AT-Hook Motifs: DNA-binding motifs, first described in one of the HMGA PROTEINS: HMG-I(Y) PROTEIN. They consist of positively charged sequences of nine amino acids centered on the invariant tripeptide glycine-arginine-proline. They act to fasten the protein to an AT RICH SEQUENCE in the DNA.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Motifs: Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Nucleotide Motifs: Commonly observed BASE SEQUENCE or nucleotide structural components which can be represented by a CONSENSUS SEQUENCE or a SEQUENCE LOGO.Flagella: A whiplike motility appendage present on the surface cells. Prokaryote flagella are composed of a protein called FLAGELLIN. Bacteria can have a single flagellum, a tuft at one pole, or multiple flagella covering the entire surface. In eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella have the same basic structure as CILIA but are longer in proportion to the cell bearing them and present in much smaller numbers. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Conserved Sequence: A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Thermography: Imaging the temperatures in a material, or in the body or an organ. Imaging is based on self-emanating infrared radiation (HEAT WAVES), or on changes in properties of the material or tissue that vary with temperature, such as ELASTICITY; MAGNETIC FIELD; or LUMINESCENCE.Body Temperature: The measure of the level of heat of a human or animal.Amino Acids, Aromatic: Amino acids containing an aromatic side chain.Skin Temperature: The TEMPERATURE at the outer surface of the body.Spectrometry, Fluorescence: Measurement of the intensity and quality of fluorescence.Jewelry: Objects of precious metal usually containing gems and worn to enhance personal appearance. Health concerns include possible contamination from lead content or bacteria.Body Piercing: The perforation of an anatomical region for the wearing of jewelry.Designer Drugs: Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.Foreign Bodies: Inanimate objects that become enclosed in the body.Spectrometry, X-Ray Emission: The spectrometric analysis of fluorescent X-RAYS, i.e. X-rays emitted after bombarding matter with high energy particles such as PROTONS; ELECTRONS; or higher energy X-rays. Identification of ELEMENTS by this technique is based on the specific type of X-rays that are emitted which are characteristic of the specific elements in the material being analyzed. The characteristic X-rays are distinguished and/or quantified by either wavelength dispersive or energy dispersive methods.Blepharoptosis: Drooping of the upper lid due to deficient development or paralysis of the levator palpebrae muscle.Synkinesis: An involuntary movement accompanying a volitional movement. It often refers to facial movements that accompany FACIAL PARALYSIS.Chiroptera: Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.Hibernation: The dormant state in which some warm-blooded animal species pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs.Echolocation: An auditory orientation mechanism involving the emission of high frequency sounds which are reflected back to the emitter (animal).Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Lyssavirus: A genus of the family RHABDOVIRIDAE that includes RABIES VIRUS and other rabies-like viruses.Peptide Termination Factors: Proteins that are involved in the peptide chain termination reaction (PEPTIDE CHAIN TERMINATION, TRANSLATIONAL) on RIBOSOMES. They include codon-specific class-I release factors, which recognize stop signals (TERMINATOR CODON) in the MESSENGER RNA; and codon-nonspecific class-II release factors.Ageusia: Complete or severe loss of the subjective sense of taste, frequently accompanied by OLFACTION DISORDERS.Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.Mercury PoisoningSurgical Tape: A flat, flexible strip of material used to cover or fasten together damaged tissue.Mercury Compounds: Inorganic compounds that contain mercury as an integral part of the molecule.Music: Sound that expresses emotion through rhythm, melody, and harmony.Vascular Access Devices: Devices to be inserted into veins or arteries for the purpose of carrying fluids into or from a peripheral or central vascular location. They may include component parts such as catheters, ports, reservoirs, and valves. They may be left in place temporarily for therapeutic or diagnostic purposes.Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.Baths: The immersion or washing of the body or any of its parts in water or other medium for cleansing or medical treatment. It includes bathing for personal hygiene as well as for medical purposes with the addition of therapeutic agents, such as alkalines, antiseptics, oil, etc.Toilet Facilities: Facilities provided for human excretion, often with accompanying handwashing facilities.Sanitary Engineering: A branch of engineering concerned with the design, construction, and maintenance of environmental facilities conducive to public health, such as water supply and waste disposal.Metallurgy: The science, art, or technology dealing with processes involved in the separation of metals from their ores, the technique of making or compounding the alloys, the techniques of working or heat-treating metals, and the mining of metals. It includes industrial metallurgy as well as metallurgical techniques employed in the preparation and working of metals used in dentistry, with special reference to orthodontic and prosthodontic appliances. (From Jablonski, Dictionary of Dentistry, 1992, p494)Housekeeping, Hospital: Hospital department which manages and provides the required housekeeping functions in all areas of the hospital.IcelandArctic Regions: The Arctic Ocean and the lands in it and adjacent to it. It includes Point Barrow, Alaska, most of the Franklin District in Canada, two thirds of Greenland, Svalbard, Franz Josef Land, Lapland, Novaya Zemlya, and Northern Siberia. (Webster's New Geographical Dictionary, 1988, p66)Flatfishes: Common name for the order Pleuronectiformes. A very distinctive group in that during development they become asymmetrical, i.e., one eye migrates to lie adjacent to the other. They swim on the eyeless side. FLOUNDER, sole, and turbot, along with several others, are included in this order.Mars: The fourth planet in order from the sun. Its two natural satellites are Deimos and Phobos. It is one of the four inner or terrestrial planets of the solar system.Nursing Homes: Facilities which provide nursing supervision and limited medical care to persons who do not require hospitalization.History, 16th Century: Time period from 1501 through 1600 of the common era.History, 17th Century: Time period from 1601 through 1700 of the common era.

Characterisation of a cluster of genes encoding Theileria annulata AT hook DNA-binding proteins and evidence for localisation to the host cell nucleus. (1/23)

Infection of bovine leukocytes by the apicomplexan parasite Theileria annulata results in alteration of host cell gene expression and stimulation of host cell proliferation. At present, the parasite-derived factors involved in these processes are unknown. Recently, we described the characterisation of a parasite gene (TashAT2), whose polypeptide product bears AT hook DNA-binding motifs and may be transported from the parasite to the host nucleus. We now describe the isolation of a further two genes (TashAT1 and TashAT3) that are very closely related to TashAT2. All three TashAT genes are located together in a tight cluster, interspersed by two further small open reading frames, all facing head to tail. TashAT2 was shown to be expressed in all T. annulata cell lines examined, whereas TashAT1 and TashAT3 were expressed in the sporozoite stage of the parasite, and also in infected cell lines, where their expression was found to vary between different cell lines. Evidence for transport was provided by antisera raised against TashAT1 and TashAT3 that reacted with the host nucleus of T. annulata-infected cells. Reactivity was particularly strong against the host nuclei of the T. annulata-infected cloned cell line D7B12, which is attenuated for differentiation. A polypeptide in the size range predicted for TashAT3 was preferentially detected in host enriched D7B12 nuclear extracts. DNA-binding analysis demonstrated that fusion proteins containing the AT hook region of either TashAT1 or TashAT2 bound preferentially to AT rich DNA.  (+info)

Synthesis of signals for de novo DNA methylation in Neurospora crassa. (2/23)

Most 5-methylcytosine in Neurospora crassa occurs in A:T-rich sequences high in TpA dinucleotides, hallmarks of repeat-induced point mutation. To investigate how such sequences induce methylation, we developed a sensitive in vivo system. Tests of various 25- to 100-bp synthetic DNA sequences revealed that both T and A residues were required on a given strand to induce appreciable methylation. Segments composed of (TAAA)(n) or (TTAA)(n) were the most potent signals; 25-mers induced robust methylation at the special test site, and a 75-mer induced methylation elsewhere. G:C base pairs inhibited methylation, and cytosines 5' of ApT dinucleotides were particularly inhibitory. Weak signals could be strengthened by extending their lengths. A:T tracts as short as two were found to cooperate to induce methylation. Distamycin, which, like the AT-hook DNA binding motif found in proteins such as mammalian HMG-I, binds to the minor groove of A:T-rich sequences, suppressed DNA methylation and gene silencing. We also found a correlation between the strength of methylation signals and their binding to an AT-hook protein (HMG-I) and to activities in a Neurospora extract. We propose that de novo DNA methylation in Neurospora cells is triggered by cooperative recognition of the minor groove of multiple short A:T tracts. Similarities between sequences subjected to repeat-induced point mutation in Neurospora crassa and A:T-rich repeated sequences in heterochromatin in other organisms suggest that related mechanisms control silent chromatin in fungi, plants, and animals.  (+info)

The Stigmatella aurantiaca homolog of Myxococcus xanthus high-mobility-group A-type transcription factor CarD: insights into the functional modules of CarD and their distribution in bacteria. (3/23)

Transcriptional factor CarD is the only reported prokaryotic analog of eukaryotic high-mobility-group A (HMGA) proteins, in that it has contiguous acidic and AT hook DNA-binding segments and multifunctional roles in Myxococcus xanthus carotenogenesis and fruiting body formation. HMGA proteins are small, randomly structured, nonhistone, nuclear architectural factors that remodel DNA and chromatin structure. Here we report on a second AT hook protein, CarD(Sa), that is very similar to CarD and that occurs in the bacterium Stigmatella aurantiaca. CarD(Sa) has a C-terminal HMGA-like domain with three AT hooks and a highly acidic adjacent region with one predicted casein kinase II (CKII) phosphorylation site, compared to the four AT hooks and five CKII sites in CarD. Both proteins have a nearly identical 180-residue N-terminal segment that is absent in HMGA proteins. In vitro, CarD(Sa) exhibits the specific minor-groove binding to appropriately spaced AT-rich DNA that is characteristic of CarD or HMGA proteins, and it is also phosphorylated by CKII. In vivo, CarD(Sa) or a variant without the single CKII phosphorylation site can replace CarD in M. xanthus carotenogenesis and fruiting body formation. These two cellular processes absolutely require that the highly conserved N-terminal domain be present. Thus, three AT hooks are sufficient, the N-terminal domain is essential, and phosphorylation in the acidic region by a CKII-type kinase can be dispensed with for CarD function in M. xanthus carotenogenesis and fruiting body development. Whereas a number of hypothetical proteins homologous to the N-terminal region occur in a diverse array of bacterial species, eukaryotic HMGA-type domains appear to be confined primarily to myxobacteria.  (+info)

A Theileria annulata DNA binding protein localized to the host cell nucleus alters the phenotype of a bovine macrophage cell line. (4/23)

The apicomplexan parasite Theileria annulata is the only intracellular eukaryote that is known to induce the proliferation of mammalian cells. However, as the parasite undergoes stage differentiation, host cell proliferation is inhibited, and the leukocyte is eventually destroyed. We have isolated a parasite gene (SuAT1) encoding an AT hook DNA binding polypeptide that has a predicted signal peptide, PEST motifs, nuclear localization signals, and domains which indicate interaction with regulatory components of the higher eukaryotic cell cycle. The polypeptide is localized to the nuclei of macroschizont-infected cells and was detected at significant levels in cells that were undergoing parasite stage differentiation. Transfection of an uninfected transformed bovine macrophage cell line, BoMac, demonstrated that SuAT1 can modulate cellular morphology and alter the expression pattern of a cytoskeletal polypeptide in a manner similar to that found during the infection of leukocytes by the parasite. Our findings indicate that Theileria parasite molecules that are transported to the leukocyte nucleus have the potential to modulate the phenotype of infected cells.  (+info)

The herpesvirus saimiri open reading frame (ORF) 50 (Rta) protein contains an at hook required for binding to the ORF 50 response element in delayed-early promoters. (5/23)

The herpesvirus saimiri open reading frame (ORF) 50 encodes two proteins, which activate transcription directly, following interactions with delayed-early (DE) promoters containing a specific motif. In this report, we demonstrate that ORF 50 contains a DNA binding domain that has homology to an AT hook DNA binding motif. Deletion analysis of this domain reduces ORF 50-mediated transactivation of the DE ORF 6 and ORF 57 promoters by 100 and 90%, respectively. Furthermore, gel retardation experiments demonstrated that the AT hook motif is required for binding the ORF 50 response element in the promoters of DE genes. Single site-directed mutagenesis of the AT hook revealed that mutation of the glycine residue at position 408 to an alanine reduces ORF 50 transactivation of the ORF 57 promoter by 40%. Moreover, the mutation of multiple basic residues in conjunction with the glycine residue within the core element of the AT hook abolishes ORF 50-mediated transactivation. In addition, p50GFPDeltaAT-hook is capable of functioning as a trans-dominant mutant, leading to a reduction in virus production of approximately 50% compared to that for wild-type ORF 50.  (+info)

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo. (6/23)

Lens epithelium-derived growth factor p75 (LEDGF/p75) is a DNA-binding, transcriptional co-activator that participates in HIV-1 integration site targeting. Using complementary approaches, we determined the mechanisms of LEDGF/p75 DNA-binding in vitro and chromatin-association in living cells. The binding of highly-purified, recombinant protein was assayed by surface plasmon resonance (SPR) and electrophoretic mobility gel shift. Neither assay revealed evidence for sequence-specific DNA-binding. Residues 146-197 spanning the nuclear localization signal (NLS) and two AT-hook motifs mediated non-specific DNA-binding, and DNA-binding deficient mutants retained the ability to efficiently stimulate HIV-1 integrase activity in vitro. Chromatin-association was assessed by visualizing the localization of EGFP fusion proteins in interphase and mitotic cells. Although a conserved N-terminal PWWP domain was not required for binding to condensed mitotic chromosomes, its deletion subtly affected the nucleoplasmic distribution of the protein during interphase. A dual AT-hook mutant associated normally with chromatin, yet when the mutations were combined with NLS changes or deletion of the PWWP domain, chromatin-binding function was lost. As the PWWP domain did not readily bind free DNA in vitro, our results indicate that chromatin-association is primarily affected through DNA-binding, with the PWWP domain likely contributing a protein interaction to the overall affinity of LEDGF/p75 for human chromatin.  (+info)

DNA binding properties of TAF1 isoforms with two AT-hooks. (7/23)

TATA-binding protein-associated factor 1 (TAF1) is an essential component of the general transcription factor IID (TFIID), which nucleates assembly of the preinitiation complex for transcription by RNA polymerase II. TATA-binding protein and TAF1.TAF2 heterodimers are the only components of TFIID shown to bind specific DNA sequences (the TATA box and initiator, respectively), raising the question of how TFIID localizes to gene promoters that lack binding sites for these proteins. Here we demonstrate that Drosophila TAF1 protein isoforms TAF1-2 and TAF1-4 directly bind DNA independently of TAF2. DNA binding by TAF1 isoforms is mediated by cooperative interactions of two identical AT-hook motifs, one of which is encoded by an alternatively spliced exon. Electrophoretic mobility shift assays revealed that TAF1-2 bound the minor groove of adenine-thymine-rich DNA with a preference for the sequence AAT. Alanine-scanning mutagenesis of the alternatively spliced AT-hook indicated that Lys and Arg residues made essential DNA contacts, whereas Gly and Pro residues within the Arg-Gly-Arg-Pro core sequence were less important for DNA binding, suggesting that AT-hooks are more divergent than previously predicted. TAF1-2 bound with variable affinity to the transcription start site of several Drosophila genes, and binding to the hsp70 promoter was reduced by mutation of a single base pair at the transcription start site. Collectively, these data indicate that AT-hooks serve to anchor TAF1 isoforms to the minor groove of adenine-thymine-rich Drosophila gene promoters and suggest a model in which regulated expression of TAF1 isoforms by alternative splicing contributes to gene-specific transcription.  (+info)

Pituitary transcription factor Prop-1 stimulates porcine pituitary glycoprotein hormone alpha subunit gene expression. (8/23)

Recently, we have reported that a Prophet of Pit-1 homeodomain factor, Prop-1, is a novel transcription factor for the porcine follicle-stimulating hormone beta subunit (FSHbeta) gene. This study subsequently aimed to examine the role of Prop-1 in the gene expression of two other porcine gonadotropin subunits, pituitary glycoprotein hormone alpha subunit (alphaGSU), and luteinizing hormone beta subunit (LHbeta). A series of deletion mutants of the porcine alphaGSU (up to -1059 bp) and LHbeta (up to -1277 bp) promoters were constructed in the reporter vector, fused with the secreted alkaline phosphatase gene (pSEAP2-Basic). Transient transfection studies using GH3 cells were carried out to estimate the activation of the porcine alphaGSU and LHbeta promoters by Prop-1, which was found to activate the alphaGSU promoter of -1059/+12 bp up to 11.7-fold but not the LHbeta promoter. Electrophoretic mobility shift assay and DNase I footprinting analysis revealed that Prop-1 binds to six positions, -1038/-1026, -942/-928, -495/-479, -338/-326, -153/-146, and -131/-124 bp, that comprise the A/T cluster. Oligonucleotides of six Prop-1 binding sites were directly connected to the minimum promoter of alphaGSU, fused in the pSEAP2-Basic vector, followed by transfecting GH3 cells to determine the cis-acting activity. Finally, we concluded that at least five Prop-1 binding sites are the cis-acting elements for alphaGSU gene expression. The present results revealed a notable feature of the proximal region, where three Prop-1-binding sites are close to and/or overlap the pituitary glycoprotein hormone basal element, GATA-binding element, and junctional regulatory element. To our knowledge, this is the first demonstration of the role of Prop-1 in the regulation of alphaGSU gene expression. These results, taken together with our previous finding that Prop-1 is a transcription factor for FSHbeta gene, confirm that Prop-1 modulates the synthesis of FSH at the transcriptional level. On the other hand, the defects of Prop-1 are known to cause dwarfism and combined pituitary hormone deficiency accompanying hypogonadism. Accordingly, the present observations provide a novel view to understand the hypogonadism caused by Prop-1 defects at the molecular level through the regulatory mechanism of alphaGSU and FSHbeta gene expressions.  (+info)

This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008 ...
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation ...
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Complete information for AHCTF1P1 gene (Pseudogene), AT-Hook Containing Transcription Factor 1 Pseudogene 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Upstream molecules of p38α that directly lead to the phosphorylation of p38α include enzymes such as MKK6, MKK3 and MKK4 (Cuenda et al., 1996; Derijard et al., 1995; Han et al., 1996; Kayali et al., 2000; Moriguchi et al., 1996; Raingeaud et al., 1996), and the non-enzymatic adapter, TAB1 (Ge et al., 2002). Although activation and regulation of the p38α MAPK pathway has been well established, some processes are still not fully understood. To highlight the p38α signaling pathway, emphasis should be placed on the identification of p38α-interacting proteins. In this report, we characterized a p38α-interacting protein, NP60.. NP60 is a newly identified protein with several well-characterized motifs, such as an NLS, PWWP, AT hook and an NAD-binding region (Fig. 1). It localizes only in the nuclei (Fig. 2) and interacts specifically with p38α (Fig. 3). PWWP has been considered a domain-mediating protein-protein interaction (Stec et al., 2000). It has also been identified to mediate DNA-protein ...
... Systematic (IUPAC) name N-[(3S,4R)-1-phenethyl-3-prop-2-enylpiperidin-4-yl]-N-phenylpropanamide Identifiers CAS number
The Toxoplasma Blog features the latest news regarding this protozoan parasite, including information about relevant scientific meetings and job opportunities. This blog is maintained by Bill Sullivan (wjsulliv[at]iu[dot]edu ...
And on that one night when you do brave the weather and you do get away with it you are inundated with the Large Yellow Underwings and Flounced Rustics of this world looking all the worse as theres nothing to put the cheer back,but today,today was different when I was blessed with that monstrous Red Underwing,not perfect but then he has traveled a long way to get here. I have seen them at Hook and Odiham in the past but this one kept going thank goodness,so it a new for garden species ...
(Z)-2-Methoxy-4-(prop-1-enyl)phenol/ACM5912867 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Cas number 2489-86-3 Cas 2489-86-3 Cas #2489-86-3 Chemicals Chemicals 3-A-Naphthylpropene, 1-prop-2-Enylnaphthalene, 1-Allylnaphthalene, Allyl Naphthalene, Allylnaphthalene
Lim, Pyung Ok, Kim, Yumi, Breeze, Emily, Koo, Ja Choon, Woo, Hye Ryun, Ryu, Jong Sang, Park, Don Ha, Beynon, Jim, Tabrett, Alex, Buchanan-Wollaston, Vicky and Nam, Hong Gil. (2007) Overexpression of a chromatin architecture-controlling AT-hook protein extends leaf longevity and increases the post-harvest storage life of plants. PLANT JOURNAL, 52 (6). pp. 1140-1153. ISSN 0960-7412 Buchanan-Wollaston, Vicky, Harrison, Elizabeth and Breeze, Emily (2007) Elucidating signaling pathways that control Arabidopsis leaf senescence. In: Annual Main Meeting of the Society for Experimental Biology, Glasgow, Scotland, March 31 - April 4, 2007. Published in: Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology, Vol.146 (No.4 Supplement). S53-S54. ...
Michigan Stone Dry Fly: HOOK: Mustad 94842 #16 WING: Deer Body Hair BODY: Yellow Rabbit Fur (I Used Substitute) HACKLE: Grizzly at Hook Bend and in Front of ...
A baby orca is now at home swimming around a 6m wide Para pool on a council reserve overlooking the Tauranga harbour. On Wednesday
/CNW/ - Orca Exploration Group Inc. (Orca or the Company) announces its results for the quarter and six months ended 30 June 2014. Highlights The highest...
Petrus Aged Pale is a Belgian Pale Ale style beer brewed by De Brabandere in Bavikhove, Belgium. 4.07 average with 2491 ratings, reviews and opinions.
Petrus Aged Pale is a Belgian Pale Ale style beer brewed by De Brabandere in Bavikhove, Belgium. 4.07 average with 2491 ratings, reviews and opinions.
The DNase I accessibility and chromatin organization of genes within the nucleus do correlate to their transcriptional activity. Here, we show that both serum starvation and overexpression of Tip5, a key regulator of ribosomal RNA gene (rDNA) repression, dictate DNase I accessibility, facilitate the association of rDNA with the nuclear matrix and thus regulate large-scale rDNA chromatin organization. Tip5 contains four AT-hooks and a TAM (Tip5/ARBP/MBD) domain, which were proposed to bind matrix-attachment regions (MARs) of the genome. Remarkably, the TAM domain of Tip5 functions as nucleolar localization and nuclear matrix targeting module, whereas AT-hooks do not mediate association with the nuclear matrix, but they are required for nucleolar targeting. These findings suggest a dual role for Tip5s AT-hooks and TAM domain, targeting the nucleolus and anchoring to the nuclear matrix, and suggest a function for Tip5 in the regulation of higher-order rDNA chromatin structure. ...
0077] FIG. 59 depicts the identification of derivatives with high potency and selectivity in the T. gondii-CpIMPDH model. Panel A shows the EC50 for a selection of compounds assayed in the T. gondii-CpIMPDH parasite model and demonstrates a range in compound selectivity and potency. Compounds were assayed in triplicate and growth inhibition was calculated on a day during the exponential phase of growth, by normalization to wells receiving DMSO alone. The EC50 calculation was performed as described in FIG. 63. Compounds A82, A89, A90, A92, A102, A103, A105, and A110 were selected for rescreening and the mean for at least 2 replicate experiments are shown. These compounds were then tested for inhibition of C. parvum (panel B) and host cell growth (panel C). For panel B, percent C. parvum growth was determined using the high-content imaging assay, with compound at 12.5 μM and 25 μM. The ratio of FITC-VVL labeled C. parvum parasites to DAPI labeled HCT-8 host cell nuclei was used to standardize ...
Our long-range goal is to elucidate the chromatin regulatory factors that establish and maintain CD8+ cytotoxic T lymphocyte (CTL) differentiation in the contex...
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for (2,5-dimethylphenyl) 3-(4-methoxyphenyl)prop-2-enoate (CAS No. 6986-83-0)
A long time ago, when people all lived in the kingdoms, they were surrounded by pales. pale. A stake or pointed piece of wood; fence made of stakes used to wall off communities. In current times, social norm dictates that one should stay within the confines of the pale. The pale is…
Genetic code from retroviruses has been found to compose some 8 percent of the human genome, having been copied in during replication and left to be inherited by us and our progeny. But non-retroviral RNA viruses do not use their hosts DNA to replicate-and some do not even enter the host cells nucleus. Nevertheless, new research has turned up surprising evidence that some of these viruses are enmeshed in the genomes of vertebrates-including humans and other mammals ...
1,3-dimethoxy-5-methyl-2-(3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl)benzene 536697-79-7 MSDS report, 1,3-dimethoxy-5-methyl-2-(3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl)benzene MSDS safety technical specifications search, 1,3-dimethoxy-5-methyl-2-(3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl)benzene safety information specifications ect.
Tropical Theileriosis is a parasitic disease of calves with a profound economic impact caused by Theileria annulata, an apicomplexan parasite of the genus Theileria. Transmitted by Hyalomma ticks, T. annulata infects and transforms bovine lymphocytes and macrophages into a cancer-like phenotype characterized by all six hallmarks of cancer. In the current study we investigate the transcriptional landscape of T. annulata-infected lymphocytes to define genes and miRNAs regulated by host cell transformation using next generation sequencing. We also define genes and miRNAs differentially expressed as a result of the attenuation of a T.annulata-infected macrophage cell line used as a vaccine. By comparing the transcriptional landscape of one attenuated and two transformed cell lines we identify four genes that we propose as key factors in transformation and virulence of the T. annulata host cells. We also identify miR- 126-5p as a key regulator of infected cells proliferation, adhesion, survival and ...
J:91358 Brants JR, Ayoubi TA, Chada K, Marchal K, Van de Ven WJ, Petit MM, Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. FEBS Lett. 2004 Jul 2;569(1-3):277-83 ...
(2-methyl-2-adamantyl) prop-2-enoate 249562-06-9 NMR spectrum, (2-methyl-2-adamantyl) prop-2-enoate H-NMR spectral analysis, (2-methyl-2-adamantyl) prop-2-enoate C-NMR spectral analysis ect.
A bis-chalcone has been synthesized by reaction of 3-acetyl-,5-dimethylthiophene and terephthalaldehyde in ethanolic NaOH at room temperature: (2E,2E)-3,3-(1,4-phenylene)bis[1-(2,5-dimethyl-3-thienyl)prop-2-en-1-one] (3) was obtained in high yield. The structure of this compound was established by elemental analysis, IR, 1H NMR, 13C NMR and EI-MS spectral analysis.
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#abcdef 헥스 색상 코드의 색상 스킴, 페인트, 팔레트, 콤비네이션, 그라디언트 및 색상 스페이스 변환.
ေအာ္ ႕႕႕ သက္မဲ့ဆိုေပမယ့္ အလိုက္သိလိုက္တာ။ ငါ့သခင္ ငါ့အရွင္ မရွိေပမယ့္ ငါ့ကိုယ္ငါ ျပဳျပင္ေနႏိုင္တယ္ေပါ့။ ေနမင္းႀကီး ပူစမ္းပါေစ။ ငါခံနိုင္ရည္ရွိပါတယ္။ မိုးေရေတြ ရြာပါေစ မ်ိဳသိပ္ထားမယ္။ ငါအိမ္ေခါင္မလံုတာကို မကဲ႔ရဲ႔နဲ႔။ မင္းတို႔ နွိပ္စက္ခဲ႔လို ...
Theileria annulata , which is part of the Theileria sergenti/Theileria buffeli/Theileria orientalis group, preferentially infects cattle and results in high mortality and morbidity in the Mediterranean, Middle East, and Central Asia. The polypeptide Tams1 is an immunodominant major merozoite...
Bovine cells from cattle infected with Theileria annulata were phenotyped with monoclonal antibodies recognizing bovine leukocyte antigens. Macroschizont-infected, transformed cell lines prepared from peripheral blood mononuclear cells of cattle, infected with sporozoites, were assessed by flow cytometry; parasitized cells in tissues from infected cattle were examined by immunocytochemical techniques. Co-expression of markers for different cell lineages by the cell lines precluded a definite conclusion as to their phenotypic origins. For, while the pattern of leukocyte antigens expressed by these in vivo-derived schizont-infected cells, which included CD11b, was indicative of a myeloid origin, the possibility that they were NK cells could not be excluded. The monoclonal antibody (MAb) IL-A15, which recognizes CD11b, reacted with a high proportion of parasitized cells in sections of tissues from infected cattle at all stages of acute disease. Mononuclear cells infected with parasites at all ...
In this article, we show that c-Jun binds to the HMG-I/Y promoter and induces expression of the HMG-I/Y chromatin binding protein. Decreasing HMG-I/Y proteins using an antisense approach inhibits c-Jun/AP-1-induced transformation, while overexpression of HMG-I/Y confers anchorage-independent cell growth. The colonies in Rat1a cells overexpressing HMG-I/Y were smaller and fewer, suggesting that HMG-I/Y expression only partially recapitulates the c-Jun/AP-1 phenotype. HMG-I/Y is a chromatin remodeling protein with DNA binding domains called AT hooks, which bind to the minor groove of stretches of AT-rich DNA (13-21, 26). Several studies suggest an important role for HMG-I/Y in regulating gene transcription (13-26, 42-44). The HMG-I/Y gene is highly conserved among species; the transcribed regions of the human and mouse HMG-I/Y genes are ∼80% identical at the nucleotide sequence level and ,90% identical when only the protein-coding exons are considered (48). Both mouse and human HMG-I/Y promoters ...
Vicki J. Cowan, age 58, of Sturgis went to be with her Lord and savior Monday afternoon Jan. 11, 2010, at Borgess Medical Center in Kalamazoo. She was born July 22, 1951, in Sturgis, a daughter to the late Elwyn Herald and Naomi (Rumbaugh) Lego. Vicki was a lifelong resident of Sturgis. On Oct. 6, 1968, she married Holton Francis Cowan Jr. in Sturgis. She had been employed as a cashier for several years at Harding’s East in Sturgis. She had also worked as a cashier at Hooks, Speedway and Kroger. She was a certified nurses assistant and had worked in home care services for a few years. Vicki had been attending the Servant Ministry Church in Sturgis. Prior to that she had attended the Christian Fellowship Center and for many years she was an active member of the First Church of God in Sturgis. She enjoyed bowling, puzzles, fishing, flower gardening, cooking and her well-known baking expertise will be missed by many. She was a talented singer and had a true love for her Lord Jesus Christ. She ...
Bacterial and parasitic intracellular pathogens or their secreted products have been shown to induce host cell transcriptional responses, which may benefit the host, favour the microorganism or be unrelated to the infection. In most instances, however, it is not known if the host cell nucleus is proximately required for the development of an intracellular infection. This information can be obtained by the infection of artificially enucleated host cells (cytoplasts). This model, although rather extensively used in studies of viral infection, has only been applied to few bacterial pathogens, which do not include Mycobacterium spp. Here, we investigate the internalization, phagosome biogenesis and survival of M. smegmatis in enucleated type II alveolar epithelial cells. Cytoplasts were infected with M. smegmatis, but the percentage of infection was significantly lower than that of nucleated cells. Scanning electron microscopy indicated that in both cells and cytoplasts, bacteria were internalized ...
Les proteïnes HMG (High Mobility Group) són un grup de proteïnes cromosòmiques no histones que van ser anomenades així degut a la seva mobilitat electroforètica. Aquest conjunt de proteïnes està dividit en tres grans subfamílies: les HMGA, les HMGB i les HMGN. Les proteïnes HMGA poden modificar la conformació espacial del DNA, regulant (positivament o negativament) lexpressió de nombrosos gens i influint en molts processos cel·lulars normals com ara el creixement, proliferació, diferenciació i mort cel·lular, i la reparació del DNA. També estan relacionades amb diferents processos patològics, entre ells lobesitat, la diabetis, larteriosclerosi i el càncer. Sha observat com, en molts tipus de càncers, hi ha una sobre-expressió daquestes proteïnes. Se sap que la interacció HMGA-DNA es dóna a través duns motius dunió al DNA anomenats "AT-hooks", els quals suneixen a regions riques en adenines (A) i timines (T) del DNA. En les proteïnes HMGA es troben tres motius ...
Kalian semua pasti tahu apa nama makhluk hidup di samping ini. Namanya adalah Orca atau Paus Orca. Tapi, tahukah kalian, kalau sebenarnya Orca merupakan sejenis lumba-lumba (delphinidae) terbesar di dunia. Mengapa bisa dibilang terbesar ? Soalnya, panjang tubuh dari Orca ini bisa mencapai 7 meter. Terus...kenapa orang-orang menyebut Orca dengan nama Paus Orca,hmmmm....mungkin karena ukuran tubuhnya yang besar sehingga lebih mirip sama paus daripada lumba-lumba.. Orca memiliki ciri-ciri khusus yang sangat menyolok yaitu warna belangnya yang hitam dan putih. Selain itu, Orca juga termasuk kelompok hewan yang cerdas. Orca hidup secara berkelompok dan dipimpin oleh seekor Orca betina. Orca berkomunikasi dengan menggunakan suara ultrasonik. Suara ini tidak dapat didengar oleh manusia karena getaran suara ini sangat tinggi.. Orca termasuk hewan predator atau pemangsa. Mereka memakan ikan, burung, singa dan anjing laut, bahkan hiu sekalipun. Mungkin karena itu juga, Orca memiliki julukan berupa Paus ...
Graham, SP, Brown, DJ, Vatansever, Z, Waddington, D, Taylor, LH, Nichani, AK, Campbell, JD, Adamson, RE, Glass, EJ and Spooner, RL (2001) Proinflammatory cytokine expression by Theileria annulata infected cell lines correlates with the pathology they cause in vivo. ...
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High-mobility group protein HMG-I/HMG-Y is a protein that in humans is encoded by the HMGA1 gene. This gene encodes a non-histone chromatin protein involved in many cellular processes, including regulation of inducible gene transcription, DNA replication, heterochromatin organization, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. HMGA1 proteins are quite small (~10-12 kDa) and basic molecules, and consist of three AT-hooks with the RGRP (Arg-Gly-Arg-Pro) core motif, a novel cross-linking domain located between the second and third AT-hook, and a C-terminal acidic tail characteristic for the HMG family comprising HMGA, HMGB and HMGN proteins. HMGA1-GFP fusion proteins are highly dynamic in vivo (determined using FRAP analysis), but in contrast also show nanomolar affinity to AT-rich DNA in vitro (determined biochemically), which might be explained due to the extensive post-transcriptional modifications in vivo. HMGA1 preferentially binds to the ...
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Phosphane nehmen eine herausragende Stellung als Liganden in der homogen Katalyse ein. In der Arbeitsgruppe Thiel wurde kürzlich ein neuartiges Verfahren zur Synthese von Triarylphosphanen entwickelt. Im ersten Teil der Arbeit stand daher die Weiterentwicklung dieser fluoridkatalysierten Phosphor-Aryl-Kupplung im Mittelpunkt. Ein wichtiges Ziel hierbei war die Übertragung der Reaktionen in einen größeren Maßstab. In einem Ansatz konnte 1 kg an (4-[3-(N,N-Dimethylamino)prop-2-en-1-onyl]phen-yl)diphenylphosphan in einer Pilotanlage synthetisiert werden. Diese Verbindung diente als „Plattformchemikalie
"The extended AT-hook is a novel RNA binding motif". RNA Biology. 12 (8): 864-76. doi:10.1080/15476286.2015.1060394. PMC 4615771 ...
The Ni-hook contains the motif His-Cys-X-X-Pro-Cys-Gly-X-Tyr; it provides most of the interactions critical for metal binding ... This has a hexameric (6-copy) structure built from right-handed 4-helix bundles, each containing N-terminal hooks that chelate ...
In Turkmenistan, hook and tulip motifs could be worked in buttonhole stitch. In Afghanistan, men's shirts could be embroidered ... Embroidered motifs often carry symbolic meaning. A widespread symbol across the Islamic world (and also often found on Islamic ... Tambour work, a rapid form of embroidery using a fine ari hook instead of a needle, was one of the techniques used around ... Carnation and pomegranate motifs symbolised fertility. The technique was also used in Afghanistan and Uzbekistan for horse ...
These guls often contain star or (hooked) dragon motifs as found on 15th century Konya carpets. The presence of the hooked ... ISBN 1-84472-099-3. Howe, R. John (2 October 2010). "The "Memling" Gul Motif, The Lecture". R. John Howe. Retrieved 28 January ... ISBN 0-7126-2501-1. "Carpet Motifs: A Beginner's Guide". Arastan. 9 May 2012. Retrieved 28 January 2016. Mace, Ruth; Holden, ... Islamic geometric patterns Kilim motifs Flag of Turkmenistan "Rug Gallery. Carpet Turkey (Kurdish) 18th century". MathForum. ...
"OMIM Entry - * 615790 - AT-HOOK DNA-BINDING MOTIF-CONTAINING PROTEIN 1; AHDC1". www.omim.org. Retrieved 2015-10-18. "Xia-Gibbs ... "De novo truncating variants in the AHDC1 gene encoding the AT-hook DNA-binding motif-containing protein 1 are associated with ...
"OMIM Entry - * 615790 - AT-HOOK DNA-BINDING MOTIF-CONTAINING PROTEIN 1; AHDC1". www.omim.org. Retrieved 2015-10-18. Xia, Fan; ... AT hook, DNA binding motif, containing 1) on chromosome 1p36 . Note: 32 Cases worldwide to this date (January 11, 2017) have ... "De novo truncating variants in the AHDC1 gene encoding the AT-hook DNA-binding motif-containing protein 1 are associated with ...
The folding triangular gnomon is supported by a decorative open-work motif. The lid of the box is secured by a hook fastener. ...
Stith-Thompson motif index D1313.1.1. "Magic ball of thread indicates road" krók-stjaki a, m. a boat-hook (Cleasby-Vigfusson ... The variants give different names of protagonists, featured motifs, etc. A retold version of it by Ruth Manning-Sanders under ... and though she would threaten to make a meal of him in the pot and seize him with a boat-hook, he should bribe her with the ...
... retained by hook. The blade may have the Seal of Solomon motif pressed into the blade. Other popular imprints include the ...
... is an AT-hook transcription factor which contains AT-hook binding motif. The protein is expressed as different isoforms. ... Mar 2001). "Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA". Nature. 410 (6826): 383-7. doi: ...
Repetition is a part and parcel of symmetry-and of establishing motifs and hooks. You find a melodic or rhythmic figure that ...
Although forcing captives to walk the plank is a motif of pirates in popular culture in the 19th through 21st centuries, few ... where Captain Hook's pirates helped define the archetype. The term has been used in modern times to describe the resignation of ... Treasure Island also popularized other now-common pirate motifs such as parrots, peglegs, and buried treasure.) The concept ... The practice has been used in several modern films such as Hook, Down Periscope, and Pirates of the Caribbean: The Curse of the ...
Religious Motifs: Buddha head, Stupa, a temple shaped like a pyramid, and/or ancestors riding on mythological animals. Source: ... Plant Designs: tree, flower, vine, seed, fruit, leaf, and geometrical shapes like zigzag line, diamond, hook, and/or star. ... Of the exceptional wealth of ornamentation, four groups of motifs have been distinguished: Mythical Animals under the Water: ...
Parallels were shown between the "opposed animal" and "latch-hook" motifs from woven pile rugs and the Lorestān bronzes. These ... and are probably part of a unified socio-cultural motif. A related motif in ancient art is known as the Mistress of Animals. It ... The motif called the Tree of Life, where two confronted animals graze on a shrub or tree, is also very ancient. The reverse ... A traditional Chinese motif, the fight between phoenix and dragon, is seen in an Anatolian carpet now displayed at the Pergamon ...
The motifs are then joined using chains and picots. When all the motifs have been joined together to form one piece of lace, ... Irish Crochet Lace is made with a very fine steel crochet hook and fine crochet cotton or linen thread. It begins with an ... Each motif is then crocheted separately, using cotton cord for volume and shaping. The finished motifs are then basted (sewn ... This type of lace is characterized by separately crocheted motifs, which were later assembled into a mesh background. Other ...
The design motifs on early American hooked rugs varied, consisting predominantly of geometric patterns, floral designs, ... No matter what the motif, hooked rugs displayed a great sense of individual expression. Neff, Ivan C. and Carol V. Maggs. ... The history of rugs in America is extensive; however, today hooked rugs and Navajo rugs are synonymous with American rug design ... Settlers who were working with limited resources developed hooked rugs in the 17th century. The rugs continued to be popular ...
The xicalcoliuhqui motif is featured on either side of the staircase on The Pyramid of the Niches at the Veracruz site of El ... It is composed of three or more steps connected to a hook or spiral, reminiscent of a "greek-key" meander. Pre-Columbian ... The motif is associated with many ideas, and is variously thought to depict water, waves, clouds, lightning, a serpent or ... The motif has been in continual use from the pre-Columbian era to the present. The word xicalcoliuhqui (Nahuatl pronunciation ...
DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains". Cell. 82 (1): 57-65. doi:10.1016/ ... High-mobility group AT-hook 2, also known as HMGA2, is a protein that, in humans, is encoded by the HMGA2 gene. This gene ... The transport of HMGA2 to the nucleus is mediated by an interaction between its second AT-hook and importin-α2. HMGA GRCh38: ... "Entrez Gene: HMGA2 high mobility group AT-hook 2". Fedele M, Battista S, Kenyon L, Baldassarre G, Fidanza V, Klein-Szanto AJ, ...
"Victoria Line tile motifs - Vauxhall". Go London. Retrieved 11 August 2014. The English pleasures of Vauxhall John Barrell, 25 ... John Hebden, principal cellist and bassoonist, 1745 James Hook, organist and composer at Vauxhall Gardens, 1773-1820. Louis ... Vauxhall Gardens is depicted in a tile motif at Vauxhall tube station, done in about 1971 by George Smith. Eminent 18th-century ...
Common motifs in Persian carpets Boteh motif Bidjar rug with Herati pattern Pictorial carpet with Tree of life, birds, plants, ... In Tabriz the knife is combined with a hook to tie the knots, which speeds up work. A small steel comb is sometimes used to ... flowers and vase motifs Safavid period carpet (detail): Shah Abbasi motif Karaja carpet with Bid Majnūn, or "weeping willow" ... Shah Abbasi motifs are frequently seen in Kashan, Isfahan, Mashhad and Nain rugs. The Bid Majnūn, or Weeping Willow design is ...
... : very rare "Bird of Prey Flute." Woodlands-style with carved "Bird of Prey" and "Rattlesnake" motifs - vintage ... Starting from oldest to youngest, Sondra Kay LittleJohn, Kimberly Evelyn LittleJohn, Bow Hook Synder LittleJohn, Joshua ...
... this motif takes on a highly ordered structure and forms the enzyme's active site. The nickel binding hook is composed of the ... The active site, like the rest of the nickel binding hook, is disordered when nickel isn't bound. Ni-SOD has a unique set of ... In order to expose the nickel-binding hook, a leader sequence must be enzymatically cleaved off the N-terminus. Wuerges J, Lee ... This region has a curved and disordered shape in the absence of nickel, which gives it its nickname, "the nickel binging hook ...
... resulting in the loss of three C-terminal AT-hook motifs. SRCAP encodes a SNF2-related chromatin-remodeling ATPase that is a ... and three C-terminal AT-hook DNA-binding motifs). The CBP interaction domain of SRCAP is located centrally. Thus, the mechanism ...
IAP-binding motifs (IBMs) are constructed from amino-terminal tetrapeptides. The binding sites of the IBMs are between the last ... In caspase-3 the 'hook' and 'sinker' attach. Both the BIR2 and BIR3 have a groove that is predominately negatively charged. ... This negative charge in BIR3 allows the attachment of the IAP-binding motif, causing enzymatic activity to be inhibited. When ...
... containing Ankyrin repeats hooked to a zinc finger motif". Biochemical and Biophysical Research Communications. 257 (1): 206-13 ... and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be ...
The ORC4 protein is known to bind the AT-rich portion of the origin of replication in S. pombe using AT hook motifs. The ...
SAP97's protein structure consists of an alternatively-spliced n-terminal domain, three PDZ domains, an SH3 domain, hook domain ... Bassand P, Bernard A, Rafiki A, Gayet D, Khrestchatisky M (Jun 1999). "Differential interaction of the tSXV motifs of the NR1 ... 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif". ...
Another tool which is allowed and must be used is a round hook, which is put into the blow hole of the whale in order to drag ... In Faroese literature and art, grindadráp is an important motif. The grindadráp paintings by Sámal Joensen-Mikines rank ... The pilot whales that are not beached were earlier often stabbed in the blubber with a sharp hook, called a sóknarongul, (a ... The dull blowhole hook, adopted in response to concerns over cruelty, had the additional effect of further increasing the ...
Short name: AT_hook_DNA-bd_motif Description. AT hooks are DNA-binding motifs with a preference for A/T rich regions. These ... DNA-binding properties of the recombinant high-mobility-group-like AT-hook-containing region from human BRG1 protein.. Biol. ... Novel members of a family of AT hook-containing DNA-binding proteins from rice are identified through their in vitro ... motifs are found in a variety of proteins, including the high mobility group (HMG) proteins [PMID: 11406267], in DNA-binding ...
Synonyms: AT-hook DNA-binding motif-containing protein 1, DJ159A19.3, RP1-159A19.1 ...
Ice-Logo analysis of the Type-I AT-hook motifs (a) and Type-II AT-hook motifs (b) in land-plant AH ... Type of AHL proteins and their AT-hook motifs in land plants. ... Ice-Logo analysis of the Type-I AT-hook motifs (a) and Type-II ... Fig3: Type of AHL proteins and their AT-hook motifs in land plants. Ice-Logo analysis of the Type-I AT-hook motifs (a) and Type ... some of the AHLs contain only one copy of the Type-II AT-hook motifs and the rest contain both types of AT-hook motifs.Figure 3 ...
Garment hook with feline motif Artist: Date: 19th century. Accession Number: 02.18.710 Date: 19th century Medium: Jade (jadeite ... Garment hook Artist: Date: 19th century. Accession Number: 02.18.507 Date: 19th century Medium: Jade (jadeite) Accession: 02.18 ...
HCA RNA Cell Line for AT-hook DNA-binding motif-containing protein 1. ... This gene encodes a protein containing two AT-hooks, which likely function in DNA binding. Mutations in this gene were found in ...
Dont go from store to store to find the best prices on fendi ff karligraphy motif signet ring - f0th0-palladium, weve got ... Featuring a french hook closure, an e … Farfetch:Linkshare:Affiliate:CPA:US:US ... Fendi FF Karligraphy motif signet ring - F0cfk-Soft Gold. Fendi constantly reinvents itself with abstract, graphic motifs for ... Ff Karligraphy Motif Signet Ring - Metallic - Fendi Rings. Fendi Ff Karligraphy Motif Signet Ring - Fendi constantly reinvents ...
AT-Hook DNA Binding Motif Containing 1, including: function, proteins, disorders, pathways, orthologs, and expression. ... AT-hook DNA-binding motif-containing protein 1. Protein Accession:. Q5TGY3. Secondary Accessions: *Q5TGY4 ... AHDC1 (AT-Hook DNA Binding Motif Containing 1) is a Protein Coding gene. Diseases associated with AHDC1 include Xia-Gibbs ... This gene encodes a protein containing two AT-hooks, which likely function in DNA binding. Mutations in this gene were found in ...
Weave motif print. Turtleneck. Long sleeves. Back zipper with hook. 100% viscose. 65 cm height. ... The striking Weave motif dominates this long-sleeved organzine turtleneck top. The back, decorated with the logo, has a zipper ...
Varied: Art motifs imitate music. Published on Mar 20th, 2003. 0 comments Artist Farida Hughes name-checks composers Edward ...
A polymorphism in the AT-hook motif of the transcriptional regulator AKNA is a risk factor for cervical cancer.. Perales G1, ... at the DNA binding AT-hook motif. Genotype frequencies in 97 allele pairs were: R/R = 0.597, R/Q = 0.278, Q/Q = 0.123. Q/Q ...
Journal Club: Understanding how a plant makes a hook could someday improve crops ... showed that soluble fragments spanning the SNARE motif are generally unstructured (17-21), although the syntaxin-1 SNARE motif ... Soluble Synaptobrevin SNARE Motif Binds to DPC Micelles but not to Liposomes.. Given the contrast of our conclusions with those ... These motifs have a high tendency to form amphipathic coiled-coils that assemble into four-helix bundles, and often precede ...
"The extended AT-hook is a novel RNA binding motif". RNA Biology. 12 (8): 864-76. doi:10.1080/15476286.2015.1060394. PMC 4615771 ...
Polished sterling silver with carved chain motif. Black woven leather with sterling silver bead. Handcrafted in Thailand. Hook- ... Polished sterling silver with carved chain motif. Black woven leather with sterling silver bead. Handcrafted in Thailand. Hook- ... Signature sterling silver with carved chain-motif beads. 6mm tiger iron, riverstone and kokka wood beads. Two beaded rows with ... Signature sterling silver with carved chain-motif beads. 6mm tiger iron, riverstone and kokka wood beads. Two beaded rows with ...
ankyrin repeat hooked to zinc finger motif. ankyrin repeats hooked to a zinc finger motif. rank-5. ... Molecular cloning of a novel 130-kDa cytoplasmic protein, Ankhzn, containing Ankyrin repeats hooked to a zinc finger motif. Ito ... containing Ankyrin repeats hooked to a zinc finger motif. ... ANK; ANK repeat [structural motif]. RNA. * NR_047571.2 RNA ... ANK; ANK repeat [structural motif]. pfam12796. Location:231 → 339. Ank_2; Ankyrin repeats (3 copies). ...
AT hook, DNA-binding motif. Pfam Annotation. Protein. Pfam ID. E.value. Name. Description. ...
AT hook, DNA-binding motif. XP_003938328. SMART. SM00413. IPR000418. 272. 359. 2.00e-51. Ets domain. ...
IPR017956. AT_hook_DNA-bd_motif. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR014012. HSA_dom. IPR027417. P-loop_ ... IPR017956. AT_hook_DNA-bd_motif. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR014012. HSA_dom. IPR027417. P-loop_ ... SM00384. AT_hook. 3 hits. SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00573. HSA. 1 hit. ... SM00384. AT_hook. 3 hits. SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00573. HSA. 1 hit. ...
A hook. A repeating motif. The garden, this time. The garden, and the open jaws of the dead. Ammar tried to step away from the ...
IPR017956 AT_hook_DNA-bd_motif. IPR000116 HMGA. IPR031079 HMGA1_mammal. IPR000637 HMGI/Y_DNA-bd_CS. ... IPR017956 AT_hook_DNA-bd_motif. IPR000116 HMGA. IPR031079 HMGA1_mammal. IPR000637 HMGI/Y_DNA-bd_CS. ... "Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif.". Eckner ... A.T hook 3Add BLAST. 12. ,p>The ,a href="http://www.geneontology.org/">Gene Ontology (GO),/a> project provides a set of ...
IPR017956 AT hook, DNA-binding motif. IPR000116 High mobility group protein HMGA ...
3 column, 2 row hook and eye back closure * Luxe stretch microfiber with Guipure lace detail ... Gorgeously designed with floral motif * Embroidery on front stretch straps with back adjusters ...
DR Gene3D; 1.20.920.10; -; 1. DR Gene3D; 3.30.40.10; -; 1. DR InterPro; IPR017956; AT_hook_DNA-bd_motif. DR InterPro; IPR006560 ... ECO:0000255,PROSITE- FT ProRule:PRU00370}. FT DNA_BIND 885 897 A.T hook 1. FT DNA_BIND 1345 1357 A.T hook 2. FT DNA_BIND 1843 ... DR Pfam; PF01426; BAH; 1. DR Pfam; PF00439; Bromodomain; 1. DR Pfam; PF00856; SET; 1. DR SMART; SM00384; AT_hook; 4. DR SMART; ... 1855 A.T hook 3. FT ZN_FING 2574 2620 PHD-type. FT REGION 2059 2278 Catalytic domain. {ECO:0000250}. FT COMPBIAS 1378 1422 Pro- ...
DR InterPro; IPR017956; AT_hook_DNA-bd_motif. DR InterPro; IPR013721; STAG. DR Pfam; PF08514; STAG; 1. DR PRINTS; PR00929; ... DR SMART; SM00384; AT_hook; 6. PE 4: Predicted; KW Complete proteome {ECO:0000313,Proteomes:UP000018888}; KW Reference proteome ...
Euro style hook makes changing the roll quick and easy.\n\n\t*Made Of The Finest Solid Brass Materials ... The contemporary motif from this elegant collection has timeless appeal. European Style Toilet Tissue Holder is constructed of ...
14-karat rose gold-filled rope-motif wire. Choose up to 10 wire letters. Hook-and-eye clasp. Approx. 6"L. Made in USA. Please ... 14-karat rose gold-filled rope-motif wire. Choose up to five wire letters. Hook-and-eye clasp. Approx. 6"L. Made in USA. Please ... Hook-and-eye clasp. Made in USA. Please Note: Personalized items may not be ordered blank. Please order carefully. Orders for ... Safety-hook closure. Approx. 6"L. Made in USA. Please Note: Personalized items may not be ordered blank. Please order carefully ...
  • 7 and 16 ), but detailed structural information on the isolated SNARE motifs attached to their adjacent TM regions is more limited. (pnas.org)
  • In 1997 structural studies using NMR determined that a DNA-bound AT-hook adopted a crescent or hook shape around the minor groove of a target DNA strand (pictured at right). (wikipedia.org)
  • MARs consist of AT-rich sequences extending over at least a few hundred base pairs and containing various AT-rich motifs as well as structural motifs such as base-unpairing regions and intrinsically curved portions ( Boulikas, 1995 ). (plantcell.org)
  • This pewter speaking trumpet was presented to Andrew J. Walsh during the late 19th century by fellow members of the Hibernia Hook and Ladder Company. (si.edu)
  • NMR studies in dodecylphosphocholine (DPC) micelles suggested that the N-terminal half of the SNARE motif from the neuronal SNARE synaptobrevin binds to membranes, which appeared to contradict previous biophysical studies of synaptobrevin in liposomes. (pnas.org)
  • On the other hand, NMR studies in dodecylphosphocholine (DPC) micelles indicated that much of the N-terminal half of the synaptobrevin SNARE motif (residues 36-54) also binds to the micelles, forming an α-helix ( 26 ). (pnas.org)
  • The AT-hook binds to the minor groove of adenine-thymine (AT) rich DNA, hence the AT in the name. (wikipedia.org)
  • Inspired by the beautiful damask drapes in my mom's home, I designed this lacy afghan with join-as-you-go motifs coupled with a solid stitch border, as that is really my style--a little something lacy with a solid edge to it. (ravelry.com)
  • Coordinated regulation of apical hook development by gibberellins and ethylene in etiolated Arabidopsis seedlings. (nih.gov)
  • Dark-grown Arabidopsis seedlings develop an apical hook when germinating in soil, which protects the cotyledons and apical meristematic tissues when protruding through the soil. (nih.gov)
  • Instantly add hanging space and plenty of style to your home's bathroom or powder room with this Uptown Satin Nickel Robe Hook, available exclusively at Bellacor Lighting. (bellacor.com)
  • Fendi constantly reinvents itself with abstract, graphic motifs for logos and the signature FF monogram patterns, sprawled across contemporary offerings each season, as showcased with this silver-tone brass FF Karligraphy motif signet ring. (realsimple.com)
  • Either way, the lacy holes and motif-as-you-go construction makes this a project you can crochet in an afternoon. (makezine.com)
  • With the 3.75mm hook, 2 sc in each space around, 5 ch in each corner space, and 3 sc in the spaces on either side of the Connection Row. (makezine.com)
  • Previous studies have shown that ethylene and gibberellins (GAs) coordinately regulate the hook development, although the underlying molecular mechanism is largely unknown. (nih.gov)
  • Treatment with naphthylphthalamic acid, a polar auxin transport inhibitor, repressed the constitutively exaggerated hook curvature of EIN3ox line and della mutant, supporting that auxin functions downstream of the ethylene and GA pathways in hook development. (nih.gov)
  • The back, decorated with the logo, has a zipper and hook closure. (prada.com)
  • Center back closure of covered hook & eye on waistband and 2 snaps. (unt.edu)
  • Gold circle buckle with two hooks and three pairs of grommets for closure. (unt.edu)
  • Collarless with single hook & eye closure. (unt.edu)
  • Back cut-out with hook and eye closure. (shopstyle.com)
  • Fits true to size, order your normal size Designed for a contemporary fit V-neck, adjustable spaghetti straps Sequin bodice, lace skirt, sheer scalloped hem Sheer mesh back Concealed back zip with hook-and-eye closure, nude lining Approx. (shopstyle.com)
  • A single-nucleotide polymorphism at codon 1119 of AKNA, yields a biologically relevant amino acid change (R1119Q) at the DNA binding AT-hook motif. (cdc.gov)
  • BPdc (Back Post double crochet): Yarn over, insert hook from back to front to back around post of next st, yarn over and draw up a loop, [yarn over and draw through 2 loops on hook] twice. (favecrafts.com)
  • just use a corresponding hook to match the yarn. (ravelry.com)
  • Genetic study revealed that GA-enhanced hook development was dependent on HOOKLESS 1 (HLS1), a central regulator mediating the input of the multiple signaling pathways during apical hook development. (nih.gov)
  • The star symbol denotes the core sequence of the AT-hook motif. (nih.gov)
  • This motif consists of a conserved, palindromic, core sequence of proline-arginine-glycine-arginine-proline, although some AT-hooks contain only a single proline in the core sequence. (wikipedia.org)
  • AT-hooks also include a variable number of positively charged lysine and arginine residues on either side of the core sequence. (wikipedia.org)
  • 1' self waistband, with hook-and-bar on waistband above zipper. (unt.edu)
  • This stylish utility hook is a beautiful and functional accent for any roo. (bellacor.com)
  • A line-up of classical busts behind reception give a nod to the grands hommes 'great men' (and women) buried in the Pantheon opposite and highly stylized period décor throughout the hotel - lots of Toile de Jouy fabrics with neo-classical motifs and Empire canapes - mirrors the monument's elegant, late-18th-century neoclassical architecture. (telegraph.co.uk)
  • Dapper Bordeaux-and-cream striped wallpaper, richly coloured carpets, beautiful Pierre Frey fabrics printed with neoclassical motifs and the odd original beamed ceiling contribute to the enchanting old-world vibe - the antique black-marble desk in our room was positively regal. (telegraph.co.uk)
  • His on-trend designs are inspired by vintage fabrics and motifs, and offer a fresh, up-to-date accent for any home. (lampsplus.com)
  • We hypothesize that the underlying mechanism for mutagenesis induced by fragile motifs involves the formation of long single-stranded regions in the broken chromosome, invasion of the undamaged sister chromatid for repair, and faulty DNA synthesis employing Polζ. (prolekare.cz)
  • The street-length neck has a deep V-neckline formed by the overlap of front opening, which has snap and hook & eyes closures from waist. (unt.edu)
  • They are absolutely lovely and due to the diverse locations and motifs you feature, strolling through the gallery is like going on a mini vacation. (painterskeys.com)
  • NMR analyses of synaptobrevin reconstituted into nanodiscs and into liposomes now show that most of its SNARE motif, except for the basic C terminus, is highly flexible, exhibiting cross-peak patterns and transverse relaxation rates that are very similar to those observed in solution. (pnas.org)
  • If your edging is too loose or too tight, try a different hook size. (makezine.com)
  • Taken together, our results identify EIN3/EIL1 as a new class of DELLA-associated transcription factors and demonstrate that GA promotes apical hook formation in cooperation with ethylene partly by inducing the expression of HLS1 via derepression of EIN3/EIL1 functions. (nih.gov)
  • Over-calf-height square-toed boots lace up front, with 3 rows of eyelets at bottom and 15 hooks above. (unt.edu)
  • if using lace weight the motifs will be finer and smaller and with dk the motifs will be thicker and bigger. (ravelry.com)
  • For MAR binding, the AT hook at the C terminus was essential, and an internal portion containing the Zn finger-like motif was additionally required in vivo. (plantcell.org)
  • Robe Hook is constructed of the finest solid brass materials to provide a sturdy hook for your robes and towels. (bellacor.com)
  • Yellow beads recycled from plastic bottles and vinyl discs are diligently threaded by hand for a necklace that fastens with a brass hook. (novica.com)
  • Diamond motif of stitching and small vinyl diamonds at yoke and pockets. (unt.edu)
  • I am holed up in a remote valley in southern France to paint - no shortage of inspiration here in the Cevennes and plenty of 'hook hours. (painterskeys.com)
  • If the directions instruct you to stitch "into" a specific chain, then put your hook under the two top V strands of the chain stitch. (makezine.com)
  • The Design House 539197 Millbridge Double Robe Hook adds an elegant acce. (bellacor.com)
  • The Tavern Suite Encompasses the Decorative Details of a Nostalgic Aura, Yet Adds the Necessary Finesse to Create a Modern-Day Motif. (bellacor.com)
  • Featuring a unique hand-hooked construction, each design in the collection showcases a textured loop pile that adds dimension to the motifs. (authenteak.com)
  • Center front opening with hook-and-eye at top, single gold-tone circular button visible at throat, and 6 hidden clear plastic buttons. (unt.edu)
  • AT hooks are DNA-binding motifs with a preference for A/T rich regions. (ebi.ac.uk)
  • These motifs have a high tendency to form amphipathic coiled-coils that assemble into four-helix bundles, and often precede transmembrane regions. (pnas.org)