Asymmetric cell division. Medical search

Unequal cell division that results in daughter cells of different sizes.

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

Compounds, either natural or synthetic, which block development of the growing insect.

Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains.

A microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.

Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.

A species of nematode that is widely used in biological, biochemical, and genetic studies.

Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.

The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.

Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.

A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.

Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM.

Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.

A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.

Closable openings in the epidermis of plants on the underside of leaves. They allow the exchange of gases between the internal tissues of the plant and the outside atmosphere.

The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.

A broad category of nuclear proteins that are components of or participate in the formation of the NUCLEAR MATRIX.

The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).

Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

A species of fruit fly much used in genetics because of the large size of its chromosomes.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.

The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.

Protein factors that inhibit the dissociation of GDP from GTP-BINDING PROTEINS.

ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.

Proteins found in any species of helminth.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

The functional hereditary units of HELMINTHS.

A species of gram-negative, aerobic bacteria that consist of slender vibroid cells.

A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.

Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.

The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)

Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.

Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.

A family of seven-pass transmembrane cell-surface proteins that combines with LOW DENSITY LIPROTEIN RECEPTOR-RELATED PROTEIN-5 or LOW DENSITY LIPROTEIN RECEPTOR-RELATED PROTEIN-5 to form receptors for WNT PROTEINS. Frizzled receptors often couple with HETEROTRIMERIC G PROTEINS and regulate the WNT SIGNALING PATHWAY.

The fertilized OVUM resulting from the fusion of a male and a female gamete.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.

Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.

Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.

Transport proteins that carry specific substances in the blood or across cell membranes.

The GTPase-containing subunits of heterotrimeric GTP-binding proteins. When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems.

Proteins found in any species of insect.

Proteins found in any species of bacterium.

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

A family of multisubunit cytoskeletal motor proteins that use the energy of ATP hydrolysis to power a variety of cellular functions. Dyneins fall into two major classes based upon structural and functional criteria.

Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

A type of CELL NUCLEUS division, occurring during maturation of the GERM CELLS. Two successive cell nucleus divisions following a single chromosome duplication (S PHASE) result in daughter cells with half the number of CHROMOSOMES as the parent cells.

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

Proteins which are involved in the phenomenon of light emission in living systems. Included are the "enzymatic" and "non-enzymatic" types of system with or without the presence of oxygen or co-factors.

Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

Heat and stain resistant, metabolically inactive bodies formed within the vegetative cells of bacteria of the genera Bacillus and Clostridium.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.

Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.

Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.

Morphological and physiological development of EMBRYOS.

Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.

A species of gram-positive bacteria that is a common soil and water saprophyte.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.

The process by which the CYTOPLASM of a cell is divided.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.

Elements of limited time intervals, contributing to particular results or situations.

Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.

A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.

The process by which the CELL NUCLEUS is divided.

The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.

Acetic acid derivatives of the heterocyclic compound indole. (Merck Index, 11th ed)

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

The process by which a DNA molecule is duplicated.

A group of plant cells that are capable of dividing infinitely and whose main function is the production of new growth at the growing tip of a root or stem. (From Concise Dictionary of Biology, 1990)

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

Proteins obtained from ESCHERICHIA COLI.

Immortalized, pre-malignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA. (1/72)

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JMY is required for asymmetric division and cytokinesis in mouse oocytes. (2/72)

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Isolation of live label-retaining cells and cells undergoing asymmetric cell division via nonrandom chromosomal cosegregation from human cancers. (3/72)

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Chasing the immortal strand: evidence for nature's way of protecting the breast genome. (4/72)

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The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization. (5/72)

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Fly meets yeast: checking the correct orientation of cell division. (6/72)

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Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts. (7/72)

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Molecular profiling of stomatal meristemoids reveals new component of asymmetric cell division and commonalities among stem cell populations in Arabidopsis. (8/72)

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The term asymmetric cell division usually refers to such intrinsic asymmetric divisions. In order for asymmetric division to ... The single cell is now set up to undergo an asymmetric cell division, however the orientation in which the division occurs is ... An asymmetric cell division produces two daughter cells with different cellular fates. This is in contrast to symmetric cell ... In normal stem and progenitor cells, asymmetric cell division balances proliferation and self-renewal with cell-cycle exit and ...

https://en.wikipedia.org/wiki/Asymmetric_cell_division

Knoblich, Juergen A. (February 2008). "Mechanisms of Asymmetric Stem Cell Division". Cell. 132 (4): 583-597. doi:10.1016/j.cell ... For example, stem cells can divide asymmetrically, which means the two resultant daughter cells may have different fates ( ... In cell biology, single-cell variability occurs when individual cells in an otherwise similar population differ in shape, size ... Similar to variation in the metabolome, the proteins present in a cell and their abundances can vary from cell to cell in an ...

https://en.wikipedia.org/wiki/Single-cell_variability

Biology portal Epithelial polarity Cell migration Embryogenesis Embryonic development Asymmetric cell division 3D cell culture ... and migrating cells. Furthermore, cell polarity is important during many types of asymmetric cell division to set up functional ... asymmetric cell division, in which two daughter cells receive different amounts of cellular material (e.g. mRNA, proteins), 2) ... "Asymmetric cell division and axis formation in the embryo". www.wormbook.org. Retrieved 2018-04-06. Munro, Edwin; Nance, Jeremy ...

https://en.wikipedia.org/wiki/Cell_polarity

This asymmetric cell division usually occurs early in embryogenesis. Positive feedback can create asymmetry from homogeneity. ... Semin Cell Dev Biol 2009, 20:972-977. Segalen, M.; Bellaïche, Y. (2009). "Cell division orientation and planar cell polarity ... two of which are by the combination of transcription factors the cells have and by the cell-cell interaction. Cells' fate ... If a cell is in a determined state, the cell's fate cannot be reversed or transformed. In general, this means that a cell ...

https://en.wikipedia.org/wiki/Cell_fate_determination

... as well as asymmetric cell division. His laboratory employs notably the model organism C. elegans and human cell lines in their ... His research focuses on centriole biology and asymmetric cell division. He is currently professor at École Polytechnique ... Germany as a postdoctoral research fellow with Anthony Hyman to work on cell biology, cell division, and early embryonic ... "Functional genomic analysis of cell division in C. Elegans using RNAi of genes on chromosome III". Nature. 408 (6810): 331-336 ...

https://en.wikipedia.org/wiki/Pierre_Gönczy

"Polarized Myosin Produces Unequal-Size Daughters During Asymmetric Cell Division". Science. 330 (6004): 677-680. Bibcode: ... During the division of the fertilized oocyte, cells aggregate and the compactness between cells increases with the help of ... It focuses on how physical forces and changes in the mechanical properties of cells and tissues contribute to development, cell ... Cell. 123 (5): 917-929. doi:10.1016/j.cell.2005.08.040. ISSN 0092-8674. PMID 16325584. S2CID 13242763. Buganza Tepole, A; Ploch ...

https://en.wikipedia.org/wiki/Mechanobiology

"Virus-induced cell gigantism and asymmetric cell division in archaea". Proceedings of the National Academy of Sciences of the ... induce cell gigantism by blocking the expression of the cell division genes and arresting the cell cycle in the S phase. The ... Cell. 185 (8): 1297-1307.e11. doi:10.1016/j.cell.2022.02.019. PMID 35325592. Liu, J; Cvirkaite-Krupovic, V; Baquero, DP; Yang, ... Entry into the host cell is achieved by attachment of the viral proteins to host receptors. DNA-templated transcription is the ...

https://en.wikipedia.org/wiki/Bicaudaviridae

"Virus-induced cell gigantism and asymmetric cell division in archaea". Proceedings of the National Academy of Sciences of the ... islandicus cells by blocking the expression of the cell division genes and arresting the cell cycle in the S phase. The ... diameter of infected cells increases up to 20 times, resulting in 8,000-fold increase in volume compared to noninfected cells. ...

https://en.wikipedia.org/wiki/Sulfolobus_tengchongensis_spindle-shaped_virus

Li, S; Brazhnik, P; Sobral, B; Tyson, JJ (2009). "Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter ... These efforts fall far short of an exact, fully predictive computer model of a cell's entire behavior. Limitations in the ... In silico computer-based modeling technologies have also been applied in: Whole cell analysis of prokaryotic and eukaryotic ... In Silico Cell For TB Drug Discovery. ScienceDaily. Retrieved February 12, 2010. ...

https://en.wikipedia.org/wiki/In_silico

In symmetric cell division, both daughter cells are also stem cells. In asymmetric division, a stem cell produces one stem cell ... They undergo symmetric or asymmetric cell division into two daughter cells. ... Once activated, the Type B cells develop into Type C cells, active proliferating intermediate cells, which then divide into ... Neural stem cells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that ...

https://en.wikipedia.org/wiki/Neural_stem_cell

... the first cell division is highly asymmetric. C. elegans embryogenesis is among the best understood examples of asymmetric cell ... A second cell division produces the ABp and ABa cells from the AB cell, and the EMS and P2 cells from the P1 cell. This ... The resulting daughter cells of the first cell division are called the AB cell (containing PAR-6 and PAR-3) and the P1 cell ( ... the P2 cell instructs the EMS cell to divide along the anterior-posterior axis. Through Notch signaling, the P2 cell ...

https://en.wikipedia.org/wiki/Caenorhabditis_elegans

Asymmetric cell division has also been described in polyploid giant cancer cells and low eukaryotic cells and reported to occur ... "Asymmetric cell division in polyploid giant cancer cells and low eukaryotic cells". BioMed Research International. 2014: 432652 ... A word of caution: some examples of cell division formerly thought to belong to this "non-mitotic" class, such as the division ... Amitosis (a- + mitosis), also called karyostenosis or direct cell division or binary fission, is cell proliferation that does ...

https://en.wikipedia.org/wiki/Amitosis

They achieve this divergence through asymmetric cell division. The mitotic asymmetry with non-random segregation of chromosomes ... Since meiosis II is not associated with cell division here, and since the two daughter formations of the first division also ... Non-random segregation of chromosomes is also found in mitosis when stem cells divide. Adult stem cells maintain the mature ... Only from this cell do two sperm cells emerge after meiosis II, while the smaller cell degenerates. Thus, each sperm - like the ...

https://en.wikipedia.org/wiki/Non-random_segregation_of_chromosomes

They are multipolar cells produced by radial glial cells who have undergone asymmetric division. IPCs can produce neuron cells ... The asymmetric division of radial glial cells and the subsequent symmetric division of intermediate progenitor cells may be the ... When radial glial cells divide, they produce one replacement radial glial cell and one IPC. That IPC can then divide to form ... suggesting it plays some role in the mechanism for division. Progenitor cell Neurogenesis Radial glial cell Kowalczyk, Tom; ...

https://en.wikipedia.org/wiki/Intermediate_progenitor_cell

... which begin with either a symmetric or an asymmetric division of the initial cell. Symmetric division leads to the development ... siliculosus gametophytes have an asymmetric initial cell division and immediate differentiation of an erect thallus. The ... cells) which is a filament with E cells on the edges and R cells in the center. Then, there is a period of secondary growth in ... Asymmetric division leads to the immediate development of an erect thallus without the formation of a prostrate, basal ...

https://en.wikipedia.org/wiki/Ectocarpus_siliculosus

Asymmetric cell division: a stem cell divides into one mother cell, which is identical to the original stem cell, and another ... stem cells undergo two types of cell division (see Stem cell division and differentiation diagram). Symmetric division gives ... Cell bank Human genome Meristem Mesenchymal stem cell Ovarian stem cell Partial cloning Plant stem cell Stem cell controversy ... Asymmetric division, on the other hand, produces only one stem cell and a progenitor cell with limited self-renewal potential. ...

https://en.wikipedia.org/wiki/Stem_cell

"Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system". Nature ... Neural stem cells divide in a self-renewing manner, generating daughter cells that give rise to different types of neurons. The ... she has explained how cell fate determinants become localised to one side of a cell, allowing neural precursors to divide ... One protein, known by the name Prospero, is responsible for regulating stem cells to produce cells which produce neurons. ...

https://en.wikipedia.org/wiki/Andrea_Brand

Aside from microtubules it also contains various proteins involved in cytokinesis, asymmetric cell division, and chromosome ... This endosome is marked by MKLP1, and can persist for up to 48 hours once internalised into another cell. It is coated in Actin ... The midbody is a transient structure found in mammalian cells and is present near the end of cytokinesis just prior to the ... Iwamori T, Iwamori N, Ma L, Edson MA, Greenbaum MP, Matzuk MM (May 2010). "TEX14 interacts with CEP55 to block cell abscission ...

https://en.wikipedia.org/wiki/Midbody_(cell_biology)

Lin H, Spradling AC (1997). "A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the ... But studies have reported that piRNA expression can be found in the ovarian somatic cells and neuron cells in invertebrates, as ... Piwi (or PIWI) genes were identified as regulatory proteins responsible for stem cell and germ cell differentiation. Piwi is an ... "piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells". Development ...

https://en.wikipedia.org/wiki/Piwi

... alongside other molecules that also play a role in the process of asymmetric cell division. Since stem cell mitosis is a highly ... "Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization". Cell. 135 (1 ... "Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization". Cell. 135 (1 ... Asymmetric cell division is based on a reaction cascade in which a cascade of molecular switches are activated or inactivated. ...

https://en.wikipedia.org/wiki/Jürgen_Knoblich

... while the pIIb cell divides to produce a neuron and a glial cell. The asymmetric division of the SOP into daughter cells with ... The posterior daughter cell is called the pIIa cell and the anterior daughter cell is called the pIIb. The pIIa cell divides to ... This asymmetric division allows a daughter cell containing Numb to acquire a different fate than the other daughter cell. The ... Roegiers F, Jan YN (April 2004). "Asymmetric cell division". Curr. Opin. Cell Biol. 16 (2): 195-205. doi:10.1016/j.ceb.2004.02. ...

https://en.wikipedia.org/wiki/NUMB_(gene)

Cell polarity is a prerequisite for several fundamental operations in animal cells, such as asymmetric cell division and ... Cell and Developmental Biology, or CDB, is built on the idea that the cell should be the primary focus of developmental biology ... Stem cell research includes differentiation and transdifferentiation in the hematopoietic system, somatic cell reprogramming, ... stem cell differentiation, organoid formation, and induced pluripotent stem cells. This unit collaborates with the Biomolecular ...

https://en.wikipedia.org/wiki/Centre_for_Genomic_Regulation

The asymmetric division of daughter cells results in the unequal division of both cytoplasm and nucleoplasm. Scientists believe ... During cell division, organelles divide synchronously before nuclear division. Cell division is aided by a phycoplast, which is ... Asymmetric cell division clearly plays an important role in the production of phenotypically diverse cells in multicellular ... For example, the species T. indica is being used to study how asymmetric cell-division during mitosis results in clonal cell ...

https://en.wikipedia.org/wiki/Tetraselmis

Beta-catenin has also been implicated in regulation of cell fates through asymmetric cell division in the model organism C. ... Sawa H (2012). "Control of cell polarity and asymmetric division in C. elegans". Planar Cell Polarity During Development. ... December 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". Journal of Cell Science. ... These cell-cell adhesion complexes are necessary for the creation and maintenance of epithelial cell layers and barriers. As a ...

https://en.wikipedia.org/wiki/Catenin_beta-1

Conversely, asymmetric cell division is expected to result in parent and daughter cells with different INM profiles. The INM ... Thus, the Nuclear Scaffold Theory predicts that symmetric cell division occurs when a daughter cell contains the same ... CD4+ TH1 and TH2 helper T-cells) is expected to be more similar than for cells that are more distantly related (e.g., T-cells ... complementarity to TH1 helper T-cells will be: TH2 > CD8+ > B-cell > Erythrocyte > cardiomyocyte). Some cells that are very ...

https://en.wikipedia.org/wiki/Inner_nuclear_membrane_protein

It disassembles during cell division and reforms in the daughter cells in an asymmetric fashion in relation to the cytoskeleton ... This asymmetric positioning of the eyespot in the cell is essential for proper phototaxis. The most critical eyespot proteins ... occurs when cells are briefly exposed to high light intensity, causing the cell to stop, briefly swim backwards, then change ... It allows the cells to sense light direction and intensity and respond to it, prompting the organism to either swim towards the ...

https://en.wikipedia.org/wiki/Eyespot_apparatus

Cell interactions in the asymmetric division of stem cells. Michael Goldstein, Professor of Mathematics, University of Toronto ... Engineering stem cell fate. Shoucheng Zhang, Professor of Physics, Stanford University: Quantum spin Hall effect. Lisa Zunshine ...

https://en.wikipedia.org/wiki/List_of_Guggenheim_Fellowships_awarded_in_2007

... asymmetric cell division, and cellular differentiation. Caulobacter daughter cells have two very different forms. One daughter ... Swarmer cells differentiate into stalked cells after a short period of motility. Chromosome replication and cell division only ... TipN localizes to the new pole in both daughter cells after division and relocalizes to the cell division site in the late ... as it orchestrates activation of cell cycle subsystems and Caulobacter crescentus asymmetric cell division. The proteins of the ...

https://en.wikipedia.org/wiki/Caulobacter_crescentus

At a certain point, a neuroblast will undergo asymmetric cell division giving rise to a neuroblast and a ganglion mother cell. ... Ganglion mother cells (GMCs) are cells involved in neurogenesis, in non-mammals, that divide only once to give rise to two ... While each ganglion mother cell necessarily gives rise to two neurons, a neuroblast can asymmetrically divide multiple times. ... Ohshiro, T., Yagami, T., Zhang, C., & Matsuzaki, F. (2000). Role of cortical tumour-suppressor proteins in asymmetric division ...

https://en.wikipedia.org/wiki/Ganglion_mother_cell

... has been shown to eliminate toxic proteins in JUNQ and IPOD inclusion bodies in asymmetric division of mammalian cell ... With the blocking of transport of LDL-derived cholesterol inside the cell, cells were found to store a much lower percentage of ... Because of this, vimentin is often used as a marker of mesenchymally-derived cells or cells undergoing an epithelial-to- ... "Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of ...

https://en.wikipedia.org/wiki/Vimentin

... cells upon cell division, with the mother cell experiencing aging, while the daughter is rejuvenated. There is negligible ... Ackermann M, Stearns SC, Jenal U (June 2003). "Senescence in a bacterium with asymmetric division". Science. 300 (5627): 1920. ... Cloning from somatic cells rather than germ cells may begin life with a higher initial load of damage. Dolly the sheep died ... Senescent cells within a multicellular organism can be purged by competition between cells, but this increases the risk of ...

https://en.wikipedia.org/wiki/Senescence

Nextstrain divides the variants into five clades (19A, 19B, 20A, 20B, and 20C), while GISAID divides them into seven (L, O, V, ... The SARS-CoV-2 virus can infect a wide range of cells and systems of the body. COVID‑19 is most known for affecting the upper ... Bilateral multilobar ground-glass opacities with a peripheral, asymmetric, and posterior distribution are common in early ... The cells of the central nervous system, the microglia, neurons, and astrocytes, are also involved in the release of pro- ...

https://en.wikipedia.org/wiki/COVID-19

In 2005, as head of the division of medicine at UCL, he published a paper in the Journal of the Royal Society of Medicine, ... The following year they reported that the plasma concentrations of asymmetric dimethylarginine (ADMA) were elevated in people ... where his research concentrated on vascular biology and endothelial cell physiology. In 1995, he was appointed Professor at UCL ... where his research concentrated on vascular biology and endothelial cell physiology. Prior to the discovery of the involvement ...

https://en.wikipedia.org/wiki/Patrick_Vallance

The Haqqani network is an Afghan Islamist group, built around the family of the same name, that has used asymmetric warfare in ... "Trump's bombast further divides Afghanistan and Pakistan, as civilians await meaningful change". Nichols, Phil Stewart, ... the Pashto-language book details instructions on setting up a jihadi cell, receiving financing, recruiting and training. The ...

https://en.wikipedia.org/wiki/Haqqani_network

Stavridis, James G.; Weinstein, Dave (24 October 2013). "Divide and Conquer". Foreign Affairs. Retrieved 27 November 2016. {{ ... we will be beholden to perpetrators of asymmetric cyberwarfare." On June 20, 2016 New Jersey Governor Chris Christie named ... "spearheaded the implementation of Governor Christie's New Jersey Cybersecurity and Communications Integration Cell, the State's ...

https://en.wikipedia.org/wiki/Dave_Weinstein

M cells) that allow for the uptake of antigens produced by pathogens. These M cells then alert the B cells and T cells in the ... In older patients, asymmetric tonsils (also known as asymmetric tonsil hypertrophy) may be an indicator of virally infected ... Division of Otolaryngology, Nemours-AI duPont Hospital for Children "Tonsils , Tonsilitis , Lymph Nodes , MedlinePlus". ... The tonsils have on their surface specialized antigen capture cells called Microfold cell ( ...

https://en.wikipedia.org/wiki/Tonsil

"Asymmetric cell division: recent developments and their implications for tumour biology". Nature Reviews. Molecular Cell ... Yang H, Ganguly A, Cabral F (October 2010). "Inhibition of cell migration and cell division correlates with distinct effects of ... Forth S, Kapoor TM (June 2017). "The mechanics of microtubule networks in cell division". The Journal of Cell Biology. 216 (6 ... Some cell types, such as plant cells, do not contain well defined MTOCs. In these cells, microtubules are nucleated from ...

https://en.wikipedia.org/wiki/Microtubule

Cell. 185 (8): 1402-1413.e21. doi:10.1016/j.cell.2022.03.007. ISSN 0092-8674. PMC 9042794. PMID 35366416. S2CID 247859905. ... These bows were typified by being asymmetric in cross-section between 145 and 155 cm (57 and 61 in) in length, having between 4 ... And as they are lightly equipped for swift motion, and unexpected in action, they purposely divide suddenly into scattered ...

https://en.wikipedia.org/wiki/Huns

When this is not possible, as with most asymmetric tops, all that can be done is to fit the spectra to three moments of inertia ... A convenient way to look at the molecules is to divide them into four different classes, based on the symmetry of their ... A simple section of waveguide can serve as an absorption cell. An important variation of the technique in which an alternating ... For asymmetric tops a single isotopologue provides information for at most 3 molecular parameters. Such transitions are called ...

https://en.wikipedia.org/wiki/Rotational_spectroscopy

The division of EW known as ECM can take action to prevent or reduce an enemy's effective use of the electromagnetic spectrum ... Fusion cells will produce IED trend reporting and intelligence reports to feed current operations or prosecuting follow-on ... Because IEDs are a subset of a number of forms of asymmetric warfare used by insurgents and terrorists, C-IED activities are ... The division of EW known as electronic support measures can search for, identify and intercept, electromagnetic emissions and ...

https://en.wikipedia.org/wiki/Counter-IED_efforts

Scientific Affairs Division. pp. 375-384. ISBN 978-0-792-34768-2. Lukacs, Yehuda (1999). Israel, Jordan, and the Peace Process ... West Bank Palestinians have engaged in two uprisings that have led to an asymmetric set of wars of attrition, between the ... Collaborators (asafir), broken in interrogation, and then planted in cells to persuade other prisoners to confess, began to be ... This characterization has been further refined by classifying the conflict as structurally asymmetric, where the root cause of ...

https://en.wikipedia.org/wiki/Israeli_occupation_of_the_West_Bank

Sharma, Ajay K; Sinha, R K; Agarwala, R A (2015). "Wavelength Division Multiplexing Systems and Networks". IETE Technical ... which has been effectively used for label free classification and detection of cancer cell. Field Emission characteristics of ... "Characterisation of Single-Mode Asymmetric Slab Waveguide from Far Field Intensity Pattern". Journal of Optical Communications ... Rani, Preeti; Kalra, Yogita; Sinha, R. K. (2015). "Slow light enabled time and wavelength division demultiplexer in slotted ...

https://en.wikipedia.org/wiki/Ravindra_Kumar_Sinha_(physicist)

During World War II, he was head of the Theoretical Division at the secret Los Alamos laboratory which developed the first ... He developed the Fischer projection, a symbolic way of drawing asymmetric carbon atoms. He is known for study of sugars & ... Paul Langerhans: Islets of Langerhans, Langerhans cells Max von Laue: Discoveries regarding the diffraction of X-rays in ... Theodor Schwann: Discovery of properties of cells in animals. Karl Schwarzschild: astronomer, Schwarzschild metric, Deriving ...

https://en.wikipedia.org/wiki/List_of_German_inventors_and_discoverers

"Red cell, plasma and blood volume in healthy men measured by radiochromium (Cr51) cell tagging and hematocrit: influence of age ... The corpus callous is located at the sagittal divide and is the primary commissure in the human brain. It connects the left and ... Typically, male brains are more asymmetric than female brains. Females have less asymmetry than males between left and right ... Sex hormones may influence female hippocampal cells to tolerate brain damage better than the same cells in men. The studies of ...

https://en.wikipedia.org/wiki/Sex_differences_in_human_physiology

Cells called guidepost cells assist in the guidance of neuronal axon growth. These cells that help axon guidance, are typically ... An axon can divide into many branches called telodendria (Greek for 'end of tree'). At the end of each telodendron is an axon ... Da Silva JS, Hasegawa T, Miyagi T, Dotti CG, Abad-Rodriguez J (May 2005). "Asymmetric membrane ganglioside sialidase activity ... Depending on the type of receptors that are activated, the effect on the target cell can be to excite the target cell, inhibit ...

https://en.wikipedia.org/wiki/Axon

Time-Division Synchronous Code-Division Multiple Access (TD-SCDMA) or UTRA TDD 1.28 Mcps low chip rate (UTRA-TDD LCR) is an air ... Flexible RLC Dual-Cell HSDPA Dual-Cell HSUPA List of UMTS networks 3GPP: the body that manages the UMTS standard. 3GPP Long ... the system can more easily accommodate asymmetric traffic with different data rate requirements on downlink and uplink than FDD ... TD-CDMA, an acronym for Time-Division-Code-Division Multiple Access, is a channel-access method based on using spread-spectrum ...

https://en.wikipedia.org/wiki/UMTS

... leading to an abundance of monopolar or asymmetric spindles, preventing cells from entering mitosis. NEDD9 also regulates ... Browne CD, Hoefer MM, Chintalapati SK, Cato MH, Wallez Y, Ostertag DV, Pasquale EB, Rickert RC (2010). "SHEP1 partners with ... Tikhmyanova N, Tulin AV, Roegiers F, Golemis EA (2010). "Dcas supports cell polarization and cell-cell adhesion complexes in ... points of dialog between the cell cycle and cell attachment signaling networks". Cell Cycle. 5 (4): 384-91. doi:10.4161/cc.5.4. ...

https://en.wikipedia.org/wiki/NEDD9

Koch AL (1984). "Primeval cells: possible energy-generating and cell-division mechanisms". J. Mol. Evol. 21 (3): 270-7. Bibcode ... "The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze- ... These membranes are flat sheets that form a continuous barrier around all cells. The cell membranes of almost all organisms and ... This procedure is now used extensively, for example by fusing B-cells with myeloma cells. The resulting "hybridoma" from this ...

https://en.wikipedia.org/wiki/Lipid_bilayer

In other words, V − = A {\displaystyle \,\!V_{-}=A} where A is a constant and d V − d t = 0 {\displaystyle {\frac {dV_{-}}{dt ... For example, geothermal geysers, networks of firing nerve cells, thermostat controlled heating systems, coupled chemical ... When Vss is not the inverse of Vdd we need to worry about asymmetric charge up and discharge times. Taking this into account we ... dV_{-}}{dt}}+{\frac {V_{-}}{RC}}=0} results in V − = B e − 1 R C t {\displaystyle V_{-}=Be^{{\frac {-1}{RC}}t}} V − {\ ...

https://en.wikipedia.org/wiki/Relaxation_oscillator

The divide over Hezbollah followed mostly sectarian lines, with Shias largely supporting the group and Sunnis, Christians and ... Hillel Fendel (8 August 2006). "Heavy Fighting in Southern Lebanon; Sleeping Terror Cell Caught". Israel National News. ... and Blackmail in an Age of Asymmetric Conflict. Cambridge University Press. p. 171. ISBN 978-0-521-86615-6. Israel/Lebanon: Out ... The study was supported by Military Intelligence, the Operations Division of the IDF General Staff, the IDF Spokesperson and ...

https://en.wikipedia.org/wiki/2006_Lebanon_War

This stratified squamous epithelium is maintained by cell division within the stratum basale, in which differentiating cells ... Alphavirus infection Asymmetric periflexural exanthem of childhood (unilateral laterothoracic exanthem) B virus infection ... pale cell acanthoma) Clear cell squamous cell carcinoma (clear cell carcinoma of the skin) Chronic scar keratosis (chronic ... Solitary trichoepithelioma Spindle cell squamous cell carcinoma (spindle cell carcinoma) Spiradenoma Squamous cell carcinoma ...

https://en.wikipedia.org/wiki/List_of_skin_conditions

Instead, chickens establish LR asymmetry through asymmetric cell rearrangements which results in a leftward movement of cells ... As the embryo divides, quartets of cells are oriented at angles to each other. In the snail Lymnaea stagnalis, the direction of ... Kurita, Yoshihisa; Wada, Hiroshi (2011-04-27). "Evidence that gastropod torsion is driven by asymmetric cell proliferation ... "Cell Movements at Hensen's Node Establish Left/Right Asymmetric Gene Expression in the Chick". Science. 324 (5929): 941-944. ...

https://en.wikipedia.org/wiki/Left-right_asymmetry

"Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates". Cell. 107 (6): 739-50. doi: ... As these types of chitinases are important in cell division, there must be tight regulation and activation. Specifically, Cts1 ... However, chitinases that have specialized functions, such as degrading exogenous chitin or participating in cell division, need ... regulatory networks allows for the cell wall degrading chitinase to function dependent on the cell's stage in the cell cycle ...

https://en.wikipedia.org/wiki/Chitinase

"Caltech Division of Engineering and Applied Science , News , Professor Yu-Chong Tai Elected to the National Academy of ... and Cell and Molecular Biology at Northwestern University and Howard Hughes Medical Institute investigator Daniel G. Nocera, ... "for the development of asymmetric organocatalysis." Rudolph Marcus, Nobel laureate in chemistry (1992) "for his contributions ... Director of Physics Division at Lawrence Berkeley National Lab; member of National Academy of Sciences Virginia Louise Trimble ...

https://en.wikipedia.org/wiki/List_of_California_Institute_of_Technology_people

In the anaphase of mitosis, sister chromatids separate and migrate to opposite cell poles before the cell divides. ... Affected individuals may have a patchy or asymmetric appearance. Examples of mosaicism syndromes include Pallister-Killian ... mitosis is the form of cell division used by all other cells of the body. Ovulated eggs become arrested in metaphase II until ... Such a cell is said to be aneuploid. Loss of a single chromosome (2n-1), in which the daughter cell(s) with the defect will ...

https://en.wikipedia.org/wiki/Nondisjunction

Asymmetric Cell Division, Cell Differentiation, Cell Division, Centrosome, cytoskeleton, Humans, Spindle Apparatus, Stem Cells ... Home » Control of asymmetric cell division.. Control of asymmetric cell division.. Submitted by Clemens-Cabernard on Sun, Sep ... Asymmetric cell division (ACD) is a mechanism to generate cellular diversity and used by prokaryotes and eukaryotes alike. Stem ... Similarly, many cell types also generate physical asymmetry in the form of sibling cell size differences. Emerging data ...

https://www.biology.washington.edu/pubs/control-asymmetric-cell-division

B cells and T cells that the generation of these cell types may be accomplished simultaneously through asymmetric cell division ... The second chapter of this thesis focuses on what factors may drive the divergence of cell fates in asymmetric cell division of ... we extend our interrogation of asymmetric cell division in lymphocytes to the development of regulatory T cells, which are ... We propose that this overlap may be a result of an asymmetric cell division, giving rise to one Treg and one conventional CD4+ ...

https://academiccommons.columbia.edu/doi/10.7916/D8NP3GB7

Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo. / Gurevich, David B.; Nguyen, Phong ... Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo. In: Science. 2016 ; Vol. 353, No. 6295 ... Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo. Science. 2016 Jul 8;353(6295). aad9969 ... Dive into the research topics of Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo. ...

https://researchportal.bath.ac.uk/en/publications/asymmetric-division-of-clonal-muscle-stem-cells-coordinates-muscl

Asymmetric cell division: Miranda chauffeured by jaguar? / Tuxworth, R.; Chia, W.. In: Molecular Cell, 2003.. Research output: ... Tuxworth R, Chia W. Asymmetric cell division: Miranda chauffeured by jaguar? Molecular Cell. 2003. doi: 10.1016/S1097-2765(03) ... Tuxworth, R. ; Chia, W. / Asymmetric cell division: Miranda chauffeured by jaguar?. In: Molecular Cell. 2003. ... Tuxworth, R., & Chia, W. (2003). Asymmetric cell division: Miranda chauffeured by jaguar? Molecular Cell. https://doi.org/ ...

https://research.birmingham.ac.uk/en/publications/asymmetric-cell-division-miranda-chauffeured-by-jaguar

... of GPCR-independent activation of Gα subunits by the guanine nucleotide exchange factor RIC-8 in both asymmetric cell division ... where Numb influences cell fate by repressing Notch signaling. Asymmetric localization of both proteins requires the protein ... lateral transport along the cell cortex has been proposed as a possible mechanism for their asymmetric distribution [5]. ... proteins control both intercellular signaling and asymmetric cell divisions by distinct pathways. The classical pathway, found ...

https://www.cell.com/current-biology/issue?pii=S0960-9822

Modeling Tissue Organization Based on Asymmetric Cell Division. Post navigation. The Effects of UV-filters on the Survival, ...

https://www.urp.udel.edu/summer-sym-pres/modeling-tissue-organization-based-on-asymmetric-cell-division/

Asymmetric division is a property of stem cells that leads to the generation of two cells that can adopt different fates. One ... Ultimately, asymmetric divisions are regulated directly by genes that control the process of asymmetric cell division itself or ... 2. Drosophila germline stem cells. Asymmetric division of germline stem cells (GSCs) in Drosophila melanogaster is highly ... Rusan, N.M. Peifer, M. (2007). A role for a novel centrosome cycle in asymmetric cell division. J Cell Biol 177, 13-20. ...

https://www.stembook.org/node/562

A guiding torch at the poles: key roles of the centrosome during asymmetric cell division. Add to your list(s) Download to your ... Centrosomes and SPBs play a particularly relevant role in cells that display an asymmetric division, since these structures can ... key roles of the centrosome during asymmetric cell division ... of key cellular processes during asymmetric cell division, as ... The distribution of the duplicated genome during cell division is facilitated by the spindle, a remarkable and complex cellular ...

https://www.talks.cam.ac.uk/talk/index/161320

Molecular mechanisms underlying asymmetric cell division. MBBB481/2/3. Dr. Fiona Brinkman. Multiple bioinformatics projects: ... Molecular mechanisms underlying asymmetric cell division. MBB 481/2/3. Dr. Nancy Hawkins. ... The Hawkins lab studies the role of asymmetrically localized proteins and the Wnt signaling pathway in asymmetric cell division ... The goal is to watch the segregation of HAM-1 in living embryos during cell division. To accomplish this goal, the directed ...

http://www.sfu.ca/mbb/undergrad/current-students/research/volunteering.html

involved_in male germ-line stem cell asymmetric division ISS Inferred from Sequence or Structural Similarity. more info ... Title: miR‑92a contributes to cell proliferation, apoptosis and doxorubicin chemosensitivity in gastric carcinoma cells. ... A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2. Temel M, et al. Tumour Biol, 2015 Jun. ... It was concluded that ING2 not only plays an essential role in the growth and invasion of MGC-803 cells but also represents a ...

https://www.ncbi.nlm.nih.gov/gene/3622

Cancer stem cells promote neoplastic growth, in part by deregulating asymmetric cell division and enhancing self-renewal. To ... Finally, our TCGA GBM data analysis revealed that CDK5, stem cell, and asymmetric cell division markers segregate within non- ... Human neuroglial cells internalize Borrelia burgdorferi by coiling phagocytosis mediated by Daam1External. Williams SK, Weiner ... The ability of B. burgdorferi to invade or be internalized by host cells in vitro has been proposed as a mechanism for the ...

https://www.cdc.gov/library/sciclips/issues/v10issue18.html

Mora-Bermudez, F.; Huttner, W. B.: Centrosomes in asymmetric cell division and neocortical development. In: Encyclopedia of ... Schmidt, U.; Weigert, M.; Broaddus, C.; Myers, G.: Cell Detection with Star-Convex Polygons. In: Medical Image Computing and ... Mittasch, M.: Light-driven intracellular flow perturbations reveal physical principles of cell organization. Dissertation, ... Model-Based Generation of Synthetic 3D Time-Lapse Sequences of Multiple Mutually Interacting Motile Cells with Filopodia. In: ...

https://www.mpg.de/14602643/publications?page=9&year=2018

Asymmetric (Uninflatable?) endosomes during asymmetric cell division in Drosophila Wednesday 2 February 2011 13:00 seminar room ... Sara-binding Proteins and their Role during asymmetric Cell Division Friday 17 December 2010 15:15 lecture theatre. K. H. Meyer ... Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany Blebs and lamellipodia formation during cell ... Cell cycle control in the wing disc : from static to live imaging Wednesday 9 March 2011 13:00 seminar room. 352. Sciences II ...

http://www.unige.ch/sciences/chifi/Vauthey/seminars.php?lang=en&yr=2010&wid=1&nocolors=&pres=tabl&dept=all

Mechanical regulation of cell size, fate, and behavior during asymmetric cell division. Delgado MK, Cabernard C. Delgado MK, et ... Epub 2020 Aug 5. Curr Opin Cell Biol. 2020. PMID: 32768924 Free PMC article. Review. ... al. Curr Opin Cell Biol. 2020 Dec;67:9-16. doi: 10.1016/j.ceb.2020.07.002. ...

https://pubmed.ncbi.nlm.nih.gov/?cmd=search&term=Delgado+MK%5Bau%5D&dispmax=50

doi: 10.1016/j.cell.2013.07.014. PubMed PMID: 23953115.. Regulation of asymmetric cell division and polarity by Scribble is not ... The Analysis of Cell Cycle, Proliferation and Asymmetric Cell Division by Imaging Flow Cytometry. Andrew Filby, William Day, ... Asymmetric segregation of polarized antigen on B cell division shapes presentation capacity.. Thaunat O, Granja AG, Barral P, ... An imaging flow cytometric method for measuring cell division history and molecular symmetry during mitosis.. Filby A, Perucha ...

https://www.ncl.ac.uk/fccf/publications/

Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation. Khanna, Kanika Lopez-Garrido, ... the division septum is formed at the midcell to produce two equal daughter cells. However, during sporulation, the division ... The Gram-positive bacterium Bacillus subtilis can divide via two modes. During vegetative growth, ... septum is formed closer to one pole to yield a smaller forespore and a larger mother cell. Using cryo-electron tomography, ...

https://www.mysciencework.com/publication/facets/keywords/Operon

Centrosomes in asymmetric cell division. Gonzalez C. Current Opinion In Structural Biology ... Illuminati: a form of gene expression plasticity in Drosophila neural stem cells ...

https://www.irbbarcelona.org/ca/research/serena-mahnoor

... immune cells, and heart cells, to name a few. Incredibly, all of these cell types come from a single fertilized cell called a ... Multicellular organisms are made up of a variety of different types of cells that perform different functions. Even something ... seemingly as simple as the marine invertebrate Ciona robusta, more commonly known as the sea squirt, has muscle cells, ... Different rates of receptor recycling and breakdown influence asymmetric cell division. Multicellular organisms are made up of ...

https://www.swarthmore.edu/senior-showcase/camryn-slosky-22

Asymmetric cell division and division polarity of stomata in Arabidopsis. The asymmetric divisions of MMCs with and without ... Asymmetric cell division and division polarity of stomata in Arabidopsis. The asymmetric divisions of MMCs with and without ... but then condenses into a discrete crescent just before the mother cell undergoes an asymmetric cell division. When a cell ... cell-cell communication, asymmetric and stem cell-like divisions, and the creation of cell polarity (Bergmann and Sack, 2007; ...

https://journals.biologists.com/dev/article/139/20/3683/45341/Stomatal-development-a-plant-s-perspective-on-cell

Regulation of cell and tissue architecture in epidermal morphogenesis and homeostasis ... They couple intercellular communication to cell identity, shape, migration, and asymmetric versus symmetric division. We ask ... Epidermal aPKCι/λ disturbs epidermal barrier function and alters cell fate in the epidermis as a result of increased asymmetric ... We focus mainly on the stratifying epithelia of the skin using transgenic and conditional mouse models as well as cells ...

https://www.uib.no/en/biomedisin/70174/bbb-seminar-carien-m-niessen

Read the latest Research articles in Cell biology from Nature Communications ... The polarization of distinct scaffold-signaling hubs at opposite cell poles constitutes the basis of asymmetric cell division. ... The cell wall and cytoplasmic MreB polymers are important for bacterial cell shape. However, Spiroplasma cells lack a cell wall ... Here, the authors develop a culture platform that can dynamically mimic the cell-cell and cell-extracellular matrix ...

https://www.nature.com/subjects/cell-biology/ncomms?error=cookies_not_supported&code=15d57fcf-584d-4970-9efe-e83a31a8e62f

Spatial perturbation with synthetic protein scaffold reveals robustness of asymmetric cell division (Articles) ...

https://scirp.org/journal/articles.aspx?searchcode=Charles+Bu&searchfield=authors&page=1&skid=0

... and the molecular network controlling cell polarity and asymmetric cell division. ... REGULATES SPINDLE ORIENTATION; ASYMMETRIC CELL-DIVISION; SELF-RENEWAL; PROSPERO GENE; C-MYC; ACETYLTRANSFERASE COMPLEX; ... but whether these factors control stem cell polarity and asymmetric division has not been investigated so far. We addressed ... Stem cells establish cortical polarity and divide asymmetrically to simultaneously maintain themselves and generate ...

https://kups.ub.uni-koeln.de/17644/

Twins Separated at Birth: Polarized Protein Translation and Asymmetric Cell Division in T Cells ... Cell Fate in Immunity and Metabolic Disease Discussion Leader: Lisa Bouchier-Hayes (Baylor College of Medicine, United States) ... Immune Cell Metabolism in Patients vs. In Vitro: Developing Marker Strategies to Link Drug Targets with Disease ... Despite recent advances, it is increasingly recognized that our understanding of the metabolic wiring of immune cells is still ...

https://www.grc.org/immunometabolism-in-health-and-disease-conference/2022/

At the brain level SPAG5 helps PAX6 to regulate the sequential symmetric and asymmetric cell division of neuronal precursors. ... 2011). The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex. ... 2013). Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell 154, 859-874. doi: 10.1016/j ... Pax6 regulates the orientation and mode of cell division of progenitors in the mouse cerebral cortex, influencing as it does ...

https://www.frontiersin.org/articles/10.3389/fpsyg.2015.00794/full

EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells. Cancer Res. 2016 11 01; 76( ... Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells. Stem Cells ... Approaches to studying cell adhesion molecules in angiogenesis. Trends Cell Biol. 1995 Feb; 5(2):69-74. PMID: 14731415. ... Hemogenic endothelial progenitor cells isolated from human umbilical cord blood. Stem Cells. 2007 Nov; 25(11):2770-6. PMID: ...

https://connects.catalyst.harvard.edu/Profiles/display/Person/63431

Hermann, Andrea (2010): Analysis of asymmetric division of hematopoietic stem cells by continuous single cell observation. ...

https://edoc.ub.uni-muenchen.de/view/autoren/Hermann=3AAndrea=3A=3A.html

... with cell geometry modulating the effect of cortical polarity domains by influencing the position of the spindle relative to ... Cell geometry and polarity domains act in concert to determine spindle positioning, ... with asymmetric segregation of determinants leading to asymmetric cell division creating sibling cells with different cell ... Unequal cell division is the key developmental process by which one cell divides into two daughter cells of different sizes. ...

https://elifesciences.org/articles/75639

SOP cells are one of the best characterized model systems for asymmetric cell division as they generate the four different cell ... reveals the asymmetric segregation of cell fate determinants during the division of these cells. The area in between SOP cells ... Cell 132, 583-597.. Neumuller, R.A., and Knoblich, J. A. (2009). Dividing cellular asymmetry: asymmetric cell division and its ... movie of a single dividing SOP cell highlights the dynamics of cell fate determinants during asymmetric cell division. Prior to ...

https://www.oeaw.ac.at/imba/research/juergen-knoblich/resources

Recent in vitro studies have highlighted a role for asymmetric divisions in renewing rare "immortal" stem cells and generating a clonal population of differentiation-competent myoblasts. (bath.ac.uk)
Asymmetric localization of cell-cell junctions and/or intrinsic cell fate determinants and position within specific environment ("niche") are examples of mechanisms used to specify cell polarity and direct asymmetric divisions. (stembook.org)
During development, asymmetric divisions provide the basis for establishment of the body axis and cell fate determination in a range of processes. (stembook.org)
Subsequently, asymmetric cell divisions play a critical role in maintaining adult stem cell populations, while at the same time generating an adequate number of differentiating daughter cells to maintain tissue homeostasis and repair. (stembook.org)
Loss of cell polarity, and consequently the potential for asymmetric divisions, is often linked to excessive stem cell self-renewal and tumorigenesis. (stembook.org)
Here we will discuss multiple factors and mechanisms that imbue cells with polarity to facilitate an asymmetric outcome to stem cell divisions, assuring self-renewal and maintenance of the stem cell pool. (stembook.org)
Ultimately, asymmetric divisions are regulated directly by genes that control the process of asymmetric cell division itself or determine the distinct cell fates of the two daughter cells. (stembook.org)
Interestingly, spindle MTO Cs themselves can be non-randomly inherited during asymmetric cell divisions, an evolutionary process that we have recently demonstrated to be important for the maintenance of a full replicative lifespan in budding yeast. (cam.ac.uk)
The plant stomatal lineage manifests features common to many developmental contexts: precursor cells are chosen from an initially equivalent field of cells, undergo asymmetric and self-renewing divisions, communicate among themselves and respond to information from a distance. (biologists.com)
Epidermal aPKCι/λ disturbs epidermal barrier function and alters cell fate in the epidermis as a result of increased asymmetric divisions in stem and progenitor cell populations. (uib.no)
Using the early embryonic divisions of the ascidian Phallusia mammillata as a model to investigate mechanisms of unequal cell division, this study convincingly demonstrates that cell shape and cortical domains are cooperating, rather than competing, in order to establish cell size asymmetry, a significant conceptual advance for the field. (elifesciences.org)
Yet, whether and how cell geometry and polarity domains compete with each other not only to determine the orientation but also the centering of the mitotic spindle leading to equal or unequal cell divisions (UCDs) remains unclear. (elifesciences.org)
Differential routing of Mindbomb1 via centriolar satellites regulates asymmetric divisions of neural progenitors. (ens.fr)
Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development. (ens.fr)
In most dicot plants, lateral root (LR) formation, which is important for the construction of the plant root system, is initiated from coordinated asymmetric cell divisions (ACD) of the primed LR founder cells in the xylem pole pericycle (XPP) of the existing roots. (biologists.com)
In addition, XPP-specific expression of LBD16/ASL18 in arf7 arf19 induced cell divisions at XPP, thereby restoring the LR phenotype. (biologists.com)
DNA is continuously and progressively demethylated across cell divisions in replicating PGCs, whereas in the embryo the patterns change drastically after the first cell division and remain unchanged over the next three divisions. (epigenie.com)

They couple intercellular communication to cell identity, shape, migration, and asymmetric versus symmetric division. (uib.no)
Knockdown of Tip60 complex members results in loss of cortical polarity, symmetric neuroblast division, and premature differentiation through nuclear entry of the transcription factor Prospero. (uni-koeln.de)
With the help of the Cyclotron accelerator at VECC, Kolkata, we use nuclear reactions with energetic light- and heavy-mass projectiles, to excite different modes in deformed (both axially symmetric and axially asymmetric) nuclei and identify them by detecting the gamma rays, they emit, in an array of clover HPGe detectors, a state-of-the-art modern semiconductor detector for the detection of gamma rays. (jcbose.ac.in)
This technique, previously developed by the same researchers, lets you examine whether DNA methylation is symmetric across complementary strands at CpGs, therefore allowing for some detailed stem cell division methylation dynamics . (epigenie.com)
Overall, the group concludes that the main driver of DNA demethylation in germ cells is the impairment of the maintenance of symmetric CpG sites. (epigenie.com)
in 2 cases, LSs were symmetric with asymmetric pathology. (cdc.gov)

The basal complexes, which will segregate to the GMC, asymmetrically localize three major cell fate determinants: Prospero, Brat, and Numb, which inhibit self-renewal and promote differentiation (Bowman et al. (stembook.org)
We furthermore identified epidermal insulin/insulin-like-growth-factor 1 (IGF-1) as major activators of Rac through which they determine asymmetric differentiation and proliferative potential of progenitors and thereby regulate epidermal differentiation and barrier function. (uib.no)
Authors show here that genomic deletion of the p38α mitogen activated protein kinase specifically in the B cell lineage leads to diminished plasma cell differentiation via impairment of a transcriptional regulatory program by BLIMP1. (nature.com)
Lung branching requires differentiation of progenitor cells to be coordinated with morphogenetic events. (nature.com)
Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)
Cell fate decisions within these hierarchical brain cell lineages are tightly controlled and irreversible: e.g. cells in the state of differentiation will not turn into progenitor cells or stem cells. (stanford.edu)
This is especially true for malignant glioma cells, which simultaneously express markers of different lineages and states exhibiting incomplete differentiation. (stanford.edu)
She also talked about how asymmetric cell division works as the basis of differentiation. (risingkashmir.com)
Firstly, GB cells show in vitro differentiation pattern similar to GFAP positive neural cells, rather than classical (GFAP negative) NSC. (hindawi.com)
This type of cell differentiation is achieved by asymmetrical segregation of cell fate determinants (see CELL POLARITY) and orientation of the MITOTIC SPINDLE in the context of intrinsic and extrinsic cues (STEM CELL NICHE). (bvsalud.org)
Huntingtin Regulates Mammary Stem Cell Division and Differentiation. (ens.fr)
Its inhibition in human ES cells results in enhanced spontaneous differentiation. (silverchair.com)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

The microtubules from the spindle nucleate from microtubule-organizing centers (MTOCs), specialized structures that localize at both spindle poles and that are known as centrosomes in higher eukaryotes or spindle pole bodies (SPBs) in yeast cells. (cam.ac.uk)
Centrosomes and SPBs play a particularly relevant role in cells that display an asymmetric division, since these structures can be used to facilitate the unequal distribution of molecules and organelles between the mother and daughter cells, thus contributing to the generation of two cells with a differential fate or proliferative capacity. (cam.ac.uk)
Centrosomes in asymmetric cell division and neocortical development. (mpg.de)
A GFP fusion with the mitotic kinase Aurora-A labels centrosomes during the division of an SOP cell. (oeaw.ac.at)
Shortly after division, they re-appear near the centrosomes in both daughter cells. (oeaw.ac.at)
In the absence of cki-2 , embryos have supernumerary centrosomes and form multipolar spindles that result in severe aneuploidy after anaphase of the first division. (rupress.org)

It is well established that the differential partitioning of cell fate determinants in the form of RNA and proteins between sibling cells induces changes in cell behavior and fate. (washington.edu)
In some cases, factors within the dividing mother cell lead to the differential segregation of cell fate determinants to give two distinct daughters upon division. (stembook.org)
1. Cell fate determinants are segregated to the basal cortex of the dividing NB, resulting in a disruption of the symmetry of the mother cell prior to division. (stembook.org)
2. The mitotic spindle is aligned along the apical-basal axis to ensure accurate segregation of these cell fate determinants to the appropriate daughter cell. (stembook.org)
however, some studies suggest that extrinsic signals from the overlying epithelium also facilitate proper spatio-temporal localization of cell fate determinants (Lee et al. (stembook.org)
These data indicate that embryonic NBs respond to signals from the adjacent epithelium to specify correct spindle orientation and localization of cortical cell fate determinants. (stembook.org)
Segregation of cell fate determinants to the daughter GMC is regulated by the reciprocal localization of four protein complexes: two complexes are localized to the apical cortex and two to the basal cortex (see Figure 1 ). (stembook.org)
You will use modern molecular biology techniques, including CRISPR/Cas9 gene editing, to manipulate putative molecular determinants of leukocyte cell mechanics. (sfu.ca)
Intercellular adhesion and cell polarity are crucial determinants of tissue morphogenesis and tissue architecture. (uib.no)
A high-magnification movie of a single dividing SOP cell highlights the dynamics of cell fate determinants during asymmetric cell division. (oeaw.ac.at)
The alignment of the mitotic spindle with this axis of polarity ensures that cell fate determinants are segregated into only one daughter cell. (oeaw.ac.at)
A GFP fusion with Partner-of-Numb (Pon) reveals the asymmetric segregation of cell fate determinants during the division of these cells. (oeaw.ac.at)
During two years as an instructor and head of a research group in Munich, Germany, Dr. Petritsch and her team showed that cell fate determinants use a bimodal mechanism (diffusion and active capturing) for proper intracellular location. (stanford.edu)

Studies of the underlying mechanisms regulating asymmetric division of Drosophila neuroblasts (NBs) have contributed to the establishment of paradigms and identification of molecular components that control asymmetric division in more complex stem cell systems (Reviewed in Chia et al. (stembook.org)
We addressed this question in Drosophila neural stem cells called neuroblasts. (uni-koeln.de)
Below is a collection of time-lapse videos illustrating the process of asymmetric cell division in Drosophila sensory organ precursor (SOP) cells. (oeaw.ac.at)
SOP cells are one of the best characterized model systems for asymmetric cell division as they generate the four different cell types constituting Drosophila external sensory organs in a stereotyped lineage. (oeaw.ac.at)
Drosophila neuroblasts: a model for stem cell biology. (oeaw.ac.at)
Using cell-restricted transcriptome analysis, here we show that the ommatidial cone cells (aka Semper cells) in the Drosophila compound eye are enriched for glial regulators and effectors, including signature characteristics of the vertebrate visual system. (plos.org)
Further, we find that specific factors critical for glial function in other species are also critical in cone cells to support Drosophila photoreceptor activity. (plos.org)
These data define genetically distinct glial signatures in cone/Semper cells that regulate their structural, functional and homeostatic interactions with photoreceptor neurons in the compound eye of Drosophila . (plos.org)
Here, using the genetic model Drosophila melanogaster , we identify a new glial cell type in one of the most active tissues in the nervous system-the retina. (plos.org)
Charlton-Perkins MA, Sendler ED, Buschbeck EK, Cook TA (2017) Multifunctional glial support by Semper cells in the Drosophila retina. (plos.org)
Drosophila melanogaster) are typically long-lived, lineage-restricted, clonogenic and quiescent cells with somatic descendants and tissue/organ-restricted activities. (bvsalud.org)

Asymmetric cell division: recent developments and their implications for tumour biology. (oeaw.ac.at)
Ho EK, Tsai AE, Stearns T., 2020, Transient primary cilia mediate robust Hedgehog pathway-dependent cell cycle control, Current Biology , 30(14):2829-2835.e5. (stanford.edu)
Dr Radha also laid emphasis on the fact that there are a lot of unsolved problems in biology and answers to many of those come from analysing cells. (risingkashmir.com)
Fluorescent proteins are powerful molecular biology tools that have been used to study the subcellular dynamics of proteins within live cells for well over a decade. (biomedcentral.com)
Nature Cell Biology. (elsevier.com)
The Journal of Cell Biology , 206(6):707-717. (ens.fr)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)

Similarly, many cell types also generate physical asymmetry in the form of sibling cell size differences. (washington.edu)
Emerging data suggests that spindle-induced cleavage furrow positioning through regulated spindle placement and spindle geometry is insufficient to explain all occurrence of cell-size asymmetry. (washington.edu)
Instead, asymmetric membrane extension based on asymmetric Myosin localization and cortical remodeling could be a driving force for the generation of physical asymmetry. (washington.edu)
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. (oeaw.ac.at)

The second chapter of this thesis focuses on what factors may drive the divergence of cell fates in asymmetric cell division of CD8+ T cells. (columbia.edu)
Asymmetric division is a property of stem cells that leads to the generation of two cells that can adopt different fates. (stembook.org)
In others, however, establishment of different fates is reinforced through signaling from neighboring cells. (stembook.org)
3 . Asymmetric positioning of the anaphase spindle results in daughter cells that will not only assume different fates but also differ in size. (stembook.org)
Defects in cell fate control could explain many key defects present in brain tumors Of special emphasis, we study the establishment of cell fates within normal hierarchical brain lineages for comparison to the dysregulated cell-fate hierarchies seen in brain tumors. (stanford.edu)
Asymmetric cell division (ACD) generates two daughter cells with different sizes, shapes, compositions, and fates. (biologists.com)

However, the molecular mechanisms underlying leukocyte cell mechanics are poorly understood. (sfu.ca)
Mechanisms of asymmetric stem cell division. (oeaw.ac.at)
Her research identified conserved mechanisms of cell fate determination in mammalian brain progenitors and led to a paradigm shift in understanding how brain progenitor cells self-renew and differentiate. (stanford.edu)
The mechanisms for cell fate decisions in the human brain are largely unknown. (stanford.edu)
By using patient-derived cells from brain surgeries, we investigate cell fate decision mechanisms in the normal brain and in brain malignancies. (stanford.edu)

The goal of this project is to determine the role of specific membrane and cytoskeleton components in leukocyte cell mechanics. (sfu.ca)
sec15 labels puncta (presumably vesicles), which gather beneath the apical cell membrane. (oeaw.ac.at)
To function, the PTEN enzyme attaches (binds) to another PTEN enzyme (dimerizes) then binds to the cell membrane. (medlineplus.gov)

The distribution of the duplicated genome during cell division is facilitated by the spindle, a remarkable and complex cellular machinery formed by a bipolar array of microtubules that guide the segregation of chromosomes. (cam.ac.uk)
Besides their function in chromosome segregation, spindle MTO Cs constitute critical platforms where multiple signaling pathways converge to regulate essential processes in the cell, such as the proper and timely regulation of mitosis, the coordination of cell cycle progression and cell metabolism or the functionality of the mitotic checkpoints. (cam.ac.uk)

Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation. (mysciencework.com)

She returned to UCSF to conduct translational research, and apply her combined expertise in stem cells and signaling on the study of brain neoplasms and human stem and progenitor cells. (stanford.edu)

In sea squirts, cells known as founder cells re-distribute proteins called FGF receptors during cell division so that only half of the daughter cells have FGF receptors. (swarthmore.edu)
Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
LamA recruits proteins involved in cell wall synthesis, and in this study, Rego and colleagues characterize the role of one of the interacting proteins, polar growth factor A (PgfA), in mycobacterial growth and division. (nature.com)

Asymmetric cell division (ACD) is a mechanism to generate cellular diversity and used by prokaryotes and eukaryotes alike. (washington.edu)
The ability of cells to divide asymmetrically to produce two different cell types provides the cellular diversity found in every multicellular organism. (stembook.org)
I will present recent research from our group that sheds new light on the role of MTO Cs as epicenters for the integration and coordination of key cellular processes during asymmetric cell division, as well as on their importance during the aging process and in the determination of a differential cellular fate. (cam.ac.uk)
To support this critical juncture in the young field of 'immunometabolism,' we are assembling international experts from academia and industry on the role of cellular metabolism in the programming of myeloid and lymphoid immune cells in immunity and disease. (grc.org)
We have created cellular and mouse models to elucidate how the GNAQ mutation affects EC function, how these alterations lead to CM, and how we can prevent the formation or growth of CM. Although the mutation is enriched in EC, our goal is to identify the breadth of cell types that carry the somatic GNAQ R183Q allele. (harvard.edu)
Cellular reprogramming, whether by cell fusion, somatic cell nuclear transfer or transcription factor transduction,also requires changes at the epigenetic level and thus, the first part of the conference focused on epigenetic regulators and reprogramming. (silverchair.com)
However, from any starting state, cells can change their stemness status, underscoring their dynamic cellular potencies. (bvsalud.org)
Transcriptome sequencing, cellular labeling, and proliferation in vivo essays revealed that CNS regeneration is mediated by a newly formed neural progeny and the activation of neurodevelopmental pathways that are associated with enhanced stem-cell activity. (bvsalud.org)

As sporulation initiates, cells undergo an asymmetric division leading to differential gene expression in the small prespore and large mother cell compartments. (biomedcentral.com)
Such ASCs are mostly rare, morphologically undifferentiated, and undergo asymmetric cell division. (bvsalud.org)

This analysis reveals complex interactions between satellite cells and both injured and uninjured fibers and provides in vivo evidence for the asymmetric division of satellite cells driving both self-renewal and regeneration via a clonally restricted progenitor pool. (bath.ac.uk)

As we review here, the experimental accessibility of these epidermal lineages, particularly in Arabidopsis , has made stomata a conceptual and technical framework for the study of cell fate, stem cells, and cell polarity in plants. (biologists.com)
Stem cells establish cortical polarity and divide asymmetrically to simultaneously maintain themselves and generate differentiating offspring cells. (uni-koeln.de)
Several chromatin modifiers have been identified as stemness factors in mammalian pluripotent stem cells, but whether these factors control stem cell polarity and asymmetric division has not been investigated so far. (uni-koeln.de)
Our findings reveal an evolutionarily conserved functional link between Myc, the Tip60 complex, and the molecular network controlling cell polarity and asymmetric cell division. (uni-koeln.de)
Cell division orientation is thought to result from a competition between cell geometry and polarity domains controlling the position of the mitotic spindle during mitosis. (elifesciences.org)
Depending on the level of cell shape anisotropy or the strength of the polarity domain, one dominates the other and determines the orientation of the spindle. (elifesciences.org)
Here, we show that cell geometry and polarity domains cooperate, rather than compete, in positioning the cleavage plane during UCDs in early ascidian embryos. (elifesciences.org)
We found that the UCDs and their orientation at the ascidian third cleavage rely on the spindle tilting in an anisotropic cell shape, and cortical polarity domains exerting different effects on spindle astral microtubules. (elifesciences.org)
By systematically varying mitotic cell shape, we could modulate the effect of attractive and repulsive polarity domains and consequently generate predicted daughter cell size asymmetries and position. (elifesciences.org)
We therefore propose that the spindle position during UCD is set by the combined activities of cell geometry and polarity domains, where cell geometry modulates the effect of cortical polarity domain(s). (elifesciences.org)
Their findings provide a new perspective on the roles of cell polarity and shape in the control of spindle positioning, and are of broad interest to cell and developmental biologists. (elifesciences.org)
During mitosis SOP cells break down and re-establish certain aspects of their apical-basal polarity, as illustrated by this 3D reconstruction of a dividing SOP cell expressing a GFP fusion with sec15, a component of the exocyst complex. (oeaw.ac.at)

2006 ). NBs are neural stem/progenitor cells that are specified during embryogenesis and divide to generate the larval neurons. (stembook.org)
Dr. Petritsch is an expert in oligodendrocyte progenitor cells, and cancer stem cells, and her team's emphasis is on intra-tumoral heterogeneity, in vitro and in vivo cancer model development, and tumor-immune interactions. (stanford.edu)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

Using cell-specific molecular genetic approaches, we demonstrate that cone cells (CCs) also share molecular, functional, and genetic features with both vertebrate and invertebrate glia to prevent light-induced retinal degeneration and provide structural and physiological support for photoreceptors. (plos.org)
However, the molecular details of asymmetric polar growth are not completely understood. (nature.com)

Cell Biol. (washington.edu)
Curr Opin Cell Biol. (nih.gov)
Nat Rev Mol Cell Biol 11, 849-860. (oeaw.ac.at)
J Cell Biol (2006) 174 (6): 751-757. (rupress.org)

A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2. (nih.gov)
In addition, cone cell-targeted gene knockdowns demonstrate that such glia-associated factors are required to support the structural and functional integrity of neighboring photoreceptors. (plos.org)
a beta-cell-specific transcriptional enhancer found in the insulin gene. (embl.de)
Gene expression is controlled temporally by a subset of sigma factors in both the developing spore and mother cell. (biomedcentral.com)
Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC). (cdc.gov)
We combined targeted DNA- and genome-wide RNA-sequencing to identify genetic variants and gene expression signatures respectively from patients with HNSCC including oropharyngeal squamous cell carcinomas (OPSCC). (cdc.gov)
In 2005, researchers discovered a mutation in the Janus Tyrosine Kinase 2 gene (JAK2 (V617F)), which plays a pivotal role in the regulation of blood cell production (Levine et al. (cdc.gov)
Cell movements at Hensen's node establish left/right asymmetric gene expression in the chick. (medscape.com)

On admission, the patient's white blood cell count was 8000/mm3 (4,300-10,800/mm3) with a differential of 46 neutrophils, 47 bands, 3 lymphocytes, and 4 monocytes. (cdc.gov)

Although cell shape often predicts spindle orientation, there are numerous examples where this is not the case in somatic cells ( Finegan and Bergstralh, 2019 ). (elifesciences.org)

Multicellular organisms are made up of a variety of different types of cells that perform different functions. (swarthmore.edu)

2006). NBs that are still in contact with epithelial cells as they divide always produce GMCs opposite the site of epithelial-NB contact. (stembook.org)
The area in between SOP cells is taken up by epithelial cells, which do not express any fluorescent marker. (oeaw.ac.at)
Wells KL , Miller CN, Gschwind AR, Wei W, Phipps JD, Anderson MS and Steinmetz LM, 2020, Combined transient ablation and single-cell RNA- sequencing reveals the development of medullary thymic epithelial cells . (stanford.edu)

In the healthy brain, neuroglia stem cells generate progenitors, which in turn give rise to differentiating cells that will eventually acquire their final functional state. (stanford.edu)
GB cells in primary cultures become senescent in vitro , similar to GFAP positive neural progenitors, whereas classical NSC proliferate in vitro infinitely. (hindawi.com)
Considering the above-mentioned and other discussed in articles data, we suggest that GFAP positive cells (astrocytes, radial glia, or GFAP positive neural progenitors) are more likely to be source of GB than classical GFAP negative NSC, and further in vitro assays should be focused on these cells. (hindawi.com)
However, there is a dispute whether radial glial cells are stem cells or progenitors. (hindawi.com)

A GFP fusion with Spaghetti squash (Sqh), a regulatory light chain of non-muscle myosin-II, reveals cortical dynamics during cell division. (oeaw.ac.at)
Here, myosin-II and actin form a contractile ring, which powers the physical separation of the daughter cells. (oeaw.ac.at)
Her postdoctoral studies on neural stem cells and asymmetric cell division in the Lab of Dr. Yuh Nung Jan at the Howard Hughes Medical Institute and University of San Francisco, California implied for the first time a minus-end directed myosin in the process of cell fate determination. (stanford.edu)

GFP is recruited into patches all around the cell cortex until, from prometaphase onwards, its cortical distribution becomes uniform. (oeaw.ac.at)
A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cells. (ens.fr)
Organoids from human pluripotent cells can be used to model cerebral cortical development. (jcbose.ac.in)

abstract = "Skeletal muscle is an example of a tissue that deploys a self-renewing stem cell, the satellite cell, to effect regeneration. (bath.ac.uk)

In the embryo, NBs divide perpendicular to the plane of the neuroepithelium to generate another (apical) NB and a smaller, basally located ganglion mother cell (GMC) that will differentiate into neurons or glia. (stembook.org)
that is, they have the ability to generate other stem cells and perpetuate themselves. (bvsalud.org)

Developmental cell programs are co-opted in inflammatory skin disease. (ncl.ac.uk)
Developmental models distill essential problems faced by cells, tissues and organisms into simplified and experimentally accessible systems. (biologists.com)
Developmental Cell , 21(1):102-19. (ens.fr)
Terms for developmental and adult lung structures, tissues, and cells were included, providing comprehensive ontologies for application at varying levels of resolution. (biomedcentral.com)

We define a zebrafish muscle stem cell population analogous to the mammalian satellite cell and image the entire process of muscle regeneration from injury to fiber replacement in vivo. (bath.ac.uk)
Stress-induced amyloid aggregation in mammalian cells. (sfu.ca)
Specialized innate immune cells, like macrophages, have the ability to engulf and kill microbes and mammalian cells alike trough phagocytosis. (sfu.ca)
The concept of the stem cell niche was initially proposed by Schofield in the context of the mammalian blood system( Schofield, 1978 ). (silverchair.com)

Glial cells play structural and functional roles central to the formation, activity and integrity of neurons throughout the nervous system. (plos.org)
Accessory and support glial cells also exist in invertebrates, but which cells play this function in the insect retina is largely undefined. (plos.org)
3 ]. Authors suggest that GB originates from radial glial cells, more specifically, outer radial glial cells (oRG). (hindawi.com)
At least in vitro radial glial cells usually do not meet the criteria of stem cell definition because their proliferation potential is very limited. (hindawi.com)
however, in other articles radial glial cells were recognized as cells with limited in vitro and even in vivo proliferation potential [ 4 - 7 ]. (hindawi.com)
Probably the loss of division capacity shown by radial glial cells in vitro has something to do with radial glia transition to astrocytes observed during final stages of CNS development [ 40 ]. (hindawi.com)

Detection and tracking of overlapping cell nuclei for large scale mitosis analyses. (ens.fr)
I shall discuss about our very recent findings of wobbling motion in 183Au nucleus, which is a common phenomenon for an asymmetric top in the classical world but an extremely rare one in atomic nuclei. (jcbose.ac.in)

We demonstrate unequal expression of transcription factor TCF1 between cytokinetic sibling cells, which may be driven by unequal transduction of nutrient-sensitive PI3K/AKT/mTOR signaling. (columbia.edu)
This finding suggests that receptor breakdown plays a role in promoting unequal distribution early in division, while receptor recycling promotes unequal distribution later in division. (swarthmore.edu)
Whether and how such competition is also at work to determine unequal cell division (UCD), producing daughter cells of different size, remains unclear. (elifesciences.org)
Unequal cell division that results in daughter cells of different sizes. (bvsalud.org)

It is highly possible that several populations of tumor initiating cells (TIC) exist within GB, adjusting their phenotype and even genotype to various environmental conditions including applied therapy and periodically going through different TIC states as well as non-TIC state. (hindawi.com)

All patients had acute onset of lance conducted by the Mississippi Department of Health asymmetric weakness and areflexia but no sensory abnor- and the Louisiana Office of Public Health. (cdc.gov)
Clinicians should be prepared to recognize cases presenting in the late summer and fall, often following a viral respiratory infection, and presenting with asymmetric flaccid weakness that progresses over hours to days, associated with characteristic MRI and CSF findings," the authors write. (medscape.com)

Mechanical properties of immune cells play important roles in multiple contexts: phagocytosis, immunological synapse formation, cell migration, cancer proliferation. (sfu.ca)
We also demonstrate that expression of LBD16-SRDX, a dominant repressor of LBD16/ASL18 and its related LBD/ASLs, does not interfere in the specification of LR founder cells with local activation of the auxin response, but it blocks the polar nuclear migration in LR founder cells before ACD, thereby blocking the subsequent LR initiation. (biologists.com)
Evidence suggests that this enzyme also helps control cell movement (migration), the sticking (adhesion) of cells to surrounding tissues, and the formation of new blood vessels (angiogenesis). (medlineplus.gov)

Knockdown of inhibitor of growth protein 2 inhibits cell invasion and enhances chemosensitivity to 5-FU in human gastric cancer cells. (nih.gov)
The receptor-interacting protein (RIPK1) promotes cell death and contributes to nonalcoholic steatohepatitis pathogenesis. (nature.com)
a protein required for the asymmetric division of vulval blast cells. (embl.de)
An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria. (nature.com)

In Arabidopsis thaliana , two AUXIN RESPONSE FACTORs (ARFs), ARF7 and ARF19, positively regulate LR formation through activation of the plant-specific transcriptional regulators LATERAL ORGAN BOUNDARIES-DOMAIN 16/ASYMMETRIC LEAVES2-LIKE 18 ( LBD16/ASL18 ) and the other related LBD/ASL genes. (biologists.com)
These results were confirmed by transcriptomic analyses that highlighted the specific genes involved in these cell death pathways. (bvsalud.org)
Moreover, the presence of tubulovesicular structures in the brain medulla alongside the over-expression of prion disease genes in late cycle suggested a cell-to-cell, prion-like propagation recalling the conformational disorders typical of some human neurodegenerative diseases. (bvsalud.org)

The enzyme acts as a tumor suppressor, which means that it helps regulate cell division by keeping cells from growing and dividing (proliferating) too rapidly or in an uncontrolled way. (medlineplus.gov)

The polarization of distinct scaffold-signaling hubs at opposite cell poles constitutes the basis of asymmetric cell division. (nature.com)
Distinct features of Mycobacterium tuberculosis are a complex cell envelope and that they grow by inserting new cell wall material at their poles, which gives rise to an asymmetric growth pattern and a phenotypically heterogeneous cell population. (nature.com)

During vegetative growth, the division septum is formed at the midcell to produce two equal daughter cells. (mysciencework.com)
The main research interest of my laboratory is to understand how the establishment, maintenance and restoration of cell and tissue architecture are coordinated with the growth, metabolism and innate immunity status of cells to drive morphogenesis and to maintain tissue homeostasis. (uib.no)
ASCs may constitute up to 40% of animal cells, and participate in a range of biological phenomena, from whole-body regeneration, dormancy, and agametic asexual reproduction, to indeterminate growth. (bvsalud.org)
All of these genetic changes prevent the PTEN enzyme from regulating cell proliferation effectively, which can lead to uncontrolled cell growth and the formation of hamartomas and other types of tumors. (medlineplus.gov)
This uncontrolled cell growth contributes to the formation of a cancerous tumor. (medlineplus.gov)
LamA, a member of the divisome, has been implicated to have a crucial role in asymmetric polar growth. (nature.com)

One has the potential to renew stem cell identity and continue to divide in an asymmetric manner, whereas the other cell will differentiate along a specific lineage. (stembook.org)
Stomata (the epidermal valves that mediate gas exchange between plants and the atmosphere) and the lineage from which they are derived have emerged as a pre-eminent model for answering questions about cell fate and pattern in plants. (biologists.com)
Multiplex cell and lineage tracking with combinatorial labels. (ens.fr)
Regardless of the particular lineage pathway involved, differentiated human ES cells downregulate sirtuin 1, a histone deacetylase. (silverchair.com)
In cell lineage-tracing studies, Thomas Graf [The Centre for Genomic Regulation (CRG), Barcelona, Spain] asked how `instructive' transcription factors drive lineage choice in blood cells. (silverchair.com)

Prof Vegesna Radha, the invited speaker, discussed the adoption of tissue specific functions by cells in detail and explained how the sizes and shapes of tissues are determined. (risingkashmir.com)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
As a result, approximately 300 terms for fetal and postnatal lung structures, tissues, and cells were identified for each species. (biomedcentral.com)

All of these functions help prevent uncontrolled cell proliferation that can lead to the formation of tumors. (medlineplus.gov)

Human papilloma virus (HPV) causes a subset of head and neck squamous cell carcinomas (HNSCC) of the oropharynx. (cdc.gov)

We demonstrate asymmetric Foxp3 expression between cytokinetic sibling cells found in the thymus as well as from an in vitro Treg induction model. (columbia.edu)
We also show that in vitro upregulation of Foxp3, the major Treg-associated transcription factor, is inhibited by cell cycle inhibitors, further linking the act of cell fate divergence to a divisional event. (columbia.edu)
On the other hand, in vitro division limits do not necessarily mean that radial glia are not stem cells. (hindawi.com)
One would suggest that we are not able to culture these cells properly in vitro and hiding their ability to self-renew in these conditions (Table 1 ). (hindawi.com)

In chapter three, we extend our interrogation of asymmetric cell division in lymphocytes to the development of regulatory T cells, which are important for the maintenance of immunological self-tolerance. (columbia.edu)
A cell atlas of human thymic development defines T cell repertoire formation. (ncl.ac.uk)
Glia have been recognized as a major and heterogeneous non-neuronal cell type in the nervous system for more than 150 years, but their chief homeostatic and regulatory roles in nervous system development and maintenance have only recently emerged [ 1 - 4 ]. (plos.org)
Proper cell fate decisions by neuroglia stem cells are critical for growing the cell lineages that form the brain during development and to maintain adult brain homeostasis. (stanford.edu)
Sirtuins might therefore be of therapeutic significance, as they are overexpressed in cancer cells, and sirtuin inhibitors inhibit the development of thymic lymphomas in murine models. (silverchair.com)
The altered enzyme is unable to restrain cell division or signal abnormal cells to die, which contributes to the development of hamartomas and cancerous tumors. (medlineplus.gov)
The nodal signaling pathway controls left-right asymmetric development in amphioxus. (medscape.com)

Stem cells in particular rely on ACD to self-renew the stem cell while simultaneously generating a differentiating sibling. (washington.edu)
It has been demonstrated in B cells and T cells that the generation of these cell types may be accomplished simultaneously through asymmetric cell division. (columbia.edu)

As the cell enters mitosis, however, it is increasingly recruited to the cell cortex. (oeaw.ac.at)

The immune system relies on the collaboration of heterogeneous cell types to respond to infection, develop immunological memory, and to maintain immunological tolerance. (columbia.edu)

Anatomy18

Organisms11

Diseases1

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes31

Information Science3

Immortalized, pre-malignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA. (1/72)

JMY is required for asymmetric division and cytokinesis in mouse oocytes. (2/72)

Isolation of live label-retaining cells and cells undergoing asymmetric cell division via nonrandom chromosomal cosegregation from human cancers. (3/72)

Chasing the immortal strand: evidence for nature's way of protecting the breast genome. (4/72)

The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization. (5/72)

Fly meets yeast: checking the correct orientation of cell division. (6/72)

Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts. (7/72)

Molecular profiling of stomatal meristemoids reveals new component of asymmetric cell division and commonalities among stem cell populations in Arabidopsis. (8/72)

Asymmetric Cell Division

Cell Division

Juvenile Hormones

Cell Polarity

Spindle Apparatus

Caenorhabditis elegans Proteins

Caenorhabditis elegans

Drosophila Proteins

Cell Lineage

Miosis

Drosophila

Sense Organs

Stem Cells

Mitosis

Plant Stomata

Embryo, Nonmammalian

Receptors, Notch

Nuclear Matrix-Associated Proteins

Centrosome

Cell Cycle Proteins

Mutation

Cell Differentiation

Models, Biological

Drosophila melanogaster

Gene Expression Regulation, Developmental

Cytoskeletal Proteins

Body Patterning

Guanine Nucleotide Dissociation Inhibitors

Animals, Genetically Modified

Helminth Proteins

Signal Transduction

Cell Cycle

Molecular Sequence Data

Nervous System

Transcription Factors

Genes, Helminth

Caulobacter crescentus

Arabidopsis

Amino Acid Sequence

Neurons

Membrane Proteins

Microtubules

Neuropeptides

Plant Roots

Green Fluorescent Proteins

Arabidopsis Proteins

Frizzled Receptors

Zygote

Phenotype

Chromosome Segregation

Microscopy, Fluorescence

Nerve Tissue Proteins

Wnt Proteins

Carrier Proteins

GTP-Binding Protein alpha Subunits

Insect Proteins

Bacterial Proteins

Protein Transport

Dyneins

Larva

Sequence Homology, Amino Acid

Nuclear Proteins

Meiosis

RNA Interference

Luminescent Proteins

Homeodomain Proteins

Recombinant Fusion Proteins

Spores, Bacterial

Protein Binding

Base Sequence

Gene Expression Regulation, Plant

Two-Hybrid System Techniques

Plant Proteins

Embryonic Development

Intracellular Signaling Peptides and Proteins

Bacillus subtilis

Cloning, Molecular

Neuroglia

DNA-Binding Proteins

Cell Nucleus