Parasitic Sensitivity Tests
A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Infections of the BRAIN caused by the protozoan TOXOPLASMA gondii that primarily arise in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES (see also AIDS-RELATED OPPORTUNISTIC INFECTIONS). The infection may involve the brain diffusely or form discrete abscesses. Clinical manifestations include SEIZURES, altered mentation, headache, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. (From Joynt, Clinical Neurology, 1998, Ch27, pp41-3)
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Electron Transport Complex III
A multisubunit enzyme complex that contains CYTOCHROME B GROUP; CYTOCHROME C1; and iron-sulfur centers. It catalyzes the oxidation of ubiquinol to UBIQUINONE, and transfers the electrons to CYTOCHROME C. In MITOCHONDRIA the redox reaction is coupled to the transport of PROTONS across the inner mitochondrial membrane.
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
An electrochemical technique for measuring the current that flows in solution as a function of an applied voltage. The observed polarographic wave, resulting from the electrochemical response, depends on the way voltage is applied (linear sweep or differential pulse) and the type of electrode used. Usually a mercury drop electrode is used.
A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
Investigational New Drug Application
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
United States Food and Drug Administration
A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
Prenatal protozoal infection with TOXOPLASMA gondii which is associated with injury to the developing fetal nervous system. The severity of this condition is related to the stage of pregnancy during which the infection occurs; first trimester infections are associated with a greater degree of neurologic dysfunction. Clinical features include HYDROCEPHALUS; MICROCEPHALY; deafness; cerebral calcifications; SEIZURES; and psychomotor retardation. Signs of a systemic infection may also be present at birth, including fever, rash, and hepatosplenomegaly. (From Adams et al., Principles of Neurology, 6th ed, p735)
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Alternative oxidase inhibitors potentiate the activity of atovaquone against Plasmodium falciparum. (1/172)Recent evidence suggests that the malaria parasite Plasmodium falciparum utilizes a branched respiratory pathway including both a cytochrome chain and an alternative oxidase. This branched respiratory pathway model has been used as a basis for examining the mechanism of action of two antimalarial agents, atovaquone and proguanil. In polarographic assays, atovaquone immediately reduced the parasite oxygen consumption rate in a concentration-dependent manner. This is consistent with its previously described role as an inhibitor of the cytochrome bc1 complex. Atovaquone maximally inhibited the rate of P. falciparum oxygen consumption by 73% +/- 10%. At all atovaquone concentrations tested, the addition of the alternative oxidase inhibitor, salicylhydroxamic acid, resulted in a further decrease in the rate of parasite oxygen consumption. At the highest concentrations of atovaquone tested, the activities of salicylhydroxamic acid and atovaquone appear to overlap, suggesting that at these concentrations, atovaquone partially inhibits the alternative oxidase as well as the cytochrome chain. Drug interaction studies with atovaquone and salicylhydroxamic acid indicate atovaquone's activity against P. falciparum in vitro is potentiated by this alternative oxidase inhibitor, with a sum fractional inhibitory concentration of 0.6. Propyl gallate, another alternative oxidase inhibitor, also potentiated atovaquone's activity, with a sum fractional inhibitory concentration of 0.7. Proguanil, which potentiates atovaquone activity in vitro and in vivo, had a small effect on parasite oxygen consumption in polarographic assays when used alone or in the presence of atovaquone or salicylhydroxamic acid. This suggests that proguanil does not potentiate atovaquone by direct inhibition of either branch of the parasite respiratory chain. (+info)
Atovaquone-proguanil compared with chloroquine and chloroquine-sulfadoxine-pyrimethamine for treatment of acute Plasmodium falciparum malaria in the Philippines. (2/172)This randomized, open-label clinical trial compared a fixed-dose combination of atovaquone and proguanil (n=55) with chloroquine (n=23) or a combination of chloroquine, sulfadoxine, and pyrimethamine (n=32) for treatment of acute falciparum malaria in the Philippines. Patients were hospitalized for 28 days to ensure medication compliance and prevent reinfection. Atovaquone-proguanil produced a significantly higher cure rate (100%) compared with that for chloroquine (30.4%; P<.0001) or chloroquine-sulfadoxine-pyrimethamine (87.5%; P<.05). Treatments did not differ significantly with respect to parasite clearance time (mean: 46.7 h for atovaquone-proguanil, 60.0 h for chloroquine, and 42.8 h for chloroquine-sulfadoxine-pyrimethamine) or fever clearance time (mean, 38.8, 46.8, and 34.5 h, respectively). Adverse events were typical of malaria symptoms; the most frequently reported events were vomiting (18% for atovaquone-proguanil, 17% for chloroquine, and 9% for chloroquine-sulfadoxine-pyrimethamine), abdominal pain (15%, 17%, and 3%, respectively), anorexia (11%, 13%, and 0%, respectively), and headache (6%, 17%, and 3%, respectively). Atovaquone-proguanil was well tolerated and more effective than chloroquine or chloroquine-sulfadoxine-pyrimethamine for treatment of multidrug-resistant falciparum malaria in the Philippines. (+info)
Prophylactic activity of atovaquone against Plasmodium falciparum in humans. (3/172)The prophylactic antimalarial activity of atovaquone was determined in a randomized, double-blind, placebo-controlled study of healthy volunteers who were challenged by the bite of Plasmodium falciparum-infected Anopheles stephensi. Subjects were randomly assigned to one of three groups: six received seven daily doses of 750 mg of atovaquone, starting the day before challenge; six received a single dose of 250 mg of atovaquone the day before challenge; and four received placebo. Polymerase chain reaction- and culture-confirmed parasitemia developed in all four placebo recipients, but in none of the drug recipients, indicating that either of the atovaquone regimens provides effective prophylaxis (P = 0.005). However, in low-dose recipients, the drug levels by day 6.5 were profoundly subtherapeutic, indicating that parasites were eliminated prior to the establishment of erythrocytic infection. Atovaquone thus protects non-immune subjects against mosquito-transmitted falciparum malaria, and has causal prophylactic activity. (+info)
A randomized, double-blind, placebo-controlled field trial to determine the efficacy and safety of Malarone (atovaquone/proguanil) for the prophylaxis of malaria in Zambia. (4/172)Malaria poses a major health risk to people who are exposed to infection in malaria-endemic areas. A randomized, double-blind, placebo-controlled study was conducted to determine the efficacy and safety of Malarone (250 mg of atovaquone/100 mg of proguanil hydrochloride per tablet) for the chemoprophylaxis of Plasmodium falciparum malaria in Zambia. Adult volunteers received a three-day treatment course of Malarone to eliminate pre-existing parasitemia and were then immediately randomized to treatment with either one Malarone tablet daily (n = 136), or one placebo tablet daily (n = 138) for at least 10 weeks. Malaria blood smears were prepared on a weekly basis and a failure of chemoprophylaxis was defined as any subject who had a positive blood smear, or who withdrew from the study due to a treatment-related adverse event. The prophylaxis success rates in the Malarone and placebo groups were 98% and 63%, respectively (P < 0.001). The most commonly reported adverse events with at least a possible causal relationship to study medication were headache and abdominal pain, which occurred with a higher incidence in the placebo group. No subjects were withdrawn from the study due to a treatment-related adverse event. Thus, Malarone appears to have an excellent safety and efficacy profile for the chemoprophylaxis of P. falciparum infection. (+info)
Efficacy and safety of atovaquone/proguanil compared with mefloquine for treatment of acute Plasmodium falciparum malaria in Thailand. (5/172)The increasing frequency of therapeutic failures in falciparum malaria underscores the need for novel, rapidly effective antimalarial drugs or drug combinations. Atovaquone and proguanil are blood schizonticides that demonstrate synergistic activity against multi-drug-resistant Plasmodium falciparum in vitro. In an open-label, randomized, controlled clinical trial conducted in Thailand, adult patients with acute P. falciparum malaria were randomly assigned to treatment with atovaquone and proguanil/hydrochloride (1,000 mg and 400 mg, respectively, administered orally at 24-hr intervals for three doses) or mefloquine (750 mg administered orally, followed 6 hr later by an additional 500-mg dose). Efficacy was assessed by cure rate (the percentage of patients in whom parasitemia was eliminated and did not recur during 28 days of follow-up), parasite clearance time (PCT), and fever clearance time (FCT). Safety was assessed by sequential clinical and laboratory assessments for 28 days. Atovaquone/proguanil was significantly more effective than mefloquine (cure rate 100% [79 of 79] vs. 86% [68 of 79]; P < 0.002). The atovaquone/proguanil and mefloquine treatments did not differ with respect to PCT (mean = 65 hr versus 74 hr) or FCT (mean = 59 hr versus 51 hr). Adverse events were generally typical of malaria symptoms and each occurred in < 10% of the patients in either group, with the exception of increased vomiting found in the atovaquone/proguanil group. Transient elevations of liver enzyme levels occurred more frequently in patients treated with atovaquone/proguanil than with mefloquine, but the differences were not significant and values returned to normal by day 28 in most patients. The combination of atovaquone and proguanil was well tolerated and more effective than mefloquine in the treatment of acute uncomplicated multidrug-resistant falciparum malaria in Thailand. (+info)
Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group. (6/172)The continuing spread of drug-resistant malaria emphasizes the need for new antimalarial drugs. Atovaquone is a broad-spectrum antiprotozoal drug with a novel mechanism of action, via inhibition of parasite mitochondrial electron transport, and a favorable safety profile. Early studies with atovaquone alone for treatment of malaria demonstrated good initial control of parasitemia but an unacceptable rate of recrudescent parasitemia. Parasites isolated during recrudescence after treatment with atovaquone alone were resistant to atovaquone in vitro. The combination of atovaquone and proguanil is synergistic in vitro, and clinical studies demonstrated enhanced efficacy of the combination compared to either drug alone for treatment of malaria. Malarone, a fixed-dose combination of 250 mg of atovaquone and 100 mg of proguanil hydrochloride, is available in many countries for treatment of acute, uncomplicated malaria caused by Plasmodium falciparum. At the recommended dose (in adults, four tablets once a day for three days), the overall cure rate was > 98% in more than 500 patients with falciparum malaria. In four randomized, controlled clinical trials, treatment with atovaquone and proguanil hydrochloride was significantly more effective than mefloquine (Thailand), amodiaquine (Gabon), chloroquine (Peru and the Philippines) or chloroquine plus pyrimethamine/sulfadoxine (Philippines). In clinical trials where the comparator drug was highly effective, treatment with atovaquone and proguanil hydrochloride was equally effective. Parasites isolated during recrudescence after treatment with the combination of atovaquone and proguanil were not resistant to atovaquone in vitro. The most commonly reported adverse events in clinical trials (abdominal pain, anorexia, nausea, vomiting, diarrhea and coughing) occurred with similar frequency in patients treated with a comparator drug. Malarone is a safe and effective new agent for treatment of malaria. (+info)
A mechanism for the synergistic antimalarial action of atovaquone and proguanil. (7/172)A combination of atovaquone and proguanil has been found to be quite effective in treating malaria, with little evidence of the emergence of resistance when atovaquone was used as a single agent. We have examined possible mechanisms for the synergy between these two drugs. While proguanil by itself had no effect on electron transport or mitochondrial membrane potential (DeltaPsim), it significantly enhanced the ability of atovaquone to collapse DeltaPsim when used in combination. This enhancement was observed at pharmacologically achievable doses. Proguanil acted as a biguanide rather than as its metabolite cycloguanil (a parasite dihydrofolate reductase [DHFR] inhibitor) to enhance the atovaquone effect; another DHFR inhibitor, pyrimethamine, also had no enhancing effect. Proguanil-mediated enhancement was specific for atovaquone, since the effects of other mitochondrial electron transport inhibitors, such as myxothiazole and antimycin, were not altered by inclusion of proguanil. Surprisingly, proguanil did not enhance the ability of atovaquone to inhibit mitochondrial electron transport in malaria parasites. These results suggest that proguanil in its prodrug form acts in synergy with atovaquone by lowering the effective concentration at which atovaquone collapses DeltaPsim in malaria parasites. This could explain the paradoxical success of the atovaquone-proguanil combination even in regions where proguanil alone is ineffective due to resistance. The results also suggest that the atovaquone-proguanil combination may act as a site-specific uncoupler of parasite mitochondria in a selective manner. (+info)
Pharmacokinetics of azithromycin administered alone and with atovaquone in human immunodeficiency virus-infected children. The ACTG 254 Team. (8/172)To evaluate if atovaquone (ATQ) interacts pharmacokinetically with azithromycin (AZ) in human immunodeficiency virus-infected children, 10 subjects (ages, 4 to 13 years) were randomized in a crossover study to receive AZ (5 mg/kg/day) alone (ALONE) or AZ (5 mg/kg/day) and ATQ (30 mg/kg/day) simultaneously (SIM) prior to receiving AZ and ATQ staggered by 12 h. Despite a lack of significant difference in the mean AZ pharmacokinetic parameters, the steady-state values of AZ's area under the concentration-time curve from 0 to 24 h and maximum concentration in serum were consistently lower (n = 7 of 7) for the SIM regimen than they were for the ALONE regimen. A larger study will be required to determine if ATQ affects AZ pharmacokinetics and efficacy in a clinically significant manner. (+info)
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Drug Interaction Study Between Atovaquone and Antiretroviral Agents in HIV-1 Infected Patients - Full Text View -...
Malarone® (atovaquone/proguanil) is frequently used in malaria prophylaxis. Unfortunately, there are indications that certain anti-HIV agents may decrease atovaquone plasma levels by induction of atovaquone metabolism.. For travelling HIV patients, the clinical consequences of these possible drug drug interactions are serious, since a diminished exposure to the anti-malarial drug will result in suboptimal prophylaxis of malaria and potential development of drug resistant strains of Plasmodium falciparum.. The purpose of this study is to find out if HIV patients using HAART regimes with either lopinavir/ritonavir, atazanavir/ritonavir or efavirenz have lower atovaquone plasma levels than healthy volunteers after a single dose of atovaquone/proguanil. ...
Antimalarial pharmacology and therapeutics of atovaquone. - LSTM Online Archive
Atovaquone is used as a fixed-dose combination with proguanil (Malarone) for treating children and adults with uncomplicated malaria or as chemoprophylaxis for preventing malaria in travellers. Indeed, in the USA, between 2009 and 2011, Malarone prescriptions accounted for 70% of all antimalarial pre-travel prescriptions. In 2013 the patent for Malarone will expire, potentially resulting in a wave of low-cost generics. Furthermore, the malaria scientific community has a number of antimalarial quinolones with a related pharmacophore to atovaquone at various stages of pre-clinical development. With this in mind, it is timely here to review the current knowledge of atovaquone, with the purpose of aiding the decision making of clinicians and drug developers involved in the future use of atovaquone generics or atovaquone derivatives.. ...
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia. - Department of Oncology
Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that reduce hypoxia in tumours, we conduct a high-throughput screen for oxygen consumption rate (OCR) reduction and identify a number of drugs with this property. For this study we focus on the anti-malarial, atovaquone. Atovaquone rapidly decreases the OCR by more than 80% in a wide range of cancer cell lines at pharmacological concentrations. In addition, atovaquone eradicates hypoxia in FaDu, HCT116 and H1299 spheroids. Similarly, it reduces hypoxia in FaDu and HCT116 xenografts in nude mice, and causes a significant tumour growth delay when combined with radiation. Atovaquone is a ubiquinone analogue, and decreases the OCR by inhibiting mitochondrial complex III. We are now undertaking clinical studies to assess whether atovaquone reduces tumour hypoxia in patients, thereby increasing the efficacy of radiotherapy.
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To evaluate if atovaquone (ATQ) interacts pharmacokinetically with azithromycin (AZ) in | Selective Inhibitors of Protein...
To evaluate if atovaquone (ATQ) interacts pharmacokinetically with azithromycin (AZ) in human being immunodeficiency virus-infected children, 10 subjects (ages, 4 to 13 years) were randomized inside a crossover study to receive AZ (5 mg/kg/day time) only (ALONE) or AZ (5 mg/kg/day time) and ATQ (30 mg/kg/day time) simultaneously (SIM) prior to receiving AZ and ATQ staggered by 12 h. larger study will be required to determine if ATQ affects AZ pharmacokinetics and effectiveness inside a clinically significant manner. Children infected with human being immunodeficiency computer virus (HIV) have an increased risk of severe and recurrent infections (3, 15, 16, 18, 20), among which the most common is definitely pneumonia (PCP). A new, promising combination, azithromycin (AZ) plus atovaquone (ATQ), is currently under investigation inside a phase II/III medical trial (ACTG 254) to compare its efficiency and protection with those of trimethoprim-sulfamethoxazole in the prophylaxis of multiple ...
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Atovaquone - Dog
Atovaquone (hydroxy-1,4-naphthoquinone) is a naphthoquinone analog. This drug has poor water solubility and is usually incorporated into lipid-based formulations and requires to be given with a fatty meal for adequate absorption. Atovaquone is indicated for use against canine infections caused by Toxoplasma spp, Babesia spp, Pneumocystis spp. With Babesia spp infections, it is sometimes used in combination with azithromycin. Recommended dose rate is 10 - 15 mg/kg with fatty meal given orally every 8 hours for 10 - 21 days. ...
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DMOZ - Health: Pharmacy: Drugs and Medications: A: Atovaquone
Information for health care professionals and patients on malaria, its treatment, and prophylaxis using Malarone (atovaquone proguanil HCI) tablets from GlaxoSmithKline. ...
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Atovaquone and Proguanil is a very strong oral medication marketed under the brand name Malarone that is intended for the treatment of malaria.
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Atovaquone and proguanil are medications to treat malaria, a disease caused by parasites. These medicines work by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as...
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What is in this leaflet?Unless explained differently, the information for Malarone in this leaflet applies to both Malarone Tablets (250/100) and Malarone Junior Tablets (62.5/25) (refer to the Product description section near the end of the leaflet for a description of these two products).Please read this leaflet carefully before you take Malarone.This leaflet answers some common questions about Malarone. It does not contain all of the available information.It does not take the place of talking..
Comparison of Atovaquone and Azithromycin with Trimethoprim-Sulfamethoxazole for the Prevention of Serious Bacterial Infections...
Background. Trimethoprim-sulfamethoxazole (TMP-SMZ) has been used extensively for the prevention of Pneumocystis carinii (also referred to as Pneumocystis jiroveci) pneumonia (PCP) and other opportunistic infections in human immunodeficiency virus (HIV)-infected children. Because the efficacy of TMP-SMZ for treatment of bacterial infections is limited, it is sometimes poorly tolerated, and there is risk of emergence of drug-resistant strains associated with widespread use, we evaluated a regimen that included atovaquone and azithromycin.. Methods. A randomized, double-blind, placebo-controlled trial was designed to determine whether atovaquone-azithromycin had equivalent efficacy to TMP-SMZ for the prevention of serious bacterial infections and to compare the long-term tolerance, PCP breakthrough rates, and nonserious bacterial infection rates among HIV-infected children aged 3 months to 19 years. Children qualified for PCP prophylaxis (on the basis of Centers for Disease Control and ...
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Malarone and Breastfeeding
No studies have been done on breastfeeding and Malarone (atovaquone/proguanil). However, as this eMedTV page explains, the drug is not likely to pass through breast milk in high amounts. This article offers more details on using Malarone while nursing.
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A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive Children - Full Text View -...
Although SMX/TMP remains the drug of choice for PCP prophylaxis, drug sensitivity may limit its use. Atovaquone has demonstrated greater safety than SMX/TMP and thus is suitable as a candidate drug for treatment and prophylaxis of PCP. Azithromycin, with a broad anti-microbial spectrum (including mycoplasma and atypical mycoplasma), is an attractive prophylactic agent for use in children with HIV infection, due to its relative safety and once-daily dosing regimen. Therefore, the combination of atovaquone and azithromycin may offer broader antimicrobial coverage and greater safety than SMX/TMP.. Patients are randomized to receive either SMX/TMP or combination micronized atovaquone/azithromycin. Crossover to the alternative regimen may occur if serious toxicity is observed. Patients are monitored for occurrence of serious bacterial infections or PCP breakthrough, and when a serious bacterial infection occurs, patients are crossed over to the alternative regimen. Treatment continues until 2 years ...
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Assess pulmonary function by measuring lung volumes, breath sounds, respiratory rate, and other symptoms (cough, dyspnea, shortness of breath) (See Appendices I, J, K). Report changes in pulmonary function to help document the effects of drug therapy in treating PCP infections. ...
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Avoid concomitant other efavirenz-containing products (eg, Atripla unless needed for dose adjustment with rifampin), atazanavir (treatment-experienced), posaconazole, boceprevir, simeprevir, atovaquone/proguanil, pibrentasvir/glecaprevir, velpatasvir/sofosbuvir/voxilaprevir, alcohol, psychoactive, other NNRTIs or hepatotoxic drugs. Caution with drugs metabolized by, or that affect activity of, CYP2B6 or CYP3A4. Efavirenz levels decreased by carbamazepine, phenytoin, phenobarbital, rifampin (adjust dose). May decrease levels of indinavir, amprenavir, atazanavir, saquinavir, anticonvulsants, clarithromycin, calcium channel blockers (eg, diltiazem, felodipine, nicardipine, nifedipine, verapamil), itraconazole, ketoconazole, lopinavir (adjust dose: see full labeling), maraviroc, bupropion, methadone, rifabutin (increase dose; see full labeling), sertraline, simvastatin, atorvastatin, pravastatin, hormonal contraceptives (eg, norgestimate, etonogestrel), immunosuppressants (eg, cyclosporine, ...
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Results - Find My Clinical Trial
Multicenter Therapeutic Efficacy Assessment of Pyronaridine-Artesunate (Pyramax®) and New Drug Combinations With Atovaquone-Proguanil for the Treatment of Uncomplicated P. Falciparum Malaria in Cambodia ...
DailyMed - ATOVAQUONE AND PROGUANIL HYDROCHLORIDE- atovaquone and proguanil hydrochloride tablet, film coated
In seven controlled trials, 436 adolescents and adults received atovaquone and proguanil hydrochloride for treatment of acute, uncomplicated P. falciparum malaria. The range of mean ages of subjects was 26 to 29 years; 79% of subjects were male. In these studies, 48% of subjects were classified as other racial/ethnic groups, primarily Asian; 42% of subjects were black and the remaining subjects were white. Attributable adverse experiences that occurred in ≥ 5% of patients were abdominal pain (17%), nausea (12%), vomiting (12%), headache (10%), diarrhea (8%), asthenia (8%), anorexia (5%), and dizziness (5%). Treatment was discontinued prematurely due to an adverse experience in 4 of 436 (0.9%) adolescents and adults treated with atovaquone and proguanil hydrochloride.. In two controlled trials, 116 pediatric patients (weighing 11 kg to 40 kg) (mean age 7 years) received atovaquone and proguanil hydrochloride for the treatment of malaria. The majority of subjects were black (72%); 28% were of ...
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Risk Summary Available data from published literature and postmarketing experience with use of atovaquone and proguanil hydrochloride in pregnant women are insufficient to identify a drug-associated risk for major birth defects, miscarriage, or adverse maternal or fetal outcomes. The proguanil component of atovaquone and proguanil hydrochloride tablets acts to inhibit parasitic dihydrofolate reductase; however, pregnant women and females of reproductive potential should continue folate supplementation to prevent neural tube defects [see Clinical Pharmacology (12.4)]. Pregnant women with malaria are at increased risk for adverse pregnancy outcomes (see Clinical Considerations). Atovaquone administered by oral gavage to pregnant rats and rabbits during the period of organogenesis was not associated with fetal malformations at plasma exposures approximately 7 times and equal to, respectively, the estimated human exposure for the treatment of malaria based on AUC. Proguanil administered to pregnant ...
Malarone (Atovaquone / Proguanil Hydrochloride) - Drug Guide - AntiinfectiveMeds.com
Malarone belongs to a group of medicines called antimalarials. It contains two active ingredients, atovaquone and proguanil hydrochloride. Malaria is spread by the bite of an infected mosquito, which passes the malaria parasite (Plasmodium falciparum) into the bloodstream.
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If you have taken it before and were fine on it, then you can start 1.5 weeks before travel. It wasnt scientifically. What are the potential side . knowlesi, a parasite of Old World (Eastern Hemisphere) monkeys, has been documented as a cause side effects malarone chloroquine of human infections and some deaths in Southeast Asia Chloroquine phosphate is an expensive drug used to treat or prevent malaria infections.It is also used to treat amebiasis.It is more popular than comparable drugs. It is used to treat and prevent malaria, including chloroquine-resistant malaria. Chloroquine can also be used to treat malaria after you get it. Overdose Chloroquine is very toxic in overdosage; overdosage is extremely hazardous and …. Decreased Appetite. Oct 10, 2017 · Side Effects and What to Do About Them Chloroquine (Aralen) Side effects are normally mild and include: headache, loss of appetite, Atovaquone/Proguanil (Malarone) Serious and unusual reactions side effects malarone chloroquine are: ...
Clinical experience with atovaquone on a treatment investigational new drug protocol for Pneumocystis carinii pneumonia | RTI
The clinical experience of human immunodeficiency virus (HIV) + patients treated with oral atovaquone for acute Pneumocytstis carinii pneumonia (PCP) under a Treatment Investigational New Drug (IND) protocol (mild or moderate PCP) and an Open-Label Study protocol (severe PCP) was evaluated. A total of 940 patients intolerant of or unresponsive to trimethoprimsulfamethoxazole were enrolled from private practices, clinics, and institutional HIV treatment centers in the United States. Demographics data and the history and severity of PCP were collected at enrollment.
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The patent for Malarone, an anti malarial drug ran out last year and you can now buy generic (unbranded, but identical) tablets at a highly reduced price. After shopping around extensively for a weeks worth of the drug being quoted upwards of £50 for the course (16 tablets). I found that ASDA sell it at £1 per tablet, which is less than half the price of any other high street pharmacy and 65p less per tablet than the cheapest online pharmacy I could find. Hope this helps anyone trying to travel on a budget ...
Malaria: A review of drugs for prevention of malaria - Journal of Asian Health
According to the guidelines for India Chemoprophylaxis should be administered only in selective groups in high P.falciparum endemic areas. Use of personal protection measures is encouraged for pregnant women and other vulnerable population including travellers. However, for longer stay of Military and Para-military forces in high Pf endemic areas, the practice of chemoprophylaxis is to be followed wherever appropriate. For Short term chemoprophylaxis (up to 6 weeks) Doxycycline, is the drug of choice. Chemoprophylaxis for longer stay (more than 6 weeks) is with Mefloquine.. Regimens currently recommended for use in South Africa (2009), include Mefloquine, Doxycycline or Atovaquone - proguanil.. Guidelines from the Health Protection Agency Advisory Committee on Malaria Prevention (ACMP) in UK travellers (2007) recommend Mefloquine, or Doxycycline or Atovaquone/Proguanil for travel to high risk areas of Bangladesh and India. Chloroquine plus proguanil is recommended as an alternative. For ...
Antibiotics Manual: A Guide to commonly used antimicrobials | Infectious Disease & Microbiology | Medicine, Nursing & Dentistry...
Preface xvi. Abacacavir (Ziagen) 435. Abacavir + Lamivudine + Dolutegravir (Triumeq) 381. Acyclovir (Zovirax) 442. Adefovir (Hepsera) 187. Albendazole (Albenza) 3. Amikacin (Amikin) 9. Amoxicillan 11. Amoxicillin-Clavulanate (Augmentin, Augmentin 600ES, Augmentin XR) 32. Amphotericin B (Fungizone) 169. Amphotericin B Colloidal Dispersion - ABCD (Amphotec) 13. Amphotericin B Lipid Complex (Abelcet) 1. Ampicillin 15. Ampicillin-Sulbactam (Unasyn) 394. Anidulafungin (Eraxis) 149. Artemether/Lumefantrine (Coartem) 92. Artesunate 27. Atazanavir (Reyataz) 317. Atazanavir + Cobicistat (Evotaz) 152. Atovaquone (Mepron) 240. Atovaquone/Proguanil (Malarone) 230. Azithromycin (Zithromax, Zmax) 437. Aztreonam (Azactam) 40. Bedaquiline (Sirturo) 337. Benznidazole 51. Bithionol (Bitin) 57. Capreomycin (Capastat) 62. Caspofungin (Cancidas) 60. Cefaclor 66. Cefadroxil (Duricef) 135. Cefamandole (Mandol) 232. Cefazolin (Ancef) 18. Cefdinir (Omnicef) 270. Cefditoren Pivoxil (Spectracef) 343. Cefepime (Maxipime) ...
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A 50-year-old Nigerian man was admitted for generalized non febrile seizures. Two weeks before his GP prescribed antimalaric prophilaxis with clorochine for a planned trip in his home country. He suffered of a minor stroke 2 years before with no residual disability. He had also history of arterial hypertension treated with ace inhibitors and aspirin. At admission he was treated with lorazepam i.v. for a second generalized crisis at admission, and started carbamazepine 1000 per day. No other critical events were found during in hospital staying. A CT scan demonstrated the known subcortical right hemispheric hypodensity with no sulcal effacement or swelling features. Three months later carbamazepine was gradually intterrupted. After few months a new trip to Lagos was planned and chosen an antimalaric prophilaxis with Proguanil/Atovaquone (Malarone). The drug was well tolerated and no side effects were detected.. Take home message ...
What Is Pharmacology - Proguanil - Medicalrealm
Proguanil is an anti malarial drug which is given orally. Proguanil is also known as schizonticide. Proguanil is useful as a chemoprophylaxis against malaria.
RIFATER - Neurology Advisor
See Contraindications. Concomitant hepatotoxic agents: may cause fatal liver dysfunction. Concomitant alcohol may be associated with higher incidence of isoniazid hepatitis. Avoid tyramine- and histamine-containing foods, halothane. Monitor prothrombin time with concomitant anticoagulants. May potentiate anticonvulsants (eg, phenytoin), benzodiazepines, haloperidol, ketoconazole, theophylline, warfarin; adjust dose. May antagonize anticonvulsants, digoxin, antiarrhythmics, oral anticoagulants, azole antifungals, barbiturates, β-blockers, calcium channel blockers, chloramphenicol, clarithromycin, fluoroquinolones, cyclosporine, cardiac glycosides, clofibrate, diazepam, doxycycline, haloperidol, levothyroxine, oral or systemic hormonal contraceptives (consider nonhormonal methods), methadone, oral hypoglycemics, dapsone, corticosteroids, narcotic analgesics, progestins, quinine, tacrolimus, theophylline, tricyclic antidepressants, zidovudine, atovaquone, enalapril, sulfasalazine. May be ...
The (In)Adequacy of Darwinian Evolution
Joseph Bozorgmehr also notes that [i]n many instances...a loss of function and regulation in a harsh or unusual environment can have a beneficial outcome and thus be selected for-bacteria tend to evolve resistance to antibiotics in such a way through mutations that would otherwise adversely affect membrane permeability.20. Parasites. Humans have been battling malaria for thousands of years. The advent of modern medicine provided us with a weapon to finally beat this ravaging parasite once and for all. Or so we thought. Unfortunately for us, malaria has been able to develop immunity to every drug weve thrown at it. For example, malaria quickly developed resistance to Atovaquone. All that was required to circumvent the effectiveness of this drug was a single point mutation at position 268 in a single malarial gene. The odds of developing this particular mutation are one in a trillion (1012). While those odds would be difficult to overcome for most organisms (such as human beings or beetles), ...
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Effect of oral proguanil on human lymphocyte proliferation
In vitro studies have indicated that the antifolates pyrimethamine [4, 6] and cycloguanil (the active metabolite of proguanil) suppress the proliferation of stimulated human lymphocytes; proguanil has no effect . During the early growth phase of the cells, 14C-thymidine (14C-TdR) incorporation is increased by pyrimethamine and cycloguanil, reflecting blockage of endogenous TdR synthesis . Proguanil (Paludrine) is increasingly being used for malaria prophylaxis. It is considered the most innocuous of the antimalarials currently employed. Since nothing is known about the effect of oral proguanil on human lymphocytes, the present study was undertaken. Little information is available about the serum levels of proguanil and cycloguanil following ingestion of prophylactic doses . Therefore, the serum concentrations of proguanil and cycloguanil were estimated, to allow comparison with previous in vitro studies [2 ...
The Hospital for Sick Children - Prophylactic use of antimalarials during pregnancy
Doxycycline. There is no evidence for human teratogenicity with doxycycline use during pregnancy. 8 Despite this, the main concern with doxycycline, like tetracycline, is the risk to the fetus of inhibition of bone growth and discoloration and dysplasia of the teeth, 3 which can occur during the period of calcification beyond the fourth month of gestational age. 4 Because of the potential harm, doxycycline is not recommended during pregnancy. However, keeping in mind that treatment is continued for 4 weeks after leaving the malaria-endemic area, 9 doxycycline can be considered as long as treatment is completed by the fourth month of pregnancy.. Atovaquone-proguanil. Proguanil has been used as a malarial prophylactic agent for decades, with no known toxic effects on the fetus. 10 Four small 3-day treatment studies with the atovaquone-proguanil combination in the second and third trimesters of pregnancy did not identify any adverse effects in the fetuses or newborns. 11-14 In a recent ...
Malaria Prophylaxis. The ABCD of Malaria Prophylaxis. | Patient
Learn about The ABCD of malaria prophylaxis and the awareness of risk in Malaria Prophylaxis. Learn more about Malaria Prophylaxis.
Search Results for mefenamic acid | AKJournals
HIV antiviral, CAS No. 154598-52-4), mefenamic acid (nonsteroidal anti-inflammatory, CAS No. 61-68-7), and atovaquone (antifungal and anti-parasite, CAS No. 95233-18-4) + proguanil HCl (antimalarial, CAS No. 637-32-1). In addition, two previously. ...
Malaria research - The Travel Doctor
I am pleased to announce our latest research project: my staff and I are participating in the following very important initiative.. 3 Day Malarone Acceptability and Tolerability research project (3MAT). Malaria is one of the most common causes of fever in Australian travellers, with approximately 400 cases reported each year in Australia. Most travellers who develop malaria did not take anti-malarial medications, or did not take the medications properly (e.g. forgot to take tablets). Malaria is a serious illness and can potentially be fatal.. A research project is being conducted with the aim to make it easier and cheaper to take malaria pills and thus reduce the risk of malaria in travellers. Malarone is a safe and effective anti-malarial medication. The standard dosage of Malarone for prevention of malaria is one tablet per day, starting 2 days before travelling to a malaria area, daily while in a malaria area, and continuing until 7 days after leaving the malaria area.. Research has shown ...
Malaria continues to be one of the main preeminent and pernicious global health problems affecting humans -Free Admission Essay...
Thus far, malaria control has primarily focused on destroying mosquito breeding sites, using insecticides and preventing human contact using mosquito nets and screens (White, 2004). However, malaria predominantly affects lesser economically developed countries and thus the cost of treatment serves as a barrier to disease eradication. Anti-malarial drugs are some of the most common medications provided in tropical countries. They generally function by inhibiting specific enzymes or making the environment difficult for the parasite to survive in (Basore et al., 2015). Drugs are relatively cheaper, widely available and, as there is no vaccine, they currently provide the most effective method of treatment (White, 2004). One such class is Atovaquone. It works by inhibiting mitochondrial electron transport in the malarial parasite and preventing the build-up of an electrochemical gradient (Vaidya and Mather, 2000). This would prevent Plasmodium parasites from producing ATP via oxidative ...
JCI Insight - cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses
Our investigations reveal that cGAS contributes to parasite control, which is essential for the formation of GC-derived humoral immunity. The ability to simultaneously identify and analyze endogenous polyclonal antigen-specific CD4+ T cells and B cells responding to Plasmodium has revealed a profound effect of innate immune control of parasitemia. Control of parasitemia is important for timely development of the GC response, a response critical for both the efficient generation of high-affinity antibodies and durable immune memory (59-62). Furthermore, our ability to track parasitemia throughout the course of infection combined with the potential to rapidly clear blood-stage infection with atovaquone provided us with an elegant system in which the effects of innate control of parasite burden could be disentangled from the effects of early innate signals on the adaptive immune response. Specifically, the collapse of the GC response in cGAS-/- mice as parasitemia persisted could be abolished with ...
Oxidative Phosphorylation as an Emerging Target in Cancer Therapy. - Department of Oncology
Cancer cells have upregulated glycolysis compared with normal cells, which has led many to the assumption that oxidative phosphorylation (OXPHOS) is downregulated in all cancers. However, recent studies have shown that OXPHOS can be also upregulated in certain cancers, including leukemias, lymphomas, pancreatic ductal adenocarcinoma, high OXPHOS subtype melanoma, and endometrial carcinoma, and that this can occur even in the face of active glycolysis. OXPHOS inhibitors could therefore be used to target cancer subtypes in which OXPHOS is upregulated and to alleviate therapeutically adverse tumor hypoxia. Several drugs including metformin, atovaquone, and arsenic trioxide are used clinically for non-oncologic indications, but emerging data demonstrate their potential use as OXPHOS inhibitors. We highlight novel applications of OXPHOS inhibitors with a suitable therapeutic index to target cancer cell metabolism. Clin Cancer Res; 24(11); 2482-90. ©2018 AACR.
Various analytical methods for formulations, raw materials, APIs and intermediates have been developed at SDPARC. Instrumental methods developed include, Proguanil Hydrochloride, Forskolin, Guggulsterone, Many dissolutions methods have been developed and validated at the centre. Methods for estimating residual solvents and organic volatile impurities are also developed and validated at the centre.. ...
What are the side effects of proguanil? | Anti-Infective Agent - Sharecare
The most common side effects of proguanil (Malarone) are vomiting, headache, diarrhea, loss of appetite, nausea, and mouth sores. Some people temporar
Which medications are used to treat malaria during pregnancy?
Medications that can be used for the treatment of malaria in pregnancy include chloroquine, quinine, atovaquone-proguanil, clindamycin, mefloquine (avoid in first trimester), sulfadoxine-pyrimethamine... more
It works by killing the parasites in the blood and also in the liver. It is effective against strains of falciparum malaria which may be resistant to other antimalarials and so is especially useful for those travelling to places where there is a high risk of encountering malaria which is resistant to other drugs. It would be particularly useful for those individuals who cannot tolerate, or who are unable to take mefloquine ...
Proguanil for malaria prevention. Travel related disease drugs | Patient
Proguanil is used to prevent malaria. It is usually used in combination with another antimalarial medicine to increase its effectiveness.
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Trevor M. Jones
Atovaquone (PCP/Malaria); Exosurf (infant respiratory distress); Mivacron and Nuromax (neuromuscular blockade); Wellferon ( ...
COVID-19 drug repurposing research
... and atovaquone. Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases. ...
The addition of proguanil has shown to reduce resistance to atovaquone and increase the ability of atovaquone to trigger a ... "Atovaquone And Proguanil (Oral Route) Side Effects - Mayo Clinic". www.mayoclinic.org. Archived from the original on 2016-11-09 ... "Atovaquone and Proguanil Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 20 ... In the United States and Canada it is only available in combination as atovaquone/proguanil. Proguanil is used for the ...
Coenzyme Q - cytochrome c reductase
... atovaquone). Also propylhexedrine inhibits cytochrome c reductase. A small fraction of electrons leave the electron transport ...
November 2000). "Atovaquone and azithromycin for the treatment of babesiosis". N. Engl. J. Med. 343 (20): 1454-1458. doi: ... treatment regimens have been increasingly leaning towards oral atovaquone with oral azithromycin. The latter are preferred, as ...
... or the combination of atovaquone/proguanil (Malarone)-are frequently used for prevention. Doxycycline and the atovaquone/ ... Atovaquone-proguanil is effective against uncomplicated falciparum with a possible failure rate of 5% to 10%; the addition of ... Blanshard A, Hine P (15 Jan 2021). "Atovaquone-proguanil for treating uncomplicated Plasmodium falciparum malaria" (PDF). ... except for atovaquone/proguanil, which only needs to be started two days before and continued for seven days afterward). The ...
Doxycycline and atovaquone/proguanil provide protection within one to two days and may be better tolerated. If a person becomes ... In the mefloquine arm, 5% of the users reported severe events requiring medical attention, vs 1.2% in the atovaquone-proguanil ... October 2001). "Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a ... Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil. Roughly 67% of participants in the ...
... is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone. It is a promising compound for ... Its mode of action is thus likely to be similar to that of the antimalarial drug atovaquone, a similar 2-hydroxy-1,4- ...
Anina D. Murphy & Naomi Lang-Unnasch (1999). "Alternative Oxidase Inhibitors Potentiate the Activity of Atovaquone against ...
However, more recent work has indicated that, while proguanil is synergistic with the drug atovaquone (as in the combination ... Srivastava IK, Vaidya AB (June 1999). "A mechanism for the synergistic antimalarial action of atovaquone and proguanil". ... Thapar MM, Gupta S, Spindler C, Wernsdorfer WH, Björkman A (May 2003). "Pharmacodynamic interactions among atovaquone, ... Malarone), cycloguanil is in fact antagonistic to the effects of atovaquone, suggesting that, unlike cycloguanil, proguanil may ...
Atovaquone is recommended to be used only in combination with another anti-malarial compound as the selection of resistant ... A liquid oral suspension of Atovaquone is available under the name Mepron. Primaquine is a highly active 8-aminoquinolone that ... However it is useful in prophylaxis when combined with atovaquone or chloroquine (in areas where there is no chloroquine ... Atovaquone is available in combination with proguanil under the name Malarone, albeit at a price higher than Lariam. It is ...
Atovaquone-proguanil is an effective alternative in patients unable to tolerate chloroquine. Quinine may be used to treat vivax ... "Atovaquone and proguanil hydrochloride followed by primaquine for treatment of Plasmodium vivax malaria in Thailand". ...
Cohn, L.A.; Birkenheuer, A.J.; Brunker J.D.; Ratcliff E.R.; Craig, A.W. (2011). "Efficacy of Atovaquone and Azithromycin or ... Cohn, L.A.; Birkenheuer, A.J., Brunker J.D., Ratcliff E.R., Craig, A.W. (2011). "Efficacy of Atovaquone and Azithromycin or ... 60% of sick cats treated with supportive care and the combination of the anti-malarial drug atovaquone and the antibiotic ... The most often used treatments for cytauxzoonosis are imidocarb dipropionate and a combination of atovaquone and azithromycin. ...
Peter Gottfried Kremsner
Lell B, Luckner D, Ndjavé M, Scott T, Kremsner PG (March 1998). "Randomised placebo-controlled study of atovaquone plus ... He has been principal investigator on key studies for the development of atovaquone/proguanil, artesunate/amodiaquine, ...
The combination atovaquone-proguanil may be used in those patients who are unable to take chloroquine for whatever reason. An ... Radloff PD, Philipps J, Hutchinson D, Kremsner PG (1996). "Atovaquone plus proguanil is an effective treatment for Plasmodium ...
In mild-to-moderate babesiosis, the treatment of choice is a combination of atovaquone and azithromycin. This regimen is ...
International travelers to endemic zones are advised chemoprophylaxis with antimalarial drugs like Atovaquone-proguanil, ...
In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. The Centers ...
Mefloquine, doxycycline, and atovaquone-proguanil appear to be equally effective at reducing the risk of malaria for short-term ... Mefloquine (Lariam), or doxycycline (available generically), or the combination of atovaquone and proguanil hydrochloride ( ... atovaquone/proguanil (Malarone) 1 tablet daily (started one day before travel, and continued for 1 week after returning). Can ... however mefloquine is not always as well tolerated when compared with atovaquone-proguanil. There is low-quality evidence ...
Other medications that are used, alone or in combination, include pentamidine, trimetrexate, dapsone, atovaquone, primaquine, ... In immunocompromised patients, prophylaxis with co-trimoxazole (trimethoprim/sulfamethoxazole), atovaquone, or regular ...
Dihydrofolate reductase inhibitor
Cycloguanil, a metabolite of proguanil (a component of the oral antimalarial atovaquone-proguanil, or Malarone) Huennekens FM ( ...
The medications prescribed for latent toxoplasmosis are: Atovaquone - an antibiotic that has been used to kill Toxoplasma cysts ... Djurković-Djaković O, Milenković V, Nikolić A, Bobić B, Grujić J (2002). "Efficacy of atovaquone combined with clindamycin ... inside AIDS patients Clindamycin - an antibiotic that, in combination with atovaquone, seemed to optimally kill cysts in mice ...
For travellers returning to nonendemic countries, atovaquone/proguanil, artemether/lumefantrineany and quinine plus doxycycline ...
... proguanil with atovaquone), are often used when oral therapy is required. Quinine ethyl carbonate is tasteless and odourless, ...
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Malarone (a combination of atovaquone and proguanil) seldom has side effects, but headache, nausea, vomiting and abdominal pain ...
"Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo(2)) of the cytochrome b ... berghei are associated with resistance to the anti-malarial drug atovaquone. Human genes encoding cytochrome b proteins include ...
... and atovaquone. Mitochondria that lack their own DNA have been found in a marine parasitic dinoflagellate from the genus ...
Institute for Tropical Medicine Tübingen
The institute's achievements include contributions to the development of malaria drugs, such as atovaquone-proguanil, ...
... atovaquone, sulfadoxine/pyrimethamine, mefloquine, and artemisinin. In all cases, parasites resistant to a given drug have ...
These applications include purgative (sennosides), antimicrobial and antiparasitic (rhein and saprorthoquinone, atovaquone), ...
Atovaquone | SpringerLink
Atovaquone: MedlinePlus Drug Information
Atovaquone: learn about side effects, dosage, special precautions, and more on MedlinePlus ... When atovaquone is used to treat pneumonia, it is usually taken with meals twice a day for 21 days. When atovaquone is used to ... Before taking atovaquone,. *tell your doctor and pharmacist if you are allergic to atovaquone, any other medications, or any of ... Take atovaquone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. ...
Atovaquone and Proguanil: MedlinePlus Drug Information
Atovaquone and Proguanil: learn about side effects, dosage, special precautions, and more on MedlinePlus ... The combination of atovaquone and proguanil comes as a tablet to take by mouth. If you are taking atovaquone and proguanil to ... Always take atovaquone and proguanil with food or a milky drink. Take atovaquone and proguanil at around the same time every ... Before taking atovaquone and proguanil,. *tell your doctor and pharmacist if you are allergic to atovaquone and proguanil, any ...
atovaquone/proguanil (Malarone): Side Effects and Dosage
Read more about the prescription drug atovaquone/proguanil oral (Malarone). ... Consumer information about the medication atovaquone/proguanil oral (Malarone) side effects, drug interactions, recommended ... atovaquone and proguanil. *What is atovaquone-proguanil-oral, and how does it work (mechanism of action)? ... Combining atovaquone/proguanil with tetracycline can lower atovaquone levels in the body, leading to lack of effectiveness of ...
Atovaquone - Wikipedia
Clinical trials of atovaquone for the treatment of COVID-19 are planned.[when?] Atovaquone has also been found to inhibit human ... Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. Atovaquone is a medication ... "Atovaquone Oral SUSPENSION- atovaquone suspension". DailyMed. 10 December 2019. Retrieved 18 September 2020. Hughes W, Leoung G ... In addition, atovaquone has the advantage of not causing myelosuppression, which is an important issue in patients who have ...
Atovaquone (Oral Route) Side Effects - Mayo Clinic
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
atovaquone and proguanil
... is a combination medicine used to treat or prevent malaria, a disease caused by parasites. These ... What is atovaquone and proguanil?. Atovaquone and proguanil is a combination medicine used to treat or prevent malaria, a ... Atovaquone-Proguanil Hydrochloride. slide 3 of 5, Atovaquone-Proguanil Hydrochloride,. 250 mg-100 mg, round, pink, imprinted ... Atovaquone-Proguanil Hydrochloride. slide 4 of 5, Atovaquone-Proguanil Hydrochloride,. 250 mg-100 mg, round, pink, imprinted ...
Mepron (Atovaquone): Side Effects, Interactions, Warning, Dosage & Uses
Atovaquone) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related ... Atovaquone is a quinone antimicrobial drug [see Microbiology].. Pharmacokinetics. Absorption. Atovaquone is a highly lipophilic ... Table 6: Relationship between Plasma Atovaquone Concentration and Successful Treatment. Steady-state Plasma Atovaquone ... MEPRON (atovaquone) is a quinone antimicrobial drug for oral administration. The chemical name of atovaquone is trans-2-[4-(4- ...
Atovaquone / proguanil and citalopram Drug Interactions - Drugs.com
View drug interactions between atovaquone / proguanil and citalopram. These medicines may also interact with certain foods or ... atovaquone / proguanil. A total of 113 drugs (512 brand and generic names) are known to interact with atovaquone / proguanil. ... Atovaquone / proguanil is in the drug class antimalarial combinations.. *Atovaquone / proguanil is used to treat the following ... There were no interactions found in our database between atovaquone / proguanil and citalopram. However, this does not ...
DailyMed - ATOVAQUONE AND PROGUANIL HYDROCHLORIDE tablet
Atovaquone and Proguanil hydrochloride* n=206. Atovaquone and Proguanil hydrochloride† n=381. Placebo n=140. Atovaquone and ... ATOVAQUONE (UNII: Y883P1Z2LT) (ATOVAQUONE - UNII:Y883P1Z2LT) ATOVAQUONE. 250 mg. PROGUANIL HYDROCHLORIDE (UNII: R71Y86M0WT) ( ... atovaquone 250 MG / proguanil HCl 100 MG Oral Tablet. PSN. 2. 864675. atovaquone 250 MG / proguanil hydrochloride 100 MG Oral ... Absorption of atovaquone may be reduced in patients with diarrhea or vomiting. If atovaquone and proguanil hydrochloride is ...
Atovaquone Reviews | Everyday Health
See what others have said about Atovaquone, including the effectiveness, ease of use and side effects. ... Atovaquone received an overall rating of 10 out of 10 stars from 1 reviews. ... Atovaquone*Reviews. Atovaquone Reviews. 1 people have reviewed this drug. 5*****. 5 Stars ... Rated Atovaquone for Pneumocystis Pneumonia Prophylaxis Report The taste is bad but it does the job. I did notice that about an ...
ATOVAQUONE SUSPENSION - ORAL (Mepron) side effects, medical uses, and drug interactions.
Read more about the prescription drug ATOVAQUONE SUSPENSION - ORAL. ... Consumer information about the medication ATOVAQUONE SUSPENSION - ORAL (Mepron), includes side effects, drug interactions, ... GENERIC NAME: ATOVAQUONE SUSPENSION - ORAL (a-TOE-va-kwone). BRAND NAME(S): Mepron. Medication Uses , How To Use , Side Effects ... The amount of atovaquone that gets into the body increases if it is taken with meals.Dosage is based on your age, medical ...
Atovaquone and proguanil Uses, Side Effects & Warnings - Drugs.com
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atovaquone oral Reviews and User Ratings: Effectiveness, Ease of Use, and Satisfaction
DailyMed - ATOVAQUONE AND PROGUANIL HYDROCHLORIDE tablet, film coated
ATOVAQUONE (UNII: Y883P1Z2LT) (ATOVAQUONE - UNII:Y883P1Z2LT) ATOVAQUONE. 250 mg. PROGUANIL HYDROCHLORIDE (UNII: R71Y86M0WT) ( ... atovaquone 250 MG / proguanil HCl 100 MG Oral Tablet. PSN. 2. 864675. atovaquone 250 MG / proguanil hydrochloride 100 MG Oral ... Absorption of atovaquone may be reduced in patients with diarrhea or vomiting. If atovaquone and proguanil hydrochloride is ... Each atovaquone and proguanil hydrochloride tablet contains 250 mg of atovaquone and 100 mg of proguanil hydrochloride USP. The ...
Atovaquone may Provide Long-Acting Protection against Malaria
A new injectable formulation of an anitimalarial drug atovaquone can provide long term protection against Plasmodium berghei, a ... Since atovaquone is already licensed for use in humans and the nanomedicine contains ingredients already used in other ... Atovaquone, a new long-acting injectable medicine can provide longer protection against malarial plasmodium infections, finds ... A long-acting injectable version of atovaquone aims to utilize nanotechnology to improve the delivery of an existing anti- ...
Malarone (Atovaquone and Proguanil Hcl): Side Effects, Interactions, Warning, Dosage & Uses
Atovaquone and Proguanil Hcl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, ... Table 4: Apparent Clearance for Atovaquone and Proguanil in Patients as a Function of Body Weight. Body Weight Atovaquone ... Atovaquone. Atovaquone was not teratogenic and did not cause reproductive toxicity in rats at doses up to 1,000 mg/kg/day ... Atovaquone and Proguanil. The combination of atovaquone and proguanil hydrochloride was not teratogenic in pregnant rats at ...
Lupin's pneumonia drug Atovaquone oral suspension receives USFDA approval | Business Standard News
As per IQVIA MAT June 2018 data, Atovaquone oral suspension, 750 mg/5 mL had annual sales of around $117.4 million in the US ... Read more about Lupins pneumonia drug Atovaquone oral suspension receives USFDA approval on Business Standard. ... Lupins pneumonia drug Atovaquone oral suspension receives USFDA approval As per IQVIA MAT June 2018 data, Atovaquone oral ... The company has received approval to market generic Atovaquone oral suspension USP in the strength of 750 mg/5 mL from the ...
Atovaquone Applied Onto The Bed Nets Could Stop Malaria Transmission
By preventing mosquitoes from getting infected with malaria with the help of anti-malarial compound atovaquone, the researchers ... The researchers had similar success when using other compounds similar to atovaquone. While atovaquone effectively killed ... Applying antimalarial compound atovaquone to any surface could lead to drop in malaria transmission as it was found to ... The results show us that treating bed nets with atovaquone or similar compounds would be an effective way to reduce the burden ...
atovaquone and proguanil
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Atovaquone-Proguanil - Side Effects, Dosage, Interactions - Drugs - Everyday Health
Atovaquone and proguanil are medications to treat malaria, a disease caused by parasites. These medicines work by interfering ... Use atovaquone and proguanil regularly to best prevent malaria. If you stop using the medication early for any reason, talk to ... Atovaquone and proguanil should not be used to treat malaria in a child who weighs less than 11 pounds, and should not be used ... Atovaquone and proguanil can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your ...
Atovaquone and Proguanil HydrochloridePediatric Tablets | Atovaquone and Proguanil Hydrochloride
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Atovaquone and Azithromycin Combination for Confirmed COVID-19 Infection - Full Text View - ClinicalTrials.gov
Drug: Atovaquone/Azithromycin Atovaquone 750 mg PO Q12H for up to 10 Days Azithromycin 500 mg PO Daily 1 followed by 250 mg PO ... Experimental: Atovaquone/Azithromycin Atovaquone 750 mg PO Q12H for up to 10 days Azithromycin 500 mg PO Day 1 followed by 250 ... History of hypersensitivity to atovaquone and/or azithromycin.. *History of known intolerance to atovaquone and/or azithromycin ... Atovaquone and Azithromycin Combination for Confirmed COVID-19 Infection. The safety and scientific validity of this study is ...
Atovaquone Proguanil 250mg/100mg | Malarone Tablets | Chemist Direct
Buy Atovaquone Proguanil 250mg/100mg Malarone Tablets at Chemist Direct. It is used for the treatment of malaria and to ... Generic Malarone (atovaquone 250mg) (proguanil 100mg) tablets are brought to you by our Online Doctor Service to help prevent ... Generic Malarone (atovaquone 250mg) (proguanil 100mg) tablets have 2 uses. They are used to effectively prevent malaria as well ... Atovaquone Proguanil 250mg/100mg (Generic - Malarone Tablets): Always take Malarone exactly as your doctor has told you. ...
Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent | Blood Journal
The cutoff of 55 days of atovaquone treatment to separate the patients into "high atovaquone" and "low atovaquone" groups was ... 55 days of atovaquone treatment within the first 150 days posttransplant ("high atovaquone") or otherwise ("low atovaquone"). P ... Atovaquone is known to bind to mitochondrial cytochrome bc1 complex in parasites.35 Although the affinity of atovaquone for ... Atovaquone shows anticancer efficacy in vitro, in vivo, and in a retrospective study of AML patient outcomes after atovaquone ...
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Atovaquone Supplier | CAS 95233-18-4 | Tocris Bioscience
View and buy high purity Atovaquone from Tocris Bioscience. Inhibits complex III of mitochondrial electron transport chain in ... Keywords: Atovaquone, Atovaquone supplier, atovaquone, antimalarial, antiparasitic, mitochondria, respiration, inhibitors, ... Reviews for Atovaquone. There are currently no reviews for this product. Be the first to review Atovaquone and earn rewards! ... Citations for Atovaquone. Citations are publications that use Tocris products. Currently there are no citations for Atovaquone ...
Drug Interaction Study Between Atovaquone and Antiretroviral Agents in HIV-1 Infected Patients - Full Text View -...
Atovaquone, proguanil drug combination. Atovaquone. Proguanil. Anti-Retroviral Agents. Anti-Infective Agents. Antimalarials. ... there are indications that certain anti-HIV agents may decrease atovaquone plasma levels by induction of atovaquone metabolism. ... atazanavir/ritonavir or efavirenz have lower atovaquone plasma levels than healthy volunteers after a single dose of atovaquone ... Drug Interaction Study Between Atovaquone and Antiretroviral Agents in HIV-1 Infected Patients. The safety and scientific ...
Clinical experience with atovaquone on a treatment investigational new drug protocol for Pneumocystis carinii pneumonia | RTI
... patients treated with oral atovaquone for acute Pneumocytstis carinii pneumonia (PCP) under a Treatment Investigational New ... Clinical experience with atovaquone on a treatment investigational new drug protocol for Pneumocystis carinii pneumonia. ... White, A., LaFon, S., Rogers, M., Andrews, E., & Brown, N. (1995). Clinical experience with atovaquone on a treatment ... The clinical experience of human immunodeficiency virus (HIV) + patients treated with oral atovaquone for acute Pneumocytstis ...
PRIME PubMed | [Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and...
... clarithromycin and atovaquone were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad. ... Atovaquone Expanded Access Group.. *Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of ... AIDS-Related Opportunistic InfectionsAdultAnimalsAtovaquoneClarithromycinClindamycinDrug Therapy, CombinationFolic AcidHumans ... The second patient was successfully treated with atovaquone (750 mg/6 h) for 8 weeks and at 12 months of follow up with a ...
TabletsPlasmodium250mgProphylaxisChloroquineEfficacy of atovaquoneTabletMedicationCytochromeTake atovaquone and proguanilInteract with atovaquone and proguanilConcentrationsHighly lipophilicFine particles of atovaquoneTaking atovaquone and proguanilClinicalAntiprotozoalPatientsMetabolismInteractionsSuspensionAnti-malarial drugDrugsConcomitantCombinationEffects of atovaquoneTreated with proguanilAllergic to atovaquoneEffectiveness of atovaquoneBioavailability of atovaquoneQuinineUbiquinoneDrugPneumocystisHematopoietic stem cell transAbsorptionPreventionToxoplasmosisDosageMitochondrial electronVitro activityTreatmentInhibitorExcretionTetracycline
- Atovaquone and proguanil tablets are available in two combination strengths: 250/100 mg (adults) and 62.5/25 mg (pediatric). (medicinenet.com)
- Store Atovaquone and proguanil tablets should be stored between 15 C to 30 C (59 F to 86 F). (medicinenet.com)
- Atovaquone and proguanil hydrochloride tablets are for oral administration. (nih.gov)
- Atovaquone and proguanil hydrochloride tablets should be taken with food or a milky drink. (nih.gov)
- MALARONE (atovaquone and proguanil hydrochloride) Tablets (adult strength) and MALARONE (atovaquone and proguanil hydrochloride) Pediatric Tablets, for oral administration, contain a fixed-dose combination of the antimalarial agents atovaquone and proguanil hydrochloride. (rxlist.com)
- Generic Malarone (atovaquone 250mg) (proguanil 100mg) tablets are brought to you by our Online Doctor Service to help prevent the risk of being infected with malaria. (chemistdirect.co.uk)
- Please note, like all medicine, Generic Malarone (atovaquone 250mg) (proguanil 100mg) tablets can cause side effects - although this does not apply to everyone who has taken them. (chemistdirect.co.uk)
- Please read all packaging before taking Generic Malarone (atovaquone 250mg) (proguanil 100mg) tablets. (chemistdirect.co.uk)
- Atovaquone Proguanil 250mg/100mg (Generic - Malarone Tablets): Always take Malarone exactly as your doctor has told you. (chemistdirect.co.uk)
- Tablets (adult strength): 250 mg atovaquone and 100 mg proguanil hydrochloride. (gsksource.com)
- Be the first to review Atovaquone and Proguanil 250mg/100mg Single Tablet (Malarone generic tablets). (travelpharm.com)
- Atovaquone tablets may be crushed if necessary to make it easier to swallow. (odakeczane.com)
- Because atovaquone tablets and oral suspension do not produce the same amount of medicine in the blood, the tablets and the suspension cannot be switched and used in place of each other. (odakeczane.com)
- Atovaquone/Proguanil Hydrochloride 250mg/100mg tablets are the generic version of Malarone. (pharmacydirectgb.co.uk)
- How do I take Atovaquone/Proguanil tablets? (postmymeds.co.uk)
- Atovaquone/Proguanil tablets are taken daily and should be started 1-2 days before entering endemic area and continued for 1 week after leaving. (postmymeds.co.uk)
- Children and adults weighing under 40kg can take Atovaquone/Proguanil Paediatric tablets but the daily dose will have to be calculated according to their weight. (postmymeds.co.uk)
- Anti-malaria tablets: one brand of atovaquone/prog. (travelhealthpro.org.uk)
- Oral (Children 31-40 kg) Three pediatric tablets (atovaquone 187.5 mg/proguanil 75 mg) once daily 1-2 days prior to entering endemic area and continued for seven days following return. (thefreedictionary.com)
- Atovaquone and cycloguanil (an active metabolite of proguanil) are active against the erythrocytic and exoerythrocytic stages of Plasmodium spp. (nih.gov)
- Atovaquone, a new 'long-acting' injectable medicine can provide longer protection against malarial plasmodium infections, finds a new study. (medindia.net)
- Applying antimalarial compound atovaquone to any surface could lead to drop in malaria transmission as it was found to completely block Plasmodium falciparum from developing in the mosquito, finds a new study. (medindia.net)
- Mosquitoes that landed on surfaces coated with the anti-malarial compound atovaquone were completely blocked from developing Plasmodium falciparum (P. falciparum), the parasite that causes malaria, according to new research led by Harvard T.H. Chan School of Public Health. (medindia.net)
- The in vitro activity of atovaquone (566C80) was evaluated and compared with that of chloroquine, quinine, mefloquine, halofantrine, artemether, pyrimethamine, and cycloguanil against African isolates and clones of Plasmodium falciparum using an isotopic, semimicro, drug susceptibility test. (ajtmh.org)
- It has been previously reported that the synergistic interaction between the components of Malarone, atovaquone (ATV) and proguanil (PG), is reduced to an indifferent interaction in ATV-resistant Plasmodium yoelii parasites ( 25 ). (asm.org)
- Atovaquone and proguani hydrochloride compared with chloroquine or pyrimethamine/sulfodaxine for treatment of acute Plasmodium falciparum malaria in Peru. (semanticscholar.org)
- The combination of atovaquone‐proguanil (Malarone ® ) has shown high efficacy against Plasmodium falciparum with only mild side-effects. (biomedcentral.com)
- Finally, in patients with acute myelogenous leukemia treated with hematopoietic stem cell transplantation, extended use of atovaquone for Pneumocystis prophylaxis was associated with improved relapse-free survival. (bloodjournal.org)
- Malarone® (atovaquone/proguanil) is frequently used in malaria prophylaxis. (clinicaltrials.gov)
- The available data on the efficacy of atovaquone prophylaxis in Toxoplasma sero-positive stem cell transplant recipients remain limited, and other strategies, such as preemptive strategy using toxoplasma PCR or TMP-SMX desensitization should be considered in this setting. (ovid.com)
- There is limited data regarding the efficacy of prophylaxis with atovaquone/proguanil (A/P) against non-falciparum malaria in travelers. (eurekamag.com)
- Children qualified for PCP prophylaxis (on the basis of Centers for Disease Control and Prevention recommendations) were randomized to receive atovaquone-azithromycin or TMP-SMZ daily for ⩾2 years. (oup.com)
- Live attenuated oral cholera vaccine should be given at least 10 days before beginning antimalarial prophylaxis with chloroquine, although a study in children using the oral cholera vaccine suggested no decrease in immunogenicity when given with atovaquone-proguanil. (cdc.gov)
- Atovaquone/Proguanil hydrochloride is a generic medication used for malaria prophylaxis. (postmymeds.co.uk)
- A new, promising combination, azithromycin (AZ) plus atovaquone (ATQ), is currently under investigation inside a phase II/III medical trial (ACTG 254) to compare its efficiency and protection with those of trimethoprim-sulfamethoxazole in the prophylaxis of multiple opportunistic attacks in HIV-infected kids. (onetownmanyvoices.com)
- Atovaquone was highly active against the chloroquine-susceptible L-3 (geometric mean 50% inhibitory concentration [IC 50 ] = 0.978 nM) and L-16 clones (mean IC 50 = 0.680 nM) and against the multidrug-resistant FCM 29 clone (mean IC 50 = 1.76 nM). (ajtmh.org)
- Anti-malarial drugs, including lumefantrine, atovaquone and chloroquine in five-fold dilutions (range 0.05 ng/ml - 1 ug/mL) were diluted in culture medium supplemented with fasting or post-prandial 10% donor serum. (springermedizin.de)
- Participants were randomized to receive chloroquine alone or combined with artesunate, azithromycin or atovaquone-proguanil for all episodes of uncomplicated malaria for one year. (nih.gov)
- Malaria incidence (95% confidence interval) was 0.59 (.46-.74), .61 (.49-.76), .63 (.50-.79) and .68 (.54-.86) episodes/person-year for group randomized to receive chloroquine alone or in combination with artesunate, azithromycin or atovaquone-proguanil respectively and the differences were not statistically significant. (nih.gov)
- Chloroquine and atovaquone-proguanil at doses used for malaria chemoprophylaxis may be given concurrently with the oral typhoid vaccine. (cdc.gov)
- METHODS: The interaction of chloroquine, quinine, artemisinin, mefloquine, lumefantrine, atovaquone, dihydroartemisinin and proguanil, with transport activity of P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), bile salt export pump (BSEP) and multidrug resistance-associated proteins (MRP) 1-4 were analysed. (ru.nl)
- Similarly, chloroquine has also long been associated with symptoms similar to those caused by mefloquine [ 11 , 12 ], although as with atovaquone-proguanil and doxycycline, their occurrence with the use of chloroquine is not accompanied by warnings to discontinue the drug at their onset. (springer.com)
Efficacy of atovaquone2
- Therefore, using the hamster model, we determined the efficacy of atovaquone alone as well as atovaquone plus azithromycin for the treatment of experimental babesiosis. (ajtmh.org)
- Oz, H. (2014) Novel Synergistic Protective Efficacy of Atovaquone and Diclazuril on Fetal-Maternal Toxoplasmosis. (scirp.org)
- The combination of atovaquone and proguanil comes as a tablet to take by mouth. (medlineplus.gov)
- Each atovaquone and proguanil hydrochloride tablet contains 250 mg of atovaquone and 100 mg of proguanil hydrochloride USP. (nih.gov)
- Long-acting injectable version of a daily anti-malarial tablet (atovaquone) has now been developed. (medindia.net)
- Through the use of this technology, the trans-Atlantic research team developed an LAI version of a daily anti-malarial tablet (atovaquone) which provided prophylactic blood concentrations in mice for a period of 28 days. (medindia.net)
- Each MALARONE Tablet (adult strength) contains 250 mg of atovaquone and 100 mg of proguanil hydrochloride and each MALARONE Pediatric Tablet contains 62.5 mg of atovaquone and 25 mg of proguanil hydrochloride. (rxlist.com)
- One MALARONE Tablet (adult strength = 250 mg atovaquone/100 mg proguanil hydrochloride) per day. (rxlist.com)
- Atovaquone-proguanil is a combination oral medication that combines two drugs, atovaquone and proguanil, into a single tablet. (healthery.com)
- Atovaquone/proguanil, a combination tablet that can be taken to prevent malaria, is currently available in branded and non-branded forms. (travelhealthpro.org.uk)
- One adult strength tablet (atovaquone 250 mg/proguanil 100 mg) once daily 1-2 days prior to entering endemic area and continued for seven days following return. (thefreedictionary.com)
- Oral (Children 11-20 kg) One pediatric tablet (atovaquone 62.5 mg/proguanil 25 mg) once daily 1-2 days prior to entering endemic area and continued for seven days following return. (thefreedictionary.com)
- Atovaquone is also used to prevent PCP in teenagers and adults who cannot take another medication used for prevention. (medlineplus.gov)
- you should plan what to do in case you experience serious side effects from atovaquone and proguanil and have to stop taking the medication, especially if you are not near a doctor or pharmacy. (medlineplus.gov)
- Atovaquone and proguanil is an anti-malarial medication. (medicinenet.com)
- Combining atovaquone/proguanil with tetracycline can lower atovaquone levels in the body, leading to lack of effectiveness of the antimalarial medication. (medicinenet.com)
- Concomitant use of atovaquone/proguanil and rifampin or rifabutin can lower atovaquone levels approximately 50% and 34%, reducing effectiveness of malarial medication. (medicinenet.com)
- Atovaquone and proguanil (Malarone) oral is a medication prescribed to treat and prevent malaria. (medicinenet.com)
- Atovaquone, sold under the brand name Mepron, is a quinone antimicrobial medication for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP). (wikipedia.org)
- Atovaquone is a medication used to treat or prevent: For pneumocystis pneumonia (PCP), it is used in mild cases, although it is not approved for treatment of severe cases. (wikipedia.org)
- Atovaquone and proguanil may also be used for purposes not listed in this medication guide. (rexhealth.com)
- The amount of atovaquone that gets into the body increases if it is taken with meals.Dosage is based on your age, medical condition, and response to treatment.This medication works best when the amount of medicine in your body is kept at a constant level. (medicinenet.com)
- The study showed that atovaquone--an active ingredient in medication that's commonly used in humans to prevent and treat malaria--can be absorbed through mosquitoes' tarsi (legs) and prevents the insects from developing and spreading the parasite. (medindia.net)
- MEPRON (atovaquone) is a quinone antimicrobial medication for oral organization. (medicationkings.net)
- Atovaquone/Proguanil is medication used for malaria prevention. (postmymeds.co.uk)
- Although Atovaquone/Proguanil is a commonly used medication for the prevention of malaria, it is not suitable for everyone. (postmymeds.co.uk)
- Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia. (jlresearch.com.au)
- This medication is a combo drug, and it contains two medications: Atovaquone and Proguanil. (mydrugcenter.com)
- Molecular basis for atovaquone resistance in Pneumocystis jirovecii modeled in the cytochrome bc(1) complex of Saccharomyces cerevisiae" (PDF). (wikipedia.org)
- The rapid appearance of resistant malarial parasites after introduction of atovaquone (ATQ) drug has prompted the search for new drugs as even single point mutations in the active site of Cytochrome b protein can rapidly render ATQ ineffective. (uni-wuerzburg.de)
- Cytochrome bc1 complex (complex III) seems to serve as a highly discriminating molecular target for atovaquone in Plasmodia. (drugbank.com)
- In the present study, we report binding characteristics of trans and cis-isomers of atovaquone with cytochrome bc1 of yeast using docking technique in order to address the basic question, why trans isomer of atovaquone has much higher drug potency than that of its cis isomer? (ipl.org)
- Sequencing confirmed Tyr268Cys mutation in the cytochrome b gene, associated with atovaquone resistance, in isolates collected on days 29 and 34 and P. falciparum dihydrofolate reductase mutation Asn51Ile, associated with proguanil resistance in all successfully sequenced samples. (cdc.gov)
Take atovaquone and proguanil7
- Always take atovaquone and proguanil with food or a milky drink. (medlineplus.gov)
- Take atovaquone and proguanil at around the same time every day. (medlineplus.gov)
- Take atovaquone and proguanil exactly as directed. (medlineplus.gov)
- If you vomit within 60 minutes after you take atovaquone and proguanil, take another full dose. (medlineplus.gov)
- Your doctor may tell you not to take atovaquone and proguanil. (medlineplus.gov)
- How should I take atovaquone and proguanil? (rexhealth.com)
- Take atovaquone and proguanil at the same time each day with food or a milky drink. (drugs.com)
Interact with atovaquone and proguanil2
- Many other medications may also interact with atovaquone and proguanil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
- This list is not complete and other drugs may interact with atovaquone and proguanil. (everydayhealth.com)
- Over the course of the study, mosquitoes were exposed to different concentrations of atovaquone and were kept in the cups for different amount of times. (medindia.net)
- The study found that P. falciparum development was completely blocked at relatively low concentrations of atovaquone (100 μmol per m2) and when mosquitoes were exposed for just 6 minutes, which is comparable to the time wild mosquitoes spend on insecticide-treated bed nets. (medindia.net)
- The FDA-approved drug atovaquone is a novel, clinically available inhibitor of STAT3 at standard human plasma concentrations. (bloodjournal.org)
- We show that, at drug concentrations routinely achieved clinically in human plasma, atovaquone inhibits STAT3 phosphorylation, the expression of STAT3 target genes, and the viability of STAT3-dependent hematological cancer cells. (bloodjournal.org)
- The extent of plasma protein binding of atovaquone in human plasma is not affected by the presence of therapeutic concentrations of phenytoin, nor is the binding of this drug affected by the presence of atovaquone. (pediatriconcall.com)
- Rifampin: Coadministration of rifampin results in a significant decrease in average steady- state plasma atovaquone concentrations. (pediatriconcall.com)
- The study found that P. falciparum development was completely blocked at relatively low concentrations of atovaquone (100 ?mol per m 2 ) and when mosquitoes were exposed for just 6 minutes, which is comparable to the time wild mosquitoes spend on insecticide-treated bed nets. (innovationtoronto.com)
- CONCLUSIONS: Atovaquone and quinine significantly inhibit BCRP- and P-gp- mediated transport at concentrations within the clinically relevant prophylactic and therapeutic range. (ru.nl)
- Atovaquone rapidly decreases the OCR by more than 80% in a wide range of cancer cell lines at pharmacological concentrations. (ox.ac.uk)
Fine particles of atovaquone2
Taking atovaquone and proguanil6
- If you are taking atovaquone and proguanil to prevent malaria, you will probably start taking it once daily 1 or 2 days before you travel to an area where malaria is common, and then continue during your time in the area and for 7 days after you return. (medlineplus.gov)
- If you are taking atovaquone and proguanil to treat malaria, you will probably take it once daily for 3 days in a row. (medlineplus.gov)
- If you become pregnant while taking atovaquone and proguanil, call your doctor. (medlineplus.gov)
- If you are taking atovaquone and proguanil to prevent malaria, call your doctor immediately if you develop any of these symptoms. (medlineplus.gov)
- What should I discuss with my healthcare provider before taking atovaquone and proguanil? (rexhealth.com)
- In addition to taking atovaquone and proguanil, use protective clothing, insect repellents, and mosquito netting around your bed to further prevent mosquito bites that could cause malaria. (drugs.com)
- Clinical trials of atovaquone for the treatment of COVID-19 are planned. (wikipedia.org)
- Enhanced efficacy of the combination compared to either atovaquone or proguanil hydrochloride alone was demonstrated in clinical studies in both immune and non-immune patients (see CLINICAL STUDIES ). (nih.gov)
- The clinical experience of human immunodeficiency virus (HIV) + patients treated with oral atovaquone for acute Pneumocytstis carinii pneumonia (PCP) under a Treatment Investigational New Drug (IND) protocol (mild or moderate PCP) and an Open-Label Study protocol (severe PCP) was evaluated. (rti.org)
- The high in vitro activity of atovaquone without any in vitro evidence for cross-resistance with other antimalarial drugs against the naturally occurring malaria parasites is a factor that favors further development of the drug for clinical use. (ajtmh.org)
- Atovaquone has antifungal activity against Aspergillus and Fusarium clinical isolates, with Fusarium species being more sensitive to atovaquone than Aspergillus species. (arvojournals.org)
- Atovaquone's clinical trials were initially halted when it could not reliably cure patients due to the rapid acquisition of resistance to atovaquone. (washington.edu)
- Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. (semanticscholar.org)
- The Translational Genomics Research Institute (TGen), HonorHealth Research Institute, and HonorHealth have started enrolling patients for a clinical trial of atovaquone plus azithromycin to treat moderate-to-severe Covid-19. (clinicaltrialsarena.com)
- El-Sadr and colleagues from the AIDS Clinical Trials Group and the Community Program for Clinical Research on AIDS compared the effectiveness of atovaquone with that of dapsone in preventing PCP in patients with HIV infection who were intolerant to trimethoprim-sulfamethoxazole. (aafp.org)
- We are now undertaking clinical studies to assess whether atovaquone reduces tumour hypoxia in patients, thereby increasing the efficacy of radiotherapy. (ox.ac.uk)
- Clinical studies have shown atovaquone (ATQ), a new blood schizontocidal drug, in combination with proguanil (PROG) to be very effective in the treatment of acute multidrug-resistant falciparum malaria. (who.int)
- Our results provide insight into the complex biological effects of atovaquone, highlighting its potential as an anticancer therapy with novel and diverse mechanisms of action, and support further clinical evaluation of atovaquone for pediatric and adult AML. (zenodo.org)
- Atovaquone is in a class of medications called antiprotozoal agents. (medlineplus.gov)
- Atovaquone, an antiprotozoal and antipneumocystic agent, is predominantly cleared by biliary excretion of unchanged parent drug. (aspetjournals.org)
- Atovaquone is a broad-spectrum antiprotozoal drug with a novel mechanism of action, via inhibition of parasite mitochondrial electron transport, and a favorable safety profile. (semanticscholar.org)
- Atovaquone, the active ingredient in Mepron Oral Suspension is in a class of medications called antiprotozoal agents that work by stopping the growth of certain types of protozoa that can cause pneumonia. (discountdrugsfromcanada.com)
- Atovaquone (Mapren): antiprotozoal drug used to prevent and treat a very serious type of pneumonia called Pneumocystis carinii pneumonia (PCP), in individuals who experience serious side effects with SMZ-TMP (Sulfamethoxazole/Trimethoprim, brand name Bactrim). (encyclopedia.com)
- However, atovaquone may be used in patients who cannot tolerate, or are allergic to, sulfonamide medications such as TMP-SMX. (wikipedia.org)
- In addition, atovaquone has the advantage of not causing myelosuppression, which is an important issue in patients who have undergone bone marrow transplantation. (wikipedia.org)
- Atovaquone is given prophylactically to kidney transplant patients to prevent PCP in cases where Bactrim is contraindicated for the patient. (wikipedia.org)
- Oral atovaquone compared with intravenous pentamidine for Pneumocystis carinii pneumonia in patients with AIDS. (wikipedia.org)
- A population pharmacokinetic analysis demonstrated that the apparent volume of distribution of atovaquone (V/F) in adult and pediatric patients after oral administration is approximately 8.8 L/kg. (nih.gov)
- The elimination half-life of atovaquone is about 2 to 3 days in adult patients. (bioportfolio.com)
- These effects were also observed with atovaquone treatment of primary blasts isolated from patients with acute myelogenous leukemia or acute lymphocytic leukemia. (bloodjournal.org)
- The purpose of this study is to find out if HIV patients using HAART regimes with either lopinavir/ritonavir, atazanavir/ritonavir or efavirenz have lower atovaquone plasma levels than healthy volunteers after a single dose of atovaquone/proguanil. (clinicaltrials.gov)
- Atovaquone should be considered in the therapeutic regimen of patients with babesiosis who have either failed standard therapy or have become intolerant to such therapy. (ajtmh.org)
- The HonorHealth Research Institute and HonorHealth announced today the successful enrollment on a novel combination of atovaquone and azithromycin in patients with moderate-to-severe COVID-19 infection. (tgen.org)
- The combination of atovaquone and azithromycin has been previously studied in other infectious conditions and we hope that if proven active, it may represent a well-tolerated option for patients infected with COVID-19," said Michael S. Gordon, M.D., Medical Director of HonorHealth Research Institute and co-Principal Investigator of the trial. (tgen.org)
- Atovaquone absorption may be reduced in patients with diarrhea or vomiting. (gsksource.com)
- Atovaquone plus azithromycin combination is expected to offer well-tolerated option for Covid-19 patients. (clinicaltrialsarena.com)
- Atovaquone plus azithromycin combination was studied in other infectious disease and is expected to offer a well-tolerated option for patients infected with the novel coronavirus. (clinicaltrialsarena.com)
- Two patients were treated with sequential intravenous artesunate plus oral atovaquone/proguanil (AP) and one with oral AP. (cdc.gov)
- Patients were randomized to receive either 100 mg of dapsone daily or 1,500 mg of atovaquone suspension daily. (aafp.org)
- A total of 257 patients had either confirmed or probable PCP, including 122 patients in the atovaquone group and 135 in the dapsone group. (aafp.org)
- Of the 440 patients who died during the course of the study, 233 were in the atovaquone group and 208 in the dapsone group. (aafp.org)
- The authors conclude that atovaquone and dapsone are equally effective in preventing PCP in patients with HIV infection. (aafp.org)
- Atovaquone appears to be better tolerated and may be the preferred drug in patients who cannot take trimethoprim-sulfamethoxazole. (aafp.org)
- Atovaquone compared with dapsone for the prevention of Pneumocystis carinii pneumonia in patients with HIV infection who cannot tolerate trimethoprim, sulfonamides, or both. (aafp.org)
- IMSEAR at SEARO: Pharmacokinetics of proguanil in malaria patients treated with proguanil plus atovaquone. (who.int)
- Atovaquone comes as a suspension (liquid) to take by mouth. (medlineplus.gov)
- tell your doctor and pharmacist if you are allergic to atovaquone, any other medications, or any of the ingredients in atovaquone suspension. (medlineplus.gov)
- Each 5 mL of MEPRON suspension contains 750 mg of atovaquone and the inactive ingredients benzyl alcohol , flavor, poloxamer 188, purified water, saccharin sodium, and xanthan gum. (rxlist.com)
- MEPRON is a bright yellow, citrus-flavored, oral suspension containing 750 mg of atovaquone in 5 mL. (rxlist.com)
- MEPRON suspension (bright yellow, citrus-flavored) containing 750 mg atovaquone in 5 mL. (rxlist.com)
- Drug firm Lupin on Wednesday said it has received nod from the US health regulator to market its Atovaquone oral suspension used for prevention and treatment of a type of pneumonia. (business-standard.com)
- The company has received approval to market generic Atovaquone oral suspension USP in the strength of 750 mg/5 mL from the United States Food and Drug Administration (USFDA), Lupin said in a BSE filing. (business-standard.com)
- Every 5 mL of MEPRON suspension contains 750 mg of atovaquone and the inert fixings benzyl liquor, season, poloxamer 188, purged water, saccharin sodium, and thickener. (medicationkings.net)
- A long-acting injectable version of atovaquone aims to utilize nanotechnology to improve the delivery of an existing anti-malarial drug. (medindia.net)
- Which drugs or supplements interact with atovaquone-proguanil-oral? (medicinenet.com)
- Therefore, caution should be used when administering atovaquone concurrently with other highly plasma protein bound drugs with narrow therapeutic indices, as competition for binding sites may occur. (pediatriconcall.com)
- The in vitro responses between atovaquone and the other antimalarial drugs were not correlated, indicating the absence of in vitro cross-resistance. (ajtmh.org)
- Concomitant use of atovaquone/proguanil and metoclopramide ( Reglan , Reglan ODT, Metozol ODT , Octamide) may lower the amount of atovaquone that the body can absorb, leading to lack of effectiveness. (medicinenet.com)
- The combination of atovaquone and proguanil is used to treat a certain kind of malaria infection (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death) and to prevent a certain kind of malaria infection in travelers who visit areas where malaria is common. (medlineplus.gov)
- medical citation needed] Atovaquone, as a combination preparation with proguanil, has been commercially available from GlaxoSmithKline since 2000 as Malarone for the treatment and prevention of malaria. (wikipedia.org)
- Atovaquone and proguanil is a combination medicine used to treat or prevent malaria , a disease caused by parasites. (rexhealth.com)
- Atovaquone and proguanil hydrochloride is a fixed-dose combination of the antimalarial agents atovaquone and proguanil hydrochloride. (nih.gov)
- The combination of atovaquone and proguanil hydrochloride may not be effective for treatment of recrudescent malaria that develops after prior therapy with the combination. (nih.gov)
- The combination of atovaquone and proguanil is used to treat or prevent malaria. (drugs.com)
- The first combination to be evaluated is atovaquone and azithromycin. (clinicaltrials.gov)
- Resistant organisms did not emerge in hamsters treated with the combination of atovaquone and azithromycin. (ajtmh.org)
- The combination of atovaquone and azithromycin has the advantage of less risk of cardiac side effects compared to other potential COVID-19 treatments. (tgen.org)
- Laboratory modeling suggests that atovaquone may be an active drug in the treatment of COVID-19 and its combination with azithromycin, studied in the rare infectious disease babesiosis, makes this an intriguing combination to study in COVID-19. (tgen.org)
- however, there was a loss of synergy against atovaquone-resistant strain NGATV01 isolated after Malarone (the combination of atovaquone and proguanil) treatment failure. (asm.org)
- In the search for effective combination regimens, Malarone (the combination of atovaquone and proguanil), LapDap (the combination of chlorproguanil and dapsone), and Coartem (the combination of artemether and lumefantrine) have recently become available or are in development. (asm.org)
- In laboratory modelling, atovaquone was indicated to be an active drug for Covid-19 while its combination drug, azithromycin, has been studied in the rare infectious disease babesiosis. (clinicaltrialsarena.com)
- Because data are available about safe administration of quinine plus clindamycin during pregnancy, this drug combination, rather than atovaquone (plus azithromycin), generally is recommended for treatment of symptomatic babesiosis during pregnancy, unless the preferred medications are not available or tolerated. (cdc.gov)
- This medicine is a combination of atovaquone and proguanil marketed under the brand name Malarone that is used to treat the red blood cell infection Malaria, which is typically transmitted from host to host by biting insects. (healthery.com)
Effects of atovaquone2
Treated with proguanil1
- We analyzed parasite cultures treated with proguanil and atovaquone and, against the dogma of a human liver being necessary to create cycloguanil, observed low quantities of cycloguanil. (washington.edu)
Allergic to atovaquone1
- You should not use this medicine if you are allergic to atovaquone or proguanil. (rexhealth.com)
Effectiveness of atovaquone1
- Read user comments about the side effects, benefits, and effectiveness of atovaquone oral. (webmd.com)
Bioavailability of atovaquone2
- Atovaquone too has a quinine group and thus, it can mimic ubiquone and binds selectively to the Q0 site of parasitic mitochondria thereby block the parasitic mitochondrial respiration (Ridley R G 2002). (ipl.org)
- RESULTS: A strong and previously undescribed inhibition of BCRP-mediated transport by atovaquone with a 50% inhibitory concentration (IC50) of 0.23 muM (95% CI 0.17-0.29 muM) and inhibition of P-gp-mediated transport by quinine with an IC50 of 6.8 muM (95% CI 5.9-7.8 muM) was observed. (ru.nl)
- Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. (wikipedia.org)
- As these fungi require zinc for fungal growth, we examined the effect of atovaquone, a ubiquinone analog that disrupts zinc homeostasis, on fungal growth in vitro and in vivo. (arvojournals.org)
- Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. (drugbank.com)
- Its inhibitory effect being comparable to ubiquinone, atovaquone can act by selectively affecting mitochondrial electron transport and parallel processes such as ATP and pyrimidine biosynthesis in atovaquone-responsive parasites. (drugbank.com)
- Atovaquone is a ubiquinone analogue, and decreases the OCR by inhibiting mitochondrial complex III. (ox.ac.uk)
- Is atovaquone-proguanil-oral available as a generic drug? (medicinenet.com)
- MEPRON (atovaquone) is a quinone antimicrobial drug for oral administration. (rxlist.com)
- Atovaquone / proguanil is in the drug class antimalarial combinations . (drugs.com)
- Using a computational strategy to identify compounds opposing the gene expression signature of STAT3, we discovered atovaquone (Mepron), an antimicrobial approved by the US Food and Drug Administration, to be a potent STAT3 inhibitor. (bloodjournal.org)
- Organisms obtained from recrudescent animals, when inoculated into uninfected animals, proved to be unresponsive to atovaquone therapy, suggesting the emergence of drug resistance. (ajtmh.org)
- Moreover, the plasma pharmacokinetic profile of [ 14 C]atovaquone total radiocarbon is comparable to that observed with unlabeled parent drug, which confirms the absence of circulating metabolites. (aspetjournals.org)
- Proguanil and atovaquone drug synergy was evaluated with added consideration of DHFR localization involvement. (washington.edu)
- Even with widespread resistance to antimalarials based on DHFR inhibitors, the modern antimalarial drug Malarone® combines atovaquone-based inhibition of the electron transport chain pathway with proguanil/cycloguanil-based inhibition of DHFR and the folate cycle. (washington.edu)
- After proguanil was added to atovaquone a 98.7% cure rate was achieved, even in regions where DHFR-based drug resistance phenotypes were well established. (washington.edu)
- There is no significant risk for myelosuppression associated with atovaquone, making this drug a beneficial therapeutic agent for recipients of bone marrow transplantation. (drugbank.com)
- Because the efficacy of TMP-SMZ for treatment of bacterial infections is limited, it is sometimes poorly tolerated, and there is risk of emergence of drug-resistant strains associated with widespread use, we evaluated a regimen that included atovaquone and azithromycin. (oup.com)
- atovaquone/proguanil is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
- Anesthesia Central , anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109581/all/atovaquone_proguanil. (unboundmedicine.com)
- A shut atovaquone proguanil kaufen wrongdoing is reduced, low whole number cut off anesthetic,after drug store online canada skiagraphs govern unsuccessful a prodigious fracture. (4wardassociates.com)
- Of these, 289 were still taking the study-supplied dapsone or atovaquone, 214 were taking the originally prescribed drug and 75 had switched to a different treatment. (aafp.org)
- Atovaquone is used to prevent and treat Pneumocystis jiroveci pneumonia (PCP) in adults and children 13 years of age and older who cannot tolerate other medicines, such as trimethoprim-sulfamethoxazole. (odakeczane.com)
Hematopoietic stem cell trans1
- We describe a case of breakthrough cerebral toxoplasmosis during atovaquone therapy in a child who was intolerant of conventional prophylactic regimens after hematopoietic stem cell transplantation. (ovid.com)
- Dietary fat taken with atovaquone increases the rate and extent of absorption, increasing AUC 2 to 3 times and Cmax 5 times over fasting. (nih.gov)
- High-affinity human serum albumin (HSA) binding of the C3-substituted antimalarial 2-hydroxy-1,4-naphthoquinone derivative atovaquone (ATQ) has been demonstrated and studied by circular dichroism (CD), UV/VIS absorption, fluorescence spectroscopy and affinity chromatography methods. (rsc.org)
- 1- to examine the effect of food on atovaquone absorption 2- to examine whether the effect of food could be accounted for by fat content of the meal 3- to examine the absorption from an oily vehicle 4- to assess the contribution of native bile to the increase in absorption observed with food and fat 5- to examine the extent of uptake into chylomicrons. (tripod.com)
- A randomized, double-blind, placebo-controlled trial was designed to determine whether atovaquone-azithromycin had equivalent efficacy to TMP-SMZ for the prevention of serious bacterial infections and to compare the long-term tolerance, PCP breakthrough rates, and nonserious bacterial infection rates among HIV-infected children aged 3 months to 19 years. (oup.com)
- We conclude that, in HIV-infected children, atovaquone-azithromycin is as effective as TMP-SMZ for the prevention of serious bacterial infections and is similarly tolerated. (oup.com)
- The authors believe that clarithromycin and atovaquone may constitute valid alternatives for the treatment of cerebral toxoplasmosis. (unboundmedicine.com)
- We propose that atovaquone and diclazuril synergistically protect against fetal-maternal toxoplasmosis. (scirp.org)
- Conclusions: This is the first report describing combined atovaquone and diclazuril therapy a) to be safe in pregnancy, b) to exert novel synergistic effects, and c) to protect dams and their nested fetuses against adverse effects of severe toxoplasmosis. (scirp.org)
- Atovaquone also has been shown to have good in vitro activity against Toxoplasma gondii . (drugbank.com)
- Atovaquone shows anticancer efficacy in vitro, in vivo, and in a retrospective study of AML patient outcomes after atovaquone treatment. (bloodjournal.org)
- We became involved in the treatment of several cases of babesiosis in which atovaquone was used to treat this infection. (ajtmh.org)
- Atovaquone (100 mg/kg/day) and atovaquone (100 mg/kg/day) with azithromycin (150 mg/kg/day) were effective agents for the treatment of experimental babesiosis in hamsters. (ajtmh.org)
- Furthermore, mitochondrial potential and ATP production were reduced in both Aspergillus and Fusarium following atovaquone treatment. (arvojournals.org)
- The cycloguanil resistance conferred by the rescue plasmid did not translate into resistance to proguanil and atovaquone treatment with a transfection construct that did not localize as the native DHFR-TS. (washington.edu)
- Early studies with atovaquone alone for treatment of malaria demonstrated good initial control of parasitemia but an unacceptable rate of recrudescent parasitemia. (semanticscholar.org)
- Atovaquone is not a kinase inhibitor but instead rapidly and specifically downregulates cell-surface expression of glycoprotein 130, which is required for STAT3 activation in multiple contexts. (bloodjournal.org)
- These findings establish atovaquone as a novel, clinically accessible STAT3 inhibitor with evidence of anticancer efficacy in both animal models and humans. (bloodjournal.org)
- Hepatocyte uptake of atovaquone was not impaired by OATP and OCT inhibitor cocktail (rifamycin and imipramine). (aspetjournals.org)
- Even after correcting for apparent nonspecific binding and incomplete solubility in bile, atovaquone is still concentrated ≥100-fold in bile, consistent with active biliary excretion. (aspetjournals.org)
- In the present study, we rule out the involvement of major known basolateral uptake and bile canalicular efflux transporters in the hepatic uptake and biliary excretion of atovaquone. (aspetjournals.org)
- Atovaquone antagonized by tetracycline, metoclopramide. (psychiatryadvisor.com)