The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Drugs that are used to treat asthma.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Measurement of the maximum rate of airflow attained during a FORCED VITAL CAPACITY determination. Common abbreviations are PEFR and PFR.
Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE.
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin).
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
Therapy with two or more separate preparations given for a combined effect.
The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Laboratory examination used to monitor and evaluate platelet function in a patient's blood.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Measurement of volume of air inhaled or exhaled by the lung.
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.
A class of drugs designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
Devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)
A sudden intense and continuous aggravation of a state of asthma, marked by dyspnea to the point of exhaustion and collapse and not responding to the usual therapeutic efforts.
Agents causing the narrowing of the lumen of a bronchus or bronchiole.
The structural changes in the number, mass, size and/or composition of the airway tissues.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
Drugs that selectively bind to and activate beta-adrenergic receptors.
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Substances that reduce or suppress INFLAMMATION.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
Elements of limited time intervals, contributing to particular results or situations.
Bleeding or escape of blood from a vessel.
Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.
Agents that prevent clotting.
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A constitutively-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A subspecialty of internal medicine concerned with the study of the RESPIRATORY SYSTEM. It is especially concerned with diagnosis and treatment of diseases and defects of the lungs and bronchial tree.
The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase.
Duration of blood flow after skin puncture. This test is used as a measure of capillary and platelet function.
Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
The act of BREATHING out.
A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
Any hindrance to the passage of air into and out of the lungs.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
The contamination of indoor air.
Diseases caused by factors involved in one's employment.
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.
Trihydroxy derivatives of eicosanoic acids. They are primarily derived from arachidonic acid, however eicosapentaenoic acid derivatives also exist. Many of them are naturally occurring mediators of immune regulation.
Formation and development of a thrombus or blood clot in the blood vessel.
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.
A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
Any tests done on exhaled air.
A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.
A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The confinement of a patient in a hospital.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Performance of activities or tasks traditionally performed by professional health care providers. The concept includes care of oneself or one's family and friends.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Disease having a short and relatively severe course.
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
Derivatives of the steroid androstane having two double bonds at any site in any of the rings.
A small aerosol canister used to release a calibrated amount of medication for inhalation.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
The teaching or training of patients concerning their own health needs.
A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Nitrogen oxide (NO2). A highly poisonous gas. Exposure produces inflammation of lungs that may only cause slight pain or pass unnoticed, but resulting edema several days later may cause death. (From Merck, 11th ed) It is a major atmospheric pollutant that is able to absorb UV light that does not reach the earth's surface.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.
Inhaling and exhaling the smoke of burning TOBACCO.
Contamination of the air by tobacco smoke.
Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.
Virus diseases caused by the PICORNAVIRIDAE.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
Specific practices for the prevention of disease or mental disorders in susceptible individuals or populations. These include HEALTH PROMOTION, including mental health; protective procedures, such as COMMUNICABLE DISEASE CONTROL; and monitoring and regulation of ENVIRONMENTAL POLLUTANTS. Primary prevention is to be distinguished from SECONDARY PREVENTION and TERTIARY PREVENTION.
Insects of the order Dictyoptera comprising several families including Blaberidae, BLATTELLIDAE, Blattidae (containing the American cockroach PERIPLANETA americana), Cryptocercidae, and Polyphagidae.
A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Skin irritant and allergen used in the manufacture of polyurethane foams and other elastomers.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Voluntary cooperation of the patient in following a prescribed regimen.
A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.
An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS.
The giving of drugs, chemicals, or other substances by mouth.
Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures.
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Spasmodic contraction of the smooth muscle of the bronchi.
The inhabitants of a city or town, including metropolitan areas and suburban areas.
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic protein is a 21-kDa cytotoxic peptide with a pI of 10.9. Although eosinophil cationic protein is considered a member of the RNAse A superfamily of proteins, it has only limited RNAse activity.
The return of a sign, symptom, or disease after a remission.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)

Effect of in vitro aspirin stimulation on basophils in patients with aspirin-exacerbated respiratory disease. (1/27)

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Update on recent advances in the management of aspirin exacerbated respiratory disease. (2/27)

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Diagnosis of aspirin-induced asthma combining the bronchial and the oral challenge tests: a pilot study. (3/27)

BACKGROUND: We investigated the usefulness of the bronchial challenge (BC) with lysine-acetylsalicylate (L-ASA) in the diagnosis of aspirin-exacerbated respiratory disease (AERD) using a protocol that combined both the oral challenge (OC) and the BC tests. METHODS: Adult asthmatic patients with suspected AERD who underwent BC with L-ASA were included in the study. If the BC result with L-ASA was negative, an OC was carried out to establish the diagnosis. AERD was ruled out if both the BC and the OC results were negative (nonresponders). Both responders and nonresponders were compared for age, gender, a personal or family history of atopy, underlying disease, current asthma treatment, and presence of nasal polyps. Six patients with asthma but no suggestive history of AERD were included as controls. RESULTS: Twenty-two patients completed the study. Ten patients tested positive to the BC and/or OC (responders), whereas 12 did not (nonresponders). Seven out of the 10 responders had a positive BC result and 3 a positive OC result. After BC, 4 patients had an early asthmatic response, 1 had a dual response, and 2 had isolated late responses. No significant differences were observed in the aforementioned variables between responders and nonresponders. The results of both challenges were negative in the 6 controls. CONCLUSIONS: The BC had a high positive predictive value, was safe, and when negative, the subsequent OC did not result in any severe adverse reactions. The BC elicited an isolated late asthmatic response that has not been previously described in the literature.  (+info)

Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. (4/27)

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Airway responsiveness to inhaled aspirin is influenced by airway hyperresponsiveness in asthmatic patients. (5/27)

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Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population. (6/27)

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Increase in salivary cysteinyl-leukotriene concentration in patients with aspirin-intolerant asthma. (7/27)

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Nuclear translocation of the glucocorticoid receptor in fibroblasts of asthmatic patients with nasal polyposis insensitive to glucocorticoid treatment. (8/27)

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Aspirin-exacerbated respiratory disease (AERD), also known as Samters Triad, is a chronic condition consisting of asthma, sinus disease with recurrent nasal polyps, and sensitivity to aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs).
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
I have Samters Syndrome (consisting of asthma, aspirin sensitivity and nasal polyps) also known as Samters Triad or aspirin-induced asthma. For the last 29 years I have been taking medications and trying to stay alive. When I found the Australian
In some patients with asthma, aspirin (ASA) and all nonsteroidal anti-inflammatory drugs that inhibit cyclooxygenase enzymes (cyclooxygenase-1 and -2) precipitate asthmatic attacks and naso-ocular reactions. This distinct clinical syndrome, called aspirin-induced asthma (AIA), is characterized by a …
Smoking, environmental tobacco smoke, and aspirin-exacerbated respiratory disease. A study published in 2012 by a group of researchers at the Scripps Clinic in California found that childhood exposure to environmental tobacco smoke was associated with increased odds of developing AERD, and the effec...
International Forum of Allergy & Rhinology. 2016. April; 6(4): 385-91. 30 patients diagnosed with aspirin sensitivity and aspirin-exacerbated respiratory disease (AERD) were entered into a diet trial. They ate either a regular diet or a low-salicylate diet for 6 weeks, and then ate the opposite one for another 6 weeks.. The patients were assigned their diet order randomly, and the physician evaluating them did not know which diet they were on at their evaluations. They were evaluated before beginning the study, after the first 6 weeks, and again at the end (12th week). The evaluations consisted of questionnaires including one named the SNOT-22 * and two others with the more boring names NSSS and ACQ-7, as well as measurements using instruments to evaluate their breathing and sinus condition.. * SNOT = Sino-Nasal Outcome Test. According to all the measurements, the patients had significant improvement on the low-salicylate diet.. QUOTE: The study further reinforces that a low-salicylate diet can ...
Aspirin exacerbated respiratory disease (AERD) is a clinical syndrome characterized by chronic rhinosinusitis with nasal polyposis and aspirin hypersensitivity. The aspirin-induced bronchospasm is mediated by mast cell and eosinophilic inflammation. Recently, it has been reported that the expression of discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) is up-regulated in lung cancers and is regulated by transcription factor AP-2 alpha (TFAP2A), a component of activator protein-2 (AP-2) that is known to regulate IL-8 production in human lung fibroblasts and epithelial cells. To investigate the associations between AERD and DCBLD2 polymorphisms, 12 common variants were genotyped in 163 AERD subjects and 429 aspirin tolerant asthma (ATA) controls. Among these variants, seven SNPs (rs1371687, rs7615856, rs828621, rs828618, rs828616, rs1062196, and rs8833) and one haplotype (DCBLD2-ht1) show associations with susceptibility to AERD. In further analysis, this study reveals significant ...
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type. The two frequent clinical presentations of aspirin hypersensitivity are: aspirin-induced bronchial asthma/rhinosinusitis (AIA …
BACKGROUND: Nasal polyposis is a chronic inflammatory disease of the upper respiratory tract that affects around 2% of the population and almost 67% of patients with aspirin-intolerant asthma. Polyps are rich in mast cells and eosinophils, resulting in high levels of the proinflammatory cysteinyl leukotrienes. OBJECTIVES: To better understand the role of the proinflammatory leukotrienes in nasal polyposis, we asked the following questions: (1) How do nasal polyps produce leukotriene C(4) (LTC(4))? (2) Can LTC(4) feed back in a paracrine way to maintain mast cell activation? (3) Could a combination therapy targeting the elements of this feed-forward loop provide a novel therapy for allergic disease? METHODS: We have used immunohistochemistry, enzyme immunoassay, and cytoplasmic calcium ion (Ca(2+)) imaging to address these questions on cultured and acutely isolated human mast cells from patients with polyposis. RESULTS: Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels
BACKGROUND: Eosinophil activation is the key feature of upper and lower airway inflammation in aspirin-exacerbated respiratory disease (AERD).. OBJECTIVE: To investigate the mechanism of eosinophil activation and identify novel inflammatory mediators using proteomics.. METHODS: Thirty-two asthmatic subjects were enrolled: 18 AERD patients who showed positive responses to the lysine-aspirin nasal provocation test (L-ASA NPT) and 14 aspirin-tolerant asthma (ATA) patients who showed negative responses to the L-ASA NPT (control group). Nasal lavage fluid (NLF) was collected before (baseline), at 10, 30 and 60 min (early response), and at 3 h (late response) after the L-ASA NPT. Eosinophil cationic protein (ECP) and cysteinyl leucotriene (CysLT) levels were measured using an ImmunoCAP system and ELISA respectively. To identify proteins involved in AERD, comparative proteomics was applied using NLFs collected before and after L-ASA NPTs in AERD patients. The clinical relevance of identified novel ...
Eicosanoids are key mediators of type-2 inflammation, e.g., in allergy and asthma. Helminth products have been suggested as remedies against inflammatory diseases, but their effects on eicosanoids are unknown. Here, we show that larval products of the helminth Heligmosomoides polygyrus bakeri (HpbE), known to modulate type-2 responses, trigger a broad anti-inflammatory eicosanoid shift by suppressing the 5-lipoxygenase pathway, but inducing the cyclooxygenase (COX) pathway. In human macrophages and granulocytes, the HpbE-driven induction of the COX pathway resulted in the production of anti-inflammatory mediators [e.g., prostaglandin E2 (PGE2) and IL-10] and suppressed chemotaxis. HpbE also abrogated the chemotaxis of granulocytes from patients suffering from aspirin-exacerbated respiratory disease (AERD), a severe type-2 inflammatory condition. Intranasal treatment with HpbE extract attenuated allergic airway inflammation in mice, and intranasal transfer of HpbE-conditioned macrophages led to ...
Paracetamol is not an NSAID, as may be understood from the wording though paracetamol is generally considered safe - Preceding unsigned comment added by 88.90.68.85 (talk) 15:32, 21 September 2011 (UTC). The pathogenesis section is extremely confusing. In particular, the way the sentence describing differential PGE modulation I found difficult to understand. - Preceding unsigned comment added by 99.98.209.88 (talk) 14:09, 22 January 2013 (UTC). Has anybody else encountered this condition with the additional symptom of severe acute pain around diaphragm & back (possibly associated with gallbladder/spleen) and, later, likely autoimmune haemolytic anaemia? - Preceding unsigned comment added by 95.151.241.169 (talk) 19:52, 25 September 2013 (UTC). Also, interested in finding out more about the efficacy of aspirin desensitization for this condition. Does it reduce sensitivity to other allergens, such as ibuprofen & certain tree pollens (salicylate perhaps)? Does it really prevent or delay nasal ...
TY - JOUR. T1 - Genetic polymorphisms in aspirin-intolerant chronic urticaria. AU - Park, Hae Sim. AU - Kim, Seung Hyun. AU - Hur, Gyu Young. AU - Ye, Young Min. AU - Kim, Sangha. PY - 2007/9/1. Y1 - 2007/9/1. N2 - Background: Aspirin (acetylsalicylic acid, ASA)-intolerant urticaria with angioedema (AIU), a major type of aspirin-related hypersensitivity in urticaria, can be classified into two groups, acute ASA-intolerant urticaria (AIAU) and chronic ASA-intolerant urticaria (AICU), according to the duration of the urticaria. The pathogenic mechanism of AICU is not well understood. Methods/Data base: We present here a review of the recent findings from AICU molecular genetic studies. Results: A previous study on human leukocyte antigen (HLA) genotypes suggested that the HLA alleles DRB1*1302 and DQB1*0609 may be genetic markers for ASA-induced urticaria/angioedema for both AIAU and AICU, and that they were significantly associated with the prevalence of serum-specific immunoglobulin E (IgE) to ...
Suppression of nitric oxide production from nasal fibroblasts by metabolized clarithromycin in vitro. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Effect of rapid desensitization on platelet inhibition and basophil activation in patients with aspirin hypersensitivity and coronary disease Cases were patients with coronary artery disease (CAD) ... European Heart Journal - Cardiovascular Pharmacotherapy, Original Article, Stéphane Manzo-Silberman, Pascale Nicaise-Roland, Catherine Neukirch, Florence Tubach, Marie-Geneviève Huisse, Sylvie ... ...
Banerjee, Probal and lyengar, Raghu R and Ayyer, Jayalekshmy and Bhattacharyya, PK (1984) Carbonation of Phenol: A Novel Reaction Involving Enzyme Model Catalysis. In: Current Science, 53 (23). pp. 1226-1228. Bhattacharyya, PK and Samanta, TB and Ullah, AHJ and Gunsalus, IC (1984) Chemical probes into the active centre of a heme thiolate monoxygenase. In: Journal of Chemical Sciences, 93 (8). pp. 1289-1304. Bhattacharyya, PK and Bhattacharyya, Apares (1981) Fluorescent labelling of strychnine: A novel approach for recognition of strychnine binding sites on neuronal membrane. In: Biochemical and Biophysical Research Communications, 101 (1). pp. 273-280. Ramanjaneyulu, R. and Madyastha, KM and Bhattacharyya, PK (1981) Chemical approach to aspirin hypersensitivity. In: Biochemical and Biophysical Research Communications, 101 (1). pp. 258-264. Bhattacharyya, Apares and Madyastha,, KM and Bhattacharyya, PK and Devanandan, MS (1981) Studies on bicuculline binding sites on neuronal membrane using ...
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METHODOLOGY: A prospective cohort study was performed. Patients with CRS received roxithromycin (150 mg) once daily for 12 weeks. Nasal secretions and serology were collected. Nine predictors for LDM response were assessed: nasal secretion IgE, nasal secretion IL-5, serum IgE, serum eosinophils, serum neutrophils, nasal polyps, asthma, allergy, and aspirin hypersensitivity, using receiver-operating curve analysis and multivariable logistic regression. Macrolide responders were those with sino-nasal outcome test-22 improvement, symptoms visual analogue scale decreased to ≤5, and no rescue medication ...
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Background: A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). Objective: To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. Methods: A cross sectional multicenter study was done in two tertiary centers for allergy in Iran. Adult patients with NP were selected for the study that had been referred to allergy clinics. The oral aspirin challenge (OAC) test was performed to identify aspirin exacerbated respiratory disease (AERD) and the OFC test was used to investigate food intolerance. Atopic evaluation was performed by skin-prick tests, nasal smear and blood eosinophil count as well as serum total IgE. Results: One hundred and nineteen Iranian patients (female to male ratio 1.05) with NP were enrolled (mean age, 38 ± 11 years). Recurrence of nasal polyposis was 64.7%. OAC was
Main / New Prescription / Clopidogrel post mi nice NICE have issued guidance as to the use of antiplatelet agents post myocardial infarction (1). aspirin should be offered to all people after an MI and continue it indefinitely, unless they are aspirin intolerant or have an indication for anticoagulation; aspirin should be offered to people who have had an MI more than Cardiac rehabilitation after an acute myocardial infarction (MI); Lifestyle changes after an MI; Drug therapy; Coronary revascularisation after an MI; Selected .. For patients with aspirin hypersensitivity, clopidogrel monotherapy should be considered as an alternative treatment.. The combination of appetite and clopidogrel is not recommended for certain use for any longer than 12 hours clopidogrel post mi nice the acute phase of myocardial infarction (MI), unless there are other opioids to continue dual antiplatelet medication, and the combination is clopidogrel post mi nice recommended for a shorter duration after an. Does ...
OBJECTIVES/PROBLEM: To determine the sinonasal effect of aspirin salicylic acid (ASA) desensitization in patients with nasal polyps, asthma and aspirin intolerance (ASA triad). Patients with ASA triad were recruited from the outpatient otolaryn
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The Archaeological Institute of America (AIA) is the oldest and largest archaeological organization in North America. The AIA seeks to educate people of all ages about the significance of archaeological discovery. For more than a century the AIA has been dedicated to the encouragement and support of archaeological research and publication, and to the protection of the worlds archaeological resources and cultural heritage. By traveling on an AIA Tour you directly support the AIA while personally gaining the benefit of the AIAs network of scholars and worldwide contacts.. ...
The Archaeological Institute of America (AIA) is the oldest and largest archaeological organization in North America. The AIA seeks to educate people of all ages about the significance of archaeological discovery. For more than a century the AIA has been dedicated to the encouragement and support of archaeological research and publication, and to the protection of the worlds archaeological resources and cultural heritage. By traveling on an AIA Tour you directly support the AIA while personally gaining the benefit of the AIAs network of scholars and worldwide contacts.. ...
Predicted to have prostaglandin E receptor activity. Involved in several processes, including cellular response to prostaglandin E stimulus; response to lipopolysaccharide; and response to progesterone. Predicted to localize to plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2 ...
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This topic has 3 study abstracts on Zucchini indicating that it may have therapeutic value in the treatment of Alloxan toxicity, Diabetes Mellitus: Type 1, and Aspirin-Induced Toxicity
TY - JOUR. T1 - Therapeutic Antibodies for Nasal Polyposis Treatment. T2 - Where Are We Headed?. AU - Agarwal, Aarti. AU - Spath, Derek. AU - Sherris, David A.. AU - Kita, Hirohito. AU - Ponikau, Jens U.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - This review article aims to outline what is known in the pathophysiology of chronic rhinosinusitis with nasal polyposis (CRSwNP) and describe the mechanism of the biologic agents being investigated for this disease. Chronic rhinosinusitis with nasal polyposis is an inflammatory disease of the nasal and paranasal mucosa, which causes symptoms of nasal obstruction, hyposmia, and rhinorrhea. Conventional therapy for CRSwNP includes intranasal corticosteroids (INCS) and polypectomy, but INCS offer only modest benefits, and recurrence after surgery is common. Therefore, effective pharmacologic therapies for CRSwNP are being actively sought. Monoclonal antibodies have been successful in other chronic diseases involving eosinophilic inflammation, such as chronic ...
How to Treat Nasal Polyps: Nasal Polyposis From Pathogenesis To Treatment An Update. Nasal Polyps Site, Info, tips and treatments for Nasal Polyps.
DelveInsights Nasal Polyposis - Market Insights, Epidemiology, and Market Forecast-2030 report delivers an in-depth understanding of the Nasal Polyposis,
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In the face of increasing prevalence of hypersensitivity reactions, introduction of effective, reliable and safe methods plays a crucial role in their diagnosing. Among the currently available laboratory (in vitro) methods is basophil activation test (BAT). It is a flow- cytometry based assay that allows to identificate in the blood sample basophils and additionally to asses the degree of cell activation after exposure to an antigen. The most common superficial identification markers are CD63 and CD203c, which increase in number after activation. Basophil actvation test can be applied to confirm diagnosis of allergy to Hymenoptera venoms, food, pollens and hypersensitivity to drugs. The aim of present paper is to present theoretical methods of this test as well as its pros and cons. We focus also on presentation of clinical case where BAT seemed to be a necessary addition to a routine diagnostic pathway. We present a case of identification of the culprit drug which caused an anaphylactic ...
/PRNewswire/ -- First biologic medicine for adults with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP) Dupixent significantly...
Induced sputum cell counts are a non-invasive, reliable method for evaluating the presence, type, and degree of inflammation in the airways of the lungs. Current reference values for induced sputum cell counts in healthy adults do not account for the effects of circadian rhythm, including diurnal variation. The objective of this study was to describe the diurnal variation in induced sputum cell counts, compared between early morning and late afternoon, in healthy adult individuals. 100 healthy adult subjects with no history of lung disease and normal bronchial reactivity proceeded with induced sputum testing at 7 am and 4 pm on different days. The order of testing was randomized. The cytotechnologist preparing and performing the cell counts was blinded to the sample collection time and subject characteristics. 65 subjects were included in the final analyses. There was no significant change in the total and differential sputum cell counts between the 7 am and 4 pm collections. There was good inter
Q: After taking aspirin recently, I began to get asthma symptoms. Ive since read online that some asthmatics are sensitive to aspirin. Can you tell me why? Dr. Bassett: A small number of those with asthma can be adversely affected by aspirin and non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen.. In some cases, the resulting wheezing, shortness of breath and related respiratory distress can be serious, even life-threatening.. There is an association between the following conditions: aspirin intolerance, nasal polyps and/or sinusitis and asthma.. It is essential for your specialist to give you a medical evaluation to determine the best course of coordinated care. Your doctors can help you to identify the names of the various NSAIDs that you should avoid.. An allergist may need to discuss additional therapies (e.g. aspirin desensitization) if its appropriate. That may not only improve the sinus symptoms, but your asthma as well.. Dr. Clifford Bassett, allergist and asthma ...
The lack of understanding of AERD and its underlying cause has created a critical barrier in developing effective treatments for the condition. Many practitioners are unaware of AERD and this is often why it takes so long to connect all the pieces of the puzzle before the correct treatment can be offered, Dr. Jerschow said.. Additionally, the very act of diagnosing AERD is risky, since many patients will suffer an asthma attack in response to the standard oral-graded aspirin challenge. Dr. Jerschows study will compare the pharmacological effects (biochemical changes in the body) of aspirin in AERD patients to those of aspirin-tolerant asthmatics. Her protocol, conducted on 25-30 participants aged 25-62 (some of whom are referred by the Department of Otorhinolaryngology - Head & Neck Surgery), will use a low-dose aspirin challenge to avoid allergic reactions. The low-dose aspirin challenge begins by giving the patient a small amount of aspirin. This approach usually does not lead to a ...
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Expression of CACNG4 (MGC11138, MGC24983) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
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Diseases caused by smoking kill more than 480,000 people in the U.S. each year. Heres a look at the risks linked to smoking, as well as information to help you quit.
Diseases caused by smoking kill more than 480,000 people in the U.S. each year. Heres a look at the risks linked to smoking, as well as information to help you quit.
Lee TH, Christie PE (1993). "Leukotrienes and aspirin induced asthma". Thorax. 48 (12): 1189-1190. doi:10.1136/thx.48.12.1189. ... urinary LTE4 levels are increased during severe asthma attacks and are especially high in people with aspirin-induced asthma, ... "Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor". The Journal of Experimental Medicine. 206 (11 ... also known as Samter's Triad or aspirin-exacerbated respiratory disease (AERD). Studies have suggested that LTE4 works through ...
"Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma". Human Genetics. 117 (1): 16-26. doi ... Asthma is a disease of chronic inflammation, and it is known that transgenic mice born without TBX21 spontaneously develop ... It is thought that TBX21, therefore, may play a role in the development of asthma in humans as well. GRCh38: Ensembl release 89 ... "HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response". Biochemical and Biophysical Research ...
... see Aspirin-induced asthma); exercise- and cold-air induced asthma (see Exercise-induced bronchoconstriction); and childhood ... or aspirin-treated COX2 to form the lipoxins and epi-lipoxins or with P450 oxygenases or aspirin-treated COX2 to form Resolvin ... are used clinically as maintenance treatment for allergen-induced asthma and rhinitis; nonsteroidal anti-inflammatory drug- ... Aspirin and NSAIDS-drugs that block the COX pathways and stop prostanoid synthesis-limit fever or the heat of localized ...
"Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients". Chest. 128 (5): 3127-32. ... induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase ... "Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil". Biochem. Biophys ...
... see Aspirin-induced asthma). Subsequent reports, however, have varied in results: studies focusing on the allergen and non- ... In consequence, GPR17 attracted attention as a potential mediator of reactions caused by LTC4 and LTD4 viz., asthma, rhinitis, ... Kanaoka Y, Boyce JA (2014). "Cysteinyl leukotrienes and their receptors; emerging concepts". Allergy, Asthma & Immunology ... GPR17 expression is induced in dying neurons within and on the borders of injury, in infiltrating microglia and macrophages, ...
A in PTGER3 has been associated with Aspirin-induced asthma in a Korean population; and 6 SNP variants have been associated ... In a mouse model of ovalbumin-induced asthma, a selective EP3 agonist reduced airway cellularity, mucus, and ... "Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity". ... Furthermore, a selective EP3 agonist, ONO-AE-248, induces hyperalgesia pain in wild type but not EP3-deficient mice. While pain ...
... such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma ... CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. This chemokine is also strongly chemotactic ... Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), ... "Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease ...
Asthma (Status asthmaticus. Aspirin-induced. Exercise-induced. Bronchiectasis. unspecified. Bronchitis. Bronchiolitis ... Drinking alcohol may cause rhinitis as well as worsen asthma (see alcohol-induced respiratory reactions). In certain ... alcohol-induced rhinitis may be of the mixed rhinitis type and, it seems likely, most cases of alcohol-induced rhinitis in non- ... "Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease". The Journal of ...
... allergic diseases such as asthma (particular aspirin and nonsteroidal inflammatory drug-induced asthma syndromes) and rhinitis ... in a Korean population have been associated with an increased incidence of Aspirin-induced asthma. Prostanoid receptors ... "Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity". ... Desai S, April H, Nwaneshiudu C, Ashby B (December 2000). "Comparison of agonist-induced internalization of the human EP2 and ...
... aspirin-induced asthma attacks, and perhaps other allergic reactions. A subsequent study found that eoxin levels in the exhaled ... "Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The ... breath of aspirin-sensitive and aspirin-intolerant asthmatic individuals did not rise after aspirin challenge and did not ... Eoxins have been implicated in inflammation of the airways in asthma patients, and in those with Hodgkin lymphoma, a malignant ...
... also known as aspirin-induced asthma, also known as: Acetylsalicylic acid triad Francis' triad Triad asthma Widal's triad ...
Jogging is the most common exercise to cause EU, but it is not induced by a hot shower, fever, or with fretfulness. This ... Risk factors include having conditions such as hay fever or asthma. Diagnosis is typically based on the appearance. Patch ... Drugs that have caused allergic reactions evidenced as hives include codeine, sulphate of morphia, dextroamphetamine, aspirin, ... The occurrence of drug-induced solar urticaria may be associated with porphyrias. This may be caused by IgG binding, not IgE. ...
... aspirin-induced asthma attacks, and perhaps other allergic reactions. The production of eoxins by Reed-Sternburg cells has also ... When pretreated with aspirin, however, COX-1 is inactive while COX-2 attacks arachidonic acid to produce almost exclusively 15( ... Serhan, C. N.; Takano, T; Maddox, J. F. (1999). Aspirin-triggered 15-epi-lipoxin A4 and stable analogs on lipoxin A4 are potent ... Some of the inhibitory effects of 15(S)-HpETE and 15(S)-HETE, particularly when induced by high concentrations (e.g. >1-10 ...
Samter's triad refers to NSAID sensitivity in conjunction with nasal polyps and asthma. Aspirin-induced asthma NSAID ... Montelukast is one form of treatment used in aspirin-intolerant asthma. An important salicylate drug is aspirin, which has a ... However, it is possible for aspirin to trigger non-allergic hypersensitivity reactions. About 5-10% of asthmatics have aspirin ... November 2008). "Obesity in aspirin-tolerant and aspirin-intolerant asthmatics". Respirology. 13 (7): 1034-8. doi:10.1111/j. ...
... allergen-induced asthma and rhinitis; nonsteroidal anti-inflammatory drug-induced asthma and rhinitis (see Aspirin-induced ... asthma); exercise- and cold-air induced asthma (see Exercise-induced bronchoconstriction); and childhood sleep apnea due to ... in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis". The Journal of Allergy and Clinical Immunology. 115 (2): 316 ... "A review on leukotrienes and their receptors with reference to asthma". The Journal of Asthma. 50 (9): 922-31. doi:10.3109/ ...
... or aspirin-induced asthma. Variant angina is also the major complication of eosinophilic coronary periarteritis, an extremely ... In addition, aspirin should be used with caution and at low doses since at high doses it inhibits the production of the ... A positive test to these inducing agents is defined as a ≥90% (some experts require lesser, e.g. ≥70%) constriction of involved ... While acetylcholine induces vasoconstriction of vascular smooth muscle cells through a direct mechanism, acetylcholine also ...
... human allergen-induced asthma, aspirin-induced asthma, and perhaps other allergic diseases. In colorectal, breast, and kidney ... which have pro-inflammatory actions and contribute to severe asthma, aspirin-induced asthma attacks, and other allergy ... Neighbour H (2014). "Mechanisms of aspirin-intolerant asthma: identifying inflammatory pathways in the pathogenesis of asthma ... and other pathogen-induced inflammatory responses; in eczema, arthritis, asthma, cystic fibrosis, atherosclerosis, and adipose ...
... and studies on the pathogenesis and treatment of aspirin-induced bronchial asthma Antoni Zygmund, a Polish mathematician, ... credited with discovering the anti-thrombotic properties of aspirin, ...
The most severe response is exercise/aspirin induced anaphylaxis attributed to one omega gliadin that is a relative of the ... Because many of the symptoms associated with wheat allergies, such as eczema and asthma, may be related or unrelated to a wheat ... As with exercise induced anaphylaxis, aspirin (also: tartrazine, sodium benzoate, sodium glutamate (MSG), sodium metabisulfite ... However two conditions, exercise/aspirin induced anaphylaxis and urticaria, occur more frequently with wheat allergies. Common ...
... may refer to: Aspirin-exacerbated respiratory disease, also known aspirin-induced asthma Atheroembolic renal disease, a ...
Drinking alcohol may cause rhinitis as well as worsen asthma (see alcohol-induced respiratory reactions). In certain ... Alcohol-exacerbated rhinitis is more frequent in individuals with a history of rhinitis exacerbated by aspirin. Aspirin and ... In these cases, alcohol-induced rhinitis may be of the mixed rhinitis type and, it seems likely, most cases of alcohol-induced ... "Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease". The Journal of ...
... asthma, atopic dermatitis, eosinophilic esophagitis, chronic sinusitis, aspirin-induced asthma, allergic bronchopulmonary ... Drug- induced hepatitis marked by immunoallergic pathology, which has much bidirectional crossover with DRESS syndrome, is ... Manti S, Leonardi S, Salpietro A, Del Campo G, Salpietro C, Cuppari C (2017). "A systematic review of food protein-induced ... Oxford Respiratory Medicine Library: Asthma, 2nd ed., ed. Graeme P. Currie and John. F. W. Baker, OUP, 2012. Gotlib J (2014). " ...
... see aspirin-induced asthma) symptoms in individuals with a history of asthma or rhinitis and 2) exacerbation or first-time ... aspirin-induced asthma The widespread use of NSAIDs has meant that the adverse effects of these drugs have become increasingly ... excluding aspirin) Past stroke (excluding aspirin) Past myocardial infarction (excluding aspirin) Coronary artery disease ( ... excluding aspirin) Undergoing coronary artery bypass surgery Congestive heart failure (excluding low-dose aspirin) In third ...
... see aspirin-induced asthma) in individuals with a history of asthma and/or nasal congestion, rhinorrhea or other symptoms of ... Ledford DK, Wenzel SE, Lockey RF (2014). "Aspirin or other nonsteroidal inflammatory agent exacerbated asthma". The Journal of ... "Mediators of inflammation in nasal lavage from aspirin intolerant patients after aspirin challenge". Respiratory Medicine. 104 ... "Update on aspirin desensitization for chronic rhinosinusitis with polyps in aspirin-exacerbated respiratory disease (AERD)". ...
Allergic and autoimmune diseases such as severe asthma, rhinitis, or urticarial, chronic sinusitis, aspirin-induced asthma, ... Before cardiac symptoms are detected, some 66% of cases have symptoms of a common cold and 33% have symptoms of asthma, ... These causes are classified as primary (i.e. a defect intrinsic to the eosinophil cell line), secondary (induced by an ... Sentürk T, Özdemir B, Keçebaş M, Beşli F, Yesilbursa D, Serdar OA (2012). "Ascaris-induced eosinophilic myocarditis presenting ...
... and hands Yellowing of skin Rash Ecchymosis Hypersensitivity to aspirin/NSAID-induced asthma or urticaria Aspirin triad 3rd ... New Metabolic Pathway Reveals Aspirin-Like Compound's Anti-Cancer Properties. June 2016 Jayamani E, Tharmalingam N, Rajamuthiah ... after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand ... Impaired liver function Impaired kidney function Dehydration Fluid retention History of gastrointestinal bleeds/PUD Asthma ...
... a South Korean test group was found to be elevated in patients suffering a type of severe asthma termed Aspirin-induced asthma ... For example, prostacyclin I2 (PGI2)-induced activation of its prostacyclin receptor (IP) and prostaglandin D2-induced ... prevented from developing angiotensin II-induced and N-Nitroarginine methyl ester-induced hypertension along with associated ... These findings suggest that TP contributes to asthma in animal models at least in part by mediating the actions of LTC4. ...
... history of aspirin-induced asthma and other hypersensitivity reactions to analgesics. Oral anticoagulants (blood thinners), ... Despite this, studies in animals have found that the CB1 cannabinoid receptor is not involved in the analgesia induced by ... It is suggested that some populations are more prone to suffer from metamizole induced agranulocytosis than others. As an ... "Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 - ...
The rare SNP variant 795C of 794T in the PTGIR gene is associated with an increased incidence of Aspirin-induced asthma and a ... or bradykinin-induced paw edema. IP antagonists likewise reduce experimentally-induced capillary permeability and swelling in ... These IP-induced responses likely contribute to its apparent function in inhibiting certain mouse inflammation responses as ... IP(-/-) mice exhibit little or no writhing responses in an acetic acid-induced pain model. The mouse IP receptor also appears ...
... may however help heal venous leg ulcers that have not healed following usual treatment. Aspirin can induce swelling of ... More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. Bleeding risk is greater among ... There is no evidence that aspirin prevents dementia. Aspirin is claimed to have anti-aging effect however low dose aspirin ... Complicating the use of aspirin for prevention is the phenomenon of aspirin resistance. For people who are resistant, aspirin's ...
Giorgetti R, di Muzio M, Giorgetti A, Girolami D, Borgia L, Tagliabracci A (March 2017). "Flutamide-induced hepatotoxicity: ... including anaphylaxis and severe asthma exacerbations in susceptible people.[35] In extremely rare cases, the frequent and ... lasers that do not vaporize the top layer of the skin but rather induce a physiologic response in the skin from the light) have ... that exhibits the necessary antibacterial activity against pathogens related to acne vulgaris and a low propensity for inducing ...
Lee J, Oh H (2013). "Ginger as an antiemetic modality for chemotherapy-induced nausea and vomiting: A systematic review and ... such as warfarin or aspirin.[2] ... Asthma-plant. *Astragalus. *Cannabis *medical use. *Caraway. * ...
Asthma (Status asthmaticus. Aspirin-induced. Exercise-induced. Bronchiectasis. Cystic fibrosis. unspecified. Bronchitis. ... Many people with COPD mistakenly think they have asthma.[36] The distinction between asthma and COPD is made on the basis of ... An outcomes strategy for people with chronic obstructive pulmonary disease (COPD) and asthma in England (PDF). Department of ... "Asthma and COPD: Basic Mechanisms and Clinical Management. Academic. p. 464. ISBN 978-0-12-374001-4. .. ...
Inhibition of hippocampal neurogenesis may also play a role in the development of isotretinoin-induced depression.[38] A ... Scheinfeld N, Bangalore S (May 2006). "Facial edema induced by isotretinoin use: a case and a review of the side effects of ... Nelson AM, Gilliland KL, Cong Z, Thiboutot DM (October 2006). "13-cis Retinoic acid induces apoptosis and cell cycle arrest in ... Isotretinoin's exact mechanism of action is unknown, but several studies have shown that isotretinoin induces apoptosis ( ...
哮喘(急性重症哮喘(英语:Acute severe asthma). 阿司匹林誘發哮喘(英语:Aspirin-induced asthma). 運動誘發哮喘(英语:Exercise-induced
PTGER2 (Aspirin-induced asthma). Class B. *PTH1R (Jansen's metaphyseal chondrodysplasia). Class C. *CASR (Familial ... Pulsatile GnRH therapy can also be used to induce fertility, especially in females, but its use is limited to a few specialist ... Standard hormone replacement therapy will not normally induce fertility in either males or females, with no testicular growth ... can also be used in male patients to induce secondary sexual characteristic development alongside possible fertility induction. ...
102,0 102,1 Khan D. A. (Jan-Feb 2012)։ «Exercise-induced bronchoconstriction: burden and prevalence»։ Allergy and Asthma ... Knowles S. R., Drucker A. M., Weber E. A., Shear N. H. (July 2007)։ «Management options for patients with aspirin and ... Third Expert Panel on the Diagnosis and Management of Asthma (2007)։ Guidelines for the diagnosis and management of asthma։ ... 101,0 101,1 Shah R., Saltoun, C. A. (May-Jun 2012)։ «Chapter 14: Acute severe asthma (status asthmaticus)»։ Allergy and Asthma ...
Winther B, Gwaltney JM, Mygind N, Hendley JO (1998). "Viral-induced rhinitis". American Journal of Rhinology. 12 (1): 17-20. ... Cates CJ, Rowe BH (February 2013). "Vaccines for preventing influenza in people with asthma". The Cochrane Database of ... should avoid taking aspirin during an influenza infection (especially influenza type B), because doing so can lead to Reye's ... People with emphysema, chronic bronchitis or asthma may experience shortness of breath while they have the flu, and influenza ...
Asthma (Status asthmaticus. Aspirin-induced. Exercise-induced. Bronchiectasis. unspecified. Bronchitis. Bronchiolitis ...
"Allergy, Asthma, and Clinical Immunology. 12: 27. doi:10.1186/s13223-016-0130-4. PMC 4878059. PMID 27222657.. ... Aspirin and other nonsteroidal anti-inflammatory drugs should be avoided, since these may interfere with platelet function ... WASp is important because it is known to be activated via T-cell receptor signaling pathways to induce cortical actin ...
Radiation-induced erythema multiforme. Radiation-induced hypertrophic scar. Radiation-induced keloid. Radiation-induced morphea ... The use of ibuprofen or aspirin may increase the probability of an episode in some patients. The use of acetaminophen typically ... Asthma & Immunology. 98 (1): 57-63. doi:10.1016/S1081-1206(10)60860-5. PMID 17225721.. ... ACE inhibitors can induce angioedema.[13][14][15] ACE inhibitors block the enzyme ACE so it can no longer degrade bradykinin; ...
a b c Khan, DA (2012 Jan-Feb). "Exercise-induced bronchoconstriction: burden and prevalence.". Allergy and asthma proceedings ... Cara pengobatan asma yang paling efektif yaitu menemukan pemicunya, misal merokok, hewan peliharaan, atau aspirin, dan ... Third Expert Panel on the Diagnosis and Management of Asthma (2007). Guidelines for the diagnosis and management of asthma. ... a b Shah, R; Saltoun, CA (2012 May-Jun). "Chapter 14: Acute severe asthma (status asthmaticus).". Allergy and asthma ...
ALOX5 contributes to non-allergic reactions of the respiratory system and skin such as aspirin-induced asthma, NSAID ... asthma, rashes, and eczema; d) NSAID-induced acute non-allergic reactions such as asthma, rhinitis, conjunctivitis, angioedema ... NSAID-induced non-allergic conjunctivitis, NSAID-induced angioedema, or NSAID-induced urticarial; it may also contribute to ... NSAID-induced non-allergic reactionsEdit. Aspirin and other non-steroidal anti-inflammatory drugs (NSAID) can cause NSAID- ...
Finally, nicotine induces the formation of patterns of collagen type III in the atrium and has profibrotic effects. All this ... novel oral anticoagulants or warfarin with a CHA2DS2-VASc score of one over aspirin and some directly recommend against aspirin ... while aspirin is overused in many who should be treated with a direct oral anticoagulant (DOAC) or warfarin.[80][81][82] In ... aspirin's major bleeding risk (including bleeding in the brain) is similar to that of warfarin and DOACs despite its inferior ...
Chu, Eric K.; Drazen, Jeffrey M. (1 June 2005). "Asthma". American Journal of Respiratory and Critical Care Medicine. 171 (11 ... In contrast, much larger doses of amphetamine are likely to impair cognitive function and induce rapid muscle breakdown.[45][50 ... such as aspirin or ibuprofen). It is also used as a precursor chemical in the illegal production of methamphetamine. ... it can induce psychosis, rhabdomyolysis, and cerebral hemorrhage.[59][96] Methamphetamine is known to have a high potential for ...
哮喘(急性重症哮喘(英語:Acute severe asthma). 阿司匹林誘發哮喘(英語:Aspirin-induced asthma). 運動誘發哮喘(英語:Exercise-induced
Asthma (Status asthmaticus. Aspirin-induced. Exercise-induced. Bronchiectasis. unspecified. Bronchitis. Bronchiolitis ... Determining the underlying organism is usually not required.[4] Other causes of similar symptoms include asthma, pneumonia, ... and anybody with asthma all have a higher risk of developing chronic bronchitis.[43] This wide range is due to the different ... Unlike other common obstructive disorders such as asthma or emphysema, bronchitis rarely causes a high residual volume (the ...
... as opposed to the antipyretic action of aspirin seen with lower doses. In addition, aspirin induces the formation of NO- ... and worsening asthma.[4] Bleeding risk is greater among those who are older, drink alcohol, take other NSAIDs, or are on other ... "Aspirin monograph: dosages, etc". Medscape.com. Retrieved 11 May 2011.. *^ a b c "Aspirin: more evidence that low dose is all ... "Aspirin" by other manufacturers .[166] Today, aspirin is a generic trademark in many countries.[167] Aspirin, with a capital "A ...
Drug-induced hives has been known to have an effect on severe cardiorespiratory failure.[medical citation needed] ... American Academy of Allergy, Asthma, and Immunology. "Five Things Physicians and Patients Should Question" (PDF). Choosing ... aspirin, ibuprofen, penicillin, clotrimazole, trichazole, sulfonamides, anticonvulsants, cefaclor, piracetam, vaccines, and ... Cold-inducedEdit. Further information: Cold urticaria. The cold type of urticaria is caused by exposure of the skin to extreme ...
Asthma (Status asthmaticus. Aspirin-induced. Exercise-induced. Bronchiectasis. unspecified. Bronchitis. Bronchiolitis ...
In traditional Chinese medicine, má huáng has been used as a treatment for asthma and bronchitis for centuries.[41] ... Schier JG, Traub SJ, Hoffman RS, Nelson LS (2003). "Ephedrine-induced cardiac ischemia: exposure confirmed with a serum level ... contains ephedrine with caffeine and aspirin. It is a popular supplement taken by bodybuilders seeking to cut body fat before a ... It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment.[1] It is of unclear benefit in ...
The CysLT-induced activation of CysLTR2 induces many of the same in vitro responses of cells involved in allergic reactions as ... 2005). "Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant ... "Allergy, Asthma & Immunology Research. 6 (4): 288-95. doi:10.4168/aair.2014.6.4.288. PMC 4077954. PMID 24991451.. ... 384 families with a high prevalence of asthma from the Genetics of Asthma International Network. The M201V CysLTR2 variant ...
Aspirin (Asetilsalisilik Asit) · Benorilat · Diflunisal · Etenzamid · Magnezyum Salisilat · Salisin · Salisilamid · Salsalat · ... "Iranian Journal of Allergy, Asthma, and Immunology. 2 (4), s. 175-80. PMID 17301376. 6 October 2014 tarihinde kaynağından ... Jianren Mao (19 April 2016). Opioid-Induced Hyperalgesia. CRC Press. ss. 127-. ISBN 978-1-4200-8900-4. 8 September 2017 ...
PTGER2 (Aspirin-induced asthma). Class B. *PTH1R (Jansen's metaphyseal chondrodysplasia). Class C. *CASR (Familial ...
They induce apoptosis [63][64] and protein cascade via proteinase inhibitor,[63] have defense functions,[65] and regulate plant ... who pioneered the first inhaled selective beta2-adrenergic agonist for asthma, the first inhaled steroid for asthma, ranitidine ... One of the most common drugs derived from salicylates is aspirin, also known as acetylsalicylic acid, with anti-inflammatory ... They also play an active role in the suppression of cell proliferation.[63] They have the ability to induce death in ...
Khan, DA (2012 Jan-Feb). "Exercise-induced bronchoconstriction: burden and prevalence". Allergy and asthma proceedings : the ... Cara pengobatan asma yang paling efektif yaitu menemukan pemicunya, misal merokok, hewan peliharaan, atau aspirin, dan ... Third Expert Panel on the Diagnosis and Management of Asthma (2007). Guidelines for the diagnosis and management of asthma. ... Carlsen, KH (2008 May). "Treatment of exercise-induced asthma, respiratory and allergic disorders in sports and the ...
Asthma (Status asthmaticus. Aspirin-induced. Exercise-induced. Bronchiectasis. unspecified. Bronchitis. Bronchiolitis ... "American Academy of Allergy, Asthma, and Immunology. Retrieved 2007-04-12.. *. "Exercise-Induced Asthma". National Jewish ... 2007). "American Academy of Allergy, Asthma & Immunology Work Group report: exercise-induced asthma". J Allergy Clin Immunol. ... Exercise-induced asthma, or E.I.A., occurs when the airways narrow as a result of exercise. The preferred term for this ...
Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase. J Physiol Pharmacol. 2006,. ... Nonsteroidal anti-inflammatory drug-induced reactions and desensitization. J Asthma. 2004, 41 (4): 375-84. PMID 15281324. doi: ... Aspirin monograph: dosages, etc. Medscape.com. [2011-05-11].. *^ 139.0 139.1 139.2 Aspirin: More Evidence That Low Dose Is All ... COX抑制劑(英語:Mechanism of action of aspirin). 乙酰水楊酸/阿司匹林# · 阿洛普令(英語:Aloxiprin) · 卡巴匹林鈣(英語:Carbasalate calcium) · 吲哚布芬(英
Asthma (Status asthmaticus. Aspirin-induced. Exercise-induced. Bronchiectasis. unspecified. Bronchitis. Bronchiolitis ... Aspirin has been studied in those who are at high risk and was not found to be useful.[1] ... particularly in people with obstructive lung disease such as asthma or chronic obstructive pulmonary disease (COPD). iPEEP has ...
Asthma (Status asthmaticus. Aspirin-induced. Exercise-induced. Bronchiectasis. Cystic fibrosis. unspecified. Bronchitis. ... Drug- and toxin-induced (e.g., methamphetamine use [23] ). *Associated conditions:Connective tissue disease, HIV infection, ... Less common signs/symptoms include non-productive cough and exercise-induced nausea and vomiting.[11] Coughing up of blood may ... Lawrie, Allan (2014). "The role of the osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the ...
Here are links to possibly useful sources of information about Aspirin-induced asthma.. *PubMed provides review articles from ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Talk:Aspirin-induced_asthma&oldid=598253608" ... Also, interested in finding out more about the efficacy of aspirin desensitization for this condition. Does it reduce ...
EDITOR-The prevalence of aspirin induced asthma on oral provocation testing in the systematic review by Jenkins et al was ... Aspirin induced asthma. BMJ 2004; 328 doi: https://doi.org/10.1136/bmj.328.7447.1076-a (Published 29 April 2004) Cite this as: ...
Patients with aspirin-induced asthma, who constitute from 10% to 20% of the approximately 15 million U.S. asthma sufferers, can ... VICTIMS OF ASPIRIN-INDUCED ASTHMA CAN BE SUCCESSFULLY DESENSITIZED. Patients with aspirin-induced asthma, who constitute from ... "Fifty percent of the patients who have aspirin-induced asthma have chronic, severe, corticosteroid-dependent asthma," said Dr. ... said that attacks of aspirin-induced asthma are often precipitated by ingesting small amounts of aspirin or other nonsteroidal ...
This distinct clinical syndrome, called aspirin-induced asthma (AIA), is characterized by a … ... aspirin (ASA) and all nonsteroidal anti-inflammatory drugs that inhibit cyclooxygenase enzymes (cyclooxygenase-1 and -2) ... Aspirin-induced asthma: advances in pathogenesis and management J Allergy Clin Immunol. 1999 Jul;104(1):5-13. doi: 10.1016/ ... This distinct clinical syndrome, called aspirin-induced asthma (AIA), is characterized by a typical sequence of symptoms, ...
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Aspirin-induced asthma is a distinct clinical syndrome which affects about 10% of adult asthmatics. In these patients aspirin ... The cyclooxygenase theory of aspirin-induced asthma Message Subject (Your Name) has sent you a message from European ... Their major assumption is that inhibition of cyclooxygenase triggers specific biochemical reactions which lead to open asthma ...
Acetylsalicylic acid Completed Phase 4 Trials for Asthma, Aspirin-Induced Treatment. Back to Acetylsalicylic acid ... The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases. *Acetylsalicylic acid (DB00945 ...
I have Samters Triad syndrome, also known as Aspirin Induced Asthma (AIA). About 10 per cent of people with Samters syndrome ... I have Samters Triad syndrome, also known as Aspirin Induced Asthma (AIA). About 10 per cent of people with Samters syndrome ... No one, not even the doctors knew what causing the problems as the asthma was so very different from common asthma. During that ... My mouth, face and eyes and lips all swelled inside out and I had asthma and hives. For the next 3 years, it was a constant ...
Buy or Rent Platelets and Aspirin-Induced Asthma: Pathogenesis and Melatonin as an eTextbook and get instant access. With ... Platelets and Aspirin-Induced Asthma: Pathogenesis and Melatonin Edition by Evsyukova, Helen and Publisher Academic Press. Save ...
Aspirin-Induced" by people in this website by year, and whether "Asthma, Aspirin-Induced" was a major or minor topic of these ... "Asthma, Aspirin-Induced" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Asthma, Aspirin-Induced*Asthma, Aspirin-Induced. *Aspirin-Induced Asthmas. *Asthma, Aspirin Induced ... Below are the most recent publications written about "Asthma, Aspirin-Induced" by people in Profiles. ...
... consisting of asthma, aspirin sensitivity and nasal polyps) also known as Samters Triad or aspirin-induced asthma. For the ... aspirin sensitivity and nasal polyps) also known as Samters Triad or aspirin-induced asthma. For the last 29 years I have been ... I have Samters Syndrome (consisting of asthma, ... 994] Salicylates: Aspirin-induced asthma and nasal polyps ( ...
Aspirin-induced asthma information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, ... Aspirin-induced asthma *What is Aspirin-induced asthma? *Videos related to Aspirin-induced asthma *Prognosis of Aspirin-induced ... More Aspirin-induced asthma animations & videos Prognosis for Aspirin-induced asthma. Prognosis for Aspirin-induced asthma: The ... Types of Aspirin-induced asthma *Causes of Aspirin-induced asthma *Symptoms of Aspirin-induced asthma *Diagnostic Tests for ...
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... of adults with asthma are sensitive to aspirin. Aspirin-induced asthma is more common in adults than children. ... How is aspirin-induced asthma treated?. The first step in treating aspirin-induced asthma is to manage the underlying asthma.2 ... How is aspirin-induced asthma diagnosed?. An ongoing sinus infection is a hallmark of aspirin-induced asthma. Without a sinus ... What happens during an aspirin-induced asthma attack?. An aspirin-induced asthma attack can be deadly.4 The attack can begin ...
Aspirin-induced asthma is asthma triggered by taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin, ... The asthma attack triggered by aspirin and NSAIDs can be life threatening. In many cases, people with aspirin-induced asthma ... aspirin-induced asthma is managed in the same way as other types of asthma. Three types of medicines are used to control asthma ... What is aspirin-induced asthma?. Asthma is a long-lasting (chronic) lung disease. It causes coughing, wheezing, and shortness ...
Asthma is a common chronic disease worldwide and affects approximately 24 million persons in the United States. It is the most ... Aspirin-induced asthma. The triad of asthma, aspirin sensitivity, and nasal polyps affects 5-10% of patients with asthma. Most ... Exercise-induced asthma. Exercise-induced asthma (EIA), or exercise-induced bronchoconstriction (EIB), is an asthma variant ... Immune-mediated asthma has a latency of months to years after exposure. Non-immune-mediated asthma, or irritant-induced asthma ...
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... differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients. Download Prime PubMed App to ... Aspirin inhibits cyclooxygenase activity and modifies production of the arachidonate cascade in aspirin-induced asthma. The aim ... Possible involvement of mast-cell activation in aspirin provocation of aspirin-induced asthma. ... Aspirin inhibits cyclooxygenase activity and modifies production of the arachidonate cascade in aspirin-induced asthma. The aim ...
of acetaminophen-induced asthma without aspirin sensitivity. Cyclo-oxygenase inhibition may not be a pathogenic mechanism of ... We experienced a case of acetaminophen- induced bronchial asthma without aspirin sensitivity. An oral challenge test upto 650mg ... Acetaminophen-induced asthma; oral provocation test. Appears in Collections:. Journal Papers > School of Medicine / Graduate ... Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical ...
Asthma - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional ... Treatment of acute asthma exacerbation Treatment of chronic asthma Exercise-induced asthma Aspirin-sensitive asthma Future ... Aspirin-sensitive asthma. The primary treatment for aspirin-sensitive asthma is avoidance of aspirin and other NSAIDs. ... Aspirin is a trigger in up to 30% of patients with severe asthma and in , 10% of all patients with asthma. Aspirin-sensitive ...
Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. ... Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Together they form a unique ...
Hyperleukotrienuria is a hallmark of aspirin-induced asthma. Both ELISA and HPLC-MS have diagnostic value in this disease. ... Targeted eicosanoid lipidomics of exhaled breath condensate provide a distinct pattern in the aspirin-intolerant asthma ... Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics, Prostaglandins & ... Elevated urinary leukotriene E4 excretion in asthma: a comparison of HPLC-mass spectrometry and ELISA. Authors. *. M. Sanak,. ...
Aspirin-Induced Asthma. Aspirin-induced asthma (AIA) is a condition in which asthma gets worse after taking aspirin or other ... Exercise-Induced Asthma. Exercise-induced asthma (EIA), also called exercise-induced bronchoconstriction, is a limited form of ... Patients with aspirin-induced asthma (AIA) should avoid aspirin and other NSAIDs, including ibuprofen (Advil and other brands, ... Asthma Action Plans. Asthma action plans create a written document for patients to manage asthma during stable times and to ...
Aspirin-Induced Asthma. Aspirin-induced asthma (AIA) is a condition in which asthma gets worse after taking aspirin or other ... Tylenol-induced asthma may occur in people with aspirin-induced asthma.. Although this link is not yet proven, parents whose ... Exercise-Induced Asthma (EIA). Exercise-induced asthma (EIA), also called exercise-induced bronchoconstriction, is a type of ... Patients with aspirin-induced asthma (AIA) should avoid aspirin and other NSAIDs, including ibuprofen (Advil and other brands, ...
... allowing an effective distinction between aspirin-induced asthma (AIA) and aspirin-tolerant asthma (ATA) are missing. ... METHODS: Patients experiencing symptoms following aspirin ingestion were considered as aspirin sensitive. Peripheral blood was ... suggesting a novel candidate gene and a potentially innovative pathway for mucosal inflammation in aspirin intolerance. ... aspirin is associated with nasal and bronchial inflammation, eliciting local symptoms. Although the disease is clinically well ...
... asthma; pulmonary physiology; asthma related clinical health; clinical immunology and the immunological basis of disease; ... Aspirin "Allergy"-Induced Thrombocytopenia: A Case Report Fu W, Xu S, Dong X, Xie Q, Gao Y ... The Effects of Asthma on the Association Between Pulmonary Function and Obesity: A 16-Year Longitudinal Study Huang YJ, Chu YC ... Phenotype-Guided Asthma Therapy: An Alternative Approach to Guidelines Pérez de Llano L, Dacal Rivas D, Blanco Cid N, Martin ...
Therapeutic Control of Aspirin-Exacerbated Respiratory Disease (Aspirin). *Asthma, Aspirin-Induced. *Aspirin Exacerbated Asthma ... The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases. *Asthma, Aspirin-Induced ... Therapeutic efficacy of high-dose aspirin as assessed by asthma symptom control (Asthma Control Questionnaire) ... Aspirin. August 2012. December 2016. March 2017. May 14, 2012. January 5, 2017. *Asthma Research Center. Boston, Massachusetts ...
Aspirin-induced asthma. *Drug allergy. *Hypereosinophilic syndrome. *Systemic mastocytosis. Interests. *Clinical management of ...
  • BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use. (umassmed.edu)
  • Exercise spirometry is the standard method for assessing patients with exercise-induced bronchoconstriction. (medscape.com)
  • Asthma is a disease of diffuse airway inflammation caused by a variety of triggering stimuli resulting in partially or completely reversible bronchoconstriction. (merckmanuals.com)
  • Aspirin-mediated inhibition of cyclooxygenase-promoted metabolism of arachidonic acid to prostaglandins which has the effect of increasing arachidonic acid conversion to leukotrienes, which are bronchoconstrictive, represents a possible mechanism of aspirin-induced bronchoconstriction. (pharmacology2000.com)
  • PURPOSE: Exercise-induced bronchoconstriction (EIB) in patients with asthma occurs more frequently in winter than in summer. (biomedsearch.com)
  • Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. (semanticscholar.org)
  • BACKGROUND Previous research has demonstrated that fish oil supplementation has a protective effect on exercise-induced bronchoconstriction (EIB) in elite athletes, which may be attributed to its antiinflammatory properties. (semanticscholar.org)
  • Vitamin D and omega-3 polyunsaturated fatty acid supplementation in athletes with exercise-induced bronchoconstriction: a pilot study. (semanticscholar.org)
  • Asthma treatment guidelines advocate the use of long-acting β2-agonists (LABA) in addition to inhaled corticosteroids (ICS) in patients whose asthma is uncontrolled by ICS alone, thereby addressing two processes fundamental to asthma: bronchoconstriction and inflammation. (eurekaselect.com)
  • Aspirin-induced asthma is a distinct clinical syndrome which affects about 10% of adult asthmatics. (ersjournals.com)
  • Daily high-dose aspirin therapy benefits many patients with aspirin-exacerbated respiratory disease but provides no benefit for aspirin-tolerant asthmatics. (bioportfolio.com)
  • Despite being treated with higher doses of inhaled corticosteroids (median dose 1773 µg) and for a third of the severe asthmatics also being treated with regular, oral-steroid therapy (median daily dose 19 mg), the subjects with severe asthma met the inclusion criteria. (ersjournals.com)
  • Females dominated the severe asthma group (female/male ratio 4.4:1 versus 1.6:1 in the controlled asthmatics), and compared with controlled asthmatics, they had a predominantly neutrophilic inflammation (sputum neutrophils, 36 versus 28%) and evidence of ongoing mediator release but less atopy. (ersjournals.com)
  • These more severe asthmatics, which account for ∼10% of the asthmatic population, have a disproportionate impact on healthcare utilisation, accounting for up to at least half of the direct and indirect costs for asthma 2 . (ersjournals.com)
  • Asthmatics whose disease is inadequately controlled have more extensive use of asthma medication. (ersjournals.com)
  • Bronchial hyperreactivity, on the other hand, although common to the vast majority of asthmatics, is not specific for bronchial asthma and provocation tests to measure bronchial hyperreactivity are not suited for routine monitoring of bronchial asthma. (springer.com)
  • Why don't asthmatics notice the connection between their asthma and foods? (fedup.com.au)
  • A few asthmatics will react to sulphites with an immediate asthma attack but for most asthmatics, sulphites will cause irritable airways with no obvious symptoms. (fedup.com.au)
  • In Australia, there are benzoates in asthma medication and other medications given to asthmatics, despite objections by doctors. (fedup.com.au)
  • METHODS: Ninety-four aspirin-induced urticaria patients presenting urticaria/angioedema-induced by both ASA and NSAID (50 had underlying chronic urticaria) and showing positive responses on oral aspirin challenge test, 76 aspirin-intolerant asthmatics with positive responses on lysine-aspirin bronchoprovocation test, and 185 normal healthy controls were enrolled. (biomedsearch.com)
  • According to Dr. Babu, chronic persistent inflammation is the hallmark of patients with aspirin-induced asthma. (newswise.com)
  • This distinct clinical syndrome, called aspirin-induced asthma (AIA), is characterized by a typical sequence of symptoms, intense eosinophilic inflammation of nasal and bronchial tissues, combined with overproduction of cysteinyl-leukotrienes (Cys-LTs). (nih.gov)
  • Aspirin-induced asthma refers to inflammation and constriction of the airways that is triggered by the use of aspirin. (rightdiagnosis.com)
  • The pathophysiology of asthma is complex and involves airway inflammation, intermittent airflow obstruction, and bronchial hyperresponsiveness. (medscape.com)
  • Antigen presentation by the dendritic cell with the lymphocyte and cytokine response leading to airway inflammation and asthma symptoms. (medscape.com)
  • The mechanism of inflammation in asthma may be acute, subacute, or chronic, and the presence of airway edema and mucus secretion also contributes to airflow obstruction and bronchial reactivity. (medscape.com)
  • Our results indicated that aspirin-induced asthma is associated with overproduction of LT with a shift to the 5-lipoxygenase series of the arachidonate cascade and that leukotriene receptor antagonist are useful for AIA through inhibition of production of LT and eosinophilic inflammation in the airway. (unboundmedicine.com)
  • BACKGROUND: In sensitive patients, aspirin is associated with nasal and bronchial inflammation, eliciting local symptoms. (archives-ouvertes.fr)
  • Employing two molecular biological methods, we demonstrate that galectin-10 mRNA is overexpressed in AIA, suggesting a novel candidate gene and a potentially innovative pathway for mucosal inflammation in aspirin intolerance. (archives-ouvertes.fr)
  • Mechanism of airway inflammation in asthma. (medscape.com)
  • Inflammation and asthma. (medscape.com)
  • Type 2 inflammation characterizes aspirin-e. (bioportfolio.com)
  • If a person with asthma takes ibuprofen as a painkiller, it can cause symptoms of asthma or inflammation of the inside of the nose. (medicalnewstoday.com)
  • Asthma is a chronic airway inflammation, characterized by variable airway obstruction and reduced lung function, and leading to wheezing and shortness of breath [1]. (scielo.cl)
  • risk of asthma increases in both children and adults who are overweight, due to increased bodily inflammation, and obesity rates have risen. (mountainside-medical.com)
  • Asthma is not just obstruction of the airway, but also inflammation. (mountainside-medical.com)
  • Variety of risk factors and nonatopic nature of adult-onset disease suggest that variety of mechanisms is involved in the disease pathogenesis and that these mechanisms differ from the pathobiology of childhood-onset asthma with prevailing Th2 airway inflammation. (hindawi.com)
  • Patients with early-onset asthma are typically atopic with family history of atopy or asthma, Th2-predominant inflammation, good responsiveness to glucocorticoids, and good prognosis [ 1 , 2 ]. (hindawi.com)
  • 1 On the other hand, asthma is a chronic inflammation of the lower airways involving episodic breathlessness and wheezing, with airway hyperresponsiveness to environmental stimuli, with a prevalence of 5%-10% in the general population. (dovepress.com)
  • CRSwNP and asthma frequently coexist, 1 both conditions sharing similar features of inflammation and remodeling. (dovepress.com)
  • Tremendous progress has been made in our fundamental understanding of asthma pathogenesis by virtue of invasive research tools such as bronchoscopy, bronchoalveolar lavage, airway biopsy, and measurement of airway gases, although the cause of airway inflammation remains obscure. (clevelandclinicmeded.com)
  • Heterogeneity in the pattern of asthma inflammation has been recognized, consistent with the interpretation that phenotypic differences exist that influence treatment response. (clevelandclinicmeded.com)
  • The inflammation of asthma leads to an associated increase in the existing bronchial hyperresponsiveness to a variety of stimuli.Although the absolute minimum criteria to establish a diagnosis of asthma are not widely agreed on, the presence of airway hyper-reactivity can be regarded as a sine qua non for patients with current symptoms and active asthma. (clevelandclinicmeded.com)
  • This designation is for asthma (increased airway resistance) caused by acute inflammation due to pathogens, such as viruses, bacteria, or mycoplasma. (pharmacology2000.com)
  • The clinical features of asthma are related to cellular as well as to soluble parameters of bronchial inflammation. (springer.com)
  • Since eosinophils, T lymphocytes, mast cells, macrophages, neutrophils, epithelial cells, and structural cells, as well as various proinflammatory mediators and proteins, have been implicated in the pathogenesis of bronchial asthma, it has been anticipated that several of these cells or mediators might be either diagnostic of bronchial asthma or could serve as markers to monitor the underlying bronchial inflammation. (springer.com)
  • Therefore, T-lymphocyte activation, and especially assessment of systemic and local IL-5 levels, might be of diagnostic value and possibly useful in monitoring of inflammation in bronchial asthma in the future. (springer.com)
  • A possible role and future applications for other markers of inflammation not related to eosinophils in monitoring or diagnosing bronchial asthma need to be established. (springer.com)
  • Asthma causes swelling and inflammation in the airways that lead to your lungs. (northshore.org)
  • Asthma is a chronic disease that involves inflammation of the lungs. (stlukes-stl.com)
  • Asthma is a disease of chronic inflammation, and it is known that transgenic mice born without TBX21 spontaneously develop abnormal lung function consistent with asthma. (wikipedia.org)
  • Airway hyperresponsiveness or bronchial hyperreactivity in asthma is an exaggerated response to numerous exogenous and endogenous stimuli. (medscape.com)
  • Pranlukast inhibited the bronchial reaction and an increase in sputum ECP after threshold dosed of ASA, but failed to change aspirin-induced LT production in sputum and urine. (unboundmedicine.com)
  • Cyclo-oxygenase inhibition may not be a pathogenic mechanism of acetaminophen-induced bronchial asthma. (ajou.ac.kr)
  • Bronchial thermoplasty is a relatively new treatment for severe persistent adult asthma. (limamemorial.org)
  • These findings suggest that selective manipulation of the prostanoid receptors may be beneficial in treatment of allergic diseases, such as bronchial asthma, allergic rhinitis and conjunctivitis. (nii.ac.jp)
  • Asthma is an inflammatory disorder of the airways associated with airflow obstruction and bronchial hyperresponsiveness that varies in severity across the spectrum of the disease. (ersjournals.com)
  • Asthma symptoms in children often show up before age 5, but this can be difficult for even doctors to recognize due to the small bronchial tubes infants and very young children possess. (mountainside-medical.com)
  • Bronchial asthma is more prevalent in patients who suffer chronic rhinosinusitis, while asthmatic patients have a greater prevalence of CRSwNP than patients without asthma. (dovepress.com)
  • Although much progress has been made in our understanding of bronchial asthma in recent years, asthma remains a commonly encountered condition that challenges physicians in the office setting as well as in acute care settings. (clevelandclinicmeded.com)
  • Intrinsic bronchial hyperactivity can be triggered by infection, exercise, or drugs such as aspirin. (hon.ch)
  • Based on a growing body of evidence, allergic as well as intrinsic bronchial asthma have recently been defined as chronic persistent inflammatory disorders. (springer.com)
  • Agreement has been reached that asthma can no longer be equated with bronchospasm only, and that the absence of reversibility of airflow obstruction does not exclude bronchial asthma. (springer.com)
  • Currently there is no diagnostic marker of bronchial asthma, which, on its own, either confirms or excludes bronchial asthma with appropriate sensitivity and specificity. (springer.com)
  • Clinically the most reliable feature of bronchial asthma that seems to be related closely to the symptomatology still is the presence of eosinophils in peripheral blood, and especially in sputum. (springer.com)
  • Eosinophil-derived products, particularly eosinophil granule proteins, have been investigated as markers of eosinophil participation in the pathogenesis of asthma and, comparable to eosinophil numbers themselves, are possible predictors of impending exacerbations of allergic, as well as intrinsic bronchial asthma. (springer.com)
  • However, clinically their precise value in diagnosing and monitoring of bronchial asthma has not been documented convincingly and requires further investigation. (springer.com)
  • Journal Article] TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma. (nii.ac.jp)
  • METHODS: The medical records of 74 young adult male patients with asthma-like symptoms who underwent bronchial challenge with methacholine, 4.5% saline and exercise, and allergen skin prick tests, were reviewed. (biomedsearch.com)
  • Bronchial Asthma. (slideserve.com)
  • BACKGROUND AND OBJECTIVE: The natural killer (NK) cells which play an important role in defense immune system are supposed to be involved in the pathogenesis of bronchial asthma. (koreamed.org)
  • Six centuries later, Galen wrote much about asthma, noting that it was caused by partial or complete bronchial obstruction. (bionity.com)
  • Allergic diseases such as bronchial asthma and atopic dermatitis develop by a combination of genetic and environmental factors. (koreamed.org)
  • Writing in the monthly peer-reviewed journal of the American College of Chest Physicians, K. Suresh Babu, M.D., D.N.B., along with another colleague from the Department of Cellular and Molecular Biology, University of Southampton, Southampton General Hospital, Southampton, United Kingdom, said that attacks of aspirin-induced asthma are often precipitated by ingesting small amounts of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDS). (newswise.com)
  • In some patients with asthma, aspirin (ASA) and all nonsteroidal anti-inflammatory drugs that inhibit cyclooxygenase enzymes (cyclooxygenase-1 and -2) precipitate asthmatic attacks and naso-ocular reactions. (nih.gov)
  • Aspirin-induced asthma is asthma triggered by taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). (foresthillspediatrics.com)
  • The study, which included in-person interviews, included 1,442 breast cancer cases and 1,420 controls.Results show that use of aspirin and other nonsteroidal anti-inflammatory drugs at least once per week for six months produced a 20-percent lower risk of breast cancer as compared to nonusers. (bio-medicine.org)
  • Aspirin and nonsteroidal anti-inflammatory drugs can raise the risk of asthma in some people who also have rhinitis and sinusitis. (epnet.com)
  • In contrast, atopy may be less important in patients with adult asthma and other factors such as intolerance to aspirin and related nonsteroidal anti-inflammatory drugs (NSAIDs) as well as occupational exposures have been suggested to play an important role in adults with more severe asthma 1 , 8 . (ersjournals.com)
  • Aspirin along with many nonsteroidal anti-inflammatory drugs can induce bronchospasm in up to 20% of adult asthma patients. (pharmacology2000.com)
  • The chest radiograph remains the initial imaging evaluation in most individuals with symptoms of asthma, but in most patients with asthma, chest radiography findings are normal or may indicate hyperinflation. (medscape.com)
  • Furthermore, studies have shown that leukotrienes are produced in excessive quantities in patients with asthma, reinforcing the view that they are important biological mediators. (bmj.com)
  • The triad of asthma, aspirin sensitivity, and nasal polyps affects 5-10% of patients with asthma. (medscape.com)
  • To this extent, there has been much emphasis on early diagnosis and longitudinal care of patients with asthma, along with ensuring adherence to recommended therapies. (clevelandclinicmeded.com)
  • Although patients appear to recover completely clinically, evidence suggests that patients with asthma develop chronic airflow limitations. (medscape.com)
  • This study examined the relationship between seasonal differences in the prevalence of EIB and sensitization to HDMs in patients with asthma. (biomedsearch.com)
  • PURPOSE: The objective of this study was to evaluate skills in handling inhalers and factors associated with these skills among patients with asthma who had undergone treatment at special asthma. (koreamed.org)
  • An ICS/LABA combination in a single inhaler represent safe, effective and convenient treatment options for the management of patients with asthma and COPD. (eurekaselect.com)
  • Fifty percent of the patients who have aspirin-induced asthma have chronic, severe, corticosteroid-dependent asthma," said Dr. Babu. (newswise.com)
  • Asthma is a long-lasting (chronic) lung disease. (foresthillspediatrics.com)
  • Asthma is a common chronic disease worldwide and affects approximately 26 million persons in the United States. (medscape.com)
  • Asthma is among the leading causes of hospitalization in children and is the number one chronic condition causing elementary school absenteeism. (merckmanuals.com)
  • Treating co-existing chronic conditions (such as rhinitis, sinusitis, and obesity) can also help improve asthma control. (limamemorial.org)
  • Asthma is a chronic condition in which the airways undergo changes that are usually triggered by allergens, other environmental factors, or by infection. (limamemorial.org)
  • Bronchospasms can result from many different health conditions (allergies, bronchitis, and chronic obstructive pulmonary disease) but asthma is the most common cause. (limamemorial.org)
  • In this article I provide a brief overview of evidence supporting their use in patients with chronic asthma, focusing on two leukotriene receptor antagonists, montelukast and zafirlukast, currently licensed for use in the United Kingdom. (bmj.com)
  • A link between chronic asthma and chronic infection. (medscape.com)
  • 1st-line therapy for chronic asthma. (studystack.com)
  • Chronic asthma in children. (epnet.com)
  • Aspirin Exacerbated Respiratory Disease (AERD) is a chronic inflammatory disease involving nose, sinuses, and lungs. (medindia.net)
  • Asthma is one of the most common chronic diseases in the world. (mountainside-medical.com)
  • Asthma is the number one chronic disease for children. (mountainside-medical.com)
  • Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have coexisting asthma under the concept of "United Airway Disease", being the combination of both diseases, which is one of the most challenging phenotypes to treat. (dovepress.com)
  • There is increasing epidemiological evidence linking chronic rhinosinusitis and asthma, but a good understanding of the pathophysiology and the combined management is still lacking. (dovepress.com)
  • Asthma is a chronic, episodic disease of the airways that is best viewed as a syndrome. (clevelandclinicmeded.com)
  • Asthma is a chronic disorder with recurrent attacks of wheezing, shortness of breath and cough. (rxmed.com)
  • Asthma is a chronic inflammatory disease of the airways that is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli. (medscape.com)
  • Asthma as a chronic illness and as a co-existing disease in the anesthesia setting. (pharmacology2000.com)
  • High consumers of highly sulphited foods are particularly at risk or asthma or chronic cough. (fedup.com.au)
  • BACKGROUND AND OBJECTIVE: Asthma is the most common chronic disease among children. (koreamed.org)
  • Asthma is a chronic condition involving the respiratory system in which the airway occasionally constricts, becomes inflamed , and is lined with excessive amounts of mucus , often in response to one or more triggers. (bionity.com)
  • In some individuals asthma is characterized by chronic respiratory impairment. (bionity.com)
  • Asthma is the most common chronic childhood illness. (stlukes-stl.com)
  • Since asthma is an inflammatory condition of the airways, exposure to aspirin or NSAIDS in certain individuals appears temporarily to accentuate the inflammatory process, leading to asthma exacerbations. (newswise.com)
  • 1 For people with this type of asthma, taking aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) triggers an asthma attack. (asthma.net)
  • 2 NSAIDs include naproxen (ex: Aleve) and ibuprofen (ex: Advil, Motrin), as well as aspirin. (asthma.net)
  • The Table contains list of prescription and non-prescription NSAIDs that may cause an asthma attack in people with aspirin-induced asthma. (asthma.net)
  • Several medicines contain aspirin or other NSAIDs. (foresthillspediatrics.com)
  • Aspirin, ibuprofen, and naproxen are NSAIDs. (foresthillspediatrics.com)
  • Symptoms start 1 to 3 hours after taking aspirin or NSAIDs. (foresthillspediatrics.com)
  • The asthma attack triggered by aspirin and NSAIDs can be life threatening. (foresthillspediatrics.com)
  • They may have taken aspirin or NSAIDS in the past without any side effects. (foresthillspediatrics.com)
  • There are no blood tests or skin tests that will diagnose allergy to aspirin or NSAIDs. (foresthillspediatrics.com)
  • Aspirin-induced asthma is another recognized condition, which is believed can occur with the use of other NSAIDs as well. (medicalnewstoday.com)
  • It also involves a newly-formed sensitivity to aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs). (medindia.net)
  • Aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) can trigger asthma in up to 5% of adult asthma patients. (stlukes-stl.com)
  • Platelets and Aspirin-Induced Asthma: Pathogenesis and Melatonin Edition by Evsyukova, Helen and Publisher Academic Press. (vitalsource.com)
  • Pathogenesis of asthma. (medscape.com)
  • filming the first whatever download platelets and aspirin induced asthma pathogenesis and variety against sudden best guides: an self student. (kehrdichannichts.de)
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  • The aim of this review was to summarize the current knowledge on the pathogenesis of adult-onset asthma and to concentrate on the mechanisms and mediators involved in establishing adult-onset asthma in response to specific risk factors. (hindawi.com)
  • This review aims to summarize the current knowledge on the pathogenesis of adult-onset asthma, concentrating on the known risk factors and on the mechanisms of how these factors might be involved in establishing asthma. (hindawi.com)
  • This review of asthma for the practicing clinician summarizes these developments, including an update on the definition of asthma, its epidemiology, natural history, cause, and pathogenesis. (clevelandclinicmeded.com)
  • PURPOSE: Chlamydophila pneumoniae infection in the airways is thought to be associated with the pathogenesis of asthma, especially in non-atopic severe asthma with irreversible airway obstruction that may be related. (koreamed.org)
  • Hypersensitivity reactions to acetami- nophen are rare and selective sensitivity to acetaminophen without aspirin or non-steroidal antiinflammatory drug intolerance is even rarer. (ajou.ac.kr)
  • In these patients aspirin and several other analgesics precipitate asthmatic attacks. (ersjournals.com)
  • Their major assumption is that inhibition of cyclooxygenase triggers specific biochemical reactions which lead to open asthma attacks. (ersjournals.com)
  • These medicines are used as needed to treat asthma attacks. (foresthillspediatrics.com)
  • To prevent asthma attacks, your child may need a different type of medicine called a controller. (foresthillspediatrics.com)
  • They do not provide quick relief of wheezing in acute asthma attacks. (foresthillspediatrics.com)
  • Short-term risks that may occur during the procedure include increased or worsening asthma attacks. (limamemorial.org)
  • The asthma attacks that are triggered by aspirin can be life-threatening, so prompt medical attention is very important if you suffer an attack. (acnearticle.info)
  • Those who do have a reaction to ibuprofen can find that it makes asthma attacks more severe and harder to control. (medicalnewstoday.com)
  • Hreib said he would recommend aspirin as a migraine treatment for anyone with mild to moderate migraine symptoms who has attacks about one to three times per month. (everydayhealth.com)
  • This results in fewer future surgeries, less need for prednisone and antibiotics, and fewer asthma attacks. (medindia.net)
  • Treating asthma is a matter of determining what triggers asthma attacks or episodes and adjusting your lifestyle to prevent exposing yourself to these triggers. (mountainside-medical.com)
  • Over 11.5 million people, 3 million of them children, report having asthma episodes or attacks in a calendar year. (mountainside-medical.com)
  • Asthma attacks vary in frequency and severity. (rxmed.com)
  • Most asthma attacks prove to be short-lived, lasting minutes to hours. (medscape.com)
  • Increased production and excretion of LTE4 has been linked to several respiratory diseases, and urinary LTE4 levels are increased during severe asthma attacks and are especially high in people with aspirin-induced asthma, also known as Samter's Triad or aspirin-exacerbated respiratory disease (AERD). (wikipedia.org)
  • Some people have asthma attacks only during allergy season, or when they breathe in cold air, or when they exercise. (northshore.org)
  • Even if you have few asthma attacks, you still need to treat your asthma. (northshore.org)
  • Severe asthma attacks can be life-threatening and need emergency treatment. (northshore.org)
  • Asthma attacks can be life-threatening, but you may be able to prevent them if you follow a plan. (northshore.org)
  • How can you prevent asthma attacks? (northshore.org)
  • You can prevent some asthma attacks by avoiding those things that cause them. (northshore.org)
  • Researchers at Johns Hopkins University and Geisinger Health Systems have teamed up again to release another study of the potential impacts of oil and gas development in the Marcellus, this time focusing on exacerbations of asthma attacks. (energyindepth.org)
  • This new study claims those who live near shale gas wells are "1.5 to four times likelier to have asthma attacks than those who live far away. (energyindepth.org)
  • As the researchers likely intended, the study produced provocative headlines like "Health study shows connection between asthma attacks and gas drilling" even though it actually doesn't show that and the authors openly admit that. (energyindepth.org)
  • The clinical syndrome of aspirin-exacerbated respiratory disease (AERD) is a condition where inhibition of cyclooxygenase-1 (COX-1) induces attacks of upper and lower airway reactions, including rhinorrhea and varying degrees of. (koreamed.org)
  • During very severe attacks, an asthma sufferer can turn blue from lack of oxygen, and can experience chest pain or even loss of consciousness. (bionity.com)
  • Asthma attacks can last minutes to days, and can become dangerous if airflow to the lungs becomes severely restricted. (stlukes-stl.com)
  • If patients discontinue aspirin for some days, then their sensitivity to the drug could return to its previous levels, and that could precipitate an acute asthma attack if they are exposed to the drug. (newswise.com)
  • I have Samter's Syndrome (consisting of asthma, aspirin sensitivity and nasal polyps) also known as Samter's Triad or aspirin-induced asthma. (fedup.com.au)
  • What is the triad of asthma, aspirin sensitivity, and nasal polyps? (medscape.com)
  • Aspirin also reduced other migraine symptoms like nausea and sensitivity to noise and light. (everydayhealth.com)
  • In aspirin desensitization allergists give gradually increasing doses of aspirin to reduce aspirin sensitivity. (medindia.net)
  • Aspirin desensitization , a therapy where an allergist gives a patient, gradually-increasing doses of aspirin to help the patient overcome the sensitivity, may reduce the symptoms of Aspirin Exacerbated Respiratory Disease (AERD) heightened by exposure to alcohol , research at the University of Pennsylvania School of Medicine finds. (medindia.net)
  • A common approach to this problem involves aspirin desensitization, in which an allergist gives a patient gradually-increasing doses of aspirin to help the patient overcome the sensitivity. (medindia.net)
  • Sensitivity analyses assessed model performance for outcomes related to asthma up to age 20 years. (uni-wuerzburg.de)
  • Spirometry with postbronchodilator response should be obtained as the primary test to establish the asthma diagnosis. (medscape.com)
  • Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. (medscape.com)
  • Diagnosis and management of work-related asthma: American College Of Chest Physicians Consensus Statement. (medscape.com)
  • Patients were included in the analysis if they were admitted for ACS (unstable angina, NSEMI, STEMI), had self-reported aspirin allergy, and did not receive aspirin for initial management of ACS but did receive a P2Y12 inhibitor within the first 24 hours of ACS diagnosis. (physiciansweekly.com)
  • Utility of low-dose oral aspirin challenges for diagnosis of aspirin-exacerbated respiratory disease. (nextbio.com)
  • One woman noticed that her diagnosis of adult-onset asthma coincided with a switch to diet cola. (fedup.com.au)
  • The diagnosis and management of asthma in young children is difficult, since there are many different wheezy phenotypes with varying underlying aetiologies and outcomes. (koreamed.org)
  • 6 Aspirin-induced asthma is also called aspirin-exacerbated respiratory disease or AERD. (asthma.net)
  • Aspirin desensitization treatment for the management of aspirin-exacerbated respiratory disease. (medscape.com)
  • Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-Exacerbated Respiratory Disease: A Prospective Trial. (bioportfolio.com)
  • Endoscopic sinus surgery improves aspirin treatment response in aspirin-exacerbated respiratory disease patients. (bioportfolio.com)
  • Aspirin desensitization and treatment benefits most patients with aspirin-exacerbated respiratory disease (AERD), although some patients fail therapy. (bioportfolio.com)
  • The Asthma Program at the Mount Sinai National Jewish Health Respiratory Institute is committed to providing personalized, comprehensive management of asthma by incorporating the latest research and advanced treatments. (mountsinai.org)
  • Aspirin desensitization may reduce symptoms of Aspirin Exacerbated Respiratory Disease (AERD) worsened by alcohol. (medindia.net)
  • When the symptoms of Aspirin Exacerbated Respiratory Disease (AERD) are worsened after drinking alcohol, aspirin desensitization may help reduce the allergic reaction. (medindia.net)
  • children who have issues with respiratory infection are at increased risk of developing asthma. (mountainside-medical.com)
  • Genetic factors, atopy, and early respiratory tract infections are well-recognized factors predisposing to childhood-onset asthma. (hindawi.com)
  • Adult-onset asthma is more often associated with obesity, smoking, depression, or other life-style or environmental factors, even though genetic factors and respiratory tract infections may also play a role in adult-onset disease. (hindawi.com)
  • Factors predisposing to adult-onset asthma include female sex, obesity, occupational exposure, rhinitis, respiratory infections, smoking, stressful life events, and low level of lung function [ 10 - 13 ] suggesting that adult-onset asthma may develop through a variety of mechanisms. (hindawi.com)
  • Background: A novel non-invasive asthma prediction tool from the Leicester Cohort, UK, forecasts asthma at age 8 years based on 10 predictors assessed in early childhood, including current respiratory symptoms, eczema, and parental history of asthma. (uni-wuerzburg.de)
  • WDR46 is a Genetic Risk Factor for Aspirin-Exacerbated Respiratory Disease in a Korean Population. (biomedsearch.com)
  • Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial. (semanticscholar.org)
  • [ 12 ] However, no clinical studies have directly linked asthma symptoms with acetaminophen use. (medscape.com)
  • Several clinical trials reported that clopidogrel was superior to aspirin in secondary stroke prevention by reducing the risk of major adverse cardiovascular events (MACE). (bioportfolio.com)
  • Our study suggests that there may be a brief window of time during which the treating cardiologist and allergist can attempt clinical stabilization of acute coronary syndrome patients prior to performing aspirin desensitization without an adverse effect on short-term cardiac outcomes," Nguyen said. (physiciansweekly.com)
  • The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma. (ingentaconnect.com)
  • Because asthma is a heterogeneous disorder with a variety of underlying mechanisms and clinical presentations, not all medications work the same for all patients. (mountsinai.org)
  • In Portugal, 7.83% of the population is affected by clinical asthma and 8.72% by wheezing symptoms [5]. (scielo.cl)
  • AERD can severely affect a patient's quality of life, and when you combine the findings of this study with the clinical outcomes we can achieve, it shows aspirin desensitization can considerably improve quality of life for those who undergo it," Bosso said. (medindia.net)
  • Since severe asthma is a poorly understood, major health problem, 12 clinical specialist centres in nine European countries formed a European Network For Understanding Mechanisms Of Severe Asthma (ENFUMOSA). (ersjournals.com)
  • From these findings and other physiological and clinical data reported in this paper, it is suggested that severe asthma might be a different form of asthma rather than an increase in asthma symptoms. (ersjournals.com)
  • Further randomized clinical trials are, however, still needed to better understand the management when both asthma and CRSwNP occur together. (dovepress.com)
  • Since the introduction of the "United Airway Disease" concept, 4 a large body of evidence from clinical epidemiology, pathophysiology, histology, and treatment outcomes has correlated asthma and CRSwNP. (dovepress.com)
  • This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies. (routledge.com)
  • Conclusion: The novel asthma prediction tool from the Leicester cohort, UK, performed well in another population, a German birth cohort, supporting its use and further development as a simple aid to predict asthma risk in clinical settings. (uni-wuerzburg.de)
  • Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice. (semanticscholar.org)
  • PURPOSE: Live Mycobacterium bovis Bacille Calmette-Guerin (BCG) has a suppressive effect on asthma, but its use in clinical practice may be limited due to adverse reactions. (koreamed.org)
  • These effects may contribute to the improved efficacy seen when treating asthma and COPD with ICS/LABA combinations in clinical studies. (eurekaselect.com)
  • Clinical results also suggest that adjustable dosing with budesonide/formoterol provides better asthma control than fixed dosing. (eurekaselect.com)
  • The rate of protocol-defined asthma exacerbations, normalized by subject-time at risk and computed over the 24 week treatment period in each treatment group. (clinicaltrials.gov)
  • The number of patients reporting one or more protocol-defined asthma exacerbations during the 24 week treatment period. (clinicaltrials.gov)
  • Prevent asthma exacerbations. (rxmed.com)
  • 1 As noted before, between acute exacerbations there may be limited symptoms associated with asthma. (pharmacology2000.com)
  • Baigelman W, Chodosh S, Pizzuto D, Cupples A (1983) Sputum and blood cosinophilia during corticosteroid treatment of acute exacerbations of asthma. (springer.com)
  • Psychosocial stress, exposure to air pollution, including from truck traffic, sleep disruption, and reduced socioeconomic status are all biologically plausible pathways for UNGD to affect asthma exacerbations. (energyindepth.org)
  • By comparing the electronic health records of 35,508 asthma patients "with and without exacerbations" treated at Geisinger Clinic between 2005 and 2012, the authors claim to have identified 20,749 mild asthma exacerbation instances (new oral corticosteroid medication order), 1,870 moderate (emergency department visit) and 4,782 severe (hospitalization) asthma exacerbations that they claim show an "association" to residential proximity to natural gas development. (energyindepth.org)
  • Residential UNGD activity metrics were statistically associated with increased risk of mild, moderate, and severe asthma exacerbations. (energyindepth.org)
  • One would think that if you were going to study whether fracking contributed to asthma exacerbations you could want to compare patients with exacerbations in counties with shale development to patients with exacerbations in counties without shale development. (energyindepth.org)
  • Superior control - including a reduction in severe exacerbations - of asthma and COPD by ICS/LABA combination therapy has been demonstrated. (eurekaselect.com)
  • In AIA, aspirin induced an immediate reaction associated with increased urinary LTE4/Cr and sputum ECP and a fall in urinary 11-dhTXB2/Cr. (unboundmedicine.com)
  • Some small studies of severe asthma, using induced sputum toassess the airway inflammatory response, have shown thatdespite the regular use of high-dose inhaled and oral corticosteroids, eosinophilia persists. (ersjournals.com)
  • Cough associated with asthma can be nonproductive or associated with significant sputum. (pharmacology2000.com)
  • A subset of persons with asthma develop bronchospasm, naso-ocular, gastrointestinal, and/or dermal reactions after ingesting aspirin (ASA) or agents with the capacity to inhibit cyclooxygenase. (nih.gov)
  • Ibuprofen can also worsen asthma symptoms by causing the airways to narrow in a condition known as bronchospasm. (medicalnewstoday.com)
  • however, the protective effects of long-term LTRA administration against aspirin-induced bronchospasm have not been evaluated. (koreamed.org)
  • For patient download platelets and aspirin induced asthma of plenty it calls new to consolidate Job. (kehrdichannichts.de)
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  • Your child starts by taking a very small dose of aspirin in a medical setting where there is emergency support. (foresthillspediatrics.com)
  • The dose is carefully and gradually increased until a normal dose of aspirin can be taken without causing symptoms. (foresthillspediatrics.com)
  • As the dose is increased, there is a chance of a sudden asthma attack. (foresthillspediatrics.com)
  • Once your child is able to take a normal dose of aspirin without having symptoms, your child will keep taking that dose every day. (foresthillspediatrics.com)
  • This led to interest in the development of specific leukotriene modifying asthma drugs, which might confer additional benefits even in patients already receiving an optimal dose of inhaled corticosteroid. (bmj.com)
  • A single dose can provoke an acute asthma exacerbation, accompanied by rhinorrhea, conjunctival irritation, and flushing of the head and neck. (medscape.com)
  • The objective of this pilot study is to evaluate the prevalence of biological aspirin resistance in women at risk for CHD taking low dose (81 mg) aspirin. (bioportfolio.com)
  • Diabetes and Platelet Response to Low-dose Aspirin. (bioportfolio.com)
  • Our first hypothesis is that dose adjustment of aspirin and clopidogrel based on biological monitoring reduces the rate of severe cardiovascular complications compared to a conventional st. (bioportfolio.com)
  • This study will explore the effect of different doses of aspirin on the effects of double-dose or standard dose clopidogrel. (bioportfolio.com)
  • Three patients challenged with high dose aspirin experienced urticaria/angioedema and 1 experienced anaphylaxis at a cumulative dose of 570 mg. (physiciansweekly.com)
  • Will a High Dose of Aspirin Relieve Your Migraine? (everydayhealth.com)
  • Combining high-dose aspirin with the anti-nausea drug metoclopramide (Reglan) was better for reducing nausea than aspirin alone. (everydayhealth.com)
  • Patients in these studies took a single dose of aspirin in the range of 900 to 1000 milligrams, which is equal to three adult-strength aspirins, a safe dose for most people. (everydayhealth.com)
  • A protocol-defined asthma exacerbation was a worsening of asthma requiring treatment with oral or intravenous corticosteroid burst and/or a doubling of the baseline inhaled corticosteroids (ICS) dose for at least 3 days. (clinicaltrials.gov)
  • In a cross-sectional observational study, a total of 163 subjects with severe asthma were compared with 158 subjects whose asthma was controlled by low doses of inhaled corticosteroids (median dose of beclomethasone equivalents 666 µg). (ersjournals.com)
  • Adult-onset asthma is characterized by absence of atopy and is often severe requiring treatment with high dose of inhaled and/or oral steroids. (hindawi.com)
  • do they still have a place in patients who need low-dose aspirin for its antiplatelet effect? (mja.com.au)
  • Role of sulfite additives in wine induced asthma: single dose and cumulative dose studies. (wines.com)
  • Low dose aspirin as. (bmj.com)
  • Objective To determine the effect of low dose aspirin on ulcer healing in patients with venous leg ulcers. (bmj.com)
  • Conclusion Our findings do not support the use of low dose aspirin as adjuvant treatment for venous leg ulcers. (bmj.com)
  • Asthma symptoms are caused by two different problems in the airways. (foresthillspediatrics.com)
  • This non-drug procedure uses heat to shrink muscles in the airways that can enlarge during an asthma attack. (limamemorial.org)
  • They have been approved for use in patients with severe eosinophilic asthma, which is a type of asthma with increased levels of eosinophils (a type of white blood cell) found in the airways. (limamemorial.org)
  • asthma breathe in and out deeply, the airways relax and open to rid the lungs of the irritant. (limamemorial.org)
  • asthma try to exhale, their airways do not relax and narrow, causing hyperinflation of the lungs with unexpelled air. (limamemorial.org)
  • As asthma worsens, less air is able to get to the alveoli and the airways narrow further, causing patients to pant for breath. (limamemorial.org)
  • Smooth muscles in the airways of people with asthma may have a defect, perhaps a deficiency in a critical chemical that prevents the muscles from relaxing. (limamemorial.org)
  • And, during an asthma attack the airways narrow, making breathing difficult. (limamemorial.org)
  • In an acute asthma attack, wheezing will probably be most prominent, reflecting turbulent airflow through narrowed airways. (pharmacology2000.com)
  • When asthma flares up, the airways tighten and become narrower. (northshore.org)
  • But with asthma, muscles in the airways tighten, and the lining of the air passages swells. (stlukes-stl.com)
  • Over the long-term, noted Dr. Babu, persons with this problem should be advised to avoid aspirin and products containing aspirin. (newswise.com)
  • Avoidance of triggers - Aspirin, NSAID's and foods and medications containing salicylates may trigger symptoms in this group of patients. (rightdiagnosis.com)
  • The prognosis varies depending on how well exposure to triggers can be controlled and whether other asthma preventative measures are utilized e.g. preventative medications. (rightdiagnosis.com)
  • Control of Environmental Factors and Other Asthma Triggers. (limamemorial.org)
  • All children, whether they have asthma or not, should avoid taking aspirin , as it is thought the drug triggers a condition called Reye's syndrome. (medicalnewstoday.com)
  • If you avoid the sulphites - and other irritating food chemicals - that person can be exposed to asthma triggers without developing asthma. (fedup.com.au)
  • Asthma is a lung disease that causes coughing, wheezing, and shortness of breath. (foresthillspediatrics.com)
  • These actions in the airway cause coughing, wheezing, and shortness of breath (dyspnea), the classic symptoms of asthma. (limamemorial.org)
  • Ibuprofen and other painkillers may worsen the symptoms of asthma, such as shortness of breath. (medicalnewstoday.com)
  • If a person with asthma has an allergic reaction to ibuprofen or another medicine, it can often cause wheezing or shortness of breath. (medicalnewstoday.com)
  • The first symptoms of aspirin-induced asthma may include sneezing, a runny or stuffy nose, and redness and warmth of the face. (foresthillspediatrics.com)
  • Both oral provocation test with 500mg of aspirin and lysine-aspirin bronchoprovocation test showed negative results. (ajou.ac.kr)
  • Mast cell phenotype, location, and activation in severe asthma: data from the severe asthma research program. (medscape.com)
  • Even though majority of asthma is thought to be developed during childhood, this has been challenged recently by showing that, in the United States, adult-onset asthma is the dominant phenotype in women from 40 years of age [ 9 ]. (hindawi.com)
  • CONCLUSION: These findings suggest that the HLA-DRB1(*)1302-DQB1(*)0609-DPB1(*)0201 may be a strong genetic marker to determine the aspirin-induced urticaria phenotype. (biomedsearch.com)
  • The prevalence of asthma has increased continuously since the 1970s, and the WHO estimates that 235 million people worldwide are affected. (merckmanuals.com)
  • While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. (scielo.cl)
  • Given the high prevalence of asthma in the Madeira population [6], determining the population's genetic background is an essential first step towards understanding the mechanisms of the disease. (scielo.cl)
  • Racial factors come into play in asthma rates in the U.S. Puerto Ricans have the highest prevalence of asthma, while African-Americans have the highest prevalence of childhood asthma. (mountainside-medical.com)
  • Increases in prevalence of asthma in New Guinea when adult exposed to house dust mite. (powershow.com)
  • PURPOSE: To investigate the prevalence of asthma and determine its risk factors in elementary school students in Seoul. (koreamed.org)
  • Of particular importance in the patient with asthma are leukotrienes C 4 , D 4 , and E 4 . (bmj.com)
  • Cysteinyl leukotrienes are important biological mediators in asthma, interacting with at least one specific receptor in the lungs, which has now been fully identified, 6 , 7 leading to various important biological effects (box 1). (bmj.com)
  • 8 Thus leukotrienes are capable of inducing several key features of asthma. (bmj.com)
  • Henderson WR Jr. Role of leukotrienes in asthma. (medscape.com)
  • BACKGROUND AND OBJECTIVE: Many chemical mediators such as histamine, prostaglandins, leukotrienes, bradykinin, angiotensisn II (A II), and even angiotensin converting enzyme (ACE) affect the pathophysiology of asthma. (koreamed.org)
  • Your allergist may prescribe medications to help keep your asthma under control, such as inhaled corticosteroids. (acnearticle.info)
  • These subjects were 12-75 years old with atopic asthma, had elevated serum total Immunoglobulin E (IgE), had a baseline forced expiratory volume in 1 second (FEV1) ≥ 80% predicted, and were on inhaled corticosteroids with or without other controller asthma medications (e.g., long-acting β2-agonists [LABAs], leukotriene receptor antagonist [LTRA], or immunotherapy). (clinicaltrials.gov)
  • Patients with more severe disease are increasingly likely to have impaired lung function as studies have shown that despite the use of high doses of inhaled and oral corticosteroids, severe asthma is associated with a component of airflow obstruction that appears either nonreversible or at best difficult to reverse 1 , 6 . (ersjournals.com)
  • Advances in Asthma and COPD Treatment: Combination Therapy with Inhaled Corticosteroids and Long-Acting β2-Agonists. (eurekaselect.com)
  • Although the precise mechanism of aspirin desensitization is unclear, Dr. Babu noted that, to desensitize, patients should take small incremental doses of aspirin over two to three days, under a doctor's supervision, until they can tolerate 400 to 650 mg of aspirin. (newswise.com)
  • A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. (bioportfolio.com)
  • These side effects might come into play if large and frequent doses of aspirin are used to treat migraine. (everydayhealth.com)
  • For people with aspirin-induced asthma, the polyps usually grow back soon after surgery. (asthma.net)
  • In many cases, people with aspirin-induced asthma also have nasal polyps (growths in the lining of the nose or sinuses), long-term sinus disease, and loss of the sense of smell. (foresthillspediatrics.com)
  • In people with aspirin-induced asthma, an asthma attack occurs after ingesting aspirin. (acnearticle.info)
  • Between 2% and 25% of adults with asthma are sensitive to aspirin. (asthma.net)
  • Children with asthma may not be sensitive to aspirin at first. (foresthillspediatrics.com)
  • One study reported that a whopping one-quarter of people who needed to be put on a ventilator following a severe asthma attack were sensitive to aspirin. (acnearticle.info)
  • Thirty percent have moderate asthma that can be controlled with inhaled steroids, and the remaining 20% of patients have mild and intermittent asthma. (newswise.com)
  • Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma. (medscape.com)
  • Those who are affected after taking ibuprofen can have asthma symptoms that range from mild to severe. (medicalnewstoday.com)
  • Mild symptoms may only occur for short periods of time, while more severe asthma symptoms can last hours or days. (mountsinai.org)
  • ADAM33-V4*C was associated to asthma and mild asthma by the transmission disequilibrium test (TDT). (scielo.cl)
  • However, the numbers of cells and their state of activation, seem to show little difference between patients with severe asthma compared to patients with the mild-to-moderate form of the disease 3 - 5 . (ersjournals.com)
  • Although women with mild asthma are unlikely to have problems, patients with severe asthma are at greater risk of deterioration. (medscape.com)
  • Beasley R, Roche WR, Roberts JA, Holgate ST (1989) Cellular events in the bronchi in mild asthma and after bronchoprovocation. (springer.com)
  • Symptoms of asthma can be mild or severe. (northshore.org)
  • The symptoms of asthma, which can range from mild to life threatening, can usually be controlled with a combination of drugs and environmental changes. (bionity.com)
  • Symptoms may be managed by various asthma medications such as bronchodilators, antiinflammatories and asthma inhalers. (rightdiagnosis.com)
  • What medications trigger aspirin-induced asthma? (asthma.net)
  • Although it is called "aspirin-induced asthma," medications related to aspirin can also cause an attack. (asthma.net)
  • Asthma medications should be added or deleted as the frequency and severity of the patient's symptoms change. (medscape.com)
  • You probably already know that allergens like pet dander and dust mites can trigger your asthma symptoms, but, surprisingly, some medications can do the same thing. (acnearticle.info)
  • Some medications that contain aspirin may list the words acetylsalicylate , salicylic, or acetylsalicylic acid instead. (acnearticle.info)
  • Avoid adverse effect from asthma medications. (rxmed.com)
  • About 5% of asthmatic patients are sensitive to certain food preservatives and antioxidants, some of which are present even in medications used to manage asthma. (pharmacology2000.com)
  • After 12 months of avoiding benzoates in foods, drinks and medications, she remained asthma-free. (fedup.com.au)
  • The use of bronchodilators started in 1901, but it was not until the 1960s that the inflammatory component of asthma was recognized, and anti-inflammatory medications were added to the regimens. (bionity.com)
  • People with moderate-to-severe asthma should use conventional medications to help control symptoms. (stlukes-stl.com)
  • I have Samter's Triad syndrome, also known as Aspirin Induced Asthma (AIA). (fedup.com.au)
  • Pulse oximetry measurement is desirable in all patients with acute asthma to exclude hypoxemia. (medscape.com)
  • Association between human rhinovirus C and severity of acute asthma in children. (medscape.com)
  • Do not use for an acute asthma attack. (cvs.com)
  • not effective for acute asthma attack. (studystack.com)
  • Acute asthma exacerbation in children. (epnet.com)
  • Also, interested in finding out more about the efficacy of aspirin desensitization for this condition. (wikipedia.org)
  • Some children may be treated with a kind of therapy called aspirin desensitization. (foresthillspediatrics.com)
  • The study involved ACS patients who underwent aspirin desensitization and were eventually able to take the drug along with a P2Y12 agent. (physiciansweekly.com)
  • Some of these aspirin-allergic patients remain only on the P2Y12 inhibitor while some have the option to undergo aspirin challenge or desensitization if offered by their medical institution," Nguyen said. (physiciansweekly.com)
  • Post aspirin desensitization, aspirin allergic patients with ACS can then be started on dual antiplatelet therapy as per guidelines. (physiciansweekly.com)
  • All included patients also underwent successful inpatient aspirin challenge and desensitization and were started on aspirin along with P2Y12 inhibitor. (physiciansweekly.com)
  • All 12 STEMI patients underwent percutaneous coronary intervention, and 6 of these received stents before aspirin desensitization and 6 received stents after aspirin desensitization. (physiciansweekly.com)
  • Among 24 NSTEMI patients who received stents, 4 underwent aspirin desensitization before the stent procedure and 20 were desensitized after. (physiciansweekly.com)
  • Aspirin desensitization on challenge or desensitization typically occurred about two to three days after ACS presentation. (physiciansweekly.com)
  • Without the surgery, the aspirin desensitization would leave the previously established inflammatory disease untreated, and without the work of the allergist, the polyps would return, so the dual approach is critical," Bosso said. (medindia.net)
  • In this study, Bosso and his team evaluated 37 AERD patients who underwent both surgery and aspirin desensitization. (medindia.net)
  • It's important for patients to be aware of the possible benefits and drawbacks of undergoing aspirin desensitization and these findings may help inform patients' decisions," Bosso said. (medindia.net)
  • ADRB2-c.16*AG is a risk factor (3.5-fold), while genotype GSDML-236*TT was protective (4-fold) for moderate-severe asthma. (scielo.cl)
  • The findings prompt for longitudinal studies and interventions to define the mechanisms in severe asthma. (ersjournals.com)
  • Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: international study of asthma and allergies in childhood phase three. (medscape.com)
  • People who have allergies have a greater chance of getting asthma. (epnet.com)
  • Family history of asthma or allergies. (rxmed.com)
  • Asthma is much more common in people who have allergies, though not everyone with allergies gets asthma. (northshore.org)
  • And not everyone with asthma has allergies. (northshore.org)
  • METHODS: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. (koreamed.org)
  • About half of all cases develop before the age of 10, and many children with asthma also have allergies. (stlukes-stl.com)
  • In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (bioportfolio.com)
  • Aspirin better than clopidogrel on major adverse cardiovascular events reduction after ischemic stroke: A retrospective nationwide cohort study. (bioportfolio.com)
  • Among patients with acute coronary syndrome (ACS) who could not initially take dual antiplatelet therapy (DAPT) due to aspirin allergy, P2Y12 monotherapy did not appear to be associated with short-term adverse cardiovascular outcomes in a newly reported study. (physiciansweekly.com)
  • Researcher Amie Nguyen, MD, of Kaiser Permanente Los Angeles Medical Center, presented the findings by video during a session on adverse drug reactions at the virtual meeting of the American College of Allergy, Asthma, & Immunology - ACAAI 2020 - held Nov. 13-15. (physiciansweekly.com)
  • The lack of short-term adverse cardiac outcomes suggests that the anti-platelet effect of P2Y12 inhibitors might suffice in situations in which immediate aspirin administration is prohibited, Nguyen said. (physiciansweekly.com)
  • Histamine in wine has been associated with triggering a wide spectrum of adverse symptoms, including sneezing, rhinitis, itching, flushing, headache and asthma. (wines.com)
  • Dipeptidyl Peptidase-4 Inhibitor Induced Angioedema - An Overlooked Adverse Drug Reaction? (eurekaselect.com)
  • 40 adverse events occurred among 29 participants in the aspirin group and 37 adverse events among 27 participants in the placebo group (incidence rate ratio 1.1, 95% confidence interval 0.7 to 1.7, P=0.71). (bmj.com)
  • Exposure before age 1 to pet dander, cockroach, mice allergens, and certain types of household bacteria may actually help protect against the development of wheezing and asthma. (stlukes-stl.com)
  • asthma reactions induced by exercise, cold air, allergens and aspirin. (studystack.com)
  • Among those who are susceptible, being exposed to environmental factors, such as allergens, substances that cause an allergic reaction, or infections, may increase the chance of developing asthma. (stlukes-stl.com)
  • These patients suffer from nasal polyps, severe sinusitis, and asthma. (medindia.net)
  • That is when they figured out I was sensitive to salicylates in foods and yellow #5 dye and was diagnosed with what they called Triad Asthma back then. (fedup.com.au)
  • It also has small amounts of salicylates, which are similar to aspirin. (webmd.com)
  • The purpose of this study is to compare aspirin/acetylsalicylic acid+ clopidogrel with aspirin/acetylsalicylic acid alone as antithrombotic treatment following TAVI for the prevention of m. (bioportfolio.com)
  • 4 Aspirin-induced asthma is more common in adults than children. (asthma.net)
  • An in-depth report on how asthma is diagnosed, treated, and managed in adults. (limamemorial.org)
  • This phenomenon is known as aspirin-induced asthma, and it affects about 10% of adults with asthma. (acnearticle.info)
  • Previous studies have suggested less cardioprotective benefit of aspirin in adults with diabetes, raising concerns about "aspirin resistance" and potentially reduced effectiveness for prevention of ca. (bioportfolio.com)
  • Around 20 percent of adults with asthma will have aspirin-induced asthma. (medicalnewstoday.com)
  • Asthma exacerbation in adults and adolescents. (epnet.com)
  • While most people develop asthma as children, adults can also develop asthma. (mountsinai.org)
  • exposure to certain elements in the workplace, as well as industrial or wood dusts, chemical fumes and vapors, and molds, can cause the development of asthma even in adults with no history of it. (mountainside-medical.com)
  • Asthma surveillance data in recent decades have revealed that a disparate burden of asthma exists in certain demographic subgroups: in children compared with adults, in women compared with men, in blacks compared with whites, and among Hispanics of Puerto Rican heritage compared with those of Mexican descent. (clevelandclinicmeded.com)
  • This topic provides information about asthma in teens and adults. (northshore.org)
  • Which healthy adults should take aspirin? (semanticscholar.org)
  • Participants 251 adults with venous leg ulcers who could safely be treated with aspirin or placebo: 125 were randomised to aspirin and 126 to placebo. (bmj.com)
  • I had what they called mini-anaphylactic reactions nearly every day and was put on prednisone, asthma medication and an antihistamine on a daily schedule to control reactions. (fedup.com.au)
  • All patients were successfully treated through these reactions and were able to tolerate 81 mg of aspirin. (physiciansweekly.com)
  • are major cyclooxygenase metabolites of arachidonic acid produced during allergic reactions including asthma. (nii.ac.jp)
  • EP pathway in allergic reactions, we subject mice deficient in DP, EP1, EP2, EP3 and EP4 receptor individually to ovalbumin-induced allergic asthma as a model of type I allergy. (nii.ac.jp)
  • To better understand short-term cardiac outcomes among aspirin sensitive patients who initially receive P2Y12 monotherapy in place of aspirin, Nguyen and colleagues performed a retrospective chart review involving all in-patient consultations to the Kaiser Permanente Los Angles Medical Center allergy center for self-reported allergy to aspirin between 2008 through 2018. (physiciansweekly.com)
  • McFadden ER Jr. Exercise-induced airway obstruction. (medscape.com)
  • Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. (medscape.com)
  • We also discuss the involvement of these mechanisms in the currently recognized phenotypes of adult-onset asthma. (hindawi.com)
  • We start by combining the information on cluster analyses identifying adult-onset asthma phenotypes, to enable association of the pathogenetic mechanisms with phenotypes, if possible. (hindawi.com)
  • By combining information from cluster analyses concentrating on patients with adult-onset asthma [ 3 ] and of those including also patients with childhood-onset asthma [ 14 - 19 ], at least five different subtypes of late- or adult-onset asthma could be extracted (Figure 1 and Table 1 ). (hindawi.com)
  • In adult onset asthma, females are more often affected than males. (rxmed.com)
  • A Dutch woman who developed adult onset asthma within three months of starting a weight loss program had been snacking on dried fruit and nut trail mix. (fedup.com.au)
  • G) in the tissue factor gene promoter is associated with adult-onset asthma. (nii.ac.jp)
  • Aspirin resistance is poorly studied in these patients, and to our knowledge no study has been made to assess the prognosis value of aspirin resistance on cardiovascular outcomes in critical limb ischaemia patients. (bioportfolio.com)
  • However, outcomes of aspirin monotherapy of renal cell carcinoma (RCC) are inconsistent across studies. (bioportfolio.com)
  • Evidence-based practice guidelines have been disseminated with a goal of encouraging more frequent use of anti-inflammatory therapy to improve asthma outcomes. (clevelandclinicmeded.com)
  • 2500 g) with childhood asthma outcomes. (uni-wuerzburg.de)
  • The criteria required subjects to have undergone at least one asthma exacerbation in the past year requiring oral steroid treatment. (ersjournals.com)
  • For instance, although between just 21 and 63 Geisinger asthma patients live in Bradford County - which has the second-most shale wells as any county in the state - data comparing Bradford County asthma exacerbation rates with counties with no shale development might have given a better picture of whether there was an association. (energyindepth.org)
  • An acute exacerbation of asthma is referred to as an asthma attack . (bionity.com)
  • Essentially, asthma is an inflammatory lung condition that makes it difficult to breathe properly. (limamemorial.org)
  • Aspirin is a common anti-inflammatory drug, and it can trigger asthma symptoms. (acnearticle.info)
  • Inactivate NF-kB, the transcription factor that induces the production of TNF-alpha, among other inflammatory agents. (studystack.com)
  • It may be due to aspirin's ability to regulate the brain chemical serotonin or to the anti-inflammatory properties of aspirin,' says Dr. Hreib. (everydayhealth.com)
  • By becoming desensitized to aspirin and then taking it for long-term therapy, there is a significant reduction in the regrowth of any new inflammatory polyp disease. (medindia.net)
  • The knowledge that asthma is an inflammatory disorder has become fundamental to our definition of asthma. (clevelandclinicmeded.com)
  • The aim of the present study was to examine the effects of leukotriene (LT) receptor antagonist on aspirin challenge on eosinophil activity and chemical mediators released into the airway of asthmatic patients. (unboundmedicine.com)
  • METHODS: In study 1, 24 asthmatic patients with a strong history of wine induced asthma were screened. (wines.com)
  • Aspirin has been advocated as an adjuvant treatment for venous leg ulcers, 7 based on suggestive evidence from two trials using 300 mg doses, 8 9 although a Cochrane review concluded the evidence was insufficient to be definitive. (bmj.com)
  • 10 The use of aspirin for treating venous leg ulcers has biological plausibility. (bmj.com)
  • A drug combination of aspirin and dipyridamole that functions as a PLATELET AGGREGATION INHIBITOR, used to prevent THROMBOSIS and STROKE in TRANSIENT ISCHEMIC ATTACK patients. (bioportfolio.com)
  • Aspirin could interrupt platelet aggregation and activation through inhibition of platelet cyclooxygenase or vessel wall cyclooxygenase. (bmj.com)
  • A significant number of patients with aspirin-induced asthma also have steroid-dependant asthma where they require regular steroidal asthma medication to maintain normal lung functioning. (rightdiagnosis.com)
  • Even the well-knowns conditions such as asthma or lung cancer often fail to be. (rightdiagnosis.com)
  • Additional information available from the Asthma and Allergy Foundation of America, 1717 Massachusetts Ave., Suite 305, Washington, DC 20036, Or The Canadian Lung Association www.lung.ca. (rxmed.com)
  • Occupational asthma which affects about 5% to 10% of the world population is probably the most common occupational lung disease. (pharmacology2000.com)
  • Meadowsweet can cause lung spasms, so there is a concern that it might make asthma worse. (webmd.com)
  • They may be able to diagnose your condition based on your history of ingesting aspirin and then suffering an asthma attack, but since other factors can also trigger asthma, they may want to perform an oral aspirin challenge. (acnearticle.info)
  • During an oral aspirin challenge , your allergist will have you ingest aspirin under their supervision. (acnearticle.info)
  • Interventions 150 mg oral aspirin daily or matching placebo for up to 24 weeks treatment, with compression therapy as standard background treatment. (bmj.com)