A nucleic acid sequence that contains an above average number of ADENINE and THYMINE bases.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A nucleic acid sequence that contains an above average number of GUANINE and CYTOSINE bases.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion.
An essential branched-chain amino acid important for hemoglobin formation.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Proteins found in any species of bacterium.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The relationships of groups of organisms as reflected by their genetic makeup.
Time period from 1801 through 1900 of the common era.
Time period from 1901 through 2000 of the common era.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The science devoted to the comparative study of man.
This discipline concerns the study of SEXUALITY, and the application of sexual knowledge such as sexual attitudes, psychology, and SEXUAL BEHAVIOR. Scope of application generally includes educational (SEX EDUCATION), clinical (SEX COUNSELING), and other settings.
Process of preserving a dead body to protect it from decay.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
A province of eastern Canada. Its capital is Quebec. The region belonged to France from 1627 to 1763 when it was lost to the British. The name is from the Algonquian quilibek meaning the place where waters narrow, referring to the gradually narrowing channel of the St. Lawrence or to the narrows of the river at Cape Diamond. (From Webster's New Geographical Dictionary, 1988, p993 & Room, Brewer's Dictionary of Names, 1992, p440)
Lengthy and continuous deprivation of food. (Stedman, 25th ed)
Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several thousand base pairs long. In humans there are about 45,000 CpG islands, mostly found at the 5' ends of genes. They are unmethylated except for those on the inactive X chromosome and some associated with imprinted genes.
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
A cell line derived from cultured tumor cells.
Tumors or cancer of the LUNG.
Established cell cultures that have the potential to propagate indefinitely.
Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
A plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).
A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.
A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.
Infections with bacteria of the genus STAPHYLOCOCCUS.
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS.
A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.
A sequential pattern of amino acids occurring more than once in the same protein sequence.
Failure or imperfection of vision at night or in dim light, with good vision only on bright days. (Dorland, 27th ed)
A pattern recognition receptor that forms heterodimers with other TOLL-LIKE RECEPTORS. It interacts with multiple ligands including PEPTIDOGLYCAN, bacterial LIPOPROTEINS, lipoarabinomannan, and a variety of PORINS.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and "classical" Kaposi sarcoma.
A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.
The type species of ROSEOLOVIRUS isolated from patients with AIDS and other LYMPHOPROLIFERATIVE DISORDERS. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter NK cell activity. HHV-6; (HBLV) antibodies are elevated in patients with AIDS, Sjogren's syndrome, sarcoidosis, chronic fatigue syndrome, and certain malignancies. HHV-6 is the cause of EXANTHEMA SUBITUM and has been implicated in encephalitis.
The type species of RHADINOVIRUS, in the subfamily GAMMAHERPESVIRINAE, isolated from squirrel monkeys. It produces malignant lymphomas (LYMPHOMA, MALIGNANT) in inoculated marmosets or owl monkeys.

Clustered adenine/thymine stretches are essential for function of a fission yeast replication origin. (1/203)

We have determined functional elements required for autonomous replication of the Schizosaccharomyces pombe ars2004 that acts as an intrinsic chromosomal replication origin. Internal deletion analysis of a 940-bp fragment (ars2004M) showed three regions, I to III, to be required for autonomously replicating sequence (ARS) activity. Eight-base-pair substitutions in the 40-bp region I, composed of arrays of adenines on a DNA strand, resulted in a great reduction of ARS activity. Substitutions of region I with synthetic sequences showed that no specific sequence but rather repeats of three or more consecutive adenines or thymines, without interruption by guanine or cytosine, are required for the ARS activity. The 65-bp region III contains 11 repeats of the AAAAT sequence, while the 165-bp region II has short adenine or thymine stretches and a guanine- and cytosine-rich region which enhances ARS activity. All three regions in ars2004M can be replaced with 40-bp poly(dA/dT) fragments without reduction of ARS activity. Although spacer regions in the ars2004M enhance ARS activity, all could be deleted when an 40-bp poly(dA/dT) fragment was added in place of region I. Our results suggest that the origin activity of fission yeast replicators depends on the number of adenine/thymine stretches, the extent of their clustering, and presence of certain replication-enhancing elements.  (+info)

The centromeric sister chromatid cohesion site directs Mcd1p binding to adjacent sequences. (2/203)

Cohesion between sister chromatids occurs along the length of chromosomes, where it plays essential roles in chromosome segregation. We show here that the centromere, a cis-acting cohesion factor, directs the binding of Mcd1p, a cohesin subunit, to at least 2 kb regions flanking centromeres in a sequence-independent manner. The centromere is essential for the maintenance as well as the establishment of this cohesin domain. The efficiency of Mcd1p binding within the cohesin domain is independent of the primary nucleotide sequence of the centromere-flanking DNA but correlates with high A + T DNA content. Thus, the function of centromeres in the cohesion of centromere-proximal regions may be analogous to that of enhancers, nucleating cohesin complex binding over an extended chromosomal domain of A + T-rich DNA.  (+info)

Nuclear protein binding at the beta-myosin heavy chain A/T-rich element is enriched following increased skeletal muscle activity. (3/203)

In adult mouse skeletal muscle, beta-myosin heavy chain (betaMyHC) gene expression is primarily restricted to slow-type I fibers but can be induced in fast-type II fibers by mechanical overload (MOV). Our previous transgenic analyses have delimited an 89-base pair (bp) MOV-responsive region (-293 to -205), and shown that mutation of the MCAT and C-rich elements within this region did not abolish betaMyHC transgene induction by MOV. In this study we describe an A/T-rich element (betaA/T-rich; -269 5'-GGAGATATTTTT-3' -258) located within this 89-bp region that, only under MOV conditions, revealed enriched binding as characterized by electrophoretic mobility shift assays and dimethyl sulfate and diethyl pyrocarbonate interference footprinting. Direct, competition, and supershift electrophoretic mobility shift assays revealed highly enriched specific binding activity at the betaA/T-rich element that was antigenically distinct from GATA-4, MEF2A-D, SRF, and Oct-1, nuclear proteins that were previously shown to bind A/T-rich elements. In vitro translated GATA-4, MEF2C, SRF, and Oct-1 bound to consensus GATA, MEF2, SRE, and Oct-1 elements, respectively, but not to the betaA/T-rich element. Two-dimensional UV cross-linking of the bromodeoxyuridine-substituted betaA/T-rich element with mechanically overloaded plantaris (MOV-P) nuclear extract detected two proteins (44 and 48 kDa). Our results indicate that the betaA/T-rich element may function in vivo as a betaMyHC MOV-inducible element during hypertrophy of adult skeletal muscle by binding two distinct proteins identified only in MOV-P nuclear extract.  (+info)

Sequence evolution in bacterial endosymbionts having extreme base compositions. (4/203)

A major limitation on ability to reconstruct bacterial evolution is the lack of dated ancestors that might be used to evaluate and calibrate molecular clocks. Vertically transmitted symbionts that have cospeciated with animal hosts offer a firm basis for calibrating sequence evolution in bacteria, since fossils of the hosts can be used to date divergence events. Sequences for a functionally diverse set of genes have been obtained for bacterial endosymbionts (Buchnera) from two pairs of aphid host species, each pair diverging 50-70 MYA. Using these dates and estimated numbers of Buchnera generations per year, we calculated rates of base substitution for neutral and selected sites of protein-coding genes and overall rates for rRNA genes. Buchnera shows homogeneity among loci with regard to synonymous rate. The Buchnera synonymous rate is about twice that for low-codon-bias genes of Escherichia coli-Salmonella typhimurium on an absolute timescale, and fourfold higher on a generational timescale. Nonsynonymous substitutions show a greater rate disparity in favor of Buchnera, a result consistent with a genomewide decrease in selection efficiency in Buchnera. Ratios of synonymous to nonsynonymous substitutions differ for the two pairs of Buchnera, indicating that selection efficiency varies among lineages. Like numerous other intracellular bacteria, such as Rickettsia and Wolbachia, Buchnera has accumulated amino acids with codons rich in A or T. Phylogenetic reconstruction of amino acid replacements indicates that replacements yielding increased A + T predominated early in the evolution of Buchnera, with the trend slowing or stopping during the last 50 Myr. This suggests that base composition in Buchnera has approached a limit enforced by selective constraint acting on protein function.  (+info)

Cell type-specific autoregulation of the Caudal-related homeobox gene Cdx-2/3. (5/203)

The caudal-related homeobox gene Cdx-2/3 is a critical "master" control gene in embryogenesis. Mice heterozygous for a null mutation in Cdx-2/3 exhibit multiple malfunctions including tail abnormalities, stunted growth, a homeotic shift in vertebrae, and the development of multiple intestinal adenomatous polyps, indicating that Cdx-2/3 is haplo-insufficient. In vitro studies have identified more than a half-dozen downstream target genes expressed in pancreatic and intestinal cells for this transcription factor. We have examined the transcriptional properties of the mouse Cdx-2/3 promoter. This promoter could be autoregulated in pancreatic and intestinal cells that express endogenous Cdx-2/3. In contrast, Cdx-2/3 transfection represses the Cdx-2/3 promoter in fibroblasts, which do not express endogenous Cdx-2/3. Since Cdx-2/3 activates proglucagon gene promoter in both pancreatic and intestinal cells and in fibroblasts, we suggest that some, yet to be identified, cell type-specific components are required for activating selected target gene promoters of Cdx-2/3, including the Cdx-2/3 promoter itself. Cdx-2/3 binds to the TATA box and another AT-rich motif, designated as DBS, within an evolutionarily conserved proximal element of the Cdx-2/3 promoter. The DBS motif is critical for the autoregulation, whereas the TATA box may act as an attenuating element for the autoregulatory loop. Finally, overexpression of Cdx-2/3 in a pancreatic cell line activated the expression of the endogenous Cdx-2/3. Taken together, our results indicate that the dose-dependent phenotype of Cdx-2/3 expression on its downstream targets in vivo could be regulated initially via a transcriptional network involving cell type-specific autoregulation of the Cdx-2/3 promoter.  (+info)

Host sequences flanking the human T-cell leukemia virus type 1 provirus in vivo. (6/203)

Human pathogenic retroviruses do not have common loci of integration. However, many factors, such as chromatin structure, transcriptional activity, DNA-protein interaction, CpG methylation, and nucleotide composition of the target sequence, may influence integration site selection. These features have been investigated by in vitro integration reactions or by infection of cell lines with recombinant retroviruses. Less is known about target choice for integration in vivo. The present study was conducted in order to assess the characteristics of cellular sequences targeted for human T-cell leukemia virus type 1 (HTLV-1) integration in vivo. Sequencing integration sites from >/=200 proviruses (19 kb of sequence) isolated from 29 infected individuals revealed that HTLV-1 integration is not random at the level of the nucleotide sequence. The virus was found to integrate in A/T-rich regions with a weak consensus sequence at positions within and without of the hexameric repeat generated during integration. These features were not associated with a preference for integration near active regions or repeat elements of the host chromosomes. Most or all of the regions of the genome appear to be accessible to HTLV-1 integration. As with integration in vitro, integration specificity in vivo seems to be determined by local features rather than by the accessibility of specific regions.  (+info)

Start sites of bidirectional DNA synthesis at the human lamin B2 origin. (7/203)

The initiation sites of bidirectional synthesis at the DNA replication origin located at the 3' end of the human lamin B2 gene were investigated. RNA-primed nascent DNA molecules were subjected to second-strand synthesis with appropriate primers, amplified by ligation-mediated polymerase chain reaction, and size fractionated. Evidence for precise start sites was obtained. Exploration of close to 1 kilobase, coupled to inhibition of Okazaki fragment synthesis, demonstrates that the leading strands initiate at precise nucleotides on either helix, overlapping by three base pairs, within the area bound to a protein complex possibly analogous to the prereplicative complex of yeast.  (+info)

AT-rich palindromes mediate the constitutional t(11;22) translocation. (8/203)

The constitutional t(11;22) translocation is the only known recurrent non-Robertsonian translocation in humans. Offspring are susceptible to der(22) syndrome, a severe congenital anomaly disorder caused by 3&rcolon;1 meiotic nondisjunction events. We previously localized the t(11;22) translocation breakpoint to a region on 22q11 within a low-copy repeat termed "LCR22" and within an AT-rich repeat on 11q23. The LCR22s are implicated in mediating different rearrangements on 22q11, leading to velocardiofacial syndrome/DiGeorge syndrome and cat-eye syndrome by homologous recombination mechanisms. The LCR22s contain AT-rich repetitive sequences, suggesting that such repeats may mediate the t(11;22) translocation. To determine the molecular basis of the translocation, we cloned and sequenced the t(11;22) breakpoint in the derivative 11 and 22 chromosomes in 13 unrelated carriers, including two de novo cases and der(22) syndrome offspring. We found that, in all cases examined, the reciprocal exchange occurred between similar AT-rich repeats on both chromosomes 11q23 and 22q11. To understand the mechanism, we examined the sequence of the breakpoint intervals in the derivative chromosomes and compared this with the deduced normal chromosomal sequence. A palindromic AT-rich sequence with a near-perfect hairpin could form, by intrastrand base-pairing, on the parental chromosomes. The sequence of the breakpoint junction in both derivatives indicates that the exchange events occurred at the center of symmetry of the palindromes, and this resulted in small, overlapping staggered deletions in this region among the different carriers. On the basis of previous studies performed in diverse organisms, we hypothesize that double-strand breaks may occur in the center of the palindrome, the tip of the putative hairpin, leading to illegitimate recombination events between similar AT-rich sequences on chromosomes 11 and 22, resulting in deletions and loss of the palindrome, which then could stabilize the DNA structure.  (+info)

The most abundant SSR tracts are the homopolymer repeats poly(dA).poly(dT) and poly(dG).poly(dC). Long (, 9 bp) tracts of both types are found at higher than expected frequencies in the non-coding regions of eukaryote genomes. This is particularly true for poly(dA).poly(dT) tracts in the AT-rich genomes [4]. The biological importance of SSR tracts has been clearly delineated. Homopolymer tracts, for example, can serve as protein binding signals, particularly as upstream promoter elements [5]. Also, long homopolymer tracts are spaced non-randomly in the genome of Dictyostelium discoideum, suggesting a preferential linker DNA location in the repeating nucleosome structure of this AT-rich organism [6]. While this restricted localization may be thermodynamically determined, the suggestion is that these tracts may serve some function determined by their accessibility in the linker DNA region between nucleosomes. The heteropolymer tracts are at least as important biologically. Dinucleotide repeats are ...
Purification of linearized AT-rich DNA for transfection - posted in Molecular Biology: Hi, I wanted to transfect linearized plasmid DNA. I am planning to digest around 200ug of DNA in a volume of around 200-300ul. The DNA is highly AT rich so I do not want to expose it to UV. Can I directly proceed to the phenol chloroform isoamyl alcohol step, without gel eluting the DNA?
Hopefully, you are aware that Infotechtion is able to provide Microsoft Compliance Workshops to help you understand the impact of M365 retention and security capabilities. We also have our own expanded version of this workshop as well that involves a deeper look at content not currently residing in M365. This can be scoped to include content from a variety of sources such as email systems, cloud environments, and most importantly shared drives. An expanded content assessment is intended to ide
TY - JOUR. T1 - DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation. AU - Kato, Takema. AU - Inagaki, Hidehito. AU - Tong, Maoqing. AU - Kogo, Hiroshi. AU - Ohye, Tamae. AU - Yamada, Kouji. AU - Tsutsumi, Makiko. AU - Emanuel, Beverly S.. AU - Kurahashi, Hiroki. PY - 2011/9/14. Y1 - 2011/9/14. N2 - Background. Cumulative evidence suggests that DNA secondary structures impact DNA replication, transcription and genomic rearrangements. One of the best studied examples is the recurrent constitutional t(11;22) in humans that is mediated by potentially cruciform-forming sequences at the breakpoints, palindromic AT-rich repeats (PATRRs). We previously demonstrated that polymorphisms of PATRR sequences affect the frequency of de novo t(11;22)s in sperm samples from normal healthy males. These studies were designed to determine whether PATRR polymorphisms affect DNA secondary structure, thus leading to variation in translocation frequency. ...
Looking for online definition of AT-rich interactive domain-containing protein 3C in the Medical Dictionary? AT-rich interactive domain-containing protein 3C explanation free. What is AT-rich interactive domain-containing protein 3C? Meaning of AT-rich interactive domain-containing protein 3C medical term. What does AT-rich interactive domain-containing protein 3C mean?
The assumption that USS arise by mutation rather than copying was first confirmed using alignments of H. influenzae proteins with distant homologues. Abundant USS-like repeats were found in all eight Pasteurellacean genomes; the repeat consensuses of species in the Hin subclade were identical to that of H. influenzae (AAGTGCGGT), whereas members of the Apl subclade shared the consensus ACAAGCGGT. All species USSs had the strong consensus and flanking AT-rich repeats of H. influenzae USSs. DNA uptake and competition experiments demonstrated that the Apl-type repeat is a true USS distinct from the Hin-type USS: A. pleuropneumoniae preferentially takes up DNA fragments containing the Apl-type USS over both H. influenzae and unrelated DNAs, and H. influenzae prefers its own USS over the Apl type ...
Edelmann L, Spiteri E, McCain N, Goldberg R, Pandita RK, Duong S, Fox J, Blumenthal D, Lalani SR, Shaffer LG, Morrow BE, A common breakpoint on 11q23 in carriers of the constitutional t(11;22) translocation. Am J Hum Genet65(6):1608-16 ...
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Looking for Fritillaria? Find out information about Fritillaria. The following article is from The Great Soviet Encyclopedia . It might be outdated or ideologically biased. , a genus of bulbous plants of the family... Explanation of Fritillaria
TY - JOUR. T1 - Molecular and clinical characterization of a recurrent cryptic unbalanced t(4q;18q) resulting in an 18q deletion and 4q duplication. AU - Horbinski, Craig. AU - Carter, Erika M.. AU - Heard, Patricia L.. AU - Sathanoori, Malini. AU - Hu, Jie. AU - Vockley, Jerry. AU - Gunn, Shelly. AU - Hale, Daniel. AU - Surti, Urvashi. AU - Cody, Jannine D.. PY - 2008/11/15. Y1 - 2008/11/15. N2 - Recurrent constitutional non-Robertsonian translocations are very rare. We present the third instance of cryptic, unbalanced translocation between 4q and 18q. This individual had an apparently normal karyotype; however, after subtelomere fluorescence in situ hybridization (FISH), he was found to have a cryptic unbalanced translocation between 4q and 18q [ish der(18)t(4;18)(q35;q23) (4qtel+, 18qtel-)]. Oligonucleotide array comparative genomic hybridization (aCGH) refined the breakpoints in this child and in the previously reported child and indicated that the breakpoints were within 20 kb of each ...
Tall showy stems of dark purple bobbing bells make this plant a real showpiece in your garden. Each raceme produces 30 small blooms on stems that can reach 3 tall. Blooms from May-June. 1 Bulb/pack Growing Instructions: Plant your fritillaria bulbs 6 deep in the fall in well-drained amended soil. Soil drainage is e
TY - CONF. T1 - Lagere nachttemperatuur tijdens opkweek Phalaenopsis. AU - Kromwijk, J.A.M.. AU - Campen, J.B.. AU - van Mourik, N.M.. AU - Schrama, P.M.M.. PY - 2010. Y1 - 2010. N2 - Resultaten van onderzoek bij 8 Phalaenopsiscultivars bij een lagere nachttemperatuur.. AB - Resultaten van onderzoek bij 8 Phalaenopsiscultivars bij een lagere nachttemperatuur.. KW - phalaenopsis. KW - orchidaceae. KW - cultivars. KW - temperatuur. KW - nachttemperatuur. KW - lage-energie teelt. KW - cultuurmethoden. KW - effecten. KW - plantenontwikkeling. KW - energiebesparing. KW - glastuinbouw. KW - phalaenopsis. KW - orchidaceae. KW - cultivars. KW - temperature. KW - night temperature. KW - low energy cultivation. KW - cultural methods. KW - effects. KW - plant development. KW - energy saving. KW - greenhouse horticulture. M3 - Poster. T2 - LTO-bijeenkomst Potorchidee. Y2 - 2 December 2010. ER - ...
If you are lucky enough to have a Phalaenopsis, you are about to enter the wonderful world of growing orchids! Phalaenopsis is one of the easiest orchids to grow in the home. If you follow a few basic requirements, these plants will reward you with several months of beautiful blooms. This product includes a free vase15
Single Stem Purple Phalaenopsis - PLANTS Single Stems Phalaenopsis Purple - Plants Size: H50-70cm Lifespan: 3-4 weeks • NOTE: When your flowers arrive in closed bud form, its okay. They just need a trim and some water, and theyll begin to bloom beaut
Author Summary Acquisition of DNA by horizontal gene transfer (HGT) significantly increases bacterial genetic variability. Relevant issues are the mechanisms that bacterial cells have evolved to efficiently integrate the newly acquired DNA into the host cell regulatory machinery. In Gram negative cells, the nucleoid associated protein H-NS has been shown to bind AT-rich sequences of HGT DNA and silence unwanted expression of these genes. This has led to consider H-NS as a
Do Phalaenopsis orchids like to be root bound? Although orchids enjoy being root-bound, theyll need to be repotted when the potting mix has broken down,
A new and distinct |i|Phalaenopsis |/i|cultivar named Suphal1401 which is characterized by small flowers with a large portion of the sepal and petal surfaces colored white and overlaid with both dar
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chai_z at wehi.edu.au wrote: : 1). Does the A,C rich sequence mean anything? : Zhonglin Chai Ive seen a lot of ACACACACAC and GTGTGTGTGT (pyrimidine-purine) repeats in non-coding DNA and there is a lot of literature about them. But sorry I dont have the references in front of me. Other than that, I cant help you. -- ******************************************************************** * Brian Foley * If we knew what we were doing * * Molecular Genetics Dept. * it wouldnt be called research * * University of Vermont ...
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Replication origins are considered important sites for understanding the molecular mechanisms involved in DNA replication. Many computational methods have been developed for predicting their locations in archaeal, bacterial and eukaryotic genomes. However, a prediction method designed for a particular kind of genomes might not work well for another. In this paper, we propose the AT excursion method, which is a score-based approach, to quantify local AT abundance in genomic sequences and use the identified high scoring segments for predicting replication origins. This method has the advantages of requiring no preset window size and having rigorous criteria to evaluate statistical significance of high scoring segments. We have evaluated the AT excursion method by checking its predictions against known replication origins in herpesviruses and comparing its performance with an existing base weighted score method (BWS1). Out of 43 known origins, 39 are predicted by either one or the other method and 26
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have ...
5121 Telomeres, centromeres, and other highly repetitive genomic regions are typically under-represented in shotgun libraries, and they are often absent from partial-digest BAC libraries. Accurate cloning of isolated fragments containing short tandem repeats, AT-rich DNA, or regions with strong secondary structure likewise can be difficult or impossible using conventional supercoiled plasmids. We have developed vectors and methods to alleviate these types of cloning bias. A transcription-free, linear plasmid was derived from the linear coliphage N15 for cloning into E.coli. The ends of the vector are free to rotate during replication, minimizing formation of secondary structures that are substrates for deletion or rearrangement. The pJAZZ linear vectors are shown to provide unprecedented ability to maintain regions of up to 30 kb that are unclonable in circular plasmids. Examples include regions of di-, tri-, and tetra-nucleotide repeats up to several kb, as well as highly AT-rich fragments of ...
Sometimes its the little things that make the big difference in a home setting. Just like our attention-grabbing white phalaenopsis orchid spray.
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Phalaenopsis orchids, commonly known as moth orchids, are prized for their delicate blooms, exotic appeal and wide availability that results from a relatively easy-to-grow nature, at least among ...
58 Phalaenopsis native species are posted including their morphologies, habitats, cultivation, diseases, etc. using more than 1,000 photographs.
Sigma-Aldrich offers abstracts and full-text articles by [Kaiwen Ma, Keigo Araki, Solachuddin J A Ichwan, Tamaki Suganuma, Mimi Tamamori-Adachi, Masa-Aki Ikeda].
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Phalaenopsis orchid is an important potted flower with high economic value around the world. We report the 3.1 Gb draft genome assembly of an important winter flowering Phalaenopsis KHM190 cultivar. We generated 89.5 Gb RNA-seq and 113 million sRNA-seq reads to use these data to identify 41,153 protein-coding genes and 188 miRNA families. We also generated a draft genome for Phalaenopsis pulcherrima B8802, a summer flowering species, via resequencing. Comparison of genome data between the two Phalaenopsis cultivars allowed the identification of 691,532 single-nucleotide polymorphisms. In this study, we reveal the key role of PhAGL6b in the regulation of flower organ development involves alternative splicing. We also show gibberellin pathways that regulate the expression of genes control flowering time during the stage in reproductive phase change induced by cool temperature. Our work should contribute a valuable resource for the flowering control, flower architecture development, and breeding of the
Flower generally bisexual, generally radial; perianth often showy, segments generally 6 in two petal-like whorls (outer sometimes sepal-like), free or fused at base; stamens 6 (or 3 + generally 3 ± petal-like staminodes), filaments sometimes attached to perianth or fused into a tube or crown; ovary superior or inferior, chambers 3, placentas generally axile, style generally 1, stigmas generally ...
Henriettes herbal is one of the oldest and largest herbal medicine sites on the net. Its been online since 1995, and is run by Henriette Kress, a herbalist in Helsinki, Finland.. ...
A new and distinct variety of |i|Phalaenopsis |/i|plant named PHALDESXEN, particularly characterized by purple-lilac spotted flowers that are a little bit striped, |b|2|/b| peduncles, inflorescence
Also known as moth orchids for their delicate white blossoms, Phalaenopsis orchids grow in U.S. Department of Agriculture plant hardiness zones 10 and 11. They are low maintenance to grow at home as ...
Theres just one word to describe our Phalaenopsis orchid: stunning! Surrounded by lush ivy, skillfully formed into the shape of a heart, and featuring a glittering red heart accent floating at the center, this unique and romantic Valentines surprise arrives in a striking silver planter to let her know your love is forever.
Anyone knows if its possible to find Eric Christenson Phalaenopsis: a monograph book in Epub or PDF version? Ive spent the last few hours trying to
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I appreciate their work on my project. Every request was responded to quickly, and they customized exactly as we needed it. Were already thinking up new customizations and will definitely be back.. ...
Numerous reports have suggested that disturbances in nuclear condensation may result in male infertility. This notion has been supported by the observation of infertile individuals with a decrease or absence of the male sperm-specific chromatin packaging protamine proteins. To date, no correlation between the absence of protamine proteins and a mutation within the coding regions of the protamine genes has been documented. To address this issue, PCR-based mutation scanning analysis has been performed across the human male haploid expressed PRM1--|PRM2--|TNP2 domain in several oligozoospermic infertile individuals. This analysis identified a candidate mutation in a region of contact with the sperm nuclear matrix from 2 of 5 affected individuals. This is the first report of a mutation scan covering the entire PRM1--|PRM2--|TNP2 locus in affected individuals.
Marine cyanobacteria of the genus Prochlorococcus represent numerically dominant photoautotrophs residing throughout the euphotic zones in the open oceans and are major contributors to the global carbon cycle. Prochlorococcus has remained a genetically intractable bacterium due to slow growth rates and low transformation efficiencies using standard techniques. Our recent successes in cloning and genetically engineering the AT-rich, 1.1 megabase (Mb) Mycoplasma mycoides genome in yeast encouraged us to explore similar methods with Prochlorococcus. Prochlorococcus MED4 has an AT-rich genome, with a GC content of 30.8%, similar to that of Saccharomyces cerevisiae (38%), and contains abundant yeast replication origin consensus sites (ACS) evenly distributed around its 1.66 Mb genome. Unlike Mycoplasma cells, which use the UGA codon for tryptophane, Prochlorococcus uses the standard genetic code. Despite this, we observed no toxic effects of several partial and 15 whole Prochlorococcus MED4 genome ...
TY - JOUR. T1 - Identifying Nuclear Matrix-Attached DNA Across the Genome. AU - Dobson, Jason R.. AU - Hong, Deli. AU - Barutcu, A. Rasim. AU - Wu, Hai. AU - Imbalzano, Anthony N.. AU - Lian, Jane B.. AU - Stein, Janet L.. AU - van Wijnen, Andre J. AU - Nickerson, Jeffrey A.. AU - Stein, Gary S.. PY - 2016. Y1 - 2016. N2 - Experimental approaches to define the relationship between gene expression and nuclear matrix attachment regions (MARs) have given contrasting and method-specific results. We have developed a next generation sequencing strategy to identify MARs across the human genome (MAR-Seq). The method is based on crosslinking chromatin to its nuclear matrix attachment sites to minimize changes during biochemical processing. We used this method to compare nuclear matrix organization in MCF-10A mammary epithelial-like cells and MDA-MB-231 breast cancer cells and evaluated the results in the context of global gene expression (array analysis) and positional enrichment of gene-regulatory ...
MSY1 is the only hypervariable minisatellite on the human Y chromosome. Arrays contain 22-114 AT-rich repeat units of 25bp in length, of which eighteen different sequence-variant types have been identified. MSY1 maintains ,99% virtual heterozygosity despite the absence of interallelic processes on the haploid and non-recombining Y chromosome. This thesis aimed to determine the types and rates of mutation events that were occurring at MSY1. Single-molecule analysis was used to analyse mutation in the sperm and blood DNA of a single donor. Sperm mutation rate was 2.6%, and mutants were small-scale length changes and isometric mutations that alter the internal structure of arrays but not array length. Overall mutation rate in blood was similar (1.8%), but the spectrum of mutation types was markedly different, suggesting that somatic and germline mutation processes are distinct. Analysis of MSY1 diversity in the framework of the Y phylogeny defined by binary markers allowed inferences to be made ...
A new and distinct variety of Phalaenopsis plant named PHALGIQUEJ, particularly characterized by having white, shaded, striped, dotted, and edged flowers with dark red-purple lips, 1 to 3 peduncles that are long and sturdy, leaves that are oblong, and is propagated by meristem tissue culture, is disclosed.
Pridgeon, A.M., Cribb, P.J., Chase, M.W. & Rasmussen, F.N. (eds.) (2014) Genera Orchidacearum Volume 6: Epidendroideae (Part three); page 233 ff., Oxford: Oxford University Press. ISBN 9780199646517 ...
nit: Im not really sure what the convention is here, but I wonder if its better to just have two RUN lines, where the former checks the full output of the IR itself (more than just the IR-NOT, and instead of checking the debug output of the pass), and one that checks the full output of the asm (or at least more than just the load/store). The reason Im suggesting checking more of the IR/asm is to check that there are no redundant instructions for other purposes. Im also not sure if testing debug-output is normally desirable, but if we just check the output, we can remove the ...
There is some disagreement on the phylogeny of the orders, especially for the location of the Pelagibacterales, but overall there is some consensus. This issue stems form the large difference in gene content (eg. genome streamlining in Pelagibacter ubique) and the large difference in GC-richness between members of several order.[2] Specifically,Pelagibacterales, Rickettsiales and Holosporales contains species with AT-rich genomes. It has been argued that it could be a case of convergent evolution that would result in an artefactual clustering.[6][7][8] However, several studies disagree,.[2][9][10][11] Furthermore, it has been found that the GC-content of ribosomal RNA, the traditional phylogenetic marker, little reflects the GC-content of the genome: for example, members of the Holosporales have a much higher ribosomal GC-content than members of the Pelagibacterales and Rickettsiales, which have similarly low genomic GC-content, because they are more closely related to species with high genomic ...
Centromere DNA element II (CDEII) of budding yeast centromeres is an AT-rich sequence essential for centromere (CEN) function. Sequence analysis of Saccharomyces cerevisiae CDEIIs revealed that A(5-7)/T(5-7) tracts are statistically overrepresented at the expense of AA/TT and alternating AT. To test the hypothesis that this nonrandom sequence organization is functionally important, a CEN library in which the CDEII sequences were randomized was generated. The library was screened for functional and nonfunctional members following centromere replacement in vivo. Functional CENs contained CDEIIs with the highly biased A(n)/T(n) run distribution of native centromeres, while nonfunctional CDEIIs resembled those picked from the library at random. Run content, defined as the fraction of residues present in runs of four or more nucleotides, of the functional and nonfunctional CDEII populations differed significantly (P | 0.001). Computer searches of the genome for regions with an A + T content comparable to
​​​​​Phalaenopsis spp. nursery stock can be imported into Australia either as nursery stock other than tissue cultures, or as tissue cultures (please see the departments import conditions database BICON for conditions). Phalaenopsis spp. nursery stock other than tissue cultures can be imported from a non-approved source or from a high health approved source.
Open Science is a Research Accelerator, M. Woelfle, P. Olliaro and M. H. Todd, Nature Chemistry 2011, 3, 745-748. Paper (mentioned on the cover) Discussed here Resolution of Praziquantel, M. Woelfle, J.-P. Seerden, J. de Gooijer, K. Pouwer, P. Olliaro and M. H. Todd, PLoS Negl. Trop. Dis. 2011, 5(9): e1260. Paper Picked up on the WHO website Polyamide-scorpion Cyclam Lexitropsins Selectively Bind AT-rich DNA Independently of the Nature of the Coordinated Metal, A. T. S. Lo, N. K. Salam, D. E. Hibbs, P. J. Rutledge and M. H. Todd, PLoS One 2011 6(5): e17446. Paper Chemical Sensors that Incorporate Click-Derived Triazoles, Y. H. Lau, P. J. Rutledge, M. Watkinson and M. H. Todd, Chem. Soc. Rev. 2011 40, 2848-2866. Paper A DDQ-mediated Oxidative Carbon-carbon Bond Forming Reaction Proceeds via an Isolable Iminium Ion A. S.-K. Tsang, P. Jensen, J. M. Hook, A. S. K. Hashmi and M. H. Todd, Pure Appl. Chem. 2011, 83, 655-665. Paper A Treasure Hunt for Chemistry, A. J. Bridgeman, R. Connor, P. J. ...
Bulb: 1.5 cm in diameter, ovoid, without bulbils or stolons. Stem: 15-51 cm, 12-3-(-45) cm above ground, smooth. Leaves: 4-7, somewhat glaucous, all alternate, the lowest 5-11 × 1.5-2 cm, narrowly oblanceolate to elliptic-oblong, usually folded at fruiting time; bract leaves 2-5 cm long, linear to narrowly lanceolate, acute. Flowers: 1-2, narrowly campanulate; perianth segments purplish outside, paler inside with median yellowish-green bands extending to apices, sometimes tinged or sparsely green-dotted towards margins, outer segments 12 × 16-46 mm, elliptic-narrowly oblong, obtuse, inner segments 6.5-8 mm wide, lanceolate obtuse. Nectaries: broadly lanceolate to narrowly elliptic, 2.5-4 mm long placed 0.5-1 mm above base of tepals, green. Filaments: 7-8 mm, yellow-brown, stout, glabrous to sparsely papillose at base, densely papillose in upper part; anthers 5-7 mm long before dehiscence, ellipsoid, brown-purplish, basifixed. Style: 6-8 mm, entire, stout, greenish-yellow, densely papillose. ...
The host plant spectre of a parasite is rarely known exhaustively; this applies in particular at the species level. It is advisable therefore to check at least also the list of all parasites of this genus ...
While we have our share of daffodils, tulips, hyacinths and the like, there is also an attraction here to the little oddballs of the bulb world, the Fritillaria ssp. Fritillaria is a genus in the Liliaceae family distributed throughout Europe and North Africa (especially around the Mediterranean), temperate Asia and North America. Most of them…
Our Nearly Natural Phalaenopsis Silk Orchid Flower w/Leaves have it all - established flowers, newly opening flowers, buds, leaves, and even aerial roots - everything you need to craft your own silk arrangements highlighting these beautiful flowers. Place your order today and get ready to put your talent to use! Color:
When that fender bender does a number on your automobile, make your car like new again with the expert care at Rich Burns Certified Collision in Youngstown. Take advantage of their quick and easy oil changes. If you are due for a tire change or rotation, this shop has great and affordable service options. Youll forget all about that fender bender - after a trip to Rich Burns Certified Collision, your car will look good as new! Its high time you took care of some body work on your car. Make sure its done right with a visit to the folks at Rich Burns Certified Collision. Whether youre looking to get some major repairs done or just need a check-up, the auto specialists at Rich Burns Certified Collision are there to help.
When using the gene expression search we felt it would be most valufuable if high quality images appeared near the top of your search results. That is why we have developed a way to allow our users to vote on the quality of an image. You can change your vote for a given image as many times as you want, but only your last vote is counted. Additionally,weve provided a comment box if you want to tell us why you think a specific image is good or bad ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Contact person for questions about Copr. Also can triage any issues with Copr. Will hang on #fedora-buildsys. Miroslav Suchý - SMS: +420 603 775737, Telegram, IRC nick: msuchy at #fedora-buildsys on libera.chat. ...
When the state attempts to restrict any Constitutional right, it has the burden to prove both the necessity and the effectiveness of doing so.
http://www.hildegard.org/music/music.html (accessed December 7, 2011). Richard L. Crocker, et al. "Sequence (i)." Grove Music ... Columba Aspexit is a sequence written by Hildegard of Bingen in the late 12th century. It is one of seven sequences from her ... While most sequences have rhymed pairs of lines, Hildegard's are more through-composed. Columba Aspexit was written about St. ... Columba Aspexit, sequence for Maximinus. Hildegard von Bingen: O Nobilissima Viriditas. Catherine Schroeder, voice. Media 7, ...
Sloane, N. J. A. (ed.). "Sequence A003001". The On-Line Encyclopedia of Integer Sequences. OEIS Foundation. Eric W. Weisstein ... Guy, Richard K. (2004). Unsolved problems in number theory (3rd ed.). Springer-Verlag. pp. 398-399. ISBN 978-0-387-20860-2. Zbl ... sequence A006050 in the OEIS) The next number in the sequence (the smallest number of additive persistence 5) is 2 × 102×(1022 ... sequence A003001 in the OEIS) The search for these numbers can be sped up by using additional properties of the decimal digits ...
Sloane, N. J. A. (ed.). "Sequence A003001". The On-Line Encyclopedia of Integer Sequences. OEIS Foundation. Guy, Richard K. ( ... sequence A003001 in the OEIS) The search for these numbers can be sped up by using additional properties of the decimal digits ... However, any number that is missing from the sequence above would have multiplicative persistence > 11; such numbers are ...
... intron sequence ... Y-U-R-A-C (branch sequence 20-50 nucleotides upstream of acceptor site) ... Y-rich-N-C-A-G-[cut]-G ( ... The term intron refers to both the DNA sequence within a gene and the corresponding sequence in the unprocessed RNA transcript ... "Next-generation SELEX identifies sequence and structural determinants of splicing factor binding in human pre-mRNA sequence". ... The consensus sequence for an intron (in IUPAC nucleic acid notation) is: G-G-[cut]-G-U-R-A-G-U (donor site) ... ...
"Saturday Sequence" (Interview). Interviewed by Richard Skinner. BBC Radio 1. Archived from the original on 24 May 2006. ... Drummond recalled the experience in a BBC Radio 1 interview with Richard Skinner in late 1990. Skinner called the record an " ...
Drummond, Bill (December 1990). "Saturday Sequence" (Interview). Interviewed by Richard Skinner. BBC Radio 1. Archived from the ...
Scene: Credits sequence. Adrian Moore, Lead Designer Stanton, Rich (20 May 2016). "Lionhead: the rise and fall of a British ...
Drummond, Bill (December 1990). "Saturday Sequence" (Interview). Interviewed by Richard Skinner. BBC Radio 1. Archived from the ... The second single in this sequence - Drummond and Cauty's third and final single of 1987 - was "Down Town", a dance record ... Morrison, Richard (17 November 2007). "Just Shut Up". The Times. Retrieved 17 October 2020. McClean, Andrew (3 December 2013 ... In his book 45, Drummond expressed his admiration for the work of artist Richard Long, who incorporates physical journeys into ...
Drummond, Bill (December 1990). "Saturday Sequence" (Interview). Interviewed by Richard Skinner. BBC Radio 1. Archived from the ... His plan, upon retrieving the $20,000 in cash, is to walk with it to the remote place in Iceland where Richard Long had made ... In 1995, Drummond bought A Smell of Sulphur in the Wind by Richard Long, for $20,000. In Drummond's own words, he 'fell in love ... hang it in the same place in his bedroom where the Richard Long hung, and call the new work The Smell of Money Underground. ...
Bohlander, Richard E., ed., World Explorers and Discoverers (New York: Macmillan, 1992); bibliography and reading list online ... Explorers sequence, information; retrieved 2011-02-25. [http://www.pem.org/sites/neptune/default.htm [https://web.archive.org/ ... Christopher H. Sterling and Richard M. Langworth, "A naval triumph by Barry Gough", The Churchill Project, Hillsdale College, ... Richard Watts, "Our History: When Britannia ruled the waves," Times Colonist, 9 Jan 2016, retrieved 2016-01-11 here. Rose ...
"Saturday Sequence" (Interview). Interviewed by Richard Skinner. BBC Radio 1. Archived from the original on 24 May 2006. America ...
For example, a genetically modified form of HIV has been created in which the virus's codons (a sequence of three nucleotides ... Compared with overview in: Fisher, Bruce; Harvey, Richard P.; Champe, Pamela C. (2007). Lippincott's Illustrated Reviews: ... HIV Sequence Compendium (Report). Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, NM, LA-UR 17-25240 ...
Catuneanu, Octavian (2006). Principles of sequence stratigraphy. Amsterdam: Elsevier. Kowalewsky, Michal; Bambach, Richard K. ( ... Kowalewsky, Michal; Bambach, Richard K. (2003). Harries, Peter J. (ed.). High-resolution approaches in stratigraphic ...
Guy, Richard; Unsolved Problems in Number Theory, p. 7 ISBN 1475717385 Sloane, N. J. A. (ed.). "Sequence A005384 (Sophie ... Sloane, N. J. A. (ed.). "Sequence A088054 (Factorial primes)". The On-Line Encyclopedia of Integer Sequences. OEIS Foundation. ... Sloane, N. J. A. (ed.). "Sequence A050918 (Woodall primes)". The On-Line Encyclopedia of Integer Sequences. OEIS Foundation. ... Sloane, N. J. A. (ed.). "Sequence A005385 (Safe primes)". The On-Line Encyclopedia of Integer Sequences. OEIS Foundation. ...
Richard Crocker, The Early Medieval Sequence pp. 1-2. Hiley, Western Plainchant p. 153. Apel, Gregorian Chant p. 404. Chew, ... Crocker, Richard (1977). The Early Medieval Sequence. University of California Press. ISBN 0-520-02847-3. Dyer, Joseph. "Roman ... Although many sequences are not part of the liturgy and thus not part of the Gregorian repertory proper, Gregorian sequences ... but the sequences, like the tropes, were later officially suppressed. The Council of Trent struck sequences from the Gregorian ...
A sequence of colour monoprints of the London Thames by Gwen Barnard with Comments by Eugene Walter. 1955. C.H. Sisson. ... Wooff Wooff, or Who Killed Richard Wagner?. A novella with drawings by Franciszka Themerson. 1951 Alfred Jarry. Ubu Roi. Drama ... A poetic sequence. 1950 Stefan Themerson & Barbara Wright. Mr Rouse builds his House. 1950 (Translation of a story for children ...
Richard McIntosh, Status of the search for Wall-Sun-Sun primes (October 2003) OEIS sequence A000129 (Primes p that divide their ... the result is a periodic sequence. The (minimal) period length of this sequence is called the Pisano period and denoted π ( p ... No Wall-Sun-Sun primes are known as of December 2020[update]. In 2007, Richard J. McIntosh and Eric L. Roettger showed that if ... Crandall, Richard E.; Pomerance, Carl (2001). Prime Numbers: A Computational Perspective. Springer. p. 29. ISBN 0-387-94777-9. ...
It was something that Rick had already written. It's a great chord sequence. "The Great Gig in the Sky" and the piano part on " ... on the instrumental song penned by Richard Wright going under the name of "The Great Gig in the Sky". On 4 November 1973, Torry ... "Us and Them," in my view, are the best things that Rick did - they're both really beautiful. And Alan [Parsons] suggested Clare ... constituted co-authorship with keyboardist Richard Wright. Originally, she was paid the standard flat fee of £30 for Sunday ...
In total, there are 4 conserved domains within LRRIQ3: 3 leucine-rich repeats and 1 IQ calmodulin-binding motif. Leucine-rich ... "SAPS < Sequence Statistics < EMBL-EBI". www.ebi.ac.uk. Retrieved 2018-04-30. Kobe B, Deisenhofer J (October 1994). "The leucine ... LRRIQ3 (Leucine-rich repeats and IQ motif containing 3), which is also known as LRRC44, is a protein that in humans is encoded ... LRRIQ3 is rich in lysine residues, with a total of 82 lysines. It is also slightly low on glycines. ...
Guy, Richard K. (1994). Unsolved problems in number theory (2nd ed.). Springer. pp. 7-8. ISBN 0-387-94289-0. Chris Caldwell, " ... sequence A005235 in the OEIS). The Fortunate numbers sorted in numerical order with duplicates removed: 3, 5, 7, 13, 17, 19, 23 ...
Volume 84, Number 3 (1978), 466-470.) Klitzing, Richard. "3D Euclidean tesselations". (sequence A242941 in the OEIS). ...
Lewis, Richard (2001). "An outline history of Monarch Gold Mine Francistown". Botswana Notes and Records. 33: 41-46. hdl:10520/ ... Eriksson, Patrick G.; Altermann, W.; Förtsch, E. B. (1995). "Transvaal Sequence and Bushveld Complex". Mineralium Deposita. 30 ...
"Sequence of Metrorail openings" (PDF). WMATA. 2017. p. 3. Archived from the original (PDF) on July 2, 2018. Retrieved April 1, ... Taube, Richard K. (August 11, 2008). "Chronology of the Virginia Railway Express: 1964 to Present" (PDF). Virginia Railway ...
"Hooray for Trademark Properties and Richard Davis!!!". Sequence Inc. Fraud Files Blog. Archived from the original on April 30, ... Griffin, Richard (July 5, 2015). "Blue Jays' Josh Donaldson No. 1 in all-star voting: Griffin". thestar.com. Retrieved July 5, ... Richard C. Davis, the owner of Trademark Properties, hired Hamilton as the construction foreman. Davis was negotiating the ...
Chezhian, with his rich and corrupt father MLA Deivanayagam (A. L. Alagappan), the State Minister for Forests and Agriculture, ... If Sasi has pruned some of the sequences, Easan would have been a riveting offering". MANIGANDAN K R I, TNN (21 October 2010 ... Poorani's classmates are all too rich and spoiled. She is taken by one of her classmates to a party, where she is raped by ... Easan has a flashback sequence. His father was a government employee in their native village, where he and his mute sister ...
Kurella VB, Richard JM, Parke CL, Lecour LF, Bellamy HD, Worthylake DK (May 2009). "Crystal structure of the GTPase-activating ... Its name stems from the fact that its RasGAP-related domain (GRD) has sequence homology to the Sar1 GTPase. It was hypothesized ... Since this area of the protein is conserved in amino acid sequence and structure, it can be characterized by function or ... McCallum SJ, Wu WJ, Cerione RA (1996). "Identification of a putative effector for Cdc42Hs with high sequence similarity to the ...
... sequence A002210 in the OEIS) (with ∏ {\displaystyle \prod } denoting the product over all sequence terms). Although almost all ... David H. Bailey; Jonathan M. Borwein; Richard E. Crandall (1995). "On the Khinchine constant" (PDF). doi:10.1090/s0025-5718-97- ... "A Khinchin Sequence". Cite journal requires ,journal= (help) Aleksandr Ya. Khinchin (1997). Continued Fractions. New York: ... The value obtained is K − 1 = 1.74540566240 … {\displaystyle K_{-1}=1.74540566240\dots } (sequence A087491 in the OEIS). π, the ...
"Sloane's A000931 : Padovan sequence". The On-Line Encyclopedia of Integer Sequences. OEIS Foundation. Retrieved 2016-06-12. " ... Guy, Richard; Unsolved Problems in Number Theory, p. 7 ISBN 1475717385 [1]. "Sloane's A000217 : Triangular numbers". The On- ... "Sloane's A005282 : Mian-Chowla sequence". The On-Line Encyclopedia of Integer Sequences. OEIS Foundation. Retrieved 2016-06-12 ... member of the Mian-Chowla sequence 1897 - member of Padovan sequence 1900 - 1900 (film) or Novecento, 1976 movie 1901 - Sophie ...
University of Göttingen Göttinger Digitalisierungszentrum (GDZ) scan Guy, Richard K.; Nowakowski, Richard J. (1993), "Mousetrap ... sequence A007709 in the OEIS). Cayley, Arthur (1878), "On the game of Mousetrap", Quarterly Journal of Pure and Applied ...
Roger Waters: It was something that Rick had already written. It's a great chord sequence. "The Great Gig in the Sky" and the ... The song began life as a Richard Wright chord progression, known variously as "The Mortality Sequence" or "The Religion Song". ... Rick wrote that music. He remade it for them. It's down to the writer. If my name had been on that track too it wouldn't have ... Richard Wright: Great Gig in the Sky? It was just me playing in the studio, playing some chords, and probably Dave or Roger ...
So they wanted to focus on genetic fragments containing paternally inherited sequences the mother did not share, but had ... "The applicability of that decision on life science inventions should have been firmly put to bed in Judge Rich's In re Bergy ...
Richard C. Frucht (2008). Eastern Europe: An Introduction to the People, Lands, and Culture. ABC-CLIO. ISBN 978-1-57607-800-6. ... "Record of the Vistula ice lobe advances in the Late Weichselian glacial sequence in north-central Poland". Quaternary ...
Wiley, Richard H.; Borum, O. H. (1953). "3-Acetamido-2-butanone". Organic Syntheses. 33: 1. doi:10.15227/orgsyn.033.0001.. ... Ozonolysis, and related dihydroxylation/oxidative sequences, cleave alkenes to give aldehydes or ketones, depending on alkene ...
In December 2016, writing in Nature Dr Richard Buggs reported that the common ash (Fraxinus excelsior)had been sequenced for ... The sequence has been published on the website OpenAshDieBack and offers clues to how the fungus infects trees. The study has ... Teams from The Sainsbury Laboratory (TSL) and the John Innes Centre in Norwich sequenced the genome of the fungus in December ... based on morphological and DNA sequence comparisons, Chalara fraxinea was suggested to be the asexual stage (anamorph) of the ...
Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10. Somat. Cell Mol. Genet. March 1993, 19 (2): ... Corchado, Johnny Cruz; Smith, Richard JH. Dense Deposit Disease/Membranoproliferative Glomerulonephritis Type II. 19 May 2011. ...
It appears that the deer's strong preference for a particular habitat - tall reed and grass areas in rich alluvial deltas - has ... studies of mitochondrial control region and cytochrome b DNA sequences placed it near Capreolus within an Old World section of ...
Sandstones rich in quartz are called quartz arenites, those rich in feldspar are called arkoses, and those rich in lithics are ... Thick sequences of sedimentary (colluvial) breccias are generally formed next to fault scarps in grabens. ...
"Expression and the purification of a disulphide rich protein in a hydrophobic resin environment, bothropstoxin-I a Lys49- ... "Km+, a mannose-binding lectin from Artocarpus inegrifolia: amino acid sequence predicted tertiary structure, carbohydrate ...
Richard Edwards of SFX gave the episode five out of five stars and wrote "Steven Moffat pulls off the remarkable feat of making ... However, the scene was cut from the final episode.[9] A stunt performer for Smith performed the sequence in which a future ... Edwards, Richard (26 June 2010). "TV Review Doctor Who 5.13 "The Big Bang"". SFX. Retrieved 14 January 2012.. ... Haynes wanted the museum to feel "massive and eerie", and coached Blackwood to "live in the moment".[3] The opening sequence ...
2007). "The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence". J. Mol. ...
Eaton, Richard M. (1993). The Rise of Islam and the Bengal Frontier, 1204-1760. University of California. ISBN 978-0-520-20507- ... There is yet to be a uniform standard collating sequence (sorting order of graphemes to be used in dictionaries, indices, ...
Carson, Lange; Richard Carson (1984). "EM reconstruction algorithm for emission and transmission tomography". Journal of ... Because the two scans can be performed in immediate sequence during the same session, with the patient not changing position ...
There is a regularity in these angles and they follow the numbers in a Fibonacci sequence: 1/2, 2/3, 3/5, 5/8, 8/13, 13/21, 21/ ... The mesophyll tissue inside the leaf, which is rich in chloroplasts (also called chlorenchyma) ... and botanists have developed a rich terminology for describing leaf characteristics. Leaves almost always have determinate ...
Richard Preston's 1995 best-selling book, The Hot Zone, dramatised the Ebola outbreak in Reston, Virginia.[231][232][233] ... Genome-sequencing showed that this outbreak was not related to the 2014-15 West Africa Ebola virus outbreak, but was the same ... Preston, Richard (1995). The Hot Zone, A Terrifying True Story. Anchor Books. ISBN 978-0-385-47956-1. . OCLC 32052009. Archived ... Preston, Richard (20 July 1995). The Hot Zone. Anchor Books (Random House). p. 117. Karl Johnson named it Ebola. ...
Abraham, Richard L. (1 October 1974). "Vocalizations of the Mallard (Anas Platyrhynchos)" (PDF). The Condor: Ornithological ... Mitochondrial DNA data for the D-loop sequence suggests that mallards may have evolved in the general area of Siberia. Mallard ... Smith, Loren M.; Pederson, Roger L.; Kaminski, Richard M. (1989). Habitat Management for Migrating and Wintering Waterfowl in ... van Toor, Mariëlle L.; Hedenström, Anders; Waldenström, Jonas; Fiedler, Wolfgang; Holland, Richard A.; Thorup, Kasper; Wikelski ...
Contributed by Richard B. Potts, B.A., Ph.D. *^ a b Ann Parson. "Neanderthals Hunted as Well as Humans, Study Says". National ... "Callaway, Ewen (22 September 2011), "First Aboriginal genome sequenced", Nature, Nature News, doi:10.1038/news.2011.551 ... Rick Weiss, "Chimps Observed Making Their Own Weapons", The Washington Post, February 22, 2007 ... "Human Evolution," Microsoft Encarta Online Encyclopedia 2007 Archived 2009-11-01 at WebCite Contributed by Richard B. Potts, B. ...
Its existence was first proven in 1962,[4] and first sequenced in 1986-when two Japanese research teams sequenced the ... At the N-terminal end is the A-domain, which is rich in acidic amino acids and takes up about half the protein length.[38][48] ... both very common in chloroplast transit sequences-making up 20-30% of the sequence)[45] are often the amino acids that accept ... Chloroplast transit peptides exhibit huge variation in length and amino acid sequence.[42] They can be from 20-150 amino acids ...
Breitman, Richard (1991). The Architect of Genocide: Himmler and The Final Solution. New York: Alfred A. Knopf. ISBN 0-394- ... "sequence of steps in a destruction process is thus determined". If a bureaucracy is motivated "to inflict maximum damage upon a ... Lukas, Richard (1989). Out of the Inferno: Poles Remember the Holocaust. University Press of Kentucky. pp. 5, 13, 111, 201. ... Lukas, Richard (2012) [1986]. The Forgotten Holocaust: Poles Under Nazi Occupation 1939-1944. New York: University of Kentucky ...
"Richard Freeman's HP Part numbers Crossreference". Hpmuseum.org. Archived from the original on June 5, 2012. Retrieved June 30, ... A 3-digit sequence number (or one letter then two digits, for industrial types) follows. With early devices this indicated the ... Hirsh, Rick. "Philco's All-Transistor Mopar Car Radio". Allpar.com. Retrieved February 18, 2015.. ...
In a sebum-rich skin environment, the naturally occurring and largely commensal skin bacterium C. acnes readily grows and can ... scientists reported the first genome sequencing of a C. acnes bacteriophage (PA6). The authors proposed applying this research ... This led to the current understanding that acne could be explained by a sequence of related events, beginning with blockage of ... "Genome sequence and analysis of a Propionibacterium acnes bacteriophage". Journal of Bacteriology. 189 (11): 4161-7. doi ...
Mandalasana, Circle pose, is not a single variation but a sequence of movements in Shirshasana in which the legs move in a full ... International Association of Yoga Therapists • Richard Miller. *Janice Gates. Events. *Competitive yoga ...
... mismatch as small as a single DNA base pair is significant so perfect matches require knowledge of the exact DNA sequence of ...
Ruppert, Edward E.; Fox, Richard S.; Barnes, Robert D. (2008). Invertebrate Zoology. Cengage Learning. pp. 363-364. ISBN 978-81 ... The California two-spot octopus has had its genome sequenced, allowing exploration of its molecular adaptations.[151] Having ... Octopuses and other coleoid cephalopods are capable of greater RNA editing (which involves changes to the nucleic acid sequence ... The arms can be described based on side and sequence position (such as L1, R1, L2, R2) and divided into four pairs.[23][22] The ...
In food-rich habitats, nests can be quite close together, and are often found in the same area as those of the sarus crane. The ... "Mitochondrial genome sequences and the phylogeny of cranes (Gruiformes: Gruidae)". Auk. 127 (2): 440-452. doi:10.1525/auk. ...
Stewart, Eric J.; Richard Madden; Gregory Paul; Francois Taddei (2005). "Aging and Death in an Organism That Reproduces by ... In 2010, the Caulobacter NA1000 strain was sequenced and all differences with the CB15 "wild type" strain were identified.[6] ... The cell cycle-regulated synthesis and removal of these polarly localized structures have provided a rich playground for the ... "Complete genome sequence of Caulobacter crescentus". Proceedings of the National Academy of Sciences of the United States of ...
Orwin), Philip Craig (Gene Orwin), Beau Starr (Malcolm Vedder), Richard Waugh (Dr. Morley) and Ken Kramer (Dr. Vollmer). ... opening sequence).[4] ...
Adams, Richard Calmit, The Delaware Indians, a brief history, Hope Farm Press (Saugerties, NY 1995) [originally published by ... According to historian Steven Harper, what followed was a "convoluted sequence of deception, fraud, and extortion orchestrated ... Hoffecker, Carol E., Richard Waldron, Lorraine E. Williams, and Barbara E. Benson (editors). New Sweden in America. University ...
Keynes, Richard (2000), Charles Darwin's zoology notes & specimen lists from H.M.S. Beagle, Cambridge University Press, ,http ... Sato et al. Phylogeny of Darwin's finches as revealed by mtDNA sequences in PNAS ...
Richard Rotunno, Joseph Klemp; Klemp (1985). "On the Rotation and Propagation of Simulated Supercell Thunderstorms". J. Atmos. ... A sequence of images showing the birth of a tornado. First, the rotating cloud base lowers. This lowering becomes a funnel, ... Other rich areas of research are tornadoes associated with mesovortices within linear thunderstorm structures and within ... Main articles: Tornado family, tornado outbreak, and tornado outbreak sequence. Occasionally, a single storm will produce more ...
A new classification and linear sequence based on molecular data can be found in an article by Christenhusz et al.[7] ... Lott, John N. A; Liu, Jessica C; Pennell, Kelly A; Lesage, Aude; West, M Marcia (2002). "Iron-rich particles and globoids in ... Ledig, F. Thomas; Porterfield, Richard L., 1982, Tree Improvement in Western Conifers: Economic Aspects, Journal of Forestry ... but recent research into DNA sequences suggests that this interpretation leaves the Pinales without Taxales as paraphyletic, ...
Structure of the lnlB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. ... Structures of protein chains with identical sequences (sequence identity > 95%) are aligned, superimposed and clustered. ... Sequence Similarity Clusters for the Entities in PDB 1D0B Legend Entity #1 , Chains: A INTERNALIN B protein, length: 213 (BLAST ... Blast this sequence against all of PDB Archive.. Rank. In each cluster, the chains are sorted (i.e. ranked) according to the ...
... cloning and sequencing. PGRS was present in at least 26... ... The polymorphic GC-rich repetitive sequence (PGRS) found on the ... The polymorphic GC-rich repetitive sequence (PGRS) found on the chromosome of Mycobacterium tuberculosis was characterized by ... Characterization of the highly abundant polymorphic GC-rich-repetitive sequence (PGRS) present in Mycobacterium tuberculosis. ... Staden R (1987) Computer handling of sequence projects. In: Bishop MJ, Rawling CJ (eds) Nucleic acid and protein sequence ...
cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica.. B E Torian, B M Flores, ... cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica. ... The deduced amino acid sequence of the cDNA revealed a cysteine-rich protein. DNA hybridizations showed that the gene was ... cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica. ...
Why are you sequencing Richard IIIs genome?. Sequencing Richard IIIs genome will shed light on his ancestry, genetic ... You are here: Home / Offices / Press Office / For Journalists / Richard III / Features / Richard III sequencing - Background Q& ... Will Richard IIIs sequence really tell us anything meaningful?. As Richard III is a known historical individual, his genome ... What does genome sequencing mean?. Whole genome sequencing is a way of reading a persons DNA. It reveals the exact order of ...
Factors associated with a purine-rich exonic splicing enhancer sequence in Xenopus oocyte nucleus.. Masuyama K1, Taniguchi I, ... Here we show that a GAA repeat RNA sequence, a typical ESE, is associated in Xenopus oocyte nuclei with at least one SR protein ... Purine-rich exonic splicing enhancers (ESEs) stimulate splicing of the adjacent introns with suboptimal splice sites. To ... serine/arginine-rich) proteins. However, factors associated with ESEs in vivo have not yet been explored. ...
Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich ... Structures of protein chains with identical sequences (sequence identity > 95%) are aligned, superimposed and clustered. ... Sequence Similarity Clusters for the Entities in PDB 2H8N Legend Entity #1 , Chains: A,B,C,D Histone deacetylase 4 protein, ... Blast this sequence against all of PDB Archive.. Rank. In each cluster, the chains are sorted (i.e. ranked) according to the ...
... Author: Truong, Thanh; Issac, Biju; Mendenhall, Eric M; Koche, ... GC-rich sequence elements recruit PRC2 in mammalian ES cells. DSpace/Manakin Repository. * DASH Home ... Our findings demonstrate a causal role for GC-rich sequences in PRC2 recruitment and implicate a specific subset of CpG islands ... GC-rich sequence elements recruit PRC2 in mammalian ES cells. PLoS Genetics 6(12): e1001244.. ...
What We Do Richard Dawkins Richard Dawkins Award Merger with CFI- FAQ Board Staff Press Website FAQ ... What We Do Richard Dawkins Richard Dawkins Award Merger with CFI- FAQ Board Staff Press Website FAQ ... One comment on "Cryptic DNA sequences may help cells survive starvation" *. Jan 21, 2019 at 10:38 am. ... But many genes contain introns: sequences of non-coding DNA, the vast majority of which dont appear to do anything. ...
Sequence analysis and lipid modification of the cysteine-rich envelope proteins of Chlamydia psittaci 6BC.. K D Everett, T P ... Sequence analysis and lipid modification of the cysteine-rich envelope proteins of Chlamydia psittaci 6BC. ... Sequence analysis and lipid modification of the cysteine-rich envelope proteins of Chlamydia psittaci 6BC. ... Sequence analysis and lipid modification of the cysteine-rich envelope proteins of Chlamydia psittaci 6BC. ...
Exome sequencing of family trios from the National Birth Defects Prevention Study: Tapping into a rich resource of genetic and ... Successful sequencing of exomes from well-characterized NBDPS families indicated that this unique collection can be used to ... Quality metrics of sequenced gDNA were consistently higher than metrics from corresponding WGA products and were consistently ... NIH Intramural Sequencing Center, National Human Genome Research Institute, Bethesda, Maryland.. 21. University of Washington, ...
Using DNA sequencing technique, we narrowed down a short CpG-rich segment (eight specific CpG sites in the CpG island within ... Differential Methylation of a Short CpG-Rich Sequence within Exon 1 of TCF21 Gene: A Promising Cancer Biomarker Assay. Narayan ... It appears from our data that methylation of the short CpG-rich sequence in the TCF21 gene may have significant potential as a ... In this article, we identified a short CpG-rich sequence within exon 1 of the TCF21 gene that was differentially methylated in ...
To identify the regulatory sequences involved in symbiosis-related MtENOD11 expression, a series of promoter deletions driving ... Site-directed mutagenesis further showed that a previously identified nodule-specific AT-rich motif is required for high-level ... In particular, the 257-bp promoter sequence immediately upstream from the start codon is sufficient for infection-related ... MtENOD11 Gene Activation During Rhizobial Infection and Mycorrhizal Arbuscule Development Requires a Common AT-Rich-Containing ...
168h) The Binary Effect on Drug-Resistant Bacteria of Polymeric Vesicles Appended By Proline-Rich Amino Acid Sequences and ...
Comparative sequence analyses revealed that this family of mosquito LRIM-like genes is characterised by a variable number of 6 ... Two of these immune factors are LRIM1 and APL1C, which are leucine-rich repeat (LRR) containing proteins that activate ... In addition to their LRR domains, these leucine-rich repeat immune (LRIM) proteins share several structural features including ... 20 LRIM-like genes exhibiting all or most of their sequence features in each of three disease-vector mosquitoes with sequenced ...
The genetic code of King Richard III, the medieval monarch whose body was found buried under a parking lot in Leicester, ... King Richard IIIs Genome To Be Sequenced Below:. * * x Jump to discuss comments below ... Sequencing the genome of Richard III is a hugely important project that will help to teach us not only about him, but ferment ... Richard III in life and death. Richard III was the last English king to die in battle. He perished in the Battle of Bosworth ...
TLRs are membrane glycoproteins and contain leucine rich repeat (LRR) motif in the ectodomain. TLRs recognize and respond to ... Multiple sequence alignment, sequence similarity search and dot plot analysis. Multiple sequence alignments and sequence ... Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. ... Sequence alignment of super-repeat of LRRs within TLR7, TLR and TLR9 from human and mouse and TLR from green puffer. human TLR7 ...
... March 28, 2019. A new technique developed by ... The Broad team sequences each of those barcodes, generating data that later allows users to determine where the sequencing ... "Single-cell RNA sequencing is really good at telling you what kind of cells are in your sample," said co-first author Samuel ... In recent years, RNA sequencing has enabled scientists to identify which cell types are present in a tissue and which genes are ...
Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin Martin E. Lidell ; Martin E. ... Martin E. Lidell, Gunnar C. Hansson; Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC ... This sequence is also found in the human MUC2 mucin, previously shown to be cleaved at the same site by a slow, non-enzymatic ... The site of cleavage was located at an Asp-Pro bond situated in a GDPH (Gly-Asp-Pro-His) sequence found in the vWD4 (von ...
These AU-rich sequences appear to be key determinants of the short half-lives of these mRNAs, although the sequence features of ... The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation.. A M Zubiaga, J G Belasco, M E ... Instead, the nonomer UUAUUUAUU is the elemental AU-rich sequence motif that destabilizes mRNA. Removal of one uridine residue ... Labile mRNAs that encode cytokine and immediate-early gene products often contain AU-rich sequences within their 3 ...
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus ... CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus ... CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus ... CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus ...
King Richard III DNA to be Sequenced added by Douglas Cobb on February 13, 2014. View all posts by Douglas Cobb → ... King Richard III DNA to be Sequenced By Douglas Cobb on February 13, 2014. 1 Comment ... Scientists intend to sequence the entire genetic code of King Richard III, and, among other things, discover who, today, is ... The leader of the project to produce the complete genome sequence of King Richard III will be geneticist Turi King. The entire ...
Sequences of oligomers used in our studies.. * Table S5. Calculated Tm of synthetic HCV G-rich sequences in the presence of ... Sequences of oligomers used in our studies.. Table S5. Calculated Tm of synthetic HCV G-rich sequences in the presence of ... 1 Graphical representations of G-rich sequences consensus in the HCV genome.. (A and B) A total of 1056 partial cds of the C ... 2 Synthetic HCV G-rich sequences form G4 RNAs.. (A) Formation of compact G4 RNAs characterized on the basis of species that ...
A conserved guanine-rich sequence could be a new target for anti-hepatitis C virus drug development. ... A conserved guanine-rich sequence could be a new target for anti-hepatitis C virus drug development. ... A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target ... A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target ...
... .. ... Survey of glycine-rich proteins (GRPs) in the Eucalyptus expressed sequence tag database. ... Survey of glycine-rich proteins (GRPs) in the Eucalyptus expressed sequence tag database. ... The occurrence of quasi-repetitive glycine-rich peptides has been reported in different organisms. Glycine-rich regions are ...
Special AT-rich sequence-binding protein 1 (SATB1) is a cell type-specific matrix attachment region binding protein, ... AIM: Special AT-rich sequence-binding protein 1 (SATB1) is a cell type-specific matrix attachment region binding protein, ... Loss of special AT-rich sequence-binding protein 1 (SATB1) predicts poor survival in patients with colorectal cancer. Abstract ... Loss of special AT-rich sequence-binding protein 1 (SATB1) predicts poor survival in patients with colorectal cancer ...
In contrast to the codon optimized expression vectors, partial replacement of the A-rich HIV-1 sequences with G-rich sequences ... The introduced restriction sites were then used to replace the WT A-rich NL4.3 sequences with the corresponding G-rich sequence ... The unusually high levels of A-rich sequences in pol suggest that the local RNA sequences within pol would have a flexible ... Overall, these results point to an important role for HIV-1s A-rich sequences in viral infectivity and suggest that the A-rich ...
Sequencing of a QTL-rich region of the Theobroma cacao genome using pooled BACs and the identification of trait specific ... Sequencing of a QTL-rich region of the Theobroma cacao genome using pooled BACs and the identification of trait specific ...
Single-molecule sequencing of an individual human genome, was published in Nature Biotechnology and details the sequencing of ... it appears that formal entry into the human genome sequencing race merely requires generating a genome sequence of the standard ... As for sequence analysis, their ability to call SNPs is comparable to second generation platforms. Their ability to call copy ... What you can take away from this is that you may be able to sequence a human genome with three people, but it takes a village ...
Trees Marked for Felling A11 Bypass, Thetford, UK © Richard Ansett Photography & Environmental Concern, PhotoPlace Gallery ... Trees Marked for Felling A11 Bypass, Thetford, UK © Richard Ansett. Photography & Environmental Concern, PhotoPlace Gallery ...
  • Our findings demonstrate a causal role for GC-rich sequences in PRC2 recruitment and implicate a specific subset of CpG islands depleted of activating motifs as instrumental for the initial localization of this key regulator in mammalian genomes. (nih.gov)
  • At the same time, we are in the midst of a new age of genetic research, with the ability to sequence entire genomes from ancient individuals and with them, those of pathogens that may have caused infectious disease. (nbcnews.com)
  • Other archaeological individuals who have had their genomes sequenced have identities that will never be fully known, such as "Otzi" the Iceman. (nbcnews.com)
  • The bias of A-rich codons in HIV-1 pol is thought to be a record of hypermutations in viral genomes that lack biological functions. (pubmedcentralcanada.ca)
  • Using codon modifications to reduce the amount of A-rich sequences within HIV-1 genomes, we have reduced the flexibility of RNA sequences in pol to analyze the functional significance of these A-rich 'structurally poor' RNA elements in HIV-1 pol . (pubmedcentralcanada.ca)
  • These genomes, which range in size from 15,000 to 1,000,000 base pairs, can now be efficiently sequenced in large numbers using 'multiplexed massively parallel sequencing' (MMPS), a technique developed at the PNW Research Station. (fed.us)
  • We first constructed oligonucleotide BLSOMs for all available sequences from genomes of known species, and by mapping metagenomic sequences on these large-scale BLSOMs, we can predict phylotypes of individual metagenomic sequences, revealing a microbial community structure of uncultured microorganisms, including viruses. (mdpi.com)
  • Even with recent developments in massively parallel DNA sequencing technologies ( 9 ), it still remains expensive to sequence whole genomes and transcriptomes, both of which are required to identify RNA editing targets. (sciencemag.org)
  • Assembly of complex genomes is additionally complicated by the great abundance of repetitive sequences , meaning similar short reads could come from completely different parts of the sequence. (wikipedia.org)
  • [4] [5] However, whole genome shotgun sequencing for small (4000- to 7000-base-pair) genomes had been suggested already in 1979. (wikipedia.org)
  • This cheaper, faster way of sequencing human genomes used to be done mainly in research labs, but now is beginning to transform modern medicine. (fastcompany.com)
  • took samples of both human and viral genomes from 1071 individuals infected with HIV, the AIDS virus, and used genotyping and sequencing technology to obtain a comprehensive description of the genetic variation in both. (elifesciences.org)
  • We will also be able to learn about genes associated with Richard III's physical characteristics, such as hair colour and eye colour - it will be particularly interesting to compare these characteristics to paintings of the king, none of which were contemporary. (le.ac.uk)
  • But many genes contain introns: sequences of non-coding DNA, the vast majority of which don't appear to do anything. (richarddawkins.net)
  • The MOMP gene of Chlamydia psittaci 6BC has been sequenced previously, and the genes encoding the small and large CRPs from this strain were cloned and sequenced in this study. (asm.org)
  • Comparative sequence analyses revealed that this family of mosquito LRIM -like genes is characterised by a variable number of 6 to 14 LRRs of different lengths. (biomedcentral.com)
  • Such a platform offers unparalleled views of the cellular structure of tissues, the roles played by genes in different tissues, and the effects of injury or other perturbations on tissue, giving researchers rich maps of tissue function that have never before been possible. (brightsurf.com)
  • In recent years, RNA sequencing has enabled scientists to identify which cell types are present in a tissue and which genes are turned on across the genome, but not where those cells are precisely located. (brightsurf.com)
  • Since this is the first description of GRPs in this species, particular emphasis has been given to the expression pattern of these genes by analyzing their abundance and prevalence in the different cDNA-libraries of the Eucalyptus Genome Sequencing Project Consortium (ForEST). (ufrgs.br)
  • Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. (nih.gov)
  • From our in silico analyses, we show that the binding motifs for certain transcription factors are enriched in cis-regulatory sequences adjacent to repressed target genes compared to induced target genes, including the motif for RUNX1. (byu.edu)
  • The wheat gene-rich region (GRR) 5L0.5 contains many important genes, including Ph1 , the principal regulator of chromosome pairing. (pnas.org)
  • Physical mapping of 3,025 gene loci on 334 single-break deletion lines identified 18 major and 30 minor gene-rich regions (GRRs), accounting for 85% of known genes and encompassing only ≈29% of the genome ( 2 ). (pnas.org)
  • The Rps1 -k region was sequenced to understand the possible evolutionary steps that shaped the generation of Phytophthora resistance genes in soybean. (biomedcentral.com)
  • Sequence analysis predicted a few full-length genes including two Rps1 -k genes, Rps1 -k-1 and Rps1 -k-2. (biomedcentral.com)
  • Furthermore, rare SNVs, discovered from sequencing of susceptibility genes, may have large effect sizes and account for a part of the heritability of SCZ, and could contribute to an understanding of the etiopathophisiology of neurodevelopmental disease through further functional assays. (nature.com)
  • While genes encoding pseudo-orthocaspases seem to be absent in Archaea, our results show conservation of these genes in organisms performing either anoxygenic photosynthesis (orders Rhizobiales, Rhodobacterales, and Rhodospirillales in Alphaproteobacteria) or oxygenic photosynthesis (all sequenced cyanobacteria, except Gloeobacter , Prochlorococcus , and Cyanobium ). (frontiersin.org)
  • NEW YORK (GenomeWeb) - Profiling mutations in a few hundred genes appears to be a promising method for identifying mutation-rich tumors that may respond to drugs that target the immune checkpoint pathway, according to a new research study led by Foundation Medicine. (genomeweb.com)
  • The price to sequence a single letter-or "base"-of DNA has fallen 100 million-fold since the heyday of the Human Genome Project , the U.S. government-coordinated effort to identify all of the 20,000-plus genes in human DNA that was completed in 2003. (fastcompany.com)
  • These proteins recognise and gather at specific sequences of DNA near genes, and then assist the enzymes that copy the information in the gene into a molecule of RNA. (elifesciences.org)
  • In Drosophila, these repressors are recruited to sequence elements by DNA binding proteins associated with Polycomb repressive complex 2 (PRC2). (nih.gov)
  • To elucidate the mechanism regarding ESEs, factors specifically associated with ESEs in HeLa cell nuclear extracts were previously investigated, and shown to include SR (serine/arginine-rich) proteins. (nih.gov)
  • Sequence analysis and lipid modification of the cysteine-rich envelope proteins of Chlamydia psittaci 6BC. (asm.org)
  • consist largely of disulfide-cross-linked major outer membrane protein (MOMP) and two cysteine-rich proteins (CRPs). (asm.org)
  • Two of these immune factors are LRIM1 and APL1C, which are leucine-rich repeat (LRR) containing proteins that activate complement-like defence responses against malaria parasites. (biomedcentral.com)
  • In addition to their LRR domains, these leucine-rich repeat immune (LRIM) proteins share several structural features including signal peptides, patterns of cysteine residues, and coiled-coil domains. (biomedcentral.com)
  • Two of these factors, LRIM1 and APL1C, are leucine-rich repeat (LRR) containing proteins that form a disulphide-bridged complex that interacts with the third factor, thioester-containing protein 1 (TEP1) a complement C3-like protein. (biomedcentral.com)
  • Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids 1st edition by Durbin, Richard, Eddy, Sean R., Krogh, Anders, Mitchison, Gr (1998) Paperback by Durbin: Cambridge University Press (2 July 2003) Paperback, 1st - may be Reissue. (abebooks.com)
  • In plants, a set of glycine-rich proteins (GRPs) was characterized several years ago, and since then a wealth of new GRPs have been identified. (ufrgs.br)
  • Leucine-rich nuclear export signals (NESs) are short amino acid motifs that mediate binding of cargo proteins to the nuclear export receptor CRM1, and thus contribute to regulate the localization and function of many cellular proteins. (omictools.com)
  • LRG1 belongs to the leucine-rich repeat (LRR) family of proteins, which have been shown to be involved in protein-protein interaction, signal transduction, cell adhesion and development. (prospecbio.com)
  • A short sequence motif rich in glycine residues, Gly-X-X-X-X-Gly-Lys-Thr/Ser, has been found in many nucleotide-binding proteins including the β subunit of Escherichia coli H + -ATPase (Gly-Gly-Ala-Gly-Val-Gly-Lys-Thr, residues 149-156). (elsevier.com)
  • The deduced 87-amino-acid sequence of the small-CRP gene (envA) contains 15 cysteine residues, a potential signal peptide, and a potential signal peptidase II-lipid modification site. (asm.org)
  • The deduced 557-amino-acid sequence of the large-CRP gene (envB) contains 37 cysteine residues and a single putative signal peptidase I cleavage site. (asm.org)
  • Using DNA sequencing technique, we narrowed down a short CpG-rich segment (eight specific CpG sites in the CpG island within exon 1) of the TCF21 gene, which was unmethylated in normal lung epithelial cells but predominantly methylated in lung cancer cell lines. (aacrjournals.org)
  • In our article, using DNA sequencing, we examined lung cancer and bronchial epithelial cell lines for methylation of the CpG island within exon 1 of the TCF21 gene (GenBank accession no. (aacrjournals.org)
  • To identify the regulatory sequences involved in symbiosis-related MtENOD11 expression, a series of promoter deletions driving the β-glucuronidase reporter gene were analyzed in transgenic M. truncatula roots. (apsnet.org)
  • In particular, the 257-bp promoter sequence immediately upstream from the start codon is sufficient for infection-related expression, but is unable to drive gene transcription in response to the Nod factor elicitor. (apsnet.org)
  • Software developed by the Broad team and provided to end users assigns locations to each sequencing read, which can be plotted to generate high-resolution maps of cell types or gene expression, with richer information than that of standard microscopy images. (brightsurf.com)
  • Applying Slide-seq to slices of mouse cerebellum, the team revealed bands of gene activity variation across the tissue, patterns that indicate spatially defined subpopulations that were not discernable using traditional single-cell sequencing. (brightsurf.com)
  • Labile mRNAs that encode cytokine and immediate-early gene products often contain AU-rich sequences within their 3' untranslated region (UTR). (asm.org)
  • CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. (jimmunol.org)
  • Nucleotide sequence of gene PBI encoding a protein homologous to salivary proline-rich protein P-B. (semanticscholar.org)
  • The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. (nih.gov)
  • A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene. (nih.gov)
  • These sequences provided insights into the mechanisms of R gene evolution and generation of novel recognition specificity. (biomedcentral.com)
  • The United States Department of Energy (DOE) Joint Genome Institute (JGI) and Stanford University report today the completion of the sequencing of human chromosome 19, the most gene-rich of all the human chromosomes. (news-medical.net)
  • Here, we apply the first study of using long read sequencing with targeted capture of both the gDNA and cDNA of the SNCA gene in brain tissues of PD, DLB, and control samples using the PacBio Sequel system. (frontiersin.org)
  • The sequences of betasatellites have three major features-a single conserved (in both position and sequence) gene (referred to as βC1), a region of sequence rich in adenine (A-rich) and a sequence conserved among all betasatellites (known as the satellite conserved region (SCR) [ 12 , 14 ]. (mdpi.com)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • The phylogenetic analysis based on sequence homology searches is a well-established and an irreplaceably important method for studying gene and protein sequences [ 1 , 2 , 3 ]. (mdpi.com)
  • Whereas it took nearly 15 years and $3.8 billion to sequence the human genome during the Human Genome Project, gene-sequencing companies now can perform the same feat in a week for less than $10,000, and costs are still rapidly falling. (fastcompany.com)
  • Whole-genome sequencing from Otzi the Iceman, a previously-sequenced ancient individual, found the first known human infection with Lyme disease, for example. (le.ac.uk)
  • cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica. (pnas.org)
  • A 700-base-pair cDNA insert was isolated and the nucleotide sequence was determined. (pnas.org)
  • The deduced amino acid sequence of the cDNA revealed a cysteine-rich protein. (pnas.org)
  • Our data provided direct evidence that the HIV-1 A-rich pol sequence is not merely an evolutionary artifact of enzyme-induced hypermutations, and that HIV-1 has adapted to rely on A-rich RNA sequences to support the synthesis of viral cDNA during reverse transcription, highlighting the utility of using 'structurally poor' RNA domains in regulating biological process. (pubmedcentralcanada.ca)
  • In the present study, an activated m phi cDNA library yielded new Nramp clones that differ in the 5' region from the published pre-B cell-derived clone sequence, resulting in addition of 64 amino acids at the NH2 terminus of the predicted protein. (rupress.org)
  • In this paper, we report the purification from rat liver nuclei, of one of these factors, PYBP, as well as the cloning and the sequencing of its cDNA. (pasteur.fr)
  • cDNA/RNA hybridization experiments of polysomal and nuclear poly(A)-rich RNA from early tadpole stages of Xenopus laevis revealed that part of the nuclear poly(A)-rich RNA sequences are not present within the polysomal polyadenylated RNA. (mysciencework.com)
  • For a more detailed analysis of these sequences we have cloned double-stranded cDNA derived from tadpole nuclear poly(A)-rich RNA in the PstI cleavage site of pBR 322. (mysciencework.com)
  • By colony screening with 32P-labelled cDNA from polysomal and nuclear poly(A)-rich RNA of the tadpole stage we could identify and isolate some of the cloned sequences, which are present only within the nuclear RNA. (mysciencework.com)
  • However, hybridization with cDNA from polysomal poly(A)-rich RNA of the gastrula stage indicated that at least one of those sequences which are confined to the nucleus at tadpole stage may serve as mRNA at gastrula stage. (mysciencework.com)
  • We demonstrate that long gDNA and cDNA reads have the potential to reveal long-range information not previously accessible using traditional sequencing methods. (frontiersin.org)
  • Random primed cDNA library generation was performed, followed by adaptor ligation and Illumina sequencing. (wikipedia.org)
  • We sequenced the amplicons and identified sites where an A allele was observed in gDNA, whereas at least a fraction of G reads were present in the cDNA samples. (sciencemag.org)
  • 1990) The nucleotide sequence of the 60kDa cysteine rich outer membrane protein ofChlamydia psittacistrain EAE/A22/M. Nucleic Acids Research, 18 (17). (edu.au)
  • We present evidence that nuclear and polysomal poly(A)-rich RNA molecules containing the same nucleotide sequence differ in size and that size reduction at the level of processing precedes and may enable cytoplasmic export. (mysciencework.com)
  • After the entire genome is sequenced, any samples of King Richard III taken must be reburied with the skeleton of the monarch. (guardianlv.com)
  • Due to the age of the bones, the king's DNA might be too fragmented for the researchers to create an entire genome sequence. (guardianlv.com)
  • BAC-based physical maps provide for sequencing across an entire genome or a selected sub-genomic region of biological interest. (clemson.edu)
  • Now imagine for a moment that your entire genome had been sequenced. (fastcompany.com)
  • As the cost of sequencing an entire genome drops to about $1,000-roughly the cost of a typical MRI exam today-suddenly the test will become affordable for millions of people. (fastcompany.com)
  • Results: We have determined and analyzed the complete sequences of two of its chromosomes, 11 and 12, which total 55.9 Mb (14.3% of the entire genome length), based on a set of overlapping clones. (cshl.edu)
  • Sequencing Richard III's genome will shed light on his ancestry, genetic predisposition to disease as well as providing information on bacteria and viruses that may have affected his health. (le.ac.uk)
  • In 2013, scientists carried out a mitochondrial DNA test to establish a genetic link between Richard III's skeleton and a known living relative, Michael Ibsen. (le.ac.uk)
  • Analysis of Richard III's genome will allow insight into his genetic make-up in relation to disease, infection, ancestry and identity. (le.ac.uk)
  • The legacy of this sequencing means that as the genetic basis of other diseases and infections become known, this data can be used for many decades to come. (le.ac.uk)
  • Data and information about Richard III already exists, enabling his genome to be used in further population genetic analysis, perhaps to ascertain how his medieval genome sits within a modern European context, the diversity within his genome, and how much genetic information he shares with proven modern relatives. (le.ac.uk)
  • Exome sequencing of family trios from the National Birth Defects Prevention Study: Tapping into a rich resource of genetic and environmental data. (nih.gov)
  • The genetic code of King Richard III, the medieval monarch whose body was found buried under a parking lot in Leicester, England, is set to be sequenced. (nbcnews.com)
  • Sequencing ancient DNA can be challenging, as the nucleic acids that make up the genetic code degrade with time. (nbcnews.com)
  • Known as Slide-seq, the method uses genetic sequencing to draw detailed, three-dimensional maps of tissues, revealing not only what cell types are present, but where they are located and what they are doing. (brightsurf.com)
  • Scientists intend to sequence the entire genetic code of King Richard III, and, among other things, discover who, today, is descended from him. (guardianlv.com)
  • The letter, Single-molecule sequencing of an individual human genome , was published in Nature Biotechnology and details the sequencing of Quake's genome on the Helicos Genetic Analysis System (formerly Heliscope). (politigenomics.com)
  • UK Biobank has granted 10,000 qualified scientists access to its large database of genetic sequences and other medical data, but other organizations with databases have been far more restrictive in giving access. (npr.org)
  • Researchers in Nigeria are participating in an African effort to develop a biobank that reflects the rich genetic diversity of Africa. (npr.org)
  • Award-winning journalist Richard Harris has reported on a wide range of topics in science, medicine and the environment since he joined NPR in 1986. (npr.org)
  • Site-directed mutagenesis further showed that a previously identified nodule-specific AT-rich motif is required for high-level MtENOD11 expression during S. meliloti infection as well as during AM colonization. (apsnet.org)
  • TLRs are membrane glycoproteins and contain leucine rich repeat (LRR) motif in the ectodomain. (biomedcentral.com)
  • The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. (asm.org)
  • Instead, the nonomer UUAUUUAUU is the elemental AU-rich sequence motif that destabilizes mRNA. (asm.org)
  • Taken together, these findings suggest that the nonamer UUAUUUAUU is the minimal AU-rich motif that effectively destabilizes mRNA. (asm.org)
  • Furthermore, analysis of poly(A) shortening rates for ARE-containing mRNAs reveals that the UUAUUUAUU sequence also accelerates mRNA deadenylation and suggests that the UUAUUUAUU motif targets mRNA for rapid deadenylation as an early step in the mRNA decay process. (asm.org)
  • Uribe DJ, Shin YJ, Lau E, Ebbinghaus SW, Sun D (2013) Heterogeneous Nuclear Ribonucleoprotein K Binds to the Cytosine-Rich Sequence of the Hypoxia Inducible Factor 1 Alpha Proximal Promoter that forms a Stable i-motif at Neutral pH. (omicsonline.org)
  • In present study, we demonstrated that the cytosine-rich (C-rich) sequence within the pPu/pPy tract of the HIF-1α promoter is able to form two major intramolecular i-motif structures with 3:3:3 or 3:4:2 folding patterns near physiological pH using circular dichroism, bromine footprinting and site-directed mutational analysis. (omicsonline.org)
  • Taken together, our results demonstrate that the i-motif structures that form within the C-rich sequence of the HIF-1α promoter can form under physiological conditions and that hnRNP K can bind to this C-rich sequence. (omicsonline.org)
  • An approach for amino acid motif searching that can be used for leucine-rich nuclear export signal (NES) prediction. (omictools.com)
  • Is the Subject Area "Sequence motif analysis" applicable to this article? (plos.org)
  • The collection of transcripts associated with GR, identified by immunoprecipitation of GR-mRNA complexes followed by microarray analysis, revealed 479 transcripts that associated with GR. Computational analysis of the primary sequence and secondary structures of these transcripts yielded a GC-rich motif, which was shown to bind to GR in vitro. (jimmunol.org)
  • A GTGGT motif comprised within the GC-rich region, which joins two 100% GC sequences, was frequently deleted, supporting the hypothesis that these deletions could make the region more prone to slippage and pathological expansion. (cdc.gov)
  • We expressed the C-terminal cysteine-rich part of the human MUC5AC mucin in CHO-K1 cells (Chinese-hamster ovary K1 cells) where it formed disulfide-linked dimers in the ER (endoplasmic reticulum). (portlandpress.com)
  • Whole genome sequencing is a way of reading a person's DNA. (le.ac.uk)
  • Whole genome sequencing can provide around 3000 times more data than mitochondrial DNA, providing us with much more information about Richard III, his health, and any bacteria or viruses that may be present within his DNA. (le.ac.uk)
  • Such a region can be approached with next-generation whole-genome sequencing and assembly as if it were an independent small genome. (clemson.edu)
  • So they decided to order up a whole-genome sequencing of the twins. (fastcompany.com)
  • We developed an unbiased assay to screen more than 36,000 computationally predicted nonrepetitive A-to-I sites using massively parallel target capture and DNA sequencing. (sciencemag.org)
  • Here, we report an efficient and unbiased genome-wide approach to identify RNA editing sites that uses tailored target capture followed by massively parallel DNA sequencing. (sciencemag.org)
  • Screening for RNA editing sites using padlock capture and massively parallel DNA sequencing technologies. (sciencemag.org)
  • It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. (nih.gov)
  • Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. (uniprot.org)
  • PGRS was used as the target sequence for the polymerase chain reaction in an attempt to develop a new typing technique. (springer.com)
  • Four oligonucleotides (A-D) of non-regular heteropyrimidine sequences incorporating or not purine residues can form self-associated parallel-stranded (ps) structures at acidic pH. (jbsdonline.com)
  • The determinant sequences of [PSI+] and [URE3] are characterized chiefly by bias for glutamine (Q) and asparagine (N) residues (Table 1 ). (biomedcentral.com)
  • The amino acid sequences of two of these proline-rich peptides comprising 57 and 38 residues were determined by conventional methods. (semanticscholar.org)
  • Most CRM1 cargoes contain the classical NES (also known as leucine-rich NESs), a peptide with 8-15 amino acids, regularly spaced with conserved hydrophobic residues. (omictools.com)
  • the amino-terminal domain shows some homology to a 51-kDa hypothetical antigen of Mycobacterium tuberculosis, while the hydrophilic region contains a high proportion of serine residues, and we have therefore designated the protein serine-rich antigen (Sra). (core.ac.uk)
  • These results together with the simulated three-dimensional structures of the wild-type and mutant sequences suggest that in mutant β subunits with no ATPase activity projection of Thr-156 residues was opposite to that in the wild-type, and that the size and direction of projection of residue 151 are important for the enzyme activity. (elsevier.com)
  • Why are you sequencing Richard III's genome? (le.ac.uk)
  • DNA from other organisms (for example bacteria or viruses) might also be detected alongside Richard III's genome. (le.ac.uk)
  • Will Richard III's sequence really tell us anything meaningful? (le.ac.uk)
  • Richard III's bones revealed that he had scoliosis, an abnormal curvature of the spine. (nbcnews.com)
  • Now, researchers hope to delve further into Richard III's history. (nbcnews.com)
  • The availability of complete mosquito genome sequences has facilitated both large-scale and targeted experiments, which together with hypotheses generated from extensive comparative genomic analyses have driven dramatic advances in the understanding of vector biology. (biomedcentral.com)
  • This finding highlights the importance of using whole organelle genome sequences when conservation decisions are based on molecular information. (fed.us)
  • In genetics , shotgun sequencing is a method used for sequencing long DNA strands. (wikipedia.org)
  • By using automated SML sampling, high-throughput sequencing and unmanned aerial vehicles, we report on the distribution and abundance of pontellid copepods in relation to the unique biophysicochemical signature of the SML. (nature.com)
  • The abundance of repetitive sequences in the Rps1 -k region suggested that the location of this locus is in or near a heterochromatic region. (biomedcentral.com)
  • The exciting part about single molecule sequencing for me was the ability to sequence low abundance transcripts or have phased haplotypes for human sequencing. (blogspot.com)
  • Circles are formed when polymerase, deoxynucleotide triphosphate, and ligase are added, subsequently amplified, and sequenced with an Illumina genome analyzer (Illumina, San Diego, CA). ( B ) Uniformity of target abundance distributions in sequences obtained for all samples. (sciencemag.org)
  • Factors associated with a purine-rich exonic splicing enhancer sequence in Xenopus oocyte nucleus. (nih.gov)
  • Purine-rich exonic splicing enhancers (ESEs) stimulate splicing of the adjacent introns with suboptimal splice sites. (nih.gov)
  • Various experimental procedures, including SELEX experiments and mapping of promoters regulated by EWS-FLI1, have shown that ETS factors bind purine-rich sequences with a GGAA/T core consensus sequence, surrounded by nucleotides that contribute to the specificity of each factor [8] - [11] . (plos.org)
  • Comparison of the deduced amino acid sequences of the CRPs from chlamydial strains indicated that the small CRP is moderately conserved, with 54% identity between C. psittaci 6BC and Chlamydia trachomatis, and the large CRP is highly conserved, with 71% identity between C. psittaci and C. trachomatis and 85% identity between C. psittaci 6BC and Chlamydia pneumoniae. (asm.org)
  • In this study, two TBEV strains: the Norwegian Mandal 2009 (questing nymphs pool) and the Swedish Saringe 2009 (blood-fed nymph) were sequenced and phylogenetically characterized. (diva-portal.org)
  • This prompted us to further sequence and analyze the 3'NCRs of additional Scandinavian TBEV strains and control strains, Hypr and Neudoerfl. (diva-portal.org)
  • Based on this host-dependent oligonucleotide composition, we have proposed strategies for predicting directional changes of virus sequences and for surveilling potentially hazardous strains when introduced into humans from non-human sources. (mdpi.com)
  • NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain. (rupress.org)
  • This new domain is rich in proline, serine, and basic amino acids, and includes three protein kinase C phosphorylation sites and a putative Src homology 3 binding domain. (rupress.org)
  • sequence analysis of the end fused to lacZ revealed an open reading frame with no significant homology to previously published sequences. (core.ac.uk)
  • The sequencing would make the king the first individual of known, historical identity to have a full genome sequence. (nbcnews.com)
  • Shotgun sequencing was one of the precursor technologies that was responsible for enabling full genome sequencing . (wikipedia.org)
  • As the previously rapid climb in cost efficiency brought about by next-generation sequencing plateaus , the failure of single-molecule sequencing to deliver might leave some genomics aficionados despondent about the prospects for their field. (blogspot.com)
  • Using a ChIP-Seq approach to investigate EWS-FLI1-bound DNA sequences in two Ewing cell lines, we show that this chimeric transcription factor preferentially binds two types of sequences including consensus ETS motifs and microsatellite sequences. (plos.org)
  • For the first time, in this work, we have analyzed the different types of sequences belonging to the genome of C . elegans , focusing our investigation on those that show fractal characteristics. (hindawi.com)
  • Since its introduction in 2005 next-generation sequencing (NGS) has fundamentally altered genomics research. (smi-online.co.uk)
  • The strategy was subsequently adopted by The Institute for Genomic Research (TIGR) to sequence the genome of the bacterium Haemophilus influenzae in 1995, [9] and then by Celera Genomics to sequence the Drosophila melanogaster (fruit fly) genome in 2000, [10] and subsequently the human genome. (wikipedia.org)
  • Several lines of evidence, including direct AFM mapping of the label, show that the circular oligonucleotide is stably localized at its target, an A+T rich region. (nebraska.edu)
  • By modifying the conventional SOM, we developed batch-learning SOM (BLSOM), which allowed classification of sequence fragments (e.g., 1 kb) according to phylotypes, solely depending on oligonucleotide composition. (mdpi.com)
  • BLSOM is most suitable for phylogenetic assignment of metagenomic sequences, because fragmental sequences can be clustered according to phylotypes, solely depending on oligonucleotide composition. (mdpi.com)
  • In theory, as long as thermodynamic equilibrium can be assumed, sequence specificity is completely defined by a table containing the (relative) affinity with which the DBD binds to each possible oligonucleotide within the footprint. (elifesciences.org)
  • We specifically targeted this short CpG-rich sequence and developed a quantitative methylation-specific PCR assay suitable for high-throughput analysis. (aacrjournals.org)
  • This difficulty becomes increasingly evident as the number of sequences obtained from a wide range of species, including novel species, dramatically increases (e.g., up to millions of sequences), because of the revolutionized progress of the high-throughput DNA sequencing method. (mdpi.com)
  • However, the sequences that recruit PRC2 in mammalian cells have remained obscure. (nih.gov)
  • Second, we showed that two 1 kb sequence intervals from the Escherichia coli genome with GC-contents comparable to a mammalian CpG island are both capable of recruiting PRC2 when integrated into the ES cell genome. (nih.gov)
  • We have examined the features of AU-rich elements (AREs) that are crucial for their function as determinants of mRNA instability in mammalian cells by testing the ability of various mutant c-fos AREs and synthetic AREs to direct rapid mRNA deadenylation and decay when inserted within the 3' UTR of the normally stable beta-globin mRNA. (asm.org)
  • Glycine-rich regions are proposed to be involved in protein-protein interactions in some mammalian protein families. (ufrgs.br)
  • GRSDB: a database of quadruplex forming G-rich sequences in alternatively processed mammalian pre-mRNA sequences. (elsevier.com)
  • In 2012, the first two methods for m6A sequencing came out that enabled transcriptome-wide profile of m6A in mammalian cells. (wikipedia.org)
  • The polymorphic GC-rich repetitive sequence (PGRS) found on the chromosome of Mycobacterium tuberculosis was characterized by means of mapping, cloning and sequencing. (springer.com)
  • Mycobacterium tuberculosis cultures were subjected to DNA fingerprinting with IS6110- and polymorphic GC-rich sequence (PGRS)-containing probes. (sun.ac.za)
  • PGRS was present in at least 26 loci and consisted of many tandem repeats of the consensus sequence CGGCGGCAA. (springer.com)
  • Primary structure information and predicted secondary structure elements of the protein indicate that PYBP contains four sequence repeats. (pasteur.fr)
  • Most methods have been adapted and optimized for mRNA molecules, except for modified bisulfite sequencing for profiling 5-methylcytidine which was optimized for tRNAs and rRNAs. (wikipedia.org)
  • These results indicate that cytoplasmic GR interacts with a subset of mRNA through specific sequences and can regulate turnover rates, suggesting a novel posttranscriptional role for GR as an RNA-binding protein. (jimmunol.org)
  • The Rps1 -k region is primarily composed of repetitive sequences. (biomedcentral.com)
  • In epitranscriptomic sequencing, most methods focus on either (1) enrichment and purification of the modified RNA molecules before running on the RNA sequencer, or (2) improving or modifying bioinformatics analysis pipelines to call the modification peaks. (wikipedia.org)
  • This sequence is also found in the human MUC2 mucin, previously shown to be cleaved at the same site by a slow, non-enzymatic process triggered by a pH below 6 [Lidell, Johansson and Hansson (2003) J. Biol. (portlandpress.com)
  • The bottom line is that three researchers sequenced a human genome in four Helicos runs. (politigenomics.com)
  • What you can take away from this is that you may be able to sequence a human genome with three people, but it takes a village of bioinformaticians to do the sequence data justice. (politigenomics.com)
  • This paper sets the bar pretty low for other third-generation sequencing contenders: it appears that formal entry into the human genome sequencing race merely requires generating a genome sequence of the standard that second-generation sequencers were achieving in early 2008, at the same price that they're charging right now. (politigenomics.com)
  • For six eukaryotic proteomes (budding yeast, fission yeast, nematode worm, fruit fly, human and Arabidopsis ), we have used this formalism to analyze the prevalence of Q- and N-rich regions in the context of other biases. (biomedcentral.com)
  • In general, N-rich regions are rarer than Q-rich regions in the eukaryotic proteomes, most notably so in the human proteome. (biomedcentral.com)
  • Isolation and amino acid sequences of proline-rich peptides of human whole saliva. (semanticscholar.org)
  • To date, most studies have used short read sequencing technologies to interrogate the transcriptome complexity in human brains. (frontiersin.org)
  • however, one clone of 1991/4944 contained an (A) 3C(A)11 poly(A) sequence, demonstrating that quasispecies with longer poly(A) could be present in human isolates. (diva-portal.org)
  • Even so, current methods have failed to isolate or assemble reliable sequence for approximately 1% of the ( euchromatic ) human genome, as of 2004. (wikipedia.org)
  • The first published description of the use of paired ends was in 1990 [6] as part of the sequencing of the human HGPRT locus, although the use of paired ends was limited to closing gaps after the application of a traditional shotgun sequencing approach. (wikipedia.org)
  • When the first human genome sequence was finished in 2003, it quickly became clear that its seemingly unending stream of letters was not enough to comprehend what makes people tick. (alzforum.org)
  • 3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence variation and plasma viral load (VL), while considering human and viral population structure. (elifesciences.org)
  • Computational techniques were then used to search for links between variants in the human DNA sequences and variants in the viral sequences. (elifesciences.org)
  • found that SNPs within the human DNA sequences in their study were linked to variations in 48 amino acids in HIV. (elifesciences.org)
  • It is striking that the enzyme with the ras mutation (differing in three amino acids from the β sequence) had about half the membrane ATPase activity of the wild-type. (elsevier.com)
  • A 1.8-kbp HindIII fragment was subcloned from one of the cosmids and sequenced. (core.ac.uk)
  • They achieved this by decreasing fragment size and employing a ligation-based strand-specific library preparation protocol capturing both ends of the fragmented RNA, ensuring that the methylated position is within the sequenced fragment. (wikipedia.org)
  • As sequencing projects began to take on longer and more complicated DNA sequences, multiple groups began to realize that useful information could be obtained by sequencing both ends of a fragment of DNA. (wikipedia.org)
  • Although sequencing both ends of the same fragment and keeping track of the paired data was more cumbersome than sequencing a single end of two distinct fragments, the knowledge that the two sequences were oriented in opposite directions and were about the length of a fragment apart from each other was valuable in reconstructing the sequence of the original target fragment. (wikipedia.org)
  • [7] At the time, there was community consensus that the optimal fragment length for pairwise end sequencing would be three times the sequence read length. (wikipedia.org)
  • Bioinformatic analysis predicted that A-rich sequences are generally associated with minimal local RNA structures. (pubmedcentralcanada.ca)
  • Rick Durrett received his Ph.D. in operations research from Stanford University in 1976. (buecher.de)
  • What will this data tell us about Richard III? (le.ac.uk)
  • The Broad team sequences each of those barcodes, generating data that later allows users to determine where the sequencing reads originated on the bead array. (brightsurf.com)
  • Our data showed that codon modification of HIV-1 sequences led to a suppression of virus infectivity by 5-100-fold, and this defect does not correlate with, viral entry, viral protein expression levels, viral protein profiles or virion packaging of genomic RNA. (pubmedcentralcanada.ca)
  • My lab is focused on developing and applying technology to enable a full understanding of DNA sequence data at the scale it is now routinely produced. (searlescholars.net)
  • For many projects, the ability to generate sequence data is not limiting. (searlescholars.net)
  • With the remarkable increase of genomic sequence data of microorganisms, novel tools are needed for comprehensive analyses of the big sequence data available. (mdpi.com)
  • Our data confirmed the association between deletions within GC-rich region and the GGGGCC expansion in Italian and Turkish cases, although we did not confirm a role of the GTGGT element deletion. (cdc.gov)
  • These structures are the first known i-motifs that form at neutral pH, with a transitional pH at 6.9, which have been discovered to form within the proximal promoter sequence of oncogenes. (omicsonline.org)
  • Promoter analysis revealed that a 9-bp sequence, GGGGCGGGG, representing the consensus Sp1-binding site between -109 and -100 of the TGF-β1 promoter, was the major target for E6-mediated transactivation. (northwestern.edu)
  • Previous studies have shown that the adenovirus 12S E1A oncoprotein represses the TGF-β1 promoter by targeting an adjacent (-90 to -81) but different GC-rich sequence (TGGGTGGGG). (northwestern.edu)
  • These studies provide evidence that variant GC-rich promoter elements are not functionally identical and are differentially regulated by the DNA virus oncoproteins. (northwestern.edu)
  • Based on this causal demonstration and prior genomic analyses, we hypothesized that large GC-rich elements depleted of activating transcription factor motifs mediate PRC2 recruitment in mammals. (nih.gov)
  • The new method utilizes known LRR structures to recognize and align new LRR motifs in TLRs and incorporates multiple sequence alignments and secondary structure predictions. (biomedcentral.com)
  • RNA structures are primarily determined by the nucleotide contents of the RNA sequences. (pubmedcentralcanada.ca)
  • Parallel Structures Formed by T,C-rich Sequences. (jbsdonline.com)
  • comparisons of the primary as well as tertiary structures of pseudo-p20 domains with their presumably proteolytically active homologs suggest that differences in their amino acid sequences have no influence on the overall structures. (frontiersin.org)
  • Since the RNA strands are randomly chopped up, the m6A site should, in principle, lie somewhere in the center of the regions to which sequence reads align. (wikipedia.org)
  • In shotgun sequencing, [1] [2] DNA is broken up randomly into numerous small segments, which are sequenced using the chain termination method to obtain reads . (wikipedia.org)
  • Multiple overlapping reads for the target DNA are obtained by performing several rounds of this fragmentation and sequencing. (wikipedia.org)
  • Computer programs then use the overlapping ends of different reads to assemble them into a continuous sequence. (wikipedia.org)
  • In this extremely simplified example, none of the reads cover the full length of the original sequence, but the four reads can be assembled into the original sequence using the overlap of their ends to align and order them. (wikipedia.org)
  • Many overlapping reads for each segment of the original DNA are necessary to overcome these difficulties and accurately assemble the sequence. (wikipedia.org)
  • that is, each base in the final sequence was present on average in 12 different reads. (wikipedia.org)
  • Collins DM, Stephens DM (1991) Identification of an insertion sequence, IS 1081 , in Mycobacterium bovis . (springer.com)
  • The first theoretical description of a pure pairwise end sequencing strategy, assuming fragments of constant length, was in 1991. (wikipedia.org)
  • A method is provided for amplifying and detecting specific GC-rich nucleic acid sequences contained in a nucleic acid or in a mixture of nucleic acids, which includes treating a separate nucleic acid containing the specific sequence with a molar excess of primers and a polymerase and extending the primers in the presence of dATP, dCTP, TTP, and an analogue of dGTP. (google.com)
  • To discover rare variants with large effect size and to evaluate their role in the etiopathophysiology of SCZ and ASD, we sequenced the RTN4R coding exons with a sample comprising 370 SCZ and 192 ASD patients, and association analysis using a large number of unrelated individuals (1716 SCZ, 382 ASD and 4009 controls). (nature.com)
  • The range of sequence variants differ between Sindh, the Punjab and northwestern India. (mdpi.com)
  • Additionally, electrophoretic mobility shift assays (EMSA) combined with bromine footprinting revealed that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is able to bind to the unfolded state of C-rich sequence in a sequence specific manner. (omicsonline.org)
  • Recent technological advances have made it possible to identify where transcription factors can bind within DNA sequences. (elifesciences.org)
  • Using the minimum tiling path as a guide, specific BAC clones representing the prioritized genomic interval are selected, pooled, and used to prepare a sequencing library. (clemson.edu)
  • HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. (elifesciences.org)
  • Methylation analyses have been conducted using conventional methodologies such as COBRA, direct sequencing, or methylation-specific PCR of the bisulfite-treated DNA. (aacrjournals.org)
  • Here the analyses of sequences of three overlapping BAC clones containing the 184,111 bp Rps1 -k region are reported. (biomedcentral.com)
  • A shotgun sequencing strategy was applied in sequencing the BAC contig. (biomedcentral.com)
  • primer walking (or "chromosome walking") which progresses through the entire strand piece by piece, and shotgun sequencing, which is a faster but more complex process that uses random fragments. (wikipedia.org)
  • The first genome sequenced by shotgun sequencing was that of cauliflower mosaic virus , published in 1981. (wikipedia.org)
  • Broader application benefited from pairwise end sequencing , known colloquially as double-barrel shotgun sequencing . (wikipedia.org)
  • The GGGGCC repeat is contiguous with another GC-rich region. (cdc.gov)
  • Further studies will be therefore necessary to assess the causal relationships between contiguous deletions of the GC-rich region and the GGGGCC expansion. (cdc.gov)
  • These include metagenomics to compare different disease states or patient variablility , genome sequencing of model and pathogenic species or ELT compound library screening techniques. (smi-online.co.uk)
  • Further, by comparing the genome sequence of the alligator to other species for which the molecular basis of sex-determination is more completely understood, we hope to understand how this process evolves. (searlescholars.net)
  • Additionally, the lack of sequence variation within the only coding sequence of CLCuMB suggests that the betasatellite is not involved in resistance breaking which became a problem after 2001 in the Punjab and subsequently also in northwestern India. (mdpi.com)
  • We discuss how this relates to prion-determinant domains (that is, regions of the prion sequences that are necessary for the prion phenomenon). (biomedcentral.com)
  • Motivated by the fact that prion-determinant sequences correspond to LPSs, we examine LPSs for Q and N biases in the context of single-residue biases for all residue types, in all six proteomes. (biomedcentral.com)
  • The occurrence of quasi-repetitive glycine-rich peptides has been reported in different organisms. (ufrgs.br)
  • The only common feature among all different GRPs is the presence of glycine-rich repeat domains. (ufrgs.br)
  • First, we are working on developing and evaluating assembly algorithms for next-generation sequencing. (searlescholars.net)
  • This webinar will discuss a validation study for a next-generation sequencing (NGS) assay for hematological malignancies (e.g., acute myeloid leukemia, acute lymphocytic leukemia, myelodysplastic syndrome, and myeloproliferative neoplasms). (genomeweb.com)
  • In this interview, Professor John Rossen talks about next-generation sequencing and it's implications for the diagnosis of disease. (news-medical.net)
  • Besides learning that King Richard III was a hunchback, as William Shakespeare and other sources wrote about the last Plantagenet king, the British scientists have also discovered that he died from having his head cleaved with a sharp instrument, possibly a halberd or a sword, and that he had roundworms. (guardianlv.com)
  • Even if the DNA is too fragmented to get a complete genome map, the information that the British scientists have learned and are learning about the skeleton of King Richard III will prove to be invaluable. (guardianlv.com)
  • British scientists have not discovered that Richard III was a hunchback, though some benighted individuals have said so. (guardianlv.com)
  • The guanine-rich sequence of this pPu/pPy tract has been known to be structurally dynamic, easily forming a G-quadruplex structure with a 1:6:1 folding pattern. (omicsonline.org)
  • However, it inevitably depends on alignments of sequences, which is potentially error-prone and troublesome, especially for distantly related sequences. (mdpi.com)