A superfamily of large integral ATP-binding cassette membrane proteins whose expression pattern is consistent with a role in lipid (cholesterol) efflux. It is implicated in TANGIER DISEASE characterized by accumulation of cholesteryl ester in various tissues.
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
An autosomal recessively inherited disorder caused by mutation of ATP-BINDING CASSETTE TRANSPORTERS involved in cellular cholesterol removal (reverse-cholesterol transport). It is characterized by near absence of ALPHA-LIPOPROTEINS (high-density lipoproteins) in blood. The massive tissue deposition of cholesterol esters results in HEPATOMEGALY; SPLENOMEGALY; RETINITIS PIGMENTOSA; large orange tonsils; and often sensory POLYNEUROPATHY. The disorder was first found among inhabitants of Tangier Island in the Chesapeake Bay, MD.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
The process of cleaving a chemical compound by the addition of a molecule of water.
A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.
Transport proteins that carry specific substances in the blood or across cell membranes.
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Established cell cultures that have the potential to propagate indefinitely.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
Proteins found in any species of fungus.
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Simultaneous resistance to several structurally and functionally distinct drugs.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Elements of limited time intervals, contributing to particular results or situations.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Proteins found in any species of bacterium.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Periplasmic proteins that scavenge or sense diverse nutrients. In the bacterial environment they usually couple to transporters or chemotaxis receptors on the inner bacterial membrane.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
The ability of fungi to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutations.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A family of sterols commonly found in plants and plant oils. Alpha-, beta-, and gamma-isomers have been characterized.
The rate dynamics in chemical or physical systems.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A family of scavenger receptors that are predominately localized to CAVEOLAE of the PLASMA MEMBRANE and bind HIGH DENSITY LIPOPROTEINS.
Proteins obtained from ESCHERICHIA COLI.
An oligopeptide produced by various bacteria which acts as a protease inhibitor.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Proteins involved in the transport of organic anions. They play an important role in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
An anthracenedione-derived antineoplastic agent.
An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
A class of organic compounds known as STEROLS or STEROIDS derived from plants.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.
The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).
Proteins prepared by recombinant DNA technology.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)
A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed)
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
A ubiquitously expressed glucose transporter that is important for constitutive, basal GLUCOSE transport. It is predominately expressed in ENDOTHELIAL CELLS and ERYTHROCYTES at the BLOOD-BRAIN BARRIER and is responsible for GLUCOSE entry into the BRAIN.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Membrane transporters that co-transport two or more dissimilar molecules in the same direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.
A family of proteins involved in the transport of monocarboxylic acids such as LACTIC ACID and PYRUVIC ACID across cellular membranes.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.
Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A cell line derived from cultured tumor cells.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.
Lipid-laden macrophages originating from monocytes or from smooth muscle cells.
Membrane proteins whose primary function is to facilitate the transport of negatively charged molecules (anions) across a biological membrane.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
A glutamate plasma membrane transporter protein found in ASTROCYTES and in the LIVER.
Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A neuronal and epithelial type glutamate plasma membrane transporter protein.
Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane.
5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial ATPase and also inhibits ATP-dependent reactions of oxidative phosphorylation.
A family of POTASSIUM and SODIUM-dependent acidic amino acid transporters that demonstrate a high affinity for GLUTAMIC ACID and ASPARTIC ACID. Several variants of this system are found in neuronal tissue.
Organic or inorganic compounds that contain the -N3 group.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)
An organic cation transporter found in kidney. It is localized to the basal lateral membrane and is likely to be involved in the renal secretion of organic cations.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
A glial type glutamate plasma membrane transporter protein found predominately in ASTROCYTES. It is also expressed in HEART and SKELETAL MUSCLE and in the PLACENTA.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of noradrenergic neurons. They remove NOREPINEPHRINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. It regulates signal amplitude and duration at noradrenergic synapses and is the target of ADRENERGIC UPTAKE INHIBITORS.
Salts and esters of CHOLIC ACID.

The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. (1/872)

The ABC1 transporter was identified as the defect in Tangier disease by a combined strategy of gene expression microarray analysis, genetic mapping, and biochemical studies. Patients with Tangier disease have a defect in cellular cholesterol removal, which results in near zero plasma levels of HDL and in massive tissue deposition of cholesteryl esters. Blocking the expression or activity of ABC1 reduces apolipoprotein-mediated lipid efflux from cultured cells, and increasing expression of ABC1 enhances it. ABC1 expression is induced by cholesterol loading and cAMP treatment and is reduced upon subsequent cholesterol removal by apolipoproteins. The protein is incorporated into the plasma membrane in proportion to its level of expression. Different mutations were detected in the ABC1 gene of 3 unrelated patients. Thus, ABC1 has the properties of a key protein in the cellular lipid removal pathway, as emphasized by the consequences of its defect in patients with Tangier disease.  (+info)

Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred. (2/872)

Tangier disease is characterized by low serum high density lipoproteins and a biochemical defect in the cellular efflux of lipids to high density lipoproteins. ABC1, a member of the ATP-binding cassette family, recently has been identified as the defective gene in Tangier disease. We report here the organization of the human ABC1 gene and the identification of a mutation in the ABC1 gene from the original Tangier disease kindred. The organization of the human ABC1 gene is similar to that of the mouse ABC1 gene and other related ABC genes. The ABC1 gene contains 49 exons that range in size from 33 to 249 bp and is over 70 kb in length. Sequence analysis of the ABC1 gene revealed that the proband for Tangier disease was homozygous for a deletion of nucleotides 3283 and 3284 (TC) in exon 22. The deletion results in a frameshift mutation and a premature stop codon starting at nucleotide 3375. The product is predicted to encode a nonfunctional protein of 1,084 aa, which is approximately half the size of the full-length ABC1 protein. The loss of a Mnl1 restriction site, which results from the deletion, was used to establish the genotype of the rest of the kindred. In summary, we report on the genomic organization of the human ABC1 gene and identify a frameshift mutation in the ABC1 gene of the index case of Tangier disease. These results will be useful in the future characterization of the structure and function of the ABC1 gene and the analysis of additional ABC1 mutations in patients with Tangier disease.  (+info)

An inventory of the human ABC proteins. (3/872)

Currently 30 human ABC proteins are represented by full sequences in various databases, and this paper provides a brief overview of these proteins. ABC proteins are composed of transmembrane domains (TMDs), and nucleotide binding domains (NBDs, or ATP-binding cassettes, ABSs). The arrangement of these domains, together with available membrane topology models of the family members, are presented. Based on their sequence similarity scores, the members of the human ABC protein family can be grouped into eight subfamilies. At present the MDR/TAP, the ALD, the MRP/CFTR, the ABC1, the White, the RNAseL inhibitor, the ANSA, and the GCN20 subfamilies are identified. Mutations of many human ABC proteins are known to be causative in inherited diseases, and a short description of the molecular pathology of these ABC gene-related genetic diseases is also provided.  (+info)

The ABCA subclass of mammalian transporters. (4/872)

We describe here a subclass of mammalian ABC transporters, the ABCA subfamily. This is a unique group that, in contrast to any other human ABC transporters, lacks a structural counterpart in yeast. The structural hallmark of the ABCA subfamily is the presence of a stretch of hydrophobic amino acids thought to span the membrane within the putative regulatory (R) domain. As for today, four ABCA transporters have been fully characterised but 11 ABCA-encoding genes have been identified. ABCA-specific motifs in the nucleotide binding folds can be detected when analysing the conserved sequences among the different members. These motifs may reveal functional constraints exclusive to this group of ABC transporters.  (+info)

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. (5/872)

Recently, the human ATP-binding cassette transporter-1 (ABC1) gene has been demonstrated to be mutated in patients with Tangier disease. To investigate the role of the ABC1 protein in an experimental in vivo model, we used gene targeting in DBA-1J embryonic stem cells to produce an ABC1-deficient mouse. Expression of the murine Abc1 gene was ablated by using a nonisogenic targeting construct that deletes six exons coding for the first nucleotide-binding fold. Lipid profiles from Abc1 knockout (-/-) mice revealed an approximately 70% reduction in cholesterol, markedly reduced plasma phospholipids, and an almost complete lack of high density lipoproteins (HDL) when compared with wild-type littermates (+/+). Fractionation of lipoproteins by FPLC demonstrated dramatic alterations in HDL cholesterol (HDL-C), including the near absence of apolipoprotein AI. Low density lipoprotein (LDL) cholesterol (LDL-C) and apolipoprotein B were also significantly reduced in +/- and -/- compared with their littermate controls. The inactivation of the Abc1 gene led to an increase in the absorption of cholesterol in mice fed a chow or a high-fat and -cholesterol diet. Histopathologic examination of Abc1-/- mice at ages 7, 12, and 18 mo demonstrated a striking accumulation of lipid-laden macrophages and type II pneumocytes in the lungs. Taken together, these findings demonstrate that Abc1-/- mice display pathophysiologic hallmarks similar to human Tangier disease and highlight the capacity of ABC1 transporters to participate in the regulation of dietary cholesterol absorption.  (+info)

Molecular basis for K(ATP) assembly: transmembrane interactions mediate association of a K+ channel with an ABC transporter. (6/872)

K(ATP) channels are large heteromultimeric complexes containing four subunits from the inwardly rectifying K+ channel family (Kir6.2) and four regulatory sulphonylurea receptor subunits from the ATP-binding cassette (ABC) transporter family (SUR1 and SUR2A/B). The molecular basis for interactions between these two unrelated protein families is poorly understood. Using novel trafficking-based interaction assays, coimmunoprecipitation, and current measurements, we show that the first transmembrane segment (M1) and the N terminus of Kir6.2 are involved in K(ATP) assembly and gating. Additionally, the transmembrane domains, but not the nucleotide-binding domains, of SUR1 are required for interaction with Kir6.2. The identification of specific transmembrane interactions involved in K(ATP) assembly may provide a clue as to how ABC proteins that transport hydrophobic substrates evolved to regulate other membrane proteins.  (+info)

ABC transporters in lipid transport. (7/872)

Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport. The evidence reviewed here shows that the MDR1 P-glycoprotein and the multidrug resistance (-associated) transporter 1 (MRP1) are able to transport lipid analogues, but probably not major natural membrane lipids. Both transporters can transport a wide range of hydrophobic drugs and may see lipid analogues as just another drug. The MDR3 gene probably arose in evolution from a drug-transporting P-glycoprotein gene. Recent work has shown that the phosphatidylcholine translocator has retained significant drug transport activity and that this transport is inhibited by inhibitors of drug-transporting P-glycoproteins. Whether the phosphatidylcholine translocator also functions as a transporter of some drugs in vivo remains to be seen. Three other ABC transporters were recently shown to be involved in lipid transport: ABCR, also called Rim protein, was shown to be defective in Stargardt's macular dystrophy; this protein probably transports a complex of retinaldehyde and phosphatidylethanolamine in the retina of the eye. ABC1 was shown to be essential for the exit of cholesterol from cells and is probably a cholesterol transporter. A third example, the ABC transporter involved in the import of long-chain fatty acids into peroxisomes, is discussed in the chapter by Hettema and Tabak in this volume.  (+info)

Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. (8/872)

Tangier disease, a condition characterized by low levels of high density lipoprotein and cholesterol accumulation in macrophages, is caused by mutations in the ATP-binding cassette transporter ABC1. In cultured macrophages, ABC1 mRNA was induced in an additive fashion by 22(R)-hydroxycholesterol and 9-cis-retinoic acid (9CRA), suggesting induction by nuclear hormone receptors of the liver X receptor (LXR) and retinoid X receptor (RXR) family. We cloned the 5'-end of the human ABC1 transcript from cholesterol-loaded THP1 macrophages. When transfected into RAW macrophages, the upstream promoter was induced 7-fold by 22(R)-hydroxycholesterol, 8-fold by 9CRA, and 37-fold by 9CRA and 22(R)-hydroxycholesterol. Furthermore, promoter activity was increased in a sterol-responsive fashion when cotransfected with LXRalpha/RXR or LXRbeta/RXR. Further experiments identified a direct repeat spaced by four nucleotides (from -70 to -55 base pairs) as a binding site for LXRalpha/RXR or LXRbeta/RXR. Mutations in this element abolished the sterol-mediated activation of the promoter. The results show sterol-dependent transactivation of the ABC1 promoter by LXR/RXR and suggest that small molecule agonists of LXR could be useful drugs to reverse foam cell formation and atherogenesis.  (+info)

Retinoic acids regulate the reverse cholesterol transport by inducing the ATP binding cassette transporter A1 (ABCA1) dependent cholesterol efflux in macrophages, neuronal as well as intestine cells. In the present study, we aim to test the effect of all trans retinoic acid (ATRA) on ABCA1 expression in human CD4+ T cells and the involvement of cholesterol in ATRA mediated anti-HIV effect. Treatment with ATRA dramatically up-regulated ABCA1 expression in CD4+ T cells in a time and dose dependent manner. The expression of ABCA1 paralleled with increased ABCA1-dependent cholesterol efflux. This induction was dependent on T cell receptor (TCR) signaling and ATRA failed to induce ABCA1 expression in resting T cells. Moreover, ATRA and liver X receptor (LXR) agonist-TO-901317 together had synergistic effect on ABCA1 expression as well as cholesterol efflux. Increased ABCA1 expression was associated with lower cellular cholesterol staining. Cells treated with either ATRA or TO-901317 were less vulnerable to
Inappropriate and sustained signaling events interfere with homeostasis by perturbing regulatory network function, resulting in chronic disease. In atherosclerosis, these signals arise from chronic inflammation and inhibit the macrophage homeostatic response to hyperlipidemia, specifically the cholesterol efflux pathway, which results in foam cell formation and plaque progression. While LXRs directly induce transcription of the transporters responsible for cholesterol efflux, it currently remains unknown whether additional transcriptional regulatory proteins are recruited to these promoters by inflammatory signals to block LXR‐dependent gene regulation, and the mechanisms by which this might occur.. We hypothesized that LXR cofactors receive these inflammatory signals from TLRs to directly modulate lipid‐mediated gene expression. We therefore characterized the occupancy of the Abca1 promoter by transcriptional regulators using promoter enrichment‐quantitative mass spectrometry (PE‐QMS). ...
The ABCA1 protein plays a pivotal role in reverse cholesterol transport, by mediating the generation of HDL particles and removing cellular cholesterol. Both the proper expression of ABCA1 in the plasma membrane and the internalization along with apoA-I are required for function. Therefore, we developed a model system to investigate the effect of clinically relevant drugs on the cell surface appearance of ABCA1. By retroviral transduction system, we established stable mammalian cell lines expressing functional and non-functional ABCA1 variants, tagged with an extracellular hemagglutinin epitope. After characterization of the expression, proper localization and function of different ABCA1 variants, we followed quantitatively their cell surface expression by immunofluorescent staining, using flow cytometry. As expected, we found increased cell surface expression of ABCA1 after treatment with a calpain inhibitor, and observed a strong decrease in plasma membrane ABCA1 expression upon treatment with a trans
Mitch Leslie http://sageke.sciencemag.org/cgi/content/abstract/sageke;2002/34/nw121 Key Words: ATP binding cassette transporters apolipoprotein E LDL receptor. Abstract: After you wash down a delectable cream-filled doughnut with a swig of cappuccino, cells in your arteries could also start gorging on fat, setting the stage for atherosclerosis. A new study suggests that coaxing these plaque-spawning cells to spit out their excess cholesterol might prevent heart disease. The discovery could lead to the development of drugs that thwart atherosclerosis by blocking the first step in plaque formation.. Best known for slurping up bacteria, immune cells called macrophages also eat cholesterol, helping govern its concentration in the blood. Atherosclerosis starts when macrophages binge. The cells slip into the wall of an artery, perhaps drawn by an injury. Once ensconced in the vessel, they fill up on cholesterol, triggering the growth of fatty deposits on the vessel walls that can eventually reduce or ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
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SEQUENCE 1617 AA; 184286 MW; 73940D8050B0A3CA CRC64; MNMKQKSVYQ QTKALLCKNF LKKWRMKRES LLEWGLSILL GLCIALFSSS. MRNVQFPGMA PQNLGRVDKF NSSSLMVVYT PISNLTQQIM NKTALAPLLK. GTSVIGAPNK THMDEILLEN LPYAMGIIFN ETFSYKLIFF QGYNSPLWKE. DFSAHCWDGY GEFSCTLTKY WNRGFVALQT AINTAIIEIT TNHPVMEELM. SVTAITMKTL PFITKNLLHN EMFILFFLLH FSPLVYFISL NVTKERKKSK. NLMKMMGLQD SAFWLSWGLI YAGFIFIISI FVTIIITFTQ IIVMTGFMVI FILFFLYGLS LVALVFLMSV LLKKAVLTNL VVFLLTLFWG CLGFTVFYEQ. LPSSLEWILN ICSPFAFTTG MIQIIKLDYN LNGVIFPDPS GDSYTMIATF. SMLLLDGLIY LLLALYFDKI LPYGDERHYS PLFFLNSSSC FQHQRTNAKV. IEKEIDAEHP SDDYFEPVAP EFQGKEAIRI RNVKKEYKGK SGKVEALKGL. LFDIYEGQIT AILGHSGAGK SSLLNILNGL SVPTEGSVTI YNKNLSEMQD. LEEIRKITGV CPQFNVQFDI LTVKENLSLF AKIKGIHLKE VEQEVQRILL ELDMQNIQDN LAKHLSEGQK RKLTFGITIL GDPQILLLDE PTTGLDPFSR. DQVWSLLRER RADHVILFST QSMDEADILA DRKVIMSNGR LKCAGSSMFL. KRRWGLGYHL SLHRNEICNP EQITSFITHH IPDAKLKTEN KEKLVYTLPL. ERTNTFPDLF SDLDKCSDQG VTGYDISMST LNEVFMKLEG QSTIEQDFEQ. VEMIRDSESL NEMELAHSSF SEMQTAVSDM GLWRMQVFAM ...
Human ABCA1 partial ORF ( NP_005493, 86 a.a. - 185 a.a.) recombinant protein with GST-tag at N-terminal. (H00000019-Q01) - Products - Abnova
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[51 Pages Report] Check for Discount on ATP Binding Cassette Sub Family A Member 1 (ATP Binding Cassette Transporter 1 or ABC 1 or ATP Binding Cassette 1 or Cholesterol Efflux Regulatory Protein or ABCA1) - Pipeline Review, H1 2016 report by Global Markets Direct. Global Markets Directs, ATP Binding Cassette Sub...
specificalPrinciple of the Assay: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to ATP Binding Cassette Transporter C3 (ABCC3). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to ATP Binding Cassette Transporter C3 (ABCC3). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain ATP Binding Cassette Transporter C3 (ABCC3), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of ATP Binding Cassette Transporter C3 (ABCC3) in the samples is then determined by comparing the ...
Cholesterol is an essential molecule that mediates a myriad of critical cellular processes, such as signal transduction in eukaryotes, membrane fluidity, and steroidogenesis. As such it is not surprising that cholesterol homeostasis is tightly regulated, striking a precise balance between endogenous synthesis and regulated uptake/efflux to and from extracellular acceptors. In mammalian cells, sterol efflux is a key component of the homeostatic equation and is mediated by members of the ATP binding cassette (ABC) transporter superfamily. ATP-binding cassette (ABC) transporters represent a group of evolutionarily highly conserved cellular transmembrane proteins that mediate the ATP-dependent translocation of substrates across membranes. Members of this superfamily, ABCA1 and ABCG1, are key components of the reverse cholesterol transport pathway. ABCG1 acts in concert with ABCA1 to maximize the removal of excess cholesterol from cells by promoting cholesterol efflux onto mature and nascent HDL particles
Methods and Results-Adipocyte-specific ABCA1 knockout mice (ABCA1−A/−A) were generated by crossing ABCA1floxed mice with aP2 Cre transgenic mice. AT from ABCA1−A/−A mice had ,10% of wild-type ABCA1 protein expression but normal hepatic and intestinal expression. Deletion of adipocyte ABCA1 resulted in a significant decrease in plasma HDL cholesterol (≈15%) and apolipoprotein A-I (≈13%) concentrations. AT from ABCA1−A/−A mice had a 2-fold increase in free cholesterol content compared with wild-type mice and failed to efflux cholesterol to apolipoprotein A-I. However, cholesterol efflux from AT to plasma HDL was similar for both genotypes of mice. Incubation of wild-type AT explants with apolipoprotein A-I resulted in the formation of multiple discrete-sized nascent HDL particles ranging in diameter from 7.1 to 12 nm; similar incubations with ABCA1−A/−A AT explants resulted in nascent HDL ,8 nm. Plasma decay and tissue uptake of wild-type 125I-HDL tracer were similar in both ...
Much evidence has pointed toward a potential contribution of adipose in mediating HDL lipidation. Adipose tissue is the major store for cholesterol within the body, and therefore represents a large pool of substrate to support HDL biogenesis. Adipose tissue expresses high levels of key cholesterol transporters ABCA1 and scavenger receptor class B type I (SR-BI; but not ABCG1),14 providing a gateway for cholesterol to efflux onto HDL. Expression of both ABCA1 and SR-BI increases during adipogenesis and adipocytes support HDL lipidation in vitro.14 Furthermore, adipocytes promote HDL lipidation in vivo, and the absence of either adipocyte ABCA1 or SR-BI impairs this process.14 ABCA1−/− adipocytes exhibited impaired efflux to apoA-I in vitro, but unaltered efflux to HDL, whereas SR-BI−/− adipocytes effluxed normally to apoA-I but failed to efflux to HDL. ABCG1−/− adipocytes exhibited normal efflux to both HDL and apo-A1, and protein levels were negligible in wild-type adipocytes.14 ...
The release of substrate into the translocation pathway of an ABC transporter is undoubtedly coupled to conformational changes in the binding protein (5, 7). In the absence of transporter, binding proteins such as the maltose binding protein (MBP) exhibit large hinge and twist movements of one lobe relative to the other between the liganded and unliganded states (7). In contrast, binding proteins such as BtuF and FhuD with a backbone α-helix are thought to be less likely to undergo such motions (18-20). Recently, the structure of one such binding protein, T. pallidum TroA, was solved with (19) and without (26) bound Zn2+. The difference between liganded and unliganded TroA was indeed found to be a mere 4° tilting of the C-terminal domain about the long axis of the protein without bending or unwinding of the backbone helix. This movement is very different from that observed for MBP and yet the result is a partial collapse of the binding site and the loss of the proper coordination geometry for ...
Cholesterol efflux capacity (CEC) may improve atherosclerotic cardiovascular disease (ASCVD) risk prediction beyond using coronary artery calcium (CAC), family history and high-sensitivity C-reactive protein (hs-CRP), according to a study published May 23 in the Journal of the American College of Cardiology. Purav Mody, MD, and colleagues examined 1,972 participants in the Dallas Heart Study who were free of ASCVD at baseline. Participants completed risk factor assessment, laboratory testing, imaging studies and CAC scans. Results showed that prevalent CAC (,0) was found in 52 percent of participants, family history and premature family history were reported in 31 percent and 10 percent of participants, respectively, and hs-CRP ,2 mg/l was found in 58 percent of participants. Over a median follow-up of 9.4 years, 97 participants experienced a first ASCVD event. Those with CEC more than the median vs. less than the median had a decreased risk of ASCVD (3.1 percent vs. 6.7 percent; p = 0.0003). In ...
During the past years, we and others discovered a series of human ATP-binding cassette (ABC) transporters, now referred to as ABC A-subfamily transporters. Recently, a novel testis-specific ABC A transporter, Abca17, has been cloned in rodent. In this study, we report the identification and characterization of the human ortholog of rodent Abca17. The novel human ABC A-transporter gene on chromosome 16p13.3 is ubiquitously expressed with highest expression in glandular tissues and the heart. The new ABC transporter gene exhibits striking nucleotide sequence homology with the recently cloned mouse (58%) and rat Abca17 (51%), respectively, and is located in the syntenic region of mouse Abca17 indicating that it represents the human ortholog of rodent Abca17. However, unlike in the mouse, the full-length ABCA17 transcript (4.3 kb) contains numerous mutations that preclude its translation into a bona fide ABC transporter protein strongly suggesting that the human ABCA17 gene is a transcribed pseudogene
The transport of molecules across lipid membranes is an essential function of all living organisms. One of the families of genes that have evolved to carry out this function is that which encodes the ATP-binding cassette proteins. These molecules use active transport to pump specific molecules acros …
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
description?: oligopeptide ABC superfamily ATP binding cassette transporter, membrane protein. descriptions from strain specific annotations: ...
Rat anti Mouse ABCA7 antibody, clone 4A7-144.1 recognizes murine adenosine triphosphate (ATP) Binding cassette transporter 7 (ABCA7). The
Andreas W. Jehle, Shyra J. Gardai, Suzhao Li, Patrick Linsel-Nitschke, Konosuke Morimoto, William J. Janssen, R. William Vandivier, Nan Wang, Steven Greenberg, Benjamin M. Dale, Chunbo Qin, Peter M. Henson, Alan R. Tall ...
Results presented in this report demonstrate that LXR agonists inhibit HIV-1 replication. This inhibition correlated with the stimulation of cholesterol efflux in HIV-infected cells. This anti-HIV effect of LXR agonists relied on ABCA1 and combined cholesterol-dependent and independent events. Cholesterol-dependent mechanisms include diminished virus production and reduced fusogenic ability of virions because of a reduction of virion-associated cholesterol. ABCA1 has additional suppressive effect on Nef-positive virus, probably because of its binding to Nef (Mujawar et al., 2006) and inhibiting the postentry functions of Nef in HIV infectivity, such as facilitation of intracytoplasmic transport (Qi and Aiken, 2008). The anti-HIV activity of ABCA1 explains the benefit that the virus gains by specifically targeting ABCA1 via Nef (Mujawar et al., 2006).. Nef and ABCA1 interact with each other and exist in a state of a dynamic balance: under normal infection conditions, Nef inhibits ABCA1 activity ...
Complete information for ABCA7 gene (Protein Coding), ATP Binding Cassette Subfamily A Member 7, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Lipid Rich Plaque by Coronary Computed Tomography Angiography Associates With Cholesterol Efflux Capacity Independent of Traditional Cardiovascular Risk Factors in Those at Risk for Myocardial Infarction ...
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
Predicted to have ATP binding activity and ATPase-coupled transmembrane transporter activity. Predicted to be involved in cholesterol efflux. Predicted to localize to plasma membrane. Orthologous to human ABCG4 (ATP binding cassette subfamily G member 4 ...
Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 9 (ABCA9), transcript variant 2, mRNA. (H00010350-R02) - Products - Abnova
ABCA1 expression and co-localization with [1-93]ApoA-I and ApoA-I. (A) Western blot analysis with anti-ABCA1 antibodies of cell lysates prepared from HepG2 ce
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TY - JOUR. T1 - ATP-binding cassette transporter A1 (ABCA1) R219K (G1051A, rs2230806) polymorphism and serum high-density lipoprotein cholesterol levels in a large Japanese population. T2 - Cross-sectional data from the Daiko study. AU - Mokuno, Junichiro. AU - Hishida, Asahi. AU - Morita, Emi. AU - Sasakabe, Tae. AU - Hattori, Yuta. AU - Suma, Shino. AU - Okada, Rieko. AU - Kawai, Sayo. AU - Naito, Mariko. AU - Wakai, Kenji. PY - 2015/4/11. Y1 - 2015/4/11. N2 - Among polymorphisms in ATP-binding cassette transporter Al (ABCA1) gene, the available evidence demonstrates that the ABCA1 R219K polymorphism (G1051A, rs2230806) K allele is associated with a higher high-density lipoprotein cholesterol (HDL- C) level and may play a protective role against coronary artery disease (CAD) risk in Asians and Caucasians. The findings from many underpowered studies from Asian countries (n=71-597), however, still remain inconsistent. The objective of this study was to overcome the limitations of previous ...
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In this study, we performed a mutation analysis of the ABCR gene of 80 unrelated AMD patients and 100 race and age matched control subjects. Of 51 exons of the ABCR gene, 10 that have been reported to have AMD associated mutations were studied.3 The only missense mutation found was a T1428M mutation in exon 29. Allikmetset al reported that this mutation was found in one of 167 AMD patients, and that no such mutation was found in the general population.3 However, in our series, seven of 80 (8.8%) AMD patients and eight of 100 (8.0%) of the control group did, in fact, showed this mutation (Table 1), which was not a statistically significant difference. Other alterations found were mostly polymorphisms or sequence variations. These were found in exons 23, 41, 43, and did not correspond to the 13 AMD associated mutations reported by Allikmets et al.3Apparently, there is heterogeneity in the ABCR gene. Indeed, all of the AMD and the control subjects in our series showed different nucleotide sequences ...
ATP-binding cassette transporters (ABC transporters) are members of a transport system superfamily that is one of the largest and is possibly one of the oldest families with representatives in all extant phyla from prokaryotes to humans. ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated ATPases. The ATPase subunits utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to energize the translocation of various substrates across membranes, either for uptake or for export of the substrate. Most but not all uptake systems also have an extracytoplasmic receptor, a solute binding protein. Some homologous ATPases function in non-transport-related processes such as translation of RNA and DNA repair. ABC transporters are considered to be with the ABC superfamily based on the sequence and organization of their ATP-binding cassette (ABC) domains, even though the integral membrane proteins ...
To assess the effects of ustekinumab, as compared to placebo, at Week 12 (RCT period) in patients with moderate to severe psoriasis on Cholesterol efflux capacity, and assess global change at end study (Week 52 for Ustekinumab arm, Week 64 for Placebo arm; active treatment period).. The ability to promote cholesterol efflux from macrophages is a classic function of HDL that is thought to be an important mechanism by which HDL protects against atherosclerosis. HDL cholesterol efflux capacity assays are performed based on published methods using J774 cells derived from a murine macrophage cell line (Mehta NN Atherosclerosis 2012). Efflux is calculated as a unitless measure by using the following formula: [(µCi of 3H-cholesterol in media containing apoB-depleted subject plasma - µCi of 3H-cholesterol in plasma-free media) / (µCi of 3H-cholesterol in media containing apoB-depleted pooled control plasma-µCi of 3H-cholesterol in pooled control plasma-free media)]. ...
The clearance of apoptotic cells occurs throughout the lifespan of multicellular organisms and is important for development during embryogenesis, the maintenance of tissue integrity and function, and the resolution of inflammation (deCathelineau and Henson, 2003). Here, we report that macrophage ABCA7 enhances the clearance of apoptotic cells in vitro and in vivo. ABCA7 and LRP1 move to the cell surface after stimulation with C1q or apoptotic cells and localize to membrane ruffles or phagocytic cups, respectively. However, ABCA7 also localizes to phagocytic membranes during FcR-mediated phagocytosis, in which ABCA7 levels are not rate limiting. More important, ABCA7 is required for optimal ligand-induced signaling through LRP1, as shown by C1q-induced ERK phosphorylation and for sustained ERK phosphorylation during phagocytosis of apoptotic cells. Finally, ERK phosphorylation itself is shown to be essential for phagocytosis of apoptotic cells but not for FcR-mediated phagocytosis, suggesting a ...
Background. Our aim was to determine whether the common variants within the coding sequence of ABCA1 gene affects low plasma high-density lipoprotein cholesterol (HDL-C) levels in Turkish patients with coronary artery disease (CAD). The study group was composed of 552 CAD patients, of which 251 had HDL-C levels 40 mg/dL. ...
The historical introductory chapter brings home the almost startling rapidity with which the field has developed. Less than half a century ago it was first understood that bile secretion was an active process which could be sustained against a pressure gradient in contradistinction to urine. The energy which drives secretion is now known to emanate from an array of ATP binding cassette transporters responsible for secretion of osmotically active bile solutes. Many of those transporters have been cloned and characterised and disease associations worked out.. Similarly, the function and feedback regulation of a host of genes whose products contribute to the composition and secretion of bile is explained, along with the changes induced by various cholestatic perturbations. The scope of the book is comprehensive, including all aspects of cell physiology pertinent to bile formation for the hepatocyte and cholangiocyte, and extensive data on the causes and consequences of cholestasis. The basic ...
ATP Binding Cassette Sub Family B member 1 (ABCB1 or P-Glycoprotein or P-gp) Inhibitors -Pipeline Insights, 2016 SUMMARY DelveInsights,
Fingerprint Dive into the research topics of Increased cholesterol efflux in apolipoprotein AI (ApoAI)-producing macrophages as a mechanism for reduced atherosclerosis in ApoAI,sup,(-/-),/sup, mice. Together they form a unique fingerprint. ...
Predicted to have ATPase-coupled transmembrane transporter activity and lipid transporter activity. Involved in neutral lipid metabolic process. Localizes to endoplasmic reticulum. Orthologous to human ABCA17P (ATP binding cassette subfamily A member 17, pseudogene ...
学位の種類: 博士(医学). 報告番号: 甲第4124号. 学位記番号: 新大院博(医)甲第691号. 学位授与年月日: 平成28年3月23日
ABCG2 antibody [BXP-21] (ATP binding cassette subfamily G member 2 (Junior blood group)) for FACS, ICC/IF, IHC-Fr, IHC-P, WB. Anti-ABCG2 mAb (GTX23380) is tested in Human samples. 100% Ab-Assurance.
P-糖蛋白(P-gp)是ABC(ATP binding cassette)转运体家族重要成员,也是药物在机体内转运的重要载体。本文考察PKC/NF-κB-PXR信号途径对LS174T细胞中P-gp基因表达的调控作用。运用孕甾烷X受体(PXR)-MDR1双荧光报告基因实验探究PKC激动剂佛波酯(PMA)对LS174T细胞中MDR1荧光素酶活性的影响;分别采用real-time qPCR和Western blot检测PMA对LS174T细胞中P-gp mRNA表达、蛋白表达及NF-κB通路相关蛋白的影响。结果表明,PKC激动剂PMA能明显抑制PXR介导的P-gp荧光素酶活性、mRNA和蛋白表达,并能显著性增加胞内RelA/p65的核转位。此外,siRNA干扰实验结果显示,PKCα siRNA、RelA siRNA或PXR siRNA干扰均可显著削弱PMA对P-gp基因表达的下调作用。因此,PKC激动剂能显著抑制PXR介导的P-gp基因表达并伴随NF-κB激活,提示PKC/NF-κB-PXR信号通路对P-gp基因表达具有重要的调控作用 ...
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Oh yes, They do wham and bam. Especially in the hands of a preschool boy. Amazingly, his wham bam usage trials yielded no lasting it snapped me! injuries or breakage ...
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Mint =เหมือนใหม่ เพิ่งแกะซีล ดูแล้วเหมือนไม่มีร่องรอยการเล่น หรือผ่านการเล่นมาน้อยมา ...
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl channel (CLCN3). ATP-binding cassette transporter ... Dean M, Rzhetsky A, Allikmets R (July 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Research. ... "Entrez Gene: ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2". Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y (2012 ...
ATP-binding cassette transporter sub-family C member 11, also MRP8 (Multidrug Resistance-Related Protein 8) is a membrane ... ATP-binding cassette transporter Body odor GRCh38: Ensembl release 89: ENSG00000121270 - Ensembl, May 2017 "Human PubMed ... Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Research. 11 ... The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ...
ATP-binding cassette transporter 12 층판상 어린선, type 3 604777 CYP4F22 Cytochrome P450, subfamily 4F, polypeptide 22 ... Emopamil binding protein Ichthyosis follicularis with alopecia and photophobia syndrome 308205 MBTPS2 Membrane-bound ... 이상혁 외 4인 (9.24). 》206p》. 》어린선 환자에서 발생한 혈관면역모세포 T세포림프종 1예》 (PDF) (학위논문).. 다음 날짜 값 확인 필요: ,date=, ,연도=와 ,날짜=가 일치하지 않음. (도움말) ... 아종에 관계없이 모든 어린선 환자들은 마르고 딱딱하며 얇은 비늘 모양의 피부를 띤다.[1] 어린선은 물고기를 의미하는 그리스어ichthys에서 유래된 명칭으로 전신에 물고기 비늘같은 인설(scale)을 보이는 질환을 총칭하는 ...
Putative ATP-binding cassette transporter sub-family C member 13 is a protein that is not present in humans. In humans, ABCC13 ... ATP-binding cassette transporter ABCC13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) ... This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport ... Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates". Annual Review of ...
Löscher, Wolfgang; Potschka, Heidrun (2005-01-01). "Blood-brain barrier active efflux transporters: ATP-binding cassette gene ... Löscher, Wolfgang; Potschka, Heidrun (2005-05-01). "Role of drug efflux transporters in the brain for drug disposition and ... "Drug resistance in brain diseases and the role of drug efflux transporters". Nature Reviews Neuroscience. 6 (8): 591-602. doi: ... 76 (1): 22-76. doi:10.1016/j.pneurobio.2005.04.006. ISSN 0301-0082. PMID 16011870. S2CID 38977116. "Wolfgang Loscher". www.epi. ...
"ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol ... ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid ... The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... ATP-binding cassette transporter GRCh38: Ensembl release 89: ENSG00000064687 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
"The ATP/Substrate Stoichiometry of the ATP-binding Cassette (ABC) Transporter OpuA". Journal of Biological Chemistry. Retrieved ... He is an expert in the field of ATP-binding cassette transporters, one of the largest known protein families, by combining ... Van Der Heide, Tiemen; Poolman, Bert (2002). "ABC transporters: one, two or four extracytoplasmic substrate‐binding sites?". ... His group was the first to show that changes in the ionic strength are used to gate the activity of osmoregulatory transporters ...
ATP-binding cassette transporter GRCh38: Ensembl release 89: ENSG00000172350 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... The protein encoded by this gene is included in the ATP-binding cassette transporter (ABC protein) superfamily. ABC proteins ... Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res. 11 (7 ... 2002). "Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4". Gene. 293 (1-2): 67-75 ...
"The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease". Nature Genetics. 22 (4): 347-51. doi: ... Lea OA (October 1988). "Binding properties of progesterone-binding Cyst protein, PBCP". Steroids. 52 (4): 337-8. doi:10.1016/ ... A very poor binding between ApoD and cholesterol has also been observed. Other ApoD ligands include E-3-methyl-2-hexenoïc acid ... This binding property was then demonstrated experimentally. Arachidonic acid (AA) was identified as an ApoD ligand with a much ...
ATP binding cassette) transporter: MDR, CFTR, etc. Adenosine triphosphate-binding cassette transporters (ABC transporters) ... ATP-binding cassette transporter Countercurrent exchange Protein targeting Translocation "The importance of homeostasis". ... including two nucleotide-binding domains that constitute the ATP-binding motif and two hydrophobic transmembrane domains that ... One example of this type of ABC transporter is the protein NtPDR1. This unique ABC transporter is found in Nicotiana tabacum ...
ATP-binding cassette transporter TAP1 has been shown to interact with: HLA-A, and Tapasin. ENSG00000168394, ENSG00000224212, ... A member of the ATP-binding cassette transporter family, it is also known as ABCB2. The membrane-associated protein encoded by ... this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules ... ATP-binding cassette, sub-family B (MDR/TAP)". Paulsson KM, Kleijmeer MJ, Griffith J, Jevon M, Chen S, Anderson PO, Sjogren HO ...
"Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)". Townsend A, Trowsdale J (1993). "The ... ATP-binding cassette transporter ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ... The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ... Cano P, Baxter-Lowe LA (1995). "Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain". Tissue ...
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... membrane-spanning domain that sets it apart from other transporters within the ATP-binding cassette family of transporters. The ... ATP-binding cassette transporter P-glycoprotein (Multidrug resistance protein- MDR1). Not to be confused with Multidrug ... ATP-binding Cassette (ABC) Transporter". Journal of Biological Chemistry. 289 (45): 30880-30888. doi:10.1074/jbc.R114.609248. ...
"Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters ... "ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and ... The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... Gärtner J, Valle D (1993). "The 70 kDa peroxisomal membrane protein: an ATP-binding cassette transporter protein involved in ...
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... toxin transporter activity. • protein binding. • protein heterodimerization activity. • phospholipid binding. • ATP binding. • ... "Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease". Biochemical and Biophysical Research ... ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene.[5][6][7] It is a homolog ...
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ... Matsumura Y, Ban N, Ueda K, Inagaki N (2006). "Characterization and classification of ATP-binding cassette transporter ABCA3 ... It is associated with Surfactant metabolism dysfunction type 3. ATP-binding cassette transporter GRCh38: Ensembl release 89: ... "Entrez Gene: ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3". Chen, P; Dai, Y; Wu, X; Wang, Y; Sun, S; Xiao, J; ...
Her research focuses on elucidating the structure and function of ATP-binding cassette (ABC) transporters. Chen was born in ... where she started studying the ATP binding cassette transporters In 2002, Chen became an assistant professor at Purdue ... "A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle". Molecular Cell. 12 (3): 651-661. doi: ... Her work on ABC transporters includes investigating their role in resistance to chemotherapy drugs; antigen presentation in ...
Cholesterol from non-hepatic peripheral tissues is transferred to HDL by the ABCA1 (ATP-binding cassette transporter). ... Apolipoprotein A1 (ApoA-1), the major protein component of HDL, acts as an acceptor, and the phospholipid component of HDL acts ...
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ... ATP-binding cassette transporter GRCh38: Ensembl release 89: ENSG00000115657 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... 2002). "Isolation of a genomic clone containing the promoter region of the human ATP binding cassette (ABC) transporter, ABCB6 ... 1997). "Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during ...
"Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)". J ... The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ... ATP-binding cassette transporter GRCh38: Ensembl release 89: ENSG00000150967 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... ATP-binding cassette sub-family B member 9 is a protein that in humans is encoded by the ABCB9 gene. ...
... is an ATPase that is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 ... "The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is ... RLI has two C-terminal ABC domains; upon binding ATP they form a characteristic "ATP-sandwich," with two ATP molecules ... ATP-binding cassette sub-family E member 1 (ABCE1) also known as RNase L inhibitor (RLI) is an enzyme that in humans is encoded ...
Genes under the control of malT include ATP-binding cassette transporter components, maltoporin, maltose binding protein, and ... MalT binds to maltose or maltodextrin and undergoes a conformational change that allows it to bind DNA at sequences near the ... 62 (1): 204-29. doi:10.1128/MMBR.62.1.204-229.1998. PMC 98911. PMID 9529892. Clark, David P.; Pazdernik, Nanette; MeGehee, ... Afzal, Muhammad; Shafeeq, Sulman; Manzoor, Irfan; Kuipers, Oscar P. (1 June 2015). "Maltose-Dependent Transcriptional ...
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... Kajinami K, Brousseau ME, Nartsupha C, Ordovas JM, Schaefer EJ (Apr 2004). "ATP binding cassette transporter G5 and G8 ... "Mutations in the human ATP-binding cassette transporters ABCG5 and ABCG8 in sitosterolemia". Human Mutation. 20 (2): 151. doi: ... "Entrez Gene: ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1)". Schmitz G, Langmann T, Heimerl S (Oct ...
ERβ function is related to various cardiovascular targets including ATP-binding cassette transporter A1 (ABCA1) and ... The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus ... "The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their ... Upon binding to 17-β-estradiol, estriol or related ligands, the encoded protein forms homo-dimers or hetero-dimers with ...
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... ATP-binding cassette transporter ENSG00000225989, ENSG00000236149, ENSG00000232169, ENSG00000204574, ENSG00000236342, ... "Entrez Gene: ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1". Klein I, Sarkadi B, Váradi A (2000). "An inventory of ... ATP-binding cassette sub-family F member 1 is a protein that in humans is encoded by the ABCF1 gene. ...
2002). "The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex". ... Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene. Aldehyde oxidase produces hydrogen peroxide and, ... 48 (1): 197-200. doi:10.1016/0006-2952(94)90240-2. PMID 8043023. Wright RM, Vaitaitis GM, Wilson CM, et al. (1993). "cDNA ... "Entrez Gene: aldehyde oxidase 1". Berger R, Mezey E, Clancy KP, Harta G, Wright RM, Repine JE, Brown RH, Brownstein M, ...
1999). "Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the ... ISBN 1-55581-222-8. Remaley, AT; Rust, S; Rosier, M; Knapper, C; Naudin, L; Broccardo, C; Peterson, KM; Koch, C; et al. ( ... 276 (1): 34-42 contd. doi:10.1056/NEJM196701052760107. PMID 5333081. Stanbury JB, Wyngaarden JB, Fredrickson DS (Eds). The ...
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ... ATP-binding cassette transporter GRCh38: Ensembl release 89: ENSG00000107331 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Davis W, Boyd JT, Ile KE, Tew KD (2004). "Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density ... 2001). "Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2". ...
Buechler C, Boettcher A, Bared SM, Probst MC, Schmitz G (2002). "The carboxyterminus of the ATP-binding cassette transporter A1 ... "The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex". Biochem. ... and each bind to dystrophin and its relatives". J Biol Chem. 271 (5): 2724-30. doi:10.1074/jbc.271.5.2724. PMID 8576247. Ahn AH ... "The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta- ...
ATP-binding cassette transporter. *ABCA1. *ABCG5. *ABCG8. This article on a gene on human chromosome 19 is a stub. You can help ... lipid transporter activity. Cellular component. • high-density lipoprotein particle. • extracellular region. • very-low-density ... 7 (1): 143-54. doi:10.1002/pmic.200600339. PMID 17154273.. *. Lowe JK, Maller JB, Pe'er I, et al. (2009). Gibson G, ed. "Genome ... doi:10.1016/S0021-9150(99)00459-1. PMID 10996355.. *. Klos KL, Sing CF, Boerwinkle E, et al. (2006). "Consistent effects of ...
The Human ATP-Binding Cassette (ABC) Transporter Superfamily. Bethesda (MD):National Library of Medicine (US), NCBI; 2002 ... Matsson, P. ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition. Acta ... Az ABC-transzporterek (ATP-binding casette transporters ATP-kötő kazetta transzporterek) az egyik legnagyobb és legősibb ... A szupercsalád tagjait az ATP-kötő doménjük (vagy doménjeik) -más néven NBF (nucleotide binding fold)- aminosavsorrendje és ...
ATP binding cassette (ABC) type transporters are common to all the three domains of life. The Sec system constituting the Sec Y ... The process begins as a leader sequence HlyA is recognized and binds HlyB on the membrane. This signal sequence is extremely ... Thanassi DG, Stathopoulos C, Karkal A, Li H (2005). "Protein secretion in the absence of ATP: the autotransporter, two-partner ... ISBN 978-1-904455-42-4.. [page needed] *^ Boyd CD, Smith TJ, El-Kirat-Chatel S, Newell PD, Dufrêne YF, O'Toole GA (August 2014 ...
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters ... transporter activity. • ATPase activity. • GO:0001948 protein binding. • ATP binding. • ATPase-coupled transmembrane ... ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene.[5][6] ABCG2 has also ... ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2".. *^ a b c d Vlaming ML, Lagas JS, Schinkel AH (January 2009). " ...
ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters ... ATP-binding cassette transporters (ABC transporters) are members of a transport system superfamily that is one of the largest ... Each member of the ABCF subgroup consist of a pair of ATP binding domains. Six half transporters with ATP binding sites on the ... Dimer formation of the two ABC domains of transporters requires ATP binding. It is generally observed that the ATP bound state ...
... s express transporters of the ATP-binding cassette family that actively pump a diversity of organic molecules ... 1 (1): 74-79. doi:10.1002/term.8. PMID 18038395.. *^ Centeno; et al. "Regeneration of meniscus cartilage in a knee treated with ... 19: 1-22. doi:10.1146/annurev.cellbio.19.111301.143037. PMID 14570561.. *^ Smith, S; Neaves, W; Teitelbaum, S; Prentice, D. A ... 978-1-4939-7370-5. . PMID 29030809.. *^ Baumgartner, C; Toifl, S; Farlik, M; Halbritter, F; Scheicher, R; Fischer, I; Sexl, V; ...
transportador de casete de unión ao ATP. (ATP-binding cassette transporter). ABCA1 · ABCG5 · ABCG8 ... Weisgraber KH, Innerarity TL, Mahley RW (Mar 1982). "Abnormal lipoprotein receptor-binding activity of the human E apoprotein ... APOA (1, 2, 4, 5) · APOB (ApoB100, ApoB48) · APOC (1, 2, 3, 4) · APOD · APOE · APOH. SAA (SAA1) ... 1,0 1,1 "Entrez Gene: APOE apolipoprotein E".. *↑ Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (Feb 2013). "Apolipoprotein E and ...
... a member of the ATP-binding cassette transporter superfamily. Whether MRP4 is the only transporter releasing prostaglandins ... To treat egg binding in small birds[20]. *As an ingredient in eyelash and eyebrow growth beauty products due to side effects ... The release of prostaglandin has now also been shown to be mediated by a specific transporter, namely the multidrug resistance ... The discovery of the prostaglandin transporter (PGT, SLCO2A1), which mediates the cellular uptake of prostaglandin, ...
The protein belongs to the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules ... nucleotide binding. • transporter activity. • ATPase activity. • protein binding. • hydrolase activity. • ATP binding. • ... ATP binds at the cytoplasmic side of the protein. Following binding of each, ATP hydrolysis shifts the substrate into a ... ADP is released, and a new molecule of ATP binds to the secondary ATP-binding site. Hydrolysis and release of ADP and a ...
ATP binding cassette transporterEdit. Transporting chemicals out of a cell against a gradient is often associated with ATP ... Transport is mediated by ATP binding cassette transporters. The human genome encodes 48 ABC transporters, that are used for ... Binding of metal cations to ATPEdit. Being polyanionic and featuring a potentially chelatable polyphosphate group, ATP binds ... The protein has two binding sites for ATP - the active site is accessible in either protein conformation, but ATP binding to ...
... an ATP binding cassette transporter, contributes to nonhost resistance to inappropriate pathogens that enter by direct ... 1] TAIR: About Arabidopsis *^ Rensink WA, Buell CR (June 2004). "Arabidopsis to rice. Applying knowledge from a weed to enhance ... 15 (1): 1-144.. *^ Fulgione A, Hancock AM (September 2018). "Archaic lineages broaden our view on the history of Arabidopsis ... doi:10.1016/s0169-5347(01)02291-1.. *^ Sharbel TF, Haubold B, Mitchell-Olds T (2000). "Genetic isolation by distance in ...
ATP-binding cassette transporter. *ABCA1. *ABCG5. *ABCG8. *v. *t. *e. Lipids: phospholipids ... The acetyl-CoA is then ultimately converted into ATP, CO2, and H2O using the citric acid cycle and the electron transport chain ... The energy yield of the complete oxidation of the fatty acid palmitate is 106 ATP.[97] Unsaturated and odd-chain fatty acids ... Glycolysis → Pyruvate decarboxylation → Citric acid cycle → Oxidative phosphorylation (electron transport chain + ATP synthase) ...
... a member of the ATP-binding cassette transporter superfamily. Whether MRP4 is the only transporter releasing prostaglandins ... Once inside the cell long-chain-fatty-acid-CoA ligase catalyzes the reaction between a fatty acid molecule with ATP (which is ... Each beta oxidative cut of the acyl-CoA molecule yields 5 ATP molecules. The acetyl-CoA produced by beta oxidation enters the ... Here it is converted into glycerol 3-phosphate by the action of glycerol kinase which hydrolyzes one molecule of ATP per ...
Lr34 encodes an adenosine triphosphate (ATP)-binding cassette (ABC) transporter. The dominant allele that provides disease ... The xa13 gene has a mutated effector-binding element in its promoter that eliminates PthXo1 binding and renders these lines ... Examples: Auxin: binds to receptors that then recruit and degrade repressors of transcriptional activators that stimulate auxin ... Many R genes encode NB-LRR proteins (proteins with nucleotide-binding and leucine-rich repeat domains, also known as NLR ...
The ATP-binding cassette superfamily (ABC). *The small multidrug resistance family (SMR) ... peptide transporters (PEPTs), and Na+ phosphate transporters (NPTs). These transporters are distributed along particular ... Of these, only the ABC superfamily are primary transporters, the rest being secondary transporters utilizing proton or sodium ... Bacterial efflux transporters are classified into five major superfamilies, based on their amino acid sequence and the energy ...
Fourier Transform Infrared Spectroscopy of the Nucleotide-binding Domain from the ATP-binding Cassette Transporter MsbA: ATP ... Zharova, T.V, & Vinogradov, Proton-Translocating ATP-synthase of Paracoccus denitrificans: ATP- Hydrolytic Activity. ... the hydrolysis of ATP has the effect of lowering the pH of the reaction medium. Under certain conditions, high levels of ATP ... "ATP: Adenosine Triphosphate". cnx.org. Retrieved 2018-05-16.. *^ Wackerhage, H.; Hoffmann, U.; Essfeld, D.; Leyk, D.; Mueller, ...
ATP-binding cassette transporter. *ABCA1. *ABCG5. *ABCG8. Retrieved from "https://en.wikipedia.org/w/index.php?title= ... lipid binding. Cellular component. • chylomicron. • very-low-density lipoprotein particle. • spherical high-density lipoprotein ... phospholipase binding. • protein homodimerization activity. • lipoprotein lipase activator activity. • phospholipase activator ... Click on genes, proteins and metabolites below to link to respective articles. [§ 1] ...
... which is a membrane transporter from the large ATP-binding cassette transporter family) influences the disease course is ... mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter". Proc. Natl. Acad. Sci. U.S.A. 97 ( ... Pseudoxanthoma elasticum (PXE), also known as Grönblad-Strandberg syndrome,[1] is a genetic disease that causes fragmentation ... "Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum". Nat. Genet. 25 (2): 223-7. doi:10.1038/76102 ...
transportador de casete de unión ao ATP. (ATP-binding cassette transporter). ABCA1 · ABCG5 · ABCG8 ... Huang CX, Zhang YL (2013). "The target of regulating the ATP-binding cassette A1 protein (ABCA1): promoting ABCA1-mediated ... APOA (1, 2, 4, 5) · APOB (ApoB100, ApoB48) · APOC (1, 2, 3, 4) · APOD · APOE · APOH. SAA (SAA1) ... Consultado o 1 September 2012.. *↑ Siri-Tarino PW, Sun Q, Hu FB, Krauss RM (2010). "Saturated fat, carbohydrate, and ...
ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters" ... The ATP binding cassette multidrug transporter LmrA and lipid transporter MsbA have overlapping substrate specificities". J. ... Human ATP-Binding Cassette Transporters *^ Ueda, K.; DP, Clark; CJ, Chen; IB, Roninson; Gottesman, Michael M.; I, Pastan (1987 ... Rea, P. A. (2007). „Plant ATP-binding cassette transporters". Annu Rev Plant Biol. 58: 347-75. PMID 17263663. doi:10.1146/ ...
The TFIID is the first component to bind to DNA due to binding of TBP, while TFIIH is the last component to be recruited. In ... G-Less Cassette transcription assay: measures promoter strength. *Run-off transcription assay: identifies transcription start ... Goodrich JA, Tjian R (April 1994). "Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA ... TFIIH has been recently reported as a glucose conjugate for targeting hypoxic cancer cells with increased glucose transporter ...
The ATP-binding cassette superfamily (ABC)[4]. *The small multidrug resistance family (SMR)[4] ... peptide transporters (PEPTs), and Na+ phosphate transporters (NPTs). These transporters are distributed along particular ... The duct is also bound to two other proteins: a periplasmic membrane protein and an integral membrane transporter. The ... Of these, only the ABC superfamily are primary transporters, the rest being secondary transporters utilizing proton or sodium ...
The Duffy binding protein found on Plasmodia, the one and only invasion ligand for DARC, does not bind to Saimiri erythrocytes ... anion transporter (organic) - molecules that play an essential role in the distribution and excretion of numerous endogenous ... ATP - (Adenosine triphosphate) - an organic molecule containing high energy phosphate bonds used to transport energy within a ... Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA (1996). "The dorsoventral regulatory gene cassette spätzle/Toll/ ...
This membrane-associated protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ... ATP-binding cassette, sub-family B member 11 also known as ABCB11 is a protein which in humans is encoded by the ABCB11 gene. ... The product of the ABCB11 gene is an ABC transporter named BSEP (Bile Salt Export Pump), or sPgp (sister of P-glycoprotein). ... In humans, the activity of this transporter is the major determinant of bile formation and bile flow. ABCB11 is a gene ...
SUR2A, the adenosine triphosphate (ATP)-binding cassette transporter of the IK(ATP) channel.[6] ... 18 (1): 3-12. doi:10.1038/gim.2015.35. PMID 25905440.. *^ a b c d e f g h i j k l m n o Antzelevitch C, Patocskai B (January ... 978-1-4471-4880-7. . OCLC 841465583.. *^ a b c d e f g h i j k l Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, et al ... 1 (3): 156-66. doi:10.1053/eupc.1999.0033. PMID 11225790.. *^ Nakajima K, Takeichi S, Nakajima Y, Fujita MQ (April 2011). " ...
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ... 2002). "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ... ATP-binding cassette sub-family A member 8 is a protein that in humans is encoded by the ABCA8 gene. ... "Entrez Gene: ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8". CS1 maint: discouraged parameter (link) Gerhard DS, ...
Up to 19 types of permease exist to transport various carbohydrates with 13 being ATP-binding cassette transporters. B. longum ... The persistence of B. longum in the gut is attributed to the glycoprotein-binding fimbriae structures and bacterial ... 87 (1): 10-16. doi:10.1016/j.mimet.2011.06.014. PMID 21756944. Xiao, J. Z.; Kondo, S.; Takahashi, N.; Miyaji, K.; Oshida, K.; ... 12 (1-2): 9-19. doi:10.1159/000096455. PMID 17183207. S2CID 21532161. Tanaka, H.; Hashiba, H.; Kok, J.; Mierau, I. (2000). " ...
... Nat Genet. 1999 Aug;22(4):352-5. ... in which we found the gene encoding human ATP cassette-binding transporter 1 (ABC1). We also found a change in ABC1 expression ... Our findings indicate that defects in ABC1, encoding a member of the ABC transporter superfamily, are the cause of TD. ... S Rust 1 , M Rosier, H Funke, J Real, Z Amoura, J C Piette, J F Deleuze, H B Brewer, N Duverger, P Denèfle, G Assmann ...
Most of the protein sequence features involved in binding ATP are conserved, with two exceptions: chicken TAP1 has a glycine in ... Isolation of transporter associated with antigen processing genes, TAP1 and TAP2, from the horned shark Heterodontus francisci. ... Isolation of transporter associated with antigen processing genes, TAP1 and TAP2, from the horned shark Heterodontus francisci ... Experiments performed with BMs from transporter associated with antigen processing (TAP1) knock-out mice demonstrated that the ...
The ATP-binding cassette transporter-1 (ABCA1) mediates cholesterol efflux and genotypic variation in ABCA1 and may impact ... ATP-Binding Cassette Transporters / genetics*. Cholesterol, HDL / blood*. Cohort Studies. Female. Gene Frequency. Genetic ... Genotypic variation in ATP-binding cassette transporter-1 (ABCA1) as contributors to the high and low high-density lipoprotein- ... The ATP-binding cassette transporter-1 (ABCA1) mediates cholesterol efflux and genotypic variation in ABCA1 and may impact ...
ATP-binding cassette transporter A1. ApoA-I. apolipoprotein AI. FACS. fluorescence-activated cell sorting. GFP. green ... inhibits the activity of the major cellular cholesterol transporter ATP binding cassette transporter A1 (ABCA1), suggesting ... we have reported previously that Nef inhibits the activity of the ATP-binding cassette transporter A1 (ABCA1) in HIV-infected ... Two possible mechanisms can be considered: ABCA1 may bind Nef and prevent its incorporation into virions, or ABCA1 bound to Nef ...
ATP Binding Cassette Transporter 1 or ABC 1 or ATP Binding Cassette 1 or Cholesterol Efflux Regulatory Protein or ABCA1) - ... 51 Pages Report] Check for Discount on ATP Binding Cassette Sub Family A Member 1 ( ... ATP Binding Cassette Transporter 1 or ABC 1 or ATP Binding Cassette 1 or Cholesterol Efflux Regulatory Protein or ABCA1) - Drug ... ATP Binding Cassette Transporter 1 or ABC 1 or ATP Binding Cassette 1 or Cholesterol Efflux Regulatory Protein or ABCA1) - ...
... lauric acid and kaempferol abolish ATP-binding cassette transporter subfamily A member 1 (ABCA1) down-regulation by TNF-? in ... ATP-binding cassette transporters, ABCA1 and ABCG1, are cell surface transporters that mediate the reverse cholesterol ... Siripurkpong P, Na-Bangchang K. Effects of niacin and chromium on the expression of ATP-binding cassette transporter A1 and ... Liao H, Langmann T, Schmitz G, Zhu Y. Native LDL upregulation of ATP-binding cassette transporter 1 in human vascular ...
Here we show that the solute binding protein (BlG16BP) associated with an ATP binding cassette (ABC) transporter from the ... Here we show that the solute binding protein (BlG16BP) associated with an ATP binding cassette (ABC) transporter from the ... T1 - An atp binding cassette transporter mediates the uptake of α-(1,6)-linked dietary oligosaccharides in bifidobacterium and ... An atp binding cassette transporter mediates the uptake of α-(1,6)-linked dietary oligosaccharides in bifidobacterium and ...
13C backbone resonances of the second periplasmic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter ... ATP induces conformational changes of periplasmic loop regions of the maltose ATP-binding cassette transporter. J Biol Chem 281 ... NMR assignments of the periplasmic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter. ... 13C backbone resonances of the second periplasmic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter ...
ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters ... ATP-binding cassette transporters (ABC transporters) are members of a transport system superfamily that is one of the largest ... Each member of the ABCF subgroup consist of a pair of ATP binding domains. Six half transporters with ATP binding sites on the ... Dimer formation of the two ABC domains of transporters requires ATP binding. It is generally observed that the ATP bound state ...
Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC ... CRYSTAL STRUCTURE OF A NUCLEOTIDE-FREE ATP-BINDING CASSETTE FROM AN ABC TRANSPORTER. ...
These results provide a basis for further research on ABC transporters involved in detoxification in N. lugens, and for a more ... In addition, ABCG12, which belongs to the ABC transporter G subfamily, was significantly upregulated after exposure to ... transporter superfamily is one of the largest groups of proteins and plays a non-negligible role in phase III of the ... we identified 32 ABC transporters, which are grouped into eight subfamilies (ABCA-H) based on phylogenetic analysis. The ...
Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC ... CRYSTAL STRUCTURE OF A NUCLEOTIDE-FREE ATP-BINDING CASSETTE FROM AN ABC TRANSPORTER. ... HIGH-AFFINITY BRANCHED CHAIN AMINO ACID TRANSPORT ATP-BINDING PROTEIN protein, length: 257 (BLAST) ...
Although ATP-binding cassette transporter A1 (ABCA1) is well known for its role in cholesterol efflux and HDL formation, it is ... The ATP-Binding Cassette Transporter A1 R230C Variant Affects HDL Cholesterol Levels and BMI in the Mexican Population. ... The ATP-Binding Cassette Transporter A1 R230C Variant Affects HDL Cholesterol Levels and BMI in the Mexican Population ... The ATP-Binding Cassette Transporter A1 R230C Variant Affects HDL Cholesterol Levels and BMI in the Mexican Population ...
Iron-regulated vacuolar ABC-type transporter which may be responsible for mobilizing stored iron from the vacuole to the ... sp,Q9P5N0,ABC3_SCHPO ATP-binding cassette transporter abc3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN= ... ATP-binding, Nucleotide-binding. Enzyme and pathway databases. Reactome - a knowledgebase of biological pathways and processes ... bind target=_top>More...,/a>,/p>Nucleotide bindingi. 614 - 621. ATP 1PROSITE-ProRule annotation. ,p>Manual validated ...
Homologs of other ABC transporter genes, such as CDR4, CDR6 and SNQ2, also displayed raised expression in a sub-set of clinical ... Our study has analyzed the entire complement of ABC superfamily transporters to assess whether these play a major role in drug ... Our study has analyzed the entire complement of ABC superfamily transporters to assess whether these play a major role in drug ... The capacity of ABC transporters to efflux a broad spectrum of xenobiotics represents one of the major mechanisms of clinical ...
ATP binding cassette transporter A1. ASKO. adipose-specific Abca1 knockout. BAT. brown adipose tissue. C/EBP. CCAAT/enhancer- ... E and F, 3T3L1 cells were transfected with scrambled Cntl siRNA (C) or with Abca1 (ATP-binding cassette transporter A1) siRNA ( ... A, Abca1 (ATP-binding cassette transporter A1) and GAPDH Western blots of tissues from Cntl (control), HT ASKO (heterozygous ... Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo. Circulation. ...
The Arabidopsis pxa1 Mutant Is Defective in an ATP-Binding Cassette Transporter-Like Protein Required for Peroxisomal Fatty ... The Arabidopsis pxa1 Mutant Is Defective in an ATP-Binding Cassette Transporter-Like Protein Required for Peroxisomal Fatty ... The Arabidopsis pxa1 Mutant Is Defective in an ATP-Binding Cassette Transporter-Like Protein Required for Peroxisomal Fatty ... The Arabidopsis pxa1 Mutant Is Defective in an ATP-Binding Cassette Transporter-Like Protein Required for Peroxisomal Fatty ...
ATP-Binding Cassette Transporter G26 Is Required for Male Fertility and Pollen Exine Formation in Arabidopsis. Teagen D. ... ATP-Binding Cassette Transporter G26 Is Required for Male Fertility and Pollen Exine Formation in Arabidopsis ... The ATP-binding Cassette Transporter OsABCG15 is Required for Anther Development and Pollen Fertility in Rice ... ATP-Binding Cassette Transporter G26 Is Required for Male Fertility and Pollen Exine Formation in Arabidopsis ...
Studies suggest that genetic variability of the cholesterol efflux transporter, ATP-binding cassette transporter 1 (ABCA1), ... Lee JY, Parks JS (2005) ATP-binding cassette transporter AI and its role in HDL formation. Curr Opin Lipidol 16:19-25CrossRef ... ATP-binding cassette transporter 1 (ABCA1) is a cholesterol efflux transporter that when absent increases and when ... Koldamova R, Fitz NF, Lefterov I (2010) The role of ATP-binding cassette transporter A1 in Alzheimers disease and ...
The ABCA1 gene belongs to a group of genes called the ATP-binding cassette family, which provides instructions for making ... The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet. 1999 Aug;22(4):347-51. Citation ... Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet. 1999 Aug;22(4):352-5 ... The ABCA1 gene belongs to a group of genes called the ATP-binding cassette family, which provides instructions for making ...
... binding cassette(ABC) genes encode transporters that are expressed on the cell membrane or organelle membranes and are involved ... 48 Human ATPBinding Cassette Transporters. Part of a transporter gene website with links to other websites, review articles ... The Human ATPBinding cassette (ABC) transporter superfamily. This is an online monograph on ABC genes with links to other ... The adenosine triphosphate (ATP)‐binding cassette (ABC) genes encode transporters that are expressed on the cell membrane or ...
... but is instead related to the action of ATP-binding cassette (ABC) transporters that act as ATP-dependent efflux pumps for ... The role of ATP-binding cassette (ABC) transporters in the efflux of the insecticide, temephos, was assessed in the larvae of ... Evaluation of the role of ATP-binding cassette transporters as a defence mechanism against temephos in populations of Aedes ... Multidrug resistance ABC transporters. FEBS letters 555: 102-105. [ Links ] Dermauw W, Van Leeuwen T 2014. The ABC gene family ...
The ABCG2 gene belongs to a group of genes called the ATP-binding cassette family; genes in this family provide instructions ... ATP-binding cassette transporter G2. *ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) ... The ABCG2 gene belongs to a group of genes called the ATP-binding cassette family; genes in this family provide instructions ... multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2 ...
And the R219K polymorphism at the gene of ATP-binding cassette transporter 1(ABCA1) was reported to be associated with the ... Adult , Female , Humans , Male , Young Adult , ATP-Binding Cassette Transporters/genetics , Apolipoproteins/blood , Cholesterol ... ATP-Binding Cassette Transporters Limits: Adult / Female / Humans / Male Language: English Journal: Biol. Res Journal subject: ... Effects of R219K polymorphism of ATP-binding cassette transporter 1 gene on serum lipids ratios induced by a high-carbohydrate ...
LIU, Hui et al. Effects of R219K polymorphism of ATP-binding cassette transporter 1 gene on serum lipids ratios induced by a ... And the R219K polymorphism at the gene of ATP-binding cassette transporter 1(ABCA1) was reported to be associated with the ... Keywords : Apolipoprotein; ATP-binding cassette transporter 1 gene; Gene polymorphism; High-carbohydrate [low-fat diet]; Lipid ... Body mass index (BMI), waist-to-hip ratios (WHR), log(TG/HDL-C), TC/HDL-C, LDL-C/HDL-C and apoA-1/apoB-100 were calculated. ...
... our laboratory and others demonstrated that mutations in the ATP-binding cassette transporter 1 (ABCA1) gene are responsible ... ATP-binding cassette transporter A1 locus is not a major determinant of HDL-C levels in a population at high risk for coronary ... Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary ... Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary ...
And the R219K polymorphism at the gene of ATP-binding cassette transporter 1(ABCA1) was reported to be associated with the ... Body mass index (BMI), waist-to-hip ratios (WHR), log(TG/HDL-C), TC/HDL-C, LDL-C/HDL-C and apoA-1/apoB-100 were calculated. ... apoA-1 and apoB-100 were measured on the 1st, 8th and 14th days of this study. ... Liu, H., Lin, J., Zhu, X.C. et al. Effects of R219K polymorphism of ATP-binding cassette transporter 1 gene on serum lipids ...
The ATP-Binding Cassette Transporter Subfamily A Member 1 (ABC-A1) and Type 2 Diabetes: An Association Beyond HDL Cholesterol. ... Title: The ATP-Binding Cassette Transporter Subfamily A Member 1 (ABC-A1) and Type 2 Diabetes: An Association Beyond HDL ... The ATP-Binding Cassette Transporter Subfamily A Member 1 (ABC-A1) and Type 2 Diabetes: An Association Beyond HDL Cholesterol ...
Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo. Circulation. ... The Essential Role of the ATP-Binding Cassette Transporter 1 (ABCA1) in HDL Metabolism. The essential role of ABCA1 in HDL ... ABCA1 indicates ATP-binding cassette transporter 1; HDL, high-density lipoprotein; HDL-C, high-density lipoprotein-cholesterol ... The Essential Role of the ATP-Binding Cassette Transporter 1 (ABCA1) in HDL Metabolism ...
  • In the first pedigree, a 1-bp deletion in exon 13, resulting in truncation of the predicted protein to approximately one-fourth of its normal size, co-segregated with the disease phenotype. (nih.gov)
  • Recently, we demonstrated that HIV-1, via its protein Nef, inhibits the activity of the major cellular cholesterol transporter ATP binding cassette transporter A1 (ABCA1), suggesting that the virus may use this mechanism to get access to cellular cholesterol. (aspetjournals.org)
  • The report provides comprehensive information on the ATP Binding Cassette Sub Family A Member 1 (ATP Binding Cassette Transporter 1 or ABC 1 or ATP Binding Cassette 1 or Cholesterol Efflux Regulatory Protein or ABCA1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (reportsnreports.com)
  • Additionally, the report provides an overview of key players involved in ATP Binding Cassette Sub Family A Member 1 (ATP Binding Cassette Transporter 1 or ABC 1 or ATP Binding Cassette 1 or Cholesterol Efflux Regulatory Protein or ABCA1) targeted therapeutics development and features dormant and discontinued projects. (reportsnreports.com)
  • Here we show that the solute binding protein (BlG16BP) associated with an ATP binding cassette (ABC) transporter from the probiotic Bifidobacterium animalis subsp. (lu.se)
  • We have assigned the 1 H, 15 N, 13 C backbone resonances of the second periplasmic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter of Escherichia coli / Salmonella which is important for the recognition of the maltose binding protein MalE. (springer.com)
  • Boos W, Lucht JM (1996) Periplasmic binding protein-dependant ABC transporters. (springer.com)
  • Shilton BH, Shuman HA, Mowbray SL (1996) Crystal structures and solution conformations of a dominantnegative mutant of E . coli maltose-binding protein. (springer.com)
  • Most but not all uptake systems also have an extracytoplasmic receptor, a solute binding protein. (wikipedia.org)
  • ABC transporters are considered to be with the ABC superfamily based on the sequence and organization of their ATP-binding cassette (ABC) domains, even though the integral membrane proteins may have evolved independently several times, and thus comprise different protein families. (wikipedia.org)
  • p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. (uniprot.org)
  • 2007) Asymmetry in the Structure of the ABC Transporter Binding Protein Complex BtuCD‐BtuF. (els.net)
  • The human breast cancer resistance protein is an ATP-binding cassette (ABC) multidrug transporter that affects the bioavailability of chemotherapeutic drugs and can confer drug resistance on cancer cells. (aspetjournals.org)
  • The molecular bases of protein-steroid interactions in ABC transporters are unknown. (aspetjournals.org)
  • The observation that many ABCG proteins can interact with steroids raises interesting questions about the nature of protein-steroid interactions in these transporters. (aspetjournals.org)
  • This article focuses on the main ABC transporters involved in multidrug resistance [P-gp, multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP)] expressed in tissues of toxicological relevance, such as the blood-brain barrier, cardiovascular system, liver, kidney and intestine. (mdpi.com)
  • GLT-1 immunoreactive protein was severely decreased in ALS, both in motor cortex (71% decrease compared with control) and in spinal cord. (nih.gov)
  • In approximately a quarter of the ALS motor cortex specimens, the loss of GLT-1 protein (90% decrease from control) was dramatic. (nih.gov)
  • Because there is no loss of astroglia in ALS, the dramatic abnormalities in GLT-1 could reflect a primary defect in GLT-1 protein, a secondary loss due to down regulation, or other toxic processes. (nih.gov)
  • Glycolysis-driven lipogenesis is induced by Akt signaling and depends on sterol regulatory element-binding protein (SREBP) transcription factors. (frontiersin.org)
  • Previous studies have shown that oxysterol binding protein like 2 (OSBPL2) knockdown is closely related to cholesterol metabolism. (bioportfolio.com)
  • The ATP-binding cassette transporter ABCG2 (also named breast cancer resistance protein, BCRP) functions as a drug efflux transporter and is expressed at high levels in the human small intestine. (diva-portal.org)
  • We and others have found that an ABC transporter protein called Cdr1B (here referred to as AbcG1) is required for wild-type azole resistance in A.fumigatus Here we test the genetic relationship between the TR34 L98H allele of cyp51A and an abcG1 null mutation. (aspergillus.org.uk)
  • ATP binding cassette transporter G1 (ABCG1) mediates the cholesterol transport from cells to high-density lipoprotein (HDL), but the role of apolipoprotein A-I (apoA-I), the main protein constituent of HDL, in this process is not clear. (ebscohost.com)
  • ATP-binding cassette sub-family F member 2 is a protein that in humans is encoded by the ABCF2 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (wikipedia.org)
  • These unusual uptake systems contain an ABC protein (CbiO or NikO) but lack an extracytoplasmic solute-binding protein. (asm.org)
  • The NikABCDE system of Escherichia coli belongs to the nickel/peptide/opine ABC transporter family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and -C), and two ATPases (NikD and -E) ( 43 ). (asm.org)
  • It encodes two protein isoforms (1 and 2). (allelebiotech.com)
  • This antibody only recognizes TAP2 protein isoform 1. (allelebiotech.com)
  • There are many computational methods for predicting protein interactions and functional relationships (see [ 1 - 3 ] for recent reviews). (biomedcentral.com)
  • SIMILARITY: Belongs to the binding-protein-dependent transport CC system permease family. (univ-lyon1.fr)
  • Description: The E.Coli derived recombinant protein contains the Dermatophagoides farina Der F1 full length protein (a.a. 1-320) and fused to a 6 His Tag at C-terminus, having a total Mw of 36kDa, pI 5.88. (ascn.org)
  • Wild-type (WT), TRPA1 −/− , amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic (APP/PS1 Tg) mice, the mouse model of AD, and APP/PS1 Tg/TRPA1 −/− mice were used to examine the role of TRPA1 in pathogenesis of AD. (biomedcentral.com)
  • Background: Anion exchange protein 1 (AE1), also named solute carrier family 4 member 1 (SLC4A1), is an anion transporter that mediates chloride-bicarbonate exchange in the kidney and regulates normal acidification of the urine (1,2). (cellsignal.com)
  • Human MRP1 Vesicles are insect derived purified plasma membranes with inserted MRP1 transport protein (multidrug resistance-associated protein 1, ABCC1). (thermofisher.com)
  • MECP2 (methyl-CpG binding protein 2) is in many mammals an important regulator of neuronal function and development. (wikipathways.org)
  • Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. (wikipathways.org)
  • Our findings indicate that defects in ABC1, encoding a member of the ABC transporter superfamily, are the cause of TD. (nih.gov)
  • ATP-binding cassette transporters (ABC transporters) are members of a transport system superfamily that is one of the largest and is possibly one of the oldest families with representatives in all extant phyla from prokaryotes to humans. (wikipedia.org)
  • The ATP-binding cassette (ABC) transporter superfamily is one of the largest groups of proteins and plays a non-negligible role in phase III of the detoxification process, which is highly involved in the response of insects to environmental stress (plant secondary metabolites and insecticides). (mdpi.com)
  • Dean M, Rzhetsky A and Allikmets R (2001) The human ATP‐binding cassette (ABC) transporter superfamily. (els.net)
  • Dean M and Annilo T (2005) Evolution of the ATP‐binding cassette (ABC) transporter superfamily in vertebrates. (els.net)
  • ATP-binding cassette (ABC) superfamily members have a key role as nutrient importers and exporters in bacteria. (frontiersin.org)
  • Our study has analyzed the entire complement of ABC superfamily transporters to assess whether these play a major role in drug resistance mechanisms of C. auris . (frontiersin.org)
  • The ATP-binding cassette (ABC) proteins are one of the largest superfamily of proteins found in both prokaryotes and higher eukaryotes. (frontiersin.org)
  • 2003). Metabolic re- ABC transporters belong to a large superfamily responsible for sistance and target resistance are the two major mechanisms under- the transport of specific molecules across lipid membranes, in add- lying insecticide resistance. (deepdyve.com)
  • A superfamily of large integral ATP-binding cassette membrane proteins whose expression pattern is consistent with a role in lipid (cholesterol) efflux. (bioportfolio.com)
  • We report here refining of our previous linkage of the TD gene to a 1-cM region between markers D9S271 and D9S1866 on chromosome 9q31, in which we found the gene encoding human ATP cassette-binding transporter 1 (ABC1). (nih.gov)
  • The identification of the defective Tangier disease gene as ABCA1 has contributed substantially to the understanding of its role as a key transporter of cellular cholesterol and phospholipids across cell membranes to acceptor molecules such as apolipoprotein (apo) A-I. Interestingly, ABCA1 is widely expressed throughout many animal tissues, where it may have multiple and diverse functions ( 5 ). (diabetesjournals.org)
  • 1999) Genotype/phenotype analysis of a photoreceptor‐specific ATP‐binding cassette transporter gene, ABCR, in Stargardt disease. (els.net)
  • The ABCA1 gene belongs to a group of genes called the ATP-binding cassette family, which provides instructions for making proteins that transport molecules across cell membranes. (medlineplus.gov)
  • And the R219K polymorphism at the gene of ATP -binding cassette transporter 1(ABCA1) was reported to be associated with the profiles. (bvsalud.org)
  • Recently, our laboratory and others demonstrated that mutations in the ATP-binding cassette transporter 1 (ABCA1) gene are responsible for Tangier disease, a rare genetic disorder characterized by severely diminished plasma HDL-C concentrations and a predisposition for CHD. (cdc.gov)
  • The "classical" MDR phenotype is the result from decreased cellular drug accumulation mediated by the adenosine triphosphate binding cassette (ABC)-transporter MDR1/P-glycoprotein (MDR1/P-gp, ABCB1) encoded by the human MDR1 gene. (nih.gov)
  • Transient RNAi can be attained by application of small interferring RNAs (siRNAs), whereas a stable RNAi-mediated gene-silencing can be achieved by transfection of mammalian cells with short hairpin RNA (shRNA) encoding expression cassettes localized on plasmid or viral vectors. (nih.gov)
  • P-glycoprotein (P-gp or MDR1) is a member of the ABC transporter subfamily B and encoded by the ABCB 1 gene. (thefreelibrary.com)
  • Artificial VDR constructs lacking exon 3 (Dex3-VDR), encoding part of the DNA binding domain (DBD), and exon 8 (Dex8-VDR), encoding part of the ligand binding domain (LBD), were transiently transfected into DU-145 cells and stably-integrated into Caco-2 cells to study their effect on gene expression and cell viability. (cancerindex.org)
  • The mechanism of cholesterol induction involves oxysterol-dependent activation of the LXR/RXR transcription factors, which act on a DR4 site (direct repeat nuclear receptor-binding site with a spacing of four nucleotides) in the proximal promoter of the ABCA1 gene. (jci.org)
  • In addition, we investigated the cytotoxicity of these compounds towards cell lines overexpressing other ABC transporters (BCRP, ABCB5), cell lines with a knocked out tumor suppressor gene TP53 or cell lines overexpressing a deletion-activated EGFR oncogene. (rsc.org)
  • Reporter gene assay revealed that a region within the ABCG2 promoter close to the reported HIF-1 α response element is responsible for ABCG2 upregulation. (hindawi.com)
  • The adenosine triphosphate (ATP)‐binding cassette (ABC) genes encode transporters that are expressed on the cell membrane or organelle membranes and are involved in the export of substances out of the cell or the movement of compounds inside the cell. (els.net)
  • Dean M and Allikmets R (1995) Evolution of ATP‐binding cassette transporter genes. (els.net)
  • Homologs of other ABC transporter genes, such as CDR4 , CDR6 , and SNQ2 , also displayed raised expression in a sub-set of clinical isolates. (frontiersin.org)
  • Identification of Four ATP-Binding Cassette Transporter Genes in Cnaphalocrocis medinalis and. (deepdyve.com)
  • ATP-binding cassette transporter genes also contain the signature C motif, located just up- (ABC) transporters have been identified as important detoxification stream of the Walker B site (Dean et al. (deepdyve.com)
  • A mechanism commonly observed in pathogenic yeast such as Candida albicans involves gain-of-function mutations in transcriptional regulatory proteins that induce expression of ATP-binding cassette (ABC) transporter encoding genes. (aspergillus.org.uk)
  • For functional annotation of genes, we used two comparative genomic approaches: identification of regulatory signals and analysis of the genomic positions of genes encoding candidate nickel/cobalt transporters. (asm.org)
  • The nickel/cobalt transporter genes are often colocalized with genes for nickel-dependent or coenzyme B 12 biosynthesis enzymes. (asm.org)
  • TAP2 is one of two MHC genes whose products form a transporter molecule involved in endogenous antigen processing. (allelebiotech.com)
  • Some key DEGs are potential regulators of β-pinene via detoxification metabolism (cytochrome P450, UDP-glucuronosyltransferases and short-chain dehydrogenases), ion channel/transporter activity (unc and ATP-binding cassette families), and nuclear receptor -related genes. (biomedcentral.com)
  • ABCA1 is one of a battery of LXR/RXR target genes involved in the regulation of centripetal cholesterol transport, cholesterol excretion, and fatty acid biosynthesis (Figure 1 ). (jci.org)
  • Characterization and expression profiling of ATP-binding cassette transporter genes in the diamondback moth, Plutella xylostella (L. (biomedcentral.com)
  • MDR causes the overexpression of ATP-binding cassette (ABC) transporters and mutations in tumor suppressor genes and oncogenes. (rsc.org)
  • We distinguish four groups of genes: Human genes with checked binding sites (there is a strong experimental evidence of Rel/NF-kappaB direct control, such as chromatin immunoprecipitation or promoter transactivation), putative Human genes, checked genes in orthologous species (mouse, rat , rabbit), and putative genes in orthologous species. (lifl.fr)
  • The ATPase subunits utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to energize the translocation of various substrates across membranes, either for uptake or for export of the substrate. (wikipedia.org)
  • Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are highly expressed in tumor cells, as well as in organs involved in absorption and secretion processes, mediating the ATP-dependent efflux of compounds, both endogenous substances and xenobiotics, including drugs. (mdpi.com)
  • Cells thus generate energy in the form of adenosine triphosphate (ATP). (frontiersin.org)
  • Iba1 immunohistochemistry revealed no changes of the overall density of activated microglia in the ischemic striatum of ABC transporter inhibitor treated mice, but subtle changes of microglial morphology, that is, reduced microglial cell volume by ABCB1 deactivation after 14 and 28 days and reduced microglial ramification by ABCB1, ABCC1 and combined ABCB1 and ABCC1 deactivation after 56 days. (figshare.com)
  • ATP-binding cassette transporters, ABCA1 and ABCG1, are cell surface transporters that mediate the reverse cholesterol transport (RCT), a process that delivers cholesterol from the peripheral tissue back to the liver for disposal [ 2 ]. (alliedacademies.org)
  • Mice with increased β-cell cholesterol levels were generated by conditional deletion of the ATP-binding cassette transporters, ABCA1 and ABCG1, in β-cells (β-DKO mice). (diabetesjournals.org)
  • The ATP-binding cassette transporters ABCA1 and ABCG1 regulate cell cholesterol homeostasis by exporting cellular cholesterol to extracellular acceptors ( 1 - 4 ). (diabetesjournals.org)
  • The ATP-binding cassette transporter-1 (ABCA1) mediates cholesterol efflux and genotypic variation in ABCA1 and may impact reverse cholesterol transport and influence cardiovascular disease (CVD) risk. (biomedsearch.com)
  • Home Research Outputs An atp binding cassette transporter mediates the uptake of α. (lu.se)
  • It can stimulate cholesterol and phospholipid efflux to apoA-1 [ 18 ], one of the first stages in the reverse cholesterol transport (RCT) which mediates the cholesterol catabolism from peripheral cells back to the liver. (biomedcentral.com)
  • The element facilitates steroid hormone binding and mediates modulation of ABCG2 activity. (aspetjournals.org)
  • 1 The Lipid Metabolism Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts, Boston, MA, USA. (cdc.gov)
  • Immune cell activation is associated with shifts in cellular metabolism ( 1 , 2 ). (frontiersin.org)
  • In contrast to naïve T cells, T helper (Th) cells including type 1 (Th1), type 2 (Th2) as well as type 17 (Th17) display a reprogrammed metabolic phenotype, which is characterized by increased rates of aerobic glycolysis, leading to fatty acid synthesis (FAS) and mevalonate metabolism (Figure 1 ). (frontiersin.org)
  • Sterol regulatory element-binding proteins (SREBPs) are major transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. (aspetjournals.org)
  • It is known that the ATP-binding cassette transporter A1 (ABCA1) plays a major role in cholesterol homeostasis and high density lipoprotein (HDL) metabolism. (ebscohost.com)
  • The most direct evidence for a role of cholesterol metabolism in β cell function comes from the study of the ATP-binding cassette transporter, subfamily A, member 1 (ABCA1). (jci.org)
  • ABC transporters utilize the energy of ATP binding and hydrolysis to transport various substrates across cellular membranes. (wikipedia.org)
  • The multidomain integral membrane proteins of detoxification enzymes such as glutathione S-transferases (GSTs), carboxylesterases (CarEs) and cytochrome P450 monooxygenases ABC transporters utilize the energy produced by ATP hydrolysis to (P450s) (Ranson et al. (deepdyve.com)
  • ATP-binding cassette (ABC) transporters are transmembrane proteins, which can transport a wide variety of compounds across cell membranes utilizing the energy from ATP hydrolysis. (thefreelibrary.com)
  • Correlation between half-lives and toxicity classification increased when "relative half-lives," taking into account the formation of isomeric AG-forms due to acyl migration and eliminating the effect of hydrolysis, were used instead of plain disappearance of the initial 1-O- -AG-form. (bireme.br)
  • The concerted action of CETP-mediated cholesteryl ester transfer and HL-mediated hydrolysis of triglycerides and phospholipids helps to form the smaller HDL particles that are the preferred binding partners for scavenger receptor type B1 (SR-B1), the major HDL receptor on hepatocytes. (ahajournals.org)
  • ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated ATPases. (wikipedia.org)
  • The third subgroup of ABC proteins do not function as transporters, but are rather involved in translation and DNA repair processes. (wikipedia.org)
  • Pathogens use siderophores, such as Enterobactin, to scavenge iron that is in complex with high-affinity iron-binding proteins or erythrocytes. (wikipedia.org)
  • Borst P, Evers R, Kool M and Wijnholds J (2000) A family of drug transporters: the multidrug resistance‐associated proteins. (els.net)
  • A large number of ABC proteins are multidrug transporters and function as efflux pumps. (frontiersin.org)
  • Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of proteins have a major impact on the pharmacological behavior of most of the drugs in use today. (nih.gov)
  • Membrane transport proteins belonging to the ATP-binding cassette (ABC) family of transport proteins play a central role in the defence of organisms against toxic compounds, including anticancer drugs. (tudelft.nl)
  • ABCG proteins are composed of an N-terminal nucleotide-binding domain followed by a membrane domain with six putative transmembrane helices (TMHs). (aspetjournals.org)
  • Contributions of both ATP-binding cassette transporter and Cyp51A proteins are essential for azole resistance in Aspergillus fumigatus. (aspergillus.org.uk)
  • The vitamin transporters have an unprecedented modular architecture consisting of a single multipurpose energizing module (the Energy Coupling Factor, ECF) and multiple exchangeable membrane proteins responsible for substrate recognition (S-components). (europa.eu)
  • Major role of integral membrane proteins, carriers, or transporters in drug transport is highlighted. (hindawi.com)
  • ABCG2, also termed BCRP / MXR / ABCP, is a half ATP-binding cassette (ABC) transporter expressed on plasma membranes. (eurekaselect.com)
  • ABCG2 consists of a nucleotide-binding domain (NBD) at the amino terminus and a transmembrane domain (TMD) at the carboxyl terminus and it is postulated to form a homodimer to perform its biological functions. (eurekaselect.com)
  • The involvement hydrolyze ATP, as well as two transmembrane domains (TMDs), of ABC transporters in xenobiotic resistance for arthropods was his- which are involved in the translocation of their respective substrates torically not well documented, but an increasing number of studies (Rees et al. (deepdyve.com)
  • In this study, we investigated the effect on HIV infection of a synthetic liver X receptor (LXR) ligand, N -(2,2,2-trifluoro-ethyl)- N -[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-benzenesulfonamide (TO-901317), which is a potent stimulator of ABCA1 expression. (aspetjournals.org)
  • This anti-HIV activity was dependent on ABCA1, because the effect of the drug was significantly reduced in ABCA1-defective T cells from a patient with Tangier disease, and RNA interference-mediated inhibition of ABCA1 expression eliminated the effect of TO-901317 on HIV-1 replication. (aspetjournals.org)
  • Quantitative real-time PCR confirmed the expression of all 20 TMD transporters, underlining their potential in contributing to the C. auris drug-resistant phenotype. (frontiersin.org)
  • Methods and Results: In 3T3L-1 adipocytes, apoAI, HDL, and methyl-β-cyclodextrin inhibited chemotactic factor expression. (elsevier.com)
  • Key words: Cnaphalocrocis medinalis, ABC transporter, mRNA expression, insecticide detoxification The rice leaffolder, Cnaphalocrocis medinalis (Lepidoptera: enzymes in Plutella xylostella, in addition to GSTs, CarEs and Pyralidae) is a major pest of rice crops, and is widely distributed in P450s (He et al. (deepdyve.com)
  • aromadendrene,13-sitosterol-0-glucoside, and 13-carotene), and alkaloids (glaucine, harmine, and sanguinarine) were evaluated as potential P-gp inhibitors (transporter activity and expression level) in P-gp expressing Caco-2 and CEM/ADR5000 cancer cell lines. (thefreelibrary.com)
  • 1 Department of Medical Genetics and 2 Department of Pathology and Laboratory Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. (jci.org)
  • Here, we identify a steroid-binding element in the membrane domain of ABCG2 with a similarity to steroid hormone/nuclear receptors. (aspetjournals.org)
  • In this article, we describe the identification of a functional steroid-binding element in ABCG2 R482G . (aspetjournals.org)
  • ABCG2 is an efflux transporter commonly found to overexpress in multidrug resistant (MDR) cancer cells. (hindawi.com)
  • It is usually associated with an increased efflux of cytotoxic drugs by ATP-binding cassette (ABC) transporters including ABCG2. (hindawi.com)
  • Overexpression of ABCG2 in cancer cell lines in vitro has been shown to confer MDR to a variety of anticancer drugs including mitoxantrone, irinotecan, methotrexate, flavopiridol, and anthracyclines [ 1 ]. (hindawi.com)
  • We aim to provide an overview of properties of the mammalian ABC transporters known to mediate significant transport of clinically relevant drugs. (nih.gov)
  • Bioassays were conducted using mosquito populations that were either susceptible or resistant to temephos by exposure to insecticide alone or in combination with sublethal doses of the ABC transporter inhibitor, verapamil (30, 35 and 40 μM). (scielo.br)
  • Prepared from Sf9 cells which have been engineered to over-express specific ABC transporters, these "inside-out" vesicles provide high levels of transporter activity with low background, giving you a clear signal if your compound is a substrate or inhibitor of a specific efflux transporter. (thermofisher.com)
  • ABC transporters are also involved in multiple drug resistance, and this is how some of them were first identified. (wikipedia.org)
  • Gottesman MM, Fojo T and Bates SE (2002) Multidrug resistance in cancer: role of ATP‐dependent transporters. (els.net)
  • Kolaczkowski M and Goffeau A (1997) Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance. (els.net)
  • The best result in the series was obtained with the addition of verapamil (40 μM), which led to a 2x increase in the toxicity of temephos, suggesting that ABC transporters may be partially involved in conferring resistance to the populations evaluated. (scielo.br)
  • The capacity of ABC transporters to efflux a broad spectrum of xenobiotics represents one of the major mechanisms of clinical multidrug resistance in pathogenic fungi including Candida species. (frontiersin.org)
  • Together, our analysis supports the involvement of these transporters in multidrug resistance in C. auris . (frontiersin.org)
  • Inhibitors of these transporters are thus potentially useful tools to reverse this transporter-mediated cellular resistance to anticancer drugs and, eventually, to enhance the effectiveness of the treatment of patients with drug-resistant cancer. (tudelft.nl)
  • ABC transporters also play an important role in the detoxi- sults in disturbance of the environment and resistance of pests to fication of insecticides. (deepdyve.com)
  • ATP binding cassette transporters and drug resistance in breast cancer. (semanticscholar.org)
  • MRP3 is involved in multi-drug resistance (1). (cellsignal.com)
  • 이 문서는 2019년 1월 21일 (월) 16:49에 마지막으로 편집되었습니다. (wikipedia.org)
  • ATP-binding cassette transporter A1 (ABCA1) has been found to mediate the transfer of cellular cholesterol across the plasma membrane to apolipoprotein A‑I (apoA‑I), and is essential for the synthesis of high‑density lipoprotein. (spandidos-publications.com)
  • While ABC transporters typically mediate the export of substrates out of cells, transporters expressed on these inside-out vesicles import substrates into the vesicles. (thermofisher.com)
  • It always involves more than one amino acid and includes all residues involved in nucleotide-binding. (uniprot.org)
  • ABC transporters have a modular structure, consist- searching the transcriptome dataset, which may be involved in the ing of two nucleotide-binding domains (NBDs), which bind and insecticide detoxification displayed by these moths. (deepdyve.com)
  • Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains. (ebi.ac.uk)
  • In addition, roles of various receptors, ATP powered pumps, channels, and transporters in transport of vital molecules in maintenance of homeostasis and normal body functions have been described in detail. (hindawi.com)
  • EGFR can be activated with ErbB receptors, either via autocrine or paracrine ligand binding. (spandidos-publications.com)
  • This preference is also reflected in the α-(1,6)-galactoside uptake profile of the bacterium. (lu.se)
  • By comparison, B. ovatus mono-cultures grew very efficiently on this trisaccharide These findings suggest that the ABC-mediated uptake of raffinose provides an important competitive advantage, particularly against dominant Bacteroides that lack glycan-specific ABC-transporters. (lu.se)
  • The nickel-responsive repressor NikR regulates many nickel uptake systems, though the NikR-binding signal is divergent in various taxonomic groups of bacteria and archaea. (asm.org)
  • Though distantly related ABC transporter systems from pathogenic Yersinia pseudotuberculosis and Brucella suis are also implicated in the high-affinity nickel uptake ( 33 , 49 ), many other representatives of this ABC transporter family are involved in uptake of other compounds, i.e., dipeptides and oligopeptides ( 1 , 37 ). (asm.org)
  • The accumulation of cholesterol in macrophage foam cells results from the uptake of retained and modified apoB lipoproteins ( 1 ) and is a central event in atherogenesis. (jci.org)
  • Recently an important role for ABCA1, a cellular cholesterol transporter, has emerged in regulating cholesterol homeostasis and insulin secretion in pancreatic β cells. (jci.org)
  • Apolipoprotein A-I but not high-density lipoproteins are internalised by RAW macrophages: roles of ATP-binding cassette transporter A1 and scavenger receptor BI. (ebscohost.com)
  • The major types of the plasma lipoproteins and their apolipoprotein components and physiologic functions are briefly presented in Table 1 . (asnjournals.org)
  • The aim of the proposal is threefold: First, we will address the question how properties of primary and secondary transporters are combined in ECF transporters to obtain a novel transport mechanism. (europa.eu)
  • Besides, it is involved in the process of reverse cholesterol transport (RCT) to regulate cholesterol homeostasis [ 1 ]. (alliedacademies.org)
  • Genotypic variation in ATP-binding cassette transporter-1 (ABCA1) as contributors to the high and low high-density lipoprotein-cholesterol (HDL-C) phenotype. (biomedsearch.com)
  • In the endogenous pathway ( Figure 1 ), the liver assembles and secretes triglyceride-rich very low-density lipoprotein (VLDL) particles, which transport triglycerides from the liver to peripheral tissues. (asnjournals.org)
  • High-density lipoprotein (HDL) plays an important role in reverse cholesterol transport, which shuttles cholesterol from peripheral cells to the liver ( 16 ), an important step that relieves the peripheral cells from cholesterol burden ( Figure 1 ). (asnjournals.org)
  • This Perspective will focus on recent studies on the regulation and role of ABCA1 in cellular cholesterol efflux, lipoprotein physiology, and atherogenesis, attempting to place this work in the broader context of studies on cellular cholesterol efflux, centripetal cholesterol transport, and ABC transporter structure and function. (jci.org)
  • 2020. "Transcriptional Response of ATP-Binding Cassette (ABC) Transporters to Insecticide in the Brown Planthopper, Nilaparvata lugens (Stål). (mdpi.com)
  • Frontiers in Plant Science , Vol. 11, p. 1-7 (2020). (uclouvain.be)
  • Journal of the American Society of Brewing Chemists , Vol. 1, no.11, p. 1-11 (2020). (uclouvain.be)
  • Many other xenotoxins, (pre-)carcinogens and endogenous compounds are also influenced by the ABC transporters, with corresponding consequences for the well-being of the individual. (nih.gov)
  • ATP-binding cassette (ABC) transporters prevent the access of pharmacological compounds to the ischemic brain, thereby impeding the efficacy of stroke therapies. (figshare.com)
  • Using activity guided purification, four known compounds, sesquiterpene atractylenolide III (1), and the polyacetylenes 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol (2), 14-acetox. (bioportfolio.com)
  • Microbiological screens will be developed to search for compounds that inhibit prokaryote-specific steps of the mechanism of ECF transporters. (europa.eu)
  • From 2,600 compounds, a xanthone compound (IMB 2026791) was selected using this HTS assay, and it was proved as an apoA-I binding agonist to ABCA1 by a flow cytometry assay and western blot analysis. (ebscohost.com)
  • The structures of the new compounds were determined by spectral (FT-IR, (1)H NMR) methods. (bireme.br)
  • Using in silico molecular docking, we calculated the binding energies and simulated the interactions of these compounds with the corresponding amino acid residues at the binding site of P-gp. (rsc.org)
  • Pharmacological properties affected by ABC transporters include the oral bioavailability, hepatobiliary, direct intestinal, and urinary excretion of drugs and drug-metabolites and -conjugates. (nih.gov)
  • Moreover, the penetration of drugs into a range of important pharmacological sanctuaries, such as brain, testis, and fetus, and the penetration into specific cell- and tissue compartments can be extensively limited by ABC transporters. (nih.gov)
  • Pharmacological inhibition of PP2B activity diminished the fibrilized Aβ 1-42 -induced production of pro-inflammatory cytokines, activation of NF-κB and NFAT and astrogliosis in astrocytes. (biomedcentral.com)
  • This cell surface transporter facilitates the efflux of phospholipids and cholesterol onto lipid-poor apolipoproteins, initiating the formation of HDL particles. (jci.org)
  • The eukaryotic ABC transporters are promiscuous exporters and can extrude a variety of substrates including metals, drugs, xenobiotics, lipids, and other cellular metabolites ( Prasad and Goffeau, 2012 ). (frontiersin.org)
  • ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1. (nih.gov)
  • Experiments using specific COX and LOX (lipoxygenase) inhibitors demonstrated the importance of COX-1 activity for acute (20 min) stimulation of insulin secretion, suggesting that AA metabolites may be responsible for the insulinotropic effects. (portlandpress.com)
  • Most cases of T2DM are also characterized by elevated circulating fatty acid concentrations due to high dietary lipid intake, which is associated with decreased GSIS (glucose-stimulated insulin secretion) [ 1 , 2 ]. (portlandpress.com)
  • Non-digestible dietary galacto- and gluco-α-(1,6)-oligosaccharides from legumes and starch, respectively, are preferentially fermented by mainly bifidobacteria and lactobacilli in the human gut. (lu.se)
  • The [³H] cholesterol efflux assay of IMB2026791 treated ABCA1-CHO cells and PMA induced THP-1 macrophages (human acute monocytic leukemia cell) further confirmed the compound as an accelerator of cholesterol efflux in a dose-dependent manner with an EC50 of 25.23 μM. (ebscohost.com)
  • DNA complexes with human apurinic/apyrimidinic endonuclease 1: structural insights revealed by pulsed dipolar EPR with orthogonal spin labeling. (nih.gov)
  • Cathepsin L activated by mutant p53 and Egr-1 promotes ionizing radiation-induced EMT in human NSCLC. (abcam.com)
  • Human MRP1 Vesicles are part of a larger group of transporter vesicles known as ABC transporter vesicles. (thermofisher.com)
  • Microbial metabolic functions related to energy harvest, including glycan degradation, phosphotransferase systems and ABC transporters, were enriched in the ob/ob mice. (springer.com)
  • They have been associated with many diseases in humans, including obesity [ 1 ], type 2 diabetes [ 2 , 3 ] and other metabolic diseases. (springer.com)
  • The membrane-spanning region of the ABC transporter protects hydrophilic substrates from the lipids of the membrane bilayer thus providing a pathway across the cell membrane. (wikipedia.org)
  • In the exogenous pathway ( Figure 1 ), chylomicrons transport dietary lipids that are absorbed from the intestine via the systemic circulation. (asnjournals.org)
  • ABC transporters can be deactivated by selective inhibitors, which potently increase the brain accumulation of drugs. (figshare.com)
  • 1 HDL plays a key role in reverse cholesterol transport by promoting cholesterol efflux from peripheral cells, including cholesterol-laden macrophages, and delivering acquired cholesterol to liver for excretion, a process that is believed to be atheroprotective. (ahajournals.org)
  • Silencing ATP-binding cassette A-1 abrogated the effect of apoAI, but not HDL, whereas silencing ATP-binding cassette G-1 or scavenger receptor B-1 abrogated the effect of HDL but not apoAI. (elsevier.com)
  • These effects are consistent with disruption and removal of cholesterol from LRs, which are regulated by cholesterol transporters, such as ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1. (elsevier.com)
  • Transient receptor potential ankyrin 1 (TRPA1) channel plays an important role in pain and inflammation. (biomedcentral.com)