Aspergillus nidulans: A species of imperfect fungi from which the antibiotic nidulin is obtained. Its teleomorph is Emericella nidulans.Aspergillus: A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.Aspergillus fumigatus: A species of imperfect fungi from which the antibiotic fumigatin is obtained. Its spores may cause respiratory infection in birds and mammals.Aspergillus niger: An imperfect fungus causing smut or black mold of several fruits, vegetables, etc.Aspergillus flavus: A species of imperfect fungi which grows on peanuts and other plants and produces the carcinogenic substance aflatoxin. It is also used in the production of the antibiotic flavicin.Fungal Proteins: Proteins found in any species of fungus.Spores, Fungal: Reproductive bodies produced by fungi.Sterigmatocystin: A carcinogenic mycotoxin produced in high yields by strains of the common molds, Aspergillus versicolor, A. nidulans, and an unidentified species of Bipolaris. It causes necrosis of the liver and kidney and has an inhibitory effect on orotic acid incorporation into nuclear RNA.Genes, Fungal: The functional hereditary units of FUNGI.Gene Expression Regulation, Fungal: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.Aspergillosis: Infections with fungi of the genus ASPERGILLUS.Hyphae: Microscopic threadlike filaments in FUNGI that are filled with a layer of protoplasm. Collectively, the hyphae make up the MYCELIUM.Benomyl: A systemic agricultural fungicide used for control of certain fungal diseases of stone fruit.DNA, Fungal: Deoxyribonucleic acid that makes up the genetic material of fungi.Reproduction, Asexual: Reproduction without fusion of two types of cells, mostly found in ALGAE; FUNGI; and PLANTS. Asexual reproduction occurs in several ways, such as budding, fission, or splitting from "parent" cells. Only few groups of ANIMALS reproduce asexually or unisexually (PARTHENOGENESIS).Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Penicillium chrysogenum: A mitosporic fungal species used in the production of penicillin.Aflatoxins: Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.Transformation, Genetic: Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Penicillium: A mitosporic Trichocomaceae fungal genus that develops fruiting organs resembling a broom. When identified, teleomorphs include EUPENICILLIUM and TALAROMYCES. Several species (but especially PENICILLIUM CHRYSOGENUM) are sources of the antibiotic penicillin.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Gene Deletion: A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.Isomaltose: A disaccharide consisting of two glucose units in an alpha (1-6) glycosidic linkage.Aspergillus oryzae: An imperfect fungus present on most agricultural seeds and often responsible for the spoilage of seeds in bulk storage. It is also used in the production of fermented food or drink, especially in Japan.Aspergillus ochraceus: An imperfect fungus that produces ochratoxins and contaminates EDIBLE GRAIN and coffee beans.Quinic Acid: An acid which is found in cinchona bark and elsewhere in plants. (From Stedman, 26th ed)Genetic Complementation Test: A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.Fungi: A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.Chitin Synthase: An enzyme that converts UDP glucosamine into chitin and UDP. EC 2.4.1.16.Mitosis: A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.Diploidy: The chromosomal constitution of cells, in which each type of CHROMOSOME is represented twice. Symbol: 2N or 2X.Acetate-CoA Ligase: An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.Mycotoxins: Toxic compounds produced by FUNGI.RNA, Fungal: Ribonucleic acid in fungi having regulatory and catalytic roles as well as involvement in protein synthesis.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Homogentisate 1,2-Dioxygenase: A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.Cell Wall: The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.Genome, Fungal: The complete gene complement contained in a set of chromosomes in a fungus.Mycelium: The body of a fungus which is made up of HYPHAE.Nitrate Reductases: Oxidoreductases that are specific for the reduction of NITRATES.Suppression, Genetic: Mutation process that restores the wild-type PHENOTYPE in an organism possessing a mutationally altered GENOTYPE. The second "suppressor" mutation may be on a different gene, on the same gene but located at a distance from the site of the primary mutation, or in extrachromosomal genes (EXTRACHROMOSOMAL INHERITANCE).Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Haploidy: The chromosomal constitution of cells, in which each type of CHROMOSOME is represented once. Symbol: N.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Pulmonary Aspergillosis: Infections of the respiratory tract with fungi of the genus ASPERGILLUS. Infections may result in allergic reaction (ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS), colonization in pulmonary cavities as fungus balls (MYCETOMA), or lead to invasion of the lung parenchyma (INVASIVE PULMONARY ASPERGILLOSIS).Hydro-Lyases: Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.Drug Resistance, Fungal: The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.Penicillins: A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)Enzyme Repression: The interference in synthesis of an enzyme due to the elevated level of an effector substance, usually a metabolite, whose presence would cause depression of the gene responsible for enzyme synthesis.Gliotoxin: A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.Aspergillosis, Allergic Bronchopulmonary: Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.Genes, Regulator: Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.Chromosomes, Fungal: Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Oxidoreductases: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)

Expression of atrC - encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans - is sensitive to cycloheximide. (1/1128)

A new member of the ABC superfamily of transmembrane proteins in Aspergillus nidulans has been cloned and characterized. The topology of conserved motifs subgroups AtrC in the P-glycoprotein cluster of ABC permeases, the members of this subfamily, are known to participate in multidrug resistance (MDR) in diverse organisms. Alignment results display significant amino acid similarity to AfuMDR1 and AflMDR1 from Aspergillus fumigatus and flavus, respectively. Northern analysis reveals that atrC mRNA levels are 10-fold increased in response to cycloheximide. Evidence for the existence of eight additional hitherto unpublished ABC transporter proteins in A. nidulans is provided.  (+info)

Insertion analysis of putative functional elements in the promoter region of the Aspergillus oryzae Taka-amylase A gene (amyB) using a heterologous Aspergillus nidulans amdS-lacZ fusion gene system. (2/1128)

Expression of the Taka-amylase A gene (amyB) of Aspergillus oryzae is induced by starch or maltose. The A. oryzae amyB gene promoter contains three highly conserved sequences, designated Regions I, II, and III, compared with promoter regions of the A. oryzae glaA encoding glucoamylase and the agdA encoding alpha-glucosidase. To identify the function of these sequences within the amyB promoter, various fragments containing conserved sequences in the amyB promoter were introduced into the upstream region of the heterologous A. nidulans amdS gene (encoding acetamidase) fused to the Escherichia coli lacZ gene as a reporter. Introduction of the sequence between -290 to -233 (the number indicates the distance in base pairs from the translation initiation point (+1)) containing Region III significantly increased the expression of the lacZ reporter gene in the presence of maltose. The sequence between -377 to -290 containing Region I also increased the lacZ activity, but its maltose inducibility was less than that of Region III. The sequence between -233 to -181 containing Region II had no effect on the expression. These results indicated that Region III is most likely involved in the maltose induction of the amyB gene expression.  (+info)

The GATA factor AreA is essential for chromatin remodelling in a eukaryotic bidirectional promoter. (3/1128)

The linked niiA and niaD genes of Aspergillus nidulans are transcribed divergently. The expression of these genes is subject to a dual control system. They are induced by nitrate and repressed by ammonium. AreA mediates derepression in the absence of ammonium and NirA supposedly mediates nitrate induction. Out of 10 GATA sites, a central cluster (sites 5-8) is responsible for approximately 80% of the transcriptional activity of the promoter on both genes. We show occupancy in vivo of site 5 by the AreA protein, even under conditions of repression. Sites 5-8 are situated in a pre-set nucleosome-free region. Under conditions of expression, a drastic nucleosomal rearrangement takes place and the positioning of at least five nucleosomes flanking the central region is lost. Remodelling is strictly dependent on the presence of an active areA gene product, and independent from the NirA-specific and essential transcription factor. Thus, nucleosome remodelling is independent from the transcriptional activation of the niiA-niaD promoter. The results presented cast doubts on the role of NirA as the unique transducer of the nitrate induction signal. We demonstrate, for the first time in vivo, that a GATA factor is involved directly in chromatin remodelling.  (+info)

Unique DNA binding specificity of the binuclear zinc AlcR activator of the ethanol utilization pathway in Aspergillus nidulans. (4/1128)

AlcR is the transcriptional activator in Aspergillus nidulans, necessary for the induction of the alc gene cluster. It belongs to the Zn2Cys6 zinc cluster protein family, but contains some striking differences compared with other proteins of this group. In this report, we show that no dimerization element is present in the entire AlcR protein which occurs in solution as a monomer and binds also to its cognate sites as a monomer. Another important feature of AlcR is its unique specificity for single sites occurring naturally as inverted or direct repeats and sharing a common motif, 5'-(T/A)GCGG-3'. Like most other Zn2Cys6 proteins, AlcR contacts directly with the CGG triplet and, in addition, the upstream adjacent guanine is required for high affinity binding. We also establish that the flanking regions outside the core play an essential role in tight binding. From our in vitro analysis, we propose an optimal AlcR-binding site which is 5'-PuNGCGG-AT rich 3'.  (+info)

nimO, an Aspergillus gene related to budding yeast Dbf4, is required for DNA synthesis and mitotic checkpoint control. (5/1128)

The nimO predicted protein of Aspergillus nidulans is related structurally and functionally to Dbf4p, the regulatory subunit of Cdc7p kinase in budding yeast. nimOp and Dbf4p are most similar in their C-termini, which contain a PEST motif and a novel, short-looped Cys2-His2 zinc finger-like motif. DNA labelling and reciprocal shift assays using ts-lethal nimO18 mutants showed that nimO is required for initiation of DNA synthesis and for efficient progression through S phase. nimO18 mutants abrogated a cell cycle checkpoint linking S and M phases by segregating their unreplicated chromatin. This checkpoint defect did not interfere with other checkpoints monitoring spindle assembly and DNA damage (dimer lesions), but did prevent activation of a DNA replication checkpoint. The division of unreplicated chromatin was accelerated in cells lacking a component of the anaphase-promoting complex (bimEAPC1), consistent with the involvement of nimO and APC/C in separate checkpoint pathways. A nimO deletion conferred DNA synthesis and checkpoint defects similar to nimO18. Inducible nimO alleles lacking as many as 244 C-terminal amino acids supported hyphal growth, but not asexual development, when overexpressed in a ts-lethal nimO18 strain. However, the truncated alleles could not rescue a nimO deletion, indicating that the C terminus is essential and suggesting some type of interaction among nimO polypeptides.  (+info)

The abfB gene encoding the major alpha-L-arabinofuranosidase of Aspergillus nidulans: nucleotide sequence, regulation and construction of a disrupted strain. (6/1128)

Using a DNA fragment containing the Aspergillus niger abfB gene as a probe, the homologous Aspergillus nidulans gene, designated abfB, has been cloned from a genomic library containing size-selected HindIII fragments. The nucleotide sequence of the A. nidulans abfB gene shows strong homology with the A. niger abfB, Trichoderma reesei abf-1 and Trichoderma koningii alpha-L-arabinofuranosidase/beta-xylosidase genes. Regulation of abfB expression has been investigated in cultures induced with L-arabitol. The accumulation of abfB mRNA, total alpha-L-arabinofuranosidase activity and AbfB protein levels have been determined in a wild-type A. nidulans strain as well as in different mutant strains. These strains are affected either in their response to ambient pH (paIA1 and pacC(c)14 mutants), carbon catabolite repression (creA(d)4 mutant), the ability to utilize L-arabitol as a carbon source (araA1 mutant) or a combination of both latter genotypes (araA1 creA(d)4). The results obtained indicate that the expression of the A. nidulans abfB gene was higher at acidic pHs and was superinduced in this double mutant. Furthermore, disruption of the abfB gene demonstrated that in A. nidulans AbfB is the major p-nitrophenyl alpha-L-arabinofuranoside-hydrolysing activity but at least one minor activity is expressed, which is involved in the release of L-arabinose from polysaccharides.  (+info)

Zinc-regulated biosynthesis of immunodominant antigens from Aspergillus spp. (7/1128)

ASPND1 and ASPF2 are immunodominant antigens from Aspergillus nidulans and A. fumigatus, respectively, that are readily synthesized in infections in the human host, as demonstrated by their reactivity with more than 80% of sera from patients with aspergilloma or allergic bronchopulmonary aspergillosis. We demonstrate here that both antigens are exclusively produced under situations of low bioavailability of free Zn2+. Addition of micromolar concentrations of Zn2+ to the culture medium strongly stimulated Aspergillus growth but totally inhibited ASPND1 or ASPF2 production. This effect was specific, since other divalent metals had no effect. Removal of endogenous Zn2+ by a chelator also stimulated ASPND1 production, and the effect was specifically reversed by Zn2+. These results suggest a possible role of these antigens in the survival of the fungus in the lungs.  (+info)

Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction. (8/1128)

Aspergillus nidulans utilizes phenylacetate as a carbon source via homogentisate, which is degraded to fumarate and acetoacetate. Mutational evidence strongly suggested that phenylacetate is converted to homogentisate through two sequential hydroxylating reactions in positions 2 and 5 of the aromatic ring. Using cDNA substraction techniques, we have characterized a gene, denoted phacA, whose transcription is strongly induced by phenylacetate and which putatively encodes a cytochrome P450 protein. A disrupted phacA strain does not grow on phenylacetate but grows on 2-hydroxy- or 2, 5-dihydroxyphenylacetate. Microsomal extracts of the disrupted strain are deficient in the NADPH-dependent conversion of phenylacetate to 2-hydroxyphenylacetate. We conclude that PhacA catalyzes the ortho-hydroxylation of phenylacetate, the first step of A. nidulans phenylacetate catabolism. The involvement of a P450 enzyme in the ortho-hydroxylation of a monoaromatic compound has no precedent. In addition, PhacA shows substantial sequence divergence with known cytochromes P450 and defines a new family of these enzymes, suggesting that saprophytic fungi may represent a source of novel cytochromes P450. Phenylacetate is a precursor for benzylpenicillin production. phacA disruption increases penicillin production 3-5-fold, indicating that catabolism competes with antibiotic biosynthesis for phenylacetate and strongly suggesting strategies for Penicillium chrysogenum strain improvement by reverse genetics.  (+info)

O-glycosylation has been considered a limiting factor in protein secretion in filamentous fungi. Overexpression of the yeast DPM1 gene encoding dolichylphosphate mannose synthase (DPMS) in an Aspergillus nidulans mutant (BWB26A) deficient in O-glycosylation caused an increase in the number of secretory vesicles and changes in protein secretion. However, the secretory proteins, primarily O-mannosylated glucoamylase and N-glycosylated invertase, were mainly trapped in the periplasmic space. Different glycoforms of invertase were found insite the cells, in the periplasmic space and in the cultivation medium. Our data point to the importance of the cell wall as a barrier in protein secretion ...
TY - JOUR. T1 - Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. AU - Nuetzmann, Hans-Wilhelm. AU - Reyes-Dominguez, Yazmid. AU - Scherlach, Kirstin. AU - Schroeckh, Volker. AU - Horn, Fabian. AU - Gacek, Agnieszka. AU - Schümann, Julia. AU - Hertweck, Christian. AU - Strauss, Joseph. AU - Brakhage, Axel A. PY - 2011/8/23. Y1 - 2011/8/23. N2 - Sequence analyses of fungal genomes have revealed that the potential of fungi to produce secondary metabolites is greatly underestimated. In fact, most gene clusters coding for the biosynthesis of antibiotics, toxins, or pigments are silent under standard laboratory conditions. Hence, it is one of the major challenges in microbiology to uncover the mechanisms required for pathway activation. Recently, we discovered that intimate physical interaction of the important model fungus Aspergillus nidulans with the soil-dwelling bacterium Streptomyces rapamycinicus specifically ...
The biosynthesis of the beta-lactam antibiotic penicillin in the filamentous fungus Aspergillus nidulans is catalyzed by three enzymes that are encoded by the acvA, ipnA, and aatA genes. A variety of cis-acting DNA elements and regulatory factors form a complex regulatory network controlling these beta-lactam biosynthesis genes. Regulators involved include the CCAAT-binding complex AnCF and AnBH1. AnBH1 acts as a repressor of the penicillin biosynthesis gene aatA. Until now, however, little information has been available on the signal transduction cascades leading to the transcription factors. Here we show that inhibition of protein kinase C (Pkc) activity in A. nidulans led to cytoplasmic localization of an AnBH1-enhanced green fluorescent protein (EGFP) fusion protein. Computer analysis of the genome and screening of an A. nidulans gene library revealed that the fungus possesses two putative Pkc-encoding genes, which we designated pkcA and pkcB. Only PkcA showed all the characteristic features ...
Hyphal tip growth in fungi is important because of the economic and medical importance of fungi, and because it may be a useful model for polarized growth in other organisms. We have investigated the central questions of the roles of cytoskeletal elements and of the precise sites of exocytosis and endocytosis at the growing hyphal tip by using the model fungus Aspergillus nidulans. Time-lapse imaging of fluorescent fusion proteins reveals a remarkably dynamic, but highly structured, tip growth apparatus. Live imaging of SYNA, a synaptobrevin homologue, and SECC, an exocyst component, reveals that vesicles accumulate in the Spitzenkörper (apical body) and fuse with the plasma membrane at the extreme apex of the hypha. SYNA is recycled from the plasma membrane by endocytosis at a collar of endocytic patches, 1-2 μm behind the apex of the hypha, that moves forward as the tip grows. Exocytosis and endocytosis are thus spatially coupled. Inhibitor studies, in combination with observations of ...
1 Adams, T. H., Wieser, J. K., & Yu, J.-H. (1998). Asexual Sporulation in Aspergillus nidulans. Microbiology and Molecular Biology Reviews, 62(2), 545-545. doi: 10.1128/mmbr.62.2.545-545.1998 https://mmbr.asm.org/content/62/1/35.full 2 David, H., Özçelik, I. Ş., Hofmann, G., & Nielsen, J. (2008). Analysis of Aspergillus nidulans metabolism at the genome-scale. BMC Genomics, 9(1), 163. doi: 10.1186/1471-2164-9-163 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386489/ 3 Galagan JE; et al. (2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 (7071): 1105-15. doi:10.1038/nature04341. PMID 16372000. https://www.ncbi.nlm.nih.gov/pubmed/16372000 4 Gugnani, H. C. (2003). Ecology and taxonomy of pathogenic aspergilli. Frontiers in Bioscience, 8(6). doi: 10.2741/1002 ...
1 Adams, T. H., Wieser, J. K., & Yu, J.-H. (1998). Asexual Sporulation in Aspergillus nidulans. Microbiology and Molecular Biology Reviews, 62(2), 545-545. doi: 10.1128/mmbr.62.2.545-545.1998 https://mmbr.asm.org/content/62/1/35.full 2 David, H., Özçelik, I. Ş., Hofmann, G., & Nielsen, J. (2008). Analysis of Aspergillus nidulans metabolism at the genome-scale. BMC Genomics, 9(1), 163. doi: 10.1186/1471-2164-9-163 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386489/ 3 Galagan JE; et al. (2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 (7071): 1105-15. doi:10.1038/nature04341. PMID 16372000. https://www.ncbi.nlm.nih.gov/pubmed/16372000 4 Gugnani, H. C. (2003). Ecology and taxonomy of pathogenic aspergilli. Frontiers in Bioscience, 8(6). doi: 10.2741/1002 ...
In this study, several aspects of nitrate assimilation and transport have been studied using the filamentous fungus Aspergillus nidulans, which has been shown to be safe laboratory organism as judged by its pathogenicity towards insect larvae. In silico analysis of the A. nidulans genome sequence, identified two putative genes designated cnxL and cnxK that might be involved in molybdenum cofactor (a component of nitrate reductase) biosynthesis as well as two putative nitrate reductases encoding genes niaB and niaC. All four genes are hitherto unknown. Although many features of these proteins provided clues of functionality, biochemical and genetical approaches employed in this present study failed to elicit expression of any of these four genes. A NrtA protein structure model was developed based on residue homology with the E. coli GlpT a protein, the structure of which has been solved. The results of thiol cross-linking of three double cysteine mutants in four NrtA essential residues, R87, ...
TY - JOUR. T1 - The Aspergillus nidulans snt genes are required for the regulation of septum formation and cell cycle checkpoints. AU - Kraus, Peter R.. AU - Harris, Steven D.. PY - 2001/11/17. Y1 - 2001/11/17. N2 - In Aspergillus nidulans, germinating conidia undergo multiple rounds of nuclear division before forming a septum. Previous genetic results suggest that the ability to separate nuclear division and septum formation depends upon a threshold level of activity of the cyclin-dependent kinase NIMX,cdk1. Mutations in nimX and nimT, the gene encoding the NIMXcdk1-activating phosphatase, have revealed that Tyr-15 phosphorylation is important for determining the timing of the formation of the first septum. Here, we describe a screen for suppressors of nimT23 (snt), designed to identify additional components of the pathway regulating septum formation. We show that a subset of the snt mutants are defective in the temporal regulation of septum formation and in cell cycle checkpoint responses. ...
The filamentous fungus Aspergillus nidulans senses red using the red light receptor, phytochrome (FphA). In this study, we identified the MAP kinase SakA (also known as HogA) was involved in phytochrome-dependent light sensing by an efficient screening approach. FphA physically interacted with the histidine-containing phosphotransferase (HPt), YpdA in the cytoplasm. Light activation of the SakA pathway depended on FphA. Hence, light plugs into the SakA pathway through phytochrome ...
TY - JOUR. T1 - Analysis of ambient pH stress response mediated by iron and copper intake in Schizosaccharomyces pombe. AU - Higuchi, Yujiro. AU - Mori, Hikari. AU - Kubota, Takeo. AU - Takegawa, Kaoru. PY - 2018/1/1. Y1 - 2018/1/1. N2 - The molecular mechanism of tolerance to alkaline pH is well studied in model fungi Aspergillus nidulans and Saccharomyces cerevisiae. However, how fission yeast Schizosaccharomyces pombe survives under alkaline stress remains largely unknown, as the genes involved in the alkaline stress response pathways of A. nidulans and S. cerevisiae were not found in the genome of this organism. Since uptake of iron and copper into cells is important for alkaline tolerance in S. cerevisiae, here we examined whether iron and copper uptake processes were involved in conferring tolerance to alkaline stress in S. pombe. We first revealed that S. pombe wild-type strain could not grow at a pH higher than 6.7. We further found that the growths of mutants harboring disruption in the ...
Aspergilli represent an extremely important genus of microorganisms which can be both harmful pathogens, and beneficial pharmaceutical producers. In Aspergillis interactions with man, suboptimal nutrient conditions are often present, and lead to a phenomenon known as autophagy. Autophagy is a cellular recycling mechanism that (in the case of macroautophagy) is augmented under nutrient limited conditions to recycle cytoplasmic macromolecules and organelles for use in essential cell functions. Strategic manipulation of autophagy could ultimately lead to improved bioprocesses or anti-fungal treatments. Using the model filamentous fungus Aspergillus nidulans, a number of important questions about autophagy have been addressed.. Critical to the study of autophagy is the balance between self-degradation and self-preservation. Therefore, we adapted an XTT metabolic activity assay for use in filamentous fungi. The assay was first tested using a number of bioprocess related stresses (e.g. temperature, ...
Conidiation in the filamentous ascomycete Aspergillus nidulans requires activation of brlA, a well-characterized transcriptional regulator of genes that are induced specifically during asexual develop
Entry into mitosis in Aspergillus nidulans is regulated by the coordinate function of two serine/threonine protein kinases, NIMXCDC2 and NIMA. NIMXCDC2 is an essential histone H1 kinase that is structurally and functionally homologous to fission yeast p34cdc2 (Osmani et al., 1994). NIMA is a β-casein kinase and is structurally distinct from p34cdc2, containing an amino-terminal catalytic domain and a carboxyl-terminal regulatory domain (Osmani et al., 1988b; Lu et al., 1993; Pu and Osmani, 1995; Pu et al., 1995). Failure to properly activate either of these kinases in G2 prevents the initiation of mitosis, and the combined action of both kinases is critical for coordinating changes in chromosome, microtubule, and nuclear membrane structure during mitosis. For example, mutations preventing the activation of NIMXCDC2 in G2 normally arrests cells in late G2 (Osmani et al., 1991a; 1994). Although overexpression of NIMA can overcome this interphase arrest, the ensuing mitosis is disorganized such ...
Summary: A mutation in a gene designated gmdA has been found to lead to loss of ability of Aspergillus nidulans to use benzamide, phenylacetamide and several other amides as sole nitrogen sources for growth. The gmdAI lesion results in low levels of an enzyme, called the general amidase, which has activity for a wide range of amide substrates. This enzyme is repressed by certain nitrogen-containing metabolites, including ammonium, but is probably not regulated by induction or by carbon catabolite repression. Evidence is presented for the general amidase being distinct from the previously characterized acetamidase and formamidase enzymes. The data also indicate that there is a fourth amidase capable of the hydrolysis of valeramide and hexanamide.
TamA interacts with LeuB, the homologue of Saccharomyces cerevisiae Leu3p, to regulate gdhA expression in Aspergillus nidulans Journal Articles Refereed ...
Molecular cloning and expression in Saccharomyces cerevisiae of two Aspergillus nidulans xylanase genes.: Two Aspergillus nidulans genes, xlnA and xlnB, encodin
a haploid strain of the aspergillus nidulans carried the auxotrophic met-eight mutation conferring a requirement for, Hire Biology Expert, Ask Academics Expert, Assignment Help, Homework Help, Textbooks Solutions
PLEASE HELP We are the parents of a nineteen month old Baby Boy with a life threatening disease. To our knowledge this is the first case of a fungal infection of this type known anywhere in the world. If you can provide any suggestions for helpign our little boy we would be most grateful. Infection: Aspergillus Nidulans in the Central Nervous System. The fungus surrounds the base of the brain and is present in other locations on the covering of the meninges. This was diagnosed following a biopsy taken from his lumbar region. Biopsy was taken September 13, 1996. Cause of Infection: Unknown Patients Present Condition: Beginning to show signs of Hydrocephalus. Vomiting is becoming more frequent and fevers and pain are becoming more frequent and severe. He is developing a little trouble walking. Course of Treatment: Began treatment in September on Amphotericin B and 5FC given by IV. Treatment was determined to be unsuccessful. After one month MRI showed disease had progressed. The next treatment ...
Aspergillus nidulans ATCC ® 24766™ Designation: FGSC A158 (ribo1 bi1) Application: Biomedical Research and Development Material
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Microbial steroid biotransformation have found wide-reaching application for the production of more precious and functionalized compounds due to their high regio-and stereoselectivity. In this study, the possibility of using filamentous fungi Aspergillus brasiliensis cells in the biotransformation of progesterone (I), a C-21 steroid hormone was studied for the first time.The fungal strain was inoculated into the transformation medium which supplemented with progesterone as a substrate. Biotransformation of this steroid for 7 days afforded 3 different hydroxylated metabolites: 11α-hydroxyprogesterone (II); 14α-hydroxyprogesterone (III) and 21-hydroxyprogesterone (IV).The metabolites were separated by thin layer chromatography. Structure determinations of the metabolites were performed by comparing NMR, MS and IR spectra of starting compound with those of metabolites.These results may be of industrial importance because the metabolites can be used as precursor of some steroid drugs.
In this paper, we characterized the Dis1/XMAP215 family protein AlpA from A. nidulans and found that it is associated with the MT plus end during mitosis and in interphase. AlpA plays a role in controlling MT dynamics and is important for the determination of growth polarity. Whereas the mechanism of MT stabilization was recently shown in S. cerevisiae (1), a role in polarized growth has not been described before. Polarized growth of filamentous fungi depends on the continuous delivery of secretory vesicles (7, 20). These vesicles provide new membranes and deliver, e.g., enzymes for cell wall biosynthesis. Because the vesicles are generated some distance away from the growing tip, they need to be transported long distances. It is assumed that MTs and conventional kinesin provide the basis for this long-distance transportation (18, 23). The first destination of the vesicles is an organelle close to the apex named the vesicle supply center or Spitzenkörper (8). The location of this organelle ...
Dear David, Ive formulated the concept of a gene module, a set of genes used by more than one step of differentiation, in: Gordon, R. (1995). The Hierarchical Genome and Differentiation Waves: Novel Unification of Development, Genetics, and Evolution (Singapore: World Scientific), in prep. Might this match your clusters? To what extent are you dealing with housekeeping genes? To what extent are they related via gene duplication? Best regards, -Dick Gordon, U.Manitoba[May19,95] On 18 May 1995, David H. Griffin wrote: , Is anyone looking at the evolution of genome organization, specifically , clustering of genes with related functions. This has been reported , frequently among fungi, but these clusters are not always universal, , for example the proline genes of Aspergillus nidulans are clustered but , those of Saccharomyces cerevisiae are not. Is gene clustering of , physiologically related genes common amongst other organisms than , fungi? Any examples with references, or at least ...
per liter NaNO3 6.0 gm KC1 0.52 gm MgSO4. 7H20 0.52 gm KH2PO4 1.52 gm Adjust pH to ca 6.5 (usually requires 1 ml of 1 N NaOH) (Note: If large quantities of minimal are to be used a 2OX stock solution of the above salts can be prepared.) glucose (dextrose) 10.0 gms 2 ml of Hutners trace elements For agar add 15.0 gms Difco Agar ...
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An endo-1,5-arabinanase (abnA) encoding gene from Aspergillus niveus was identified, cloned and successfully expressed in Aspergillus nidulans strain A773. Based on amino acid sequence comparison, the 34-kDa enzyme could be assigned to CAZy GH family 43. Characterization of purified recombinant endo-1,5-arabinanase (AbnA) revealed that it is active at a wide pH range (pH 4.0-7.0) and an optimum temperature at 70 °C. The immobilization of the AbnA was performed via covalent binding onto agarose-modified supports: glyoxyl iminodiacetic acid-Ni 2+, glyoxyl amine, glyoxyl (4% and 10%) and cyanogen bromide activated sepharose. The yield of immobilization was similar on glyoxyl amine and glyoxyl (96%), and higher than glyoxyl iminodiacetic acid-Ni 2+ (43%) support. The thermal inactivation of these immobilized preparations showed that the stability of the AbnA immobilized on glyoxyl 4 and 10% was improved by 4.0 and 10.3-fold factor at 70 °C. The half-life of glyoxyl 4% derivative at 60 °C was ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Older research outputs will score higher simply because theyve had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,964 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries ...
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself), mainly by repressing transcriptional repressors of those genes, and represses transcription of acid-expressed genes. Required for meiosis, sporulation and invasive growth.
We have shown that A. nidulans can distinguish between conditions of nitrogen sufficiency, nitrogen limitation, and nitrogen starvation and adjust accordingly the expression levels of nitrogen catabolic genes. These changes are AreA dependent and reflect alterations in the level and activity of AreA. Furthermore, we have shown that A. nidulans can respond to nitrogen starvation by altering the dynamics of nuclear entry and exit of AreA, using regulated nuclear exit to provide a rapid response when nutritional conditions change.. We favor a model in which, in the presence of nitrogen sources, AreA is present in the nucleus at a relatively low level due to a balance between nuclear entry and exit. When repressing metabolites are at high levels (for example, when ammonium or glutamine is the source of nitrogen), the level of transcriptionally active AreA is low due to accelerated areA mRNA turnover and NmrA inhibition of AreA activation ability (1, 32). When poorer (limiting) nitrogen sources are ...
BACKGROUND: Fungi are important players in the turnover of plant biomass because they produce a broad range of degradative enzymes. Aspergillus nidulans, a well-studied saprophyte and close homologue to industrially important species such as A. niger and A. oryzae, was selected for this study. RESULTS: A. nidulans was grown on sorghum stover under solid-state culture conditions for 1, 2, 3, 5, 7 a ...
Galagan JE et al. Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature 438 (7071), 1105-1115 (2005 ...
The enzyme contains heme. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized with
Pontecorvo, G., Roper, J.A., Chemmons, L.M., Macdonald, K.D. and Bufton, A.W.J. (1953) The genetics of Aspergillus nidulans. Advances in Genetics, 5, pp. 141-238. (doi:10.1016/S0065-2660(08)60408-3) ...
Specimen Code: CUP-LP-000261; Determined By: G.T. Hill; Date Determined: Sep 13,1999; Slant: no; -80° C Freezer: no; Herbarium: CCFB; d H2O: n/a; Collected By: G.T. Hill; Date(s) Collected: 13 Sep 1999; Soil type: BoE; Source: on rotten wood; Locality Code: Sector 22; Locality Name: Lindsay-Parsons Biodiversity Preserve; Township: West Danby, Tompkins Co.; State: NY; Country: USA; Elevation: 900-1400 ft.; Loc Latitude: 42°1836N; Loc Longitude: 76°3036W ...
Bicikl ima geometrijo in opremo, ki se imo svetuje rekreativcu začetniku, ki ima malce resnejši namen pogostega odkrivanja kolovozov in stezic za hišo. Nima pa še izkušenj, časa in/ali konjske kondicije. Oprema je kvalitativno zelo uravnotežena. Razred deore je primeren tudi za hujšo zlorabo in je cenovno ugoden (menjava komponent zaradi obrabe) rekreativcu, ki tedensko naredi do 100km (2000 višincev), nima izrazite tehnike vožnje, ter še išče svoje mesto v različnih oblikah gorskega kolesarjenja (in nima manije vsak gram šteje:). Pogosto se menja gonilni ležaj, račna, verižnika in veriga,... Če opisane menjaš 1x letno te v razredu material deore pride okrog 80€. V razredu deore XT najmanj 160€, v razredu XTR pa te 170€-200€ pride samo zadnji verižnik ...
Dai unocchiata a questi esempi di libri sfogliabili per bambini per trovare ispirazione in vista delle tue pubblicazioni future e dei progetti da te ideati.
Coloured scanning electron micrograph (SEM) of Aspergillus nidulans hyphae and sexual spores. A. nidulans (also known as Emericella nidulans) is a filamentous fungus that is the only member of the genus Aspergillus that forms sexual spores through meiosis (seen here in this image as large spores). A. nidulans is also a homothallic fungus, meaning it can form asexual spores by producing conidiphores that bear chains of asexual spores. A. nidulans. has been an important research organism for studying eukaryotic cell biology and has a long history of use for the study of a wide range of subjects including basic genetic problems (recombination, DNA repair, mutation), cell cycle control and pathogenesis, as well as metabolism of other Aspergillus species. A. nidulans produces the toxin, sterigmatocysin, which may lead to food contamination. Magnification: x440 when shortest axis printed at 25 millimetres. - Stock Image C032/3077
Coloured scanning electron micrograph (SEM) of Aspergillus nidulans hyphae and sexual spores. A. nidulans (also known as Emericella nidulans) is a filamentous fungus that is the only member of the genus Aspergillus that forms sexual spores through meiosis (seen here in this image as large spores). A. nidulans is also a homothallic fungus, meaning it can form asexual spores by producing conidiphores that bear chains of asexual spores. A. nidulans. has been an important research organism for studying eukaryotic cell biology and has a long history of use for the study of a wide range of subjects including basic genetic problems (recombination, DNA repair, mutation), cell cycle control and pathogenesis, as well as metabolism of other Aspergillus species. produces the toxin, sterigmatocysin, which may lead to food contamination. Magnification: x440 when shortest axis printed at 25 millimetres. - Stock Image C032/3079
TY - JOUR. T1 - The Aspergillus nidulans sepA gene encodes an FH1/2 protein involved in cytokinesis and the maintenance of cellular polarity. AU - Harris, Steven D.. AU - Hamer, Lisbeth. AU - Sharpless, Kathryn E.. AU - Hamer, John E.. PY - 1997/6/16. Y1 - 1997/6/16. N2 - Cytokinesis (septation) in the fungus Aspergillus nidulans occurs through the formation of a transient actin ring at the incipient division site. Temperature-sensitive mutations in the sepA gene prevent septation and cause defects in the maintenance of cellular polarity, without affecting growth and nuclear division. The sepA gene encodes a member of the growing family of FH1/2 proteins, which appear to have roles in morphogenesis and cytokinesis in organisms such as yeast and Drosophila. Results from temperature shift and immunofluorescence microscopy experiments strongly suggest that sepA function requires a preceding mitosis and that sepA acts prior to actin ring formation. Deletion mutants of sepA exhibit ...
Yu, J.H. and T.J. Leonard. 1998. Culture conditions control expression of the genes for alfatoxin and sterigmatocystin biosynthesis in Aspergillus parasiticus and Aspergillus nidulans. Appl. Environ. Microbiol. 64: 2275-2277.. Yu, J.H., R. Butchko, M. Fernandes, N. Keller, T.J. Leonard, T.H. Adams. 1996. Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus. Current Genetics 29:549-555.. Brown, D.W., J.H. Yu, H.S. Kelkar, M. Fernandes, T.C. Nesbit, T.C. Keller, N.P. Adams and T.J. Leonard. 1996. Twenty-five co-regulated transcripts define a secondary metabolism gene cluster in Asperfillus nidulans. Proc. Natl. Acad. Sci. USA. 93:1418-1422.. Feng, G.H. and T.J. Leonard. 1995. Characterization of the polyketide synthase gene (pksLi) required for aflatoxin biosynthesis in Aspergillus nidulans. J. Bact. 177: 6246-6254.. Yu, J.H. and T.J. Leonard. 1995. Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I ...
Purine hydroxylase I from Aspergillus nidulans was purified 850-fold. The purified preparations exhibited the spectral and catalytic properties, including broad specificity for oxidizing and reducing substrates, typical of molybdenum/flavin/iron-sulphur-containing hydroxylases (oxotransferases).
We present the case of a 3-year-old boy who was diagnosed with cerebral abscesses due to Aspergillus nidulans infection on day 28 of induction chemotherapy for acute lymphoblastic leukemia. He responded well to treatment with voriconazole and caspofungin, making a full recovery. There are very few cases of invasive aspergillosis reported in children during induction chemotherapy for acute leukemia and A. nidulans is rare in the absence of chronic granulomatous disease.
The catabolism of glucose and xylose was studied in a wild type and creA deleted (carbon catabolite de-repressed) strain of Aspergillus nidulans. Both strains were cultivated in bioreactors with either glucose or xylose as the sole carbon source, or in the presence of both sugars. In the cultivations on single carbon sources, it was demonstrated that xylose acted as a carbon catabolite repressor (xylose cultivations), while the enzymes in the xylose utilisation pathway were also subject to repression in the presence of glucose (glucose cultivations). In the wild type strain growing on the sugar mixture, glucose repression of xylose utilisation was observed; with xylose utilisation occurring only after glucose was depleted. This phenomenon was not seen in the creA deleted strain, where glucose and xylose were catabolised simultaneously. Measurement of key metabolites and the activities of key enzymes in the xylose utilisation pathway revealed that xylose metabolism was occurring in the creA ...
Filamentous fungi play vital roles in human health, agriculture and bioprocessing. In all of these situations fungi are often exposed to nutrient limitation, which can impact their behavior. Autophagy is a eukaryotic cellular process, induced under nutrient deficient conditions, which recycles internal components for cell survival. Autophagy can also be gratuitously induced in rich growth medium, using the drug rapamycin. To address our hypotheses, we have studied fungi and cell wall material properties of the model fungus, Aspergillus nidulans, under autophagic conditions. For example, it has been observed that during fungal fermentation nutrient limitation leads to a greater degree of hyphal fragmentation. We hypothesize that under nutrient deprived conditions autophagy is involved in recycling cell wall components, thereby weakening the wall and resulting in this increased degree of fragmentation. In all experiments, fungi were subjected to two media conditions - with and without rapamycin. ...
Roundup® is a glyphosate-based herbicide (GBH) used worldwide both in agriculture and private gardens. Thus, it constitutes a substantial source of environmental contaminations, especially for water and soil, and may impact a number of non-target organisms essential for ecosystem balance. The soil filamentous fungus Aspergillus nidulans has been shown to be highly affected by a commercial formulation of Roundup® (R450), containing 450 g/L of glyphosate (GLY), at doses far below recommended agricultural application rate. In the present study, we used two-dimensional gel electrophoresis combined to mass spectrometry to analyze proteomic pattern changes in A. nidulans exposed to R450 at a dose corresponding to the no-observed-adverse-effect level (NOAEL) for macroscopic parameters (31.5 mg/L GLY among adjuvants). Comparative analysis revealed a total of 82 differentially expressed proteins between control and R450-treated samples, and 85% of them (70) were unambiguously identified. Their ...
The complete sequencing of genomes of several Aspergillus species, including A. nidulans, revealed that these fungal species have a potential to produce a surprising large range of natural products. The discovery of new natural products and their biosynthetic pathway in A. nidulans has been facilitated by a rapid gene modification technique by which the replacement of targeted genes, can be achieved within a few days instead of months. The natural products emericellamides A, C-F, a family of cyclic polyketide/nonribosomal peptides, biosynthesized by the mixed PKS/NRPS cluster (AN2544-AN2547), have been identified with the application of this rapid method. Once the emericellamide gene cluster was successfully elucidated, it was undertaken to determine the genes responsible for the biosynthetic pathway of two terpenes, austinol and dehydroaustinol, in the same species. Although the preliminary data showed that the four putative terpene cyclase genes that were studied are not responsible for the ...
2005. The Aspergillus nidulans phytochrome FphA represses sexual development in red light. Curr. Biol. 15:1833-1838. Casselton, L. A. 2002. Mate recognition in fungi. Heredity 88:142- 147. , J. P. Debeaupuis, J. Sarfati, J. Lortholary, P. Ribaud, P. Shah, M. Cornet, H. V. Thien, E. Gluckman, G. Bru ¨cker, and J. P. Latge´. 1998. Molecular typing of environmental and patient isolates of Aspergillus fumigatus from various hospital settings. J. Clin. Microbiol. 36:1494-1500. Debeaupuis, J. , J. Sarfati, V. Momany, T. Tanaka, T. Kumagai, K. Asai, M. Machida, W. C. Nierman, D. W. Denning, M. Caddick, M. Hynes, M. Paoletti, R. Fischer, B. Miller, P. Dyer, M. S. Sachs, S. A. Osmani, and B. W. Birren. 2005. Sequencing and comparative analysis of Aspergillus nidulans. Nature 438:1105-1115. , M. Christensen, A. H. Onions, J. I. Pitt, and R. A. Samson. 1985. Infrageneric taxa of Aspergillus, p. 55-62. In R. A. Samson and J. I. ), Advances in Penicillium and Aspergillus Systematics. Plenum Press, New ...
Horizontal gene transfer (HGT) is a fast-track mechanism that allows genetically unrelated organisms to exchange genes for rapid environmental adaptation. We developed a new phyletic distribution-based software, HGT-Finder, which implements a novel bioinformatics algorithm to calculate a horizontal transfer index and a probability value for each query gene. Applying this new tool to the Aspergillus fumigatus, Aspergillus flavus, and Aspergillus nidulans genomes, we found 273, 542, and 715 transferred genes (HTGs), respectively. HTGs have shorter length, higher guanine-cytosine (GC) content, and relaxed selection pressure. Metabolic process and secondary metabolism functions are significantly enriched in HTGs. Gene clustering analysis showed that 61%, 41% and 74% of HTGs in the three genomes form physically linked gene clusters (HTGCs). Overlapping manually curated, secondary metabolite gene clusters (SMGCs) with HTGCs found that 9 of the 33 A. fumigatus SMGCs and 31 of the 65 A. nidulans SMGCs share
Members of the septin gene family are highly homologous and have been found in several species of fungi and animals where they play critical roles in cytokinesis and cell surface organization (reviewed by Field and Kellogg 1999). Interestingly, septins have not been reported in algae or land plants. It seems most likely that septins arose in a common ancestor of fungi and animals after divergence of the green plants (Wainrightet al. 1993). It is also possible that septins arose in an earlier common ancestor shared by green plants, fungi, and animals and were later lost in the green plant lineage by nonorthologous gene displacement or lineage-specific gene loss. Regardless of the evolutionary path, it is not surprising that septins are present in animals and fungi and absent in plants in view of the major differences in division mechanisms. Animal and fungal cells divide centripetally; that is, the division furrow progresses from the cortex to the interior. Plant cells, however, divide ...
Aspergillus comprises a diverse group of species based on morphological, physiological and phylogenetic characters, which significantly impact biotechnology, food production, indoor environments and human health. Aspergillus was traditionally associated with nine teleomorph genera, but phylogenetic data suggest that together with genera such as Polypaecilum, Phialosimplex, Dichotomomyces and Cristaspora, Aspergillus forms a monophyletic clade closely related to Penicillium. Changes in the International Code of Nomenclature for algae, fungi and plants resulted in the move to one name per species, meaning that a decision had to be made whether to keep Aspergillus as one big genus or to split it into several smaller genera. The International Commission of Penicillium and Aspergillus decided to keep Aspergillus instead of using smaller genera. In this paper, we present the arguments for this decision. We introduce new combinations for accepted species presently lacking an Aspergillus name and ...
The Outcomes and Evidence-based Practice Committee (OEBPC) will facilitate the efforts of APSA members either individually or as an organization to develop clinical outcomes data and evidence-based recommendations relevant to the practice of pediatric surgery. At the request of the APSA membership and/or the BOG of APSA, the OEBPC will serve to identify important areas of clinical guidelines and research in order to formulate and disseminate appropriate recommendations to assist APSA members in their practices. The OEBPC will be a central resource for APSA members to help promote clinical and outcomes research in pediatric surgery. The OEBPC will work collaboratively with other existing APSA committees to identify and address educational and/or programmatic needs and opportunities for the APSA membership as they relate to clinical outcomes. At the request of the APSA membership and/or the BOG of APSA, the OCT Committee will serve to identify important areas of clinical guidelines and research in ...
In response to changes in ambient pH the opportunistic pathogen Candida albicans differentially expresses a number of genes. The response to pH affects morphological differentiation and virulence. The pathway controlling the pH response terminates in the zinc-finger containing transcription factor encoded by RIM101/PRR2. By analogy to the pH response pathway of Aspergillus nidulans, PRR1 of C. albicans encodes a protein that is presumably required to convert Rim101p from an inactive to an active form by proteolytic removal of a C-terminal peptide. A prr1Delta mutant is compromised in its ability to differentiate into the filamentous form. Spontaneous phenotypic revertants of a prr1Delta mutant were selected by their ability to form filamentous colonies. These mutants were also found to be defective in pH-dependent gene expression. Each of the eight mutants examined contained a heterozygous dominant mutation at the RIM101 locus. This was demonstrated genetically in all of the mutants, and ...
S cerevisiae SST2 protein: a regulator of G-protein signalling (RGS); promotes recovery after pheromone-induced growth arrest in Saccharomyces cerevisiae; has 30% amino acid sequence identity with Aspergillus nidulans flbA protein
Viral DNA-binding proteins have served as good models to study the biochemistry of transcription regulation and chromatin dynamics. Computational analysis of viral DNA-binding regulatory proteins and identification of their previously undetected homologs encoded by cellular genomes might lead to a better understanding of their function and evolution in both viral and cellular systems. The phyletic range and the conserved DNA-binding domains of the viral regulatory proteins of the poxvirus D6R/N1R and baculoviral Bro protein families have not been previously defined. Using computational analysis, we show that the amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain is suggested to be homologous to the fungal DNA-binding APSES domain. We provide evidence for the KilA-N and APSES domains sharing a common fold with the nucleic acid-binding
1. The strict photoautotrophic blue-green alga, Anacystis nidulans, has a high requirement for manganese; its absence from the culture medium causes significant changes in the morphology and the...
Carbon catabolite repression (CCR) is a mechanism by which micro-organisms preferentially utilize more easily metabolizable carbon sources in comparison to less easily metabolizable carbon sources. It prevents the organisms from unnecessary expenditure of energy and enables them to exploit the nutrients in appropriate manner. It represents a complex system of gene regulation. The main aim of this study was to study the intracellular localization of proteins involved in CCR including CreA, CreB, CreC and CreD in A. nidulans in repressing and derepressing conditions. The major regulatory protein involved in CCR in A. nidulans is CreA. It is a DNA-binding repressor, but very little is known about the molecular events that allow CreA function to result in appropriate regulation in response to carbon source. To determine the amount and localization of CreA in different carbon sources, strains were made over-expressing GFP and HA tagged CreA. Western analysis showed that high levels of full length ...
Digital Morphology account of the razorbill, Alca torda, featuring CT-generated animations of the skull and expert commentary by Dr. N. Adam Smith
i want to know about effectiveness of AMWAY PRODUCT APSA 80 IF somebody have used it i want to know that the how much you think it is effective?
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Sichtbehinderung durch Nebel kann einen geplanten Flug verunmöglichen. Die Kenntnis der Aussagekraft von Flugwetterinformationen ist deshalb fundamental.
We have cloned an actin-encoding cDNA from the dimorphic fungus Histoplasma capsulatum, an important pathogen of humans. The predicted amino acid sequence as well as the general codon pattern of Histoplasma actin revealed the highest degree of similarity to the actin of the filamentous ascomycete Aspergillus nidulans. Southern blot analysis determined that actin was encoded by a single copy in the Histoplasma genome. Northern blot analysis showed a single 1700 nt transcript in yeast and mould cells as well as in cells undergoing the temperature induced mould-to-yeast conversion. Actin mRNA levels normalized to 18 S rRNA were found to be equivalent in all the stages examined, except for a sharp four-fold transient decrease 4 h into the mould-to-yeast conversion. These data suggest that actin mRNA would not be a suitable internal marker for expression studies during Histoplasma mould-to-yeast morphogenesis.
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
A detailed and comprehensive genome annotation can be considered a prerequisite for the analysis and interpretation of omics data. GO provides a framework for functional annotation and has been proven to be a valuable tool for omics data analysis, especially in combination with enrichment statistics. Currently, the GO reference genome project [23] provides the most comprehensive manually curated GO annotation for twelve model organisms and is intended to serve as a reference for automated mapping of GO annotation to organisms other than these major models. From the reference genome projects, Saccharomyces cerevisiae and Schizosaccharomyces pombe are most closely related to the genus Aspergillus.. A. nidulans has so far been the only Aspergillus species with comprehensive genome scale GO annotation based on both orthology mapping to S. cerevisiae and extensive manual curation [9] of gene-specific literature. We have thus mapped the A. nidulans GO annotation to all other Aspergillus species (see ...
Moraes, A. M. L., M. Corrado, V. L. Holanda, G. L. Costa, M. Ziccardi, R. de Lourenço-de-Oliveira & P. C. Oliveira. Aspergillus from Brazilian mosquitoes - I. Genera Aedes and Culex from Rio de Janiero State, Mycotaxon 78: 413-422. 2001.. ABSTRACT: As part of an ongoing survey of potential biological control fungi from insects in Brazil. aspergilli were isolated from 625 mosquitoes belonging to 17 species in the genera Aedes and Culex. Two hundred and fifteen isolates belonging to 17 Aspergillus species were found. Aspergillus niger, Aspergillus flavus and Aspergillus nidulans were the most frequently isolated species. Two other species, Aspoergillus fischerianus and Aspergillus heteromorphus were new records for insects. The macro- and microcharacteristics of the Brazilian isolates are compared to those in previously published descriptions. The habitat and geographical distribution of these fungi in Brazil is reviewed.. KEYWORDS: biological control, taxonomy, entomogenous fungi. NOMENCLATURAL ...
Isopenicillin N synthase (IPNS) catalyses a key step in the penicillin and cephalosporin biosynthetic pathway which involves the oxidative cyclisation of the acyclic peptide δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV) to isopenicillin N. Based on crystallographic evidence from the Aspergillus nidulans IPNS crystal structure complexed with the substrate ACV (Roach et al. (1997) Nature 387, 827-830), we were able to provide mutational evidence for the critical involvement of the conserved R-X-S motif in ACV binding in IPNS. The crystal structure further implicated arginine-87 in the binding of the aminoadipyl portion of ACV. Thus, in this study, the site-directed mutagenesis of the corresponding arginine-89 in Cephalosporium acremonium IPNS (cIPNS) was performed to ascertain its role in cIPNS. Alteration of arginine-89 to five amino acids from different amino acid groups, namely lysine, serine, alanine, aspartate and leucine, was performed and no activity was detected in all the mutants ...
Citation. Rokas, A., Payne, G., Fedorova, N. D., Baker, S. E., Machida, M., Yu, J., Georgianna, D. R., Dean, R. A., Bhatnagar, D., Cleveland, T. E., Wortman, J. R., Maiti, R., Joardar, V., Amedeo, P., Denning, D. W., Nierman, W. C.. What Can Comparative Genomics Tell Us About Species Concepts In the Genus Aspergillus?. Stud Mycol. 2007 Jan 01; 59: 11-7.. PubMed Citation. Abstract. Understanding the nature of species boundaries is a fundamental question in evolutionary biology. The availability of genomes from several species of the genus Aspergillus allows us for the first time to examine the demarcation of fungal species at the whole-genome level. Here, we examine four case studies, two of which involve intraspecific comparisons, whereas the other two deal with interspecific genomic comparisons between closely related species. These four comparisons reveal significant variation in the nature of species boundaries across Aspergillus. For example, comparisons between A. fumigatus and Neosartorya ...
Eisendle, M., Oberegger, H., Zadra, I. and Haas, H. (2003) The Siderophore System Is Essential for Viability of Aspergillus nidulans Functional Analysis of Two Genes Encoding L-Ornithine N5-Monooxygenase (sidA) and a Non-Ribosomal Peptide Synthetase (sidC). Molecular Microbiology, 49, 359-375.
Filamentous fungi are prolific producers of bioactive secondary metabolites. Recent genome sequencing reveals fungi harbor more secondary metabolites than are currently known. Exploration of fungal secondary metabolism is more attractive today with recent advancements in genomics and molecular biology. Efficient gene-targeting technology is a powerful tool used to "mine" the genome for novel secondary metabolites and identify the genes in the biosynthetic pathway. Furthermore, this technology can be applied to engineering pathways to generate "unnatural" natural products. Integration of biosynthetic engineering with chemical synthesis can introduce greater structural diversity into natural products, a promising avenue for discovering therapeutic drugs. The current work describes strategies that utilize the strengths of biosynthetic engineering and chemical synthesis to generate novel fungal natural products. ❧ Genome mining efforts in Aspergillus nidulans revealed the novel azaphilone ...
In an application of the presented high-density microarray, we identify a carbon source-based response conserved in three aspergilli. The design of the study involving three different species, grown on three different defined minimal media, at three different values of pH, increases the likelihood of the found genes to be the true conserved "core" response to growth on xylose and not responses relying on an extra factor in addition to xylose (with the possible exception of abundant oxygen). We also believe this approach validates our argument that the xylanolytic transcriptional activator XlnR is a conserved system, even though it has not previously been studied in A. nidulans. Backed by the finding that the 5′-GGNTAAA-3′ motif is present and in some cases conserved as syntenic regions in all three species, we propose that the motif is indeed a XlnR motif and conserved in A. nidulans, A. niger, and A. oryzae. As a point of interest, a study of the homologous genes and their promoter regions ...
Enzymes participating in ethanol utilization and catabolism. Each row of panels shows the expression levels of a set of enzymes catalyzing a reaction from ethan
TY - JOUR. T1 - Effect of barium and nickel on the growth of Anacystis nidulans. AU - Lee, Lee. AU - Lustigman, B.. PY - 1996/6/1. Y1 - 1996/6/1. UR - http://www.scopus.com/inward/record.url?scp=0029659917&partnerID=8YFLogxK. U2 - 10.1007/s001289900142. DO - 10.1007/s001289900142. M3 - Article. C2 - 8661890. AN - SCOPUS:0029659917. VL - 56. SP - 985. EP - 992. JO - Bulletin of Environmental Contamination and Toxicology. JF - Bulletin of Environmental Contamination and Toxicology. SN - 0007-4861. IS - 6. ER - ...
An endophytic fungus isolated from the inflorescence axis of Aster tataricus is proposed as a new species. Phylogenetic analyses based on sequences from the ribosomal DNA cluster (the ITS1+5.8S+ITS2, 18S, and 28S regions) and the RPB2 gene revealed a relationship between the unknown fungus and the Stictidaceae lineage of the Ostropales. The new species, Cyanodermella asteris, grows in standard fungal growth media as a fluffy, pink filamentous fungus. Asexual and sexual sporulation has not yet been observed on media or in the plant ...
Results] We were able to observe 3,622 genes modulated in at least one timepoint in the mutant when compared to the wild type strain (3,211 and 411 at 10 and 30 minutes, respectively). Decreased mRNA abundance in the ΔcrzA was seen for genes encoding calcium transporters, transcription factors and genes that could be directly or indirectly involved in calcium metabolism. Increased mRNA accumulation was observed for some genes encoding proteins involved in stress response. AfCrzA overexpression in A. fumigatus increases the expression of several of these genes. The deleted strain of one of these genes, AfRcnA, belonging to a class of endogenous calcineurin regulators, calcipressins, had more calcineurin activity after exposure to calcium and was less sensitive to menadione 30 μM, hydrogen peroxide 2.5 mM, EGTA 25 mM, and MnCl2 25 mM. We constructed deletion, overexpression, and GFP fusion protein for the closely related A. nidulans AnRcnA. GFP::RcnA was mostly detected along the germling, did ...
Conclusion Since its discovery in 2004, LaeA has provided the research community with a new paradigm of regulation of SM gene clusters in fungi. The global nature of SM regulation by LaeA, presumably as part of the Velvet Complex, suggests an evolved requirement for production of certain SM in concert with morphological development, possibly as part of a stress response in protecting fungi from both abiotic and biotic stresses (Hong et al. 2013). Although present in most Ascomycetes, LaeA and other members of the Velvet complex are conspicuously missing in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Twenty-three single gene mutants were obtained with LaeA representing one of three mutants showing loss of aflR expression. Chemical characterization of DlaeA showed a decrease not only in sterigmatocystin production but also in multiple secondary metabolites (Bok and Keller 2004). The number and types of LaeA regulated SMs in A. nidulans and other fungi are described in the next section. ...
Biological and chemical profiling of an Australian strain of the fungus Aspergillus unilateralis (MST-F8675), isolated from a soil sample collected near Mount Isa, Queensland, revealed a complex array of metabolites displaying broad chemotherapeutic properties. Noteworthy among these metabolites were a u
Aspergillus oryzae ATCC ® 14895™ Designation: NRRL 1989 [CBS 134.52, NBIR 2016] Application: produces miso produces soy sauce produces taka-diastase koji produces koji for fermented food products
A Phospholipase A1 which is capable of hydrolyzing a phospholipid to produce a 2-acyl lysophospholipid and is obtainable from species of the fungus Aspergillus.
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Zloženie:. Sójové boby (46,31%), voda, morská soľ (13,13%), alkohol, fermentačné činidlo: Aspergillus oryzae Tradičný japonský výrobok, ktorý sa podobne ako shoyu používa k dochucovaniu pokrmov.. Tamari na rozdiel od Shoyu má výraznejšiu chuť a hustejšiu konzistenciu tmavšiu farbu a neobsahuje lepok. ...
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Creation of isopenicillin N from δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV) in the penicillin and cephalosporin biosynthetic pathway is catalysed by isopenicillin N synthase (IPNS), a non-heme iron-containing dioxygenase. A tripeptide R-X-S motif which consists of arginine-281 and serine-283 (Cephalosporium acremonium IPNS numbering) was found to be conserved in IPNS and other related proteins. These two amino acids mentioned were proposed to have a role in ACV substrate binding by the recent Aspergillus nidulans IPNS crystal structure. Using site-directed mutagenesis, arginine-281 in C. acremonium IPNS (cIPNS) was earlier found to be essential for catalysis by our group. Similarly, serine-283 in cIPNS was also altered by site-directed mutagenesis to determine its role in cIPNS. No measurable activity was detected from the resultant mutant using enzyme bioassays. It is most likely that the elimination of the mutants substrate-binding capability similar to that of arginine-281 lead to the ...
We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri NRRL181 and Aspergillus clavatus NRRL1. Comparative genomic analysis of A1163 with the recently sequenced A. fumigatus isolate Af293 has identified core, variable and up to 2% unique genes in each genome. While the core genes are 99.8% identical at the nucleotide level, identity for variable genes can be as low 40%. The most divergent loci appear to contain heterokaryon incompatibility (het) genes associated with fungal programmed cell death such as developmental regulator rosA. Cross-species comparison has revealed that 8.5%, 13.5% and 12.6%, respectively, of A. fumigatus, N. fischeri and A. clavatus genes are species-specific. These genes are significantly smaller in size than core genes, contain fewer exons and exhibit a subtelomeric bias. Most of them cluster together in 13 chromosomal islands, ...
Preferred for the invention is CBMs of Carbohydrate-Binding Module Family 20. CBMs of Carbohydrate-Binding Module Family 20 suitable for the invention may be derived from glucoamylases of Aspergillus awamori (SWISSPROT Q12537), Aspergillus kawachii (SWISSPROT P23176), Aspergillus niger (SWISSPROT P04064), Aspergillus oryzae (SWISSPROT P36914), from alpha-amylases of Aspergillus kawachii (EMBL#AB008370), Aspergillus nidulans (NCBI AAF17100.1), from beta-amylases of Bacillus cereus (SWISSPROT P36924), or from CGTases of Bacillus circulans (SWISSPROT P43379). Preferred is a CBM from the alpha-amyiase of Aspergillus kawachii (EMBL:#AB008370) as well as CBMs having at least 50%, 60%, 70%, 80% or even at least 90% homology to the CBM of the alpha-amyiase of Aspergillus kawachii (EMBL#AB008370), i.e. a CBM having at least 50%, 60%, 70%, 80% or even at least 90% homology to the amino acid sequence of SEQ ID NO:6. Also preferred for the invention are the CBMs of Carbohydrate-Binding Module Family 20 ...
Entry into anaphase and proteolysis of B-type cyclins depend on a complex containing the tetratricopeptide repeat proteins Cdc16p, Cdc23p, and Cdc27p. This particle, called the anaphase-promoting complex (APC) or cyclosome, functions as a cell cycle-regulated ubiquitin-protein ligase. Two additional subunits of the budding yeast APC were identified: The largest subunit, encoded by the APC1 gene, is conserved between fungi and vertebrates and shows similarity to BIMEp from Aspergillus nidulans. A small heat-inducible subunit is encoded by the CDC26 gene. The yeast APC is a 36S particle that contains at least seven different proteins. ...
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Cryptococcus neoformans is a basidiomycetous fungal pathogen that claims 625,000 lives annually worldwide. Particularly among the immunocompromised, it is the leading cause of fungal meningitis following pulmonary colonization and dissemination to the central nervous system via the blood-brain barrier. The success of C. neoformans as a pathogen is largely attributable to metabolic scavenging during starvation conditions within the hosts environment. Lung alveolar macrophages, which are among the first immune effectors to combat an initial pulmonary infection, present a glucose- and amino acid-poor environment that likely necessitates metabolism of nonpreferred carbon sources such as lactate and acetate for establishment of a pulmonary infection. While acetate transporters have been characterized in ascomycetous fungi such as ,em,Saccharomyces cerevisiae, Candida albicans, Aspergillus nidulans,/em, and Yarrowia lipolytica the role of acetate production and transport in C. neoformans is not ...
Involvement of a Velvet Protein FgVeA in the Regulation of Asexual Development, Lipid and Secondary Metabolisms and Virulence in Fusarium graminearum. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Aspergillus amyR protein: a transcriptional activator gene, involved in the amylolytic gene expression in Aspergillus oryzae; GenBank AB012945
A principal característica que diferencia a aveia nuda da aveia com casca é a separação da casca durante o processo de trilha. A expressão incompleta do caráter nuda é um dos entraves à utilização comercial da aveia nuda. Os objetivos deste estudo foram: (i) analisar a expressão do caráter nuda nas panículas dos genitores e da população segregante nas gerações F2 e F3, (ii) estimar o número de genes desse caráter, (iii) analisar possíveis diferenças na expressão do caráter quando utilizadas sementes com e sem casca na semeadura, (iv) determinar a associação do caráter nuda aos caracteres estatura e florescimento. O trabalho foi conduzido na Estação Experimental Agronômica da UFRGS, nos anos 2005 e 2006. Foram utilizados como genitores as linhagens UFRGS 995080-1 (nuda) e UFRGS 970486-3 (com casca), que foram avaliados conjuntamente com a população segregante quanto a presença e distribuição dos grãos sem casca na panícula. O caráter nuda em aveia é governado ...
This bracket-like fungus is roughly semi-circular in shape with an uneven upper surface. Upper surface orange to yellow-orange in colour, lower surface cinnamon coloured; pores angular 3-4 per mm. Attached to dead wood often associated with a tree trunk.. ...
Aspergillus fumigatus Basics Laboratory Metabolites Adverse health reactions Specific settings Diagnostic Bibliography Basics A. fumigatus has been associated with each and every type of health problems linked to environmental moulds: irritation and inflammation, allergy, asthma, pneumonitis, toxic effects as well as a wide range of infections. Infections have been reported
List of fungus species in the genus Aspergillus. The Aspergillus genus includes several hundred fungus species, including: Contents A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Aspergillus acidusAspergillus aculeatinusAspergillus aculeatus Aspergillus aeneusAspergillus affinisAspergillus alabamensisAspergillus alliaceus Aspergillus amazonicusAspergillus ambiguusAspergillus amoenusAspergillus amstelodamiAspergillus amyloliquefaciensAspergillus amylovorusAspergillus anomalusAspergillus anthodesmisAspergillus apicalisAspergillus appendiculatusAspergillus arachidicolaAspergillus arenariusAspergillus arviiAspergillus asperescensAspergillus assulatusAspergillus astellatusAspergillus aurantiobrunneusAspergillus aureofulgensAspergillus aureolatusAspergillus aureoterreusAspergillus aureusAspergillus auricomusAspergillus australensisAspergillus austroafricanusAspergillus avenaceusAspergillus awamori Top A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Aspergillus baarnensisAspergillus ...
Isopenicillin N synthase (IPNS) is a non-heme iron-dependent enzyme belonging to the oxidoreductase family. This enzyme catalyzes the formation of isopenicillin N from δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (LLD-ACV). N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 ⇌ {\displaystyle \rightleftharpoons } isopenicillin N + 2 H2O This reaction is a key step in the biosynthesis of penicillin and cephalosporin antibiotics. The active sites of most isopenicillin N synthases contain an iron ion. This enzyme is also called isopenicillin N synthetase. A Fe(II) metal ion in the active site of the enzyme is coordinated by at least two histidine residues, an aspartate residue, a glutamine residue, and two water molecules in the absence of a bound substrate. Just two histidine residues and one aspartic acid residue are entirely conserved. Therefore, it is highly significant that these two histidine residues, His214 and His270, and one aspartic acid residue, Asp216, are precisely the ones ...
The filamentous fungus Aspergillus niger was transformed with the hepatitis B virus S gene encoding the major viral envelope protein under control of the constitutive A. nidulans glyceraldehyde-3-phosphate dehydrogenase (gpdA) promoter. Approximately seven copies of the expression cassette were integrated on the genome, resulting in high-level transcription of the S gene. Production of the 24-kDa S protein and a 48-kDa S protein dimer in the membrane-associated protein fraction of the recombinant A. niger strain was shown through Western analysis. Electron microscopy of partially purified recombinant S protein revealed the formation of spherical pseudoviral particles with a diameter of 22 nm. The production level of hepatitis B pseudoviral particles was estimated to be 0.4 mg/1 culture, which compares favourably with the reported levels initially obtained in yeast, indicating the potential of the Aspergillus expression system as an alternative, cost-effective vaccine production system.. ...
Orizin (EC 3.4.21.63, Aspergillus alkaline proteinaza, aspergilopeptidaza B, API 21, aspergilopepsin B, aspergilopepsin F, Aspergillus candidus alkalna proteinaza, Aspergillus flavus alkalna proteinaza, Aspergillus melleus semialkalna proteinaza, Aspergillus oryzae alkalna proteinaza, Aspergillus parasiticus alkalna proteinaza, Aspergillus serin proteinaza, Aspergillus sydowi alkalna proteinaza, Aspergillus soya alkalna proteinaza, Aspergillus melleus alkalna proteinaza, Aspergillus sulphureus alkalna proteinaza, prozim, P 5380, kiorinaza, seaproza S, semi-alkalna proteaza, sumizim MP, prozim 10, onoproza, onoproza SA, proteaza P, promelaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju. ...
High-level expression of the Streptomyces clavuligerus isopenicillin N synthase gene in Escherechia coli. Isolation and antifungal and antioomycete activities of aerugine produced by Pseudomonas fluorescens strain MM-B16
TY - JOUR. T1 - Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. AU - Szigeti, Gyöngyi. AU - Sedaghati, Ebrahim. AU - Mahmoudabadi, Ali Zarei. AU - Naseri, Ali. AU - Kocsubé, S.. AU - Vágvölgyi, C.. AU - Varga, J.. PY - 2012/7. Y1 - 2012/7. N2 - Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited ...
Aspergillus glaucus. Aspergillus lentulus. Aspergillus nidulans. Aspergillus niger. Aspergillus ochraceus. Aspergillus oryzae. ... Aspergillus restrictus. Aspergillus sojae. Aspergillus sydowii. Aspergillus tamari. Aspergillus terreus. Aspergillus ustus. ... Aspergillus alliaceus. Aspergillus caesiellus. Aspergillus caespitosus. Aspergillus candidus. Aspergillus carneus. Aspergillus ... Aspergillus deflectus. Aspergillus egyptiacus. Aspergillus fischerianus. Aspergillus flavus. Aspergillus foetidus. Aspergillus ...
Regulatory circuits of the amdS gene of Aspergillus nidulans. Antonie van Leeuwenhoek. 1994, 65 (3): 179-82. PMID 7847883. doi: ... Identification and toxigenic potential of the industrially important fungi, Aspergillus oryzae and Aspergillus sojae. Journal ... Abe K, Gomi K, Hasegawa F, Machida M. Impact of Aspergillus oryzae genomics on industrial production of metabolites. ... Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants. Current ...
Aspergillus nidulans Strain:FGSC A4, model organism (2005[20]). *Aspergillus niger Strain:ATCC 1015 (DOE Joint Genome institute ... Aspergillus oryzae Strain:RIB40, industrial use (2005[22]). *Aspergillus terreus NIH 2624, statin producer and pathogen (2005, ... "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 (7071): 1105-15. ... "Home - Aspergillus carbonarius ITEM 5010 v3". genome.jgi-psf.org. Retrieved 24 November 2018.. ...
December 2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 ( ... Aspergillus oryzae, known in English as koji (Japanese: 麹, Hepburn: kōji), is a filamentous fungus (a mold) used in Chinese and ... Fujita, Chieko, Tokyo Foundation Koji, an Aspergillus *^ Shurtleff, W.; Aoyagi, A. History of Koji - Grains and/or Soybeans ... Aspergillus oryzae genome from the Database of Genomes Analysed at NITE (DOGAN) ...
Aspergillus nidulans and Emericella nidulans, for asexual and sexual isolates, respectively, of the same species. ... In Asia, Aspergillus oryzae is added to a pulp of soaked soya beans to make soy sauce, and is used to break down starch in rice ... Most famously, Neurospora crassa, several species of yeasts, and Aspergillus species are used in many genetics and cell biology ... Aspergillus flavus, which grows on peanuts and other hosts, generates aflatoxin, which damages the liver and is highly ...
Restricting colony expansion in Aspergillus nidulans in microbiology. *Decellularization of animal-derived tissues ...
"ATP-Citrate Lyase Is Required for Production of Cytosolic Acetyl Coenzyme A and Development in Aspergillus nidulans". ...
Thus Aspergillus niger is considered a form taxon. In contrast, isolates of its close relative, Aspergillus nidulans, revealed ... Hence the formerly classified Aspergillus species is now properly called Emericella nidulans. ... For example, the ubiquitous and industrially important mold, Aspergillus niger, has no known sexual cycle. ... which was already named Emericella nidulans. When such a teleomorphic stage is known, that name will take priority over the ...
... including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth & ...
"Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans". Current Biology. 17 (16): 1384-9 ... Selfing in the homothallic fungus Aspergillus nidulans involves activation of the same mating pathways characteristic of sex in ... Among the 250 known species of aspergilli, about 33% have an identified sexual state.[26] Among those Aspergillus species that ... Dyer PS, O'Gorman CM (2012). "Sexual development and cryptic sexuality in fungi: insights from Aspergillus species". FEMS ...
... latus Thom & Raper 1939. Emericella nidulans (Eidam) Vuill. 1927. Diplostephanus nidulans (Eidam) Langeron ... Sterigmatocystis nidulans nicollei Pinoy 1906. Sterigmatocystis nidulans Eidam 1883. Aspergillus nidulans nicollei (Pinoy) ... Aspergillus nidulellus Samson & W. Gams 1986. Emericella nidulans lata (Thom & Raper) Subram. 1972. Emericella nidulans ... An Aspergillus nidulans in nahilalakip ha genus nga Aspergillus, ngan familia nga Trichocomaceae.[2][3] ...
QSMs have been studied in Candida albicans, C. dubliniensis, Aspergillus niger, A. nidulans, and Fusarium graminearum. QSMs can ...
A Cytosine Methyltransferase Homologue Is Essential for Sexual Development in Aspergillus nidulans. PLoS ONE 3(6): e2531. doi: ... Related functions have been found in other fungi, including Neurospora and Aspergillus species. Malagnac, F; Wendel, B; Goyon, ...
Historically, A. unguis was assigned to the A. nidulans group, a common group of soil-borne fungi due to the resemblance of its ... Aspergillus unguis is a member of the genus Aspergillus in the phylum Ascomycota, and the asexual state (anamorph) of ... Raper1 Fennell2, K.B.1, D.I.2 (1965). The Genus Aspergillus. Williams and Wilkins. p. 686. "Aspergillus unguis". www.mycobank. ... Aspergillus laokiashanensis and Aspergillus mellinus. Colonies typically reach up to 2 cm in diameter at 10 days incubation, ...
Chromosome-specific recombinant DNA libraries from the fungus Aspergillus nidulans. Nucleic Acids Res. 1991 Jun 11;19(11):3105- ... it was possible to quickly map the genome of Aspergillus nidulans. This was one of the first genomes physically mapped In ... In vitro reconstruction of the Aspergillus (= Emericella) nidulans genome. Proc. Natl. Acad. Sci. USA 94 (1997), pp. 14564- ...
... is a fermentation product of Aspergillus nidulans and the closely related species, A. rugulosus; discovered in ... Echinocandin B, a novel polypeptide-antibiotic from Aspergillus nidulans var. echinulatus: isolation and structural components ... 1974 in A. nidulans var. echinulatus strain A 32204 in Germany, it was the first of the echinocandin class of antifungals. ...
Aspergillus nidulans produces sterigmatocystin - a precursor to aflatoxins. Aspergillus was found to have horizontally ... Aspergillus to Podospora represents a large metabolic gene transfer which could have contributed to fungal metabolic diversity ... Podospora and Aspergillus show high conservation and microsynteny sterigmatocystin/aflatoxin clusters along with intergenic ... Sterigmatocystin gene transfer has been observed with Podospora anserina and Aspergillus. Horizontal gene transfer in ...
... (also called Emericella nidulans when referring to its sexual form, or teleomorph) is one of many species ... 2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 (7071): 1105- ... doi:10.1111/j.1420-9101.2005.00934.x. "Aspergillus nidulans Project Information". Broad Institute. Retrieved 2011-01-28. ... Echinocandin B, a novel polypeptide-antibiotic from Aspergillus nidulans var. echinulatus: isolation and structural components ...
Aspergillus nidulans, Cryptococcus neoformans, and Candida albicans. As a genetic repository, the FGSC has always endeavored to ... To that end the FGSC web-site hosts extensive protocols for Neurospora and Aspergillus. Other materials and services are ... Other strain collections include Allomyces (pdf), Aspergillus niger, and Neurospora strains from the historical Tatum lab ... The FGSC distributes strains of Neurospora and Aspergillus, as well as limited numbers of Fusarium, Magnaporthe and most ...
... including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): ...
... aspergillus flavus MeSH B05.381.081.295 --- aspergillus fumigatus MeSH B05.381.081.420 --- aspergillus nidulans MeSH B05.381. ... 081.450 --- aspergillus niger MeSH B05.381.081.480 --- aspergillus ochraceus MeSH B05.381.081.500 --- aspergillus oryzae MeSH ...
Deletion of the rid homolog in Aspergillus nidulans, dmtA, results in loss of fertility while deletion of the rid homolog in ... "A cytosine methyltransferase homologue is essential for sexual development in Aspergillus nidulans". PLoS ONE. 3 (6): e2531. ...
... cerevisiae human mouse and Caenorhabditis elegans Trichoderma reesei and Aspergillus nidulans Drosophila melanogaster Candida ...
Aspergillus nidulans, mold subject of genetics studies Coprinus cinereus, mushroom (genetic studies of mushroom development, ...
"Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans". Curr. Biol. 17 (16): 1384-9. doi ... Selfing in the homothallic fungus Aspergillus nidulans involves activation of the same mating pathways characteristic of sex in ... Among the 250 known species of aspergilli, about 36% have an identified sexual state Among those Aspergillus species that ... Dyer PS, O'Gorman CM (January 2012). "Sexual development and cryptic sexuality in fungi: insights from Aspergillus species". ...
... including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): ... a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans". Cell Growth Differ. 5 (6): 625-35 ...
3 glucanase from non-induced cultures of Aspergillus nidulans". Biochim. Biophys. Acta. 258: 541-547. doi:10.1016/0005-2744(72) ...
A. nidulans was the first Aspergillus species to have its entire genome sequenced, and considering that A. nidulans is sexually ... A. nidulans was the first Aspergillus species to have its entire genome sequenced, and considering that A. nidulans is sexually ... A. nidulans was the first Aspergillus species to have its entire genome sequenced, and considering that A. nidulans is sexually ... www.researchgate.net/figure/Aspergillus-nidulans-var-nidulans-a-e-Teleomorph-and-f-h-Anamorph-a-Ascomata_fig2_259390442 [ ...
A. nidulans was the first Aspergillus species to have its entire genome sequenced, and considering that A. nidulans is sexually ... www.researchgate.net/figure/Aspergillus-nidulans-var-nidulans-a-e-Teleomorph-and-f-h-Anamorph-a-Ascomata_fig2_259390442 [ ... A. nidulans is credited with opening many doors for research of the entire genus of Aspergillus as well as for medical research ... The use of A. nidulans as a model species allows for the understanding of other Aspergillus species (e.g., A. niger, A. oryzea ...
Ten patients (31 %) did not have an elevated Aspergillus IgG, and only 4 patients had elevated Aspergillus precipitins. Twelve ... This study aims to review the radiology, presentation, and histological features of lung nodules caused by Aspergillus spp. ... Nine of the 32 patients (31 %) isolated an A. fumigatus from their sputum sample, one of whom also had A. nidulans isolated ... Aspergillus IgG antibody results were available for 32 patients. In ten patients (31 %) the Aspergillus IgG was within normal ...
Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. ... Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. ... Recently, we discovered that intimate physical interaction of the important model fungus Aspergillus nidulans with the soil- ... Recently, we discovered that intimate physical interaction of the important model fungus Aspergillus nidulans with the soil- ...
... nidulans glyceraldehyde-3-phosphate dehydrogenase (gpdA) promoter. Approximately seven copies of the expression cassette were ... Evaluation of Aspergillus as a host for the production of viral proteins using hepatitis B as a model  Pluddemann, Annette, ... Evaluation of Aspergillus niger as host for virus-like particle production, using the hepatitis B surface antigen as a model. ... Cellulase production from spent lignocellulose hydrolysates by recombinant aspergillus niger  Alriksson B.; Rose S.H.; Van Zyl ...
1953) The genetics of Aspergillus nidulans. Adv Genet.; 5: 141-238. * Sambrook J, Fritsch EF, Maniatis T. (1989) Molecular ... Vainstein LM, Peberdy J. (1991) Regulation of invertase in Aspergillus nidulans: the effect of different carbon sources. J Gen ... Overexpression of the yeast DPM1 gene encoding dolichylphosphate mannose synthase (DPMS) in an Aspergillus nidulans mutant ( ... 1993) Co-transformation with autonomously replicating helper plasmids facilitates gene cloning from an Aspergillus nidulans ...
Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J ... Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis ... Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular ...
filamentous fungi (Aspergillus nidulans). *Firmicute bacteria (Streptococcus pneumoniae). *fission yeast (Schizosaccharomyces ...
2008-10 A Single Amino Acid Substitution in One of the Lipases of Aspergillus nidulans Confers Resistance to the Antimycotic ...
Yuri Amatnieks Aspergillus Collection*A. glaucus. *A. flavus. *A. fumigatus. *A. nidulans ... Please note: The Aspergillus Website does not accept advertisments. , all content is published on merit. BB.com. Site Sponsors ... Aspergillus Website Newsletters. Our most recent newsletters (since August 2018) can be found here. ...
Yuri Amatnieks Aspergillus Collection*A. glaucus. *A. flavus. *A. fumigatus. *A. nidulans ... Please note: The Aspergillus Website does not accept advertisments. , all content is published on merit. BB.com. Site Sponsors ... Aspergillus Otomycosis references. References. Andral G, Gavarret J. Ann Chim Phys. 1843; 88. ... Harima N, Inoue T, Kubota T, Okada O, Ansai S, Manabe M, Ichinoe M, Kasai T. A case of otomycosis caused by Aspergillus ...
Transcriptome changes initiated by carbon starvation in Aspergillus nidulans Melinda Szilágyi, Márton Miskei, Zsolt Karányi, ... bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans Wen- ... was found in a suppressor screen of an Aspergillus nidulans secondary metabolism (SM) mutant in which overexpression of rsmA ... Here we characterized and contrasted SM in mutants of RsmA and four other A. nidulans bZIP proteins (NapA, ZipA, ZipB and ZipC ...
filamentous fungi (Aspergillus nidulans). *Firmicute bacteria (Streptococcus pneumoniae). *fission yeast (Schizosaccharomyces ...
Aspergillus nidulans CutA (AnCutA), synthesizes C/U-rich 3′-terminal extensions in vivo Here, using high-throughput sequencing ...
Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stress. Mol ... Osmotic stress-coupled maintenance of polar growth in Aspergillus nidulans. Mol Microbiol 2002;43:1065-1078 [CrossRef][PubMed] ... Ruijter GJ, Bax M, Patel H, Flitter SJ, van de Vondervoort PJ et al. Mannitol is required for stress tolerance in Aspergillus ... Combinatorial impact of osmotic and heat shocks on the composition of membrane lipids and osmolytes in Aspergillus niger * ...
Glucose does not activate the plasma-membrane-bound-H+-ATPase but affects pmaA transcript abundance in Aspergillus nidulans. ...
A homolog of the Aspergillus nidulans spore-specific catalase gene, catA (53), was identified in E. festucae (EfM2.069120). The ... Aspergillus nidulans transcription factor AtfA interacts with the MAPK SakA to regulate general stress responses, development ... catA, a new Aspergillus nidulans gene encoding a developmentally regulated catalase. Curr. Genet. 29:352-359. ... SakA MAP kinase is involved in stress signal transduction, sexual development and spore viability in Aspergillus nidulans. Mol ...
The Aspergillus nidulans F-box protein GrrA links SCF activity to meiosis. Mol. Microbiol.61:76-88. ... The Aspergillus nidulans xprG (phoG) gene encodes a putative transcriptional activator involved in the response to nutrient ... The Aspergillus nidulans xprF gene encodes a hexokinase-like protein involved in the regulation of extracellular proteases. ... Aspergillus fumigatus secreted proteases, p. 87-106. In J.-P. Latgé and W. J. Steinbach (ed.), Aspergillus fumigatus and ...
Aspergillus nidulans asexual development: making the most of cellular modules. Trends Microbiol 18:569-576. doi:10.1016/j.tim. ... Identification and characterization of Aspergillus nidulans mutants impaired in asexual development under phosphate stress. ... Aspergillus nidulans (Ani), Penicillium digitatum (Pdi), and S. pombe (Spo). The main domains and nuclear localization signal ( ... domain and the NLS motif are also present in the orthologs of all examined filamentous fungi except Aspergillus nidulans and ...
In filamentous fungi such as A. nidulans and N. crassa, four families of myosins have been found, including myosin-I, myosin-II ... Enke, C.,, N. Zekert,, D. Veith,, C. Schaaf,, S. Konzack, and, R. Fischer. 2007. Aspergillus nidulans Dis1/XMAP215 protein AlpA ... Harris, S. D.,, L. Hamer,, K. E. Sharpless, and, J. E. Hamer. 1997. The Aspergillus nidulans sepA gene encodes an FH1/2 protein ... Takeshita, N.,, S. Yamashita,, A. Ohta, and, H. Horiuchi. 2006. Aspergillus nidulans class V and VI chitin synthases CsmA and ...
The organism identified as Aspergillus unguis comes under the Aspergillus nidulans group where most of the GT-BGL producers ... The fungus showed 99% similarity to Aspergillus unguis strain which comes under the Aspergillus nidulans group where most of ... glucosidase of GH3 family from Aspergillus nidulans and Aspergillus acculateus. GH5 degenerate primers also gave amplification ... Sequencing results of the 1.0 Kb amplicon matched Aspergillus nidulans β -glucosidase gene which belongs to the GH1 family. The ...
NitA of Aspergillus (Emericella) nidulans. *1.A.16.2.3. Probable formate uptake permease (Wood et al., 2003). ...
... are revealed by repression of chsB expression in Aspergillus nidulans. Most bathroom injuries in children occurred while they ...
Aspergillus cultures were inoculated with 106 spores/ml and grown. Posted on September 29, 2019. by fgfr0865 ... These genes were aligned to the ppo genes from A. nidulans and to the LDS from G. graminis and a phylogenetic tree was created ... Table 2 Aspergillus strains used in this study Strain Genotype A. niger N402 (FGSCA733) cspA1 A. niger UU-A049.1 nicA1, leuA1, ... Aspergillus cultures were inoculated with 106 spores/ml and grown at 30°C on a rotary shaker (Inova 2300; New Brunswick ...
Conidial germination in Aspergillus nidulans requires RAS signaling and protein synthesis. Genetics 155: 647-656. ... Fungal spore germination: insights from nuclear genetics of A. nidulans and N. crassa . Fungal Genet. Biol., 21: 163-172. ... Nutrient requirements in germination of conidiospores of Aspergillus niger . Mycopathologia 92: 111-113. ...
  • Deletion analysis of 36 of 40 acetyltransferases, including histone acetyltransferases (HATs) of A. nidulans, demonstrated that the Saga/Ada complex containing the HAT GcnE and the AdaB protein is required for induction of the orsellinic acid gene cluster by the bacterium. (bath.ac.uk)
  • Furthermore, the production of secondary metabolites in A. nidulans is accompanied by a global increase in H3K14 acetylation. (bath.ac.uk)
  • Asexual Sporulation in Aspergillus nidulans. (kenyon.edu)
  • A. nidulans is one fo the Aspergilli that is known to cause infections in the lungs of various types of birds. (kenyon.edu)
  • The metabolic network of A. nidulans has been found to include 676 unique biochemical reactions as well as 113 different transport processes. (kenyon.edu)
  • A. nidulans has been used to study a wide array of processes and topics such as cell cycles, mutations, infections, and evolutionary processes. (kenyon.edu)
  • In addition, A. nidulans is known to cause infections that lead to the mycosis of the guttural pouch in horses. (kenyon.edu)
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