A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.
A species of imperfect fungi from which the antibiotic fumigatin is obtained. Its spores may cause respiratory infection in birds and mammals.
A species of imperfect fungi from which the antibiotic nidulin is obtained. Its teleomorph is Emericella nidulans.
An imperfect fungus causing smut or black mold of several fruits, vegetables, etc.
A species of imperfect fungi which grows on peanuts and other plants and produces the carcinogenic substance aflatoxin. It is also used in the production of the antibiotic flavicin.
Infections with fungi of the genus ASPERGILLUS.
Reproductive bodies produced by fungi.
Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.
An imperfect fungus that produces ochratoxins and contaminates EDIBLE GRAIN and coffee beans.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Proteins found in any species of fungus.
Infections of the respiratory tract with fungi of the genus ASPERGILLUS. Infections may result in allergic reaction (ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS), colonization in pulmonary cavities as fungus balls (MYCETOMA), or lead to invasion of the lung parenchyma (INVASIVE PULMONARY ASPERGILLOSIS).
A carcinogenic mycotoxin produced in high yields by strains of the common molds, Aspergillus versicolor, A. nidulans, and an unidentified species of Bipolaris. It causes necrosis of the liver and kidney and has an inhibitory effect on orotic acid incorporation into nuclear RNA.
Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.
Deoxyribonucleic acid that makes up the genetic material of fungi.
An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.
Pulmonary diseases caused by fungal infections, usually through hematogenous spread.
Microscopic threadlike filaments in FUNGI that are filled with a layer of protoplasm. Collectively, the hyphae make up the MYCELIUM.
The functional hereditary units of FUNGI.
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
Lung infections with the invasive forms of ASPERGILLUS, usually after surgery, transplantation, prolonged NEUTROPENIA or treatment with high-doses of CORTICOSTEROIDS. Invasive pulmonary aspergillosis can progress to CHRONIC NECROTIZING PULMONARY ASPERGILLOSIS or hematogenous spread to other organs.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.
A mitosporic Trichocomaceae fungal genus that develops fruiting organs resembling a broom. When identified, teleomorphs include EUPENICILLIUM and TALAROMYCES. Several species (but especially PENICILLIUM CHRYSOGENUM) are sources of the antibiotic penicillin.
Substances of fungal origin that have antigenic activity.
Isocoumarins found in ASPERGILLUS OCHRACEUS and other FUNGI. Ochratoxin contaminated FOOD has been responsible for cases of FOODBORNE DISEASES.
The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.
Toxic compounds produced by FUNGI.
Polysaccharides consisting of mannose units.
Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The study of the structure, growth, function, genetics, and reproduction of fungi, and MYCOSES.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The body of a fungus which is made up of HYPHAE.
Infections of the nervous system caused by fungi of the genus ASPERGILLUS, most commonly ASPERGILLUS FUMIGATUS. Aspergillus infections may occur in immunocompetent hosts, but are more prevalent in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. The organism may spread to the nervous system from focal infections in the lung, mastoid region, sinuses, inner ear, bones, eyes, gastrointestinal tract, and heart. Sinus infections may be locally invasive and enter the intracranial compartment, producing MENINGITIS, FUNGAL; cranial neuropathies; and abscesses in the frontal lobes of the brain. (From Joynt, Clinical Neurology, 1998, Ch 27, pp62-3)
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
A mitosporic Hypocreales fungal genus, various species of which are important parasitic pathogens of plants and a variety of vertebrates. Teleomorphs include GIBBERELLA.
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
The presence of bacteria, viruses, and fungi in the air. This term is not restricted to pathogenic organisms.
Procedures for identifying types and strains of fungi.
A plant species of the family FABACEAE that yields edible seeds, the familiar peanuts, which contain protein, oil and lectins.
A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.
Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.
A systemic agricultural fungicide used for control of certain fungal diseases of stone fruit.
Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.
Reproduction without fusion of two types of cells, mostly found in ALGAE; FUNGI; and PLANTS. Asexual reproduction occurs in several ways, such as budding, fission, or splitting from "parent" cells. Only few groups of ANIMALS reproduce asexually or unisexually (PARTHENOGENESIS).
An enzyme that catalyzes the conversion of myo-inositol hexakisphosphate and water to 1L-myo-inositol 1,2,3,4,5-pentakisphosphate and orthophosphate. EC 3.1.3.26.
Five membered rings containing a NITROGEN atom.
Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The complete gene complement contained in a set of chromosomes in a fungus.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
A cell wall-degrading enzyme found in microorganisms and higher plants. It catalyzes the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. EC 3.2.1.15.
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
A group of enzymes that catalyze the hydrolysis of alpha- or beta-xylosidic linkages. EC 3.2.1.8 catalyzes the endo-hydrolysis of 1,4-beta-D-xylosidic linkages; EC 3.2.1.32 catalyzes the endo-hydrolysis of 1,3-beta-D-xylosidic linkages; EC 3.2.1.37 catalyzes the exo-hydrolysis of 1,4-beta-D-linkages from the non-reducing termini of xylans; and EC 3.2.1.72 catalyzes the exo-hydrolysis of 1,3-beta-D-linkages from the non-reducing termini of xylans. Other xylosidases have been identified that catalyze the hydrolysis of alpha-xylosidic bonds.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A genus of zygomycetous fungi of the family Mucoraceae, order MUCORALES, a common saprophyte and facultative parasite of mature fruits and vegetables. It may cause cerebral mycoses in diabetes and cutaneous infection in severely burned patients.
The ability of fungi to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutations.
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
Glucose polymers consisting of a backbone of beta(1->3)-linked beta-D-glucopyranosyl units with beta(1->6) linked side chains of various lengths. They are a major component of the CELL WALL of organisms and of soluble DIETARY FIBER.
An order of fungi in the phylum ASCOMYCOTA characterized by the presence of well defined peridia and cleistothecial asci. Notable anamorphs (mitosporic forms) of Eurotiales include PENICILLIUM and ASPERGILLUS.
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
A genus of ascomycetous fungi in the family Trichocomaceae, order EUROTIALES. Some species can cause opportunistic infections in humans, similar to its anamorph ASPERGILLUS.
A genus in the family Trichocomaceae, order EUROTIALES. The anamorph is ASPERGILLUS.
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The presence of bacteria, viruses, and fungi in food and food products. This term is not restricted to pathogenic organisms: the presence of various non-pathogenic bacteria and fungi in cheeses and wines, for example, is included in this concept.
Compounds consisting of a short peptide chain conjugated with an acyl chain.
Polysaccharides consisting of xylose units.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The study, utilization, and manipulation of those microorganisms capable of economically producing desirable substances or changes in substances, and the control of undesirable microorganisms.
A disaccharide consisting of two glucose units in an alpha (1-6) glycosidic linkage.
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The intergenic DNA segments that are between the ribosomal RNA genes (internal transcribed spacers) and between the tandemly repeated units of rDNA (external transcribed spacers and nontranscribed spacers).
A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. It is the second most abundant biopolymer on earth, found especially in INSECTS and FUNGI. When deacetylated it is called CHITOSAN.
Sets of enzymatic reactions occurring in organisms and that form biochemicals by making new covalent bonds.
Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists.
Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.
Ribonucleic acid in fungi having regulatory and catalytic roles as well as involvement in protein synthesis.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A mitosporic fungal species used in the production of penicillin.
An exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of GLUCOSE.
A mitosporic Loculoascomycetes fungal genus including some economically important plant parasites. Teleomorphs include Mycosphaerella and Venturia.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
The extent to which an enzyme retains its structural conformation or its activity when subjected to storage, isolation, and purification or various other physical or chemical manipulations, including proteolytic enzymes and heat.
An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, lichenin, and cereal beta-glucans.
A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.
The relationships of groups of organisms as reflected by their genetic makeup.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
The presence in food of harmful, unpalatable, or otherwise objectionable foreign substances, e.g. chemicals, microorganisms or diluents, before, during, or after processing or storage.
OPPORTUNISTIC INFECTIONS with the soil fungus FUSARIUM. Typically the infection is limited to the nail plate (ONYCHOMYCOSIS). The infection can however become systemic especially in an IMMUNOCOMPROMISED HOST (e.g., NEUTROPENIA) and results in cutaneous and subcutaneous lesions, fever, KERATITIS, and pulmonary infections.
A mitosporic fungal genus previously called Monosporium. Teleomorphs include PSEUDALLESCHERIA.
Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.
An enzyme that converts UDP glucosamine into chitin and UDP. EC 2.4.1.16.
Enzymes which catalyze the endohydrolysis of 1,4-beta-D-xylosidic linkages in XYLANS.

Thaumatin production in Aspergillus awamori by use of expression cassettes with strong fungal promoters and high gene dosage. (1/1936)

Four expression cassettes containing strong fungal promoters, a signal sequence for protein translocation, a KEX protease cleavage site, and a synthetic gene (tha) encoding the sweet protein thaumatin II were used to overexpress this protein in Aspergillus awamori lpr66, a PepA protease-deficient strain. The best expression results were obtained with the gdhA promoter of A. awamori or with the gpdA promoter of Aspergillus nidulans. There was good correlation of tha gene dosage, transcript levels, and thaumatin secretion. The thaumatin gene was expressed as a transcript of the expected size in each construction (1.9 or 1.4 kb), and the transcript levels and thaumatin production rate decayed at the end of the growth phase, except in the double transformant TB2b1-44-GD5, in which secretion of thaumatin continued until 96 h. The recombinant thaumatin secreted by a high-production transformant was purified to homogeneity, giving one major component and two minor components. In all cases, cleavage of the fused protein occurred at the KEX recognition sequence. This work provides new expression systems in A. awamori that result in very high levels of thaumatin production.  (+info)

Identification and characterization of genes required for hyphal morphogenesis in the filamentous fungus Aspergillus nidulans. (2/1936)

In the filamentous fungus Aspergillus nidulans, germination of an asexual conidiospore results in the formation of a hyphal cell. A key feature of spore germination is the switch from isotropic spore expansion to polarized apical growth. Here, temperature-sensitive mutations are used to characterize the roles of five genes (sepA, hypA, podB-podD) in the establishment and maintenance of hyphal polarity. Evidence that suggests that the hypA, podB, and sepA genes are required for multiple aspects of hyphal morphogenesis is presented. Notably, podB and sepA are needed for organization of the cytoskeleton at sites of polarized growth. In contrast, podC and podD encode proteins that appear to be specifically required for the establishment of hyphal polarity during spore germination. The role of sepA and the pod genes in controlling the spatial pattern of polarized morphogenesis in germinating spores is also described. Results obtained from these experiments indicate that the normal pattern of germ-tube emergence is dependent upon the integrity of the actin cytoskeleton.  (+info)

Cloning and expression of a cDNA encoding the laccase from Schizophyllum commune. (3/1936)

We cloned and analyzed the nucleotide sequence of a cDNA that encodes polyphenol oxidase (laccase) from the white-rot basidiomycete Schizophyllum commune. The nucleotide sequence of the full-length cDNA contained a 1554-base open reading frame that encoded a polypeptide of 518 amino acid residues, including a putative signal peptide of 16 residues. It contained four highly similar regions that are conserved in the deduced amino acid sequences of other laccases, including the region thought to be involved in copper binding. Aspergillus sojae strain 1860 (which has low protease levels) was transformed with the plasmid lacAL/pTPT, which contained the laccase gene under the control of the tannase promoter from Aspergillus oryzae. Laccase was secreted into the medium when transformants A1 and A2 were cultured in tannic acid-containing medium.  (+info)

Purification and characterization of Aspergillus ficuum endoinulinase. (4/1936)

Endoinulinase from Aspergillus ficuum, which catalyzes the hydrolysis of inulin via an endo-cleavage mode, was purified by chromatography from Novozym 230 as a starting commercial enzyme mixture on CM-Sephadex and DEAE-Sepharose, and by preparative electrophoresis under native conditions. The enzyme was estimated to be pure on the basis of its I/S ratio, whose value was infinite in our assay conditions. Two forms separated by using this method. SDS gel electrophoresis showed the two purified forms to respectively exhibit molecular weights of 64,000 +/- 500 and 66,000 +/- 1,000. The results of deglycosylation indicated that the two forms were originally the same protein but with different sugar contents. A molecular weight of 54,800 +/- 1,500 was found by gel filtration of the native enzyme, indicating the native functional protein to be a monomer. The enzyme showed nearly absolute substrate specificity towards inulin and inulooligosaccharides, and acted via an endo-attack to produce mainly inulotriose during the late stage of the reaction. The apparent Km and Vmax values for inulin hydrolysis were 8.1 +/- 1.0 mM and 773 +/- 60 U/mg, respectively. The internal peptides of the enzyme showed sequence homology to the endoinulinase of Penicillium purpurogenum.  (+info)

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. (5/1936)

In mammals, the Rho family GTPase Rac2 is restricted in expression to hematopoietic cells, where it is coexpressed with Rac1. Rac2-deficient mice were created to define the physiological requirement for two near-identical Rac proteins in hematopoietic cells. rac2-/- neutrophils displayed significant defects in chemotaxis, in shear-dependent L-selectin-mediated capture on the endothelial substrate Glycam-1, and in both F-actin generation and p38 and, unexpectedly, p42/p44 MAP kinase activation induced by chemoattractants. Superoxide production by rac2-/- bone marrow neutrophils was significantly reduced compared to wild type, but it was normal in activated peritoneal exudate neutrophils. These defects were reflected in vivo by baseline neutrophilia, reduced inflammatory peritoneal exudate formation, and increased mortality when challenged with Aspergillus fumigatus. Rac2 is an essential regulator of multiple specialized neutrophil functions.  (+info)

Production of specific monoclonal antibodies to Aspergillus species and their use in immunohistochemical identification of aspergillosis. (6/1936)

Two anti-Aspergillus murine monoclonal antibodies (MAbs), designated 164G and 611F, have been produced; both specifically recognize cytoplasmic antigens of A. fumigatus, A. flavus, and A. niger by enzyme-linked immunosorbent assay. The MAbs can identify Aspergillus spp. both in frozen sections by immunofluorescence and in paraffin-embedded clinical specimens by immunofluorescence and immunoperoxidase staining.  (+info)

Effect of zinc on adenine nucleotide pools in relation to aflatoxin biosynthesis in Aspergillus parasiticus. (7/1936)

The adenylic acid systems of Aspergillus parasiticus were studied in zinc-replete and zinc-deficient media. The adenosine 5'-triphosphate levels of the fungus were high during exponential phase and low during stationary phase in zinc-replete cultures. On the other hand, the levels of adenosine 5'-diphosphate and adenosine 5'-monophosphate were low during exponential phase of growth and high during stationary phase. The adenosine 5'-triphosphate levels during exponential phase may indicate higher primary metabolic activity of the fungus. On the other hand, high adenosine 5'-monophosphate levels during stationary phase may inhibit lipid formation and may enhance aflatoxin levels. The inorganic phosphorus content was low in a zinc-replete medium throughout the growth period, thereby favoring aflatoxin biosynthesis. The energy charge during the exponential phase was high but low during the stationary phase. In general the energy charge values were lower because of high adenosine 5'-monophosphate content.  (+info)

Characterization of the promoter for the gene encoding the aflatoxin biosynthetic pathway regulatory protein AFLR. (8/1936)

Most genes in the aflatoxin biosynthetic pathway in Aspergillus parasiticus are regulated by the binuclear zinc cluster DNA-binding protein AFLR. The aflR promoter was analyzed in beta-glucuronidase reporter assays to elucidate some of the elements involved in the gene's transcription control. Truncation at 118 bp upstream of the translational start site increased promoter activity 5-fold, while truncation at -100 reduced activity about 20-fold. These findings indicate the presence of an important positive regulatory element between -100 and -118 and a negative regulatory region further upstream. Electrophoretic mobility shift assays on nuclear extracts from A. parasiticus induced for aflatoxin expression suggest that AFLR and another, possibly more abundant, protein bind to the -100/-118 region. Another protein binds to a sequence at position -159 to -164 that matches the consensus binding site for the transcription factor involved in pH-dependent gene regulation, PACC.  (+info)

Aspergillus tubingensis XghA protein: pectinolytic enzyme from Aspergillus tubingensis; amino acid sequence in first source; GenBank AJ249460
Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester connected by peptide bonds. These new compounds exhibited pharmacological activity by improving insulin sensitivity, which was evaluated in an adipogenesis model using human bone marrow mesenchymal stem cells. In addition, the compounds exhibited fluorescence changes upon binding to DNA, demonstrating their potential applications to DNA sequence recognition.
Preferred for the invention is CBMs of Carbohydrate-Binding Module Family 20. CBMs of Carbohydrate-Binding Module Family 20 suitable for the invention may be derived from glucoamylases of Aspergillus awamori (SWISSPROT Q12537), Aspergillus kawachii (SWISSPROT P23176), Aspergillus niger (SWISSPROT P04064), Aspergillus oryzae (SWISSPROT P36914), from alpha-amylases of Aspergillus kawachii (EMBL#AB008370), Aspergillus nidulans (NCBI AAF17100.1), from beta-amylases of Bacillus cereus (SWISSPROT P36924), or from CGTases of Bacillus circulans (SWISSPROT P43379). Preferred is a CBM from the alpha-amyiase of Aspergillus kawachii (EMBL:#AB008370) as well as CBMs having at least 50%, 60%, 70%, 80% or even at least 90% homology to the CBM of the alpha-amyiase of Aspergillus kawachii (EMBL#AB008370), i.e. a CBM having at least 50%, 60%, 70%, 80% or even at least 90% homology to the amino acid sequence of SEQ ID NO:6. Also preferred for the invention are the CBMs of Carbohydrate-Binding Module Family 20 ...
Virus infection of Aspergillus foetidus was documented over 40 years ago and was one of the first mycovirus infections described in a filamentous fungus. The virus, named Aspergillus foetidus virus (AfV), contains at least two types of icosahedral particles, called AfV-fast (-F) and AfV-slow (-S) virions, based on their relative electrophoretic mobilities. Here, we report the complete nucleotide sequence of the AfV-F genome isolated from virions purified from the prototype isolate of the fungus. The AfV-F double-stranded (ds) RNA genome is tetra-segmented, and the plus strands of each of the four segments, but not the minus strands, are polyadenylated. The organisation and sequences of the four AfV-F dsRNAs are similar to those described for Alternaria alternata virus 1, which we propose is a member of an emerging mycovirus genus (Alternavirus) and family (Alternaviridae), which also includes AfV-F ...
Proteome IDi ,p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the ,a href=http://www.uniprot.org/manual/proteomes_manual>proteome,/a>. It consists of the characters UP followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.,p>,a href=/help/proteome_id target=_top>More...,/a>,/p> ...
Many diseases of date palm are known. However, pathogens that might affect seed germination and seedling emergence from soil are poorly studied, perhaps because date palm cultivars are propagated vegetatively. Here, we first determined the effects of date seed fungi on the germination and emergence of 600 seeds overall (i.e., 200 of each of three cultivars: ‘Thoory’, ‘Halawi’, and ‘Barhi’). In each cultivar, 100 seeds were from Saudi Arabia (part of the native range), and 100 were from the southwestern USA (where the date palm was introduced around 1765). Just four fungal genera (i.e., Alternaria, Aspergillus, Chaetomium, and Penicillium) were isolated from the surface-sterilized date seeds. Aspergillus isolates all belonged to Aspergillus sect. Nigri; collectively they were in the highest relative abundance at 39%, and significantly more common in Saudi Arabian seeds than in American seeds. Aspergillus reduced seed germination and also reduced emergence when
Habitat, Morphology, Cultural Characteristics, Life Cycle, Pathogenesis, Lab Diagnosis, Treatment and Prevention of Aspergillus clavatus.
A kinetic model to describe lovastatin biosynthesis by Aspergillus terreus ATCC 20542 in a batch culture with the simultaneous use of lactose and glycerol as carbon sources was developed. In order to do this the kinetics of the process was first studied. Then, the model consisting of five ordinary differential equations to balance lactose, glycerol, organic nitrogen, lovastatin and biomass was proposed. A set of batch experiments with a varying lactose to glycerol ratio was used to finally establish the form of this model and find its parameters. The parameters were either directly determined from the experimental data (maximum biomass specific growth rate, yield coefficients) or identified with the use of the optimisation software. In the next step the model was verified with the use of the independent sets of data obtained from the bioreactor cultivations. In the end the parameters of the model were thoroughly discussed with regard to their biological sense. The fit of the model to the ...
Aspergillus terreus ATCC ® 20542D-2™ Designation: Genomic DNA from Aspergillus terreus strain MF4845 (ATCC ® 20542™) Application:
Aspergillus terreus ATCC ® 20542D-2™ Designation: Genomic DNA from Aspergillus terreus strain MF4845 (ATCC ® 20542™) Application:
Reference (original paper): Benzaldehyde derivatives from a marine-​derived fungus Aspergillus sp. Huang, Yuling; Ma, Liying; Rong, Xianguo; Liu, Desheng; Liu, Shaojun; Liu, Weizhong. Zhongcaoyao (2012), 43(5), 837-840. Currently accepted name (anamorph): Aspergillus sp. YT-​008. Computed content type (Species): Species. ...
A detailed and comprehensive genome annotation can be considered a prerequisite for the analysis and interpretation of omics data. GO provides a framework for functional annotation and has been proven to be a valuable tool for omics data analysis, especially in combination with enrichment statistics. Currently, the GO reference genome project [23] provides the most comprehensive manually curated GO annotation for twelve model organisms and is intended to serve as a reference for automated mapping of GO annotation to organisms other than these major models. From the reference genome projects, Saccharomyces cerevisiae and Schizosaccharomyces pombe are most closely related to the genus Aspergillus.. A. nidulans has so far been the only Aspergillus species with comprehensive genome scale GO annotation based on both orthology mapping to S. cerevisiae and extensive manual curation [9] of gene-specific literature. We have thus mapped the A. nidulans GO annotation to all other Aspergillus species (see ...
Non-fumigatus Aspergillus species are the leading cause of Aspergillus infections in the tropical and subtropical regions of the world. In a prospective study between 2015 and 2016, a total of 150 bronchoalveolar (BAL) specimens was collected from patients suspected to pulmonary aspergillosis (PA) underlying immunodeficiencies in Mashhad, Northeastern Iran, located in the Middle East. All Aspergillus strains were phylogenetically identified at the species level by PCR-sequencing of partial β-tubulin gene. Overall, Aspergillus species were isolated from 20 specimens originating from 10 (50%) patients with cancer, 5 (25%) patients receiving corticosteroid therapy, 3 (15%) organ transplant recipients and 2 (10%) patients admitted to intensive care unit (ICU ...
A strain of Aspergillus giganteus cultivated in a medium with xylan produced two xylanases (xylanase I and II) which were… Expand ...
List of fungus species in the genus Aspergillus. The Aspergillus genus includes several hundred fungus species, including: Contents A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Aspergillus acidusAspergillus aculeatinusAspergillus aculeatus Aspergillus aeneusAspergillus affinisAspergillus alabamensisAspergillus alliaceus Aspergillus amazonicusAspergillus ambiguusAspergillus amoenusAspergillus amstelodamiAspergillus amyloliquefaciensAspergillus amylovorusAspergillus anomalusAspergillus anthodesmisAspergillus apicalisAspergillus appendiculatusAspergillus arachidicolaAspergillus arenariusAspergillus arviiAspergillus asperescensAspergillus assulatusAspergillus astellatusAspergillus aurantiobrunneusAspergillus aureofulgensAspergillus aureolatusAspergillus aureoterreusAspergillus aureusAspergillus auricomusAspergillus australensisAspergillus austroafricanusAspergillus avenaceusAspergillus awamori Top A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Aspergillus baarnensisAspergillus ...
Aspergillus comprises a diverse group of species based on morphological, physiological and phylogenetic characters, which significantly impact biotechnology, food production, indoor environments and human health. Aspergillus was traditionally associated with nine teleomorph genera, but phylogenetic data suggest that together with genera such as Polypaecilum, Phialosimplex, Dichotomomyces and Cristaspora, Aspergillus forms a monophyletic clade closely related to Penicillium. Changes in the International Code of Nomenclature for algae, fungi and plants resulted in the move to one name per species, meaning that a decision had to be made whether to keep Aspergillus as one big genus or to split it into several smaller genera. The International Commission of Penicillium and Aspergillus decided to keep Aspergillus instead of using smaller genera. In this paper, we present the arguments for this decision. We introduce new combinations for accepted species presently lacking an Aspergillus name and ...
Orizin (EC 3.4.21.63, Aspergillus alkaline proteinaza, aspergilopeptidaza B, API 21, aspergilopepsin B, aspergilopepsin F, Aspergillus candidus alkalna proteinaza, Aspergillus flavus alkalna proteinaza, Aspergillus melleus semialkalna proteinaza, Aspergillus oryzae alkalna proteinaza, Aspergillus parasiticus alkalna proteinaza, Aspergillus serin proteinaza, Aspergillus sydowi alkalna proteinaza, Aspergillus soya alkalna proteinaza, Aspergillus melleus alkalna proteinaza, Aspergillus sulphureus alkalna proteinaza, prozim, P 5380, kiorinaza, seaproza S, semi-alkalna proteaza, sumizim MP, prozim 10, onoproza, onoproza SA, proteaza P, promelaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju. ...
Aspergillus terreus MTCC 11096 isolated from the soils of agricultural fields cultivating sweet sorghum was previously identified to produce feruloyl esterases (FAEs). The enzymes responsible for feruloyl esterase activity were purified to homogeneity and named as AtFAE-1, AtFAE-2, and AtFAE-3. The …
Citation. Rokas, A., Payne, G., Fedorova, N. D., Baker, S. E., Machida, M., Yu, J., Georgianna, D. R., Dean, R. A., Bhatnagar, D., Cleveland, T. E., Wortman, J. R., Maiti, R., Joardar, V., Amedeo, P., Denning, D. W., Nierman, W. C.. What Can Comparative Genomics Tell Us About Species Concepts In the Genus Aspergillus?. Stud Mycol. 2007 Jan 01; 59: 11-7.. PubMed Citation. Abstract. Understanding the nature of species boundaries is a fundamental question in evolutionary biology. The availability of genomes from several species of the genus Aspergillus allows us for the first time to examine the demarcation of fungal species at the whole-genome level. Here, we examine four case studies, two of which involve intraspecific comparisons, whereas the other two deal with interspecific genomic comparisons between closely related species. These four comparisons reveal significant variation in the nature of species boundaries across Aspergillus. For example, comparisons between A. fumigatus and Neosartorya ...
The transfructosylating activity present in two commercial pectinase preparations (Pectinex Ultra SP-L, from Aspergillus aculeatus, and Rapidase TF, from Aspergillus niger) was studied. Pectinex Ultra SP-L, which has a high transferase/hydrolase ratio, was covalently immobilised on a polymethacrylate-based polymer (Sepabeads® EC) activated with epoxy groups. The influence of pore volume and average pore size on biocatalyst performance was studied for two of these carriers (Sepabeads EC-EP3 and EC-EP5). Several parameters that affect immobilisation such as buffer concentration, pH and amount (mg) of protein added per gram of support (varied over the range 30:1 to 200:1) were analysed. We found that Pectinex Ultra SP-L can be efficiently immobilised on these supports without adding any external salt or buffer. Using Sepabeads EC-EP5 -whose pore volume (1.67 cm3/g) and pore size (800 nm) are higher than those corresponding to Sepabeads EC-EP3- the activity towards sucrose reached 25.9 U/g ...
Neoxaline is a bio-active Aspergillus japonicus isolate. It is an antimitotic agent and shows weak inhibitory activity of blood platelet aggregation induced by simulation of the central nervous system. It has been synthesized through the highly stereoselective introduction of a reverse prenyl group to create a quaternary carbon stereocenter using (−)-3a-hydroxyfuroindoline as a building block, construction of the indoline spiroaminal via cautious stepwise oxidations with cyclizations from the indoline, assembly of (Z)-dehydrohistidine, and photoisomerization of unnatural (Z)-neoxaline to the natural (E)-neoxaline. Satoshi Ōmura Neoxaline an antimiotic agent Hirano, A; Iwai, Y; Masuma, R; Tei, K; Omura, S (1979). Neoxaline, a new alkaloid produced by Aspergillus japonicus. Production, isolation and properties. J Antibiot (Tokyo). 32 (8): 781-785. doi:10.7164/antibiotics.32.781. PMID 500498. Ideguchi, Tetsuya; Yamada, Takeshi (August 11, 2013). Asymmetric Total Synthesis of Neoxaline. The ...
This paper reports the contamination of ready-to-use food thickeners, collected from the South-East geo-political zone in Nigeria, by aflatoxigenic form of Aspergillus species. A total of 150 samples from different open markets were observed for fungal contamination by using serial dilution-spread plate method. Although, Aspergillus, Fusarium and Penicillium were the most frequently isolated fungi, Aspergillus species were found to be the most prevalent in all the samples. Furthermore, Aspergillus flavus and Aspergillus parasiticus produced aflatoxin on yeast extract sucrose (YES) media incubated for 10 to 15 days at 27°C in a CO2 incubator. Aspergillus niger showed no sign of any secondary metabolite on the media, set at similar conditions. Although, light microscopy was used to identify these fungi, based on colony morphology, PCR method was used to confirm genetic variation among the Aspergillus group, using ITS set
This study reports differential expression of endoglucanase (EG) and beta-glucosidase (betaG) isoforms of Aspergillus terreus. Expression of multiple isoforms was observed, in presence of different carbon sources and culture conditions, by activity staining of poly acrylamide gel electrophoresis gels. Maximal expression of four EG isoforms was observed in presence of rice straw (28 U/g DW substrate) and corn cobs (1.147 U/ml) under solid substrate and shake flask culture, respectively. Furthermore, the sequential induction of EG isoforms was found to be associated with the presence of distinct metabolites (monosaccharides/oligosaccharides) i.e., xylose (X), G(1), G(3) and G(4) as well as putative positional isomers (G(1)/G(2), G(2)/G(3)) in the culture extracts sampled at different time intervals, indicating specific role of these metabolites in the sequential expression of multiple EGs. Addition of fructose and cellobiose to corn cobs containing medium during shake flask culture resulted in up
Gogoi, R.; Roy, A.K., 1993: Effect of foliar spraying of Aspergillus terreus Thom on sheath blight (ShB) and rice plant characteristics
The patient stayed 12 days at the hospital, and was submitted to several radiological and laboratory tests. Computerized axial tomography and resonance magnetic imaging were normal. The enzyme-linked immunosorbent assay (ELISA) for HIV 1 and 2 was repeatedly negative. Other two samples of CSF were collected and cultures to bacteria and fungi were negative, slide latex agglutination (SLA) tests to cryptococcal antigen, Haemophilus influenza, Neisseria meningitidis, Streptococcus pneumoniae were negative. The patient was followed on consultations and five CSF examinations were done during a follow up period of a month, when the diagnosis was finally established. In the first CSF sample, a polymerase chain reaction (PCR) to Mycobacterium tuberculosis was negative. In the next CSF sample, culture to fungi was positive to Aspergillus sp and the immunodiffusion test showed presence of antibodies against Aspergillus sp. Other immunological tests to Histoplasma, Cysticercus and Sporothrix were negative. ...
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003 ...
Next-day shipping cDNA ORF clones derived from ACLA_013420 Cytochrome P450 oxidoreductase, putative available at GenScript, starting from $99.00.
Soil-dwelling fungal species possess the versatile metabolic capability to degrade complex organic compounds that are toxic to humans, yet the mechanisms they employ remain largely unknown. Benzo[a]pyrene (BaP) is a pervasive carcinogenic contaminant, posing a significant concern for human health. Here, we report that several Aspergillus species are capable of degrading BaP. Exposing Aspergillus nidulans cells to BaP results in transcriptomic and metabolic changes associated with cellular growth and energy generation, implying that the fungus utilizes BaP as a growth substrate. Importantly, we identify and characterize the conserved bapA gene encoding a cytochrome P450 monooxygenase that is necessary for the metabolic utilization of BaP in Aspergillus. We further demonstrate that the fungal NF-kappa B-type velvet regulators VeA and VelB are required for proper expression of bapA in response to nutrient limitation and BaP degradation in A. nidulans. Our study illuminates fundamental knowledge of ...
Balajee, SA, Marr, KA. Phenotypic and genotypic identification of human pathogenic aspergilli. Future Microbiol. vol. 1. 2006. pp. 435-45. Camps, SM, Rijs, AJ, Klaassen, CH. Molecular epidemiology of isolates harboring the TR34/L98H azole resistance mechanism. J Clin Microbiol. vol. 50. 2012. pp. 2674-80. Cornely, OA, Maertens, J, Bresnik, M. Liposomal amphotericin B as initial therapy for invasive mold infection: a randomized trial comparing a high-loading dose regimen with standard dosing (AmBiLoad trial). Clin Infect Dis. vol. 44. 2007. pp. 1289-97. Cornely, OA, Maertens, J, Winston, DJ. Posaconazole vs fluconazole or itraconazole prophylaxis in patients with neutropenia. N Eng J Med. vol. 356. 2007. pp. 348-59. DHaese, J, Theunissen, K, Vermeulen, E. Detection of galactomannan in bronchoalveolar lavage fluid samples of patients at risk for invasive pulmonary aspergillosis: analytical and clinical validity. J Clin Microbiol. vol. 50. 2012. pp. 1258-63. Herbrecht, R, Denning, DW, ...
Metabolic products of Aspergillus terreus. VI. Metabolites of the strain IFO 8835. (3)​. The isolation and chemical structures of colorless metabolites. Arai, Kunizo; Shimizu, Sakae; Yamamoto, Yuzuru. Chemical & Pharmaceutical Bulletin (1981), 29(4), 1005-12 Metabolic products of Aspergillus terreus. X. Biosynthesis of asterriquinones. Arai, Kunizo; Yamamoto, Yuzuru. Chemical & Pharmaceutical Bulletin (1990), 38(11), 2929-32 ...
Background: The diagnosis of invasive asperigllosis (IA) is limited by poor sensitivity and specificity of microbiologic cultures, and the inability of conventional histopathologic tests to distinguish IA from invasive fungal infections (IFI) caused by non-Aspergillus moulds. Aspergillus-specific immunohistochemistry (IHC) and in situ hybridization (ISH) could facilitate direct diagnosis of IA within tissue. Methods: IHC and ISH were performed on deparaffinized, formalin-fixed sections from previously diagnosed cases of proven IFI, and slides interpreted by pathologist blinded to diagnosis. IHC: Primary Aspergillus antibody (Abcam, MA) and secondary anti-rabbit antibody were detected with Avidin Biotin Complex and visualized using liquid DAB. ISH: Commercially synthesized Locked Nucleic Acid probe for Aspergillus was detected using antiflourescein AP. Poly T stained tissue section was used to determine the area of tissue to be studied. Results: 8 tissue sections were available from patients with ...
TY - JOUR. T1 - Hydrophobins from Aspergillus species cannot be clearly divided into two classes. AU - Jensen,Britt Guillaume. AU - Andersen,Mikael Rørdam. AU - Pedersen,Mona Højgaard. AU - Frisvad,Jens Christian. AU - Søndergaard,Ib. PY - 2010. Y1 - 2010. N2 - Background Hydrophobins are a family of small secreted proteins with a characteristic pattern of eight cysteine residues found exclusively in filamentous fungi. They have originally been divided into two classes based on their physical properties and hydropathy patterns, and are involved in the attachment of hyphae to hydrophobic structures, the formation of aerial structures and appear to be involved in pathogenicity. Findings Analysis of nine genome sequences from seven Aspergilli revealed fifty hydrophobins, where each species displayed between two to eight hydrophobins. Twenty of the identified hydrophobins have not previously been described from these species. Apart from the cysteines, very little amino acid sequence homology was ...
Esta tesis se compone de dos articulos: 1. Profilaxis con anfotericina B nebulizada contra la infección por Aspergillus en el trasplante de pulmón: Estudio de factores de riesgo. J Heart Lung Transplant 2001;20: 1274-1281. Introducción: La infección por Aspergillus spp. permanece como una causa importante de morbilidad y mortalidad en el trasplante de pulmón (TP). Algunas estrategias de profilaxis han sido ensayadas. Una de ellas es la anfotericina B nebulizada (nAB). Sin embargo, la eficacia de esta profilaxis no ha sido claramente demostradas. El objetivo de este estudio fue determinar si la profilaxis con nAB puede proteger contra la infección por Aspergillus spp. en los receptores de TP. Pacientes y métodos: Un estudio de factores de riesgo fue realizado en 55 pacientes con TP. 22 potenciales factores de riesgo fueron analizados. En 44 (80%) de los pacientes la nAB fue indicada como profilaxis. Se realizó un estudio multivariante utilizando regresión logística. Resultados: Dieciocho de 55
Despite the fact that PCR for the detection of Aspergillus in human specimens exists for almost two decades, the technique was not included in the European Organisation for Research and Treatment of Cancer and the Mycoses Study Group (EORTC/MSG) consensus definitions for diagnosing invasive fungal diseases (IFD) because of the lack of standardisation. In 2006, the UK Fungal PCR Consensus group published an agreed methodology for PCR aided diagnosis of IA within the UK and Ireland. Then, at the meeting of the International Society for Human and Animal Mycoses (ISHAM) in Paris in September 2006, a group of mainly European experts founded the European Aspergillus PCR Initiative (EAPCRI) involving more than 60 centres across Europe and centres in Australia and the Middle East.. The EAPCRI agreed to collaborate to develop a standard for Aspergillus PCR methodology and to validate this in clinical trials so that PCR could be incorporated into future consensus definitions for diagnosing IFD.. The ...
A panel of human serum samples spiked with various amounts of Aspergillus fumigatus genomic DNA was distributed to 23 centers within the European Aspergillus PCR Initiative to determine analytical performance of PCR. Information regarding specific methodological components and PCR performance was requested. The information provided was made anonymous, and meta-regression analysis was performed to determine any procedural factors that significantly altered PCR performance. Ninety-seven percent of protocols were able to detect a threshold of 10 genomes/ml on at least one occasion, with 83% of protocols reproducibly detecting this concentration. Sensitivity and specificity were 86.1% and 93.6%, respectively. Positive associations between sensitivity and the use of larger sample volumes, an internal control PCR, and PCR targeting the internal transcribed spacer (ITS) region were shown. Negative associations between sensitivity and the use of larger elution volumes (>/=100 mul) and PCR targeting ...
A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in cholesterol biosynthesis.
Axel Brakhage. Director of the Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute (HKI). and. Professor and Chair of Microbiology / Molecular Biology. Friedrich-Schiller-University Jena. Department Molecular and Applied Microbiology. Research. Pathogenicity of Aspergillus fumigatus and secondary metabolism of Aspergillus nidulans. ...
Background Microsatellites (or short tandem repeats, STRs) are the genetic markers of choice for studying Aspergillus fumigatus molecular epidemiology due to its reproducibility and high discrimination power. However, the specificity of these markers must ...
Misdiagnosis of Malt Workers disease - Aspergillus spp. including hidden diseases, diagnosis mistakes, alternative diagnoses, differential diagnoses, and misdiagnosis.
Aspergillus spp. answers are found in the Johns Hopkins HIV Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
The University of Minnesota is one of the most comprehensive public universities in the United States and ranks among the most prestigious. It is both the state land-grant university, with a strong tradition of education and public service, and the states primary research university, with faculty of national and international reputation.
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Scanning electron micrograph of |I|Aspergillus|/I| producing spores, computer-coloured green. The picture shows an |I|Aspergillus|/I| conidiophore with conidia (spores) budding off (tissues stained blue). |I|Aspergillus|/I| is a genus of ascomycetes, some species of which cause aspergillosus or severe asthmatic reactions in humans; other species have industrial uses, e.g. in the processing of soybeans and the fermentation of sake.
Dr Caroline Baxter reported highly sensitive performance of MycAssay™ Aspergillus in CF sputum which is 260% more sensitive than the currently used culture.
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Die Universität zu Köln ist eine Exzellenzuniversität mit dem klassischen Fächerspektrum einer Volluniversität. Als eine der größen Hochschulen Europas arbeitet sie in Forschung und Lehre auch international auf höchstem Niveau.
The University of Minnesota is one of the most comprehensive public universities in the United States and ranks among the most prestigious. It is both the state land-grant university, with a strong tradition of education and public service, and the states primary research university, with faculty of national and international reputation.
Looking for online definition of Aspergillus clavatus in the Medical Dictionary? Aspergillus clavatus explanation free. What is Aspergillus clavatus? Meaning of Aspergillus clavatus medical term. What does Aspergillus clavatus mean?
TY - JOUR. T1 - Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. AU - Szigeti, Gyöngyi. AU - Sedaghati, Ebrahim. AU - Mahmoudabadi, Ali Zarei. AU - Naseri, Ali. AU - Kocsubé, S.. AU - Vágvölgyi, C.. AU - Varga, J.. PY - 2012/7. Y1 - 2012/7. N2 - Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited ...
TY - JOUR. T1 - Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis. AU - Viscoli, Claudio. AU - Machetti, Marco. AU - Gazzola, Paola. AU - De Maria, Andrea. AU - Paola, Dimitri. AU - Van Lint, Maria Teresa. AU - Gualandi, Francesca. AU - Truini, Mauro. AU - Bacigalupo, Andrea. PY - 2002. Y1 - 2002. N2 - The Aspergillus galactomannan test was performed on cerebrospinal fluid and serum samples from 5 patients with probable cerebral aspergillosis and from 16 control patients. Cerebrospinal fluid galactomannan levels were significantly higher in aspergillosis patients, and most galactomannan was produced intrathecally. Comparison of serum galactomannan values in pulmonary and cerebral aspergillosis patients showed significant overlapping. Detection of Aspergillus galactomannan in cerebrospinal fluid may be diagnostic of cerebral aspergillosis.. AB - The Aspergillus galactomannan test was performed on cerebrospinal ...
TY - JOUR. T1 - Fungal endophthalmitis caused by Aspergillus ustus in a patient following cataract surgery. AU - Taner Yildiran, Sinasi. AU - Mehmet Mutlu, Fatih. AU - Ali Saracli, Mehmet. AU - Uysal, Yusuf. AU - Gonlum, Ahmet. AU - Sobaci, Gungor. AU - Sutton, Deanna A.. PY - 2006/11. Y1 - 2006/11. N2 - The first case of postoperative endophthalmitis after cataract surgery caused by Aspergillus ustus, a species that has only rarely been implicated in human disease, is described. Six weeks after cataract surgery, a 67-year-old medically controlled diabetic patient presented with uveitis, mild ciliary injection and ocular discomfort. Anterior chamber paracentesis, vitreous tap and finally complete vitrectomy with removal of the capsular bag including the intraocular lens were performed and several sets of culture yielded A. ustus. Despite vigorous systemic (itraconazole and caspofungin) and intravitreal (amphotericin B and caspofungin) antifungal therapy, the endophthalmitis did not improve. The ...
LOINC Code 51529-6 Mold Allergen Mix 4 (Aspergillus fumigatus+Aspergillus niger+Aspergillus terreus+Aspergillus flavus) IgE Ab [Presence] in Serum by Multidisk
Nesta tese foram feitos estudos mais aprofundados de enzimas produzidas pelo fungo Aspergillus tamarii em diferentes contextos de degradação de biomassa lignocelulósica. O primeiro trabalho avaliou a influência de condições de cultivo na ação de celulases e xilanases e demonstrou que ferramentas estatísticas (CCD e CCRD) são necessárias para avaliar o comportamento da enzima em diferentes condições. Os resultados demonstraram que utilização de triptona como fonte de nitrogênio inibiu fortemente a atividade das celulases, enquanto aumentou das xilanases. Além disso, a suplementação com CuSO4 aumentou a atividade de todas as enzimas. Sugere-se que influência dos componentens do meio de culturam devem ser considerados ao fazer um planjamento de coquetel enzimático de fungo. O segundo trabalho avaliou os parâmetros termodinâmicos de uma xilanase pura de baixa massa molecular (22 kDa) de A. tamarii ativa em ácido ferúlico. Após análise de molecular docking de uma xilanase ...
Orange peel is an agroindustrial waste rich in pectin and known to be an inducer for pectinase production. The use of this low-cost substrate for the production of an industrially important enzyme, polygalacturonase (PG), can be an alternative way to turn this waste into a value-added product, contributing to the reduction of environmental waste disposal problems. Enzyme productions by fungal microorganisms are affected by environmental and nutritional factors, demanding the determination of optimum conditions for maximum enzyme production with the desired fungal morphology and broth rheology. Therefore, complex and additional carbon sources were optimized with respect to PG production by Aspergillus sojae using statistical approaches. Effect of pH, another significant parameter affecting the rheology and morphology of the strain, was investigated in the serial bioreactor system using the optimized medium composition. Highest PG enzyme yield and productivity together with the maximum PG enzyme ...
Phytase is a phosphatase enzyme widely used as feed additive to release inorganic phosphorus from plant phytate and enhance its uptake in monogastric animals. Although engineered fungal phytases are used most, a natural enzyme gives opportunity to understand novel properties, if any. In the current study, a novel fungal strain, Aspergillus foetidus MTCC 11682 was immobilized on poly urethane cubes and used for phytase production, purification and molecular characterization. Phytase produced by this method was partially purified by ammonium sulphate precipitation and Sephacryl S-200HR gel filtration to 23.4-fold (compared to crude extract) with recovery of 13% protein. Electrophoresis analysis revealed that phytase has molecular weight of 90.5 kDa on non-reducing and 129.6 kDa on reducing SDS-PAGE. The purified phytase exhibited a wider pH and temperature stability. Analysis of the cloned sequence showed that the gene has 1176 bp that encodes for a peptide of 391 amino acids of the core catalytic region.
Fatty acid desaturases play a key role in producing polyunsaturated fatty acids by converting single bonds to double bonds. In the present study, a total of 13, 12, 8 and 8 candidate fatty acid desaturases genes were identified in the Aspergillus oryzae, Aspergillus flavus, Aspergillus fumigatus and Aspergillus nidulans genomes through database searches, which were classified into five different subfamilies based on phylogenetic analysis. Furthermore, a comprehensive analysis was performed to characterize conserved motifs and gene structures, which could provide an intuitive comprehension to learn the relationship between structure and functions of the fatty acid desaturases genes in different Aspergillus species. In addition, the expression pattern of 13 fatty acid desaturases genes of A. oryzae was tested in different growth stages and under salt stress treatment. The results revealed that the fatty acid desaturases genes in A. oryzae were highly expressed in adaptive phase growth and up-regulated
Declining oil reserves, political instability, climate change concerns and rising CO2 emissions have led to new interest in biofuels to supplement the growing demand for alternative and sustainable sources of transport fuels. Biofuels, which includes bio-ethanol, can be produced from renewable biomass resources that include dedicated crops (e.g. corn), by-products from agricultural processing activities (e.g. sugarcane bagasse) or even organic municipal waste. Although the positive environmental impact and sustainable nature of biofuels render it advantageous over fossil fuels [1], the cost-effective production of biofuels remains a challenge.. Starch, one of the most abundant polysaccharides in nature, has been used for commercial bio-ethanol production for a number of years, with a relatively mature technology developed for corn in the USA [2, 3]. The USA produced 52.6 billion litres of ethanol fuel in 2011, an increase from 49.2 billion litres in 2010 [4]. However, the limitations of current ...
Scanning electron micrograph (SEM) of Green mould (Aspergillus flavus) - conidiophore (fruiting structure) producing conidia (asexual conidia). Aspergillus flavus is a wide spread saprophyte found in soil, seeds, fruits and decaying vegetation. It is also found indoors on water damaged carpets and building materials. It is one of the Aspergillus species which causes aspergillosis, commonly in the tropics. Aspergillosis is a respiratory lung infection in people with weakened lungs or that are immune deficient (especially AIDS patients). This fungus produces aflatoxin, a group of virulent mycotoxins that are known animal carcinogens. These mycotoxins are can induce liver cancer in humans. The toxins may contaminate stored food (particularly carbohydrates). A. flavus has also been reported to be allergenic and its presence is associated with asthma. Magnification: x220 when shortest axis printed at 25 millimetres. - Stock Image C037/0238
Pectolyase Y-23 is a highly purified maceration enzyme from Aspergillus japonicus. It contains two types of pectinase such as endopolygalacturonase and endo-pectin lyase in high activity. Included is a maceration stimulating factor which stimulates tissue maceration by both pectinases. Pectolyase Y-23 is a highly purified maceration enzyme from Aspergillus japonicus. It contains two types of pectinase such as endopolygalacturonase and endo-pectin lyase in high activity. Included is a maceration stimulating factor which stimulates tissue maceration by both pectinases. Unit Definition: One unit is defined as an increase in A235 by 1.0 in the reaction mixture per minute.. ...
ASPBA : The Platelia Aspergillus enzyme immunoassay (EIA) is a 1-stage immunoenzymatic sandwich microplate assay that detects galactomannan in bronchoalveolar lavage (BAL) specimens. The assay uses the rat monoclonal antibody EBA-2, which is directed against Aspergillus galactomannan. The monoclonal antibody is used 1) to coat the wells of the microplate and bind the antigen and 2) as the detector antibody in the conjugate reagent (peroxidase-linked monoclonal antibody).   Samples are heat-treated in the presence of EDTA in order to dissociate immune complexes and to precipitate proteins that could possibly interfere with the test. The treated samples and conjugate are added to the wells coated with the monoclonal antibody and incubated. A monoclonal antibody-galactomannan-monoclonal antibody/peroxidase complex is formed in the presence of Aspergillus antigen.   The strips are washed to remove any unbound material, and the substrate solution is added, which will react with the
Light-induced delayed luminescence (DL) of living organisms contains information on the quality of the living state of these organisms. Employing a LS-55 Luminescence Spectrometer, the changes of DL spectra of rice with Aspergillus flavus treating different time were observed. Rice with Aspergillus flavus treatment for a shorter time had a stronger intensity of DL. The polluted degree of Aspergillus showed a negative correlation with the intensity of DL. Comparing with the intensity of DL, we found that the concentration of aflatoxin in different polluted degree rice had negative correlation with the intensity of DL. We believe DL technique may be helpful in elaborating a fast, holistic, and non-invasive method for the rapid evaluation the polluted degree of rice by Aspergillus flavus.. © 2005 Chinese Optics Letters. PDF Article ...
A novel hemicellulase-producing fungal strain was isolated from a local soil sample. The organism is identified as Aspergillus fumigatus based on ribosomal RNA analyses. The Aspergillus strain, designated as 2NB, produces both enzymes acting on xylan backbone (xylanase and β-xylosidase), and those acting on side chains (or accessory enzymes) notably α-arabinofuranosidase and acetyl-xylan esterase. The Asperigillus hemicellulases are characterized as having relatively low xylanase and β-xylosidase activities but high side chain removal activities. The activity ratio of side-chain acting enzymes to xylanase is higher than that of the Multifect enzyme, a commercial hemicellulase product. The potential of the novel hemicellulases in lignocelluloses bioprocessing was demonstrated with alkaline-pretreated switchgrass as lignocellulose substrate with hemicellulase supplemented with a ratio of xylanase activity to filter paper unit of 2:1. Supplement of Aspergillus hemicellulases to commercial ...
Order Aspergillus clavatus Phosphatidylinositol transfer protein sfh5 sfh5 -Mammalian Cell 01022755170 at Gentaur Aspergillus clavatus Phosphatidylinositol transfer protein sfh5 (sfh5) Mammalian
1 Adams, T. H., Wieser, J. K., & Yu, J.-H. (1998). Asexual Sporulation in Aspergillus nidulans. Microbiology and Molecular Biology Reviews, 62(2), 545-545. doi: 10.1128/mmbr.62.2.545-545.1998 https://mmbr.asm.org/content/62/1/35.full 2 David, H., Özçelik, I. Ş., Hofmann, G., & Nielsen, J. (2008). Analysis of Aspergillus nidulans metabolism at the genome-scale. BMC Genomics, 9(1), 163. doi: 10.1186/1471-2164-9-163 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386489/ 3 Galagan JE; et al. (2005). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature. 438 (7071): 1105-15. doi:10.1038/nature04341. PMID 16372000. https://www.ncbi.nlm.nih.gov/pubmed/16372000 4 Gugnani, H. C. (2003). Ecology and taxonomy of pathogenic aspergilli. Frontiers in Bioscience, 8(6). doi: 10.2741/1002 ...
1 Adams, T. H., Wieser, J. K., & Yu, J.-H. (1998). Asexual Sporulation in Aspergillus nidulans. Microbiology and Molecular Biology Reviews, 62(2), 545-545. doi: 10.1128/mmbr.62.2.545-545.1998 https://mmbr.asm.org/content/62/1/35.full 2 David, H., Özçelik, I. Ş., Hofmann, G., & Nielsen, J. (2008). Analysis of Aspergillus nidulans metabolism at the genome-scale. BMC Genomics, 9(1), 163. doi: 10.1186/1471-2164-9-163 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386489/ 3 Galagan JE; et al. (2005). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature. 438 (7071): 1105-15. doi:10.1038/nature04341. PMID 16372000. https://www.ncbi.nlm.nih.gov/pubmed/16372000 4 Gugnani, H. C. (2003). Ecology and taxonomy of pathogenic aspergilli. Frontiers in Bioscience, 8(6). doi: 10.2741/1002 ...
ID G7XC55_ASPKW Unreviewed; 497 AA. AC G7XC55; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 22-NOV-2017, entry version 26. DE SubName: Full=Aspartyl aminopeptidase {ECO:0000313,EMBL:GAA84418.1}; GN ORFNames=AKAW_02533 {ECO:0000313,EMBL:GAA84418.1}; OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus OS awamori var. kawachi). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus. OX NCBI_TaxID=1033177 {ECO:0000313,EMBL:GAA84418.1, ECO:0000313,Proteomes:UP000006812}; RN [1] {ECO:0000313,EMBL:GAA84418.1, ECO:0000313,Proteomes:UP000006812} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NBRC 4308 {ECO:0000313,Proteomes:UP000006812}; RX PubMed=22045919; DOI=10.1128/EC.05224-11; RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., RA Takashita H., Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.; RT Genome sequence of the white ...
Lung transplant recipients have the highest rate of Invasive Aspergillus (IA)infection among solid organ transplant recipients. The most important risk factor for the development of IA (which is associated with disease and death) is colonization of the organism in the respiratory tract.. Azoles are used to prevent the development of IA. Puffers containing antifungal medication can be used to treat the lungs without the need to worry about the medication interactions & side-effects in the blood. An example of this is the aerosolized amphotericin B. Its use is limited by the patients tolerating this medication that may cause cough, nausea & contraction of the air pathways.. The lipid preparation is better tolerated and has longer dosing interval than inhaled amphotericin B. The investigators propose a pilot study to determine the long-term safety of inhaled AmBisome administration of drug and generate the preliminary data on the effectiveness of this drug to prevent aspergillus colonization. ...
Aflatoxins are a potent carcinogenic mycotoxin and has become a research model of fungal secondary metabolism (SM). Via systematically investigating the APSES transcription factors (TFs), two APSES proteins were identified: AfRafA and AfStuA. These play central roles in the synthesis of mycotoxins including aflatoxin and cyclopiazonic acid, and fungal development and are consequently central to the pathogenicity of the aflatoxigenic A. flavus. Loss of AfRafA not only dramatically suppressed aflatoxin cluster expression, subsequently reducing toxin synthesis both in vitro and in vivo, but also impaired conidia and sclerotia development. More importantly, aflatoxin biosynthesis as well as conidia and sclerotia development were fully blocked in ΔAfStuA. In addition, our results supported that AfStuA regulated the aflatoxin synthesis in an AflR-dependent manner. Intriguingly, it was revealed that AfRafA and AfStuA exert an antagonistic role in the regulation of biosynthesis of cyclopiazonic acid. In
TWENTY FIVE Aspergillus isolates were screened from Giza Governorate and Saint Catherine Protectorate soils in Egypt. The antimicrobial activity of the crude extracts was tested against two Gram positive bacteria (Bacillus subtilis NRRL-B-4219, Staphylococcus aureus ATCC29213), four Gram negative bacteria (Alcaligenes faecalis B-170, Escherichia coli ATCC25922, Klebsiella pneumoniae ATCC10131, Pseudomonas aeruginosa ATCC27953), and one yeast (Candida albicans ATCC10231). The antioxidant activity using free radical scavenging model was assayed for the crude extracts. The antitumor activity for all of crude extracts was determined against HCT116 (Colon carcinoma cell line), HEPG2 (Liver carcinoma cell line), and MCF-7 (Breast carcinoma cell line). Aspergillus nomius was the most potent fungal species accordingly, it was chosen for bioactivity assay. Identification of this species was further confirmed at the molecular level based on nuclear ribosomal DNA 18s identities. An accession number, LC199488, was
The refined crystal structures of a proteolytic fragment of glucoamylase from Aspergillus awamori var. X100 have been determined at pH 6 and 4 to a resolution of 2.2 A and 2.4 A, respectively. The models include the equivalent of residues 1 to 471 of glucoamylase from Aspergillus niger and a complete interpretation of the solvent structure. The R-factors of the pH 6 and 4 structures are 0.14 and 0.12, respectively, with root-mean-square deviations of 0.014 A and 0.012 A from expected bondlengths. The enzyme has the general shape of a doughnut. The hole of the doughnut consists of a barrier of hydrophobic residues at the center, which separates two water-filled voids, one of which serves as the active site. Three clusters of water molecules extend laterally from the active site. One of the lateral clusters connects the deepest recess of the active site to the surface of the enzyme. The most significant difference in the pH 4 and 6 structures is the thermal parameter of water 500, the putative ...
TY - JOUR. T1 - Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. AU - Nuetzmann, Hans-Wilhelm. AU - Reyes-Dominguez, Yazmid. AU - Scherlach, Kirstin. AU - Schroeckh, Volker. AU - Horn, Fabian. AU - Gacek, Agnieszka. AU - Schümann, Julia. AU - Hertweck, Christian. AU - Strauss, Joseph. AU - Brakhage, Axel A. PY - 2011/8/23. Y1 - 2011/8/23. N2 - Sequence analyses of fungal genomes have revealed that the potential of fungi to produce secondary metabolites is greatly underestimated. In fact, most gene clusters coding for the biosynthesis of antibiotics, toxins, or pigments are silent under standard laboratory conditions. Hence, it is one of the major challenges in microbiology to uncover the mechanisms required for pathway activation. Recently, we discovered that intimate physical interaction of the important model fungus Aspergillus nidulans with the soil-dwelling bacterium Streptomyces rapamycinicus specifically ...
The enzyme α-L-rhamnosidase [E.C.3.2.1.40] specifically cleaves terminal α-L-rhamnose from a large number of natural products containing glycosides. This property provides this enzyme an important biotechnological application including removal of bitterness from citrus fruit juices, enhancement of grape wine aroma, removal of hesperidin crystals from orange juices, tomato pulp digestion and also help in conversion of clinical important steroids. In this study, production of α-L-rhamnosidase in submerged state fermentation from Aspergillus flavus was optimized using Taguchi DOE methodology. This statistical method provide the study of interaction of a large number of factors at different levels settings with a small number of experimental runs which leads to considerable economy in time and cost for the process optimization. The objective of this research was to determine the significant parameters for the production of α-L-rhamnosidase by Aspergillus flavus in submerged
Moraes, A. M. L., M. Corrado, V. L. Holanda, G. L. Costa, M. Ziccardi, R. de Lourenço-de-Oliveira & P. C. Oliveira. Aspergillus from Brazilian mosquitoes - I. Genera Aedes and Culex from Rio de Janiero State, Mycotaxon 78: 413-422. 2001.. ABSTRACT: As part of an ongoing survey of potential biological control fungi from insects in Brazil. aspergilli were isolated from 625 mosquitoes belonging to 17 species in the genera Aedes and Culex. Two hundred and fifteen isolates belonging to 17 Aspergillus species were found. Aspergillus niger, Aspergillus flavus and Aspergillus nidulans were the most frequently isolated species. Two other species, Aspoergillus fischerianus and Aspergillus heteromorphus were new records for insects. The macro- and microcharacteristics of the Brazilian isolates are compared to those in previously published descriptions. The habitat and geographical distribution of these fungi in Brazil is reviewed.. KEYWORDS: biological control, taxonomy, entomogenous fungi. NOMENCLATURAL ...
Objective: To report the cases of 6 patients with fungus ball caused by Aspergillus fumigatus (aspergilloma) in the pleural cavity. Methods: Between 1980 and 2009, 391 patients were diagnosed with aspergilloma at the Santa Casa Hospital Complex in Porto Alegre, Brazil. The diagnosis of aspergilloma in the pleural cavity was made through imaging tests revealing effusion and pleural thickening with air-fluid level; direct mycological examination revealing septate hyphae, consistent with Aspergillus sp.; and positive culture for A. fumigatus in the surgical specimen from the pleural cavity. Results: Of the 391 patients studied, 6 (2%) met the established diagnostic criteria. The mean age of those 6 patients was 48 years (range, 29-66 years), and 5 (83%) were male. The most common complaints were cough, expectoration, and hemoptysis. Four patients (67%) had a history of tuberculosis that had been clinically cured. All of the patients were submitted to surgical removal of the aspergilloma, followed ...
In an application of the presented high-density microarray, we identify a carbon source-based response conserved in three aspergilli. The design of the study involving three different species, grown on three different defined minimal media, at three different values of pH, increases the likelihood of the found genes to be the true conserved core response to growth on xylose and not responses relying on an extra factor in addition to xylose (with the possible exception of abundant oxygen). We also believe this approach validates our argument that the xylanolytic transcriptional activator XlnR is a conserved system, even though it has not previously been studied in A. nidulans. Backed by the finding that the 5′-GGNTAAA-3′ motif is present and in some cases conserved as syntenic regions in all three species, we propose that the motif is indeed a XlnR motif and conserved in A. nidulans, A. niger, and A. oryzae. As a point of interest, a study of the homologous genes and their promoter regions ...
The aim of present study was to investigate the bioactivity (antibacterial, antifungal and cytotoxicity etc.) of the ethylacetate extract isolated from Streptomyces sp. Aspergillus sp. and Bacillus sp. from sewage of different regions of Bangladesh. The ethylacetate extract of Streptomyces sp., Aspergillus sp. and Bacillus sp. shown modest antibacterial and antifungal activities at the concentration of 200 μg disc-1. The maximum antibacterial and antifungal activities were shown by the Streptomyces sp. The minimum inhibitory concentration of the microbial extracts was between 64 to 128 μg mL-1 against test organisms. Brine srimp lethality bioassay was carried out for cytotoxicity measurement of the extracts and the LC50 values were calculated after probit transformation of the resulting mortality data. All the ethyl acetate extract showed lower cytotoxicity properties (Streptomyces sp. 42.37 μg mL-1, Aspergillus sp. 52.25 μg mL-1 and Bacillus sp. 47.51 μg mL-1) compared with the reference ...
Further evidence on the interspecific protoplast fusion between Aspergillus oryzae and Aspergillus sojae and subsequent haploidization, with special Reference to their production of some hydrolyzing enzymes. (1990 ...
TY - JOUR. T1 - Emergence of Azole Resistance in Aspergillus. AU - Wiederhold, Nathan. AU - Patterson, Thomas F. PY - 2015/10/25. Y1 - 2015/10/25. N2 - Resistance to the azole antifungals itraconazole, voriconazole, and posaconazole in Aspergillus species is a growing concern. This is especially alarming for A. fumigatus, where acquired resistance has been documented in patients with invasive disease caused by this species that were exposed to these agents, as well as in azole-naive individuals. The primary mechanisms of resistance that have been described in clinical strains include different point mutations in the CYP51A gene, which encodes the enzyme responsible for converting lanosterol to ergosterol via demethylation. Some resistant isolates also contain a tandem repeat in the promoter region of this gene that causes increased expression. These mutations, including TR34/L98H and TR46/Y121F/T289A have also been found in the environment in several areas of the world and have been demonstrated ...
1IB4: The X-ray structure of Aspergillus aculeatus polygalacturonase and a modeled structure of the polygalacturonase-octagalacturonate complex.
SWISS-MODEL Repository entry for A1C8U0 (MANF_ASPCL), Mannan endo-1,4-beta-mannosidase F. Aspergillus clavatus (strain ATCC 1007 / CBS 51365 / DSM 816 / NCTC 3887 /NRRL 1)
BioAssay record AID 1094518 submitted by ChEMBL: Antimicrobial activity against Aspergillus flavus at 500 ppm after 72 to 96 hr by disk diffusion method.
RgdA of A. fumigatus is a homolog of the Mbp1 protein of the budding yeast S. cerevisiae, a putative APSES TF. APSES TFs function as key regulators of fungal morphogenesis and development present in Aspergillus genomes, but only the stuA gene has been studied in A. fumigatus (10, 12, 14, 15, 17). The deletion of rgsA resulted in decreased mycelial growth and conidiation and reduced mRNA levels of key asexual development regulators compared to WT (Fig. 2). The mRNA levels of PKA signaling components were higher in the ΔrgdA strain than in WΤ and complemented strains. Furthermore, the ΔrgdA strain showed higher PKA activity in the absence of cAMP (Fig. 3), suggesting the presence of free PKA catalytic subunits in the cytoplasm (18). Based on these observations, we can propose that RgdA of A. fumigatus is necessary for normal growth and proper asexual development, which may involve regulation of the cAMP-PKA signaling pathway.. The Dpr proteins are known to be activated by the stress-activated ...
According to the study of Anti-inflammatory effects of glyceollins derived from soybean by elicitation with Aspergillus sojae by Kim HJ, Sung MK, Kim JS., posted in US National Library of Medicine National Institutes of Health, researchers indicated that Glyceollins exert an anti-inflammatory effect, which is mediated through the inhibition of NF-κB activation in LPS-activated murine RAW264.7 cells. Glyceollins merit further study as potential therapeutic agents for inflammatory disorders ...
Aspergillus flavus is a fungus of the family Trichocomaceae with a worldwide distribution. The mold lives in soil, surviving ... Aflatoxin B1 is an aflatoxin produced by Aspergillus flavus and A. parasiticus. It is a very potent carcinogen with a TD50 3.2 ... "Aspergillus flavus :: Center for Integrated Fungal Research". www.cifr.ncsu.edu. Retrieved 2017-05-08. "Definition of ... The widespread death was later found to be caused by Aspergillus flavus contamination of peanut meal. Twelve patients died of ...
Aspergillus sp., Rhizopus sp., Curvularia sp., Paecilomyces sp., Saprolegnia sp. etc. are main species causing the ...
"Hall of Fame". Aspergillus Website. Archived from the original on 1 September 2009. Lodge Canongate Kilwinning, No. 2 ( ... he makes the very first description of aspergillus (a pathogenic fungus) growing in the lung tissue of humans.[citation needed ...
Aspergillus sp., Flavobacterium, Arthrobacter, Pseudomonas, Streptomyces, Saccharomyces, etc.). Activated sludge systems are ...
This species is second in prevalence after Aspergillus fumigatus as a fungal pathogen in cystic fibrosis lung. It causes ... Histopathologically, hyalohyphomycotic fungi like Scedosporium spp., Aspergillus spp., Fusarium spp. and Petriella spp. are ...
Aspergillus spp. Microsporidia Toxoplasma gondii Cryptosporidium parvum Leishmania spp. Plasmodium spp. "Division of AIDS Anti- ...
Aspergillus spp. Zygomycetes spp. Posaconazole is absorbed within three to five hours. It is predominately eliminated through ... It is also used to treat invasive infections by Candida, Mucor, and Aspergillus species in severely immunocompromised patients ... Posaconazole is used to treat invasive Aspergillus and Candida and fungal infections caused by Scedosporium and Fusarium ...
Aspergillosis is an infection caused by fungi from the genus Aspergillus. The vast majority of cases are caused by Aspergillus ... Aspergillus can form single or multiple nodules which may or may not form a cavity. Whilst usually benign in nature, they can ... Other species of Aspergillus include A. flavus and A. terreus. The major risk factors for chronic pulmonary aspergillosis are ... To confirm Aspergillus nodules as opposed to aspergilloma, these must be seen directly on imaging or confirmed by percutaneous ...
Aspergillus (ficuum) niger fungal strain NRRL 3135 (ATCC 66876) was identified as a promising candidate as it was able to ... Only a few phytases have been described as highly specific for phytic acid, such as phytases from Bacillus sp., Aspergillus sp ... The phytase from the fungus Aspergillus niger is a HAP and is well known for its high specific activity and its commercially ... of Aspergillus niger". Gene. 127 (1): 87-94. doi:10.1016/0378-1119(93)90620-I. ISSN 0378-1119. PMID 8387447. Rodriguez, E.; Han ...
"Aspergillus bronchitis , Aspergillus & Aspergillosis Website". www.aspergillus.org.uk. Kosmidis, Chris; Denning, David W. (1 ... Aspergillus bronchitis is one of the Aspergillosis spectrum of diseases, in which the bronchi are specifically subject to a ...
"Aspergillus bertholletius sp. nov. From Brazil Nuts". PLOS ONE. 7 (8): e42480. Bibcode:2012PLoSO...742480T. doi:10.1371/journal ... closely following on the heels of Aspergillus bertholletius also found in Brazil nuts, described in 2012. P. glabrum and P. ...
CS1 maint: discouraged parameter (link) "Professor Malcolm Richardson PhD, FSB, FRCPath, FISSE". Aspergillus & Aspergillosis ...
Barrs, VR (2013). "Aspergillus felis sp. nov. An emerging agent of aspergillosis in humans, cats and dogs". PLOS ONE. 8 (6): ... Barrs discovered Aspergillus felis, an environmental fungus that causes invasive, intractable disease in cats, dogs and humans ...
... and Aspergillus oryzae, but less effective on Fusarium sp. and Aspergillus niger. The UMY15 strain also proved very effective ...
and the fungus Aspergillus niger, are efficient at removing these toxic compounds. EPSs contain enzymes such as oxidoreductase ... and Zooglea' spp.) galactosaminogalactan (Aspergillus spp.) gellan (Aureomonas elodea and Sphingomonas paucimobilis) glucuronan ...
and Aspergillus spp. show a "paradoxic effect", i.e., they are susceptible to low concentrations but resistant to high ... Beauvais A, Latgé JP (February 2001). "Membrane and cell wall targets in Aspergillus fumigatus". Drug Resistance Updates. 4 (1 ... Echinocandins are fungistatic against some molds (Aspergillus, but not Fusarium and Rhizopus), and modestly or minimally active ... They have fungistatic activity against Aspergillus species. and fungicidal activity against most Candida spp., including ...
In Aspergillus fumigatus, the enzymes needed for gliotoxin biosynthesis are encoded in 13 genes within the gli gene cluster. ... Infections caused by Aspergillus fungus are called aspergillosis. There are many types of aspergillosis, but infections ... The compound is produced by human pathogens such as Aspergillus fumigatus, and also by species of Trichoderma and Penicillium. ... Exposure to fungal species that secrete gliotoxin is common because airborne Aspergillus fungal spores are ubiquitous in many ...
Fungi Aspergillus species. Aspergillus has a propensity to cause infection in people with CGD and of the Aspergillus species, ... Aspergillus fumigatus seems to be most common in CGD. Candida species. Patients with CGD can usually resist infections of ...
... aspergillus; candida; fusarium; hormoconis resinae Fuel companies agree that if left untreated fuel will remain reliable for ...
Kōji-kin (Aspergillus oryzae) spores are another important component of sake. Kōji-kin is an enzyme-secreting fungus. In Japan ... Kobayashi T, Abe K, Asai K, Gomi K, Uvvadi PR, Kato M, Kitamoto K, Takeuchi M, Machida M. (2007). "Genomics of Aspergillus ... Bamforth (2005) places the probable origin of true sake (which is made from rice, water, and kōji mold (麹, Aspergillus oryzae) ... Machida, Masayuki; Yamada, Osamu; Gomi, Katsuya (August 2008). "Genomics of Aspergillus oryzae: Learning from the History of ...
Bahl OP (1970). "Glycosidases of aspergillus niger. II. Purification and general properties of 1,2-alpha-L-fucosidase". J. Biol ...
... fungi like Aspergillus sp. and Histoplasma capsulatum; viruses like Influenza and Adenovirus. Apart from Streptococcus ...
"Aspergillus alliaceus - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2021-02-01. Geoffrey Clough ...
These fungal strains [Aspergillus oryzae FNBR_L35; Fusarium sp. FNBR_B7, FNBR_LK5 and FNBR_B3; Aspergillus nidulans FNBR_LK1; ... The fungus Aspergillus sclerotiorum CBMAI 849 showed the best performance with regard to pyrene (99.7%) and benzo[a]pyrene ( ... Aspergillus niger recorded maximum decolorization of the dye Basic fuchsin (81.85%) followed by Nigrosin (77.47%), Malachite ... A variety of fungi, such as Pleurotus, Aspergillus, Trichoderma has proven to be effective in the removal of lead, cadmium, ...
"Aspergillus Genome Database (AspGD)". Stanford University. Kessler D, Gruen GC, Heider D, Morgner J, Reis H, Schmid KW, ... Shown in parenthesis are the equivalent names in the model organisms Saccharomyces cerevisiae and Aspergillus nidulans. RAB13 ...
lycopersici and Aspergillus fumigatus. Kanini, Grammatiki S.; Katsifas, Efstathios A.; Savvides, Alexandros L.; Karagouni, ...
Barker SA, Carrington TR (1953). "Studies of Aspergillus niger. Part II. Transglycosidation by Aspergillus niger". J. Chem. ...
Marshall AC, Kidd SE, Lamont-Friedrich SJ, Arentz G, Hoffmann P, Coad BR, Bruning JB (March 2019). "Aspergillus fumigatus ...
Aspergillus acid proteinase, Aspergillus aspartic proteinase, Aspergillus awamori acid proteinase, Aspergillus carboxyl ... Aspergillus saitoi acid proteinase, pepsin-type aspartic proteinase, Aspergillus niger acid proteinase, sumizyme AP, proctase P ... Does not clot milk This enzyme is found in a variety of Aspergillus species. Trypsinogen Kovaleva GG, Shimanskaya MP, Stepanov ... Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus". Journal of ...
Aspergillus carbonarius, Aspergillus glaucus, Aspergillus melleus, and Aspergillus niger. Because Aspergillus niger is used ... Members of the ochratoxin family have been found as metabolites of many different species of Aspergillus, including Aspergillus ... Ochratoxin production by the Aspergillus ochraceus group and Aspergillus alliaceus. Appl. Environ. Microbiol. 68:2326-2329. ... Aspergillus terreus and Aspergillus niveus), including certain strains of Penicillium camemberti (used to produce cheese) and ...
In Kenya, Aspergillus flavus is the most prevalent and has been associated with several acute and chronic aflatoxin outbreaks ... Aspergillus spp. were first isolated from soils before the identification and determination of their aflatoxigenicity. Further ... These bacterial species have long been associated with biological control of several plant pathogens including Aspergillus spp ... Aflatoxins are carcinogenic chemical metabolites produced by Aspergillus spp. of the section Flavi. ...
The genome sequences of three Aspergillus species-Aspergillus fumigatus, Aspergillus nidulans, and Aspergillus oryzae-were ... Aspergillus fumigatus is a species of fungus in the genus Aspergillus, and is one of the most common Aspergillus species to ... The Aspergillus Trust A registered UK charity engaged in support of sufferers of aspergillus disease worldwide and research ... Aspergillus fumigatus grown on certain building materials can produce genotoxic and cytotoxic mycotoxins, such as gliotoxin.[7] ...
Aspergillus oryzae, known in English as koji (Japanese: 麹, Hepburn: kōji), is a filamentous fungus (a mold) used in Chinese and ... Fujita, Chieko, Tokyo Foundation Koji, an Aspergillus *^ Shurtleff, W.; Aoyagi, A. History of Koji - Grains and/or Soybeans ... Aspergillus oryzae genome from the Database of Genomes Analysed at NITE (DOGAN) ... The genome of A. oryzae is thus one-third larger than that of two related Aspergillus species, the genetics model organism A. ...
Vernacular names [edit wikidata Category:Aspergillus linked to current category] [edit wikidata Aspergillus main topic of ... A. pseudoglaucus, A. monodii, A. Aspergillus, A. appendiculatus, A. intermedius, A. acidus, A. aculeatus, A. aeneus, A. affinis ... Media in category "Aspergillus". The following 200 files are in this category, out of 580 total. ... Retrieved from "https://commons.wikimedia.org/w/index.php?title=Category:Aspergillus&oldid=258638171" ...
The resistance can occur in the environment and in patients who are sick with an Aspergillus infection and have been taking ... Aspergillus can develop antifungal resistance and cause illness. ... Antifungal resistance is emerging in one type of Aspergillus ... Azole-Resistant Aspergillus Fumigatus. (A. fumigatus). Antifungal resistance happens when fungi develop the ability to survive ... Multidrug-resistant Aspergillus fumigatus carrying mutations linked to environmental fungicide exposure - three states, 2010- ...
... the fungi Aspergillus flavus and A. parasiticus, which grow on improperly stored grains and peanuts. Aflatoxin B is one of the ... Other articles where Aspergillus parasiticus is discussed: cancer: Initiators: … ... the fungi Aspergillus flavus and A. parasiticus, which grow on improperly stored grains and peanuts. Aflatoxin B is one of the ...
Aspergillus nidulans. Definition. Aspergillus nidulans is a filamentous soil fungus in the phylum Ascomcyetes. It is a fungal ... Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans *Kirstin Scherlach ...
Aspergillus sp. IBT 27921. ›Aspergillus sp. KACC 41955. ›Aspergillus sp. KACC 42090. ›Aspergillus turcosus S.B. Hong, Frisvad ...
Aspergillus sp. NRRL 179. ›Aspergillus waksmanii Hubka, S.W. Peterson, Frisvad & M. Kolarik 2013. ›NRRL 179. ›Neosartorya sp. ...
Aspergillus consists of 837 species of fungi. Aspergillus is defined as a group of conidial fungi-that is, fungi in an asexual ... List of Aspergillus species Mold health issues Sick building syndrome Bennett JW (2010). "An Overview of the Genus Aspergillus ... Aspergillus are found in millions in pillows. Species of Aspergillus are important medically and commercially. Some species can ... US 6069146 "GRAS Notification for Acid Lactase from Aspergillus oryzae Expressed in Aspergillus niger". Archived from the ...
Aspergillus infection) is a fungal infection. Symptoms and signs of Aspergillus infection depend on the type of fungus involved ... An Aspergillus infection is a fungal infection. Signs and symptoms can include cough, shortness of breath, wheezing, bloody ... home/infectious disease center/ infectious disease a-z list/ aspergillus infection (aspergillosis) center ...
Aspergillus fumigatus. A. fumigatus causes more infections worldwide than any other mould. Four percent of all patients dying ... Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.. Nierman WC, Pain A, Anderson MJ, ... Andrew Brass at the University of Manchester, were initially funded to carry out a pilot genomic analysis of Aspergillus ...
You are Here: Home , Agronomy , Crop Management Guides , Corn Insect & Disease Guide , Aspergillus Ear Rot ...
Aspergillus primulinus growing on CYA plate Aspergillus primulinus growing on MEAOX plate Udagawa, S.; Toyazaki, N.; Tsubouchi ... Aspergillus primulinus (also named Neosartorya quadricincta and Neosartorya primulina) is a species of fungus in the genus ... 47:359-366 Samson, R.A.; Hong, S.; Peterson, S.W.; Frisvad, J.C.; Varga, J. (2007). "Polyphasic taxonomy of Aspergillus section ... Aspergillus. It is from the Fumigati section. Several fungi from this section produce heat-resistant ascospores, and the ...
Aspergillus niger CBS 513.88 Aspergillus niger CBS 513.88. Aspergillus niger CBS 513.88 RefSeq Genome ... Juhász A et al., "Comparative analysis of the complete mitochondrial genomes of Aspergillus niger mtDNA type 1a and Aspergillus ... Aspergillus; Aspergillus niger; Aspergillus niger CBS 513.88 ... Aspergillus niger CBS 513.88. Aspergillus niger CBS 513.88 ... The Aspergillus niger reference sequence (RefSeq) genome is provided by the NCBI and is available here. The protein coding ...
Mullins J. (1994) Aspergillus and Aerobiology. In: Powell K.A., Renwick A., Peberdy J.F. (eds) The Genus Aspergillus. ... Solomon W.R. and Burge H.P.(1975) Aspergillus fiimigatus levels in and out of doors in urban air. J. All. Clin Immunol. 57, 46- ... Solomon W.R., Burge H.P. and Boise, J.P. (1978) Airborne Aspergillus fiimigatus levels outside and within a large clinical ... Mullins J. (1974) The ecology of Aspergillus fiimigatus (Fres.) PhD Thesis, University of Wales.Google Scholar ...
Topical Treatment of Aspergillus for Dogs. There are two primary forms of treatment for aspergillus, and topical is generally ... Before Aspergillus Treatment. Before you can begin to treat your pet for aspergillus, youll need to first be sure that it is ... Systemic Treatment for Aspergillus. The second method of treating aspergillus is less commonly seen than topical treatment ... Systemic treatments of aspergillus have success rates of only around 70%. This makes it a good option in some cases, but ...
crnA encodes a nitrate transporter in Aspergillus nidulans - May 15, 1991. *crnA encodes a nitrate transporter in Aspergillus ... crnA encodes a nitrate transporter in Aspergillus nidulans. S E Unkles, K L Hawker, C Grieve, E I Campbell, P Montague, J R ... crnA encodes a nitrate transporter in Aspergillus nidulans. S E Unkles, K L Hawker, C Grieve, E I Campbell, P Montague, J R ... crnA encodes a nitrate transporter in Aspergillus nidulans. S E Unkles, K L Hawker, C Grieve, E I Campbell, P Montague, and J R ...
The picture shows an ,I,Aspergillus,/I, conidiophore with conidia (spores) budding off (tissues stained blue). ,I,Aspergillus,/ ... SEM Aspergillus mould producing spores (conidia) Scanning electron micrograph of Aspergillus producing spores, computer- ... The picture shows an Aspergillus conidiophore with conidia (spores) budding off (tissues stained blue). Aspergillus is a genus ... Aspergillus,/I, producing spores, computer-coloured green. ...
Keywords: fungal sinusitis; allergy; Aspergillus; dematiaceous fungi; epidemiology; pathogenesis; diagnosis; management fungal ... This article belongs to the Special Issue Aspergillus fumigatus: From Diagnosis to Therapy) ... Chakrabarti, A.; Kaur, H. Allergic Aspergillus Rhinosinusitis. J. Fungi 2016, 2, 32. ... Chakrabarti A, Kaur H. Allergic Aspergillus Rhinosinusitis. Journal of Fungi. 2016; 2(4):32. ...
2. Aspergillus Species. Aspergillus species are classified into the fungal division Ascomycota. Aspergillus species are ... Some species that exhibit virulence against humans include Aspergillus fumigatus, Aspergillus niger, Aspergillus terreus, and ... R. Greene, K. Shibuya, and T. Ando, "Histology and radiology," in Aspergillus fumigatus and Aspergillosis, J. P. Latgé and W. J ... Histopathological Implications of Aspergillus Infection in Lung. Naobumi Tochigi,1 Yoichiro Okubo,1 Tsunehiro Ando,1 Megumi ...
Its ordered when a doctor suspects that you have an infection caused by the fungus Aspergillus. ... Aspergillus precipitin is a lab test performed on your blood. ... What is an aspergillus precipitin test?. Aspergillus precipitin ... Understanding aspergillus infection. Aspergillosis is a fungal infection caused by Aspergillus, a fungus found in homes and ... Aspergillus precipitin detects the type and quantity of specific Aspergillus antibodies in the blood. Antibodies are ...
... Naobumi Tochigi,1 Yoichiro Okubo,1 Tsunehiro Ando,1 Megumi ... While it has been largely accepted that Aspergillus species is recognized by cellular receptors and attacked by neutrophils, ...
How Aspergillus develops antifungal resistance and causes illness ... Aspergillus fumigatus (A. fumigatus) is a fungus in the ... Learn how Aspergillus develops antifungal resistance in the environment. *Learn how Aspergillus develops antifungal resistance ... Aspergillus fumigatus (A. fumigatus) is a fungus in the environment that is common in air. People can develop severe infections ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative ... Aspergillus Antibody by CF. 4. Aspergillus Galactomannan Antigen by EIA. 5. Aspergillus Precipitin. 6. Aspergillus Niger IgE. 7 ... Allergen, Fungi & Molds, Aspergillus fumigatus. 9. Allergen, Fungi & Molds, Aspergillus fumigatus IgG. 10. Anti-GBM Antibodies ... Bio-Rad Platelia Aspergillus EIA. 2. Aspergillus Antibody by ID. 3. ...
Aspergillus mold can be found in soil, foods, fresh water, and other natural sources including compost, barley, tobacco, and ... Aspergillus infection can also result in allergic bronchopulmonary aspergillosis (ABPA), a condition where airway colonization ... 5Aspergillus mold can also grow on ceiling and walls where water damage has occurred.6 ... 7 Testing for Aspergillus precipitating IgG antibodies has been shown to be of some clinical utility in the assessment of ...
Aspergillus terreus ATCC ® 10690™ Designation: QM 82-j [CBS 377.64, DSM 1958, IFO 6346, IMI 321320, IMI 45543, NRRL 571, QM 82J ... Aspergillus terreus Thom (ATCC® 10690™) Strain Designations: QM 82-j [CBS 377.64, DSM 1958, IFO 6346, IMI 321320, IMI 45543, ... Crystallization and characterization of polyamine oxidase from Aspergillus terreus. Agric. Biol. Chem. 44: 2749-2751, 1980. ...
Large-scale genome comparisons have shown that no gene sets are shared exclusively by both Aspergillus fumigatus and any other ... Aspergillus fumigatus: saprophyte or pathogen? Curr Opin Microbiol. 2005 Aug;8(4):385-92. doi: 10.1016/j.mib.2005.06.017. ... Large-scale genome comparisons have shown that no gene sets are shared exclusively by both Aspergillus fumigatus and any other ...
Aspergillus fumigatus Basics Laboratory Metabolites Adverse health reactions Specific settings Diagnostic Bibliography Basics A ... Aspergillus. There are over 200 named species of Aspergillus {3318}.The taxonomic fungal database administrated by the ... Aspergillus fumigatus is however the most important species in Aspergillus genus causing health problems. This species has been ... Density and molecular epidemiology of Aspergillus in air and relationship to outbreaks of Aspergillus infection. J Clin ...
  • The genome sequences of three Aspergillus species- Aspergillus fumigatus , Aspergillus nidulans , and Aspergillus oryzae -were published in Nature in December 2005. (wikipedia.org)
  • The genome of A. oryzae is thus one-third larger than that of two related Aspergillus species, the genetics model organism A. nidulans and the potentially dangerous A. fumigatus . (wikipedia.org)
  • Aspergillus nidulans is a filamentous soil fungus in the phylum Ascomcyetes. (nature.com)
  • The nucleotide sequence of the Aspergillus nidulans crnA gene for the transport of the anion nitrate has been determined. (pnas.org)
  • Infection: Aspergillus Nidulans in the Central Nervous System. (bio.net)
  • the biopsy confirmed the fungus was Aspergillus, but the cultures would not grow so it could not be confirmed the fungus was Nidulans. (bio.net)
  • Asexual reproductive development can be initiated in Aspergillus nidulans in the presence of excess nutrients through artificial induction of the developmental regulatory genes brlA or abaA by fusing the genes to the promoter from the alcohol dehydrogenase I gene (alcA) and culturing cells in the presence of an inducing alcohol. (pnas.org)
  • Non-circadian light inducible rhythm in Aspergillus nidulans - Scientific Figure on ResearchGate. (kenyon.edu)
  • A. nidulans was the first Aspergillus species to have its entire genome sequenced, and considering that A. nidulans is sexually reproductive, it contains a well-developed genetics system. (kenyon.edu)
  • The use of A. nidulans as a model species allows for the understanding of other Aspergillus species (e.g. (kenyon.edu)
  • Asexual Sporulation in Aspergillus nidulans. (kenyon.edu)
  • Analysis of Aspergillus nidulans metabolism at the genome-scale. (kenyon.edu)
  • Aspergillus fumigatus and Aspergillus nidulans ). (emlab.com)
  • Two new Aspergillus nidulans group members from Wyoming soils. (springer.com)
  • Isolation of a sexual sporulation hormone from Aspergillus nidulans. (asm.org)
  • In Kenya, Aspergillus flavus is the most prevalent and has been associated with several acute and chronic aflatoxin outbreaks in the past. (mdpi.com)
  • the fungi Aspergillus flavus and A. parasiticus , which grow on improperly stored grains and peanuts. (britannica.com)
  • As of 2008, a further seven Aspergillus species have had their genomes sequenced: the industrially useful A. niger (two strains), A. oryzae, and A. terreus, and the pathogens A. clavatus, A. fischerianus (Neosartorya fischeri), A. flavus, and A. fumigatus (two strains). (wikipedia.org)
  • 2 (2,86) 2 Aspergillus flavus 2 (2,86) Fusarium tricinctum 1 (1,43) Aspergillus ochraceus 1 (1,43) 3 Penicillium expansum 2 (2,86) Eurotium herbariorum 2 (2,86) 4 Fusarium poae 5 (7,14) Cladosporium herbarum 5 (7,14) Total 70 (100) FIGURA 1. (thefreedictionary.com)
  • Aspergillus flavus (green mold) conidiophore. (kenyon.edu)
  • The most infamous species of this genus is Aspergillus flavus , which produces aflatoxin . (kenyon.edu)
  • Two Aspergillus species, A. flavus and A. parasiticus , are known to produce toxins only at acidic levels of pH. (kenyon.edu)
  • FAPP MIXTURE (aspergillus flavus var. (nih.gov)
  • MIXED ASPERGILLUS (aspergillus flavus var. (nih.gov)
  • Aspergillosis of the paranasal sinuses is infrequent and usually involves the species Aspergillus fumigatus or Aspergillus flavus . (frontiersin.org)
  • Dentre as centenas de espécies fúngicas pertencentes ao gênero Aspergillus, A. flavus vem se destacando devido à sua importância no âmbito da medicina e da agricultura. (usp.br)
  • Among Among the several hundred fungal species belonging to the Aspergillus genus, the A. flavus have been recognized by its importance on medical and agriculture ambit. (usp.br)
  • Contamination of maize ( Zea mays L.) with aflatoxin, produced by the fungus Aspergillus flavus Link, has severe health and economic consequences. (usda.gov)
  • A synoptic key and evaluation of species in the Aspergillus flavus group. (springer.com)
  • Aspergillus fumigatus (69%) and Aspergillus flavus (15%) were common species from the isolated culture. (scirp.org)
  • Aspergillus fumigatus is a species of fungus in the genus Aspergillus , and is one of the most common Aspergillus species to cause disease in individuals with an immunodeficiency . (wikipedia.org)
  • Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. (sanger.ac.uk)
  • This condition comes about when your pet comes into direct contact with the aspergillus fungus. (vetinfo.com)
  • Aspergillus primulinus (also named Neosartorya quadricincta and Neosartorya primulina) is a species of fungus in the genus Aspergillus. (wikipedia.org)
  • It's ordered when a doctor suspects that you have an infection caused by the fungus Aspergillus . (healthline.com)
  • Aspergillosis is a fungal infection caused by Aspergillus, a fungus found in homes and outdoors. (healthline.com)
  • This helps to determine presence of Aspergillus and how the fungus might be affecting the body. (healthline.com)
  • Aspergillus fumigatus (A. fumigatus) is a fungus in the environment that is common in air. (cdc.gov)
  • Major OTA producing fungus in northern Europe is Penicillium verrucosum, and more important in warmer climatic zone is Aspergillus ochraceus [30]. (thefreedictionary.com)
  • Research team from the University of Jena (Germany) clarifies the mechanism of gliotoxin, a mycotoxin from the fungus Aspergillus fumigatus. (news-medical.net)
  • The fungus Aspergillus fumigatus occurs virtually everywhere on Earth, as a dark grey, wrinkled cushion on damp walls or in microscopically small spores that blow through the air and cling to wallpaper, mattresses and floors. (news-medical.net)
  • Aspergillus niger is a fungus and one of the most common species of the genus Aspergillus . (bionity.com)
  • Aspergillus fumigatus, a filamentous fungus, produces GPI-anchored molecules, some of them being essential in the construction of the cell wall. (biomedsearch.com)
  • Coloured scanning electron micrograph (SEM) of the fungus Aspergillus sp. (sciencephoto.com)
  • The spores of the fungus Aspergillus are like small, dry seeds that can easily be spread by draughts or the wind. (thepoultrysite.com)
  • The risk of a serious bloom of Aspergillus is high when 0.5 per cent of the hatching eggs show clear infection with a visible growth of the fungus. (thepoultrysite.com)
  • DSM is publishing a paper in the February 2007 issue of the renowned scientific journal "Nature Biotechnology" announcing the release of the DNA sequence of the fungus Aspergillus niger. (allaboutfeed.net)
  • Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220. (semanticscholar.org)
  • Here, we have synthesized the silver nanoparticles (AgNPs) by using the soil fungus Aspergillus niger 2587. (scirp.org)
  • Of these, ABPA can be regarded as being representative of allergic aspergillosis, where the pathological implications can be described as involving the absence of any contact between pathogen and extracellular matrix of the host, although damaged immune reactions result in Aspergillus species colonization in large and small airways. (hindawi.com)
  • Aspergillus infection can also result in allergic bronchopulmonary aspergillosis (ABPA), a condition where airway colonization of individuals with asthma or cystic fibrosis results in increased inflammation and destruction of bronchial structural elements. (labcorp.com)
  • Neosartorya udagawae ( Aspergillus udagawae ), an Emerging Agent of Aspergillosis: How Different Is It from Aspergillus fumigatus ? (asm.org)
  • The spectrum of aspergillus airways disease ranges from allergic asthma characterised by an IgE-mediated immune response, to allergic bronchopulmonary aspergillosis, where additionally there is airway fungal colonisation and an IgG-mediated immune response leading to bronchiectasis and fibrosis. (springer.com)
  • A. niger is less likely to cause human disease than some other Aspergillus species, but if large amounts of spores are inhaled, a serious lung disease, aspergillosis can occur. (bionity.com)
  • Aspergillosis is particularly frequent among horticultural workers who inhale peat dust, which can be rich in Aspergillus spores. (bionity.com)
  • In patients with acute invasive aspergillosis, the probability that the patient harbours a resistant strain depends on the emergence of resistant strains in the environment (acquired resistance due to CYP51A mutations and/or natural resistant Aspergillus species). (nih.gov)
  • Aspergillosis is the disease cause by Aspergillus. (webwire.com)
  • Symptoms of an aspergillus infection, or aspergillosis, depend upon the type of the disease but generally include coughing up blood or mucus plugs, as Mayo Clinic states. (reference.com)
  • An aspergillus infection may spread to the skin, brain, heart or kidneys, causing invasive pulmonary aspergillosis, which is the most serious type of aspergillosis, explains Mayo Clinic. (reference.com)
  • Day-old chicks with signs of Aspergillosis are infected by the spores of Aspergillus species, among which Aspergillus fumigatus is the most common. (thepoultrysite.com)
  • The performance characteristics of aspergillus DNA detection for the diagnosis of invasive aspergillosis are unknown. (uiowa.edu)
  • For acute diagnosis of invasive aspergillosis in susceptible patients with hematologic malignancies, serial monitoring with the "Aspergillus Galactomannan Antigen-Blood" (LAB2640) is the preferred screen. (uiowa.edu)
  • Aspergillus belonging to section Fumigati is the main causative agent of aspergillosis in birds, it is commonly found in bed, soil and decomposing organic matter or in feed. (scielo.br)
  • Resistance to azoles in Aspergillus fumigatus is emerging as a global health problem, through both the use of azoles in the environment and the prolonged use in the management of patients with invasive aspergillosis. (bruker.com)
  • Serum galactomannan versus a combination of galactomannan and polymerase chain reaction-based Aspergillus DNA detection for early therapy of invasive aspergillosis in high-risk hematological patients: a randomized controlled trial. (clinicaltrials.gov)
  • Several species of Aspergillus, including A. niger and A. fumigatus, will readily colonise buildings, favouring warm and damp or humid areas such as bathrooms and around window frames. (wikipedia.org)
  • Comparative analysis of the complete mitochondrial genomes of Aspergillus niger mtDNA type 1a and Aspergillus tubingensis mtDNA type 2b. (nih.gov)
  • Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. (nih.gov)
  • Trancriptional landscape of Aspergillus niger a. (scoop.it)
  • 660050: Aspergillus niger Precipitating. (labcorp.com)
  • . Aspergillus niger is part of a group of species named Aspergillus section Nigri , formerly known as « Aspergillus niger group »: all species of this section have black conidial heads. (inspq.qc.ca)
  • In the following text, Aspergillus niger refers to the species A. niger, unless otherwise stated. (inspq.qc.ca)
  • The species within the Aspergillus niger groupare hyaline hyphomycetes anamorphs: some have known teleomorph forms included in the genera Eupenicillium , Talaromyces , Hamigera and Trichocoma . (inspq.qc.ca)
  • The species Aspergillus niger has no known teleomorph stage. (inspq.qc.ca)
  • Even though it is considered an ubiquitous innocuous contaminant, Aspergillus niger can, in special rare circumstances, cause opportunistic human diseases {509} (see Health effects section). (inspq.qc.ca)
  • Aspergillus niger is prevalent in residential areas, even in urban settings, and is recovered in both indoor and outdoor air samples. (inspq.qc.ca)
  • Aspergillus niger is also prevalent in the indoor environment. (inspq.qc.ca)
  • Xylanase activity from Aspergillus niger and Aspergillus ochraceus using mixture of corn cobs and wheat bran increased (18) % these results were reported by (19). (thefreedictionary.com)
  • A. niger is included in Aspergillus subgenus Circumdati , section Nigri . (bionity.com)
  • Search Results for aspergillus niger var. (nih.gov)
  • A-21 (alternaria alternata, aspergillus niger var. (nih.gov)
  • ASPERSAN (aspergillus niger var. (nih.gov)
  • CANDIDA (ammoniac, aspergillus niger var. (nih.gov)
  • Biotransformation of quinazoline and phthalazine by Aspergillus niger. (sigmaaldrich.com)
  • Cultures of Aspergillus niger NRRL-599 in fluid Sabouraud medium were grown with quinazoline and phthalazine for 7 days. (sigmaaldrich.com)
  • Aspergillus niger is a micro-organism that DSM uses for the production of enzymes and other compounds, such as citric acid. (allaboutfeed.net)
  • At the beginning of this century, DSM started work on the determination of the complete DNA sequence of Aspergillus niger and the identification of the functions of the different genes. (allaboutfeed.net)
  • Dr Hein Stam, Principal Scientist Applied Genomics and Fermentation who coordinated the publication of the genome: "Further research on Aspergillus niger could help identify other possible uses of this micro-organism (such as in the sustainable use of raw materials). (allaboutfeed.net)
  • how to do Aspergillus Niger count? (protocol-online.org)
  • Hi, I'm facing problem in counting my Aspergillus Niger. (protocol-online.org)
  • I grew the Aspergillus Niger on Sabouraud dextrose agar with chloramphenicol(SDAC), incubated for 5 days. (protocol-online.org)
  • S. Namita and P. Soam, "Aspergillus niger Metabolites Efficacies against the Mosquito Larval (Culex quinquefasciatus, Anopheles stephensi and Aedes aegypti) Population after Column Chromatography," American Journal of Microbiology, Vol. 2, No. 1, 2011, pp. 15-20. (scirp.org)
  • Aspergillus consists of 837 species of fungi. (wikipedia.org)
  • Aspergillus is defined as a group of conidial fungi-that is, fungi in an asexual state. (wikipedia.org)
  • Any of various fungi of the genus Aspergillus, which includes many common molds. (thefreedictionary.com)
  • Are Infections Caused by Aspergillus Fungi Developing Drug Resistance? (webwire.com)
  • Although the study group was small, the findings appear to indicate that there is a growing dissemination of drug-resistant strains of Aspergillus fungi. (webwire.com)
  • In the next CSF sample, culture to fungi was positive to Aspergillus sp and the immunodiffusion test showed presence of antibodies against Aspergillus sp . (scielo.br)
  • Found in microbial communities around the world, Aspergillus fungi are pathogens, decomposers, and important sources of biotechnologically-important enzymes. (infectioncontroltoday.com)
  • Aspergillus (/ˌæspərˈdʒɪləs/) is a genus consisting of a few hundred mould species found in various climates worldwide. (wikipedia.org)
  • With DNA evidence, all members of the genus Aspergillus are members of the Ascomycota. (wikipedia.org)
  • In: Powell K.A., Renwick A., Peberdy J.F. (eds) The Genus Aspergillus. (springer.com)
  • Three Aspergillus genome manuscripts were published in Nature in December 2005 thus establishing Aspergillus as the leading filamentous fungal genus for comparative genomic studies. (kenyon.edu)
  • 5] As a model organism, this species' diversified genome (unlike its relatives) allows for a more developed understanding of other species in the Aspergillus genus. (kenyon.edu)
  • This sort of reproduction is not common within the Aspergillus genus. (kenyon.edu)
  • Species in the genus Aspergillus are commonly found in many areas of life on earth, such as in soil, plant debris, water (freshwater or marine), or the air. (kenyon.edu)
  • The genus Aspergillus is important economically, ecologically and medically. (emlab.com)
  • We present a description of a rare but dangerous case of fungal meningitis caused by Aspergillus terreus in an immunocompetent patient with a history of sinus disease. (frontiersin.org)
  • Therefore, koji mold such as Aspergillus oryzae is used to first break down the starches into simpler sugars. (wikipedia.org)
  • Genome sizes for sequenced species of Aspergillus range from approximately 29.3 Mb for A. fumigatus to 37.1 Mb for A. oryzae while the numbers of predicted genes vary from approximately 9926 for A. fumigatus to approximately 12,071 for A. oryzae . (kenyon.edu)
  • Aspergillus fumigatus is the most frequent cause of invasive fungal infection in immunosuppressed individuals, which include patients receiving immunosuppressive therapy for autoimmune or neoplastic disease, organ transplant recipients, and AIDS patients. (wikipedia.org)
  • An Aspergillus infection is a fungal infection. (medicinenet.com)
  • Nolard-Tintigner, N. and Beguin, H. (1990) Epidemiology of Aspergillus infection in the hospital environment. (springer.com)
  • Aspergillus is a relatively common condition among dogs that involves a fungal infection of the nose and nasal passageways. (vetinfo.com)
  • While it has been largely accepted that Aspergillus species is recognized by cellular receptors and attacked by neutrophils, the radiological and macroscopic findings linking infection with neutropenia remain unconfirmed. (hindawi.com)
  • We report a case of Aspergillus felis infection in a patient emerging zoonosis. (cdc.gov)
  • What Are Some of the Symptoms of an Aspergillus Infection? (reference.com)
  • The results show that the Aspergillus is presented in all used samples (100% of the infection) in the form of spores or hyphae and all infected samples have mutant p53 molecules (p53 was located in Aspergillus spores and hyphae). (scirp.org)
  • Aspergillus fumigatus from canine nasal infection. (merckvetmanual.com)
  • Cryptococcus neoformans infection is still the most common CNS fungal infection, whereas Aspergillus and Mucor are relatively uncommon causes of CNS infection ( Qi, 2014 ). (frontiersin.org)
  • Initially, infection by Aspergillus will be found during the routine analysis of unhatched eggs. (thepoultrysite.com)
  • Invasive Aspergillus infection (IAI) is the second most common invasive fungal infection among patients with hematological malignancies. (springer.com)
  • Systemic infection with Aspergillus spp. (springer.com)
  • Additionally, patients who have to take immunosuppressive drugs other than corticosteroids or those suffering from inherited immunodeficiency may develop a severe Aspergillus infection. (springer.com)
  • Johnson EM, Oakley KL, Radford SA, Moore CB, Warn P, Warnock DW et al (2000) Lack of correlation of in vitro amphotericin B susceptibility testing with outcome in a murine model of Aspergillus infection. (springer.com)
  • The conidia (2-5 µm in diameter) may be spherical to elongate and form chains which may radiate (e.g., in Aspergillus versicolor ) or form themselves into compact columns (e.g. (emlab.com)
  • In coffee, Aspergillus ochraceus is an important toxin source dependent on the management of fruits and coffee beans after harvest and storage. (thefreedictionary.com)
  • Yeast extract was also reported as the best nitrogen source for Candida utilis, Saccharomyces cerevisiae [6] and Aspergillus ochraceus [11]. (thefreedictionary.com)
  • In addition occasionally ochratoxin A produced by Aspergillus ochraceus or Aspergillus carbonarius may occur in chillies. (thefreedictionary.com)
  • Ochratoxin A first in South Africa was isolated from Aspergillus Ochraceus [5]. (thefreedictionary.com)
  • 021 (Mu) g/g) at 30oC in corn by the Aspergillus ochraceus where as it was minimum at 5oC in wheat by both species i. (thefreedictionary.com)
  • Aspergillus carbonarius and Aspergillus ochraceus produce the toxin ochratoxin A (OTA), which contaminates grapes and coffee. (kenyon.edu)
  • The Aspergillus ochraceus group: two new species from western soils and a synoptic key. (springer.com)
  • In this article, Aspergillus ochraceus is presented as a new source of tannase with interesting features for biotechnological applications. (scielo.cl)
  • On the structure of two new metabolites isolated from Penicillium paraherquei and aspergillus silvaticus. (aspergillus.org.uk)
  • On spore trap samples, Aspergillus spores are very similar to Penicillium spores. (emlab.com)
  • Hyphal nigeran as a potential phylogenetic marker for Aspergillus and Penicillium species. (springer.com)
  • Aspergillus precipitin detects the type and quantity of specific Aspergillus antibodies in the blood. (healthline.com)
  • The aspergillus precipitin test looks for IgM, IgG, and IgE antibodies in the blood. (healthline.com)
  • A normal test result means that no Aspergillus antibodies were found in your blood. (healthline.com)
  • 6,7 Testing for Aspergillus precipitating IgG antibodies has been shown to be of some clinical utility in the assessment of patients with potential ABPA. (labcorp.com)
  • Antifungal resistance is emerging in one type of Aspergillus called Aspergillus fumigatus ( A. fumigatus ), a common mold in the environment and the leading cause of invasive mold infections in people. (cdc.gov)
  • 3 Resistant Aspergillus infections are also found in people who have not taken azole antifungals, further suggesting that the resistance is partially driven by environmental sources. (cdc.gov)
  • While some species of Aspergillus are known to cause fungal infections, others are of commercial importance. (wikipedia.org)
  • In chronic (and chronically treated) Aspergillus infections,"in-patient" resistance development is possible, especially in the setting of aspergilloma. (nih.gov)
  • Due to the threat of infections from Aspergillus, a number of healthcare facilities now utilize UVGI technologies to help prevent these infections, reported Richard Hayes, President of UltraViolet Devices, Inc. (UVDI), a leading provider of UV-C disinfection technologies. (webwire.com)
  • Infections caused by Aspergillus spp. (frontiersin.org)
  • Susceptibility testing is essential to inform the correct management of Aspergillus infections. (scielo.br)
  • The annotation has been compared with that submitted to GenBank and the results presented at Asperfest 8 with an abstract (Alternative annotation of Aspergillus genomes with multi-genome Gnomon method) available here . (nih.gov)
  • Together with advanced bioinformatics and data analysis tools, new insights are being gained into the functional properties and activities of Aspergillus fungal genomes. (kenyon.edu)
  • Using Aspergillus, we're sequencing a lot of closely-related genomes to highlight and compare the differences between genomes. (infectioncontroltoday.com)
  • A comparative analysis involving these genomes and other Aspergillus genomes-several of which were sequenced by the JGI-was then conducted, and allowed the team to identify biosynthetic gene clusters for secondary metabolites of interest. (infectioncontroltoday.com)
  • Grigoriev added that to date, about 30 Aspergillus genomes have been published, an additional 25 genomes are publicly available from the JGI fungal genomes portal Mycocosm (genome.jgi.doe.gov/Aspergillus), and over 100 genomes are being sequenced and analyzed. (infectioncontroltoday.com)
  • Aspergillus Genomes is a resource for viewing annotated genes arising from various Aspergillus sequencing and annotation projects. (aspergillus.org.uk)
  • If you're using ATCC 16404 - the correct species name is Aspergillus brasiliensis, Folks typically count colonies earlier than 5 days - look every day. (protocol-online.org)
  • The picture shows an Aspergillus conidiophore with conidia (spores) budding off (tissues stained blue). (europeana.eu)
  • Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure. (nih.gov)
  • Microscopically, the asexual fruiting structure of Aspergillus species includes a long stipe (conidiophore), a rounded head (vesicle), and flask shape structures (phialides) from which spores (conidia) are formed. (emlab.com)
  • Here, we compared the novel Aspergillus -specific galactomannoprotein (GP) enzyme-linked immunosorbent assay (ELISA) (Euroimmun Medizinische Labordiagnostika AG) to the established Platelia Aspergillus galactomannan (GM) ELISA (Bio-Rad Laboratories) for the detection of IA. (asm.org)
  • The Platelia Aspergillus enzyme immunoassay (EIA) is a 1-stage immunoenzymatic sandwich microplate assay that detects galactomannan in bronchoalveolar lavage (BAL) specimens. (mayomedicallaboratories.com)
  • The assay uses the rat monoclonal antibody EBA-2, which is directed against Aspergillus galactomannan. (mayomedicallaboratories.com)
  • A monoclonal antibody-galactomannan-monoclonal antibody/peroxidase complex is formed in the presence of Aspergillus antigen. (mayomedicallaboratories.com)
  • The presence or absence of Aspergillus (galactomannan) antigen in the test sample is determined by calculation of an index for the specimen. (mayomedicallaboratories.com)
  • Aspergillus is a member of the phylum Ascomycota . (kenyon.edu)
  • Aspergillus ) ali glavičaste plesni so rod ubikvitarnih (povsod razširjenih) plesni iz debla Ascomycota z značilnim konidijem . (wikipedia.org)
  • Hart S.P. (2018) Lung Diseases Caused by Aspergillus and Pulmonary Eosinophilia. (springer.com)
  • Aspergillus information gateway page at the National Center for Biotechnology Information ( NCBI ). (aspergillus.org.uk)
  • These bacterial species have long been associated with biological control of several plant pathogens including Aspergillus spp. (mdpi.com)
  • More than 60 Aspergillus species are medically relevant pathogens. (wikipedia.org)
  • 100 metre) showed presence of twelve fungal pathogens (Table 4) with exceptionally high frequency of occurrence for Aspergillus fumigatus. (thefreedictionary.com)
  • Aspergillus fumigatus has a stable haploid genome of 29.4 million base pairs . (wikipedia.org)
  • Large-scale genome comparisons have shown that no gene sets are shared exclusively by both Aspergillus fumigatus and any other human pathogen sequenced to date, such as Candida or Cryptococcus species. (nih.gov)
  • Like most major genome projects, these Aspergillus efforts were collaborations between a large sequencing centre and the respective community of scientists. (kenyon.edu)
  • The Institute for Genome Research (TIGR) worked with the Aspergillus fumigatus community. (kenyon.edu)
  • A repeated DNA sequence used for epidemiological studies of the human opportunistic pathogen Aspergillus fumigatus has been characterized. (nih.gov)
  • This does not happen if the pathogen Aspergillus fumigatus is involved. (news-medical.net)
  • Here, we examined the importance of protein farnesylation in the opportunistic fungal pathogen Aspergillus fumigatus through generation of a mutant lacking the farnesyltransferase β-subunit, ramA. (aspergillus.org.uk)
  • 4 In a large U.S. study, antifungal resistance was identified in up to 7% of Aspergillus specimens from patients with stem cell and organ transplants. (cdc.gov)
  • Aspergillus fumigatus has widely evolved resistance to the most commonly used class of antifungal chemicals, the azoles. (asm.org)
  • Azole resistance in Aspergillus: an emerging problem? (nih.gov)
  • Reports of Aspergillus' azole resistance are emerging, and resistance is now recognised as a cause of treatment failure. (nih.gov)
  • The scope of this article is to describe the problem of resistance in Aspergillus: the epidemiology, clinical impact and the underlying molecular mechanisms. (nih.gov)
  • As environmental pan-azole resistance of Aspergillus fumigatus is reported in increasing numbers in the Netherlands, surveillance is warranted. (nih.gov)
  • which is non-susceptible to Amphotericin B. Knowledge about epidemiology on Aspergillus susceptibility patterns represents a corner stone for appropriate antifungal prophylaxis and treatment as in areas with high rates of environmental azole resistance primarily antifungal treatment with azoles may be reconsidered. (frontiersin.org)
  • Evaluation of Cyp51A mechanisms of azole resistance in Aspergillus fumigatus isolates from the United States. (thefreedictionary.com)
  • The Fungiplex ® Aspergillus Azole-R PCR IVD Kit is a real-time PCR test which identifies the most common mutations of the Cyp51 gene associated with resistance to the azole class of antifungal drugs. (bruker.com)
  • Resistance in Aspergillus fumigatus is caused by known mutations of the Cyp51 gene that threaten the role of the azole class of antifungals. (bruker.com)
  • The Fungiplex ® Aspergillus Azole-R PCR IVD Kit can be used alongside Fungiplex Aspergillus for an early indication of azole resistance in high risk patients, or in patient samples testing positive for Aspergillus with the Fungiplex Aspergillus PCR. (bruker.com)
  • The Fungiplex ® Aspergillus Azole-R PCR IVD Kit provides results in under 2 hours from extracted DNA, allowing rapid identification of patients with invasive A. fumigatus carrying a mutation for azole resistance. (bruker.com)
  • Aspergillus is second only to Candida in the frequency of opportunistic mycosis among immunocompromised hosts. (scielo.br)
  • citation needed] In addition to growth on carbon sources, many species of Aspergillus demonstrate oligotrophy where they are capable of growing in nutrient-depleted environments, or environments with a complete lack of key nutrients. (wikipedia.org)
  • Species of Aspergillus are important medically and commercially. (wikipedia.org)
  • In "Genetics and Physiology of Aspergillus ", J.E. Smith and J.A. Pateman, eds. (springer.com)
  • Aspergillus home page at the Fungal Genetics Stock Center ( FGSC ). (aspergillus.org.uk)
  • The Platelia(r) Aspergillus EIA kit was evaluated for sensitivity (52.9% and 79.3%) and specificity (87.0% and 88.8%) in the multicenter US study that led to its FDA clearance of serum for pediatric and adult patients, respectively. (akronchildrens.org)
  • Systematics of Aspergillus species of subgenus Nidulantes in Iran - Scientific Figure on ResearchGate. (kenyon.edu)
  • The research article, Phylogeny of xerophilic aspergilli (subgenus Aspergillus) and taxonomic revision of section Restricti, was published in the September 2017 issue of Studies in Mycology. (webwire.com)
  • Solomon W.R., Burge H.P. and Boise, J.P. (1978) Airborne Aspergillus fiimigatus levels outside and within a large clinical center. (springer.com)
  • Two or more consecutive positive results should be obtained from separately drawn specimens before the patient is considered to have a positive Aspergillus antigen test. (akronchildrens.org)
  • Among other factors, it is gliotoxin - a potent mycotoxin - that is responsible for the pathogenicity of Aspergillus fumigatus. (news-medical.net)
  • In conclusion, this study shows that Aspergillus is a producing agent for p53 and Aspergillus pathogenicity is caused by production of p53. (scirp.org)
  • Aspergillus section Restricti along with sister section Aspergillus (formerly Eurotium ) comprises xerophilic species, which are able to grow on substrates with low water activity and in extreme environments. (webwire.com)
  • Aspergillus fumigatus grown on certain building materials can produce genotoxic and cytotoxic mycotoxins , such as gliotoxin . (wikipedia.org)
  • El equipo de investigación de la universidad de Jena (Alemania) clarifica el mecanismo del gliotoxin, una micotoxina del fumigatus fungoso del aspergillus. (news-medical.net)
  • Entre otros factores, es gliotoxin - una micotoxina potente - que es responsable de la patogenicidad del fumigatus del aspergillus. (news-medical.net)
  • Para lograr esto, los investigadores trajeron las células inmunes en contacto con el gliotoxin sintetizadamente producido. (news-medical.net)
  • Pues los científicos de Jena podían mostrar, el gliotoxin se asegura de que la producción de la substancia leukotrieneB4 del mensajero en los granulocytes neutrophilic esté inhibida, de modo que no puedan enviar una señal a otras células inmunes. (news-medical.net)
  • What is the role of aspergillus precipitins and serum total IgE levels in the diagnosis of bronchiectasis? (medscape.com)
  • Aspergillus precipitins and serum total IgE levels are important in making the diagnosis of ABPA. (medscape.com)
  • Developmental repression of growth and gene expression in Aspergillus. (pnas.org)
  • Aspergillus fumigatus was isolated on fungal culture, and species identity was confirmed using comparative sequence analysis of the partial β-tubulin gene. (aspergillus.org.uk)
  • Bruker's Fungiplex ® Aspergillus Azole-R PCR IVD Kit assay is a real-time PCR designed to detect the presence of these TR 34 and TR46 mutations in the Cyp51 gene of A. fumigatus. (bruker.com)
  • 5 Aspergillus mold can also grow on ceiling and walls where water damage has occurred. (labcorp.com)
  • This is the first outcome from the large-scale sequencing of 300+ Aspergillus species," said study co-author Igor Grigoriev, head of the JGI Fungal Genomics Program. (infectioncontroltoday.com)
  • Mullins J. (1994) Aspergillus and Aerobiology. (springer.com)
  • What is an aspergillus precipitin test? (healthline.com)
  • Aspergillus precipitin is a laboratory test performed on your blood. (healthline.com)
  • Aspergillus precipitin test results are usually available within one to two days. (healthline.com)