase". European Journal of Biochemistry. 268 (4): 997-1005. doi:10.1046/j.1432-1327.2001. ...
... citrate lyase deacetylase EC 3.1.2.17: (S)-methylmalonyl-CoA hydrolase EC 3.1.2.18: ADP-dependent short-chain-acyl-CoA ... Xaa-Pro dipeptidyl-peptidase EC 3.4.14.12: Xaa-Xaa-Pro tripeptidyl-peptidase EC 3.4.15.1: peptidyl-dipeptidase A EC 3.4.15.2: ... Now included with EC 3.5.2.6 β-lactamase EC 3.5.2.9: 5-oxoprolinase (ATP-hydrolysing) EC 3.5.2.10: creatininase EC 3.5.2.11: L- ... Now EC 3.6.4.2, dynein ATPase EC 3.6.1.34: Transferred entry: H+-transporting ATP synthase. Now EC 3.6.3.14, H+-transporting ...
EC 6.2.1.22: [[[Citrate (pro-3S)-lyase] ligase]]. *EC 6.2.1.23: Dicarboxylate--CoA ligase ... ATP synthase (EC 3.6.3.14). Category:EC 3.7 (act on carbon-carbon bonds)Edit. *Kynureninase EC 3.7.1.3 ... Category:Lyases (EC 4) (Lyase)Edit. Category:EC 4.1 (carbon-carbon lyases)Edit. *Category:EC 4.1.1 *Ornithine decarboxylase (EC ... 4 Category:Lyases (EC 4) (Lyase) *4.1 Category:EC 4.1 (carbon-carbon lyases) ...
GS catalyzes the ATP-dependent condensation of glutamate with ammonia to yield glutamine.[4] The hydrolysis of ATP drives[8] ... doi:10.1002/pro.5560041114. PMC 2143006. PMID 8563633.. *^ a b c d Liaw SH, Pan C, Eisenberg D (Jun 1993). "Feedback inhibition ... citrate. glycine→serine→. *Serine hydroxymethyltransferase. *Serine dehydratase. *glycine→creatine: Guanidinoacetate N- ... EC4 Lyases (list). *EC5 Isomerases (list). *EC6 Ligases (list). *EC7 Translocases (list) ...
... especially ATP formation, to the regulation of cellular function. Dysregulation of succinate synthesis, and therefore ATP ... The pathway avoids the decarboxylation steps of the TCA cycle via the enzyme isocitrate lyase which cleaves isocitrate into ... including the pro-inflammatory cytokine interleukin-1β.[39] Other inflammatory cytokines produced by activated macrophages such ... which moves both dicarboxylate and citrate into the bloodstream.[30] ...
This happens at intracellular sites where ATP is used in the cell, with CK acting as an in situ ATP regenerator. ... citrate. glycine→serine→. *Serine hydroxymethyltransferase. *Serine dehydratase. *glycine→creatine: Guanidinoacetate N- ... EC4 Lyases (list). *EC5 Isomerases (list). *EC6 Ligases (list). *EC7 Translocases (list) ... The bound cytosolic CK accepts the PCr shuttled through the cell and uses ADP to regenerate ATP, which can then be used as ...
ATP Citrate (pro-S)-Lyase/physiology*. *Amino Acid Sequence. *Cell Division/physiology* ... ATP citrate lyase is an important component of cell growth and transformation.. Bauer DE1, Hatzivassiliou G, Zhao F, Andreadis ... the ability of cells to produce cytosolic acetyl CoA from mitochondria-derived citrate through the action of ATP citrate lyase ...
ACLY, ATP-citrate lyase; ETC, electron transport chain; GLS, glutaminase; α-KG, α-ketoglutarate; LDH, lactate dehydrogenase; l ... In addition to supporting these needs, metabolic pathways govern the function of pro-repair immune cells, including regulatory ... Nutrient depletion following tissue damage also affects pro-repair cell function through metabolic signaling pathways, ... initiating signaling pathways that likewise control pro-repair cell function. ...
ATP Citrate (pro-S)-Lyase Grant support * DRG-1714-02/RG/CSR NIH HHS/United States ... ATP citrate lyase inhibition can suppress tumor cell growth Cancer Cell. 2005 Oct;8(4):311-21. doi: 10.1016/j.ccr.2005.09.008. ... A key enzyme linking glucose metabolism to lipid synthesis is ATP citrate lyase (ACL), which catalyzes the conversion of ... citrate to cytosolic acetyl-CoA. ACL inhibition by RNAi or the chemical inhibitor SB-204990 limits in vitro proliferation and ...
ATP Citrate (pro-S)-Lyase / antagonists & inhibitors * ATP Citrate (pro-S)-Lyase / metabolism ... ATP-citrate lyase and glucose-6-phosphate dehydrogenase decreased as the dietary level of sesamin increased in Exp. 1 and in ...
ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central ... ATP-citrate synthase (EC:2.3.3.8). Alternative name(s):. ATP-citrate (pro-S-)-lyase ... IPR014608. ATP-citrate_synthase. IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR032263. Citrate-bd. IPR016142. Citrate_synth-like ... IPR014608. ATP-citrate_synthase. IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR032263. Citrate-bd. IPR016142. Citrate_synth-like ...
adenosine triphosphate citrate lyase;. citrate cleavage enzyme;. citrate-ATP lyase;. citric cleavage enzyme;. ATP citrate (pro- ... ATP citrate synthase;. ATP-citric lyase;. ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO--,acetyl-CoA] (ATP-dephosphorylating); ... Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase. ... ATP citrate (pro-S)-lyase. K15230 ATP-citrate lyase alpha-subunit. K15231 ATP-citrate lyase beta-subunit. ...
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo ... ATP-citrate synthase, EC 2.3.3.8 (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) ... ATP-citrate synthase, EC 2.3.3.8 (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) ... ATP-citrate synthase, EC 2.3.3.8 (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) ...
ATP citrate (pro-S)-lyase [EC:2.3.3.8] K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23] K00665 FASN; fatty acid ... 24159 Acly; ATP-citrate synthase isoform 1 54237 Cdk1; cyclin-dependent kinase 1 50671 Fasn; fatty acid synthase 292804 Gpi; ...
... adenosine triphosphate citrate lyase; citrate cleavage enzyme; citrate-ATP lyase; citric cleavage enzyme; ATP citrate (pro-S)- ... citrate + CoA. Other name(s): ATP-citric lyase; ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-→acetyl-CoA] (ATP- ... Accepted name: ATP citrate synthase. Reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + ... Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase. Eur. J. Biochem. 125 (1982) 645- ...
ATP Citrate (pro-S)-Lyase Medicine & Life Sciences * Aspergillus Chemical Compounds * Organic acids Chemical Compounds ... Gene deletion of cytosolic ATP: citrate lyase leads to altered organic acid production in Aspergillus niger. In: Journal of ... Meijer SL, Nielsen ML, Olsson L, Nielsen J. Gene deletion of cytosolic ATP: citrate lyase leads to altered organic acid ... Meijer, S. L., Nielsen, M. L., Olsson, L., & Nielsen, J. (2009). Gene deletion of cytosolic ATP: citrate lyase leads to altered ...
ATP-citrate lyase Antibody Phospho (pT447/pS451), Rabbit Monoclonal Antibody validated in WB, IF (AJ1067c), Abgent ... ATP-citrate synthase, ATP-citrate (pro-S-)-lyase, ACL, Citrate cleavage enzyme, ACLY. ... pro-S) lyase was used as immunogen. The antibody only detects ATP-citrate (pro-S) lyase phosphorylated on Threonine 447 and ... ATP citrate lyase (ACLY), also known as ATP citrate synthase, is the primary enzyme responsible for the synthesis of cytosolic ...
Identification of the active site residues in ATP-citrate lyases carboxy-terminal portion. ... doi: 10.1002/pro.3708. Epub 2019 Aug 27.. PMID:. 31411782. Similar articles ... ATP-specificity of succinyl-CoA synthetase from Blastocystis hominis.. Huang J, Nguyen VH, Hamblin KA, Maytum R, van der Giezen ...
ATP-citric lyase activity. *ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)-,acetyl-CoA) (ATP- dephosphorylating) activity ... ATP citrate (pro-S)-lyase activity. *acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP- ... ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating). *acetyl-CoA:oxaloacetate ... Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.. ...
AKT phosphorylates Ser-454 on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis ... Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum. 3240. ... AKT phosphorylates Ser-454 on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis ... Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea: ...
... has been linked to acetyl-CoA levels through the activity of the cytosolic acetyl-CoA-generating enzyme ATP-citrate lyase (ACLY ... derived macrophages has been linked to acetyl-CoA levels through the activity of the cytosolic acetyl-CoA-generating enzyme ATP ... citrate lyase (ACLY). Here, we studied how ACLY regulated IL-4-stimulated gene expression in human primary macrophages. ... in response to pro-inflammatory stimuli (36), which remains to be validated in primary cells. ...
AKT phosphorylates Ser-454 on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis ... The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival ...
AKT phosphorylates Ser-454 on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis ... Phosphorylation of BAD stimulates its pro-apoptotic activity.[3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17 ... Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol ... Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol ...
AKT phosphorylates Ser-454 on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis ... Phosphorylation of BAD stimulates its pro- apoptotic activity. Phosphorylates KAT6A at Thr-369 and this phosphorylation ... The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival ...
ATP citrate synthase activity. 6.07828121800931. bayes_pls_golite062009. *citrate (pro-3S)-lyase activity ... ATP citrate lyase, isoform A [Drosophila melanogaster] [NCBI NR] *gi,24653990,ref,NP_725514.1, ATP citrate lyase, isoform B [ ... ATP citrate lyase, isoform A [Drosophila melanogaster] [NCBI NR] *gi,21645324,gb,AAM70940.1, ATP citrate lyase, isoform B [ ... citrate metabolic process [ISS] Molecular Function:. ATP binding [IEA] ATP citrate synthase activity [ISS][NAS] succinate-CoA ...
21535 choline ABC transporter ATP-binding pro K02000 410 100 ( -) 29 0.321 84 -, 1 ppsl:BJP27_14770 choline ABC transporter ATP ... pgm:PGRAT_02120 citrate lyase subunit beta 361 100 ( -) 29 0.375 48 ,-, 1 pkt:AT984_15345 hypothetical protein 196 100 ( -) 29 ... gba:J421_0163 ATP-binding region ATPase domain protein 461 104 ( -) 30 0.343 70 -, 1 mrs:Murru_1650 hypothetical protein 142 ... cput:CONPUDRAFT_103047 calcium calmodulin-dependent pro K06268 175 659 ( 389) 156 0.602 161 ,-, 7 wse:WALSEDRAFT_60317 calcium- ...
... citrate (pro-3S)-lyase(acetyl form) The 3 substrates of this enzyme are ATP, acetate, and citrate (pro-3S)-lyase(thiol form), ... pro-3S)-lyase ligase (EC 6.2.1.22) is an enzyme that catalyzes the chemical reaction ATP + acetate + citrate (pro-3S)-lyase( ... pro-3S)-lyase(thiol-form) ligase (AMP-forming). Other names in common use include citrate lyase ligase, citrate lyase ... HS-citrate lyase ligase, and acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming). This enzyme participates in two- ...
Browse our ATP Citrate Lyase Lysate catalog backed by our Guarantee+. ... ATP Citrate Lyase Lysates available through Novus Biologicals. ... ATP citrate synthase lysate, ATP-citrate (pro-S-)-lyase lysate ... ATP Citrate Lyase Lysates. We offer ATP Citrate Lyase Lysates for use in common research applications: Western Blot. Each ATP ... Our ATP Citrate Lyase Lysates can be used in a variety of model species. Use the list below to choose the ATP Citrate Lyase ...
Genes encoding citrate synthase, isocitrate dehydrogenase, ATP citrate (pro-S)-lyase, aconitate hydratase, and isocitrate ... Significantly rhythmical expression patterns of genes involved in steroid biosynthesis, fatty acid metabolism, the citrate ... as influenced by ATP, predict their role in protein maintenance and stress tolerance throughout diapause. During diapause, the ...
Sul, HS, Wise, LS, Brown, ML & Rubin, CS 1984, Cloning of cDNA sequences for murine malic enzyme and ATP citrate lyase. ... T1 - Cloning of cDNA sequences for murine malic enzyme and ATP citrate lyase. Evidence for the pretranslational regulation of ... Cloning of cDNA sequences for murine malic enzyme and ATP citrate lyase. Evidence for the pretranslational regulation of ... Cloning of cDNA sequences for murine malic enzyme and ATP citrate lyase. Evidence for the pretranslational regulation of ...
... atp citrate (pro-s)-lyase MeSH D08.811.913.050.350 - carnitine acyltransferases MeSH D08.811.913.050.350.170 - carnitine O- ... chondroitin lyases MeSH D08.811.520.241.700.350.500.500 - chondroitin abc lyase MeSH D08.811.520.241.700.512 - heparin lyase ... tyrosine phenol-lyase MeSH D08.811.520.232.300 - amidine-lyases MeSH D08.811.520.232.300.200 - adenylosuccinate lyase MeSH ... ammonia-lyases MeSH D08.811.520.232.400.200 - aspartate ammonia-lyase MeSH D08.811.520.232.400.350 - ethanolamine ammonia-lyase ...
Citrate cleavage enzyme, ATP-citrate synthase, ATP-citrate (pro-S-)-lyase, ATP citrate synthase, CLATP, ATP citrate lyase, ... Anti-ATP Citrate Lyase Rabbit Polyclonal Antibody. Anti-ATP Citrate Lyase Rabbit Polyclonal Antibody. Supplier: Novus ... The ATP Citrate Lyase Antibody from Novus Biologicals is a rabbit polyclonal antibody to ATP Citrate Lyase. This antibody ... The ATP Citrate Lyase Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, ...
Pros: This once-a-day pill-the first in a new class of non-statin drugs (called ATP Citrate Lyase inhibitors)-is an additional ... Pros: EPA (eicosapentaenoic acid) is a type of omega 3 fatty acid found in fish and fish oil. Icosapent ethyl (Vascepa) is a ... Pros: Whether you opt for the DASH diet-short for Dietary Approaches to Stop Hypertension-or a Mediterranean-style diet, youll ... Pros: Soluble fiber-the type found in oats, beans, apples, and other plants-binds to cholesterol in the intestine and whisks it ...
ACL, ACLY, ATP citrate (pro S ) lyase, ATP citrate lyase, ATP citrate synthase, ATPCL, Citrate cleavage enzyme, CLATP ... ACLY(ATP-citrate synthase) is also named as ACL. It is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA ... Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate ...
ATP Citrate Lyase (ACLY): A Promising Target for Cancer Prevention and Treatment. Current Drug Targets ... Rationally Designed Anti-mitotic Agents with Pro-Apoptotic Activity. Current Pharmaceutical Design ...
ATP-citrate lyase, one of the key enzymes of this cycle, was partially purified from C. limicola strain M1 and the N-terminal ... ATP-citrate lyase, one of the key enzymes of this cycle, was partially purified from C. limicola strain M1 and the N-terminal ... ATP-citrate lyase, one of the key enzymes of this cycle, was partially purified from C. limicola strain M1 and the N-terminal ... ATP-citrate lyase, one of the key enzymes of this cycle, was partially purified from C. limicola strain M1 and the N-terminal ...
  • Recently, IL-4-induced polarization of murine bone marrow-derived macrophages (BMDMs) has been linked to acetyl-CoA levels through the activity of the cytosolic acetyl-CoA-generating enzyme ATP-citrate lyase (ACLY). (frontiersin.org)
  • Although several reactions provide acetyl-CoA for histone acetylation, ATP-citrate lyase (ACLY) is considered to predominantly contribute to nuclear pool of acetyl-CoA ( 8 ). (frontiersin.org)
  • AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. (drugbank.ca)
  • We constructed genetic scores composed of independently inherited variants in the genes encoding ATP citrate lyase ( ACLY ) and HMGCR to create instruments that mimic the effect of ATP citrate lyase inhibitors and HMGCR inhibitors (statins), respectively. (cdc.gov)
  • Measurements of those cells taken at 15 weeks of age showed that social isolation stimulated significant increases in the expression of three genes-Hk2 (hexokinase), Acly ( ATP citrate lyase ) and Acaca (acetyl-CoA carboxykase). (thefreedictionary.com)
  • We investigated ATP citrate lyase (ACLY) because it cleaves citrate into oxaloacetate and acetyl CoA. (elsevier.com)
  • ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. (ssrn.com)
  • Thus, PIP2/PIP3 binding and Src tyrosine kinases-mediated stimulation of ACLY links oncogenic pathways to Acetyl-CoA-dependent pro-growth and survival metabolic pathways in cancer cells. (ssrn.com)
  • Kenneth Verstraete in the Unit for Structural Biology at the VIB-UGent Center for Inflammation Research has unraveled the three-dimensional structure and molecular mechanism of ATP citrate lyase (ACLY). (ehealthweek2010.org)
  • The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase). (genome.jp)
  • In enzymology, a citrate (pro-3S)-lyase ligase (EC 6.2.1.22) is an enzyme that catalyzes the chemical reaction ATP + acetate + citrate (pro-3S)-lyase(thiol form) ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + citrate (pro-3S)-lyase(acetyl form) The 3 substrates of this enzyme are ATP, acetate, and citrate (pro-3S)-lyase(thiol form), whereas its 3 products are AMP, diphosphate, and citrate (pro-3S)-lyase(acetyl form). (wikipedia.org)
  • The systematic name of this enzyme class is acetate:citrate (pro-3S)-lyase(thiol-form) ligase (AMP-forming). (wikipedia.org)
  • Other names in common use include citrate lyase ligase, citrate lyase synthetase, acetate: SH-acyl-carrier-protein enzyme ligase (AMP), acetate:HS-citrate lyase ligase, and acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming). (wikipedia.org)
  • ATP-citrate lyase, one of the key enzymes of this cycle, was partially purified from C. limicola strain M1 and the N-terminal sequence of a 65-kDa protein was found to show similarity toward eukaryotic ATP-citrate lyase. (elsevier.com)
  • ATP-binding cassette sub-family A member 1 (ATP-binding cassettetransporter 1) (ATP-binding cassette 1) (ABC-1) (Cholesterol effluxregulatory protein). (nctu.edu.tw)
  • 9. The method of claim 4 wherein the polynucleotide comprises a promoter that is expressible in the colorectal cancer cell and that is operably linked to a sequence encoding a polypeptide selected from the group consisting of a pro-apoptotic protein, a tumor suppressor protein, a protein that inhibits cell cycle progression, and a protein involved in the delivery of toxic secondary bile acids into the cytoplasm of colorectal cancer cells. (freepatentsonline.com)
  • The latter compound in turn reacts with with a citrate lyase acyl-carrier protein through a apo-citrate lyase phosphoribosyl-dephospho-CoA transferase resulting in the release of a pyrophosphate and a hydrogen ion and a holo citrate lyase acyl-carrier protein.This protein complex can either react with a hydrogen ion and a acetate resulting in the release of a water and an acetyl-holo citrate lyase acyl-carrier protein. (smpdb.ca)
  • The holo acyl-carrier protein creacts with an ATP and an acetate through a citrate lyase synthase resulting in the release of an AMP, a pyrophosphate and an acetyl-holo citrate lyase acyl-ccarrier protein. (smpdb.ca)
  • The holo citrate lyase acyl-carrier protein can also interact with an S-acetyl phosphopantethiene resulting in the release of a 4-phosphopantethiene and an acetyl-holo citrate lyase acyl-carrier protein. (smpdb.ca)
  • Because of HCA and other influential mixes it serves to prompt fats by making moderate the creation of protein known ATP-citrate lyase, this catalyst is in charge of making fats and additional carbs. (globalfreead.com)
  • Purified recombinant human ATP-citrate synthase (C-terminal) protein fragments expressed in E.coli. (insightbio.com)
  • Studying the 'pro-death' machinery that forces damaged, diseased or unwanted cells to die, the research team revealed a protein called VDAC2 was critical for the function of a key pro-death protein called Bax. (ehealthweek2010.org)
  • The net conversion of glucose to lipid is dependent on the ability of cells to produce cytosolic acetyl CoA from mitochondria-derived citrate through the action of ATP citrate lyase (ACL). (nih.gov)
  • A key enzyme linking glucose metabolism to lipid synthesis is ATP citrate lyase (ACL), which catalyzes the conversion of citrate to cytosolic acetyl-CoA. (nih.gov)
  • ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. (uniprot.org)
  • The gene target for complete gene deletion was cytosolic ATP: citrate lyase (acl), which had previously been identified by using genome-scale stoichiometric metabolic model simulations. (dtu.dk)
  • A gene on chromosome 17q21.2 that encodes ATP citrate lyase, the main enzyme responsible for synthesising cytosolic acetyl-CoA, which catalyses the formation of acetyl-CoA and oxaloacetate from citrate and CoA with hydrolysis of ATP to ADP and phosphate. (thefreedictionary.com)
  • The potassium salt of HCA is more out there where by it competes with citrate molecules for the enzymatic action of ATP citrate lyase. (alltdesign.com)
  • The ATP Citrate Lyase Antibody from Novus Biologicals is a rabbit polyclonal antibody to ATP Citrate Lyase. (vwr.com)
  • The ATP Citrate Lyase Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin. (vwr.com)
  • Immunofluorescence (IF) analysis of HeLa cells using ATP-citrate synthase Monoclonal antibody. (insightbio.com)
  • Western Blot (WB) analysis using ATP-citrate synthase Monoclonal antibody against K562, HeLa cell lysate. (insightbio.com)
  • Flow cytometric (FCM) analysis of HeLa cells stained with ATP-citrate synthase Monoclonal antibody (red), followed by FITC-conjugated goat anti- Mouse IgG. (insightbio.com)
  • The primary comparisons were insulin sensitivity by hyper-insulinemic-euglycemic clamp and skeletal muscle mitochondrial capacity for oxidative phosphorylation (OXPHOS) by measuring mitochondrial DNA copy number (mtDNA), OXPHOS gene transcripts, citrate synthase activity, and maximal mitochondrial ATP production rate (MAPR). (elsevier.com)
  • The effects of insulin on ATP-citrate lyase, its mRNA in cytosol, and the transcriptional activity in nuclei of diabetic rat liver were studied. (bvsalud.org)
  • It is suggested that the increase in the amount of ATP-citrate lyase by insulin is primarily due to the increase in the transcriptional activity of the gene in nuclei, which results in the subsequent increase in the amount of mRNA for the biosynthesis of ATP-citrate lyase in cytosol. (bvsalud.org)
  • However, activated immune or cancer cells can also export citrate to the cytosol, where it is converted back to acetyl-coenzyme A (acetyl-CoA) by ATP citrate lyase. (frontiersin.org)
  • Citric acid is eventually converted into fatty acid by the action of an enzyme called ATP citrate lyase , resulting in the accumulation of fat. (thefreedictionary.com)
  • Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. (string-db.org)
  • Citric acid (citrate) is a weak acid that is formed in the tricarboxylic acid cycle or that may be introduced with diet. (hmdb.ca)
  • The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. (hmdb.ca)
  • Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. (uniprot.org)
  • The enzyme catalyzed the cleavage of citrate in an ATP-, CoA- and Mg 2+ -dependent manner, where ATP and Mg 2+ could be replaced by dATP and Mn 2+ , respectively. (elsevier.com)
  • An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. (bvsalud.org)
  • We offer ATP Citrate Lyase Lysates for use in common research applications: Western Blot. (novusbio.com)
  • PMID 12957820 ) The secretory epithelial cells of the prostate gland of humans and other animals posses a unique citrate-related metabolic pathway regulated by testosterone and prolactin. (hmdb.ca)
  • Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. (leibniz-fli.de)
  • The activity and gene expression of enzymes involved in fatty acid synthesis including acetyl-CoA carboxylase, fatty acid synthase, ATP-citrate lyase and glucose-6-phosphate dehydrogenase decreased as the dietary level of sesamin increased in Exp. (nih.gov)
  • The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. (drugbank.ca)
  • ATP citrate lyase is an enzyme in the cholesterol-biosynthesis pathway upstream of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the target of statins. (cdc.gov)
  • ATP-citrate lyase (ACL), an enzyme catalyzing the first step in biosynthesis of fatty acids, is induced during the lipogenesis and cholesterologenesis. (bvsalud.org)
  • Inhibition of ATP Citrate Lyase (ACL) by bempedoic acid reduces cholesterol biosynthesis and lowers LDL-C by up-regulating the LDL receptor. (thefreedictionary.com)
  • With a targeted mechanism of action, bempedoic acid is a first-in-class, ATP Citrate Lyase (ACL) inhibitor that reduces cholesterol biosynthesis and lowers LDL-C by up-regulating the LDL receptor. (thefreedictionary.com)
  • In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. (acris-antibodies.com)
  • Schneider K, Dimroth P, Bott M: Biosynthesis of the prosthetic group of citrate lyase. (smpdb.ca)
  • Heterologous expression of these genes in Escherichia coli showed that both gene products were essential for ATP-citrate lyase activity. (elsevier.com)
  • Collectively, these observations demonstrate that HG promotes ACL expression and translocation into the nucleus, where ACL converts citrate to acetyl-CoA to provide the substrate for histone acetylation, leading to upregulation of fibrogenic genes. (elsevier.com)
  • testosterone and prolactin regulation of these metabolic genes (which are constitutively expressed in all mammalian cells) is specific for these citrate-producing cells. (hmdb.ca)
  • After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). (cusabio.com)
  • This may be explained by a greater urinary citrate excretion in infants compared with adults. (elsevier.com)
  • This higher urinary citrate excretion was not due to a difference in renal proximal tubular Na/citrate cotransporter activity, nor renal cortical citrate synthase or ATP citrate lyase activities in infants as compared with adults. (elsevier.com)
  • Manipulation of plasma [K + ] to adult levels did not affect the higher urinary citrate excretion in infant rats. (elsevier.com)
  • Urinary citrate excretion in infant rats is greater than in adults but does not parallel tissue [citrate]. (elsevier.com)
  • On the contrary urinary citrate excretion is a common tool in the differential diagnosis of kidney stones, renal tubular acidosis and it plays also a role in bone diseases. (hmdb.ca)
  • It has been suggested that glucose metabolites and insulin are the most important factors inducing ATP-citrate lyase (ACL) by a high carbohydrate diet. (bvsalud.org)
  • The goal of this study was to address the role of ATP-citrate lyase (ACL), an enzyme that converts citrate to acetyl-CoA, in high glucose (HG)-induced histone acetylation and profibrotic gene expression. (elsevier.com)
  • Phosphorylation results in a 6-fold increase in V(max) and the conversion of citrate dependence from sigmoidal to hyperbolic. (uniprot.org)
  • Schneider K, Dimroth P, Bott M: Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group. (smpdb.ca)
  • It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC 4.1.3.7. (rush.edu)
  • Citrate cleavage enzyme and fatty acid synthesis. (elsevier.com)
  • Some of the biological effects of GCE, such as the inhibition of endogenous cholesterol synthesis, the manipulation of the ATP citrate lyase enzyme, and a decrease in metabolic glucose consumption, are shared with statin drugs whose prolonged use has been associated with a significantly increased risk of diabetes. (greenmedinfo.com)
  • The product is an oral and once-daily ATP Citrate Lyase (ACL) inhibitor, which reduces cholesterol and fatty acid synthesis in the liver. (thefreedictionary.com)
  • This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway. (semanticscholar.org)
  • Reactive oxygen species abundant in oxidative environments cause damage to mitochondrial DNA, initiating signaling pathways that likewise control pro-repair cell function. (jci.org)
  • The key regulatory enzymes directly associated with citrate production in the prostate cells are mitochondrial aspartate aminotransferase, pyruvate dehydrogenase, and mitochondrial aconitase. (hmdb.ca)
  • It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. (acris-antibodies.com)
  • 2. Srere, P.A. and Lipmann, F. An enzymatic reaction between citrate, adenosine triphosphate and coenzyme A. (qmul.ac.uk)
  • This paper provides the first direct evidence that a bacterial ATP-citrate lyase is a heteromeric enzyme, distinct from mammalian enzymes. (elsevier.com)
  • The present study examines the renal excretion of citrate and renal cortical citrate metabolism in infant and adult rats. (elsevier.com)
  • Urine was collected after two days, and renal cortical citrate metabolism was assayed. (elsevier.com)
  • 2,16 The major "active" ingredient of GCE, hydroxycitric acid, inhibits the enzyme ATP citrate lyase. (greenmedinfo.com)
  • Hydroxycitric Acid (HCA) obstructs the enzyme adenosine triphosphate-citrate (pro-3S)-lyase, or ATP citrate (pro-3S)-lyasec from changing unused energy into fat. (best-weight-loss-tips.eu)
  • Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. (yeastrc.org)
  • This reaction requires an energy source such as ATP or NAD+. (leibniz-fli.de)
  • Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). (leibniz-fli.de)
  • Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine. (leibniz-fli.de)
  • Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase). (leibniz-fli.de)
  • Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. (leibniz-fli.de)
  • Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate. (leibniz-fli.de)
  • Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. (leibniz-fli.de)
  • Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate. (leibniz-fli.de)
  • Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. (leibniz-fli.de)
  • Whether the genetic inhibition of ATP citrate lyase is associated with deleterious outcomes and whether it has the same effect, per unit decrease in the low-density lipoprotein (LDL) cholesterol level, as the genetic inhibition of HMGCR is unclear. (cdc.gov)
  • Diminishing activity of NAD: ICDH through repression or significant decrease in intracellular AMP concentration via the activation of AMP deaminase would result in the accumulation of citrate which serves as the precursor for ATP citrate lyase (ACL). (thefreedictionary.com)
  • HCA additionally inhibits the power regarding the liver enzyme ATP Cytrate Lyase accountable for switching carbs into fat. (best-weight-loss-tips.eu)
  • Each ATP Citrate Lyase Lysate is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Three of them (Y682, Y252, Y227) can be also phosphorylated by Src and they are located in catalytic, citrate binding and ATP binding domains, respectively. (ssrn.com)
  • Identification of the active site residues in ATP-citrate lyase's carboxy-terminal portion. (nih.gov)
  • Synthetic peptide conjugated to KLH derived from within residues 200 - 300 of Human ATP citrate lyase. (abcam.co.jp)
  • ATP-specificity of succinyl-CoA synthetase from Blastocystis hominis. (nih.gov)