AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth CareGeographicals
AspirinAsthmaAnti-Asthmatic AgentsPlatelet Aggregation InhibitorsAnti-Inflammatory Agents, Non-SteroidalAsthma, Exercise-InducedAdministration, InhalationPeak Expiratory Flow RateAsthma, OccupationalForced Expiratory VolumeBronchial HyperreactivityBronchodilator AgentsRespiratory SoundsAllergensAdrenal Cortex HormonesTiclopidineThromboxane B2HypersensitivityAsthma, Aspirin-InducedCyclooxygenase InhibitorsPlatelet AggregationHypersensitivity, ImmediateRhinitisDrug Therapy, CombinationSalicylatesRespiratory Function TestsAlbuterolMethacholine ChloridePlatelet Function TestsRisk FactorsRhinitis, Allergic, PerennialDouble-Blind MethodSpirometryEosinophilsBronchiBudesonideSeverity of Illness IndexBeclomethasoneLeukotriene AntagonistsPrevalenceSkin TestsNebulizers and VaporizersLungTreatment OutcomeQuestionnairesBlood PlateletsSodium SalicylateStatus AsthmaticusBronchoconstrictor AgentsAirway RemodelingProspective StudiesDose-Response Relationship, DrugBronchoconstrictionBronchitisFibrinolytic AgentsAdrenergic beta-AgonistsRespiratory HypersensitivityAnti-Inflammatory AgentsOvalbuminTime FactorsHemorrhagePyroglyphidaeAnticoagulantsWarfarinTablets, Enteric-CoatedCase-Control StudiesCyclooxygenase 1Cohort StudiesFollow-Up StudiesPulmonary MedicineVital CapacityGlucocorticoidsProstaglandin-Endoperoxide SynthasesPlatelet ActivationThromboxanesBleeding TimeGastrointestinal HemorrhageSputumBronchoalveolar Lavage FluidCross-Sectional StudiesCoughExhalationIbuprofenAcetaminophenThromboxane A2Airway ObstructionDrug ResistanceAir Pollution, IndoorOccupational DiseasesEosinophiliaDrug HypersensitivityMitesOdds RatioEnvironmental ExposureLipoxinsThrombosisCromolyn SodiumAir PollutantsCyclooxygenase 2 InhibitorsPractice Guidelines as Topic
Aspirin
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Anti-Asthmatic Agents
Drugs that are used to treat asthma.
Platelet Aggregation Inhibitors
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Asthma, Exercise-Induced
Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
Administration, Inhalation
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Peak Expiratory Flow Rate
Measurement of the maximum rate of airflow attained during a FORCED VITAL CAPACITY determination. Common abbreviations are PEFR and PFR.
Asthma, Occupational
Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE.
Forced Expiratory Volume
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Bronchial Hyperreactivity
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
Bronchodilator Agents
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Respiratory Sounds
Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.
Allergens
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Adrenal Cortex Hormones
Ticlopidine
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
Thromboxane B2
A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin).
Hypersensitivity
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Asthma, Aspirin-Induced
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use.
Cyclooxygenase Inhibitors
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
Platelet Aggregation
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
Hypersensitivity, Immediate
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
Rhinitis
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
Drug Therapy, Combination
Therapy with two or more separate preparations given for a combined effect.
Salicylates
The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
Respiratory Function Tests
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Albuterol
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
Methacholine Chloride
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Platelet Function Tests
Laboratory examination used to monitor and evaluate platelet function in a patient's blood.
Risk Factors
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Rhinitis, Allergic, Perennial
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Spirometry
Measurement of volume of air inhaled or exhaled by the lung.
Eosinophils
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Bronchi
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
Budesonide
A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.
Severity of Illness Index
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Beclomethasone
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.
Leukotriene Antagonists
A class of drugs designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
Prevalence
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Skin Tests
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
Nebulizers and Vaporizers
Devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments.
Lung
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Questionnaires
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Blood Platelets
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
Sodium Salicylate
A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)
Status Asthmaticus
A sudden intense and continuous aggravation of a state of asthma, marked by dyspnea to the point of exhaustion and collapse and not responding to the usual therapeutic efforts.
Bronchoconstrictor Agents
Agents causing the narrowing of the lumen of a bronchus or bronchiole.
Airway Remodeling
The structural changes in the number, mass, size and/or composition of the airway tissues.
Prospective Studies
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Bronchoconstriction
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.
Bronchitis
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.
Fibrinolytic Agents
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
Adrenergic beta-Agonists
Drugs that selectively bind to and activate beta-adrenergic receptors.
Respiratory Hypersensitivity
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Anti-Inflammatory Agents
Substances that reduce or suppress INFLAMMATION.
Ovalbumin
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Hemorrhage
Bleeding or escape of blood from a vessel.
Pyroglyphidae
Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.
Anticoagulants
Agents that prevent clotting.
Warfarin
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Tablets, Enteric-Coated
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Cyclooxygenase 1
A constitutively-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes.
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Follow-Up Studies
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Pulmonary Medicine
A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.
Vital Capacity
The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Prostaglandin-Endoperoxide Synthases
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
Platelet Activation
A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
Thromboxanes
Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase.
Bleeding Time
Duration of blood flow after skin puncture. This test is used as a measure of capillary and platelet function.
Gastrointestinal Hemorrhage
Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Sputum
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
Bronchoalveolar Lavage Fluid
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Cross-Sectional Studies
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Cough
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Exhalation
The act of BREATHING out.
Ibuprofen
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.
Acetaminophen
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
Thromboxane A2
An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
Airway Obstruction
Any hindrance to the passage of air into and out of the lungs.
Drug Resistance
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Air Pollution, Indoor
The contamination of indoor air.
Occupational Diseases
Diseases caused by factors involved in one's employment.
Eosinophilia
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
Drug Hypersensitivity
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
Mites
Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.
Odds Ratio
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Environmental Exposure
The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.
Lipoxins
Trihydroxy derivatives of eicosanoic acids. They are primarily derived from arachidonic acid, however eicosapentaenoic acid derivatives also exist. Many of them are naturally occurring mediators of immune regulation.
Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel.
Cromolyn Sodium
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
Air Pollutants
Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.
Cyclooxygenase 2 Inhibitors
A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.
Practice Guidelines as Topic
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
Breath Tests
Any tests done on exhaled air.
Nedocromil
A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.
Dipyridamole
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Drug Administration Schedule
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Hospitalization
The confinement of a patient in a hospital.
Incidence
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Self Care
Performance of activities or tasks traditionally performed by professional health care providers. The concept includes care of oneself or one's family and friends.
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Acute Disease
Disease having a short and relatively severe course.
Airway Resistance
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
Androstadienes
Derivatives of the steroid androstane having two double bonds at any site in any of the rings.
Metered Dose Inhalers
A small aerosol canister used to release a calibrated amount of medication for inhalation.
Indomethacin
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Randomized Controlled Trials as Topic
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Patient Education as Topic
The teaching or training of patients concerning their own health needs.
Interleukin-13
A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.
Logistic Models
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
United States
Respiratory System
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
Th2 Cells
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
Risk Assessment
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Quality of Life
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Nitrogen Dioxide
Nitrogen oxide (NO2). A highly poisonous gas. Exposure produces inflammation of lungs that may only cause slight pain or pass unnoticed, but resulting edema several days later may cause death. (From Merck, 11th ed) It is a major atmospheric pollutant that is able to absorb UV light that does not reach the earth's surface.
Myocardial Infarction
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Ethanolamines
AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.
Smoking
Inhaling and exhaling the smoke of burning TOBACCO.
Tobacco Smoke Pollution
Contamination of the air by tobacco smoke.
Emergency Service, Hospital
Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.
Picornaviridae Infections
Virus diseases caused by the PICORNAVIRIDAE.
Cyclooxygenase 2
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
Primary Prevention
Specific practices for the prevention of disease or mental disorders in susceptible individuals or populations. These include HEALTH PROMOTION, including mental health; protective procedures, such as COMMUNICABLE DISEASE CONTROL; and monitoring and regulation of ENVIRONMENTAL POLLUTANTS. Primary prevention is to be distinguished from SECONDARY PREVENTION and TERTIARY PREVENTION.
Cockroaches
Insects of the order Dictyoptera comprising several families including Blaberidae, BLATTELLIDAE, Blattidae (containing the American cockroach PERIPLANETA americana), Cryptocercidae, and Polyphagidae.
Sulfinpyrazone
A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
Prostaglandins
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
Gastric Mucosa
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Toluene 2,4-Diisocyanate
Skin irritant and allergen used in the manufacture of polyurethane foams and other elastomers.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Patient Compliance
Voluntary cooperation of the patient in following a prescribed regimen.
Reye Syndrome
A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.
Puerto Rico
An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Aerosols
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Adrenergic beta-2 Receptor Agonists
Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS.
Administration, Oral
The giving of drugs, chemicals, or other substances by mouth.
Sinusitis
Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.
Desensitization, Immunologic
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Pregnenediones
Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures.
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Bronchial Spasm
Spasmodic contraction of the smooth muscle of the bronchi.
Urban Population
The inhabitants of a city or town, including metropolitan areas and suburban areas.
Dinoprostone
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
Eosinophil Cationic Protein
One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic protein is a 21-kDa cytotoxic peptide with a pI of 10.9. Although eosinophil cationic protein is considered a member of the RNAse A superfamily of proteins, it has only limited RNAse activity.
Recurrence
The return of a sign, symptom, or disease after a remission.
Occupational Exposure
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Naproxen
An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
Dermatitis, Atopic
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
Risk
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Anti-Allergic Agents
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)

Effect of in vitro aspirin stimulation on basophils in patients with aspirin-exacerbated respiratory disease. (1/27)

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Update on recent advances in the management of aspirin exacerbated respiratory disease. (2/27)

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Diagnosis of aspirin-induced asthma combining the bronchial and the oral challenge tests: a pilot study. (3/27)

BACKGROUND: We investigated the usefulness of the bronchial challenge (BC) with lysine-acetylsalicylate (L-ASA) in the diagnosis of aspirin-exacerbated respiratory disease (AERD) using a protocol that combined both the oral challenge (OC) and the BC tests. METHODS: Adult asthmatic patients with suspected AERD who underwent BC with L-ASA were included in the study. If the BC result with L-ASA was negative, an OC was carried out to establish the diagnosis. AERD was ruled out if both the BC and the OC results were negative (nonresponders). Both responders and nonresponders were compared for age, gender, a personal or family history of atopy, underlying disease, current asthma treatment, and presence of nasal polyps. Six patients with asthma but no suggestive history of AERD were included as controls. RESULTS: Twenty-two patients completed the study. Ten patients tested positive to the BC and/or OC (responders), whereas 12 did not (nonresponders). Seven out of the 10 responders had a positive BC result and 3 a positive OC result. After BC, 4 patients had an early asthmatic response, 1 had a dual response, and 2 had isolated late responses. No significant differences were observed in the aforementioned variables between responders and nonresponders. The results of both challenges were negative in the 6 controls. CONCLUSIONS: The BC had a high positive predictive value, was safe, and when negative, the subsequent OC did not result in any severe adverse reactions. The BC elicited an isolated late asthmatic response that has not been previously described in the literature.  (+info)

Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. (4/27)

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Airway responsiveness to inhaled aspirin is influenced by airway hyperresponsiveness in asthmatic patients. (5/27)

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Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population. (6/27)

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Increase in salivary cysteinyl-leukotriene concentration in patients with aspirin-intolerant asthma. (7/27)

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Nuclear translocation of the glucocorticoid receptor in fibroblasts of asthmatic patients with nasal polyposis insensitive to glucocorticoid treatment. (8/27)

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Aspirin-Exacerbated Respiratory Disease Defined | AAAAIAspirin-Exacerbated Respiratory Disease Defined | AAAAI
Aspirin-exacerbated respiratory disease (AERD), also known as Samters Triad, is a chronic condition consisting of asthma, sinus disease with recurrent nasal polyps, and sensitivity to aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs).
https://www.aaaai.org/conditions-and-treatments/conditions-dictionary/aerd
Aspirin desensitization in aspirin-exacerbated respiratory disease: New insights into the molecular mechanisms. - PubMed - NCBIAspirin desensitization in aspirin-exacerbated respiratory disease: New insights into the molecular mechanisms. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/30261990
994] Salicylates: Aspirin-induced asthma and nasal polyps (March 2011) - Food Intolerance Network994] Salicylates: Aspirin-induced asthma and nasal polyps (March 2011) - Food Intolerance Network
I have Samters Syndrome (consisting of asthma, aspirin sensitivity and nasal polyps) also known as Samters Triad or aspirin-induced asthma. For the last 29 years I have been taking medications and trying to stay alive. When I found the Australian
https://fedup.com.au/stories/2011/994-salicylates-aspirin-induced-asthma-and-nasal-polyps-march-2011
Aspirin-induced asthma: advances in pathogenesis and managementAspirin-induced asthma: advances in pathogenesis and management
In some patients with asthma, aspirin (ASA) and all nonsteroidal anti-inflammatory drugs that inhibit cyclooxygenase enzymes (cyclooxygenase-1 and -2) precipitate asthmatic attacks and naso-ocular reactions. This distinct clinical syndrome, called aspirin-induced asthma (AIA), is characterized by a …
https://pubmed.ncbi.nlm.nih.gov/10400832/?dopt=Abstract
Tobacco smoke and AERD / Samters Triad - Aspirin Exacerbated Respiratory DiseaseTobacco smoke and AERD / Samters Triad - Aspirin Exacerbated Respiratory Disease
Smoking, environmental tobacco smoke, and aspirin-exacerbated respiratory disease. A study published in 2012 by a group of researchers at the Scripps Clinic in California found that childhood exposure to environmental tobacco smoke was associated with increased odds of developing AERD, and the effec...
https://aerd.partners.org/tobacco-smoke-and-aerd-samters-triad/
6:07 pm6:07 pm
International Forum of Allergy & Rhinology. 2016. April; 6(4): 385-91. 30 patients diagnosed with aspirin sensitivity and aspirin-exacerbated respiratory disease (AERD) were entered into a diet trial. They ate either a regular diet or a low-salicylate diet for 6 weeks, and then ate the opposite one for another 6 weeks.. The patients were assigned their diet order randomly, and the physician evaluating them did not know which diet they were on at their evaluations. They were evaluated before beginning the study, after the first 6 weeks, and again at the end (12th week). The evaluations consisted of questionnaires including one named the SNOT-22 * and two others with the more boring names NSSS and ACQ-7, as well as measurements using instruments to evaluate their breathing and sinus condition.. * SNOT = Sino-Nasal Outcome Test. According to all the measurements, the patients had significant improvement on the low-salicylate diet.. QUOTE: The study further reinforces that a low-salicylate diet can ...
http://www.talkingaboutthescience.com/sommer2016/
Potential association of DCBLD2 polymorphisms with fall rates of FEV(1) by aspirin provocation in Korean asthmatics | Read by...Potential association of DCBLD2 polymorphisms with fall rates of FEV(1) by aspirin provocation in Korean asthmatics | Read by...
Aspirin exacerbated respiratory disease (AERD) is a clinical syndrome characterized by chronic rhinosinusitis with nasal polyposis and aspirin hypersensitivity. The aspirin-induced bronchospasm is mediated by mast cell and eosinophilic inflammation. Recently, it has been reported that the expression of discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) is up-regulated in lung cancers and is regulated by transcription factor AP-2 alpha (TFAP2A), a component of activator protein-2 (AP-2) that is known to regulate IL-8 production in human lung fibroblasts and epithelial cells. To investigate the associations between AERD and DCBLD2 polymorphisms, 12 common variants were genotyped in 163 AERD subjects and 429 aspirin tolerant asthma (ATA) controls. Among these variants, seven SNPs (rs1371687, rs7615856, rs828621, rs828618, rs828616, rs1062196, and rs8833) and one haplotype (DCBLD2-ht1) show associations with susceptibility to AERD. In further analysis, this study reveals significant ...
https://read.qxmd.com/read/22468095/potential-association-of-dcbld2-polymorphisms-with-fall-rates-of-fev-1-by-aspirin-provocation-in-korean-asthmatics
EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivityEAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type. The two frequent clinical presentations of aspirin hypersensitivity are: aspirin-induced bronchial asthma/rhinosinusitis (AIA …
https://pubmed.ncbi.nlm.nih.gov/17521312/?dopt=Abstract
Targeting Ca2+ release-activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for...
BACKGROUND: Nasal polyposis is a chronic inflammatory disease of the upper respiratory tract that affects around 2% of the population and almost 67% of patients with aspirin-intolerant asthma. Polyps are rich in mast cells and eosinophils, resulting in high levels of the proinflammatory cysteinyl leukotrienes. OBJECTIVES: To better understand the role of the proinflammatory leukotrienes in nasal polyposis, we asked the following questions: (1) How do nasal polyps produce leukotriene C(4) (LTC(4))? (2) Can LTC(4) feed back in a paracrine way to maintain mast cell activation? (3) Could a combination therapy targeting the elements of this feed-forward loop provide a novel therapy for allergic disease? METHODS: We have used immunohistochemistry, enzyme immunoassay, and cytoplasmic calcium ion (Ca(2+)) imaging to address these questions on cultured and acutely isolated human mast cells from patients with polyposis. RESULTS: Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels
https://www.neuroscience.ox.ac.uk/publications/106482
AIA Dezember 2017 - Aktuelle Informationen zum ArbeitsrechtAIA Dezember 2017 - Aktuelle Informationen zum Arbeitsrecht
Top Thema: Personalarbeit Rechtsprechungsänderung zur Verbindlichkeit einer unbilligen Weisung des Arbeitgebers Kündigungsrecht Unangemessene ...
https://www.osborneclarke.com/de/insights/aia-dezember-2017-aktuelle-informationen-zum-arbeitsrecht/
Eosinophil activation and novel mediators in the aspirin-induced nasal response in AERD | Read by QxMDEosinophil activation and novel mediators in the aspirin-induced nasal response in AERD | Read by QxMD
BACKGROUND: Eosinophil activation is the key feature of upper and lower airway inflammation in aspirin-exacerbated respiratory disease (AERD).. OBJECTIVE: To investigate the mechanism of eosinophil activation and identify novel inflammatory mediators using proteomics.. METHODS: Thirty-two asthmatic subjects were enrolled: 18 AERD patients who showed positive responses to the lysine-aspirin nasal provocation test (L-ASA NPT) and 14 aspirin-tolerant asthma (ATA) patients who showed negative responses to the L-ASA NPT (control group). Nasal lavage fluid (NLF) was collected before (baseline), at 10, 30 and 60 min (early response), and at 3 h (late response) after the L-ASA NPT. Eosinophil cationic protein (ECP) and cysteinyl leucotriene (CysLT) levels were measured using an ImmunoCAP system and ELISA respectively. To identify proteins involved in AERD, comparative proteomics was applied using NLFs collected before and after L-ASA NPTs in AERD patients. The clinical relevance of identified novel ...
https://read.qxmd.com/read/23786280/eosinophil-activation-and-novel-mediators-in-the-aspirin-induced-nasal-response-in-aerd
An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products | Science...An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products | Science...
Eicosanoids are key mediators of type-2 inflammation, e.g., in allergy and asthma. Helminth products have been suggested as remedies against inflammatory diseases, but their effects on eicosanoids are unknown. Here, we show that larval products of the helminth Heligmosomoides polygyrus bakeri (HpbE), known to modulate type-2 responses, trigger a broad anti-inflammatory eicosanoid shift by suppressing the 5-lipoxygenase pathway, but inducing the cyclooxygenase (COX) pathway. In human macrophages and granulocytes, the HpbE-driven induction of the COX pathway resulted in the production of anti-inflammatory mediators [e.g., prostaglandin E2 (PGE2) and IL-10] and suppressed chemotaxis. HpbE also abrogated the chemotaxis of granulocytes from patients suffering from aspirin-exacerbated respiratory disease (AERD), a severe type-2 inflammatory condition. Intranasal treatment with HpbE extract attenuated allergic airway inflammation in mice, and intranasal transfer of HpbE-conditioned macrophages led to ...
https://stm.sciencemag.org/content/12/540/eaay0605
Talk:Aspirin-induced asthma - WikipediaTalk:Aspirin-induced asthma - Wikipedia
Paracetamol is not an NSAID, as may be understood from the wording though paracetamol is generally considered safe - Preceding unsigned comment added by 88.90.68.85 (talk) 15:32, 21 September 2011 (UTC). The pathogenesis section is extremely confusing. In particular, the way the sentence describing differential PGE modulation I found difficult to understand. - Preceding unsigned comment added by 99.98.209.88 (talk) 14:09, 22 January 2013 (UTC). Has anybody else encountered this condition with the additional symptom of severe acute pain around diaphragm & back (possibly associated with gallbladder/spleen) and, later, likely autoimmune haemolytic anaemia? - Preceding unsigned comment added by 95.151.241.169 (talk) 19:52, 25 September 2013 (UTC). Also, interested in finding out more about the efficacy of aspirin desensitization for this condition. Does it reduce sensitivity to other allergens, such as ibuprofen & certain tree pollens (salicylate perhaps)? Does it really prevent or delay nasal ...
https://en.wikipedia.org/wiki/Talk:Aspirin-induced_asthma
Genetic polymorphisms in aspirin-intolerant chronic urticaria<...Genetic polymorphisms in aspirin-intolerant chronic urticaria<...
TY - JOUR. T1 - Genetic polymorphisms in aspirin-intolerant chronic urticaria. AU - Park, Hae Sim. AU - Kim, Seung Hyun. AU - Hur, Gyu Young. AU - Ye, Young Min. AU - Kim, Sangha. PY - 2007/9/1. Y1 - 2007/9/1. N2 - Background: Aspirin (acetylsalicylic acid, ASA)-intolerant urticaria with angioedema (AIU), a major type of aspirin-related hypersensitivity in urticaria, can be classified into two groups, acute ASA-intolerant urticaria (AIAU) and chronic ASA-intolerant urticaria (AICU), according to the duration of the urticaria. The pathogenic mechanism of AICU is not well understood. Methods/Data base: We present here a review of the recent findings from AICU molecular genetic studies. Results: A previous study on human leukocyte antigen (HLA) genotypes suggested that the HLA alleles DRB1*1302 and DQB1*0609 may be genetic markers for ASA-induced urticaria/angioedema for both AIAU and AICU, and that they were significantly associated with the prevalence of serum-specific immunoglobulin E (IgE) to ...
https://yonsei.pure.elsevier.com/en/publications/genetic-polymorphisms-in-aspirin-intolerant-chronic-urticaria
Suppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitro - pdf descargar
Suppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitro. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
http://libros.duhnnae.com/2017/jul8/15015395302-Suppression-of-nitric-oxide-production-from-nasal-fibroblasts-by-metabolized-clarithromycin-in-vitro.php
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Effect of rapid desensitization on platelet inhibition and basophil activation in patients with aspirin hypersensitivity and coronary disease Cases were patients with coronary artery disease (CAD) ... European Heart Journal - Cardiovascular Pharmacotherapy, Original Article, Stéphane Manzo-Silberman, Pascale Nicaise-Roland, Catherine Neukirch, Florence Tubach, Marie-Geneviève Huisse, Sylvie ... ...
https://semsearch.escardio.org/esc-en/search/theme/esc?fq%5B%5D=feed%3Aall&fq%5B%5D=otca_concept_Complex%3Acoronary+artery+disease&fq%5B%5D=otca_concept_Complex%3Aacute+coronary+syndromes&fq%5B%5D=author%3ASt%C3%83%C2%A9phane+Manzo-Silberman&fq%5B%5D=author%3ANadine+Ajzenberg&
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Banerjee, Probal and lyengar, Raghu R and Ayyer, Jayalekshmy and Bhattacharyya, PK (1984) Carbonation of Phenol: A Novel Reaction Involving Enzyme Model Catalysis. In: Current Science, 53 (23). pp. 1226-1228. Bhattacharyya, PK and Samanta, TB and Ullah, AHJ and Gunsalus, IC (1984) Chemical probes into the active centre of a heme thiolate monoxygenase. In: Journal of Chemical Sciences, 93 (8). pp. 1289-1304. Bhattacharyya, PK and Bhattacharyya, Apares (1981) Fluorescent labelling of strychnine: A novel approach for recognition of strychnine binding sites on neuronal membrane. In: Biochemical and Biophysical Research Communications, 101 (1). pp. 273-280. Ramanjaneyulu, R. and Madyastha, KM and Bhattacharyya, PK (1981) Chemical approach to aspirin hypersensitivity. In: Biochemical and Biophysical Research Communications, 101 (1). pp. 258-264. Bhattacharyya, Apares and Madyastha,, KM and Bhattacharyya, PK and Devanandan, MS (1981) Studies on bicuculline binding sites on neuronal membrane using ...
http://eprints.iisc.ernet.in/view/people/Bhattacharyya=3APK=3A=3A.html
FSIP2 - PrimePCR Assay and Template | Life Science | Bio-RadFSIP2 - PrimePCR Assay and Template | Life Science | Bio-Rad
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
https://www.bio-rad.com/en-us/prime-pcr-assays/gene/fsip2-cow
2020 COTE® Top Ten Awards - AIA2020 COTE® Top Ten Awards - AIA
The 2020 COTE® Top Ten program highlights projects that meet the AIA Committee on the Environments rigorous criteria for social, economic, and ecologic value.
https://www.aia.org/resources/6280238-2020-cote-top-ten-awards?editing=true
AIA Juni 2015 - Aktuelle Informationen zum ArbeitsrechtAIA Juni 2015 - Aktuelle Informationen zum Arbeitsrecht
In dieser Ausgabe finden Sie Beiträge zu folgenden Themen: Top Thema: Tarifeinheitsgesetz Der Bundestag hat das Gesetz zur Tarifeinheit besch...
https://www.osborneclarke.com/de/insights/aia-juni-2015-aktuelle-informationen-zum-arbeitsrecht/
Rhinology International Journal
METHODOLOGY: A prospective cohort study was performed. Patients with CRS received roxithromycin (150 mg) once daily for 12 weeks. Nasal secretions and serology were collected. Nine predictors for LDM response were assessed: nasal secretion IgE, nasal secretion IL-5, serum IgE, serum eosinophils, serum neutrophils, nasal polyps, asthma, allergy, and aspirin hypersensitivity, using receiver-operating curve analysis and multivariable logistic regression. Macrolide responders were those with sino-nasal outcome test-22 improvement, symptoms visual analogue scale decreased to ≤5, and no rescue medication ...
https://www.rhinologyjournal.com/buy_article.php?id=2763
Official AiA18 App | American Society on AgingOfficial AiA18 App | American Society on Aging
Download the free AiA18 app and use it to search the sessions, look up presenter information, find exhibitor locations and contacts, connect with the AiA18 community with in-app social tools, and more! ...
http://www.asaging.org/official-aia18-app
AIA Minneapolis Merit Award Event | AIA MinnesotaAIA Minneapolis Merit Award Event | AIA Minnesota
Register to attend the event below. Please add the first and last names of additional attendees in the Guest field on the next page ...
https://www.aia-mn.org/misc-event/aia-minneapolis-merit-award-event-amill/
Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal PolyposisSalicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis
Background: A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). Objective: To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. Methods: A cross sectional multicenter study was done in two tertiary centers for allergy in Iran. Adult patients with NP were selected for the study that had been referred to allergy clinics. The oral aspirin challenge (OAC) test was performed to identify aspirin exacerbated respiratory disease (AERD) and the OFC test was used to investigate food intolerance. Atopic evaluation was performed by skin-prick tests, nasal smear and blood eosinophil count as well as serum total IgE. Results: One hundred and nineteen Iranian patients (female to male ratio 1.05) with NP were enrolled (mean age, 38 ± 11 years). Recurrence of nasal polyposis was 64.7%. OAC was
http://iji.sums.ac.ir/article_39292.html
Clopidogrel post mi nice
Main / New Prescription / Clopidogrel post mi nice NICE have issued guidance as to the use of antiplatelet agents post myocardial infarction (1). aspirin should be offered to all people after an MI and continue it indefinitely, unless they are aspirin intolerant or have an indication for anticoagulation; aspirin should be offered to people who have had an MI more than Cardiac rehabilitation after an acute myocardial infarction (MI); Lifestyle changes after an MI; Drug therapy; Coronary revascularisation after an MI; Selected .. For patients with aspirin hypersensitivity, clopidogrel monotherapy should be considered as an alternative treatment.. The combination of appetite and clopidogrel is not recommended for certain use for any longer than 12 hours clopidogrel post mi nice the acute phase of myocardial infarction (MI), unless there are other opioids to continue dual antiplatelet medication, and the combination is clopidogrel post mi nice recommended for a shorter duration after an. Does ...
http://sinhvienquynhon.info/new-prescription/clopidogrel-post-mi-nice.php
Aspirin desensitization for ASA triad patients--prospective study of the rhinologist`s perspective.
OBJECTIVES/PROBLEM: To determine the sinonasal effect of aspirin salicylic acid (ASA) desensitization in patients with nasal polyps, asthma and aspirin intolerance (ASA triad). Patients with ASA triad were recruited from the outpatient otolaryn
http://www.biomedsearch.com/nih/Aspirin-desensitization-ASA-triad-patients/21468382.html
9783642114113: Nasal Polyposis: Pathogenesis, Medical and Surgical Treatment - AbeBooks: 36421141139783642114113: Nasal Polyposis: Pathogenesis, Medical and Surgical Treatment - AbeBooks: 3642114113
AbeBooks.com: Nasal Polyposis: Pathogenesis, Medical and Surgical Treatment (9783642114113) and a great selection of similar New, Used and Collectible Books available now at great prices.
https://www.abebooks.com/9783642114113/Nasal-Polyposis-Pathogenesis-Medical-Surgical-3642114113/plp
AIA Travel Newsletter - December 2013
The Archaeological Institute of America (AIA) is the oldest and largest archaeological organization in North America. The AIA seeks to educate people of all ages about the significance of archaeological discovery. For more than a century the AIA has been dedicated to the encouragement and support of archaeological research and publication, and to the protection of the worlds archaeological resources and cultural heritage. By traveling on an AIA Tour you directly support the AIA while personally gaining the benefit of the AIAs network of scholars and worldwide contacts.. ...
http://archive.constantcontact.com/fs159/1101097528135/archive/1115957868171.html
AIA Travel Newsletter - January 2014
The Archaeological Institute of America (AIA) is the oldest and largest archaeological organization in North America. The AIA seeks to educate people of all ages about the significance of archaeological discovery. For more than a century the AIA has been dedicated to the encouragement and support of archaeological research and publication, and to the protection of the worlds archaeological resources and cultural heritage. By traveling on an AIA Tour you directly support the AIA while personally gaining the benefit of the AIAs network of scholars and worldwide contacts.. ...
http://archive.constantcontact.com/fs159/1101097528135/archive/1116268273968.html
Gene Ontology ClassificationsGene Ontology Classifications
Predicted to have prostaglandin E receptor activity. Involved in several processes, including cellular response to prostaglandin E stimulus; response to lipopolysaccharide; and response to progesterone. Predicted to localize to plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2 ...
http://www.informatics.jax.org/go/marker/MGI:97794
Are you a member of the AIA? | HCD Magazine
11.11% - Im in the process of joining. COMMENTS. - Because my degree is in Psychology with only a minor in architecture, AIA would NOT accept me in their organization. However, Im an Associate Partner in a prestigious International Architectural Firm and enjoying my 36th year with this firm. I attend every AIA COTE event I can. One day the segregationist little boys club mentality will end, but most likely not within my life time. The world and major inflexible organizations need to address a more holistic acceptance approach to human diversity. I hope sooner, than later.. ...
http://www.healthcaredesignmagazine.com/architecture/are-you-member-aia/
Sample Retention Policy - AIA TrustSample Retention Policy - AIA Trust
Upcoming Webinars Be sure to register for these invaluable upcoming AIA Trust webinars on critical risk topics-free to AIA members. Retirement Risks & Reality September 16, 2021; 12PM-1PM ET Participants will learn ways to calculate future retirement needs, decisions to make when funding a firms retirement plan, how to select the appropriate retirement plan for ones firm…. ...
https://theaiatrust.com/resource/sample-retention-policy/
Introduction to Migrating AIA 2.4 and 2.5 Artifacts to Foundation Pack 11g Release 1Introduction to Migrating AIA 2.4 and 2.5 Artifacts to Foundation Pack 11g Release 1
This guide provides details about the overall migration strategy, process, and utilities used to migrate from Oracle Application Integration Architecture (AIA) 2.
https://docs.oracle.com/cd/E23943_01/doc.1111/e17361/ch1.htm
Prudential pressure to tweak AIA terms | This is MoneyPrudential pressure to tweak AIA terms | This is Money
The UK insurer is piling the pressure on its giant American rival AIG to tweak the terms of the AIA deal, to help finance the cost of the extra capital it needs to satisfy regulators.
https://www.thisismoney.co.uk/money/article-1277140/Prudential-pressure-tweak-AIA-terms.html
Joseph Hopkins | Stanford Medicine ProfilesJoseph Hopkins | Stanford Medicine Profiles
Joseph Hopkins is on CAP Network. CAP Network is a virtual workspace, to support collaboration among faculty, graduate students, postdocs and staff.
https://med.stanford.edu/profiles/joseph-hopkins
Zucchini | GreenMedInfo | Substance | Natural Medicine | AlternativeZucchini | GreenMedInfo | Substance | Natural Medicine | Alternative
This topic has 3 study abstracts on Zucchini indicating that it may have therapeutic value in the treatment of Alloxan toxicity, Diabetes Mellitus: Type 1, and Aspirin-Induced Toxicity
https://video.greenmedinfo.com/substance/zucchini
Therapeutic Antibodies for Nasal Polyposis Treatment: Where Are We Headed?<...
TY - JOUR. T1 - Therapeutic Antibodies for Nasal Polyposis Treatment. T2 - Where Are We Headed?. AU - Agarwal, Aarti. AU - Spath, Derek. AU - Sherris, David A.. AU - Kita, Hirohito. AU - Ponikau, Jens U.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - This review article aims to outline what is known in the pathophysiology of chronic rhinosinusitis with nasal polyposis (CRSwNP) and describe the mechanism of the biologic agents being investigated for this disease. Chronic rhinosinusitis with nasal polyposis is an inflammatory disease of the nasal and paranasal mucosa, which causes symptoms of nasal obstruction, hyposmia, and rhinorrhea. Conventional therapy for CRSwNP includes intranasal corticosteroids (INCS) and polypectomy, but INCS offer only modest benefits, and recurrence after surgery is common. Therefore, effective pharmacologic therapies for CRSwNP are being actively sought. Monoclonal antibodies have been successful in other chronic diseases involving eosinophilic inflammation, such as chronic ...
https://mayoclinic.pure.elsevier.com/en/publications/therapeutic-antibodies-for-nasal-polyposis-treatment-where-are-we
Nasal Polyposis From Pathogenesis To Treatment An Update
How to Treat Nasal Polyps: Nasal Polyposis From Pathogenesis To Treatment An Update. Nasal Polyps Site, Info, tips and treatments for Nasal Polyps.
http://nasalpolypssite.com/nasal-polyposis-from-pathogenesis-to-treatment-an-update/
医療情報レポート] 鼻ポリポーシス治療薬の世界市場：インサイト・疫学・市場予測
DelveInsights Nasal Polyposis - Market Insights, Epidemiology, and Market Forecast-2030 report delivers an in-depth understanding of the Nasal Polyposis,
https://www.mdata.jp/nasal-polyposis-market-insight-epidemiology-delv20ju086-404117
Gary Cole AIA, Esq.Gary Cole AIA, Esq.
Gary Cole AIA, Esq. - Gary L. Cole AIA, Esq. is a Certified Mediator and Arbitrator and a Chicago based Illinois and Florida licensed attorney (20 years), and Illinois licensed arc
https://www.mediate.com/member/Gary-Cole-AIA,-Esq./34861
AIA Sale 70 - September 22, 2021 - U.S., Chinese & Worldwide Banknotes, Scripophily, Historic Finan - Session 1 - Page 1 of 18...AIA Sale 70 - September 22, 2021 - U.S., Chinese & Worldwide Banknotes, Scripophily, Historic Finan - Session 1 - Page 1 of 18...
Archives International Auctions - AIA Sale 70 - September 22, 2021 - U.S., Chinese & Worldwide Banknotes, Scripophily, Historic Finan - Session 1 - River Edge, New Jersey
https://auction.archivesinternational.com/auction.aspx?as=76496
Design for Change - AIADesign for Change - AIA
Adaptability, resilience, and reuse are essential to good design, which seeks to enhance usability, functionality, and value over time.
https://www.aia.org/showcases/6082660-design-for-change--
Application of basophil activation test in diagnosing aspirin hypersensitivity | Gawinowska | Advances in Respiratory MedicineApplication of basophil activation test in diagnosing aspirin hypersensitivity | Gawinowska | Advances in Respiratory Medicine
In the face of increasing prevalence of hypersensitivity reactions, introduction of effective, reliable and safe methods plays a crucial role in their diagnosing. Among the currently available laboratory (in vitro) methods is basophil activation test (BAT). It is a flow- cytometry based assay that allows to identificate in the blood sample basophils and additionally to asses the degree of cell activation after exposure to an antigen. The most common superficial identification markers are CD63 and CD203c, which increase in number after activation. Basophil actvation test can be applied to confirm diagnosis of allergy to Hymenoptera venoms, food, pollens and hypersensitivity to drugs. The aim of present paper is to present theoretical methods of this test as well as its pros and cons. We focus also on presentation of clinical case where BAT seemed to be a necessary addition to a routine diagnostic pathway. We present a case of identification of the culprit drug which caused an anaphylactic ...
https://journals.viamedica.pl/advances_in_respiratory_medicine/article/view/PiAP.2015.0010
FDA Approves Dupixent® (dupilumab) for Chronic Rhinosinusitis with Nasal PolyposisFDA Approves Dupixent® (dupilumab) for Chronic Rhinosinusitis with Nasal Polyposis
/PRNewswire/ -- First biologic medicine for adults with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP) Dupixent significantly...
https://www.prnewswire.com/news-releases/fda-approves-dupixent-dupilumab-for-chronic-rhinosinusitis-with-nasal-polyposis-300875536.html
The impact of diurnal variation on induced sputum cell counts in healthy adults | Clinical and Translational Allergy | Full TextThe impact of diurnal variation on induced sputum cell counts in healthy adults | Clinical and Translational Allergy | Full Text
Induced sputum cell counts are a non-invasive, reliable method for evaluating the presence, type, and degree of inflammation in the airways of the lungs. Current reference values for induced sputum cell counts in healthy adults do not account for the effects of circadian rhythm, including diurnal variation. The objective of this study was to describe the diurnal variation in induced sputum cell counts, compared between early morning and late afternoon, in healthy adult individuals. 100 healthy adult subjects with no history of lung disease and normal bronchial reactivity proceeded with induced sputum testing at 7 am and 4 pm on different days. The order of testing was randomized. The cytotechnologist preparing and performing the cell counts was blinded to the sample collection time and subject characteristics. 65 subjects were included in the final analyses. There was no significant change in the total and differential sputum cell counts between the 7 am and 4 pm collections. There was good inter
https://ctajournal.biomedcentral.com/articles/10.1186/2045-7022-3-8/metrics
Asthma Symptoms Triggered by Aspirin? - Allergic LivingAsthma Symptoms Triggered by Aspirin? - Allergic Living
Q: After taking aspirin recently, I began to get asthma symptoms. Ive since read online that some asthmatics are sensitive to aspirin. Can you tell me why? Dr. Bassett: A small number of those with asthma can be adversely affected by aspirin and non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen.. In some cases, the resulting wheezing, shortness of breath and related respiratory distress can be serious, even life-threatening.. There is an association between the following conditions: aspirin intolerance, nasal polyps and/or sinusitis and asthma.. It is essential for your specialist to give you a medical evaluation to determine the best course of coordinated care. Your doctors can help you to identify the names of the various NSAIDs that you should avoid.. An allergist may need to discuss additional therapies (e.g. aspirin desensitization) if its appropriate. That may not only improve the sinus symptoms, but your asthma as well.. Dr. Clifford Bassett, allergist and asthma ...
https://www.allergicliving.com/experts/asthma-symptoms-triggered-by-aspirin/
Relief for Aspirin-Sensitive Asthma Patients | Division of Allergy & Immunology | Albert Einstein College of Medicine
The lack of understanding of AERD and its underlying cause has created a critical barrier in developing effective treatments for the condition. Many practitioners are unaware of AERD and this is often why it takes so long to connect all the pieces of the puzzle before the correct treatment can be offered, Dr. Jerschow said.. Additionally, the very act of diagnosing AERD is risky, since many patients will suffer an asthma attack in response to the standard oral-graded aspirin challenge. Dr. Jerschows study will compare the pharmacological effects (biochemical changes in the body) of aspirin in AERD patients to those of aspirin-tolerant asthmatics. Her protocol, conducted on 25-30 participants aged 25-62 (some of whom are referred by the Department of Otorhinolaryngology - Head & Neck Surgery), will use a low-dose aspirin challenge to avoid allergic reactions. The low-dose aspirin challenge begins by giving the patient a small amount of aspirin. This approach usually does not lead to a ...
https://www.einstein.yu.edu/departments/medicine/divisions/allergy-immunology/research/dr-elina-jerschow-study-on-asthma-aspirin-allergy.aspx
Nasal Polyposis with Radical Surgical Excision : Medical ExhibitNasal Polyposis with Radical Surgical Excision : Medical Exhibit
Educators and Students: freely download thousands of medical animations and illustrations when your school library subscribes to the SMART Imagebase.
https://ebsco.smartimagebase.com/view-item?ItemID=1193
VEIN Graduation 2019 - Win FinancialVEIN Graduation 2019 - Win Financial
Legal Disclaimer. This is not the official website of AIA Singapore Private Limited (Company Registration No. 201106386R) (AIA). AIA disclaims all warranties of merchantability and fitness for purpose of the materials on this website. AIA makes no warranties or representations as to the results of the use of the materials on this website in terms of their correctness, accuracy and reliability. Nothing on this website should be regarded as an offer or solicitation to sell insurance products in any country to any person to whom it is unlawful to make such an invitation or solicitation in such a country.. Terms of Use. (1) All trademarks, service marks, trade names, product names, icons and logos of AIA are owned by AIA and may not be used without prior written permission from AIA. (2) All AIA products and services referred to in this website (or linked thereto to the website) known as www.winfinancialgroup.com.sg( the Agency Website) are offered only in countries where such products and ...
https://winfinancial.com.sg/vein-graduation-2019/
Committee on Design | AIA MinnesotaCommittee on Design | AIA Minnesota
This committee is charged with overseeing the creation and implementation of all AIA Minnesota award programs. They either secure jurors or act as the selection committee for AIA Minnesota awards. These awards are presented to recipients at the annual AIA Minnesota Awards Celebration ...
https://www.aia-mn.org/get-involved/committees/committee-on-design/
Expression of CACNG4 in prostate cancer - The Human Protein AtlasExpression of CACNG4 in prostate cancer - The Human Protein Atlas
Expression of CACNG4 (MGC11138, MGC24983) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
http://www.proteinatlas.org/ENSG00000075461-CACNG4/pathology/tissue/prostate+cancer
Green Design for a Sustainable & Shared Quality of Life by Vivian Loftness, FAIA - AIA ColumbusGreen Design for a Sustainable & Shared Quality of Life by Vivian Loftness, FAIA - AIA Columbus
Vivian Loftness, FAIA presented Green Design for a Sustainable and Shared Quality of Life at AIA Columbus January 2011 Chapter Meeting. Her presentation is available for you to view here. ...
https://www.aiacolumbus.org/q-green-design-for-a-sustainable-a-shared-quality-of-lifeq-by-vivian-loftness-faia/
Boi si Vaci Episodul 6: In cireada, de CraciunBoi si Vaci Episodul 6: In cireada, de Craciun
Boivacii au fost foarte mult tratati si bagati in seama in ultimul timp. A venit vremea un episod de incheiere de sezon. Mai e un pic si boivacii vor sarbatori Craciun. Dar ce-i aia ? Intrebati-i ! Au facut aia de la tembelizor misto de oameni intrebandu-i ce si cum, dar acum e cazul sa-si…
https://xaeus.wordpress.com/2014/12/23/boi-si-vaci-episodul-6-in-cireada-de-craciun/
Smoking and Respiratory DiseasesSmoking and Respiratory Diseases
Diseases caused by smoking kill more than 480,000 people in the U.S. each year. Heres a look at the risks linked to smoking, as well as information to help you quit.
http://healthlibrary.munsonhealthcare.org/Library/DiseasesConditions/Adult/Respiratory/85,P01331
Smoking and Respiratory DiseasesSmoking and Respiratory Diseases
Diseases caused by smoking kill more than 480,000 people in the U.S. each year. Heres a look at the risks linked to smoking, as well as information to help you quit.
https://healthlibrary.munsonhealthcare.org/Conditions/COPD/85,P01331
AspirinAspirin
As such, further research is required to clarify the role of aspirin in this context. Aspirin can induce swelling of skin ... More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. Bleeding risk is greater among ... Complicating the use of aspirin for prevention is the phenomenon of aspirin resistance. For people who are resistant, aspirin's ... the aspirin had been taken in combination with another NSAID-induced drug when angioedema appeared. Aspirin causes an increased ...
https://en.wikipedia.org/wiki/Aspirin
Leukotriene E4Leukotriene E4
Lee TH, Christie PE (1993). "Leukotrienes and aspirin induced asthma". Thorax. 48 (12): 1189-1190. doi:10.1136/thx.48.12.1189. ... urinary LTE4 levels are increased during severe asthma attacks and are especially high in people with aspirin-induced asthma, ... "Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor". The Journal of Experimental Medicine. 206 (11 ... also known as Samter's Triad or aspirin-exacerbated respiratory disease (AERD). Studies have suggested that LTE4 works through ...
https://en.wikipedia.org/wiki/Leukotriene_E4
Asthma triggerAsthma trigger
Aspirin induced asthma, or aspirin-exacerbated respiratory disease, refers to situations where the use of aspirin worsen the ... Exercise induced asthma is common in most asthma patients. Although the mechanism for such a phenomenon is still unclear, ... Szczeklik, Andrew; Stevenson, Donald D. (2003). "Aspirin-induced asthma: Advances in pathogenesis, diagnosis, and management". ... Therefore, asthma patients should be cautious and inform their physicians of their asthma conditions. Occupational asthma ...
https://en.wikipedia.org/wiki/Asthma_trigger
Andrzej SzczeklikAndrzej Szczeklik
Szczeklik, Andrew; Stevenson, Donald D (2003). "Aspirin-induced asthma: Advances in pathogenesis, diagnosis, and management". ... He is perceived as an expert on aspirin-sensitive asthma. For the research on asthma he received "Lancet Investigators Award" ... aspirin-induced asthma, chemical mediators in diseases of circulatory and respiratory systems with special reference to ... In 2001 he was awarded the gold medal and "The Robert A. Cook Memorial Lectureship" by American Academy Allergy Asthma and ...
https://en.wikipedia.org/wiki/Andrzej_Szczeklik
TBX21TBX21
June 2005). "Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma". Human Genetics. 117 (1 ... Asthma is a disease of chronic inflammation, and it is known that transgenic mice born without TBX21 spontaneously develop ... It is thought that TBX21, therefore, may play a role in the development of asthma in humans as well. Initially it was thought ... December 2004). "TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids". ...
https://en.wikipedia.org/wiki/TBX21
EicosanoidEicosanoid
... see Aspirin-induced asthma); exercise- and cold-air induced asthma (see Exercise-induced bronchoconstriction); and childhood ... or aspirin-treated COX2 to form the lipoxins and epi-lipoxins or with P450 oxygenases or aspirin-treated COX2 to form Resolvin ... are used clinically as maintenance treatment for allergen-induced asthma and rhinitis; nonsteroidal anti-inflammatory drug- ... Aspirin and NSAIDS-drugs that block the COX pathways and stop prostanoid synthesis-limit fever or the heat of localized ...
https://en.wikipedia.org/wiki/Eicosanoid
Pathophysiology of asthmaPathophysiology of asthma
Jenkins C, Costello J, Hodge L (2004). "Systematic review of prevalence of aspirin induced asthma and its implications for ... In essence, asthma is the result of an immune response in the bronchial airways. The airways of asthma patients are " ... However, asthma is rarely the only symptom, and not all people with food or other allergies have asthma Sulfite sensitivity ... GERD may be common in difficult-to-control asthma, but according to one study, treating it does not seem to affect the asthma. ...
https://en.wikipedia.org/wiki/Pathophysiology_of_asthma
C-C motif chemokine ligand 24C-C motif chemokine ligand 24
"Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients". Chest. 128 (5): 3127-32. ... induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase ... "Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil". Biochem. Biophys ...
https://en.wikipedia.org/wiki/C-C_motif_chemokine_ligand_24
Aspirin exacerbated respiratory diseaseAspirin exacerbated respiratory disease
"Natural history of aspirin-induced asthma. AIANE Investigators. European Network on Aspirin-Induced Asthma". The European ... Aspirin-induced asthma and rhinitis (AIAR) A person who has not yet experienced asthma or aspirin sensitivity might be ... Aspirin exacerbated respiratory disease (AERD), also termed aspirin-induced asthma, is a medical condition initially defined as ... There may be a relationship between aspirin-induced asthma and TBX21, PTGER2, and LTC4S. Eosinophils isolated from the blood of ...
https://en.wikipedia.org/wiki/Aspirin_exacerbated_respiratory_disease
AsthmaAsthma
Aspirin-exacerbated respiratory disease (AERD), also known as aspirin-induced asthma, affects up to 9% of asthmatics. AERD ... This may be even more common in some ethnic groups such as the Japanese and those with aspirin-induced asthma. Other studies ... It occurs in most people with asthma and up to 20% of people without asthma. Exercise-induced bronchoconstriction is common in ... Brittle asthma is a kind of asthma distinguishable by recurrent, severe attacks. Type 1 brittle asthma is a disease with wide ...
https://en.wikipedia.org/wiki/Asthma
GPR17GPR17
... see Aspirin-induced asthma). Subsequent reports, however, have varied in results: studies focusing on the allergen and non- ... In consequence, GPR17 attracted attention as a potential mediator of reactions caused by LTC4 and LTD4 viz., asthma, rhinitis, ... Kanaoka Y, Boyce JA (2014). "Cysteinyl leukotrienes and their receptors; emerging concepts". Allergy, Asthma & Immunology ... GPR17 expression is induced in dying neurons within and on the borders of injury, in infiltrating microglia and macrophages, ...
https://en.wikipedia.org/wiki/GPR17
Prostaglandin EP3 receptorProstaglandin EP3 receptor
A in PTGER3 has been associated with Aspirin-induced asthma in a Korean population; and 6 SNP variants have been associated ... In a mouse model of ovalbumin-induced asthma, a selective EP3 agonist reduced airway cellularity, mucus, and ... "Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity". ... Furthermore, a selective EP3 agonist, ONO-AE-248, induces hyperalgesia pain in wild type but not EP3-deficient mice. While pain ...
https://en.wikipedia.org/wiki/Prostaglandin_EP3_receptor
CCL24CCL24
... such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma ... CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. This chemokine is also strongly chemotactic ... Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), ... "Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease ...
https://en.wikipedia.org/wiki/CCL24
AnaphylaxisAnaphylaxis
Stevens W, Buchheit K, Cahill KN (December 2015). "Aspirin-Exacerbated Diseases: Advances in Asthma with Nasal Polyposis, ... Pravettoni, V; Incorvaia, C (2016). "Diagnosis of exercise-induced anaphylaxis: current insights". Journal of Asthma and ... It can sometimes be difficult to distinguish anaphylaxis from asthma, syncope, and panic attacks. Asthma however typically does ... "Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease". J Allergy Clin ...
https://en.wikipedia.org/wiki/Anaphylaxis
Prostaglandin EP2 receptorProstaglandin EP2 receptor
... allergic diseases such as asthma (particular aspirin and nonsteroidal inflammatory drug-induced asthma syndromes) and rhinitis ... in a Korean population have been associated with an increased incidence of Aspirin-induced asthma. Prostanoid receptors ... "Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity". ... Desai S, April H, Nwaneshiudu C, Ashby B (December 2000). "Comparison of agonist-induced internalization of the human EP2 and ...
https://en.wikipedia.org/wiki/Prostaglandin_EP2_receptor
EoxinEoxin
... aspirin-induced asthma attacks, and perhaps other allergic reactions. A subsequent study found that eoxin levels in the exhaled ... "Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The ... breath of aspirin-sensitive and aspirin-intolerant asthmatic individuals did not rise after aspirin challenge and did not ... Eoxins have been implicated in inflammation of the airways in asthma patients, and in those with Hodgkin lymphoma, a malignant ...
https://en.wikipedia.org/wiki/Eoxin
Alcohol-induced respiratory reactionsAlcohol-induced respiratory reactions
... alcohol-induced rhinitis and exacerbations of asthma reactions are highly associated with aspirin-induced asthma reactions; ... Alcohol-induced respiratory reactions, also termed alcohol-induced asthma and alcohol-induced respiratory symptoms, are ... there was a significant association between wine-induced asthma and asthma triggered by sulfite-containing foods, by aspirin, ... more than half of individuals suffering from the aspirin-induced sensitivity reaction will also suffer alcohol-induced ...
https://en.wikipedia.org/wiki/Alcohol-induced_respiratory_reactions
HivesHives
Jogging is the most common exercise to cause EU, but it is not induced by a hot shower, fever, or with fretfulness. This ... Risk factors include having conditions such as hay fever or asthma. Diagnosis is typically based on the appearance. Patch ... Drugs that have caused allergic reactions evidenced as hives include codeine, sulphate of morphia, dextroamphetamine, aspirin, ... The occurrence of drug-induced solar urticaria may be associated with porphyrias. This may be caused by IgG binding, not IgE. ...
https://en.wikipedia.org/wiki/Hives
15-Hydroxyeicosatetraenoic acid15-Hydroxyeicosatetraenoic acid
... aspirin-induced asthma attacks, and perhaps other allergic reactions. The production of eoxins by Reed-Sternburg cells has also ... When pretreated with aspirin, however, COX-1 is inactive while COX-2 attacks arachidonic acid to produce almost exclusively 15( ... Serhan, C. N.; Takano, T; Maddox, J. F. (1999). Aspirin-triggered 15-epi-lipoxin A4 and stable analogs on lipoxin A4 are potent ... Some of the inhibitory effects of 15(S)-HpETE and 15(S)-HETE, particularly when induced by high concentrations (e.g. >1-10 ...
https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid
Salicylate sensitivitySalicylate sensitivity
Samter's triad refers to NSAID sensitivity in conjunction with nasal polyps and asthma. Aspirin-induced asthma NSAID ... Montelukast is one form of treatment used in aspirin-intolerant asthma. An important salicylate drug is aspirin, which has a ... However, it is possible for aspirin to trigger non-allergic hypersensitivity reactions. About 5-10% of asthmatics have aspirin ... November 2008). "Obesity in aspirin-tolerant and aspirin-intolerant asthmatics". Respirology. 13 (7): 1034-8. doi:10.1111/j. ...
https://en.wikipedia.org/wiki/Salicylate_sensitivity
Cysteinyl leukotriene receptor 1Cysteinyl leukotriene receptor 1
... allergen-induced asthma and rhinitis; nonsteroidal anti-inflammatory drug-induced asthma and rhinitis (see Aspirin-induced ... asthma); exercise- and cold-air induced asthma (see Exercise-induced bronchoconstriction); and childhood sleep apnea due to ... in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis". The Journal of Allergy and Clinical Immunology. 115 (2): 316 ... "A review on leukotrienes and their receptors with reference to asthma". The Journal of Asthma. 50 (9): 922-31. doi:10.3109/ ...
https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_1
Variant anginaVariant angina
... or aspirin-induced asthma. Variant angina is also the major complication of eosinophilic coronary periarteritis, an extremely ... In addition, aspirin should be used with caution and at low doses since at high doses it inhibits the production of the ... A positive test to these inducing agents is defined as a ≥90% (some experts require lesser, e.g. ≥70%) constriction of involved ... While acetylcholine induces vasoconstriction of vascular smooth muscle cells through a direct mechanism, acetylcholine also ...
https://en.wikipedia.org/wiki/Variant_angina
ALOX15ALOX15
... human allergen-induced asthma, aspirin-induced asthma, and perhaps other allergic diseases. In colorectal, breast, and kidney ... which have pro-inflammatory actions and contribute to severe asthma, aspirin-induced asthma attacks, and other allergy ... Neighbour H (2014). "Mechanisms of aspirin-intolerant asthma: identifying inflammatory pathways in the pathogenesis of asthma ... and other pathogen-induced inflammatory responses; in eczema, arthritis, asthma, cystic fibrosis, atherosclerosis, and adipose ...
https://en.wikipedia.org/wiki/ALOX15
Timeline of Polish science and technologyTimeline of Polish science and technology
... and studies on the pathogenesis and treatment of aspirin-induced bronchial asthma Antoni Zygmund, Polish mathematician, ... credited with discovering the anti-thrombotic properties of aspirin, ...
https://en.wikipedia.org/wiki/Timeline_of_Polish_science_and_technology
Wheat allergyWheat allergy
The most severe response is exercise/aspirin induced anaphylaxis attributed to one omega gliadin that is a relative of the ... Because many of the symptoms associated with wheat allergies, such as eczema and asthma, may be related or unrelated to a wheat ... As with exercise induced anaphylaxis, aspirin (also: tartrazine, sodium benzoate, sodium glutamate (MSG), sodium metabisulfite ... However two conditions, exercise/aspirin induced anaphylaxis and urticaria, occur more frequently with wheat allergies.[ ...
https://en.wikipedia.org/wiki/Wheat_allergy
AERDAERD
... may refer to: Aspirin-exacerbated respiratory disease, also known aspirin-induced asthma Atheroembolic renal disease, a ...
https://en.wikipedia.org/wiki/AERD
RhinitisRhinitis
Drinking alcohol may cause rhinitis as well as worsen asthma (see alcohol-induced respiratory reactions). In certain ... Alcohol-exacerbated rhinitis is more frequent in individuals with a history of rhinitis exacerbated by aspirin. Aspirin and ... In these cases, alcohol-induced rhinitis may be of the mixed rhinitis type and, it seems likely, most cases of alcohol-induced ... "Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease". The Journal of ...
https://en.wikipedia.org/wiki/Rhinitis
EosinophiliaEosinophilia
... asthma, atopic dermatitis, eosinophilic esophagitis, chronic sinusitis, aspirin-induced asthma, allergic bronchopulmonary ... Drug- induced hepatitis marked by immunoallergic pathology, which has much bidirectional crossover with DRESS syndrome, is ... Manti S, Leonardi S, Salpietro A, Del Campo G, Salpietro C, Cuppari C (2017). "A systematic review of food protein-induced ... Oxford Respiratory Medicine Library: Asthma, 2nd ed., ed. Graeme P. Currie and John. F. W. Baker, OUP, 2012. Mitchell, Richard ...
https://en.wikipedia.org/wiki/Eosinophilia
Nonsteroidal anti-inflammatory drugNonsteroidal anti-inflammatory drug
... see aspirin-induced asthma) symptoms in individuals with a history of asthma or rhinitis and 2) exacerbation or first-time ... aspirin-induced asthma The widespread use of NSAIDs has meant that the adverse effects of these drugs have become increasingly ... excluding aspirin) Past stroke (excluding aspirin) Past myocardial infarction (excluding aspirin) Coronary artery disease ( ... Jeffreys D (2004). Aspirin: the story of a wonder drug. London: Bloomsbury. Propatier S. "The Mythology of Aspirin". Retrieved ...
https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug
NSAID hypersensitivity reactionsNSAID hypersensitivity reactions
... see aspirin-induced asthma) in individuals with a history of asthma and/or nasal congestion, rhinorrhea or other symptoms of ... Ledford DK, Wenzel SE, Lockey RF (2014). "Aspirin or other nonsteroidal inflammatory agent exacerbated asthma". The Journal of ... "Mediators of inflammation in nasal lavage from aspirin intolerant patients after aspirin challenge". Respiratory Medicine. 104 ... "Update on aspirin desensitization for chronic rhinosinusitis with polyps in aspirin-exacerbated respiratory disease (AERD)". ...
https://en.wikipedia.org/wiki/NSAID_hypersensitivity_reactions
TriamcinoloneTriamcinolone
It is also used to prevent worsening of asthma and COPD. It can be taken in various ways including by mouth, injection into a ... Aspirin and other NSAIDs, as well as anticoagulants such as warfarin, add to the risk of gastrointestinal bleeding. Diuretics ... urushiol-induced contact dermatitis, aphthous ulcers (usually as triamcinolone acetonide), central retinal vein occlusion, ... visualization during vitrectomy and the prevention of asthma attacks. The derivative triamcinolone acetonide is the active ...
https://en.wikipedia.org/wiki/Triamcinolone
Eicosanoid receptorEicosanoid receptor
PGF2α-induced activation of FP has pro-inflammatory effects as well as roles in ovulation, luteolysis, contraction of uterine ... Claar D, Hartert TV, Peebles RS (2015). "The role of prostaglandins in allergic lung inflammation and asthma". Expert Review of ... aspirin-triggered lipoxin A4>leukotriene C4=leukotriene D4>>15-deoxy-LXA4>>N-Formylmethionine-leucyl-phenylalanine (http://www. ... and asthma, particularly in the area of airways constriction. EP2-(PGE2) (PTGER2) - PTGER2; EP2 is a receptor for prostaglandin ...
https://en.wikipedia.org/wiki/Eicosanoid_receptor
InfluenzaInfluenza
Aspirin is not recommended to treat influenza in children due to an elevated risk of developing Reye syndrome. Corticosteroids ... Infection also induces production of systemic glucocorticoids that can reduce inflammation to preserve tissue integrity but ... asthma), kidney, liver, blood, neurological, or metabolic (e.g. diabetes) disorders, as are people who are immunocompromised ... Cells possess sensors to detect viral RNA, which can then induce interferon production. Interferons mediate expression of ...
https://en.wikipedia.org/wiki/Influenza
Shellfish allergyShellfish allergy
Prevalence of seafood-induced adult asthma is reported as in the range of 7% to 36% (higher for crustaceans and lower for bony ... citing evidence that the culprit food in combination with alcohol or aspirin will result in a respiratory anaphylactic reaction ... Pravettoni V, Incorvaia C (October 2016). "Diagnosis of exercise-induced anaphylaxis: current insights". J Asthma Allergy. 9: ... Tong WS, Yuen AW, Wai CY, Leung NY, Chu KH, Leung PS (October 2018). "Diagnosis of fish and shellfish allergies". J Asthma ...
https://en.wikipedia.org/wiki/Shellfish_allergy
AllergyAllergy
... asthma, allergy, allergies, prevention of allergies and asthma, treatment for allergies and asthma". Archived from the original ... Only occasionally have these food-induced allergies induced systemic responses. Researchers suspect that the cross-reactivity ... and reactions to medications like aspirin and antibiotics such as penicillin. Symptoms of food allergy include abdominal pain, ... "Global Strategy for Asthma Management and Prevention" (PDF). Global Initiative for Asthma. 2011. pp. 2-5. Archived from the ...
https://en.wikipedia.org/wiki/Allergy
Michael G. DeGroote School of MedicineMichael G. DeGroote School of Medicine
... respirologist and expert in allergy induced asthma In 2018, The magazine Maclean's wrote an article about McMaster's innovative ... James Fraser Mustard, CC, Chair of Pathology (1966-1972), Dean of Medicine (1972-1982), discovered the effect of aspirin in ... Centre for Asthma and Allergy Research (Allergen) and North American Headquarters for West Nile studies, as well as the ... hematologist and expert in heparin-induced thrombocytopenia Dave Williams, Professor of Surgery (2008-2011), Canadian astronaut ...
https://en.wikipedia.org/wiki/Michael_G._DeGroote_School_of_Medicine
EsophagitisEsophagitis
To prevent drug-induced esophagitis, drink plenty of liquids when taking medicines, take an alternative drug, and do not take ... Steroids that are used to treat asthma can be swallowed to treat eosinophil esophagitis due to nonfood allergens. The removal ... aspirin, naproxen sodium, and ibuprofen. Known to irritate the GI tract. Antibiotics - doxycycline and tetracycline Quinidine ... Types include: Fungal Candida (Esophageal candidiasis) Viral Herpes simplex (Herpes esophagitis) Cytomegalovirus Drug-induced ...
https://en.wikipedia.org/wiki/Esophagitis
MethylprednisoloneMethylprednisolone
The National Asthma Education and Prevention Program (NAEPP) indicates systemic methylprednisolone in both short and long term ... Exogenous corticosteroids induce osteoporosis by increasing bone resorption and reducing bone formation. Bone loss can be ... Cox1 inhibitors Methylprednisolone may increase rate of elimination with chronic high dose aspirin. Patient's are susceptible ... In 2001-2002, 11.4% of patients diagnosed with asthma and seen at an outpatient visit were prescribed oral corticosteroids as a ...
https://en.wikipedia.org/wiki/Methylprednisolone
Prostaglandin DP1 receptorProstaglandin DP1 receptor
... asthma, and/or aspirin sensitivity; the -197T>C and -613 C>T variants were also associated with increased incidences of ... and pro-allergic cytokine and chemokine production in a mouse model of ovalbumin-induced asthma as well as allergic symptoms in ... Studies of experimentally-induced allergic responses in animals further implicate DP1 in allergy. DP1 gene knockout and/or DP1 ... The PTGDR1 gene is located on chromosome 14 at position q22.1, (i.e. 14q22.1), a chromosomal locus associated with asthma and ...
https://en.wikipedia.org/wiki/Prostaglandin_DP1_receptor
Specialized pro-resolving mediatorsSpecialized pro-resolving mediators
... through a pathway that involves ALOX5 followed by aspirin-treated cyclooxygenase 2 (COX2). Aspirin-treated COX-2, while ... And, in a single study, inhaled LXA4 decreased LTC4-initiated bronchoprovocation in patients with asthma. Qu Q, Xuan W, Fan GH ... Both PGJ2's are arachidonic acid-derived metabolites made by cyclooxygenases, primarily COX-2, which is induced in many cell ... Aspirin-triggered-PD1 (AT-PD1 or AP-NPD1) is the 17R-hydroxyl diastereomer of PD1 formed by the initial metabolism of DHA by ...
https://en.wikipedia.org/wiki/Specialized_pro-resolving_mediators
Food intoleranceFood intolerance
Drugs sourced from plants, such as aspirin, can also cause these kinds of reactions. Food hypersensitivity is used to refer ... Nettis E, Colanardi MC, Ferrannini A, Tursi A (October 2004). "Sodium benzoate-induced repeated episodes of acute urticaria/ ... Respiratory tract symptoms can include nasal congestion, sinusitis, pharyngeal irritations, asthma and an unproductive cough. ... Salicylate sensitivity causes reactions to not only aspirin and NSAIDs but also foods in which salicylates naturally occur, ...
https://en.wikipedia.org/wiki/Food_intolerance
Cysteinyl leukotriene receptor 2Cysteinyl leukotriene receptor 2
The CysLT-induced activation of CysLTR2 induces many of the same in vitro responses of cells involved in allergic reactions as ... 2005). "Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant ... "A review on leukotrienes and their receptors with reference to asthma". The Journal of Asthma. 50 (9): 922-31. doi:10.3109/ ... 384 families with a high prevalence of asthma from the Genetics of Asthma International Network. The M201V CysLTR2 variant ...
https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_2
BarbiturateBarbiturate
... s induce a number of hepatic CYP enzymes (most notably CYP2C9, CYP2C19, and CYP3A4), leading to exaggerated effects ... which contains aspirin instead of paracetamol and may contain codeine phosphate, remains a schedule III drug. Recreational ... Benzodiazepines alcohol asthma kidney or liver problems Heart disease Substance use disorder Depression History of suicidal ... The memory-impairing effects and cognitive impairments induced by sodium thiopental are thought to reduce a subject's ability ...
https://en.wikipedia.org/wiki/Barbiturate
Drug discoveryDrug discovery
... who pioneered the first inhaled selective beta2-adrenergic agonist for asthma, the first inhaled steroid for asthma, ranitidine ... They induce apoptosis and protein cascade via proteinase inhibitor, have defense functions, and regulate plant responses to ... One of the most common drugs derived from salicylates is aspirin, also known as acetylsalicylic acid, with anti-inflammatory ... Jasmonates also have the ability to directly act on mitochondrial membranes by inducing membrane depolarization via release of ...
https://en.wikipedia.org/wiki/Drug_discovery
AluminiumAluminium
Banks, W.A.; Kastin, A.J. (1989). "Aluminum-induced neurotoxicity: alterations in membrane function at the blood-brain barrier ... asthma, irritable bowel syndrome, or other symptoms upon contact with products containing aluminium. Exposure to powdered ... particularly antacid/antiulcer and buffered aspirin formulations). Dietary exposure in Europeans averages to 0.2-1.5 mg/kg/week ...
https://en.wikipedia.org/wiki/Aluminium
Chest painChest pain
In children, the most common causes for chest pain are musculoskeletal (76-89%), exercise-induced asthma (4-12%), ... Aspirin increases survival in people with acute coronary syndrome and it is reasonable for EMS dispatchers to recommend it in ... Aortic aneurysm Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by variable ... Initial treatment often includes the medications aspirin and nitroglycerin. The response to treatment does not usually indicate ...
https://en.wikipedia.org/wiki/Chest_pain
Pharmaceutical industry in ChinaPharmaceutical industry in China
Bayer of Germany, the inventor of aspirin, began trade with China in as early as 1882. Hoechst AG, known as Aventis, sold its ... Complex regulatory processes induce excessive exploitation of regional administrative power. Before the revision of Chinese ... The company mainly sells drugs treating HBV, asthmas and infections. Merck sells antibiotics, prostate drugs, cardiovascular ... Bayer of Germany, the inventor of aspirin, began trade with China in as early as 1882. Hoechst AG, known as Aventis, sold its ...
https://en.wikipedia.org/wiki/Pharmaceutical_industry_in_China

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