Aspartate Kinase

Homoserine Dehydrogenase

Threonine

Aspartate Aminotransferases

Influenza, Human

Influenza A Virus, H1N1 Subtype

Influenza A virus

Influenza Vaccines

California

Influenza A Virus, H3N2 Subtype

Influenza in Birds

Amino acid kinase - Wikipedia

KEGG BRITE: Enzymes - Vibrio gazogenes

ASMscience | Epigenetic Phosphorylati

SAUSA300 1225 - AureoWiki

Search Results

Arsenic in the structure of Crystal Structure Of the H277N Mutant of Aspartate Semialdehyde Dehydrogenase From Haemophilus...

Chain A, Aspartate beta-semialdehyde dehydrogenase (Streptococcus pneumoniae) | Protein Target - PubChem

Lysine biosyntheis | LAMP

CATH Superfamily 3.30.70.260

UniProt: Q9ZCI7

On the origin and evolution of biosynthetic pathways: integrating microarray data with structure and organization of the Common...

Structure and Regulation of Aspartate Pathway Enzymes and Deuteration Effects on Protein Structure - OpenThesis

NWMN 1305 - AureoWiki

LYZ Gene - GeneCards | LYSC Protein | LYSC Antibody

3M 2094N COMPRESSION SYS C2L Box of 1 Each - Oz Medical Supply

Nội Quy Box Ứng Dụng

Bio chemistry II complete notes ebook free download doc

CDD Conserved Protein Domain Family: ACT HSDH-Hom

UniProt/TrEMBL: Q82EQ5 STRAW

fortran - Molecular Dynamics: Diffusion with PBC - Computational Science Stack Exchange

lysC - 196627 v2020 s21 dsRNA - Abasy Atlas

10L refill - LAUNDRY DETERGENT 2X CONCENTRATED | Baleco

Best 25+ Hilfe bei durchfall ideas on Pinterest | Durchfall, Durchfall homöopathie and Durchfall hausmittel

Mr William Garrett | Alexandra Hospital | Spire Healthcare

L-Threonine, L-arginyl-L-a-glutamyl-L-a-aspartyl-L-seryl-L-histidyl-L-tryptophyl-L-leucyl-L-asparaginyl-L-cysteinyl-L-arginyl-...

Lehning homéopathie - climaxol, santaherba, L72, Complexe

EC 2.7.4.22

Global L-Threonine Sales Market Report 2020 : ReportsnReports

Allosteric enzymes | definition of allosteric enzymes by Medical dictionary

Biodiesel Production: Technology Barry Latham, M.A.Ed. Biodiesel Production & Curriculum Chemistry & Physics Instructor Chicago...

Escherichia coli NADH dehydrogenase I, a minimal form of the mitochondrial complex I | Biochemical Society Transactions

Homoserine

Rangelia

Homoserine dehydrogenase

CAMK2B

ACT domain

Threonine

Pattern recognition receptor

Lysine

Atipamezole

Fructose-asparagine

Equine exertional rhabdomyolysis

LuxR-type DNA-binding HTH domain

Acquired non-inflammatory myopathy

Histidine phosphotransfer domain

Two-component regulatory system

Amino acid synthesis

DLG3

PTK2B

DLG4

GRIN2A

Camilla Bellone

GRIA1

CAMK2G

Aspartate kinase

CDK-activating kinase

Amino acid kinase

Signal transduction

Nucleoside-phosphate kinase

Adenylate kinase

Phosphoglycerate kinase

Glycolysis

Amyloid beta

Neurotoxin

Threonine

Pyridoxal phosphate

Liver function tests

Ligand-gated ion channel

Lisdexamfetamine

Terminal deoxynucleotidyl transferase

Caspase-activated DNase

Metabolism

Sodium-potassium pump

GABRA4

Metabotropic glutamate receptor

Histone methyltransferase

HSPA8

Index of biochemistry articles

ST motif

Chromosome 6

Excitatory amino acid transporter 3

Cholestasis

Spatial memory

GRIA4

Ribonucleotide

Coagulation factor II receptor

Coenzyme A

Lactate11

• The primary reference measurement procedures (PRMPs) for the international standardization of catalytic concentration measurements of α-amylase, alanine aminotransferase, aspartate aminotransferase (AST), creatine kinase (CK), γ-glutamyltransferase and lactate dehydrogenase have been performed in reference laboratories for several years. (elsevier.com)
• Various enzymes, such as gelatinase-B, alanine transaminase, creatine kinase, acid phosphatase, aspartate transaminase and lactate dehydrogenase, are used as preferred biomarkers for the diagnosis of numerous ailments, including renal disease, cancer and rheumatoid arthritis. (imarcgroup.com)
• Abnormal levels of at least 1 of the following enzymes: creatine kinase (CK), aldolase, lactate dehydrogenase, aspartate aminotransaminase (AST), alanine aminotransferase (ALT), based on central laboratory results b. (who.int)
• Subcutaneous injection of ISO (85 mg/kg in saline) for two consecutive days caused a significant increase in serum cardiac marker enzymes (creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate transaminase (AST)), cTnI, serum TC, and TG levels. (greenmedinfo.com)
• M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications. (cocites.com)
• Increased levels of alanine aminotransferase, aspartate aminotransferase, creatine kinase MB activity, and lactate dehydrogenase were the most common laboratory abnormalities. (polymerelektronik.org)
• Ethanolic Z. officinale (ZO) extract (200 mg/kg) pretreatment for 20 days in isoproterenol (ISO)-treated rats significantly increased the levels of endogenous myocardial antioxidants (catalase, superoxide dismutase and tissue glutathione), decreased the levels of serum marker enzymes (lactate dehydrogenase, creatine kinase, aspartate transaminase and alanine transaminase) and increased myocardial lipid peroxides. (who.int)
• The protective effects of aloin against DOX-induced toxicity were evident as a statistically significant inhibition of a rise in the biochemical markers of myocardial damage including lactate dehydrogenase (LDH), creatinine kinase-myocardial band (CK-MB), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). (greenmedinfo.com)
• Diagnosis of COVID-19 can be carried out by several ways like identifying the increased level of lactate dehydrogenase, creatinine kinase, alanine and aspartate dehydrogenase in blood. (ihrjournal.com)
• Heart function: lactate dehydrogenase LDH, creatine kinase and other CK, aspartate aminotransferase AST, etc. ★ blood lipids project: total cholesterol CHO, high-density lipoprotein HDLC, low-density lipoprotein LDLC, triglyceride TG, etc. (kindlemedical.com)
• Furthermore, RGP1-1 possessed strong antioxidant activity in vitro and in vivo, RGP1-1 could decrease cardiomyocyte apoptosis and myocardium fibrosis of mice in histopathology and it could decrease significantly the serum levels of cardiac troponin (cTnI), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), malondialdehyde (MDA). (biomedcentral.com)

NMDA6

• Consistent with a prior report indicating that N -methyl- d -aspartate (NMDA) receptor (NMDAR) activation can promote steroid production, we observed that d -2-amino-5-phosphonovalerate (APV), a competitive NMDAR antagonist, blocked the effects of 60 m m ethanol on staining. (jneurosci.org)
• We seek to define the activation pathway, modulatory mechanisms and structure-function relationships of the N-methyl-D-aspartate (NMDA) receptor to better understand the roles played by this protein in the central nervous system. (buffalo.edu)
• We are interested in understanding the roles of glutamate receptors and in particular N-methyl-D-aspartate (NMDA) and glutamate delta receptors in the central nervous system. (creighton.edu)
• In further experiments characterizing two phenomena, the increased Fos expression in the Vo was mediated by an additive activation of both mGluR1 and mGluR5, which required the activation of N-methyl-D-aspartate (NMDA) receptors, protein kinase C (PKC) and extracellular signal-regulated kinase (ERK). (molcells.org)
• Palmitoylation within the first cluster on a membrane-proximal region increases tyrosine phosphorylation of tyrosine-based internalization motifs by Src family protein tyrosine kinases, leading to enhanced stable surface expression of NMDA receptors. (elsevier.com)
• Damage to the hippocampus (HPC) using the excitotoxin N-methyl-D-aspartate (NMDA) can cause retrograde amnesia for contextual fear memory space. (bioscience2006.org)

Transaminase4

• here, glutamic oxaloacetic transaminase (GOT)/aspartate aminotransferase (AST) because of its higher muscular activity shows a stronger response compared with glutamic pyruvate transaminase (GPT)/alanine aminotransferase (ALT). (aerzteblatt.de)
• Enzymes indicative of muscle damage, including serum creatinine kinase (CK) and aspartate transaminase (AST) are increased, whereas whole blood selenium and vitamin E concentrations are low. (ucdavis.edu)
• Increased levels of aspartate transaminase, creatinine kinase and gamma-glutamyl transferase were consistent with the presence of liver muscle and central nervous dysfunction and reflected the generalized nature of the intoxication. (flockandherd.net.au)
• Serologic testing yielded mildly increased serum creatine kinase (187 U/L, reference range 40-171 U/L) and alanine transaminase (50 U/L, reference range 10-40 U/L) concentrations. (aurametrix.com)

Creatinine4

• A diagnosis of toxic shock syndrome was considered and was supported by laboratory findings of thrombocytopenia (70,000/mm((3))), renal insufficiency (creatinine level = 2.8 mg/dL, urea nitrogen level = 40 mg/dL), hypocalcemia (Ca = 5.9 mg/dL), and elevated levels of creatine kinase (12,000 U/L) and aspartate aminotransferase (367 U/L). Staphylococcus aureus was isolated from two tracheal aspirates obtained on the day of admission. (cdc.gov)
• There was a significant increase in the level of creatinine kinase (ck) and ck-mb. (utsuwayaakane.com)
• To have a raised creatinine kinase (ck). (utsuwayaakane.com)
• In Experiment 2, rhIGF-1 treated pigs had reduced blood creatine kinase, creatinine, potassium and aspartate aminotransferase levels, with no effects on organ weights (except increased spleen weight), blood chemistry values, clinical variables or NEC. (regionh.dk)

Receptors2

• Finally, the structure provides a basis for rationalizing the effects of kinase mutations in FGF receptors that lead to developmental disorders in nematodes and humans. (embl-heidelberg.de)
• William Baldridge, PhD: Functional evidence for D-serine inhibition of non-N-methyl-D-aspartate ionotropic glutamate receptors in retinal neurons. (glaucoma.org)

Serum9

• Lew serum creatine kinase values in contraceptive steroid users. (utsuwayaakane.com)
• The level of creatine kinase (ck) in serum was determined by an. (utsuwayaakane.com)
• Serum levels of creatine kinase typically are within the reference range. (utsuwayaakane.com)
• Subtle abnormalities in the serum creatine kinase level, aspartate aminotransferase, and serum bicarbonate led us to perform a muscle biopsy, which showed type I myofiber atrophy, increased lipid content, and reduced cytochrome c oxidase activity. (wordpress.com)
• 0001). The serum creatine kinase level also was abnormally elevated in 22 (47%) of 47 patients with autism. (wordpress.com)
• Serum elevations of ALT activity are rarely observed, except in parenchymal liver disease, since ALT is a more liver-specific enzyme than aspartate aminotransferase (AST). (cdc.gov)
• Description: A sandwich ELISA kit for detection of Mitogen Activated Protein Kinase 9 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
• Serum bilirubin, aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and C-reactive protein levels were normal. (aurametrix.com)
• Description: A sandwich quantitative ELISA assay kit for detection of Rat Rho Associated Coiled Coil Containing Protein Kinase 2 (Rock2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (hiv-pharmacogenomics.org)

Enzymes6

• Blood tests often reveal low levels of vitamin E and mildly elevated levels of two muscle enzymes in horses with EMND: aspartate aminotransferase and creatine kinase. (pacificcrestequine.com)
• Liver enzymes, i.e. aspartate aminotransferase, alanine aminotransferase and gamma glutamyltranspeptidase, were slightly elevated prior to therapy. (iospress.com)
• Liver enzymes were elevated with alanine aminotransferase at 1260 U/L, aspartate aminotransferase at 499 U/L and gamma glutamyltranspeptidase 284 U/L. Creatine kinase was elevated at 405 U/L, while bilirubin and renal function parameters were within normal levels. (iospress.com)
• The kinase domains that define this group of enzymes contain 12 conserved subdomains that fold into a common catalytic core structure, as revealed by the 3-dimensional structures of several protein-serine kinases. (embl-heidelberg.de)
• A classification scheme can be founded on a kinase domain phylogeny, which reveals families of enzymes that have related substrate specificities and modes of regulation. (embl-heidelberg.de)
• The AGC kinases regulate critical processes including metabolism, cell growth, proliferation, survival and differentiation, hence deregulation of these enzymes is a causative factor in different diseases such as cancer and diabetes. (eu.org)

Blood creatine kinase1

• Physical exercise or strenuous sporting activities can increase blood creatine kinase (CK) levels something to bear in mind in patients with suspected statin-associated muscle symptoms. (aerzteblatt.de)

Proteins5

• In RLKs, extracellular domains are involved in signal perception and protein-protein interactions 12 while the intracellular kinase domain transduces signals to substrate proteins. (nature.com)
• The eukaryotic protein kinases make up a large superfamily of homologous proteins. (embl-heidelberg.de)
• We show that mPins (mammalian homologue of Drosophila melanogaster partner of inscuteable) interacts with SAP102 and PSD-95 (two PDZ proteins present in neurons), and functions in the formation of the NMDAR -MAGUK (N-methyl-D-aspartate receptor -membrane-associated guanylate kinase) complex. (elsevier.com)
• The Receptor for Activated C Kinase 1 (RACK1) is a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and shares significant homology to the β subunit of G-proteins (Gβ). (ul.ie)
• A report by Zheng and coworkers recommended that retention of TACO, a tryptophan aspartate-containing coating proteins on phagosomes, impairs fusion of phagosomes and lysosomes in macrophages contaminated with (7). (cdkkinase.com)

Phosphorylation11

• Aspartate kinase or aspartokinase (AK) is an enzyme that catalyzes the phosphorylation of the amino acid aspartate. (wikipedia.org)
• Following inhibition of ASPH activity, phosphorylation of glycogen synthase kinase 3β and p16 expression were increased to promote senescence, whereas cyclin D1 and proliferating cell nuclear antigen were decreased to reduce cell proliferation. (elsevier.com)
• In vivo experiments demonstrated that small molecule inhibitor treatment of HCC bearing mice resulted in significant dose-dependent reduced tumor growth, induced phosphorylation of glycogen synthase kinase 3β, enhanced p16 expression in tumor cells, and promoted cellular senescence. (elsevier.com)
• Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA. (pdbj.org)
• AspK catalyzes the phosphorylation of L-aspartate to produce 4-phospho-L-aspartate while DapDC participates in the last step of lysine biosynthesis, the conversion of meso-2,6-diaminoheptanedioate to L-lysine. (umbc.edu)
• The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases. (cocites.com)
• A casual decision made one evening in 1976, in a bar near the Biochemistry Department at the University of Dundee, led me to start my personal research journey by following up a paper that suggested that acetyl-CoA carboxylase (ACC) (believed to be a key regulatory enzyme of fatty acid synthesis) was inactivated by phosphorylation by what appeared to be a novel, cyclic AMP-independent protein kinase. (portlandpress.com)
• Regulation of kinase activity is mainly achieved through phosphorylation of the activation or T-loop, located in the C-lobe and connected to the N-lobe through the alpha-C helix. (eu.org)
• Rad53 protein, the yeast orthologue of the human checkpoint kinase Chk2, presents two highly conserved phosphorylatable threonine residues (T354 and T358) in the activation domain, whose phosphorylation is critical to allow the activation of the kinase. (unimi.it)
• In this study we found that Rad53 protein variants in which alanine and/or aspartate replace the threonine residues 354 and/or 358 do not retain kinase activity and do not undergo auto-phosphorylation, leading to defect in the checkpoint response and iper-sensitivity to DNA damage and DNA replication stress agents. (unimi.it)
• Here we show that cell cycle phosphorylation of the prototypical DDR mediator Saccharomyces cerevisiae Rad9 depends on cyclin-dependent kinase (CDK) complexes. (ul.ie)

Inhibition4

• Background Combined inhibition of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) complexes may be an efficient treatment for acute leukemia. (researchsquare.com)
• Schubert A, Koziol U, Cailliau K, Vanderstraete M, Dissous C, Brehm K (2014) Targeting Echinococcus multilocularis Stem Cells by Inhibition of the Polo-Like Kinase EmPlk1. (plos.org)
• Calmodulin kinase II inhibition protects against structural heart disease. (vanderbilt.edu)
• These data enable an estimation from the price of pyruvate development from aspartate around 1 mumol/min per kidney under circumstances of full 781661-94-7 IC50 PEPCK inhibition. (osi-930.com)

Mitogen-Activat1

• The protein expression degrees of p38 mitogen activated protein kinases (p38) and nuclear factor-k-gene binding (NF-κB) were assayed by western blotting. (ac.ir)

Aminotransferase levels2

• Increases in aminotransferase levels can be expected when the creatine kinase levels exceed 3x-4x ULN. (aerzteblatt.de)
• In this genetic association study of 3557 children, adolescents, and young adults receiving ALL therapy, variants in UGT1A1 and PNPLA3 were associated with hyperbilirubinemia and elevated alanine aminotransferase and aspartate aminotransferase levels, respectively. (cdc.gov)

Tyrosine kinase in4

• This phase II trial studies how well ABL001 works in treating patients with chronic myeloid leukemia who are on therapy with tyrosine kinase inhibitor. (clinicaltrials.gov)
• Giving ABL001 and tyrosine kinase inhibitor together may work better than tyrosine kinase inhibitor alone in treating patients with chronic myeloid leukemia. (clinicaltrials.gov)
• I. To determine the clinical activity of the combination of asciminib (ABL001) and a tyrosine kinase inhibitor (TKI) in patients with chronic myeloid leukemia (CML) in complete cytogenetic response (CCyR) but detectable BCR-ABL1 transcript. (clinicaltrials.gov)
• In this diagnostic study of 171 patients with advanced NSCLC and PE (104 tyrosine kinase inhibitor [TKI]-naive and 67 with acquired resistance to first- or second-generation EGFR-TKI therapy), PE-cfDNA had high sensitivity and specificity (both 97%) and better sensitivity (97% vs 74%) than plasma for the detection of sensitizing EGFR variants. (cdc.gov)

Creatine kinase levels1

• The mean creatine kinase levels of the patients were 1.354±840 U/L. Fifteen (100%) of the patients had muscle weakness, 14 (93.3%) had Gottron's papules and 12 (80%) patients had a heliotrope rash. (bakirkoymedj.org)

Regulates1

• Pyruvate kinase M2 regulates photoreceptor structure, function, and viability. (cocites.com)

Pathway5

• While mutations of the PI3KCA gene are rare in leukemia, events upstream of PI3K are commonly implicated in causing aberrant activation of this pathway, e.g. activating mutations of the receptor tyrosine kinases (RTKs), Fms-like tyrosine kinase 3 ( FLT3 ) and KIT receptor tyrosine kinase, BCR-ABL1 fusion gene, or activating mutations in NRas and KRas . (researchsquare.com)
• We also show that the HW1-mediated autophagic cell death occurs predominantly via the c-Jun NH 2 -terminal kinase pathway in a caspase-independent manner. (aacrjournals.org)
• This led me to define and name the AMP-activated protein kinase (AMPK) signalling pathway, on which I am still working 46 years later. (portlandpress.com)
• An important mechanism for increased cell survival in many cancers is mediated by the phosphatidylinositol-3-kinase (PI3-K)/Akt (protein kinase B) signaling pathway that is activated by receptor and oncogenic protein tyrosine kinases ( 2 ). (aacrjournals.org)
• creation from aspartate, illustrating a phosphoenolpyruvate carboxykinase (PEPCK)-3rd party pathway for the bicycling of pyruvate. (osi-930.com)

Residues4

• Two aspartate residues facilitate cation binding and nucleophilic attack . (wikipedia.org)
• Residues in the activation loop of FGFR1K appear to interfere with substrate peptide binding but not with ATP binding, revealing a second and perhaps more general autoinhibitory mechanism for receptor tyrosine kinases. (embl-heidelberg.de)
• They are related by virtue of their kinase domains (also known as catalytic domains), which consist of approximately 250-300 amino acid residues. (embl-heidelberg.de)
• Instead, this variant only consists of the first two core aromatic residues preceding this site in the other motif variants, and in this case the latter of these two aromatic residues is located at the C-terminal position of the kinase. (eu.org)

Inhibitor2

• U0126 is a potent and selective non-competitive inhibitor of MAP kinase kinase. (tocris.com)
• The decreased glucose tolerance caused by PX-866 was insensitive to the AMP-activated protein kinase inhibitor metformin but reversed by insulin and by the peroxisome proliferator-activated receptor-γ activator pioglitazone. (aacrjournals.org)

Inhibitors11

• The present structure provides a molecular basis for clarifying the known biochemical properties of CaMKKβ and for designing novel inhibitors targeting CaMkkβ and the related protein kinases. (semanticscholar.org)
• 14,15,16 Herein in Philadelphia chromosome positive (Ph+) BCP-ALL PI3K signaling has been shown to be involved in mutation-independent resistance to ABL-directed tyrosine kinase inhibitors 14 and recent preclinical data also suggest a role in Philadelphia chromosome negative (Ph-) BCP-ALL. (researchsquare.com)
• To determine the safety of the combination of asciminib and tyrosine kinase inhibitors. (clinicaltrials.gov)
• Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. (embl-heidelberg.de)
• Of these, the H series protein kinase inhibitors (1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7), N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H8) N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H89)) are frequently used to block signaling pathways in studies of cellular regulation. (embl-heidelberg.de)
• The conservation of the ATP-binding site of protein kinases allows evaluation of factors governing general selectivity of these inhibitors among kinases. (embl-heidelberg.de)
• These results should assist efforts in the design of protein kinase inhibitors with specific properties. (embl-heidelberg.de)
• Recent work shows that phosphatidylinositol-3-kinase (PI3-K) is coupled to the EGFR only in NSCLC cell lines expressing ErbB-3 and that EGFR inhibitors do not inhibit PI3-K signaling in these cells. (aacrjournals.org)
• Tyrosine kinase inhibitors with activity against vascular endothelial development aspect receptor 2 are actually standard treatment in most of sufferers with advanced renal cell carcinoma. (immune-source.com)
• Immunotherapy (eg interferon α) in combination with tyrosine kinase inhibitors is currently in clinical tests for treatment of chronic myeloid leukemia (CML). (cell-signaling-pathways.com)
• Irrespective of Sokal score the typical treatment for CML is normally tyrosine kinase inhibitors (TKIs). (cell-signaling-pathways.com)

Cyclin-depend3

• The present application provides bifunctional compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 8 (CDK8). (justia.com)
• Cyclin-dependent kinase is a kinase family integrating multiple signaling pathways to control either cell cycle or gene transcription. (justia.com)
• the Targeting Ligand is capable of binding to a targeted protein, such as a cyclin-dependent kinase (e.g. (justia.com)

Phosphatidylinositol 3-kina1

• The phosphatidylinositol 3-kinase (PI3K) / Akt / mammalian target of rapamycin (mTOR) signaling axis plays an important physiologic role in protein synthesis, gene transcription, cell growth and apoptosis. (researchsquare.com)

Levels6

• Maximal aspartate aminotransferase, alanine aminotransferase, and kinase levels were also significantly higher in patients with diffuse lesions. (ajnr.org)
• Extremely high levels of creatine kinase resulted from. (utsuwayaakane.com)
• in Australia in a 37-year-old man who had progressive facial, axial, and limb weakness, dysphagia, dysphonia, increased levels of creatine kinase and hepatic aminotransferases, and peripheral eosinophilia for 8 years. (cdc.gov)
• Collagen type 3, fibronectin, phosphorylated Ser/Thr protein kinase, phosphorylated glycogen synthase kinase-3 beta, glycogen synthase kinase-3 beta, nuclear factor kappa-light-chain-enhancer of activated B cells, cleaved-cysteinyl aspartate-specific proteinase-3 (caspase-3) and tumour necrosis factor-α levels were determined by western blot. (nih.gov)
• However, the expression levels of AKT and glycogen synthase kinase-3 beta were not significantly different in three groups, but the expression levels of phosphorylated Ser/Thr protein kinase and phosphorylated glycogen synthase kinase-3 beta were significantly decreased in the control diabetes mellitus and fluctuated blood glucose groups compared to control group, and levels in the fluctuated blood glucose group were significantly less than in the control diabetes mellitus group. (nih.gov)
• The levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), glutathione disulfide (GSSG), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed by ELISA. (ac.ir)

PI3K1

• Several AGC kinases are involved in mediating signaling downstream of phosphatidyl-inositol-4,5-bisphosphate 3-kinase (PI3K) in response to a wide range of stimuli such as growth factors and hormones. (eu.org)

Enzyme4

• Aspartate β-hydroxylase (ASPH) is an enzyme overexpressed in human hepatocellular carcinoma (HCC) tumors that participates in the malignant transformation process. (elsevier.com)
• Aspartate aminotransferase (ast or sgot) - an enzyme helpful in evaluating liver function. (studiocraft.com)
• Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase. (umbc.edu)
• Cardiac enzyme tests showed a highly elevated level of troponin Ic at 3.51 μg/L. Alanine aminotransferase (ALT) was at 50 U/L, aspartate aminotransferase (AST) at 202 U/L and creatine kinase (CK) at 2,275 U/L. The electrocardiogram showed a 12-lead diffuse, concave ST segment elevation without low-voltage QRS complexes. (biomedcentral.com)

Superfamily3

• The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. (embl-heidelberg.de)
• There are two main subdivisions within the superfamily: the protein-serine/threonine kinases and the protein-tyrosine kinases. (embl-heidelberg.de)
• Bacterial histidine kinases (HK) are associates from the GHKL superfamily, which share a distinctive adenosine triphosphate (ATP)-binding Bergerat fold. (welbourneprimary.com)

Checkpoint kinase2

• Characterization of the activation domain of the Rad53 checkpoint kinase / S. Fiorani, G. Mimun, L. Caleca, D. Piccini, A. Pellicioli. (unimi.it)
• We show that the integrity of CDK consensus sites and the activity of Cdc28 are required for both the activation of the Chk1 checkpoint kinase and its interaction with Rad9. (ul.ie)

Calcium2

• Connections to Calcium-Calmodulin-Dependent Protein Kinase Type 2 are shown below. (vanderbilt.edu)
• Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II. (vanderbilt.edu)

Regulation5

• n mammals, cell cycle progression is controlled by cyclin-dependent kinases, among which CDK1 plays important roles in the regulation of the G2/M transition, G1 progression and G1/S transition. (us.es)
• Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII). (semanticscholar.org)
• Regulation of aspartate-derived amino acid homeostasis in potato plants (Solanum tuberosum L.) by expression of E-coli homoserine kinase. (mpg.de)
• The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina. (cocites.com)
• The mediators of the DNA damage response (DDR) are highly phosphorylated by kinases that control cell proliferation, but little is known about the role of this regulation. (ul.ie)

Homology1

• Taxonomy and function of C1 protein kinase C homology domains. (embl.de)

Metabolism1

• The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. (cocites.com)

Upstream3

• The mechanisms involved demonstrate that ASPH binds to glycogen synthase kinase 3β and inhibits its subsequent interactions with protein kinase B and p38 upstream kinases as shown by coimmunoprecipitation. (elsevier.com)
• Several variants of the motif exist, and for many kinases, the motif has been shown to operate in trans to bind and activate the upstream activating kinase PDK1. (eu.org)
• PDK1 functions as a common upstream activator by phosphorylating the other AGC kinases at their activation loop. (eu.org)

Isoform1

• Interestingly, we found that the rad53-T358D mutation severely affects the kinase activity and causes accumulation of the S129-phosphorylated isoform of histone H2A, even during an unperturbed cell cycle, thus indicating the accumulation of spontaneous DNA breaks. (unimi.it)

Pyruvate1

• Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina. (cocites.com)

Leucine zipper1

• Derek S. Welsbie, MD, PhD: Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. (glaucoma.org)

Concentrations2

• 0.05) between control group and experimental group for alanine aminotransferase, aspartate aminotransferase, urine red blood cell and creatine kinase concentrations at immediately after the boxing match and 8 hours after the boxing match. (tci-thaijo.org)
• In aspartate-perfused kidneys, the current presence TZFP of 3-MPA, at concentrations that totally blocked glucose build up within the perfusate, didn't affect the price of NH3 creation and had just a minor influence on the pace of aspartate uptake. (osi-930.com)

Phosphate2

• We demonstrate that acetyl phosphate phosphorylates OmpR at aspartate 55, the same residue phosphorylated by the kinase EnvZ. (utmb.edu)
• The alpha-C helix is part of a hydrophobic pocket and an adjacent phosphate-binding site in the N-lobe, called the PIF pocket, which interacts with the AGCK docking motif (PDK1 Interacting Fragment (PIF) / hydrophobic motif (HM)) that is present in the C-tail of AGC kinases. (eu.org)

Serine2

• The AGC kinases constitute a large family of serine/threonine protein kinases consisting of 60 members, including the cAMP- and cGMP-dependent protein kinases (PKA and PKG), the protein kinase C family (PKC), PKB/Akt, ribosomal protein S6 kinases, and the 3-phosphoinositide-dependent protein kinase (PDK1). (eu.org)
• The AGCK docking motif of some AGC kinases, including PKA, does not contain a phosphorylatable serine/threonine residue or an acidic aspartate/glutamate residue present in the DOC_AGCK_PIF_1 and DOC_AGCK_PIF_2 motif variants, respectively. (eu.org)

Cytoplasmic1

• The cytoplasmic area includes two distinctive domains: a four-helical pack dimerization domains, which homes the conserved His residue, and an 1536200-31-3 IC50 ATP-binding catalytic domains.6,7 The ATP-binding theme of bacterial HKs dramatically differs from the normal eukaryotic ATP-binding domains of Ser, Thr, and Tyr kinases. (welbourneprimary.com)

Mutations1

• The mutations most commonly seen in PDAC substitution of either valine or aspartate in place of glycine at codon 12 mimic the GTP-bound form or active conformation of (13 14 15 A transgenic mouse model directing oncogenic KRAS activity to the pancreas promoter sequence directs expression of human specifically to the acinar cells of the exocrine pancreas. (lifescienceexec.com)

Eukaryotic3

• We herein describe the characterization of EmPlk1, encoded by the gene emplk1 , which displays significant homologies to members of the Plk1 sub-family of Polo-like kinases that regulate mitosis in eukaryotic cells. (plos.org)
• Both these regions are conserved in Eukaryotic AGC kinases, except for PDK1, which lacks the C-tail. (eu.org)
• Both the PIF pocket and the C-terminal region are conserved in Eukaryotic AGC kinases, except for PDK1, which lacks the C-terminal part. (eu.org)