Aspergillus: A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.Aspergillus fumigatus: A species of imperfect fungi from which the antibiotic fumigatin is obtained. Its spores may cause respiratory infection in birds and mammals.Aspergillus nidulans: A species of imperfect fungi from which the antibiotic nidulin is obtained. Its teleomorph is Emericella nidulans.Aspergillus niger: An imperfect fungus causing smut or black mold of several fruits, vegetables, etc.Aspergillus flavus: A species of imperfect fungi which grows on peanuts and other plants and produces the carcinogenic substance aflatoxin. It is also used in the production of the antibiotic flavicin.Aspergillosis: Infections with fungi of the genus ASPERGILLUS.Spores, Fungal: Reproductive bodies produced by fungi.Aflatoxins: Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.Aspergillus ochraceus: An imperfect fungus that produces ochratoxins and contaminates EDIBLE GRAIN and coffee beans.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Fungal Proteins: Proteins found in any species of fungus.Pulmonary Aspergillosis: Infections of the respiratory tract with fungi of the genus ASPERGILLUS. Infections may result in allergic reaction (ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS), colonization in pulmonary cavities as fungus balls (MYCETOMA), or lead to invasion of the lung parenchyma (INVASIVE PULMONARY ASPERGILLOSIS).Sterigmatocystin: A carcinogenic mycotoxin produced in high yields by strains of the common molds, Aspergillus versicolor, A. nidulans, and an unidentified species of Bipolaris. It causes necrosis of the liver and kidney and has an inhibitory effect on orotic acid incorporation into nuclear RNA.Aspergillosis, Allergic Bronchopulmonary: Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.DNA, Fungal: Deoxyribonucleic acid that makes up the genetic material of fungi.Glucan 1,4-alpha-Glucosidase: An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.Lung Diseases, Fungal: Pulmonary diseases caused by fungal infections, usually through hematogenous spread.Hyphae: Microscopic threadlike filaments in FUNGI that are filled with a layer of protoplasm. Collectively, the hyphae make up the MYCELIUM.Genes, Fungal: The functional hereditary units of FUNGI.Fungi: A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.Invasive Pulmonary Aspergillosis: Lung infections with the invasive forms of ASPERGILLUS, usually after surgery, transplantation, prolonged NEUTROPENIA or treatment with high-doses of CORTICOSTEROIDS. Invasive pulmonary aspergillosis can progress to CHRONIC NECROTIZING PULMONARY ASPERGILLOSIS or hematogenous spread to other organs.Gene Expression Regulation, Fungal: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.Penicillium: A mitosporic Trichocomaceae fungal genus that develops fruiting organs resembling a broom. When identified, teleomorphs include EUPENICILLIUM and TALAROMYCES. Several species (but especially PENICILLIUM CHRYSOGENUM) are sources of the antibiotic penicillin.TriazolesAntigens, Fungal: Substances of fungal origin that have antigenic activity.Ochratoxins: Isocoumarins found in ASPERGILLUS OCHRACEUS and other FUNGI. Ochratoxin contaminated FOOD has been responsible for cases of FOODBORNE DISEASES.Drug Resistance, Fungal: The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.Gliotoxin: A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.Mycotoxins: Toxic compounds produced by FUNGI.Mannans: Polysaccharides consisting of mannose units.Echinocandins: Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Mycology: The study of the structure, growth, function, genetics, and reproduction of fungi, and MYCOSES.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.MycosesMycelium: The body of a fungus which is made up of HYPHAE.Neuroaspergillosis: Infections of the nervous system caused by fungi of the genus ASPERGILLUS, most commonly ASPERGILLUS FUMIGATUS. Aspergillus infections may occur in immunocompetent hosts, but are more prevalent in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES. The organism may spread to the nervous system from focal infections in the lung, mastoid region, sinuses, inner ear, bones, eyes, gastrointestinal tract, and heart. Sinus infections may be locally invasive and enter the intracranial compartment, producing MENINGITIS, FUNGAL; cranial neuropathies; and abscesses in the frontal lobes of the brain. (From Joynt, Clinical Neurology, 1998, Ch 27, pp62-3)Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Fusarium: A mitosporic Hypocreales fungal genus, various species of which are important parasitic pathogens of plants and a variety of vertebrates. Teleomorphs include GIBBERELLA.Antibodies, Fungal: Immunoglobulins produced in a response to FUNGAL ANTIGENS.Air Microbiology: The presence of bacteria, viruses, and fungi in the air. This term is not restricted to pathogenic organisms.Mycological Typing Techniques: Procedures for identifying types and strains of fungi.Arachis hypogaea: A plant species of the family FABACEAE that yields edible seeds, the familiar peanuts, which contain protein, oil and lectins.Mitosporic Fungi: A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.Fermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Benomyl: A systemic agricultural fungicide used for control of certain fungal diseases of stone fruit.Eye Infections, Fungal: Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.Reproduction, Asexual: Reproduction without fusion of two types of cells, mostly found in ALGAE; FUNGI; and PLANTS. Asexual reproduction occurs in several ways, such as budding, fission, or splitting from "parent" cells. Only few groups of ANIMALS reproduce asexually or unisexually (PARTHENOGENESIS).6-Phytase: An enzyme that catalyzes the conversion of myo-inositol hexakisphosphate and water to 1L-myo-inositol 1,2,3,4,5-pentakisphosphate and orthophosphate. EC 3.1.3.26.Azoles: Five membered rings containing a NITROGEN atom.Transformation, Genetic: Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Genome, Fungal: The complete gene complement contained in a set of chromosomes in a fungus.Pyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.Polygalacturonase: A cell wall-degrading enzyme found in microorganisms and higher plants. It catalyzes the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. EC 3.2.1.15.Anthraquinones: Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.Immunocompromised Host: A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Glycoside HydrolasesCell Wall: The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.Peptides, Cyclic: Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Gene Deletion: A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.Xylosidases: A group of enzymes that catalyze the hydrolysis of alpha- or beta-xylosidic linkages. EC 3.2.1.8 catalyzes the endo-hydrolysis of 1,4-beta-D-xylosidic linkages; EC 3.2.1.32 catalyzes the endo-hydrolysis of 1,3-beta-D-xylosidic linkages; EC 3.2.1.37 catalyzes the exo-hydrolysis of 1,4-beta-D-linkages from the non-reducing termini of xylans; and EC 3.2.1.72 catalyzes the exo-hydrolysis of 1,3-beta-D-linkages from the non-reducing termini of xylans. Other xylosidases have been identified that catalyze the hydrolysis of alpha-xylosidic bonds.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Rhizopus: A genus of zygomycetous fungi of the family Mucoraceae, order MUCORALES, a common saprophyte and facultative parasite of mature fruits and vegetables. It may cause cerebral mycoses in diabetes and cutaneous infection in severely burned patients.Drug Resistance, Multiple, Fungal: The ability of fungi to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance phenotype may be attributed to multiple gene mutations.Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.beta-Glucans: Glucose polymers consisting of a backbone of beta(1->3)-linked beta-D-glucopyranosyl units with beta(1->6) linked side chains of various lengths. They are a major component of the CELL WALL of organisms and of soluble DIETARY FIBER.Eurotiales: An order of fungi in the phylum ASCOMYCOTA characterized by the presence of well defined peridia and cleistothecial asci. Notable anamorphs (mitosporic forms) of Eurotiales include PENICILLIUM and ASPERGILLUS.Candida: A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)Neosartorya: A genus of ascomycetous fungi in the family Trichocomaceae, order EUROTIALES. Some species can cause opportunistic infections in humans, similar to its anamorph ASPERGILLUS.Emericella: A genus in the family Trichocomaceae, order EUROTIALES. The anamorph is ASPERGILLUS.Aflatoxin B1: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Food Microbiology: The presence of bacteria, viruses, and fungi in food and food products. This term is not restricted to pathogenic organisms: the presence of various non-pathogenic bacteria and fungi in cheeses and wines, for example, is included in this concept.Lipopeptides: Compounds consisting of a short peptide chain conjugated with an acyl chain.Xylans: Polysaccharides consisting of xylose units.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Industrial Microbiology: The study, utilization, and manipulation of those microorganisms capable of economically producing desirable substances or changes in substances, and the control of undesirable microorganisms.Isomaltose: A disaccharide consisting of two glucose units in an alpha (1-6) glycosidic linkage.Chromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.DNA, Ribosomal Spacer: The intergenic DNA segments that are between the ribosomal RNA genes (internal transcribed spacers) and between the tandemly repeated units of rDNA (external transcribed spacers and nontranscribed spacers).Chitin: A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. It is the second most abundant biopolymer on earth, found especially in INSECTS and FUNGI. When deacetylated it is called CHITOSAN.Biosynthetic Pathways: Sets of enzymatic reactions occurring in organisms and that form biochemicals by making new covalent bonds.Ergot Alkaloids: Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists.alpha-Amylases: Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.RNA, Fungal: Ribonucleic acid in fungi having regulatory and catalytic roles as well as involvement in protein synthesis.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Penicillium chrysogenum: A mitosporic fungal species used in the production of penicillin.beta-Glucosidase: An exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of GLUCOSE.XyloseCladosporium: A mitosporic Loculoascomycetes fungal genus including some economically important plant parasites. Teleomorphs include Mycosphaerella and Venturia.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Enzyme Stability: The extent to which an enzyme retains its structural conformation or its activity when subjected to storage, isolation, and purification or various other physical or chemical manipulations, including proteolytic enzymes and heat.Cellulase: An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, lichenin, and cereal beta-glucans.Granulomatous Disease, Chronic: A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Food Contamination: The presence in food of harmful, unpalatable, or otherwise objectionable foreign substances, e.g. chemicals, microorganisms or diluents, before, during, or after processing or storage.Fusariosis: OPPORTUNISTIC INFECTIONS with the soil fungus FUSARIUM. Typically the infection is limited to the nail plate (ONYCHOMYCOSIS). The infection can however become systemic especially in an IMMUNOCOMPROMISED HOST (e.g., NEUTROPENIA) and results in cutaneous and subcutaneous lesions, fever, KERATITIS, and pulmonary infections.Scedosporium: A mitosporic fungal genus previously called Monosporium. Teleomorphs include PSEUDALLESCHERIA.Carboxylic Ester Hydrolases: Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.PolysaccharidesChitin Synthase: An enzyme that converts UDP glucosamine into chitin and UDP. EC 2.4.1.16.Endo-1,4-beta Xylanases: Enzymes which catalyze the endohydrolysis of 1,4-beta-D-xylosidic linkages in XYLANS.

Thaumatin production in Aspergillus awamori by use of expression cassettes with strong fungal promoters and high gene dosage. (1/1936)

Four expression cassettes containing strong fungal promoters, a signal sequence for protein translocation, a KEX protease cleavage site, and a synthetic gene (tha) encoding the sweet protein thaumatin II were used to overexpress this protein in Aspergillus awamori lpr66, a PepA protease-deficient strain. The best expression results were obtained with the gdhA promoter of A. awamori or with the gpdA promoter of Aspergillus nidulans. There was good correlation of tha gene dosage, transcript levels, and thaumatin secretion. The thaumatin gene was expressed as a transcript of the expected size in each construction (1.9 or 1.4 kb), and the transcript levels and thaumatin production rate decayed at the end of the growth phase, except in the double transformant TB2b1-44-GD5, in which secretion of thaumatin continued until 96 h. The recombinant thaumatin secreted by a high-production transformant was purified to homogeneity, giving one major component and two minor components. In all cases, cleavage of the fused protein occurred at the KEX recognition sequence. This work provides new expression systems in A. awamori that result in very high levels of thaumatin production.  (+info)

Identification and characterization of genes required for hyphal morphogenesis in the filamentous fungus Aspergillus nidulans. (2/1936)

In the filamentous fungus Aspergillus nidulans, germination of an asexual conidiospore results in the formation of a hyphal cell. A key feature of spore germination is the switch from isotropic spore expansion to polarized apical growth. Here, temperature-sensitive mutations are used to characterize the roles of five genes (sepA, hypA, podB-podD) in the establishment and maintenance of hyphal polarity. Evidence that suggests that the hypA, podB, and sepA genes are required for multiple aspects of hyphal morphogenesis is presented. Notably, podB and sepA are needed for organization of the cytoskeleton at sites of polarized growth. In contrast, podC and podD encode proteins that appear to be specifically required for the establishment of hyphal polarity during spore germination. The role of sepA and the pod genes in controlling the spatial pattern of polarized morphogenesis in germinating spores is also described. Results obtained from these experiments indicate that the normal pattern of germ-tube emergence is dependent upon the integrity of the actin cytoskeleton.  (+info)

Cloning and expression of a cDNA encoding the laccase from Schizophyllum commune. (3/1936)

We cloned and analyzed the nucleotide sequence of a cDNA that encodes polyphenol oxidase (laccase) from the white-rot basidiomycete Schizophyllum commune. The nucleotide sequence of the full-length cDNA contained a 1554-base open reading frame that encoded a polypeptide of 518 amino acid residues, including a putative signal peptide of 16 residues. It contained four highly similar regions that are conserved in the deduced amino acid sequences of other laccases, including the region thought to be involved in copper binding. Aspergillus sojae strain 1860 (which has low protease levels) was transformed with the plasmid lacAL/pTPT, which contained the laccase gene under the control of the tannase promoter from Aspergillus oryzae. Laccase was secreted into the medium when transformants A1 and A2 were cultured in tannic acid-containing medium.  (+info)

Purification and characterization of Aspergillus ficuum endoinulinase. (4/1936)

Endoinulinase from Aspergillus ficuum, which catalyzes the hydrolysis of inulin via an endo-cleavage mode, was purified by chromatography from Novozym 230 as a starting commercial enzyme mixture on CM-Sephadex and DEAE-Sepharose, and by preparative electrophoresis under native conditions. The enzyme was estimated to be pure on the basis of its I/S ratio, whose value was infinite in our assay conditions. Two forms separated by using this method. SDS gel electrophoresis showed the two purified forms to respectively exhibit molecular weights of 64,000 +/- 500 and 66,000 +/- 1,000. The results of deglycosylation indicated that the two forms were originally the same protein but with different sugar contents. A molecular weight of 54,800 +/- 1,500 was found by gel filtration of the native enzyme, indicating the native functional protein to be a monomer. The enzyme showed nearly absolute substrate specificity towards inulin and inulooligosaccharides, and acted via an endo-attack to produce mainly inulotriose during the late stage of the reaction. The apparent Km and Vmax values for inulin hydrolysis were 8.1 +/- 1.0 mM and 773 +/- 60 U/mg, respectively. The internal peptides of the enzyme showed sequence homology to the endoinulinase of Penicillium purpurogenum.  (+info)

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. (5/1936)

In mammals, the Rho family GTPase Rac2 is restricted in expression to hematopoietic cells, where it is coexpressed with Rac1. Rac2-deficient mice were created to define the physiological requirement for two near-identical Rac proteins in hematopoietic cells. rac2-/- neutrophils displayed significant defects in chemotaxis, in shear-dependent L-selectin-mediated capture on the endothelial substrate Glycam-1, and in both F-actin generation and p38 and, unexpectedly, p42/p44 MAP kinase activation induced by chemoattractants. Superoxide production by rac2-/- bone marrow neutrophils was significantly reduced compared to wild type, but it was normal in activated peritoneal exudate neutrophils. These defects were reflected in vivo by baseline neutrophilia, reduced inflammatory peritoneal exudate formation, and increased mortality when challenged with Aspergillus fumigatus. Rac2 is an essential regulator of multiple specialized neutrophil functions.  (+info)

Production of specific monoclonal antibodies to Aspergillus species and their use in immunohistochemical identification of aspergillosis. (6/1936)

Two anti-Aspergillus murine monoclonal antibodies (MAbs), designated 164G and 611F, have been produced; both specifically recognize cytoplasmic antigens of A. fumigatus, A. flavus, and A. niger by enzyme-linked immunosorbent assay. The MAbs can identify Aspergillus spp. both in frozen sections by immunofluorescence and in paraffin-embedded clinical specimens by immunofluorescence and immunoperoxidase staining.  (+info)

Effect of zinc on adenine nucleotide pools in relation to aflatoxin biosynthesis in Aspergillus parasiticus. (7/1936)

The adenylic acid systems of Aspergillus parasiticus were studied in zinc-replete and zinc-deficient media. The adenosine 5'-triphosphate levels of the fungus were high during exponential phase and low during stationary phase in zinc-replete cultures. On the other hand, the levels of adenosine 5'-diphosphate and adenosine 5'-monophosphate were low during exponential phase of growth and high during stationary phase. The adenosine 5'-triphosphate levels during exponential phase may indicate higher primary metabolic activity of the fungus. On the other hand, high adenosine 5'-monophosphate levels during stationary phase may inhibit lipid formation and may enhance aflatoxin levels. The inorganic phosphorus content was low in a zinc-replete medium throughout the growth period, thereby favoring aflatoxin biosynthesis. The energy charge during the exponential phase was high but low during the stationary phase. In general the energy charge values were lower because of high adenosine 5'-monophosphate content.  (+info)

Characterization of the promoter for the gene encoding the aflatoxin biosynthetic pathway regulatory protein AFLR. (8/1936)

Most genes in the aflatoxin biosynthetic pathway in Aspergillus parasiticus are regulated by the binuclear zinc cluster DNA-binding protein AFLR. The aflR promoter was analyzed in beta-glucuronidase reporter assays to elucidate some of the elements involved in the gene's transcription control. Truncation at 118 bp upstream of the translational start site increased promoter activity 5-fold, while truncation at -100 reduced activity about 20-fold. These findings indicate the presence of an important positive regulatory element between -100 and -118 and a negative regulatory region further upstream. Electrophoretic mobility shift assays on nuclear extracts from A. parasiticus induced for aflatoxin expression suggest that AFLR and another, possibly more abundant, protein bind to the -100/-118 region. Another protein binds to a sequence at position -159 to -164 that matches the consensus binding site for the transcription factor involved in pH-dependent gene regulation, PACC.  (+info)

*Aspergillus

... consists of a few hundred species. Aspergillus is defined as a group of conidial fungi-that is, fungi in an asexual ... Aspergillus are found in millions in pillows. Species of Aspergillus are important medically and commercially. Some species can ... US 6069146 "GRAS Notification for Acid Lactase from Aspergillus oryzae Expressed in Aspergillus niger". Section 2. Wortman; ... doctors and scientists Aspergillus surveillance project at a large tertiary-care hospital. (PDF). The Aspergillus Genome ...

*Aspergillus qinqixianii

... is a species of the genus of Aspergillus which has been isolated from desert soil from the Taklimakan ... List of Aspergillus species "Aspergillus qinqixianii". www.mycobank.org. Chen, A.J.; Frisvad, J.C.; Sun, B.D.; Varga, J.; ... "Aspergillus qinqixianii". www.uniprot.org. Horie, Yoshikazu; Abliz, Paride; Hui, Yan; Fukiharu, Toshimitsu; Nishimura, Kazuko; ... Aspergillus qinqixianii produces asteltoxin, asperthecin, emericellin, 2-ω-hydroxyemodin, shamixanthones, terrein, curvularin ...

*Aspergillus pulvericola

... is a species of the genus of Aspergillus which produces ochratoxin A. List of Aspergillus species " ... "Aspergillus pulvericola". www.cbs.knaw.nl. "Aspergillus pulvericola". www.uniprot.org. Visagie, C.M.; Varga, J.; Houbraken, J ... Aspergillus section Circumdati)". Studies in Mycology. 78: 1-61. doi:10.1016/j.simyco.2014.07.001. ...

*Aspergillus carlsbadensis

List of Aspergillus species "Aspergillus carlsbadensis". www.uniprot.org. "Aspergillus carlsbadensis". www.mycobank.org. Samson ... Aspergillus carlsbadensis is a species of the genus of Aspergillus which has been isolated from the Carlsbad Caverns National ... "Aspergillus carlsbadensis Frisvad, Varga & Samson sp. nov. A-C.... - Figure 4 of 9". ResearchGate. ... R.A.; Varga, J.; Meijer, M.; Frisvad, J.C. (June 2011). "New taxa in Aspergillus section Usti". Studies in Mycology. 69: 81-97 ...

*Aspergillus keveii

... is a species of the genus of Aspergillus which has been isolated from soil from Las Palmas in Spain. List of ... "Aspergillus keveii". Www.uniprot.org. Samson, Robert A.; Varga, János (2017). Aspergillus Systematics in the Genomic Era. CBS ... Houbraken, J.; Due, M.; Varga, J.; Meijer, M.; Frisvad, J.C.; Samson, R.A. (2007). "Polyphasic taxonomy of Aspergillus section ... Houbraken, J.; Due, M.; Varga, J.; Meijer, M.; Frisvad, J.C.; Samson, R.A. (2007). "Polyphasic taxonomy of Aspergillus section ...

*Aspergillus panamensis

... is a species of the genus of Aspergillus which produces cyclogregatin, gregatin A, gregatin B, gregatin ... "Aspergillus panamensis". www.uniprot.org. ANKE, H.; SCHWAB, H.; ACHENBACH, H. (1980). "Tetronic acid derivatives from ... Anke, H; Casser, I; Schrage, M; Steglich, W (November 1988). "Cyclogregatin, a new metabolite from Aspergillus panamensis". The ... ISBN 0-851-86662-X. ANKE, H.; SCHWAB, H.; ACHENBACH, H. (1980). "Tetronic acid derivatives from Aspergillus panamensis. ...

*Aspergillus versicolor

"Aspergillus versicolor". MycoBank. Retrieved 17 October 2013. "Aspergillus versicolor". Doctor Fungus. Retrieved 17 October ... Like other Aspergillus species, A. versicolor is an eye, nose, and throat irritant. The fungus was first described by Jean-Paul ... Aspergillus versicolor is able to grow on a variety of surfaces, including those that are nutrient-deficient, because it is ... Aspergillus versicolor is a slow-growing filamentous fungus commonly found in damp indoor environments and on food products. It ...

*Aspergillus acidus

... is a species of the genus of Aspergillus. Aspergillus acidus can be used in food fermentation for tea. List ... ISBN 0-444-63513-0. Mogensen, J.M.; Varga, J.; Thrane, U.; Frisvad, J.C. (June 2009). "Aspergillus acidus from Puerh tea and ... ISBN 3-319-25277-1. "Aspergillus acidus". Www.uniprot.org. Jyoti Prakash, Tamang (2015). Health Benefits of Fermented Foods and ... of Aspergillus species http://www.mycobank.org Neelam, Garg; Shadia Mohammad, Abdel-Aziz; Abhinav, Aeron (2016). Microbes in ...

*Aspergillus unguis

... is a member of the genus Aspergillus in the phylum Ascomycota, and the asexual state (anamorph) of ... Raper1 Fennell2, K.B.1, D.I.2 (1965). The Genus Aspergillus. Williams and Wilkins. p. 686. "Aspergillus unguis". www.mycobank. ... Aspergillus laokiashanensis and Aspergillus mellinus. Colonies typically reach up to 2 cm in diameter at 10 days incubation, ... Aspergillus unguis is a soil-dwelling fungus that prefers high water activity (aw). Disease of the nail and skin caused by A. ...

*Aspergillus lentulus

... is a species of Aspergillus fungus. It is a close relative of Aspergillus fumigatus. It has smaller ... Aspergillus lentulus is an opportunistic human pathogen that causes invasive aspergillosis with high mortality rates. It has ... Swilaiman SS, O'Gorman CM, Balajee SA, Dyer PS (July 2013). "Discovery of a sexual cycle in Aspergillus lentulus, a close ... Balajee, S. Arunmozhi; Jennifer L. Gribskov; Edward Hanley; David Nickle; Kieren A. Marr (2005). "Aspergillus lentulus sp. nov ...

*Aspergillus felis

Aspergillus acidus is a heterothallic species of the genus of Aspergillus which can cause aspergillosis in humans, dogs and ... List of Aspergillus species "Aspergillus felis". www.uniprot.org. www.mycobank.org Barrs, Vanessa R.; van Doorn, Tineke M.; ... "Aspergillus felis: new fungus found in Australia, causes infections in humans, cats , Aspergillus & Aspergillosis Website". www ... "Aspergillus felis sp. nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs". PLoS ONE. 8 (6): e64871. ...

*Aspergillus brunneoviolaceus

... is a species of the genus of Aspergillus. List of Aspergillus species "Aspergillus ... "A. brunneoviolaceus , Aspergillus & Aspergillosis Website". www.aspergillus.org.uk. "Aspergillus brunneoviolaceus". www.uniprot ... "Home - Aspergillus brunneoviolaceus CBS 621.78 v1.0". genome.jgi.doe.gov. "Fig. 3. Aspergillus brunneoviolaceus (syn. A. ... "Two novel species of Aspergillus section Nigri from indoor air". IMA Fungus. 3 (2): 159-173. doi:10.5598/imafungus.2012.03. ...

*Aspergillus ustus

A sugarcane farm in Egypt was found to host A. ustus and other species of Aspergillus section Usti. Aspergillus ustus is ... Novakova, A.; Hubka, V.; Saiz-Jimenez, C.; Kolarik, M. (13 April 2012). "Aspergillus baeticus sp. nov. and Aspergillus ... Aspergillus ustus has been found on the surfaces of walls of caves and in indoor air of buildings including hospitals, soils ... Aspergillus ustus is a microfungus and member of the division Ascomycota. It is commonly found in indoor environments and soil ...

*Aspergillus candidus

... is a member of the genus Aspergillus in the family Trichocomaceae, phylum Ascomycota. A number of ... Aspergillus candidus is a white-spored species of Aspergillus (family Trichocomaceae, order Eurotiales, phylum Ascomycota). ... Aspergillus candidus has been associated with a variety of diseases such as hypersensitivity diseases, and infectious diseases ... Aspergillus candidus secretes cytotoxic metabolites like terphenyl compounds and terprenins, as well as citrinin and ...

*Aspergillus oerlinghausenensis

... is an anamorph species of the genus of Aspergillus which has been isolated from soil in Germany ... List of Aspergillus species "Aspergillus oerlinghausenensis". www.uniprot.org. Houbraken, Jos; Weig, Michael; Groß, Uwe; Meijer ... "A. oerlinghausenensis , Aspergillus & Aspergillosis Website". www.aspergillus.org.uk. ... Martin; Bader, Oliver; Poeggeler, Stefanie (February 2016). "Aspergillus oerlinghausenensis, a new mould species closely ...

*Aspergillus haitiensis

... is a species of the genus of Aspergillus which has been isolated from soil under cactus and sage. List ... "Aspergillus haitiensis (CBS 464.91). A-C. Colonies of , Open-i". openi.nlm.nih.gov. ... Varga, János; Frisvad, Jens C.; Samson, Robert A. (4 April 2017). "Polyphasic taxonomy of Aspergillus section Sparsi". IMA ... of Aspergillus species "Aspergillus haitiensis". www.uniprot.org. ...

*Aspergillus dybowskii

... is a species of the genus of Aspergillus which occurs in Southeast Asia. List of Aspergillus species "www ... "A. dybowskii , Aspergillus & Aspergillosis Website". www.aspergillus.org.uk. Contributions Toward a Mycobiota of Indonesia: ... Samson, Robert (2013). Advances in Penicillium and Aspergillus Systematics. Springer Science & Business Media. ISBN ... Integration of Modern Taxonomic Methods For Penicillium and Aspergillus Classification. CRC Press. ISBN 9789058231598. " ...

*Aspergillus foetidus

... is a species of fungus in the family Trichocomaceae. "Aspergillus foetidus Thom & Raper 1945". MycoBank. ...

*Aspergillus zonatus

... produces azonalenin and aszonapyrone A List of Aspergillus species "www.mycobank.org". "Aspergillus zonatus ... Aspergillus zonatus is a species of the genus of Aspergillus which has been isolated from forest soil in Costa Rica. ... ISBN 0-080-52702-7. CS1 maint: Extra text: authors list (link) "Home - Aspergillus zonatus v1.0". genome.jgi.doe.gov. ... by Robert A.; Pitt, John I. (2000). Integration of modern taxonomic methods for penicillium and aspergillus classification. ...

*Aspergillus marvanovae

List of Aspergillus species "Aspergillus marvanovae". Www.mycobank.org. "Aspergillus marvanovae". Www.uniprot.org. Hubka, V.; ... Aspergillus marvanovae is a species of the genus of Aspergillus which has been isolated from water with high boracic acid ... and Aspergillus marvanovae sp. nov., two closely related species in section Fumigati". International Journal of Systematic and ... Frederic, Lamoth; William J., Steinbach (2016). Advances in Aspergillus fumigatus pathobiology. Frontiers Media SA. ISBN 2-889- ...

*Aspergillus carneus

... is a species of the genus of Aspergillus.Aspergillus carneus produces Aspergillicin A - E and citrinin List ... "A. carneus , Aspergillus & Aspergillosis Website". www.aspergillus.org.uk. "Aspergillus carneus". www.uniprot.org. Blunt, John ... Machida, Masayuki; Gomi, Katsuya (2010). Aspergillus: Molecular Biology and Genomics. Horizon Scientific Press. ISBN ... of Aspergillus species "Aspergillus carneus". www.mycobank.org. " ...

*Aspergillus flavus

p. 924 Aspergillus flavus Genome Sequencing Project Aspergillus flavus research. ... Aspergillus flavus is a saprotrophic and pathogenic fungus with a cosmopolitan distribution. It is best known for its ... After Aspergillus fumigatus, A. flavus is the second-leading cause of aspergillosis. Primary infection is caused by the ... "Aspergillus flavus". Center for Integrated Fungal Research. Center for Integrated Fungal Research. "Helpful Yeast Battles Food- ...

*Aspergillus rambellii

"Phylogeny and subgeneric taxonomy of Aspergillus". In Varga, János; Samson, Robert A. Aspergillus in the Genomic Era. ... Aspergillus rambellii is a species of fungus in the family Trichocomaceae. It accumulates very large amounts of ... Aspergillus: Molecular Biology and Genomics. Horizon Scientific Press. pp. 19-40. ISBN 978-1-904455-53-0. Peterson, Stephen W ... Samson, Robert A.; Varga, János (2010). "2. Molecular Systematics of Aspergillus and its Teleomorphs". In Masayuki Machida; ...

*Aspergillus microcysticus

... is a species of the genus of Aspergillus. Aspergillus microcysticus produces aspochalasin A, ... List of Aspergillus species "Aspergillus microcysticus". www.mycobank.org. Samson, ed. by Robert A.; Pitt, John I. (2000). ... "Aspergillus". www.uniprot.org. Heberle, Wolfgang (1 January 1974). "Asposterol, ein antibiotikum aus aspergillus microcysticus ... ISBN 0-851-86652-2. Samson, R.A.; Peterson, S.W.; Frisvad, J.C.; Varga, J. (June 2011). "New species in Aspergillus section ...

*Aspergillus waksmanii

... produces apolar indoloterpenes. List of Aspergillus species "Aspergillus waksmanii". www.uniprot.org. " ... Aspergillus waksmanii is a homothallic species of the genus of Aspergillus which has been isolated from soil from New Jersey in ... "Aspergillus waksmanii sp. nov. and Aspergillus marvanovae sp. nov., two closely related species in section Fumigati". ... Frederic, Lamoth; William J., Steinbach (2016). Advances in Aspergillus fumigatus pathobiology. Frontiers Media SA. ISBN 2-889- ...
Aspergillus tubingensis XghA protein: pectinolytic enzyme from Aspergillus tubingensis; amino acid sequence in first source; GenBank AJ249460
Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester connected by peptide bonds. These new compounds exhibited pharmacological activity by improving insulin sensitivity, which was evaluated in an adipogenesis model using human bone marrow mesenchymal stem cells. In addition, the compounds exhibited fluorescence changes upon binding to DNA, demonstrating their potential applications to DNA sequence recognition.
Preferred for the invention is CBMs of Carbohydrate-Binding Module Family 20. CBMs of Carbohydrate-Binding Module Family 20 suitable for the invention may be derived from glucoamylases of Aspergillus awamori (SWISSPROT Q12537), Aspergillus kawachii (SWISSPROT P23176), Aspergillus niger (SWISSPROT P04064), Aspergillus oryzae (SWISSPROT P36914), from alpha-amylases of Aspergillus kawachii (EMBL#AB008370), Aspergillus nidulans (NCBI AAF17100.1), from beta-amylases of Bacillus cereus (SWISSPROT P36924), or from CGTases of Bacillus circulans (SWISSPROT P43379). Preferred is a CBM from the alpha-amyiase of Aspergillus kawachii (EMBL:#AB008370) as well as CBMs having at least 50%, 60%, 70%, 80% or even at least 90% homology to the CBM of the alpha-amyiase of Aspergillus kawachii (EMBL#AB008370), i.e. a CBM having at least 50%, 60%, 70%, 80% or even at least 90% homology to the amino acid sequence of SEQ ID NO:6. Also preferred for the invention are the CBMs of Carbohydrate-Binding Module Family 20 ...
Virus infection of Aspergillus foetidus was documented over 40 years ago and was one of the first mycovirus infections described in a filamentous fungus. The virus, named Aspergillus foetidus virus (AfV), contains at least two types of icosahedral particles, called AfV-fast (-F) and AfV-slow (-S) virions, based on their relative electrophoretic mobilities. Here, we report the complete nucleotide sequence of the AfV-F genome isolated from virions purified from the prototype isolate of the fungus. The AfV-F double-stranded (ds) RNA genome is tetra-segmented, and the plus strands of each of the four segments, but not the minus strands, are polyadenylated. The organisation and sequences of the four AfV-F dsRNAs are similar to those described for Alternaria alternata virus 1, which we propose is a member of an emerging mycovirus genus ("Alternavirus") and family ("Alternaviridae"), which also includes AfV-F ...
Proteome IDi ,p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the ,a href="http://www.uniprot.org/manual/proteomes_manual">proteome,/a>. It consists of the characters UP followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.,p>,a href=/help/proteome_id target=_top>More...,/a>,/p> ...
A kinetic model to describe lovastatin biosynthesis by Aspergillus terreus ATCC 20542 in a batch culture with the simultaneous use of lactose and glycerol as carbon sources was developed. In order to do this the kinetics of the process was first studied. Then, the model consisting of five ordinary differential equations to balance lactose, glycerol, organic nitrogen, lovastatin and biomass was proposed. A set of batch experiments with a varying lactose to glycerol ratio was used to finally establish the form of this model and find its parameters. The parameters were either directly determined from the experimental data (maximum biomass specific growth rate, yield coefficients) or identified with the use of the optimisation software. In the next step the model was verified with the use of the independent sets of data obtained from the bioreactor cultivations. In the end the parameters of the model were thoroughly discussed with regard to their biological sense. The fit of the model to the ...
Aspergillus terreus ATCC ® 20542D-2™ Designation: Genomic DNA from Aspergillus terreus strain MF4845 (ATCC ® 20542™) Application:
Aspergillus terreus ATCC ® 20542D-2™ Designation: Genomic DNA from Aspergillus terreus strain MF4845 (ATCC ® 20542™) Application:
A detailed and comprehensive genome annotation can be considered a prerequisite for the analysis and interpretation of omics data. GO provides a framework for functional annotation and has been proven to be a valuable tool for omics data analysis, especially in combination with enrichment statistics. Currently, the GO reference genome project [23] provides the most comprehensive manually curated GO annotation for twelve model organisms and is intended to serve as a reference for automated mapping of GO annotation to organisms other than these major models. From the reference genome projects, Saccharomyces cerevisiae and Schizosaccharomyces pombe are most closely related to the genus Aspergillus.. A. nidulans has so far been the only Aspergillus species with comprehensive genome scale GO annotation based on both orthology mapping to S. cerevisiae and extensive manual curation [9] of gene-specific literature. We have thus mapped the A. nidulans GO annotation to all other Aspergillus species (see ...
Non-fumigatus Aspergillus species are the leading cause of Aspergillus infections in the tropical and subtropical regions of the world. In a prospective study between 2015 and 2016, a total of 150 bronchoalveolar (BAL) specimens was collected from patients suspected to pulmonary aspergillosis (PA) underlying immunodeficiencies in Mashhad, Northeastern Iran, located in the Middle East. All Aspergillus strains were phylogenetically identified at the species level by PCR-sequencing of partial β-tubulin gene. Overall, Aspergillus species were isolated from 20 specimens originating from 10 (50%) patients with cancer, 5 (25%) patients receiving corticosteroid therapy, 3 (15%) organ transplant recipients and 2 (10%) patients admitted to intensive care unit (ICU ...
List of fungus species in the genus Aspergillus. The Aspergillus genus includes several hundred fungus species, including: Contents A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Aspergillus acidusAspergillus aculeatinusAspergillus aculeatus Aspergillus aeneusAspergillus affinisAspergillus alabamensisAspergillus alliaceus Aspergillus amazonicusAspergillus ambiguusAspergillus amoenusAspergillus amstelodamiAspergillus amyloliquefaciensAspergillus amylovorusAspergillus anomalusAspergillus anthodesmisAspergillus apicalisAspergillus appendiculatusAspergillus arachidicolaAspergillus arenariusAspergillus arviiAspergillus asperescensAspergillus assulatusAspergillus astellatusAspergillus aurantiobrunneusAspergillus aureofulgensAspergillus aureolatusAspergillus aureoterreusAspergillus aureusAspergillus auricomusAspergillus australensisAspergillus austroafricanusAspergillus avenaceusAspergillus awamori Top A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Aspergillus baarnensisAspergillus ...
Aspergillus comprises a diverse group of species based on morphological, physiological and phylogenetic characters, which significantly impact biotechnology, food production, indoor environments and human health. Aspergillus was traditionally associated with nine teleomorph genera, but phylogenetic data suggest that together with genera such as Polypaecilum, Phialosimplex, Dichotomomyces and Cristaspora, Aspergillus forms a monophyletic clade closely related to Penicillium. Changes in the International Code of Nomenclature for algae, fungi and plants resulted in the move to one name per species, meaning that a decision had to be made whether to keep Aspergillus as one big genus or to split it into several smaller genera. The International Commission of Penicillium and Aspergillus decided to keep Aspergillus instead of using smaller genera. In this paper, we present the arguments for this decision. We introduce new combinations for accepted species presently lacking an Aspergillus name and ...
Orizin (EC 3.4.21.63, Aspergillus alkaline proteinaza, aspergilopeptidaza B, API 21, aspergilopepsin B, aspergilopepsin F, Aspergillus candidus alkalna proteinaza, Aspergillus flavus alkalna proteinaza, Aspergillus melleus semialkalna proteinaza, Aspergillus oryzae alkalna proteinaza, Aspergillus parasiticus alkalna proteinaza, Aspergillus serin proteinaza, Aspergillus sydowi alkalna proteinaza, Aspergillus soya alkalna proteinaza, Aspergillus melleus alkalna proteinaza, Aspergillus sulphureus alkalna proteinaza, prozim, P 5380, kiorinaza, seaproza S, semi-alkalna proteaza, sumizim MP, prozim 10, onoproza, onoproza SA, proteaza P, promelaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju. ...
Citation. Rokas, A., Payne, G., Fedorova, N. D., Baker, S. E., Machida, M., Yu, J., Georgianna, D. R., Dean, R. A., Bhatnagar, D., Cleveland, T. E., Wortman, J. R., Maiti, R., Joardar, V., Amedeo, P., Denning, D. W., Nierman, W. C.. What Can Comparative Genomics Tell Us About Species Concepts In the Genus Aspergillus?. Stud Mycol. 2007 Jan 01; 59: 11-7.. PubMed Citation. Abstract. Understanding the nature of species boundaries is a fundamental question in evolutionary biology. The availability of genomes from several species of the genus Aspergillus allows us for the first time to examine the demarcation of fungal species at the whole-genome level. Here, we examine four case studies, two of which involve intraspecific comparisons, whereas the other two deal with interspecific genomic comparisons between closely related species. These four comparisons reveal significant variation in the nature of species boundaries across Aspergillus. For example, comparisons between A. fumigatus and Neosartorya ...
The transfructosylating activity present in two commercial pectinase preparations (Pectinex Ultra SP-L, from Aspergillus aculeatus, and Rapidase TF, from Aspergillus niger) was studied. Pectinex Ultra SP-L, which has a high transferase/hydrolase ratio, was covalently immobilised on a polymethacrylate-based polymer (Sepabeads® EC) activated with epoxy groups. The influence of pore volume and average pore size on biocatalyst performance was studied for two of these carriers (Sepabeads EC-EP3 and EC-EP5). Several parameters that affect immobilisation such as buffer concentration, pH and amount (mg) of protein added per gram of support (varied over the range 30:1 to 200:1) were analysed. We found that Pectinex Ultra SP-L can be efficiently immobilised on these supports without adding any external salt or buffer. Using Sepabeads EC-EP5 -whose pore volume (1.67 cm3/g) and pore size (800 nm) are higher than those corresponding to Sepabeads EC-EP3- the activity towards sucrose reached 25.9 U/g ...
Neoxaline is a bio-active Aspergillus japonicus isolate. It is an antimitotic agent and shows weak inhibitory activity of blood platelet aggregation induced by simulation of the central nervous system. It has been synthesized through the "highly stereoselective introduction of a reverse prenyl group to create a quaternary carbon stereocenter using (−)-3a-hydroxyfuroindoline as a building block, construction of the indoline spiroaminal via cautious stepwise oxidations with cyclizations from the indoline, assembly of (Z)-dehydrohistidine, and photoisomerization of unnatural (Z)-neoxaline to the natural (E)-neoxaline." Satoshi Ōmura Neoxaline an antimiotic agent Hirano, A; Iwai, Y; Masuma, R; Tei, K; Omura, S (1979). "Neoxaline, a new alkaloid produced by Aspergillus japonicus. Production, isolation and properties". J Antibiot (Tokyo). 32 (8): 781-785. doi:10.7164/antibiotics.32.781. PMID 500498. Ideguchi, Tetsuya; Yamada, Takeshi (August 11, 2013). "Asymmetric Total Synthesis of Neoxaline". The ...
This paper reports the contamination of ready-to-use food thickeners, collected from the South-East geo-political zone in Nigeria, by aflatoxigenic form of Aspergillus species. A total of 150 samples from different open markets were observed for fungal contamination by using serial dilution-spread plate method. Although, Aspergillus, Fusarium and Penicillium were the most frequently isolated fungi, Aspergillus species were found to be the most prevalent in all the samples. Furthermore, Aspergillus flavus and Aspergillus parasiticus produced aflatoxin on yeast extract sucrose (YES) media incubated for 10 to 15 days at 27°C in a CO2 incubator. Aspergillus niger showed no sign of any secondary metabolite on the media, set at similar conditions. Although, light microscopy was used to identify these fungi, based on colony morphology, PCR method was used to confirm genetic variation among the Aspergillus group, using ITS set
This study reports differential expression of endoglucanase (EG) and beta-glucosidase (betaG) isoforms of Aspergillus terreus. Expression of multiple isoforms was observed, in presence of different carbon sources and culture conditions, by activity staining of poly acrylamide gel electrophoresis gels. Maximal expression of four EG isoforms was observed in presence of rice straw (28 U/g DW substrate) and corn cobs (1.147 U/ml) under solid substrate and shake flask culture, respectively. Furthermore, the sequential induction of EG isoforms was found to be associated with the presence of distinct metabolites (monosaccharides/oligosaccharides) i.e., xylose (X), G(1), G(3) and G(4) as well as putative positional isomers (G(1)/G(2), G(2)/G(3)) in the culture extracts sampled at different time intervals, indicating specific role of these metabolites in the sequential expression of multiple EGs. Addition of fructose and cellobiose to corn cobs containing medium during shake flask culture resulted in up
Gogoi, R.; Roy, A.K., 1993: Effect of foliar spraying of Aspergillus terreus Thom on sheath blight (ShB) and rice plant characteristics
The patient stayed 12 days at the hospital, and was submitted to several radiological and laboratory tests. Computerized axial tomography and resonance magnetic imaging were normal. The enzyme-linked immunosorbent assay (ELISA) for HIV 1 and 2 was repeatedly negative. Other two samples of CSF were collected and cultures to bacteria and fungi were negative, slide latex agglutination (SLA) tests to cryptococcal antigen, Haemophilus influenza, Neisseria meningitidis, Streptococcus pneumoniae were negative. The patient was followed on consultations and five CSF examinations were done during a follow up period of a month, when the diagnosis was finally established. In the first CSF sample, a polymerase chain reaction (PCR) to Mycobacterium tuberculosis was negative. In the next CSF sample, culture to fungi was positive to Aspergillus sp and the immunodiffusion test showed presence of antibodies against Aspergillus sp. Other immunological tests to Histoplasma, Cysticercus and Sporothrix were negative. ...
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003 ...
Metabolic products of Aspergillus terreus. VI. Metabolites of the strain IFO 8835. (3)​. The isolation and chemical structures of colorless metabolites. Arai, Kunizo; Shimizu, Sakae; Yamamoto, Yuzuru. Chemical & Pharmaceutical Bulletin (1981), 29(4), 1005-12 Metabolic products of Aspergillus terreus. X. Biosynthesis of asterriquinones. Arai, Kunizo; Yamamoto, Yuzuru. Chemical & Pharmaceutical Bulletin (1990), 38(11), 2929-32 ...
TY - JOUR. T1 - Hydrophobins from Aspergillus species cannot be clearly divided into two classes. AU - Jensen,Britt Guillaume. AU - Andersen,Mikael Rørdam. AU - Pedersen,Mona Højgaard. AU - Frisvad,Jens Christian. AU - Søndergaard,Ib. PY - 2010. Y1 - 2010. N2 - Background Hydrophobins are a family of small secreted proteins with a characteristic pattern of eight cysteine residues found exclusively in filamentous fungi. They have originally been divided into two classes based on their physical properties and hydropathy patterns, and are involved in the attachment of hyphae to hydrophobic structures, the formation of aerial structures and appear to be involved in pathogenicity. Findings Analysis of nine genome sequences from seven Aspergilli revealed fifty hydrophobins, where each species displayed between two to eight hydrophobins. Twenty of the identified hydrophobins have not previously been described from these species. Apart from the cysteines, very little amino acid sequence homology was ...
Esta tesis se compone de dos articulos: 1. Profilaxis con anfotericina B nebulizada contra la infección por Aspergillus en el trasplante de pulmón: Estudio de factores de riesgo. J Heart Lung Transplant 2001;20: 1274-1281. Introducción: La infección por Aspergillus spp. permanece como una causa importante de morbilidad y mortalidad en el trasplante de pulmón (TP). Algunas estrategias de profilaxis han sido ensayadas. Una de ellas es la anfotericina B nebulizada (nAB). Sin embargo, la eficacia de esta profilaxis no ha sido claramente demostradas. El objetivo de este estudio fue determinar si la profilaxis con nAB puede proteger contra la infección por Aspergillus spp. en los receptores de TP. Pacientes y métodos: Un estudio de factores de riesgo fue realizado en 55 pacientes con TP. 22 potenciales factores de riesgo fueron analizados. En 44 (80%) de los pacientes la nAB fue indicada como profilaxis. Se realizó un estudio multivariante utilizando regresión logística. Resultados: Dieciocho de 55
Despite the fact that PCR for the detection of Aspergillus in human specimens exists for almost two decades, the technique was not included in the European Organisation for Research and Treatment of Cancer and the Mycoses Study Group (EORTC/MSG) consensus definitions for diagnosing invasive fungal diseases (IFD) because of the lack of standardisation. In 2006, the UK Fungal PCR Consensus group published an agreed methodology for PCR aided diagnosis of IA within the UK and Ireland. Then, at the meeting of the International Society for Human and Animal Mycoses (ISHAM) in Paris in September 2006, a group of mainly European experts founded the European Aspergillus PCR Initiative (EAPCRI) involving more than 60 centres across Europe and centres in Australia and the Middle East.. The EAPCRI agreed to collaborate to develop a standard for Aspergillus PCR methodology and to validate this in clinical trials so that PCR could be incorporated into future consensus definitions for diagnosing IFD.. The ...
A panel of human serum samples spiked with various amounts of Aspergillus fumigatus genomic DNA was distributed to 23 centers within the European Aspergillus PCR Initiative to determine analytical performance of PCR. Information regarding specific methodological components and PCR performance was requested. The information provided was made anonymous, and meta-regression analysis was performed to determine any procedural factors that significantly altered PCR performance. Ninety-seven percent of protocols were able to detect a threshold of 10 genomes/ml on at least one occasion, with 83% of protocols reproducibly detecting this concentration. Sensitivity and specificity were 86.1% and 93.6%, respectively. Positive associations between sensitivity and the use of larger sample volumes, an internal control PCR, and PCR targeting the internal transcribed spacer (ITS) region were shown. Negative associations between sensitivity and the use of larger elution volumes (>/=100 mul) and PCR targeting ...
Background Microsatellites (or short tandem repeats, STRs) are the genetic markers of choice for studying Aspergillus fumigatus molecular epidemiology due to its reproducibility and high discrimination power. However, the specificity of these markers must ...
Misdiagnosis of Malt Workers disease - Aspergillus spp. including hidden diseases, diagnosis mistakes, alternative diagnoses, differential diagnoses, and misdiagnosis.
The University of Minnesota is one of the most comprehensive public universities in the United States and ranks among the most prestigious. It is both the state land-grant university, with a strong tradition of education and public service, and the states primary research university, with faculty of national and international reputation.
Finden Sie alle Bücher von Klich, Maren A. - Identification of Common Aspergillus Species. Bei der Büchersuchmaschine eurobuch.com können Sie antiquarische und Neubücher VERGLEICHEN UND SOFORT zum Bestpreis bestellen. 9789070351465
Also see the JGI Mycocosm for information on the Genomic Encyclopedia of Fungi: a range of interests into the fungal genomes that impact on mycorrhyzal symbiosis, plant pathogenicity, biocontrol as well as industrial applications such as lignocellulose degradation, sugar fermentation and other industrial applications. ...
The University of Minnesota is one of the most comprehensive public universities in the United States and ranks among the most prestigious. It is both the state land-grant university, with a strong tradition of education and public service, and the states primary research university, with faculty of national and international reputation.
SWISS-MODEL Repository entry for A1CE56 (BGALC_ASPCL), Probable beta-galactosidase C. Aspergillus clavatus (strain ATCC 1007 / CBS 51365 / DSM 816 / NCTC 3887 /NRRL 1)
SWISS-MODEL Repository entry for A1C4X8 (CFD1_ASPCL), Cytosolic Fe-S cluster assembly factor cfd1. Aspergillus clavatus (strain ATCC 1007 / CBS 51365 / DSM 816 / NCTC 3887 /NRRL 1)
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Another noteworthy publication in December is a major review of pathogenic fungal diseases entitled Hidden Killers, Human Fungal Infections. This review takes a worldwide perspective of most of the major fungal infections that occur globally, making the point that many of these diseases are not widely appreciated to be the major killers that they are. There is good awareness of the more superficial infections such as athletes foot, ringworm and nail infections but did you know that the former affects 20% of the world population while the latter affects up to 50% of the population of the world amongst those aged over 70!? This review contains many such surprising statistics for a range of fungal infections.. Most readers will be aware that Aspergillus infections are usually caused by inhaling spores and that we all generally inhale spores all of the time as spores of this genus (and a few others e.g. Penicillium) are present in our air all of the time. We also know that these spores can only ...
Riet-Correa F, Rivero R, Odriozola E, Adrien Mde L, Medeiros R M & Schild A L (2013) Mycotoxicoses of ruminants and horses. J Vet Diagn Invest 25 (6), 692-708 PubMed ...
Antibiotic activity of molds for Brucella. The isolation of two active substances from a strain of Aspergillus terreus Thom: one in crystalline form, the other as an amorphous concentrate ...
Tamara from masterly Los Angeles live to navigate sentences coming near Mount Whitney in Owens Valley. fact sur in Owens Valley. A download unique enzymes of aspergillus fungi of despairing at Solstice Canyon in Malibu.
Methyl (3-hydroxy-4-(2-hydroxy-6-methylheptan-2-yl)benzoyl)glycinate ( 1), a new sydonic acid derivative with glycinate, together with sydonic acid ( 2), sydowic acid ( 3), and...
A Phospholipase A1 which is capable of hydrolyzing a phospholipid to produce a 2-acyl lysophospholipid and is obtainable from species of the fungus Aspergillus.
Sol Niger testo canzone cantato da Babylon Whores: Under the sea Dead cities in the dark Dreaming themselves to be Alive once more ...
Looking for online definition of Aspergillus clavatus in the Medical Dictionary? Aspergillus clavatus explanation free. What is Aspergillus clavatus? Meaning of Aspergillus clavatus medical term. What does Aspergillus clavatus mean?
TY - JOUR. T1 - Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. AU - Szigeti, Gyöngyi. AU - Sedaghati, Ebrahim. AU - Mahmoudabadi, Ali Zarei. AU - Naseri, Ali. AU - Kocsubé, S.. AU - Vágvölgyi, C.. AU - Varga, J.. PY - 2012/7. Y1 - 2012/7. N2 - Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited ...
TY - JOUR. T1 - Fungal endophthalmitis caused by Aspergillus ustus in a patient following cataract surgery. AU - Taner Yildiran, Sinasi. AU - Mehmet Mutlu, Fatih. AU - Ali Saracli, Mehmet. AU - Uysal, Yusuf. AU - Gonlum, Ahmet. AU - Sobaci, Gungor. AU - Sutton, Deanna A.. PY - 2006/11. Y1 - 2006/11. N2 - The first case of postoperative endophthalmitis after cataract surgery caused by Aspergillus ustus, a species that has only rarely been implicated in human disease, is described. Six weeks after cataract surgery, a 67-year-old medically controlled diabetic patient presented with uveitis, mild ciliary injection and ocular discomfort. Anterior chamber paracentesis, vitreous tap and finally complete vitrectomy with removal of the capsular bag including the intraocular lens were performed and several sets of culture yielded A. ustus. Despite vigorous systemic (itraconazole and caspofungin) and intravitreal (amphotericin B and caspofungin) antifungal therapy, the endophthalmitis did not improve. The ...
LOINC Code 51529-6 Mold Allergen Mix 4 (Aspergillus fumigatus+Aspergillus niger+Aspergillus terreus+Aspergillus flavus) IgE Ab [Presence] in Serum by Multidisk
Declining oil reserves, political instability, climate change concerns and rising CO2 emissions have led to new interest in biofuels to supplement the growing demand for alternative and sustainable sources of transport fuels. Biofuels, which includes bio-ethanol, can be produced from renewable biomass resources that include dedicated crops (e.g. corn), by-products from agricultural processing activities (e.g. sugarcane bagasse) or even organic municipal waste. Although the positive environmental impact and sustainable nature of biofuels render it advantageous over fossil fuels [1], the cost-effective production of biofuels remains a challenge.. Starch, one of the most abundant polysaccharides in nature, has been used for commercial bio-ethanol production for a number of years, with a relatively mature technology developed for corn in the USA [2, 3]. The USA produced 52.6 billion litres of ethanol fuel in 2011, an increase from 49.2 billion litres in 2010 [4]. However, the limitations of current ...
Scanning electron micrograph (SEM) of Green mould (Aspergillus flavus) - conidiophore (fruiting structure) producing conidia (asexual conidia). Aspergillus flavus is a wide spread saprophyte found in soil, seeds, fruits and decaying vegetation. It is also found indoors on water damaged carpets and building materials. It is one of the Aspergillus species which causes aspergillosis, commonly in the tropics. Aspergillosis is a respiratory lung infection in people with weakened lungs or that are immune deficient (especially AIDS patients). This fungus produces aflatoxin, a group of virulent mycotoxins that are known animal carcinogens. These mycotoxins are can induce liver cancer in humans. The toxins may contaminate stored food (particularly carbohydrates). A. flavus has also been reported to be allergenic and its presence is associated with asthma. Magnification: x220 when shortest axis printed at 25 millimetres. - Stock Image C037/0238
ASPBA : The Platelia Aspergillus enzyme immunoassay (EIA) is a 1-stage immunoenzymatic sandwich microplate assay that detects galactomannan in bronchoalveolar lavage (BAL) specimens. The assay uses the rat monoclonal antibody EBA-2, which is directed against Aspergillus galactomannan. The monoclonal antibody is used 1) to coat the wells of the microplate and bind the antigen and 2) as the detector antibody in the conjugate reagent (peroxidase-linked monoclonal antibody).   Samples are heat-treated in the presence of EDTA in order to dissociate immune complexes and to precipitate proteins that could possibly interfere with the test. The treated samples and conjugate are added to the wells coated with the monoclonal antibody and incubated. A monoclonal antibody-galactomannan-monoclonal antibody/peroxidase complex is formed in the presence of Aspergillus antigen.   The strips are washed to remove any unbound material, and the substrate solution is added, which will react with the
Light-induced delayed luminescence (DL) of living organisms contains information on the quality of the living state of these organisms. Employing a LS-55 Luminescence Spectrometer, the changes of DL spectra of rice with Aspergillus flavus treating different time were observed. Rice with Aspergillus flavus treatment for a shorter time had a stronger intensity of DL. The polluted degree of Aspergillus showed a negative correlation with the intensity of DL. Comparing with the intensity of DL, we found that the concentration of aflatoxin in different polluted degree rice had negative correlation with the intensity of DL. We believe DL technique may be helpful in elaborating a fast, holistic, and non-invasive method for the rapid evaluation the polluted degree of rice by Aspergillus flavus.. © 2005 Chinese Optics Letters. PDF Article ...
A novel hemicellulase-producing fungal strain was isolated from a local soil sample. The organism is identified as Aspergillus fumigatus based on ribosomal RNA analyses. The Aspergillus strain, designated as 2NB, produces both enzymes acting on xylan backbone (xylanase and β-xylosidase), and those acting on side chains (or accessory enzymes) notably α-arabinofuranosidase and acetyl-xylan esterase. The Asperigillus hemicellulases are characterized as having relatively low xylanase and β-xylosidase activities but high side chain removal activities. The activity ratio of side-chain acting enzymes to xylanase is higher than that of the Multifect enzyme, a commercial hemicellulase product. The potential of the novel hemicellulases in lignocelluloses bioprocessing was demonstrated with alkaline-pretreated switchgrass as lignocellulose substrate with hemicellulase supplemented with a ratio of xylanase activity to filter paper unit of 2:1. Supplement of Aspergillus hemicellulases to commercial ...
1 Adams, T. H., Wieser, J. K., & Yu, J.-H. (1998). Asexual Sporulation in Aspergillus nidulans. Microbiology and Molecular Biology Reviews, 62(2), 545-545. doi: 10.1128/mmbr.62.2.545-545.1998 https://mmbr.asm.org/content/62/1/35.full 2 David, H., Özçelik, I. Ş., Hofmann, G., & Nielsen, J. (2008). Analysis of Aspergillus nidulans metabolism at the genome-scale. BMC Genomics, 9(1), 163. doi: 10.1186/1471-2164-9-163 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386489/ 3 Galagan JE; et al. (2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 (7071): 1105-15. doi:10.1038/nature04341. PMID 16372000. https://www.ncbi.nlm.nih.gov/pubmed/16372000 4 Gugnani, H. C. (2003). Ecology and taxonomy of pathogenic aspergilli. Frontiers in Bioscience, 8(6). doi: 10.2741/1002 ...
1 Adams, T. H., Wieser, J. K., & Yu, J.-H. (1998). Asexual Sporulation in Aspergillus nidulans. Microbiology and Molecular Biology Reviews, 62(2), 545-545. doi: 10.1128/mmbr.62.2.545-545.1998 https://mmbr.asm.org/content/62/1/35.full 2 David, H., Özçelik, I. Ş., Hofmann, G., & Nielsen, J. (2008). Analysis of Aspergillus nidulans metabolism at the genome-scale. BMC Genomics, 9(1), 163. doi: 10.1186/1471-2164-9-163 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386489/ 3 Galagan JE; et al. (2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature. 438 (7071): 1105-15. doi:10.1038/nature04341. PMID 16372000. https://www.ncbi.nlm.nih.gov/pubmed/16372000 4 Gugnani, H. C. (2003). Ecology and taxonomy of pathogenic aspergilli. Frontiers in Bioscience, 8(6). doi: 10.2741/1002 ...
ID G7XC55_ASPKW Unreviewed; 497 AA. AC G7XC55; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 22-NOV-2017, entry version 26. DE SubName: Full=Aspartyl aminopeptidase {ECO:0000313,EMBL:GAA84418.1}; GN ORFNames=AKAW_02533 {ECO:0000313,EMBL:GAA84418.1}; OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus OS awamori var. kawachi). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus. OX NCBI_TaxID=1033177 {ECO:0000313,EMBL:GAA84418.1, ECO:0000313,Proteomes:UP000006812}; RN [1] {ECO:0000313,EMBL:GAA84418.1, ECO:0000313,Proteomes:UP000006812} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NBRC 4308 {ECO:0000313,Proteomes:UP000006812}; RX PubMed=22045919; DOI=10.1128/EC.05224-11; RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., RA Takashita H., Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.; RT "Genome sequence of the white ...
Lung transplant recipients have the highest rate of Invasive Aspergillus (IA)infection among solid organ transplant recipients. The most important risk factor for the development of IA (which is associated with disease and death) is colonization of the organism in the respiratory tract.. Azoles are used to prevent the development of IA. Puffers containing antifungal medication can be used to treat the lungs without the need to worry about the medication interactions & side-effects in the blood. An example of this is the aerosolized amphotericin B. Its use is limited by the patients tolerating this medication that may cause cough, nausea & contraction of the air pathways.. The lipid preparation is better tolerated and has longer dosing interval than inhaled amphotericin B. The investigators propose a pilot study to determine the long-term safety of inhaled AmBisome administration of drug and generate the preliminary data on the effectiveness of this drug to prevent aspergillus colonization. ...
Aflatoxins are a potent carcinogenic mycotoxin and has become a research model of fungal secondary metabolism (SM). Via systematically investigating the APSES transcription factors (TFs), two APSES proteins were identified: AfRafA and AfStuA. These play central roles in the synthesis of mycotoxins including aflatoxin and cyclopiazonic acid, and fungal development and are consequently central to the pathogenicity of the aflatoxigenic A. flavus. Loss of AfRafA not only dramatically suppressed aflatoxin cluster expression, subsequently reducing toxin synthesis both in vitro and in vivo, but also impaired conidia and sclerotia development. More importantly, aflatoxin biosynthesis as well as conidia and sclerotia development were fully blocked in ΔAfStuA. In addition, our results supported that AfStuA regulated the aflatoxin synthesis in an AflR-dependent manner. Intriguingly, it was revealed that AfRafA and AfStuA exert an antagonistic role in the regulation of biosynthesis of cyclopiazonic acid. In
TWENTY FIVE Aspergillus isolates were screened from Giza Governorate and Saint Catherine Protectorate soils in Egypt. The antimicrobial activity of the crude extracts was tested against two Gram positive bacteria (Bacillus subtilis NRRL-B-4219, Staphylococcus aureus ATCC29213), four Gram negative bacteria (Alcaligenes faecalis B-170, Escherichia coli ATCC25922, Klebsiella pneumoniae ATCC10131, Pseudomonas aeruginosa ATCC27953), and one yeast (Candida albicans ATCC10231). The antioxidant activity using free radical scavenging model was assayed for the crude extracts. The antitumor activity for all of crude extracts was determined against HCT116 (Colon carcinoma cell line), HEPG2 (Liver carcinoma cell line), and MCF-7 (Breast carcinoma cell line). Aspergillus nomius was the most potent fungal species accordingly, it was chosen for bioactivity assay. Identification of this species was further confirmed at the molecular level based on nuclear ribosomal DNA 18s identities. An accession number, LC199488, was
The refined crystal structures of a proteolytic fragment of glucoamylase from Aspergillus awamori var. X100 have been determined at pH 6 and 4 to a resolution of 2.2 A and 2.4 A, respectively. The models include the equivalent of residues 1 to 471 of glucoamylase from Aspergillus niger and a complete interpretation of the solvent structure. The R-factors of the pH 6 and 4 structures are 0.14 and 0.12, respectively, with root-mean-square deviations of 0.014 A and 0.012 A from expected bondlengths. The enzyme has the general shape of a doughnut. The "hole" of the doughnut consists of a barrier of hydrophobic residues at the center, which separates two water-filled voids, one of which serves as the active site. Three clusters of water molecules extend laterally from the active site. One of the lateral clusters connects the deepest recess of the active site to the surface of the enzyme. The most significant difference in the pH 4 and 6 structures is the thermal parameter of water 500, the putative ...
TY - JOUR. T1 - Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. AU - Nuetzmann, Hans-Wilhelm. AU - Reyes-Dominguez, Yazmid. AU - Scherlach, Kirstin. AU - Schroeckh, Volker. AU - Horn, Fabian. AU - Gacek, Agnieszka. AU - Schümann, Julia. AU - Hertweck, Christian. AU - Strauss, Joseph. AU - Brakhage, Axel A. PY - 2011/8/23. Y1 - 2011/8/23. N2 - Sequence analyses of fungal genomes have revealed that the potential of fungi to produce secondary metabolites is greatly underestimated. In fact, most gene clusters coding for the biosynthesis of antibiotics, toxins, or pigments are silent under standard laboratory conditions. Hence, it is one of the major challenges in microbiology to uncover the mechanisms required for pathway activation. Recently, we discovered that intimate physical interaction of the important model fungus Aspergillus nidulans with the soil-dwelling bacterium Streptomyces rapamycinicus specifically ...
Moraes, A. M. L., M. Corrado, V. L. Holanda, G. L. Costa, M. Ziccardi, R. de Lourenço-de-Oliveira & P. C. Oliveira. Aspergillus from Brazilian mosquitoes - I. Genera Aedes and Culex from Rio de Janiero State, Mycotaxon 78: 413-422. 2001.. ABSTRACT: As part of an ongoing survey of potential biological control fungi from insects in Brazil. aspergilli were isolated from 625 mosquitoes belonging to 17 species in the genera Aedes and Culex. Two hundred and fifteen isolates belonging to 17 Aspergillus species were found. Aspergillus niger, Aspergillus flavus and Aspergillus nidulans were the most frequently isolated species. Two other species, Aspoergillus fischerianus and Aspergillus heteromorphus were new records for insects. The macro- and microcharacteristics of the Brazilian isolates are compared to those in previously published descriptions. The habitat and geographical distribution of these fungi in Brazil is reviewed.. KEYWORDS: biological control, taxonomy, entomogenous fungi. NOMENCLATURAL ...
Objective: To report the cases of 6 patients with fungus ball caused by Aspergillus fumigatus (aspergilloma) in the pleural cavity. Methods: Between 1980 and 2009, 391 patients were diagnosed with aspergilloma at the Santa Casa Hospital Complex in Porto Alegre, Brazil. The diagnosis of aspergilloma in the pleural cavity was made through imaging tests revealing effusion and pleural thickening with air-fluid level; direct mycological examination revealing septate hyphae, consistent with Aspergillus sp.; and positive culture for A. fumigatus in the surgical specimen from the pleural cavity. Results: Of the 391 patients studied, 6 (2%) met the established diagnostic criteria. The mean age of those 6 patients was 48 years (range, 29-66 years), and 5 (83%) were male. The most common complaints were cough, expectoration, and hemoptysis. Four patients (67%) had a history of tuberculosis that had been clinically cured. All of the patients were submitted to surgical removal of the aspergilloma, followed ...
In an application of the presented high-density microarray, we identify a carbon source-based response conserved in three aspergilli. The design of the study involving three different species, grown on three different defined minimal media, at three different values of pH, increases the likelihood of the found genes to be the true conserved "core" response to growth on xylose and not responses relying on an extra factor in addition to xylose (with the possible exception of abundant oxygen). We also believe this approach validates our argument that the xylanolytic transcriptional activator XlnR is a conserved system, even though it has not previously been studied in A. nidulans. Backed by the finding that the 5′-GGNTAAA-3′ motif is present and in some cases conserved as syntenic regions in all three species, we propose that the motif is indeed a XlnR motif and conserved in A. nidulans, A. niger, and A. oryzae. As a point of interest, a study of the homologous genes and their promoter regions ...
Further evidence on the interspecific protoplast fusion between Aspergillus oryzae and Aspergillus sojae and subsequent haploidization, with special Reference to their production of some hydrolyzing enzymes. (1990 ...
1IB4: The X-ray structure of Aspergillus aculeatus polygalacturonase and a modeled structure of the polygalacturonase-octagalacturonate complex.
According to the study of "Anti-inflammatory effects of glyceollins derived from soybean by elicitation with Aspergillus sojae" by Kim HJ, Sung MK, Kim JS., posted in US National Library of Medicine National Institutes of Health, researchers indicated that Glyceollins exert an anti-inflammatory effect, which is mediated through the inhibition of NF-κB activation in LPS-activated murine RAW264.7 cells. Glyceollins merit further study as potential therapeutic agents for inflammatory disorders ...
Fitted response profile (r² = 0.9290) for the lytic activity of Aspergillus tamarii as a function of temperature and reaction medium pH.
Culturing of tissue is currently the gold standard for the diagnosis of IA.11 This method not only yields Aspergillus spp, but further defines therapeutic options via susceptibility testing. However, the invasiveness of obtaining tissue makes culturing less desirable. In the absence of tissue specimens, bronchoalveolar lavage (BAL) fluid obtained from the upper and lower respiratory tracts can serve to establish the diagnosis of IA.12 Although BAL is a safe procedure, the overall sensitivity of culture using BAL specimens is relatively low (estimated at 50%).13 Blood sampling is the optimal noninvasive diagnostic approach for IA.12 Despite this noninvasiveness, however, Aspergillus spp are rarely isolated from blood through conventional culture techniques-hence the reliance on tissue specimens to secure a definitive diagnosis of IA.12 Since results from cultures are relatively slow to obtain overall, IA is well established by the time the culture is positive. These challenges have resulted in ...
The mortality of clinical Aspergillus infections necessitates consideration of the utility of a vaccine. We have found that Saccharomyces species can act as a protective vaccine against a lethal systemic Aspergillus infection, and describe experiments optimizing a subcutaneous regimen with killed yeast. Three injections of 2.5 mg given a week apart, 2 weeks prior to challenge, consistently, significantly, provided survival protection and reduction of infection in organs in survivors. The protection was independent of the strain of Saccharomyces, and possibly even the species, and could be demonstrated in several inbred (including C′-deficient) and outbred mouse strains. The protective moiety(ies) appeared to reside in the cell wall and was resistant to 100 °C, but not to protease or formalin. Alum potentiated the protection. The protection was comparable or superior to that of several Aspergillus-specific preparations described in the literature. Other studies have indicated that heat-killed
Aspergillus amyR protein: a transcriptional activator gene, involved in the amylolytic gene expression in Aspergillus oryzae; GenBank AB012945
Aspergillosis is caused by aspergillus species. Aspergillus can be detected via aspergillus antigen in the serum using the enzyme immunoassay. Other technique may include direct microscopic examination which may reveal the present of septate hyphae in spe
Agrococcus terreus sp. nov. and Micrococcus terreus sp. nov., isolated from forest soil.: Two bacterial strains, DNG5T and V3M1T, isolated from forest soil of t
BioAssay record AID 1085122 submitted by ChEMBL: Antifungal activity against Aspergillus niger at 100 ug/disk after 48 hr by disk diffusion test.
... is the dominant analogue of a family of polyphenyl fungal metabolites produced by Aspergillus candidus. The occurrence of this metabolite is a criterion in the polyphasic taxonomy of A. candidus. Terphenyllin has not been extensively studied but exhibits anti-oxidative activity, acts as a plant growth inhibitor, and shows weak activity against HIV integrase ...
Aspergillus fumigatus Basics Laboratory Metabolites Adverse health reactions Specific settings Diagnostic Bibliography Basics A. fumigatus has been associated with each and every type of health problems linked to environmental moulds: irritation and inflammation, allergy, asthma, pneumonitis, toxic effects as well as a wide range of infections. Infections have been reported
Purchase high purity enzyme endo-1-5-alpha-L-Arabinanase (Aspergillus niger) for use in research, biochemical enzyme assays and in vitro diagnostic analysis.
BioAssay record AID 114336 submitted by ChEMBL: Effective dose against Aspergillus fumigatus MTU6001 strain after iv administration in murine.
a haploid strain of the aspergillus nidulans carried the auxotrophic met-eight mutation conferring a requirement for, Hire Biology Expert, Ask Academics Expert, Assignment Help, Homework Help, Textbooks Solutions
Entry into mitosis in Aspergillus nidulans is regulated by the coordinate function of two serine/threonine protein kinases, NIMXCDC2 and NIMA. NIMXCDC2 is an essential histone H1 kinase that is structurally and functionally homologous to fission yeast p34cdc2 (Osmani et al., 1994). NIMA is a β-casein kinase and is structurally distinct from p34cdc2, containing an amino-terminal catalytic domain and a carboxyl-terminal regulatory domain (Osmani et al., 1988b; Lu et al., 1993; Pu and Osmani, 1995; Pu et al., 1995). Failure to properly activate either of these kinases in G2 prevents the initiation of mitosis, and the combined action of both kinases is critical for coordinating changes in chromosome, microtubule, and nuclear membrane structure during mitosis. For example, mutations preventing the activation of NIMXCDC2 in G2 normally arrests cells in late G2 (Osmani et al., 1991a; 1994). Although overexpression of NIMA can overcome this interphase arrest, the ensuing mitosis is disorganized such ...
Biological and chemical profiling of an Australian strain of the fungus Aspergillus unilateralis (MST-F8675), isolated from a soil sample collected near Mount Isa, Queensland, revealed a complex array of metabolites displaying broad chemotherapeutic properties. Noteworthy among these metabolites were a u
According to a Gente report (computer translated), two patients, ages 60 and 80, were in the ICU due to a general infection and another after an operation, have been transferred to another hospital and are in stable condition.. The hospital will carry out an "absolute cleaning", as well as a series of "exhaustive biological controls", explained the medical director, Antonio Zapatero. In addition, all the material in the unit will be dismantled and samples will be collected to determine the origin of the infection. This process includes the "cleaning of respirators" and all medical material and instruments.. The ICU is expected to reopen the middle of next week.. Spain is on Sale! Save up to 25% on select tours. Aspergillus is a filamentous fungus that can cause infections and is especially dangerous in people with compromised health. The detection of these two cases, along with two other suspects, motivated the decision to transfer to Reanimation four other patients who remained admitted to the ...
PECTINASE from Aspergillus/ACM903275 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
An acid protease from Aspergillus saitoi was immobilized on agarose beads of approximately 100 micrometers diameter. Solutions of gelatin were prepared in a saturated potassium bitartrate buffer and contacted with the immobilized enzyme. The Michaelis-Menten constant was determined to be 7.8 x 10-5 M at 25°C and pH of 3.5.. The maximum velocity of hydrolysis corrected for bed voidage was found to be 6.8 x 10-7 M per second under the same conditions.. ...
La aspergilosis es una enfermedad causada por el Aspergillus, un tipo de moho (hongo) común que vive en ambientes interiores y exteriores. La mayoría de las personas inhalan esporas de Aspergillus todos los días sin que lleguen a enfermarse. Sin embargo, las personas con el sistema inmunitario debilitado o con enfermedades pulmonares están en mayor riesgo de presentar problemas de salud por causa del Aspergillus. Existen diferentes tipos de aspergilosis. Algunos son leves, pero otros son muy graves.1. ...
PJM 54 (4) 263-269 [PDF]. Influence of N,N-bis(3-aminopropyl)dodecylamine on the mycelium growth and the cell wall composition of resistance and sensitive strains belonging to the genus Aspergillus ...
This page provides information on the status of the A. fumigatus Af293 genome. Data on this page are updated once a day. All the data displayed on this page are available in one or more files (Chromosomal Feature File; GO Annotations File) on the AspGD Download Data page. The Advanced Search tool can also be used to retrieve chromosomal features that match specific criteria. ...
Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan (By similarity).
Activity on β-1,3-glucan (curdlan) shown for the Aspergillus fumigatus Sun4 protein; activity on laminarioligosaccharides shown for Aspergillus fumigatus Sun4 protein and Candida albicans Sun41 protein; transglycosylation activity reported in PMID 23508952 ...
Serrazimes is a proteolytic blend composed of enzymes derived from the edible fungi, Aspergillus oryzae and Aspergillus melleus. Scientific studies indicate that Serrazimes may help maintain and support cardiovascular and lymphatic health through its ability to help break down excess fibrin. Serrazimes may also help support the immune system and promote a healthy response to external stresses. Serrazimes is safe and effective when used as directed, providing enzymatic activity equivalent to Serrapeptidate (aka, Serrapeptase ...
Rhozyme P-11™ is not an enzyme but a partially purified extract of Aspergillus oryzae comprising mostly glycosidases with some protease activity, originally produced by Rohm and Hass. There are actually several rhozymes from different species of Aspergillus, such as rhozyme HP150™, each trademarked. Rhozyme is used to break down plant cell walls, which are more polyglycan than protein.. ...
This conference has now clearly established itself as the premier forum for detailed and dedicated discussion of all aspects of Aspergillus infection and research, and previously published proceedings have been very well-received. Conference Goals
Draw blood in a plain red-top tube(s), serum gel tube is acceptable. Spin down and send 1 mL of serum refrigerated in a plastic vial.
There are over 180 species of Aspergillus fungi and they generally do not cause disease unless the host has a compromised immune system or gets a very big exposure to the fungus.
Zloženie:. Sójové boby (46,31%), voda, morská soľ (13,13%), alkohol, fermentačné činidlo: Aspergillus oryzae Tradičný japonský výrobok, ktorý sa podobne ako shoyu používa k dochucovaniu pokrmov.. Tamari na rozdiel od Shoyu má výraznejšiu chuť a hustejšiu konzistenciu tmavšiu farbu a neobsahuje lepok. ...
this is vandna thakur . i want to construct a growth curve for Aspergillus niger .Can u help me to give some information about this .and can u tell me that can i construct a growth curve of A.niger by taking optical density ,if yes then tell me at which wavelenth ? Actually i want to construct a standard curve for A.niger.Reply meas soon as , plz. -------------- next part -------------- An HTML attachment was scrubbed... URL: http://www.bio.net/bionet/mm/yeast/attachments/20110320/2c5d6ff4/attachment.html ...
Mutual Independence of Alkaline- and Calcium-mediated Signalling in Aspergillus fumigatus Refutes the Existence of a Conserved Druggable Signalling Nexus ...
Pontecorvo, G., Roper, J.A., Chemmons, L.M., Macdonald, K.D. and Bufton, A.W.J. (1953) The genetics of Aspergillus nidulans. Advances in Genetics, 5, pp. 141-238. (doi:10.1016/S0065-2660(08)60408-3) ...
Tomografia computadorizada da alta resolução Ambulatório para acompanhamento de pacientes portadores de bronquectasias História clínica Tomografia computadorizada da alta resolução Imunoglobulinas Cloro no suor Espermograma Triagem doença do colágeno Pesquisa e cultura de BAAR e fungos IgE, RAST para Aspergillus
The Kandadji dam project, one of the flagship programmes of Mahamadou Issoufous presidential campaign in 2011, is fraught with problems.
Aflatoxins are carcinogenic chemical metabolites produced by Aspergillus spp. of the section Flavi. In Kenya, Aspergillus flavus is the most prevalent and has been associated with several acute and chronic aflatoxin outbreaks in the past. In this study, we evaluated the occurrence of A. flavus in soils from two agro-ecological regions with contrasting climatic conditions, aflatoxin contamination histories and cropping systems. Aspergillus spp. were first isolated from soils before the identification and determination of their aflatoxigenicity. Further, we determined the occurrence of Pseudomonas and Bacillus spp. in soils from the two regions. These bacterial species have long been associated with biological control of several plant pathogens including Aspergillus spp. Our results show that A. flavus occurred widely and produced comparatively higher total aflatoxin levels in all (100%) study sites from the eastern to the western regions of Kenya. For the western region, A. flavus was detected in 4
The secretion of heterologous animal proteins in filamentous fungi is usually limited by bottlenecks in the vesicle-mediated secretory pathway. Using the secretion of bovine chymosin in Aspergillus awamori as a model, we found a drastic increase (40 to 80-fold) in cells grown with casein or casein phosphopeptides (CPPs). CPPs are rich in phosphoserine, but phosphoserine itself did not increase the secretion of chymosin. The stimulatory effect is reduced about 50% using partially dephosphorylated casein and is not exerted by casamino acids. The phosphopeptides effect was not exerted at transcriptional level, but instead, it was clearly observed on the secretion of chymosin by immunodetection analysis. Proteomics studies revealed very interesting metabolic changes in response to phosphopeptides supplementation. The oxidative metabolism was reduced, since enzymes involved in fermentative processes were overrepresented. An oxygen-binding hemoglobin-like protein was overrepresented in the proteome following
A previous study explored factors discriminating colonization and true infection among non-transplant, non-neutropenic patients with repeated Aspergillus spp. isolation from lower respiratory samples. The present study explored the evolution of patients with Aspergillus colonization in that study to determine the percentage of cases progressing to aspergillosis and time to development. Clinical records were retrospectively reviewed (for each patient from his end date in the past study) and data from all respiratory processes suffered by patients up to April 2015 were recorded. Comparisons of variables were performed between colonized patients that developed aspergillosis and those that did not. A Kaplan-Meier curve was used to describe time to development of aspergillosis in chronic obstructive pulmonary disease (COPD) patients for II-IV stages of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. Sixty seven colonized patients were followed, 12 of them (17.9%) developed
TY - JOUR. T1 - Spinal osteomyelitis due to Aspergillus flavus in a child. T2 - A rare complication after haematopoietic stem cell transplantation. AU - Beluffi, Giampiero. AU - Bernardo, Maria Ester. AU - Meloni, Giulia. AU - Spinazzola, Angelo. AU - Locatelli, Franco. PY - 2008/6. Y1 - 2008/6. N2 - We report the case of a child affected by acute myeloid leukaemia who was treated with allogeneic haematopoietic stem cell transplantation and developed cervicothoracic spinal osteomyelitis due to Aspergillus flavus. The diagnosis was difficult on a clinical basis, but made possible by conventional radiography and MRI.. AB - We report the case of a child affected by acute myeloid leukaemia who was treated with allogeneic haematopoietic stem cell transplantation and developed cervicothoracic spinal osteomyelitis due to Aspergillus flavus. The diagnosis was difficult on a clinical basis, but made possible by conventional radiography and MRI.. KW - Aspergillus. KW - Child. KW - Complication. KW - ...
1 sample to test for the following water damage indicator molds:. Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Aspergillus ochraceus, Aspergillus penicillioides, Aspergillus sclerotiorum, Aspergillus sydowii, Aspergillus unguis, Aspergillus versicolor, Aureobasidium pullulans, Chaetomium globosum, Cladosporium sphaerosperum, Eurotium (A) amstelodami, Paecilomyces variotii, Pencillium brevicompactum, Penicillium corylophilum, Penicillium crustosum, Penicillium spinulosum, Penicillium variabile, Stachybotrys chartarum.. ...
In most individuals, when benign antigens are inhaled, the lung responds with a tolerogenic immunological response [13-15]. However, in diseases such as ABPA, tolerance is lost or not established, and patients become sensitized to the inhaled fungal antigen Aspergillus fumigatus. We have previously shown that peripheral CD11c + DCs and TSLP-DCs from ABPA patients induce robust Th2 cytokine responses from autologous CD4+ T-cells in an OX40L-dependent manner [7]. In addition, in our CF cohort, vitamin D deficiency was associated with ABPA. In vitro treatment with 1,25-(OH)2 vitamin D3 reduced the robust Th2 response in patients with ABPA [7]. Based on data from our observational study, we initiated a clinical trial to assess the safety and the immunological effects of supplemental vitamin D3 (cholecalciferol) in patients with CF and ABPA.. This Phase I trial was implemented to test the safety and efficacy of vitamin D supplementation in CF patients with documented evidence of Af seinsitization. ...
Active Ingredients per 2 Soft Chews:. Yucca schidigera extract - 200 mg. Parsley leaf - 100 mg. Chamomile - 25 mg. Protease (Aspergillus oryzae) - 2044 HUT. Amylase (Aspergillus oryzae) - 546 DU. Cellulase (Aspergillus niger) - 13.6 CU. Maltase (Aspergillus niger) - 10.2 DP. Invertase (Aspergillus niger) - 0.6 INVU. Lipase (Aspergillus oryzae) - 6.8 LU. Probiotic Blend - 3.5 million CFU/serving. (Lactobacillus acidophilus, Bifidobacterium bifidum, Enterococcus thermophilus). Inactive Ingredients: Brewers Dried Yeast, Calcium Propionate, Canola Oil, Dried Cheese, Glycerin, Green Tea Extract, Liver Meal, Mixed Tocopherols, Natural Flavors, Rosemary Extract, Salmon Oil, Sorbic Acid, Soy Lecithin, Starch, Vegetable Oil, Water.. ...
Allergic Bronchopulmonary Aspergillosis (ABPA): Symptoms ❗ Workup ❗ Diagnosis ❗ Treatment ❗ Complications ❗ Causes ❗ Epidemiology ❗ Incidence ❗ Prognosis ❗ Check at SYMPTOMA.com Allergic bronchopulmonary aspergillosis is a disease characterized by a hypersensitivity reaction to aspergillus fumigatus after its repeated inhalation and is most…

Aspergillus flavus Link ATCC ® 204304™Aspergillus flavus Link ATCC ® 204304™

Aspergillus flavus ATCC ® 204304™ Designation: MCV-C#1 Application: Susceptibility testing Antifungal susceptibity testing Ref ... Aspergillus flavus Link (ATCC® 204304™) Strain Designations: MCV-C#1 / Product Format: frozen ...
more infohttps://www.atcc.org/Products/Quality_Control_Strains/By_Organization__Company/204304.aspx

Possible Mosquito Control by Silver Nanoparticles Synthesized by Soil Fungus (Aspergillus niger 2587)Possible Mosquito Control by Silver Nanoparticles Synthesized by Soil Fungus (Aspergillus niger 2587)

... by using the soil fungus Aspergillus niger 2587. The results recorded from UV-vis spectrophotometer and transmission electron ... Here, we have synthesized the silver nanoparticles (AgNPs) by using the soil fungus Aspergillus niger. 2587. The results ... Soni, N. and Prakash, S. (2013) Possible Mosquito Control by Silver Nanoparticles Synthesized by Soil Fungus (Aspergillus niger ... S. Namita and P. Soam, "Aspergillus niger Metabolites Efficacies against the Mosquito Larval (Culex quinquefasciatus, Anopheles ...
more infohttp://www.scirp.org/journal/PaperInformation.aspx?PaperID=31881

Aspergillus nodules; another presentation of Chronic Pulmonary Aspergillosis | BMC Pulmonary Medicine | Full TextAspergillus nodules; another presentation of Chronic Pulmonary Aspergillosis | BMC Pulmonary Medicine | Full Text

Ten patients (31 %) did not have an elevated Aspergillus IgG, and only 4 patients had elevated Aspergillus precipitins. Twelve ... This study aims to review the radiology, presentation, and histological features of lung nodules caused by Aspergillus spp. ... Aspergillus IgG antibody results were available for 32 patients. In ten patients (31 %) the Aspergillus IgG was within normal ... In four cases (4/14) Aspergillus DNA was detected by PCR but there was no growth of Aspergillus spp. by culture. ...
more infohttps://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-016-0276-3

MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus |...MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus |...

Aspergillus fumigatus, a ubiquitous human fungal pathogen, produces asexual spores (conidia), which are the main mode of ... MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus. ...
more infohttps://research.pasteur.fr/en/publication/myba-a-transcription-factor-involved-in-conidiation-and-conidial-viability-of-the-human-pathogen-aspergillus-fumigatus/

OSA | Changes of delayed luminescence spectra in rice of different polluted degree by Aspergillus flavusOSA | Changes of delayed luminescence spectra in rice of different polluted degree by Aspergillus flavus

Rice with Aspergillus flavus treatment for a shorter time had a stronger intensity of DL. The polluted degree of Aspergillus ... Changes of delayed luminescence spectra in rice of different polluted degree by Aspergillus flavus Wenli Chen, Da Xing, Weigui ... Employing a LS-55 Luminescence Spectrometer, the changes of DL spectra of rice with Aspergillus flavus treating different time ... "Changes of delayed luminescence spectra in rice of different polluted degree by Aspergillus flavus," Chin. Opt. Lett. 3, S188- ...
more infohttps://www.osapublishing.org/col/abstract.cfm?uri=col-3-S1-S188

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation<...Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation<...

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. ... Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. ... Recently, we discovered that intimate physical interaction of the important model fungus Aspergillus nidulans with the soil- ... Recently, we discovered that intimate physical interaction of the important model fungus Aspergillus nidulans with the soil- ...
more infohttps://researchportal.bath.ac.uk/en/publications/bacteria-induced-natural-product-formation-in-the-fungus-aspergil

Protein production and secretion in an Aspergillus nidulans mutant impaired in glycosylation. - Acta Biochimica Polonica -...Protein production and secretion in an Aspergillus nidulans mutant impaired in glycosylation. - Acta Biochimica Polonica -...

1953) The genetics of Aspergillus nidulans. Adv Genet.; 5: 141-238. * Sambrook J, Fritsch EF, Maniatis T. (1989) Molecular ... Vainstein LM, Peberdy J. (1991) Regulation of invertase in Aspergillus nidulans: the effect of different carbon sources. J Gen ... Overexpression of the yeast DPM1 gene encoding dolichylphosphate mannose synthase (DPMS) in an Aspergillus nidulans mutant ( ... 1993) Co-transformation with autonomously replicating helper plasmids facilitates gene cloning from an Aspergillus nidulans ...
more infohttp://psjd.icm.edu.pl/psjd/element/bwmeta1.element.bwnjournal-article-abpv52i1p195kz

Exposure of Aspergillus fumigatus to caspofungin results in the release, and de novo biosynthesis, of gliotoxin  - Maynooth...Exposure of Aspergillus fumigatus to caspofungin results in the release, and de novo biosynthesis, of gliotoxin - Maynooth...

Exposure of the Aspergillus fumigatus cultures to caspofungin (0.01, 0.1 or 1.0 μ g/ml) resulted in a reduction in cell growth ... Exposure of Aspergillus fumigatus to caspofungin results in the release, and de novo biosynthesis, of gliotoxin ... Eshwika, Ahmed and Kelly, Judy and Fallon, John P. and Kavanagh, Kevin (2013) Exposure of Aspergillus fumigatus to caspofungin ...
more infohttp://eprints.maynoothuniversity.ie/4192/

Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management | European Respiratory SocietyChronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management | European Respiratory Society

... direct evidence of Aspergillus infection (microscopy or culture from biopsy) or an immunological response to Aspergillus spp. ... Aspergillus antibody (precipitins) is elevated in over 90% of patients. Surgical excision of simple aspergilloma is recommended ... Patients with single Aspergillus nodules only need antifungal therapy if not fully resected, but if multiple they may benefit ... Less common manifestations include: Aspergillus nodule and single aspergilloma. All these entities are found in non- ...
more infohttps://erj.ersjournals.com/content/47/1/45.abstract

Toxins | Free Full-Text | Variation in Occurrence and Aflatoxigenicity of Aspergillus flavus from Two Climatically Varied...Toxins | Free Full-Text | Variation in Occurrence and Aflatoxigenicity of Aspergillus flavus from Two Climatically Varied...

In Kenya, Aspergillus flavus is the most prevalent and has been associated with several acute and chronic aflatoxin outbreaks ... Aspergillus spp. were first isolated from soils before the identification and determination of their aflatoxigenicity. Further ... These bacterial species have long been associated with biological control of several plant pathogens including Aspergillus spp ... Aflatoxins are carcinogenic chemical metabolites produced by Aspergillus spp. of the section Flavi. ...
more infohttps://www.mdpi.com/2072-6651/12/1/34

Aspergillus - WikipediaAspergillus - Wikipedia

Aspergillus consists of a few hundred species. Aspergillus is defined as a group of conidial fungi-that is, fungi in an asexual ... Aspergillus are found in millions in pillows. Species of Aspergillus are important medically and commercially. Some species can ... US 6069146 "GRAS Notification for Acid Lactase from Aspergillus oryzae Expressed in Aspergillus niger". Section 2. Wortman; ... doctors and scientists Aspergillus surveillance project at a large tertiary-care hospital. (PDF). The Aspergillus Genome ...
more infohttps://en.wikipedia.org/wiki/Aspergillus

Aspergillus oryzae - WikipediaAspergillus oryzae - Wikipedia

Aspergillus oryzae, known in English as koji (Japanese: 麹, Hepburn: kōji), is a filamentous fungus (a mold) used in Chinese and ... Fujita, Chieko, Tokyo Foundation Koji, an Aspergillus *^ Shurtleff, W.; Aoyagi, A. History of Koji - Grains and/or Soybeans ... Aspergillus oryzae genome from the Database of Genomes Analysed at NITE (DOGAN) ... The genome of A. oryzae is thus one-third larger than that of two related Aspergillus species, the genetics model organism A. ...
more infohttps://en.wikipedia.org/wiki/Aspergillus_oryzae

Aspergillus qinqixianii - WikipediaAspergillus qinqixianii - Wikipedia

Aspergillus qinqixianii is a species of the genus of Aspergillus which has been isolated from desert soil from the Taklimakan ... List of Aspergillus species "Aspergillus qinqixianii". www.mycobank.org. Chen, A.J.; Frisvad, J.C.; Sun, B.D.; Varga, J.; ... "Aspergillus qinqixianii". www.uniprot.org. Horie, Yoshikazu; Abliz, Paride; Hui, Yan; Fukiharu, Toshimitsu; Nishimura, Kazuko; ... Aspergillus qinqixianii produces asteltoxin, asperthecin, emericellin, 2-ω-hydroxyemodin, shamixanthones, terrein, curvularin ...
more infohttps://en.wikipedia.org/wiki/Aspergillus_qinqixianii

AspergillusAspergillus

See Klich and Pitts Aspergillus manual for more detailed workup. We use their methods for speciation of other Aspergillus sp. ... Aspergillus. p. kammeyer pkamm at THERAMP.NET Mon Nov 30 20:04:09 EST 1998 *Previous message: Examination ...
more infohttp://www.bio.net/bionet/mm/microbio/1998-November/014190.html

Category:Aspergillus - Wikimedia CommonsCategory:Aspergillus - Wikimedia Commons

Vernacular names [edit wikidata Category:Aspergillus linked to current category] [edit wikidata Aspergillus main topic of ... A. pseudoglaucus, A. monodii, A. Aspergillus, A. appendiculatus, A. intermedius, A. acidus, A. aculeatus, A. aeneus, A. affinis ... Media in category "Aspergillus". The following 200 files are in this category, out of 580 total. ... Retrieved from "https://commons.wikimedia.org/w/index.php?title=Category:Aspergillus&oldid=258638171" ...
more infohttps://commons.wikimedia.org/wiki/Category:Aspergillus

Aspergillus waksmaniiAspergillus waksmanii

Aspergillus sp. NRRL 179. ›Aspergillus waksmanii Hubka, S.W. Peterson, Frisvad & M. Kolarik 2013. ›NRRL 179. ›Neosartorya sp. ...
more infohttps://www.uniprot.org/taxonomy/454252

Aspergillus parasiticus | fungus | Britannica.comAspergillus parasiticus | fungus | Britannica.com

... the fungi Aspergillus flavus and A. parasiticus, which grow on improperly stored grains and peanuts. Aflatoxin B is one of the ... Other articles where Aspergillus parasiticus is discussed: cancer: Initiators: … ... the fungi Aspergillus flavus and A. parasiticus, which grow on improperly stored grains and peanuts. Aflatoxin B is one of the ...
more infohttps://www.britannica.com/science/Aspergillus-parasiticus

Aspergillus nidulans - Latest research and news | NatureAspergillus nidulans - Latest research and news | Nature

Aspergillus nidulans. Definition. Aspergillus nidulans is a filamentous soil fungus in the phylum Ascomcyetes. It is a fungal ... Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans *Kirstin Scherlach ...
more infohttp://www.nature.com/subjects/aspergillus-nidulans?error=cookies_not_supported&code=914a2919-33f9-4ff8-b134-b22277587ed3

Aspergillus fumigatus - Wellcome Sanger InstituteAspergillus fumigatus - Wellcome Sanger Institute

Aspergillus fumigatus. A. fumigatus causes more infections worldwide than any other mould. Four percent of all patients dying ... Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.. Nierman WC, Pain A, Anderson MJ, ... Andrew Brass at the University of Manchester, were initially funded to carry out a pilot genomic analysis of Aspergillus ...
more infohttps://www.sanger.ac.uk/resources/downloads/fungi/aspergillus-fumigatus.html

Antifungal Resistance in Aspergillus | Fungal Diseases | CDCAntifungal Resistance in Aspergillus | Fungal Diseases | CDC

The resistance can occur in the environment and in patients who are sick with an Aspergillus infection and have been taking ... Aspergillus can develop antifungal resistance and cause illness. ... Resistant Aspergillus infections are also found in people who ... Aspergillus fumigatus is the most common cause of human Aspergillus infections (both azole-resistant and nonresistant ... More research is needed about how Aspergillus becomes resistant and how to protect people from getting resistant Aspergillus ...
more infohttps://www.cdc.gov/fungal/diseases/aspergillosis/antifungal-resistant.html

Tracheobronchial Manifestations of Aspergillus InfectionsTracheobronchial Manifestations of Aspergillus Infections

In a small percentage of patients, the trachea and bronchi may be the main or even the sole site of Aspergillus infection. The ... Human lungs are constantly exposed to a large number of Aspergillus spores which are present in ambient air. These spores are ... Tracheobronchial Manifestations of Aspergillus Infections. Rafal Krenke and Elzbieta M. Grabczak Department of Internal ... Thus, invasive or potentially invasive Aspergillus airway diseases are discussed separately in three groups of patients: (1) ...
more infohttps://www.hindawi.com/journals/tswj/2011/865239/abs/

Aspergillus ochraceoroseus IBT 24754Aspergillus ochraceoroseus IBT 24754

Your basket is currently empty. i ,p>When browsing through different UniProt proteins, you can use the basket to save them, so that you can back to find or analyse them later.,p>,a href=/help/basket target=_top>More...,/a>,/p> ...
more infohttps://www.uniprot.org/taxonomy/1392256

Aspergillus - microbewikiAspergillus - microbewiki

Three Aspergillus genome manuscripts were published in Nature in December 2005 thus establishing Aspergillus as the leading ... Aspergillus carbonarius and Aspergillus ochraceus produce the toxin ochratoxin A (OTA), which contaminates grapes and coffee. ... As is the case with other members of Ascomycota, Aspergillus produces asci within ascocarps. Aspergillus gets its name from its ... "PCR detection assays for the ochratoxin-producing Aspergillus carbonarius and Aspergillus ochraceus species." International ...
more infohttps://microbewiki.kenyon.edu/index.php/Aspergillus
  • A microbial fungus - Aspergillus terreus was used to degrade phosphorus in Nigeria's Agbaja iron ore in the laboratory. (scirp.org)
  • C. Anyakwo and O. Obot, "Phosphorus Degradation Capability of Aspergillus terreus on Nigeria's Agbaja Iron Ore," Journal of Minerals and Materials Characterization and Engineering , Vol. 10 No. 12, 2011, pp. 1189-1196. (scirp.org)
  • Aspergillus oryzae (koji mold) was first used for the preparation of food stuffs in China almost 2,000 years ago and was used for one of the first commercial preparations of enzymes in the late 19th century ( 1 , 2 ). (pnas.org)
  • Since then, Aspergillus niger has also proven to be a high-yield producer of organic acids and enzymes, and today, both of these fungi are used as hosts for production of heterologous proteins ( 3 ). (pnas.org)