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Aspartic Acid ProteasesAspartic AcidPepstatinsAspartic Acid EndopeptidasesProtease InhibitorsEndopeptidasesNorleucinePeptide HydrolasesRhizopusMucorAmino Acid SequenceCathepsin DAspergillus oryzaeMolecular Sequence DataPepsin AHydrogen-Ion ConcentrationCathepsin EChymosinMitosporic FungiHIV ProteaseAmino AcidsCathepsinsAspergillus nigerSaccharomycopsisNitrophenolsPepsinogensSerine EndopeptidasesBinding SitesEpoxy CompoundsDiazonium CompoundsCladosporiumAspergillusAzo CompoundsXylarialesBase SequenceMutagenesis, Site-DirectedKineticsMolecular WeightPectobacterium carotovorumEncyclopedias as Topic2S Albumins, PlantCastor BeanFusariumTrichothecenesMycotoxinsTriticumZearalenonePlant DiseasesCerealsalpha-SynucleinParkinson DiseaseTremorSynucleinsSubstantia NigraNeurodegenerative Diseases
Aspartic Acid Proteases: A subclass of peptide hydrolases that depend on an ASPARTIC ACID residue for their activity.Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.Pepstatins: N-acylated oligopeptides isolated from culture filtrates of Actinomycetes, which act specifically to inhibit acid proteases such as pepsin and renin.Aspartic Acid Endopeptidases: A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.Protease Inhibitors: Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).Endopeptidases: A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.Norleucine: An unnatural amino acid that is used experimentally to study protein structure and function. It is structurally similar to METHIONINE, however it does not contain SULFUR.Peptide Hydrolases: Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.Rhizopus: A genus of zygomycetous fungi of the family Mucoraceae, order MUCORALES, a common saprophyte and facultative parasite of mature fruits and vegetables. It may cause cerebral mycoses in diabetes and cutaneous infection in severely burned patients.Mucor: A genus of zygomycetous fungi of the family Mucoraceae, order Mucorales. It is primarily saprophytic, but may cause MUCORMYCOSIS in man from spores germinating in the lungs.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cathepsin D: An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).Aspergillus oryzae: An imperfect fungus present on most agricultural seeds and often responsible for the spoilage of seeds in bulk storage. It is also used in the production of fermented food or drink, especially in Japan.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Pepsin A: Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Cathepsin E: An aspartic endopeptidase that is similar in structure to CATHEPSIN D. It is found primarily in the cells of the immune system where it may play a role in processing of CELL SURFACE ANTIGENS.Chymosin: The predominant milk-clotting enzyme from the true stomach or abomasum of the suckling calf. It is secreted as an inactive precursor called prorennin and converted in the acid environment of the stomach to the active enzyme. EC 3.4.23.4.Mitosporic Fungi: A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.HIV Protease: Enzyme of the human immunodeficiency virus that is required for post-translational cleavage of gag and gag-pol precursor polyproteins into functional products needed for viral assembly. HIV protease is an aspartic protease encoded by the amino terminus of the pol gene.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Cathepsins: A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.Aspergillus niger: An imperfect fungus causing smut or black mold of several fruits, vegetables, etc.Saccharomycopsis: Yeast-like ascomycetous fungi of the family Saccharomycopsidaceae, order SACCHAROMYCETALES, isolated from the stomach of rabbits and some other animals.NitrophenolsPepsinogens: Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.Serine Endopeptidases: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.Diazonium CompoundsCladosporium: A mitosporic Loculoascomycetes fungal genus including some economically important plant parasites. Teleomorphs include Mycosphaerella and Venturia.Aspergillus: A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.Azo CompoundsXylariales: An order of ascomycetous FUNGI which includes many economically important plant parasites as well as saprophytes.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Kinetics: The rate dynamics in chemical or physical systems.Molecular Weight: The sum of the weight of all the atoms in a molecule.Pectobacterium carotovorum: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that causes rotting, particularly of storage tissues, of a wide variety of plants and causes a vascular disease in CARROTS; and POTATO plants.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)2S Albumins, Plant: A major class of water-soluble seed storage proteins. Many proteins from this class are major PLANT ALLERGENS.Castor Bean: Common name for Ricinus communis, a species in the family EUPHORBIACEAE. It is the source of CASTOR OIL.Fusarium: A mitosporic Hypocreales fungal genus, various species of which are important parasitic pathogens of plants and a variety of vertebrates. Teleomorphs include GIBBERELLA.Trichothecenes: Usually 12,13-epoxytrichothecenes, produced by Fusaria, Stachybotrys, Trichoderma and other fungi, and some higher plants. They may contaminate food or feed grains, induce emesis and hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition.Mycotoxins: Toxic compounds produced by FUNGI.Triticum: A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.Zearalenone: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.Plant Diseases: Diseases of plants.Cereals: Seeds from grasses (POACEAE) which are important in the diet.alpha-Synuclein: A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.Synucleins: A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been implicated in a variety of human diseases. They were originally isolated from CHOLINERGIC FIBERS of TORPEDO.Substantia Nigra: The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis.Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.

Cloning of the SAP6 gene of Metschnikowia reukaufii and its heterologous expression and characterization in Escherichia coli. (1/51)

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Criteria for the differentiation between young and old Onchocerca volvulus filariae. (2/51)

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Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils. (3/51)

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Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure. (4/51)

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A novel bifunctional peptidic aspartic protease inhibitor inhibits chitinase A from Serratia marcescens: Kinetic analysis of inhibition and binding affinity. (5/51)

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Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV. (6/51)

FIV is a significant pathogen in the cat and is, in addition, the smallest available natural model for the study of lentivirus infections. Although divergent at the amino acid level, the cat lentivirus has an abundance of structural and pathophysiological commonalities with HIV and thus serves well as a model for development of intervention strategies relevant to infection in both cats and man. The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs.  (+info)

Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis. (7/51)

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Differences in exoenzyme production and adherence ability of Candida spp. isolates from catheter, blood and oral cavity. (8/51)

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Aspartic acid proteases in yeast - DTU Research DatabaseAspartic acid proteases in yeast - DTU Research Database
The production of the presumed GPI anchored, intracellular enzyme, Yapsin1, was investigated. The intra- and the extracellular protein production was followed as a function of growth in order to define the optimal conditions of the production of the enzyme, both in terms of secretion and in terms of amounts. The secreted protein was sequenced ...
OSAP 2018 Annual Conference Program - OSAPOSAP 2018 Annual Conference Program - OSAP
Substitutions within this program are gladly accepted. A substitution of your full registration is permitted prior to the conference by submitting a written request to [email protected] Please note there will be a $25 substitution fee for any change made to registrations. Onsite transfers are not permitted. Only one substitution is permitted per original registrant. The individual submitting the substitution request is responsible for all financial obligations (any balance due) associated with that substitution before the change can be made. Badge sharing, splitting, and reprints are strictly prohibited.. OSAP offers registrants contact information to facilitate networking after the course. By registering, you give OSAP permission to include your name and contact name in the list. If you do not wish to be included in the list, email your exclusion request to [email protected] by May 15, 2018.. OSAP takes photos during the course. By registering, you give OSAP permission to use any images taken at ...
Aspartic protease - WikipediaAspartic protease - Wikipedia
Aspartic proteases are a catalytic type of protease enzymes that use an activated water molecule bound to one or more aspartate residues for catalysis of their peptide substrates. In general, they have two highly conserved aspartates in the active site and are optimally active at acidic pH. Nearly all known aspartyl proteases are inhibited by pepstatin. Aspartic endopeptidases EC 3.4.23. of vertebrate, fungal and retroviral origin have been characterised.[1] More recently, aspartic endopeptidases associated with the processing of bacterial type 4 prepilin[2] and archaean preflagellin have been described.[3][4] Eukaryotic aspartic proteases include pepsins, cathepsins, and renins. They have a two-domain structure, arising from ancestral duplication. Retroviral and retrotransposon proteases (retroviral aspartyl proteases) are much smaller and appear to be homologous to a single domain of the eukaryotic aspartyl proteases. Each domain contributes a catalytic Asp residue, with an extended active ...
EP 1030911 A1 20000830 - HUMAN ASPARTIC PROTEASESEP 1030911 A1 20000830 - HUMAN ASPARTIC PROTEASES
293476355 - EP 1030911 A1 2000-08-30 - HUMAN ASPARTIC PROTEASES - [origin: WO0004137A1] The invention provides human aspartic proteases (NHAP) and polynucleotides which identify and encode NHAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of NHAP.[origin: WO0004137A1] The invention provides human aspartic proteases (NHAP) and polynucleotides which identify and encode NHAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of NHAP.
SMART: Pfam domain A1 PropeptideSMART: Pfam domain A1 Propeptide
This entry represents the N-terminal domain of the aspartic peptidases. Aspartic peptidase, also known as aspartyl proteases ([intenz:3.4.23.-]) are a widely distributed family of proteolytic enzymes [ (PUBMED:6795036) (PUBMED:2194475) (PUBMED:1851433) ] known to exist in vertebrates, fungi, plants, retroviruses and some plant viruses. Aspartate proteases of eukaryotes are monomeric enzymes which consist of two domains. Each domain contains an active site centred on a catalytic aspartyl residue. The two domains most probably evolved from the duplication of an ancestral gene encoding a primordial domain. Currently known eukaryotic aspartyl proteases are: ...
US 6613764 B1 - Aspartic Protease Inhibitors - The Lens - Free & Open Patent and Scholarly SearchUS 6613764 B1 - Aspartic Protease Inhibitors - The Lens - Free & Open Patent and Scholarly Search
The Lens serves almost all the patents and scholarly work in the world as a free, open and secure digital public good, with user privacy a paramount focus.
Aspartic peptidase, N-terminal (IPR012848) | InterPro | EMBL-EBIAspartic peptidase, N-terminal (IPR012848) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Napsin A Detection: ELISAs and AntibodiesNapsin A Detection: ELISAs and Antibodies
Novel Aspartic Proteinase of the PepSIN Family (Napsin A, or NAPSA) belongs to the peptidase A1 family and plays a role in pneumocyte surfactant processing. It is also known as aspartyl protease 4 (ASP4), KAP, Kdap, napsin-1, NAP1, NAPA, and SNAPA. Two closely related proteins are known, Napsin A and Napsin B. Napsin A is a single-chain, 38-kDa protein. It is expressed at high levels in human lung and kidney, and at lower levels in spleen. Napsin A expression has been detected in type II pneumocytes and in lung adenocarcinomas.. ...
Protease LASSO Screening Libraries / Protease Libraries / Targeted and Focused Screening Libraries | Life ChemicalsProtease LASSO Screening Libraries / Protease Libraries / Targeted and Focused Screening Libraries | Life Chemicals
Inhibition of HIV protease (HIVPR) or HIV reverse transcriptase (HIVRT) are two approaches to block viral replication. HIVPR is an aspartic acid protease that cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. Inhibition of its activity disrupts HIVs ability to replicate and infect additional cells. HIVRT is an RNA-dependent DNA polymerase that catalyzes the conversion/transcription of single-stranded RNA into DNA. Normal transcription involves the synthesis of RNA from DNA; hence, reverse transcription is the reverse of this. Discovery of small molecule inhibitors of these targets is facilitated by the use of ligand and receptor based screening using two different targeted libraries available from Life Chemicals available:. ...
Design and Synthesis of Inhibitors Targeting the Aspartic Proteases HIV-1 PR and BACE-1Design and Synthesis of Inhibitors Targeting the Aspartic Proteases HIV-1 PR and BACE-1
This thesis describes the synthesis of molecules designed for inhibition of two aspartic proteases, viral HIV-1 PR and human BACE-1. It also reports on the structure activity relationships of the targeted enzyme inhibitors.. It is estimated that currently 33 million people are infected with HIV, the causative agent of AIDS. The virus targets T-lymphocytes and macrophages of the human immune system. The HIV-1 PR plays an important role in the viral replication, and by inhibiting the enzyme the disease progression can be slowed down or even halted.. Herein is reported the design and synthesis of a series of HIV-1 PR inhibitors with novel P2 substituents of which several inhibit the enzyme in the nanomolar range. The aim of the second work was to further develop the inhibitors by the introduction of fluorine. Several attempts were performed to fluorinate different P2-substituents.. Alzheimers disease (AD) is neurodegenerative, progressive and fatal disorder of the brain. It is associated with ...
Pledge - OSAPPledge - OSAP
OSAP thanks its Super Sponsors for their support in 2017. Sponsorship does not imply endorsement by OSAP of a companys products or services. ...
The Toxoplasma Blog: Aspartic Proteases and a Novel, Dynamic and Cell-Cycle-Dependent Protease Localization in ToxoThe Toxoplasma Blog: Aspartic Proteases and a Novel, Dynamic and Cell-Cycle-Dependent Protease Localization in Toxo
Aspartic proteases are important virulence factors in pathogens like HIV, Candida albicans or Plasmodium falciparum. We report here the identification of seven putative aspartic proteases, TgASP1 to TgASP7, in the apicomplexan parasite Toxoplasma gondii. Bioinformatic and phylogenetic analysis of the TgASPs and other aspartic proteases from related Apicomplexa suggests the existence of five distinct groups of aspartic proteases with different evolutionary lineages. The members of each group share predicted biological features that validate the phylogeny. TgASP1 is expressed in tachyzoites, the rapidly dividing asexual stage of T.gondii. We present the proteolytic maturation and subcellular localization of this protease through the cell cycle. TgASP1 shows a novel punctate localization associated with the secretory system in non-dividing cells, and relocalizes dramatically and unambiguously to the nascent inner membrane complex of daughter cells at replication, before coalescing again at the end ...
SDV Dental Practices - OSAPSDV Dental Practices - OSAP
The information above is a resource prepared by the Organization for Safety, Asepsis and Prevention (OSAP) with the assistance and expertise of its members. OSAP is a nonprofit, independent organization providing information and education on infection control and prevention and patient and provider safety to dental care settings worldwide. This resource is an overview with links to more detailed information. Additional relevant information is available on CDC, OSHA, EPA, OSAP and other websites. Content provided is current at time of publication. OSAP assumes no liability for actions taken based on information herein.. ...
Protease Inhibitors | Thermo Fisher ScientificProtease Inhibitors | Thermo Fisher Scientific
Protease inhibitor cocktails and tablets target serine, cysteine, and aspartic acid proteases, and aminopeptidases. Metalloproteases are inhibited by the addition of EDTA, which is available in a separate vial in the liquid format, but included in the tablet format.. Thermo Scientific Halt liquid cocktails are available in 100 μL single-use format or 1, 5 and 10 mL pack sizes; the Thermo Scientific Pierce tablets come in two sizes for 10 or 50 mL volumes, to accommodate different volume and pricing needs. These tablets are formulated to dissolve quickly into a clear solution, and are fully compatible with all Pierce protein assays.. ...
eNews - November 2013 - The Australian Wine Research InstituteeNews - November 2013 - The Australian Wine Research Institute
Recent AWRI staff publications1559 Muhlack, R. Its time to power up. WBM (August): 39-41; 2013.1560 Dry, P. Ask the AWRI: Vines: Is an oldie necessarily a goodie? Aust. N.Z. Grapegrower Winemaker (596): p. 57; 2013.1561 Varela, C., Chambers, P., Johnson, D. Trials turn up new strategies for softening the kick in wine. Aust. N.Z. Grapegrower Winemaker (596): 70-73; 2013.1562 Carew, A.L., Smith, P., Close, D.C., Curtin, C., Dambergs, R.G. Yeast effects on Pinot noir wine phenolics, color, and tannin composition. J. Agric. Food Chem. 61 (41): 9892-9898; 2013.1563 van Sluyter, S.C., Warnock, N.I., Schmidt, S., Anderson, P., van Kan, J.A.L., Bacic, a., Waters, E.J. Aspartic acid protease from Botrytis cinerea removes haze-formation proteins during white winemaking. J. Agric. Food Chem. 61 (40): 9705-9711; 2013.1564 Pojer, E., Mattivi, F., Johnson, D., Stockley, C.S. The case for anthocyanin consumption to promote human health: A review. Comp. Rev. Food Sci. Food Safety 12 (5): 483-508; 2013.1565 ...
NewPage4 - OSAPNewPage4 - OSAP
Foundation General Fund » Donate Online. The OSAP Foundation is an educational foundation that supports education, research, service and policy development to promote safety and the control of infectious diseases in dental care settings worldwide. Contributions to the Foundation, a tax-exempt organization under Section 501(c)(3) of the Internal Revenue Code, are deductible for computing income and estate taxes. The tax identification number for the OSAP Foundation is 52-1963109. ...
Cascade synthesis with (triphenylphosphoranylidene)ethenone as a versatile reagent for fast synthesis of heterocycles and...Cascade synthesis with (triphenylphosphoranylidene)ethenone as a versatile reagent for fast synthesis of heterocycles and...
Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. In the work presented in this thesis, the use of MW-mediated heating has been expanded to address three fields of drug discovery, namely hit expansion, chemical library generation and genomics.. In the first project, potential inhibitors of malaria aspartic proteases were designed and synthesized, partly by MW-assisted organic chemistry, and evaluated with regard to their inhibitory efficacy on five malaria aspartic proteases and their selectivity over two human aspartic proteases. The synthetic work included the development of fast and convenient methods of MW-assisted formation of thiazolidines and epoxy esters. Some of the resulting structures ...
Patent US20110098321 - Salts of methyl 2-((r)-(3-chlorophenyl)((r)-1-((s)-2-(methylamino)-3-((r ... - Google PatentsPatent US20110098321 - Salts of methyl 2-((r)-(3-chlorophenyl)((r)-1-((s)-2-(methylamino)-3-((r ... - Google Patents
Mucic acid salts of a compound represented by the following structural formula: are disclosed. In particular, single crystalline mucic acid salts of the compound represented by structural formula (I) are characterized by a variety of properties and physical measurements. Methods of producing the mucic acid salts, using the salts to antagonize one or more aspartic proteases, and methods of treating a number of aspartic protease mediated disorders using the salts are described herein.
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Gentaur Molecular :Nacala \ D Aspartic Acid \ 03501-34Gentaur Molecular :Nacala \ D Aspartic Acid \ 03501-34
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SAP130抗体|Abcam中国|Anti-SAP130抗体(ab114978)SAP130抗体|Abcam中国|Anti-SAP130抗体(ab114978)
SAP130兔多克隆抗体(ab114978)可与人样本反应并经IP实验严格验证。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。
Plasmodium falciparum - encyclopedia article - CitizendiumPlasmodium falciparum - encyclopedia article - Citizendium
A lot of research is being done on Plasmodium falciparum in order to get rid of the disease. Researchers are hoping to discover new drugs and vaccines that could treat the disease or remove it entirely from the world. Researchers have been trying to find a new drug that would terminate the function of an important enzyme used by P. falciparum. They would like to discover a drug that can inhibit plasmepsins I and II, Plm I and Plm II. In P. falciparum, Plm I is the first to cleave the hemoglobin. Plm II also cleaves but it mainly takes action against denatured hemoglobin. Plm I and Plm II is said to be homologous to aspartic acid proteases, such as Cathepsin D (Cat D) in mammals. It would good if researchers can find an antimalarial drug that can stop Plm I from breaking down hemoglobin so that the P. falciparum parasite can die. Pepstatin A inhibits aspartic protease and prevents hemoglobin degradation. So this might be a successful drug. Researchers are also in the process of creating ...
An n →π* Interaction in the Bound Substrate of Aspartic Proteases Replicates the Oxyanion HoleAn n →π* Interaction in the Bound Substrate of Aspartic Proteases Replicates the Oxyanion Hole
Aspartic proteases regulate many biological processes and are prominent targets for therapeutic intervention. Structural studies have captured intermediates along the reaction pathway, including the Michaelis complex and tetrahedral intermediate. Using a Ramachandran analysis of these structures, we discovered that residues occupying the P1 and P1′ positions (which flank the scissile peptide bond) adopt the dihedral angle of an inverse γ-turn and polyproline type-II helix, respectively. Computational analyses reveal that the polyproline type-II helix engenders an n→π∗ interaction in which the oxygen of the scissile peptide bond is the donor. This interaction stabilizes the negative charge that develops in the tetrahedral intermediate, much like the oxyanion hole of serine proteases. The inverse γ-turn serves to twist the scissile peptide bond, vacating the carbonyl π∗ orbital and facilitating its hydration. These previously unappreciated interactions entail a form of ...
Microbiology Society Journals | Spirochaeta americana sp. nov., a new haloalkaliphilic, obligately anaerobic spirochaete...Microbiology Society Journals | Spirochaeta americana sp. nov., a new haloalkaliphilic, obligately anaerobic spirochaete...
A novel, obligately anaerobic, mesophilic, haloalkaliphilic spirochaete, strain ASpG1T, was isolated from sediments of the alkaline, hypersaline Mono Lake in California, USA. Cells of the Gram-negative strain were motile and spirochaete-shaped with sizes of 0·2-0·22×8-18 μm. Growth of the strain was observed between 10 and 44 °C (optimum 37 °C), in 2-12 % (w/v) NaCl (optimum 3 % NaCl) and between pH 8 and 10·5 (optimum pH 9·5). The novel strain was strictly alkaliphilic, required high concentrations of carbonates in the medium and was capable of utilizing d-glucose, fructose, maltose, sucrose, starch and d-mannitol. End products of glucose fermentation were H2, acetate, ethanol and formate. Strain ASpG1T was resistant to kanamycin and rifampicin, but sensitive to gentamicin, tetracycline and chloramphenicol. The G+C content of its DNA was 58·5 mol%. DNA-DNA hybridization analysis of strain ASpG1T with its most closely related species, Spirochaeta alkalica Z-7491T, revealed a hybridization value
RCSB PDB - 1APT: CRYSTALLOGRAPHIC ANALYSIS OF A PEPSTATIN ANALOGUE BINDING TO THE ASPARTYL PROTEINASE PENICILLOPEPSIN...RCSB PDB - 1APT: CRYSTALLOGRAPHIC ANALYSIS OF A PEPSTATIN ANALOGUE BINDING TO THE ASPARTYL PROTEINASE PENICILLOPEPSIN...
1APT: Crystallographic Analysis of a Pepstatin Analogue Binding to the Aspartyl Proteinase Penicillopepsin at 1.8 Angstroms Resolution
Structure Cluster - 1APT: CRYSTALLOGRAPHIC ANALYSIS OF A PEPSTATIN ANALOGUE BINDING TO THE ASPARTYL PROTEINASE...Structure Cluster - 1APT: CRYSTALLOGRAPHIC ANALYSIS OF A PEPSTATIN ANALOGUE BINDING TO THE ASPARTYL PROTEINASE...
1APT: Crystallographic Analysis of a Pepstatin Analogue Binding to the Aspartyl Proteinase Penicillopepsin at 1.8 Angstroms Resolution
Penis Enlargement Products: (GNC) What Is D Aspartic Acid Used For GolanWinesPenis Enlargement Products: (GNC) What Is D Aspartic Acid Used For GolanWines
What Is D Aspartic Acid Used For how to take sizegenix, What Is D Aspartic Acid Used For adderall xr 20 mg cost => GolanWines 22 06 2019
Application and appreciation of chemical sand fixing agent-poly (aspartic acid) and its composites - GeoScience.netApplication and appreciation of chemical sand fixing agent-poly (aspartic acid) and its composites - GeoScience.net
Yang, J.; Cao, H.; Wang, F.; Tan, T., 2007: Application and appreciation of chemical sand fixing agent-poly (aspartic acid) and its composites
Plasmepsin - WikipediaPlasmepsin - Wikipedia
Plasmepsins are a class of at least 10 enzymes (EC 3.4.23.38 and EC 3.4.23.39) produced by the Plasmodium falciparum parasite. There are ten different isoforms of these proteins and ten genes coding them respectively in Plasmodium (Plm I, II, III, IV, V, VI, VII, IX, X and HAP). It has been suggested that the plasmpesin family is smaller in other human Plasmodium species. Expression of Plm I, II, IV, V, IX, X and HAP occurs in the erythrocytic cycle, and expression of Plm VI, VII, VIII, occurs in the exoerythrocytic cycle. Through their haemoglobin-degrading activity, they are an important cause of symptoms in malaria sufferers. Consequently, this family of enzymes is a potential target for antimalarial drugs. Plasmepsins are aspartic acid proteases, meaning their active site contains two aspartic acid residues. These two aspartic acid residue act respectively as proton donor and proton acceptor, catalysing the hydrolysis of peptide bond in proteins. There are four types of plasmepsins, closely ...
A fourth secreted aspartyl proteinase gene (SAP4) and a CARE2 repetitive element are located upstream of the SAP1 gene in...A fourth secreted aspartyl proteinase gene (SAP4) and a CARE2 repetitive element are located upstream of the SAP1 gene in...
Candida albicans secreted aspartyl proteinases (Sap), products of the SAP genes, which are presumed to act as virulence factors. In the C. albicans strain WO-1, the ability to secrete Sap1 is regulated with switch phenotype, another putative virulence factor. KpnI restriction fragment length polymorphisms differentiate between several distinct SAP1 alleles in laboratory and clinical strains. Both SAP1 alleles from strain WO-1 along with their 5- and 3-flanking regions were cloned and sequenced, as were both alleles from another strain, SS. The 5-flanking regions were remarkably similar in all four of the sequenced alleles over approximately 1,500 nucleotides. S1 analysis revealed that both alleles of WO-1 are transcribed. Characterization of the one allele from strain WO-1 identified a 284-nucleotide insertion flanked by 8-bp direct repeats that shows homology to the CARE2 repetitive element and that is not present in the other alleles. Characterization of the SAP1 alleles also identified a ...
Bioline International Official Site (site up-dated regularly)Bioline International Official Site (site up-dated regularly)
is one of the three main causative agents of human schistosomiasis, a major health problem with a vast socio-economic impact. Recent advances in the proteomic analysis of schistosomes have revealed that peptidases are the main virulence factors involved in the pathogenesis of this disease. In this context, evolutionary studies can be applied to identify peptidase families that have been expanded in genomes over time in response to different selection pressures. Using a phylogenomic approach, we searched for expanded endopeptidase families in the S. mansoni predicted proteome with the aim of contributing to the knowledge of such enzymes as potential therapeutic targets. We found three endopeptidase families that comprise leishmanolysins (metallopeptidase M8 family), cercarial elastases (serine peptidase S1 family) and cathepsin D proteins (aspartic peptidase A1 family). Our results suggest that the Schistosoma members of these families originated from successive gene duplication events in the ...
1-Aspartic Acid | definition of 1-Aspartic Acid by Medical dictionary1-Aspartic Acid | definition of 1-Aspartic Acid by Medical dictionary
Looking for online definition of 1-Aspartic Acid in the Medical Dictionary? 1-Aspartic Acid explanation free. What is 1-Aspartic Acid? Meaning of 1-Aspartic Acid medical term. What does 1-Aspartic Acid mean?
Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.
Assay-guided fractionation of the ethanol extract of Tovomita krukovii resulted in the identification of four new xanthones (1 - 4) and ten known compounds (5 - 14). The structures of compounds 1 - 14 were determined by spectral data to be 3,5-dihydr
News DetailsNews Details
In conjunction with this month-long emphasis on the critical role of infection control in dentistry, OSAP is launching a major collaborative program called Safest Dental Visit™. This new educational program encourages a greater commitment to infection control and safety and helps dental teams educate and train staff, promote a safe and professional environment, increase patient confidence and loyalty, attract new patients and enhance the image of the practice.. As an OSAP Super Sponsor, Patterson Dental serves as a strategic partner for messaging in OSAPs infection control initiatives. Recently Patterson Dental was named a co-recipient of the 2015 Dr. Milton Schaefer Award for leadership and support in advancing OSAPs mission to be the leading advocate for the safe and infection-free delivery of oral healthcare.. ...
REN Protein, renin - Creative BioMartREN Protein, renin - Creative BioMart
Prorenin is a glycosylated aspartic protease that consists of 2?homologouslobes and is the precursor of renin. Renin activates the renin-angiotensinsystem by cleaving angiotensinogen, produced by the liver, to yield angiotensinI, which is further converted into angiotensin II by ACE, theangiotensin-converting enzyme primarily within the capillaries of the lungs. Ithas been reported that the levels of circulating prorenin (but not renin) areincreased in diabetic subjects.
2:19 pm2:19 pm
Related Articles. Structure-Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry.. Angew Chem Int Ed Engl. 2014 Feb 14 ...
D Aspartic Acid Testosterone EnhancementD Aspartic Acid Testosterone Enhancement
... is the best way to use an over the counter non steroidal product to increase your testosterone naturally!
July 2009 | The Homestead HobbyistJuly 2009 | The Homestead Hobbyist
No, I am not one. But I did apply today for the course here in DC. Interviews are in December, and the course is in February and March. 2.5 hours every Tuesday and Thursday night. Geez! The 50 hours of volunteering afterward is much easier to swallow--I volunteer anywhere from five to 15 hours in any given week anyway (an average of about six or seven, however--15 is peak time, which has been in June and December for me here), three or four of which is at a Master Gardener-approved volunteering place already (the Youth Garden). For a lot of people, I think, the 50 hours of volunteering is more difficult than the book learning and the test, but for me? Thatll be a snap ...
Financial Aid | Nipissing UniversityFinancial Aid | Nipissing University
OSAP provides funding for postsecondary students with financial need to help support their educational costs. OSAP also provides supplementary funding for students with disabilities to help cover additional disability-related educational expenses (see below).. We, Student Accessibility Services (SAS) at Nipissing University, recommend that you complete the OSAP application process to see if you may be eligible for disability-related funding to help cover additional disability-related educational costs that you may have such as tutoring, or note taking support, or assistive technology. To qualify, you must demonstrate at least $1 of financial need.. When you apply for OSAP online, you can self-identify as a student with a permanent disability by checking off a box on the form. You will need to provide documentation of your disability to Student Accessibility Services, and we will verify your status as a student with a permanent disability to the Financial Aid Office and to OSAP.. Some of the ...
Patent US7115652 - Aspartyl protease inhibitors - Google PatentenPatent US7115652 - Aspartyl protease inhibitors - Google Patenten
The present invention provides compounds having the formula: wherein R1, R′, R2, R3, R3′, R4, X1, X2 and X3 are as defined herein, and pharmaceutical compositions thereof. The present invention also provides methods of inhibiting proteases, more specifically aspartyl proteases. In certain embodiments, compounds inhibit BACE (β-site APP-cleaving enzyme), and thus are useful in the treatment or prevention of a disease characterized by β-amyloid deposits in the brain (including, but not limited to, Alzheimers Disease). The present invention also provides methods for preparing compounds of the invention.
Alexander Wlodawer, Ph.D. | Center for Cancer Research - National Cancer InstituteAlexander Wlodawer, Ph.D. | Center for Cancer Research - National Cancer Institute
Dr. Wlodawer is a structural biologist investigating the relationship between protein structure and function, mainly by high-resolution X-ray diffraction. Some of his areas of interest include elucidating structural features of macromolecules that could explain their importance to understanding cancer and AIDS. Examples include proteases, viral glycoproteins and enzymes, and
RNAseq revealed the important gene pathways controlling adaptive mechanisms under waterlogged stress in maize | Scientific...RNAseq revealed the important gene pathways controlling adaptive mechanisms under waterlogged stress in maize | Scientific...
Waterlogging causes yield penalty in maize-growing countries of subtropical regions. Transcriptome analysis of the roots of a tolerant inbred HKI1105 using RNA sequencing revealed 21,364 differentially expressed genes (DEGs) under waterlogged stress condition. These 21,364 DEGs are known to regulate important pathways including energy-production, programmed cell death (PCD), aerenchyma formation, and ethylene responsiveness. High up-regulation of invertase (49-fold) and hexokinase (36-fold) in roots explained the ATP requirement in waterlogging condition. Also, high up-regulation of expansins (42-fold), plant aspartic protease A3 (19-fold), polygalacturonases (16-fold), respiratory burst oxidase homolog (12-fold), and hydrolases (11-fold) explained the PCD of root cortical cells followed by the formation of aerenchyma tissue during waterlogging stress. We hypothesized that the oxygen transfer in waterlogged roots is promoted by a cross-talk of fermentative, metabolic, and glycolytic pathways that
10. Gastrointestinal Nematode Vaccines10. Gastrointestinal Nematode Vaccines
Hookworm filariform Ac-APR -1 is a cathepsin D aspartic protease from A. caninum which initiates digestive cascade ⇒ If you can block this activity it should
Amount of Aspartic acid, D-AA, Asp, or D, α-amino acid in Burdock root, raw naturalAmount of Aspartic acid, D-AA, Asp, or D, α-amino acid in Burdock root, raw natural
How much of Aspartic acid, D-AA, Asp, or D, α-amino acid is present in Burdock root, raw natural in details, quantity how high or low Aspartic acid, D-AA, Asp, or D, α-amino acid nutrient content it has.
ChemIDplus - 190195-65-4 - Aspartic acid, N-((1S)-1,2-dicarboxyethyl)-3-hydroxy-, sodium salt (1:4) - Searchable synonyms,...ChemIDplus - 190195-65-4 - Aspartic acid, N-((1S)-1,2-dicarboxyethyl)-3-hydroxy-, sodium salt (1:4) - Searchable synonyms,...
190195-65-4 - Aspartic acid, N-((1S)-1,2-dicarboxyethyl)-3-hydroxy-, sodium salt (1:4) - Searchable synonyms, formulas, resource links, and other chemical information.
education Archives - Off the Cuspeducation Archives - Off the Cusp
Are you up-to-date on the latest guidelines and standards from CDC, OSAP, OSHA and your state government? Do you stay current with industry news and continuing education? Develop more confidence in your infection control management by increasing focus on training, documentation and ongoing education. Follow […]. ...
Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice | mBioSecretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice | mBio
Secretory aspartyl proteinases (Sap) have long been considered key virulence traits of C. albicans, with rather strong experimental and clinical evidence for a major role in vaginal candidiasis (1, 3). However, the mechanisms by which this family of enzymes is involved in vaginal disease have remained unclear. Sap are active enzymes with a wide range of substrate specificities (26). Since some of these substrates (e.g., complement, histatins, and E-cadherin, and also Abs) play critical roles in both innate and adaptive immune responses, Sap expression is thought to enable the fungus to evade host immunity by enzymatic proteolysis of one or more of the above factors (1, 3). Concurrently, studies in well-established animal models and reconstituted human vaginal epithelia have provided indirect clues for a role of some members of the Sap family in facilitating fungus adherence and penetration into epithelial tissues (27-30). Evidence gathered with the use of anti-Sap Abs supports this proadherence ...
Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides,...Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides,...
Bradykinin-related peptides, universal mediators of inflammation collectively referred to as the kinins, are often produced in excessive amounts during microbial infections. We have recently shown that the yeast Candida albicans, the major fungal pathogen to humans, can exploit two mechanisms to enhance kinin levels at the sites of candidial infection, one depending on adsorption and activation of the endogenous kinin-generating system of the host on the fungal cell wall and the other relying on cleavage of kinin precursors, the kininogens, by pathogen-secreted proteases. This work aimed at assigning this kininogenase activity to the major secreted aspartic protease of C. albicans (SAP2). The purified SAP2 was shown to cleave human kininogens, preferably the low molecular mass form (LK) and optimally in an acidic environment (pH 3.5-4.0), and to produce two kinins, Met-Lys-bradykinin and its derivative, {[}Hydroxyproline(3)]-Met-Lys-bradykinin, both of which are capable of interacting with ...
Quantum-Chemical Study of the Catalytic Mechanism of Aspartic Proteinases | SpringerLinkQuantum-Chemical Study of the Catalytic Mechanism of Aspartic Proteinases | SpringerLink
Aspartic proteinases are a group of enzymes functioning by a general base mechanism, the water molecule serving as nucleophile.1The X-ray data (for example references 2-4) clearly show that two...
Updates | SabinUpdates | Sabin
In partnership with the Fraunhofer Center for Molecular Biotechnology and the Walter Reid Army Institute for Research, the Sabin Vaccine Institute has successfully expressed the hookworm-derived antigen Na-APR-1. ...
Research Brief: New BACE Inhibitor Joins the Fold | ALZFORUMResearch Brief: New BACE Inhibitor Joins the Fold | ALZFORUM
Vitae Pharmaceuticals BACE inhibitor, VTP-37948, lowered cerebrospinal fluid Aβ by up to 80 percent in healthy volunteers, according to topline data from a Phase 1 clinical trial. A second Phase 1 trial that used a single-ascending-dose strategy suggested that volunteers tolerated the drug well. Vitae chief scientific officer Richard Gregg told Alzforum that the companies will soon test the inhibitor in multiple rising dose trials. Results should be available early next year, said Vitae CEO Jeffrey Hatfield. The company will develop the inhibitor, also known as BI 1181181, in partnership with Boehringer Ingelheim.. Vitae used a structure-based approach to develop the drug, which fits the catalytic pocket of the aspartyl protease. VTP-37948 joins BACE inhibitors being developed by other pharmaceutical companies including Merck, AstraZeneca/Lilly, and Novartis. The Vitae inhibitor, like the other compounds under development, does not discriminate between β-secretase isoforms, blocking both ...
Pepstatin Inhibition Mechanism | SpringerLinkPepstatin Inhibition Mechanism | SpringerLink
Pepstatin is a strong inhibitor for all acid proteases. It does not inhibit other groups of proteases, such as the neutral and alkaline proteases (1). The unusual potency of pepstatin toward acid prot
Pediaven AP-HP Nouveau-NE 1 (Alanine; Arginine; Aspartic Acid...) AGEPS LaboratoirePediaven AP-HP Nouveau-NE 1 (Alanine; Arginine; Aspartic Acid...) AGEPS Laboratoire
Pediaven AP-HP Nouveau-NE 1 information about active ingredients, pharmaceutical forms and doses by AGEPS Laboratoire, Pediaven AP-HP Nouveau-NE 1 indications, usages and related health products lists
Amyloid precursor protein secretaseAmyloid precursor protein secretase
NeurodegenerationNeurodegeneration
Prepilin peptidasePrepilin peptidase
Caspase 14Caspase 14
PlasmepsinPlasmepsin
Caspase 3Caspase 3
Caspase 8Caspase 8
NeurodegenerationNeurodegeneration
PlasmodiumPlasmodium
Caspase 10Caspase 10
Caspase 6Caspase 6
RhizopuspepsinRhizopuspepsin
Beta-secretase 1Beta-secretase 1
Beta-secretase 1Beta-secretase 1
PenicillopepsinPenicillopepsin
MucorpepsinMucorpepsin
Picornain 3CPicornain 3C
EndothiapepsinEndothiapepsin
RhodotorulapepsinRhodotorulapepsin
ProteaseProtease
Acidic proteaseAcidic protease
Aspartic proteaseAspartic protease
Caspase 5Caspase 5
Retroviral aspartyl proteaseRetroviral aspartyl protease
Glutamic proteaseGlutamic protease
Aspergillopepsin IAspergillopepsin I
Proteases in angiogenesisProteases in angiogenesis
Aspartic proteaseAspartic protease
Caspase 4Caspase 4
Caspase 2Caspase 2
Chloroplast DNAChloroplast DNA
PRNPPRNP
Soy sauceSoy sauce
TransferrinTransferrin
Protein (nutrient)Protein (nutrient)
CaspaseCaspase
NepenthesNepenthes
SoybeanSoybean
Liosta Bithmhóilíní - VicipéidLiosta Bithmhóilíní - Vicipéid
Proteasome endopeptidase complexProteasome endopeptidase complex
Signal peptide peptidaseSignal peptide peptidase
Discovery and development of direct thrombin inhibitorsDiscovery and development of direct thrombin inhibitors
Cathepsin DCathepsin D
Protein metabolismProtein metabolism
Caspase 8Caspase 8
Cysteine proteaseCysteine protease
Protein primary structureProtein primary structure
Active siteActive site
Dipeptidyl peptidase-4Dipeptidyl peptidase-4
ProteaseProtease
CaseinCasein
Hookworm infectionHookworm infection
MukorpepsinMukorpepsin
Aspergillus fumigatusAspergillus fumigatus
CaspaseCaspase
PlasmodiumPlasmodium
PepsinPepsin
Cholecystokinin B receptorCholecystokinin B receptor
Cathepsin ACathepsin A
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation Science
Aspartic Acid ProteasesAspartic AcidPepstatinsAspartic Acid EndopeptidasesProtease InhibitorsEndopeptidasesNorleucinePeptide HydrolasesRhizopusMucorAmino Acid SequenceCathepsin DAspergillus oryzaeMolecular Sequence DataPepsin AHydrogen-Ion ConcentrationCathepsin EChymosinMitosporic FungiHIV ProteaseAmino AcidsCathepsinsAspergillus nigerSaccharomycopsisNitrophenolsPepsinogensSerine EndopeptidasesBinding SitesEpoxy CompoundsDiazonium CompoundsCladosporiumAspergillusAzo CompoundsXylarialesBase SequenceMutagenesis, Site-DirectedKineticsMolecular WeightPectobacterium carotovorumEncyclopedias as Topic2S Albumins, PlantCastor BeanFusariumTrichothecenesMycotoxinsTriticumZearalenonePlant DiseasesCerealsalpha-SynucleinParkinson DiseaseTremorSynucleinsSubstantia NigraNeurodegenerative Diseases
Aspartic acid proteases in yeast - DTU Research DatabaseAspartic acid proteases in yeast - DTU Research Database
Aspartic protease - WikipediaAspartic protease - Wikipedia
Protease LASSO Screening Libraries / Protease Libraries / Targeted and Focused Screening Libraries | Life ChemicalsProtease LASSO Screening Libraries / Protease Libraries / Targeted and Focused Screening Libraries | Life Chemicals
A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid ...A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid ...
Cell-free production of integral membrane aspartic acid proteases reveals zinc-dependent methyltransferase activity of the...Cell-free production of integral membrane aspartic acid proteases reveals zinc-dependent methyltransferase activity of the...
Protease and Phosphatase Inhibitors | Thermo Fisher Scientific - CAProtease and Phosphatase Inhibitors | Thermo Fisher Scientific - CA
Protease and Phosphatase Inhibitor Tablets | Thermo Fisher Scientific - JPProtease and Phosphatase Inhibitor Tablets | Thermo Fisher Scientific - JP
Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in...Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in...
MEDLINE - Resultado p gina 1 MEDLINE - Resultado p gina 1
MEDLINE - Resultado p gina 1 MEDLINE - Resultado p gina 1
Neurodegeneration - WikipediaNeurodegeneration - Wikipedia
HIV ProteaseHIV Protease
Serine proteaseSerine protease
Amyloid precursor protein secretase - WikipediaAmyloid precursor protein secretase - Wikipedia
Neurodegeneration - WikipediaNeurodegeneration - Wikipedia
What are protein hydrolyzing enzymes known as? | Reference.comWhat are protein hydrolyzing enzymes known as? | Reference.com
test #8 3.21 Flashcards by Nashid Chaudhury | Brainscapetest #8 3.21 Flashcards by Nashid Chaudhury | Brainscape
PepsinPepsin
Neutralizing monoclonal antibody against Dickkopf2 impairs lung cancer progression via activating NK cells | Cell Death...Neutralizing monoclonal antibody against Dickkopf2 impairs lung cancer progression via activating NK cells | Cell Death...
Exam 4 - Antivirals (Medchem-Stahelin) Flashcards by | BrainscapeExam 4 - Antivirals (Medchem-Stahelin) Flashcards by | Brainscape
Generic Caspase Activity Assay Kit (Fluorometric - Red) (ab112131) | AbcamGeneric Caspase Activity Assay Kit (Fluorometric - Red) (ab112131) | Abcam
Caspase Family Colorimetric Substrate Kit Plus (ab102486) | AbcamCaspase Family Colorimetric Substrate Kit Plus (ab102486) | Abcam
Autophagic and Apoptotic Effects of HDAC Inhibitors on Cancer CellsAutophagic and Apoptotic Effects of HDAC Inhibitors on Cancer Cells
Inhibitors of IAP - Genentech, Inc.Inhibitors of IAP - Genentech, Inc.
β-Secretase Cleavage of Alzheimers Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE | Scienceβ-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE | Science
Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis ) reveal substantial intra-family gene...Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis ) reveal substantial intra-family gene...
CASP14 gene - Genetics Home Reference - NIHCASP14 gene - Genetics Home Reference - NIH
CASP7 | Cancer Genetics WebCASP7 | Cancer Genetics Web
CASP8 Gene - GeneCards | CASP8 Protein | CASP8 AntibodyCASP8 Gene - GeneCards | CASP8 Protein | CASP8 Antibody
CASP8 | Cancer Genetics WebCASP8 | Cancer Genetics Web
CASP5 Gene - GeneCards | CASP5 Protein | CASP5 AntibodyCASP5 Gene - GeneCards | CASP5 Protein | CASP5 Antibody
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation Science
Aspartic Acid ProteasesAspartic AcidPepstatinsAspartic Acid EndopeptidasesProtease InhibitorsEndopeptidasesNorleucinePeptide HydrolasesRhizopusMucorAmino Acid SequenceCathepsin DAspergillus oryzaeMolecular Sequence DataPepsin AHydrogen-Ion ConcentrationCathepsin EChymosinMitosporic FungiHIV ProteaseAmino AcidsCathepsinsAspergillus nigerSaccharomycopsisNitrophenolsPepsinogensSerine EndopeptidasesBinding SitesEpoxy CompoundsDiazonium CompoundsCladosporiumAspergillusAzo CompoundsXylarialesBase SequenceMutagenesis, Site-DirectedKineticsMolecular WeightPectobacterium carotovorumEncyclopedias as Topic2S Albumins, PlantCastor BeanFusariumTrichothecenesMycotoxinsTriticumZearalenonePlant DiseasesCerealsalpha-SynucleinParkinson DiseaseTremorSynucleinsSubstantia NigraNeurodegenerative Diseases
ProteinaseSerineResiduesPeptidase familyCatalyticProteinsRetroviralAmino acidsSuperfamiliesCleavesEndopeptidasesPeptideCleavageEukaryoticSpecificityInhibitionImportantPositionCaspasesSerine ProteaseFamily of cysteine proteasesEnzymesEnzymeSubstrateSpecific proteaseTransmembrane aspartic proteaseAspartatePancreaticPepsinGlutamic acidExtracellularNucleicTargetsTypes of proteasesBeta-secretaseRole of proteasesPeptidaseBACE1PepstatinAspartyl proteasesOrganismsMediatesPolypeptide chainEDTAIrreversibleDegradationPeptidesCaspase family
Proteinase1
  • Only a few aspartic acid proteases are known from the yeast Saccharomyces cerevisiae, proteinase A, Bar1, yapsin 1-7. (dtu.dk)
Serine3
Residues4
Peptidase family1
Catalytic1
  • In modern-day enzymes, although the three-dimensional structures are very similar, the amino acid sequences are more divergent, except for the catalytic site motif, which is very conserved. (wikipedia.org)
Proteins1
Retroviral1
Amino acids1
Superfamilies1
Cleaves1
Endopeptidases1
Peptide2
Cleavage1
  • It also activates platelets by cleavage of the N-terminus of protease-activated-receptors in their membranes, further contributing to the coagulation process. (lifechemicals.com)
Eukaryotic1
Specificity1
  • The Yapsins are unique among the aspartic acid proteases because of their specificity for mono- and dibasic sites. (dtu.dk)
Inhibition1
Important1
Position1
Caspases11
Serine Protease6
Family of cysteine proteases1
Enzymes19
  • In modern-day enzymes, although the three-dimensional structures are very similar, the amino acid sequences are more divergent, except for the catalytic site motif, which is very conserved. (wikipedia.org)
  • Proteases and phosphatases are important enzymes in a variety of biochemical pathways in living cells. (thermofisher.com)
  • All living organisms contain proteolytic enzymes (proteases and peptidases). (thermofisher.com)
  • Thus, while numerous compounds have been identified and used to inactivate or block these enzymes, no single chemical is effective for all types of proteases and phosphatases (see table). (thermofisher.com)
  • Proteases are a ubiquitous class of enzymes that hydrolyze protein peptide bonds. (thermofisher.com)
  • Other important digestive proteases are the pancreatic enzymes trypsin and chymotrypsin . (bionity.com)
  • Serine proteases participate in a wide range of functions in the body, including blood clotting , immunity , and inflammation , as well as contributing to digestive enzymes in both prokaryotes and eukaryotes. (bionity.com)
  • Protein hydrolyzing enzymes are known as protease. (reference.com)
  • This hydrolytic activity is given by a family of enzymes and zymogens present in the cell, called widely 'proteases', with the purpose to hydrolyze the peptide bond [7, (thefreedictionary.com)
  • Proteases of fungal origin can be produced cost effectively, have an advantage faster production, the ease with which the enzymes can be modified and mycelium can be easily removed by filtration. (scielo.br)
  • The production of proteases has been carried out using submerged fermentation, but conditions in solid state fermentation lead to several potential advantages for the production of fungal enzymes. (scielo.br)
  • This review focuses on the production of fungal proteases, their distribution, structural-functional aspects, physical and chemical parameters, and the use of these enzymes in industrial applications. (scielo.br)
  • Microbial proteases are among the most important hydrolytic enzymes and have been studied extensively. (scielo.br)
  • Fungal proteases have attracted the attention of environmental biotechnologists because fungi can grow on low cost substrates and secrete large amount of enzymes into culture medium which could ease downstream processing ( Anitha and Palanivelu, 2013 ). (scielo.br)
  • In this present review, some aspects of fungal proteolytic enzymes are discussed, with reference to the production of protease, their distribution and their industrial applications. (scielo.br)
  • Proteases are classified as peptide hydrolases or peptidases (EC 3.4) and constitute a large family of enzymes, divided into endopeptidases (EC 3.4.21-99) and exopeptidases (EC 3.4.11-19), classified according to the position of the peptide bond to be cleaved. (scielo.br)
  • The crystal structure of a mammalian aspartic proteinase indicates that interactions with substrate may be more extensive on the prime side of the active site cleft than in the fungal enzymes and involve Tyr189 and the loop 290 to 295, perhaps contributing to the transpeptidase activity of pepsin and the specificity of the renins. (rcsb.org)
  • Proteases that catalyse the hydrolysis of peptide bonds constitute the most abundant group of enzymes. (embopress.org)
  • In addition to this substitution, a number of viral enzymes (also found in adenovirus and some picornaviruses) utilize glutamic acid, instead of the catalytic aspartic acid ( 9 , 22 ). (asm.org)
Enzyme5
  • The HIV Protease is an enzyme with two symmetrical subunits. (middlebury.edu)
  • Located very near one another near the heart of the enzyme, these three key amino acids each play an essential role in the cleaving ability of the proteases. (bionity.com)
  • About.com Chemistry specifically defines protease as an enzyme that initiates the hydrolysis of a peptide bond to form polypeptide chains. (reference.com)
  • The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. (genecards.org)
  • A panel of eleven human cancer cell lines, glioblastoma and carcinoma, were exposed to serial dilutions of ascorbic acid (5-100 mmol/L). The purpose of this study was to analyse the impact of catalase, an important hydrogen peroxide-detoxifying enzyme, on the resistance of cancer cells to ascorbic acid mediated oxidative stress. (biomedcentral.com)
Substrate5
Specific protease2
Transmembrane aspartic protease2
Aspartate1
Pancreatic1
  • The polyprotein of infectious pancreatic necrosis virus (IPNV), a birnavirus, is processed by the viral protease VP4 (also named NS) to generate three polypeptides: pVP2, VP4, and VP3. (asm.org)
Pepsin3
  • Pepsin is expressed as a pro-form zymogen, pepsinogen , whose primary structure has an additional 44 amino acids . (bionity.com)
  • Pepsin will digest up to 20% of ingested carbon bonds by cleaving preferentially after the N-terminal of aromatic amino acids such as phenylalanine and tyrosine . (bionity.com)
  • Therefore processing of Shh in the normal stomach is hormonally regulated, acid-dependent, and mediated by the aspartic protease pepsin A. Moreover parietal cell atrophy, a known pre-neoplastic lesion, correlates with loss of Shh processing. (biomedsearch.com)
Glutamic acid1
Extracellular4
  • The human pathogenic bacterium group A Streptococcus produces an extracellular cysteine protease [streptococcal pyrogenic exotoxin B (SpeB)] that is a critical virulence factor for invasive disease episodes. (pnas.org)
  • GAS isolates produce a highly conserved extracellular cysteine protease known as streptococcal pyrogenic exotoxin B (SpeB) (reviewed in ref. 5 ). (pnas.org)
  • Proteases are required for many cellular functions, including cellular repair and the digestion of extracellular material. (thermofisher.com)
  • Furthermore, due to the accumulation of lactic acid from Warburg's effect, the acidification of extracellular microenvironment favors the progression and metastases of tumor via upregulation of metallo-proteinase and cysteine proteinase activity and secretion [ 3 ]. (hindawi.com)
Nucleic2
  • Receptors within the cytoplasm can bind to virus-derived signature molecules, such as different types of nucleic acid and signal that infection is present. (portlandpress.com)
  • Nucleic Acids Research , 26 (8), 2008-2015. (elsevier.com)
Targets3
Types of proteases1
Beta-secretase2
Role of proteases1
  • Characterization of the role of proteases in disease and also their precise mechanism of action was essential for these drug discoveries. (embopress.org)
Peptidase1
  • A representative group of novel venom transcripts exhibiting similarity to lysosomal acid lipase were identified from the E. coloratus transcriptome, whilst novel metallopeptidases exhibiting similarity to neprilysin and dipeptidyl peptidase III were identified from E. p. leakeyi and E. coloratus respectively. (biomedcentral.com)
BACE12
Pepstatin1
Aspartyl proteases1
Organisms3
Mediates2
Polypeptide chain3
EDTA1
Irreversible1
Degradation1
  • An Internal Standard-Assisted Synthesis and Degradation Proteomic Approach Reveals the Potential Linkage between VPS4B Depletion and Activation of Fatty Acid β-Oxidation in Breast Cancer Cells. (umn.edu)
Peptides1
  • Peptides may be further digested by other proteases (in the duodenum ) and eventually absorbed by the body. (bionity.com)
Caspase family2
Aspartic acid proteases in yeast - DTU Research Database
Aspartic acid proteases in yeast - DTU Research Database (orbit.dtu.dk)
Aspartic protease - Wikipedia
Aspartic protease - Wikipedia (en.wikipedia.org)
Neurodegeneration - Wikipedia
Neurodegeneration - Wikipedia (en.wikipedia.org)
HIV Protease
HIV Protease (community.middlebury.edu/~sontum/)
Cell-free production of integral membrane aspartic acid proteases reveals zinc-dependent methyltransferase activity of the...
Cell-free production of integral membrane aspartic acid proteases reveals zinc-dependent methyltransferase activity of the... (chem.wisc.edu)
Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis ) reveal substantial intra-family gene...
Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis ) reveal substantial intra-family gene... (bmcgenomics.biomedcentral.com)
Genetic Mechanisms Underlying the Pathogenicity of Cold-Stressed Salmonella enterica Serovar Typhimurium in Cultured Intestinal...
Genetic Mechanisms Underlying the Pathogenicity of Cold-Stressed Salmonella enterica Serovar Typhimurium in Cultured Intestinal... (aem.asm.org)
Charles S. Craik, PhD | School of Pharmacy | UCSF
Charles S. Craik, PhD | School of Pharmacy | UCSF (pharmacy.ucsf.edu)
MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis | Molecular and Cellular...
MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis | Molecular and Cellular... (mcb.asm.org)
CASP12 Antibody (Center) - Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) WB, IHC-P, FC, IF, E - Buy Now! |Abgent
CASP12 Antibody (Center) - Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) WB, IHC-P, FC, IF, E - Buy Now! |Abgent (abgent.com)
Thermo Scientific™ Halt™ Protease Inhibitor Cocktails
Thermo Scientific™ Halt™ Protease Inhibitor Cocktails (fishersci.ca)
Characterization of SGN-CD123A, A Potent CD123-Directed Antibody-Drug Conjugate for Acute Myeloid Leukemia | Molecular Cancer...
Characterization of SGN-CD123A, A Potent CD123-Directed Antibody-Drug Conjugate for Acute Myeloid Leukemia | Molecular Cancer... (mct.aacrjournals.org)
Human Apoptosis Array C1 | ABIN625525
Human Apoptosis Array C1 | ABIN625525 (antikoerper-online.de)
ASMscience | Adhesins Involved in Attachment to Abiotic Surfaces by Gram-Negative Bacteria
ASMscience | Adhesins Involved in Attachment to Abiotic Surfaces by Gram-Negative Bacteria (asmscience.org)
Allosteric regulation of rhomboid intramembrane proteolysis | The EMBO Journal
Allosteric regulation of rhomboid intramembrane proteolysis | The EMBO Journal (emboj.embopress.org)
Community Academic Profiles - Faculty & Researchers - Stanford Medicine
Community Academic Profiles - Faculty & Researchers - Stanford Medicine (med.stanford.edu)
CASP12 / Caspase 12 - LSBio
CASP12 / Caspase 12 - LSBio (lsbio.com)
Why Caspases are the executioners of apoptosis? | AG Scientific Blog
Why Caspases are the executioners of apoptosis? | AG Scientific Blog (agscientific.com)
Stefani Thomas - Research Output - Experts@Minnesota
Stefani Thomas - Research Output - [email protected] (experts.umn.edu)
Apoptosis: Molecular Mechanisms
Apoptosis: Molecular Mechanisms (els.net)
US6320029B1 - Methods of production and use of liquid formulations of plasma proteins - Google Patents
US6320029B1 - Methods of production and use of liquid formulations of plasma proteins - Google Patents (patents.google.com)
Cytotoxicity Assays - what your cells don't like | BMG LABTECH
Cytotoxicity Assays - what your cells don't like | BMG LABTECH (bmglabtech.com)
Caspase-3 Antibody - Bicoare Medical
Caspase-3 Antibody - Bicoare Medical (biocare.net)
Characterization of two Lactococcus lactis zinc membrane proteins, Llmg_0524 and Llmg_0526, and role of Llmg_0524 in cell wall...
Characterization of two Lactococcus lactis zinc membrane proteins, Llmg_0524 and Llmg_0526, and role of Llmg_0524 in cell wall... (bmcmicrobiol.biomedcentral.com)
Astragalus polysaccharide combined with 10-hydroxycamptothecin inhibits metastasis in non-small cell lung carcinoma cell lines...
Astragalus polysaccharide combined with 10-hydroxycamptothecin inhibits metastasis in non-small cell lung carcinoma cell lines... (spandidos-publications.com)
Discriminatory simplex and multiplex PCR for four species of the genus Sclerotinia<...
Discriminatory simplex and multiplex PCR for four species of the genus Sclerotinia<... (pennstate.pure.elsevier.com)
Death, autoantigen modifications, and tolerance | Arthritis Research & Therapy | Full Text
Death, autoantigen modifications, and tolerance | Arthritis Research & Therapy | Full Text (arthritis-research.biomedcentral.com)
Protease-Activated Drug Development
Protease-Activated Drug Development (thno.org)
Study on changes of Fas, p-BAD and caspase-8 expression in acute myocardial infarction rats treated by Guanxin decoction
Study on changes of Fas, p-BAD and caspase-8 expression in acute myocardial infarction rats treated by Guanxin decoction (alliedacademies.org)
Robert Mackin, PhD - Research Output - Creighton University
Robert Mackin, PhD - Research Output - Creighton University (creighton.pure.elsevier.com)
Find Research Outputs - Manipal Academy of Higher Education, Manipal, India
Find Research Outputs - Manipal Academy of Higher Education, Manipal, India (manipal.pure.elsevier.com)
Molecular Genetics - Research Output - University of Texas Southwestern Medical Center
Molecular Genetics - Research Output - University of Texas Southwestern Medical Center (utsouthwestern.pure.elsevier.com)
In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts<...
In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts<... (pure.udem.edu.mx)
BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid<...
BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid<... (discovery.dundee.ac.uk)