A species of imperfect fungi from which the antibiotic nidulin is obtained. Its teleomorph is Emericella nidulans.
A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.
A species of imperfect fungi from which the antibiotic fumigatin is obtained. Its spores may cause respiratory infection in birds and mammals.
An imperfect fungus causing smut or black mold of several fruits, vegetables, etc.
A species of imperfect fungi which grows on peanuts and other plants and produces the carcinogenic substance aflatoxin. It is also used in the production of the antibiotic flavicin.
Proteins found in any species of fungus.
Reproductive bodies produced by fungi.
A carcinogenic mycotoxin produced in high yields by strains of the common molds, Aspergillus versicolor, A. nidulans, and an unidentified species of Bipolaris. It causes necrosis of the liver and kidney and has an inhibitory effect on orotic acid incorporation into nuclear RNA.
The functional hereditary units of FUNGI.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.
Infections with fungi of the genus ASPERGILLUS.
Microscopic threadlike filaments in FUNGI that are filled with a layer of protoplasm. Collectively, the hyphae make up the MYCELIUM.
A systemic agricultural fungicide used for control of certain fungal diseases of stone fruit.
Deoxyribonucleic acid that makes up the genetic material of fungi.
Reproduction without fusion of two types of cells, mostly found in ALGAE; FUNGI; and PLANTS. Asexual reproduction occurs in several ways, such as budding, fission, or splitting from "parent" cells. Only few groups of ANIMALS reproduce asexually or unisexually (PARTHENOGENESIS).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A mitosporic fungal species used in the production of penicillin.
Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.
Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A mitosporic Trichocomaceae fungal genus that develops fruiting organs resembling a broom. When identified, teleomorphs include EUPENICILLIUM and TALAROMYCES. Several species (but especially PENICILLIUM CHRYSOGENUM) are sources of the antibiotic penicillin.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
A disaccharide consisting of two glucose units in an alpha (1-6) glycosidic linkage.
An imperfect fungus present on most agricultural seeds and often responsible for the spoilage of seeds in bulk storage. It is also used in the production of fermented food or drink, especially in Japan.
An imperfect fungus that produces ochratoxins and contaminates EDIBLE GRAIN and coffee beans.
An acid which is found in cinchona bark and elsewhere in plants. (From Stedman, 26th ed)
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
An enzyme that converts UDP glucosamine into chitin and UDP. EC 2.4.1.16.
A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.
The chromosomal constitution of cells, in which each type of CHROMOSOME is represented twice. Symbol: 2N or 2X.
An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, pyrophosphate, and acetyl CoA. It acts also on propionates and acrylates. EC 6.2.1.1.
Toxic compounds produced by FUNGI.
Ribonucleic acid in fungi having regulatory and catalytic roles as well as involvement in protein synthesis.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
The complete gene complement contained in a set of chromosomes in a fungus.
The body of a fungus which is made up of HYPHAE.
Oxidoreductases that are specific for the reduction of NITRATES.
Mutation process that restores the wild-type PHENOTYPE in an organism possessing a mutationally altered GENOTYPE. The second "suppressor" mutation may be on a different gene, on the same gene but located at a distance from the site of the primary mutation, or in extrachromosomal genes (EXTRACHROMOSOMAL INHERITANCE).
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
The chromosomal constitution of cells, in which each type of CHROMOSOME is represented once. Symbol: N.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Infections of the respiratory tract with fungi of the genus ASPERGILLUS. Infections may result in allergic reaction (ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS), colonization in pulmonary cavities as fungus balls (MYCETOMA), or lead to invasion of the lung parenchyma (INVASIVE PULMONARY ASPERGILLOSIS).
Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.
The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
The interference in synthesis of an enzyme due to the elevated level of an effector substance, usually a metabolite, whose presence would cause depression of the gene responsible for enzyme synthesis.
A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.
Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.
Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)

Expression of atrC - encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans - is sensitive to cycloheximide. (1/1128)

A new member of the ABC superfamily of transmembrane proteins in Aspergillus nidulans has been cloned and characterized. The topology of conserved motifs subgroups AtrC in the P-glycoprotein cluster of ABC permeases, the members of this subfamily, are known to participate in multidrug resistance (MDR) in diverse organisms. Alignment results display significant amino acid similarity to AfuMDR1 and AflMDR1 from Aspergillus fumigatus and flavus, respectively. Northern analysis reveals that atrC mRNA levels are 10-fold increased in response to cycloheximide. Evidence for the existence of eight additional hitherto unpublished ABC transporter proteins in A. nidulans is provided.  (+info)

Insertion analysis of putative functional elements in the promoter region of the Aspergillus oryzae Taka-amylase A gene (amyB) using a heterologous Aspergillus nidulans amdS-lacZ fusion gene system. (2/1128)

Expression of the Taka-amylase A gene (amyB) of Aspergillus oryzae is induced by starch or maltose. The A. oryzae amyB gene promoter contains three highly conserved sequences, designated Regions I, II, and III, compared with promoter regions of the A. oryzae glaA encoding glucoamylase and the agdA encoding alpha-glucosidase. To identify the function of these sequences within the amyB promoter, various fragments containing conserved sequences in the amyB promoter were introduced into the upstream region of the heterologous A. nidulans amdS gene (encoding acetamidase) fused to the Escherichia coli lacZ gene as a reporter. Introduction of the sequence between -290 to -233 (the number indicates the distance in base pairs from the translation initiation point (+1)) containing Region III significantly increased the expression of the lacZ reporter gene in the presence of maltose. The sequence between -377 to -290 containing Region I also increased the lacZ activity, but its maltose inducibility was less than that of Region III. The sequence between -233 to -181 containing Region II had no effect on the expression. These results indicated that Region III is most likely involved in the maltose induction of the amyB gene expression.  (+info)

The GATA factor AreA is essential for chromatin remodelling in a eukaryotic bidirectional promoter. (3/1128)

The linked niiA and niaD genes of Aspergillus nidulans are transcribed divergently. The expression of these genes is subject to a dual control system. They are induced by nitrate and repressed by ammonium. AreA mediates derepression in the absence of ammonium and NirA supposedly mediates nitrate induction. Out of 10 GATA sites, a central cluster (sites 5-8) is responsible for approximately 80% of the transcriptional activity of the promoter on both genes. We show occupancy in vivo of site 5 by the AreA protein, even under conditions of repression. Sites 5-8 are situated in a pre-set nucleosome-free region. Under conditions of expression, a drastic nucleosomal rearrangement takes place and the positioning of at least five nucleosomes flanking the central region is lost. Remodelling is strictly dependent on the presence of an active areA gene product, and independent from the NirA-specific and essential transcription factor. Thus, nucleosome remodelling is independent from the transcriptional activation of the niiA-niaD promoter. The results presented cast doubts on the role of NirA as the unique transducer of the nitrate induction signal. We demonstrate, for the first time in vivo, that a GATA factor is involved directly in chromatin remodelling.  (+info)

Unique DNA binding specificity of the binuclear zinc AlcR activator of the ethanol utilization pathway in Aspergillus nidulans. (4/1128)

AlcR is the transcriptional activator in Aspergillus nidulans, necessary for the induction of the alc gene cluster. It belongs to the Zn2Cys6 zinc cluster protein family, but contains some striking differences compared with other proteins of this group. In this report, we show that no dimerization element is present in the entire AlcR protein which occurs in solution as a monomer and binds also to its cognate sites as a monomer. Another important feature of AlcR is its unique specificity for single sites occurring naturally as inverted or direct repeats and sharing a common motif, 5'-(T/A)GCGG-3'. Like most other Zn2Cys6 proteins, AlcR contacts directly with the CGG triplet and, in addition, the upstream adjacent guanine is required for high affinity binding. We also establish that the flanking regions outside the core play an essential role in tight binding. From our in vitro analysis, we propose an optimal AlcR-binding site which is 5'-PuNGCGG-AT rich 3'.  (+info)

nimO, an Aspergillus gene related to budding yeast Dbf4, is required for DNA synthesis and mitotic checkpoint control. (5/1128)

The nimO predicted protein of Aspergillus nidulans is related structurally and functionally to Dbf4p, the regulatory subunit of Cdc7p kinase in budding yeast. nimOp and Dbf4p are most similar in their C-termini, which contain a PEST motif and a novel, short-looped Cys2-His2 zinc finger-like motif. DNA labelling and reciprocal shift assays using ts-lethal nimO18 mutants showed that nimO is required for initiation of DNA synthesis and for efficient progression through S phase. nimO18 mutants abrogated a cell cycle checkpoint linking S and M phases by segregating their unreplicated chromatin. This checkpoint defect did not interfere with other checkpoints monitoring spindle assembly and DNA damage (dimer lesions), but did prevent activation of a DNA replication checkpoint. The division of unreplicated chromatin was accelerated in cells lacking a component of the anaphase-promoting complex (bimEAPC1), consistent with the involvement of nimO and APC/C in separate checkpoint pathways. A nimO deletion conferred DNA synthesis and checkpoint defects similar to nimO18. Inducible nimO alleles lacking as many as 244 C-terminal amino acids supported hyphal growth, but not asexual development, when overexpressed in a ts-lethal nimO18 strain. However, the truncated alleles could not rescue a nimO deletion, indicating that the C terminus is essential and suggesting some type of interaction among nimO polypeptides.  (+info)

The abfB gene encoding the major alpha-L-arabinofuranosidase of Aspergillus nidulans: nucleotide sequence, regulation and construction of a disrupted strain. (6/1128)

Using a DNA fragment containing the Aspergillus niger abfB gene as a probe, the homologous Aspergillus nidulans gene, designated abfB, has been cloned from a genomic library containing size-selected HindIII fragments. The nucleotide sequence of the A. nidulans abfB gene shows strong homology with the A. niger abfB, Trichoderma reesei abf-1 and Trichoderma koningii alpha-L-arabinofuranosidase/beta-xylosidase genes. Regulation of abfB expression has been investigated in cultures induced with L-arabitol. The accumulation of abfB mRNA, total alpha-L-arabinofuranosidase activity and AbfB protein levels have been determined in a wild-type A. nidulans strain as well as in different mutant strains. These strains are affected either in their response to ambient pH (paIA1 and pacC(c)14 mutants), carbon catabolite repression (creA(d)4 mutant), the ability to utilize L-arabitol as a carbon source (araA1 mutant) or a combination of both latter genotypes (araA1 creA(d)4). The results obtained indicate that the expression of the A. nidulans abfB gene was higher at acidic pHs and was superinduced in this double mutant. Furthermore, disruption of the abfB gene demonstrated that in A. nidulans AbfB is the major p-nitrophenyl alpha-L-arabinofuranoside-hydrolysing activity but at least one minor activity is expressed, which is involved in the release of L-arabinose from polysaccharides.  (+info)

Zinc-regulated biosynthesis of immunodominant antigens from Aspergillus spp. (7/1128)

ASPND1 and ASPF2 are immunodominant antigens from Aspergillus nidulans and A. fumigatus, respectively, that are readily synthesized in infections in the human host, as demonstrated by their reactivity with more than 80% of sera from patients with aspergilloma or allergic bronchopulmonary aspergillosis. We demonstrate here that both antigens are exclusively produced under situations of low bioavailability of free Zn2+. Addition of micromolar concentrations of Zn2+ to the culture medium strongly stimulated Aspergillus growth but totally inhibited ASPND1 or ASPF2 production. This effect was specific, since other divalent metals had no effect. Removal of endogenous Zn2+ by a chelator also stimulated ASPND1 production, and the effect was specifically reversed by Zn2+. These results suggest a possible role of these antigens in the survival of the fungus in the lungs.  (+info)

Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction. (8/1128)

Aspergillus nidulans utilizes phenylacetate as a carbon source via homogentisate, which is degraded to fumarate and acetoacetate. Mutational evidence strongly suggested that phenylacetate is converted to homogentisate through two sequential hydroxylating reactions in positions 2 and 5 of the aromatic ring. Using cDNA substraction techniques, we have characterized a gene, denoted phacA, whose transcription is strongly induced by phenylacetate and which putatively encodes a cytochrome P450 protein. A disrupted phacA strain does not grow on phenylacetate but grows on 2-hydroxy- or 2, 5-dihydroxyphenylacetate. Microsomal extracts of the disrupted strain are deficient in the NADPH-dependent conversion of phenylacetate to 2-hydroxyphenylacetate. We conclude that PhacA catalyzes the ortho-hydroxylation of phenylacetate, the first step of A. nidulans phenylacetate catabolism. The involvement of a P450 enzyme in the ortho-hydroxylation of a monoaromatic compound has no precedent. In addition, PhacA shows substantial sequence divergence with known cytochromes P450 and defines a new family of these enzymes, suggesting that saprophytic fungi may represent a source of novel cytochromes P450. Phenylacetate is a precursor for benzylpenicillin production. phacA disruption increases penicillin production 3-5-fold, indicating that catabolism competes with antibiotic biosynthesis for phenylacetate and strongly suggesting strategies for Penicillium chrysogenum strain improvement by reverse genetics.  (+info)

O-glycosylation has been considered a limiting factor in protein secretion in filamentous fungi. Overexpression of the yeast DPM1 gene encoding dolichylphosphate mannose synthase (DPMS) in an Aspergillus nidulans mutant (BWB26A) deficient in O-glycosylation caused an increase in the number of secretory vesicles and changes in protein secretion. However, the secretory proteins, primarily O-mannosylated glucoamylase and N-glycosylated invertase, were mainly trapped in the periplasmic space. Different glycoforms of invertase were found insite the cells, in the periplasmic space and in the cultivation medium. Our data point to the importance of the cell wall as a barrier in protein secretion ...
TY - JOUR. T1 - Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. AU - Nuetzmann, Hans-Wilhelm. AU - Reyes-Dominguez, Yazmid. AU - Scherlach, Kirstin. AU - Schroeckh, Volker. AU - Horn, Fabian. AU - Gacek, Agnieszka. AU - Schümann, Julia. AU - Hertweck, Christian. AU - Strauss, Joseph. AU - Brakhage, Axel A. PY - 2011/8/23. Y1 - 2011/8/23. N2 - Sequence analyses of fungal genomes have revealed that the potential of fungi to produce secondary metabolites is greatly underestimated. In fact, most gene clusters coding for the biosynthesis of antibiotics, toxins, or pigments are silent under standard laboratory conditions. Hence, it is one of the major challenges in microbiology to uncover the mechanisms required for pathway activation. Recently, we discovered that intimate physical interaction of the important model fungus Aspergillus nidulans with the soil-dwelling bacterium Streptomyces rapamycinicus specifically ...
The biosynthesis of the beta-lactam antibiotic penicillin in the filamentous fungus Aspergillus nidulans is catalyzed by three enzymes that are encoded by the acvA, ipnA, and aatA genes. A variety of cis-acting DNA elements and regulatory factors form a complex regulatory network controlling these beta-lactam biosynthesis genes. Regulators involved include the CCAAT-binding complex AnCF and AnBH1. AnBH1 acts as a repressor of the penicillin biosynthesis gene aatA. Until now, however, little information has been available on the signal transduction cascades leading to the transcription factors. Here we show that inhibition of protein kinase C (Pkc) activity in A. nidulans led to cytoplasmic localization of an AnBH1-enhanced green fluorescent protein (EGFP) fusion protein. Computer analysis of the genome and screening of an A. nidulans gene library revealed that the fungus possesses two putative Pkc-encoding genes, which we designated pkcA and pkcB. Only PkcA showed all the characteristic features ...
Hyphal tip growth in fungi is important because of the economic and medical importance of fungi, and because it may be a useful model for polarized growth in other organisms. We have investigated the central questions of the roles of cytoskeletal elements and of the precise sites of exocytosis and endocytosis at the growing hyphal tip by using the model fungus Aspergillus nidulans. Time-lapse imaging of fluorescent fusion proteins reveals a remarkably dynamic, but highly structured, tip growth apparatus. Live imaging of SYNA, a synaptobrevin homologue, and SECC, an exocyst component, reveals that vesicles accumulate in the Spitzenkörper (apical body) and fuse with the plasma membrane at the extreme apex of the hypha. SYNA is recycled from the plasma membrane by endocytosis at a collar of endocytic patches, 1-2 μm behind the apex of the hypha, that moves forward as the tip grows. Exocytosis and endocytosis are thus spatially coupled. Inhibitor studies, in combination with observations of ...
1 Adams, T. H., Wieser, J. K., & Yu, J.-H. (1998). Asexual Sporulation in Aspergillus nidulans. Microbiology and Molecular Biology Reviews, 62(2), 545-545. doi: 10.1128/mmbr.62.2.545-545.1998 https://mmbr.asm.org/content/62/1/35.full 2 David, H., Özçelik, I. Ş., Hofmann, G., & Nielsen, J. (2008). Analysis of Aspergillus nidulans metabolism at the genome-scale. BMC Genomics, 9(1), 163. doi: 10.1186/1471-2164-9-163 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386489/ 3 Galagan JE; et al. (2005). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature. 438 (7071): 1105-15. doi:10.1038/nature04341. PMID 16372000. https://www.ncbi.nlm.nih.gov/pubmed/16372000 4 Gugnani, H. C. (2003). Ecology and taxonomy of pathogenic aspergilli. Frontiers in Bioscience, 8(6). doi: 10.2741/1002 ...
1 Adams, T. H., Wieser, J. K., & Yu, J.-H. (1998). Asexual Sporulation in Aspergillus nidulans. Microbiology and Molecular Biology Reviews, 62(2), 545-545. doi: 10.1128/mmbr.62.2.545-545.1998 https://mmbr.asm.org/content/62/1/35.full 2 David, H., Özçelik, I. Ş., Hofmann, G., & Nielsen, J. (2008). Analysis of Aspergillus nidulans metabolism at the genome-scale. BMC Genomics, 9(1), 163. doi: 10.1186/1471-2164-9-163 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386489/ 3 Galagan JE; et al. (2005). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature. 438 (7071): 1105-15. doi:10.1038/nature04341. PMID 16372000. https://www.ncbi.nlm.nih.gov/pubmed/16372000 4 Gugnani, H. C. (2003). Ecology and taxonomy of pathogenic aspergilli. Frontiers in Bioscience, 8(6). doi: 10.2741/1002 ...
In this study, several aspects of nitrate assimilation and transport have been studied using the filamentous fungus Aspergillus nidulans, which has been shown to be safe laboratory organism as judged by its pathogenicity towards insect larvae. In silico analysis of the A. nidulans genome sequence, identified two putative genes designated cnxL and cnxK that might be involved in molybdenum cofactor (a component of nitrate reductase) biosynthesis as well as two putative nitrate reductases encoding genes niaB and niaC. All four genes are hitherto unknown. Although many features of these proteins provided clues of functionality, biochemical and genetical approaches employed in this present study failed to elicit expression of any of these four genes. A NrtA protein structure model was developed based on residue homology with the E. coli GlpT a protein, the structure of which has been solved. The results of thiol cross-linking of three double cysteine mutants in four NrtA essential residues, R87, ...
In Aspergillus nidulans, the transcriptional activator AlcR mediates specific induction of a number of alc genes. The AlcR DNA-binding domain is a zinc binuclear cluster that differs from the other members of the Zn2Cys6 family in several respects. Of these, the most remarkable is its ability to bind in vitro as a monomer to single sites, whereas only repeated sites (direct or inverted) are necessary and functional in vivo. Deletion of the first five amino acids (following the N-terminal methionine) upstream of the AlcR zinc cluster or mutation of a single residue, Arg-6, impairs the AlcR in vitro binding mainly to symmetrical sites. In vivo, the same mutations result in the inability of A. nidulans to grow on ethanol. The alc− phenotype results from a drastic decrease in activation of its own transcription and, in addition, that of the two structural genes, alcA and aldA, required for ethanol oxidation. This defect seems to be correlated to the inability of the Arg-6 AlcR mutant protein to ...
The histone H2A gene of the filamentous fungus Aspergillus nidulans has been cloned and sequenced. There is a single H2A gene in the genome of A. nidulans, and it contains three introns. The introns are 51 nucleotides (nt), 56 nt and 50 nt in length and split codons for amino acids (aa) 18, 48 and 1 …
TY - JOUR. T1 - The Aspergillus nidulans snt genes are required for the regulation of septum formation and cell cycle checkpoints. AU - Kraus, Peter R.. AU - Harris, Steven D.. PY - 2001/11/17. Y1 - 2001/11/17. N2 - In Aspergillus nidulans, germinating conidia undergo multiple rounds of nuclear division before forming a septum. Previous genetic results suggest that the ability to separate nuclear division and septum formation depends upon a threshold level of activity of the cyclin-dependent kinase NIMX,cdk1. Mutations in nimX and nimT, the gene encoding the NIMXcdk1-activating phosphatase, have revealed that Tyr-15 phosphorylation is important for determining the timing of the formation of the first septum. Here, we describe a screen for suppressors of nimT23 (snt), designed to identify additional components of the pathway regulating septum formation. We show that a subset of the snt mutants are defective in the temporal regulation of septum formation and in cell cycle checkpoint responses. ...
The filamentous fungus Aspergillus nidulans senses red using the red light receptor, phytochrome (FphA). In this study, we identified the MAP kinase SakA (also known as HogA) was involved in phytochrome-dependent light sensing by an efficient screening approach. FphA physically interacted with the histidine-containing phosphotransferase (HPt), YpdA in the cytoplasm. Light activation of the SakA pathway depended on FphA. Hence, light plugs into the SakA pathway through phytochrome ...
TY - JOUR. T1 - Analysis of ambient pH stress response mediated by iron and copper intake in Schizosaccharomyces pombe. AU - Higuchi, Yujiro. AU - Mori, Hikari. AU - Kubota, Takeo. AU - Takegawa, Kaoru. PY - 2018/1/1. Y1 - 2018/1/1. N2 - The molecular mechanism of tolerance to alkaline pH is well studied in model fungi Aspergillus nidulans and Saccharomyces cerevisiae. However, how fission yeast Schizosaccharomyces pombe survives under alkaline stress remains largely unknown, as the genes involved in the alkaline stress response pathways of A. nidulans and S. cerevisiae were not found in the genome of this organism. Since uptake of iron and copper into cells is important for alkaline tolerance in S. cerevisiae, here we examined whether iron and copper uptake processes were involved in conferring tolerance to alkaline stress in S. pombe. We first revealed that S. pombe wild-type strain could not grow at a pH higher than 6.7. We further found that the growths of mutants harboring disruption in the ...
Aspergilli represent an extremely important genus of microorganisms which can be both harmful pathogens, and beneficial pharmaceutical producers. In Aspergillis interactions with man, suboptimal nutrient conditions are often present, and lead to a phenomenon known as autophagy. Autophagy is a cellular recycling mechanism that (in the case of macroautophagy) is augmented under nutrient limited conditions to recycle cytoplasmic macromolecules and organelles for use in essential cell functions. Strategic manipulation of autophagy could ultimately lead to improved bioprocesses or anti-fungal treatments. Using the model filamentous fungus Aspergillus nidulans, a number of important questions about autophagy have been addressed.. Critical to the study of autophagy is the balance between self-degradation and self-preservation. Therefore, we adapted an XTT metabolic activity assay for use in filamentous fungi. The assay was first tested using a number of bioprocess related stresses (e.g. temperature, ...
Conidiation in the filamentous ascomycete Aspergillus nidulans requires activation of brlA, a well-characterized transcriptional regulator of genes that are induced specifically during asexual develop
Entry into mitosis in Aspergillus nidulans is regulated by the coordinate function of two serine/threonine protein kinases, NIMXCDC2 and NIMA. NIMXCDC2 is an essential histone H1 kinase that is structurally and functionally homologous to fission yeast p34cdc2 (Osmani et al., 1994). NIMA is a β-casein kinase and is structurally distinct from p34cdc2, containing an amino-terminal catalytic domain and a carboxyl-terminal regulatory domain (Osmani et al., 1988b; Lu et al., 1993; Pu and Osmani, 1995; Pu et al., 1995). Failure to properly activate either of these kinases in G2 prevents the initiation of mitosis, and the combined action of both kinases is critical for coordinating changes in chromosome, microtubule, and nuclear membrane structure during mitosis. For example, mutations preventing the activation of NIMXCDC2 in G2 normally arrests cells in late G2 (Osmani et al., 1991a; 1994). Although overexpression of NIMA can overcome this interphase arrest, the ensuing mitosis is disorganized such ...
Summary: A mutation in a gene designated gmdA has been found to lead to loss of ability of Aspergillus nidulans to use benzamide, phenylacetamide and several other amides as sole nitrogen sources for growth. The gmdAI lesion results in low levels of an enzyme, called the general amidase, which has activity for a wide range of amide substrates. This enzyme is repressed by certain nitrogen-containing metabolites, including ammonium, but is probably not regulated by induction or by carbon catabolite repression. Evidence is presented for the general amidase being distinct from the previously characterized acetamidase and formamidase enzymes. The data also indicate that there is a fourth amidase capable of the hydrolysis of valeramide and hexanamide.
TamA interacts with LeuB, the homologue of Saccharomyces cerevisiae Leu3p, to regulate gdhA expression in Aspergillus nidulans Journal Articles Refereed ...
Molecular cloning and expression in Saccharomyces cerevisiae of two Aspergillus nidulans xylanase genes.: Two Aspergillus nidulans genes, xlnA and xlnB, encodin
a haploid strain of the aspergillus nidulans carried the auxotrophic met-eight mutation conferring a requirement for, Hire Biology Expert, Ask Academics Expert, Assignment Help, Homework Help, Textbooks Solutions
PLEASE HELP We are the parents of a nineteen month old Baby Boy with a life threatening disease. To our knowledge this is the first case of a fungal infection of this type known anywhere in the world. If you can provide any suggestions for helpign our little boy we would be most grateful. Infection: Aspergillus Nidulans in the Central Nervous System. The fungus surrounds the base of the brain and is present in other locations on the covering of the meninges. This was diagnosed following a biopsy taken from his lumbar region. Biopsy was taken September 13, 1996. Cause of Infection: Unknown Patients Present Condition: Beginning to show signs of Hydrocephalus. Vomiting is becoming more frequent and fevers and pain are becoming more frequent and severe. He is developing a little trouble walking. Course of Treatment: Began treatment in September on Amphotericin B and 5FC given by IV. Treatment was determined to be unsuccessful. After one month MRI showed disease had progressed. The next treatment ...
Aspergillus nidulans ATCC ® 24766™ Designation: FGSC A158 (ribo1 bi1) Application: Biomedical Research and Development Material
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It has recently been proposed that acetaldehyde is the physiological inducer of the alc gene system and hence indirectly the activator of the AlcA promoter in Aspergillus nidulans. Here we show that t...
Microbial steroid biotransformation have found wide-reaching application for the production of more precious and functionalized compounds due to their high regio-and stereoselectivity. In this study, the possibility of using filamentous fungi Aspergillus brasiliensis cells in the biotransformation of progesterone (I), a C-21 steroid hormone was studied for the first time.The fungal strain was inoculated into the transformation medium which supplemented with progesterone as a substrate. Biotransformation of this steroid for 7 days afforded 3 different hydroxylated metabolites: 11α-hydroxyprogesterone (II); 14α-hydroxyprogesterone (III) and 21-hydroxyprogesterone (IV).The metabolites were separated by thin layer chromatography. Structure determinations of the metabolites were performed by comparing NMR, MS and IR spectra of starting compound with those of metabolites.These results may be of industrial importance because the metabolites can be used as precursor of some steroid drugs.
In this paper, we characterized the Dis1/XMAP215 family protein AlpA from A. nidulans and found that it is associated with the MT plus end during mitosis and in interphase. AlpA plays a role in controlling MT dynamics and is important for the determination of growth polarity. Whereas the mechanism of MT stabilization was recently shown in S. cerevisiae (1), a role in polarized growth has not been described before. Polarized growth of filamentous fungi depends on the continuous delivery of secretory vesicles (7, 20). These vesicles provide new membranes and deliver, e.g., enzymes for cell wall biosynthesis. Because the vesicles are generated some distance away from the growing tip, they need to be transported long distances. It is assumed that MTs and conventional kinesin provide the basis for this long-distance transportation (18, 23). The first destination of the vesicles is an organelle close to the apex named the vesicle supply center or Spitzenkörper (8). The location of this organelle ...
Dear David, Ive formulated the concept of a gene module, a set of genes used by more than one step of differentiation, in: Gordon, R. (1995). The Hierarchical Genome and Differentiation Waves: Novel Unification of Development, Genetics, and Evolution (Singapore: World Scientific), in prep. Might this match your clusters? To what extent are you dealing with housekeeping genes? To what extent are they related via gene duplication? Best regards, -Dick Gordon, U.Manitoba[May19,95] On 18 May 1995, David H. Griffin wrote: , Is anyone looking at the evolution of genome organization, specifically , clustering of genes with related functions. This has been reported , frequently among fungi, but these clusters are not always universal, , for example the proline genes of Aspergillus nidulans are clustered but , those of Saccharomyces cerevisiae are not. Is gene clustering of , physiologically related genes common amongst other organisms than , fungi? Any examples with references, or at least ...
THE filamentous fungi form mycelial colonies that consist of networks of branched hyphae that grow by apical extension. In the higher fungi (i.e., Ascomycota and Basidiomycota), hyphae are compartmentalized by the formation of cross-walls, or septa. It has long been suspected that the presence of septa allows filamentous fungi to partition cellular environments within a hypha to support colony homeostasis and reproductive development (Gull 1978). The process of septum formation is similar to cytokinesis of animal cells, in that it coordinated with mitosis and requires formation of a contractile actin ring (CAR) (Balasubramanian et al. 2004). By analogy to the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, the CAR likely provides a landmark that guides deposition of the septal wall material. However, unlike these yeasts, the septum is not subsequently degraded and cells remain attached. Furthermore, in most filamentous fungi, a small pore is retained to enable communication ...
per liter NaNO3 6.0 gm KC1 0.52 gm MgSO4. 7H20 0.52 gm KH2PO4 1.52 gm Adjust pH to ca 6.5 (usually requires 1 ml of 1 N NaOH) (Note: If large quantities of minimal are to be used a 2OX stock solution of the above salts can be prepared.) glucose (dextrose) 10.0 gms 2 ml of Hutners trace elements For agar add 15.0 gms Difco Agar ...
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An endo-1,5-arabinanase (abnA) encoding gene from Aspergillus niveus was identified, cloned and successfully expressed in Aspergillus nidulans strain A773. Based on amino acid sequence comparison, the 34-kDa enzyme could be assigned to CAZy GH family 43. Characterization of purified recombinant endo-1,5-arabinanase (AbnA) revealed that it is active at a wide pH range (pH 4.0-7.0) and an optimum temperature at 70 °C. The immobilization of the AbnA was performed via covalent binding onto agarose-modified supports: glyoxyl iminodiacetic acid-Ni 2+, glyoxyl amine, glyoxyl (4% and 10%) and cyanogen bromide activated sepharose. The yield of immobilization was similar on glyoxyl amine and glyoxyl (96%), and higher than glyoxyl iminodiacetic acid-Ni 2+ (43%) support. The thermal inactivation of these immobilized preparations showed that the stability of the AbnA immobilized on glyoxyl 4 and 10% was improved by 4.0 and 10.3-fold factor at 70 °C. The half-life of glyoxyl 4% derivative at 60 °C was ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Older research outputs will score higher simply because theyve had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,964 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries ...
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself), mainly by repressing transcriptional repressors of those genes, and represses transcription of acid-expressed genes. Required for meiosis, sporulation and invasive growth.
We have shown that A. nidulans can distinguish between conditions of nitrogen sufficiency, nitrogen limitation, and nitrogen starvation and adjust accordingly the expression levels of nitrogen catabolic genes. These changes are AreA dependent and reflect alterations in the level and activity of AreA. Furthermore, we have shown that A. nidulans can respond to nitrogen starvation by altering the dynamics of nuclear entry and exit of AreA, using regulated nuclear exit to provide a rapid response when nutritional conditions change.. We favor a model in which, in the presence of nitrogen sources, AreA is present in the nucleus at a relatively low level due to a balance between nuclear entry and exit. When repressing metabolites are at high levels (for example, when ammonium or glutamine is the source of nitrogen), the level of transcriptionally active AreA is low due to accelerated areA mRNA turnover and NmrA inhibition of AreA activation ability (1, 32). When poorer (limiting) nitrogen sources are ...
veA+ is used to indicate the wild-type allele. Please refer to Han, et al (2010) Simple identification of veA1 mutation in Aspergillus nidulans. J Microbiol. 2010 Dec;48(6):885-7.. ...
BACKGROUND: Fungi are important players in the turnover of plant biomass because they produce a broad range of degradative enzymes. Aspergillus nidulans, a well-studied saprophyte and close homologue to industrially important species such as A. niger and A. oryzae, was selected for this study. RESULTS: A. nidulans was grown on sorghum stover under solid-state culture conditions for 1, 2, 3, 5, 7 a ...
Galagan JE et al. Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature 438 (7071), 1105-1115 (2005 ...
PrnB, the L-proline transporter of Aspergillus nidulans, belongs to the Amino acid Polyamine Organocation (APC) transporter family conserved in prokaryotes and eukaryotes. In silico analysis and limited biochemical evidence ...
The enzyme contains heme. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized with
Pontecorvo, G., Roper, J.A., Chemmons, L.M., Macdonald, K.D. and Bufton, A.W.J. (1953) The genetics of Aspergillus nidulans. Advances in Genetics, 5, pp. 141-238. (doi:10.1016/S0065-2660(08)60408-3) ...
Specimen Code: CUP-LP-000261; Determined By: G.T. Hill; Date Determined: Sep 13,1999; Slant: no; -80° C Freezer: no; Herbarium: CCFB; d H2O: n/a; Collected By: G.T. Hill; Date(s) Collected: 13 Sep 1999; Soil type: BoE; Source: on rotten wood; Locality Code: Sector 22; Locality Name: Lindsay-Parsons Biodiversity Preserve; Township: West Danby, Tompkins Co.; State: NY; Country: USA; Elevation: 900-1400 ft.; Loc Latitude: 42°1836N; Loc Longitude: 76°3036W ...
Coloured scanning electron micrograph (SEM) of Aspergillus nidulans hyphae and sexual spores. A. nidulans (also known as Emericella nidulans) is a filamentous fungus that is the only member of the genus Aspergillus that forms sexual spores through meiosis (seen here in this image as large spores). A. nidulans is also a homothallic fungus, meaning it can form asexual spores by producing conidiphores that bear chains of asexual spores. A. nidulans. has been an important research organism for studying eukaryotic cell biology and has a long history of use for the study of a wide range of subjects including basic genetic problems (recombination, DNA repair, mutation), cell cycle control and pathogenesis, as well as metabolism of other Aspergillus species. A. nidulans produces the toxin, sterigmatocysin, which may lead to food contamination. Magnification: x440 when shortest axis printed at 25 millimetres. - Stock Image C032/3077
Coloured scanning electron micrograph (SEM) of Aspergillus nidulans hyphae and sexual spores. A. nidulans (also known as Emericella nidulans) is a filamentous fungus that is the only member of the genus Aspergillus that forms sexual spores through meiosis (seen here in this image as large spores). A. nidulans is also a homothallic fungus, meaning it can form asexual spores by producing conidiphores that bear chains of asexual spores. A. nidulans. has been an important research organism for studying eukaryotic cell biology and has a long history of use for the study of a wide range of subjects including basic genetic problems (recombination, DNA repair, mutation), cell cycle control and pathogenesis, as well as metabolism of other Aspergillus species. produces the toxin, sterigmatocysin, which may lead to food contamination. Magnification: x440 when shortest axis printed at 25 millimetres. - Stock Image C032/3079
TY - JOUR. T1 - The Aspergillus nidulans sepA gene encodes an FH1/2 protein involved in cytokinesis and the maintenance of cellular polarity. AU - Harris, Steven D.. AU - Hamer, Lisbeth. AU - Sharpless, Kathryn E.. AU - Hamer, John E.. PY - 1997/6/16. Y1 - 1997/6/16. N2 - Cytokinesis (septation) in the fungus Aspergillus nidulans occurs through the formation of a transient actin ring at the incipient division site. Temperature-sensitive mutations in the sepA gene prevent septation and cause defects in the maintenance of cellular polarity, without affecting growth and nuclear division. The sepA gene encodes a member of the growing family of FH1/2 proteins, which appear to have roles in morphogenesis and cytokinesis in organisms such as yeast and Drosophila. Results from temperature shift and immunofluorescence microscopy experiments strongly suggest that sepA function requires a preceding mitosis and that sepA acts prior to actin ring formation. Deletion mutants of sepA exhibit ...
Yu, J.H. and T.J. Leonard. 1998. Culture conditions control expression of the genes for alfatoxin and sterigmatocystin biosynthesis in Aspergillus parasiticus and Aspergillus nidulans. Appl. Environ. Microbiol. 64: 2275-2277.. Yu, J.H., R. Butchko, M. Fernandes, N. Keller, T.J. Leonard, T.H. Adams. 1996. Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus. Current Genetics 29:549-555.. Brown, D.W., J.H. Yu, H.S. Kelkar, M. Fernandes, T.C. Nesbit, T.C. Keller, N.P. Adams and T.J. Leonard. 1996. Twenty-five co-regulated transcripts define a secondary metabolism gene cluster in Asperfillus nidulans. Proc. Natl. Acad. Sci. USA. 93:1418-1422.. Feng, G.H. and T.J. Leonard. 1995. Characterization of the polyketide synthase gene (pksLi) required for aflatoxin biosynthesis in Aspergillus nidulans. J. Bact. 177: 6246-6254.. Yu, J.H. and T.J. Leonard. 1995. Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I ...
Purine hydroxylase I from Aspergillus nidulans was purified 850-fold. The purified preparations exhibited the spectral and catalytic properties, including broad specificity for oxidizing and reducing substrates, typical of molybdenum/flavin/iron-sulphur-containing hydroxylases (oxotransferases).
We present the case of a 3-year-old boy who was diagnosed with cerebral abscesses due to Aspergillus nidulans infection on day 28 of induction chemotherapy for acute lymphoblastic leukemia. He responded well to treatment with voriconazole and caspofungin, making a full recovery. There are very few cases of invasive aspergillosis reported in children during induction chemotherapy for acute leukemia and A. nidulans is rare in the absence of chronic granulomatous disease.
The catabolism of glucose and xylose was studied in a wild type and creA deleted (carbon catabolite de-repressed) strain of Aspergillus nidulans. Both strains were cultivated in bioreactors with either glucose or xylose as the sole carbon source, or in the presence of both sugars. In the cultivations on single carbon sources, it was demonstrated that xylose acted as a carbon catabolite repressor (xylose cultivations), while the enzymes in the xylose utilisation pathway were also subject to repression in the presence of glucose (glucose cultivations). In the wild type strain growing on the sugar mixture, glucose repression of xylose utilisation was observed; with xylose utilisation occurring only after glucose was depleted. This phenomenon was not seen in the creA deleted strain, where glucose and xylose were catabolised simultaneously. Measurement of key metabolites and the activities of key enzymes in the xylose utilisation pathway revealed that xylose metabolism was occurring in the creA ...
Filamentous fungi play vital roles in human health, agriculture and bioprocessing. In all of these situations fungi are often exposed to nutrient limitation, which can impact their behavior. Autophagy is a eukaryotic cellular process, induced under nutrient deficient conditions, which recycles internal components for cell survival. Autophagy can also be gratuitously induced in rich growth medium, using the drug rapamycin. To address our hypotheses, we have studied fungi and cell wall material properties of the model fungus, Aspergillus nidulans, under autophagic conditions. For example, it has been observed that during fungal fermentation nutrient limitation leads to a greater degree of hyphal fragmentation. We hypothesize that under nutrient deprived conditions autophagy is involved in recycling cell wall components, thereby weakening the wall and resulting in this increased degree of fragmentation. In all experiments, fungi were subjected to two media conditions - with and without rapamycin. ...
Roundup® is a glyphosate-based herbicide (GBH) used worldwide both in agriculture and private gardens. Thus, it constitutes a substantial source of environmental contaminations, especially for water and soil, and may impact a number of non-target organisms essential for ecosystem balance. The soil filamentous fungus Aspergillus nidulans has been shown to be highly affected by a commercial formulation of Roundup® (R450), containing 450 g/L of glyphosate (GLY), at doses far below recommended agricultural application rate. In the present study, we used two-dimensional gel electrophoresis combined to mass spectrometry to analyze proteomic pattern changes in A. nidulans exposed to R450 at a dose corresponding to the no-observed-adverse-effect level (NOAEL) for macroscopic parameters (31.5 mg/L GLY among adjuvants). Comparative analysis revealed a total of 82 differentially expressed proteins between control and R450-treated samples, and 85% of them (70) were unambiguously identified. Their ...
The complete sequencing of genomes of several Aspergillus species, including A. nidulans, revealed that these fungal species have a potential to produce a surprising large range of natural products. The discovery of new natural products and their biosynthetic pathway in A. nidulans has been facilitated by a rapid gene modification technique by which the replacement of targeted genes, can be achieved within a few days instead of months. The natural products emericellamides A, C-F, a family of cyclic polyketide/nonribosomal peptides, biosynthesized by the mixed PKS/NRPS cluster (AN2544-AN2547), have been identified with the application of this rapid method. Once the emericellamide gene cluster was successfully elucidated, it was undertaken to determine the genes responsible for the biosynthetic pathway of two terpenes, austinol and dehydroaustinol, in the same species. Although the preliminary data showed that the four putative terpene cyclase genes that were studied are not responsible for the ...
2005. The Aspergillus nidulans phytochrome FphA represses sexual development in red light. Curr. Biol. 15:1833-1838. Casselton, L. A. 2002. Mate recognition in fungi. Heredity 88:142- 147. , J. P. Debeaupuis, J. Sarfati, J. Lortholary, P. Ribaud, P. Shah, M. Cornet, H. V. Thien, E. Gluckman, G. Bru ¨cker, and J. P. Latge´. 1998. Molecular typing of environmental and patient isolates of Aspergillus fumigatus from various hospital settings. J. Clin. Microbiol. 36:1494-1500. Debeaupuis, J. , J. Sarfati, V. Momany, T. Tanaka, T. Kumagai, K. Asai, M. Machida, W. C. Nierman, D. W. Denning, M. Caddick, M. Hynes, M. Paoletti, R. Fischer, B. Miller, P. Dyer, M. S. Sachs, S. A. Osmani, and B. W. Birren. 2005. Sequencing and comparative analysis of Aspergillus nidulans. Nature 438:1105-1115. , M. Christensen, A. H. Onions, J. I. Pitt, and R. A. Samson. 1985. Infrageneric taxa of Aspergillus, p. 55-62. In R. A. Samson and J. I. ), Advances in Penicillium and Aspergillus Systematics. Plenum Press, New ...
Horizontal gene transfer (HGT) is a fast-track mechanism that allows genetically unrelated organisms to exchange genes for rapid environmental adaptation. We developed a new phyletic distribution-based software, HGT-Finder, which implements a novel bioinformatics algorithm to calculate a horizontal transfer index and a probability value for each query gene. Applying this new tool to the Aspergillus fumigatus, Aspergillus flavus, and Aspergillus nidulans genomes, we found 273, 542, and 715 transferred genes (HTGs), respectively. HTGs have shorter length, higher guanine-cytosine (GC) content, and relaxed selection pressure. Metabolic process and secondary metabolism functions are significantly enriched in HTGs. Gene clustering analysis showed that 61%, 41% and 74% of HTGs in the three genomes form physically linked gene clusters (HTGCs). Overlapping manually curated, secondary metabolite gene clusters (SMGCs) with HTGCs found that 9 of the 33 A. fumigatus SMGCs and 31 of the 65 A. nidulans SMGCs share
Soil-dwelling fungal species possess the versatile metabolic capability to degrade complex organic compounds that are toxic to humans, yet the mechanisms they employ remain largely unknown. Benzo[a]pyrene (BaP) is a pervasive carcinogenic contaminant, posing a significant concern for human health. Here, we report that several Aspergillus species are capable of degrading BaP. Exposing Aspergillus nidulans cells to BaP results in transcriptomic and metabolic changes associated with cellular growth and energy generation, implying that the fungus utilizes BaP as a growth substrate. Importantly, we identify and characterize the conserved bapA gene encoding a cytochrome P450 monooxygenase that is necessary for the metabolic utilization of BaP in Aspergillus. We further demonstrate that the fungal NF-kappa B-type velvet regulators VeA and VelB are required for proper expression of bapA in response to nutrient limitation and BaP degradation in A. nidulans. Our study illuminates fundamental knowledge of ...
Members of the septin gene family are highly homologous and have been found in several species of fungi and animals where they play critical roles in cytokinesis and cell surface organization (reviewed by Field and Kellogg 1999). Interestingly, septins have not been reported in algae or land plants. It seems most likely that septins arose in a common ancestor of fungi and animals after divergence of the green plants (Wainrightet al. 1993). It is also possible that septins arose in an earlier common ancestor shared by green plants, fungi, and animals and were later lost in the green plant lineage by nonorthologous gene displacement or lineage-specific gene loss. Regardless of the evolutionary path, it is not surprising that septins are present in animals and fungi and absent in plants in view of the major differences in division mechanisms. Animal and fungal cells divide centripetally; that is, the division furrow progresses from the cortex to the interior. Plant cells, however, divide ...
Aspergillus comprises a diverse group of species based on morphological, physiological and phylogenetic characters, which significantly impact biotechnology, food production, indoor environments and human health. Aspergillus was traditionally associated with nine teleomorph genera, but phylogenetic data suggest that together with genera such as Polypaecilum, Phialosimplex, Dichotomomyces and Cristaspora, Aspergillus forms a monophyletic clade closely related to Penicillium. Changes in the International Code of Nomenclature for algae, fungi and plants resulted in the move to one name per species, meaning that a decision had to be made whether to keep Aspergillus as one big genus or to split it into several smaller genera. The International Commission of Penicillium and Aspergillus decided to keep Aspergillus instead of using smaller genera. In this paper, we present the arguments for this decision. We introduce new combinations for accepted species presently lacking an Aspergillus name and ...
The Outcomes and Evidence-based Practice Committee (OEBPC) will facilitate the efforts of APSA members either individually or as an organization to develop clinical outcomes data and evidence-based recommendations relevant to the practice of pediatric surgery. At the request of the APSA membership and/or the BOG of APSA, the OEBPC will serve to identify important areas of clinical guidelines and research in order to formulate and disseminate appropriate recommendations to assist APSA members in their practices. The OEBPC will be a central resource for APSA members to help promote clinical and outcomes research in pediatric surgery. The OEBPC will work collaboratively with other existing APSA committees to identify and address educational and/or programmatic needs and opportunities for the APSA membership as they relate to clinical outcomes. At the request of the APSA membership and/or the BOG of APSA, the OCT Committee will serve to identify important areas of clinical guidelines and research in ...
Sexual spore definition is - a spore formed as a result of conjugation of gametes or nuclei (such as zygospore, ascospore, basidiospore) of opposite sex.
In response to changes in ambient pH the opportunistic pathogen Candida albicans differentially expresses a number of genes. The response to pH affects morphological differentiation and virulence. The pathway controlling the pH response terminates in the zinc-finger containing transcription factor encoded by RIM101/PRR2. By analogy to the pH response pathway of Aspergillus nidulans, PRR1 of C. albicans encodes a protein that is presumably required to convert Rim101p from an inactive to an active form by proteolytic removal of a C-terminal peptide. A prr1Delta mutant is compromised in its ability to differentiate into the filamentous form. Spontaneous phenotypic revertants of a prr1Delta mutant were selected by their ability to form filamentous colonies. These mutants were also found to be defective in pH-dependent gene expression. Each of the eight mutants examined contained a heterozygous dominant mutation at the RIM101 locus. This was demonstrated genetically in all of the mutants, and ...
S cerevisiae SST2 protein: a regulator of G-protein signalling (RGS); promotes recovery after pheromone-induced growth arrest in Saccharomyces cerevisiae; has 30% amino acid sequence identity with Aspergillus nidulans flbA protein
Viral DNA-binding proteins have served as good models to study the biochemistry of transcription regulation and chromatin dynamics. Computational analysis of viral DNA-binding regulatory proteins and identification of their previously undetected homologs encoded by cellular genomes might lead to a better understanding of their function and evolution in both viral and cellular systems. The phyletic range and the conserved DNA-binding domains of the viral regulatory proteins of the poxvirus D6R/N1R and baculoviral Bro protein families have not been previously defined. Using computational analysis, we show that the amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain is suggested to be homologous to the fungal DNA-binding APSES domain. We provide evidence for the KilA-N and APSES domains sharing a common fold with the nucleic acid-binding
1. The strict photoautotrophic blue-green alga, Anacystis nidulans, has a high requirement for manganese; its absence from the culture medium causes significant changes in the morphology and the...
Carbon catabolite repression (CCR) is a mechanism by which micro-organisms preferentially utilize more easily metabolizable carbon sources in comparison to less easily metabolizable carbon sources. It prevents the organisms from unnecessary expenditure of energy and enables them to exploit the nutrients in appropriate manner. It represents a complex system of gene regulation. The main aim of this study was to study the intracellular localization of proteins involved in CCR including CreA, CreB, CreC and CreD in A. nidulans in repressing and derepressing conditions. The major regulatory protein involved in CCR in A. nidulans is CreA. It is a DNA-binding repressor, but very little is known about the molecular events that allow CreA function to result in appropriate regulation in response to carbon source. To determine the amount and localization of CreA in different carbon sources, strains were made over-expressing GFP and HA tagged CreA. Western analysis showed that high levels of full length ...
mycelium thin, dense, white. Appressoria indistinct, sometimes nipple-shaped, never lobed. Conidia in rather long chains, without fibrosin bodies. Foot-cell of conidiophore straight, 70-130 µm long, followed by 1-2 shorter cells. Cleistothecia unknown. ...
Digital Morphology account of the razorbill, Alca torda, featuring CT-generated animations of the skull and expert commentary by Dr. N. Adam Smith
i want to know about effectiveness of AMWAY PRODUCT APSA 80 IF somebody have used it i want to know that the how much you think it is effective?
Qute Balance Forskolin Extract is a natural formula that improves metabolism and weight loss without the requirement of changing diet or exercise routine.
ANCF - Adjusted Net Cash Flow. Looking for abbreviations of ANCF? It is Adjusted Net Cash Flow. Adjusted Net Cash Flow listed as ANCF
LITIO ESTABILIZADOR DEL ANIMO PDF - Un estudio de diseño abierto comparó la quetiapina con el litio como adyuvantes minalcipram o fluvoxamina; n=35) o estabilizadores del ánimo (litio o
Sichtbehinderung durch Nebel kann einen geplanten Flug verunmöglichen. Die Kenntnis der Aussagekraft von Flugwetterinformationen ist deshalb fundamental.
These fungal strains [Aspergillus oryzae FNBR_L35; Fusarium sp. FNBR_B7, FNBR_LK5 and FNBR_B3; Aspergillus nidulans FNBR_LK1; ... The fungus Aspergillus sclerotiorum CBMAI 849 showed the best performance with regard to pyrene (99.7%) and benzo[a]pyrene ( ... Aspergillus niger recorded maximum decolorization of the dye Basic fuchsin (81.85%) followed by Nigrosin (77.47%), Malachite ... A variety of fungi, such as Pleurotus, Aspergillus, Trichoderma has proven to be effective in the removal of lead, cadmium, ...
... nidulans/latest_assembly_versions/GCF_000149205.2_ASM14920v2". ftp.ncbi.nih.gov. Retrieved 2020-12-30. "Aspergillus nidulans ( ... "Aspergillus niger (ID 429) - Genome - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-12-14. "Index of /genomes/refseq/fungi/ ... "Index of /genomes/refseq/fungi/Aspergillus_niger/latest_assembly_versions/GCF_000002855.3_ASM285v2". ftp.ncbi.nih.gov. ...
In Aspergillus nidulans and Aspergillus heterothallicus Hülle cells associate with the cleistothecia, whereas in Aspergillus ... Different species of the genus Aspergillus produce Hülle cells, including Aspergillus nidulans and Aspergillus heterothallicus ... Carvalho, F. (2002). "An investigation of the nuclei of Hülle cells of Aspergillus nidulans". Genetics and Molecular Biology. ... vary in shape between the more elongated such as in Aspergillus ustus and the globose version like in Aspergillus nidulans. ...
The proteins were first characterized in Aspergillus nidulans. Some proteins in the complex are light-sensitive, including the ... Amare, MG; Keller, NP (May 2014). "Molecular mechanisms of Aspergillus flavus secondary metabolism and development". Fungal ...
Aspergillus nidulans produces sterigmatocystin - a precursor to aflatoxins. Aspergillus was found to have horizontally ... Aspergillus to Podospora represents a large metabolic gene transfer which could have contributed to fungal metabolic diversity ... Podospora and Aspergillus show high conservation and microsynteny sterigmatocystin/aflatoxin clusters along with intergenic ... Sterigmatocystin gene transfer has been observed with Podospora anserina and Aspergillus. Horizontal gene transfer in ...
They characterized all Fur proteins in Aspergillus nidulans. Homology modelling, substrate docking, molecular dynamics and ...
Hynes MJ (1994). "Regulatory circuits of the amdS gene of Aspergillus nidulans". Antonie van Leeuwenhoek. 65 (3): 179-82. doi: ... Other important model fungi are Aspergillus nidulans and the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, ... Aspergillus oryzae and Aspergillus sojae". Journal of Food Protection. 70 (12): 2916-34. doi:10.4315/0362-028X-70.12.2916. PMID ... Shoyu koji mold (Aspergillus oryzae) is an essential ingredient in brewing Shoyu (soy sauce) and sake, and the preparation of ...
Chromosome-specific recombinant DNA libraries from the fungus Aspergillus nidulans. Nucleic Acids Res. 1991 Jun 11;19(11):3105- ... it was possible to quickly map the genome of Aspergillus nidulans. This was one of the first genomes physically mapped In ... In vitro reconstruction of the Aspergillus (= Emericella) nidulans genome. Proc. Natl. Acad. Sci. USA 94 (1997), pp. 14564- ...
In a study concerning Aspergillus nidulans, it was found that with the inhibition of a methylcitrate synthase gene, mcsA, of ... "Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans". Genetics. 168 (2): 785-94. doi: ...
In Aspergillus nidulans NPC composition appears to be effected by the mitotic kinase NIMA, possibly by phosphorylating the ... In organisms that undergo a semi-open mitosis such as the filamentous fungus Aspergillus nidulans, 14 out of the 30 ... "Partial Nuclear Pore Complex Disassembly during Closed Mitosis in Aspergillus nidulans". Current Biology. 14 (22): 1973-1984. ...
... is a fermentation product of Aspergillus nidulans and the closely related species, A. rugulosus; discovered in ... Echinocandin B, a novel polypeptide-antibiotic from Aspergillus nidulans var. echinulatus: isolation and structural components ... 1974 in A. nidulans var. echinulatus strain A 32204 in Germany, it was the first of the echinocandin class of antifungals. ...
... is mainly produced by the fungi Aspergillus nidulans and A. versicolor. It has been reported in mouldy grain, ... Sterigmatocystin is a polyketide mycotoxin produced by certain species of Aspergillus. The toxin is naturally found in some ... loss of milk production and in some cases death were found to have ingested feed containing Aspergillus versicolor and high ...
"Distinct Ceramide Synthases Regulate Polarized Growth in the Filamentous Fungus Aspergillus nidulans". Molecular Biology of the ...
Deletion of the rid homolog in Aspergillus nidulans, dmtA, results in loss of fertility while deletion of the rid homolog in ... "A cytosine methyltransferase homologue is essential for sexual development in Aspergillus nidulans". PLOS ONE. 3 (6): e2531. ...
His name is associated with the mycological species Aspergillus delacroixii (synonym, Aspergillus nidulans var. echinulatus). ... "Recurrent prosthetic valve endocarditis caused by Aspergillus delacroxii (formerly Aspergillus nidulans var. echinulatus)". Med ...
In Aspergillus nidulans, the TEA domain protein ABAA regulates the differentiation of conidiophores. In drosophila the ... "Isolation and physical characterization of three essential conidiation genes from Aspergillus nidulans". Molecular and Cellular ... TEAD proteins were notably found in Drosophila (Scalloped), C. elegans (egl -44), S. cerevisiae and A. nidulans. TEAD2 has been ...
Thus Aspergillus niger is considered a form taxon. In contrast, isolates of its close relative, Aspergillus nidulans, revealed ... of Penicillium are used to improve both the taste and the texture of cheeses Aspergillus oryzae Aspergillus sojae Aspergillus ... Hence the formerly classified Aspergillus species is now properly called Emericella nidulans. Phylogenetic classification of ... For example, the ubiquitous and industrially important mold, Aspergillus niger, has no known sexual cycle. ...
Its biosynthetic pathway has been determined in the filamentous fungus Aspergillus nidulans. Aspergillus versicolor Hines J, ... Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor". ...
In Aspergillus nidulans, the TEA domain protein ABAA regulates the differentiation of conidiophores. In drosophila the ... "Isolation and physical characterization of three essential conidiation genes from Aspergillus nidulans". Molecular and Cellular ...
... uvsH diploid strain of Aspergillus nidulans". Anais da Academia Brasileira de Ciências. 76 (1): 49-55. doi:10.1590/S0001- ...
"Depression of the xylanase-encoding cgxA gene of Chaetomium gracile in Aspergillus nidulans". Microbiological Research. 153 (4 ...
December 2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 ( ...
"Arp11 affects dynein-dynactin interaction and is essential for dynein function in Aspergillus nidulans". Traffic. 9 (7): 1073- ...
Restricting colony expansion in Aspergillus nidulans in microbiology. *Decellularization of animal-derived tissues ...
"Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans". Current Biology. 17 (16): 1384-9 ... Selfing in the homothallic fungus Aspergillus nidulans involves activation of the same mating pathways characteristic of sex in ... Among those Aspergillus species for which a sexual cycle has been observed, the majority in nature are homothallic (self- ... Dyer PS, O'Gorman CM (January 2012). "Sexual development and cryptic sexuality in fungi: insights from Aspergillus species". ...
"Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans". Current Biology. 17 (16): 1384-9 ... Selfing in the homothallic fungus Aspergillus nidulans involves activation of the same mating pathways characteristic of sex in ... Among those Aspergillus species that exhibit a sexual cycle the overwhelming majority in nature are homothallic (self- ... Dyer PS, O'Gorman CM (2012). "Sexual development and cryptic sexuality in fungi: insights from Aspergillus species". FEMS ...
"Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans". Current Biology. 17 (16): 1384-9 ... Selfing in the homothallic fungus Aspergillus nidulans involves activation of the same mating pathways characteristic of sex in ... Among the 250 known species of aspergilli, about 36% have an identified sexual state Among those Aspergillus species that ... Dyer PS, O'Gorman CM (January 2012). "Sexual development and cryptic sexuality in fungi: insights from Aspergillus species". ...
QSMs have been studied in Candida albicans, C. dubliniensis, Aspergillus niger, A. nidulans, and Fusarium graminearum. QSMs can ...
Yoshimoto A, Nakamura T, Sato R (December 1967). "Isolation from Aspergillus nidulans, of a protein catalyzing the reduction of ...
42% similarity with the orsellinic acid synthase gene (OrsA) in Aspergillus nidulans. Characterization of the gene proved it to ...
Emericella nidulans (pohlavné rozmnožovanie askospórami). Aspergillus nidulans (nepohlavné rozmnožovanie konídiami) Druh je ... Dovičičová M. (2010): Štúdium potenciálne toxinogénnych druhov rodu Aspergillus a asociovaných teleomorf izolovaných zo zrna ... Rod Aspergillus (Pitt et Hocking, 1999) bol prvýkrát opísaný v roku 1729 talianskym kňazom a mykológom Pierom Antoniom Michelim ... Aspergillus fumigatus (nepohlavné rozmnožovanie konídiami) Druh je heterothalický:. a) v prípade zhodnej časovej a priestorovej ...
... სხვა ფილამენტური სოკოებიდან იშვიათად გვხვდება Aspergillus flavus, Aspergillus nidulans, Exophiala dermatitidis და Scedosporium ... მათ შორისაა ბრონქოპულმონარული ასპერგილოზი, როდესაც ორგანიზმის საპასუხო რეაქცია სოკო Aspergillus fumigatus-ის მიმართ იწვევს ... CF პაციენტების ჰაერგამტარი გზები ასევე შეიძლება იყოს კოლონიზებული ფილამენტური სოკოთი (როგორიცაა Aspergillus fumigatus, ... Scedosporium apiospermum, Aspergillus terreus) და/ან საფუარები (როგორიცაა Candida albicans); ...
"ATP-Citrate Lyase Is Required for Production of Cytosolic Acetyl Coenzyme A and Development in Aspergillus nidulans". ...
... latus Thom & Raper 1939. Emericella nidulans (Eidam) Vuill. 1927. Diplostephanus nidulans (Eidam) Langeron ... Sterigmatocystis nidulans nicollei Pinoy 1906. Sterigmatocystis nidulans Eidam 1883. Aspergillus nidulans nicollei (Pinoy) ... Aspergillus nidulellus Samson & W. Gams 1986. Emericella nidulans lata (Thom & Raper) Subram. 1972. Emericella nidulans ... An Aspergillus nidulans in nahilalakip ha genus nga Aspergillus, ngan familia nga Trichocomaceae.[2][3] ...
Aspergillus nidulans 30.000.000 30Mb Nematodo Caenorhabditis elegans 100.300.000 100Mb Primeiro xenoma de animal pluricelular ...
Aspergillus nidulans. *Coprinus cinereus (seente arengu ja meioosi geneetilised uuringud). *Cunninghamella elegans on seenmudel ...
Aspergillus glaucus. Aspergillus lentulus. Aspergillus nidulans. Aspergillus niger. Aspergillus ochraceus. Aspergillus oryzae. ... Aspergillus restrictus. Aspergillus sojae. Aspergillus sydowii. Aspergillus tamari. Aspergillus terreus. Aspergillus ustus. ... Aspergillus alliaceus. Aspergillus caesiellus. Aspergillus caespitosus. Aspergillus candidus. Aspergillus carneus. Aspergillus ... Aspergillus deflectus. Aspergillus egyptiacus. Aspergillus fischerianus. Aspergillus flavus. Aspergillus foetidus. Aspergillus ...
Regulatory circuits of the amdS gene of Aspergillus nidulans. Antonie van Leeuwenhoek. 1994, 65 (3): 179-82. PMID 7847883. doi: ... Identification and toxigenic potential of the industrially important fungi, Aspergillus oryzae and Aspergillus sojae. Journal ... Abe K, Gomi K, Hasegawa F, Machida M. Impact of Aspergillus oryzae genomics on industrial production of metabolites. ... Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants. Current ...
பூஞ்சை, Aspergillus nidulans 30,000,000 Nematode, Caenorhabditis elegans 98,000,000 First multicellular animal genome, December ...
The genome sequences of three Aspergillus species-Aspergillus fumigatus, Aspergillus nidulans, and Aspergillus oryzae-were ... Aspergillus fumigatus is a species of fungus in the genus Aspergillus, and is one of the most common Aspergillus species to ... The Aspergillus Trust A registered UK charity engaged in support of sufferers of aspergillus disease worldwide and research ... "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 (7071): 1105-15. ...
The starting material is echinocandin B (a lipopeptide fermentation product of Aspergillus nidulans or the closely related ... It was previously known as LY303366.[3][4][5] It may also have application in treating invasive Aspergillus infection when used ...
It is very rarely caused by Aspergillus flavus, Aspergillus oryzae, Aspergillus terreus or Aspergillus nidulans. Patients with ... Serum precipitins for aspergillus (blood test to detect antibodies to aspergillus) Almost all aspergillomas are caused by ... is a long-term aspergillus infection of the lung and Aspergillus fumigatus is almost always the species responsible for this ... Aspergillus nodule Chronic cavitary pulmonary aspergillosis (CCPA) where cavities are present in the lungs, but not necessarily ...
Aspergillus nidulans and Emericella nidulans, for asexual and sexual isolates, respectively, of the same species. ... In Asia, Aspergillus oryzae is added to a pulp of soaked soya beans to make soy sauce, and is used to break down starch in rice ... Most famously, Neurospora crassa, several species of yeasts, and Aspergillus species are used in many genetics and cell biology ... Aspergillus flavus, which grows on peanuts and other hosts, generates aflatoxin, which damages the liver and is highly ...
Aspergillus nidulans Strain:FGSC A4, model organism (2005[20]). *Aspergillus niger Strain:ATCC 1015 (DOE Joint Genome institute ... Aspergillus oryzae Strain:RIB40, industrial use (2005[22]). *Aspergillus terreus NIH 2624, statin producer and pathogen (2005, ... "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 (7071): 1105-15. ... "Home - Aspergillus carbonarius ITEM 5010 v3". genome.jgi-psf.org. Retrieved 24 November 2018.. ...
Eckert SC, Kubler E, Hoffmann B, Braus GH (June 2000). "The tryptophan synthase-encoding trpB gene of Aspergillus nidulans is ...
... including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth & ...
December 2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 ( ... Aspergillus oryzae, known in English as koji (Japanese: 麹, Hepburn: kōji), is a filamentous fungus (a mold) used in Chinese and ... Fujita, Chieko, Tokyo Foundation Koji, an Aspergillus *^ Shurtleff, W.; Aoyagi, A. History of Koji - Grains and/or Soybeans ... Aspergillus oryzae genome from the Database of Genomes Analysed at NITE (DOGAN) ...
... while fungi such as Aspergillus nidulans and Saccharomyces cerevisiae (yeast) undergo a "closed" mitosis, where chromosomes ...
Aspergillus neoindicus Aspergillus neoniger Aspergillus neoniveus Aspergillus nidulans Aspergillus nidulellus Aspergillus niger ... U V W X Y Z Aspergillus racemosus Aspergillus raianus Aspergillus rambellii Aspergillus ramosus Aspergillus raperi Aspergillus ... recurvatus Aspergillus rehmii Aspergillus repandus Aspergillus repens Aspergillus reptans Aspergillus restrictus Aspergillus ... U V W X Y Z Aspergillus acidus Aspergillus aculeatinus Aspergillus aculeatus Aspergillus aeneus Aspergillus affinis Aspergillus ...
... aspergillus fumigatus MeSH B05.381.081.420 - aspergillus nidulans MeSH B05.381.081.450 - aspergillus niger MeSH B05.381.081.480 ... aspergillus ochraceus MeSH B05.381.081.500 - aspergillus oryzae MeSH B05.381.125 - blastomyces MeSH B05.381.128 - botrytis MeSH ... aspergillus MeSH B05.381.081.170 - aspergillus flavus MeSH B05.381.081.295 - ...
Trichoderma reesei and Aspergillus nidulans, Neurospora crassa, Cryptococcus neoformans, Ustilago maydis Plants: Arabidopsis ...
Brodhun F, Göbel C, Hornung E, Feussner I (May 2009). "Identification of PpoA from Aspergillus nidulans as a fusion protein of ...
... including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): ...
Aspergillus nidulans (also called Emericella nidulans when referring to its sexual form, or teleomorph) is one of many species ... 2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 (7071): 1105- ... "Aspergillus nidulans Project Information". Broad Institute. Retrieved 2011-01-28. CS1 maint: discouraged parameter (link) ... Echinocandin B, a novel polypeptide-antibiotic from Aspergillus nidulans var. echinulatus: isolation and structural components ...
Aspergillus nidulans. Definition. Aspergillus nidulans is a filamentous soil fungus in the phylum Ascomcyetes. It is a fungal ... Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans *Kirstin Scherlach ... its sexual form or teleomorph is known as Emericella nidulans. ...
crnA encodes a nitrate transporter in Aspergillus nidulans - May 15, 1991. *crnA encodes a nitrate transporter in Aspergillus ... crnA encodes a nitrate transporter in Aspergillus nidulans. S E Unkles, K L Hawker, C Grieve, E I Campbell, P Montague, J R ... crnA encodes a nitrate transporter in Aspergillus nidulans. S E Unkles, K L Hawker, C Grieve, E I Campbell, P Montague, J R ... crnA encodes a nitrate transporter in Aspergillus nidulans. S E Unkles, K L Hawker, C Grieve, E I Campbell, P Montague, and J R ...
... PLEASE HELP domflag at istar.ca Fri Feb 21 15:55:46 EST 1997 *Previous message: Will NIH ... Infection: Aspergillus Nidulans in the Central Nervous System. The fungus surrounds the base of the brain and is present in ... the biopsy confirmed the fungus was Aspergillus, but the cultures would not grow so it could not be confirmed the fungus was ... Nidulans. An MRI taken February 3, 1997 has shown that the fungus increased in size considerably even with this teatment and ...
Aspergillus nidulans ATCC ® 24766™ Designation: FGSC A158 (ribo1 bi1) Application: Biomedical Research and Development Material ... Aspergillus nidulans (Eidam) Winter (ATCC® 24766™) Alternate State: Emericella nidulans (Eidam) Vuillemin / Strain Designations ... The genetics of Aspergillus nidulans. Adv. Genet. 5: 142-238, 1953. Barratt RW, et al. Wild-type and mutant stocks of ... Aspergillus nidulans. Genetics 52: 233-246, 1965. PubMed: 5857598 Roper JA. Search for linkage between genes determining a ...
Genomic DNA from Aspergillus nidulans strain G00 [ATCC ® 38163™] Application: ... Aspergillus nidulans (Eidam) Winter (ATCC® 38163D-2™) Alternate State: Emericella nidulans (Eidam) Vuillemin / Strain ... Nucleotide (GenBank) : AACD01000000 Aspergillus nidulans FGSC A4, whole genome shotgun sequencing project. ... Genomic DNA from Aspergillus nidulans strain G00 [ATCC® 38163™] / Product Format: dried Total DNA: Approximately 2 µg of DNA. ...
2000 Landmarks in the early duplication cycles of Aspergillus fumigatus and Aspergillus nidulans: polarity, germ tube emergence ... In Aspergillus nidulans, a brief period of isotropic growth is followed by apical extension of the germ tube (reviewed by H ... 1997 The Aspergillus nidulans septin encoding gene, aspB, is essential for growth. Fungal Genet. Biol. 21: 92-100. ... 1998 hyp loci control cell pattern formation in the vegetative mycelium of Aspergillus nidulans. Genetics 148: 669-680. ...
A. nidulans was the first Aspergillus species to have its entire genome sequenced, and considering that A. nidulans is sexually ... www.researchgate.net/figure/Aspergillus-nidulans-var-nidulans-a-e-Teleomorph-and-f-h-Anamorph-a-Ascomata_fig2_259390442 [ ... Aspergillus nidulans. From MicrobeWiki, the student-edited microbiology resource. Revision as of 00:50, 29 January 2020 by ... The use of A. nidulans as a model species allows for the understanding of other Aspergillus species (e.g., A. niger, A. oryzea ...
Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans.. Szewczyk E1, Chiang YM, Oakley CE ... Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans Appl Environ Microbiol. 2008 Dec;74 ... Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans Appl Environ Microbiol. 2008 Dec;74 ... Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans Appl Environ Microbiol. 2008 Dec;74 ...
... the attempts being made to trigger the activation of polyketide metabolism in the fungal model organism Aspergillus nidulans. ... Aspergillus nidulans secondary metabolites; polyketides; polyketide synthases; gene clusters; biosynthesis; Aspergillus ... "Genetics of Polyketide Metabolism in Aspergillus nidulans." Metabolites 2, no. 1: 100-133. ... Genetics of Polyketide Metabolism in Aspergillus nidulans. Metabolites. 2012; 2(1):100-133. ...
Martinelli, S. D., 1994 Aspergillus nidulans as an experimental organism, pp. 33-58 in Aspergillus: 50 Years On (Progress in ... Adams, T. H., J. K. Wieser and J.-H. Yu, 1998 Asexual sporulation in Aspergillus nidulans. Microbiol. Mol. Biol. Rev. 62: 35-54 ... Pontecorvo, G., J. A. Roper, L. M. Hemmons, K. D. Macdonald and A. W. J. Bufton, 1953 The genetics of Aspergillus nidulans. Adv ... Felenbok, B., D. Sequeval, M. Mathieu, S. Sibley, D. I. Gwynne et al., 1988 The ethanol regulon in Aspergillus nidulans: ...
Nuclear movement is beta--tubulin-dependent in Aspergillus nidulans.. Oakley BR, Morris NR. ...
... Margelis S., DSouza C., Small A.J., ... We have isolated the Aspergillus nidulans glnA gene encoding GS and have shown that glnA encodes a highly expressed but not ... However, the A. nidulans fluG gene, which encodes a protein with similarity to prokaryotic GS, did not replace A. nidulans glnA ... Heterologous expression of the prokaryotic Anabaena glnA gene from the A. nidulans alcA promoter allowed full complementation ...
Here, we used whole genome DNA microarrays to investigate global transcriptional changes in Aspergillus... ... Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp. Fungal Genet Biol 46 ... Barratt RW, Johnson GB, Ogata WN (1965) Wild-type and mutant stocks of Aspergillus nidulans. Genetics 52:233-246PubMedGoogle ... David H, Ozçelik IS, Hofmann G, Nielsen J (2008) Analysis of Aspergillus nidulans metabolism at the genome-scale. BMC Genomics ...
Homocysteine is an intermediate in methionine synthesis in Aspergillus nidulans, but it can also be converted to cysteine by ... Aspergillus nidulans Transsulfuration Cystathionine β-synthase Cystathionine γ-lyase Regulation by homocysteine ... Pontecorvo G, Roper JA, Hemmons LM, Macdonald KD, Bufton AW (1953) The genetics of Aspergillus nidulans. Adv Genet 5:141-238 ... Natorff R, Sieńko M, Brzywczy J, Paszewski A (2003) The Aspergillus nidulans metR gene encodes a bZIP protein which activates ...
Isolation of a sexual sporulation hormone from Aspergillus nidulans. Message Subject (Your Name) has forwarded a page to you ... Isolation of a sexual sporulation hormone from Aspergillus nidulans.. S P Champe, A A el-Zayat ...
... has been isolated from Aspergillus nidulans. This single-copy gene has an open reading frame (ORF) of 6864 bp and contains two ... Isolation and characterisation of the acetyl-CoA carboxylase gene from Aspergillus nidulans Curr Genet. 1998 Dec;34(5):379-85. ... The putative gene encoding acetyl-CoA carboxylase, accA, has been isolated from Aspergillus nidulans. This single-copy gene has ... Deletion of accA in A. nidulans was unsuccessful. The failure of A. nidulans to grow in the presence of the ACC-specific ...
... the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to ... the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to ... Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlings Microbiology. 1999 Nov;145 ( Pt 11): ... Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase ...
Immobilization and Biochemical Properties of the Enantioselective Recombinant NStcI Esterase of Aspergillus nidulans. Figure 2 ...
List of A. nidulans strains used in this study. Table S2. List of primers used in this study. Table S3. Unique significant ... Most enriched GO terms among DEGs induced by salt stress in wild-type A. nidulans. For each enriched GO term with a Bonferroni ... KEGG pathway enrichment of DEGs induced by salt stress in wild-type A. nidulans. The x-axis indicates the enrichment factor of ... Analysis Reveals Genes Mediating Salt Tolerance through Calcineurin/CchA-Independent Signaling in Aspergillus nidulans. Sha ...
... Author(s). Swart, K.; Slakhorst, M.; ...
... and of the precise sites of exocytosis and endocytosis at the growing hyphal tip by using the model fungus Aspergillus nidulans ... The Tip Growth Apparatus of Aspergillus nidulans. Molecular Biology of the Cell, 19(4), 1439-1449. http://www.dx.doi.org/ ...
... from Aspergillus nidulans to perfom BLAST searches at the public A. nidulans genome database, at the Whitehead Center for ... In der vorliegenden Arbeit wurde das kinesin-ähnliche Protein, KipB, in Aspergillus nidulans untersucht. KipB gehört zur ... The present work analyses the function of a kinesin-like protein in A. nidulans, KipB, which is a member of the Kip3 kinesin ... To assess the function of KipB kinesin in A. nidulans, a kipB disruption strain was constructed. Analysis of the DkipB mutant ...
Aspergillus fumigatus, Aspergillus nidulans, Aspergillus oryzae, Base Sequence, Consensus Sequence, Conserved Sequence, ... Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus ... Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.. ... fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake, miso and soy sauce. Our analysis ...
Transport Assays in Aspergillus nidulans. Transport assays allow the direct kinetic analysis of a specific transporter by ... How to cite this protocol: Krypotou, E. and Diallinas, G. (2013). Transport Assays in Aspergillus nidulans. Bio-protocol 3(22 ... Vlanti, A. and Diallinas, G. (2008). The Aspergillus nidulans FcyB cytosine-purine scavenger is highly expressed during ... we describe a rapid and easy method for performing uptake assays in the model filamentous ascomycete Aspergillus nidulans. ...
A Method for the Selection of Deletion Mutations in the L-Proline Catabolism Gene Cluster of Aspergillus nidulans - Volume 38 ... Bailey, C. R. (1977). The regulation of carbon metabolism in Aspergillus nidulans. In Genetics and Physiology of Aspergillus ( ... Pontecorvo, G., Roper, J. A., Hemmons, L. M., Macdonald, K. D. & Bufton, A. W. J. (1953). The genetics of Aspergillus nidulans ... Arst, H. N. Jr., Macdonald, D. W. & Jones, S. A. (1980 b). Regulation of proline transport in Aspergillus nidulans. Journal of ...
Aspergillus Sequencing Project, Broad Institute/MIT Center for Genome Research. Central Aspergillus Data REpository (CADRE) ... The Aspergillus nidulans Linkage Map. Linkage Data, Maps, Locus Lists, Strainlist and Annual Bibliographies. Compiled by John ... The original linkage maps were published as illustrations to "The Validity of the Aspergillus nidulans Linkage Map" in Fungal ... Gene lists include, as far as possible, all publishedAspergillus (Emericella) nidulans genes, and where available, Genbank ...
... of Aspergillus nidulans hyphae and sexual spores. A. nidulans (also known as Emericella nidulans) is a filamentous fungus that ... as well as metabolism of other Aspergillus species. A. nidulans produces the toxin, sterigmatocysin, which may lead to food ... A. nidulans. has been an important research organism for studying eukaryotic cell biology and has a long history of use for the ... nidulans is also a homothallic fungus, meaning it can form asexual spores by producing conidiphores that bear chains of asexual ...
Production of terpenes with Aspergillus nidulans.. Kiira Vuoristo, Kirsi Bromann, Mervi Toivari, Laura Ruohonen, Tiina Nakari- ... been widely used in industrial scale production of various compounds and especially Aspergillus niger and Aspergillus nidulans ... Please note: The Aspergillus Website does not accept advertisments. , all content is published on merit. BB.com. Site Sponsors ... Aspergillus Website Newsletters. Our most recent newsletters (since August 2018) can be found here. ...
A chimeric protein was obtained by fusing together the ricin toxin A chain (RTA) gene and a DNA fragment encoding the N terminus… (More) ...
  • A. nidulans is a homothallic fungus, meaning it is able to self-fertilize and form fruiting bodies in the absence of a mating partner. (wikipedia.org)
  • Aspergillus nidulans is a filamentous soil fungus in the phylum Ascomcyetes. (nature.com)
  • the biopsy confirmed the fungus was Aspergillus, but the cultures would not grow so it could not be confirmed the fungus was Nidulans. (bio.net)
  • Five septin genes have been cloned and sequenced from the model filamentous fungus A. nidulans . (genetics.org)
  • Although the developmental activator FluG was shown to be necessary for activation of asexual sporulation (conidiation) and production of the carcinogenic mycotoxin sterigmatocystin (ST) in the model filamentous fungus Aspergillus nidulans , the molecular mechanisms underlying the developmental switch have remained elusive. (genetics.org)
  • Brody H, Griffith J, Cuticchia AJ, Arnold J, Timberlake WE (1991) Chromosome-specific recombinant DNA libraries from the fungus Aspergillus nidulans . (springer.com)
  • Cove DJ (1966) The induction and repression of nitrate reductase in the fungus Aspergillus nidulans . (springer.com)
  • To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. (nih.gov)
  • We have investigated the central questions of the roles of cytoskeletal elements and of the precise sites of exocytosis and endocytosis at the growing hyphal tip by using the model fungus Aspergillus nidulans. (ku.edu)
  • A. nidulans (also known as Emericella nidulans) is a filamentous fungus that is the only member of the genus Aspergillus that forms sexual spores through meiosis (seen here in this image as large spores). (sciencephoto.com)
  • A. nidulans is also a homothallic fungus, meaning it can form asexual spores by producing conidiphores that bear chains of asexual spores. (sciencephoto.com)
  • In this study, several aspects of nitrate assimilation and transport have been studied using the filamentous fungus Aspergillus nidulans, which has been shown to be safe laboratory organism as judged by it's pathogenicity towards insect larvae. (aspergillus.org.uk)
  • We have developed an efficient system for amplifying genes from a target fungus, placing them under control of a regulatable promoter, transferring them into A. nidulans and expressing them. (ku.edu)
  • In this study, we designed three regulation strategies for laccase gene expression in the model fungus Aspergillus nidulans . (springer.com)
  • By introducing various promoters in front of the laccase gene pslcc from the white-rot fungus Pycnoporus sanguineus , we found that the laccase gene with the original promoter had effective expression in A. nidulans . (springer.com)
  • Taken together, these results not only demonstrate an efficient system for heterologous protein production in the model fungus A. nidulans but also provide a general approach to applying regulatory methods to control gene expression. (springer.com)
  • This makes A. nidulans the first fungus in which all members of individual Pmt subfamilies can be deleted without loss of viability. (pubmedcentralcanada.ca)
  • Two Aspergillus nidulans genes, xlnA and xlnB, encoding the X22 and X24 xylanases from this fungus, respectively, have been cloned and sequenced. (asm.org)
  • We have used an Aspergillus nidulans macroarray carrying sequences of 2,787 genes from this fungus to monitor gene expression of both wild-type and uvsB ATR (the homologue of the ATR gene) deletion mutant strains in a time course exposure to camptothecin (CPT). (unl.edu)
  • We report here probable nutrient-sensing signal transduction pathways in Aspergillus nidulans, a model filamentous fungus, based on sequence homology studies with known Saccharomyces cerevisiae and Schizosaccharomyces pombe proteins. (iospress.com)
  • Aspergillus nidulans is a filamentous fungus of considerable biological interest which provides an excellent model system for investigating different aspects of drug resistance in filamentous fungi. (asm.org)
  • Aspergillus is able to secrete enzymes that can hydrolyse polysaccharides into pentoses and hexoses [ 1 ], which can be taken up by the fungus. (biomedcentral.com)
  • The filamentous fungus Aspergillus nidulans senses red using the red light receptor, phytochrome (FphA). (kit.edu)
  • Aspergillus rugulosus is a species of fungus in the genus Aspergillus. (wikipedia.org)
  • Inducible alkyltransferase DNA repair proteins in the filamentous fungus Aspergillus nidulans. (openrepository.com)
  • We have investigated the response of the filamentous fungus Aspergillus nidulans to low, non-killing, doses of the alkylating agent MNNG (N-methyl-N'-nitro-N-nitrosoguanidine). (openrepository.com)
  • The first global genomic, proteomic, and secondary metabolomic characterization of the filamentous fungus Aspergillus nidulans following growth onboard the International Space Station (ISS) is reported. (cdc.gov)
  • To address our hypotheses , we have studied fungi and cell wall material properties of the model fungus , Aspergillus nidulans , under autophagic conditions . (umbc.edu)
  • Antibiofilm, antiproliferative, antioxidant and antimutagenic activities of an endophytic fungus aspergillus fumigatus From Moringa oleifera. (greenmedinfo.com)
  • In this study we examined whether adaptation, measured as an increased mycelial growth rate, has correlated responses in the filamentous fungus Aspergillus nidulans with several other metric characters that could be important fitness components (colony forming units, germination speed, and biomass formation). (wur.nl)
  • A mutant that presents increased production of the melanin pigment was isolated from the Aspergillus nidulans fungus. (unesp.br)
  • The attainment of this pigment, in its pure form, has taken biotechnological interest due to its use in cosmetic formulations, mainly for its photoprotector and antioxidant property .Considering the pharmacological potential of the melanin pigment, this study aims to make the structural and functional characterization of the pigment extracted from A. nidulans fungus. (unesp.br)
  • The results of mass spectrometry indicate that the melanin structure of the A. nidulans fungus is composed of two large units, represented by the fragments of molecular mass equal to 573 and 550, with dihydroxyindole groups and substituted pyrrolic rings. (unesp.br)
  • The cytotoxicity assays have shown that the melanin extracted from the A. nidulans fungus does not cause significant damages to the cellular components, before and after metabolization. (unesp.br)
  • Aspergillus nidulans is a filamentous fungus whose cells have highly polarized growth. (usask.ca)
  • Since the 1950s, Aspergillus nidulans has been used as a model fungus ( 4 ) and has advanced the understanding of eukaryotic cellular physiology and genetics. (pnas.org)
  • Aspergillus nidulans (also called Emericella nidulans when referring to its sexual form, or teleomorph) is one of many species of filamentous fungi in the phylum Ascomycota. (wikipedia.org)
  • its sexual form or teleomorph is known as Emericella nidulans. (nature.com)
  • Gene lists include, as far as possible, all published Aspergillus (Emericella) nidulans genes, and where available, Genbank accession numbers and the closest fitting autocalled genes from the Broad Institute genome sequence. (fgsc.net)
  • Make an adhesive tape preparation of Emericella nidulans (Cleistothecia) substituting KOH for LPCB. (blogspot.com)
  • A. nidulans is capable of producing sexual spores via meiosis, which allows for a more diversified collection of strains for the species. (kenyon.edu)
  • The wild type genotype of A. nidulans is green due to the coloration of its spores, but this color may vary amongst differing strains. (kenyon.edu)
  • List of A. nidulans strains used in this study. (hindawi.com)
  • DkipB heterozygous strains showed an increased instability of diploid nuclei, which proved once more KipB involvement in mitosis, along with DkipB clear genetic interaction with a mutation in another mitotic kinesin in A. nidulans, bimC4. (uni-marburg.de)
  • All necessary supplements and concentrations for A. nidulans strains can be found at www.fgsc.net . (aspergillus.org.uk)
  • Here, we report the isolation and characterization of Aspergillus nidulans strains carrying conditional ( cfwA2 ) and null (Δ cfwA ) mutant alleles of the cfwA gene, encoding an essential PPTase. (asm.org)
  • Strains of Aspergillus nidulans with chromosome duplications are unstable at mitosis. (newprairiepress.org)
  • In parallel, we produced defined mutant derivatives of mpaC, and the combined analysis of A. nidulans strains expressing mpaC or mutated mpaC genes unequivocally demonstrated that mpaC indeed encodes a polyketide synthase that produces the first intermediate in the production of the medically important immunosuppressant mycophenolic acid. (chalmers.se)
  • The investigation included the A. nidulans wild-type and three mutant strains, two of which were genetically engineered to enhance secondary metabolite production. (cdc.gov)
  • Aspergillus nidulans WT and SirAd strains were cultured in 200 ml of GMM at 30°C for 24, 48, and 72 h, and their total RNA was purified as described above. (omicsdi.org)
  • The hypA orthologues in Saccharomyces cerevisiae and Schizosaccharomyces pombe are essential, whereas hypA deletion strains in Aspergillus nidulans are viable but morphologically abnormal. (usask.ca)
  • Interest in the selection of mutations affecting L-proline catabolism in Aspergillus nidulans is heightened by the involvement of one of the very few examples of a cluster of functionally related genes in an eukaryote and by an increasing awareness of the biological phenomena in which proline and proline catabolism participate. (cambridge.org)
  • In silico analysis of the A. nidulans genome sequence, identified two putative genes designated cnxL and cnxK that might be involved in molybdenum cofactor (a component of nitrate reductase) biosynthesis as well as two putative nitrate reductases encoding genes niaB and niaC. (aspergillus.org.uk)
  • Eisendle, M., Oberegger, H., Zadra, I. and Haas, H. (2003) The Siderophore System Is Essential for Viability of Aspergillus nidulans Functional Analysis of Two Genes Encoding L-Ornithine N5-Monooxygenase (sidA) and a Non-Ribosomal Peptide Synthetase (sidC). (scirp.org)
  • We have validated this system by expressing non-reducing polyketide synthases of Aspergillus terreus and additional genes required for compound production and release. (ku.edu)
  • Isolation and physical characterization of three essential conidiation genes from Aspergillus nidulans. (asm.org)
  • We cloned and characterized three genes from Aspergillus nidulans, designated brlA, abaA, and wetA, whose activities are required to complete different stages of conidiophore development. (asm.org)
  • Molecular cloning and expression in Saccharomyces cerevisiae of two Aspergillus nidulans xylanase genes. (asm.org)
  • The major fungal pathogen of humans, Aspergillus fumigatus , lacks a defined sexual cycle, although the presence of genes encoding putative mating type idiomorphs and regulators of Aspergillus sexual development heightens the potential for cryptic sexuality in this deuteromycete. (asm.org)
  • From genome sequence analyses of the homothallic model ascomycete, A. nidulans , genes encoding α-box and HMG-domain proteins ( matB and matA , respectively) were both found to be present and necessary for sexual reproduction ( 30 ). (asm.org)
  • Here, we evaluate the potential of real-time RT-PCR to quantify the relative transcript levels of ABC transporter Atr genes from Aspergillus nidulans . (asm.org)
  • We also verified the relative transcript levels of the Atr genes in the A. nidulans imazalil-resistant mutants. (asm.org)
  • FacB, the Aspergillus nidulans activator of acetate utilization genes, binds dissimilar DNA sequences. (semanticscholar.org)
  • Here, we summarize current progress towards understanding the function of these genes and the mechanisms involved in polarized hyphal growth and septation in A. nidulans. (nebraska.edu)
  • Several promoter regions of the trpC and crp genes were fused to the npgA gene containing the 1,034-bp open reading frame and the 966-bp 3' downstream region from the TAA, and the constructed fusions were introduced into the NPG mutant in A. nidulans to evaluate color recovery due to the transcriptional activity of the sequence elements. (bvsalud.org)
  • Assigning functions to newly discovered genes constitutes one of the major challenges en route to fully exploiting the data becoming available from the genome sequencing initiatives. (chalmers.se)
  • Aspergillus nidulans possesses threepmt genes encoding protein O-D-mannosyltransferases (Pmt). (elsevier.com)
  • DNA microarray analyses for Aspergillus nidulans FGSCA26 (WT) strain and Gene disruptant of sirA (SirAd) indicated that genes for synthesizing secondary metabolic products such as sterigmatocystin, penicillin G, emericellamide, aspernidine A, xanthone, austinol, and siderophores are down-regulated by SirA. (omicsdi.org)
  • Kraus, PR & Harris, SD 2001, ' The Aspergillus nidulans snt genes are required for the regulation of septum formation and cell cycle checkpoints ', Genetics , vol. 159, no. 2, pp. 557-569. (elsevier.com)
  • Gene comparisons of all three species and cross-analysis with the expression data identified 23 genes to be a conserved response across Aspergillus sp. (pnas.org)
  • An Affymetrix GeneChip was designed for genes from A. nidulans , A. niger , and A. oryzae . (pnas.org)
  • Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans. (nih.gov)
  • Biochemical and antigenic characterization of a new dipeptidyl-peptidase isolated from Aspergillus fumigatus. (springer.com)
  • Molecular characterization of mutants of the acetate regulatory gene facB of Aspergillus nidulans. (semanticscholar.org)
  • Kalman, ET , Varga, J & Kevei, F 1991, ' Characterization of interspecific hybrids within the Aspergillus nidulans group by isoenzyme analysis ', Canadian Journal of Microbiology , vol. 37, no. 5, pp. 391-396. (elsevier.com)
  • Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans. (duke.edu)
  • Herein we present the structural and biochemical characterization of UDP-galactose-4-epimerase from Aspergillus nidulans which produces the precursor UDP-galactopyranose required for galactofuranose synthesis. (duhnnae.com)
  • Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake, miso and soy sauce. (broadinstitute.org)
  • 2016). Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. (springer.com)
  • To test the functionality of these genetic determinants, we transferred the alpha box-encoding mat1-1 idiomorph from an A. fumigatus isolate to the homothallic fertile species Aspergillus nidulans . (asm.org)
  • Moreover, phylogenetic analyses support the occurrence of genetic recombination within the Aspergillus fumigatus population ( 32 ). (asm.org)
  • As deduced from in silico analyses, the genome of the A. fumigatus sequence reference strain Af293 contains many putative gene products that are orthologous to recognized determinants of fruiting body formation in the fertile species Aspergillus nidulans ( 10 , 27 ). (asm.org)
  • The emergence of azole resistance in Aspergillus fumigatus as well as an increasing frequency of multiresistant cryptic Aspergillus spp. (asm.org)
  • We studied the in vivo efficacy of olorofim intraperitoneal therapy (15 mg/kg of body weight every 8 h for 9 days) against infection with A. fumigatus , A. nidulans , and A. tanneri in both neutropenic CD-1 mice and mice with chronic granulomatous disease (CGD) ( gp91 −/− phox mice). (asm.org)
  • The primary etiologic agent of IA in both neutropenic and CGD patient populations is Aspergillus fumigatus ( 5 - 7 ). (asm.org)
  • In addition, IA remains the primary cause of morbidity and mortality in CGD patients and is often due to non- fumigatus Aspergillus spp. (asm.org)
  • Study of the essentiality of the Aspergillus fumigatus triA gene, encoding RNA triphosphatase, using the heterokaryon rescue technique and the conditional gene expression driven by the alcA and niiA promoters. (semanticscholar.org)
  • It has also been shown that growth of an A. fumigatus Δ hxkA Δ glkA strain is reduced on D-glucose and D-fructose [ 8 ] and that the A. nidulans hxkA1 glkA1 mutant is unable to phosphorylate D-glucose and D-fructose [ 5 ]. (biomedcentral.com)
  • Honokiol reduces fungal load and inflammatory cytokines in aspergillus fumigatus keratitis. (greenmedinfo.com)
  • Perillaldehyde ameliorates aspergillus fumigatus keratitis. (greenmedinfo.com)
  • Aspergillus Mix with NDC 22840-9628 is a a non-standardized allergenic label product labeled by Greer Laboratories, Inc.. The generic name of Aspergillus Mix is aspergillus amstelodami, aspergillus flavus, aspergillus fumigatus, aspergillus nidulans and aspergillus niger. (ndclist.com)
  • A. nidulans is a form of filamentous fungi that has been found to serve as a valuable model organism in the realm of eukaryotic cell biology. (kenyon.edu)
  • Members of the genus Aspergillus are the most common fungi and many are beneficial to humans. (genetics.org)
  • There are not many reports on microbial transformation of terpenoids by fungi of the Aspergillus genus, although their ability to transform terpenes is recognised. (aspergillus.org.uk)
  • Filamentous fungi have been widely used in industrial scale production of various compounds and especially Aspergillus niger and Aspergillus nidulans represent potential host organisms for the production and modification of various terpenoid products. (aspergillus.org.uk)
  • In recent decades, pathogenic fungi, such as Aspergillus spp. (asm.org)
  • An Aspergillus nidulans [1] in uska species han Fungi in nahilalakip ha divisio nga Ascomycota , ngan nga syahan ginhulagway ni Eduard Eidam , ngan ginhatag han pagkayana nga asya nga ngaran ni Georg Winter hadton 1884. (wikipedia.org)
  • The genomes of filamentous fungi such as A. nidulans encode a multiplicity of sugar transporters with broad affinities for hexose and pentose sugars. (biomedcentral.com)
  • Amongst these fungi, Aspergillus nidulans has proven to be a particularly valuable model. (nebraska.edu)
  • To develop a convenient promoter analysis system for fungi, a null-pigment mutant (NPG) of Aspergillus nidulans was used with the 4′-phosphopantetheinyl transferase (PPTase) gene, npgA, which restores the normal pigmentation in A. nidulans, as a new reporter gene. (bvsalud.org)
  • The functional organization of serially deleted promoter regions of the A. nidulans trpC gene and the Cryphonectria parasitica crp gene in filamentous fungi was representatively investigated to establish a novel fungal promoter assay system that depends on color complementation of the NPG mutant with the PPTase npgA gene. (bvsalud.org)
  • To facilitate the use of filamentous fungi in functional genomics, we present a versatile cloning system that allows a gene of interest to be expressed from a defined genomic location of Aspergillus nidulans. (chalmers.se)
  • Sterigmatocystin is mainly produced by the fungi Aspergillus nidulans and A. versicolor. (wikipedia.org)
  • The full-genome sequencing of the filamentous fungi Aspergillus nidulans , Aspergillus niger , and Aspergillus oryzae has opened possibilities for studying the cellular physiology of these fungi on a systemic level. (pnas.org)
  • The Aspergillus genus of filamentous fungi has a long history as a work horse in the service of humankind. (pnas.org)
  • Since then, Aspergillus niger has also proven to be a high-yield producer of organic acids and enzymes, and today, both of these fungi are used as hosts for production of heterologous proteins ( 3 ). (pnas.org)
  • Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 degrees C heat exposure. (nih.gov)
  • Meiotic mutants of Aspergillus nidulans: phenotypes, gene localization and gene cloning. (wur.nl)
  • At elevated temperatures, all A. nidulans Δ pmt mutants show cell wall-associated defects and increased sensitivity to cell wall-perturbing agents. (pubmedcentralcanada.ca)
  • The altered developmental patterns in Δ pmt mutants suggest that A. nidulans Pmts modify proteins that serve as spatial cues. (pubmedcentralcanada.ca)
  • NsdD acts positively on early steps of sexual reproduction in A. nidulans without affecting asexual conidiation, as demonstrated by analysis of deletion mutants and overexpression studies ( 16 ). (asm.org)
  • Employing a collection of temperature sensitive nuclear distribution (nudA2, nudC3 and nudF7), nuclear division (nimA5, hfaB3), and septation (sepD5, sepG1) mutants, we have investigated the interdependency among nuclear positioning, mitosis, and cell growth in structuring the cellular compartments of A. nidulans. (biologists.org)
  • Recently, a novel YAP-like bZIP, restorer of secondary metabolism A (RsmA), was found in a suppressor screen of an Aspergillus nidulans secondary metabolism (SM) mutant in which overexpression of rsmA was found to partially remediate loss of SM in Velvet Complex mutants. (microbiologyresearch.org)
  • Here we characterized and contrasted SM in mutants of RsmA and four other A. nidulans bZIP proteins (NapA, ZipA, ZipB and ZipC) with predicted DNA binding motifs similar to RsmA. (microbiologyresearch.org)
  • Previous phenotypic analysis of glucokinase and hexokinase mutants from Aspergillus nidulans demonstrated that at least one of them is required for normal growth on D-fructose or D-glucose. (biomedcentral.com)
  • Aspergillus oryzae (koji mold) was first used for the preparation of food stuffs in China almost 2,000 years ago and was used for one of the first commercial preparations of enzymes in the late 19th century ( 1 , 2 ). (pnas.org)
  • As a parallel to the Yeast 2.0 GeneChip that allows for transcriptome analysis of both Saccharomyces cerevisiae and Schizosaccharomyces pombe , we have designed a chip to facilitate system-wide studies of A. nidulans , A. niger , and A. oryzae . (pnas.org)
  • Even though A. niger and A. oryzae are more closely related to each other than A. nidulans , this lineage is not reflected in the shape and levels of the distributions. (pnas.org)
  • We report that the deletion of sumO, the gene that encodes the small ubiquitin-like protein SUMO in A. nidulans, caused a dramatic increase in the production of the secondary metabolite asperthecin and a decrease in the synthesis of austinol/dehydroaustinol and sterigmatocystin. (nih.gov)
  • We have isolated the Aspergillus nidulans glnA gene encoding GS and have shown that glnA encodes a highly expressed but not highly regulated mRNA. (uniprot.org)
  • However, the A. nidulans fluG gene, which encodes a protein with similarity to prokaryotic GS, did not replace A. nidulans glnA function when similarly expressed. (uniprot.org)
  • Fidel S, Doonan JH, Morris NR (1988) Aspergillus nidulans contains a single actin gene which has unique intron locations and encodes a gamma-actin. (springer.com)
  • The Aspergillus nidulans acuL gene encodes a mitochondrial carrier required for the utilization of carbon sources that are metabolized via the TCA cycle. (semanticscholar.org)
  • The facC gene of Aspergillus nidulans encodes an acetate-inducible carnitine acetyltransferase. (semanticscholar.org)
  • In this study, we identified the A. nidulans xtrD ( x ylose tr ansporter) gene, which encodes a Major Facilitator Superfamily (MFS) transporter, and which was specifically induced at the transcriptional level by xylose in a XlnR-dependent manner, while being partially repressed by glucose in a CreA-dependent manner. (biomedcentral.com)
  • The facB gene of Aspergillus nidulans encodes a DNA binding transcriptional activator required for growth on acetate as a sole carbon source. (edu.au)
  • Selfing in A. nidulans involves activation of the same mating pathways characteristic of sex in outcrossing species, i.e. self-fertilization does not bypass required pathways for outcrossing sex but instead requires activation of these pathways within a single individual. (wikipedia.org)
  • 5] As a model organism, this species' diversified genome (unlike its relatives) allows for a more developed understanding of other species in the Aspergillus genus. (kenyon.edu)
  • A. nidulans was the first Aspergillus species to have its entire genome sequenced, and considering that A. nidulans is sexually reproductive, it contains a well-developed genetics system. (kenyon.edu)
  • Systematics of Aspergillus species of subgenus Nidulantes in Iran - Scientific Figure on ResearchGate. (kenyon.edu)
  • Species in the genus Aspergillus are commonly found in many areas of life on earth, such as in soil, plant debris, water (freshwater or marine), or the air. (kenyon.edu)
  • The use of A. nidulans as a model species allows for the understanding of other Aspergillus species (e.g. (kenyon.edu)
  • A. nidulans is the only species of the Aspergilli that is not asexual. (kenyon.edu)
  • Andersen MR, Vongsangnak W, Panagiotou G, Salazar MP, Lehmann L, Nielsen J (2008) A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species. (springer.com)
  • has been an important research organism for studying eukaryotic cell biology and has a long history of use for the study of a wide range of subjects including basic genetic problems (recombination, DNA repair, mutation), cell cycle control and pathogenesis, as well as metabolism of other Aspergillus species. (sciencephoto.com)
  • Aspergillus species may be homothallic or heterothallic ( 8 ). (asm.org)
  • CGD patients may also suffer from infections due to less common species, such as A. nidulans ( 8 ) and A. tanneri ( 9 ). (asm.org)
  • The results indicate a certain degree of genetic homology among the members of the Aspergillus nidulans species group. (elsevier.com)
  • Sterigmatocystin is a polyketide mycotoxin produced by certain species of Aspergillus. (wikipedia.org)
  • With this case example, we present a validated tool for transcriptome analysis of three Aspergillus species and a methodology for conducting cross-species evolutionary studies within a genus using comparative transcriptomics. (pnas.org)
  • This sort of reproduction is not common within the Aspergillus genus. (kenyon.edu)
  • An Aspergillus nidulans in nahilalakip ha genus nga Aspergillus , ngan familia nga Trichocomaceae . (wikipedia.org)
  • Analysis of Aspergillus nidulans metabolism at the genome-scale. (kenyon.edu)
  • Transcriptome Analysis of Aspergillus nidulans Exposed to Campt" by Iran Malazavi, Marcela Savoldi et al. (unl.edu)
  • Role of carnitine acetyltransferases in acetyl coenzyme A metabolism in Aspergillus nidulans. (semanticscholar.org)
  • Wild-type and mutant stocks of Aspergillus nidulans. (atcc.org)
  • Barratt RW, Johnson GB, Ogata WN (1965) Wild-type and mutant stocks of Aspergillus nidulans . (springer.com)
  • We used immunofluorescent microscopy to characterize microtubule (MT) architecture in wild-type and mutant protoplasts of Aspergillus nidulans at interphase and at mitosis. (rupress.org)
  • Because the visualization of MTs by immunofluorescence is technically difficult in intact hyphae of A. nidulans, we developed a method for removing the cell wall under conditions that do not perturb cell physiology, as evidenced by the fact that the resulting protoplasts undergo nuclear division at a normal rate and that cell cycle mutant phenotypes are expressed at restrictive temperature. (rupress.org)
  • The effects of the inhibitors proflavine and phenylmercuric acetate upon germination of conidia of a mutant of Aspergillus nidulans were investigated. (mun.ca)
  • Investigation of whole genome gene expression level changes in Aspergillus nidulans AN1599 (PbcR) overexpression mutant, compared to the FGSC A4 wild-type strain. (omicsdi.org)
  • The genetics of Aspergillus nidulans. (atcc.org)
  • The original linkage maps were published as illustrations to "The Validity of the Aspergillus nidulans Linkage Map" in Fungal Genetics and Biology 21 , (1997) 267-277, and are reproduced here, with modifications, by permission of Academic Press. (fgsc.net)
  • To assess the function of KipB kinesin in A. nidulans, a kipB disruption strain was constructed. (uni-marburg.de)
  • The catabolism of glucose and xylose was studied in a wild type and creA deleted (carbon catabolite de-repressed) strain of Aspergillus nidulans. (dtu.dk)
  • Here we evaluated if it would be possible to create an Aspergillus nidulans strain that releases, but does not metabolize hexoses from plant biomass. (biomedcentral.com)
  • A haploid strain of the Aspergillus nidulans carried the auxotrophic met-eight mutation conferring a requirement for methionine. (mywordsolution.com)
  • Coloured scanning electron micrograph (SEM) of Aspergillus nidulans hyphae and sexual spores. (sciencephoto.com)
  • The present work analyses the function of a kinesin-like protein in A. nidulans, KipB, which is a member of the Kip3 kinesin family. (uni-marburg.de)
  • E ntry into mitosis in Aspergillus nidulans is regulated by the coordinate function of two serine/threonine protein kinases, NIMX CDC2 and NIMA. (rupress.org)
  • We utilized an expression screen to identify two novel Ca(2+)/calmodulin (CaM)-regulated protein kinases in Aspergillus nidulans. (duke.edu)
  • A recombinant dimeric protein of A. nidulans glutathione reductase (GR) contained FAD and reduced oxidized glutathione (GSSG) using NADPH as an electron donor. (core.ac.uk)
  • FAPP MIXTURE (aspergillus flavus var. (nih.gov)
  • MIXED ASPERGILLUS (aspergillus flavus var. (nih.gov)
  • Finally, the effects of potential nitrate transport inhibitors were studied on net nitrate transport by NrtA and NrtB proteins of A. nidulans. (aspergillus.org.uk)
  • The Δ pmt phenotypes at elevated temperatures, increased sensitivity to cell wall-perturbing agents and restoration to wild-type growth with osmoticum suggest that A. nidulans Pmts modify proteins in the cell wall integrity pathway. (pubmedcentralcanada.ca)
  • Specifically, we identified A. nidulans homologs for yeast proteins involved in (1) filamentation-invasion, (2) cAMP-PKA, (3) pheromone response, (4) cell integrity and (5) TOR signaling pathways. (iospress.com)
  • We note that by using a highly conservative approach, 70% of the S. cerevisiae signal transduction proteins (107 proteins out of 153 proteins studied) have significant homologs in A. nidulans. (iospress.com)
  • Production of the Phanerochaete flavido-alba laccase in Aspergillus niger for synthetic dyes decolorization and biotransformation. (springer.com)
  • Search Results for aspergillus niger var. (nih.gov)
  • A-21 (alternaria alternata, aspergillus niger var. (nih.gov)
  • ASPERSAN (aspergillus niger var. (nih.gov)
  • CANDIDA (ammoniac, aspergillus niger var. (nih.gov)
  • This review covers the attempts being made to trigger the activation of polyketide metabolism in the fungal model organism Aspergillus nidulans . (mdpi.com)
  • The germ tubes of A. nidulans conidia grew exponentially at a rate which was about 2·3 times as great as the specific growth rate of the organism in submerged culture. (microbiologyresearch.org)
  • This study investigated glutathione-dependent mechanisms in the model organism Aspergillus nidulans. (core.ac.uk)
  • Here, we used whole genome DNA microarrays to investigate global transcriptional changes in Aspergillus nidulans gene expression after exposure to hypoxia followed by normoxia. (springer.com)
  • This study is the first to show that hypoxia elicits systematic transcriptional responses in A. nidulans . (springer.com)
  • The major transcriptional repressor for carbon catabolite repression in Aspergillus nidulans is CreA, and mutational analysis led to the suggestion that a regulatory ubiquitination/deubiquitination pathway is involved. (usda.gov)
  • AACD01000000 Aspergillus nidulans FGSC A4, whole genome shotgun sequencing project. (atcc.org)
  • This study characterized the regulation and substrate specificity of an A. nidulans transporter that represents a good candidate for further directed mutagenesis. (biomedcentral.com)
  • In Aspergillus nidulans, germinating conidia undergo multiple rounds of nuclear division before forming a septum. (elsevier.com)
  • NIMA promotes entry into mitosis in late G2 by some mechanism that is after activation of the Aspergillus nidulans G2 cyclin-dependent kinase, NIMX CDC2 /NIME Cyclin B . Here we present two independent lines of evidence which indicate that this mechanism involves control of NIMX CDC2 /NIME Cyclin B localization. (rupress.org)
  • Proposed biosynthesis pathway for asperthecin (4) in A. nidulans . (nih.gov)
  • Our results expand the number of known and predicted secondary metabolites requiring CfwA/NpgA for their biosynthesis and, together with the phylogenetic analysis of fungal PPTases, suggest that a single PPTase is responsible for the activation of all PKSs and NRPSs in A. nidulans . (asm.org)
  • International Space Station conditions alter genomics, proteomics, and metabolomics in Aspergillus nidulans. (cdc.gov)
  • The Aspergillus nidulans acuH gene, required for growth on acetate and long-chain fatty acids, was cloned by complementation of the acuH13 mutation. (semanticscholar.org)
  • Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans. (springer.com)
  • Subsequently, the aim of this study was to identify xylose-transporters from A. nidulans , as potential candidates for introduction into S. cerevisiae in order to improve xylose utilization. (biomedcentral.com)
  • The sequencing of Aspergillus genomes has revealed that the products of a large number of secondary metabolism pathways have not yet been identified. (nih.gov)
  • Homocysteine is an intermediate in methionine synthesis in Aspergillus nidulans , but it can also be converted to cysteine by the reverse transsulfuration pathway involving cystathionine β-synthase (CBS) and cystathionine γ-lyase (CGL). (springer.com)
  • KEGG pathway enrichment of DEGs induced by salt stress in wild-type A. nidulans. (hindawi.com)
  • Activation of the pathway in Aspergillus nidulans lead to a production of ent-pimara-8(14),15-diene. (omicsdi.org)
  • Heterologous expression of the prokaryotic Anabaena glnA gene from the A. nidulans alcA promoter allowed full complementation of the A. nidulans glnADelta mutation. (uniprot.org)
  • In the first run, three biological replicates each of Aspergillus nidulans wild-type RDIT9.32 (veA) and Aspergillus nidulans carrying a plasmid overexpressing rsmA under the control of the gpdA promoter were assayed. (omicsdi.org)
  • For the last 50 years, A. nidulans has been used to study a wide array of processes and topics such as cell cycles, DNA repair, nucleokinesis, pathogenesis, mutation, and evolutionary processes. (kenyon.edu)
  • The sas A-60 (semialdehyde sensitive) mutation in A. nidulans results in toxicity of catabolic precursors of L-glutamic γ-semialdehyde (or its internal Schiff base L-Δ 1 -pyrroline-5-carboxylate) and succinic semialdehyde, apparently without affecting the catabolic pathways concerned. (cambridge.org)
  • The pattern of degeneration suggested That a process similar to the repeat-induced point- mutation (RIP) phenomenon, first described in Neurospora crassa, may have operated in A. nidulans. (forskningsdatabasen.dk)
  • The validity of the Aspergillus nidulans linkage map. (mysciencework.com)
  • The Aspergillus nidulans linkage map is reviewed as a background to physical mapping by cosmid cross-hybridization and genome sequencing. (mysciencework.com)
  • A twelve array study using total RNA recovered from six separate cultures of Aspergillus nidulans wild-type RDIT9.32 (veA) and six separate cultures of Aspergillus nidulans overexpressing rsmA (restorer of secondary metabolism A), using custom-designed, four-plex arrays. (omicsdi.org)
  • Overexpression of the Zn(II)2Cys6 -type transcription factor, AN1599.4 (PbcR, pimaradiene biosynthetic cluster regulator), activates a secondary metabolite gene cluster in Aspergillus nidulans. (omicsdi.org)
  • In the olorofim-treated groups, galactomannan levels were significantly suppressed, with lower organ fungal DNA burdens being seen for all three Aspergillus spp. (asm.org)
  • These results indicated that the fungal glutathione system functions as an antioxidant mechanism in A. nidulans. (core.ac.uk)
  • Schoustra, SE & Punzalan, D 2012, ' Correlation of mycelial growth rate with other characters in evolved genotypes of Aspergillus nidulans ', Fungal Biology , vol. 116, pp. 630-636. (wur.nl)
  • A) Organization of the asperthecin synthase gene cluster in A. nidulans . (nih.gov)
  • There are very few cases of invasive aspergillosis reported in children during induction chemotherapy for acute leukemia and A. nidulans is rare in the absence of chronic granulomatous disease. (ox.ac.uk)
  • We investigated the roles of actin (ActA) and fimbrin (FimA) in hyphal growth in Aspergillus nidulans. (psu.edu)
  • Conidiation in A. nidulans involves many common developmental themes including spatial and temporal regulation of gene expression, specialized cellular differentiation, and intercellular communication. (genetics.org)
  • pH regulation of gene expression in the mold Aspergillus nidulans is one such example. (asm.org)
  • Role of glutamine synthetase in nitrogen metabolite repression in Aspergillus nidulans. (uniprot.org)
  • To access these potentially valuable, cryptic clusters, we have developed a heterologous expression system in Aspergillus nidulans. (ku.edu)
  • Asexual Sporulation in Aspergillus nidulans. (kenyon.edu)
  • The asexual reproductive cycle of A. nidulans begins and ends with the asexual spore called the conidium and can be divided into two distinct phases, growth and development. (genetics.org)
  • These functions were resumed by re-oxygenation, indicating that A. nidulans controls global transcription to adapt to a hypoxic environment. (springer.com)
  • The Aspergillus nidulans zinc finger transcription factor PacC is activated by proteolytic processing in response to ambient alkaline pH. (asm.org)
  • For all eight chromosomes of A. nidulans a reliable framework has been provided by analysis of mitotic crossing over, in many cases substantiated by the study of translocation disomics. (mysciencework.com)
  • The isoenzyme composition of the haploid segregants of the Aspergillus nidulans x Aspergillus rugulosus hybrid differed for some of the enzymes studied from that of the hybrid, suggesting that during segregation further interaction of the chromosomes took place. (elsevier.com)
  • The putative gene encoding acetyl-CoA carboxylase, accA, has been isolated from Aspergillus nidulans. (nih.gov)
  • We used the motor domain of conventional kinesin (KinA) from Aspergillus nidulans to perfom BLAST searches at the public A. nidulans genome database, at the Whitehead Center for Genome Research (Cambridge USA), and identified eleven putative kinesin motors. (uni-marburg.de)
  • SUMMARY: The growth kinetics of Aspergillus nidulans, Mucor hiemalis and Penicillium chrysogenum on solid media and in submerged culture were studied. (microbiologyresearch.org)
  • We have demonstrated the potential of the system by transferring the 7,745-bp large mpaC gene from Penicillium brevicompactum to A. nidulans. (chalmers.se)
  • In this protocol, we describe a rapid and easy method for performing uptake assays in the model filamentous ascomycete Aspergillus nidulans. (aspergillus.org.uk)