Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.Sulfanilamides: Compounds based on 4-aminobenzenesulfonamide. The '-anil-' part of the name refers to aniline.Phenylurea Compounds: Compounds that include the amino-N-phenylamide structure.Intermediate Filament Proteins: Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.Bromine: A halogen with the atomic symbol Br, atomic number 36, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.Urea: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.Cycloaddition Reaction: Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.Heptanes: Seven-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.Equipment and Supplies: Expendable and nonexpendable equipment, supplies, apparatus, and instruments that are used in diagnostic, surgical, therapeutic, scientific, and experimental procedures.Device Approval: Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.Equipment Safety: Freedom of equipment from actual or potential hazards.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Medical Device Legislation: Laws and regulations pertaining to devices used in medicine, proposed for enactment, or enacted by a legislative body.Alkynes: Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.Dry Powder Inhalers: A device that delivers medication to the lungs in the form of a dry powder.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Calixarenes: Phenolic metacyclophanes derived from condensation of PHENOLS and ALDEHYDES. The name derives from the vase-like molecular structures. A bracketed [n] indicates the number of aromatic rings.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Diynes: Compounds with two triple bonds. Some of them are CYTOTOXINS.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Martial Arts: Activities in which participants learn self-defense mainly through the use of hand-to-hand combat. Judo involves throwing an opponent to the ground while karate (which includes kung fu and tae kwon do) involves kicking and punching an opponent.Silver: Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.HydrazinesSilver Nitrate: A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Kinetics: The rate dynamics in chemical or physical systems.Silver Compounds: Inorganic compounds that contain silver as an integral part of the molecule.Receptors, Nicotinic: One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.Torpedo: A genus of the Torpedinidae family consisting of several species. Members of this family have powerful electric organs and are commonly called electric rays.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Affinity Labels: Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids.Photoaffinity Labels: Biologically active molecules which are covalently bound to the enzymes or binding proteins normally acting on them. Binding occurs due to activation of the label by ultraviolet light. These labels are used primarily to identify binding sites on proteins.BerlinLecture NotesScotlandPublications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Epoxide Hydrolases: Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.Adamantane: A tricyclo bridged hydrocarbon.8,11,14-Eicosatrienoic Acid: A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.Benzoates: Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.Lauric Acids: 12-Carbon saturated monocarboxylic acids.Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.
Isoxazole, an analog with the nitrogen atom in position 2. Imidazole, an analog with the oxygen replaced by a nitrogen. ... Pyrrole, an analog without the oxygen atom. Furan, an analog without the nitrogen atom. Oxazoline, which has one double bond ... Oxazoles are not as abundant in biomolecules as the related thiazoles with oxygen replaced by a sulfur atom. Deprotonation of ...
Imidazole is an analog of pyrazole with two non-adjacent nitrogen atoms. In isoxazole, another analog, the nitrogen atom in ... It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms. Pyrazole is a ... Pyrazoles are also a class of compounds that have the ring C3N2 with adjacent nitrogen atoms. Notable drugs containing a ...
... is an azole with an oxygen atom next to the nitrogen. It is also the class of compounds containing this ring. ... Examples of AAS containing the isoxazole ring include danazol & androisoxazole. Oxazole, an analog with the nitrogen atom in ... Isoxazole rings are found in some natural products, such as ibotenic acid and muscimol[citation needed]. Isoxazoles also form ... Furan, an analog without the nitrogen atom. Simple aromatic rings Zoltewicz, J. A. & Deady, L. W. Quaternization of ...
Synthetic Route for Inserting a Carbon Atom Between the Atoms of a Double Bond". Journal of the American Chemical Society. 80 ( ... In the case of oxazole and isoxazole, the lone pairs contributed to the aromatic sextet come from the occupied pz orbital of ... In the diagram below, the nitrogen atom in pyridine is markedly more electronegative than nitrogen atom in indole, as indicated ... with all the contributing atoms in the same plane Contributing atoms arranged in one or more rings A number of π delocalized ...
It is an isomer of the more common compounds benzoxazole and benzisoxazole, with the oxygen atom being located in the 3- ... Anthranil (2,1-benzisoxazole) is an organic compound with a molecular formula C7H5NO, which features a fused benzene-isoxazole ...
Pyrrole, an analog without the oxygen atom. Furan, an analog without the nitrogen atom. Oxazoline, which has only one double ... In an isoxazolidine nitrogen and oxygen occupy positions 1 and 2 in the ring: It is the saturated relative of Isoxazole. ...
The most nucleophilic atom is usually, but not always, the most electron-rich atom. In 1,3-dipolar cycloadditions, identity of ... whereas the reaction with an alkyne yields the isoxazole. Both isoxazolines and isoxazoles can be cleaved by hydrogenation to ... In general, the atom that carries the largest orbital coefficient in the HOMO acts as the nucleophile, whereas that in the LUMO ... Both types of 1,3-dipoles share four electrons in the π-system over three atoms. The allyl-type is bent whereas the propargyl/ ...
... s are a class of five-membered heterocyclic compounds containing a nitrogen atom and at least one other non-carbon atom (i ... Nitrogen only Imidazole Pyrazole 1,2,3-Triazole 1,2,4-Triazole Tetrazole Pentazole N,O compounds Oxazole Isoxazole 1,2,3- ... Names of azoles maintain the prefix upon reduction (e.g., pyrazoline, pyrazolidine). The numbering of ring atoms in azoles ...
As ylides, they possess a negative charge and a positive charge on adjacent atoms. As a 1,3-dipole, several resonance ... by the photochemical ring opening of azirines or isoxazoles and by dehydrochlorination of imidoyl chlorides. The latter is the ... "Capture of an Elusive Nitrile Ylide as an Intermediate in Isoxazole-Oxazole Photoisomerization". J. Org. Chem. 78 (21): 10657- ...
Thiazoles and isothiazoles contain a sulfur and a nitrogen atom in the ring. Dithiolanes have two sulfur atoms. ... Isoxazole Nitrogen/sulfur Thiazolidine. Isothiazolidine Thiazole (Thiazoline). Isothiazole Oxygen/oxygen Dioxolane Sulfur/ ... A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of ... Heterocycles with three atoms in the ring are more reactive because of ring strain. Those containing one heteroatom are, in ...
Quinuclidine has a similar structure, with one of the nitrogen atoms replaced by a carbon atom. The pKa of [HDABCO]+ (the ... as an Efficient Reagent for the Synthesis of Isoxazole Derivatives from Primary Nitro Compounds and Dipolarophiles: The Role of ...
... s are a class of naturally occurring organic compounds that mostly contain basic nitrogen atoms. This group also ... Those originate from the amino acid phenylalanine, but acquire their nitrogen atom not from the amino acid but through ... Isoxazole derivatives Ibotenic acid → Muscimol Ibotenic acid, Muscimol Thiazole derivatives[107] 1-Deoxy-D-xylulose 5-phosphate ...
In a special group of compounds, an aryl carbon atom acts as a bridge between two gold atoms. One such compound, (MesAu)5,is ... catalyzed one-pot synthesis of isoxazoles from terminal alkynes and nitric acid". Journal of the American Chemical Society. 115 ...
... isoxazole) Androstanolone (17ß-hydroxy-5α-androstan-3-one) Androstenediol (androst-5-ene-3ß,17ß-diol) Bolandiol (estr-4-ene-3ß, ... Any substance that has a quinolin-8-yl 1H-indole-3-carboxylate structure with substitution at the nitrogen atom of the indole ... Any substance that has a 3-benzoylindole structure with substitution at the nitrogen atom of the indole ring, whether or not ... or substituted at two adjacent carbon atoms of the benzene ring which results in the formation of a furan, dihydrofuran, pyran ...
Isoxazole, an analog with the nitrogen atom in position 2. Imidazole, an analog with the oxygen replaced by a nitrogen. ... Pyrrole, an analog without the oxygen atom. Furan, an analog without the nitrogen atom. Oxazoline, which has one double bond ... Oxazoles are not as abundant in biomolecules as the related thiazoles with oxygen replaced by a sulfur atom. Deprotonation of ...
Imidazole is an analog of pyrazole with two non-adjacent nitrogen atoms. In isoxazole, another analog, the nitrogen atom in ... It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms. Pyrazole is a ... Pyrazoles are also a class of compounds that have the ring C3N2 with adjacent nitrogen atoms. Notable drugs containing a ...
PART III: THE EMPLOYMENT OF ISOXAZOLES AS INTERMEDIATES IN THE SYNTHESIS OF PRODIGIOSIN SHEU, JENQ-TSONG (1975) ... KINETIC STUDIES OF SOME GAS PHASE CHEMICAL REACTIONS: I. HYDROGEN ATOM + HYDROGEN-CHLORIDE ---, HYDROGEN MOLECULE + CHLORINE ...
b) Brand, J.P.; Fernández González, D.; Nicolai, S.; Waser, J. Benziodoxole-based hypervalent iodine reagents for atom-transfer ... a) Sheng, S.R.; Liu, X.L. Xu, Q.; Song, C.S. One-pot synthesis of 3-substituted isoxazoles from phenyl vinylic selenide. ... Raihan, M.J.; Kavala, V.; Kuo, C.W.; Raju, B.R.; Yao, C.F. On-watersynthesis of chromeno-isoxazoles mediated by [hydroxy ( ... Jawalekar, A.M.; Reubsaet, E.; Rutjes, F.P.J.T.; van Delft, F.L. Synthesis of isoxazoles by hypervalent iodine-induced ...
4.10.4. Five-Membered Ring Heterocycles with Two Hetero Atoms: Imidazoles, Benzimidazoles, 1H-pyrazoles, Oxazoles, Isoxazoles, ... 5.11.7. Oxazoles, Isoxazoles, Oxazolidines, Thiazoles, 1H-pyrazoles, 1H-indazoles, Benzoxazoles, and Benzothiazoles / 234 ...
C07D261/14-Nitrogen atoms * C07D261/16-Benzene-sulphonamido isoxazoles Description. United States Patent M 3,300,488 N,N-BIS[4 ... members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms ... Isoxazole derivatives of sulfanilamide Patent Citations (1). * Cited by examiner, † Cited by third party. Publication number. ... Isoxazole derivatives of sulfanilamide Cited By (36). * Cited by examiner, † Cited by third party. Publication number. Priority ...
... or 7-membered nonaromatic ring containing at least one nitrogen atom which is bonded to an atom which is not part of the ... and isoxazole. ... of the invention which have one or more asymmetric carbon atoms ... The term "lower alkyl" as used herein referes to a branched or straight chain alkyl groups comprising one to ten carbon atoms, ... The term "cycloalkyl" as used herein refers to an alicyclic group comprising from 3 to 7 carbon atoms including, but not ...
"Alkyl-S(O).sub.q" refers to an alkyl group linked to a sulfur atom. The sulfur atom is attached 0-2 oxygen atom(s) depending on ... Examples of heteroaromatic groups include: pyridine, pyrimidinyl, pyrrole, pyridazine, isoxazole, indole, or imidazole. " ... "Cycloalkyl-S(O).sub.q" refers to a cycloalkyl group linked to a sulfur atom. The sulfur atom is attached to 0-2 oxygen atoms(s ... In the compounds described herein, the atoms may exhibit their natural isotopic abundances, or one or more of the atoms may be ...
Isoxazole is five-membered ring with three carbon atoms, and an oxygen atom next to a nitrogen atom.. Kingdom. Organic ... These are aromatic compounds containing a benzene ring fused to an isoxazole ring. ... Isoxazoles / Heteroaromatic compounds / Oxacyclic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen ... Isoxazole / Monocyclic benzene moiety / Organic nitrogen compound / Organic oxygen compound / Organonitrogen compound / ...
... isoxazole were studied for the case of Pummerer reaction product with oxidized sulfur atom, ethyl 6-trifluoromethyl-4,7а- ... isoxazole isoxazoline nitrile oxide thiopyran thiopyrano[3,4-d]isoxazole cleavage [3+2] cycloaddition Pummerer reaction ... The first representatives of the novel 4,7а-dihydro-3аН-thiopyrano[3,4-d]isoxazole heterocyclic system, containing an ester, ... The synthesis and properties of 6-trifluoromethyl-substituted thiopyrano[3,4-d]isoxazole derivatives. ...
The isoxazole ring and morpholine ring (the latter on the far right) are viewed side on. The amide substitution on the ... with the 2 hydroxyl group oxygen atoms colored red) binds deep into the base of the nucleotide binding pocket is clearly ... Again, the isoxazole ring amide projects out of the plane. Also clear in this representation is that the NVP-AUY922 molecule ... X-ray cocrystal structure of the clinically evaluated resorcylic isoxazole drug NVP-AUY922 bound to the N-terminal domain of ...
... isoxazoles with 2-bromo-propanamides has been developed. The azaoxyallyl cation intermediates are employed as C∼O 3-atom ... Ring opening [3 + 2] cyclization of azaoxyallyl cations with benzo[d]isoxazoles: Efficient access to 2-hydroxyaryl-oxazolines. ...
H atoms were placed at idealized positions and allowed to ride on their parent atoms with C-H distances in the range of 0.93 to ... For the biological and therapeutic importance of isoxazoles, see: Kang et al. (2000. ); Conti et al. (1998. ); Changtam et al. ... Primary atom site location: structure-invariant direct methods. Least-squares matrix: full. Secondary atom site location: ... For the biological and therapeutic importance of isoxazoles, see: Kang et al. (2000); Conti et al. (1998); Changtam et al. ( ...
... oxygen atom, or sulfur atom which is bonded to an atom which is not part of the heterocyclic ring.. The term "arylheterocyclic ... isoxazole and the like.. The term "heterocyclic ring" refers to any 3-, 4-, 5-, 6-, or 7-membered nonaromatic ring containing ... The term "lower alkyl" as used herein refers to branched or straight chain alkyl groups comprising one to ten carbon atoms, ... The term "cycloalkyl" as used herein refers to an alicyclic group comprising from about 3 to about 7 carbon atoms including, ...
Ra and Rb, Ra and Rc, or Ra and Rd may combine with the atoms to which they are bound to form an optionally substituted ... isoxazole; 1-Methyl-4-{4-[phenyl(3,3,5,5-tetramethylcyclohexylidene)methyl]phenyl}-1H-pyrazole; 4-{4-[(4-Fluorophenyl)(3,3,5,5- ... As used herein the term "spirocycle" describes a ring system that includes two rings that share a common atom. Examples of ... or Ra and Rd may combine with the atoms to which they are bound to form an optionally substituted heterocyclyl; and Re and Rf ...
In the compounds of generic Formula I, the atoms may exhibit their natural isotopic abundances, or one or more of the atoms may ... isoxazole, naphthyridine, oxadiazole, oxazole, phthalazine, pteridine, purine, pyran, pyrazine, pyrazole, pyridazine, pyridine ... As used herein, the term "heteroaryl" refers to groups having 5 to 14 ring atoms, preferably 5, 6, 9, or 10 ring atoms; having ... nitrogen atom on a pyridyl group) or sulfur atom it is referred to a N-oxide and sulfoxide group, respectively. ...
... an acyclic alkyl group in which one of the hydrogen atoms bonded to a carbon atom, typically a terminal or sp.sup.3 carbon atom ... isoxazole and pyrazine. [0034] "Heteroarylalkyl" by itself or as part of another substituent refers to an acyclic alkyl group ... R.sub.8 is hydrogen, alkyl substituted with one or more fluorine atoms or arylalkyl substituted with one or more fluorine atoms ... in which one of the hydrogen atoms bonded to a carbon atom, typically a terminal or sp.sup.3 carbon atom, is replaced with a ...
... a halogen atom (e.g., a chlorine atom, a bromine atom), a heterocyclic nucleus (e.g., a morpholynyl group, a piperidyl group), ... an isoxazole nucleus, an oxyindole nucleus, a barbituric acid nucleus or 2-thiobarbituric acid nucleus, a rhodanine nucleus (e. ... wherein R11 is a hydrogen atom, an aliphatic group (preferably, an alkyl group containing 1 to 20 carbon atoms, a cycloalkyl ... and including a substituent thereon, if any) generally has 1 to 20 carbon atoms, preferably 1 to 12 carbon atoms and an aryl ...
1984) Flash photolysis of isoxazole monitored by time-of-flight mass spectrometry. Int J Mass Spectrom Ion Process 60:203-212. ... 2010) Exploring the mechanisms of H atom loss in simple azoles: Ultraviolet photolysis of pyrazole and triazole. J Chem Phys ... 3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrrazol-4-yl)isoxazole. cpm. count per minute. dFBr. ... The 3,5-disubstituted isoxazole ring forms a reactive azirine intermediate upon irradiation at 313 nm or shorter wavelengths ( ...
Five-Membered Heterocyclic Compounds with Four Hetero-Atoms in the Ring. Sainsbury, M., 1964, Rodds Chemistry of Carbon ... Five-Membered Heterocyclic Compounds with Three Hetero-Atoms in the Ring. Sainsbury, M., 1964, Rodds Chemistry of Carbon ... Five-Membered Heterocyclic Compounds with Two Different Hetero-Atoms in the Ring. Sainsbury, M., 1964, Rodds Chemistry of ... Five-membered heterocyclic compounds with two nitrogen atoms in the ring. Theobald, R. S., 1964, Rodds Chemistry of Carbon ...
For example, L may have between about 1 and about 6 carbon atoms. In some embodiments, L has 4 carbon atoms. R′ may be a linear ... Representative heteroaromatic groups include pyrrole, furan, thiophene, imidazole, pyrazole, oxazole, isoxazole, thiazole, ... In some embodiments, R′ has 2 carbon atoms. In other embodiments, an R group may be present on more than one carbon atom. ... For example, the groups may contain between about 1 and about 10 carbon atoms, such as between about 1 and about 6 carbon atoms ...
... interrupted by 1 to 4 nitrogen atoms, which can be, for example, selected from furane, pyrrole, oxazole, oxadiazole, isoxazole ... X is an oxygen atom, a sulfur atom or a methylene group, ... X is an oxygen atom, a sulfur atom or a methylene group, ... a NH 2 -R 4 , NHR R 5 or NR R 5 R 6 group in which R , R 5 and R6, identical or different, represent a hydrogen atom or a ... refers to a saturated or unsaturated alkyl chain in which some hydrogen atoms are replaced by halogen atoms, such as fluorine, ...
"Alkenyl" refers to straight or branched hydrocarbyl groups having from 2 to 6 carbon atoms and preferably 2 to 4 carbon atoms ... isoxazole, phenoxazine, phenothiazine, imidazolidine, imidazoline, piperidine, piperazine, indoline, phthalimide, 1,2,3,4- ... refers to straight or branched monovalent hydrocarbyl groups having from 2 to 6 carbon atoms and preferably 2 to 3 carbon atoms ... refers to monovalent saturated aliphatic hydrocarbyl groups having from 1 to 10 carbon atoms and preferably 1 to 6 carbon atoms ...
S or O with the proviso that when the hetero atom is S or O, there is 1 hetero atom in the ring and when the hetero atom is N ... isoxazole, isothiazole, quinoline, isoquinoline, acridine, chromene, phenazine, phenoxazine, phenothiazine, triazine, ... S or O with the proviso that when the hetero atom is S or O, there is 1 hetero atom in the ring and when the hetero atoms is N ... or bicyclic heteroaryl rings each containing from 2 to 6 carbon atoms with 1 to 3 hetero atoms and the hetero atoms in each ...
"Arylalkyl" refers to an acyclic alkyl group in which one of the hydrogen atoms bonded to a carbon atom, typically a terminal or ... isoxazole, naphthyridine,oxadiazole, oxazole, perimidine, phenanthridine, phenanthroline, phenazine, phthalazine, pteridine, ... "Arylalkylene" refers to a divalent acyclic alkyl group in which one of the hydrogen atoms bonded to a carbon atom, typically a ... "Aryl" refers to a monovalent aromatic hydrocarbon group derived by the removal of one hydrogen atom from a single carbon atom ...
  • Regio- and stereoselective [3 + cycloaddition reaction: access to isoxazole-dispirobisoxindoles featuring three contiguous stereocenters. (nih.gov)
  • 3. The compound according to claim 2, wherein said L is independently a single covalent bond or a covalent linkage having 1-20 nonhydrogen atoms selected from the group consisting of C, N, O, P, and S. (patentsencyclopedia.com)
  • at least one of D 1 , D 2 or --A-- containing an --SO 3 M group wherein M represents a hydrogen atom, an alkali metal or an ammonium group. (google.com)
  • If the speed of electron in the Bohr's first orbit of hydrogen atom be x, then what will be the speed of the electron in the 3rd orbit? (learnpick.com)
  • This planarity is also assisted by an intra-molecular C-H⋯O hydrogen bond between the phenyl ring and the carbonyl O atom. (iucr.org)
  • While the two hydrogen atoms at the N4- and N7- positions of the main chain form two H-bonds with the backbone carboxyl group of Gly106 (-O···HN, 1.69 Å, 146.5°) and the backbone carbonyl group of Thr80 (-O···HN, 1.85 Å, 160.0°), respectively. (nih.gov)
  • Positive allosteric modulators (PAMs) of nicotinic acetylcholine (ACh) receptors (nAChRs) have potential clinical applications in the treatment of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity, and 3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1 H -pyrrazol-4-yl)isoxazole (CMPI) has been identified as a PAM selective for neuronal nAChRs containing the α 4 subunit. (aspetjournals.org)
  • S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester ) approaches. (med-chemist.com)
  • TMHS is structurally similar to other ion channel regulatory subunits such as TARPs (transmembrane alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor regulatory proteins). (scoop.it)
  • Typically, the preferred non-photosensitive reducible silver source is a silver salt of a long chain aliphatic carboxylic acid having from 10 to 30 carbon atoms. (justia.com)
  • Tricyanovinylation occurs at either the N atom (aliphatic amines) (eq 1) or the para position (aromatic amines) (eq 2). (paperplane.io)
  • In previous work we have shown that it is possible to use muon spin spectroscopy to characterize H-atom-like muonium and muoniated free radicals formed in clathrate hydrates. (sfu.ca)
  • between your nitroxide and Asn109 along with the fairly weak electron thickness from the nitroxide air atom indicate that interaction is normally suboptimal. (cancer-ecosystem.com)
  • For the pyrimidines, this meant partially masking the reactive functionality through a relatively weak N-O bond in the form of an isoxazole ring. (nature.com)
  • Meanwhile, in the selective formation of 4-isoxazolines, hydride attack at the C5 atom may be obstructed by steric hindrance from the 5-aryl substituent. (kyushu-u.ac.jp)
  • Pyrazole itself reacts with potassium borohydride at high temperatures (~200 °C) to form a tridentate ligand known as Tp ligand: 3,5-Diphenyl-1H-pyrazole is produced when (E)-1,3-diphenylprop-2-en-1-one is reacted with hydrazine hydrate in the presence of elemental sulfur or sodium persulfate, or by using a hydrazone in which case an azine is produced as a by-product. (wikipedia.org)
  • Catalytic proximity requires an intimate physical association of these two materials so that when silver atoms (also known as silver specks, clusters, or nuclei) are generated by irradiation or light exposure of the photographic silver halide, those nuclei are able to catalyze the reduction of the reducible silver source within a catalytic sphere of influence around the silver specs. (justia.com)
  • This is accomplished by the reduction of silver ions which are in catalytic proximity to silver halide grains bearing the clusters of silver atoms (i.e., the latent image). (justia.com)