Azasteroids: Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with nitrogen atoms.Sex Reassignment Surgery: Surgical treatments used to change the physiological sexual characteristics of an individual.Transsexualism: Severe gender dysphoria, coupled with a persistent desire for the physical characteristics and social roles that connote the opposite biological sex. (APA, DSM-IV, 1994)Urology: A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.Andrology: A scientific or medical discipline concerning the study of male reproductive biology, diseases of the male genital organs, and male infertility. Major areas of interest include ENDOCRINOLOGY; SPERMATOGENESIS; semen analysis; FERTILIZATION; CONTRACEPTION; and CRYOPRESERVATION.Access to Information: Individual's rights to obtain and use information collected or generated by others.Urologic Neoplasms: Tumors or cancer of the URINARY TRACT in either the male or the female.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Carboxymethylcellulose Sodium: A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.Metals, Alkaline Earth: Metals that constitute the group 2 (formerly group IIa) of the periodic table.Calcium Sulfate: A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.Cellulose: A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Cellulase: An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, lichenin, and cereal beta-glucans.Methylcellulose: Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.Steroids, Heterocyclic: Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with non-carbon atoms.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Carbon: A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.Gonadal Steroid Hormones: Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.Receptors, Steroid: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Azasteroids are a type of steroid derivatives which have nitrogen atoms replaced at various positions for one of the carbon ... 4-en-3-one function and a lipophilic 17β-side chain with one or more oxygen atoms. The main problems for 4-azasteroids is the ... atoms in the steroid ring system. Two 4-azasteroids, finasteride and dutasteride are marketed as 5-ARIs. Finasteride (Proscar ... the substitution of one carbon atom of the rings of the steroids by a heteroatom such as nitrogen thereby forming azasteroids. ...
Two azasteroids, finasteride and dutasteride, are used clinically as 5α-reductase inhibitors. Some of the 6-azasteroids may ... An azasteroid is a type of steroid derivative which has one of the carbon atoms in the steroid ring system replaced by a ... "6-Azasteroids: Potent dual inhibitors of human type 1 and 2 steroid 5.alpha.-reductase". Journal of Medicinal Chemistry. 36 (26 ... "6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha.-Reductase and Human Adrenal 3. ...
While the above figure gives examples of 4-aza steroids, 6-aza steroids have also been developed by GSK, although none of these ... Sometimes a number between hyphens is inserted before it to state which atom the nitrogen atom replaces. It arose by shortening ... is used in organic chemistry to form names of organic compounds where a carbon atom is replaced by a nitrogen atom. The related ... term "deaza-" refers to when a nitrogen is removed and, usually, a carbon atom is put in its place. ...
Azasteroids are a type of steroid derivatives which have nitrogen atoms replaced at various positions for one of the carbon ... 4-en-3-one function and a lipophilic 17β-side chain with one or more oxygen atoms. The main problems for 4-azasteroids is the ... atoms in the steroid ring system. Two 4-azasteroids, finasteride and dutasteride are marketed as 5-ARIs. Finasteride (Proscar ... the substitution of one carbon atom of the rings of the steroids by a heteroatom such as nitrogen thereby forming azasteroids. ...
Two azasteroids, finasteride and dutasteride, are used clinically as 5α-reductase inhibitors. Some of the 6-azasteroids may ... An azasteroid is a type of steroid derivative which has one of the carbon atoms in the steroid ring system replaced by a ... "6-Azasteroids: Potent dual inhibitors of human type 1 and 2 steroid 5.alpha.-reductase". Journal of Medicinal Chemistry. 36 (26 ... "6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha.-Reductase and Human Adrenal 3. ...
2) 6-Azasteroids (e.g., GIlS7669X) have a heterocyclic B ring (nitrogen atom at position 6) and a Δ4,5 bond in the A ring and ... 1) 4-Azasteroids: the 3-oxo, 5-alpha steroids with a nitrogen atom at position 4 have been the most extensively studied. ... 3) 10-azasteroids, for example, AS97004, are competitive 5α-RI with a similar mechanism of action to 6-azasteroids [9]. ... 3-azasteroids, 19-nor-10-azasteroids, and diazasteroids [9].. 8.2. Nonsteroidal Inhibitors [9, 30, 46]. Several pharmaceutical ...
Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with nitrogen atoms. ... Azasteroids. Subscribe to New Research on Azasteroids Steroidal compounds in which one or more carbon atoms in the steroid ring ...
Keywords:enzyme, hydroxysteroid dehydrogenase, 4-aza-steroids, sar, inhibitors, steroidogenesis. Abstract: We present the SAR ... 4-methyl-4-aza-5α-androstan-3-one compounds bearing a side chain containing 7 to 10 carbon atoms when tested at 0.3 μM. ... 4-methyl-4-aza-5α-androstan-3-one compounds bearing a side chain containing 7 to 10 carbon atoms when tested at 0.3 μM. ...
125000004435 hydrogen atoms Chemical group data:image/svg+xml;base64,PD94bWwgdmVyc2lvbj0nMS4wJyBlbmNvZGluZz0naXNvLTg4NTktMSc/ ... US5359071A - 15-substituted 4-azasteroids - Google Patents. 15-substituted 4-azasteroids Download PDF Info. Publication number ... 125000004432 carbon atoms Chemical group data:image/svg+xml;base64,PD94bWwgdmVyc2lvbj0nMS4wJyBlbmNvZGluZz0naXNvLTg4NTktMSc/ ...
... hydrogen atom (H), cyano-group; R4 and R10 mean hydrogen atom or methyl group; both R1 and R2 represent hydrogen atom and form ... SUBSTANCE: invention describes novel halogen- and pseudohalogen-substituted 17-methylene-4-azasteroids of the general formula ( ... consisting of carbon atom or nitrogen atom; when A represents carbon atom, R1 represents C1-C6-alkoxyl; R2 represents cyano; ... containing 1-4 nitrogen atoms and optionally additionally containing an oxygen or sulphur atom or containing an oxygen atom as ...
... hydrogen atom (H), cyano-group; R4 and R10 mean hydrogen atom or methyl group; both R1 and R2 represent hydrogen atom and form ... SUBSTANCE: invention describes novel halogen- and pseudohalogen-substituted 17-methylene-4-azasteroids of the general formula ( ... wherein each R20 and R20a means independently fluorine, chlorine, bromine atom, (C1-C4)-alkyl, ... Y means hydrogen atom (H); A means -O- or -S-; R1 means (C1-C4)-alkyl, (C2-C4)-olefin, (C1-C6)-acyl, (C3-C7)-cycloalkylcarbonyl ...
... or B-ring by an hetero-atom, led to the discovery of potent inhibitors of 5aR-2 such as the 4-azasteroids, 6-azasteroids, 10- ... 225Ac has a 10-d half-life and decays by a emission through three atoms, each of which also emits an a particle. In vitro, ... Substitution of one carbon atom at the A- ... azasteroids, as well as steroidal carboxylic acid inhibitors ... emerged from a family of 6-azasteroids through modification of the steroidal struc Novel substituted benzoylbenzoic acids and ...
atom which is part of one ring and has two ring carbon-carbon bonds, or. one monovalent substituent attached to a carbon atom ... substituted with one or more halogen atoms.. R9 represents hydrogen or F.. q" represents a carbonyl oxygen atom or is R11"1 and ... In the examples 1 to 3 four carbon and three oxygen atoms or eight carbon atoms respectively are lost compared to the loss of ... Process for the preparation of 4-azasteroids. The invention relates to a process for the preparation of 4-azasteroids of the ...
Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with non-carbon atoms. ... Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with non-carbon atoms. ... Azasteroids: 1. *1,6-dithiabenz(3,4)estra-3,5(10),8,14-tetraen-17-one ...
I know that theres a ligand efficiency argument to be made against them - all that weight, for one atom - but there are times ... When I wrote here about unknown compounds, using aza-steroids as examples, I apparently wasnt thinking far enough afield. I ...
M. S. Ahmad, Shafiullah, and M. Mushfiq, "Azasteroids from 3α, 5α-Cyclocholestan-6-one and 3β-bromo-5α-cholestan-6-one," ... M. Martin-Smith and M. F. Sugrume, "Biological activity in steroids possessing nitrogen atoms: recent advances," The Journal of ... A. Guarna, E. G. Occhiato, F. Machetti, and D. Scarpi, "A concise route to 19-nor-10-azasteroids, a new class of steroid 5α- ... 20-22]. During the last decade, a number of azasteroids have been synthesized as 5α-reductase inhibitors [23-27]. Guarna and ...
steroids for sale Based on molecular properties which have been measured at the atom positions, a continuous field based ... anabolic steroids Our attempts to synthesise ring junction azasteroids and the problems that we encountered are then discussed. ... Subsequent sections describe the disconnection of azasteroids where nitrogen is part of the body of the ring and the synthetic ...
  • In saturated rigid ring structures like steroids, ring carbon atoms have either two monovalent substituents or one bivalent substituent attached to a carbon atom which is part of one ring and has two ring carbon-carbon bonds, or one monovalent substituent attached to a carbon atom which is part of two condensed rings and has three ring carbon-carbon bonds. (allindianpatents.com)
  • Figure Remove)O' a substituent R"~', wherein n denotes the number of the respective carbon atom C" which is "below" the other substituent will be identified as being in the a-position (e.g. (allindianpatents.com)
  • R1"1 or a-R1) and its bond to the carbon atom Cn is represented by a broken, dotted or dashed line. (allindianpatents.com)
  • Accordingly, the substituent Rn~2 attached "above" the other (R"~') is identified as being in the p-position and its bond to the carbon atom Cn is represented by a heavy or bold line or a solid wedge. (allindianpatents.com)