Asthenia: Clinical sign or symptom manifested as debility, or lack or loss of strength and energy.Neurocirculatory Asthenia: A clinical syndrome characterized by palpitation, SHORTNESS OF BREATH, labored breathing, subjective complaints of effort and discomfort, all following slight PHYSICAL EXERTION. Other symptoms may be DIZZINESS, tremulousness, SWEATING, and INSOMNIA. Neurocirculatory asthenia is most typically seen as a form of anxiety disorder.EponymsDrug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Taxoids: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.DeoxycytidineMaximum Tolerated Dose: The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Camptothecin: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.ThiophenesAntineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.Organoplatinum Compounds: Organic compounds which contain platinum as an integral part of the molecule.Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Lung Neoplasms: Tumors or cancer of the LUNG.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Pyrroles: Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.QuinazolinesCarcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Leucovorin: The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.Indoles: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.Breast Neoplasms: Tumors or cancer of the human BREAST.Materia Medica: Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.Homeopathy: A system of therapeutics founded by Samuel Hahnemann (1755-1843), based on the Law of Similars where "like cures like". Diseases are treated by highly diluted substances that cause, in healthy persons, symptoms like those of the disease to be treated.Arnica: A plant genus of the family ASTERACEAE. The dried flower heads of Arnica montana are used externally as a counterirritant and tincture for sprains and bruises, either as crude extract or in homeopathic dilution (HOMEOPATHY). Arnica contains volatile oils (OILS, VOLATILE), arnicin, arnisterol, FLAVONOIDS; TANNINS; and resin. The common name of Wolf's Bane is similar to the common name for ACONITUM.Strychnos nux-vomica: A plant genus of the genus STRYCHNOS, family LOGANIACEAE that is the source of STRYCHNINE.Medicine, Chinese Traditional: A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.Comfrey: Perennial herb Symphytum officinale, in the family Boraginaceae, used topically for wound healing. It contains ALLANTOIN, carotene, essential oils (OILS, VOLATILE); GLYCOSIDES; mucilage, resin, SAPONINS; TANNINS; triterpenoids, VITAMIN B12, and ZINC. Comfrey also contains PYRROLIZIDINE ALKALOIDS and is hepatotoxic if ingested.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Syndrome: A characteristic symptom complex.Sympathetic Nervous System: The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.ReadingMilitary Personnel: Persons including soldiers involved with the armed forces.

Concurrent conventionally factionated radiotherapy and weekly docetaxel in the treatment of stage IIIb non-small-cell lung carcinoma. (1/55)

Docetaxel has shown remarkable radiosensitizing in vitro properties. In a previous phase I/II dose escalation study in non-small-cell lung cancer (NSCLC) we observed a high response rate after concomitant boost radiotherapy and weekly docetaxel. The maximum tolerated dose was 30 mg m(-2) week(-1). In the present phase II study we evaluated whether weekly docetaxel and conventionally fractionated radiotherapy could be better tolerated and equally effective in the treatment of locally advanced NSCLC. Thirty-five patients with T3, T4/N2, T3/M0-staged disease were recruited. Docetaxel (30 mg m(-2)) was given as a 30 min infusion once a week. Asthenia and radiation-induced oesophagitis were the main side-effects of the regimen enforcing 2-week treatment delay in 6/35 (17%) patients and minor delay (3-7 days) in another 11/35 (31%) patients. Neutrophil, platelet and haemoglobin toxicity was minimal, but pronounced lymphocytopenia was observed. Complete response (CR) of the chest disease was observed in 12/35 (34%) patients and partial response in 16/35 (46%). Although not statistically significant (P=0.19), a higher CR rate (8/18; 44%) was observed in patients who accomplished their therapy within the scheduled treatment time (44-47 days) as compared to patients that interrupted their treatment for several days due to treatment-related toxicity (CR 4/17; 23%). The overall survival and the local progression-free survival at 1 year was 48% and 60% respectively. We conclude that docetaxel combination with radiotherapy is a promising approach for the management of locally advanced NSCLC that results in high CR rate. Further trials with docetaxel-based radiochemotherapy should integrate accelerated radiotherapy together with cytoprotection.  (+info)

Collagen dysplasia (cutaneous asthenia) in a cat. (2/55)

Hereditary collagen dysplasias comprise a complex group of connective-tissue disorders that result in the reduced tensile strength of affected tissues. These processes are called cutaneous asthenia in the skin of dogs and cats. We report here the case of a crossbred male cat, aged 6 months, that presented with two skin wounds in the region of the right thorax and right iliac tuberosity. The skin of these regions and of the animal's dorsum was hyperextensible, smooth to the touch, and easily torn with minor trauma. Microscopic examination of skin samples revealed reduced dermal connective tissue consisting of shortened and fragmented collagen fibers. Normal fibers were intermingled with altered fibers. Ultrastructural changes in collagen fibers included disorientation of fibrils within the same bundle, marked spacing differences, and variation in the diameter of transverse sections. The fibrils maintained the transverse striations characteristic of normal collagen.  (+info)

Sequelae of sarin toxicity at one and three years after exposure in Matsumoto, Japan. (3/55)

In order to clarify the later sequelae of sarin poisoning that occurred in Matsumoto City, Japan, on June 27, 1994, a cohort study was conducted on all persons (2052 Japanese people) inhabiting an area 1050 meters from north to south and 850 meters from east to west with the sarin release site in the center. Respondents numbered 1237 and 836 people when surveys were conducted at one and three years after the sarin incident, respectively. Numbers of persons with symptoms of sarin toxicity were compared between sarin victims and non-victims. Of the respondents, 58 and 46 people had symptoms associated with sarin such as fatigue, asthenia, shoulder stiffness, asthenopia and blurred vision at both points of the survey, respectively. The prevalences were low; some complained of insomnia, had bad dreams, difficulty in smoking, husky voice, slight fever and palpitation. The victims who had symptoms one year after the incident had a lower erythrocyte cholinesterase activity than did those who did not have symptoms at the early stage; such persons lived in an area with a 500 meter long axis north east from the sarin release site. The three-year cohort study clearly showed that the odds ratios of almost all of the symptoms were high in the sarin-exposed group, suggesting a positive relationship between symptoms and grades of exposure to sarin. These results suggest that symptoms reported by many victims of the sarin incident are thought to be sequelae related to sarin exposure.  (+info)

Interferon treatment of chronic hepatitis C in patients cured of pediatric malignancies. (4/55)

BACKGROUND AND OBJECTIVE: Chronic hepatitis C was a frequent complication in patients treated for malignancy until the introduction of anti-HCV screening tests for blood donors. The association between chronic hepatitis C and progression to cirrhosis and hepatocellular carcinoma has been reported in about 20% and 5% of patients, respectively, within 20-30 years of infection. In adult patients, interferon has proved to be effective in decreasing the abnormal values of transaminases and the level of HCV viremia. Our purpose was to assess efficacy of and tolerance to interferon in a group of young patients who had acquired HCV infection during a period of chemotherapy. DESIGN AND METHODS: Interferon-a (IFN) was administered to 26 adolescents and young adults (13 males, age range 17-36 years; median age 24) with chronic hepatitis C, including 4 with hepatitis B virus co-infection, who had been treated for leukemia or solid tumor 5 to 19 years before joining this trial. Patients were treated with natural IFN alpha at a dose of 4 MU/m(2) thrice weekly for 12 months and followed up for another 6 months thereafter. RESULTS: Nine patients stopped treatment during the first 6 months because of side effects (2 cases) or lack of response. At the end of the trial, 8 (31%) cases had responded, with alanine amino-transferase normalization and clearance of hepatitis C virus (HCV) RNA. A sustained response was only documented in 15% of cases, however, irrespective of any hepatitis B virus co-infection. The 2 patients with HCV genotype 2 were both responders, whereas only 8% of those with genotype 1 responded. INTERPRETATION AND CONCLUSIONS: These data show that the efficacy of IFN in this series of young patients is similar to that reported for otherwise healthy adults with hepatitis C. Patients with genotype 2 are strong candidates for IFN treatment while other therapeutic strategies should be designed for patients with HCV genotype 1.  (+info)

Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: a University of Chicago Phase II Consortium study. (5/55)

PURPOSE: Flavopiridol is the first cyclin-dependent kinase (cdk) inhibitor to enter clinical trials. Serum levels of flavopiridol obtained during phase I studies were sufficient to inhibit in vitro cancer cell growth. Because responses were observed in kidney cancer patients in the phase I trials, we performed a phase II trial of flavopiridol in this patient population. PATIENTS AND METHODS: Thirty-five minimally pretreated patients were accrued using a standard two-step mechanism. Flavopiridol (50 mg/m(2)/d) was administered by continuous infusion for 72 hours every 2 weeks, and response was evaluated every 8 weeks. Peripheral blood mononuclear cells (PBMCs) were collected at baseline, at completion of drug infusion, and on day 7 of the first therapy cycle, and cell cycle parameters after phytohemagglutinin and interleukin-2 stimulation were assessed. RESULTS: There were two objective responses (response rate = 6%, 95% confidence interval, 1% to 20%). The most common toxicities were asthenia, occurring in 83% of patients (grade 3 or 4 in 9%), and diarrhea, occurring in 77% of patients (grade 3 or 4 in 20%). Also, nine patients (26%) experienced grade 3 or 4 vascular thrombotic events, including one myocardial infarction, two transient neurologic ischemic attacks, four deep venous thrombosis, and two pulmonary emboli. Cell cycle studies did not reveal any effect of flavopiridol on stimulated PBMCs. CONCLUSION: Flavopiridol, at the dose and schedule administered in this trial, is ineffective in metastatic renal cancer. In addition to the diarrhea observed in phase I studies, we also observed a higher incidence of asthenia and serious vascular thrombotic events than expected.  (+info)

Effects of sibutramine alone and with alcohol on cognitive function in healthy volunteers. (6/55)

AIMS: To investigate the effects of sibutramine in combination with alcohol in a double-blind, randomised, placebo-controlled, four-way crossover study in 20 healthy volunteers. METHODS: On each study day each volunteer received either: sibutramine 20 mg+0.5 g kg-1 alcohol; sibutramine 20 mg+placebo alcohol; placebo capsules+0.5 g kg-1 alcohol; or placebo capsules+placebo alcohol. Alcohol was administered 2 h following ingestion of the study capsules. During each study day, assessments of cognitive performance were made prior to dosing, and at 3, 4.5, 6 and 10 h post dosing. Blood alcohol concentration was estimated using a breath alcometer immediately prior to each cognitive performance test session. Each study day was followed by a minimum 7 day washout period. RESULTS: Alcohol was found to produce statistically significant impairments in tests of attention (maximum impairment to speed of digit vigilance=49 ms) and episodic memory (maximum impairment to speed of word recognition=74 ms). Alcohol also increased body sway (maximum increase 17.4 units) and lowered self rated alertness (maximum decrease 13.6 mm). These effects were produced by an inferred blood alcohol level of 53.2 mg dl-1. Sibutramine was not found to potentiate any of the effects of alcohol. There was a small, yet statistically significant, interaction effect observed on the sensitivity index of the picture recognition task. In this test, the combined effects of sibutramine and alcohol were smaller than the impairments produced by alcohol alone. Sibutramine, when dosed alone, was associated with improved performance on several tasks. Sibutramine improved attention (mean speed of digit vigilance improved by 21 ms), picture recognition speed (improvement at 3=81) and motor control (tracking error at 3 h reduced by 1.58 mm). Also sibutramine improved postural stability (reducing body sway at 3 h by 14.2 units). Adverse events reported were unremarkable and consistent with the known pharmacology of sibutramine and alcohol. CONCLUSIONS: There was little evidence of a clinically relevant interaction of sibutramine with the impairment of cognitive function produced by alcohol in healthy volunteers. The single statistically significant interaction indicated a reduction, rather than a worsening, of alcohol-induced impairment when sibutramine is taken concomitantly. Sibutramine when administered alone is associated with improved performance on several tasks.  (+info)

A phase I and pharmacokinetic study of the combination of capecitabine and docetaxel in patients with advanced solid tumours. (7/55)

Capecitabine and docetaxel are both active against a variety of solid tumours, while their toxicity profiles only partly overlap. This phase I study was performed to determine the maximum tolerated dose (MTD) and side-effects of the combination, and to establish whether there is any pharmacokinetic interaction between the two compounds. Thirty-three patients were treated with capecitabine administered orally twice daily on days 1-14, and docetaxel given as a 1 h intravenous infusion on day 1. Treatment was repeated every 3 weeks. The dose of capecitabine ranged from 825 to 1250 mg m(-2) twice a day and of docetaxel from 75 to 100 mg m(-2). The dose-limiting toxicity (DLT) was asthenia grade 2-3 at a dose of 1000 mg m(-2) bid of capecitabine combined with docetaxel 100 mg m(-2). Neutropenia grade 3-4 was common (68% of courses), but complicated by fever in only 2.4% of courses. Other non-haematological toxicities were mild to moderate. There was no pharmacokinetic interaction between the two drugs. Tumour responses included two complete responses and three partial responses. Capecitabine 825 mg m(-2) twice a day plus docetaxel 100 mg m(-2) was tolerable, as was capecitabine 1250 mg m(-2) twice a day plus docetaxel 75 mg m(-2).  (+info)

Efficacy and safety of haemodialysis treatment with the Hemocontrol biofeedback system: a prospective medium-term study. (8/55)

BACKGROUND: Hypovolaemia has been implicated as a major causal factor of morbidity during haemodialysis (HD). A model biofeedback control system for intra-HD blood volume (BV) changes modelling has been developed (Hemocontrol), Hospal Italy) to prevent destabilizing hypovolaemia. It is based on an adaptive controller incorporated in a HD machine (Integra), Hospal Italy). The Hemocontrol biofeedback system (HBS) monitors BV contraction during HD with an optical device. HBS modulates BV contraction rates by adjusting the ultrafiltration rate (UFR) and the refilling rate by adjusting dialysate conductivity (DC) in order to obtain the desired pre-determined BV trajectories. METHODS: Nineteen hypotension-prone uraemic patients (seven males, 12 females; mean age 64.5+/-3.0 SEM years; on maintenance HD for 80.5+/-13.2 months) volunteered for the present prospective study that compared the efficacy and safety of bicarbonate HD treatment equipped with HBS, as a whole, with the gold-standard bicarbonate treatment equipped with a constant UFR and DC (BD). The study included three phases: Medium-term studies started with one period of 6 months of BD and always had a follow-up period of HBS treatment ranging from 14 to 30 months (mean 24.0+/-1.6); short-term studies started in September 1999, when all patients went back to BD treatment for a wash-out period of 4 weeks and a short-term study period of a further 3 weeks (phase A). Afterwards, they once again started HBS treatment for a wash-out period of 4 weeks and a short-term study period of a further 3 weeks (phase B). Every patient underwent acute studies during a single HD run, once during phase A and once in phase B. Resistance (R) and reactance (Xc) measurements were obtained utilizing a single-frequency (50 kHz) tetrapolar bioimpedance analysis (BIA). Extracellular fluid volume (ECV) was calculated from R, Xc, and height and body weight measurements using the conventional BIA regression equations. RESULTS: The overall occurrence of symptomatic hypotension and muscle cramps was significantly less in HBS treatment in both medium- and short-term studies. Self-evaluation of intra- and inter-HD symptoms (worst score=0, best score=10) revealed a statistically significant difference, as far as post-HD asthenia was concerned (6.2+/-0.2 in HBS treatment vs 4.3+/-0.1 in BD treatment, P<0.0001). No difference was observed between the two treatments when comparing pre- and post-HD lying blood pressure, heart rate, body weights and body weight changes in medium- and short-term studies. The residual BV%/ Delta ECV% ratio, expression of the vascular refilling, was significantly higher during HBS treatment in acute studies. CONCLUSIONS: HBS treatment is effective in lowering hypovolaemia-associated morbidity compared with BD treatment; this could be related to a greater ECV stability. Furthermore, HBS is a safe treatment in the medium-term because these results are not achieved through potentially harmful changes in blood pressure, body weight, and serum sodium concentration.  (+info)

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Book the Comfort Inn & Suites - Located in the heart of Amarillo, this hotel is within 1 mi (2 km) of American Quarter Horse Association and American Quarter Horse Hall of Fame. Amarillo Museum of Art and Splash Amarillo are also within 3 mi (5 km).
Is Asthenia a common side effect of Zocor? View Asthenia Zocor side effect risks. Female, 93 years of age, was diagnosed with blood cholesterol increased and took Zocor 40 Mg, Once In The Evening.
Feeling ASTHENIA while using Plavix? ASTHENIA Causes, Patient Concerns and Latest Treatments and Plavix Reports and Side Effects.
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With Royal Blue Boon Too, ViaGen and Encore Genetics, have partnered to preserve some of the greatest genetics in cutting horse history. Royal Blue Boon, the donor mare, is the all-time leading producer of cutting horses in the world with personal lifetime earnings of $381,764 and produce earnings of well over $2.5 million dollars. It is this unique value of the mare that identified this registered American Quarter Horse as a specimen worthy of preservation. At 26, the old mare is seeing the end of her long and prosperous career and her reproductive days are well behind her. With that fact in mind, the owner of Royal Blue Boon made the decision to clone her cutting horse champion ...
The American Quarter Horse Journal, the horse-industrys complete source for the latest news and information, plus a schedule of horse shows and other horse events.
Cutaneous asthenia (literally, weak skin) is part of a group of hereditary disorders characterized by skin that is unusually stretchy and droopy. It is caused by a genetic mutation that is passed from parent to offspring.
Examining muscle biopsies, the research team found that the number of mitochondria were decreased in the triceps, but not gluteal muscles with aging. They also found changes in the muscle fiber type with aging. A high proportion of type II fibers (like in gluteus muscle) gives horses their speed whereas more type I fibers play a role in maintaining posture (like in triceps). With aging, the gluteus muscle develops more type I fibers and the triceps muscle develops more type IIA fibers with less IIX fiber types in both muscles. Although the activities of some mitochondrial enzymes also declined with aging, it was not associated with a decline in mitochondrial function. The authors attributed this lack of measurable mitochondrial dysfunction to either the horses not being old enough for dysfunction to exist yet (20 years horse = about 65 years human) or perhaps that aging in horse skeletal muscle is different from that of rodents and humans. Either way, understanding how our equine friends age is ...
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Hereditäre equine dermale Asthenie (HERDA) ist eine autosomal rezessive Hautkrankheit, die vor allem junge Quarter Horses und verwandte Rassen betrifft. Die Symptome sind charakterisiert durch leichte Verletzbarkeit und erhöhte Dehnbarkeit der Haut, meist in der Satelllage. Die Prognose ist vorsichtig zu stellen, denn die Pferde können nicht normal zum Reiten eingesetzt werden und müssen oft euthanasiert werden. Beim Quarter Horse ist HERDA mit einer Mutation im Cyclophilin B Gen (PPIB) assoziiert. Cyclophilin B ist ein Enzym, welches für die Tripelhelixbildung von Kollagen wichtig ist. Wir beschreiben hier eine Schweizer Jährlings-Stute mit Symptomen von HERDA, aber ohne Mutation im PPIB Gen und bei der auch Ehlers-Danlos Typ IV, Typ VI, Typ VIIA, Typ VIIB und Typ VIIC (Dermatosparaxis) als ätiologische Ursache ausgeschlossen werden konnten.. Schlüsselwörter: Hereditäre equine regionale dermale Asthenie,Warmblutfohlen,rezessive Hautkrankheit,Kollagen. ...
Asthenia is the medical term for the condition known as weakness. It is defined as a psychopathological condition marked by extreme temporary loss or chronic loss of strength and is also marked by sleep disturbance, fatigue and hyperesthesia. The physical weakness may affect the body as a whole or may affect only a part of the body. Asthenia leads to the inability to perform or finish a task although a certain task can be initiated except that there is difficulty due to a reduction or loss in the overall strength. The reduction in muscle strength is often associated with the underlying disease and other medical condition such as muscular dystrophy ...
Claire Gill is a transfer student from Coastal Carolina Community College in Jacksonville, NC. She has been riding for 13 years, competing in hunters, jumpers, and some eventing. Her first horse was an American Quarter Horse named Inspector Clueso. He taught her how to ride as an eight year old Cloverbud in 4H. Clue is now 25, retired and still living at her home in North Carolina. It wasnt until the age of 12 that Claire fell in love with jumping while she was leasing a very talented 15 year old pony. However, stadium jumping is just one of Claires passions. She also loves to play the piano and is sharpening her skills as she studies at Libertys School of Music. ...
Asthenia, Bicarbonate Decreased, Cognitive Defect Symptom Checker: Possible causes include Hyponatremia, Chronic Kidney Insufficiency, Diabetic Ketotic Coma. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
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CONCLUSION: The molecular functions of candidate proteins suggest that SAPDS of NSCLC is involved in the activity of complement, protease inhibitor, transcription factor and structural constituent of ribosome. Biological process analysis shows the different between different syndromes of NSCLC in regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism, protein metabolism and immune response. The SAPDS of NSCLC also plays an important role in the biological pathway of the complement cascade; terminal pathway of complement; innate immune system; initial triggering of complement; FOXA1 transcription factor network and immune system.. ...
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Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. Some corticosteroids have been shown to be teratogenic after dermal application in laboratory animals.. When administered to pregnant rats, rabbits, and mice, mometasone furoate increased fetal malformations. The doses that produced malformations also decreased fetal growth, as measured by lower fetal weights and/or delayed ossification. Mometasone furoate also caused dystocia and related complications when administered to rats during the end of pregnancy.. In mice, mometasone furoate caused cleft palate at subcutaneous doses of 60 mcg/kg and above. Fetal survival was reduced at 180 mcg/kg. No toxicity was observed at 20 mcg/kg. (Doses of 20, 60, and 180 mcg/kg in the mouse are approximately 0.01, 0.02, and 0.05 times the estimated maximum clinical topical dose from ELOCON Cream 0.1% on a mcg/m2 basis.). In rats, mometasone furoate produced umbilical hernias at ...
While the American Quarter Horse Association (AQHA) recognizes the therapeutic benefits of the drug furosemide, commonly known as Lasix, to help mitigate the occurrence of exercise-induced pulmonary hemorrhage (EIPH) in racehorses, the AQHA executive committee recently asked the AQHA Animal Welfare Commission to review the proposed prohibition of Lasix for show horses, set to be effective as of Jan. 1, 2018.. Balancing the use of therapeutic medication for the welfare of the horse in different types of competition, such as racing and showing, while minimizing or eliminating performance-enhancing properties of medication compounds has been a challenge in the equine industry. Lasix has been endorsed by several equine groups and the American Association of Equine Practitioners to lessen the occurrence of EIPH in racehorses. Consistent with such groups, the AQHA opposed the latest version of the newly introduced Horseracing Integrity Act of 2017, which would eliminate all race-day medications, ...
By Ty Wyant AQHA RACING-FEBRUARY 9, 2018--If you have ever watched "The Quarters" on TVG, Les Onaka has helped you. His insights surpass respected because of his commitment to extensive research and Quarter Horse racing. These extraordinary virtues have also attracted fans to Quarter Horse racing and more Thoroughbred players now understand how to handicap Quarter Horses. Onaka needs our help. Right now.. Due to diabetes, asthma and complications, Onaka is not able to work. Hes home now, but could return to the hospital at any moment. He takes up to 14 medications every day and has extreme issues covering expenses. Some days, he has passed on taking some of his medications to save money.. Dave Weaver, a TVG host, has worked with Onaka for 18 years on air. Their friendship goes back even further, as they sold tip sheets in front of Los Alamitos as teenagers.. "Les and I have called Los Al home," said Weaver. "Its great that weve gotten to work together.". Les has serious needs. He has an ...
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iAssessed by blinded independent central review.. iiAnalysis was done at 59.8% maturity.. The safety and tolerability profile of Lynparza in the SOLO3 trial was consistent with previous trials. The most common adverse events (AEs) ≥ 20% were nausea (65%), fatigue/asthenia (52%), anaemia (51%), vomiting (38%), diarrhoea (28%), neutropenia (23%) and abdominal pain (21%). The most common ≥ Grade 3 AEs were anaemia (21%), neutropenia (10%), fatigue/asthenia (5%) and thrombocytopenia (4%). AEs led to dose interruption in 48% of patients on Lynparza while 7% of patients discontinued treatment.. Lynparza, which is being jointly developed and commercialised by AstraZeneca and MSD, is approved for multiple indications in advanced ovarian cancer and metastatic breast cancer and has been used in over 20,000 patients worldwide.. About SOLO3. SOLO3 was a Phase III randomised, open-label, controlled, multicentre trial to evaluate the efficacy and safety of Lynparza tablets following two or more prior ...
Ruidoso Downs is under new ownership and management resulting from a recently completed acquisition. The new owners of Ruidoso Downs and the Ruidoso Horse Sale company have invested in this iconic track specifically to create a racing and sales environment that will provide fairness, stability, and integrity for all who race, buy and sell here. Simply stated, the opportunity to race at Ruidoso Downs is a privilege granted by its owners and not a right. ...
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TY - JOUR. T1 - Synergistic antiviral action of ribonucleotide reductase inhibitors and 3′-azido-3′-deoxythymidine on HIV type 1 infection in vitro. AU - Giacca, Mauro. AU - Borella, Stefania. AU - Calderazzo, Francesca. AU - Bianchi, Luigi Chieco. AU - DAgaro, Pierlanfranco. AU - Rampazzo, Chiara. AU - Bianchi, Vera. AU - Reichard, Peter. PY - 1996/5/20. Y1 - 1996/5/20. N2 - Ribonucleotide reductase inhibitors reduce the cellular supply of DNA precursors (dNTP) by interfering with their de novo synthesis. A secondary effect is the stimulation of the uptake and phosphorylation of extracellular deoxynucleosides, including their analogs, e.g., 3′-azidothymidine (AZT). Both effects are relevant to HIV replication, which requires dNTP and is impaired by the triphosphate of AZT. Earlier we demonstrated that ribonucleotide reductase inhibitors - hydroxyurea, and two deoxycytidine analogs specifically active in lymphoid cells - increased the phosphorylation of AZT in CEM cells by prolonging the ...
RATIONALE: Steroid therapy, such as mometasone furoate, may prevent radiation dermatitis caused by radiation therapy. It is not yet known whether mometasone furoate is more effective than a placebo in preventing radiation dermatitis.. PURPOSE: This randomized phase III trial is studying mometasone furoate to see how well it works compared to a placebo in preventing radiation dermatitis in patients undergoing radiation therapy to the breast or chest wall for invasive breast cancer or ductal carcinoma in situ. ...
John W. Hyde has been working in the entertainment industry for over 40 years. Born March 29, 1941 in Jackson, Michigan he is married to Kate Morris Hyde and lives in both Los Angeles County and Badger, California. Hyde is a member of both the Academy of Motion Picture Arts and Sciences and the Academy of Television Arts and Sciences where he has been nominated for five Emmy Awards, winning one. He is a former officer and director of The Cousteau Society. He was also a founding member, as well as Vice Chairman and Board member, of the American Film Market. Hyde and his wife own Fairlea Ranch and raise World Champion American Quarter Horses. Hyde graduated from New York University with additional international economic studies at Leiden University in the Netherlands. Prior to 1990 Hyde was involved in production, distribution and as a management consultant overseeing the domestic and foreign distribution of nearly 125 motion pictures and television shows. His production credits include Short ...
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Frost is a 26-year-old Appendix Quarter Horse from Enumclaw, WA. She has had her very own web page on Club Horse for 9 years, 10 months and 21 days.
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The subject is a timely one when the nervous systems of many executives and business men are cracking under the long continuing and constant stress of our times. Eventually this persistent load of tension would surely lead to absolute breakdown in the nervous, cardiac and renal spheres especially, unless some therapeutic agent could be applied that would stimulate the various tissues of our complex human mechanism so that they became able to withstand the constant shock of these cataclysmal forces.. Such agents are to be found among the various invaluable remedies in the homoeopathic materia medica. Naturally any sane medical or lay observer says, "But first remove the cause." Very wise and very true we grant, but we claim that, failing to be able to do the latter because of our impotence to control the vast economic factors at work, recourse to the former method is logical, sound and beneficial. This to my mind conforms to the best noblest in homoeopathic philosophy. Chininum arsenicosum. ...
Email. The lives and racing careers of Headturner and Jumpn Beduino will forever be linked. First, the 3-year-old Quarter Horse half-siblings are out of the same dam, Imjumpn. Furthermore, they seem to peak on the racetrack at the same time. Jumpn Beduino and Headturner were first and second in the Pacific Coast Quarter Horse Racing Association Futurity at Los Alamitos last October. Last weekend, they both won major derbies. Headturner, a gelding by Check Him Out, won Friday s $214,400 El Primero Del Ano Derby. The following night, Jumpn Beduino, a filly by Chicks Beduino, won the $175,500 La Primera Del Ano Derby for fillies. Both started from post 9. What are the chances of that happening, said Theresa DeNike, who co-owns Jumpn Beduino with her husband, Ed. A brother and sister winning derbies on back-to-back nights and from the same post position. While it may seem illogical for half-siblings to be the same age, Quarter Horse breeders are allowed to register more than one foal from a mare ...
BILD 1633 SE is a potent ribonucleotide reductase inhibitor that was under preclinical investigation with Bio-Méga (Boehringer Ingelheim) in Canada for the
Breeders cant entirely ensure the health of their foals, but smart planning and preparation can go a long way in preventing some of the most common injuries and problems young horses face.
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Founded in 1999, DVAuction is the oldest and most respected livestock internet marketing service. Specializing in the real-time internet broadcasting of sales and special events, DVAuction provides a unique online viewing experience that is free to the public. ...
Founded in 1999, DVAuction is the oldest and most respected livestock internet marketing service. Specializing in the real-time internet broadcasting of sales and special events, DVAuction provides a unique online viewing experience that is free to the public. ...
A man in his early 30s reported in January 2016 a history of fever, asthenia and erythematous rash during a stay in Haiti. On his return to Italy, ZIKV RNA was detected in his urine and saliva 91 days after symptom onset, and in his semen on day 188, six months after symptom onset. Our findings support the possibility of sexual transmission of ZIKV and highlight the importance of continuing to investigate non-vector-borne ZIKV infection.
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Horses have only been around for about two hundred thousand years, we cant ride a Hyracotherium can we? The very first horse was the size of a large rat. Invalid Information, also it needs more of a variety, TBs (Thoroughbreds), and Quarter Horses are both the fastest horses in the world, but the Thoroughbred is a bit faster and goes about 36,39-40 MPH. ...
Breeze is a lovely bay Quarter Horse. She has not been evaluated yet for her skills, but her beautiful Bay coloring is sure to attract attention! Right now, she is rehabilitating at our ranches, once her skills and ground manners will be determined, we will list more information. Until then we will list her as "trainable". Give us a call to find out the newest information.. ...
Im on week three of my trial run with Oxy-Gen Xtreme GI Care, and I feel comfortable enough with the product to let you all know what I think of it so far. Some background: A little over a month ago, I bought a 12-year-old appendix-bred Quarter Horse mare from a great friend of mine.…
Clinical trial: Effects of Mometasone Furoate/Formoterol Combination Versus Mometasone Furoate Alone in Persistent Asthmatics (Study P04334AM1)(COMPLETED)
The Florida Cracker Horse is a breed of horse from Florida in the United States. It is genetically and physically similar to many other Spanish-style horses, especially those from the Spanish Colonial Horse group. The Florida Cracker is a gaited breed known for its agility and speed. The Spanish first brought horses to Florida with their expeditions in the early 16th century; as colonial settlement progressed, they used the horses for herding cattle. These horses developed into the Florida Cracker type seen today, and continued to be used by Florida cowboys (known as "crackers") until the 1930s. At this point they were superseded by American Quarter Horses needed to work larger cattle brought to Florida during the Dust Bowl, and population numbers declined precipitously. Through the efforts of several private families and the Florida government, the breed was saved from extinction, but there is still concern about its low numbers. Both The Livestock Conservancy and the Equus Survival Trust ...
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Ann Perry remembers hoping for "a few good years" with the aging stallion. Those "few good years" stretched to over a decade of successful breeding seasons with the top mares in the country lining up in the driveway.. According to my AQHA printout, Zippo Pine Bar has 1,636 registered foals. Half of those are performance horses with a point total that takes the lid off any record in the book. The sons and daughters of this fantastic stallion have 43,168.5 AQHA points! In addition, by my count, there are 14 World Champions and 29 Reserve World Champions. In the world of Western pleasure, big money purses are still relatively unheard of (for example, the 1997 high money earner in Open competition took home $33,464 for the year). Keep that in mind and then realize that Zippo Pine Bar could have earned over $1.5 million dollars in the pleasure futurity business! Some of the top cutting horse sires in the business brag about offspring earnings well below this figure, and an NCHA Futurity Champion ...
Objective: To determine the effect of age, sex and season on some selected hematological parameters of quarter horses (QH) from the North East of Mexico. Materials and Me..
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The AQHA UK insist that all registered quarter horse stallions used for breeding are Five Panel Tested. Although the US has brought in the mandatory testing of Stallions they have not, as yet, included the mares. However the UK Association strongly recommend that all breeding mares are tested before you begin your breeding programme. The extract below is from the US QH Journal and explains the diseases that are found within the quarter horse breed; at the end there is a link to purchase the genetic test. The lab that is used is in the US, no other testing laboratory can be used if you want to put the information on the your horses passport.. These diseases cause pain and discomfort to the horse, as well as great emotional upset to owners, and are unfortunately accompanied by very large veterinary bills. Please read the information and have your horse tested if you think that it may be used for breeding in the future so that all relevant information can be readily available to any prospective ...
Thirty-two percent (32%) of patients experienced treatment-related adverse events, most commonly asthenia/fatigue (6 patients; 9%), decreased appetite (4 patients; 6%), arthralgia (2 patients; 3%), back pain (2 patients; 3%), diarrhea (2 patients; 3%), headache (2 patients; 3%), hot flushes (2 patients; 3%), and myalgia (2 patients; 3%). Most adverse events were mild to moderate.. Among ARADES-enrolled patients, 69 had progressive mCRPC; 37 patients were chemotherapy-naïve; and 32 were pretreated with chemotherapy. The median age of enrolled patients was 69 years (53-83 years). A total of 59 (86%) of patients had bone metastases and 12 (17%) had visceral disease.. In recent published comments about new nonsteroidal anti-androgens, including ODM-201, with its promising emerging data, as well as enzalutamide and ARN-209, another novel anti-androgen under study, the question was raised about as-yet undetermined differences, in efficacy or safety.[2]. Specifically, whether there are differences in ...
Arcalion® is manufactured by Serdia Pharmaceuticals.. Vitamin B1 or Thiamine is known to improve cognitive abilities but is has a lower absorption rate and less of it actually gets to the brain.. Sulbutiamine is a synthetic derivative of Vitamin B1, which molecule solves the difficulty with absorption, making this essential nutrient water-soluble so that it absorbs into your bloodstream more easily. Sulbutiamine is also better and quicker travels across the blood-brain barrier where it interacts with your central nervous system.. How does Sulbutiamine work?. After oral ingestion, Sulbutiamine is absorbed from the intestines into the bloodstream and circulates to the brain tissue. After penetrating the blood-brain barrier, Sulbutiamine is broken down into Vitamin B1 and certain related esters.. Thus, Sulbutiamine alleviates the symptoms of asthenia like weakness and loss of strength while increasing focus, physical and mental strength, energy. It also helps men and women become more vivacious, ...
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A five-week-old American Quarter Horse colt was presented for evaluation of a left hindlimb deformity and lameness. Radiographs of the left hindlimb revealed a varus deformity with recurvatum originating in the mid-diaphysis of the third metatarsal bone. Surgical correction was undertaken by performing an osteotomy through the centre of rotation of angulation located within the mid-diaphysis of the third metatarsal bone, and a four-ring hinged circular external fixator construct was applied. Distraction of the osteotomy site was performed over an 11 day period. ...
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During the inhaled corticosteroid (ICS) Dose Reduction period (max. of 4 weeks; min. of 1 week) of sequential ICS Dose Reduction (approximately 50% reduction in daily dose or discontinue according treatment scheme), subjects must demonstrate a measurable loss of asthma control, with both A) Decreased Lung Function (from the Screening value in absolute FEV1 of ,= 10% or ,= 220ml OR a decrease in AM PEFR of 25% from the average value for the pre-ICS Dose Reduction period on at least 2 consecutive days out of the last 7 days) AND B) Increased Symptoms (Total AM and PM symptom score of ,= 10 out of 24 (using 0-3 scale for each of 4 individual symptoms) on at least 2 days out of the last 7 days OR Increased use of rescue medication from the average value for the pre-ICS Dose Reduction period (one week) of ,= 2 puffs on at least 2 days out of the last 7 days ...
The AQHA will require a five panel test for all breeding stallions for 2015. The panel includes testing for GBED (glycogen branching enzyme deficiency), HERDA (hereditary equine regional dermal
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Third Stage: Resetting Metabolism (4 Weeks). The Third Stage resets your setpoint and recalculates your program if there is a fixed set-point taking longer to resolve. A fixed set-point states there is a certain amount of calories you must consume every day. This calorie amount is usually below what is required to lose the weight you need to lose. A fixed set-point prevents you from ever reaching your ideal weight and must be treated with more advanced supplementation. We may also recommend a longer term program at this stage ...
Sporadic, non-clustered, hospital-associated listeriosis is a relatively rare, but life-threatening disease. We identified 12 cases in adults at a large medical center in southern Taiwan over a period of 21 years, or 0.34 cases per year. In a similar study conducted at a large tertiary care hospital in China, Yang et al. found nine non-clustered hospital-associated cases over a period of 12 years, or 0.75 cases per year [31]. We also identified 23 community-associated cases. In the present study, 32 of the 35 cases (91.4%) were immunocompromised. This is similar to previous reports [1, 28, 30, 33]. The listeriosis-related mortality rate of 34.3% observed in the current study is similar to other reports (24-52%) [2]. The 60-day mortality rate was significantly higher in patients with hospital-associated than community-associated listeriosis (66.7% vs. 17.4%, p = 0.007). Other reports showed a mortality rate of hospital-associated listeriosis of 27.2-53% [30, 31].. Although it may be argued that a ...
Mometasone is a steroid. It prevents the release of substances in the body that cause inflammation. Mometasone nasal (for use in the nose) is used to treat nasal symptoms of seasonal or year-round allergies, including congestion, sneezing, and runny nose. Mometasone nasal is approved for this use in adults and children...
In this lecture from the NSCAs 2014 National Conference, Trent Herda talks about using supplementation to build muscle mass. He discusses protein, the impact of resistance training, what data is currently available, and introduces some newer supplements.
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C1 and C2 are fully enrolled with 106 and 107 treated pts, respectively. At initial diagnosis, 32% (C1) and 25% (C2) of pts had MBC. In the neoadjuvant and adjuvant settings, 56% (C1) and 32% (C2) of pts had received chemotherapy, including a taxane (39% and 21%) or an anthracycline (39% and 26%); 41% and 18% had prior T exposure. At the data cut-off of 5 March 2014, the median number of cycles received in C1 was 15 for P + T and 9.5 for V, and in C2 was 10 for P + T and 9 for V. AEs were reported by 99% (C1) and 98% (C2) of pts. Grade ≥3 AEs were reported by 59% (C1) and 69% (C2) of pts. The grade ≥3 AEs in ≥5 pts in either cohort were neutropenia, leucopenia, diarrhoea, fatigue, febrile neutropenia, hypertension and asthenia. Serious AEs were reported by 29% (C1) and 33% (C2) of pts. Interim best overall response data from C1 will be presented. ...
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A Quarter Horse in Central Kentucky was euthanized after being struck by a car while standing in his stall, kypost.com reported. Driver Adam Smith went off the road while attempting to avoid another vehicle on a sharp curve, sending his car into the barn
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment ...
CASE DESCRIPTION: A 12-year-old 500-kg (1,100-lb) American Quarter Horse mare was evaluated because of chronic mucopurulent, bloody discharge from the left nostril, inspiratory dyspnea, and respiratory noise. CLINICAL FINDINGS: The horse had severe inspiratory dyspnea and stertorous respiration with no airflow from the left nostril. A temporary tracheostomy was performed. Endoscopy revealed a tan mass protruding from the left middle nasal meatus into the left common nasal meatus; it extended caudally into the nasopharynx and around the caudal edge of the nasal septum into the right nasal cavity. Radiographically, a soft tissue opacity was evident in most of the left nasal cavity and left paranasal sinuses. Cytologic examination of mass tissue revealed evidence of pyogranulomatous rhinitis; thickly encapsulated, budding yeast typical of Cryptococcus neoformans were detected. TREATMENT AND OUTCOME: While the horse was sedated and in a standing position, the fungal granuloma was removed from the paranasal
A 4-week-old American Quarter Horse colt presented with a recent history of diarrhea and decreased activity level. On initial physical examination, the animal was bright and alert and major findings were limited to a loud systolic heart murmur radiating widely over both sides of the thorax. While in the hospital, the clinical condition of the foal warranted further imaging to determine the cause and extent of cardiac disease. A variety of congenital cardiac malformations were identified during echocardiographic examination and autopsy, including a double outlet right ventricle and a subpulmonary interventricular septal defect (Taussig-Bing anomaly), ventricular inversion with atrioventricular discordance, tricuspid valve atresia, a septum primum interatrial septal defect, mitral valve dysplasia with a cleft in the septal mitral valve cusp, aortic, and subaortic stenosis, tubular hypoplasia of the ascending aorta and the aortic arch, a patent ductus arteriosus, an aberrant circumflex coronary ...
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Chance is a 7 year old Tobiano Paint Quarter Horse.. Chance has been a Part of the Scott MacMeeken family for approx. 4 years.. Chances BFF is Cinnamon a Palomino Quarter Horse.. ...
Pet podcast #39 features an interview with Dr. Lee a veterinarian in Mesa and Phoenix Arizona. In this interview we discuss diseases and health problems common to large dogs. Some of these problems include elbow and hip dysplasia as well …. ...
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Reduced libido is widely considered the most prominent symptomatic reflection of low testosterone (T) levels in men [1, 2] . Testosterone deficiency (TD) afflicts approximately 30% of men aged 40-79 years, with an increase in prevalence strongly associated with aging and common medical conditions including obesity, diabetes, and hypertension [3]. Although decreased libido is a concern often expressed by aging patients [4], it is difficult to measure comprehensively, being multifactorially determined and associated with both psychosocial and organic factors [5]. This phenomenon of hypogonadism due to aging has also been described as testosterone deficiency syndrome, late-onset hypogonadism, and andropause. Symptoms of this condition resemble those of normal aging and include changing body composition (osteopenia, increased adiposity, decreased muscle mass), decline in energy and stamina, decreased cognitive function, decreased libido, and erectile dysfunction [6], systolic hypertension, carotid ...
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... is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar.[5] It works by blocking the "reuptake" transporters for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin (5-hydroxytryptamine) and norepinephrine (noradrenaline). It is approximately 10 times more potent at inhibiting serotonin uptake than norepinephrine uptake.[6]. ...
Neurocirculatory asthenia. *(F45.4) Persistent somatoform pain disorder *Psychalgia. *(F45.8) Other somatoform disorders ...
At ASCO 2007, results from the SHARP trial[13] were presented, which showed efficacy of sorafenib in hepatocellular carcinoma. The primary endpoint was median overall survival, which showed a 44% improvement in patients who received sorafenib compared to placebo (hazard ratio 0.69; 95% CI, 0.55 to 0.87; p=0.0001). Both median survival and time to progression showed 3-month improvements; however, there was no significant difference in median time to symptomatic progression (p=0.77). There was no difference in quality of life measures, possibly attributable to toxicity of sorafenib or symptoms related to underlying progression of liver disease. Of note, this trial only included patients with Child-Pugh Class A (i.e. mildest) cirrhosis.[13] Because of this trial Sorafenib obtained FDA approval for the treatment of advanced hepatocellular carcinoma in November 2007.[4] In a randomized, double-blind, phase II trial combining sorafenib with doxorubicin, the median time to progression was not ...
... asthenia". Despite being omitted by the American Psychiatric Association's DSM in 1980, neurasthenia is listed in an appendix ...
... asthenia and true asthenia from myasthenia is often difficult, and in time apparent psychogenic asthenia accompanying many ... "Asthenia" redirects here. The tortrix moth genus is considered a junior synonym of Epinotia. Weakness or asthenia is a symptom ... Asthenia (Greek: ἀσθένεια, lit lack of strength but also disease) is a medical term referring to a condition in which the body ... Asthenia is also a side effect of some medications and treatments, such as Ritonavir (a protease inhibitor used in HIV ...
Asthenia Weight gain or loss. Usually gain, paroxetine tends to produce more weight gain than other SSRIs. Confusion Emotional ...
Asthenia - 4.19 * Always - 4.12 * Easy Target - 2.21 * All of This - 4.40 * Here's Your Letter - 2.54 ...
... neurocirculatory asthenia, primary neurasthenia, and subacute asthenia. Da Costa himself called it irritable heart and the term ... neurocirculatory asthenia, primary neurasthenia, subacute asthenia and irritable heart. The World Health Organization ... Neurocirculatory asthenia is most typically seen as a form of anxiety disorder. Engel CC (2004). "Post-war syndromes: ... For example, Oglesby Paul writes that "Not all patients with neurocirculatory asthenia have a cardiac neurosis, and not all ...
The condition's name derives from asthenia, which is a medical term denoting a feeling of weakness without actual loss of ... "Asthenia-Does It Exist in Space?". Psychosomatic Medicine. 63 (6): 874-80. doi:10.1097/00006842-200111000-00004. PMID 11719624 ...
"Asthenia - Does It Exist in Space?". Psychosomatic Medicine. 63 (6): 874-80. doi:10.1097/00006842-200111000-00004. PMID ...
Asthenia - Does it exist in space? Psychosom. Med., 63, 874-880. Palinkas, L.A. (1991). Group adaptation and individual ...
Fatigue (9.2%), weight gain (5.0%), asthenia (1.1%). A teratology study conducted in rabbits found that a dose of 150 mg/kg/day ...
Drowsiness and asthenia are common side effects. There has been a report of hepatitis caused by clotiazepam. Clotiazepam is a ...
This syndrome is often accompanied by asthenia. Alain Carpentier - a member of the French Academy of Sciences and the head the ... It is used to treat Skumin syndrome, light forms of heart failure, anxiety and sleep disorders, and asthenia. The medicine is ...
At the initial stage, asthenia is prevalent and the progress of the disorder is slow. Acute onset can be diagnosed when a large ... Psychoorganic syndrome is often accompanied by asthenia. Psychoorganic syndrome occurs during atrophy of the brain, most ...
A marked increase in fatigability, or asthenia, is often prominent. This increased weariness may be combined with hyperactivity ... and profound fatigue or asthenia chiefly characterizes the picture. Erratic behaviour may include intermittent rage disorder ...
... is the stallion that is linked to the genetic disease Hereditary Equine Regional Dermal Asthenia (HERDA) in stock ... Inheritance of hereditary equine regional dermal asthenia in Quarter Horses. Vet Dermatol. 2004 Aug;15(4):207-17. Hereditary ... equine regional dermal asthenia ("hyperelastosis cutis") in 50 horses Lab Invest. 1988 Aug;59(2):253-62. An inherited ...
Main therapeutic areas: Cough & Cold, GERD & Heartburn, Antiviral, Asthenia and Vitamins. Contract Manufacturing Unit: - ...
These symptoms could consist of asthenia, fever, anorexia, and weight loss. It mostly occurs during a severe disease flare. ...
The symptoms may be aspecific: asthenia, pallor, fever, dizziness and respiratory symptoms. More specific symptoms are bruises ...
Weakness or asthenia is a symptom of a number of different conditions. Weakness may also refer to: Muscle weakness, the ...
Chronic campylobacteriosis features a long period of sub-febrile temperature and asthenia; eye damage, arthritis, endocarditis ...
... other potential causes of proteinuria include asthenia, weight loss or bone pain. In diabetes mellitus there is an association ...
Gastro-intestinal (GI) effects and asthenia are the most common adverse events. Green tea extract epigallocatechin gallate ( ...
... is used to treat asthenia (symptoms of fatigue or weakness) in France. It is not clear if it effective. Adverse ...
Subjective measures include scales such as the Grade, Roughness, Breathiness, Asthenia, Strain Scale (GRBAS); the Reflux ...
Asthenia. ?. Medically reviewed by Modern Weng, D.O. on March 9, 2016. - Written by April Kahn ...
... humans Hereditary equine regional dermal asthenia - horses Feline cutaneous asthenia - cats Maudlin, EA; Peters-Kennedy, J ( ... Cutaneous asthenia is a skin disorder caused by a collagen defect. Collagen is the protein that binds the cells of the dermis ...
Hypsioma asthenia is a species of beetle in the family Cerambycidae. It was described by Martins and Galileo in 1990. It is ... BioLib.cz - Hypsioma asthenia. Retrieved on 8 September 2014.. ...
Treatments and Tools for asthenia. Find asthenia information, treatments for asthenia and asthenia symptoms. ... asthenia - MedHelps asthenia Center for Information, Symptoms, Resources, ...
ASTHENIA Causes, Patient Concerns and Latest Treatments and Dilaudid Reports and Side Effects. ... Asthenia. assessed with the subscale for fatigue of the Functional Assessment of Cancer Therapy (FACT-F); Intensity of Asthenia ... Check out the latest treatments for ASTHENIA. ➢ ASTHENIA treatment research studies. ➢ Dilaudid clinical trials, surveys and ... ASTHENIA Symptoms and Causes. We are sorry, but no medical information on this topic currently exists in our database. Our ...
... The subject is a timely one when the nervous systems of many executives and business men are ...
Where are the diseases of yesteryear? DaCostas syndrome, soldiers heart, the effort syndrome, neurocirculatory asthenia--and ... Where are the diseases of yesteryear? DaCostas syndrome, soldiers heart, the effort syndrome, neurocirculatory asthenia--and ... Where are the diseases of yesteryear? DaCostas syndrome, soldiers heart, the effort syndrome, neurocirculatory asthenia--and ... Where are the diseases of yesteryear? DaCostas syndrome, soldiers heart, the effort syndrome, neurocirculatory asthenia--and ...
Find out information about Asthenia. Loss or lack of strength. , a condition of illness manifested by excessive fatigue and ... exhaustion accompanied by extreme instability of mood, weakened... Explanation of Asthenia ... Asthenia. Also found in: Dictionary, Thesaurus, Medical, Legal, Wikipedia.. Related to Asthenia: neurocirculatory asthenia ... The symptoms of asthenia are characteristic of the early stages of schizophrenia. Defining the characteristics of asthenia ...
Methods: The short-term and long-term rat models of spleen-asthenia syndrome(RMSA I and RMSA II group) were treated by ... The synthetic and secretory function of the enteroendocrinr cells varyed with the development of spleen-asthenia syndrome. ... Methods: The short-term and long-term rat models of spleen-asthenia syndrome(RMSA I and RMSA II group) were treated by ... Experimental Study on Changes of Enteroendocrine Cells of Somatostain, Motilin and Cholecystokinin in Splenic Asthenia Rat ...
... asthenia explanation free. What is asthenia? Meaning of asthenia medical term. What does asthenia mean? ... Looking for online definition of asthenia in the Medical Dictionary? ... Kinds of asthenia include myalgic asthenia and neurocirculatory asthenia. See also adynamia. asthenic, adj. ... Related to asthenia: neurocirculatory asthenia. asthenia. [as-the´ne-ah] debility; loss of strength and energy; weakness. adj ...
Antonyms for neurocirculatory asthenia. 1 synonym for asthenia: astheny. What are synonyms for neurocirculatory asthenia? ... asthenia. (redirected from neurocirculatory asthenia). Also found in: Dictionary, Medical, Acronyms, Encyclopedia.. Related to ... Neurocirculatory asthenia synonyms, neurocirculatory asthenia antonyms - FreeThesaurus.com https://www.freethesaurus.com/ ... asthenia,FreeThesaurus.com,/a,,/div, ,!--End of Graphic Thesaurus by FreeThesaurus.com--,. The code for attribution links is ...
Asthenia - see debility. Atrophy - Wasting away or diminishing in size. Bad Blood - Syphilis. Bilious fever - A term loosely ... Synonym: asthenia. Decrepitude - Feebleness due to old age. Delirium tremens - aka DTs; hallucination due to alcoholism. Dengue ...
Asthenia is the medical term used to mean fatigue. It is a vague term because fatigue is very difficult to measure. On the ... Treatment of Asthenia. The treatment of asthenia depends on its cause. It can be medicated in case of infection, hormonal ... Definition of Asthenia. The word "Asthenia" comes from the Greek "sthenos" (force, vigor), and has an a-privative. It would ... Causes of Asthenia. A large number of pathologies can cause asthenia. We distinguish organic causes (diseases), functional and ...
Neurocirculatory Asthenia Symptom Checker: Possible causes include Anemia & Morbid Obesity & Obesity. Check the full list of ... The cardiovascular manifestations of neurocirculatory asthenia.[mgwater.com] Neurocirculatory asthenia (anxiety neurosis, ... patients with primary neurocirculatory asthenia had a much better prognosis than those with secondary neurocirculatory asthenia ... asthenia neurosis (stuttering glossary) psychasthenia Resources Books, etc.[behavenet.com] […] by felt anxiety or related ...
Asthenia. Asthenia refers to lack of muscle strength and extreme debility. A healthy lifestyle and early diagnosis can help ...
Asthenia. Asthenia refers to lack of muscle strength and extreme debility. A healthy lifestyle and early diagnosis can help ...
Asthenia, Fatigue, Malaise, Dysgeusia And Dizziness. *Events of asthenia, fatigue, malaise, dysgeusia and dizziness were mainly ...
Asthenia, Electrolyte Imbalance, Night Sweats Symptom Checker: Possible causes include Hyperthyroidism, Stroke, Metastatic ... Differential diagnoses, possible causes and diseases for Asthenia, Electrolyte Imbalance, Night Sweats listed by probability ... asthenia, and weight loss) (16,17).[scielo.isciii.es] A patient who has malabsorption or a lot of diarrhea may lose fluids and ... Gr III asthenia.[ncbi.nlm.nih.gov] In this context, constitutive symptoms like fever, night sweats and weight loss may be ...
Asthenia (Greek asthenes, without strength) is a very common symptom and several patients from my group complained of symptoms ... As we know, asthenia may have different causes but is commonly associated with chronic pain, depression, sleep disorders, ... Asthenia (Greek asthenes, without strength) is a very common symptom and several patients from my group complained of symptoms ... 7.8 Cluster of points with low ESR in 30 subjects suffering from asthenia on the left; cluster of tender points with PPT of the ...
Common causes of Asthenia include the following:. Lifestyle. Sedentary lifestyle is among the common cause of Asthenia. A ... Various factors and causes can result to the onset of Asthenia. Asthenia is generally caused by a lot of conditions that can ... The symptoms of Asthenia depend on the area affected whether it affects the body as a whole or affects a part of the body only ... Asthenia leads to the inability to perform or finish a task although a certain task can be initiated except that there is ...
Asthenia (General Weakness). General weakness (asthenia) is often a component of fatigue. Symptoms may affect physical, ...
Cutaneous asthenia (literally, weak skin) is part of a group of hereditary disorders characterized by skin that is unusually ... Cutaneous Asthenia in Dogs. Cutaneous asthenia (literally, weak skin) is part of a group of hereditary disorders characterized ... This condition is incurable, and the prognosis for cutaneous asthenia is not good. Many dog owners choose to euthanize in ... asthenia. Lack of strength in the body; weakness; inability to perform excessive amounts of work. ...
Asthenia, Fatigue, Malaise, Dysgeusia And Dizziness. Events of asthenia, fatigue, malaise, dysgeusia and dizziness were mainly ...
Reports of the adverse drug reaction known as amodiaquine-associated asthenia are scarce, and this adverse reaction needs to be ... This article presents and reviews a case of amodiaquine-associated asthenia. A literature search for the characteristics of ... Methods: A case of probable amodiaquine asthenia was described and discussed under the sub-headings of epidemiology, clinical ... The frequency of amodiaquine-associated asthenia in different populations ranged from 12-36%. There is a paucity of reports, ...
  • tropical anhidrotic asthenia a rare condition occurring under conditions of heat stress, in which miliaria causes extensive occlusion of the sweat ducts producing anhidrosis and heat retention that may lead to weakness, dyspnea, tachycardia, elevation of body temperature, and collapse. (thefreedictionary.com)
  • Asthenia is the medical term for the condition known as weakness. (aboutbfs.com)
  • Asthenia or weakness is defined as a reduced strength which makes it difficult for an affected individual to be able to perform or finish a task. (aboutbfs.com)
  • Asthenia is generally caused by a lot of conditions that can trigger weakness or loss of strength in exerting a force to achieve a certain movement or task. (aboutbfs.com)
  • General weakness (asthenia) is often a component of fatigue. (myeloma.org)
  • [ncbi.nlm.nih.gov] One dose-limiting toxicity (DLT) was reported at DL 0: grade (Gr) III diarrhoea and one DLT at DL 2: Gr III asthenia . (symptoma.com)
  • Asthenia refers to a feeling of generalized fatigue, disproportionate and without any apparent reason. (mediologiest.com)
  • The Anti-asthenia treatment (containing vitamins, amino acids, trace elements) are recommended when the fatigue is commonplace due to occupational fatigue, family, examinations or competitions and that no organic cause is found. (mediologiest.com)
  • Several complementary approaches make it possible to fight against asthenia when it comes to ordinary fatigue without underlying disease. (mediologiest.com)
  • Possible reasons for asthenia/chronic fatigue? (drugs-forum.com)
  • Hi all, I want to know what is the cause and potential fix for my asthenia / fatigue related problems I'm having. (drugs-forum.com)
  • A 20-year-old woman, with no history of medical problems, was admitted to the hospital on February 4, 2002, with a 3-week history of asthenia , myalgia, low-grade fever, urinary retention, and blurred vision. (thefreedictionary.com)
  • tropical anhidrotic asthenia a condition due to generalized anhidrosis in conditions of high temperature, characterized by a tendency to overfatigability, irritability, anorexia, inability to concentrate, and drowsiness, with headache and vertigo. (thefreedictionary.com)
  • Methods: The short-term and long-term rat models of spleen-asthenia syndrome(RMSA I and RMSA II group) were treated by reserpine for seven days and fourteen days respectively. (cnki.com.cn)
  • Conclusion: The synthetic and secretory function of the enteroendocrinr cells varyed with the development of spleen-asthenia syndrome. (cnki.com.cn)
  • To identify serum biomarker that could help to diagnose and treat splenic asthenia and phlegm-damp syndrome (SAPDS) of non-small-cell lung cancer (NSCLC). (currentscience.org)
  • Asthenia produced by nervous exhaustion, emotional upset, or difficult, usually prolonged, emotional strain or conflict is known as neurasthenia. (thefreedictionary.com)
  • With the use of amodiaquine as a partner drug in antimalarial combination therapies being scaled up, well-structured studies are needed on adverse reactions to amodiaquine and to investigate amodiaquine-associated asthenia. (ijtmgh.com)
  • The word "Asthenia" comes from the Greek "sthenos" (force, vigor), and has an a-privative. (mediologiest.com)
  • Asthenia may appear in the early stages of a disease of the internal organs-for example, a coronary-or it may accompany this type of illness as one of its manifestations-as in ulcers, tuberculosis, and other chronic diseases. (thefreedictionary.com)
  • The manifestations of asthenia depend on the basic illness that caused it. (thefreedictionary.com)
  • TCM could also be cited for this area because asthenia with depression and chronic pain, often reported by my middle-aged patients, particularly females, could imply a deficiency of Yin/ Yang Kidney. (doctorabel.us)
  • Tropical anhidrotic asthenia results from the inability to sweat over large areas of skin following PRICKLY HEAT . (thefreedictionary.com)
  • Asthenia leads to the inability to perform or finish a task although a certain task can be initiated except that there is difficulty due to a reduction or loss in the overall strength. (aboutbfs.com)
  • It is more of a symptom rather than a condition itself although Asthenia is generally non-life threatening but can affect the quality of life. (aboutbfs.com)
  • Infection is also seen as one of the common cause of Asthenia. (aboutbfs.com)
  • IMSEAR at SEARO: Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia. (who.int)
  • and moderate asthenia in 94 (5.3, 0-17.6). (who.int)
  • Defining the characteristics of asthenia often helps in the recognition of the basic illness causing it. (thefreedictionary.com)
  • Asthenia can occur to anyone regardless of age and gender and without racial predilection. (aboutbfs.com)
  • Sedentary lifestyle is among the common cause of Asthenia. (aboutbfs.com)
  • Advancement in age or aging is also considered as one of the most common cause of Asthenia. (aboutbfs.com)